title: The effect of detomidine hydrochloride on the electrical activity of uterus in pregnant mares.
abstract: The effect of detomidine on the electrical activity of the uterus was studied during the last trimester of pregnancy in 6 mares. The effect was observed in 3-5 min after the i.m. injection and it lasted for 50-70 min. 20 and 40 micrograms/kg b.w. doses of detomidine decreased the myometrial electrical activity, whereas 60 micrograms/kg dose did not have any effect on the activity. The results suggested that 20, 40 and 60 micrograms/kg b.w. doses of detomidine can be administered to mares during the last trimester of pregnancy without the risk of abortion induced by increased uterine electrical activity.
authors.forename: J
authors.initials: J
authors.lastname: Jedruch
authors.forename: Z
authors.initials: Z
authors.lastname: Gajewski
authors.forename: J
authors.initials: J
authors.lastname: Kuussaari
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004576:Electromyography / Q000662:veterinary; D005260:Female; D006736:Horses / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects* / Q000502:physiology
chemical_list: D000700:Analgesics; D006993:Hypnotics and Sedatives; D007093:Imidazoles; C041255:detomidine