Metabolism of 1H-benzotriazolecarboxylic acids in vitro and in vivo.
The 1H-benzotriazolecarboxylic acids 1 and 2 were stable towards oxidative metabolism as well in vitro as in vivo. In the in vivo studies 2.25% of the ester glucuronide of 1H-benzotriazole-5-carboxylic acid was found in urine.
Hoffmann
H
H
Jacobi
S
S
D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014230:Triazoles / Q000378:metabolism*
D014230:Triazoles; C062152:1H-benzotriazole-5-carboxylic acid; C062153:1H-benzotriazole-7-carboxylic acid