Relation between splenic antibody formation and serum antibody levels to sheep erythrocytes as studied at the level of individual mice.
The relation between splenic antibody formation and serum antibody levels after intraperitoneal immunization of mice with sheep erythrocytes was studied in individual animals. A strong correlation between plaque-forming cell numbers in the spleen and haemolysin and haemagglutinin titres in the serum was observed. These results are at variance with recent data on the development of splenic auto-haemolysin-forming cells and corresponding serum levels after injection of mice with Escherichia coli endotoxin. The background behind the discrepancy between the antigen-driven immune response and the more polyclonal stimulation of B cells with endotoxin is being discussed.
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Eijkman-Winkler Laboratory of Medical Microbiology, Faculty of Medicine, University of Utrecht, The Netherlands.
Hofhuis
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van Dijk
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D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology; D006388:Hemagglutinins / Q000032:analysis; D051379:Mice; D013154:Spleen / Q000276:immunology*
D006388:Hemagglutinins