[Indicators of nonspecific immunity in patients with hereditary hemochromatosis].
Parameters of nonspecific defence--complement protein function, circulating immune complex level, neutrophil phagocytic activity, completeness of the phagocytic reaction, C3c level, were evaluated in 162 carriers of hemochromatosis gene (114 homozygotes and 48 heterozygotes with respect to hereditary hemochromatosis) aged from 7 to 64 years. The analysis of the results obtained has permitted a conclusion that the suppression of the complement system function, according to the classic or alternative type, is associated with the disease pathogenesis--hyperferremia, and is caused by the damage of the immunocompetent organs and cells synthesizing individual proteins of the complement, as well as by infectious complications leading to hypocomplementemia with respect to separate components.
Settarova
D A
DA
Vavilova
L M
LM
Tokarev
Iu N
IuN
Golosova
T V
TV
Ku'zmicheva
M Iu
MIu
D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D002648:Child; D003165:Complement System Proteins / Q000172:deficiency / Q000276:immunology; D005260:Female; D005838:Genotype; D006432:Hemochromatosis / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis / Q000276:immunology
D000936:Antigen-Antibody Complex; D003165:Complement System Proteins
Pokazateli nespetsificheskoĭ zashchity u bo'lnykh nasledstvennym gemokhromatozom.