Cerebrospinal fluid penetration after single or multiple dosage with ticarcillin/clavulanate.
Penetration of ticarcillin and clavulanate into the cerebrospinal fluid was studied in ten patients with varying degrees of impairment of the blood-brain barrier. In general, penetration of both drugs was relatively low and variable (5.4 +/- 5.8% for clavulanate and 2.0 +/- 4.0% for ticarcillin) but markedly better in those patients with impaired blood/brain barrier.
Franz
P
P
Neurological Clinic, Ludwig-Maximilians-Universität, München, FRG.
von Rosen
F
F
Garner
C
C
Swozil
U
U
Schmiedek
P
P
Einhäupl
K
K
Adam
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D002969:Clavulanic Acids / Q000008:administration & dosage / Q000134:cerebrospinal fluid*; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000134:cerebrospinal fluid*; D013982:Ticarcillin / Q000008:administration & dosage / Q000134:cerebrospinal fluid*
D002969:Clavulanic Acids; D010406:Penicillins; C043215:ticarcillin-clavulanic acid; D013982:Ticarcillin