Interleukin-1 production by human monocytes in ageing and disease.
Interleukin-1 mediates the febrile response which is often said to be reduced in the elderly. Interleukin-1 production by monocytes cultured in vitro and stimulated with bacterial lipopolysaccharide was measured. Three groups of subjects were studied; 40 normal young, 33 well elderly and 40 elderly with a history of repeated infection. No difference in interleukin-1 secretion was found between the groups. When the group with recurrent infection was subdivided into those with a history of fever and those with no record of fever accompanying their infection, the group without fever produced significantly less interleukin-1 (p = 0.035).
Rudd
A G
AG
Department of Geriatric Medicine, St. George's Hospital Medical School, London.
Banerjee
D K
DK
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D002478:Cells, Cultured; D005260:Female; D005334:Fever / Q000097:blood*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D012189:Retrospective Studies
D007375:Interleukin-1