Adverse interaction between cimetidine and chlorpromazine in two cases of chronic schizophrenia.
The treatment of two chlorpromazine-medicated chronic schizophrenics with cimetidine resulted in excessive sedation, which necessitated a reduction in chlorpromazine dosage. Eventual discontinuation of cimetidine therapy led to a return of schizophrenic symptoms, which responded to an increase in chlorpromazine dosage to previous levels.
Byrne
A
A
Newcastle Hospital, Greystones, Co., Wicklow, Eire.
O'Shea
B
B
D002746:Chlorpromazine / Q000009:adverse effects*; D002927:Cimetidine / Q000009:adverse effects*; D004347:Drug Interactions; D004942:Esophagitis, Peptic / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy; D012559:Schizophrenia / Q000188:drug therapy*
D002927:Cimetidine; D002746:Chlorpromazine