[Comparison of effects on carbohydrate metabolism of hypotension induced by sodium nitroprusside and a nitroprusside-trimetaphan mixture in rabbits].
Effects on carbohydrate metabolism of hypotension induced by sodium nitroprusside and a nitroprusside-trimetaphan mixture were studied in 29 male rabbits under halothane anesthesia. They were randomly divided into three groups; Nitroprusside (Group N; n = 10), A Nitroprusside-Trimetaphan Mixture (Group M; n = 10), Control (Group C; n = 9). No changes were noted in blood glucose, blood lactate, blood pyruvate and lactate/pyruvate ratio in Group C throughout the experiment. During induced hypotension, blood glucose, blood lactate, blood pyruvate and L/P ratio of group N were significantly higher than the control value. On the other hand, in group M, blood glucose and blood pyruvate tended to increase slightly but not significantly. In contrast, in group M, L/P ratio remained unchanged. The results suggest that sodium nitroprusside tended to cause tissue hypoxia more markedly than a nitroprusside-trimetaphan mixture. The mechanism may be that a mixture of nitroprusside and trimetaphan maintained the carbohydrate metabolism (including gluconeogenesis, glucogenolysis) during induced hypotension. In conclusion, our results suggest that a nitroprusside-trimetaphan mixture is a safe method for hypotensive anesthesia.
Takeda
S
S
Inada
Y
Y
Tomaru
T
T
Matsui
K
K
Ikeda
T
T
Morimoto
F
F
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D004338:Drug Combinations; D005292:Ferricyanides / Q000494:pharmacology*; D007023:Hypotension, Controlled; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D009599:Nitroprusside / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D011817:Rabbits; D014294:Trimethaphan / Q000494:pharmacology*
D001786:Blood Glucose; D004338:Drug Combinations; D005292:Ferricyanides; D007773:Lactates; D011773:Pyruvates; D009599:Nitroprusside; D019344:Lactic Acid; D014294:Trimethaphan; D019289:Pyruvic Acid