[The main pathogenetic mechanisms of disorders of the detoxication function of the liver in endogenous toxemia of various etiologies].
The mechanisms of cell proliferative activity regulation under the effect of growth factors, mitogens, virus transformation, etc. were analyzed. Changes in the location of cAMP-dependent protein kinase caused by these factors, the effect of the nerve growth factor on the activities of protein kinase and high-affinity ATPase, and the mechanism of antiproliferative action of staphylococcal enterotoxin A were specified. Data on receptor-independent intracellular penetration of protein factors hydrophobized by fatty acid residues are overviewed.
Krakovskiĭ
M E
ME
Ashirmetov
A Kh
AKh
D000818:Animals; D001711:Biotransformation / Q000502:physiology*; D002056:Burns / Q000150:complications / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000172:deficiency*; D004731:Endotoxins / Q000378:metabolism*; D007415:Intestinal Obstruction / Q000150:complications / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D010019:Osteomyelitis / Q000150:complications / Q000378:metabolism; D051381:Rats; D013203:Staphylococcal Infections / Q000150:complications / Q000378:metabolism; D014115:Toxemia / Q000209:etiology*
D004731:Endotoxins; D003577:Cytochrome P-450 Enzyme System
Osnovnye patogeneticheskie mekhanizmy narusheniia detoksikatsionnoĭ funktsii pecheni pri éndogennykh intoksikatsiiakh razlichnogo geneza.