Prognostic factors in colorectal carcinoma: significance of peripheral T lymphocytes.
An analysis was made of a consecutive series of 150 patients with colorectal carcinoma treated in Shinkokura Hospital from 1973 to 1987. The prognostic factors included resection or nonresection, the year of resection, macroscopic type, histologic differentiation, venous and lymphatic invasion, Dukes' stage, serum carcinoembryonic antigen (CEA) level and peripheral T lymphocyte count. CEA, T lymphocytes and B lymphocytes were studied clinically and immunohistochemically. Clinical and immunohistochemical data on T lymphocytes were obtainable for 24 patients. Seventeen of the 24 were of more than 1000/mm3 of preoperative peripheral T lymphocytes and consisted of seven dense, six moderate and four slight immunohistochemical types, while the remaining seven were of less than 1000/mm3 of T lymphocytes and comprised one dense, two moderate and four slight ones. One-year survival rates of slight (8), moderate (8) and dense (8) types were 60%, 90% and 94%, respectively, and three-year survivals were 42%, 57%, and 76% (p less than 0.05). We suggest that the immunohistochemical demonstration of T lymphocytes relates to the peripheral T lymphocyte count and is one sign of an early, good prognosis for patient with colorectal carcinoma.
Yamaguchi
K
K
Department of Surgery, Shinkokura Hospital, Kitakyushu, Japan.
Maeda
S
S
Kitamura
K
K
D002272:Carcinoembryonic Antigen / Q000097:blood / Q000276:immunology*; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000473:pathology; D006801:Humans; D011379:Prognosis; D013601:T-Lymphocytes / Q000276:immunology*
D002272:Carcinoembryonic Antigen