[Synthesis of CSD and it's antitumor effect].
Synthesis of a new polyamine inhibitor dicyclohexylamine sulfonyl chloride (CSD), the structural identification of the synthetic product, and the animal experimental results of it's antitumor effects are reported. Mice bearing leukemia P388 and Ehrlich ascites carcinoma treated with CSD at doses of 50-100 mg/kg p.o. could prolong the survival time of tumor bearing animals. CSD could significantly inhibit spermidine synthesis in vivo. The inhibition was positively correlated to it's antitumor effect, indicating that the antitumor mechanism of CSD is by blocking spermidine synthesis.
Chen
Z Z
ZZ
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
D000818:Animals; D000970:Antineoplastic Agents; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D007941:Leukemia P388 / Q000188:drug therapy; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D011073:Polyamines / Q000037:antagonists & inhibitors
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011073:Polyamines