[Effects of dalargin, a synthetic analog of endogenous opioids, on functional indices of isolated rat heart in experimental toxemia in vitro].
The authors studied direct effect of alpha-toxin of Staphylococcus aureus on the main functional indices of isolated perfused heart of intact Wistar rats with the working left ventricle and the ways of pharmacological correction of cardiotoxic lesion of the myocardium in vitro. It was established that alpha-toxin produced a dose-dependent effect on the functional indices of the isolated rat heart, causing in low concentrations positive inotropic effect and with more high concentrations--inhibition of cardiac activity.
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D000818:Animals; D001427:Bacterial Toxins; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006439:Hemodynamics; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013211:Staphylococcus aureus; D013565:Sympatholytics / Q000494:pharmacology*; D014115:Toxemia / Q000503:physiopathology*
D001427:Bacterial Toxins; D013565:Sympatholytics; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie sinteticheskogo analoga éndogennykh opioidov delargina na funktsional'nye pokazateli izolirovannogo serdtsa krysy pri éksperimental'noĭ toksinemii in vitro.