Effect of hepatic artery ligation on liver metabolism in rats.
The rat is an experimental model of orthotopic liver transplant that does not need arterial revascularization of the transplanted liver. The objective of the present study was to investigate the effect of hepatic artery ligation on hepatic metabolism in rats. After 2, 3 or 24 h of hepatic artery ligation, no significant differences in serum levels of alanine aminotransferase were observed. Bile flow decreased significantly 3 h after arterial ligation (P less than 0.05) and returned to normal after 24 h (P less than 0.05).
Gonçalves
R H
RH
Departamento de Cirurgia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
Castro-e-Silva Júnior
O
O
Franco
C F
CF
Souza
M E
ME
Picinato
M A
MA
Mazzetto
S A
SA
Ceneviva
R
R
D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001646:Bile / Q000032:analysis*; D006499:Hepatic Artery / Q000601:surgery*; D008099:Liver / Q000502:physiology*; D008102:Liver Circulation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000410:Alanine Transaminase