Effects of testosterone on morphology and on progestin and estrogen receptor levels in the mouse uterus and mammary gland.
The effects of androgen on the morphology and levels of cytosolic estrogen and progestin receptors (ER and PR) were studied in the mouse uterus and mammary gland. Testosterone neonatally and/or continuously in the adult lowers ER and PR levels particularly at early ages (40-60 days of age) in both the uterus and mammary gland. At older ages, less prominent changes in ER and PR levels are observed. Neonatal androgen treatment appears to exert both direct effects on the uterus and mammary gland and indirect effects (via the hypothalamo-hypophysio-ovarian axis). At all ages, neonatal testosterone in combination with continuous adult testosterone consistently depressed PR levels in both uterus and mammary gland, indicating that testosterone is a negative modulator of PR in these tissues.
Edery
M
M
Laboratoire de Physiologie de la Lactation, INRA, Jouy-en-Josas, France.
Mills
K T
KT
Bern
H A
HA
D000818:Animals; D005260:Female; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D011960:Receptors, Estrogen / Q000187:drug effects* / Q000378:metabolism; D011980:Receptors, Progesterone / Q000187:drug effects* / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D013739:Testosterone