[The hypothalamo-hypophyseal neurosecretory system of rats with altitude hypoxia].
Neurosecretory components of the hypothalamic-pituitary neurosecretory system of white rats react to high mountain hypoxia by a phase-by-phase mobilization of neurosecretory compounds (NSC). Their peak quantities in the sphere equal to their total content in the supraoptic nucleus occur on adaptation day 20. Assuming that on day 20 neurosecretory cells of type Ia amount to 14%, we obtain 64.3 X X 10(-4) quanta of NSC. This value is in agreement with the data on a lower increase of NSC in the pituitary during 14 days of adaptation to high mountain hypoxia. The level of migration of Homori-positive granules measured functionally was greater than the quantum content of NSC in the supraoptic nucleus. This points to axoplasm stagnation in the course of NSC transport induced by aggregation of neurosecretory granules at the phase of active adaptation. An important factor here seems to be the structural state of the presynaptic membrane itself which determines the quantum transport of NSC. On adaptation days 3 and 10 spontaneous discharge of NSC increases drastically (large percentage of NSC of type Ia); on adaptation days 20 and 40 synthesis of NSC in hypoxic terminals also grows. It is probable that high mountain hypoxia affects metabolism of the terminal--NSC discharge and vesicular apparatus--on adaptation day 60.
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D000222:Adaptation, Physiological / Q000502:physiology; D000532:Altitude Sickness / Q000473:pathology* / Q000503:physiopathology; D000818:Animals; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology / Q000648:ultrastructure*; D000860:Hypoxia / Q000473:pathology*; D051381:Rats; D013495:Supraoptic Nucleus / Q000503:physiopathology / Q000648:ultrastructure*; D013997:Time Factors
Gipotalamo-gipofizarnaia neĭrosekretornaia sistema krys v usloviiakh vysokogornoĭ gipoksii.