title: [SPECT measurement of cerebral hemodynamics in transient ischemic attack patients--evaluation of pathogenesis and detection of misery perfusion].
abstract: To evaluate the cerebral hemodynamics and the pathogenesis by regional cerebral blood flow (rCBF) and regional cerebral blood volume (rCBV), 42 transient ischemic attack (TIA) patients and 9 normal volunteers were studied using SPECT. We classified these patients into Group A (n = 23: no occlusion or stenosis of the internal carotid or middle cerebral artery; non large vessel disease) and Group B (n = 19: chronic occlusion or severe stenosis of the internal carotid or middle cerebral artery; large vessel disease). We obtained rCBF with 133Xe inhalation and rCBV with 99mTc-red blood cells. Of 9 normal volunteers aged 43-70 yr (mean age 59.8 +/- 8.3 yr), the mean rCBF was 45.8 +/- 5.1 (ml/100 g brain/min), the mean rCBV was 4.0 +/- 0.4 (ml/100 g brain). The examination was done by comparing the values of the affected hemispheres of Group A and Group B patients with the mean rCBF and the mean rCBV of normal volunteers. Eleven out of Group A patients and 15 out of Group B patients showed decreased rCBF. But of those patients, no patients of Group A showed increased rCBV and 6 out of 19 Group B patients showed increased rCBV. Thromboembolic mechanism which is of Group A patients and Group B patients without increased rCBV, and hemodynamic mechanism which is of Group B patients with increased rCBV were considered as the main cause of TIA. Decreased rCBF and increased rCBV in Group B patients can be assumed as the misery perfusion as reported in PET studies.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.forename: H
authors.initials: H
authors.lastname: Toyama
authors.forename: G
authors.initials: G
authors.lastname: Takeshita
authors.forename: A
authors.initials: A
authors.lastname: Takeuchi
authors.forename: K
authors.initials: K
authors.lastname: Ejiri
authors.forename: H
authors.initials: H
authors.lastname: Maeda
authors.forename: K
authors.initials: K
authors.lastname: Katada
authors.forename: S
authors.initials: S
authors.lastname: Koga
authors.forename: N
authors.initials: N
authors.lastname: Ishiyama
authors.forename: T
authors.initials: T
authors.lastname: Kanno
mesh_terms: D000328:Adult; D000368:Aged; D001810:Blood Volume; D001921:Brain / Q000000981:diagnostic imaging*; D002545:Brain Ischemia / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D006801:Humans; D008875:Middle Aged; D014055:Tomography, Emission-Computed; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes