The acute pressor response to cadmium in rats.
In rats, acute i.v. administration of CdCl2 (0.5 and 1 mg/kg) produced a depressor response followed by a pressor response, while the acute i.p. administration of CdCl2 (0.5 and 1 mg/kg) produced only a pressor response. Phentolamine (5 mg/kg, i.v.), hexamethonium (10 mg/kg, i.v.), propranolol (2 mg/kg, i.v.) and indomethacin (20 mg/kg, i.p.) as well as bilateral adrenalectomy, acute reserpinization and chemical sympathectomy by guanethidine did not modify the acute pressor response to CdCl2. Verapamil (1 mg and 2 mg/kg, i.v.) and nifedipine (0.25 and 0.5 mg/kg, i.v.) prevented the acute pressor response to CdCl2 administered by either i.v. or i.p. route. Phentolamine (10 micrograms/ml) could not prevent the rise in perfusion pressure of the rat hindquarter due to intra-arterial CdCl2 administration. However, verapamil (50 and 100 micrograms/ml) prevented rise in perfusion pressure. It is concluded that cadmium ion might mimic calcium ion and produce a direct contractile effect on the vascular smooth muscle.
Balaraman
R
R
Pharmacy Department, Faculty of Technology and Engineering, M. S. University, Baroda, Gujarat, India.
Gulati
O D
OD
Rathod
S P
SP
Bhatt
J D
JD
D000315:Adrenalectomy; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002104:Cadmium / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006614:Hindlimb / Q000098:blood supply; D007275:Injections, Intravenous; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology; D013563:Sympathectomy, Chemical
D002121:Calcium Channel Blockers; D006584:Hexamethonium Compounds; D002104:Cadmium; D012110:Reserpine; D011433:Propranolol; D010646:Phentolamine