title: Colorado IDDM Registry: lower incidence of IDDM in Hispanics. Comparison of disease characteristics and care patterns in biethnic population.
abstract: The Colorado IDDM Registry identifies newly diagnosed cases of insulin-dependent diabetes mellitus (IDDM) throughout the state. Hispanics in Colorado are a racial mixture of American Indian and White populations. Because American Indians have a low risk of IDDM, and differing frequencies of HLA antigens and haplotypes are reported for Hispanics and non-Hispanics, we compared incidence rates and disease characteristics. Eligible participants were less than 18 yr of age and Colorado residents at time of diagnosis, diagnosed between 1 January 1978 and 31 December 1983, and on insulin within 2 wk of diagnosis. Subjects were reported by their physicians, and statewide validation of reporting was conducted through review of hospital discharge indexes. Incidence rates for Hispanics (n = 76) were significantly lower than those for non-Hispanics (n = 628), although 95% confidence intervals overlapped for children aged 10-17 yr. Age-adjusted rates were significantly lower in Hispanic than non-Hispanic males, whereas age-adjusted rates for females did not differ. The cumulative risk of IDDM was less for Hispanic males aged 0-17 yr than for non-Hispanic males (P less than .001); cumulative risk among females was males (P less than .001); cumulative risk among females was not different (P = .10). Clinical onset characteristics and medical care at diagnosis were similar. After diagnosis, hospitalizations per 100 person-yr appeared higher in Hispanics, but ketoacidosis and insulin reactions per 100 person-yr were similar. Difference in rate of hospitalizations may have been due to lower response rates among older non-Hispanics.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Preventive Medicine, University of Colorado School of Medicine, Denver 80262.
authors.forename: E C
authors.initials: EC
authors.lastname: Gay
authors.forename: R F
authors.initials: RF
authors.lastname: Hamman
authors.forename: P J
authors.initials: PJ
authors.lastname: Carosone-Link
authors.forename: D C
authors.initials: DC
authors.lastname: Lezotte
authors.forename: M
authors.initials: M
authors.lastname: Cook
authors.forename: R
authors.initials: R
authors.lastname: Stroheker
authors.forename: G
authors.initials: G
authors.lastname: Klingensmith
authors.forename: H P
authors.initials: HP
authors.lastname: Chase
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003120:Colorado; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000453:epidemiology*; D005006:Ethnicity; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D012042:Registries; D012737:Sex Factors; D011795:Surveys and Questionnaires