[Studies on the effect of an alkaloid extract of Symphytum officinale on human lymphocyte cultures].
An alkaloid extract of Symphytum officinale was investigated for its chromosome-damaging effect in human lymphocytes in vitro. In concentrations of 1.4 micrograms/ml and 14 micrograms/ml the alkaloids had no effect, in concentrations of 140 micrograms/ml and 1400 micrograms/ml the alkaloids induced sister chromatid exchanges (SCE) as well as chromosome aberrations. Additionally, the influence of rat liver enzymes (S9) was tested. The SCE-inducing capacity and the clastogenic effect of Symphytum alkaloids was increased by simultaneous application of S9-Mix.
Behninger
C
C
Abel
G
G
Röder
E
E
Neuberger
V
V
Göggelmann
W
W
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002875:Chromosomes / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000201:enzymology; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D012854:Sister Chromatid Exchange / Q000187:drug effects
D000470:Alkaloids
Wirkung eines Alkaloidextraktes von Symphytum officinale auf menschliche Lymphocytenkulturen.