title: The herbal medicine tian ma gou teng yen alters the development of high blood pressure in the spontaneously hypertensive rat.
abstract: In this study, the effect of the herbal prescription Tian Ma Gou Teng Yen (TGY), which is traditionally used to treat certain diseases associated with elevated arterial pressure (AP), on the general development of hypertension was investigated in the spontaneously hypertensive rat (SHR). An aqueous extract of TGY was given orally (0.5 ml/100g body weight) to 5 week old SHR twice a day for six consecutive days followed by one day without herbal therapy. The herbal prescription was administered until the SHR were 16 weeks of age. Administration of TGY significantly altered the development and prevented hypertension in SHR. On the other hand, heart rate, body weight, food and water intake, and urine volume and electrolytes were not altered. These data suggest that the effect of TGY on AP was through an action of TGY on sympathetic vasomotor activity.
authors.affiliation: Department of Physiology, University of Western Ontario, London, Canada.
authors.forename: T X
authors.initials: TX
authors.lastname: Zhang
authors.forename: Y F
authors.initials: YF
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Ciriello
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006973:Hypertension / Q000517:prevention & control*; D007668:Kidney / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D011918:Rats, Inbred SHR; D014563:Urodynamics / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D010936:Plant Extracts