[Prophylaxis of vitamin D deficiency in hypothyroidism in the newborn infant].
This study deals with the relationship between the occurrence of hypercalcemia and the administration of prophylactic doses of vitamin D in children with hypothyroidism, before and during L-thyroxine (LT4) treatment. The goal of the study was to determine the dosage of vitamin D necessary to prevent rickets without inducing hypercalcemia. There was a 23% prevalence of hypercalcemia at the time of the diagnosis of hypothyroidism by screening whereas it was 21% in the children who were not given vitamin D during the first 3 months of LT4 treatment. This figure was significantly higher in those who were given vitamin D during the first 3 months of treatment and reached 70%. However, one of the 19 children not given vitamin D presented with biological signs evoking vitamin D deficiency. In conclusion, in hypothyroid infants, vitamin D should be administered carefully during the first 6 months of treatment and restricted to children at risk for developing vitamin D deficiency.
Leger
J
J
Service d'Endocrinologie Pédiatrique et Diabète, Hôpital Robert-Debré, Paris.
Tau
C
C
Garabedian
M
M
Farriaux
J P
JP
Czernichow
P
P
D002112:Calcifediol / Q000097:blood; D004334:Drug Administration Schedule; D006801:Humans; D006934:Hypercalcemia / Q000139:chemically induced / Q000517:prevention & control; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D007231:Infant, Newborn; D013974:Thyroxine / Q000627:therapeutic use; D014807:Vitamin D / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000517:prevention & control*
D014807:Vitamin D; D002112:Calcifediol; D013974:Thyroxine
Prophylaxie de la carence en vitamine D chez le nouveau-né hypothyroïdien.