[Effect of carbohydrate components of ristomycin A on platelet aggregation in human plasma].
In the process of the investigation, conditions for specific removal of arabinose in tetrasaccharide of ristomycin A, a glycopeptide antibiotic as well as conditions for simultaneous removal of arabinose and mannose-2 bound to actinoidinic acid were determined. The role of arabinose in manifestation of the ristomycin A ability to induce platelet aggregation was shown to be important. Mannose-2 also had the same ability while its level was somewhat lower.
Trifonova
Zh P
ZhP
Sturman
N V
NV
Zheltova
A O
AO
Katrukha
G S
GS
D001089:Arabinose / Q000032:analysis / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D003029:Coagulants; D006801:Humans; D066298:In Vitro Techniques; D008358:Mannose / Q000032:analysis / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D012310:Ristocetin / Q000032:analysis / Q000494:pharmacology*
D003029:Coagulants; D012310:Ristocetin; C016719:ristocetin A; D001089:Arabinose; D008358:Mannose
Vliianie uglevodnogo sostava ristomitsina A na agregatsiiu trombotsitov plazmy krovi cheloveka.