[Sensitivity of human lymphocytes to antiproliferative effects of glucocorticoids and effectiveness of reception].
The relation between the type of lymphocyte dexamethasone sensitivity in vitro of 9 healthy donors and their corticosteroid receptor characteristics was tested. It was found that in the high sensitivity group the effectiveness of corticosteroid reception (ratio of quantity of glucocorticoid receptors and constant of dissociation (Bm/Kd) was significantly higher than in the group of low sensitivity. Thus, genetically related parameters of binding of glucocorticoid hormones to its receptors play a great role in lymphocyte glucocorticoid sensitivity of inhibition of mitogen stimulation.
Kalashnikova
E A
EA
Pukhal'skiĭ
A L
AL
Liashko
V N
VN
D003907:Dexamethasone / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects*; D011965:Receptors, Glucocorticoid / Q000032:analysis*
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone
Chuvstvitel'nost' limfotsitov cheloveka k antiproliferativnomu deĭstviiu gliukokortikoidov i éffektivnost' retseptsii.