A possible harmful late effect of methylprednisolone therapy on a time cluster of optic neuritis.
Clinical records of all patients (n = 26) suffering from optic neuritis during the last 16 years re-evaluated in relation to treatment. The patients were treated in 3 ways: with prednisone; with "pulse" megadoses of methylprednisolone; and untreated. A possibly frightening conversion to multiple sclerosis was seen in the group of patients with methylprednisolone, compared with the other 2 groups.
Herishanu
Y O
YO
Department of Neurology, Soroka Medical Center, Beer Sheva, Israel.
Badarna
S
S
Sarov
B
B
Abarbanel
J M
JM
Segal
S
S
Bearman
J E
JE
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000139:chemically induced*; D009902:Optic Neuritis / Q000188:drug therapy*
D008775:Methylprednisolone