Performance profiles of topical antimicrobials in vitro.
The in-vitro efficacy of commercially available topical antimicrobial products against control strains and those from clinical material are compared with an agar diffusion model. The MICs of the constituent antimicrobial compounds have been determined for the same organisms. Plotting the inhibition zone diameters produced by the topical products against the log10 MICs of their constituent antimicrobial compound(s) gives overall product performance profiles for a range of organisms. These profiles confirm that the formulation of a topical product clearly modifies the response obtained with a specific antimicrobial compound.
Hart
A P
AP
Beecham Pharmaceuticals Research Division, Worthing, Sussex, UK.
McColl
K
K
Thomas
C
C
Orr
N A
NA
D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009824:Ointments; D012044:Regression Analysis
D000891:Anti-Infective Agents, Local; D009824:Ointments