[Compensatory-adaptive modifications of the C-cell apparatus of the thyroid in normal rats of various ages and in partial sympathectomy].
Population of the thyroid C-cells, normal and at sympathectomy has been analyzed in 75 white male rats at the age of 1, 3 and 6 months by means of electron microscopical, morphometrical and radioimmunological methods. Partial sympathectomy has been performed using subcutaneous injection of guanethidine (15 mg/kg of body mass) during 14 days after birth. During the period from 1 up to 6 months of life in intact rats a decrease in C-cells functional activity is observed. Under conditions of sympathectomy in 30-day-old animals decreasing extrusion processes of the secretory material are observed. During successive periods of life (3 and 6 months) mechanisms of paracrinic evacuation of hormonal products enhance considerably, nuclear volume of the cells and number of C-cells in the field of vision increase. Their hyperplastic alterations in the sympathectomized thyroid gland are more pronounced in 3-month-old animals.
Riashchikov
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D000222:Adaptation, Physiological / Q000502:physiology*; D000375:Aging / Q000502:physiology*; D000818:Animals; D002116:Calcitonin / Q000097:blood; D002452:Cell Count; D006145:Guanethidine; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000502:physiology*; D013961:Thyroid Gland / Q000166:cytology* / Q000294:innervation / Q000502:physiology
D002116:Calcitonin; D006145:Guanethidine
Nekotorye aspekty kompensatorno-prisposobitel'nykh modifikatsiĭ C-kletochnogo apparata shchitovidnoĭ zhelezy krys raznogo vozrasta v norme i pri chastichnoĭ desimpatizatsii.