[Effects of various physiologic adenine derivatives on the secretion of acid in isolated gastric glands in rabbits].
The physiological adenine derivatives, adenosine (ADO), adenosine 5'-monophosphate (AMP), adenosine 5'-diphosphate (ADP) and adenosine 5'-triphosphate (ATP) at concentrations ranging from 10 microM to 1 mM caused concentration-related modifications on gastric H+ secretion, as measured by the aminopyrine accumulation method, in resting and histamine-stimulated rabbit gastric glands. In resting glands, ADO caused significant concentration-related increases of the basal H+ secretion, whereas no changes were obtained in response to the other purines tested. In histamine-stimulated glands, ADO and AMP caused concentration-related potentiation of the histamine-raised H+ secretory rate, while ATP and ADP induced graded inhibition. The results suggest the involvement of purinergic mechanisms in the physiological regulation of the gastric acid secretory process.
Ainz
L F
LF
Departamento de Fisiología, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao, España.
Gil-Rodrigo
C E
CE
Gómez
R
R
Malillos
M
M
Requejo
D
D
Gandarias
J M
JM
D000241:Adenosine / Q000502:physiology*; D000244:Adenosine Diphosphate / Q000502:physiology*; D000249:Adenosine Monophosphate / Q000502:physiology*; D000255:Adenosine Triphosphate / Q000502:physiology*; D000818:Animals; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D008297:Male; D011817:Rabbits
D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000241:Adenosine
Efecto de algunos derivados fisiológicos de la adenina sobre la secreción de ácido en glándulas gástricas aisladas de conejo.