Lack of common haplotype among four family members with late-onset Kaposi's sarcoma.
Kaposi's sarcoma is associated with an increased frequency of HLA-DR5. The hypothesized model of a susceptibility gene in linkage disequilibrium with DR5 may be tested by haplotype analysis in familial Kaposi's sarcoma. Our finding of no common haplotype among afflicted members of a family provides evidence against the hypothesized linkage.
Neefe
J R
JR
Lucille Parker Markey Cancer Center, University of Kentucky, Lexington.
Treat
J A
JA
Chun
B K
BK
Schein
P S
PS
Johnson
A H
AH
D000368:Aged; D000369:Aged, 80 and over; D004198:Disease Susceptibility; D005260:Female; D015805:HLA-DR5 Antigen / Q000235:genetics*; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D010375:Pedigree; D012514:Sarcoma, Kaposi / Q000235:genetics* / Q000276:immunology
D015805:HLA-DR5 Antigen