Biological aspects of long-term failure of autografts after cruciate ligament replacement.
The alterations of the ultrastructure of the posterior cruciate ligament autograft of patellar tendon origin were examined in a sheep model 1 year after surgery. The ultrastructure was also compared with that of the normal contralateral posterior cruciate ligament and patellar tendon. The most striking finding was the unimodal distribution of the collagen fibrils, with a predominance of loosely packed thin fibrils in the central portion of the autograft. The results suggested that the remodeled autograft tissue became highly organized but never exhibited the ultrastructural features of a ligament. This could be responsible for the decreased biomechanical properties and the long-term failure of a patellar tendon autograft.
Bosch
U
U
Unfallchirurgische Klinik, Medizinische Hochschule, Hannover, Federal Republic of Germany.
Decker
B
B
Kasperczyk
W
W
Oestern
H J
HJ
Tscherne
H
H
D000818:Animals; D007718:Knee Injuries / Q000601:surgery*; D008023:Ligaments, Articular / Q000637:transplantation* / Q000648:ultrastructure; D012756:Sheep; D014184:Transplantation, Homologous