title: [An evaluation of methods for the quantitative determination of praziquantel as a substance].
abstract: Feasibility of quantitative determination of a new helminthicide prasiquantel as a substance by spectral and chemical analytic procedures has been investigated. Chemical methods based on nitrogen measurement in the samples were shown to lack precision which is obligatory for drug analysis. The quantitative analytic procedures based on UV spectrophotometry are of low precision and selectivity. Infrared spectroscopy is the only method of prasiquantel assay that meets the requirements for drug substance measurement.
authors.forename: B V
authors.initials: BV
authors.lastname: Lopatin
authors.forename: N K
authors.initials: NK
authors.lastname: Bebris
authors.forename: N B
authors.initials: NB
authors.lastname: Lopatina
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D005069:Evaluation Studies as Topic; D011223:Praziquantel / Q000032:analysis*; D013055:Spectrophotometry, Infrared / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
chemical_list: D011223:Praziquantel
vernacular_title: Otsenka metodov kolichestvennogo opredeleniia prazikvantelia v substantsii.