Isolation of inhibitors of adenylate cyclase from dan-shen, the root of Salvia miltiorrhiza.
The effect of dan-shen extract, the root of Salvia miltiorrhiza, on adenylate cyclase was investigated in both rat brain and rat erythrocytes. The EtOAc fraction of the MeOH extract was proved to have significant inhibitory activity. Potent inhibitory principles in the EtOAc fraction were isolated and identified as 4 polyphenolic acids, rosemarinic acid, lithospermic acid, and their methyl ester derivatives.
Kohda
H
H
Takeda
O
O
Tanaka
S
S
Yamasaki
K
K
Yamashita
A
A
Kurokawa
T
T
Ishibashi
S
S
D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000097:blood; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000067956:Adenylyl Cyclase Inhibitors; D004365:Drugs, Chinese Herbal; D000262:Adenylyl Cyclases