title: Differential effect of type I and type II diabetes mellitus on antipyrine elimination.
abstract: Antipyrine elimination was studied in 11 type I and 10 type II diabetic patients and 2 age-matched control groups. After oral administration of antipyrine (15 mg/kg), salivary concentration of the drug was measured at various time intervals by high performance liquid chromatography method. In type I diabetics the clearance rate (CL) and apparent volume of distribution (V) of the drug were significantly higher when compared to corresponding controls. The elimination half-life (t 1/2) remained unaltered. In type II diabetics, the t 1/2 of the drug was increased due to increase in V. There was no significant difference in CL. It is concluded that antipyrine elimination is enhanced in type I diabetics while in type II patients it is unaltered.
authors.affiliation: Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
authors.forename: C
authors.initials: C
authors.lastname: Adithan
authors.forename: D
authors.initials: D
authors.lastname: Danda
authors.forename: C H
authors.initials: CH
authors.lastname: Shashindran
authors.forename: J S
authors.initials: JS
authors.lastname: Bapna
authors.forename: R P
authors.initials: RP
authors.lastname: Swaminathan
authors.forename: S
authors.initials: S
authors.lastname: Chandrasekar
mesh_terms: D000293:Adolescent; D000328:Adult; D000983:Antipyrine / Q000493:pharmacokinetics*; D001786:Blood Glucose / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000378:metabolism
chemical_list: D000983:Antipyrine; D001786:Blood Glucose; D006442:Glycated Hemoglobin