[Differential diagnosis of drug-induced liver damage. Problems and conclusions from the viewpoint of the clinician].
Our analysis showed that in of more than 80% of the patients admitted to the infection hospital because of suspicion of viral hepatitis there is also an anamnesis of one or several drugs. Among 2944 patients, admitted with being suspect of having viral hepatitis, there were 128 patients (adequate to 4.4%) with a drug-induced liver injury diagnosed in the result of all clinical, serological, histological and immunological findings. Inducing noxes were - in accordance to the frequency of ordination - ovulation inhibitors followed by Berlocombin, Ketazon, Depressan and Obsidan. In view of a clinic for infectious diseases it has to be pointed to the necessity of a high degree of security in the differential diagnosis of the drug-induced liver injury in relation to the viral hepatitis and one has to consider the great responsibility of the clinician. Often a decision may only be taken in close interdisciplinary collaboration of gastroenterologists, pathologists, epidemiologists and immunologists.
Wiese
M
M
Klinik für Infektions- und Tropenkrankheiten, Bezirkskrankenhauses St. Georg, Leipzig.
Haupt
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006525:Hepatitis, Viral, Human / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged
Zur Differentialdiagnose des arzneimittelbedingten Leberschadens (ALS). Probleme und Schlussfolgerungen aus der Sicht des Klinikers.