Colorado IDDM Registry: lower incidence of IDDM in Hispanics. Comparison of disease characteristics and care patterns in biethnic population.
The Colorado IDDM Registry identifies newly diagnosed cases of insulin-dependent diabetes mellitus (IDDM) throughout the state. Hispanics in Colorado are a racial mixture of American Indian and White populations. Because American Indians have a low risk of IDDM, and differing frequencies of HLA antigens and haplotypes are reported for Hispanics and non-Hispanics, we compared incidence rates and disease characteristics. Eligible participants were less than 18 yr of age and Colorado residents at time of diagnosis, diagnosed between 1 January 1978 and 31 December 1983, and on insulin within 2 wk of diagnosis. Subjects were reported by their physicians, and statewide validation of reporting was conducted through review of hospital discharge indexes. Incidence rates for Hispanics (n = 76) were significantly lower than those for non-Hispanics (n = 628), although 95% confidence intervals overlapped for children aged 10-17 yr. Age-adjusted rates were significantly lower in Hispanic than non-Hispanic males, whereas age-adjusted rates for females did not differ. The cumulative risk of IDDM was less for Hispanic males aged 0-17 yr than for non-Hispanic males (P less than .001); cumulative risk among females was males (P less than .001); cumulative risk among females was not different (P = .10). Clinical onset characteristics and medical care at diagnosis were similar. After diagnosis, hospitalizations per 100 person-yr appeared higher in Hispanics, but ketoacidosis and insulin reactions per 100 person-yr were similar. Difference in rate of hospitalizations may have been due to lower response rates among older non-Hispanics.(ABSTRACT TRUNCATED AT 250 WORDS)
Gay
E C
EC
Department of Preventive Medicine, University of Colorado School of Medicine, Denver 80262.
Hamman
R F
RF
Carosone-Link
P J
PJ
Lezotte
D C
DC
Cook
M
M
Stroheker
R
R
Klingensmith
G
G
Chase
H P
HP
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003120:Colorado; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000453:epidemiology*; D005006:Ethnicity; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D012042:Registries; D012737:Sex Factors; D011795:Surveys and Questionnaires