[Determination of the release of drugs from transdermal therapeutic systems. Presentation of a new release system].
A relatively simple release model for transdermal therapeutic systems (TTS) is described. The TTS is separated from the elution solvent by a semipermeable membrane. The elution solvent passes an elution channel with a flow rate of 3-9 ml/h. For the quantitative determination of the drug HPLC or UV spectrometry are used. Depending on the active drug and the design of the TTS, different releasing kinetics are observed. While diclofenac follows approximately a zero order kinetic, the respective kinetic for mepindolol roughly follows a diffusion controlled square root of t-order.
Chen
L S
LS
Institut für Pharmazie und Lebensmittelchemie, Universität Würzburg.
Ebel
S
S
Hoffmann
U
U
Osterwald
H P
HP
D000279:Administration, Cutaneous; D002851:Chromatography, High Pressure Liquid; D004008:Diclofenac / Q000008:administration & dosage; D004058:Diffusion; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008567:Membranes, Artificial; D008954:Models, Biological; D013056:Spectrophotometry, Ultraviolet
D008567:Membranes, Artificial; D004008:Diclofenac
Bestimmung der Freisetzung von Arzneistoffen aus transdermalen therapeutischen Systemen. Vorstellung einer neuartigen Freisetzungsapparatur.