[Detection of latent spontaneous pathology of the central nervous system and visceral organs in rabbits by determining antibodies to tissue antigens and by a test for delayed hypersensitivity].
Complex immunological, pathologicoanatomic and histopathological examination of intact rabbits revealed a correlation between the appearance of complement fixation antibodies and delayed hypersensitivity to tissue antigens on the one hand and the development of spontaneous pathology of the corresponding organs on the other. Meningoencephalitis was diagnosed in all sick animals by means of immunological tests. Tests for antibodies and delayed hypersensitivity to tissue antigens revealed intracapillary glomerulonephritis, coccidiosis of the liver, and pneumonia. The authors recommend conduction of immunological tests for detecting latent spontaneous pathology in laboratory animals.
Kulikova
O S
OS
Magaeva
S V
SV
Martynenko
A V
AV
Martynenko
M V
MV
D000818:Animals; D000830:Animals, Laboratory; D000906:Antibodies / Q000032:analysis*; D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000473:pathology / Q000662:veterinary; D006968:Hypersensitivity, Delayed / Q000175:diagnosis* / Q000473:pathology / Q000662:veterinary; D007159:Immunologic Tests / Q000662:veterinary; D007674:Kidney Diseases / Q000175:diagnosis* / Q000473:pathology / Q000662:veterinary; D008107:Liver Diseases / Q000175:diagnosis* / Q000473:pathology / Q000662:veterinary; D008171:Lung Diseases / Q000175:diagnosis* / Q000473:pathology / Q000662:veterinary; D008297:Male; D011817:Rabbits
D000906:Antibodies
Vyiavlenie skrytoĭ spontannoĭ patologii tsentral'noĭ nervnoĭ sistemy i vistseral'nykh organov u krolikov pri pomoshchi opredeleniia antitel k tkanevym antigenam i testa na giperchuvstvitel'nost' zamedlennogo tipa.