Turbinaric acid, a cytotoxic secosqualene carboxylic acid from the brown alga Turbinaria ornata.
A moderately cytotoxic secosqualene carboxylic acid designated turbinaric acid [1] has been isolated from the brown alga Turbinaria ornata, and it has been identified to be 4,8,13,17,21-pentamethyl-4,8,12,16,20-docosapentaenoic acid by means of spectral analysis and synthesis.
Asari
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F
Department of Chemistry, University of Tsukuba, Ibaraki, Japan.
Kusumi
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T
Kakisawa
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H
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D002264:Carboxylic Acids / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D056890:Eukaryota / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D000459:Phaeophyceae / Q000032:analysis*; D013185:Squalene / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002264:Carboxylic Acids; C062202:turbinaric acid; D013185:Squalene