title: [The main pathogenetic mechanisms of disorders of the detoxication function of the liver in endogenous toxemia of various etiologies].
abstract: The mechanisms of cell proliferative activity regulation under the effect of growth factors, mitogens, virus transformation, etc. were analyzed. Changes in the location of cAMP-dependent protein kinase caused by these factors, the effect of the nerve growth factor on the activities of protein kinase and high-affinity ATPase, and the mechanism of antiproliferative action of staphylococcal enterotoxin A were specified. Data on receptor-independent intracellular penetration of protein factors hydrophobized by fatty acid residues are overviewed.
authors.forename: M E
authors.initials: ME
authors.lastname: Krakovskiĭ
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Ashirmetov
mesh_terms: D000818:Animals; D001711:Biotransformation / Q000502:physiology*; D002056:Burns / Q000150:complications / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000172:deficiency*; D004731:Endotoxins / Q000378:metabolism*; D007415:Intestinal Obstruction / Q000150:complications / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D010019:Osteomyelitis / Q000150:complications / Q000378:metabolism; D051381:Rats; D013203:Staphylococcal Infections / Q000150:complications / Q000378:metabolism; D014115:Toxemia / Q000209:etiology*
chemical_list: D004731:Endotoxins; D003577:Cytochrome P-450 Enzyme System
vernacular_title: Osnovnye patogeneticheskie mekhanizmy narusheniia detoksikatsionnoĭ funktsii pecheni pri éndogennykh intoksikatsiiakh razlichnogo geneza.