[Local irritation study of miporamicin in male rabbits].
Local irritation effect of miporamicin (MPM), a new macrolide antibiotics for animal use, on skin and ocular tissues was determined in rabbits by the primary skin irritation test and ocular irritation test, respectively. In the former test, P.I.I. and inflammatory findings increased with increasing exposure time to MPM. A short-time contact with MPM caused relatively little effect on ocular tissues. Contrarily, a long-time contact with MPM caused medium or high degree of inflammatory reactions on cornea, iris and conjunctiva tissues. The increased inflammation was naturally accompanied with increases of the DRAIZE score. All these results suggest that MPM per se has local irritation effect on both skin and ocular tissues.
Kohira
T
T
Toxicological Research Laboratories, Research Center, Toyo Jozo Co., Ltd.
Nakanishi
D
D
Goto
I
I
Kobayashi
Y
Y
Matsumoto
K
K
Yamamoto
H
H
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D003228:Conjunctiva / Q000187:drug effects; D003315:Cornea / Q000187:drug effects; D007498:Iris / Q000187:drug effects; D007509:Irritants; D018942:Macrolides; D008297:Male; D011817:Rabbits; D012867:Skin / Q000187:drug effects
D000900:Anti-Bacterial Agents; D007509:Irritants; D018942:Macrolides; C063027:mirosamicin