Steroids and bowel rest versus elemental diet in the treatment of patients with Crohn's disease: the effects on protein metabolism and immune function.
Recent studies have shown an elemental diet to be as effective as bowel rest plus steroids in the management of acute Crohn's disease. In order to investigate the metabolic and immunological effects of these two therapies, six patients with an acute inflammatory attack of ileal Crohn's disease were randomly assigned to receive steroids or elemental diet for 7 days. Immunological and protein metabolic studies were performed before and after therapy, protein kinetic rates being measured by the method of constant intravenous infusion of 14C-labeled leucine tracer. Clinical and symptomatic improvement was noted in all six patients with significant falls in sedimentation rate and platelet counts and increases in albumin concentrations. Both forms of treatment increased plasma amino acid flux and oxidation rates, whole body protein turnover and rates of incorporation of amino acid into albumin. However, the increased rates of protein metabolism in the patients given steroids were at the expense of body protein stores with a net (average) loss of 58 g of nitrogen over 7 days. While both forms of therapy were associated with suppression of lymphocyte subsets, complement and circulating immune complexes only the steroid regimen was associated with suppression of in vivo IgG synthesis rates. The results indicated that both forms of therapy were associated with clinical improvement, increases in protein turnover and evidence of reduced inflammatory activity. However, the beneficial effects of steroid regimen must be balanced against the deleterious effects on body protein stores; steroids and bowel rest without nutritional support should be avoided in malnourished patients.
O'Keefe
S J
SJ
Gastrointestinal Clinic, Groote Schuur Hospital, South Africa.
Ogden
J
J
Rund
J
J
Potter
P
P
D000328:Adult; D000596:Amino Acids / Q000378:metabolism; D003424:Crohn Disease / Q000276:immunology / Q000378:metabolism / Q000628:therapy*; D005526:Food, Formulated; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D007109:Immunity; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D013217:Starvation
D000596:Amino Acids; D011506:Proteins; D009584:Nitrogen; D006854:Hydrocortisone