Fasciculic acids A, B and C as calmodulin antagonists from the mushroom Naematoloma fasciculare.
Three new fasciculol esters, fasciculic acids A (1), B (2) and C (3), having potent calmodulin antagonistic activity were isolated from the toxic mushroom Naematoloma fasciculare (Fr.) Karst. Their structures were elucidated on the basis of spectral and chemical evidence.
Takahashi
A
A
Kusano
G
G
Ohta
T
T
Ohizumi
Y
Y
Nozoe
S
S
D000363:Agaricales / Q000032:analysis*; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D055598:Chemical Phenomena; D002621:Chemistry; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
D002147:Calmodulin; D014315:Triterpenes; C063645:fasciculic acid B; C063646:fasciculic acid C; C063644:fasciculic acid A