title: Accumulation of lipofuscin in the brain of the frog, Rana temporaria, subjected to treatment with ultrasound.
abstract: Sexually mature male and female frogs, Rana temporaria L., taken from their natural habitat at the end of the hibernation period, were subjected to treatment with ultrasound of various duration. The ultrasound (frequency, 24 kHz, intensity 0.35 W/cm2) was applied over the whole body in a suitable water bath. Neurons of the nucleus infundibularis dorsalis, medulla oblongata, and the subfornical organ were studied. A considerable increase in the amount of autofluorescent lipofuscin pigment was observed in nerve cells of various regions of the brain of the treated animals. The largest amounts of the lipofuscin pigment were found in those treated for one hour and killed on the fourteenth day following sonication.
authors.forename: Z
authors.initials: Z
authors.lastname: Srebro
authors.forename: H
authors.initials: H
authors.lastname: Lach
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D008062:Lipofuscin / Q000378:metabolism*; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000378:metabolism; D010860:Pigments, Biological / Q000378:metabolism*; D011896:Rana temporaria / Q000378:metabolism*; D014464:Ultrasonic Therapy
chemical_list: D008062:Lipofuscin; D010860:Pigments, Biological