title: Effects of lung surgery and one-lung ventilation on pulmonary arterial pressure, venous admixture and immediate postoperative lung function.
abstract: We studied 17 patients, with unilateral lesions in lung or thoracic wall, during thoracotomy performed in the full lateral position. Balanced anaesthesia was used with pethidine and 50% nitrous oxide, in oxygen. The procedure included a period of one-lung ventilation (OLV). Haemodynamic and gas exchange measurements were performed before and after pleurotomy, during OLV, after re-expansion of the lung and after closure of the thoracic wall. The function of each lung was assessed separately during the first and last stages. Mean venous admixture was 9-12% before and after OLV and 31% during OLV. There was a positive correlation between venous admixture and pulmonary arterial pressure during OLV. End-tidal PCO2, carbon dioxide elimination and compliance of the operated side were reduced significantly at the end of the procedure; this is consistent with reduced blood flow and increased water content in that lung.
authors.affiliation: Department of Anesthesiology, University Hospital, Lund, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Malmkvist
authors.forename: R
authors.initials: R
authors.lastname: Fletcher
authors.forename: L
authors.initials: L
authors.lastname: Nordström
authors.forename: O
authors.initials: O
authors.lastname: Werner
mesh_terms: D000768:Anesthesia, General; D000769:Anesthesia, Inhalation; D001794:Blood Pressure; D006439:Hemodynamics; D006801:Humans; D008168:Lung / Q000503:physiopathology* / Q000601:surgery; D008171:Lung Diseases / Q000601:surgery*; D010100:Oxygen / Q000097:blood; D011184:Postoperative Period; D011651:Pulmonary Artery / Q000503:physiopathology*; D012121:Respiration, Artificial
chemical_list: D010100:Oxygen