title: [Quantitative characterization of nuclear polymorphism of the epithelial cells in fibroadenomatosis and cancer of the breast].
abstract: A method for quantitative analysis of epithelial cell nuclear polymorphism was suggested, viz. identification of general statistical population using Petunin's criterion. This criterion was employed to assess heterogeneity of visible surface of interphase epithelial cell nuclei and to assay nuclear DNA level in fibroadenomatous hyperplasia and cancer of the breast. Heterogeneity index (h), alongside with other parameters, appeared useful for quantitative assessment of the disease: heterogeneity index values ranging 0.1-0.4 point to pronounced heterogeneity of epithelial cell nucleus surface and DNA level, and are suggestive of malignant transformation of tissue, whereas benign proliferation of the epithelium is usually characterized by 0.4 less than h less than or equal to 0.9.
authors.forename: K P
authors.initials: KP
authors.lastname: Ganina
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Petunin
authors.forename: Ia G
authors.initials: IaG
authors.lastname: Timoshenko
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D000232:Adenofibroma / Q000175:diagnosis*; D001943:Breast Neoplasms / Q000175:diagnosis*; D002277:Carcinoma / Q000175:diagnosis*; D002467:Cell Nucleus; D004273:DNA, Neoplasm / Q000032:analysis*; D003937:Diagnosis, Differential; D004847:Epithelial Cells; D005260:Female; D006801:Humans; D007399:Interphase; D011110:Polymorphism, Genetic
chemical_list: D004273:DNA, Neoplasm
vernacular_title: Kolichestvennaia kharakteristika iadernogo polimorfizma épitlial'nykh kletok pri fibroadenomatoze i rake molochnogo zhelezy.