New method for the preparation of cyanoacrylic nanoparticles with improved colloidal properties.
The purpose of this study was to prepare nanoparticles with a size significantly smaller than 0.1 micron. It was shown that when sulphur dioxide was dissolved in the cyanoacrylic monomer at a high concentration, subsequent anionic polymerization in an aqueous phase produced particles as small as 10 nm. Moreover, the obtained particles displayed an important negative charge which improve their stability against aggregation. Finally, nanoparticles were successfully prepared in double-distilled water, thereby avoiding the use of dextran which can induce anaphylactoid reactions.
Lenaerts
V
V
Faculté de pharmacie, Université de Montréal, Québec, Canada.
Raymond
P
P
Juhasz
J
J
Simard
M A
MA
Jolicoeur
C
C
D002626:Chemistry, Pharmaceutical; D003102:Colloids / Q000032:analysis*; D003487:Cyanoacrylates / Q000138:chemical synthesis*; D004339:Drug Compounding; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D010316:Particle Size; D013458:Sulfur Dioxide / Q000032:analysis
D003102:Colloids; D003487:Cyanoacrylates; D013458:Sulfur Dioxide