Hypocrellin-A sensitized photooxidation of bilirubin.
Hypocrellin A (HA) extracted from Hypocrellia bambusae (b.et Br.) sace, a derivative of 3,10-dihydroxy-4,9-perylenequinone, is a highly effective photosensitizer. Kinetic studies of the HA-sensitized photooxidation of bilirubin IX alpha (BR) in different solvents in the presence of various active oxygen quenchers indicate that in aprotic solvents the photooxidation goes via a Type II (1O2) mechanism, whereas in alkaline protic solvents Type I (electron transfer from an excited state of HA to the ground state of oxygen or the BR substrate). Type II and probably free radical reactions may occur simultaneously.
Ma
J S
JS
Yan
F
F
Wang
C Q
CQ
An
J Y
JY
D001663:Bilirubin / Q000528:radiation effects*; D008027:Light; D010084:Oxidation-Reduction; D010569:Perylene / Q000031:analogs & derivatives*; D019800:Phenol; D011809:Quinones; D011838:Radiation-Sensitizing Agents; D013053:Spectrophotometry
D011809:Quinones; D011838:Radiation-Sensitizing Agents; D019800:Phenol; D010569:Perylene; C028529:photobilirubin; D001663:Bilirubin; C048388:hypocrellin A