title: Intrathecal porcine calcitonin enhances the release of [Met5]enkephalin-like material from the rat spinal cord.
abstract: Perfusion of the intrathecal space of halothane-anaesthetized rats with artificial cerebro-spinal fluid supplemented with porcine calcitonin (1-10 microM) produced a significant increase (+67-110%) in the spinal release of [Met5]enkephalin-like material. The effect of porcine calcitonin was markedly enhanced (+100%) in animals receiving a continuous i.v. infusion of the opioid antagonist naloxone (65 micrograms/kg per min). These data strongly suggest that the antinociceptive effect of intrathecal porcine calcitonin might involve a stimulatory action of the hormone on spinal enkephalinergic interneurones. In addition, presynaptic opioid autoreceptors probably control the activity of these neurones in the rat.
authors.affiliation: INSERM U288, Neurobiologie Cellulaire et Fonctionnelle, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Collin
authors.forename: S
authors.initials: S
authors.lastname: Bourgoin
authors.forename: P
authors.initials: P
authors.lastname: Gorce
authors.forename: M
authors.initials: M
authors.lastname: Hamon
authors.forename: F
authors.initials: F
authors.lastname: Cesselin
mesh_terms: D000818:Animals; D002116:Calcitonin / Q000008:administration & dosage / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000378:metabolism*; D007278:Injections, Spinal; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000378:metabolism*; D013552:Swine
chemical_list: D009270:Naloxone; D004744:Enkephalin, Methionine; D002116:Calcitonin