Effect of 3-methyl-branching on the myocardial retention of radioiodinated 19-iodo-18-nonadecenoic acid analogues.
The effect of methyl-branching at the 3(beta-)-position on myocardial uptake and retention of fatty acids where radioiodide has been stabilized as a terminal trans-(E)-vinyl iodide has been evaluated in fasted rats. The syntheses of two new dimethyl-branched fatty acids, 17-iodo-3,3-dimethylheptadecanoic acid (14) and (E)-19-iodo-3,3-dimethyl-18-nonadecenoic acid (19), are described. Tissue distribution studies in fasted rats with [125I]-19 showed significant heart uptake (2 min, 4.56% dose/g), and prolonged retention (60 min 4.10% dose-g). These results suggest that [123I]-19 is a good candidate for further studies of regional myocardial fatty acid uptake patterns by SPECT.
Goodman
M M
MM
Health and Safety Research Division, Oak Ridge National Laboratory, TN 37831.
Neff
K H
KH
Ambrose
K R
KR
Knapp
F F
FF
D000818:Animals; D005227:Fatty Acids / Q000493:pharmacokinetics*; D005231:Fatty Acids, Unsaturated / Q000493:pharmacokinetics*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D009206:Myocardium / Q000378:metabolism*; D011877:Radionuclide Imaging; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution
D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D007457:Iodine Radioisotopes; C054608:19-iodo-3,3-dimethyl-18-nonadecenoic acid; C063043:17-iodo-3,3-dimethylheptadecanoic acid