title: Echo-Doppler assessment of left ventricular filling in borderline hypertension.
abstract: The aim of this study was to evaluate left ventricular anatomy and diastolic function in borderline essential hypertension. To this aim, 16 borderline hypertensive patients underwent echocardiographic and pulsed-wave Doppler evaluation. As control groups, 20 normotensive controls and 20 patients with established hypertension were evaluated by the same procedure. By the Doppler assessment of transmitral blood flow, the following indices of left ventricular diastolic function were obtained: early (E) and late (A) peak flow velocity, late to early velocity ratio (A/E), early filling fraction (EFF) and acceleration and deceleration times of early and late flow peaks. Borderline hypertensives had an interventricular septum and posterior wall thickness significantly higher than normotensives and lower than established hypertensives. As regards the diastolic indexes, borderline hypertensive patients had significantly higher A peaks (P less than .02) and A/E ratios (P = .05) and lower EFF (P less than .02) as compared to normotensive controls. No significant differences were on the other hand observed with established hypertensive patients. This resultant diastolic pattern was independent of age, as indicated by the analysis of age-matched subgroups. The presence of diastolic function changes in borderline hypertension confirms the early appearance of this kind of abnormality in hypertensive heart disease. On the other hand, the finding of increased left ventricular wall thickness in borderline hypertensives does not allow us to conclude that, as suggested by other authors, diastolic function changes in the early stage of hypertension are independent on anatomical modifications.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: C.N.R. Institute of Clinical Physiology, Pisa, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Marabotti
authors.forename: A
authors.initials: A
authors.lastname: Genovesi-Ebert
authors.forename: C
authors.initials: C
authors.lastname: Palombo
authors.forename: S
authors.initials: S
authors.lastname: Giaconi
authors.forename: C
authors.initials: C
authors.lastname: Michelassi
authors.forename: S
authors.initials: S
authors.lastname: Ghione
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003326:Coronary Circulation; D003971:Diastole; D016002:Discriminant Analysis; D004452:Echocardiography; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles; D006801:Humans; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology*; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D012016:Reference Values