[Effect of hemodialysate and its peptide fractions on stromal cells and heme synthesis in the bone marrow culture and on the activity of selected enzymes and GSH level in human erythrocytes.VI. Effect on GSH level in the erythrocytes of healthy persons and in patients with terminal renal failure].
The purpose of study was in evaluation of the hemodialysate and its peptide fractions on the reduced glutathione++ (GSH) concentration in erythrocytes from healthy subjects and patients with terminal renal insufficiency treated by repeated hemodialyses. Erythrocytes rom dialysed patients' showed statistically significant decrease of the GSH concentration--1.69 +/- 0.28 mmol/l when compared with that in erythrocytes from healthy subjects--2.45 +/- 0.57 mmol/l. In search of factor decreasing the GSH concentration the erythrocytes from healthy subjects and from patients studied were incubated in vitro with the hemodialysate and its peptide fractions. After the 3 hours lasting incubation no significant alterations in the GSH concentration were noted both in erythrocytes from healthy subjects and the patients.
Smoleński
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D003470:Culture Media; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005978:Glutathione / Q000097:blood* / Q000172:deficiency; D006801:Humans; D066298:In Vitro Techniques; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D010446:Peptide Fragments / Q000494:pharmacology*; D012016:Reference Values; D006435:Renal Dialysis; D013727:Terminal Care
D003470:Culture Media; D010446:Peptide Fragments; D005978:Glutathione
Wpływ hemodializatu i jego frakcji peptydowych na komórki podścieliska i synteze hemu w hodowli szpiku oraz na aktywność wybranych enzymów i stezenie GSH w krwinkach czerwonych człowieka. Cześć VI: Wpływ na stezenie GSH w erytrocytach ludzi zdrowych i chorych w schyłkowej niewydolności nerek.