title: Haemodynamic effects of respiratory alkalosis independent of changes in airway pressure in anaesthetized newborn dogs.
abstract: We have recently reported a decrease in cardiac output in newborn dogs during respiratory alkalosis which is independent of changes in airway pressure. The present study was designed to characterize the mechanism responsible for this reduction in cardiac output. Twelve newborn coonhounds were anaesthetized with pentobarbital, paralyzed with pancuronium and hyperventilated to an arterial carbon dioxide tension (PaCO2) of 20 torr. Subsequent changes in PaCO2 were achieved by altering the FiCO2. Measurements were made after 30 min at either 40 or 20 torr PaCO2. The sequence of PaCO2 levels was randomized. Compared to normocarbia, respiratory alkalosis resulted in significantly decreased cardiac output (279 +/- 16 to 222 +/- 10 ml/min per kg, mean +/- SEM, P less than 0.001), stroke volume (1.60 +/- 0.10 to 1.24 +/- 0.06 ml/kg; P less than 0.001), maximum left ventricular dP/dt (1629 +/- 108 to 1406 +/- 79 mmHg/s, P less than 0.01) and left ventricular end diastolic pressure (3.9 +/- 0.4 to 2.9 +/- 0.3 mmHg; P less than 0.001). The decrease in cardiac output during respiratory alkalosis is manifest through a decrease in stroke volume, which is due, at least in part, to the decrease in left ventricular end diastolic pressure. The decrease in maximum left ventricular dP/dt is likely a reflection of the decrease in preload, however, a change in myocardial contractility cannot be excluded. We speculate the decrease in filling pressure may be due to an increase in venous capacitance.
authors.affiliation: Department of Pediatrics, Children's Hospital Research Foundation, University of Cincinnati, Ohio 45267.
authors.forename: J H
authors.initials: JH
authors.lastname: Reuter
authors.forename: E F
authors.initials: EF
authors.lastname: Donovan
authors.forename: U R
authors.initials: UR
authors.lastname: Kotagal
mesh_terms: D000472:Alkalosis, Respiratory / Q000150:complications / Q000503:physiopathology*; D000771:Anesthesia, Intravenous; D000818:Animals; D000831:Animals, Newborn; D001784:Blood Gas Analysis; D002303:Cardiac Output, Low / Q000209:etiology; D004285:Dogs; D006339:Heart Rate; D006439:Hemodynamics; D013318:Stroke Volume