Effects of aspirin-like drugs on Walker 256 tumor growth and cachexia in rats.
Several studies have shown the relationship between prostaglandins (PGs) and cell proliferation. Some PGs may trigger cell division or are involved in this process. This study analyzes the effect of PG biosynthesis inhibitors on tumor growth in vivo and cachexia in Walker 256 tumor-bearing rats. Indomethacin markedly inhibited tumor growth (95.5%) while ibuprofen and aspirin reduced tumor growth by 73.9% and 59.4%, respectively. In addition, all drug-treated rats partially recovered body weight and food intake as compared to the saline-treated group. These findings suggest that PG synthesis inhibitors improve cancer cachexia.
Homem-de-Bittencourt Júnior
P I
PI
Departamento de Fisiologia e Biofísica, Universidade de São Paulo, Brasil.
Pontieri
V
V
Curi
R
R
Lopes
O U
OU
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D001835:Body Weight; D002100:Cachexia / Q000188:drug therapy; D002279:Carcinoma 256, Walker / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D007052:Ibuprofen / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009368:Neoplasm Transplantation; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011458:Prostaglandins E / Q000097:blood; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin