title: An evolutionary link for developing mammalian lungs.
abstract: Lungs of the human infant and those of other mammals are filled with fluid immediately prior to birth. Studies of the ionic composition of this fluid indicate that active ionic transport processes occur in the epithelial cells of the potential airspaces. The purpose of this study was to see if these active ion pumps were present in developing species other than mammals thus providing a possible evolutionary link to mammals. A series of samples of lung liquid, amniotic fluid, and plasma were taken from embryonic marine turtles gathered from clutches incubating in the beach at Mon Repos, Queensland, Australia during the summer of 1986-87. The concentrations of sodium, potassium and chloride ions and protein measured in these liquids indicated that active pumping processes similar to that seen in the mammalian lung were present in the developing lungs of these marine reptiles and further, circumstantial evidence was gathered to suggest that this liquid was partially reabsorbed prior to hatching. The results support the notion that processes responsible for the normal development of the human lung and lungs of other mammals are also present in the hollow lungs of marine turtles. Thus there is an evolutionary counterpart controlling lung development in more ancient species. It may be possible to generalize this observation to the development of hollow lungs of other species.
authors.affiliation: National Parks and Wildlife Service, Queensland, Australia.
authors.forename: J E
authors.initials: JE
authors.lastname: Maloney
authors.forename: C
authors.initials: C
authors.lastname: Darian-Smith
authors.forename: B
authors.initials: B
authors.lastname: Russell
authors.forename: M
authors.initials: M
authors.lastname: Varghese
authors.forename: J
authors.initials: J
authors.lastname: Cooper
authors.forename: C J
authors.initials: CJ
authors.lastname: Limpus
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001693:Biological Transport, Active; D002118:Calcium / Q000493:pharmacokinetics; D008168:Lung / Q000196:embryology*; D008322:Mammals / Q000502:physiology; D011188:Potassium / Q000493:pharmacokinetics; D012964:Sodium / Q000493:pharmacokinetics; D014426:Turtles / Q000502:physiology*
chemical_list: D012964:Sodium; D011188:Potassium; D002118:Calcium