Congenital changes of platelet functions in stroke-prone SHR: aggregability of gel-filtered platelets, PRP and whole blood, and effects of hypotensive treatment.
Platelet aggregation in whole blood, platelet rich plasma, and gel-filtered platelets were markedly attenuated in SHRSP compared with those in age-matched normotensive WKY. The result was consistent with the previous report of washed platelets. Despite prevention of high blood pressure, a long duration of hypotensive treatment only slightly improved aggregability of washed platelets but did not restore it to the range of age-matched WKY platelets. Blood pressure, heart ratios and thrombin-induced washed platelet aggregation were examined in SHRSP, WKY, and the cross (F1: WKY x SHRSP). The higher blood pressure and heart ratios the lower platelet aggregability was observed in the three strains, and there was no overlapping distribution of these values. F1 progeny exhibited intermediate values in blood pressure, heart ratio and platelet aggregability between the parental values. These results suggested that hypofunctions of SHRSP platelet were not secondary changes due to high blood pressure, but primary changes which are genetically linked to high blood pressure.
Ikeda
M
M
University of Shizuoka School of Pharmaceutical Sciences, Japan.
Umegaki
K
K
Takeshita
N
N
Mitsubori
M
M
Tomita
T
T
Tomita
I
I
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D002469:Cell Separation; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000235:genetics; D003433:Crosses, Genetic; D004198:Disease Susceptibility; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000235:genetics; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D011918:Rats, Inbred SHR / Q000097:blood*; D011919:Rats, Inbred Strains / Q000097:blood*; D011921:Rats, Inbred WKY / Q000097:blood
D000959:Antihypertensive Agents