title: [Effects of 8 antitumor drugs against the growth of human lung adenocarcinoma (LAX-83) transplanted under the kidney capsule of nude mice].
abstract: Nude mice, inoculated with LAX 83 in bilateral subrenal capsules, were used in experimental therapy with 8 antitumor drugs. Treatment was initiated 2 d after tumor inoculation. All the drugs were ip to the nude mice daily for 7 d. At the daily doses VCR 0.4, MMC 2, CCNU 16, cis-DDP 2, AdM 2.5, 5-Fu 30, CTX 40 and MTX 2-6 mg/kg, the inhibition of the tumor growth were 100, 95.8, 91.3, 79.2, 65.2, 60.7, 62.3 and 0%, respectively. The results indicated that the effects of the drugs on nude mice inoculated with LAX-83 in subrenal capsule not only exhibited a good correlation to those in sc, but also shortened the period of experiment from 22 to 11 d. Furthermore, when LAX-83 was inoculated into the subrenal capsule of Swiss +/+ mice, the tumor tissues degenerated and disintegrated 2 d after the inoculation and replaced by inflammatory granuloma tissues 6 d later.
authors.forename: S Y
authors.initials: SY
authors.lastname: Zhang
authors.forename: Y H
authors.initials: YH
authors.lastname: Shu
authors.forename: J L
authors.initials: JL
authors.lastname: Zhang
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Lin
authors.forename: C W
authors.initials: CW
authors.lastname: Xu
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D013370:Subrenal Capsule Assay
chemical_list: D000970:Antineoplastic Agents