[Occupation and urothelial cancer: the background and the clinical figure].
Occupational urothelial carcinomas which were developed by benzidine and beta-naphthylamine have been diagnosed and treated in 60 workers. The number of cases of bladder tumor, ureteral tumor and bladder with upper urinary tract tumor was 49, 2 and 9, respectively. Death from urinary tract carcinoma was 5 (8.3%) and 12 out of 60 died from other diseases, 8 from other organ carcinomas and 4 from none cancer diseases. Organ preserving therapy for occupational urinary tract carcinoma should be selected because of high recurrence tendency, especially cisplatin-radiation or BCG instillation therapy. In future, new candidates will decrease but the fact of the patients becoming older will be important including other organ carcinomas, when we follow them up. Case control study was done by examining replies to questions answered by non-tumor-developing group and tumor developing group. Questions included alcohol, water and cigarette consumption, working duration and difference of chemical substance. A statistically significant result was obtained only in difference of production or messenger of the chemical substance (p = 0.001).
Itatani
H
H
Department of Urology, Sumitomo Hospital.
D015081:2-Naphthylamine / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001560:Benzidines / Q000009:adverse effects*; D016022:Case-Control Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000009:adverse effects*; D009784:Occupational Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology; D012907:Smoking; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000453:epidemiology; D014571:Urologic Neoplasms / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology
D001560:Benzidines; D009281:Naphthalenes; C029876:benzidine; D015081:2-Naphthylamine