title: Testosterone therapy in Klinefelter's syndrome (a prolonged observation).
abstract: Clinical observations and pituitary gonadal hormone data was gathered in six patients with Klinefelter's Syndrome during a prolonged period of time. The secondary sex characteristics increased and the gynecomastia generally disappeared. Personality changes were also noted. In half of the patients, the abnormal level of luteinizing and follicular stimulating hormone remained elevated. An enlarged sella turcica was discovered in one patient. It is concluded that testosterone therapy is beneficial in all patients with Klinefelter's Syndrome.
authors.affiliation: Department of Social and Health Services, Mary Bridge Child, Health Center, Tacoma, WA.
authors.forename: R H
authors.initials: RH
authors.lastname: Ruvalcaba
mesh_terms: D000293:Adolescent; D000328:Adult; D005500:Follow-Up Studies; D006062:Gonadotropins / Q000097:blood*; D006177:Gynecomastia / Q000188:drug therapy*; D006801:Humans; D007713:Klinefelter Syndrome / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010551:Personality / Q000187:drug effects; D012658:Sella Turcica / Q000473:pathology; D012741:Sexual Maturation / Q000187:drug effects*; D013739:Testosterone / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D006062:Gonadotropins; D013739:Testosterone