title: [The antifibrinolytic action of the D-dimer fragment].
abstract: The effect of D-dimer on the process of plasmin hydrolysis of unstabilized and crosslinked fibrin has been studied. Less degraded early, intermediate, and late products of fibrin cleavage have been revealed by electrophoresis of reduced and nonreduced samples. The molecular mechanism of antifibrinolytic effect of the D-dimer is supposed to be determined by shielding of peptide regions of monomer fibrin, localized both in N-terminal area of beta chain and in alpha, beta, and gamma chains between D and E domains. A notion has been proposed of autoinhibition of fibrinolytic reaction as a phenomenon related to the physical-chemical regulation of fibrinogen transformation into fibrin.
authors.forename: M A
authors.initials: MA
authors.lastname: Rozenfel'd
authors.forename: L S
authors.initials: LS
authors.lastname: Khavkina
authors.forename: V B
authors.initials: VB
authors.lastname: Leonova
authors.forename: K B
authors.initials: KB
authors.lastname: Gershkovich
authors.forename: M V
authors.initials: MV
authors.lastname: Vasil'eva
mesh_terms: D000933:Antifibrinolytic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001797:Blood Protein Electrophoresis; D005337:Fibrin / Q000187:drug effects / Q000378:metabolism; D005338:Fibrin Fibrinogen Degradation Products / Q000302:isolation & purification / Q000494:pharmacology*; D005340:Fibrinogen / Q000187:drug effects / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D000933:Antifibrinolytic Agents; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005337:Fibrin; D005340:Fibrinogen
vernacular_title: Antifibrinoliticheskoe deĭstvie fragmenta D-dimera.