title: A case of normotensive primary aldosteronism with hypopituitarism, epilepsy, and medullary sponge kidney.
abstract: A 55-year-old man with normotensive primary aldosteronism, hypopituitarism, epilepsy, and medullary sponge kidney is reported. Seventeen years before admission, he had been noted to have hypokalemia associated with high potassium clearance, suppressed plasma renin activity, metabolic alkalosis, and normal blood pressure as well as low urinary excretion of 17-hydroxycorticosteroids. He kept normotensive in spite of hyperaldosteronism until nine months after the initiation of replacement therapy with glucocorticoid and thyroxine for hypopituitarism, when he became hypertensive. Hypopituitarism seemed to play a role in keeping a normal blood pressure despite long-standing hyperaldosteronism.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kuroda
authors.forename: K
authors.initials: K
authors.lastname: Okamura
authors.forename: M
authors.initials: M
authors.lastname: Yoshinari
authors.forename: H
authors.initials: H
authors.lastname: Ikenoue
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: S
authors.initials: S
authors.lastname: Takishita
authors.forename: M
authors.initials: M
authors.lastname: Fujishima
mesh_terms: D000311:Adrenal Glands / Q000000981:diagnostic imaging; D001921:Brain / Q000000981:diagnostic imaging; D004827:Epilepsy / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D007018:Hypopituitarism / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D007691:Medullary Sponge Kidney / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008875:Middle Aged; D014057:Tomography, X-Ray Computed