title: Biotin studies in pigs. 3. Biotin absorption and synthesis.
abstract: Eight pigs were given a semi-purified diet based on maize flour and casein containing 10 micrograms biotin/kg. The diet was given ad lib. with or without a supplement of 70 micrograms biotin/kg diet from 5 to 94 d of age. The flow of biotin in the stomach was similar to the biotin intake (13.5 and 112 micrograms/d) for the unsupplemented and biotin-supplemented pigs respectively. The flow of biotin through the small intestine decreased for the biotin-supplemented pigs from 39 micrograms/d in the first quarter of the small intestine to 7.9 micrograms/d in the last quarter. The flows of biotin in the caecum, large intestine and colon were similar for both the unsupplemented and biotin-supplemented pigs, with values of 17-54 micrograms/d, indicating the synthesis of biotin in the hind-gut.
authors.affiliation: Department of Animal Husbandry, University of Sydney, Camden, New South Wales, Australia.
authors.forename: J S
authors.initials: JS
authors.lastname: Kopinski
authors.forename: J
authors.initials: J
authors.lastname: Leibholz
authors.forename: W L
authors.initials: WL
authors.lastname: Bryden
mesh_terms: D000818:Animals; D001710:Biotin / Q000096:biosynthesis / Q000378:metabolism*; D004032:Diet; D005772:Gastrointestinal Transit; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism; D008297:Male; D013552:Swine / Q000378:metabolism*; D013997:Time Factors
chemical_list: D001710:Biotin