Effect of magnesium lithospermate B on urinary excretion of arachidonate metabolites in rats with renal failure.
The effect of magnesium lithospermate B isolated from Salviae miltiorrhizae Radix on excretion of urinary arachidonate metabolites was examined in both normal rats and those given adenine. Urinary excretion of prostaglandin E2 (PGE2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) decreased while urinary thromboxane B2 (TXB2) excretion increased markedly with the progression of renal failure. Rats administered magnesium lithospermate B showed an increase of urinary PGE2 excretion at the 6th and 12th days. Excretion of 6-keto-PGF1 alpha also showed a significant increase on the 6th and 12th days in rats with renal failure induced by the administration of adenine. However, these effects were lower than the corresponding values in normal rats. In addition, urinary PGE2 and 6-keto-PGF1 alpha excretions showed no appreciable difference in rats that exhibited progressive renal failure with continuation of the adenine administration period, as shown on the 18th and 24th days. There were no significant changes in TXB2 excretion between the control and magnesium lithospermate B-treated groups throughout the experimental period.
Yokozawa
T
T
Chung
H Y
HY
Lee
T W
TW
Oura
H
H
Tanaka
T
T
Nonaka
G
G
Nishioka
I
I
D000818:Animals; D001095:Arachidonic Acids / Q000652:urine*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007676:Kidney Failure, Chronic / Q000652:urine*; D008297:Male; D011453:Prostaglandins / Q000652:urine*; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D004365:Drugs, Chinese Herbal; D011453:Prostaglandins; C061091:lithospermate B