Prognostic implication of sequential bone marrow cultures in the myelodysplastic syndromes.
Twenty-five patients with newly-diagnosed myelodysplastic syndromes were studied by the clonal culture method at least three times during the clinical course. Clinical outcomes of the patients were classified into: a stable disease (ten patients); subsequent leukemic transformation (eight patients) and nonleukemic death (seven patients). The growth of the marrow granulocyte-macrophage progenitors (CFU-GM) at the time of diagnosis was significantly related to the survival. In addition, sequential changes in the CFU-GM growth patterns correlated with the different clinical outcome of myelodysplastic syndromes patients.
Yoshida
Y
Y
Department of Medicine, Faculty of Medicine, Kyoto University, Japan.
Yoshida
C
C
Tohyama
K
K
Ohmori
S
S
Ohmori
M
M
Ueda
Y
Y
Taniguchi
Y
Y
Uchino
H
H
D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D005500:Follow-Up Studies; D006410:Hematopoiesis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies