[A comparative analysis of the Salmonella typhi strains isolated from patients and bacterial carriers].
The comparative analysis of 133 S. typhi clinical strains isolated from patients and carriers in Dnepropetrovsk Province in 1978-1987 was carried out. As shown by this analysis, 10 Vi phage types were represented in the set of strains under study, phage types A and F1 being the most numerous ones. Phage type F1 occurred less frequently among the strains isolated from carriers. 31.1% of the strains were found to contain plasmids with different molecular weight ranging from 96 to 0.5 MD. The occurrence of plasmid-containing strains remained at the same level during the whole period under study. Low-molecular plasmids occurred more frequently in the strains isolated from carriers. The minimal suppressive concentrations of a number of antibiotics, such as penicillin, ampicillin, monomycin, chloramphenicol, tetracycline, rifampicin and streptomycin, were determined. 7% of the strains were resistant to penicillin, 9% to monomycin, 15%--to tetracycline and 2.6% to chloramphenicol. The correlation between penicillin and monomycin resistance of the strains and the presence of the plasmid with a molecular weight of 60 MD in these strains was established. All strains were shown to be highly variable in the degree of their virulence: from 10(2) to 10(8). The strains isolated from patients possessed greater virulence.
Riabchenko
L E
LE
Riapis
L A
LA
Sladkova
L M
LM
Vostrova
E I
EI
Kravtsov
Iu V
IuV
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000942:Antigens, Bacterial / Q000032:analysis; D001434:Bacteriophage Typing; D002353:Carrier State / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D006801:Humans; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D010957:Plasmids / Q000235:genetics; D012485:Salmonella typhi / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification* / Q000472:pathogenicity; D014435:Typhoid Fever / Q000382:microbiology*; D014455:Ukraine; D014774:Virulence
D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial
Sravnitel'nyĭ analiz shtammov Salmonella typhi, vydelennykh ot bol'nykh i bakterionositeleĭ.