title: Exacerbation of metastatic disease shortly after administration of tamoxifen in ER negative advanced breast carcinoma. A case report.
abstract: In a patient with long untreated slow-growing osteoblastic bone metastases from an ER/PgR negative breast carcinoma, new metastatic sites in many lymphnodes pleura and massively in liver have been observed 4 weeks after receiving tamoxifen. Cause-effect relationship between administration of the drug and this unusually rapid spreading of the disease may be considered only as a hypothesis, as it is based wholly on clinical outcome. However, reporting of any exacerbation of breast cancer apparently induced by tamoxifen, even if only anecdotal, is advisable.
authors.affiliation: Medical Oncology Service, Ospedale Maggiore, Parma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cocconi
authors.forename: C
authors.initials: C
authors.lastname: Boni
authors.forename: N
authors.initials: N
authors.lastname: Naldi
authors.forename: R
authors.initials: R
authors.lastname: Nizzoli
authors.forename: C
authors.initials: C
authors.lastname: Bozzetti
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000556:secondary; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000556:secondary; D013629:Tamoxifen / Q000009:adverse effects*
chemical_list: D011960:Receptors, Estrogen; D013629:Tamoxifen