Pulsatile release of acetylcholinesterase from the substantia nigra following electrical stimulation of the striatum.
The spatio-temporal characteristics of release of acetylcholinesterase from the in vivo substantia nigra can now be described using a chemiluminescent reaction. Electrical stimulation of the striatum caused an increase in release of acetylcholinesterase within the ipsilateral substantia nigra; however, this increase in release of protein was non-uniform and pulsatile. The findings suggest that release of acetylcholinesterase within the substantia nigra has a fine space-time resolution never before appreciated.
Taylor
S J
SJ
University Department of Pharmacology, Oxford U.K.
Greenfield
S A
SA
D000110:Acetylcholinesterase / Q000493:pharmacokinetics*; D000818:Animals; D002093:Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide / Q000494:pharmacology; D003342:Corpus Striatum / Q000502:physiology*; D004558:Electric Stimulation; D006168:Guinea Pigs; D008297:Male; D009434:Neural Pathways; D013378:Substantia Nigra / Q000378:metabolism*
D002093:Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; D000110:Acetylcholinesterase