title: Clinical and experimental studies of coronary heart disease treated with yi-qi huo-xue injection.
abstract: The purpose of the present work was to evaluate the clinical efficacy and the mechanism of Yi-qi Huo-xue Injection (YHI) in treatment of coronary heart disease. YHI consists of Ginseng, Astragalus and Angelicae Sinensis. The 10% dextrose serves as a placebo. The results were as follows: 1. the frequency and severity of angina episodes were reduced by 90.63%; 2. the ischemic ST-T in ECG was improved in 56.25% of cases; 3. the tolerance to treadmill exercise was increased from 348.50 to 503.50 M.; 4. the left ventricular function was strengthened, PEP/LVET ratio reduced from 0.45 to 0.36, the activity of (Na(+)-K+) ATPase in myocardial cell membrane of rats inhibited by 19.2%; 5. the blood viscosity and erythrocyte electrophoretic time lowered; 6. the adhesion and aggregation of platelet in patients with CHD were inhibited by 27% and 59.4% respectively; 7. the plasma TXB2 level in CHD was reduced from 260.28 +/- 164.4 to 139.29 +/- 57.01 pg/ml; 8. the plasma 6-keto-PGF1 alpha level in CHD was increased from 33.45 +/- 22.5 to 57.48 +/- 13.1 pg/ml, and in rats from 185.77 to 366.33 pg/ml. The differences were all statistically significant (P less than 0.05-0.01) in comparison with the placebo group.
authors.forename: J Z
authors.initials: JZ
authors.lastname: Liao
authors.forename: J J
authors.initials: JJ
authors.lastname: Chen
authors.forename: Z M
authors.initials: ZM
authors.lastname: Wu
authors.forename: W Q
authors.initials: WQ
authors.lastname: Guo
authors.forename: L Y
authors.initials: LY
authors.lastname: Zhao
authors.forename: L M
authors.initials: LM
authors.lastname: Qin
authors.forename: S R
authors.initials: SR
authors.lastname: Wang
authors.forename: Y R
authors.initials: YR
authors.lastname: Zhao
mesh_terms: D001809:Blood Viscosity / Q000187:drug effects; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006321:Heart / Q000503:physiopathology; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors
chemical_list: D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors