[The selective toxicity of 5-hydroxymethyldeoxyuridine for the cells of human adenocarcinoma of the large intestine].
Comparing the toxicities of potential anticancer agents for tumorous and normal cells derived from human intestinal epithelium may be a preferred approach for in vitro testing of compounds directed against colon carcinoma. 5-Hydroxymethyldeoxyuridine, a thymidine analog, was preferentially cytotoxic for two lines of human colon adenocarcinoma cells compared to a cell line derived from normal human fetal intestine. Unlike deoxyuridine and deoxycytydine, thymidine protected HT-29 human adenocarcinoma against 5-hydroxymethyldeoxyuridine toxicity, suggesting that thymidilate synthetase is the probable target enzyme of this thymidine analog. 5-Hydroxymethyldeoxyuridine may hold promise as an agent with specific activity against human adenocarcinoma cells.
Lockshin
A
A
Meshcherikova
V V
VV
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000970:Antineoplastic Agents / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004622:Embryo, Mammalian; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D013936:Thymidine / Q000031:analogs & derivatives* / Q000633:toxicity; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology
D000970:Antineoplastic Agents; C018080:5-hydroxymethyl-2'-deoxyuridine; D013936:Thymidine
Selektivnaia toksichnost' 5-gidroksimetildezoksiuridina dlia kletok adenokartsinomy tolstoĭ kishki cheloveka.