title: The renal effects of kainic acid.
abstract: The effect of kainic acid (KA), a potent neurotoxic agent, on the renal function of rats was investigated. Intrahippocampal and intraperitoneal KA injections (2.5 micrograms and 8 mg/kg, respectively) led to a decrease in glomerular filtration rate and U/P inulin ratio with a concomitant increase in the amount of excreted Na+. However, acid excretion was maintained. These findings support the idea of a straight connection between neurohormonal secretion and renal function and may provide an interesting model to study renal hemodynamic changes induced by neurological disturbances.
authors.affiliation: Departamento de Fisiologia, Escola Paulista de Medicina, São Paulo, Brasil.
authors.forename: F Z
authors.initials: FZ
authors.lastname: Gil
authors.forename: V L
authors.initials: VL
authors.lastname: Costa-Silva
authors.forename: M F
authors.initials: MF
authors.lastname: Cavanal
authors.forename: D
authors.initials: D
authors.lastname: Amado
authors.forename: E A
authors.initials: EA
authors.lastname: Cavalheiro
mesh_terms: D000138:Acidosis / Q000139:chemically induced*; D000818:Animals; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007444:Inulin / Q000378:metabolism; D007608:Kainic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D051381:Rats; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D012964:Sodium / Q000378:metabolism
chemical_list: D007444:Inulin; D012964:Sodium; D007608:Kainic Acid