[Oral immunization against tetanus, using liposome-entrapped tetanus toxoid].
A study was made on oral immunization using a tetanus toxoid. Liposome entrapped tetanus toxoid (LTT) was p.o. administered to cats and serum antibody responses were examined. As a result it was known that the LTT antigen induced antibody production in the serum and that an antitoxin antibody titer higher than 0.1 IU/ml, a prophylactic level against tetanus, was produced. On the contrary to this, no antibody was detected in the group administered a tetanus toxoid alone throughout the test period. Also, when an absorbed tetanus toxoid (ATT) was booster-injected to cats p.o. primed with LTT, high responses of the secondary immunization were obtained. Moreover, in case LTT was p.o. administered as a booster antigen, the antitoxin titer in the serum showed a rapid, steep elevation. From these results it has been clarified that LTT on p.o. administration produces an antibody equivalent to the subcutaneous inoculation of ATT.
Hiraga
C
C
Ishii
F
F
Ichikawa
Y
Y
D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation; D002415:Cats; D004337:Drug Carriers; D007114:Immunization / Q000379:methods; D008081:Liposomes; D013742:Tetanus / Q000517:prevention & control*; D013743:Tetanus Antitoxin / Q000032:analysis; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000276:immunology
D004337:Drug Carriers; D008081:Liposomes; D013743:Tetanus Antitoxin; D013745:Tetanus Toxoid