[The rabbit ear model as an acnegenicity test. 2. Effect of coal tar on follicle and sebaceous gland epithelium tumor induction].
Tar produced from hard coal was found to be acanthogenic to the interfollicular epiderm of rabbit ear skin and comedogenic to follicular epithelium in short-term (two weeks) and long-term (12 weeks) tests. Histological and autoradiographic experiments revealed a hyperproliferative effect in all cases in long-term tests. This contrasts with the atrophying effects reported by other authors. Tar application reduced the sebaceous gland area per follicle. Benignant epidermal tumours consisting of papillomas with a striking degree of sebaceous gland proliferation appeared on the rabbit ear skin after 8 weeks at the earliest.
Zimmermann
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R
D000818:Animals; D003033:Coal Tar / Q000633:toxicity*; D004431:Ear, External; D004848:Epithelium / Q000187:drug effects; D010212:Papilloma / Q000139:chemically induced*; D011817:Rabbits; D012626:Sebaceous Gland Neoplasms / Q000139:chemically induced*; D012627:Sebaceous Glands / Q000187:drug effects*; D012878:Skin Neoplasms / Q000139:chemically induced*
D003033:Coal Tar
Kaninchenohrmodell als Akneigenitätstest. 2. Mitteilung: Wirkung von Steinkohlenteer auf Follikel- und Talgdrüsenepithel--Tumorinduktion.