title: Evolution of experimental mild and severe chronic renal failure in the rat. Mathematical models.
abstract: Two degrees of renal insufficiency were obtained in female Wistar rats, one mild (M) and the other severe (S) by surgical resection of 2/3 or 3/4 of one kidney, followed by contralateral nephrectomy. The serum creatinine concentration (Cr) s was evaluated as an index of renal function and followed in the two mentioned groups under a normal protein diet and in "S" also under a low protein diet. The evolution was assessed by two functions of time: 1/(Cr) s and log e (Cr) s. Several differences between M and S were detected. In M a smaller initial and maximal increase in (Cr) s than in S followed by a plateau was observed; in S a decrease in (Cr) s posterior to the initial increase was detected attributed to hyperfiltration followed by a sustained increment. The lowering of protein content in the diet caused a decrement in (Cr) s. In both groups a better adjustment with the logarithmic than with the inverse function was obtained, although poorer in S rats owing to a larger variability. In order to look for a mathematical link between inulin clearance (Cl In) and (Cr) s, the relationship between Cl In vs. 1/(Cr) s, and log e Cl In vs. log e (Cr) s was studied in normal and in rats in renal insufficiency. By regression analysis we found a good adjustment with both functions from 0.58 to 1.60 mg % (Cr) s.
authors.affiliation: Instituto de Fisiología Experimental, CONICET. y Cátedra de Biofísica, Universidad Nacional de Rosario, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: MacLaughlin
authors.forename: S
authors.initials: S
authors.lastname: Galeazzi
authors.forename: S
authors.initials: S
authors.lastname: Weinschelbaum-Jairala
mesh_terms: D000818:Animals; D001835:Body Weight; D003404:Creatinine / Q000097:blood*; D004032:Diet; D005260:Female; D005919:Glomerular Filtration Rate; D007444:Inulin; D007668:Kidney / Q000503:physiopathology / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000503:physiopathology*; D009392:Nephrectomy; D009399:Nephrons / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012044:Regression Analysis
chemical_list: D007444:Inulin; D003404:Creatinine