Cytotoxic macrolides from a cultured marine dinoflagellate of the genus Amphidinium.
A fourth cytotoxic macrolide, amphidinolide D[1], together with known amphidinolide B[2], has been isolated from a different batch of the cultured dinoflagellate Amphidinium sp., which was symbiotically associated with an Okinawan flatworm Amphiscolops sp. Two-dimensional nmr experiments including 1H-detected heteronuclear multiple-bond correlation (HMBC) resulted in the structure assignment of 1 and structure revision of the diene moiety (C-13-C-15) of amphidinolide B.
Kobayashi
J
J
Mitsubishi Kasei Institute of Life Sciences, Minamiooya, Machida, Tokyo, Japan.
Ishibashi
M
M
Nakamura
H
H
Ohizumi
Y
Y
Yamasu
T
T
Hirata
Y
Y
Sasaki
T
T
Ohta
T
T
Nozoe
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D001643:Bridged Bicyclo Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D004141:Dinoflagellida / Q000032:analysis*; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014407:Tumor Cells, Cultured; D000097442:Amphidinolides
D000970:Antineoplastic Agents; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; C062197:amphidinolide D; D000097442:Amphidinolides