[Synthesis of derivatives of 2,4-bis(arylmethino)-8-butyl-8- azabicyclo[3.2.1]octan-3-one].
In the frame-work of continued search for novel compounds with potential cholagogic or antitumour activity, some derivatives of 2,4-bis-(arylmethino)-8-butyl-8-azabicyclo[3.2.1]octan-3-one were synthesized. 8-Butyl-8-azabicyclo[3.2.1]octan-3-one was condensed with selected tolualdehydes, methoxybenzaldehydes and chlorobenzaldehydes, as well as with piperonal, furfural, dimethylaminobenzaldehyde, 3-pyridine-carboxaldehyde and 4-pyridine-carboxaldehyde. Products of these reactions were isolated in the form of free bases or their hydrochlorides. The obtained compounds were subjected to pharmacological studies. Two as yet investigated compounds failed to induce statistically significant increase in the volume of secreted bile, but one of them was found to display cholinergic activity.
Gutkowska
B
B
Baranowski
A
A
Herold
F
F
D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000378:metabolism; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D002756:Cholagogues and Choleretics; D004353:Drug Evaluation, Preclinical; D008297:Male; D009795:Octanes / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats
D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D002756:Cholagogues and Choleretics; D009795:Octanes
Syntezy pochodnych 2,4-bis(arylometino)-8-butylo-8-azabicyklo [3.2.1] oktan-3-onu.