Ethyl chloride: 11-day continuous exposure inhalation toxicity study in B6C3F1 mice.
Groups of seven B6C3F1 mice per sex were exposed for 23 hr/day to 0, 250, 1250, or 5000 ppm ethyl chloride (EtCl) for 11 consecutive days to evaluate the potential toxicity of EtCl under near-continuous exposure conditions. On the day following the last exposure, a neurobehavioral observation battery was performed, samples were obtained for clinical chemistry and hematology, and necropsies were conducted. Histopathologic examination was subsequently performed. The only observed effects were increased relative liver weights and a slight increase in hepatocellular vacuolation (glycogen or fat) in 5000 ppm-exposed mice. Exposures to EtCl were well tolerated despite the unusually long exposure periods.
Landry
T D
TD
Mammalian and Environmental Toxicology Research Laboratory, Dow Chemical Company, Midland, Michigan 48674.
Johnson
K A
KA
Phillips
J E
JE
Weiss
S K
SK
D000280:Administration, Inhalation; D000818:Animals; D001273:Atmosphere Exposure Chambers; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005018:Ethyl Chloride / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D008297:Male; D008737:Methyl Chloride / Q000008:administration & dosage / Q000633:toxicity; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects
D005018:Ethyl Chloride; D008737:Methyl Chloride