Central lesion abolishes the beneficial effect of hypertonic saline on circulatory shock produced by compound 48/80 in rats.
The purpose of the present study was to examine the protective action of a 7.5% hypertonic NaCl solution (HS) on the circulatory shock produced by compound 48/80 (48/80) in rats and to determine the effect of the AV3V lesion on the protective action of HS. Intravenous injection of 48/80 into sham-operated rats resulted in an immediate drop of mean arterial pressure (MAP). In sham-operated rats, intravenous injection of HS prevented the drop of MAP produced by 48/80, but HS was ineffective in AV3V-lesioned rats. These results show that HS had a protective action on the circulatory shock produced by 48/80 and that the AV3V region plays an important role in this protective action.
Giraldelo
C M
CM
Laboratório de Farmacologia, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Araraquara, Brasil.
Colombari
E
E
Menani
J V
JV
Fracasso
J F
JF
D000818:Animals; D002552:Cerebral Ventricles / Q000601:surgery; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012769:Shock / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D012462:Saline Solution, Hypertonic; D003189:p-Methoxy-N-methylphenethylamine