[The characteristics of the F1 hybrids of spontaneously hypertensive and normotensive rats].
The F1 hybrids between SHR and WKY rats develop borderline hypertension and may be used as a model for the study of interaction of hereditary and environmental factors in the development of hypertension. In order to characterize this model, arterial pressure level, body mass and some behavioral features were studied in the SHR, WKY rats and in two types of their reciprocal F1 hybrids. The arterial pressure level of the F1 hybrids was clove to limits of the borderline hypertension and to midparental level. F1 hybrids differ from normotensive controls in their behavioral activity and in salt appetite. These peculiarities may be related to an enhanced sensitivity of F1 rats to stresses and to salt loads. No essential reciprocal or sex differences were found in the character of inheritance of the features under study. Therefore both types of reciprocal F1 hybrids and both sexes of hybrid animals may be used as a model of the borderline hypertension.
Bachmanov
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D000818:Animals; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D006824:Hybridization, Genetic / Q000235:genetics / Q000502:physiology*; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D011921:Rats, Inbred WKY / Q000502:physiology*
Kharakteristika gibridov F1 spontanno gipertenzivnykh i normotenzivnykh krys.