[Detection and determination of acetone using semiconductor sensors].
Investigations to examine not only the factors of influence on evaluation of acetone by self-prepared semiconductor gas sensors, but also to prove analytical properties, were carried out using different tools. A sensor temperature of 600 degrees C and a carrier gas flow-rate of 5 l/h were found to be suitable conditions for the measurement of flow-injection apparatus. The determination of 1 microliter-samples of aqueous solutions containing 1-700 g of acetone/l yielded deviations of 4 to 33%. Using a head space method, the working temperature of 370 degrees C led to a maximum sensor response, the detection limit ranged from 37.5 to 50 mg of acetone/l. After quantifying 5 microliters-sample solutions of 40-600 mg/l, results with an accuracy of 1 to 36% were obtained. The method showed the possibility of distinguishing concentrations of acetone below and above 40 mg/l according to physiological and pathological urinary values. The tests carried out on 100 human urine samples provide a good agreement with the Legal reference method for samples containing physiological or strong pathological amounts of ketone bodies, but not for those including traces and small amounts. False-positive results might be caused by a possible presence of ethanol in urine.
Reichel
J
J
Sektionen Pharmazie, Ernst-Moritz-Arndt-Universität Greifswald.
Seyffarth
T
T
Guth
U
U
Möbius
H H
HH
Göckeritz
D
D
D000096:Acetone / Q000032:analysis* / Q000652:urine; D006801:Humans; D012666:Semiconductors; D013696:Temperature
D000096:Acetone
Untersuchungen zum Nachweis und zur Bestimmung von Aceton mit Halbleitersensoren.