title: [Bone metabolism in thalassemic children with multiple transfusions. Compartmental analysis of 99mTc-Sn-MDP kinetics].
abstract: The kinetics of 99mTc(Sn) methylene diphosphonate [99mTc(Sn)MDP] were evaluated by means of compartmental analysis in 5 normal children and 17 thalassemic subjects. Blood and urine activity were analyzed with a computer program which generates intercompartmental rate constants by an iterative least-square method providing a best-fit to the input data. The amount of tracer in each compartment (corrected for decay) was determined as a function of time. The transfer rate of 99mTc(Sn)MDP from blood to extracellular fluid and lamellar bone (K1-3) was about 20% higher in thalassemic subjects than in normal children. The transfer rate of 99mTc(Sn)MDP from blood to woven bone (K1-4) was about 57% higher in thalassemic subjects. A faster rate of spread into woven bone appears to be the major cause of higher bone uptake of 99mTc(Sn)MDP in thalassemic subjects, which suggests that in these patients bone tissue reoccupies the space previously replaced by hyperplastic marrow. Moreover, the increased bone extraction rate revealed a correlation between anemia and bone metabolic activity.
authors.affiliation: Centro Interdipartimentale di Biocibernetica e Tecniche Radioisotopiche, Università, Bari.
authors.forename: M
authors.initials: M
authors.lastname: Mele
authors.forename: D
authors.initials: D
authors.lastname: De Mattia
authors.forename: A
authors.initials: A
authors.lastname: D'Addabbo
authors.forename: F
authors.initials: F
authors.lastname: Schettini
authors.forename: F
authors.initials: F
authors.lastname: Lauriero
authors.forename: G
authors.initials: G
authors.lastname: Rubini
mesh_terms: D000293:Adolescent; D001803:Blood Transfusion; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D002648:Child; D006801:Humans; D007091:Image Processing, Computer-Assisted; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics*; D013789:Thalassemia / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000628:therapy
chemical_list: C023568:technetium Tc 99m (Sn)methylenediphosphonate; D013669:Technetium Tc 99m Medronate
vernacular_title: Metabolismo dell'osso in bambini talassemici politrasfusi. Analisi compartimentale della cinetica del 99mTc(Sn)MDP.