Effects of prolonged administration of triazolam on adenosine A1 and A2 receptors in the brain of rats.
Continuous subcutaneous administration of triazolam, a benzodiazepine with short plasma half-life, for 10 days either decreased (31%, 2 mg/day) or increased (15%, 0.5 mg/day) radioligand binding to adenosine A2 receptors in the rat striatum. In a similar manner, we have shown previously that diazepam (5-10 mg/day), a benzodiazepine with a long plasma half-life attenuated radioligand binding to adenosine A2 receptors in the rat striatum by 45-25%.
Hawkins
M
M
Department of Pharmacology, University of Illinois College of Medicine, Chicago 60612.
Hajduk
P
P
O'Connor
S
S
Radulovacki
M
M
Starz
K E
KE
D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011983:Receptors, Purinergic / Q000187:drug effects / Q000378:metabolism*; D014229:Triazolam / Q000494:pharmacology*
D011983:Receptors, Purinergic; D001569:Benzodiazepines; D014229:Triazolam