title: Platelet aggregability and in vivo platelet deposition in patients with ischemic cerebrovascular disease--evaluation by indium-111-platelet scintigraphy.
abstract: In ischemic cerebrovascular disease, it is not clear whether platelet function in vitro actually reflects the situation in vivo. Using indium-111 platelet scintigraphy as a method for detecting platelet activation in vivo, we tried to elucidate this problem. Twenty eight patients with chronic stage of ischemic cerebrovascular disease (CVD) and 17 control subjects were examined. Platelet scintigrams were positive in 9 of 28 patients in CVD, while all were negative in control. A comparison of the results obtained from qualitative platelet imaging and platelet aggregability was performed to evaluate whether threshold aggregation concentration (TAC) grade differed across the three groups (control, CVD patients without platelet deposition and CVD patients with platelet deposition). CVD patients with platelet deposition showed a higher TAC than those patients who did not show platelet deposition (P less than 0.05) or control subjects without platelet deposition (P less than 0.05). These results suggest that some patients in chronic stages of CVD may have active platelet deposition on carotid atheromatous lesions, and presence of platelet deposition in vivo could contribute to reduce platelet reactivity in peripheral blood.
authors.affiliation: Department of Cardiovascular Medicine, National Osaka Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Isaka
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: A
authors.initials: A
authors.lastname: Uehara
authors.forename: K
authors.initials: K
authors.lastname: Hashikawa
authors.forename: M
authors.initials: M
authors.lastname: Mieno
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: N
authors.initials: N
authors.lastname: Handa
authors.forename: S
authors.initials: S
authors.lastname: Nakabayashi
authors.forename: M
authors.initials: M
authors.lastname: Imaizumi
authors.forename: T
authors.initials: T
authors.lastname: Kamada
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000097:blood* / Q000000981:diagnostic imaging; D002561:Cerebrovascular Disorders / Q000097:blood; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D002546:Ischemic Attack, Transient / Q000097:blood; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D011877:Radionuclide Imaging
chemical_list: D007205:Indium Radioisotopes