title: Left ventricular function, tricuspid incompetence, and incidence of coronary artery disease late after orthotopic heart transplantation.
abstract: Functional results and data concerning the incidence and severity of graft atherosclerosis (GASC) and tricuspid incompetence (TI) in the intermediate term after orthotopic heart transplantation (HTX) are still striking. We examined 92 patients 1, 2, and 3 years after HTX by right and left heart catheterization in order to evaluate pump function, the status of the coronary arteries and the extend of TI, using a double indicator thermodilation technique. Mean left ventricular volumes and ejection fraction were normal 1 and 2 years post-transplant. The incidence of GASC was 8/87 (9.2%) at 1, and 11/92 (12%) at 2 years. It was more frequent (16%) in patients with preexisting coronary artery disease (IHD) than in patients with underlying dilative cardiomyopathy (DCM) (11%). At the end of the 1st postoperative year, 62% of patients were free of TI, whereas only 38% had normal valve function 2 years posttransplant. In 9/14 (64%) of patients, consecutively assessed at 1 and 2 years, TI had increased between both investigations. Preoperative haemodynamics, the number of endomyocardial biopsies and rejection episodes as well as preoperative cardiac size did not correlate with TI. Left ventricular volumes and ejection fraction are normal in the intermediate term after HTX. The incidence of GASC was less than 10% at 1 year and did not significantly increase thereafter. TI is a frequent and yet unexplained finding after HTX showing a considerable tendency to increase with time, but with little or not haemodynamic consequence.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Hannover Medical School, Federal Republic of Germany.
authors.forename: G
authors.initials: G
authors.lastname: Herrmann
authors.forename: R
authors.initials: R
authors.lastname: Simon
authors.forename: A
authors.initials: A
authors.lastname: Haverich
authors.forename: J
authors.initials: J
authors.lastname: Cremer
authors.forename: L
authors.initials: L
authors.lastname: Dammenhayn
authors.forename: H J
authors.initials: HJ
authors.lastname: Schäfers
authors.forename: T
authors.initials: T
authors.lastname: Wahlers
authors.forename: H G
authors.initials: HG
authors.lastname: Borst
mesh_terms: D000328:Adult; D003324:Coronary Artery Disease / Q000453:epidemiology*; D005260:Female; D006084:Graft Rejection; D016027:Heart Transplantation / Q000009:adverse effects* / Q000502:physiology; D006801:Humans; D015994:Incidence; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology; D011446:Prospective Studies; D012307:Risk Factors; D013318:Stroke Volume / Q000502:physiology; D013997:Time Factors; D014262:Tricuspid Valve Insufficiency / Q000453:epidemiology*