[Effects of bis(dimethyl amino)-diphenyl methane (BDDM) on action potentials in guinea pig papillary muscle].
The effects of BDDM on action potentials and slow response action potentials in guinea pig papillary muscle were investigated by microelectrode technique. BDDM prolonged action potentials duration at 30, 50, 90, and 100% repolarization (APD30, APD50, APD90, APD100) and prolonged the effective refractory period (ERP), so ERP/APD value became greater. BDDM (51.6 mumol/L) decreased the APA, Vmax and prolonged APD50, APD90. In barium-induced ventricular autorhythmicity, BDDM suppressed the maximal diastolic potential (MDP), APA and reduced the rate of spontaneous rhythm. The results suggest that BDDM may unspecifically inhibit the currents of Ca2+, K+, and Na+.
Liu
D Q
DQ
Zhao
D H
DH
Sheng
B H
BH
D000200:Action Potentials / Q000187:drug effects; D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D008839:Microelectrodes; D010210:Papillary Muscles / Q000187:drug effects* / Q000502:physiology
D000814:Aniline Compounds; D000889:Anti-Arrhythmia Agents; C035472:N,N,N',N'-tetramethyl-4,4'-methylenedianiline