[The estrogen receptors of the endometrial plasma membranes in proliferative processes in the postmenopause].
Estradiol receptors of plasma membranes (PM), PM lipids, the activity of membrane-bound enzymes and plasma levels of hormones have been tested in patients of postmenopausal ages with various endometrial diseases (glandular fibrous and glandular cystic polyps, highly, moderately and poorly differentiated adenocarcinomas). Test findings were similar in patients with the glandular cystic polyps and poorly and moderately differentiated adenocarcinomas. Therefore, the patients with the glandular cystic endometrial polyps are at high risk of endometrial cancer. Since the risk increases with higher estrogen plasma levels, the patients with proliferative endometrial conditions may benefit from intake of antiestrogens.
Savel'eva
G M
GM
Sergeev
P V
PV
Breusenko
V G
VG
Mineeva
E N
EN
Kappusheva
L M
LM
D000230:Adenocarcinoma / Q000032:analysis / Q000378:metabolism; D000368:Aged; D002462:Cell Membrane / Q000032:analysis / Q000378:metabolism; D004717:Endometrium / Q000032:analysis* / Q000378:metabolism; D004958:Estradiol / Q000032:analysis / Q000378:metabolism; D005260:Female; D006801:Humans; D008563:Membrane Lipids / Q000032:analysis / Q000378:metabolism; D008593:Menopause / Q000378:metabolism*; D008875:Middle Aged; D011127:Polyps / Q000032:analysis / Q000378:metabolism; D011959:Receptors, Estradiol / Q000032:analysis* / Q000378:metabolism; D014594:Uterine Neoplasms / Q000032:analysis / Q000378:metabolism
D008563:Membrane Lipids; D011959:Receptors, Estradiol; D004958:Estradiol
Retseptory éstrogenov plazmaticheskikh membran éndometriia pri proliferativnykh protsessakh v postmenopauze.