title: Modification by fentanyl and alfentanil of the intraocular pressure response to suxamethonium and tracheal intubation.
abstract: We have measured in a double-blind study the changes in intraocular pressure (IOP) in 40 consecutive patients (pretreated with fentanyl or alfentanil) who received suxamethonium and tracheal intubation. Although IOP increased significantly following administration of suxamethonium, mean IOP in both groups remained significantly less than control values (P less than 0.002). Tracheal intubation caused a further significant increase in IOP in the fentanyl, but not the alfentanil group. There were no significant differences in mean IOP between the fentanyl and alfentanil groups. Both opioids reduced, but did not abolish the haemodynamic responses to tracheal intubation.
authors.affiliation: Royal Liverpool Hospital.
authors.forename: J
authors.initials: J
authors.lastname: Sweeney
authors.forename: S
authors.initials: S
authors.lastname: Underhill
authors.forename: T
authors.initials: T
authors.lastname: Dowd
authors.forename: S M
authors.initials: SM
authors.lastname: Mostafa
mesh_terms: D000368:Aged; D015760:Alfentanil / Q000627:therapeutic use*; D000768:Anesthesia, General; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007442:Intubation, Intratracheal; D008297:Male; D013508:Ophthalmologic Surgical Procedures; D011292:Premedication; D011897:Random Allocation; D013390:Succinylcholine / Q000009:adverse effects*
chemical_list: D015760:Alfentanil; D013390:Succinylcholine; D005283:Fentanyl