title: Autosomal dominant retinitis pigmentosa (ADRP): localization of an ADRP gene to the long arm of chromosome 3.
abstract: Members of a large pedigree of Irish origin presenting with early onset Type I autosomal dominant retinitis pigmentosa (ADRP) have been typed for D3S47 (C17), a polymorphic marker from the long arm of chromosome 3. Significant, tight linkage of ADRP to D3S47, with a lod score of 14.7 maximizing at 0.00 recombination, has been obtained, hence localizing the ADRP gene (RP1) segregating in this pedigree to 3q.
authors.affiliation: Department of Genetics, Trinity College Dublin, Ireland.
authors.forename: P
authors.initials: P
authors.lastname: McWilliam
authors.forename: G J
authors.initials: GJ
authors.lastname: Farrar
authors.forename: P
authors.initials: P
authors.lastname: Kenna
authors.forename: D G
authors.initials: DG
authors.lastname: Bradley
authors.forename: M M
authors.initials: MM
authors.lastname: Humphries
authors.forename: E M
authors.initials: EM
authors.lastname: Sharp
authors.forename: D J
authors.initials: DJ
authors.lastname: McConnell
authors.forename: M
authors.initials: M
authors.lastname: Lawler
authors.forename: D
authors.initials: D
authors.lastname: Sheils
authors.forename: C
authors.initials: C
authors.lastname: Ryan
mesh_terms: D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D012174:Retinitis Pigmentosa / Q000235:genetics*
chemical_list: D005819:Genetic Markers