title: Preproenkephalin mRNA expression in nucleus caudalis neurons is enhanced by trigeminal stimulation.
abstract: Electrical stimulation of trigeminal afferents increases expression of preproenkephalin mRNA in neurons of laminae I and II of the trigeminal nucleus caudalis in animals sacrificed 6 hours after the end of stimulation. More neurons express, and positive cells express at higher levels. These neurons thus express the mRNA corresponding to a major pain-modulating neurotransmitter gene with significant input-related plasticity.
authors.affiliation: Gene Neuroscience Unit, ARC/NIDA, Johns Hopkins School of Medicine, Baltimore, MD 21224.
authors.forename: T
authors.initials: T
authors.lastname: Nishimori
authors.forename: M G
authors.initials: MG
authors.lastname: Buzzi
authors.forename: M A
authors.initials: MA
authors.lastname: Moskowitz
authors.forename: G R
authors.initials: GR
authors.lastname: Uhl
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D004745:Enkephalins / Q000378:metabolism*; D005786:Gene Expression Regulation; D008297:Male; D009693:Nucleic Acid Hybridization; D011498:Protein Precursors / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012668:Trigeminal Ganglion / Q000378:metabolism* / Q000502:physiology
chemical_list: D004745:Enkephalins; D011498:Protein Precursors; D012333:RNA, Messenger; C033660:preproenkephalin