title: Effect of adhesive antibiotic TA on plaque and gingivitis in man.
abstract: The adhesive antibiotic TA was applied to the dento-gingival junction of 8 human volunteers, suffering from moderate to severe gingivitis. 2 diametrically opposed quadrants of the mouth received 4 applications of 0.1 mg TA, while the other 2 quadrants were treated with a placebo and served as controls. The plaque index, gingival index and bleeding index were scored periodically for 2 weeks and in 4 patients for up to 30 days. The TA-treated quadrants showed a rapid decrease in all 3 indices following 2 treatments. A further improvement was observed with the 3rd and 4th treatments. 30 days after the onset of the experiment and 23 days after the last application, the indices were still considerably lower than the initial values.
authors.affiliation: Department of Microbiology, George S. Wise, Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Manor
authors.forename: I
authors.initials: I
authors.lastname: Eli
authors.forename: M
authors.initials: M
authors.lastname: Varon
authors.forename: H
authors.initials: H
authors.lastname: Judes
authors.forename: E
authors.initials: E
authors.lastname: Rosenberg
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D004311:Double-Blind Method; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005884:Gingival Hemorrhage / Q000175:diagnosis; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D018942:Macrolides; D010512:Periodontal Index; D010919:Placebos
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D010919:Placebos; C035536:Myxococcus xanthus antibiotic TA