title: Phosphorus-31 magnetic resonance spectroscopy in humans by spectroscopic imaging: localized spectroscopy and metabolite imaging.
abstract: In in vivo phosphorus magnetic resonance spectroscopy (MRS), spectroscopic imaging (SI) can be used as a flexible localization technique, producing spectra from multiple volumes in a single examination. Presented here are phosphorus SI studies of human organs in which a selective-volume SI reconstruction was used rather than the usual array-format SI reconstruction. A linear predictor technique was used to estimate the initial points of the free induction decay missing because of the delay needed for phase-encoding gradients, significantly reducing the baseline artifacts which commonly complicate interpretation of SI spectra. In studies of heart, brain, liver, and kidney, the performance of SI was found to compare favorably with that of ISIS. SI phosphorus metabolite intensity images from a brain tumor patient were obtained at 2 X 2-cm in-plane resolution (with "slice" thickness of roughly 16 cm, determined by coil sensitivity) in 34 min, demonstrating the feasibility of obtaining clinically useful metabolite images in clinically reasonable examination times.
authors.affiliation: Philips Medical Systems, Inc., San Francisco, California.
authors.forename: D B
authors.initials: DB
authors.lastname: Twieg
authors.forename: D J
authors.initials: DJ
authors.lastname: Meyerhoff
authors.forename: B
authors.initials: B
authors.lastname: Hubesch
authors.forename: K
authors.initials: K
authors.lastname: Roth
authors.forename: D
authors.initials: D
authors.lastname: Sappey-Marinier
authors.forename: M D
authors.initials: MD
authors.lastname: Boska
authors.forename: J R
authors.initials: JR
authors.lastname: Gober
authors.forename: S
authors.initials: S
authors.lastname: Schaefer
authors.forename: M W
authors.initials: MW
authors.lastname: Weiner
mesh_terms: D001254:Astrocytoma / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism; D005583:Fourier Analysis; D006801:Humans; D007668:Kidney / Q000378:metabolism; D016014:Linear Models; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009206:Myocardium / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism*
chemical_list: D010758:Phosphorus