Serum fatty acid proportions in retinitis pigmentosa may be affected by a number of factors.
Variations in serum fatty acid (FA) proportions of 67 Retinitis pigmentosa patients suggested a consideration of other factors which might affect these values. Serum FA, particularly arachidonic acid, may be altered during immunoregulatory substance formation in addition to genetic and dietary controls. Parallel immune system studies of these patients showed FA patterns consistent with increased prostaglandin-mediated (PG) lymphocyte suppression in 27% and possible block of PG immunoregulation in another 37%. While differences found between total serum FA of RP patients and age-matched normals included lower 18:2 omega 6 and higher 22:6 omega 3, the dominant and recessive RP patients showed similar proportion. However, lower than normal 22:6 omega 3 was found in 7 Usher RP.
Williams
L L
LL
Department of Pediatrics, Ohio State University College of Medicine, Columbus 43205.
Horrocks
L A
LA
Leguire
L E
LE
Shannon
B T
BT
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D001095:Arachidonic Acids / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005227:Fatty Acids / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D012174:Retinitis Pigmentosa / Q000097:blood* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000914:Antibodies, Viral; D001095:Arachidonic Acids; D005227:Fatty Acids; D010743:Phospholipids