[Use of vincristine-loaded blood platelets, danazol and gamma globulin in the treatment of patients with idiopathic thrombocytopenic purpura].
In 17 patients with idiopathic thrombocytopenic purpura unresponsive to treatment with steroids, immunosuppression or splenectomy, allogenic vincristine-loaded platelets were used. In 9 of them an increase of platelet number and regression of bleeding tendency was achieved. Among 13 patients with ITP who have been treated with danazol only in one case an increase of platelet number was observed. Under the rise of plasma transaminases and bilirubin level in majority of "danazol" patients we have discontinued the treatment. In none of 4 patients with chronic thrombocytopenic purpura treated with high doses of intravenous immunoglobulin an increase of platelet number was observed, however in all cases the regression of bleeding was achieved.
Górski
J
J
Czestochowska
E
E
Tymiński
W
W
Kicińska
M
M
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects; D001803:Blood Transfusion; D003613:Danazol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion; D011245:Pregnadienes / Q000627:therapeutic use*; D011696:Purpura, Thrombocytopenic / Q000628:therapy*; D012074:Remission Induction; D014750:Vincristine / Q000008:administration & dosage / Q000097:blood*
D011245:Pregnadienes; D014750:Vincristine; D003613:Danazol
Zastosowanie płytek krwi obładowanych winkrystyna, danazolu i gammaglobuliny w terapli chorych z samoistna plamica małopłytkowa.