Attempts with lipanthyl to improve lipid metabolism during the adaptation period of women taking oral contraceptives.
In the course of a 6-month comparative prospective clinical trial the parameters of fat metabolism in women taking first oral contraceptives of different hormone balances and contents were examined. It has been observed that the different tablets increase within the physiological limits the levels of total cholesterol and triglyceride as well as LDL-cholesterol and--except for the biphasic tablet--they decrease HDL fraction. By administering minimum doses of fenofibrate the increase and changes in fat metabolism may be prevented and the eventual unwanted effects of the adaptation period moderated. The clinical usefulness of the method and some open questions of this therapy have been discussed.
Pilishegyi
J
J
D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D011345:Fenofibrate / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D050356:Lipid Metabolism; D011422:Propionates / Q000627:therapeutic use*; D011446:Prospective Studies; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003276:Contraceptives, Oral; D011422:Propionates; D014280:Triglycerides; D002784:Cholesterol; D011345:Fenofibrate