title: Synthesis and properties of oligodeoxyribonucleotides containing N6-methoxyadenine.
abstract: Oligodeoxyribonuclotides containing N6-methoxyadenine (mo6A), a promutagenic base, were synthesized. The Tm values and thermodynamic parameters for double strand formation of d(CCTGGTAmo6ACAGGTCC) have been measured. The order of the base-pair stability was A-T greater than mo6A-C approximately equal to mo6A-T greater than A-C.
authors.affiliation: Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nishino
authors.forename: A
authors.initials: A
authors.lastname: Ono
authors.forename: A
authors.initials: A
authors.lastname: Matsuda
authors.forename: T
authors.initials: T
authors.lastname: Ueda
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives*; D001483:Base Sequence; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D013816:Thermodynamics
chemical_list: D009838:Oligodeoxyribonucleotides; D000225:Adenine