Peripherally administered serotonin 5-HT3 receptor antagonists reduce inflammatory pain in rats.
Intraplantar administration of serotonin 5-HT3 receptor antagonists ICS 205-930 and MDL 72222 (1-100 micrograms; 50 microliters) produced dose-related analgesia against formalin-induced acute- and Freunds adjuvant-induced chronic-inflammatory pain in rats. 5-HT3 receptor antagonists had greater effect in the chronic pain test than in the acute paradigm. In both tests, ICS 205-930 was more potent than MDL 72222. These data further support the involvement of peripheral 5-HT3 sites in inflammatory pain, and suggest the utility of selective 5-HT3 receptor antagonists as peripheral analgesics.
Giordano
J
J
Neuropharmacology Laboratory, College of Pharmacy and Health Sciences, Drake University, Des Moines, IA 50311.
Rogers
L V
LV
D000208:Acute Disease; D000700:Analgesics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002908:Chronic Disease; D007211:Indoles / Q000494:pharmacology; D008297:Male; D009619:Nociceptors / Q000187:drug effects; D010147:Pain Measurement; D051381:Rats; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D014326:Tropanes / Q000494:pharmacology; D000077526:Tropisetron
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007211:Indoles; D012702:Serotonin Antagonists; D014326:Tropanes; D000077526:Tropisetron; C042253:bemesetron