[Metabolism of an antiepileptic drug halonal in experimental studies].
A study was made of metabolism of the new antiepileptic drug halonal in guinea-pigs. It was established that on oral administration halonal was not absorbed from the intestinal tract and only its metabolite, phenobarbital, was detectable in blood serum. It is assumed that halonal produces a therapeutic action only thanks to phenobarbital, its pharmacologically active metabolite.
Okudzhava
V M
VM
Chankvetadze
B G
BG
Rogava
M M
MM
Rukhadze
M D
MD
D000818:Animals; D000927:Anticonvulsants / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001463:Barbiturates / Q000494:pharmacology* / Q000627:therapeutic use; D001682:Biological Availability; D055598:Chemical Phenomena; D002621:Chemistry; D004353:Drug Evaluation, Preclinical; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D006168:Guinea Pigs; D007408:Intestinal Absorption / Q000502:physiology; D010634:Phenobarbital / Q000493:pharmacokinetics* / Q000627:therapeutic use
D000927:Anticonvulsants; D001463:Barbiturates; C062695:halonal; D010634:Phenobarbital
Metabolizm protivoépilepticheskogo preparata galonala v éksperimente.