The effect of the short-term administration of fish oil on serum lipoproteins in old people.
The effect of large-dose short-term administration of Max-Epa fish oil on serum lipoproteins in elderly people was studied. 17 elderly (aged 61-96 years) hospital patients were given an isocaloric diet which contained 70-80 ml (14-16 g of eicosapentaenoate) of Max-Epa fish oil for 3 weeks. The concentration of plasma total cholesterol and LDL cholesterol decreased significantly during the diet with fish oil. The levels of plasma VLDL cholesterol, HDL cholesterol and triglycerides decreased slightly (p less than 0.05). The concentration of apoprotein A decreased significantly (p less than 0.001) during the fish oil diet but the plasma level of apoprotein B did not change significantly. The ratio of apoprotein B to LDL cholesterol increased significantly (p less than 0.01) during the period with Max-Epa fish oil. The results show that marked changes in the lipoproteins of the elderly people occur when diet contains large doses of fish oil.
Lehtonen
A
A
Turku City Hospital, Finland.
Räihä
I
I
Puumalainen
R
R
Seppänen
A
A
Marniemi
J
J
D000368:Aged; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D004281:Docosahexaenoic Acids; D004338:Drug Combinations; D015118:Eicosapentaenoic Acid; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D004338:Drug Combinations; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D008074:Lipoproteins; C045153:Maxepa; D014280:Triglycerides; D004281:Docosahexaenoic Acids; D002784:Cholesterol; D015118:Eicosapentaenoic Acid