title: Owl monkey gene map: evidence for a homologous human chromosome 7q region near the cystic fibrosis locus.
abstract: We have demonstrated the assignments of two gene loci (COLIA2, MET) and two noncoding DNA markers (D7S13, D7S8) to owl monkey chromosome 14 (K-VI) by hybridizing DNA probes from the cystic fibrosis (CF) region of human chromosome 7q21-32 to panels of rodent-owl monkey somatic cell hybrids. The assignments are substantiated by in situ chromosome hybridization of markers COLIA2, MET, and D7S13 to the distal long arm of chromosome 14 (K-VI). These results support genomic conservation of the human CF region, at least in the higher primates.
authors.affiliation: New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772.
authors.forename: N S
authors.initials: NS
authors.lastname: Ma
authors.forename: T S
authors.initials: TS
authors.lastname: Harris
authors.forename: P
authors.initials: P
authors.lastname: Watkins
authors.forename: L C
authors.initials: LC
authors.lastname: Tsui
mesh_terms: D000818:Animals; D001029:Aotus trivirgatus / Q000235:genetics*; D001483:Base Sequence; D015139:Blotting, Southern; D002427:Cebidae / Q000235:genetics*; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D003094:Collagen / Q000235:genetics*; D003550:Cystic Fibrosis / Q000235:genetics*; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D005260:Female; D015870:Gene Expression; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D011519:Proto-Oncogenes; D012689:Sequence Homology, Nucleic Acid
chemical_list: D015342:DNA Probes; D005819:Genetic Markers; D003094:Collagen; D004247:DNA