[Changes in the reaction of rat bone tissue to hypokinesia after administration of hydroxymethyl aminopropylidene bisphosphonate].
During 35-day hypokinesia rat spongy bone in the tibia and vertebrae varied in two phases. The first phase (up to 15 days) was induced by a stress-reaction and the second phase by adaptation to hypokinesia. Under the influence of subcutaneous injections of hydroxydimethyl aminopropylidene biphosphonate (AMOK) at a dose of 0.01 mg/kg/day bone changes disappeared: throughout the study spongy bone mass remained as in controls. AMOK administration at a dose of 5 mg/kg/day 10 days prior to hypokinetic exposure did not eliminate its inhibitory effect although the initial bone mass was 1.5-2 times higher than in the controls. However at the adaptation phase (beginning with day 15) bone mass increased, reaching the baseline. This indicates a decline in bone sensitivity to muscle unloading. It is concluded that AMOK modifies bone responses to various hypokinetic factors.
Shvets
V N
VN
Pankova
A S
AS
Go'ldovskaia
M D
MD
Vnukova
Z E
ZE
D000818:Animals; D015519:Bone Density / Q000187:drug effects / Q000502:physiology*; D004164:Diphosphonates / Q000008:administration & dosage* / Q000494:pharmacology; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control*; D011602:Psychophysiologic Disorders / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology*; D013977:Tibia / Q000187:drug effects / Q000503:physiopathology; D013997:Time Factors
D004164:Diphosphonates; C055774:olpadronic acid
Izmenenie reaktsii kostnoĭ tkani krys na gipokineziiu pod vliianiem oksidimetilaminopropiliden bisfosfonata (AMOK).