Effects of acetylcholinesterase specific inhibitors on the development of chick embryos.
The effects of specific inhibitors of cholinesterases on chick development were studied. Inhibitors were injected into the eggs, at final concentration ranging between 1 mM and 10 nM. Their effects were depending on inhibitor concentration, and detectable at stages as more advanced as more diluted were the inhibitors. The strongest teratogenic effects on gastrulation, neurulation and morphogenesis were caused by BW 284c51, specific inhibitor of acetylcholinesterase. Its effects were compared to those of ion channels blockers. The inhibitors action seems to be correlated to an altered cholinergic system and to consequently altered intercellular communications.
Parodi
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Falugi
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D000818:Animals; D002093:Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide / Q000494:pharmacology; D002038:Bungarotoxins / Q000494:pharmacology; D002642:Chick Embryo / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003472:Curare / Q000494:pharmacology; D010830:Physostigmine / Q000494:pharmacology; D013770:Tetraisopropylpyrophosphamide / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology
D002038:Bungarotoxins; D002800:Cholinesterase Inhibitors; D002093:Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; D013779:Tetrodotoxin; D013770:Tetraisopropylpyrophosphamide; D003472:Curare; D010830:Physostigmine