title: The effect of methotrexate on the development of synapses in the neonatal rat hippocampus.
abstract: The effects of postnatal methotrexate (MTX) exposure on the development of synapses in the developing rat hippocampus were examined. The density of E-PTA-stained synaptic junctions per unit area was significantly reduced by MTX exposure either during day 1-5 or 6-10 post partum. It was suggested that administering MTX during the critical period affected the development of synapses in the developing rat brain.
authors.affiliation: Second Department of Anatomy, Toho University School of Medicine, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Igarashi
authors.forename: K
authors.initials: K
authors.lastname: Inomata
authors.forename: A
authors.initials: A
authors.lastname: Tateno
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000254:growth & development* / Q000648:ultrastructure; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D008727:Methotrexate