[Effects of ubinon-9, a synthetic antioxidant, on intensity of lipid peroxidation in blood platelets and plasma of patients with ischemic heart disease].
The antioxidant ubinon-9 was tested for its effects on platelet and plasma lipid peroxidation parameters in patients with acute ischemic heart diseases. The use of ubinon-9 in the multimodality therapy of patients with ischemic heart disease was shown to result in a significant decrease in lipid peroxidation intensity by enhancing superoxide dismutase activity in the platelets and plasma from the patients. Ubinon-9 equally prevented lipid peroxidation activation during enzymatic and nonenzymatic induction in the platelets of patients with unstable angina or acute myocardial infarction. Unlike a daily dose of 30 mg, 90 mg a day is a more effective dose in reducing platelet and plasma lipid peroxidation parameters. One may suggest that addition of ubinon-9 into the routine treatment regimen allows the therapy for acute ischemic heart disease to be optimize.
Shevchenko
I A
IA
Shatilina
L V
LV
Borisenko
L V
LV
Balliuzek
M F
MF
Gurevich
V S
VS
D000328:Adult; D000789:Angina, Unstable / Q000188:drug therapy; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D009930:Organic Chemicals; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D009930:Organic Chemicals; C060091:ubinon; D013482:Superoxide Dismutase
Vliianie sinteticheskogo antioksidanta ubinona-9 na intensivenost' perekisnogo okisleniia lipidov v thrombotsitakh i plazme krovi bol'nykh ishemicheskoĭ bolezn'iu serdtsa.