title: Immune suppression induced by the brown ear tick Rhipicephalus appendiculatus Neumann, 1901.
abstract: The brown ear tick Rhipicephalus appendiculatus suppressed in vivo and in vitro immune responses in the rabbit. Humoral responses were suppressed during infestation; however, suppression was transient and was unrelated to previous exposure of hosts to similar tick infestations. Immune suppression was caused by putative lymphocytotoxic factor(s) in tick salivary secretions as evidenced by in vitro lymphocytotoxicity assays. In an identical study of Rhipicephalus zambeziensis, a closely related rhipicephalid, the immune response was not suppressed, indicating that immune suppression is not common to the genus Rhipicephalus.
authors.affiliation: Veterinary Research Laboratory, Causeway, Zimbabwe.
authors.forename: B H
authors.initials: BH
authors.lastname: Fivaz
mesh_terms: D000818:Animals; D002470:Cell Survival; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D007108:Immune Tolerance; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000502:physiology; D008297:Male; D011817:Rabbits; D012867:Skin / Q000276:immunology; D013984:Tick Infestations / Q000276:immunology*; D013987:Ticks / Q000276:immunology*