[Gallopamil and chlorthalidone versus atenolol and chlorthalidone in the treatment of obstructive hypertrophic cardiomyopathy in patients with arterial hypertension: polycardiographic evaluation of the systolic and diastolic function of the left ventricle].
In 13 patients, affected by hypertrophic obstructive cardiomyopathy (HOCM) and essential hypertension, antihypertensive-efficacy and effects of a new calcium-channel blocker (gallopamil) associated with a diuretic agent (chlorthalidone) on left ventricular systolic and diastolic performance assessed by phonocardiographic methods. The results were compared to those obtained, in the same group of patients, with a selective beta-blocker (atenolol) associated with the same diuretic agent (chlorthalidone). With both therapeutic regimens a statistically significant reduction of systolic and diastolic arterial pressure was observed; both agents were able to reduce hemodynamic gradient in systole which characterize HOCM; however, the treatment with gallopamil plus chlorthalidone determined greater effects on left ventricular diastolic function as compared to the treatment with atenolol plus chlorthalidone; both treatments determined bradycardia.
Chieppa
S
S
Lobascio
C
C
Brandini
V
V
Iarussi
D
D
Giuliani
F
F
Langella
S
S
De Simone
R
R
D000328:Adult; D000368:Aged; D001262:Atenolol / Q000627:therapeutic use*; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000188:drug therapy*; D002752:Chlorthalidone / Q000627:therapeutic use*; D003971:Diastole / Q000187:drug effects; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005711:Gallopamil / Q000627:therapeutic use*; D006352:Heart Ventricles; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D013599:Systole / Q000187:drug effects
D005711:Gallopamil; D001262:Atenolol; D002752:Chlorthalidone
Gallopamil e clortalidone versus atenololo e clortalidone nella terapia della cardiomiopatia ipertrofica ostruttiva di pazienti con ipertensione arteriosa: valutazione policardiografica della funzione sistolica e diastolica ventricolare sinistra.