Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol.
The (-) enantiomer of gossypol but not the (+) enantiomer had good antiviral activity in peripheral blood mononuclear cells against human immunodeficiency virus type 1 at a concentration more than 20-fold lower than that required for cytotoxicity; however, in H9 cells the (-) enantiomer, although more potent as an antiviral agent, was more cytotoxic.
Lin
T S
TS
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510.
Schinazi
R
R
Griffith
B P
BP
August
E M
EM
Eriksson
B F
BF
Zheng
D K
DK
Huang
L A
LA
Prusoff
W H
WH
D002478:Cells, Cultured; D006072:Gossypol / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects; D013237:Stereoisomerism; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000494:pharmacology
D015215:Zidovudine; D006072:Gossypol