Nitrile-induced behavioral abnormalities in mice.
A single oral dose of crotononitrile or 2-pentenenitrile induced behavioral abnormalities such as circling, hyperactivity and head twitching. Crotononitrile induced the abnormalities in both olive oil- and CCl4 pretreated mice, whereas 2-pentenenitrile induced the abnormalities only in CCl4-pretreated mice. Seven related compounds induced no behavioral abnormality. The head twitching by crotononitrile and 2-pentenenitrile was either reduced by treatment with serotonin and dopamine antagonists, or enhanced by a serotonin releaser, suggesting that both the serotonin and dopamine systems are involved in the behavioral abnormalities induced by these two nitriles.
Tanii
H
H
Department of Hygiene, School of Medicine, Kanazawa University, Japan.
Hayashi
M
M
Hashimoto
K
K
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002251:Carbon Tetrachloride / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology; D004347:Drug Interactions; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009570:Nitriles / Q000633:toxicity*; D011619:Psychotropic Drugs / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology
D009570:Nitriles; D011619:Psychotropic Drugs; C062712:2-pentenenitrile; D012701:Serotonin; C031103:crotononitrile; C015660:allyl cyanide; D002251:Carbon Tetrachloride; D004298:Dopamine