[Protective effect rendered by human ceruloplasmin on erythrocytes in hepatocerebral dystrophy].
In order to elucidate the protective effect of human ceruloplasmin (CP) on erythrocytes in patients with hepatocerebral dystrophy (HCD), the parameters reflecting the interaction of CP from the blood of healthy donors (n-CP) and of HCD patients (h-CP) with erythrocytes from healthy donors (n-ER) and from HCD patients (h-ER) were estimated. The protective effects of n-CP and h-CP on n-ER and h-ER during the Cu2+-induced lysis were compared. It was shown that the ability of h-CP to prevent the human ER breakdown upon Cu2+-induced lysis is much lower (approximately 3-fold) than that of n-CP. The differences in the protective effect of n-CP and h-CP are manifested in a greater degree during the n-ER lysis than during the h-ER lysis.
Saenko
E L
EL
Skorobogat'ko
O V
OV
Mzhel'skaia
T I
TI
Ivanova-Smolenskaia
I A
IA
Markova
E D
ED
Basevich
V V
VV
D002570:Ceruloplasmin / Q000378:metabolism*; D003300:Copper / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism* / Q000473:pathology; D006461:Hemolysis; D006527:Hepatolenticular Degeneration / Q000378:metabolism*; D006801:Humans
D003300:Copper; D002570:Ceruloplasmin
Zashchitnoe deĭstvie, okazyvaemoe tseruloplazminom chekoveka na éritrotsity pri gepatotserebral'noĭ distrofii.