title: [Fulminant hepatitis induced by disulfiram in a patient with alcoholic cirrhosis. Survival after liver transplantation].
abstract: Fulminant hepatitis was observed in a 44-year-old patient with cirrhosis, 38 days after the beginning of a treatment by disulfiram. Hepatitis was associated with fever and hypereosinophilia. Liver transplantation was performed with success. We reviewed 15 previously published cases of disulfiram-induced hepatitis. They occurred from 10 to 180 days after the beginning of the treatment by disulfiram, aminotransferases were increased whereas alkaline phosphatases were not markedly changed; there was either focal or widespread necrosis. Fulminant hepatitis was observed mainly in patients with alcoholic chronic liver disease or in patients who continued to ingest disulfiram while jaundice was already present. An immunoallergic mechanism is thought to be responsible for disulfiram-induced hepatitis.
authors.affiliation: Service de Réanimation et de Médecine d'Urgence, Centre Hospitalier Emile-Roux, Eaubonne.
authors.forename: D
authors.initials: D
authors.lastname: Vanjak
authors.forename: D
authors.initials: D
authors.lastname: Samuel
authors.forename: F
authors.initials: F
authors.lastname: Gosset
authors.forename: S
authors.initials: S
authors.lastname: Derrida
authors.forename: R
authors.initials: R
authors.lastname: Moreau
authors.forename: T
authors.initials: T
authors.lastname: Soupison
authors.forename: A
authors.initials: A
authors.lastname: Soulier
authors.forename: H
authors.initials: H
authors.lastname: Bismuth
authors.forename: C
authors.initials: C
authors.lastname: Sicot
mesh_terms: D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D004221:Disulfiram / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications* / Q000188:drug therapy; D016031:Liver Transplantation; D008297:Male
chemical_list: D004221:Disulfiram
vernacular_title: Hépatite fulminante au disulfirame chez un malade atteint de cirrhose alcoolique. Survie après transplantation hépatique.