title: [Heparin-induced skin necrosis, thrombocytopenia and pulmonary thromboembolism. Presentation of 2 cases].
abstract: Two patients with skin necrosis in the injection points after subcutaneous prophylactic porcine calcium heparin administration are reported. In addition, both patients had thrombopenia, deep venous thrombosis and pulmonary thromboembolism. The review of similar cases suggests that skin necrosis is another feature of the thrombopenia and multiple vascular thrombosis syndrome associated with heparin administration. Data from the literature suggest that there is a common immunologically-mediated pathogenetic mechanism responsible for these phenomena through the production of platelet aggregates and immune reaction in endothelial cells. Paradoxically, the continuation of therapy with intravenous sodium heparin was not followed in our patients by new complications despite the theoretical risk.
authors.forename: R
authors.initials: R
authors.lastname: Armengol
authors.forename: J
authors.initials: J
authors.lastname: Moré
authors.forename: J
authors.initials: J
authors.lastname: Garau
mesh_terms: D000328:Adult; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007279:Injections, Subcutaneous / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011655:Pulmonary Embolism / Q000139:chemically induced*; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: C006871:calcium heparin; D006493:Heparin
vernacular_title: Necrosis cutánea por heparina, trombocitopenia y tromboembolismo pulmonar. Presentación de 2 casos.