title: [Biotransformation of pyridazines. 1. Pyridazine and 3-methylpyridazine].
abstract: Pyridazin (1) and 3-methylpyridazine (6) undergo oxidative biotransformation in an unexpected high degree. Beside the unchanged compounds, after administration of 1 two isomeric monohydroxylated products (2, 3), 4,5-dihydrodihydroxypyridazine (4) and 4,5-dihydroxypyridazine (5) and after administration of 6 one ringhydroxylated 6-derivative (7), 3-hydroxymethylpyridazine (8), one ringhydroxylated 3-hydroxymethylpyridazine derivative (9) and 4,5-dihydroxy-3-methylpyridazine (10) were suggested as urinary metabolites in rats. 2 and 7 are the main metabolites of 1 and 6, respectively.
authors.affiliation: Sektion Chemie, Wissenschaftsbereich Pharmazie, Humboldt-Universität zu Berlin.
authors.forename: H H
authors.initials: HH
authors.lastname: Borchert
authors.forename: S
authors.initials: S
authors.lastname: Pfeifer
authors.forename: B
authors.initials: B
authors.lastname: Helbig
authors.forename: P
authors.initials: P
authors.lastname: Franke
authors.forename: G
authors.initials: G
authors.lastname: Heinisch
mesh_terms: D000818:Animals; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D008297:Male; D011724:Pyridazines / Q000378:metabolism* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011724:Pyridazines; C062483:3-methylpyridazine; C062482:pyridazine
vernacular_title: Biotransformation von Pyridazinen. Teil 1: Pyridazin und 3-Methylpyridazin.