title: Effect of retinyl acetate on nuclear proteins in rabbit liver.
abstract: 1. Retinyl acetate injected intraperitoneally to adult rabbits fed on standard diet caused detectable changes in the polyacrylamide gel patterns of liver nucleoplasmic and 0.35 M NaCl-soluble chromatin proteins. 2. Both histones and non-histone proteins soluble in 5 M urea were not affected in vitamin A-treated animals. 3. It seems that variations in liver nuclear proteins from retinyl acetate-administered rabbits may reflect retinol-dependent alterations in structure and function of their chromatins.
authors.affiliation: Department of Genetics, Educational University of Kielce, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Pałyga
authors.forename: K
authors.initials: K
authors.lastname: Grochała
authors.forename: A
authors.initials: A
authors.lastname: Kowalski
authors.forename: M
authors.initials: M
authors.lastname: Sylwestrzak
authors.forename: J
authors.initials: J
authors.lastname: Rafay
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D004224:Diterpenes; D004591:Electrophoresis, Polyacrylamide Gel; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009687:Nuclear Proteins / Q000096:biosynthesis*; D011817:Rabbits; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D002843:Chromatin; D004224:Diterpenes; D009687:Nuclear Proteins; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate