Autoantibodies against a nuclear 56 kDa protein: a marker for inflammatory muscle disease.
Antibodies to a 56 kDa nuclear protein have been found in the sera of 85% of patients with myositis using an immunoblotting technique. This auto-antibody appears to be relatively disease-specific though more frequently detectable in both adult and childhood onset dermatomyositis. In adult patients with myositis the anti-56 kDa antibody level reflects disease activity. This antibody is thus much more frequently found than previously described disease-specific autoantibodies in patients with myositis such as the Jo-1 antibody, and may represent a useful diagnostic aid in patients with muscle weakness.
Arad-Dann
H
H
Department of Genetics, Hebrew University of Jerusalem, Israel.
Isenberg
D
D
Ovadia
E
E
Shoenfeld
Y
Y
Sperling
J
J
Sperling
R
R
D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood* / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000150:complications / Q000276:immunology*; D015415:Biomarkers; D002461:Cell Line, Transformed; D016009:Chi-Square Distribution; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015151:Immunoblotting; D008297:Male; D008970:Molecular Weight; D009220:Myositis / Q000150:complications / Q000276:immunology*; D009369:Neoplasms / Q000150:complications / Q000276:immunology; D055517:snRNP Core Proteins
D000974:Antibodies, Antinuclear; D001324:Autoantigens; D015415:Biomarkers; D055517:snRNP Core Proteins; D003402:Creatine Kinase