[Changes in the ratio of secreted thyroid hormones under the action of adrenaline, propranolol and thyrotropic hormone].
The injection of 0.5 mM of adrenalin and 3.3 X 10(-3) M of propranolol in the thyroid artery of the thyroid lobe perfused in a thermostatic chamber (37 degrees C) 1h after the beginning of perfusion caused a decrease in the index of thyroid deiodination by 48 and 37%, respectively. Adrenalin injection 2 h after TSH lowered the stimulating effect of the latter on thyroxine thyroid conversion. A conclusion is made that adrenalin testing can suppress the activity of thyroid conversion of T4 into T3 and decrease the activity of TSH-stimulated deiodination.
Turakulov
Ia Kh
IaKh
Burikhanov
R B
RB
Tashkhodzhaeva
T P
TP
Ismailov
S I
SI
Artykbaeva
G M
GM
D000818:Animals; D004285:Dogs; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D008297:Male; D010477:Perfusion / Q000379:methods; D011433:Propranolol / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism; D013963:Thyroid Hormones / Q000097:blood / Q000378:metabolism*; D013972:Thyrotropin / Q000494:pharmacology*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D013963:Thyroid Hormones; D014284:Triiodothyronine; D013972:Thyrotropin; D011433:Propranolol; D013974:Thyroxine; D004837:Epinephrine
Izmenenie sootnosheniia sekretiruemykh tireoidnykh gormonov pod deĭstviem adrenalina, propranolola i tireotropnogo gormona.