Oxypurinol attenuates ischemia-induced hippocampal damage in the gerbil.
Oxypurinol, an inhibitor of the enzyme xanthine oxidase, reduced ischemic hippocampal damage and the associated hypermotility in Mongolian gerbils. Cerebral ischemia was induced in unanesthetized gerbils by a bilateral 5-min occlusion of the carotid arteries. Oxypurinol (40 mg/kg, IP), administered 20 min prior to carotid occlusion, prevented the increase in locomotor activity observed in saline-injected ischemic animals and significantly reduced the damage to, and loss of, CA1 hippocampal neurons observed 5 days postischemia. These findings suggest that oxypurinol may be useful for the prevention of cerebral ischemic damage.
Phillis
J W
JW
Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201.
D000818:Animals; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D008297:Male; D010117:Oxypurinol / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D014969:Xanthine Oxidase / Q000378:metabolism*
D004791:Enzyme Inhibitors; D011743:Pyrimidines; D014969:Xanthine Oxidase; D010117:Oxypurinol