title: Assessment of haemolytic and thromboembolic potentials--from CFD studies of Starr-Edwards cardiac valve prostheses.
abstract: Quantitative assessments of haemolysis, thromboembolism and endothelial damage are established using computational fluid dynamics and documented threshold values. The régime studied was steady forward (systolic) flow through a fully open Starr-Edwards model 1260 ball valve, in an aortic shaped chamber. Modelling was carried out using finite difference techniques for turbulent, Newtonian flow. Haemolysis was not predicted "in-bulk", but a haemolytic potential as high as 30% was suggested at prosthetic surfaces. Also a 10% thromboembolic potential and a 6% potential for endothelium damage were noted.
authors.forename: G D
authors.initials: GD
authors.lastname: Tansley
authors.forename: J
authors.initials: J
authors.lastname: Mazumdar
authors.forename: B J
authors.initials: BJ
authors.lastname: Noye
authors.forename: I H
authors.initials: IH
authors.lastname: Craig
authors.forename: K
authors.initials: K
authors.lastname: Thalassoudis
mesh_terms: D001021:Aortic Valve; D004730:Endothelium, Vascular / Q000293:injuries*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006461:Hemolysis; D006801:Humans; D008433:Mathematics; D015233:Models, Statistical; D012016:Reference Values; D013923:Thromboembolism / Q000209:etiology*