Spectroscopic and biological investigation of nimbolide and 28-deoxonimbolide from Azadirachta indica.
The reisolation of nimbolide [1] from Azadirachta indica of Tanzanian origin and the isolation and structure elucidation of a new limonoid, 28-deoxonimbolide [2], from the same plant source are reported. For the first time, unambiguous 1H- and 13C-nmr assignments of compounds 1 and 2 are presented, as well as their in vitro cytotoxic activity against human tumor cell lines.
Kigodi
P G
PG
Program for Collaborative Research in the Pharmaceutical Sciences, University of Illinois, College of Pharmacy, Chicago 60680.
Blaskó
G
G
Thebtaranonth
Y
Y
Pezzuto
J M
JM
Cordell
G A
GA
D000972:Antineoplastic Agents, Phytogenic; D002770:Cholenes / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology; D036701:Limonins; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000032:analysis*; D012632:Secosteroids / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D002770:Cholenes; D007783:Lactones; D036701:Limonins; D012632:Secosteroids; C062897:28-deoxonimbolide; C042198:nimbolide