title: Monoclonal antibodies to study the brain in schizophrenia.
abstract: Twelve monoclonal antibodies were developed which show selective reactivity with brain tissue homogenates from 4 patients with schizophrenia compared to 4 normal controls. Certain antibodies were more reactive with tissue from cases with schizophrenia, others with control tissue. Patterns of reactivity also depended on brain region tested. Differences in reactivity generally ranged from 2- to as much as 8-fold. This panel of monoclonal antibodies may be useful to investigate the pathophysiology of schizophrenia.
authors.affiliation: Department of Genetics, New York State Psychiatric Institute, NY.
authors.forename: W G
authors.initials: WG
authors.lastname: Honer
authors.forename: C A
authors.initials: CA
authors.lastname: Kaufmann
authors.forename: J E
authors.initials: JE
authors.lastname: Kleinman
authors.forename: M F
authors.initials: MF
authors.lastname: Casanova
authors.forename: P
authors.initials: P
authors.lastname: Davies
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D001921:Brain / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000276:immunology*; D012559:Schizophrenia / Q000276:immunology* / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D009419:Nerve Tissue Proteins