[Establishing the structure of anthracyclinones produced by Streptomyces griseoruber].
Streptomyces grisoruber strain 1618-306 produces three types of anthracycline antibiotics, derivatives of epsilon-pyrromycinone (methyl (7S, 9R, 10R)-9-ethyl-5,7,8,9,10,12-hexahydro-1,4,6,7,9-pentahydroxy-5,12-di oxo-10- naphthacenecarboxylate), epsilon-1-hydroxyauramycinone and epsilon-1-hydroxysulfurmycinone, differing in C-9 substituent in D ring of anthracyclines (Et, Met or CH2COCH3, respectively). Besides 7-O-glycosides of these aglycones, complex of antibiotics contains corresponding 7-deoxy- and 7,8,9,10-bisanhydroanthracyclinones.
Bakina
E V
EV
Iartseva
I V
IV
Povarov
L S
LS
Aleksandrova
L G
LG
Tulemisova
K A
KA
Mamonova
L P
LP
Preobrazhenskaia
M N
MN
D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000096:biosynthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D013058:Mass Spectrometry; D008968:Molecular Conformation; D013302:Streptomyces / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic
Ustanovlenie stroeniia antratsiklinonov, produtsiruemykh Streptomyces griseoruber.