A simplified method for calculating complex metabolic sensitivities by using matrix partitioning.
The matrix method for calculating the overall sensitivities (including control coefficients) of a metabolic system, described by Crabtree & Newsholme [Biochem. J. 247, 113-129 (1987)], is simplified by a preliminary partitioning of the initial matrix equation. This reduces the size of the matrix to be inverted and thereby removes a major drawback with the original method. The resulting procedure is simpler and more systematic than the alternative methods currently available, especially when the system is extensively branched.
Crabtree
B
B
Rowett Research Institute, Aberdeen, Scotland, U.K.
Collins
G
G
Franklin
M I
MI
D008433:Mathematics; D008660:Metabolism