[Phospholipid-glycerides, cross-resistance of erythrocytes, malonic dialdehyde level and alpha-tocopherol levels in the plasma and erythrocytes of rats with alloxan diabetes before and after combined antioxidant therapy].
Quantitative and qualitative alterations in content of phospholipids were studied in erythrocytes of rats with alloxan diabetes: rate of lipid peroxidation and content of L-tocopherol were estimated in blood plasma before and after the antioxidant therapy. Patterns of lipid metabolism were normalized after the course of treatment involving simultaneous administration of L-tocopherol and ascorbic acid within 10-15 days. The antioxidants used decreased the rate of lipid peroxidation in erythrocyte membranes and stimulated biosynthesis of phospholipids de novo. Role of antioxidants in phospholipid metabolism is discussed.
Karagezian
K G
KG
Gevorkian
D M
DM
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000378:metabolism*; D005994:Glycerophosphates / Q000097:blood*; D008297:Male; D008314:Malonates / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood*; D051381:Rats; D013997:Time Factors; D014810:Vitamin E / Q000097:blood*
D000975:Antioxidants; D005994:Glycerophosphates; D008314:Malonates; D014810:Vitamin E; D008315:Malondialdehyde
Fosfolipidy-glitseridy, perekisnaia rezistentnost' éritrotsitov, uroven' v nikh malonovogo dial'degida i soderzhanie alpha-tokoferola v plazme krovi i éritrotsitakh krys s alloksanovym diabetom do i posle primeneniia kombinirovannoĭ antioksidantoterapii.