[Effect of diltiazem on the functional activity of erythrocytes and thrombocytes in patients with ischemic heart disease].
The functional activity of erythrocytes and platelets was studied in 50 patients with various types of coronary heart disease. The patients' plasma exhibited higher ADP levels due to erythrocyte microhemolysis and higher platelet malonic dialdehyde and intracellular calcium, which led to enhanced platelet functional activity. Treating the patients with the calcium antagonist diltiazem was found to result in lower ADP and platelet calcium levels whereas the concentrations of malonic dialdehyde remained unchanged.
Razumov
V B
VB
Gutkin
A B
AB
Leonova
M V
MV
Khudiakova
N D
ND
D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors / Q000097:blood; D000328:Adult; D000368:Aged; D002118:Calcium / Q000037:antagonists & inhibitors / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy*; D004110:Diltiazem / Q000627:therapeutic use*; D004912:Erythrocytes / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006461:Hemolysis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology*
D000244:Adenosine Diphosphate; D004110:Diltiazem; D002118:Calcium
Vliianie diltiazema na funktsiona'lnuiu aktivnos't éritrotsitov i trombotsitov u bo'lnykh ishemicheskoĭ bolez'niu serdtsa.