[Study of a high molecular copolymer HFMC in vaginal irrigation for contraception in mice].
A vaginal spermicide of high molecular copolymer, ethyl methacrylate-methacrylic acid-hydroxyethyl methacrylate (HFMC), was introduced through a small tube into the mouse's vagina and made to adhere to it's wall, causing a pH alteration in the vaginal environment. Matching experiments showed that the sperms were killed or/and lost their mobility and vitality owing to the infertile acidic environment. The fertility could be restored when the HFMC dissolved gradually. But the delivering time was delayed for about 112-118 days versus the control (P less than 0.001). The fertility could also be restored artificially by flushing out the copolymer with solvent DMSO. In this case the delivering time was consistent with the control (P greater than 0.05).
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D000179:Acrylates / Q000008:administration & dosage*; D000282:Administration, Intravaginal; D000818:Animals; D005260:Female; D005298:Fertility / Q000187:drug effects; D008689:Methacrylates / Q000008:administration & dosage*; D051379:Mice; D011109:Polymethacrylic Acids / Q000008:administration & dosage*; D013089:Spermatocidal Agents / Q000008:administration & dosage*
D000179:Acrylates; D008689:Methacrylates; D011109:Polymethacrylic Acids; D013089:Spermatocidal Agents; C063229:hydroxyethyl methacrylate-methacrylic acid-ethyl methacrylate copolymer