Pefloxacin in the treatment of gram-negative infections in patients with hematologic diseases.
Quinolones are active against gram-negative strains. They are commonly used for selective intestinal decontamination in patients with hematologic malignancies and prolonged neutropenia due to chemotherapy. In our open study we used pefloxacin, a new fluoroquinolone, for the treatment of fifteen documented gram-negative infections in hematologic patients. Thirteen patients were mildly neutropenic, and in nine cases they received oral treatment as non-hospitalized patients. Cure was achieved in fourteen cases, with microbiological eradication of the offending pathogen.
Micozzi
A
A
Martino
P
P
Raccah
R
R
Girmenia
C
C
Gentile
G
G
Santilli
S
S
Monarca
B
B
D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006090:Gram-Negative Bacteria; D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D008297:Male; D015366:Pefloxacin / Q000627:therapeutic use*
D015366:Pefloxacin