title: [Unusual complications of anticoagulation therapy].
abstract: In the introduction to the work the authors deal with the problems of the prevention of flebotromboses in patients operated on in the area of proximal part of the femur. They analyze ways of physical and pharmacological prevention and point out the potential undesirable effects and unusual complications in the treatment by means of Heparin and Kumarin derivatives--and namely the toxoallergic reaction to Heparin and the necrosis of skin and subcutis in case of the application of Kumarin drugs. In Kumarin necrosis the etiology of the which has not been, unequivocally elucidated, yet, they present views on the causes of its origin and describe the course of the Kumarin necrosis. They summarize predispositional factors which increase the risk of its occurrence and present their own observations of two cases. In the discussion they deal with the views on the etiology of the origin of this complication. In the conclusion they recommend the treatment in compliance with the latest findings.
authors.forename: V
authors.initials: V
authors.lastname: Vyskocil
authors.forename: J
authors.initials: J
authors.lastname: Pelnár
authors.forename: J
authors.initials: J
authors.lastname: Steiningerová
mesh_terms: D000368:Aged; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D009336:Necrosis; D011183:Postoperative Complications / Q000517:prevention & control; D012871:Skin Diseases / Q000139:chemically induced*; D013927:Thrombosis / Q000517:prevention & control
chemical_list: D006493:Heparin
vernacular_title: Neobvyklé komplikace antikoagulacní lécby.