[The morphogenesis of the structural changes of the exocrine pancreas after ligation of the excretory duct].
The changes in the exocrine pancreas were investigated after ligature of the excretory duct in 51 Wistar rats. A qualitative microdetermination of the epithelial cells was carried out in the originated ductulus-like structures.


CONCLUSIONS
The acinic epithelial cells grow atrophically first of all and become necrotic in the end. A dedifferentiated acinic cellular atrophy with metamorphosis to a ductulus-like cell type could not be observed. Proliferative and preproliferative events occur in the duct epithelial cells. Cystic ductulus-like structures originated from this. These fill out the former acinic areas by immature, few differentiated, pluripotent epithelial cells that look similar to embryonal pancreatic cells.
Rohrbeck
R
R
Klinik für Chirurgie, Wilhelm-Píeck-Universität und dem Bezirkskrankenhaus, Rostock.
Rohrbeck
C M
CM
Putzke
H P
HP
Jonas
L
L
Reding
R
R
D000818:Animals; D001284:Atrophy; D008026:Ligation; D008297:Male; D009336:Necrosis; D010179:Pancreas / Q000473:pathology*; D010183:Pancreatic Ducts / Q000601:surgery*; D051381:Rats; D011919:Rats, Inbred Strains
Zur Morphogenese des Strukturwandels des exokrinen Pankreas nach Ausführungsgangligatur.