[The effect of the administration of slow releasing type of dipyridamole on teflon graft patency for experimental superior vena cava replacement in mongrel dogs].
Teflon graft tubes (10 mm in diameter, 20-25 mm in length) were implanted in 40 mongrel dogs for replacement of the superior vena cava and were followed 12 days to 6 months after the operation. In these, 22 dogs in Group I were given a slow releasing type of dipyridamole (10 mg/kg, daily) and 18 dogs in the other group were not given for the control study. The results were compared in each group. The medicated group showed much less rate of graft thrombosis 2/22 (9.1%) vs. 9/18 (50%), less rate of intimal hyperplasia 2/22 (9.1%) vs. 18/18 (100%) and also less rate of graft obstruction 1/22 (4.5%) vs. 9/18 (50%). These findings demonstrated that the medicated group can expect highly significant (p less than 0.01) superior patency of the graft with dipyridamole in macroscopic findings. Also, microscopic and electron microscopic findings showed much more smooth healing of the surface of the graft. We concluded that postoperative administration of a slow releasing type of dipyridamole may be effective for smooth endothelialization of Teflon graft used as the experimental superior vena cava replacement.
Hasegawa
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Hasegawa
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D000818:Animals; D001807:Blood Vessel Prosthesis; D003692:Delayed-Action Preparations; D004176:Dipyridamole / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D011138:Polytetrafluoroethylene; D014654:Vascular Patency / Q000187:drug effects*; D014683:Vena Cava, Superior / Q000601:surgery*
D003692:Delayed-Action Preparations; D004176:Dipyridamole; D011138:Polytetrafluoroethylene