title: On the effects of tranexamic acid and its isobenzedrine ester on plasminogen activation and streptokinase induced fibrinolysis.
abstract: A comparison between the inhibitory capability of Tranexamic acid (AMCA) and its isobenzedrine ester (IB-AMCA) on the streptokinase and urokinase induced plasminogen activation, indicated in vitro a higher potency of the ester derivative. A peculiar activatory rather than inhibitory effect on the plasminogen activation was exerted by AMCA and aminocaproic acid at relatively low concentrations. Attempts to show in vivo the in vitro observed differences between AMCA and IB-AMCA action are reported.
authors.forename: M
authors.initials: M
authors.lastname: Baldacci
authors.forename: R
authors.initials: R
authors.lastname: Catalani
authors.forename: C
authors.initials: C
authors.lastname: Bartoli
authors.forename: A
authors.initials: A
authors.lastname: Del Corso
authors.forename: M G
authors.initials: MG
authors.lastname: Tozzi
authors.forename: U
authors.initials: U
authors.lastname: Mura
mesh_terms: D000818:Animals; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects*; D010960:Plasminogen Activators / Q000502:physiology*; D011817:Rabbits; D013300:Streptokinase / Q000037:antagonists & inhibitors / Q000494:pharmacology; D014148:Tranexamic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D003509:Cyclohexanecarboxylic Acids; C062699:tranexamic acid isobenzedrine ester; D014148:Tranexamic Acid; D013300:Streptokinase; D010960:Plasminogen Activators