title: Embryonic retinal grafts have a beneficial effect on the damaged host retina.
abstract: The adult rat retina was evaluated following surgical lesion and after transplantation of embryonic day 15 (E15) retinal tissue. While a surgical incision caused degeneration and ganglion cell death peripheral to lesion site, the addition of an embryonic retinal implant to the lesion site resulted in a reduction of this degenerative response. In addition, the embryonic graft also exerted a stimulatory effect in the central direction from the lesion site, as increases in layer thicknesses were seen. We speculate that putative diffusable factor(s) may mediate these effects.
authors.affiliation: Department of Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
authors.forename: T W
authors.initials: TW
authors.lastname: Laedtke
authors.forename: J E
authors.initials: JE
authors.lastname: Turner
mesh_terms: D000818:Animals; D002452:Cell Count; D004622:Embryo, Mammalian; D008297:Male; D009414:Nerve Growth Factors / Q000378:metabolism*; D009416:Nerve Regeneration; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000378:metabolism / Q000502:physiology / Q000637:transplantation*
chemical_list: D009414:Nerve Growth Factors