title: [The effect of neomycin on the contractile activity of the skeletal muscles in the frog].
abstract: Neomycin, a selective inhibitor of the phosphoinositide metabolism, depending on its concentration and the incubation time, depressed the K+-contractures and contractions of m. sartorius R. ridibunda caused by a single or a tetanic electrostimulation. In the experiments on m. rectus abdominis, neomycin inhibited the Ach- and oubaine contractures but not the K+ ones. The contractures of both muscles induced with caffeine did not change in presence of the above antibiotic. The data obtained suggest a participation of phosphoinositides contractions of skeletal muscles induced by excitation of the plasma membrane.
authors.forename: M P
authors.initials: MP
authors.lastname: Danilenko
authors.forename: A D
authors.initials: AD
authors.lastname: Pak
authors.forename: O V
authors.initials: OV
authors.lastname: Esyrev
authors.forename: S N
authors.initials: SN
authors.lastname: Abilova
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004558:Electric Stimulation; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009355:Neomycin / Q000494:pharmacology*; D010042:Ouabain / Q000494:pharmacology; D011895:Rana ridibunda; D013997:Time Factors
chemical_list: D002110:Caffeine; D010042:Ouabain; D009355:Neomycin; D000109:Acetylcholine
vernacular_title: Vliianie neomitsina na sokratitel'nuiu aktivnost' skeletnykh myshts liagushki.