[The effect of ionol on oxidative-reductive processes in the kidney during heat stroke].
Heat stroke was induced in intact rats in a thermal chamber (45 degrees C) and simultaneously a group of animals was subjected to overheating for the same time but was given intraperitoneal injections of ionol (120 mg/kg) for 2 days and 30 minutes before exposure in the chamber. Significant increase of the concentration of intermediates--lactate, pyruvate, malate, glutamate, ammonia--and decrease of the alpha-ketoglutarate content occurred in the renal tissue in animals of both groups. The NAD/NADH ratio in the cytoplasm and mitochondria reduced essentially, to a greater degree in animals given ionol injections. The last named were distinguished by higher survival and lower degree of hyperthermia.
Seferova
R I
RI
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D002952:Citric Acid Cycle / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D006019:Glycolysis / Q000187:drug effects; D006359:Heat Exhaustion / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats
D002084:Butylated Hydroxytoluene
Vliianie ionola na okislitel'no-vosstanovitel'nye protsessy v pochke pri teplovom udare.