title: Distortion products in early stage experimental hydrops in the guinea pig.
abstract: The swelling of the endolymphatic spaces in experimental hydrops is likely to induce mechanical changes all along the cochlea. The selective atrophy of short and middle stereocilia on the outer hair cell above the first cochlear turn is expected to alter micromechanics and transduction. Two tone stimuli were employed in the present study to investigate cochlear distortion products in hydropic ears. Despite a substantial low frequency sensitivity loss on the CAP audiogram, 2f1-f2 distortion products recorded in the RWCM and the CAP were similar in hydropic ears and normal control ears which reflect the probable common origin of these responses--the base of the cochlea where no threshold shifts can be detected. On the other hand this distortion product in the otoacoustic emissions was considerably reduced in hydropic cochleas when the primary tones lay within the pathological part of the audiogram. The reduction of CDT emissions cannot be accounted for by hair cell loss since at the early stage of hydrops described here there is only discrete hair cell loss which is restricted to the apex of the cochlea. On the other hand the reduction in the amplitude of the CDT might reflect disturbance in hair cell function and/or cochlear mechanics above the first cochlear turn.
authors.affiliation: Inserm Unité 229, Laboratoire d'Audiologie Expérimentale, Université de Bordeaux II, France.
authors.forename: K
authors.initials: K
authors.lastname: Horner
authors.forename: Y
authors.initials: Y
authors.lastname: Cazals
mesh_terms: D000200:Action Potentials; D000818:Animals; D001299:Audiometry; D003051:Cochlea / Q000503:physiopathology; D003055:Cochlear Microphonic Potentials; D004487:Edema / Q000503:physiopathology*; D006168:Guinea Pigs; D006309:Hearing / Q000502:physiology*; D010469:Perceptual Distortion / Q000502:physiology*; D013016:Sound