Pharmacokinetics of propofol in young children after a single dose.
The pharmacokinetics of propofol were studied following a single bolus injection (2.5 mg kg-1) in 10 healthy children (4-7 yr). Propofol was distributed rapidly and extensively (Vss 10.9 (1.2) litre kg-1) and cleared rapidly from the body (Cl 30.6 (2.9) ml min-1 kg-1). With the exception of a larger central compartment volume (V alpha 722 (113) ml kg-1), these data are similar to those reported for young adults who received an identical dose and who underwent sampling over the same period. The larger value of V alpha is consistent with the higher induction dose requirement reported for children.
Saint-Maurice
C
C
Département d'Anesthésie-Réanimation, Hôpital Saint-Vincent-de-Paul, Paris, France.
Cockshott
I D
ID
Douglas
E J
EJ
Richard
M O
MO
Harmey
J L
JL
D002648:Child; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D015742:Propofol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D015742:Propofol