[The effect of proteinase inhibitors on the level of degradation and unscheduled synthesis of DNA in ultraviolet- and gamma-irradiated cellsof mouse ascitic carcinoma].
Proteinase inhibitors (e.g. antipain, pepstatin A, and phenylmethane sulfonyl fluoride) were shown to decrease the rate of incision DNA degradation and the level of unscheduled synthesis of DNA in Ehrlich ascites tumor cells exposed to UV-light and gamma-radiation. The results obtained indicate that nuclear proteinases are involved in regulation of DNA repair process.
Zakrzhevskaia
D T
DT
Gaziev
A I
AI
D000818:Animals; D000976:Antipain / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D002588:Cesium Radioisotopes; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D004273:DNA, Neoplasm / Q000187:drug effects* / Q000528:radiation effects; D005720:Gamma Rays; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D010436:Pepstatins / Q000494:pharmacology; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology*; D014466:Ultraviolet Rays
D002588:Cesium Radioisotopes; D004273:DNA, Neoplasm; D010436:Pepstatins; D011480:Protease Inhibitors; C014195:Streptomyces pepsin inhibitor; D000976:Antipain; D010664:Phenylmethylsulfonyl Fluoride; C031375:pepstatin
Vliianie ingibitorov proteinaz na uroven' degradatsii i nezaplanirovannogo sinteza DNK v UF- i gamma-obluchennykh kletkakh astsitnoĭ kartsinomy mysheĭ.