In-vitro activity of flomoxef, a new oxacephem group antibiotic, against Nocardia in comparison with other cephalosporins.
The susceptibility of 113 strains of pathogenic Nocardia, N. asteroides, N. farcinica, N. nova, N. brasiliensis and N. otitidiscaviarum to a new oxacephem antibiotic flomoxef was determined by an agar dilution method in comparison with those of 13 other cephalosporins. Flomoxef was two to 50 times more active against these pathogenic Nocardia than other cephalopsorins tested. However, there were differences in susceptibility to this antibiotic among these Nocardia strains. N. asteroides was the most sensitive species, followed by N. farcinica and N. nova. N. brasiliensis was moderately sensitive and N. otitidiscaviarum was resistant.
Yazawa
K
K
Department of Experimental Chemotherapy, Chiba University, Japan.
Mikami
Y
Y
Uno
J
J
Otozai
K
K
Arai
T
T
D002511:Cephalosporins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000187:drug effects*; D009617:Nocardia Infections / Q000382:microbiology
D002511:Cephalosporins; C045693:flomoxef