[Intravenous magnesium administration in bronchial asthma].
The effect of intravenously infused Mg-aspartate hydrochloride (MgAHCl) was studied in 17 asthmatic inpatients. In 6 patients with initial forced vital capacity (FVC) greater than 90% of normal value, there were no significant changes in the lung volumina after 10 mmol of MgAHCl. In 11 patients with initial FVC less than or equal to 90%, the median FVC increased after MgAHCl by 56 to 61% (p less than 0.01), the forced expiratory volume at 1 sec. (FEV1) by 40 to 44% (p less than 0.02) and the peak expiratory flow (PEF) by 45 to 56% (p less than 0.02). No significant changes of respiratory resistance were observed. The average serum concentration of Mg increased by 0.89 to 1.72 mmol/L and decreased to 1.33 mmol/L 20 minutes after the Mg-infusion. Intravenous infusion of Mg produces a significant improvement of FVC, FEV1 and PEF. With its cardioprotective effect and the reduction of bronchial hyperreactivity, Mg could be a valuable method in the treatment of asthmatic patients.
Hauser
S P
SP
Zürcher Hochgebirgsklinik, Clavadel-Davos.
Braun
P H
PH
D000293:Adolescent; D000328:Adult; D000368:Aged; D001224:Aspartic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D004338:Drug Combinations; D006801:Humans; D008176:Lung Volume Measurements; D008274:Magnesium / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged
D004338:Drug Combinations; D001224:Aspartic Acid; D008274:Magnesium
Intravenöse Magnesium-Gabe bei Asthma bronchiale.