[The effect of local administration of recombinant interleukin-2 (rIL-2) on metastatic gastric tumor: report of an autopsy case].
The case is reported in which local administration of recombinant interleukin-2 (rIL-2) was successfully performed. A 54 year-old female who was operated on for advanced gastric cancer 15 years ago suffered from dyspnea and swelling of left anterior cervical lymph nodes. The histological examination of the cervical lymph node biopsied and cytological finding of pleural effusion confirmed the metastasis of adenocarcinoma. 11 x 10(6) unit of rIL-2 (S6820, Shionogi) per day was administered into the pleural cavity 8 times per month and this therapy was successful in decreasing a amount of pleural effusion. Simultaneously the number of tumor cells in pleural effusion was diminished, the CEA level in pleural effusion were also decreased and the LAK activities of prepared lymphocyte from pleural effusion were augmented. 6.5 x 10(6) unit of rIL-2 was also administered per day locally into the left anterior cervical lymph nodes 13 times per month and induced the decrease of lymph node swelling. A slight fever which can be controlled with antipyretic agent easily was only symptom after local administration of rIL-2. Besides the success of these treatment, the general condition gradually deteriorated. She died 6 month after admission. The autopsy revealed that only one anterior cervical lymph node was slightly enlarged and there is a few tumor cells in the lymphatic sinus. No other lymph node was found around the cervical area. There are a prominent pleural fibrous adhesion including only a few tumor cells infiltrated. These findings strongly indicated the clinical usefulness of local administration of rIL-2.
Takahashi
H
H
Zeniya
M
M
Ohkoshi
H
H
Kameda
H
H
Matsumoto
I
I
Furusato
M
M
Aizawa
S
S
D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000627:therapeutic use*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000188:drug therapy*
D007376:Interleukin-2; D011994:Recombinant Proteins