title: Indium-111 WBC scan in acute toxic centrilobular hepatic necrosis.
abstract: In this case of prolonged fever and abnormal liver functions, dual tracer scintigraphy with In-111 WBCs and Tc-99m SC led to a biopsy-proven diagnosis of severe acute toxic hepatitis (hepatocellular necrosis). Correlation of the Tc-99m SC scan findings with those previously reported for "pseudotumors" of the liver is discussed. A "pseudonormal" scan pattern is described for the In-111 WBC scintigraphy. Discordance between In-111 WBC and Tc-99m SC scintigraphy in this clinical setting should raise the possibility of hepatic necrosis as a diagnostic alternative to hepatic abscess.
authors.affiliation: Department of Radiology, Baylor College of Medicine, Houston, Texas.
authors.forename: R M
authors.initials: RM
authors.lastname: Davidson
authors.forename: R D
authors.initials: RD
authors.lastname: Dhekne
authors.forename: W H
authors.initials: WH
authors.lastname: Moore
mesh_terms: D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007962:Leukocytes; D008099:Liver / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D007205:Indium Radioisotopes; D013671:Technetium Tc 99m Sulfur Colloid