title: [Ca2+-phospholipid-dependent phosphorylation of cytosol and membrane proteins of the brain in light craniocerebral trauma].
abstract: Immediately after light craniocerebral trauma (LCCT) the system of Ca2+, phospholipid-dependent phosphorylation of cytosol and microsomes of diencephalic-brainstem regions was impaired. The system of regulation of activity of C-kinase by phosphatidylserine was upset in the course of posttraumatic period and was different for cytosol and hemispheres. The increase in phosphorylation upon addition of exogenic C-kinase to incubation medium was evident only with stimulation of endogenic phosphorylation by phosphatidylserine. The decrease in Ca2+, phospholipid-dependent phosphorylation was characteristic of all fractions studied 1 day after trauma. After 14 days, the enzyme activity did not return to baseline. The authors suggest that C-kinase participates in trigger mechanisms of posttraumatic disease.
authors.forename: S N
authors.initials: SN
authors.lastname: Kucherenko
authors.forename: L I
authors.initials: LI
authors.lastname: Ostapchenko
authors.forename: A N
authors.initials: AN
authors.lastname: Vasil'ev
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000201:enzymology / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D010718:Phosphatidylserines / Q000378:metabolism; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*; D011817:Rabbits; D013997:Time Factors
chemical_list: D008565:Membrane Proteins; D010718:Phosphatidylserines; D011493:Protein Kinase C
vernacular_title: Ca2+-fosfolipidzavisimoe fosforilirovanie belkov tsitozolia i membran golovnogo mozga v dinamike legkoĭ cherepno-mozgovoĭ travmy.