[Growth and proliferation stimulating effect of extremely small doses of nitrosomethylurea].
The increase to 30-50% of spleen weight of intact and with La leukemia C57Bl/6 mice after 5 days i.p. anticancer drug nitrosomethylurea (10(-3)-10(-8) g/kg) injection was observed. The reaction of intact spleen was more expressed than that of leukemic spleen. The growth-stimulating effect of nitrosomethylurea supersmall doses was accompanied with perturbation in 3H-thymidine cell incorporation, that assume a certain change in cell proliferation.
Krutova
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D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000473:pathology*; D008770:Methylnitrosourea / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects / Q000473:pathology
D008770:Methylnitrosourea
Stimuliruiushchee rost i proliferatsiiu deĭstvie sverkhmalykh doz nitrozometilmocheviny.