Ethanol's effects on auditory thresholds and reaction times during the acquisition of chronic ethanol self-administration in baboons.
Baboons were trained to ingest ethanol at successively higher ethanol concentrations using oral self-administration techniques. Concurrently, animal psychophysical procedures were employed to determine auditory thresholds and reaction times daily. Maximal consumption of ethanol occurred at concentrations of 6-8% (w/v). During the initial period of ethanol self-administration, both auditory reaction times and auditory thresholds became elevated as animals consumed larger amounts of ethanol. For both the threshold and reaction time measures, the degree of elevation was correlated with the amount of ethanol consumed. These correlations decreased, however, with continued ethanol consumption. The elevations in sensory and motor function recovered to near-baseline levels when ethanol was no longer available.
Hienz
R D
RD
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21206.
Brady
J V
JV
Bowers
D A
DA
Ator
N A
NA
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D010215:Papio; D011930:Reaction Time / Q000187:drug effects*; D012646:Self Administration
D000431:Ethanol