title: The synthetic DNA duplex of poly d(Abr5U).poly d(Abr5U) adopts an A-DNA-like structure.
abstract: An X-ray fiber diffraction study of the synthetic DNA duplex poly d(Abr5U).poly d(Abr5U) shows that its sodium salt adopts an unexceptional A-DNA-like structure. Similar to A-DNA, two molecules are packed in a monoclinic unit cell (a = 2.23 nm, b = 4.14 nm, c = 5.61 nm and alpha = beta = gamma = 90 degrees) of space group C2. Because of its dinucleotide chemical motif, the c-repeat is twice that in A-DNA but, notably, corresponding backbone conformation angles of adjacent nucleotides are almost identical. This is in marked contrast to many B-like conformations of polydinucleotides.
authors.affiliation: Whistler Center for Carbohydrate Research, Purdue University, West Lafayette, Indiana 47907.
authors.forename: R
authors.initials: R
authors.lastname: Chandrasekaran
authors.forename: L C
authors.initials: LC
authors.lastname: Puigjaner
authors.forename: S
authors.initials: S
authors.lastname: Arnott
authors.forename: R G
authors.initials: RG
authors.lastname: He
authors.forename: S
authors.initials: S
authors.lastname: Brahms
authors.forename: J
authors.initials: J
authors.lastname: Brahms
mesh_terms: D003460:Crystallization; D004247:DNA; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011089:Polydeoxyribonucleotides; D014961:X-Ray Diffraction
chemical_list: D011089:Polydeoxyribonucleotides; C062990:polyd(Abr5U).polyd(Abr5U); D004247:DNA