title: A comparison of the effects of 6-hydroxydopamine and reserpine on noradrenergic and peptidergic nerves in rat brown adipose tissue.
abstract: While co-existence of noradrenaline and neuropeptide-Y is, by inference, indicated in sympathetic nervous projections to rat interscapular brown adipose tissue by the fact of their coincident disappearance from the tissue following 6-hydroxydopamine treatment of the animals, reserpine treatment produced a divergent effect suggestive of possible differences either in the localisation and/or release mechanisms for noradrenaline and the peptide within the same neurons. Thus reserpine produced a depletion of noradrenaline but not of the immunohistochemically demonstrable neuropeptide-Y in the nerve plexuses of the tissue.
authors.affiliation: Department of Anatomy, University of Wales College of Cardiff, UK.
authors.forename: S
authors.initials: S
authors.lastname: Mukherjee
authors.forename: J D
authors.initials: JD
authors.lastname: Lever
authors.forename: D
authors.initials: D
authors.lastname: Norman
authors.forename: D
authors.initials: D
authors.lastname: Symons
authors.forename: T L
authors.initials: TL
authors.lastname: Spriggs
authors.forename: R T
authors.initials: RT
authors.lastname: Jung
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000294:innervation*; D000818:Animals; D009474:Neurons / Q000187:drug effects*; D009478:Neuropeptide Y / Q000378:metabolism; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000378:metabolism; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology* / Q000031:analogs & derivatives; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000378:metabolism
chemical_list: D009478:Neuropeptide Y; D012701:Serotonin; C027803:6-hydroxytryptamine; D012110:Reserpine; D009638:Norepinephrine