title: The effect of gastronomical concentrations of ethanol on therapeutic effect of cimetidine and sucralfate in rats with chronic gastric ulcers.
abstract: Chronic peptic ulcers were produced in the glandular part of the stomach by electrocoagulation of gastric mucosa. Drugs: cimetidine (200 mg/kg) and sucralfate (1000 mg/kg) were given intragastrically once daily for 10 or 20 days, together with ethanol, which was given in a daily dose of 1.8 g/kg, as a 5, 15 or 45% solution. The diluted, 5% ethanol did not impair the healing process either in untreated, or cimetidine- or sucralfate-treated rats. Higher concentrations, 15 and 45%, inhibited healing of the ulcers, particularly the drug-assisted healing process. The 45% ethanol solution after 20 days of administration together with cimetidine or sucralfate completely abolished the therapeutic effect of those drugs in rats with chronic peptic ulcers.
authors.affiliation: Department of Pharmacology, Institute of Pharmaceutic Industry, Warszawa, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Małecki
authors.forename: B
authors.initials: B
authors.lastname: Borkowska
mesh_terms: D000818:Animals; D002908:Chronic Disease; D002927:Cimetidine / Q000627:therapeutic use*; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013312:Stress, Physiological / Q000150:complications; D013392:Sucralfate / Q000627:therapeutic use*
chemical_list: D000431:Ethanol; D013392:Sucralfate; D002927:Cimetidine