title: Effects of colostral antibody on susceptibility of calves to Cryptosporidium parvum infection.
abstract: Effects of colostral antibody on susceptibility of calves to Cryptosporidium parvum infection were examined. Six calves were fed pooled colostrum that contained C parvum antibody, 6 times daily (at 4-hour intervals) for 7 days and then milk replacer for 7 days. Colostrum was obtained from healthy cows or cows inoculated parenterally with C parvum oocysts before parturition. Antibody content was determined in serum and colostrum whey, using an ELISA for anticryptosporidia immunoglobulin. Six calves were fed colostrum from healthy cows 1 time, and then milk replacer 6 times daily for 14 days. On day 1, all calves were challenge exposed with C parvum, PO, and were monitored daily for diarrhea and oocyst shedding. Bovine colostrum containing specific antibody to C parvum, at ELISA titers up to 10,240, was not effective in protecting calves against challenge exposure to C parvum.
authors.affiliation: National Animal Disease Center, Agricultural Research Service, Ames, IA 50010.
authors.forename: J A
authors.initials: JA
authors.lastname: Harp
authors.forename: D B
authors.initials: DB
authors.lastname: Woodmansee
authors.forename: H W
authors.initials: HW
authors.lastname: Moon
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D003126:Colostrum / Q000276:immunology*; D003457:Cryptosporidiosis / Q000276:immunology*; D003458:Cryptosporidium / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan