Nicotine and estrogen metabolism--possible implications of smoking for growth and outcome of treatment of hormone-dependent cancer? Discussion of experimental results.
The combination treatment of hormone-dependent autochthonous mammary carcinomas in the rat with nicotine plus HECNU, a water-soluble nitrosourea, resulted in a potentiation of antitumor action. Nicotine and its metabolite cotinine are strong inhibitors of the aromatase. With regard to investigations in smoking women, suggesting a decreased endogenous estrogen production, our results indicate that smoking might influence growth and treatment results of hormone-dependent human cancer.
Zeller
W J
WJ
Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
Berger
M R
MR
D000818:Animals; D001141:Aromatase / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D004357:Drug Synergism; D004967:Estrogens / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D009538:Nicotine / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D012907:Smoking / Q000378:metabolism*
D004967:Estrogens; D009538:Nicotine; D001141:Aromatase