Isobolic determination of "ratio-linear" parameters in pharmacological stimulus-response models.
Two response models of fundamental importance in pharmacology are introduced, which are partly-specified functions of experimental variables, unknown parameters and random disturbances. An analysis is carried out of the extent of determination of the parameters from knowledge of isobol structure alone, with results that are more powerful than might have been expected. Moreover, such knowledge is exhaustive, unless untestable assumptions are admitted. The paper is not concerned with statistical methods for estimating the determined parameters.
Stone
M
M
Department of Statistical Science, University College, London, England.
D016014:Linear Models; D008433:Mathematics; D010600:Pharmacology; D011955:Receptors, Drug
D011955:Receptors, Drug