[Immunosuppresive effects of wilfortrine and euonine].
Wifortrine and Euonine isolated from Tripterygium wilfordii Hook. f. Wilfortrine and euonine (40.80 mg/(kg.d) x 4d ip) showed marked depressant effects on humoral mediated immunity using the hemolysin reaction as indices. Wilfortrine (160 mg/kg.d x 9d ip) exhibited a depressant effect on graft vs host reaction (GVHR), but wilfortrine (80 mg/(kg.d) x 9d ip) showed no definite effect. Euonine (80 mg/(kg.d) x 10d ip) showed marked suppressant effects on DNCB induced delayed hypersensitivity reaction on skin in mice. Wilfortrine and Euonine (80 mg/(kg.d) x 4d ip) significantly decreased the clearance rate of charcoal particles and the weights of spleen and thymus.
Zheng
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Xu
Y
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Lin
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JF
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002606:Charcoal / Q000493:pharmacokinetics; D005260:Female; D006087:Graft vs Host Reaction / Q000187:drug effects; D006460:Hemolysin Proteins / Q000096:biosynthesis; D006968:Hypersensitivity, Delayed; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR
D000470:Alkaloids; D006460:Hemolysin Proteins; D002606:Charcoal; C062677:wilfortrine; C062678:euonine