Nuclease hypersensitivity of the rat cytochrome P450IA1 gene.
The bovine pancreatic deoxyribonuclease I (DNAase I) hypersensitivity of the rat cytochrome P450IA1 gene was investigated. A nuclease-hypersensitive region was observed at approximately 3.2 to 5.1 kilobase pairs upstream of exon 1 in adult and fetal rat liver. This region did not necessarily correlate with gene expression following 3-methylcholanthrene induction, although it may determine the potential for inducibility of this gene.
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Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, 68105.
Bresnick
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D000818:Animals; D015139:Blotting, Southern; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D003850:Deoxyribonuclease I / Q000494:pharmacology*; D005260:Female; D005333:Fetus; D015870:Gene Expression; D005796:Genes / Q000187:drug effects*; D015698:Genomic Library; D008099:Liver / Q000201:enzymology; D008297:Male; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D003577:Cytochrome P-450 Enzyme System; D003850:Deoxyribonuclease I