A screening method using tissue culture for evaluation of potential retinal adhesives.
Several adhesives have been tested for their potentially toxic effects on embryonic retinal tissue. The authors have characterized the effects of the adhesives on neurofilament extension and also on surgical-wound "re-knitting." While none of the adhesives in the sample (including those in current surgical use) seem to be ideal, the model advanced has application for the continuing development of better 'bio-adhesives'. The most immediate application is within the field of vitreoretinal surgery in situations where conventional procedures currently seem inadequate.
Jaffe
M J
MJ
Neuropsychiatry Branch, National Institute of Mental Health, Washington, DC.
Oliver
A P
AP
Von Fricken
M A
MA
Silberstein
L
L
Wyatt
R J
RJ
D000818:Animals; D003094:Collagen / Q000633:toxicity; D046508:Culture Techniques; D004338:Drug Combinations / Q000633:toxicity; D004659:Enbucrilate / Q000633:toxicity; D005340:Fibrinogen / Q000633:toxicity; D007797:Laminin / Q000633:toxicity; D008565:Membrane Proteins / Q000633:toxicity; D008722:Methods; D011509:Proteoglycans / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000187:drug effects*; D014014:Tissue Adhesives / Q000633:toxicity*
C056580:Cell-Tak; D004338:Drug Combinations; D007797:Laminin; D008565:Membrane Proteins; D011509:Proteoglycans; D014014:Tissue Adhesives; C059485:matrigel; D005340:Fibrinogen; D003094:Collagen; D004659:Enbucrilate