Sister chromatid exchanges in the human active and inactive X chromosomes.
Four human female fibroblast strains with an i(Xq) or derivative X chromosome as a cytological marker for the inactive X chromosome were used to determine the frequency of sister chromatid exchanges (SCEs) in the active and inactive X chromosomes. No significant difference in SCE frequency between the active and inactive X chromosomes was observed. Therefore, the state of chromatin condensation and the late DNA replication in the facultative heterochromatin of the inactive X chromosome do not appear to influence the SCE frequency.
Zhang
A
A
Department of Pediatrics, Los Angeles County-University of Southern California Medical Center.
Lin
M S
MS
Wilson
M G
MG
Fujimoto
A
A
D002478:Cells, Cultured; D016009:Chi-Square Distribution; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D004247:DNA / Q000096:biosynthesis; D004303:Dosage Compensation, Genetic; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D012854:Sister Chromatid Exchange; D014960:X Chromosome
D005819:Genetic Markers; D004247:DNA