title: Effectiveness of WR 163577 against animal trypanosomes in goats and mice.
abstract: A bisquinaldine, 1,6-bis-(6-amino-2-methyl-4-quinolylamino) hexane, was tested against Trypanosoma brucei ssp. in goats and against T. brucei, T. congolense and T. vivax in mice. At doses of 25 and 100 mg kg-1, the drug protected goats for at least 90 days against blood challenge with T. brucei ssp. Fifty to sixty per cent of goats challenged 180 days after treatment were protected, but all goats challenged 270 days after treatment became infected. In mice, bisquinaldine also had a marked effect on T. brucei, but only a minimal effect on T. vivax and no apparent effect on T. congolense. No drug toxicity was noted in mice even at doses of 2000 mg kg-1. Both a short-term (25 and 100 mg kg-1) and long term (100 mg kg-1) toxicity was apparent in goats treated with bisquinaldine.
authors.affiliation: Walter Reed Project, Veterinary Research Laboratory, Ministry of Agriculture and Livestock Production, Kabete, Kenya.
authors.forename: M J
authors.initials: MJ
authors.lastname: Reardon
authors.forename: B T
authors.initials: BT
authors.lastname: Wellde
authors.forename: R M
authors.initials: RM
authors.lastname: Muriithi
authors.forename: D A
authors.initials: DA
authors.lastname: Chumo
authors.forename: S
authors.initials: S
authors.lastname: Towett
authors.forename: J
authors.initials: J
authors.lastname: Mwangi
mesh_terms: D000634:Aminoquinolines / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D001921:Brain / Q000473:pathology; D015511:Goat Diseases / Q000188:drug therapy* / Q000517:prevention & control; D006041:Goats; D051379:Mice; D008813:Mice, Inbred ICR; D014344:Trypanocidal Agents / Q000627:therapeutic use* / Q000633:toxicity; D014346:Trypanosoma brucei brucei; D014348:Trypanosoma congolense; D014353:Trypanosomiasis, African / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D000634:Aminoquinolines; D014344:Trypanocidal Agents; C041921:1,6-bis(6-amino-2-methyl-4-quinolylamino)hexane