[Changes in glutathione-S-transferase activity under the influence of indirect-action anticoagulants in various types of nutrition].
The experiments on rats showed that the effects of phepromaron and phenylline on glutathione-s-transferase activity in microsomes and cytosol of the liver considerably change due to the character of the diet. The intragastric administration of phepromaron (10 mg/kg) and phenylline (15 mg/kg) on adequate and high fat nutrition 12 hours prior to sacrifice increased the activity of glutathione-s-transferase in microsomes and cytosol. On low protein diet the anticoagulants increased the activity of the enzyme only in cytosol.
Imambaev
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D015110:4-Hydroxycoumarins / Q000494:pharmacology; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D003600:Cytosol / Q000187:drug effects / Q000201:enzymology; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D005982:Glutathione Transferase / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010630:Phenindione / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D015110:4-Hydroxycoumarins; D000925:Anticoagulants; D004041:Dietary Fats; D004044:Dietary Proteins; C004791:phepromaron; D010630:Phenindione; D005982:Glutathione Transferase
Izmenenie aktivnosti glutation-S-transferazy pod vliianiem antikoaguliantov nepriamogo deĭstviia pri raznom kharaktere pitaniia.