[Modification of the toxic effects of phenylmercury by adaptive reactions of the rat kidney. 2. Adaptation to phenylmercury acetate, cadmium chloride and cupric chloride].
ICO:WIST rats were pretreated over 20 days, using oral administration of subtoxic doses of 1.5 mg/kg body weight of phenylmercury acetate (PMA) 15 mg/kg of CdCl2 and 15 mg/kg of CuCl2, to investigate correlations between nephrotoxic effects of PMA, on the one hand, and buildup through various extraneous substances of adaptive reactivity, on the other. This was followed by application of an acutely toxic dose of 15 mg/kg of PMA. Its effect was compared by morphological and functional investigations with conditions in unchallenged animals. The method, according to all findings, did not cause major renal damage, on completion of PMA, CdCl2, and CuCl2 pretreatment. Nephrotoxic effects induced to pretreated animals (1.5 mg/kg of PMA) by 15 mg/kg of PMA were clearly below those induced to untreated animals. However, PMA effectiveness on kidneys was much higher in animals which had received CdCl2 or CuCl2 pretreatment. Such possible controllability of toxic PMA efficacy through adaptation to various extraneous substances is likely to underline the need for differentiated assessment of progressive and regressive elements related to adaptive reaction.
Solecki
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D000222:Adaptation, Physiological; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride; D003300:Copper / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects*; D010663:Phenylmercury Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D010663:Phenylmercury Compounds; D002104:Cadmium; D003300:Copper; D019256:Cadmium Chloride; C029892:cupric chloride
Beeinflussung toxischer Wirkungen von Phenylquecksilber durch adaptive Reaktionen der Rattenniere. 2. Mitteilung: Anpassung an Phenylquecksilberacetat, Cadmium- und Kupferchlorid.