Copper complexes stimulate hemopoiesis and lymphopoiesis.
Copper(II)2(3,5-diisopropylsalicylate)4 [Cu(II)2(3,5-DIPS)4] is a synthetic copper complex with a variety of effects, including radiation recovery, anti-inflammatory, and accelerated wound healing activities. When C57BL/6 mice were injected subcutaneously with 80 mumol/kg Cu(II)2(3,5-DIPS)4 their spleens significantly enlarged. This splenomegally lasted for at least 3 weeks and was accompanied by increased myelopoiesis in the spleen. Bone marrow had no significant change in cellularity or myelopoiesis. The treatment with Cu(II)2(3,5-DIPS)4 had only minor effects on the ability of spleen cells to respond to mitogenic or antigenic stimulation. Cu(II)2(3,5-DIPS)4 did stimulate lymphopoiesis, since it accelerated the recovery of immune reactivity following exposure to 8 Gy whole body irradiation. Copper levels in the spleens and bone marrow of unirradiated mice treated with Cu(II)2(3,5-DIPS)4 were not significantly elevated 24 hr after treatment and copper levels were transiently reduced 7 days after treatment.
Soderberg
L S
LS
Department of Microbiology and Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock 72205.
Barnett
J B
JB
Sorenson
J R
JR
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism*; D003114:Colony-Forming Units Assay; D003300:Copper / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D012459:Salicylates / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism*
D012459:Salicylates; C030865:copper bis(3,5-diisopropylsalicylate); D003300:Copper