title: Glottic and cervical tracheal narrowing in patients with obstructive sleep apnea.
abstract: There are several studies showing that patients with idiopathic obstructive sleep apnea (OSA) have a narrow and collapsible pharynx that may predispose them to repeated upper airway occlusions during sleep. We hypothesized that this structural abnormality may also extend to the glottic and tracheal region. Consequently, we measured pharyngeal (Aph), glottic (Agl), cervical tracheal (Atr1), midtracheal (Atr2), and distal (Atr3) tracheal areas during tidal breathing in 66 patients with OSA (16 nonobese and 50 obese) and 8 nonapneic controls. We found that Aph, Agl, and Atr1, but not Atr2 or Atr3, were significantly smaller in the OSA group than in the control group. Obese patients with OSA had the smallest upper airway area, although the nonapneic controls had the largest areas. Multiple linear regression analysis revealed that the pharyngeal area, cervical tracheal area, and body mass index were all independent determinants of the apnea-hypopnea index, accounting for 31% of the variability in apnea-hypopnea index. Aph, Agl, and Atr showed significant correlation with the body mass index. We conclude that sleep-disordered breathing is associated with diffuse upper airway narrowing and that obesity contributes to this narrowing. Furthermore, we speculate that a common pathophysiological mechanism may be responsible for this reduction in upper airway area extending from the pharynx to the proximal trachea.
authors.affiliation: Department of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.
authors.forename: I
authors.initials: I
authors.lastname: Rubinstein
authors.forename: T D
authors.initials: TD
authors.lastname: Bradley
authors.forename: N
authors.initials: N
authors.lastname: Zamel
authors.forename: V
authors.initials: V
authors.lastname: Hoffstein
mesh_terms: D000328:Adult; D005931:Glottis / Q000503:physiopathology*; D006801:Humans; D007829:Laryngostenosis / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D012891:Sleep Apnea Syndromes / Q000209:etiology* / Q000503:physiopathology; D014133:Tracheal Diseases / Q000150:complications* / Q000503:physiopathology