title: The effects of a microgravitational environment on the blood pressure maturation curve in normotensive rats.
abstract: In order to determine whether gravity influences the growth of terrestrial mammals, systolic blood pressure, heart rate, urinary output and body weight were measured at 10-day intervals from the age of 30 days (weaning) to 150 days in 12 male Sprague-Dawley rats. Six rats were grown in a gravitational environment. 'Dry' water immersion was used to subject six rats to a microgravitational environment between the ages of 30 and 90 days. A downward shift in systolic blood pressure and body weight maturation curves was observed in the microgravitational group from the age of 60 days. After the 'dry' water immersion was stopped, the fully developed rats showed a significant increase in systolic blood pressure, which returned to control values, but not in body weight. We conclude that the physiological increase in systolic blood pressure taking place in rats during growth is partly dependent on gravity.
authors.affiliation: Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Magrini
authors.forename: M
authors.initials: M
authors.lastname: Ciulla
authors.forename: R
authors.initials: R
authors.lastname: Meazza
authors.forename: P
authors.initials: P
authors.lastname: Reggiani
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D004780:Environment, Controlled; D006112:Gravitation; D006339:Heart Rate / Q000502:physiology; D007101:Immersion / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014556:Urine / Q000502:physiology