title: Synthesis of [11C]sodium thiocyanate for in vivo studies of anion kinetics using positron emission tomography (PET).
abstract: Sodium thiocyanate (NaSCN) was labelled with carbon-11 for in vivo studies of anion kinetics using positron emission tomography (PET). The synthesis was complete in 35 min from end of bombardment using [11C]ammonium cyanide as the labelled precursor. [11C]NaSCN was produced by the reaction of [11C]sodium cyanide with elemental sulfur and subsequently separated by semi-preparative high performance liquid chromatography (HPLC). Radiochemical yields (isolated) were of the order of 25%. The specific activity was 18 GBq/mmol and the radiochemical purity better than 99%. A PET study performed in a healthy volunteer showed distribution of [11C]SCN- to areas corresponding to cortical fluid spaces known to be accessible to inorganic ions such as Cl-. An accumulation of the tracer was observed during the 70 min investigation, indicating at least three compartments of distribution.
authors.affiliation: Karolinska Pharmacy, Stockkholm, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Stone-Elander
authors.forename: P
authors.initials: P
authors.lastname: Roland
authors.forename: C
authors.initials: C
authors.lastname: Halldin
authors.forename: M
authors.initials: M
authors.lastname: Hassan
authors.forename: R
authors.initials: R
authors.lastname: Seitz
mesh_terms: D000838:Anions / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D002250:Carbon Radioisotopes; D006801:Humans; D007553:Isotope Labeling / Q000379:methods*; D007700:Kinetics; D013861:Thiocyanates; D014055:Tomography, Emission-Computed
chemical_list: D000838:Anions; D002250:Carbon Radioisotopes; D013861:Thiocyanates; C024553:sodium thiocyanate