[Antilithogenic action of dehydroxymaleic, ketomalonic (mesoxalic) and tartronic acids in relation to experimental lithiasis in rats].
The authors study the effects of three acids, one with four carbon atoms, dihydroxymaleic acid, the two others with three carbon considered atoms, ketomalonic acid and tartronic acid. A first study considered the effects of these products on experimental lithiasis induced by oxalic acid, glyoxylic acid and ethylene-glycol. Dihydroxymaleic acid. Monohydrate calcium oxalate stones can be easily induced in the male rat, with in 24 hours, by an intraperitoneal injection of oxalic acid, at the rate of 8 mg per 100 g of body weight. If 25 mg of dihydroxymaleic acid are injected simultaneously via the intraperitoneal route, to a rat weighing 150 g, the lithiasis observed after 24 hours is just as severe. Experimental monohydrate calcium oxalate lithiasis is also induced by intraperitoneal injection of 8 to 9 mg of glyoxylic acid in a 100 mg rat. Dihydroxymaleic acid, injected at the same time as glyoxylic acid, also via the intraperitoneal route, at the rate of 50 mg for a rat weighing 150 g, results in total suppression of the lithiasis. Dihydroxymaleic acid also prevents lithiasis induced by the absorption by the rat, for several weeks, of a 1% ethylene-glycol solution if it is mixed to this solution at the rate of 5 mg per ml. A 12% ethylene-glycol solution given to the rat at the rate of 0.55 ml for 100 g of body weight induces the next day a comatose state and a diffuse parenchymatous monohydrate calcium oxalate lithiasis: coma and lithiasis are prevented by the simultaneous absorption of dihydroxymaleic acid at the rate of 65 to 70 mg. The ketomalonic acid.(ABSTRACT TRUNCATED AT 250 WORDS)
Thomas
J
J
Clinique Urologique de l'Hôpital Cochin, Paris.
Thomas
E
E
Rinjard
P
P
Steg
A
A
D000818:Animals; D005260:Female; D008297:Male; D008298:Maleates / Q000627:therapeutic use*; D008314:Malonates / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013646:Tartronates / Q000627:therapeutic use*; D014545:Urinary Calculi / Q000139:chemically induced / Q000517:prevention & control*
D008298:Maleates; D008314:Malonates; D013646:Tartronates; C032973:tartronic acid; C062975:2,3-dihydroxymaleic acid; C008375:mesoxalic acid
Etudes sur l'action antilithogène des acides dihydroxymaléique, cétomalonique (mésoxalique) et tartronique vis-à-vis de la lithiase expérimentale du rat.