[The functional activity and count of the natural killer cells in patients with recently diagnosed diabetes mellitus types I and II].
Eight patients with type I diabetes mellitus (D-I), seven patients with type II diabetes mellitus (D-11) and 8 healthy donors were examined. The disease standing did not exceed 1 year since the moment of the diagnosis establishment. The patients with D-I manifested activation of natural killers (NK) as compared to their activity in the donors and patients with D-II (76.05 +/- 6.5%, 52.33 +/- 9.55% and 55.39 +/- 10.63%, respectively, p less than 0.01) in the presence of the attenuated response of NK to interleukin-2 and alpha-interferon, determined by NK prestimulation. The amount of NK (CD16-positive) in D-I was significantly less than in the donors and patients with D-II. The high activity of NK in D-I correlated with an increase of receptor expression for transferrin on the mononuclear cells of peripheral blood. At the same time 5 out of the 8 patients with D-I and 2 patients with D-II out of the 7 demonstrated the rise of serum alpha-interferon (in the titer 1:40 and over). Activation of NK and the rise of serum interferon may be due to viral etiology of the disease and may play a role in the autoimmune process in patients suffering from D-I.
Salozhin
K V
KV
Sura
V V
VV
Nasonov
E L
EL
Korneeva
M N
MN
Smirnova
O I
OI
D000293:Adolescent; D000328:Adult; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000276:immunology*; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000494:pharmacology; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology
D007370:Interferon Type I; D007376:Interleukin-2; D011994:Recombinant Proteins
Izuchenie funktsional'noĭ aktivnosti i kolichestva estestvennykh kletok-killerov u bol'nykh s nedavno voznikshim sakharnym diabetom I i II tipa.