title: Anti-plasmin inhibitor. V. Structures of novel dimeric eckols isolated from the brown alga Ecklonia kurome OKAMURA.
abstract: 6,6'-Bieckol (1), 2-O-(2,4,6-trihydroxyphenyl)-6,6'-bieckol (4), and 8,8'-bieckol (2), bispolyphenols with a dibenzo-1,4-dioxin skeleton, have been isolated as potent anti-plasmin inhibitors from the brown alga Ecklonia kurome OKAMURA. Their structures have been determined to be dimers of eckol linked at the C-6 or C-8 positions, through an aryl-aryl bond on the basis of spectral data. Their inhibitory actions on anti-plasmins (alpha 2-macroglobulin and alpha 2-plasmin inhibitor) and some proteases have been examined.
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuyama
authors.forename: M
authors.initials: M
authors.lastname: Kodama
authors.forename: I
authors.initials: I
authors.lastname: Miura
authors.forename: Z
authors.initials: Z
authors.lastname: Kinzyo
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Nakayama
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D000933:Antifibrinolytic Agents / Q000037:antagonists & inhibitors*; D055598:Chemical Phenomena; D002621:Chemistry; D004147:Dioxins / Q000302:isolation & purification / Q000494:pharmacology*; D056890:Eukaryota / Q000032:analysis*; D000459:Phaeophyceae / Q000032:analysis*; D011480:Protease Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000933:Antifibrinolytic Agents; D004147:Dioxins; D011480:Protease Inhibitors; C062360:6,6'-bieckol; C062361:2-O-(2,4,6-trihydroxyphenyl)-6,6'-bieckol; C062362:8,8'-bieckol