title: 2308 second trimester terminations using extra-amniotic or intra-amniotic prostaglandin E2: an analysis of efficacy and complications.
abstract: A total of 2308 mid-trimester terminations using PGE2 extra-amniotically (1608) or intra-amniotically (700) has been analysed for efficacy and immediate and early morbidity. The mean induction-to-abortion intervals were similar for the two routes. Overall, 67% of the patients were in hospital for 1 night. Morbidity rates were similar for the two administration routes and were no higher than those reported for second trimester terminations using dilatation and evacuation. Minor side-effects of vomiting occurred in 1006 (44%) and diarrhoea in 320 (14%). Forty (1.7%) lost more than 500 ml of blood during termination and 13 (0.6%) were transfused. Major complications were extremely rare and genital tract trauma only occurred in 4 (0.17%) and proven pelvic infection in 2 (0.08%) patients. Thirty-three (1.4%) were readmitted and required a surgical evacuation of the uterus. Since long-term complications have been assessed for this method of termination and found to be infrequent, we see no reason to consider a change in methods for second trimester terminations.
authors.affiliation: Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital.
authors.forename: N C
authors.initials: NC
authors.lastname: Hill
authors.forename: I Z
authors.initials: IZ
authors.lastname: MacKenzie
mesh_terms: D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D015232:Dinoprostone / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005334:Fever / Q000209:etiology; D005836:Genitalia, Female / Q000293:injuries; D006801:Humans; D007239:Infections / Q000209:etiology; D007902:Length of Stay; D010359:Patient Readmission; D006473:Postpartum Hemorrhage / Q000209:etiology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D013997:Time Factors; D014839:Vomiting / Q000209:etiology
chemical_list: D015232:Dinoprostone