title: Histamine turnover in the rat hypothalamic nuclei estimated from alpha-fluoromethylhistidine-induced histamine decrease.
abstract: The turnover rates, rate constants and half-life values of neuronal histamine (HA) in 10 nuclei of the rat hypothalamus were estimated from the depletion of HA induced by alpha-fluoromethylhistidine (alpha-FMH: 100 mg/kg, i.p.), a specific inhibitor of histidine decarboxylase, on the presumption that alpha-FMH depletable HA pools represent neuronal ones. Marked variation in the HA turnover rates were observed among the hypothalamic nuclei, ranging from 5.7 to 19.5 pmole/mg protein/hr.
authors.affiliation: Department of Pharmacology, Okayama University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Itoh
authors.forename: R
authors.initials: R
authors.lastname: Oishi
authors.forename: M
authors.initials: M
authors.lastname: Nishibori
authors.forename: K
authors.initials: K
authors.lastname: Saeki
mesh_terms: D000818:Animals; D006207:Half-Life; D006632:Histamine / Q000378:metabolism*; D006639:Histidine / Q000031:analogs & derivatives*; D007031:Hypothalamus / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008762:Methylhistidines; D051381:Rats
chemical_list: D008762:Methylhistidines; D006639:Histidine; C028309:alpha-fluoromethylhistidine; D006632:Histamine