Glucocorticoid receptors and dissociation constant (Kd) are decreased in mononuclear leukocytes of spontaneously hypertensive rats (SHR-SP) as compared to normotensive Wistar-Kyoto rats (WKY).
We were able to show that spontaneously hypertensive stroke-prone rats (SHR-SP) have a lower number of glucocorticoid receptors (P-value is of borderline significance, 0.01 greater than P less than 0.05) with a highly significant lower Kd (P less than 0.0005), i.e higher affinity in their mononuclear leukocytes, compared to normotensive Wistar-Kyoto rats (WKY). The plasma levels of corticosterone, aldosterone and 18-hydroxycorticosterone of the two strains do not differ.
Laux
M
M
Pharmakologisches Institut, Universität Heidelberg, West Germany.
Bauer
H
H
Ganten
U
U
Zimmerman
F
F
Vecsei
P
P
D015069:18-Hydroxycorticosterone / Q000097:blood; D000450:Aldosterone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood; D005260:Female; D006973:Hypertension / Q000097:blood*; D007700:Kinetics; D009000:Monocytes / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D013045:Species Specificity
D011965:Receptors, Glucocorticoid; D000450:Aldosterone; D015069:18-Hydroxycorticosterone; D003345:Corticosterone