The effect of ethanol on arterial blood pressure, central venous pressure and ECG in rabbits treated with the single or multiple dose of amitriptyline or imipramine.
Amitriptyline and imipramine given in the single dose insignificantly depressed the arterial blood pressure but significantly elevated the central venous pressure, prolonged the PQ interval and widened the QRS complex. After a prolonged daily treatment, the subsequent 21st dose of either antidepressant significantly depressed the arterial blood pressure; amitriptyline also depressed the central venous pressure. When given chronically, amitriptyline induced rhythm disturbances and the flattening of T-wave, while imipramine caused the widening of the QRS complex, block of the left bundle branch, changes in the T-wave amplitude, elevation in the ST interval. An intravenous infusion of ethanol potentiated those changes. The impairment of atrioventricular conduction occurred more frequently after administration of ethanol jointly with amitriptyline than with imipramine. Physostigmine salicylate elevated the depressed arterial blood pressure, aggravated the impairment of conduction and potentiated rhythm disturbances caused by the interaction of ethanol with antidepressants. In the above interactions with ethanol imipramine was less toxic than amitriptyline.
Polakowski
P
P
Department of Pharmacology, Medical Academy, Lódź, Poland.
Darzynkiewicz-Czernik
D
D
Kubik-Bogucka
E
E
Dzielska-Olczak
M
M
D000639:Amitriptyline / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002496:Central Venous Pressure / Q000187:drug effects*; D004562:Electrocardiography; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D007099:Imipramine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010830:Physostigmine / Q000494:pharmacology; D011817:Rabbits
D000639:Amitriptyline; D000431:Ethanol; D010830:Physostigmine; D007099:Imipramine