[Human peritoneum in vitro: changes in urate transport after administration of pyrazinoic acid].
The article is an analysis of the dynamics of two-direction transportation of uric acid (UA) through the human peritoneum in vitro, and also changes of the dynamics under the influence of pyrazinoic++ acid. The peritoneum was taken from the anterior abdominal wall of patients undergoing planned abdominal surgery. It was found that the transportation of UA both from the vascular to the mesothelial side of the peritoneal membrane and in the opposite direction remained on a stable level for 120 minutes. The introduction of pyrazinoic++ acid decreased the transportation of UA from the vascular to the mesothelial side of the peritoneum on the average by 50 per cent. The transportation in the opposite direction did not change. The results obtained are consistent with results of clinical examinations. One may suppose that pyrazinoic++ acid induces changes in transportation qualities of the peritoneum.
Czyzewska
K
K
Grzegorzewska
A
A
Stawny
B
B
Knapowski
J
J
D000328:Adult; D000368:Aged; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010537:Peritoneum; D011718:Pyrazinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D014527:Uric Acid / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics*
D014527:Uric Acid; D011718:Pyrazinamide; C005296:pyrazinoic acid
Otrzewna ludzka in vitro: zmiany w transporcie moczanów pod wpływem kwasu pirazynowego.