title: Benzylpiperazine derivatives. XI. Synthesis of compounds related to the metabolites of 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796).
abstract: The metabolites of 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796, 1), a cerebral vasodilator, and related compounds were synthesized to confirm the proposed structures. The structures of the metabolites (3-5) in rats were identified by means of synthesis of the authentic compounds.
authors.forename: H
authors.initials: H
authors.lastname: Ohtaka
authors.forename: M
authors.initials: M
authors.lastname: Hori
authors.forename: R
authors.initials: R
authors.lastname: Iemura
authors.forename: H
authors.initials: H
authors.lastname: Yumioka
mesh_terms: D000818:Animals; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010879:Piperazines / Q000138:chemical synthesis* / Q000378:metabolism; D051381:Rats; D014665:Vasodilator Agents / Q000138:chemical synthesis*
chemical_list: D010879:Piperazines; D014665:Vasodilator Agents; C052424:lomerizine