[Effect of glycerin on the biosynthesis of heliomycin by Streptomyces olivocinereus].
Glycerol as the sole carbon source was added to the medium or biosynthesis of heliomycin by Streptomyces olivocinereus and the effect of its concentration on the culture growth and antibiotic production was studied. The culture growth and the amount of the antibiotic synthesized per 1 unit of the fermentation broth were limited by glycerol added in quantities of 0.05 to 1 per cent. Further increasing of the glycerol concentration had no significant effect on the culture growth and antibiotic biosynthesis. The amount of the antibiotic synthesized per 1 unit of the mycelial mass relatively slightly depended on the glycerol concentration. The rate of glycerol consumption by the young 24-hour culture in batch fermentations markedly exceeded that of glycerol consumption by the 48-hour culture. The younger mycelium significantly increased its rate of glycerol consumption when the initial concentration was increased whereas the rate of glycerol consumption by the more mature mycelium did not depend on the initial concentration of the carbon source (within 0.5-2 per cent). The rate of heliomycin biosynthesis practically slightly depended on the initial concentration of glycerol.
Deianova
O A
OA
Kirillova
N P
NP
Sokolova
E G
EG
Vinogradova
K A
KA
D000900:Anti-Bacterial Agents / Q000378:metabolism; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D005990:Glycerol / Q000008:administration & dosage / Q000494:pharmacology*; D066298:In Vitro Techniques; D011083:Polycyclic Compounds / Q000378:metabolism*; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D011083:Polycyclic Compounds; C007912:heliomycin; D005990:Glycerol
Vliianie glitserina na biosintez geliomitsina ku'lturoĭ Streptomyces olivocinereus.