Effects of nicotine on gastric contractile response to stimulation of the vagal afferent fibers in cats.
Effects of nicotine on the delayed gastric contraction due to vagal afferent stimulation were studied. Cats were pretreated with phentolamine (2 mg/kg, i.v.) and propranolol (1 mg/kg, i.v.). The delayed contraction was inhibited by nicotine (100 to 2000 micrograms/kg, i.v.) in a dose-dependent manner. The inhibition of the delayed contraction by nicotine was blocked by hexamethonium (20 mg/kg, i.v.). The results suggested that nicotine inhibits the delayed contraction by activation of hexamethonium-sensitive inhibitory neurons in the vagal pathway to the stomach.
Okamoto
T
T
Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan.
Kurahashi
K
K
Fujiwara
M
M
Okikawa
H
H
D000818:Animals; D002415:Cats; D005260:Female; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009412:Nerve Fibers / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology*; D009538:Nicotine / Q000494:pharmacology*; D013270:Stomach / Q000502:physiology*; D014630:Vagus Nerve / Q000502:physiology
D006584:Hexamethonium Compounds; D009538:Nicotine