title: Growth inhibitory effect of diheptyl diselenide on various human cancer cell lines.
abstract: We tested the antiproliferative effects of Diheptyl Diselenide (DHDSe) on several different human cancer cell lines. Cells derived from human cancer (CG5), colon cancer (WIDR), laryngeal cancer (Hep-2), ovarian cancer (OV 166, OV 1225) and IM-9 lymphoblastoid cells were used. In all cell lines DHDSe inhibited cell growth in a dose dependent manner. At the highest concentration tested, an inhibition of cell proliferation ranging from 48% to 75% compared with control cells was observed. Our results show that DHDSe exerts a direct antiproliferative effect on human cancer cells in vitro and suggest that it may represent the parent compound of a new group of anticancer agents.
authors.affiliation: Department of Gynecology, Catholic University, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Scambia
authors.forename: P B
authors.initials: PB
authors.lastname: Panici
authors.forename: F
authors.initials: F
authors.lastname: Battaglia
authors.forename: G
authors.initials: G
authors.lastname: Ferrandina
authors.forename: C
authors.initials: C
authors.lastname: Gaggini
authors.forename: S
authors.initials: S
authors.lastname: Mancuso
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004261:DNA Replication / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006536:Heptanes / Q000494:pharmacology*; D006801:Humans; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D006536:Heptanes; C063339:diheptyldiselenide