Flavovirin--a new antifungal antibiotic produced by the pyrenomycete Melanconis flavovirens.
The pyrenomycete Melanconis flavovirens was found to produce a mixture of two antifungal antibiotics. The first has been already described; the antibiotic is identical with thermozymocidin (myriocin). The second antibiotic is a new compound, whose isolation and identification is presented in this paper. The chemical structure of this substance (C21H37NO5) was determined to be 2-amino-2-hydroxymethyl-3,4-trans-epoxy-14-oxo-eicos-trans-6-enoic acid. After the producer it was named flavovirin and it possesses strong activity against yeasts and a moderate effectivity against filamentous fungi.
Sailer
M
M
Institute of Microbiology, Czechoslovak Academy of Sciences, Prague.
Sasek
V
V
Sejbal
J
J
Budĕsínký
M
M
Musílek
V
V
D000596:Amino Acids / Q000032:analysis; D000605:Amino Alcohols / Q000032:analysis; D000935:Antifungal Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D005229:Fatty Acids, Monounsaturated / Q000302:isolation & purification; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D015003:Yeasts / Q000187:drug effects
D000596:Amino Acids; D000605:Amino Alcohols; D000935:Antifungal Agents; D005229:Fatty Acids, Monounsaturated; C062366:flavovirin; C001996:thermozymocidin