title: Chronic restraint stress does not sensitize a muscarinic mechanism.
abstract: Describing the neurobiological changes which may explain the link between chronic stressors and the epidemiological association of recurrent episodes of depression in patients with unipolar or bipolar illness is a goal of psychiatric research. Disorders of mood may involve hyperactivity of central muscarinic mechanisms. Chronic forced swim stress and footshock produce supersensitivity to a muscarinic agonist. Chronic prolonged restraint is a severe stressor for the rat and activates the hypothalamic-pituitary-adrenal (HPA) axis. This report presents data suggesting that this stressor does not, unlike forced swim stress and footshock, enhance sensitivity to the hypothermic effects of a muscarinic agonist.
authors.affiliation: Department of Psychiatry, Ohio State University, Columbus 43210-1228.
authors.forename: D D
authors.initials: DD
authors.lastname: Flemmer
authors.forename: S C
authors.initials: SC
authors.lastname: Dilsaver
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D008297:Male; D010095:Oxotremorine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000503:physiopathology*
chemical_list: D010095:Oxotremorine