Structure and synthesis of FK409, a novel vasodilator isolated from Streptomyces as a semi-artificial fermentation product.
The structures of FK409 (1), a semi-artificial fermentation product and its precursor (2) have been established on the basis of chemical and spectroscopic evidence and confirmed by conversion of 2 to 1 via a synchronous nitrosation-nitration reaction.
Hino
M
M
Takase
S
S
Itoh
Y
Y
Uchida
I
I
Okamoto
M
M
Hashimoto
M
M
Kohsaka
M
M
D005285:Fermentation; D009574:Nitro Compounds / Q000032:analysis* / Q000138:chemical synthesis; D013302:Streptomyces / Q000378:metabolism*; D014665:Vasodilator Agents / Q000032:analysis* / Q000138:chemical synthesis
D009574:Nitro Compounds; D014665:Vasodilator Agents; C061872:FK 409