title: In vivo evaluation of hydrophobic and fibrillar microporous polyetherurethane urea graft.
abstract: Mitrathane hydrophobic and fibrillar microporous prosthesis was implanted as infrarenal arterial substitute in dogs; it was evaluated in terms of patency rates, healing characteristics and biostability. Segments of grafts were implanted in duplicate for a period of implantation of 24 h, 1 wk, 1 month and 6 month. Two control grafts from the Ontario Research Foundation were implanted: one for 1 month, the other for six month. All except the two Mitrathane grafts implanted for 6 month were patent at death. The Mitrathane grafts showed kinking at one and 6 month post-implantation. The ORF graft implanted for 1 month was found crinkled in its mid-section and the external capsule was ruptured in the graft implanted for 6 month, without crinkling. Histological studies showed fibrin deposits on the flow surface and infiltration of blood elements into the wall of the Mitrathane grafts implanted for 24 h and 1 wk. A thin internal capsule was present on the graft flow surface of both types of graft tested 1 month post-implantation; scanning electron microscopy revealed the presence of endothelial-like cells on the luminal surface, particularly in the vicinity of the anastomoses. At 6 month, the Mitrathane grafts were occluded by a thick thrombus originating from the anastomoses, while the ORF graft showed infiltration of collagen through the polyurethane fibrillar structure of the wall with an endothelial-like lining covering the flow surface in the vicinity of both anastomoses.
authors.affiliation: Biomaterials Unit, St-François d'Assise Hospital, Quebec, Canada.
authors.forename: Y
authors.initials: Y
authors.lastname: Marois
authors.forename: R
authors.initials: R
authors.lastname: Guidoin
authors.forename: D
authors.initials: D
authors.lastname: Boyer
authors.forename: F
authors.initials: F
authors.lastname: Assayed
authors.forename: C J
authors.initials: CJ
authors.lastname: Doillon
authors.forename: R
authors.initials: R
authors.lastname: Paynter
authors.forename: M
authors.initials: M
authors.lastname: Marois
mesh_terms: D000818:Animals; D001011:Aorta / Q000601:surgery; D001672:Biocompatible Materials; D001773:Blood Cells / Q000473:pathology; D001807:Blood Vessel Prosthesis; D004285:Dogs; D005260:Female; D006083:Graft Occlusion, Vascular / Q000473:pathology; D008297:Male; D008855:Microscopy, Electron, Scanning; D011108:Polymers; D011140:Polyurethanes; D011474:Prosthesis Design; D013499:Surface Properties; D013927:Thrombosis / Q000473:pathology; D014654:Vascular Patency
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D011140:Polyurethanes; C044690:polyetherurethane urea