[Preventive effects of fortified pollen on diphenylhydantoin teratogenesis].
This paper reports the preventive effects of fortified pollen and folic acid on diphenylhydantoin (DPH) teratogenesis in pregnant SD rats. The experiment showed that i.p. injection of DPH 75mg/kg per day to pregnant rats on gestational days 7 through 11, and feeding of fortified pollen (pollen 10g/kg per day plus folic acid 20mg/kg per day) or folic acid (20mg/kg per day) on gestational days 0 through 20 may partly prevent the embryotoxicity and fetal toxicity produced by DPH. However, the preventive effects of fortified pollen is better than those of folic acid on the following: decrease of fetal body weight; retarded ossification of metacarpus, proximal phalanx, metatarsus, and supraoccipital bone; sternebrae ossification agenesis; subcutaneous hemorrhage; single eye defect; hydronephrosis and the widening of subarachnoid space. This paper also discusses the possible mechanism of prevention of fortified pollen and folic acid against DPH teratogenesis.
Zhang
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Zhou
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D000014:Abnormalities, Drug-Induced / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D004357:Drug Synergism; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D010672:Phenytoin; D011058:Pollen; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D010672:Phenytoin; D005492:Folic Acid