Central administration of neuropeptide Y induces hypothermia in mice. Possible interaction with central noradrenergic systems.
Neuropeptide Y (0.24 and 1.17 nmol icv) and clonidine (0.025, 0.05 and 0.1 mg/Kg ip) induced a slight decrease of short duration of the rectal temperature in mice in a dose-dependent manner. While pretreatment with yohimbine (0.5 mg/Kg sc), was without effect on neuropeptide Y-induced hypothermia, it attenuated the hypothermic effect of clonidine. The association of neuropeptide Y (0.05 and 0.24 nmol icv) with clonidine (0.0125, 0.025, 0.05 and 0.1 mg/Kg ip) induced a synergistic effect, but it only was significant when neuropeptide Y 0.05 and 0.24 nmol icv was associated with clonidine 0.1 mg/Kg ip and when neuropeptide Y 0.05 nmol icv was associated with clonidine 0.05 mg/Kg ip. These results suggest that the effect of neuropeptide Y is not mediated by an interaction on alpha 2-adrenoceptor, but in accordance with these results, the existence of a collaborative mechanism between both neuropeptide Yergic and noradrenergic systems cannot be ruled out.
Esteban
J
J
Dept. Neurociencias, Facultad de Medicina, Universidad de Cádiz, España.
Chover
A J
AJ
Sánchez
P A
PA
Micó
J A
JA
Gibert-Rahola
J
J
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D003000:Clonidine / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000494:pharmacology*; D009638:Norepinephrine / Q000502:physiology*; D012016:Reference Values; D015016:Yohimbine / Q000494:pharmacology
D009478:Neuropeptide Y; D015016:Yohimbine; D003000:Clonidine; D009638:Norepinephrine