[Effectiveness of radiotherapy of patients with cancer of the cervix uteri at the Central Research Roentgeno-Radiological Institute of the USSR Ministry of Health].
The results of radiation treatment for cervical cancer obtained at the Institute Clinic are discussed. Modification-free irradiation was given to 205 patients. Five-year survival was 94 +/- 4% in stage I, 83 +/- 3%--II and 38 +/- 9% in stage III tumor. Dimethylsulfoxide was administered to prevent radiation injury in 48 patients. Radiation injury to the bladder and rectum was observed in 4.9% of cases for each site whereas in controls the indexes were 6.3 and 13.6%, respectively. In 84 patients, dimethylsulfoxide was used in combination with metronidazole to potentiate radiation damage to tumor. This was followed by a significantly more rapid regression of neoplasms. Two-year survival rate in cases receiving topical treatment with both drugs was 75% while in controls--43%.
Kholin
V V
VV
Zharinov
G M
GM
D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use; D011832:Radiation Injuries / Q000517:prevention & control; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000532:radiotherapy*
D008795:Metronidazole; D004121:Dimethyl Sulfoxide
Effektivnost' luchevoĭ terapii bol'nykh rakom sheĭki matki v TsNIRRI Minzdrava SSR.