The effect of gossypol on serum lipoproteins of adult rats.
It has been shown that gossypol treatment brings about marked changes in plasma lipoproteins of certain species causing a marked fall in total cholesterol and LDL-cholesterol levels. Using Helena electrophoretic system the lipoprotein pattern in serum of adult rats treated with gossypol was studied. Gossypol treatment for 1 day and 7 days continuously did bring about changes in serum lipoprotein profile. A marked increase in VLDL-cholesterol and fall in LDL-cholesterol was observed in rats treated with gossypol which was more pronounced in the 7 days treated group. It did not bring about any marked change in total cholesterol level. It did cause an increase in serum triglyceride level. Heparin injection which brought about a fall in VLDL-cholesterol with a concomitant increase in HDL-cholesterol in control rats did not elicit changes in gossypol-treated rats. Thus, gossypol treatment appears to alter serum lipoprotein metabolism in rats also.
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Department of Zoology, Garyovnis University, Benghazi, Libya.
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Sheriff
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D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002784:Cholesterol / Q000378:metabolism; D004586:Electrophoresis; D006072:Gossypol / Q000494:pharmacology*; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D008074:Lipoproteins; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D006072:Gossypol