[Mechanism of the effect of dibasol on the contractile and electric activities of the smooth muscle of the portal vein].
The effects of dibasol on spontaneous electrical and contractile activities as well as on the reactions evoked by hyperkalemic solution and noradrenaline were studied in smooth muscle of rabbit portal vein. It was shown that dibasol blocked the potential-operated influx Ca2+ into smooth muscle cells. The noninactivating calcium channels were found to be more sensitive to dibasol than inactivating ones. Significant part of the tonic contraction induced by noradrenaline was resistant to dibasol suggesting its weak effect on Ca2+ influx through calcium channels operated by alpha 1-adrenoceptors. It is supposed that vasodilative effect of dibasol is associated with blocking the influx Ca2+ through potential-operated noninactivating calcium channels into smooth muscle cells.
Gurkovskaia
A N
AN
Gokina
N I
NI
Shuba
M F
MF
Kazak
L I
LI
Chekman
I S
IS
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D003470:Culture Media; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D009125:Muscle Relaxants, Central; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D011169:Portal Vein / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits
D001562:Benzimidazoles; D003470:Culture Media; D009125:Muscle Relaxants, Central; C004453:bendazole
Issledovanie mekhanizma deĭstviia dibazola na sokratite'lnuiu i élektricheskuiu aktivnos't gladkoĭ myshtsy vorotnoĭ veny.