title: The human genes for calbindin 27 and 29 kDa proteins are located on chromosomes 8 and 16, respectively.
abstract: Genomic clones coding for the brain calcium-binding protein, calbindin 29 kDa, were isolated from a human library. A fragment containing exon 2 was used as a probe to investigate the presence of the gene in human x rodent somatic cell hybrids. The gene was unambiguously assigned to chromosome 16. The closely-related calbindin 27 kDa gene was previously assigned to chromosome 8. These two genes, deriving from a common ancestor, thus appear to have been separated during vertebrate evolution.
authors.affiliation: I.R.I.B.H.N., Medical School, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Parmentier
authors.forename: J
authors.initials: J
authors.lastname: Szpirer
authors.forename: G
authors.initials: G
authors.lastname: Levan
authors.forename: G
authors.initials: G
authors.lastname: Vassart
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D064026:Calbindins; D002885:Chromosomes, Human, Pair 16; D002898:Chromosomes, Human, Pair 8; D003001:Cloning, Molecular; D015723:Gene Library; D006801:Humans; D006822:Hybrid Cells; D008970:Molecular Weight; D015183:Restriction Mapping; D064030:S100 Calcium Binding Protein G / Q000235:genetics*
chemical_list: D064026:Calbindins; D064030:S100 Calcium Binding Protein G