Effect of D-galactosamine on blood clearance of 99mTc-phytate in dogs.
The effect of D-galactosamine (GalN) on the blood clearance of 99mTc-phytate (99mTc-P) in dogs was examined, and the blood clearance test of 99mTc-P was compared with the cases of the serum transaminase and bilirubin test. Serum transaminase and bilirubin levels in dogs increased dose-dependently after GalN administration, and the degree of increase in these parameters was much higher than the cases in rats. The disappearance rate of 99mTc-P from blood in dogs decreased with the increase in dose of GalN and with the passage of time after the GalN administration. Changes of the blood clearance of 99mTc-P after GalN treatment in dogs may be influenced by the disorder in the hepatocytes. The blood clearance test of 99mTc-P in dogs showed a sensitive reaction for the acute hepatic dysfunction induced by GalN equally to the serum transaminase and bilirubin test.
Shibata
H
H
Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.
Kohno
M
M
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology; D004285:Dogs; D005260:Female; D005688:Galactosamine / Q000633:toxicity*; D006932:Hyperbilirubinemia / Q000139:chemically induced; D008111:Liver Function Tests; D008297:Male; D015609:Organotechnetium Compounds; D010833:Phytic Acid
D015609:Organotechnetium Compounds; C026177:technetium phytate; D005688:Galactosamine; D010833:Phytic Acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin