Pathological implications of rat liver foci and relevance to regulatory decision-making: current status and future perspective.
The purpose of this presentation is to outline regulatory decision-making for carcinogenic chemicals in Japan with special attention to the chemicals found during toxicity testing to cause liver foci in rats.
Hayashi
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National Institute of Hygienic Sciences, Division of Pathology, Tokyo, Japan.
D000818:Animals; D015197:Carcinogenicity Tests; D007564:Japan; D007883:Legislation, Medical; D008099:Liver / Q000473:pathology* / Q000648:ultrastructure; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D051381:Rats