Evaluation of renal function before and after intravenous injection of uroangiographic water soluble contrast media in men.
Nephrotoxicity due to injection of uro-angiographic water soluble contrast media is a wellknown hazard in patients with renal failure, diabetes mellitus, cardiovascular disease, multiple myeloma and old age. Cases of nephrotoxicity in other patient populations are extremely rare. In order to document the influence of water soluble contrast media in patient undergoing intravenous urography diuresis, osmolar changes, creatinine clearance, absolute urinary creatinine excretion and uric acid metabolism were evaluated before and after contrast medium injection. No adverse reaction could be evidenced as far as the renal function is concerned, as creatinine clearance and absolute urinary creatinine output values showed no significant differences. The significant raise (p less than or equal to 0.001) of uric acid excretion (absolute urinary uric acid excretion values before and after contrast injection were respectively 5.22 micrograms/min.kg (IR: 3.24) and 10.68 micrograms/min.kg (IR: 4.03] can be co-responsible for adverse reactions when the renal function is not normal.
Verbaeys
A
A
Lameire
N
N
Oosterlinck
W
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000792:Angiography / Q000009:adverse effects; D003287:Contrast Media / Q000009:adverse effects; D003404:Creatinine / Q000032:analysis; D004231:Diuresis / Q000187:drug effects; D006801:Humans; D007482:Iothalamate Meglumine / Q000009:adverse effects*; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D007668:Kidney / Q000187:drug effects*; D008875:Middle Aged; D009994:Osmolar Concentration; D014527:Uric Acid / Q000009:adverse effects; D014567:Urography / Q000009:adverse effects
D003287:Contrast Media; D007483:Iothalamic Acid; D014527:Uric Acid; C002587:ioxitalamic acid; D003404:Creatinine; D007482:Iothalamate Meglumine