[Comparison of relay neurons in the lateral geniculate body of normal, bilaterally enucleated and congenitally blind strain 944 mice during ontogenesis].
Mice with normal visus, bilaterally enucleated and congenitally blind mice of the strain 944 were used to determine following parameters in the CGLd on day 5, 10, 15 and 20 post natum (Golgi impregnation): size of neurons (perikarya, size of dendritic domains DF), structure of dendrites (number of dendrites FDE, branching points VZP, distribution of dendritic density in relation to the perikaryon Is, number of primary dendrites). After Nissl staining the following parameters were investigated: volume of the CGLd, packing density and total number of cells in the CGLd. The differences between the three investigated groups of animals increase in changing amounts during the ontogenesis. The caudal part of the CGLd is altered mostly by the lacking optic events. Suppression of visual events during the normal ontogenesis caused by genetic defect or enucleation attacks the same structures of the neuron.
Hilbig
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Paul-Flechsig-Institut für Hirnforschung der Karl-Marx-Universität Leipzig.
Winkelmann
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D000375:Aging / Q000473:pathology*; D000818:Animals; D001766:Blindness / Q000151:congenital / Q000473:pathology*; D002452:Cell Count; D015353:Eye Enucleation; D005829:Geniculate Bodies / Q000166:cytology / Q000254:growth & development / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains
Vergleich der Relais-Neuronen im Corpus geniculatum laterale Pars dorsalis (CGLd) von normalen, bilateral enucleirten und kongenital blinden Mäusen des Stammes 944 während der Ontogenese.