[Influence of adaptation to stressor effects on bioelectrical activity, contractile function and resistance of the papillary muscles to the excess of intracellular calcium].
In experiments on papillary muscles of rats it was established that adaptation to stressor effects increases resistance of the myocardium to contracture effects and restricts depression of electrophysiological parameters caused by the excess of calcium. Such adaptation decreased contracture by 6.5 times. On the next stage it was established that adaptation restricts depression of electrophysiological parameters of cardiomyocytes with the action of large concentrations of calcium. Possible mechanism of cardiac protector effect of adaptation to stressor effects is being discussed.
Meerson
F Z
FZ
Malyshev
I Iu
IIu
D000222:Adaptation, Physiological; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D008297:Male; D008564:Membrane Potentials; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D010210:Papillary Muscles / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
D002118:Calcium
Vliianie adaptatsii k stressornym vozdeĭstviiam na bioélektricheskuiu aktivnost', sokratitel'nuiu funktsiiu i rezistentnost' papilliarnoĭ myshtsy k izbytku vnutrikletochnogo kal'tsiia.