Plasma levels of endotoxin and anaphylatoxin in patients with multiple organ failure.
Plasma concentrations of endotoxin and anaphylatoxins were studied inpatients with multiple organ failure (MOF). Thirty one blood samples from nine patients with MOF and twenty samples from preoperative patients as control were determined. The average plasma concentration of endotoxin was 188.7 +/- 37.0 pg-ml-1 (Mean + S.E.) in MOF patients and 12.4 +/- 3.3 pg.ml-1 in control patients (p less than 0.05). Plasma anaphylatoxin (C3a, C5a) levels increased significantly and C4 level decreased in MOF patients as compared with those in control patients. However, no significant correlation was found between plasma endotoxin and anaphylatoxin levels. Endotoxin does not seem to be a major factor in activating of the complement system in patients with MOF.
Tsubo
T
T
Ishihara
H
H
Sato
Y
Y
Kudo
M
M
Matsuki
A
A
Oyama
T
T
D000328:Adult; D000706:Anaphylatoxins / Q000032:analysis*; D003167:Complement Activation; D004731:Endotoxins / Q000097:blood*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008033:Limulus Test; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood*
D000706:Anaphylatoxins; D004731:Endotoxins; D007074:Immunoglobulin G