Acute effect of Russell's viper (Vipera russelli siamensis) venom on renal hemodynamics and autoregulation of blood flow in dogs.
Renal hemodynamics and autoregulation of blood flow were investigated following intravenous injection of Russell's viper venom (0.1 mg/kg) in dogs anesthetized with sodium pentobarbital. After venom injection, the glomerular filtration rate fell significantly throughout the experimental period of three hr. Urine flow rate and renal blood flow also decreased and the filtered load of electrolytes declined significantly. The fractional excretion of sodium, potassium and phosphorus increased following venom administration. These data suggest that the venom may depress both glomerular and tubular functions. The renal autoregulation of blood flow was maintained during the experimental reduction of renal arterial pressure. We conclude that the ability of renal vasculature to autoregulate renal blood flow is not inhibited by Russell's viper venom, even though renal function is depressed.
Sanguanrungsirikul
S
S
Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chomdej
B
B
Suwanprasert
K
K
Wattanavaha
P
P
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001806:Blood Urea Nitrogen; D004285:Dogs; D004573:Electrolytes / Q000652:urine; D005919:Glomerular Filtration Rate / Q000187:drug effects; D008297:Male; D012079:Renal Circulation / Q000187:drug effects*; D014563:Urodynamics / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D014757:Viper Venoms / Q000494:pharmacology*
D004573:Electrolytes; D014757:Viper Venoms