[Synthesis of mitochondrial proteins in isoproterenol-induced damage of the rat myocardium].
A rate of 14C-amino acids incorporation into mitochondrial proteins was studied during necrosis of myocardium developed after intraperitoneal injection of (-)isoproterenol to 1-, 3- and 6 months old rats. The rate of label incorporation into the outer membranes fraction was decreased in all the age groups studied, whereas incorporation of the label into the fraction of inner membranes was increased in myocardium of 1 month old rats and decreased in other age groups. Proteins of mitochondrial inner membrane were fractionated by means of electrophoresis in 10% polyacrylamide gel. In the group of 3 months old animals 23 fractions were detected, while only 18 fractions were found in 1- and 6 months old rats.
Gevorkian
G A
GA
Kanaian
A S
AS
Voskanian
L O
LO
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism*; D007545:Isoproterenol / Q000633:toxicity*; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis*; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D051381:Rats
D008565:Membrane Proteins; D007545:Isoproterenol
Sintez mitokhondrial'nykh belkov pri izoproterenolovom povrezhdenii miokarda krys.