[Modeling, using nucleases, of the effect of radiation on Chinese hamster fibroblasts. On the role of single-stranded DNA breaks, induced by DNAase I, in the initiation of chromosome aberrations].
DNAase I injected to Chinese hamster fibroblast cells resulted in the chromosome aberration induction at all stages of the cell cycle and death of cells. Comparison of the effects of DNAase I and gamma-radiation on Chinese hamster cells showed that with close values of the induced DNA breaks there were close values of the cytogenetic damage and the number of DNA damages per aberrant cell.
Ganassi
E E
EE
Zaichkina
S I
SI
Rozanova
O M
OM
D000818:Animals; D002869:Chromosome Aberrations; D006224:Cricetinae; D004249:DNA Damage; D004277:DNA, Single-Stranded / Q000187:drug effects* / Q000528:radiation effects; D003850:Deoxyribonuclease I / Q000494:pharmacology*; D066298:In Vitro Techniques; D008957:Models, Genetic
D004277:DNA, Single-Stranded; D003850:Deoxyribonuclease I
Modelirovanie s pomoshch'iu nukleaz deĭstviia radiatsii na fibroblasty kitaĭskogo khomiachika. O roli odnonitevykh razryvov DNK, indutsirovannykh DNKazoĭ I, v initsiatsii khromosomnykh narusheniĭ.