Human interleukin 2 (IL 2) receptor beta chain allows transduction of IL 2-induced proliferation signal(s) in a murine cell line.
Interleukin 2 (IL 2) delivers cell growth signal by virtue of its interaction with the high-affinity receptor complex, which consists of two distinct IL 2-binding molecules: the IL 2 receptor alpha (IL 2R alpha) and beta (IL 2R beta) chains. Unlike many known growth factor receptors, neither of the IL 2R chains seems to contain a tyrosine kinase domain. In this report, we have shown that the human IL 2R beta chain expressed in a murine IL 3-dependent, non-lymphoid cell line can transduce IL 2-induced cell proliferation signal(s) in combination with the autologous mouse IL 2R alpha chain. This observation should provide a tool to dissect IL 2-induced signal transduction pathway in lymphoid and non-lymphoid cells.
Doi
T
T
Institute for Molecular and Cellular Biology, Osaka University, Japan.
Hatakeyama
M
M
Minamoto
S
S
Kono
T
T
Mori
H
H
Taniguchi
T
T
D000818:Animals; D015152:Blotting, Northern; D015870:Gene Expression; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D007377:Interleukin-3 / Q000494:pharmacology; D008213:Lymphocyte Activation; D046911:Macromolecular Substances; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics; D015375:Receptors, Interleukin-2 / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins; D015398:Signal Transduction; D013045:Species Specificity; D013329:Structure-Activity Relationship; D014162:Transfection
D007376:Interleukin-2; D007377:Interleukin-3; D046911:Macromolecular Substances; D012333:RNA, Messenger; D015375:Receptors, Interleukin-2; D011994:Recombinant Proteins