title: Novel 5-substituted 3-(2-naphthalenyl)-3-(1H-imidazol-l-ylmethy)-2-methylisoxazolidine derivatives.
abstract: The synthesis and antifungal activity of a series of novel 5-substituted 3-(2-naphthalenyl)-3-(1H-imidazol-1-ylmethyl)-2- methylisoxazolidine derivatives are described. When tested in vitro in solid agar assays, some of the compounds demonstrated moderate to potent activity against Trichophyton rubrum and Candida albicans.
authors.affiliation: Department of Organic Chemistry, Fisons Pharmaceuticals, Rochester, NY.
authors.forename: G A
authors.initials: GA
authors.lastname: Bennett
authors.forename: G B
authors.initials: GB
authors.lastname: Mullen
authors.forename: S D
authors.initials: SD
authors.lastname: Allen
authors.forename: J T
authors.initials: JT
authors.lastname: Mitchell
authors.forename: V
authors.initials: V
authors.lastname: St Georgiev
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005658:Fungi / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology; D010080:Oxazoles / Q000138:chemical synthesis*
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D007555:Isoxazoles; D009281:Naphthalenes; D010080:Oxazoles