title: Uptake of 14C-xylitol by xylitol-cultured Streptococcus sobrinus ATCC 27352 and Streptococcus mitis ATCC 36249 in vitro.
abstract: The effect of three successive cultures in the presence of 6% xylitol on the uptake of 14C-xylitol was studied using resting cells of Streptococcus sobrinus ATCC 27352 and Streptococcus mitis ATCC 36249. In the case of S. mitis, the three successive cultures did not alter the growth inhibition observed in the presence of xylitol. In the case of S. sobrinus, however, growth inhibition decreased. The 14C-xylitol uptake experiments also demonstrated that uptake of xylitol by S. sobrinus was decreased by culture in the presence of xylitol. Previous 14C-xylitol uptake levels were, however, re-established by culturing S. sobrinus in the presence of glucose alone. Culture in the presence of xylitol did not affect 14C-xylitol uptake in the case of S. mitis. These results show that S. sobrinus and S. mitis differ in the ways they handle of exogenous xylitol, and that uptake of xylitol by S. sobrinus could be reversibly regulated by addition xylitol to the growth medium.
authors.forename: A
authors.initials: A
authors.lastname: Pihlanto-Leppälä
authors.forename: E
authors.initials: E
authors.lastname: Söderling
authors.forename: K
authors.initials: K
authors.lastname: Mäkinen
mesh_terms: D002455:Cell Division / Q000187:drug effects; D006131:Growth Inhibitors; D013045:Species Specificity; D013291:Streptococcus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D014993:Xylitol / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D006131:Growth Inhibitors; D014993:Xylitol