Synthesis and antiviral evaluation of 6-p-ethylphenyl-5H-pyrrolo [3,4-b]pyridine-5,7-dione.
The synthesis of 6-(p-ethylphenyl)-5H-pyrrolo [3,4-b]pyridine-5,7-dione is described. The compound has been studied for its in vitro activity on RNA-containing influenza viruses types A and B. The preliminary results indicate that the compound has a significant antiviral activity against influenza viruses types A and B at concentrations at which no cytotoxic effects on MRC-5 cells in tissue culture are present.
Rashan
L J
LJ
Department of Biology, College of Education, University of Mosul, Iraq.
Ahmed
B A
BA
Hussein
S H
SH
al-Khayat
R
R
al-Omar
L
L
D000998:Antiviral Agents / Q000138:chemical synthesis*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D009980:Influenza A virus / Q000187:drug effects; D009981:Influenza B virus / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology
D000998:Antiviral Agents; D011725:Pyridines; D011760:Pyrrolidinones; C062381:6-(4-ethylphenyl)-5H-pyrrolo(3,4-b)pyridine-5,7-dione