[Comparison of effect in the change of respiration by stimulating three trigeminal subnucleus].
Experiments were performed on 31 rabbits. After recovery from surgical anesthesia the change of respiration were observed in various experimental conditions, under which original nucleus of trigemini (ONT), terminal nucleus of trigemini (TNT), spinal tractus nucleus of trigemini (SNT) were respectively stimulated by an electrical current (EC) or monosodium glutamate (MSG) or lidocaine (LID). Because SNT had a longitudinal long shape, three different sections of SNT were selected as stimulating points respectively, namely rostral point (A2.33 mm), middle point (AP0 mm) and caudal point P1.9 mm). Phrenic nerve discharge and its integrated curve, PCO2 and blood pressure were recorded by a RM-6000 polygraph. The results indicated that the stimulations of EC and MSG to SNT and TNT enhanced respiratory activity obviously. Stimulation of EC and MSG to ONT caused much less enhancement of respiration. Microinjection of LID to TNT and ONT decreased respiratory activity, but microinjection of LID to SNT increased. The present experiment concluded that stimulation of SNT and TNT could cause significant change in respiration.
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D000818:Animals; D004558:Electric Stimulation; D008012:Lidocaine / Q000494:pharmacology; D011817:Rabbits; D012119:Respiration / Q000502:physiology*; D014278:Trigeminal Nuclei / Q000502:physiology*
D008012:Lidocaine