title: In vitro immunologic features of Weimaraner dogs with neutrophil abnormalities and recurrent infections.
abstract: In vitro evaluation of cellular and humoral immunity in Weimaraner dogs with recurrent infections and abnormal neutrophil function revealed significantly lower serum immunoglobulin (Ig) G and M concentrations than control dogs. Lymphocyte blastogenesis in response to three different mitogens, interleukin-1 and -2 production, natural killer (NK) cell activity, and in vitro IgG and IgM production were similar to those of control dogs.
authors.affiliation: Department of Veterinary Clinical Sciences, Ohio State University, Columbus 43210.
authors.forename: C G
authors.initials: CG
authors.lastname: Couto
authors.forename: S
authors.initials: S
authors.lastname: Krakowka
authors.forename: G
authors.initials: G
authors.lastname: Johnson
authors.forename: P
authors.initials: P
authors.lastname: Ciekot
authors.forename: R
authors.initials: R
authors.lastname: Hill
authors.forename: L
authors.initials: L
authors.lastname: Lafrado
authors.forename: G
authors.initials: G
authors.lastname: Kociba
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000662:veterinary*; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D017099:IgG Deficiency; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000172:deficiency; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000662:veterinary*; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D009504:Neutrophils / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007375:Interleukin-1; D007376:Interleukin-2