title: [The efficacy of vaccination and serotherapy in tick-borne encephalitis in the Maritime Territory].
abstract: The use of different vaccines manufactured in the USSR under the condition of the Far East has revealed that killed vaccines do not produce a protective effect, sufficient for the prophylaxis of tick-borne encephalitis (TBE). This is probably due to the circulation of a highly virulent population of TBE virus at the Territory. This virus population may produce a severe course of infection and aggravate the clinico-epidemiological characteristics of the effectiveness of vaccines. Besides, low levels of specific and nonspecific humoral resistance factors in the residents of the Far East, especially in spring and summer, contribute to this fact. The negative effect of specific serotherapy for persons over 40 years of age has been established.
authors.forename: G N
authors.initials: GN
authors.lastname: Leonova
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D004341:Drug Evaluation; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control* / Q000628:therapy; D006801:Humans; D007117:Immunization, Secondary; D008875:Middle Aged; D012800:Siberia / Q000453:epidemiology; D015164:Vaccines, Inactivated / Q000276:immunology / Q000627:therapeutic use; D014765:Viral Vaccines / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D015164:Vaccines, Inactivated; D014765:Viral Vaccines
vernacular_title: Effektivnost' vaktsinatsii i seroterapii pri kleshchevom éntsefalite v Primorskom krae.