[Synthesis of pyrazolo[3,4-e][1,4]diazepine-4,7-diones with central nervous system activity].
The synthesis of 1-phenyl-5,8-dimethyl-1,4,5,6,7,8-hexahydro-pyrazolo[3,4-e][1,4] diazepin-4,7-dione and of 1-phenyl-3,5,8-trimethyl-1,4,5,6,7,8-hexahydro-pyrazolo[3,4-e] [1,4]diazepin-4,7-dione is described. These compounds exhibit activity on CNS in animals.
Sprio
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Dipartimento di Chimica e Tecnologie Farmaceutiche, Università di Palermo.
Caronna
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Migliara
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Petruso
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Matera
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D000818:Animals; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology; D001463:Barbiturates / Q000494:pharmacology; D002491:Central Nervous System Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects
D001381:Azepines; D001463:Barbiturates; D002491:Central Nervous System Agents; D011720:Pyrazoles; C062378:1-phenyl-3,5,8-trimethyl-1,4,5,6,7,8-hexahydropyrazolo(3,4-e)(1,4)diazepin-4,7-dione; C062374:1-phenyl-5,8-dimethyl-1,4,5,6,7,8-hexahydropyrazolo(3,4-e)(1,4)diazepin-4,7-dione
Sintesi di derivati pirazolo[3,4-e][1,4]diazepin-4,7-dioni attivi sul sistema nervoso centrale.