title: Central lesion abolishes the beneficial effect of hypertonic saline on circulatory shock produced by compound 48/80 in rats.
abstract: The purpose of the present study was to examine the protective action of a 7.5% hypertonic NaCl solution (HS) on the circulatory shock produced by compound 48/80 (48/80) in rats and to determine the effect of the AV3V lesion on the protective action of HS. Intravenous injection of 48/80 into sham-operated rats resulted in an immediate drop of mean arterial pressure (MAP). In sham-operated rats, intravenous injection of HS prevented the drop of MAP produced by 48/80, but HS was ineffective in AV3V-lesioned rats. These results show that HS had a protective action on the circulatory shock produced by 48/80 and that the AV3V region plays an important role in this protective action.
authors.affiliation: Laboratório de Farmacologia, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Araraquara, Brasil.
authors.forename: C M
authors.initials: CM
authors.lastname: Giraldelo
authors.forename: E
authors.initials: E
authors.lastname: Colombari
authors.forename: J V
authors.initials: JV
authors.lastname: Menani
authors.forename: J F
authors.initials: JF
authors.lastname: Fracasso
mesh_terms: D000818:Animals; D002552:Cerebral Ventricles / Q000601:surgery; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012769:Shock / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
chemical_list: D012462:Saline Solution, Hypertonic; D003189:p-Methoxy-N-methylphenethylamine