Membrane fluidity changes in polymorphonuclear leukocytes and erythrocytes in psoriasis.
We studied membrane fluidity in living polymorphonuclear leukocytes and in erythrocytes of 8 psoriatic patients, using fluorescence polarization of 1-(4-trimethylaminophenyl)-6-phenyl-1,3,5-hexatriene. In erythrocyte membranes of psoriatic patients we observed a decrease of fluidity, these changes were not associated to relevant modifications of the cholesterol to phospholipid molar ratio. Moreover, we observed a decrease in polymorphonuclear leukocytes membrane fluidity. Our results indicate changes in membrane fluidity involving membranes different from the epidermal cells and suggest the hypothesis of a defect in membrane-cytoskeleton interactions in psoriasis.
Offidani
A M
AM
Institute of Dermatology, School of Medicine, University of Ancona, Italy.
Simonetti
O
O
Ferretti
G
G
Curatola
G
G
Bossi
G
G
D000293:Adolescent; D000328:Adult; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005454:Fluorescence Polarization / Q000379:methods; D006801:Humans; D008297:Male; D008560:Membrane Fluidity; D009504:Neutrophils / Q000378:metabolism*