title: Clinical manifestations and therapy of heat stroke: consumptive coagulopathy successfully treated by exchange transfusion and heparin.
abstract: This report of 8 cases (6 severe and 2 mild) heat stroke patients seen during the hot summer of 1987 at Pramongkutklao Hospital, Bangkok, represent the first report of this syndrome in Thailand. Severe cases presented with deep coma, shock, ARDS, DIC and other systemic complications. Two cases of mild heat stroke recovered completely with conventional treatment. Two of the 6 severe cases died with DIC, bleeding and acute renal failure. The other 4 surviving cases received early exchange transfusion and low dose heparin therapy. The clinical features of these 4 cases were as severe as those recorded for fatal heat stroke patients, including shock over 10 hours in 4, coma longer than 120 hours in 3, ARDS and DIC in 1. From these findings, early exchange transfusion plus low dose heparin should be considered as one effective treatment in severe fatal heat stroke patients.
authors.affiliation: Hematology Division, Pramongkutklao Hospital, College of Medicine, Bangkok, Thailand.
authors.forename: T
authors.initials: T
authors.lastname: Srichaikul
authors.forename: W
authors.initials: W
authors.lastname: Prayoonwiwat
authors.forename: S
authors.initials: S
authors.lastname: Sanguanwong
authors.forename: S
authors.initials: S
authors.lastname: Eawsrikoon
authors.forename: P
authors.initials: P
authors.lastname: Pholvicha
mesh_terms: D004211:Disseminated Intravascular Coagulation / Q000150:complications; D005078:Exchange Transfusion, Whole Blood; D006359:Heat Exhaustion / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D006493:Heparin