[Pharmacokinetic properties of pancreatic and microbial ribonucleases].
Pharmacokinetic properties of pancreatic RNAase (RNAase I), RNAase of Bacillus intermedius (RNAase Bi) and RNAase of Streptomyces rimosus (RNAase Sr) were studied on albino rats. RNAase Bi was shown to be characterized by a higher rate and level of absorption into the systemic blood flow, higher retention time, lower elimination from the kidneys and tissues of the peripheral chamber (skeletal muscles) and higher distribution in the other animal organs such as the heart, spleen and brain. It was concluded by the experimental results that the higher antiviral efficacy of RNAase Bi (RNAase Bi greater than RNAase Sr greater than RNAase I), as was known from the literature data, and the ability to stimulate the immunity correlated with higher biological availability of the enzyme in the animals and could be due to its pharmacokinetic properties.
Kurinenko
B M
BM
Kupriianov-Ashin
E G
EG
Valnullina
S F
SF
D000818:Animals; D001407:Bacillus / Q000201:enzymology*; D001682:Biological Availability; D008297:Male; D009132:Muscles / Q000201:enzymology; D051381:Rats; D012259:Ribonuclease, Pancreatic / Q000493:pharmacokinetics*; D012260:Ribonucleases / Q000493:pharmacokinetics*; D013302:Streptomyces / Q000201:enzymology*; D013997:Time Factors; D014781:Viscera / Q000201:enzymology
D012260:Ribonucleases; D012259:Ribonuclease, Pancreatic
Farmakokineticheskie svoĭstva pankreaticheskoĭ i mikrobnykh RNKaz.