[Substantiation, tactics and effectiveness of frozen plasma-enzyme inhibitor therapy in septicemia and infectious-destructive processes].
Nonvalidated transfusions of fresh frozen plasma (with the aim of blood loss substitution, for parenteral feeding, etc.) are widely used in the current clinical practice. In disseminated intravascular coagulation syndrome (DICS) its use is undoubtedly indicated, but only by jet-injection, combined with low doses of heparin, and simultaneous administration of high doses of protease inhibitors (kontrikal, etc.); such treatment should be conducted at the early stages of the process, and not in the period of complete noncoagulation and profuse hemorrhage. The treatment was applied to 194 patients with sepsis and 147 patients with acute infectious-destructive diseases of the lungs; in 12 patients plasmapheresis was used simultaneously. More rapid, than in the compared group, arrest of fever and decrease of intoxication, recovery of microcirculation in the organs, increased accessibility of the infection foci for antibiotics, more than twofold reduction of lethality were recorded during this treatment. The data obtained have evidenced that infectious-septic DICS is an indication for cryoplasma-antienzyme therapy. Expenditure of fresh frozen plasma for many other purposes could be significantly diminished.
Barkagan
Z S
ZS
Shoĭkhet
Ia N
IaN
D000208:Acute Disease; D001424:Bacterial Infections / Q000097:blood* / Q000150:complications; D001803:Blood Transfusion / Q000379:methods*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000628:therapy*; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D010956:Plasmapheresis; D011480:Protease Inhibitors / Q000008:administration & dosage*; D018805:Sepsis / Q000097:blood* / Q000150:complications
D011480:Protease Inhibitors; D006493:Heparin
Obosnovanie, taktika primeneniia i éffektivnos't krioplazmenno- antifermentnoĭ terapii pri sepsise i infektsionno-destruktivnykh protsessakh.