NMR studies on DNA hairpin structures with a five nucleotide loop.
One- and two-dimensional NMR experiments have been undertaken to investigate the structure of DNA hairpins with a five nucleotide loop. Analysis of proton NMR spectra suggests that the four hairpin structures examined have some common structural features; B-type conformation in the stem region and the same stacking pattern, 5' (XXX-turn-XX) 3', in the loop region. The phosphorus NMR spectra suggest that the conformational changes in the loop region affect the backbone conformation of the stem duplex.
Uesugi
S
S
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Oda
Y
Y
Hiroaki
H
H
Ikehara
M
M
D001483:Base Sequence; D004247:DNA; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation
D004247:DNA