Histidyl proline diketopiperazine (Cyclo [His-Pro]) in eating disorders.
The authors explored the role of Cyclo [His-Pro] (CHP) in 50 adolescents who fulfilled DSM III diagnostic criteria for anorexia nervosa and bulimia. CHP, a relatively new neuro modulator which has a role in inducing satiety, was assayed in serum during routine blood work. CHP levels correlated significantly with weight in restrictor (AN-R) (R = -0.449, P less than 0.05) and bulimic anorexics (AN-B) (R = +0.489, P less than 0.01). There was no significant correlation in normal-weight bulimics (NWB) (R = +0.556, P less than 0.01). It did not correlate with weight in a depressed control group. Longitudinal data on six patients showed a similar relationship between weight, purging and CHP binge/purge activity and/or weight changes of around 2 kilograms correlated with average CHP changes of 42%. Clinical material suggests changes in satiety during CHP changes consistent with a satiety disturbance model of these disorders.
Steiner
H
H
Stanford University School of Medicine, Division of Child Psychiatry and Child Development, CA 94305.
Wilber
J F
JF
Prasad
C
C
Rogers
D
D
Rosenkranz
R T
RT
D000293:Adolescent; D000856:Anorexia Nervosa / Q000097:blood / Q000523:psychology; D001835:Body Weight; D002032:Bulimia / Q000097:blood / Q000523:psychology; D001068:Feeding and Eating Disorders / Q000097:blood* / Q000523:psychology; D005260:Female; D006801:Humans; D010456:Peptides, Cyclic / Q000097:blood*; D010879:Piperazines / Q000097:blood*; D012527:Satiation / Q000502:physiology; D013997:Time Factors
D010456:Peptides, Cyclic; D010879:Piperazines; C015924:histidyl-proline diketopiperazine