title: [Cefotetan in preoperative prophylaxis in gynecologic surgery].
abstract: The Authors report on the effectiveness of a 2nd generation "cephalosporin" (Cefotetan) used in preventive antibiotic treatment connected with gynaecological surgery. Two hundred hospital patients were involved in the experiment and were divided into 4 groups: 1) the first and second groups were given a "short-term" preventive antibiotic treatment (a single dose before the operation); 2) the third and fourth groups were given antibiotics continuously in the post-operative period. In those patients in groups I and III (who had operations for abdominal laparotomies) the incidence of fewerishness was 12% in those patients treated with the "short-term" therapy, and 10% in those receiving post-operative treatment. Sepsis on the suture developed in none of these cases. Urinary infection occurred in 6% of these patients in group I as compared with 2% in group III. During post-operative treatment of patients in group II and IV (who had had minor gynaecological operation) the incidence of inflammation with slight temperature was very much lower only 4% of the cases treated with "short-term" preventive antibiotics and only 2% in those patients receiving continuous preventive treatment. In no case was these sepsis of the suture. Urinary infection occurred in 4% of patients on "short-term" therapy (group II) but in none of the patients in group IV. Side effects were in all cases only slight and of brief duration, especially in group I and II who received the single pre-operative dose of the antibiotic.
authors.forename: C
authors.initials: C
authors.lastname: Napolitano
authors.forename: R
authors.initials: R
authors.lastname: Marziani
authors.forename: B
authors.initials: B
authors.lastname: Mossa
authors.forename: B
authors.initials: B
authors.lastname: Tocci
authors.forename: M
authors.initials: M
authors.lastname: Natili
authors.forename: P
authors.initials: P
authors.lastname: Govino
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015313:Cefotetan / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D011182:Postoperative Care; D011292:Premedication; D013997:Time Factors
chemical_list: D015313:Cefotetan
vernacular_title: Il cefotetan nella profilassi preoperatoria in chirurgia ginecologica.