title: Determination of 3 beta-hydroxylated bile acids in human serum and liver tissue.
abstract: 3 beta, 7 alpha-Dihydroxy-5 beta-cholanoic acid (3 beta, 7 alpha-diOH) was detected in serum of 3 patients with intrahepatic cholestasis. 3 beta, 7 beta-dihydroxy-5 beta-cholanoic acid (3 beta, 7 beta-diOH) appeared in serum of those patients after treatment with ursodeoxycholic acid (UDC). These bile acids were also detected in only unconjugated fractions of serum of another 7 patients with chronic liver diseases, but not in liver tissue of them. The liver does not seem to from these bile acids itself because they were absent in liver tissue.
authors.affiliation: Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai.
authors.forename: T
authors.initials: T
authors.lastname: Nagakura
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: M
authors.initials: M
authors.lastname: Otsuki
authors.forename: J
authors.initials: J
authors.lastname: Goto
authors.forename: T
authors.initials: T
authors.lastname: Nambara
authors.forename: T
authors.initials: T
authors.lastname: Toyota
mesh_terms: D001647:Bile Acids and Salts / Q000097:blood / Q000378:metabolism*; D002780:Cholestasis, Intrahepatic / Q000378:metabolism*; D006801:Humans; D008107:Liver Diseases / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D001647:Bile Acids and Salts