[The synthesis and pharmacological activities of analogs of erycibe alkaloid II].
The C2 deoxy and C6 electron isosteric analogs of a new antiglaucoma agent, erycibe alkaloid II, were designed and synthesized. The main pharmacological results were as follows: 1. The C2-OH in erycibe alkaloid II was one of the key groups for its myotic activity; 2. It was worth noting that compounds 2 and 4 showed cholinergic and anticholinergic activities, respectively. This phenomenon in tropane alkaloids was not reported before; 3. The C6 electron isosteric compounds 16 and 17 showed neither anticholinergic nor cholinergic activities.
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D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D006168:Guinea Pigs; D051379:Mice; D008916:Miotics / Q000138:chemical synthesis*; D010276:Parasympatholytics / Q000138:chemical synthesis*; D010277:Parasympathomimetics / Q000138:chemical synthesis*; D014326:Tropanes
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; D008916:Miotics; D010276:Parasympatholytics; D010277:Parasympathomimetics; D014326:Tropanes; C027863:bao gong teng A