title: Association of anti-DNA and anticardiolipin antibodies in systemic lupus erythematosus.
abstract: Recent studies have shown that anti-DNA and anticardiolipin antibodies in patients with SLE may cross-react. Using an ELISA for determination of these antibodies, a strong association between IgG anti-denatured DNA and IgG anticardiolipin antibodies was found. Eight sera samples with the highest levels of both antibodies were selected to determine the possibility of a cross-reaction. The levels of anticardiolipin were not affected by denatured DNA in concentrations adequate to inhibit the anti-DNA binding. These data did not confirm previous studies using monoclonal antibodies showing cross reactivity between the two groups of antibodies. Nevertheless, a population of antibodies that may cross-reacts, in some special cases, cannot be ruled out.
authors.forename: R M
authors.initials: RM
authors.lastname: de Oliveira
authors.forename: C
authors.initials: C
authors.lastname: Bueno
authors.forename: V S
authors.initials: VS
authors.lastname: Viana
authors.forename: N H
authors.initials: NH
authors.lastname: Yoshinari
authors.forename: W
authors.initials: W
authors.lastname: Cossermelli
authors.forename: M B
authors.initials: MB
authors.lastname: Santiago
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis / Q000276:immunology*; D002308:Cardiolipins / Q000276:immunology*; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D002308:Cardiolipins