The effect of D-penicillamine in the developing rat cerebellum.
The effect of D-penicillamine (DPA), a copper chelator, on the cerebellar maturation of the offspring of pregnant rats is evaluated. Pups of the mothers which received DPA in a daily dose of 300-400 mg during their last six days of gestation, showed an appreciable decrease in body and cerebellum weights, and cerebellar degenerative changes on histological examination. A postnatal diet DPA-free given to lactating mothers appeared to have a significant effect in reversing the cerebellar degenerative changes in their offspring.
Yurdakök
M
M
Topaloğlu
H
H
Haziroğlu
R
R
D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology; D002531:Cerebellum; D003300:Copper / Q000172:deficiency*; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced* / Q000473:pathology; D010396:Penicillamine / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats
D003300:Copper; D010396:Penicillamine