title: [Regularities of formation in a general population of serum antibodies to previously circulated influenza A viruses].
abstract: The spectrum of antibody production against hemagglutinin of all known influenza A virus serotypes after influenza A (H3N2) infection in persons of all age groups (from 1 month to 72 years) was analysed to investigated the regularities of accumulation of antibodies against influenza A viruses gone out of circulation. For the same purpose, a long-term (many years) longitudinal analysis of serum anti-HA antibody levels against "old" influenza A (HSW1N1), A (H0N1), A (H1N1), A (H2N2), and A (H3N2) viruses was carried out in children and adults of various age groups in 6 cities of different geographical regions of the country. Based on the results of the study, the concept of the "original antigenic sin" is analysed critically, and a new original concept on the regularities of antibody genesis against previously prevalent influenza A viruses and the factors affecting this process has been formulated.
authors.forename: A N
authors.initials: AN
authors.lastname: Naĭkhin
authors.forename: L G
authors.initials: LG
authors.lastname: Katorgina
authors.forename: T N
authors.initials: TN
authors.lastname: Kim
authors.forename: I M
authors.initials: IM
authors.lastname: Krotova
authors.forename: G M
authors.initials: GM
authors.lastname: Denisov
authors.forename: N V
authors.initials: NV
authors.lastname: Trusov
authors.forename: V N
authors.initials: VN
authors.lastname: Reznik
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002648:Child; D002675:Child, Preschool; D006386:Hemagglutination Tests; D006801:Humans; D007223:Infant; D009980:Influenza A virus / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology; D008137:Longitudinal Studies; D008875:Middle Aged; D014586:USSR
chemical_list: D000914:Antibodies, Viral
vernacular_title: Zakonomernosti obrazovaniia u naseleniia syvorotochnykh antitel k ranee tsirkulirovavshim virusam grippa A.