title: [Experimental chemotherapy of alveolar hydatid disease. 12. The efficacy of drug forms of mebendazole and nocodazole with high bioavailability].
abstract: New formulations have been designed to increase the efficacy and bioavailability of the oral drugs mebendazole and nocodazole and were tested in CBA mice. A considerable increase in efficacy was established for a solid disperse formulation of certain composition with a relatively lower toxicity than in aqueous suspensions of the drugs.
authors.forename: V I
authors.initials: VI
authors.lastname: Dzhabarova
authors.forename: A E
authors.initials: AE
authors.lastname: Dobrotvorskiĭ
authors.forename: A I
authors.initials: AI
authors.lastname: Krotov
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004353:Drug Evaluation, Preclinical; D004443:Echinococcosis / Q000188:drug therapy*; D007273:Injections, Intramuscular; D008463:Mebendazole / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D051379:Mice; D008808:Mice, Inbred CBA; D015739:Nocodazole / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D012995:Solubility; D013535:Suspensions
chemical_list: D013535:Suspensions; D008463:Mebendazole; D015739:Nocodazole
vernacular_title: Eksperimental'naia khimioterapiia al'veokokkoza. Soobshchenie 12. Effektivnost' lekarstvennykh form mebendazola i nokodazola s povyshennoĭ biostupnost'iu.