The association of autoimmune disorders with inflammatory bowel disease.
Medical records of patients with ulcerative colitis (n = 858), Crohn's disease (n = 378) and coeliac disease (n = 148) were examined to determine the prevalence of associated autoimmune disorders. Of outpatient controls (n = 300), 2 per cent had at least one autoimmune disorder, compared to 7 per cent with ulcerative colitis, 2 per cent with Crohn's disease and 6 per cent with coeliac disease. Inclusion of primary sclerosing cholangitis with the autoimmune disorders increased the overall prevalence in ulcerative colitis to over 9 per cent. The results provide further indirect evidence of involvement of autoimmune mechanisms in the pathogenesis of ulcerative colitis.
Snook
J A
JA
Gastroenterology Department, Radcliffe Infirmary, Oxford.
de Silva
H J
HJ
Jewell
D P
DP
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications; D001327:Autoimmune Diseases / Q000150:complications*; D002446:Celiac Disease / Q000150:complications*; D015209:Cholangitis, Sclerosing / Q000150:complications; D003093:Colitis, Ulcerative / Q000150:complications*; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence