title: [Motor complications in patients with Parkinson disease treated with levodopa].
abstract: Motor complications appearing in 180 patients with Parkinson's disease who received levodopa for a long period are reviewed. The most frequently observed motor disorders were wearing off fluctuations and dyskinesias of "dose benefit". Most patients who presented a decrease in the response to levodopa developed signs during the course or findings in complementary tests which were incompatible with the diagnosis of Parkinson's disease. In the present study, the duration of the treatment with levodopa and the duration of the disease varied in parallel in such a way that it was not possible to individualize the relative importance of both factors in the development of the observed motor complications.
authors.forename: M R
authors.initials: MR
authors.lastname: Luquin
authors.forename: J A
authors.initials: JA
authors.lastname: Obeso
authors.forename: J M
authors.initials: JM
authors.lastname: Martínez-Lage
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004409:Dyskinesia, Drug-Induced / Q000150:complications / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D013997:Time Factors
chemical_list: D007980:Levodopa
vernacular_title: Complicaciones motoras en pacientes con enfermedad de Parkinson tratados con levodopa.