Effects of intraventricularly applied gangliosides and N-acetylneuraminic acid on acquisition and retention performance of a brightness discrimination task in rats.
The effects of intraventricularly applied gangliosides (about 90 to 120 nmoles/10 microliters) and N-acetylneuraminic acid (800 nmoles/10 microliters) on acquisition and retention of a brightness discrimination task were studied in rats. Single injection of GT1b and N-acetylneuraminic acid improved the retention performance. GM1 showed an enhancing effect on both acquisition and retention, while GD1a and GD1b exerted no influence on the behavioral parameters tested. The findings presented show how memory may be improved by exogenous application of substances commonly occurring in the mammalian body.
Popov
N
N
Institute of Pharmacology and Toxicology, Medical Academy, Magdeburg, G.D.R.
Toffano
G
G
Riechert
U
U
Matthies
H
H
D000818:Animals; D004193:Discrimination Learning / Q000187:drug effects*; D005732:Gangliosides / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012153:Retention, Psychology / Q000187:drug effects*; D012794:Sialic Acids / Q000494:pharmacology*; D013647:Task Performance and Analysis
D005732:Gangliosides; D012794:Sialic Acids