title: Dog bone less osteogenetic than rat bone. Bone-matrix transplants in nude rats.
abstract: Demineralized bone matrix and bone-matrix gelatin prepared from cortical rat bone, and from cortical and cancellous canine bone were implanted into muscle pouches of nude rats for 6 weeks. Evaluation was done by histology, histomorphometry, and determination of alkaline phosphatase. Rat matrix consistently induced new bone and high phosphatase levels. Canine matrix induced but small amounts of bone and lower phosphatase levels, with cortical matrix somewhat more inductive than cancellous matrix; demineralized cancellous bone matrix from the dog was the only material tested not showing any inductivity. Irrespective of bone type or species, gelatin had clearly higher induction capacity than demineralized bone matrix.
authors.affiliation: Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria.
authors.forename: N
authors.initials: N
authors.lastname: Schwarz
authors.forename: H P
authors.initials: HP
authors.lastname: Dinges
authors.forename: A
authors.initials: A
authors.lastname: Schiesser
authors.forename: H
authors.initials: H
authors.lastname: Redl
authors.forename: G
authors.initials: G
authors.lastname: Schlag
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001857:Bone Matrix / Q000201:enzymology / Q000637:transplantation*; D004285:Dogs; D008297:Male; D010012:Osteogenesis / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011923:Rats, Nude; D013045:Species Specificity; D016042:Transplantation, Heterotopic
chemical_list: D000469:Alkaline Phosphatase