[Estimation of the critical level of an arrest in differentiation of human hematopoietic stem cells].
On the basis of the analysis of postirradiation changes in the specific number human peripheral blood neutrophils the authors have estimated the level of the "arrest of differentiation" (AD) of their precursors (haemopoietic stem cells (HSC) which amounted to 0.2-0.9% of their normal number at a local functional site of haemopoiesis. The time of the onset of AD, with subcritical doses (to 6.4-8.8 Gy) leading to HSC pool depletion, which does not reach a critical level, decreases linearly with dose, and its duration is practically independent of the dose and makes up 10 (6 to 16) days on an average.
Solov'ev
V Iu
VIu
Baranov
A E
AE
D002454:Cell Differentiation / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D006801:Humans; D009504:Neutrophils / Q000528:radiation effects*; D013997:Time Factors
Otsenka kriticheskogo urovnia "zapreta na differentsirovku" chislennosti stvolovykh krovetvornykh kletok cheloveka.