[The cytomorphological characteristics of hemopoiesis and of the organs of immunogenesis in exposure to thymus and bone marrow peptides during hematopoietic depression].
The effects of thymic peptide (thymalin), bone marrow peptide (haemalin) and a complex compound (thymohaemin) on the haematopoiesis and immunity were studied in the experimental model of the induced haematopoiesis depression. Lymphopoiesis stimulation in the bone marrow was provoked by thymalin and granulopoiesis stimulation by haemalin. Simultaneously the restoration of a number of both T- and B-lymphocytes in the thymus was observed. Thymohaemin resulted in the restoration of practically all peripheral blood and bone marrow indexes as well as content of T- and B-lymphocytes in both central and peripheral immunogenetic organs. Likewise the use of the thymus and bone marrow peptide preparations facilitated the restoration of non-specific resistance which was evaluated by means of an integral index--lysosomal cation test. The results allow us to recommend the above preparations for a clinical trial in the haematopoiesis depletion.
Khmel'nitskiĭ
O K
OK
Khavinson
V Kh
VKh
Zhukhina
G E
GE
Kotov
V A
VA
Seryĭ
S V
SV
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D001853:Bone Marrow; D006168:Guinea Pigs; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D007107:Immune System / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D007111:Immunity, Cellular / Q000187:drug effects / Q000528:radiation effects; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D013950:Thymus Gland; D013951:Thymus Hormones / Q000494:pharmacology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D013951:Thymus Hormones; C032805:thymalin; C046163:hemalin
Tsitomorfologicheskaia kharakteristika gemopoéza i organov immunogeneza pri vozdeĭstvii peptidov timusa i kostnogo mozga v usloviiakh depressii krovetvoreniia.