The effect of gastronomical concentrations of ethanol on therapeutic effect of cimetidine and sucralfate in rats with chronic gastric ulcers.
Chronic peptic ulcers were produced in the glandular part of the stomach by electrocoagulation of gastric mucosa. Drugs: cimetidine (200 mg/kg) and sucralfate (1000 mg/kg) were given intragastrically once daily for 10 or 20 days, together with ethanol, which was given in a daily dose of 1.8 g/kg, as a 5, 15 or 45% solution. The diluted, 5% ethanol did not impair the healing process either in untreated, or cimetidine- or sucralfate-treated rats. Higher concentrations, 15 and 45%, inhibited healing of the ulcers, particularly the drug-assisted healing process. The 45% ethanol solution after 20 days of administration together with cimetidine or sucralfate completely abolished the therapeutic effect of those drugs in rats with chronic peptic ulcers.
Małecki
I
I
Department of Pharmacology, Institute of Pharmaceutic Industry, Warszawa, Poland.
Borkowska
B
B
D000818:Animals; D002908:Chronic Disease; D002927:Cimetidine / Q000627:therapeutic use*; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013312:Stress, Physiological / Q000150:complications; D013392:Sucralfate / Q000627:therapeutic use*
D000431:Ethanol; D013392:Sucralfate; D002927:Cimetidine