title: Effect of corticosterone on epididymal lipids in pubertal rat.
abstract: Serum corticosterone excess was induced by the administration of corticosterone acetate to adrenal intact rats. Different lipid classes were studied in unwashed and washed (epididymal sperm and fluid free) caput and cauda epididymides. The unwashed caput epididymidis registered a significant decrease in total lipid, cholesterol and phospholipid while total glyceride glycerol and its fractions were not altered after corticosterone treatment. Among phospholipid fractions phosphatidyl inositol, choline and ethanolamine showed a significant decrease. Unlike the unwashed caput epididymidis, the washed caput region recorded a marked increase in total lipid, glyceride glycerol and its fractions. However, total lipid in the washed cauda region significantly increased and the increase was mainly due to triacyl glycerol. Though the phospholipid fractions phosphatidyl choline and ethanolamine showed an increase, the total phospholipid was not altered significantly. Serum testosterone and prolactin registered a significant decrease while gonadotropins were unaltered. On the withdrawal of corticosterone treatment, all the lipid classes turned to normalcy along with serum testosterone and prolactin. It is concluded that corticosterone excess favours lipid accumulation in the sperm free epididymal tissue and its influence on epididymis is region specific and reversible.
authors.forename: K
authors.initials: K
authors.lastname: Balasubramanian
authors.forename: J
authors.initials: J
authors.lastname: Arunakaran
authors.forename: N
authors.initials: N
authors.lastname: Srinivasan
authors.forename: M M
authors.initials: MM
authors.lastname: Aruldhas
authors.forename: P
authors.initials: P
authors.lastname: Govindarajulu
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000502:physiology*; D004822:Epididymis / Q000378:metabolism*; D050356:Lipid Metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003345:Corticosterone