title: Experimental-scale measles and mumps vaccine production on microcarrier-grown cells.
abstract: Small-scale measles and mumps virus propagation in microcarrier-grown cells was studied to assess putative advantages over conventional roller-type virus propagation. Significantly higher virus yields could not be attained with microcarrier cultures in cell stirrers, therefore making the advantages purely technological. The pattern of measles virus production was slightly different for the three types of microcarriers used. Experimental measles and mumps vaccine lots obtained met vaccine quality control requirements.
authors.affiliation: Vaccine Production Department, Moscow, USSR.
authors.forename: E S
authors.initials: ES
authors.lastname: Sidorenko
authors.forename: L V
authors.initials: LV
authors.lastname: Dorofeeva
authors.forename: T I
authors.initials: TI
authors.lastname: Kaptsova
authors.forename: L L
authors.initials: LL
authors.lastname: Steinberg
authors.forename: I N
authors.initials: IN
authors.lastname: Zasorina
authors.forename: O A
authors.initials: OA
authors.lastname: Sinitsyna
authors.lastname: Boriskin YuS
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D008458:Measles Vaccine / Q000096:biosynthesis*; D008459:Measles virus / Q000254:growth & development; D009108:Mumps Vaccine / Q000096:biosynthesis*; D009109:Mumps virus / Q000254:growth & development; D011784:Quail
chemical_list: D008458:Measles Vaccine; D009108:Mumps Vaccine