Effects of artemether on peripheral T, B, T mu and T gamma lymphocytes in beagle dog.
The effects of intramuscular injection of Artemether on peripheral T, B, T mu and T gamma lymphocytes in beagle dogs was investigated cytochemically. Doses used were 6, 19, and 32 MKD, respectively. Results showed that after injection of Artemether for 15 successive days, the T, B, and T mu lymphocytes of the 19 and 32 MKD groups were markedly reduced and the T gamma lymphocytes of all 3 dosage groups were decreased to zero. 28 days after cessation of the drug, T, T mu and T gamma lymphocytes had recovered to control levels, while the B lymphocytes of the 19 and 32 MKD groups remained markedly lower than those of the control groups. The differences and similarities of the effects on the peripheral T, B, T mu and T gamma lymphocytes produced by the 3 dosages of Artemether and the relationship between the changes of T, B lymphocytes and immunological function of beagle dogs are discussed.
Gu
Y X
YX
Cui
Y F
YF
Wu
B A
BA
Shi
X C
XC
Teng
X H
XH
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D000077549:Artemether; D037621:Artemisinins; D001402:B-Lymphocytes / Q000187:drug effects*; D004285:Dogs; D005260:Female; D008297:Male; D012717:Sesquiterpenes / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; D000077549:Artemether