title: The effect of nitroimidazole and photochemotherapy on solid Ehrlich carcinomas.
abstract: The photodynamic effect of activated hematoporphyrin in combination with the radiosensitizer nitroimidazole was investigated. The tumor model used was the solid Ehrlich carcinoma, He-Ne laser was chosen as the light source. A significant difference between the tumor masses of control animals and the tumor masses of treated animals was recorded. It is possible that the photodynamic processes are based on Type I photooxidation. Especially in the treatment of hypoxic areas of tumors the additional administration of nitroimidazole may be important.
authors.forename: K
authors.initials: K
authors.lastname: König
authors.forename: V
authors.initials: V
authors.lastname: Bockhorn
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D051379:Mice; D009368:Neoplasm Transplantation; D010778:Photochemotherapy; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*
chemical_list: D011838:Radiation-Sensitizing Agents; D008795:Metronidazole