[A morphologic analysis of changes in the lungs and kidneys caused by acetyl glyceryl ether phosphorylcholine and limited by verapamil].
Histological analysis of lung and kidney after multiple PAF i.v. injection into rabbits was performed. Under these conditions the effect of previously injected of verapamyl, calcium channel blocker, was studied. It was shown that RAF causes inflammatory reaction with cell infiltration, microcirculation disorders and thrombosis in lung and kidney, which may classify as interstitial nephritis, pneumonitis and vasculitis. Verapamyl inhibits vasospasm, abolishes fibrinogen but does not affect cell infiltration and oedema development. Thus, Ca channel-dependent mechanism of vasospasm and thrombogenesis induced by PAF in vivo is confirmed. Perhaps, another possibilities for realising PAF action in vivo may occur.
Svetlov
S I
SI
Burova
V Ia
VIa
Kleĭmenova
N V
NV
Brydun
A V
AV
Serebrianyĭ
V L
VL
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008168:Lung / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000473:pathology; D010972:Platelet Activating Factor / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology*
D010972:Platelet Activating Factor; D014700:Verapamil
Morfologicheskiĭ analiz izmeneniĭ v legkikh i pochkakh, vyzvannykh atsetilglitseril'nym éfirom fosforilkholina i ogranichennykh verapamilom.