title: Selenium toxicosis in three California sea lions (Zalophus californianus).
abstract: Selenium poisoning occurs worldwide in nearly all domestic animals. Acute selenium poisoning is associated with feeding high levels or injecting excessive amounts of selenium and is usually fatal. The acute poisoning may cause gastrointestinal disturbance, muscle weakness, depression of the central nervous system, prostration and death (1-2). Chronic selenium poisoning in cattle, sheep and horses may result from the consumption of seleniferous plants over an extended period of time. Chronic selenium results in ataxia, incoordination, partial blindness, paralysis, loss of hair or wool, abnormal hoof growth and possibly abnormal changes in behavior (1). There is little information regarding the clinical signs and pathology of selenium toxicosis in marine mammals. Likewise, there is little information regarding normal tissue levels or toxicologically significant levels of selenium in these species. The results of these investigations in sea lions, based on clinical signs, pathologic findings and tissue levels of selenium, suggest subacute or chronic selenium poisoning was most likely from dietary fish high in selenium.
authors.affiliation: College of Veterinary Medicine, Oklahoma State University, Stillwater 74078.
authors.forename: W C
authors.initials: WC
authors.lastname: Edwards
authors.forename: D L
authors.initials: DL
authors.lastname: Whitenack
authors.forename: J W
authors.initials: JW
authors.lastname: Alexander
authors.forename: M A
authors.initials: MA
authors.lastname: Solangi
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D010872:Caniformia; D005399:Fishes / Q000378:metabolism; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008168:Lung / Q000473:pathology; D008297:Male; D008670:Metals / Q000032:analysis; D046070:Sea Lions; D012643:Selenium / Q000032:analysis / Q000506:poisoning*; D013054:Spectrophotometry, Atomic; D013270:Stomach / Q000473:pathology
chemical_list: D008670:Metals; D012643:Selenium