title: [Postoperative lymphotropic antibiotic therapy of urology patients with suppurative-septic complications].
abstract: Antibiotic treatment plays an important role in the prevention of pyoseptic complications of urologic surgery. However, conventional treatment results in irregular distribution of the antibiotic agent through the liquid media of the body, the emergence of resistant bacterial strains and lymphostasis, while higher doses increase toxic effect on the kidneys, aggravating the clinical condition. Treatment efficiency has been shown to be dependent on the effective dose of the drug in the inflammation focus, which is achieved through its endolymphatic administration. These techniques, however, are complicated and time-consuming. These shortcomings are avoided when lymphotropic antibiotic treatment (LAT), based on the combination of mechanical action on venous outflow and regional stimulation of lymphogenic absorption, using lymphostimulating effects of hemodilution and heparin, is administered. Some hemostatic parameters were examined in 49 patients (aged 50.4 +/- 7.4 years) following urologic operations. LAT was used in 28 of those. It is shown to provide a better antibiotic saturation of the lymphatic system, as compared to conventional treatment. LAT prevents postoperative pyoseptic complications, reduces 4 to 6-fold the consumption of antibacterial drugs and alleviates their urinary side-effects. Owing to its simplicity and effectiveness, the method can be recommended for wide-scale clinical application.
authors.forename: S N
authors.initials: SN
authors.lastname: Lynev
authors.forename: S V
authors.initials: SV
authors.lastname: Tumanian
authors.forename: R N
authors.initials: RN
authors.lastname: Samedov
authors.forename: A G
authors.initials: AG
authors.lastname: Akhundov
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007279:Injections, Subcutaneous; D008196:Lymph / Q000187:drug effects*; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods*; D013530:Surgical Wound Infection / Q000097:blood / Q000188:drug therapy*; D014570:Urologic Diseases / Q000097:blood / Q000150:complications / Q000601:surgery*
chemical_list: D000900:Anti-Bacterial Agents; D006493:Heparin
vernacular_title: Posleoperatsionnaia limfotropnaia antibiotikoterapiia u urologicheskikh bol'nykh s gnoĭno-septicheskimi oslozhneniiami.