title: Non-secretion of ABO blood group antigens: a host factor predisposing to recurrent urinary tract infections and renal scarring.
abstract: In a study of 718 women referred for specialist investigation for recurrent urinary tract infections, 250 (34.8%, P less than 0.01) were non-secretors. The proportion of non-secretors among the women with renal scars (42.6%) was higher than that found for women with no evidence of renal scars (36.6%). Among 29 patients in whom symptoms began in childhood or adolescence, 51.7% were non-secretors. The proportion of non-secretors among individuals with renal scars in this study (42.6%) and that reported in the accompanying paper for Swedish children (40%) suggests that non-secretion might influence the pathogenic sequelae of these infections. Possible host-parasite interactions underlying the increased proportion of non-secretors among women with recurrent urinary tract infections and those leading to development of renal scars are discussed.
authors.affiliation: Department of Bacteriology, Medical School, University of Edinburgh, U.K.
authors.forename: S J
authors.initials: SJ
authors.lastname: May
authors.forename: C C
authors.initials: CC
authors.lastname: Blackwell
authors.forename: R P
authors.initials: RP
authors.lastname: Brettle
authors.forename: C J
authors.initials: CJ
authors.lastname: MacCallum
authors.forename: D M
authors.initials: DM
authors.lastname: Weir
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D002648:Child; D002921:Cicatrix / Q000097:blood* / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007668:Kidney / Q000473:pathology*; D012008:Recurrence; D014552:Urinary Tract Infections / Q000097:blood* / Q000209:etiology / Q000276:immunology
chemical_list: D000017:ABO Blood-Group System; D007070:Immunoglobulin A