Gamete intrafallopian transfer vs superovulation with intrauterine insemination for the treatment of infertility.
Superovulation with intrauterine insemination (SO-IUI) has been suggested as an alternative to gamete intrafallopian transfer (GIFT), despite the absence of controlled or comparative trials. We retrospectively analyzed all GIFT and SO-IUI cycles performed concurrently from January 1985 to August of 1987 at a single university center. Pregnancy rates were significantly better for GIFT than SO-IUI (P less than 0.001), with an odds ratio of 3.25 (P = 0.001). Stepwise multiple logistic regression identified factors that correlate with pregnancy: absence of endometriosis (P = 0.05), infertility less than 3 years' duration (P = 0.002), TMS greater than or equal to 30 X 10(6) (P = 0.005), and treatment with GIFT rather than SO-IUI (P = 0.001). These data give a first approximation of the increased efficacy of GIFT versus SO-IUI and provide valuable insight into significant confounding variables to be considered when planning a randomized, prospective trial to evaluate these techniques.
Kaplan
C R
CR
Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio 78284.
Olive
D L
DL
Sabella
V
V
Asch
R H
RH
Balmaceda
J P
JP
Riehl
R M
RM
Groff
T R
TR
Burns
W N
WN
Schenken
R S
RS
D000328:Adult; D005260:Female; D015181:Gamete Intrafallopian Transfer / Q000706:statistics & numerical data; D006801:Humans; D007246:Infertility / Q000628:therapy*; D007315:Insemination, Artificial / Q000706:statistics & numerical data; D010060:Ovulation; D011247:Pregnancy; D012044:Regression Analysis; D012189:Retrospective Studies; D013480:Superovulation