Cellular immune response to Listeria in genetically resistant and susceptible mouse strains.
Relatively Listeria-resistant C57B1/6 mice and more susceptible to the infection DBA/2 mice were immunized with Listeria-antigen (LA). Immunized DBA/2 mice developed weaker delayed hypersensitivity to LA and still eliminated listeriae less effectively than identically immunized C57B1/6 mice. An accessory function of LA-pulsed macrophages of normal C57B1/6 mice was only slightly enhanced as compared with LA-pulsed macrophages of DBA/2 mice. It is suggested that some suppressor lymphocytes, IgM+ and/or FcR+, could be responsible for the enhanced susceptibility of DBA/2 mice to listeriosis.
Rudnicka
W
W
Department of Immunology, University of Lódź, Poland.
Długońska
H
H
Chmiela
M
M
Paziak-Domańska
B
B
Wiewióra
A
A
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D002455:Cell Division; D004198:Disease Susceptibility; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007114:Immunization; D008087:Listeria / Q000276:immunology*; D008088:Listeriosis / Q000276:immunology*; D008264:Macrophages / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013154:Spleen / Q000166:cytology / Q000382:microbiology
D000942:Antigens, Bacterial