Effect of dietary fish oils on the nature of urinary prostaglandin metabolites in rats.
Four different fish oils were compared with sunflower seed oil (SO) and hydrogenated coconut oil (HCO) for their effect on the prostaglandin turnover in vivo in rats, reflected by the mono- and dicarboxylic tetranor prostaglandin metabolites in the urine, measured as tetranor prostane monoic (TPM) and dioic acid (TPD), respectively. Prostaglandin turnover was highest for the animals fed SO and lowest after feeding HCO. Most animals fed fish oil were positioned between the other two oils. The ratio between TPM and TPD, reflecting the ratio between beta and (beta + omega) oxidation, was highest for the animals fed fish oil, intermediate after HCO feeding, and lowest for SO administration. The results clearly indicate that various dietary lipids have different effects on the metabolic pathway of prostanoids. This implies that the level of one single urinary prostanoid metabolite cannot be taken as a measure for the turnover of its parent prostanoid in vivo, unless it has been proven that the treatment under investigation does not affect the metabolic pathway of the prostanoid of interest.
Hornstra
G
G
Department of Biochemistry, Limburg University, Maastricht, The Netherlands.
Stegen
J C
JC
D000818:Animals; D000074263:Coconut Oil; D004041:Dietary Fats / Q000494:pharmacology; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D005395:Fish Oils / Q000494:pharmacology*; D008297:Male; D010938:Plant Oils / Q000494:pharmacology; D011453:Prostaglandins / Q000652:urine*; D051381:Rats; D011919:Rats, Inbred Strains; D000074242:Sunflower Oil
D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D010938:Plant Oils; D011453:Prostaglandins; D000074242:Sunflower Oil; D000074263:Coconut Oil