Immunological profile in neonatal hyperbilirubinemia.
Thirty cases of neonatal hyperbilirubinemia of varying etiology, severity and duration; and twenty six normal healthy newborns were subjected to various tests of cellular and humoral immunity. The results revealed a significant depression of all the parameters of cellular immunity in neonatal hyperbilirubinemia of greater than or equal to 10 mg/dl as compared to the control values. The depression of immunological profile in these newborns was seen to be more pronounced with increasing duration and severity of jaundice. A limited assessment of the humoral immunity by the B cell count and serum immunoglobulin IgG levels, however, showed no significant difference from the control.
Sethi
R K
RK
Mishra
P K
PK
Sethi
A
A
Saxena
K P
KP
Kumar
R
R
D001402:B-Lymphocytes / Q000276:immunology; D003906:Developing Countries; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007194:India; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000276:immunology*; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology