[Relation of estrogen and bone loss in postmenopausal women].
Seventy-six women were divided into three groups: child-bearing age (A), premenopausal (B) and postmenopausal (C). In addition 14 cases were randomly chosen from group C (0-5 years after menopause) for estrogen treatment (5 micrograms ethinylestradiol daily for one month). Serum levels of sex steroids and alkaline phosphatase (ALP) were determined as an index of bone formation. Ratios of fasting urinary calcium to creatinine (Ca/Cr) and of hydroxyproline to creatinine (Hyp/Cr) were taken as indexes of bone resorption. Radial bone mineral content (BMC) was measured by single photon absorptiometry. In group C serum ALP Ca/Cr and Hyp/Cr were increased by 20%, 31% and 33%, and the respective values were reduced by 11%, 33% and 24% after estrogen therapy. In group C there was a significant lowering of radial BMC as well as serum E1 and E2 levels.
Li
X Y
XY
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D015519:Bone Density; D004958:Estradiol / Q000097:blood*; D004970:Estrone / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood*; D011374:Progesterone / Q000097:blood
D004970:Estrone; D011374:Progesterone; D004958:Estradiol; D000469:Alkaline Phosphatase