title: Ocular inflammatory changes in established multiple sclerosis.
abstract: Fifty consecutive patients with clinically definite multiple sclerosis were studied to assess the prevalence of concomitant uveitis. Asymptomatic ocular inflammatory changes were found in nine patients (18%) and appeared to show a positive correlation with severe and progressive disease. Conversely uveitis was uncommon in the presence of established optic atrophy which suggests a negative influence on its pathogenesis. In the absence of optic atrophy inflammatory changes in the eye may be a valuable index of disease activity.
authors.affiliation: National Hospital for Nervous Diseases, London, United Kingdom.
authors.forename: E M
authors.initials: EM
authors.lastname: Graham
authors.forename: D A
authors.initials: DA
authors.lastname: Francis
authors.forename: M D
authors.initials: MD
authors.lastname: Sanders
authors.forename: P
authors.initials: P
authors.lastname: Rudge
mesh_terms: D000293:Adolescent; D000328:Adult; D001284:Atrophy / Q000209:etiology; D002908:Chronic Disease; D005123:Eye / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D009887:Ophthalmoscopy; D014605:Uveitis / Q000209:etiology* / Q000473:pathology