Testicular effects of bis(2-methoxyethyl) ether in the adult male rat.
The onset of testicular pathology in the rat and possible recovery over an 8-week period were evaluated after the administration of up to 20 daily oral doses of bis(2-methoxyethyl) ether (diglyme) at 5.1 mmol/kg bw (684 mg/kg bw). Primary and secondary spermatocyte degeneration and spermatidic giant cells were observed after six to eight treatments. In addition, the testes-to-body weight ratio was significantly reduced by the tenth day of treatment and continued to be depressed eight weeks after discontinuation of the treatment. Testicular LDH-X activity, a pachytene spermatocyte marker enzyme, was significantly decreased in animals by the eighteenth day of treatment with diglyme.
Cheever
K L
KL
National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, Cincinnati, OH 45226.
Weigel
W W
WW
Richards
D E
DE
Lal
J B
JB
Plotnick
H B
HB
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005026:Ethylene Glycols / Q000008:administration & dosage / Q000633:toxicity*; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012671:Seminiferous Tubules / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology
D005026:Ethylene Glycols; D007527:Isoenzymes; D008738:Methyl Ethers; D007770:L-Lactate Dehydrogenase; C007391:diglyme