title: Protriptyline treatment of sleep hypoxaemia in Duchenne muscular dystrophy.
abstract: Protriptyline 20 mg daily reduced the total time spent in rapid eye movement sleep in an open study in four subjects with Duchenne muscular dystrophy. Sleep related hypoxaemia and episodes of desaturation were reduced. Anticholinergic side effects were prominent, however, in these patients, precluding its use for regular treatment.
authors.affiliation: Muscle Research Centre, University Department of Medicine, Fazakerley Hospital, Liverpool.
authors.forename: P E
authors.initials: PE
authors.lastname: Smith
authors.forename: R H
authors.initials: RH
authors.lastname: Edwards
authors.forename: P M
authors.initials: PM
authors.lastname: Calverley
mesh_terms: D000293:Adolescent; D000328:Adult; D003986:Dibenzocycloheptenes / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy* / Q000209:etiology; D009136:Muscular Dystrophies / Q000150:complications*; D011530:Protriptyline / Q000627:therapeutic use*; D012895:Sleep, REM / Q000187:drug effects
chemical_list: D003986:Dibenzocycloheptenes; D011530:Protriptyline