Kinetics of a heterogeneous population of particles in low density lipoprotein apolipoprotein B.
This paper examines the kinetics of low density lipoprotein (LDL) metabolism following the in vivo injection of native and chemically-modified lipoproteins in an attempt to assess the relative importance of receptor-dependent and receptor-independent catabolic pathways. The shape of the urinary/plasma ratio curve suggested heterogeneity of the LDL-apolipoprotein B pool and excluded homogeneity. This heterogeneity required the building of a more complex model that allowed the simultaneous fitting of plasma and urinary data. This new model permits the precise quantification of both receptor and non-receptor pathways.
Malmendier
C L
CL
Fondation de Recherche sur l'Athérosclérose, Brussels, Belgium.
Delcroix
C
C
Lontie
J F
JF
D000328:Adult; D001055:Apolipoproteins B / Q000378:metabolism*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008077:Lipoproteins, LDL / Q000378:metabolism* / Q000493:pharmacokinetics; D008297:Male; D008954:Models, Biological; D011973:Receptors, LDL / Q000378:metabolism*
D001055:Apolipoproteins B; D007457:Iodine Radioisotopes; D008077:Lipoproteins, LDL; D011973:Receptors, LDL