title: Benzene in the blood and breath of normal people and occupationally exposed workers.
abstract: Benzene was measured in blood and alveolar air of 168 men, aged 20-58 years, subdivided into four groups: blood donors, hospital staff, chemical workers occupationally exposed to benzene, and chemical workers not occupationally exposed to benzene. The group of exposed workers was employed in work places with a mean environmental exposure to benzene of 1.62 mg/M3 (8 hr TWA). Non-exposed workers were employed elsewhere in the same plant, with an environmental exposure to benzene lower than 0.1 mg/M3. Blood and alveolar air samples were collected in the morning, before the start of the work shift for the chemical workers. The group of exposed workers was found to be significantly different from the other three groups, both for blood and alveolar benzene concentrations. The mean blood benzene concentration was 789 ng/l in the exposed workers, 307 ng/l in the non-exposed workers, 332 ng/l in the hospital staff, and 196 ng/l in the blood donors. Apart from the exposed workers, blood benzene concentration was significantly higher in smokers than in non-smokers. The mean alveolar benzene concentration was 92 ng/l in the exposed workers, 42 ng/l in the non-exposed workers, 22 ng/l in the hospital staff, and 11 ng/l in the blood donors. Alveolar benzene concentration was significantly higher in smokers than in non-smokers in the groups of the hospital staff and non-exposed workers, but not in the blood donors and exposed workers. In the three groups without occupational exposure considered altogether, the alveolar benzene concentration correlated significantly with environmental benzene concentration measured at the moment of the individual examinations, both in the smokers (r = .636; p less than .001) and non-smokers (r = .628; p less than .001). In the same three groups and in the exposed workers, alveolar benzene concentration showed a significant correlation with the blood benzene concentration.
authors.affiliation: Istituto di Medicina del Lavoro, Università di Verona, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Brugnone
authors.forename: L
authors.initials: L
authors.lastname: Perbellini
authors.forename: G B
authors.initials: GB
authors.lastname: Faccini
authors.forename: F
authors.initials: F
authors.lastname: Pasini
authors.forename: B
authors.initials: B
authors.lastname: Danzi
authors.forename: G
authors.initials: G
authors.lastname: Maranelli
authors.forename: L
authors.initials: L
authors.lastname: Romeo
authors.forename: M
authors.initials: M
authors.lastname: Gobbi
authors.forename: A
authors.initials: A
authors.lastname: Zedde
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis*; D001554:Benzene / Q000032:analysis*; D002617:Chemical Industry; D004781:Environmental Exposure; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli; D012907:Smoking / Q000009:adverse effects
chemical_list: D000395:Air Pollutants, Occupational; D001554:Benzene