Pre-morbid psychopathology in schizophrenia spectrum.
In a prospective, longitudinal study of high-risk offspring of schizophrenic mothers, of several dimensions of pre-morbid behaviour 'peculiarity' predicted subsequent schizophrenia or schizotypy. Peculiarity/eccentricity may represent a subtle marker of the schizophrenic genotype. 'Pre-schizophrenics', as compared with 'pre-schizotypes', were characterised by affective dyscontrol, reflected in less introverted and more disturbed behaviour.
Parnas
J
J
University Department of Psychiatry, Kommunehospitalet, Copenhagen, Denmark.
Jorgensen
A
A
D000293:Adolescent; D000328:Adult; D002653:Child Behavior Disorders / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D007439:Introversion, Psychological; D010260:Paranoid Personality Disorder / Q000175:diagnosis; D011446:Prospective Studies; D012307:Risk Factors; D012557:Schizoid Personality Disorder / Q000175:diagnosis; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis