title: [The morphogenesis of the structural changes of the exocrine pancreas after ligation of the excretory duct].
abstract: The changes in the exocrine pancreas were investigated after ligature of the excretory duct in 51 Wistar rats. A qualitative microdetermination of the epithelial cells was carried out in the originated ductulus-like structures.
  
  
  CONCLUSIONS
  The acinic epithelial cells grow atrophically first of all and become necrotic in the end. A dedifferentiated acinic cellular atrophy with metamorphosis to a ductulus-like cell type could not be observed. Proliferative and preproliferative events occur in the duct epithelial cells. Cystic ductulus-like structures originated from this. These fill out the former acinic areas by immature, few differentiated, pluripotent epithelial cells that look similar to embryonal pancreatic cells.
authors.affiliation: Klinik für Chirurgie, Wilhelm-Píeck-Universität und dem Bezirkskrankenhaus, Rostock.
authors.forename: R
authors.initials: R
authors.lastname: Rohrbeck
authors.forename: C M
authors.initials: CM
authors.lastname: Rohrbeck
authors.forename: H P
authors.initials: HP
authors.lastname: Putzke
authors.forename: L
authors.initials: L
authors.lastname: Jonas
authors.forename: R
authors.initials: R
authors.lastname: Reding
mesh_terms: D000818:Animals; D001284:Atrophy; D008026:Ligation; D008297:Male; D009336:Necrosis; D010179:Pancreas / Q000473:pathology*; D010183:Pancreatic Ducts / Q000601:surgery*; D051381:Rats; D011919:Rats, Inbred Strains
vernacular_title: Zur Morphogenese des Strukturwandels des exokrinen Pankreas nach Ausführungsgangligatur.