title: Synthesis and antiviral evaluation of 6-p-ethylphenyl-5H-pyrrolo [3,4-b]pyridine-5,7-dione.
abstract: The synthesis of 6-(p-ethylphenyl)-5H-pyrrolo [3,4-b]pyridine-5,7-dione is described. The compound has been studied for its in vitro activity on RNA-containing influenza viruses types A and B. The preliminary results indicate that the compound has a significant antiviral activity against influenza viruses types A and B at concentrations at which no cytotoxic effects on MRC-5 cells in tissue culture are present.
authors.affiliation: Department of Biology, College of Education, University of Mosul, Iraq.
authors.forename: L J
authors.initials: LJ
authors.lastname: Rashan
authors.forename: B A
authors.initials: BA
authors.lastname: Ahmed
authors.forename: S H
authors.initials: SH
authors.lastname: Hussein
authors.forename: R
authors.initials: R
authors.lastname: al-Khayat
authors.forename: L
authors.initials: L
authors.lastname: al-Omar
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D009980:Influenza A virus / Q000187:drug effects; D009981:Influenza B virus / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D011725:Pyridines; D011760:Pyrrolidinones; C062381:6-(4-ethylphenyl)-5H-pyrrolo(3,4-b)pyridine-5,7-dione