[Preparation of peroral delayed-action drug forms using biological polymers as the base. 4. Preparation of erosion tablets with a base of starch hydrolysis products].
The preparation and investigation of erosonic tablets using a modified starch product are described. Codeine phosphate and pholedrine sulfate served as model drugs. The pharmaceutical investigations showed, that this product is a good auxiliary substance for the direct compression. When in contact with water, the tablets form a gel. This gel determines the drug release. In in vitro investigations a degradation of the starch product by enzymes was detected. Especially the amount of the release values obtained were analyzed by the equation of Noyes-Whitney.
Mank
R
R
Sektion Chemie Wissenschaftsbereich Pharmazie, Humboldt-Universität zu Berlin.
Kala
H
H
Lorenz
A
A
D003061:Codeine / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D006868:Hydrolysis; D008694:Methamphetamine / Q000008:administration & dosage / Q000031:analogs & derivatives; D013213:Starch; D013607:Tablets
D003692:Delayed-Action Preparations; D013607:Tablets; D008694:Methamphetamine; D013213:Starch; C005877:pholedrine; D003061:Codeine
Darstellung peroraler Retardarzneiformen auf der Basis von biologisch abbaubaren Polymeren. 4. Mitteilung: Darstellung von Erosionstabletten auf der Basis eines Stärkehydrolyseproduktes.