Serum IgA deficiency induced by prolonged phenytoin treatment.
In a longitudinal study we have evaluated several immunological parameters in thirty three epileptic children and adolescents 4 to 14 years old treated with phenytoin, and matched normal controls. The patients had significantly lower levels than normal controls of IgA (153 +/- 89 vs 236 +/- 128 mg/dL p less than 0.001) and IgM (155 +/- 58 vs 217 +/- 105 mg/dL p less than 0.01). The decrease in serum IgA levels correlated with the length of treatment (r = 0.44, p less than 0.03). Eight of the patients had IgA deficiency. In 7 of these children, T lymphocytes subpopulations were determined. The results did not differ significantly from the matched controls.
Talesnik
E
E
Rivero
S J
SJ
González
B
B
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004406:Dysgammaglobulinemia / Q000139:chemically induced*; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D017098:IgA Deficiency; D007958:Leukocyte Count; D008137:Longitudinal Studies; D008214:Lymphocytes; D008297:Male; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
D010672:Phenytoin