title: [Development of immunologic deficiency conditions and sensitization in industrial workers and methodologic approach to their detection and evaluation].
abstract: The principal mechanisms forming the basis of detoxication abnormalities have been analysed using the data of research into the status of the hepatic monooxygenase enzyme system, which is responsible for the liver detoxication potential, and the literature reports. Irrespective of the pathology, a similar depression of the monooxygenase enzyme system of hepatocytes was revealed in acute stercoraceous peritonitis, acute ileus, burn disease, acute renal failure, and pyo-inflammatory conditions in the maxillofacial region. A pathogenetic model is proposed, which explains the mechanism of hepatic detoxication dysfunction in endogenous intoxications of different etiology. New approaches to the therapy of detoxication abnormalities in the conditions attended with endotoxemic syndrome are discussed proceeding from the pathogenetic mechanisms.
authors.forename: L A
authors.initials: LA
authors.lastname: Dueva
authors.forename: L A
authors.initials: LA
authors.lastname: Ivanova
authors.forename: T A
authors.initials: TA
authors.lastname: Pavlova
mesh_terms: D002728:Chlorohydrins / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000150:complications* / Q000175:diagnosis; D004811:Epichlorohydrin / Q000009:adverse effects*; D004853:Epoxy Resins / Q000009:adverse effects*; D005557:Formaldehyde / Q000009:adverse effects*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced* / Q000175:diagnosis; D007159:Immunologic Tests; D008669:Metallurgy; D009784:Occupational Diseases / Q000139:chemically induced*; D014586:USSR
chemical_list: D002728:Chlorohydrins; D004853:Epoxy Resins; D004811:Epichlorohydrin; D005557:Formaldehyde
vernacular_title: Formirovanie u promyshlennykh rabochikh immunodefitsitnykh sostoianiĭ i sensibilizatsii i metodicheskie podkhody k ikh vyiavleniiu i otsenke.