[The age-related characteristics of the effect of vasopressin on the vascular smooth muscles of the human brain].
Vasopressin was shown to cause a concentration-dependent relaxation of human basilar [correction of bacillary] artery's smooth muscles. In old age, the reactivity of these muscles in decreased and tachyphylaxis to vasopressin disappeared. This seems to be connected with a decrease in the quantity of smooth muscle's V2-inhibitory receptors. Protein kinase C activation does not affect molecular mechanisms of vasopressin action on human basilar [correction of bacillary] artery's smooth muscles. The data obtained suggest vasopressin participation in regulation of human cerebral blood flow and a limitation of adaptive properties of brain vessels' smooth muscles in old age. These factors, apparently, play a role in development of the brain circulation pathology in old men.
Gurevich
M I
MI
Frol'kis
I V
IV
Kovalenko
T N
TN
Dibrova
V A
VA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000187:drug effects* / Q000502:physiology; D001488:Basilar Artery / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D001921:Brain / Q000098:blood supply / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins
Vozrastnye osobennosti vliianiia vazopressina na gladkie myshtsy sosudov mozga cheloveka.