Conformational characteristics of mixed sugar puckered deoxytetranucleoside triphosphate d-GpCpGpC from energy minimization studies.
As a continuation of our theoretical studies on nucleic acid subunit systems, in this article we consider the case of the tetranucleoside d-GpCpGpC, the minimally ideal representative unit for analyzing the relative stabilities of different forms of homo- and mixed helical conformation of polynucleotides. The four sugar rings are kept so as to generate B-genus, B+A genus and Z-genus conformations. Twenty five helical conformational states which resulted from judicious mixing of A-, B-, C-, W-, and Z-, states locally are subjected to energy minimization permitting the 19 dihedral angles to vary simultaneously. Conformational states corresponding to regular helical forms and mixed helical forms, when analyzed provide valuable information as to the local conformational flexibility and transitions available to polynucleotides.
Anukanth
A
A
School of Biological Sciences, Madurai Kamaraj University, Tamilnadu, India.
Ponnuswamy
P K
PK
D004247:DNA; D003855:Deoxyribose; D001330:Electronic Data Processing; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D009711:Nucleotides; D010710:Phosphates; D013816:Thermodynamics
D009711:Nucleotides; D010710:Phosphates; D003855:Deoxyribose; D004247:DNA