Cross-neutralization of thrombin-like enzymes in snake venoms by polyvalent antivenoms.
Five polyvalent antivenoms (Crotalidae; Orient, North, Central and South Africa) were tested for their ability to neutralize the thrombin-like activity of snake venoms (Bitis gabonica, Agkistrodon acutus, Bothrops asper, B. atrox, Crotalus adamanteus). Considerable cross-neutralization was observed. Anti-coagulase antibodies were isolated from an antivenom by affinity chromatography using a purified enzyme from Bitis gabonica venom. These antibodies neutralized the activity of most snake venom coagulant enzymes.
Claus
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Zentrum der Rechtsmedizin, University of Frankfurt, F.R.G.
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D000997:Antivenins / Q000276:immunology*; D003435:Crotalid Venoms / Q000276:immunology*; D009500:Neutralization Tests; D013917:Thrombin / Q000037:antagonists & inhibitors*; D014757:Viper Venoms / Q000276:immunology*
D000997:Antivenins; D003435:Crotalid Venoms; D014757:Viper Venoms; D013917:Thrombin