title: The effect of inorganic phosphate on the production of avermectin in Streptomyces avermitilis.
abstract: The effect of phosphate on the production of avermectin B1a, growth and utilization of glucose in the course of cultivation of Streptomyces avermitilis on a complex and chemically defined medium has been studied. Phosphate added at the beginning of cultivation at 1-20 mmol/l did not distinctly affect the production of secondary metabolite. From the results it follows that the biosynthesis of avermectin tolerates high concentrations of phosphate in the medium.
authors.affiliation: Institute of Microbiology, Czechoslovak Academy of Sciences, Prague.
authors.forename: E
authors.initials: E
authors.lastname: Curdová
authors.forename: V
authors.initials: V
authors.lastname: Jechová
authors.forename: J
authors.initials: J
authors.lastname: Zima
authors.forename: Z
authors.initials: Z
authors.lastname: Vanĕk
mesh_terms: D000871:Anthelmintics / Q000378:metabolism*; D003470:Culture Media; D004271:DNA, Fungal / Q000032:analysis; D005285:Fermentation; D005947:Glucose / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000378:metabolism; D010710:Phosphates / Q000494:pharmacology*; D013302:Streptomyces / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development / Q000378:metabolism
chemical_list: D000871:Anthelmintics; D003470:Culture Media; D004271:DNA, Fungal; D010710:Phosphates; D007559:Ivermectin; C019264:avermectin; D005947:Glucose