Vasoactive intestinal peptide: behavioral effects in the rat and hamster.
The behavioral effects of intracerebroventricular (ICV) injection of the brain-gut peptide vasoactive intestinal peptide (VIP) were quantified with a behavioral sampling technique in home-caged, nondeprived, male and female albino rats and golden hamsters. ICV VIP sex-dependently decreased observed resting behavior during 1 hr after injections in both rats and hamsters at 0.1-10.0 micrograms. Grooming behavior was increased in hamsters, and rearing and standing behaviors were increased in rats, sex-dependently at VIP doses that decreased resting. Drinking behavior was suppressed in rats by VIP at 10.0 micrograms. Intraperitoneal (IP) VIP (100.0 micrograms/kg) increased 5% ethanol intake and decreased eating behavior in fluid-deprived male rats. The increase in ethanol intake produced by IP VIP was prevented by IP cholecystokinin octapeptide (CCK, 4.0 micrograms/kg). VIP potently controls resting and ingestive behaviors, suggesting a role for this neuropeptide, along with CCK, in the feedback regulation of rodent behavior.
Kulkosky
P J
PJ
Department of Psychology, University of Southern Colorado, Pueblo 81001-4901.
Doyle
J S
JS
Cook
V I
VI
Glazner
G W
GW
Foderaro
M A
MA
D000428:Alcohol Drinking; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002766:Cholecystokinin / Q000494:pharmacology; D006224:Cricetinae; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D008297:Male; D051381:Rats; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D014660:Vasoactive Intestinal Peptide; D000431:Ethanol; D002766:Cholecystokinin