title: The role of induction chemotherapy in inoperable ovarian cancer.
abstract: Thirty patients with bulky advanced ovarian cancer surgically not resectable, received combination chemotherapy (median of 4.1 cycles; range, 3-7) including cisplatin or carboplatin, followed by a second surgical effort. Clinical CR + PR was observed in 24/30 (80%) patients after chemotherapy. Our study deals only with these 24 patients, and the 6 patients who did not respond to chemotherapy are not part of this report. At debulking, 7/24 (29.1%) patients had a complete macroscopic resection; 9/24 (37.5%) patients had a partial resection (residual tumor less than 2 cm). These data suggest that debulking is feasible and successful after chemotherapy containing cisplatin or its derivative. Overall median survival from diagnosis was 18.9 months; the 3-year survival rate was 28%. Median progression-free survival from diagnosis was 13.5 months. The results observed in our study indicate that the use of induction chemotherapy can play an important role in increasing the chances of optimal debulking in patients presenting with unresectable ovarian cancer.
authors.affiliation: Division of Medical Oncology, Ospedale San Giovanni, Torino, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Donadio
authors.forename: G
authors.initials: G
authors.lastname: Bonardi
authors.forename: V
authors.initials: V
authors.lastname: Iberti
authors.forename: O
authors.initials: O
authors.lastname: Bertetto
authors.forename: F
authors.initials: F
authors.lastname: Carnino
authors.forename: L
authors.initials: L
authors.lastname: Iskra
authors.forename: C
authors.initials: C
authors.lastname: Mossetti
authors.forename: A
authors.initials: A
authors.lastname: Calciati
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D012074:Remission Induction