[The relationship between the prostaglandin E level in the tumor and the times of the metastasis of primary osteogenic sarcoma].
Radioimmunoassay was used in 46 cases of osteogenic sarcoma to assess prostaglandin E (PgE) levels in tumor tissue. Those levels were found to vary with age. A correlation was established between the effect of preoperative chemoradiation treatment, on the one hand, and degree of treatment-induced pathomorphosis and PgE concentration in tumor, on the other. High PgE level in osteogenic sarcoma tissue proved prognostically unfavorable whatever age and prior chemoradiation treatment and were associated with shorter metastasis-free survival.
Bassalyk
L S
LS
Kushlinskiĭ
N E
NE
Solov'ev
Iu N
IuN
Siniukov
P A
PA
Fedenko
A N
AN
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism; D001859:Bone Neoplasms / Q000032:analysis* / Q000628:therapy; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D009362:Neoplasm Metastasis; D012516:Osteosarcoma / Q000032:analysis* / Q000628:therapy; D011300:Preoperative Care; D011458:Prostaglandins E / Q000032:analysis*; D011863:Radioimmunoassay; D013997:Time Factors
D011458:Prostaglandins E
Sviaz' mezhdu urovnem prostaglandinov E v opukholi i srokami metastazirovaniia pervichnoĭ osteogennoĭ sarkomy.