[Fulminant hepatitis induced by disulfiram in a patient with alcoholic cirrhosis. Survival after liver transplantation].
Fulminant hepatitis was observed in a 44-year-old patient with cirrhosis, 38 days after the beginning of a treatment by disulfiram. Hepatitis was associated with fever and hypereosinophilia. Liver transplantation was performed with success. We reviewed 15 previously published cases of disulfiram-induced hepatitis. They occurred from 10 to 180 days after the beginning of the treatment by disulfiram, aminotransferases were increased whereas alkaline phosphatases were not markedly changed; there was either focal or widespread necrosis. Fulminant hepatitis was observed mainly in patients with alcoholic chronic liver disease or in patients who continued to ingest disulfiram while jaundice was already present. An immunoallergic mechanism is thought to be responsible for disulfiram-induced hepatitis.
Vanjak
D
D
Service de Réanimation et de Médecine d'Urgence, Centre Hospitalier Emile-Roux, Eaubonne.
Samuel
D
D
Gosset
F
F
Derrida
S
S
Moreau
R
R
Soupison
T
T
Soulier
A
A
Bismuth
H
H
Sicot
C
C
D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D004221:Disulfiram / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications* / Q000188:drug therapy; D016031:Liver Transplantation; D008297:Male
D004221:Disulfiram
Hépatite fulminante au disulfirame chez un malade atteint de cirrhose alcoolique. Survie après transplantation hépatique.