Hemangioendothelial sarcoma in brown adipose tissue of mouse induced by carcinogenic heterocyclic amine, Glu-P-1.
2-Amino-6-methyldipyrido[1,2-a:3',2'-d]limidazole, a potent bacterial mutagen from glutamic acid pyrolysate, when given to male CDF1 mice at a concentration of 0.05% in the diet induced blood vessel tumors characterized histopathologically. These hemangioendothelial sarcomas showed positive alkaline phosphatase activity histochemically and Weibel-Palade bodies ultrastructurally. Neoplasms were predilective for brown adipose tissue and foci of atypical cells, not peliosis-like lesions, appear to be an early stage in tumor development.
Sakamoto
M
M
National Cancer Center Research Institute, Tokyo, Japan.
Takayama
S
S
Hosoda
Y
Y
D000273:Adipose Tissue / Q000098:blood supply / Q000201:enzymology / Q000473:pathology*; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D006390:Hemangioendothelioma / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D007093:Imidazoles / Q000633:toxicity*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D012039:Regional Blood Flow
D002273:Carcinogens; D007093:Imidazoles; C023785:2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole; D000469:Alkaline Phosphatase