Exacerbation of metastatic disease shortly after administration of tamoxifen in ER negative advanced breast carcinoma. A case report.
In a patient with long untreated slow-growing osteoblastic bone metastases from an ER/PgR negative breast carcinoma, new metastatic sites in many lymphnodes pleura and massively in liver have been observed 4 weeks after receiving tamoxifen. Cause-effect relationship between administration of the drug and this unusually rapid spreading of the disease may be considered only as a hypothesis, as it is based wholly on clinical outcome. However, reporting of any exacerbation of breast cancer apparently induced by tamoxifen, even if only anecdotal, is advisable.
Cocconi
G
G
Medical Oncology Service, Ospedale Maggiore, Parma, Italy.
Boni
C
C
Naldi
N
N
Nizzoli
R
R
Bozzetti
C
C
D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000556:secondary; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000556:secondary; D013629:Tamoxifen / Q000009:adverse effects*
D011960:Receptors, Estrogen; D013629:Tamoxifen