[New research on muscular function: NMR spectroscopy. Application to malignant hyperthermia].
P31 nuclear magnetic resonance spectroscopy (NMRS) is a new noninvasive method for the study of normal and diseased muscle. Significant differences between the spectra of normal and pathological human muscles were reported in some known myopathies and in patients with congestive heart failure. The possibility that metabolic disturbances are linked to contraction abnormalities led to the investigation of malignant hyperthermia susceptible (MHs) muscle with NMRS. At rest, no differences were found between patients and normal subjects. During exercise, and recovery, MHs exercise hyperthermic patients developed an abnormal P31 spectral configuration, indicating a defective energy metabolism. This technique is of great interest, and could be used in patients with muscle diseases of unknown origin. NMRS with P31 and, simultaneously, other nuclei (C13, H1) could refine the results already obtained.
Kozak-Reiss
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Centre de Résonance Magnétique Biologique et Médicale, CNRS UA 1186, Faculté de Médecine, Marseille.
D004198:Disease Susceptibility; D004734:Energy Metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008305:Malignant Hyperthermia / Q000175:diagnosis*; D009119:Muscle Contraction; D009126:Muscle Relaxation; D009132:Muscles / Q000473:pathology / Q000502:physiology*; D009135:Muscular Diseases / Q000175:diagnosis*; D010725:Phosphocreatine / Q000032:analysis; D010758:Phosphorus
D010725:Phosphocreatine; D010758:Phosphorus
Nouvelles explorations de la fonction musculaire: spectroscopie RMN. Application à l'hyperthermie maligne.