Monoclonal antibody-coated magnetite particles as contrast agents in magnetic resonance imaging of tumors.
A highly specific and powerful magnetic resonance imaging contrast agent has been prepared by coating magnetite (Fe3O4) particles with monoclonal antibodies directed against a tumor antigen. The preparation maintains both the immunoreactivity of the monoclonal antibody and the full relaxing capability of the magnetite particle. MRI image contrast by spin-echo methods can be easily induced in a concentration range of 1-10 nM of the antibody-coated magnetite particles.
Cerdan
S
S
Biocenter of the University of Basel, Switzerland.
Lötscher
H R
HR
Künnecke
B
B
Seelig
J
J
D000818:Animals; D000911:Antibodies, Monoclonal; D002277:Carcinoma / Q000175:diagnosis; D002460:Cell Line; D003110:Colonic Neoplasms / Q000175:diagnosis; D052203:Ferrosoferric Oxide; D006801:Humans; D007501:Iron; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000175:diagnosis*; D010087:Oxides; D051381:Rats
D000911:Antibodies, Monoclonal; D010087:Oxides; D007501:Iron; D052203:Ferrosoferric Oxide