The enhancement of lymphocyte localization in skin sites of sheep by tumor necrosis factor alpha.
Using radiolabelled lymphocytes, we have demonstrated that recombinant bovine TNF alpha is potent in its ability to recruit lymphocytes from the blood into TNF alpha injected skin sites. Furthermore, TNF alpha mediates this observed increase in lymphocyte accumulation in a clear dose-response manner, and may play an important role in the mediation of DTH reactions in the skin.
Kalaaji
A N
AN
Department of Pathology, Faculty of Medicine, University of Toronto, Ontario, Canada.
McCullough
K
K
Hay
J B
JB
D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D005260:Female; D006968:Hypersensitivity, Delayed; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D012756:Sheep; D012867:Skin / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D014409:Tumor Necrosis Factor-alpha