title: Doppler echocardiography: application to the assessment of successful thrombolysis of prosthetic valve thrombosis.
abstract: Prosthetic valve thrombosis remains a significant problem despite anticoagulation therapy and advances in valve design. Thrombolytic therapy offers an alternative approach to valve replacement in patients with high surgical risk. In this article we discuss three cases in which Doppler echocardiography was used to confirm the diagnosis of prosthetic mitral valve obstruction and serially monitor the response of valvular hemodynamic measurements to thrombolysis with intravenous streptokinase. These cases illustrate how the Doppler technique, in addition to allowing the noninvasive diagnosis of prosthetic valve obstruction, is presently the ideal tool to follow serially the effect of thrombolytic therapy on prosthetic valve function.
authors.affiliation: Department of Medicine, Baylor College of Medicine, Houston, TX 77030.
authors.forename: W A
authors.initials: WA
authors.lastname: Zoghbi
authors.forename: R M
authors.initials: RM
authors.lastname: Desir
authors.forename: L
authors.initials: L
authors.lastname: Rosen
authors.forename: G M
authors.initials: GM
authors.lastname: Lawrie
authors.forename: C M
authors.initials: CM
authors.lastname: Pratt
authors.forename: M A
authors.initials: MA
authors.lastname: Quinones
mesh_terms: D000368:Aged; D015150:Echocardiography, Doppler; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D013300:Streptokinase / Q000627:therapeutic use; D013927:Thrombosis / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D013300:Streptokinase