title: Time courses of the responses of pyruvate dehydrogenase activities to short-term starvation in diaphragm and selected skeletal muscles of the rat.
abstract: In the fed state, the percentages of the pyruvate dehydrogenase complex (PDH) in the active form (PDHa) in diaphragm and a selection of skeletal muscles (adductor longus, soleus, extensor digitorum longus, tibialis anterior, gastrocnemius) ranged from 8% (soleus) to 38% (gastrocnemius). Major decreases in PDHa activities in all of these muscles were observed after 15 h of starvation, by which time activities were less than 40% of the fed values. In general, the response to starvation was observed more rapidly in muscles of high oxidative capacity. The patterns of changes in skeletal-muscle PDH activities during the fed-to-starved transition are discussed in relation to changes in lipid-fuel supply and oxidation.
authors.affiliation: Department of Biochemistry, London Hospital Medical College, U.K.
authors.forename: M J
authors.initials: MJ
authors.lastname: Holness
authors.forename: Y L
authors.initials: YL
authors.lastname: Liu
authors.forename: M C
authors.initials: MC
authors.lastname: Sugden
mesh_terms: D000818:Animals; D003964:Diaphragm / Q000201:enzymology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007657:Ketone Bodies / Q000097:blood; D009130:Muscle, Smooth / Q000201:enzymology; D009132:Muscles / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology; D009928:Organ Specificity; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000097:blood / Q000201:enzymology*; D013997:Time Factors
chemical_list: D005230:Fatty Acids, Nonesterified; D007657:Ketone Bodies; D011768:Pyruvate Dehydrogenase Complex