Tubular reabsorption of protein by porcine kidneys during neonatal alimentary proteinuria.
The ability of renal proximal tubular cells to reabsorb protein early in postnatal life was investigated using goat haemoglobin as tracer. The haemoglobin was intracardially administered to newborn piglets. The kidneys were fixed for light and electron microscopy 4 h later. Piglets killed immediately after birth and those allowed to suck colostrum for 4 h were used as controls. The proximal tubular cells of newborn, unsuckled piglets already contained absorptive vacuoles. Haemoglobin was absorbed in some absorptive vacuoles of the proximal tubules. The tracer was also demonstrable in the urine, mainly in the form of methaemoglobin. Although proximal tubular cells of newborn piglets are able to absorb protein, this absorption is of limited extent and excess protein is voided with the urine.
Baintner
K
K
Kerényi
T
T
Cséplö
A
A
D000042:Absorption; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D007684:Kidney Tubules / Q000378:metabolism*; D008297:Male; D011506:Proteins / Q000378:metabolism*; D011507:Proteinuria / Q000378:metabolism / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000378:metabolism*
D011506:Proteins