title: Experimental studies on effects of long-term ethanol administration on meprobamate elimination from blood.
abstract: When rabbits were administered different amounts of ethanol during 25 and 50 days, the elimination of meprobamate from blood was not accelerated at daily ethanol dose of 0.4g/kg. The elimination was accelerated a little at daily ethanol dose of 0.8g/kg and markedly accelerated at the dose of 1.6g/kg. However, it was not accelerated furthermore at the dose of 2.4g/kg. Thus, accelerative effect of long-term ethanol administration on meprobamate metabolism may be greatly related to ethanol dosage and it is considered that the accelerative effects reach maximum at blood ethanol concentrations more than 1mg/ml. Also, elimination of meprobamate from brain in rats was fairly accelerated by long-term ethanol administration at the daily dose of 0.4g.
authors.forename: F
authors.initials: F
authors.lastname: Moriya
authors.forename: R
authors.initials: R
authors.lastname: Nanikawa
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage*; D008297:Male; D008620:Meprobamate / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits; D051381:Rats; D013997:Time Factors
chemical_list: D000431:Ethanol; D008620:Meprobamate