Chemical combination of 6-deoxy-6-mycoloylamino-alpha,alpha-trehalose and N-acetyl-6-O-(aminoacyl)muramoyl dipeptide.
6-Deoxy-6-mycoloylamino-alpha,alpha-trehalose, a biologically active derivative of 6,6'-di-O-mycoloyl-alpha,alpha-trehalose (TDM), and N-acetyl-6-O-(aminoacyl)-muramoyl dipeptide (MDP) were joined chemically by a succinic acid unit. The compounds synthesized showed activities that are characteristics of both TDM and MDP.
Ishida
H
H
Department of Applied Bioorganic Chemistry, Gifu University, Japan.
Ogawa
Y
Y
Imai
Y
Y
Kiso
M
M
Hasegawa
A
A
Sakurai
T
T
Azuma
I
I
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000138:chemical synthesis*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D003311:Cord Factors; D006017:Glycolipids; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D008262:Macrophage Activation; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D008546:Melanoma, Experimental; D051379:Mice; D015394:Molecular Structure; D009904:Optical Rotation; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects
C063099:6-deoxy-6-mycoloylamino-alpha,alpha-trehalose; D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D003311:Cord Factors; D006017:Glycolipids; D000119:Acetylmuramyl-Alanyl-Isoglutamine