[Effect of oxytocin and naloxone on the plasma levels of corticosterone in the rat].
The effect of two doses of oxytocin (2 or 4 UI/kg i.p.) has been studied in the male Wistar rats, either preceded or not by a naloxone administration (10 mg/kg i.p.), on the response of the hypothalamus-pituitary-adrenal system, the latter being valued by changes produced in the plasmatic corticosterone levels. Oxytocin produced significant increases of the plasmatic corticosterone levels, this effect being stronger and longer lasting after the superior dose. Naloxone alone produced the same effect, but not as intense and stable as that of oxytocin. Pretreatment with naloxone modified the response of the hypothalamus-pituitary-adrenal system to oxytocin, producing partial blockade. The results suggest that the oxytocin action on the hypothalamus-pituitary-adrenal axis might be mediated by the endogenous opiates.
Montilla
P
P
Departamento de Bioquímica, Facultad de Medicina, Universidad de Córdoba, España.
Muñoz
J L
JL
Ríos
J E
JE
Muñoz
M C
MC
D000302:Adrenal Cortex / Q000378:metabolism; D000818:Animals; D003345:Corticosterone / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology*; D010913:Pituitary-Adrenal System / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012636:Secretory Rate / Q000187:drug effects; D013045:Species Specificity
D009270:Naloxone; D010121:Oxytocin; D003345:Corticosterone
Efecto de la oxitocina y la naloxona sobre los niveles plasmáticos de corticosterona en la rata.