Prediction of the virulencies of some enveloped viruses from the structure of the cleavage recognition site of viral glycoprotein essential for infectivity. II. Deviation analysis.
Analysis of the amino acid sequence in protein (deviation analysis) suggests that the binding between trypsin and the enveloped virus is the first step of their interaction, which occurs in a specified configuration. It is possible that the distance between their active sites is important for the viral sensitivity to trypsin, which is related to the virulency of the enveloped virus.
Kiho
Y
Y
Central Research Laboratory, Ishihara Sangyo kaisha, Ltd., Shigaken, Japan.
Miyata
K
K
Okada
Y
Y
D000595:Amino Acid Sequence; D001665:Binding Sites; D006023:Glycoproteins / Q000378:metabolism*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D012984:Software; D014357:Trypsin; D014764:Viral Proteins / Q000378:metabolism*; D014774:Virulence; D014780:Viruses / Q000378:metabolism / Q000472:pathogenicity*
D006023:Glycoproteins; D014764:Viral Proteins; D014357:Trypsin