title: [Metabolism of an antiepileptic drug halonal in experimental studies].
abstract: A study was made of metabolism of the new antiepileptic drug halonal in guinea-pigs. It was established that on oral administration halonal was not absorbed from the intestinal tract and only its metabolite, phenobarbital, was detectable in blood serum. It is assumed that halonal produces a therapeutic action only thanks to phenobarbital, its pharmacologically active metabolite.
authors.forename: V M
authors.initials: VM
authors.lastname: Okudzhava
authors.forename: B G
authors.initials: BG
authors.lastname: Chankvetadze
authors.forename: M M
authors.initials: MM
authors.lastname: Rogava
authors.forename: M D
authors.initials: MD
authors.lastname: Rukhadze
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001463:Barbiturates / Q000494:pharmacology* / Q000627:therapeutic use; D001682:Biological Availability; D055598:Chemical Phenomena; D002621:Chemistry; D004353:Drug Evaluation, Preclinical; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D006168:Guinea Pigs; D007408:Intestinal Absorption / Q000502:physiology; D010634:Phenobarbital / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D001463:Barbiturates; C062695:halonal; D010634:Phenobarbital
vernacular_title: Metabolizm protivoépilepticheskogo preparata galonala v éksperimente.