title: Pefloxacin in the treatment of gram-negative infections in patients with hematologic diseases.
abstract: Quinolones are active against gram-negative strains. They are commonly used for selective intestinal decontamination in patients with hematologic malignancies and prolonged neutropenia due to chemotherapy. In our open study we used pefloxacin, a new fluoroquinolone, for the treatment of fifteen documented gram-negative infections in hematologic patients. Thirteen patients were mildly neutropenic, and in nine cases they received oral treatment as non-hospitalized patients. Cure was achieved in fourteen cases, with microbiological eradication of the offending pathogen.
authors.forename: A
authors.initials: A
authors.lastname: Micozzi
authors.forename: P
authors.initials: P
authors.lastname: Martino
authors.forename: R
authors.initials: R
authors.lastname: Raccah
authors.forename: C
authors.initials: C
authors.lastname: Girmenia
authors.forename: G
authors.initials: G
authors.lastname: Gentile
authors.forename: S
authors.initials: S
authors.lastname: Santilli
authors.forename: B
authors.initials: B
authors.lastname: Monarca
mesh_terms: D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006090:Gram-Negative Bacteria; D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D008297:Male; D015366:Pefloxacin / Q000627:therapeutic use*
chemical_list: D015366:Pefloxacin