title: [Mechanisms of the effect of obsidan on the clinical picture of myocardial infarction at the early stage of the disease].
abstract: The study of clinical manifestations and cardiodynamics in macrofocal myocardial infarction was conducted a few hours or days since the disease onset. Altogether 36 patients were examined. Obsidan administration was employed in 24 patients, basic indication to its use being clinico-hemodynamic++ signs of sympathetic hyperactivity. Clinical response to the drug was correlated with reactions of neurohumoral adaptation of the acute phase: levels of cyclic AMP, GMP and serotonin. Potentiating effect on obsidan analgesia, resolution of clinical symptoms of sympathetic hypertonus efficient energetic regime of the heart are mediated by activation of stress-limiting systems, i.e. links of cGMP and serotonin mechanisms.
authors.forename: O M
authors.initials: OM
authors.lastname: Andriushchenko
mesh_terms: D000328:Adult; D000368:Aged; D006321:Heart / Q000187:drug effects / Q000294:innervation*; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D011433:Propranolol / Q000627:therapeutic use*; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D011433:Propranolol
vernacular_title: O mekhanizmakh vliianiia obzidana na klinicheskuiu kartinu infarkta miokarda v pervye chasy bolezni.