[The role of long-chain acyl-CoA in the disturbances of oxidative phosphorylation in the myocardium].
The effect of intramitochondrial acyl-CoA on the respiration of rabbit heart mitochondria in different metabolic states was studied. Acyl-CoA inhibited O2 consumption by 11% in State 4 and by 6% in State 3. However, the effect of acyl-CoA was more pronounced (20%) in the intermediate state of respiration between State 4 and State 3. The data obtained suggest that acyl-CoA can regulate oxidative phosphorylation in heart mitochondria in vivo.
Borutaĭte
V I
VI
Mildazhene
V Iu
VIu
Ivanovene
L I
LI
Kholodenko
B N
BN
Toleĭkis
A I
AI
Prashkiavichius
A K
AK
D000214:Acyl Coenzyme A / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D007700:Kinetics; D008929:Mitochondria, Heart / Q000201:enzymology / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D011817:Rabbits
D000214:Acyl Coenzyme A; D000244:Adenosine Diphosphate; D003402:Creatine Kinase
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