Nitrogranulogen: a strong inhibitor of human lymphocyte proliferation.
The immunosuppressive activity of an alkylating agent Nitrogranulogen (NTG) was studied and compared with a major active metabolite of cyclophosphamide (4HCy). Both agents inhibit the human T and B cell proliferation in vitro induced by pure T cell (PHA) and B cell (SAC) mitogens. NTG is slightly less active than 4HCy and it is much less toxic to human lymphocytes. Furthermore, NTG appears to have a more selective inhibitory action against B cells.
Wasik
M
M
Department of Experimental Immunosuppression, Medical School, Warsaw.
Górski
A
A
D002478:Cells, Cultured; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects; D008466:Mechlorethamine / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D008466:Mechlorethamine