Intraerythrocytic water relaxation rates in amyotrophic lateral sclerosis. An NMR investigation.
Water relaxation rates 1/T2 in erythrocytes from amyotrophic lateral sclerosis (ALS) patients were studied by NMR. The spin-spin relaxation time of water protons in erythrocyte suspension was measured in the presence of a paramagnetic reagent which did not enter the cell. Our results show that red blood cell membranes exhibit a diminished water permeability in some ALS patients. Moreover, the activation energy value of water is lower in ALS patients than in healthy controls.
Monti
J P
JP
Laboratoire de Biophysique, Faculté de Pharmacie, Marseille, France.
Braguer
D
D
Guelton
C
C
Crevat
A
A
Serratrice
G
G
D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood*; D002463:Cell Membrane Permeability / Q000502:physiology*; D004910:Erythrocyte Membrane / Q000502:physiology*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D013816:Thermodynamics; D014867:Water / Q000378:metabolism*
D014867:Water