[Experimental chemotherapy of alveolar hydatid disease. 12. The efficacy of drug forms of mebendazole and nocodazole with high bioavailability].
New formulations have been designed to increase the efficacy and bioavailability of the oral drugs mebendazole and nocodazole and were tested in CBA mice. A considerable increase in efficacy was established for a solid disperse formulation of certain composition with a relatively lower toxicity than in aqueous suspensions of the drugs.
Dzhabarova
V I
VI
Dobrotvorskiĭ
A E
AE
Krotov
A I
AI
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004353:Drug Evaluation, Preclinical; D004443:Echinococcosis / Q000188:drug therapy*; D007273:Injections, Intramuscular; D008463:Mebendazole / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D051379:Mice; D008808:Mice, Inbred CBA; D015739:Nocodazole / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D012995:Solubility; D013535:Suspensions
D013535:Suspensions; D008463:Mebendazole; D015739:Nocodazole
Eksperimental'naia khimioterapiia al'veokokkoza. Soobshchenie 12. Effektivnost' lekarstvennykh form mebendazola i nokodazola s povyshennoĭ biostupnost'iu.