title: [Effectiveness of new quarternary ammonium chloride compounds against selected bacteria and fungi. XXI. Synthesis of alkoxymethyl-3,4-dimethyl- pyridine and 1-ethyloxymethyl-3-alkylthiomethylimidazole chlorides].
abstract: Syntheses and antibacterial properties of alkoxymethyl-3,4-dimethylpyridinium chlorides and 1-ethyloxymethyl-3-alkylthiomethylimidazolium chlorides are described. Alkoxymetgyl-3,4-dimethylpyridinium chlorides were synthetized by reacting 3,4-dimethylpyridine with chloromethyl alkyl ethers, while 1-ethyloxymethyl-3-alkylthiomethylimidazolium chlorides were obtained in reactions of 1-ethyloxymethylimidazol with chloromethyl alkyl sulfides. Antibacterial properties of the obtained compounds were tested on 13 strains of bacteria and fungi. Strong bacteriostatic activity was found to be displayed by iminium chlorides with octyloxymethyl, decyloxymethyl, octylthiomethyl and decylthiomethyl groups.
authors.forename: J
authors.initials: J
authors.lastname: Pernak
authors.forename: J
authors.initials: J
authors.lastname: Krysiński
authors.forename: A
authors.initials: A
authors.lastname: Skrzypczak
authors.forename: L
authors.initials: L
authors.lastname: Michalak
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001419:Bacteria / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D004353:Drug Evaluation, Preclinical; D004352:Drug Resistance, Microbial; D005658:Fungi / Q000187:drug effects*; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D066298:In Vitro Techniques; D011719:Pyrazines / Q000138:chemical synthesis / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D007093:Imidazoles; D011719:Pyrazines; D011725:Pyridines
vernacular_title: Badania nad skutecznościa działania nowych czwartorzedowych chlorków amoniowych wobec wybranych szczepów bakterii i grzybów. XXI. Synteza chlorków alkoksymetylo-3,4-dimetylopirydyniowych i chlorków 1-etyloksymetylo-3-alkilotiometyloimidazoliowych.