title: [Effect of verapamil on hepatorenal toxicity induced by cyclosporin].
abstract: The immunosuppressive and nephrotoxic effects of cyclosporine A (CsA) have been ascribed to a calcium-dependent mechanism of action. However, verapamil, a slow-calcium-channel blocking agent, enhances the immunosuppressive action of CsA and reduces its nephrotoxicity. The present experimental study performed in Wistar rats demonstrates that 0.1 mg..24 h.-1 IM verapamil prevents reduction of liver weight caused by treatment with 20 mg..kg.-1..24 h.-1 IM, as well as a rise in SGOT, SGPT, serum LDH and creatinine. The nephro-protective effects of verapamil in rats treated with CsA could be ascribable to the increased plasma clearance of the immunosuppressive agent.
authors.forename: M A
authors.initials: MA
authors.lastname: Aller Reyero
authors.forename: J
authors.initials: J
authors.lastname: Arias Pérez
authors.forename: L
authors.initials: L
authors.lastname: Lorente Ruigómez
authors.forename: L
authors.initials: L
authors.lastname: Arias Fernández
authors.forename: J I
authors.initials: JI
authors.lastname: Trovo Muñiz
authors.forename: D
authors.initials: D
authors.lastname: Brandau Ballnet
authors.forename: H
authors.initials: H
authors.lastname: Durán Sacristán
mesh_terms: D000818:Animals; D003524:Cyclosporins / Q000633:toxicity*; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D003524:Cyclosporins; D014700:Verapamil
vernacular_title: Efecto de verapamil sobre la toxicidad hepatorrenal inducida por ciclosporina.