[Combination effect of photodynamic therapy and microwave hyperthermia on experimental squamous cell carcinoma in vivo].
We investigated the time course of Hematoporphyrin oligomer (HpO) uptake to squamous cell carcinoma (SCC) transplanted into C3H mice after intraperitoneal (i.p.)-injection by measuring its fluorescence intensity. The fluorescence intensity was maximum at 83 hr after the i.p.-injection. The tumors once disappeared by the single application of photodynamic therapy (PDT) or microwave hyperthermia at 83 hr after HpO i.p.-injection. However, all the tumors treated with these single modalities recurred within 4 weeks after the treatments. Therefore, we investigated the therapeutic effect of microwave hyperthermia in combination with PDT at 83 hr after HpO i.p.-injection. As the results, the combination effect was the strongest when high-dose therapy was used as the first choice of therapy, irrespective of the orders of the treatments and no tumor regrowth occurred over 45 days after tumor disappearance.
Matsumoto
N
N
Saito
H
H
Miyoshi
N
N
Nakanishi
K
K
Fukuda
M
M
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D006414:Hematoporphyrin Photoradiation; D006415:Hematoporphyrins / Q000493:pharmacokinetics; D006979:Hyperthermia, Induced / Q000379:methods; D051379:Mice; D008809:Mice, Inbred C3H; D008872:Microwaves / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D010778:Photochemotherapy
D006415:Hematoporphyrins