title: Regional cerebral blood flow by SPECT imaging in Sturge-Weber disease: an aid for diagnosis.
abstract: Regional cerebral blood flow (rCBF) was studied using SPECT (single photon emission computed tomography) with 133-Xenon in 13 patients with confirmed Sturge-Weber disease, aged 9 months to 18 years. CT scan, performed at the same time, showed evident cerebral angioma in 10 but not in three. A marked hypoperfused area was found in all patients, ranging from -32% to -72% and of the same location as the CT signs. The hypoperfusion seems to result from post ictal phenomenon as well as from chronic ischaemia. SPECT imaging is therefore a sensitive method for visualising intracranial angioma in Sturge-Weber disease and it provides an aid for diagnosis when a CT scan is not reliable.
authors.affiliation: Clinique de Pédiatrie et de Puériculture, Hôpital Saint Vincent de Paul, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Chiron
authors.forename: C
authors.initials: C
authors.lastname: Raynaud
authors.forename: N
authors.initials: N
authors.lastname: Tzourio
authors.forename: C
authors.initials: C
authors.lastname: Diebler
authors.forename: O
authors.initials: O
authors.lastname: Dulac
authors.forename: M
authors.initials: M
authors.lastname: Zilbovicius
authors.forename: A
authors.initials: A
authors.lastname: Syrota
mesh_terms: D000293:Adolescent; D000798:Angiomatosis / Q000175:diagnosis*; D002545:Brain Ischemia / Q000209:etiology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004827:Epilepsy / Q000150:complications / Q000503:physiopathology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D013341:Sturge-Weber Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed