[Immunobiological activity of platinum coordination compounds in a complex with immunoglobulin fragments].
The investigation of biological activity of two coordination platinum (II) compounds covalently linked with Fab-fragments of nonspecific immunoglobulin donors on mononuclears of peripheral man blood in vitro and blood elements of mice BALB/c has been done in this paper. There have been stated the decrease of cytotoxic activity of platinum reagents after complexing and modulating influence of platinum-globulin complexes on immunocompetent cells. The prospects of increasing biological activity of immunological preparations on the basis of directed modification by platinum reagents has been also discussed.
Plotnikov
V M
VM
Kazakov
S A
SA
Merkulov
V G
VG
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000633:toxicity; D001773:Blood Cells / Q000187:drug effects; D002478:Cells, Cultured; D002945:Cisplatin / Q000494:pharmacology* / Q000633:toxicity; D004338:Drug Combinations; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000494:pharmacology / Q000633:toxicity; D000922:Immunotoxins / Q000494:pharmacology* / Q000633:toxicity; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009944:Organoplatinum Compounds / Q000494:pharmacology* / Q000633:toxicity; D010984:Platinum / Q000494:pharmacology* / Q000633:toxicity
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D004338:Drug Combinations; D007140:Immunoglobulin Fab Fragments; D000922:Immunotoxins; D009944:Organoplatinum Compounds; D010984:Platinum; C056870:dichloro(N,N,N',N'-tetrakis(2-aminoethyl)-1,6-hexamethylenediamminediplatinum(II)); D002945:Cisplatin
Immunobiologicheskaia aktivnost' koordinatsionnykh soedineniĭ platiny v komplekse s fragmentami immunoglobulinov.