title: Novel cytocidal antibiotics, glucopiericidinols A1 and A2. Taxonomy, fermentation, isolation, structure elucidation and biological characteristics.
abstract: Two novel antibiotics, glucopiericidinols A1 (1) and A2 (2) were isolated from the cultured broth of Streptomyces sp. OM-5689. The structures of these two compounds were deduced employing spectroscopic analyses. These antibiotics showed potent cytocidal activities against HeLa S3 cells in vitro (MIC 1: 0.39 microgram/ml, 2: 0.10 microgram/ml) when the cells were exposed to the antibiotics for 3 days. Although 1 and 2 showed no activity at 1,000 micrograms/ml against various Gram-positive and Gram-negative bacteria, yeast or fungi, they did have inhibitory activity against Piricularia oryzae (MIC of 1: 125 micrograms/ml, of 2: 31 micrograms/ml).
authors.affiliation: Kitasato Institute, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Funayama
authors.forename: M
authors.initials: M
authors.lastname: Ishibashi
authors.forename: Y
authors.initials: Y
authors.lastname: Anraku
authors.forename: M
authors.initials: M
authors.lastname: Miyauchi
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Komiyama
authors.forename: S
authors.initials: S
authors.lastname: Omura
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000302:isolation & purification*; D013302:Streptomyces / Q000032:analysis
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D011725:Pyridines; C063065:glucopiericidinol A1; C063066:glucopiericidinol A2