Indomethacin (i.c.v.) reverses the inhibitory action of peptides on gastric secretion.
Central administration of diverse peptides, such as dermorphin (100 ng), salmon calcitonin (250 ng), human-corticotropin-releasing-factor (10 micrograms) and human-calcitonin-gene-related-peptide (10 micrograms) inhibited gastric acid secretion in pylorus-ligated rats. With the exception of salmon calcitonin this suppressive effect was significantly reversed by the central administration of 400 micrograms indomethacin. These data suggest that the gastric inhibitory effect of dermorphin, human-corticotropin-releasing-factor and human-calcitonin-gene-related-peptide might be mediated by the central synthesis of a cyclooxygenase product(s).
Guglietta
A
A
Glaxo Research Laboratories, Research Triangle Park, NC 27709.
Nardi
R V
RV
Lazarus
L H
LH
D000818:Animals; D002116:Calcitonin / Q000494:pharmacology; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology; D018847:Opioid Peptides; D010455:Peptides / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains
D009842:Oligopeptides; D018847:Opioid Peptides; D010455:Peptides; C030058:dermorphin; D002116:Calcitonin; D003346:Corticotropin-Releasing Hormone; D015740:Calcitonin Gene-Related Peptide; D007213:Indomethacin