Liver mitochondrial respiratory functions decline with age.
Human liver mitochondrial respiration rates in Chinese populations of various ages were assayed with an oxygraph. In this study, State 3 and State 4 respiration rates, respiratory control ratio (RCR), and ADP/O ratio were measured for 35 Chinese subjects of 31 to 76 years old. We found a significant negative correlation between age and respiratory control and ADP/O ratios tested. Moreover, the respiratory control and ADP/O ratios decreased with the increase of age. These findings suggest that a substantial fall in mitochondrial oxidative capacity in ageing liver may be an important contributor to the ageing process.
Yen
T C
TC
Department of Biochemistry, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China.
Chen
Y S
YS
King
K L
KL
Yeh
S H
SH
Wei
Y H
YH
D000244:Adenosine Diphosphate / Q000378:metabolism; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*
D000244:Adenosine Diphosphate