title: Indications for adaptation to differently high vitamin C supplies in guinea pigs. 2. Development of hepatic amounts of microsomal protein and cytochromes (P-450, b5) after altered dosing.
abstract: Guinea pigs longlastingly (6-8 weeks) supplied with 680 mg/100 g vitamin in the food and for ten weeks thereafter exposed to: 5 mg/100 g: show no ability to maintain the amounts of hepatic microsomal cytochrome P-450 20 mg/100 g: show the typical symptom of an evolving adaptation by an overshoot of the amounts of hepatic microsomal cytochrome P-450.
authors.affiliation: Biochemisches Institut der Universität Giessen.
authors.forename: E
authors.initials: E
authors.lastname: Degkwitz
authors.forename: R H
authors.initials: RH
authors.lastname: Bödeker
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D015786:Cytochromes b5 / Q000378:metabolism*; D006168:Guinea Pigs; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*
chemical_list: D011506:Proteins; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D001205:Ascorbic Acid