[The interaction of the coloboma and aphakia mutant genes in mice].
The eye development has been studied in the 12-day-old, 14-day-old embryos and in neonates of Cm/+ ak/ak genotype. The gene coloboma (Cm) in heterozygous state causes a typical coloboma of the iris and the gene aphakia (ak) blocks the lens development in the homozygotes. It has been shown that in Cm/+ ak/ak mice the eyes go through mainly the same abnormal development as that in +/+ ak/ak animals. In mice of both genotypes the lens morphogenesis blocking at the vesicle stage and the retinal fold in the dorsal half of the eye develops. However, the ventral retinal fold which is characteristic for the +/+ ak/ak mice does not form in the Cm/+ ak/ak animals that is the result of the interaction of Cm and ak genes in the eye morphogenesis. The Cm gene suppressing the growth of the retina ventral half inhibits the formation of its fold in Cm/+ ak/ak embryos. As a result of the gene interaction a certain normalization of the eye development compared to the +/+ ak/ak mice is observed in the Cm/+ ak/ak animals. The obtained data show that the Cm gene expresses in the cell clones of the retina ventral half.
Koniukhov
B V
BV
Sazhina
M V
MV
D000818:Animals; D001035:Aphakia / Q000196:embryology / Q000235:genetics*; D003103:Coloboma / Q000196:embryology / Q000235:genetics*; D005123:Eye / Q000196:embryology; D005260:Female; D005786:Gene Expression Regulation; D005799:Genes, Dominant; D005808:Genes, Recessive; D005838:Genotype; D007498:Iris / Q000002:abnormalities*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation
Vzaimodeĭstvie mutantnykh genov coloboma i aphakia u mysheĭ.