[Intravenous versus oral treatment of endogenously depressed patients with doxepin--a double-blind study with plasma level determination].
A double-blind study was conducted involving 45 "therapy-resistant" endogenous depressive inpatients who were treated with Doxepin intravenously or orally. After a period of 3 weeks there was no significant difference in the clinical ratings (HRSD, SDS). In the parenteral treatment group, however there was a statistically significant quicker onset of action (day 3). Compared to oral application higher Doxepin plasma concentrations during day 1 to 6 could be obtained by drip-infusion in spite of lower dosage.
Laux
G
G
Psychiatrischen Universitätsklinik Würzburg, BRD.
König
W
W
Lesch
K P
KP
Stein
A
A
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D004316:Doxepin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged
D004316:Doxepin
Intravenöse versus orale Behandlung endogen depressiver Patienten mit Doxepin--Eine Doppel-blindstudie mit Plasmaspiegelbestimmungen.