Oral lichenoid reactions during antimalarial prophylaxis with sulphadoxine-pyrimethamine combination.
The prevalence of clinically observed oral lichenoid reaction in 186 Malay army personnel using Fansidar for 9 weeks was found to be 4.8%. The prevalence was found to be 0.5% in 186 army personnel who had stopped using Fansidar for 2 months and 0% in 143 army personnel (control group) who had not used Fansidar for at least 4 months. The lesion showed a higher prevalence for the gingiva. There was no correlation between cigarette smoking and the occurrence of these lesions in each group.
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Department of Oral Pathology and Oral Medicine, Dental Faculty, University of Malaya, Kuala Lumpur.
D000328:Adult; D004359:Drug Therapy, Combination; D006801:Humans; D008010:Lichen Planus / Q000139:chemically induced*; D008288:Malaria / Q000517:prevention & control*; D008296:Malaysia; D008297:Male; D009059:Mouth Diseases / Q000139:chemically induced*; D011739:Pyrimethamine / Q000009:adverse effects*; D013413:Sulfadoxine / Q000009:adverse effects*; D013424:Sulfanilamides / Q000009:adverse effects*
D013424:Sulfanilamides; D013413:Sulfadoxine; D011739:Pyrimethamine