title: [Diagnosis of minor chromosome modifications by molecular cytogenetics].
abstract: Chromosomal in situ hybridization with radioactive probes allows the detection of single copy DNA segments of very small size. In two phenotypically normal individuals, classical chromosomal analysis revealed a small partial deletion of chromosome 18 short arm. In situ hybridization of probe D18S3, located at 18p13, showed in both instances a balanced reciprocal translocation: 46,XY,t(5;18) (p153;p112) and 46,XX,t(18;22)(p111;p11), respectively.
authors.affiliation: U.249 INSERM Centre Hospitalier, Montpellier, France.
authors.forename: S
authors.initials: S
authors.lastname: Taviaux
authors.forename: A
authors.initials: A
authors.lastname: Moncla
authors.forename: F
authors.initials: F
authors.lastname: Giraud
authors.forename: J
authors.initials: J
authors.lastname: Demaille
authors.forename: J F
authors.initials: JF
authors.lastname: Mattei
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D002872:Chromosome Deletion; D002887:Chromosomes, Human, Pair 18; D002892:Chromosomes, Human, Pair 22; D002895:Chromosomes, Human, Pair 5; D015342:DNA Probes; D005260:Female; D006801:Humans; D007621:Karyotyping / Q000379:methods*; D009693:Nucleic Acid Hybridization; D010375:Pedigree; D011247:Pregnancy; D014178:Translocation, Genetic
chemical_list: D015342:DNA Probes
vernacular_title: Diagnostic de remaniements chromosomiques de petite taille par la cytogénétique moléculaire.