Correction of the abnormal ratio of OKT4+ to OKT8+ peripheral blood lymphocytes in patients suffering from juvenile arthritis (JCA) by the extract from calf thymuses.
Children suffering from JCA showed an elevated percentage of OKT4+ T lymphocytes and an increased ratio of OKT4+ to OKT8+ lymphocytes. Several children showing a significant aggravation of the disease, were selected for a 3-week treatment with TFX. In 7 out of 10 patients a pronounced clinical and laboratory improvement was registered, accompanied by a normalization of the OKT4+ to OKT8+ lymphocyte ratio.
Podwysocka
M
M
Pediatric Department, Provincial Hospital, Wrocław.
Wieczorek
Z
Z
Zimecki
M
M
Prusek
W
W
Wieczorek
E
E
Spiegel
K
K
D000293:Adolescent; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D001171:Arthritis, Juvenile / Q000188:drug therapy* / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology*; D002457:Cell Extracts / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000378:metabolism*; D014020:Tissue Extracts / Q000627:therapeutic use*
D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D002457:Cell Extracts; D014020:Tissue Extracts