title: [Use of urinary furazolidone determination in calves in laboratory diagnosis].
abstract: We examined 41 samples of calf urine in order to determine the urinary furazolidone excretion. 26 calves were administered furazolidone in the form of Terapeutan T in a therapeutic dose of 5 kg per os individually, which represents approx. 3 mg of furazolidone per kg body weight per day over 5 days. 11 calves were administered with twice the therapeutic dose, i.e. 6 mg furazolidone per kg live body weight over the same 5 days. A triple strength dose was administered to two calves on the 2nd and 3rd days and after administration we observed the furazolidone excretion in urine. The dynamics of furazolidone excretion in urine of one calf we determined even after the fivefold dose in comparison with the therapeutic dose, administered in the course of 2 days after application of the double dose, which was administered over 4 days. During administration of 3 mg and 6 mg furazolidone respectively per kg of live weight per kg furazolidone was excreted in urine minimally and only rarely (7.6%). During administration of higher doses furazolidone was found in the urine of all individuals. The highest urinary concentration of furazolidone in calves was determined after administration of the fivefold dose in comparison with the therapeutic dose, i.e. 15 mg furazolidone per kg live weight in the 4th hour after urine collection (23.0 mg furazolidone per liter urine). When this dose was administered over 2 days, it did not effect any clinical symptoms of disease. It has proved to be well founded to determine the furazolidone level in calf urine in laboratory diagnostics. The examination contributes to the estimation of the furazolidone dose, administered to calves. Urinary furazolidone concentrations greater than 1.0 mg.l-1 provide warning signals of overdosage with this chemotherapeutic. For urine furazolidone determination we utilized the photometric method, described by Herret and Buzard (1960).
authors.forename: E
authors.initials: E
authors.lastname: Szabóová
authors.forename: J
authors.initials: J
authors.lastname: Dányi
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000652:urine; D005664:Furazolidone / Q000506:poisoning / Q000652:urine*
chemical_list: D005664:Furazolidone
vernacular_title: Vyuzitie stanovenia furazolidonu v moci teliat pri laboratórnej diagnostike.