title: Effect of ofurace, oxadixyl, and alachlor on xenobiotic biotransformation in the rat liver.
abstract: Ofurace, oxadixyl, and alachlor were studied for their effect on hepatic xenobiotic biotransformation in male rats by dosing i.p. with 1 or 100 mg/kg of chemical for 7 days. Ofurace decreased ethoxyresorufin-O-deethylase and aniline p-hydroxylase activities but induced ethoxycoumarin-O-deethylase activity. Glutathione S-transferase and aminopyrine N-demethylase activities responded in a non dose-dependent manner, while cytochrome P-450 content and aldrin epoxidase activities were unchanged. Oxadixyl induced P-450 content, and ethoxycoumarin-O-deethylase and aminopyrine N-demethylase activities. It left ethoxyresorufin-O-deethylase, aldrin epoxidase and epoxide hydrolase activities unchanged and decreased aniline p-hydroxylase activities. Alachlor induced all activities excepting aldrin epoxidase (no change) and aniline p-hydroxylase (decreased). The data indicate that each of these acylanilide pesticides interacts with the monooxygenase system but with differing patterns.
authors.forename: C
authors.initials: C
authors.lastname: Leslie
authors.forename: G F
authors.initials: GF
authors.lastname: Reidy
authors.forename: N H
authors.initials: NH
authors.lastname: Stacey
mesh_terms: D000081:Acetamides / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005663:Furans / Q000633:toxicity*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010080:Oxazoles; D051381:Rats; D011919:Rats, Inbred Strains; D015262:Xenobiotics / Q000493:pharmacokinetics*
chemical_list: D000081:Acetamides; D005663:Furans; D010080:Oxazoles; D015262:Xenobiotics; C000188:alachlor; C062369:ofurace; C062370:oxadixyl; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases