[The effect of the calcium antagonist nifedipine on stress-induced bronchial asthma].
Studies of the efficiency of the calcium antagonist nifedepine on the exercise-induced asthma bronchiale (EIA) were carried out in 15 cases of asthmatics (11 men, 5 women; average age 28.5 years; average time of illness 6.4 years). Duration of exercise was 6 minutes at 80-85% of the maximal age related heart frequency, either on the bicycle ergometer or free running. Rtot, TGV, MEF50, MEF25 and arterial pO2 were measured, Rtot and TGV with air breathing as well as with He/O2 (80% He, 20% O2). Nifedepine reduces significantly the exercise-induced obstruction of the large and the peripheral airways. Possible mechanisms are discussed. Prophylactic treatment with nifedepine is possible. The development of a selective calcium antagonist is desirable.
Mohorn
M
M
Klinik für Innere Medizin, Bereiches Medizin der Friedrich-Schiller-Universität, Jena.
Knüpfer
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000403:Airway Resistance / Q000187:drug effects*; D001249:Asthma / Q000188:drug therapy*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood
D009543:Nifedipine; D010100:Oxygen
Die Wirkung des Calciumantagonisten Nifedipin auf das belastungsbedingte Asthma bronchiale.