[Products of lipid peroxidation in the blood and respiratory secretions in 3 patients with acute respiratory diseases].
Oxygen free radicals have been suggested to be involved in ARDS pathogenesis. Their production may be caused by leukocyte activation and by administration of high oxygen concentrations. Radicals can oxidize lipids with production of dienes. In order to gather an indirect proof of radical production, dienes were repeatedly assessed in plasma and bronchoalveolar lavage (BAL) samples from three patients affected by ARDS. Plasma levels resulted higher than normal ones in all the patients initially; concentrations in BAL samples were lower than in plasma. Successively dienes decreased progressively in the patient who survived, whereas an increase was observed in BAL samples from the other patients, who died. The last trend was accompanied by a smaller increase in plasma levels.
Cavaliere
F
F
Clemente
A
A
Vagnoni
S
S
Carducci
P
P
Aureli
V
V
Lippa
S
S
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis*; D005260:Female; D005609:Free Radicals; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism; D012128:Respiratory Distress Syndrome / Q000097:blood* / Q000378:metabolism
D005609:Free Radicals; D010100:Oxygen
Prodotti della perossidazione lipidica nel plasma e nelle secrezioni respiratorie di tre pazienti affetti da ARDS.