Isolation of flavonoids from Populus nigra as delta 4-3-ketosteroid (5 alpha) reductase inhibitors.
Inhibitors of delta 4-3-ketosteroid (5 alpha) reductase, which had been prepared from rat prostate and converted testosterone to 5 alpha-dihydrotestosterone and 4-androstene-3,17-dione, were isolated from 50% ethanol extract of Populus nigra. They were identified as pinobanksin (I, 3,5,7-trihydroxyflavanone), 3,7-dimethylquercetin (II, 3',4',5-trihydroxy-3,7-dimethoxyflavone) and pinocembrin (III, 5,7-dihydroxyflavanone). Compound III showed the most potent inhibitory activity among them.
Komoda
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D058891:5-alpha Reductase Inhibitors; D000818:Animals; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D010944:Plants / Q000032:analysis*; D011467:Prostate / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D058891:5-alpha Reductase Inhibitors; D005419:Flavonoids