Secretor state and renal scarring in girls with recurrent pyelonephritis.
The non-secretor phenotype was significantly associated with the occurrence of renal scarring among patients with recurrent pyelonephritis. Girls (n = 77) with recurrent pyelonephritis were followed from the first known episode of infection for up to twelve years with repeated radiological investigations. They were divided into two categories: those with renal scars (n = 35) and those who did not develop scars (n = 42). There was a significant over-representation of non-secretors among the patients with scarring, (14/35, 40%) compared to the healthy controls (21.8%, P less than 0.05). The frequency of non-secretors among the girls who did not develop scars in spite of repeated episodes of acute pyelonephritis was not significantly different from the healthy controls (9/42, 21% n.s.). This study provides a basis for analysis of the influence of secretor state on host-parasite interaction in the urinary tract.
Lomberg
H
H
Department of Clinical Immunology, University of Göteborg, Sweden.
Hellström
M
M
Jodal
U
U
Svanborg Eden
C
C
D000017:ABO Blood-Group System; D002648:Child; D002921:Cicatrix / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*; D010641:Phenotype; D011704:Pyelonephritis / Q000097:blood* / Q000150:complications; D012008:Recurrence; D012307:Risk Factors; D014718:Vesico-Ureteral Reflux / Q000150:complications
D000017:ABO Blood-Group System