The effects of noncollagenous matrix proteins on hydroxyapatite formation and proliferation in a collagen gel system.
The effects of several noncollagenous matrix proteins on hydroxyapatite formation and growth were studied in a dynamic collagen gel system. In this system growth plate proteoglycan aggregates at concentrations of 1-10 micrograms/ml were effective inhibitors, desulfated aggregates from brachymorphic mice were less effective. Phosphophoryn at 1-100 micrograms/ml had no effect on formation; 60-120 micrograms/ml retarded mineral growth. Type X collagen at concentrations of 50-300 micrograms/ml had no effect on formation or growth.
Boskey
A
A
Hospital for Special Surgery, New York, NY.
Maresca
M
M
Appel
J
J
D002113:Calcification, Physiologic / Q000502:physiology; D003094:Collagen / Q000502:physiology; D005782:Gels; D006882:Hydroxyapatites / Q000378:metabolism*; D010750:Phosphoproteins / Q000502:physiology; D011506:Proteins / Q000502:physiology*; D011509:Proteoglycans / Q000502:physiology
D005782:Gels; D006882:Hydroxyapatites; D010750:Phosphoproteins; D011506:Proteins; D011509:Proteoglycans; C017630:phosphophoryn; D003094:Collagen