title: Effects of nicotine on gastric contractile response to stimulation of the vagal afferent fibers in cats.
abstract: Effects of nicotine on the delayed gastric contraction due to vagal afferent stimulation were studied. Cats were pretreated with phentolamine (2 mg/kg, i.v.) and propranolol (1 mg/kg, i.v.). The delayed contraction was inhibited by nicotine (100 to 2000 micrograms/kg, i.v.) in a dose-dependent manner. The inhibition of the delayed contraction by nicotine was blocked by hexamethonium (20 mg/kg, i.v.). The results suggested that nicotine inhibits the delayed contraction by activation of hexamethonium-sensitive inhibitory neurons in the vagal pathway to the stomach.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Okamoto
authors.forename: K
authors.initials: K
authors.lastname: Kurahashi
authors.forename: M
authors.initials: M
authors.lastname: Fujiwara
authors.forename: H
authors.initials: H
authors.lastname: Okikawa
mesh_terms: D000818:Animals; D002415:Cats; D005260:Female; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009412:Nerve Fibers / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology*; D009538:Nicotine / Q000494:pharmacology*; D013270:Stomach / Q000502:physiology*; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D006584:Hexamethonium Compounds; D009538:Nicotine