Brain neuron gene expression in the organization of innate and acquired behaviors.
In a series of experiments using rats and rabbits, it was determined that regulatory peptides played a role in the mechanisms of learned behavior. Learning a new habit as a conditional avoidance response was accompanied by a considerable increase in brain DNA synthesis, which in turn could result in RNA and protein synthesis activation. The results suggest the following interdependent molecular phenomena: 1) DNA synthesis activation; 2) genome expression of a certain type of oligopeptides; 3) regulation of genome expression of proteins by chromatin nonhistone proteins; 4) regulation of gene expression mechanisms by brain regulatory peptides.
Sudakov
K V
KV
P.K. Anokhin Institute of Normal Physiology, USSR Academy of Medical Sciences, Moscow.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics; D003214:Conditioning, Classical / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology*; D006372:Helix, Snails; D007323:Instinct; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010455:Peptides / Q000235:genetics; D011817:Rabbits; D051381:Rats
D002868:Chromosomal Proteins, Non-Histone; D009419:Nerve Tissue Proteins; D010455:Peptides