Calcium-dependent potassium current following penicillin-induced epileptiform discharges in the hippocampal slice.
Penicillin-induced paroxysmal depolarization shifts (PDS) are followed by prolonged afterhyperpolarizations of about 2 seconds duration. Intracellular injection of EGTA blocked a late component of the afterhyperpolarizations; an early one lasting up to one second was only slightly reduced by EGTA. It is concluded that afterhyperpolarizations following penicillin-induced PDS comprise different components: an initial one lasting up to one second which is not Ca2+-dependent and a slow one lasting up to two seconds which is caused by a Ca2+-dependent K+ current.
Domann
R
R
Neurologische Universitätsklinik, Düsseldorf, Federal Republic of Germany.
Dorn
T
T
Witte
O W
OW
D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000502:physiology*; D004827:Epilepsy / Q000139:chemically induced* / Q000503:physiopathology; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D010406:Penicillins; D011188:Potassium / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D010406:Penicillins; D011188:Potassium; D002118:Calcium