[Monoclonal antibodies. Their usefulness in the diagnosis of malignant tumors of the digestive system].
Lately, there is a lot of interest in tumor markers, monoclonal antibodies and immunoscanning in the diagnosis and follow-up of certain cancers. The main objective of this study is to report our initial experience with the detection of specific antibodies and with the obtention of scan images. In 85.7% of patients with cancer and in 40% of patients with benign conditions, above normal values of CEA were obtained. In 85.7% of patients with cancer and in 60% of patients with benign disease, above normal values of CA 19-9 were noted. Positive scans were obtained in 83.4% of cancer patients and 13.3% negative scans; it was not useful in one case. In benign conditions 40% of the scans were positive and 60% negative. I-131 was capable of detecting tumors very clearly. The statistical analysis employed was the exact test of Fisher and the correlation was evaluated with contingency coefficients.
Campos Campos
F
F
Romero Navarro
M A
MA
Gutiérrez Samperio
C
C
Esquivel
P
P
Gaviño Chapa
J F
JF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D004067:Digestive System Neoplasms / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000032:analysis; D008297:Male; D008875:Middle Aged
D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen; D007457:Iodine Radioisotopes
Anticuerpos monoclonales. Su utilidad en el diagnóstico de tumores malignos del aparato digestivo.