9.4-T NMR microimaging studies of hepatic metastases of human colorectal tumors in nude mice.
We have applied NMR microimaging at 9.4 T to detect metastatic deposits in the liver of nude mice noninvasively, using an animal model for metastatic colon cancer that mimics several aspects of the human disease. Images were obtained with a resolution of 100 x 100 x 900 microns and the tumor deposits were clearly distinguished from the normal liver tissue with excellent contrast. Comparison of NMR images with corresponding histologic sections indicates that lesions as small as 900 microns were detected.
Sarkar
S K
SK
Smith Kline & French Laboratory, King of Prussia, Pennsylvania 19406.
Clark
R K
RK
Rycyna
R E
RE
Mattingly
M A
MA
Greig
R
R
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D003110:Colonic Neoplasms / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation