title: Bone marrow transplantation for familial hemophagocytic lymphohistiocytosis.
abstract: A one year old child diagnosed at two months as having familial hemophagocytic lymphohistiocytosis had a partial response to etoposide. He relapsed and underwent a bone marrow transplant after conditioning with etoposide 65 mg/kg, total body irradiation and cyclophosphamide 60 mg/kg X 2 doses. Post transplant sepsis ensued and the patient expired. At autopsy residual disease was noted. Familial hemophagocytic lymphohistiocytosis continues to be a fatal disorder and etoposide is the only agent known so far with any efficacy. Bone marrow transplantation probably should be attempted early in its course and may have a role in the treatment of this disease.
authors.affiliation: Department of Medicine, New York Medical College, Valhalla.
authors.forename: T
authors.initials: T
authors.lastname: Ahmed
authors.forename: R
authors.initials: R
authors.lastname: Mehta
authors.forename: P
authors.initials: P
authors.lastname: Patel
authors.forename: R
authors.initials: R
authors.lastname: Kaul
authors.forename: A
authors.initials: A
authors.lastname: Kaul
mesh_terms: D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D005047:Etoposide / Q000627:therapeutic use; D015616:Histiocytosis, Non-Langerhans-Cell / Q000188:drug therapy / Q000235:genetics / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D005047:Etoposide