[The antibiotic effect of Pseudomonas jinanensis sp. nov].
The Pseudomonas jinanensis has been isolated from soil and screened by antibioticgram assay and spermatogonial assay. It has certain antibiotic properties. The metabolite which has been produced is certainly effective against Staphylococcus aureus and some other positive germs. The preparation of Pseudomonas jinanensis vaccine, namely PJV. It's biological activity on the growth of tumor-bearing mice and the murine spermatogenesis cell. It is considered that enhancement of nonspecific immunologic function of the host might increase the efficacy of praziquantel on schistosomiasis in mice. PJV has certainly produced effectiveness against malignant pleural effusion (effective rate was 76.5%), cancer of lung (effective rate was 58.3%), many solid kinds of cancer (effective rate was 52.1%), and the total effective rate was 64.2%. It could increase the sensitivity of cancer cells to radiation. PJV could stimulate the animal (rabbit) to develop specific antibody. PJV might belong to the class of immunomodulating agents.
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D000818:Animals; D000900:Anti-Bacterial Agents; D001428:Bacterial Vaccines / Q000494:pharmacology; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D011549:Pseudomonas / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D001428:Bacterial Vaccines