Decrease of ultraviolet-induced DNA injury in human skin by p-aminobenzoic acid esters.
The effect of a sunscreen containing a p-aminobenzoic acid (PABA) ester on ultraviolet-induced DNA injury was assessed on human epidermal cells by the measure of unscheduled DNA synthesis intensity. Our results show that DNA repair was reduced by approximately 50%. Therefore, sunscreens based on PABA esters might be expected to reduce photocarcinogenesis.
De Rijcke
S
S
Department of Dermatology, Hospital Erasme, Free University of Brussels, Belgium.
Heenen
M
M
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D001345:Autoradiography; D004247:DNA / Q000096:biosynthesis*; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D006801:Humans; D012867:Skin / Q000166:cytology / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism; D014466:Ultraviolet Rays / Q000009:adverse effects*
D004247:DNA; D010129:4-Aminobenzoic Acid; D013936:Thymidine