[Effectiveness of cytochrome P-450 inducer Benzonal in the treatment of acute hepatitis].
Forty-six patients with acute viral hepatitis (AVH) varying in severity received standard therapy. Twenty of them were given an adjuvant 6-day course of benzonal. The activity of liver monooxygenase was evaluated before, after treatment (for 6-8 days) and at the height of the disease using antipyrine++ test. AVH was found to inhibit liver monooxygenase activity, this inhibition being on the increase with growing severity of the disease. Standard therapy failed to manage this condition, whereas the addition of benzonal lead to recovery of normal values of the antipyrine++ test. Benzonal-treated patients showed more rapid discontinuation of clinical and biochemical symptoms, their hospital stay was shorter. It is concluded that antipyrine++ test is an adequate criterion in the assessment of AVH gravity and in the prognosis of its course. An adjuvant treatment of AVH with benzonal promotes the recovery of monooxygenase system of hepatocytes resulting in disappearance of the clinical symptoms of the disease.
Makhmudov
O S
OS
Khakimov
Z Z
ZZ
Tsipkina
S V
SV
Pashutina
I V
IV
D000208:Acute Disease; D000328:Adult; D001463:Barbiturates / Q000627:therapeutic use*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis* / Q000172:deficiency; D004790:Enzyme Induction / Q000187:drug effects / Q000502:physiology; D005260:Female; D006506:Hepatitis A / Q000188:drug therapy* / Q000201:enzymology; D006509:Hepatitis B / Q000188:drug therapy* / Q000201:enzymology; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008875:Middle Aged
D001463:Barbiturates; D003577:Cytochrome P-450 Enzyme System; C002915:benzobarbital
Effektivnos't induktora tsitokhroma P-450-benzonala v terapii ostrogo gepatita.