title: Pulmonary gas exchange during graded exercise in normal, sedentary, non-smoking subjects.
abstract: There is some discordance in the literature on the evolution of the alveolo-arterial oxygen tension difference (A-a)DO2 from rest (R) to graded exercise (E) in healthy subjects. For some authors and not for others (A-a)DO2 increased during exercise. In order to solve this problem we have examined 9 healthy, non-smoking sedentary students (5 males). In every subject PaO2 increased from rest to the highest level of exercise. (A-a)DO2 significantly increased from R and E1 to E2 and from E3 to E4. (A-a)DO2 at rest was 7.5 +/- 4.1 torr; at E1: 7.0 +/- 4.3 torr; at E2: 11.5 +/- 4.2 torr; at E3: 12.5 +/- 3.9 torr; and at E4: 16.5 +/- 4.3 torr. The oxyhemoglobin dissociation curve (ODC) was significantly shifted to the right from 53 to 92% saturation. This shift favours the liberation of O2 from hemoglobin to the tissues but cannot explain the evolution of (A-a)DO2. We believe that the increase in (A-a)DO2 is due to an increased maldistribution of the ventilation-perfusion ratio.
authors.affiliation: Department of Internal Medicine, Universitaires Saint-Luc, Brussels, Belgium.
authors.forename: T
authors.initials: T
authors.lastname: Clerbaux
authors.forename: W
authors.initials: W
authors.lastname: Nullens
authors.forename: C
authors.initials: C
authors.lastname: Veriter
authors.forename: A
authors.initials: A
authors.lastname: Frans
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D010108:Oxyhemoglobins / Q000032:analysis; D010313:Partial Pressure; D005082:Physical Exertion / Q000502:physiology; D011659:Pulmonary Gas Exchange; D012016:Reference Values
chemical_list: D010108:Oxyhemoglobins