title: Clinical pharmacology of sedatives and opioid analgesics, Part I.
abstract: This two-part article reviews the human pharmacology of two classes of pharmacologic agents: sedative-hypnotics and opioid (narcotic) analgesics. The major emphasis is on the injectable drugs that play a central role in contemporary anesthesiology. In this issue, Part I addresses the pharmacokinetics of intravenous anesthetics and the clinical pharmacology of sedative-hypnotics. In the next issue, Part II will discuss the clinical pharmacology of opioid agonists.
authors.forename: P J
authors.initials: PJ
authors.lastname: Desjardins
mesh_terms: D000771:Anesthesia, Intravenous; D003975:Diazepam / Q000494:pharmacology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008723:Methohexital / Q000494:pharmacology; D008874:Midazolam / Q000494:pharmacology
chemical_list: D006993:Hypnotics and Sedatives; D008723:Methohexital; D003975:Diazepam; D008874:Midazolam