[The artificial heart from the aspect of results thus far and from the aspect of further perspectives for research and clinical practice].
The author gives an account of the present position in the development of research of artificial hearts and mechanical support whereby special attention is paid to research in the CSSR which holds one of the foremost places in the world. When resolving some basic questions of long-term biological adaptation to the activity of the mechanical system, i.e. the artificial heart, this research becomes very important as a unique model for investigation of the isolated peripheral circulation the reactions of which are not affected by the action of the biological heart which has been eliminated. Moreover, specific conditions are created for the investigation of other general biologically important problems (hormonal regulation, metabolic factors, leading to calcification of biomaterials and its prevention, problems of dynamics of the coagulation system, thrombogenesis etc.) in the organism with an artificial heart. At present there are essentially two methods suitable for clinical application, i.e. mechanical support of the heart of the type of mono- or biventricular bypass with total replacement of the heart as a temporary operation before subsequent transplantation. Both these methods are promising. Further intensive research of the long-term survival of subjects with an artificial heart creates in addition to typical features of fundamental research the basis for permanent implantation of an artificial heart in clinical work which is another important stage of clinical applications.
Vasků
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D000818:Animals; D006354:Heart, Artificial / Q000009:adverse effects; D006801:Humans; D012106:Research
Umĕlé srdce z hlediska dosavadních dosazených výsledků i z hlediska jeho dalsích perspektiv ve výzkumu a klinice.