[Effect of altered hormonal balance in the mother-fetus system on body weight, the adrenal glands, thymus gland and peripheral blood leukocyte composition in the offspring].
Pregnant rats have been injected intramuscularly with hydrocortisone-acetate or desoxycorticosterone-acetate (DOCA) for the III or the II-III trimesters of pregnancy. In the last case the animals are given not only greater doses of the hormones, but during a longer period. By the end of the pregnancy the drug dose decreases. In mother-rats after hydrocortisone injections the adrenals mass increases; after DOCA the body mass increases, and that of the adrenals drops. In the offspring hydrocortisone produces decline of the thymus and adrenals mass, as well as neutrophilic leucocytosis, lympho-, eosino-++- and monocytopenia. Just the opposite, DOCA results in lympho- and monocytosis, in increasing morphofunctional activity of monocytes. Common effects in hormonal action is demonstrated as underdevelopment of the adrenals, in decreasing thymus mass, in development of neutrophilic leucocytosis and eosinopenia. With increasing doses and duration of prenatal injections of corticosteroids in rats the mass of the adrenals and thymus drops even greater, stimulating effect of the hormones on the neutrophilic granulocytopoiesis decreases.
Pavlova
I G
IG
D000311:Adrenal Glands / Q000033:anatomy & histology / Q000187:drug effects*; D000818:Animals; D000831:Animals, Newborn / Q000033:anatomy & histology* / Q000097:blood; D001835:Body Weight / Q000187:drug effects*; D003900:Desoxycorticosterone / Q000008:administration & dosage*; D005260:Female; D005333:Fetus / Q000033:anatomy & histology / Q000187:drug effects*; D006854:Hydrocortisone / Q000008:administration & dosage*; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D013950:Thymus Gland / Q000033:anatomy & histology / Q000187:drug effects*
D003900:Desoxycorticosterone; D006854:Hydrocortisone
Vliianie izmenennogo gormona'lnogo fona v sisteme ma't-plod na massu tela, nadpochechnikov, timusa i na leĭkotsitarnyĭ sostav perifericheskoĭ krovi u potomstva.