[Biological action of the antiestrogen ICI 164.384 in the MCF-7 mammary cancer cell line].
The biological effects of the anti-estrogen ICI 164.384 on proliferation, on progesterone receptor (PR) and on the conversion of estrone sulfate to estradiol in the MF-7 mammary cancer cells were studied. This anti-estrogen at the low concentration (10(-9)-10(-10) M) blocks cell proliferation and significantly decreases the levels of PR. ICI 164.384 also provokes a very important diminution in the conversion of estrone sulfate to estradiol. It is concluded that the study of the biological responses of this potent anti-estrogen opens new possibilities in the knowledge of the different steps of the mechanism of action of anti-estrogens in mammary cancer cells.
Gelly
C
C
Equipe de Recherche du CNRS n. UA 548, Fondation de Recherche en Hormonologie, Paris, France.
Pasqualini
J R
JR
D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004958:Estradiol / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D004965:Estrogen Antagonists; D004970:Estrone / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D053284:Polyunsaturated Alkamides; D011980:Receptors, Progesterone / Q000378:metabolism; D014407:Tumor Cells, Cultured
D004965:Estrogen Antagonists; D053284:Polyunsaturated Alkamides; D011980:Receptors, Progesterone; D004970:Estrone; D004958:Estradiol; C051781:ICI 164384; D004247:DNA; C017296:estrone sulfate
Action biologique de l'anti-oestrogéne ICI 164.384 dans la lignée cellulaire MCF-7 du cancer mammaire humain.