title: [The immunization of adults against respiratory syncytial virus infection].
abstract: The results of the comparative study of the immunological effectiveness of experimental samples of respiratory syncytial (RS) viral vaccine, prepared from a live attenuated strain and introduced in a single administration to young adults by the intranasal, intradermal and combined intranasal-intradermal) routes, are presented. The effectiveness of intranasal immunization was inversely related to the level of previously existing humoral (serum, secretory) antibodies. Intradermal immunization enhanced the frequency of the formation of serum antibodies in persons having had such antibodies before the introduction of RS vaccine. The most active formation of serum and secretory antibodies was ensured by the combined (intranasal-intradermal) method of the administration of live RS vaccine which proved to be particularly effective in persons having had antibodies in the blood and secretions prior to immunization.
authors.forename: N P
authors.initials: NP
authors.lastname: Leshchinskaia
authors.forename: N L
authors.initials: NL
authors.lastname: Korchanova
authors.forename: E E
authors.initials: EE
authors.lastname: Pokrovskaia
authors.forename: B V
authors.initials: BV
authors.lastname: Efremov
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Padalko
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000918:Antibody Specificity / Q000276:immunology; D006801:Humans; D007114:Immunization / Q000379:methods*; D007277:Injections, Jet; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D010253:Respirovirus Infections / Q000276:immunology / Q000517:prevention & control*; D013997:Time Factors; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines
vernacular_title: Immunizatsiia vzroslykh protiv respiratorno-sintsitial'noĭ virusnoĭ infektsii.