title: [Hepatocyte necrosis and intrahepatic cholestasis in the postoperative period of patients undergoing heart surgery with the use of extracorporeal circulation: significance of clinical, epidemiologic, surgical and laboratory parameters in evaluating prognosis].
abstract: Sixteen patients with jaundice after heart surgery with extracorporeal circulation, were studied. They were divided in 2 groups, according to the postoperative outcome; either death (group I) or hospital discharge (group II). Clinical, epidemiological, surgical and laboratorial aspects were compared in order to ascertain their role in the outcome. The results were analysed by the Student-t test. The main cause of death was low output syndrome, which occurred in 10 cases (62.5%), 5 of them died (31%). A statistically significant difference was observed in the postoperative values of serum GOT (p less than 0.01), GPT (p less than 0.01) and total bilirubin (p less than 0.01), which were then considered prognostic indicators in these patients.
authors.affiliation: Serviço de Fígado do Hospital da Beneficência Portuguesa de São Paulo.
authors.forename: A
authors.initials: A
authors.lastname: de Oliveira e Silva
authors.forename: L A
authors.initials: LA
authors.lastname: D'Albuquerque
authors.forename: L F
authors.initials: LF
authors.lastname: Roldan Molina
authors.forename: T E
authors.initials: TE
authors.lastname: dos Santos
authors.forename: J de M
authors.initials: Jde M
authors.lastname: Gurgel
authors.forename: G C
authors.initials: GC
authors.lastname: Santo
authors.forename: T
authors.initials: T
authors.lastname: Genzini
authors.forename: A A
authors.initials: AA
authors.lastname: de Carvalho
authors.forename: J J
authors.initials: JJ
authors.lastname: Gama-Rodrigues
mesh_terms: D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002780:Cholestasis, Intrahepatic / Q000209:etiology*; D005112:Extracorporeal Circulation; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000209:etiology; D011183:Postoperative Complications; D011379:Prognosis
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin
vernacular_title: Necrose hepatocitária e colestase intrahepática no pós-operatório de pacientes submetidos à cirurgia cardíaca com o emprego de circulação extracorpórea: importância dos parâmetros clínicos, epidemiológicos, operatórios e laboratoriais na avaliação do prognóstico.