title: Exploration of antileishmanial activity in heterocycles; results of their in vivo & in vitro bioevaluations.
abstract: A total of 51 imidazoles, pyrroles, quinolines and isoxazolines compounds were screened for antileishmanial activity in vivo and in vitro, using Leishmania donovani as the test parasite. The screening revealed hitherto unknown antileishmanial activity in these heterocycles. Three of the compounds screened (one belonging to isoxazoline series and two from pyrrole series) showed significant anti-leishmanial activity, ranging from 86-91 per cent inhibition in hamsters. When tested in vitro, using macrophage amastigote culture system, these compounds showed inhibition of 62-78 per cent at 30 micrograms/ml concentration.
authors.forename: S
authors.initials: S
authors.lastname: Bhatnagar
authors.forename: P Y
authors.initials: PY
authors.lastname: Guru
authors.forename: J C
authors.initials: JC
authors.lastname: Katiyar
authors.forename: R
authors.initials: R
authors.lastname: Srivastava
authors.forename: A
authors.initials: A
authors.lastname: Mukherjee
authors.forename: M S
authors.initials: MS
authors.lastname: Akhtar
authors.forename: M
authors.initials: M
authors.lastname: Seth
authors.forename: A P
authors.initials: AP
authors.lastname: Bhaduri
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006224:Cricetinae; D006571:Heterocyclic Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D007893:Leishmania donovani / Q000187:drug effects*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008297:Male
chemical_list: D000981:Antiprotozoal Agents; D006571:Heterocyclic Compounds