Ethnopharmacologic investigation of ginger (Zingiber officinale).
An ethanolic extract of the rhizomes of Zingiber officinale was investigated for anti-inflammatory, analgesic, antipyretic, antimicrobial and hypoglycaemic activities. In rats, the extract reduced carrageenan-induced paw swelling and yeast-induced fever but was ineffective in suppressing the writhing induced by intraperitoneal acetic acid. The extract produced blood glucose lowering in rabbits. The growth of both Gram-positive and Gram-negative bacteria was significantly inhibited. A dose-dependent inhibition of prostaglandin release effect was observed using rat peritoneal leucocytes.
Mascolo
N
N
Department of Experimental Pharmacology, University of Naples, Italy.
Jain
R
R
Jain
S C
SC
Capasso
F
F
D000700:Analgesics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001419:Bacteria / Q000187:drug effects; D007004:Hypoglycemic Agents; D066298:In Vitro Techniques; D007194:India; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity; D010946:Plants, Medicinal / Q000032:analysis*; D011453:Prostaglandins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D011453:Prostaglandins