Flunarizine does not delay the development of generalized seizures by amygdala kindling.
Adult rats underwent amygdala kindling after the administration of vehicle, flunarizine 20 mg/kg/day, or flunarizine 40 mg/kg/day. Stimuli were delivered thrice daily at current intensities twice after-discharge threshold (ADT). Flunarizine did not alter initial or post-kindling ADT and did not affect the latency (number of stimuli) to the first stage 5 seizure. Apart from a tendency to increase the latency between the first and the 4th stage 5 seizures, flunarizine had little if any effect on amygdala kindling in this protocol.
Trommer
B L
BL
Department of Pediatrics, Evanston Hospital, IL 60201.
Pasternak
J F
JF
D000679:Amygdala; D000818:Animals; D005444:Flunarizine / Q000627:therapeutic use*; D007696:Kindling, Neurologic / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000188:drug therapy*
D005444:Flunarizine