Melatonin administered systemically alters the properties of visual cortex cells in cat: further evidence for a role in visual information processing.
The effects of melatonin given systemically at night-time were investigated in the visual system of cats by means of electrophysiological recordings from single cells in the striate cortex (area 17). Following intravenous injection of melatonin, the spontaneous discharge rate (SDR) was found to decrease in the majority of units when compared to control situations. In addition, the amplitude of responses to photic stimulation (moved light bars on a dark background) was augmented. These results reveal that, following application of melatonin, an improved signal-to-noise ratio is found in response to visual stimuli. The physiological source and putative action sites of melatonin are discussed with regard to its physiological role as a neuromodulating substance. The present data, in addition to previous work, suggest that melatonin is involved in visual information processing such as object detection and dark adaptation.
Reuss
S
S
Department of Anatomy, Johannes Gutenberg-University, Mainz, F.R.G.
Kiefer
W
W
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D005260:Female; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010775:Photic Stimulation; D013997:Time Factors; D014793:Visual Cortex / Q000187:drug effects*
D008550:Melatonin