title: Non-Hodgkin's lymphoma diagnosis aided by the S.A.M. system.
abstract: In the attempt to discriminate between centroblasts and immunoblasts, an analytical morphometrical procedure was adopted, considering the nuclei of a randomly selected centroblastic and immunoblastic population from non-Hodgkin's lymphomas and the nucleoli of a more restricted number of the same neoplastic population. All the size-independent shape-descriptor parameters extracted for each step of the mathematical analyses used were submitted to Hotelling's multivariate discriminant analysis that enabled us to achieve a good distinction (3% error) between centroblasts and immunoblasts when nuclear and nucleolar parameters were used together.
authors.affiliation: Institute of Pathological Anatomy, Anthropology, University of Bari, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Ricco
authors.forename: G
authors.initials: G
authors.lastname: De Benedictis
authors.forename: T
authors.initials: T
authors.lastname: Lettini
authors.forename: V
authors.initials: V
authors.lastname: Pesce Delfino
authors.forename: A
authors.initials: A
authors.lastname: Gentile
authors.forename: A
authors.initials: A
authors.lastname: Pennella
authors.forename: G
authors.initials: G
authors.lastname: Serio
mesh_terms: D002467:Cell Nucleus / Q000473:pathology; D016002:Discriminant Analysis; D005583:Fourier Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology* / Q000648:ultrastructure; D014741:Video Recording