Regional localization of the gene encoding pregnancy specific beta-1-glycoprotein 1 (PSBG1) to human chromosome 19q13.1.
Pregnancy specific beta-1-glycoprotein (PSBG), a major product of the human placenta, is encoded by multiple genes. Southern blot hybridization of human x rodent somatic cell hybrid DNAs with a cDNA specific for one member of the PSBG gene family allowed us to map this gene to human chromosome 19. Further analysis using hybrids with subchromosomal segments of 19q revealed that the gene maps to the distal segment of region 19q13.1.
Niemann
S C
SC
Institut für Humangenetik der Universität, Göttingen, FRG.
Schonk
D
D
van Dijk
P
P
Wieringa
B
B
Grzeschik
K H
KH
Bartels
I
I
D000818:Animals; D015139:Blotting, Southern; D002272:Carcinoembryonic Antigen / Q000235:genetics; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D015342:DNA Probes; D006801:Humans; D006822:Hybrid Cells; D005810:Multigene Family; D011257:Pregnancy Proteins / Q000235:genetics*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000235:genetics*
D002272:Carcinoembryonic Antigen; D015342:DNA Probes; D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins