[Lepromatous leprosy: clinical and electrophysiological arguments in favor of axonal multi-neuritis].
This work was undertaken because there were only few reports on neurological aspects on lepromatous leprosy. We studied 30 patients suffering from lepromatous leprosy who, at their first visit to the Institute had never been treated. The clinical examination included a quantitative evaluation of the neurological status following the method developed by Pearson. Motor and sensory nerve conduction velocities were measured: values of conduction velocity and distal amplitude were analysed and compared to those of a group of 22 healthy subjects.


CONCLUSIONS
(a) There is a high frequency of clinical and especially electrophysiological neurological impairment. This impairment can be extremely precocious and may happen shortly after the first cutaneous signs. (b) Nervous impairment is diffuse, bilateral but not homogeneous. These are characteristics of mononeuritis multiplex. Impairement is predominantly sensitive and tactile sensibility is more involved than thermo-algic sensation. (c) The radial superficial nerve is the most frequently involved clinically and electrophysiologically. (d) The electrophysiological results, showing a normal or slightly reduced conduction velocity and a low amplitude of evoked potentiel are in favour of a predominantly axonal damage.
Tzourio
C
C
Institut de Léprologie Appliquée de Dakar (ILAD) Fondation de l'Ordre de Malta, Annexe Dakar, Sénégal.
Henry
P
P
Boucher
P
P
Parent
M
M
Millan
J
J
Métral
S
S
D001369:Axons / Q000502:physiology*; D006801:Humans; D015440:Leprosy, Lepromatous / Q000473:pathology / Q000503:physiopathology*; D008475:Median Nerve / Q000503:physiopathology; D009046:Motor Neurons / Q000502:physiology; D009132:Muscles / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology; D009443:Neuritis / Q000473:pathology / Q000503:physiopathology*; D009475:Neurons, Afferent / Q000502:physiology; D011826:Radial Nerve / Q000503:physiopathology; D012677:Sensation / Q000502:physiology; D014459:Ulnar Nerve / Q000503:physiopathology
Lèpre lépromateuse: arguments cliniques et électrophysiologiques en faveur d'une multinévrite axonale.