Correlation of Cu(PTSM) localization with regional blood flow in the heart and kidney.
In a dog model of myocardial ischemia, i.v. injection of [67Cu]Cu(PTSM) leads to an excellent linear correlation for both the heart and kidney between regional tissue radiocopper concentration and regional blood flow measured by radioactive micropheres. The 62Cu-labeled complex may serve as a generator-produced position-emitting perfusion tracer for these organs.
Barnhart
A J
AJ
School of Pharmacy, Purdue University, West Lafayette, IN 47907.
Voorhees
W D
WD
Green
M A
MA
D000818:Animals; D003301:Copper Radioisotopes; D003326:Coronary Circulation; D004285:Dogs; D006321:Heart / Q000000981:diagnostic imaging*; D007668:Kidney / Q000000981:diagnostic imaging*; D008863:Microspheres; D009942:Organometallic Compounds; D011877:Radionuclide Imaging; D012079:Renal Circulation; D013326:Strontium Radioisotopes; D013882:Thiosemicarbazones
D003301:Copper Radioisotopes; D009942:Organometallic Compounds; D013326:Strontium Radioisotopes; D013882:Thiosemicarbazones; C052629:copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex