title: Transdermal delivery of nicotine in normal human volunteers: a single dose and multiple dose study.
abstract: The absorption of nicotine delivered by a transdermal delivery system (TDS) was investigated in two separate studies, (A) a dose proportionality study and (B) a multiple dose study. In the dose range of 15-60 mg nicotine, the AUC and Cmax values were proportional to the dose. The levels achieved were in the same range as reported in smokers, following absorption from nicotine chewing gum. The TDS used in the present study produced sustained levels of nicotine for 24 h. No significant accumulation of nicotine was evident as a result of multiple dose administration using a 30-mg nicotine patch. Absorption of nicotine from the TDS was 80-90% and the rate of delivery was similar during both studies.
authors.affiliation: Department of Chemistry, Trinity College, Dublin.
authors.forename: Y B
authors.initials: YB
authors.lastname: Bannon
authors.forename: J
authors.initials: J
authors.lastname: Corish
authors.forename: O I
authors.initials: OI
authors.lastname: Corrigan
authors.forename: J G
authors.initials: JG
authors.lastname: Devane
authors.forename: M
authors.initials: M
authors.lastname: Kavanagh
authors.forename: S
authors.initials: S
authors.lastname: Mulligan
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D002638:Chewing Gum; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D006801:Humans; D009538:Nicotine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012016:Reference Values
chemical_list: D002638:Chewing Gum; D009538:Nicotine