[Radiation pathomorphosis of malignant melanoma of the uveal tract of the human eye].
The paper describes peculiarities of changes in uveal melanomas after beta application. It is shown that the degree of changes depends on the intensity of action, the cellular type of the tumor and the degree of its pigmentation. The most radiosensitive proved to be spindle cell B, mixed and epithelioid melanomas. Less radiosensitive are pigmented tumourous cells. The most intensive postradiation changes, were characterized by development of long-term existence of coagulation necrosis, growing of cellular polymorphism, hyperploidy, polynucleosis, appearance of apoptosis. The study of the reaction of monolayer culture of uveal melanomas on beta application has confirmed different radiosensitivity of melanoma cells of a different kind as well as has revealed that the growing of cellular polymorphism is a morphologic manifestation of a postradiation degeneration. The degree of postradiation changes correlated with the duration of monolayer culture of the tumor.
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D001610:Beta Particles / Q000627:therapeutic use; D006801:Humans; D008545:Melanoma / Q000473:pathology* / Q000532:radiotherapy; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000473:pathology / Q000528:radiation effects; D014602:Uvea / Q000473:pathology / Q000528:radiation effects; D014604:Uveal Neoplasms / Q000473:pathology* / Q000532:radiotherapy
Luchevoĭ patomorfoz zlokachestvennykh melanom uveal'nogo trakta glaza cheloveka.