Application of an analytical method to calcium acetylhomotaurinate determination in urine.
After urine purification, plasma and urine concentrations of calcium acetylhomotaurinate (Acamprosate, CaAOTA) were determined with a high-performance liquid chromatography method following i.v. administration of the drug in two dogs. Results obtained in serum were in good agreement with those found previously. The CaAOTA urine determination is a promising method to be used in healthy volunteers.
Chabenat
C
C
Laboratoire de Pharmacochimie, Unité d'Enseignement et de Recherche de Médecine Pharmacie de Rouen, Saint-Etienne-du-Rouvray, France.
Ladure
P
P
Moore
N
N
Boucly
P
P
Boismare
F
F
D000077443:Acamprosate; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D013056:Spectrophotometry, Ultraviolet; D013654:Taurine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000652:urine
D013654:Taurine; D000077443:Acamprosate