A mathematical simulation of the AIDS patient and extracorporeal detoxification.
A simple numerical simulation of AIDS patient detoxification by a hypothetical extracorporeal device for the removal of viruses, infected white cells, and syncytia has been designed. The mathematical model accounts for healthy blood white cells attacking and destroying the viruses, while at the same time the viruses attack and infect certain white cells. The infected white cells serve as a site for viral growth; eventually the cells lyse, releasing a large number of viruses into the blood stream. The healthy white cells and infected white cells combine to form syncytia, where the virus multiplies, and finally the syncytium ruptures releasing all the virus. This model can be used to predict concentrations over a specified period for the patient. This is a mathematical model to be used as a research and design tool only.
Kapadvanjwala
M
M
Biotechnology Laboratory, New Jersey Institute of Technology, Newark 07102.
Sofer
S S
SS
D000386:AIDS-Related Complex / Q000382:microbiology; D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D002470:Cell Survival; D003198:Computer Simulation; D015726:Giant Cells / Q000382:microbiology; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology; D008954:Models, Biological; D014462:Ultrafiltration; D014779:Virus Replication