Studies on hypolipidemic agents. IV. 3-[4-(Phenylthio)benzoyl]propionic acid derivatives.
2-Acetylthio-3-benzoylpropionic acid derivatives having two benzene rings or condensed-ring moieties were prepared, and tested for hypolipidemic activity in normal rats. Some of these compounds were active. 2-Acetylthio-3-[4-(phenylthio)benzoyl]propionic acid (10) and its derivatives seemed to have the most potent hypocholesterolemic activities. Compound 10 showed strong activity, especially in cholesterol-fed rats.
Kameo
K
K
Asami
Y
Y
Ogawa
K
K
Matsunaga
T
T
Saito
S
S
Tomisawa
K
K
Sota
K
K
D000818:Animals; D001565:Benzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D008297:Male; D051381:Rats; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D001565:Benzoates; D000960:Hypolipidemic Agents; D013438:Sulfhydryl Compounds