[Clinical and hematological analysis of acute granulocytopenia].
Retrospective analysis of 13 patients treated for the acute granulocytopenia at the Institute of Haematology for the last 10 years was carried out. Drugs were the most common causative factor. Comparing the results of the similar analysis several years ago in which the significant role was played by chloramphenicol, non-steroidal anti-inflammatory agents were the main cause. Infective complications were seen in all analysed patients. Broad spectrum antibiotics were used in all patients. Glycocorticosteroids were given to 9 patients while leucocytic concentrates to 7 patients. Remission was achieved in 12 patients, one female patient with the history of exposition to plant protection agents and increased levels of chlorinated aromatic hydrocarbons--died. Intensive antibacterial therapy significantly lowered mortality of the analysed patients in comparison with the similar group analysed earlier. Recurrence of granulocytopenia was seen in 5 patients following the contact with causative agent. Recurrencies were finished with remission.
Deptała
A
A
Niemierko
E
E
Sablińska
K
K
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D002701:Chloramphenicol / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008875:Middle Aged
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002701:Chloramphenicol
Analiza kliniczna i hematologiczna ostrych granulocytopenii.