[The hypolipidemic and antiatherosclerotic action of absorbable and nonabsorbable substances in the intestines].
Hypolipidemic effect of the polyphenol compound triophen possessing antihypoxic activity was demonstrated in chronic experiments on rabbits. It was also shown that a new derivative of methylxanthine, which does not penetrate the blood--brain barrier, produces a hypolipidemic and antiatherosclerotic effect. Experiments on rats, guinea pigs, and rabbits with induced hyperlipidemia revealed a hypolipidemic effect of new complex compounds which are not absorbed in the intestine--steroid glycosides digitonin and tomatonin immobilized on a polymer. These substances resemble cholesteramine in activity but are distinguished by solubility, low toxicity, and a mechanism of action which is more physiological.
Ryzhenkov
V E
VE
Chistiakova
A M
AM
Okunevich
I V
IV
D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000378:metabolism; D002784:Cholesterol / Q000032:analysis; D004036:Diet, Atherogenic; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007408:Intestinal Absorption / Q000187:drug effects*; D008099:Liver / Q000032:analysis; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats
D000960:Hypolipidemic Agents; D002784:Cholesterol
Gipolipidemicheskoe i antiateroskleroticheskoe deĭstvie veshchestv, vsasyvaiushchikhsia i ne vsasyvaiushchikhsia v kishechnike.