[The role of DNA repair processes in the repair of cytogenetic disorders. The participation of slow to repair DNA damage in the repair of cytogenetic disorders].
Caffeine was used to study the kinetics of cytogenetic damages repair in Chinese hamster fibroblasts. Its half-time (90 min) was shown to correlate with that of repair of slowly repaired DNA damages. The caffeine-induced increase in the number of irreparable DNA damages, attributed to inhibition of double-strand break repair, is in a quantitative correlation with the effect of the cytogenetic damage modification.
Zaichkina
S I
SI
Rozanova
O M
OM
Aptikaeva
G F
GF
Ganassi
E E
EE
D000818:Animals; D002875:Chromosomes / Q000528:radiation effects*; D003037:Cobalt Radioisotopes; D006224:Cricetinae; D004249:DNA Damage; D004260:DNA Repair; D005347:Fibroblasts / Q000528:radiation effects; D005720:Gamma Rays; D066298:In Vitro Techniques; D015162:Micronucleus Tests; D011833:Radiation Injuries, Experimental / Q000235:genetics*; D013997:Time Factors
D003037:Cobalt Radioisotopes
Rol' protsessov reparatsii povrezhdeniĭ DNK v reparatsii tsitogeneticheskikh narusheniĭ. Uchastie medlennorepariruemykh povrezhdeniĭ DNK v reparatsii tsitogeneticheskikh narusheniĭ.