Induced circular dichroism in nucleic acid-acridine derivative complexes.
Visible absorption and circular dichroism (CD) spectra have been measured for complexes formed between nucleic acids (calf thymus DNA, poly(rA).poly(rU) and poly(rI).poly(rC)) and 9-aminoacridines (quinacrine, acranil and 9-amino-6-chloro-2-methoxy acridine). With poly(rA).poly(rU), a new absorption band was observed at longer wavelengths. The nucleic acid-drug complexes showed considerable different induced CD spectra. Analysis of these CD spectra suggests that the cationic side chains of quinacrine and acranil play an important role on the binding properties to DNA and poly(rA).poly(rU).
Tani
S
S
Department of Chemistry, Faculty of Science, Yamaguchi University, Japan.
Kubota
Y
Y
D000166:Acridines / Q000378:metabolism*; D000585:Aminacrine / Q000031:analogs & derivatives / Q000378:metabolism; D000609:Aminoacridines / Q000378:metabolism; D002942:Circular Dichroism; D004247:DNA / Q000378:metabolism*; D011063:Poly A-U / Q000378:metabolism; D011070:Poly I-C / Q000378:metabolism; D011796:Quinacrine / Q000378:metabolism
D000166:Acridines; D000609:Aminoacridines; D011063:Poly A-U; C010847:9-amino-6-chloro-2-methoxyacridine; D000585:Aminacrine; D004247:DNA; D011796:Quinacrine; D011070:Poly I-C; C006397:acranil