Carboxymethyl- and carboxy-derivatives of 7H- and 5H-1,2,4-triazolo [3,4-b][1,3,4] thiadiazine: synthesis and biological evaluation.
Some carboxymethyl- and carboxy-derivatives of 7H- and 5H-1,2,4-triazolo [3,4-b][1,3,4] thiadiazine were prepared. Their structure are discussed on the basis of IR, NMR and mass spectra. The synthesized compounds were subjected to a preliminary pharmacological screening for antiinflammatory-analgesic activity and to microbiological test on various species of mycetes and bacteria.
Mazzone
G
G
Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania.
Bonina
F
F
Pignatello
R
R
Panico
A M
AM
Caruso
A
A
Leone
M G
MG
Amico-Roxas
M
M
Blandino
G
G
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D008826:Microbial Sensitivity Tests; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000503:physiopathology; D013829:Thiadiazines / Q000138:chemical synthesis* / Q000494:pharmacology; D013843:Thiazines / Q000138:chemical synthesis*; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000700:Analgesics; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002264:Carboxylic Acids; D013829:Thiadiazines; D013843:Thiazines; D014230:Triazoles