Twenty-four-hour whole-body retention of 47Ca-chloride: an index of global bone metabolism in rat models.
The 24-h whole-body retention (24-h WBR) of 47Ca-chloride was measured over a 4-week period in three rat models verified by histologic study. In the osteomalacic and osteoporotic groups the 24-h WBR values were significantly lower and higher, respectively, than in the control group from the 2nd week. Quantitative assessment of bone radiographs by microdensitometry revealed significant osteopenia in these groups at the 4th week. The 24-h WBR values of 47Ca were found to differentiate the three rat models from the early stage of disease development.
Seto
H
H
Department of Radiological Science, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Ihara
F
F
Kakishita
M
M
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002122:Calcium Chloride / Q000378:metabolism*; D002132:Calcium Radioisotopes; D004195:Disease Models, Animal; D008297:Male; D010018:Osteomalacia / Q000378:metabolism*; D010024:Osteoporosis / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002132:Calcium Radioisotopes; D002122:Calcium Chloride