Effects on rats of subacute intoxication with deltamethrin via an osmotic pump.
To explore the possibility of liver enzyme induction by deltamethrin, subacute intoxication was carried out in rats for 28 days, by administration 7.2 mg.Kg-1.day-1 of deltamethrin i.p. delivered by an osmotic pump inserted in the peritoneal cavity. The body weight curve of the treated rats increased slightly but not significantly compared to the controls. No neurotoxic effect was observed. Blood parameters were unchanged, except for eosinophilia and an increase in the plasma Na+ level. Cytochrome P-450, cytochrome b5, NADPH-cytochrome c reductase, esterases and the activities of six mixed function oxidases were assayed. No variation was noted. Ultrastructural study of the liver, more specially in midlobular region, showed that deltamethrin increased the number of mitochondria and altered their shape which became irregular. These findings were consistent with morphometric results. Succinate cytochrome c reductase, citrate synthase and cytochrome c oxidase were essayed, only this last showed a significant enhancement in deltamethrin treated rats.
Catinot
R
R
UDC CNRS-INSERM, UA 400, Université René Descartes, Faculté de Médecine, Paris, France.
Hoellinger
H
H
Pfister
A
A
Sonnier
M
M
Simon
M T
MT
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006403:Hematologic Tests; D007260:Infusion Pumps; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000648:ultrastructure; D008862:Microsomes, Liver / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D009570:Nitriles; D009997:Osmotic Pressure; D011722:Pyrethrins / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000097:blood
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin; D012964:Sodium