Carbon tetrachloride-induced experimental cirrhosis in the rat: a reappraisal of the model.
The goal of this study was to evaluate the presence of extrahepatic damage and the uniformity and reversibility of the histological findings in CCl4-induced liver cirrhosis in the rat. To verify these findings rats were sacrificed 2 and 10 weeks after a treatment consisting of ten intragastric doses of CCl4, administered weekly. All treated rats developed an irreversible micronodular cirrhosis with no damage to the brain, kidney and pancreas. Moreover, rats sacrificed 2 weeks after the last CCl4 dose showed a number of functional alterations usually observed in man. In particular, low branched chain/aromatic amino acids (BCAA/AAA) plasma ratio, high ammonia, low zinc and high insulin with normal blood glucose were obtained.
Ariosto
F
F
II Cattedra di Gastroenterologia, Università di Roma La Sapienza, Italy.
Riggio
O
O
Cantafora
A
A
Colucci
S
S
Gaudio
E
E
Mechelli
C
C
Merli
M
M
Seri
S
S
Capocaccia
L
L
D000596:Amino Acids / Q000097:blood / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D002251:Carbon Tetrachloride; D008099:Liver / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D008115:Liver Regeneration; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000596:Amino Acids; D002251:Carbon Tetrachloride