Testicular damage induced by megadoses of pyridoxine.
Pyridoxine hydrochloride, 125 mg/kg, 250 mg/kg, 500 mg/kg or 1,000 mg/kg, daily, was intraperitoneally injected into Wistar male rats and its effects on weights and mature spermatid or sperm counts in the testis and the epididymis were investigated. After six weeks administration, weights of the testis and the epididymis in the 500 mg/kg and 1,000 mg/kg groups dramatically decreased and weights of the epididymis in the 125 mg/kg and 250 mg/kg groups also decreased significantly. Mature spermatid counts in the testis and sperm counts in the epididymis decreased in the 500 mg/kg and 1,000 mg/kg groups, and sperm counts in the tail plus body of the epididymis also decreased in the 250 mg/kg group. From these results, it was elucidated that megadoses of pyridoxine induced testicular damage in rats.
Mori
K
K
Department of Environmental Toxicology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Kaido
M
M
Fujishiro
K
K
Inoue
N
N
D000818:Animals; D001284:Atrophy; D004822:Epididymis / Q000187:drug effects / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011736:Pyridoxine / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013076:Sperm Count / Q000187:drug effects; D013079:Sperm Maturation / Q000187:drug effects; D013087:Spermatids / Q000187:drug effects / Q000254:growth & development; D013091:Spermatogenesis / Q000187:drug effects; D013733:Testicular Diseases / Q000139:chemically induced* / Q000503:physiopathology; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D011736:Pyridoxine