Systemic interleukin I administration suppresses arachidonic acid-induced ear oedema in the mouse.
Recombinant human interleukin 1 beta (IL-1 beta), given intraperitoneally to mice as a single injection, significantly suppressed the development of arachidonic acid (AA)-induced ear oedema. This effect was noted 2 h after administration and for at least 5 days afterwards. IL-1 beta was effective in the dose range of 250 ng-20 micrograms/mouse. Injection of IL-1 beta per se resulted in erythema of the ears, and thus, IL-1 beta has the capacity not only to induce and augment but also to suppress inflammatory responses. Indomethacin administered as subcutaneously-implanted pellets did not influence the IL-1 beta induced-ear erythema, but suppressed to some extent the effect of IL-1 beta on the AA-induced ear oedema.
Bäck
O
O
E.I. du Pont de Nemours and Co., Glenolden, PA 19036.
Newton
R C
RC
Huang
J J
JJ
Linna
T J
TJ
D000818:Animals; D001095:Arachidonic Acids; D004306:Dose-Response Relationship, Immunologic; D004427:Ear Diseases / Q000139:chemically induced / Q000188:drug therapy*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors
D001095:Arachidonic Acids; D007213:Indomethacin