title: [Multiple carcinoma of the upper aerodigestive tract of metachronic onset].
abstract: One of the most important concepts in the understanding of the biology of squamous cell carcinoma of the head and neck is "multicentric cancer" as proposed by Slaughter et al. in 1953. With prolonged survival as a result of improved cancer therapy, the possibility of a second primary lesion should always be kept in mind during patient follow-up. A late or unusual metastasis in a patient with upper aerodigestive malignancy should be suspected of having a new primary carcinoma. In the last 12 months, we have treated 72 patients with upper aerodigestive malignancy. 5 of them had a history of previous squamous cell carcinoma of head and neck treated 6-13 years before. Probable etiopathogenic factors are discussed.
authors.forename: A
authors.initials: A
authors.lastname: Menoyo
authors.forename: J
authors.initials: J
authors.lastname: Jiménez
authors.forename: B
authors.initials: B
authors.lastname: Bhathal
authors.forename: S
authors.initials: S
authors.lastname: Fernández
authors.forename: J
authors.initials: J
authors.lastname: Poch
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery; D004825:Epiglottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000473:pathology / Q000601:surgery
vernacular_title: Carcinoma múltiple de vías aerodigestivas superiores de aparición metacrónica.