[Disorders of cardiac contractile function and myocardial adrenoreactivity during stress depending on the thyroid hormone level].
An effect of the administration of thyroid hormones at small doses (on the one hand) and hypothyroidism (on the other hand) on stress-induced changes of myocardial contractility and adrenoreactivity was studied in experiments on 86 random bred male rats. The use of thyroid hormones at small doses irrespective of a drug form prevents stress-induced decrease of cardiac contractility and preserves a sufficiently high level of myocardial adrenoreactivity. The suppression of thyroid function of the thyroid gland led to a decrease in adrenoreactivity and caused more profound disorder of contractility in stress. All these data suggest that physiological doses of thyroid hormones prevent cardiac contractility disorders and preserve sufficiently high myocardial adrenoreactivity.
Bozhko
A P
AP
Sukhorukova
T A
TA
D000311:Adrenal Glands / Q000187:drug effects / Q000503:physiopathology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D007037:Hypothyroidism / Q000097:blood / Q000503:physiopathology; D008297:Male; D008713:Methimazole / Q000008:administration & dosage; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D013961:Thyroid Gland / Q000187:drug effects / Q000503:physiopathology; D013963:Thyroid Hormones / Q000008:administration & dosage*; D013974:Thyroxine / Q000097:blood
D013963:Thyroid Hormones; D008713:Methimazole; D013974:Thyroxine
Narusheniia sokratitel'noĭ funktsii serdtsa i adrenoreaktivnost' miokarda pri stresse v zavisimosti ot urovnia tireoidnykh gormonov.