DOI is a mixed agonist-antagonist at postjunctional 5-HT2 receptors in the pithed rat.
The maximal pressor effect induced by DOI in the pithed rat was smaller than that induced by 5-HT, suggesting partial agonistic properties of DOI. DOI shifted the dose-pressor response curve of 5-HT to the right. It is concluded that, in addition to its 5-HT2 agonistic properties, DOI also possesses 5-HT2 antagonistic properties in the pithed rat.
Dabiré
H
H
INSERM U 228, Faculté de Médecine Broussais Hôtel-Dieu, Paris, France.
Chaouche-Teyara
K
K
Cherqui
C
C
Fournier
B
B
Schmitt
H
H
D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003655:Decerebrate State; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists
D000662:Amphetamines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine