title: In vitro thrombolysis of thrombosed valve prostheses: therapeutic considerations of left-sided thrombotic lesions.
abstract: Six thrombosed Bjørk-Shiley mitral valve prostheses which had been removed in emergency reoperations between November 1985 and December 1986 underwent in vitro thrombolysis with urokinase. After a mean period of 14 +/- 3 h of in vitro fibrinolysis, lysis of thrombus was observed, but large fragments of organized thrombus were released into the medium, suggesting that thrombolytic therapy should not be used for thrombotic occlusions on the left side of the heart, as the risk of systemic embolization is high.
authors.affiliation: Department of Cardiovascular Surgery, Higher Specialization Hospital of Turkey, Ankara.
authors.forename: H Y
authors.initials: HY
authors.lastname: Karagoz
authors.forename: K M
authors.initials: KM
authors.lastname: Babacan
authors.forename: Y I
authors.initials: YI
authors.lastname: Zorlutuna
authors.forename: O
authors.initials: O
authors.lastname: Tasdemir
authors.forename: C
authors.initials: C
authors.lastname: Yakut
authors.forename: K
authors.initials: K
authors.lastname: Bayazit
mesh_terms: D006350:Heart Valve Prosthesis; D006801:Humans; D066298:In Vitro Techniques; D008943:Mitral Valve; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy*; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology*
chemical_list: D014568:Urokinase-Type Plasminogen Activator