The evidence for the involvement of the 5-HT1A receptor in 5-HT syndrome induced in mice by tryptamine.
The involvement of the 5-HT1A receptor in the 5-HT syndrome (head weaving and hindlimb abduction) induced in DBA mice by tryptamine was investigated. Methysergide, (-)propranolol and spiperone suppressed both the head weaving and hindlimb abduction induced by tryptamine. However, ketanserin and ICS 205-930 did not affect them. Haloperidol induced small decreases in the head weaving, but had no effect on the hindlimb abduction. These results indicate that the 5-HT syndrome induced by tryptamine in mice is mediated by the 5-HT1A receptor. Therefore, 5-HT syndrome may also be associated with the 5-HT1A receptor in mice, as it is in rats.
Yamada
J
J
Department of Pharmacology, Kobe Women's College of Pharmacy, Japan.
Sugimoto
Y
Y
Horisaka
K
K
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D051379:Mice; D008811:Mice, Inbred DBA; D011433:Propranolol / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000145:classification / Q000502:physiology*; D012701:Serotonin / Q000502:physiology; D013134:Spiperone / Q000494:pharmacology; D014363:Tryptamines / Q000494:pharmacology*
D011985:Receptors, Serotonin; D014363:Tryptamines; D012701:Serotonin; C030820:tryptamine; D013134:Spiperone; D007650:Ketanserin; D011433:Propranolol; D006220:Haloperidol; D008784:Methysergide