[The effect of dihydropyridines on the strontium and calcium content in frog muscle].
2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(O-difluromethoxyphenyl)-1,4- dihydropyridine (ryodipine) (2 x 10(-4) M) significantly blocks the resting Sr++ uptake in sartorius and iliofibularis muscles of Rana temporaria without changes in Ca++ and Mg++ content. Dihydropyridine CGP (2.10(-4) M) increased both [Sp++] and [Ca++] (mumol/g dr. w.) by about 20 and 13%, respectively, as compared with paired control muscles, whereas [Mg++] remained unaffected. The [Sr++] changes are interpreted as specific dihydropyridine-effect on the Ca(++)-channels in the muscle membrane.
Shvinka
N E
NE
Velena
A Kh
AKh
Skrastyn'sh
I P
IP
Dubur
G Ia
GIa
Ivakhniuk
I S
IS
D000818:Animals; D002118:Calcium / Q000032:analysis / Q000378:metabolism*; D004095:Dihydropyridines / Q000494:pharmacology*; D066298:In Vitro Techniques; D007552:Isotonic Solutions; D009132:Muscles / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D009543:Nifedipine / Q000031:analogs & derivatives / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011896:Rana temporaria; D000077331:Ringer's Solution; D013324:Strontium / Q000032:analysis / Q000378:metabolism*
D004095:Dihydropyridines; D007552:Isotonic Solutions; D011725:Pyridines; D000077331:Ringer's Solution; C040525:CGP 28392; D009543:Nifedipine; D002118:Calcium; C045912:ryodipine; D013324:Strontium
Vliianie digidropiridinov na soderzhanie strontsiia i kal'tsiia v mushtse liagushki.