[A new model of complete global brain ischemia produced by clamping the ascending aorta with aorta to right-atrium and aorta to femoral vein bypass formation in dogs].
The author made a new model of complete global brain ischemia (CGBI) in dogs, by clamping ascending aorta with aorta to right atrium and aorta to femoral vein bypass formation. In this study, dogs were kept under CGBI for 18 minutes with this method, and their hemodynamic changes and neurologic outcome after ischemia were evaluated. In all dogs, cardiovascular functions were well preserved without any hemodynamic support after CGBI. Although neurologic functions were severely damaged and all dogs were in vegetative state, all of them survived for at least 4 days after ischemia. With this method, it is possible to keep animals under CGBI long enough to cause severe neurologic damages without serious extracerebral complications. I conclude that, to evaluate the efficacy of treatments with neurologic outcome, this is the most appropriate model of complete global brain ischemia in dogs.
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D000818:Animals; D001011:Aorta / Q000601:surgery; D002545:Brain Ischemia; D003250:Constriction; D004195:Disease Models, Animal; D004285:Dogs; D005268:Femoral Vein / Q000601:surgery; D006325:Heart Atria / Q000601:surgery