title: [Determination of the activity of neurotoxic esterase in the peripheral blood lymphocytes for assessing the action of organophosphorus compounds].
abstract: It was shown on a model of intoxication of hens with aphos possessing a selective neuroparalytic action that the target-enzyme neurotoxic esterase changed its activity in the brain, spleen and lymphocytes of the peripheral blood. The authors describe a method of determination of the activity of neurotoxic esterase in human peripheral blood lymphocytes that may be used for biomonitoring of the effect of phosphorus organic compounds possessing a delayed neurotoxic action.
authors.forename: I I
authors.initials: II
authors.lastname: Tkachenko
authors.forename: N V
authors.initials: NV
authors.lastname: Kokshareva
authors.forename: D V
authors.initials: DV
authors.lastname: Zinchenko
authors.forename: M L
authors.initials: ML
authors.lastname: Zinov'eva
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Kagan
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors / Q000097:blood*; D002645:Chickens; D005260:Female; D006801:Humans; D007306:Insecticides / Q000633:toxicity*; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology; D009943:Organophosphorus Compounds / Q000633:toxicity; D013154:Spleen / Q000187:drug effects / Q000201:enzymology
chemical_list: D007306:Insecticides; D009943:Organophosphorus Compounds; C034223:aphos; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase
vernacular_title: Opredelenie aktivnosti neĭrotoksicheskoĭ ésterazy v limfotsitakh perifericheskoĭ krovi dlia otsenki deĭstviia fosfororganicheskikh soedineniĭ.