Changes of blood flow in the adenohypophysis of normal and estrogen pretreated Fisher rats by tamoxifen.
Blood flow was measured in the adenohypophysis and in the cerebral cortex of female F344 rats over a period of 90 min using the hydrogen clearance method. Tamoxifen, 1 mg/kg, administered iv reduced the blood flow in the adenohypophysis by 35%, whereas cerebral blood flow and arterial pressure remained unchanged. Seven days sc treatment with tamoxifen (1 mg/kg daily) had no demonstrable effect on blood flow. Anterior pituitary hyperplasia was induced in 15 rats with diethylstilbestrol containing implants. These rats responded to 7 days of sc tamoxifen treatment by 30% increase in adenohypophyseal blood flow. These results suggest that tamoxifen has a different effect on adenohypophysial circulation of the rat depending on whether it is administered in a low- or high-estrogen state.
Stawowy
A
A
Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, England.
Kemeny
A A
AA
Jakubowski
J
J
D000818:Animals; D004054:Diethylstilbestrol / Q000008:administration & dosage*; D005260:Female; D006965:Hyperplasia; D007279:Injections, Subcutaneous; D010903:Pituitary Gland, Anterior / Q000098:blood supply* / Q000473:pathology; D051381:Rats; D011916:Rats, Inbred F344; D012039:Regional Blood Flow / Q000187:drug effects; D013629:Tamoxifen / Q000008:administration & dosage*
D013629:Tamoxifen; D004054:Diethylstilbestrol