[The role of peripheral cholinergic and adrenergic receptor systems in the action of histamine on the isolated coronary arteries].
The action of peripheral cholinergic and adrenergic receptor systems on the histamine coronary vasospastic effects are investigated in the experiments on the isolated ring-shaped strips of coronary arteries of pigs with the aid of specific agonists and antagonists. It has been demonstrated that neuromediator systems play a significant role in the regulation of contractile activity of the coronary spasm pathogenesis. When medicines are prescribed to patients with ischemic heart disease it is necessary to take into account the character of the preparations interaction which affect the peripheral neuromediator processes such as histaminergic, cholinergic, adrenergic and others.
Karachentsev
A N
AN
Baranov
A G
AG
D000818:Animals; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000209:etiology*; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006632:Histamine / Q000494:pharmacology / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D013552:Swine
D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D006632:Histamine
Ro'l perifericheskoĭ kholinergicheskoĭ i adrenergicheskoĭ retseptsii v deĭstvii gistamina na izolirovannye koronarnye arterii.