Spontaneous formation of helical strands from nucleic acid-lipid conjugates.
We have developed a new class of helical strands that self-assembled spontaneously in aqueous solution. Phospholipid-deoxynucleoside conjugates containing two myristoyl groups and a deoxynucleosidyl group spontaneously assembled to form different types of helical strands.
Yanagawa
H
H
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
Ogawa
Y
Y
Furuta
H
H
Tsuno
K
K
D004134:Dimyristoylphosphatidylcholine; D008854:Microscopy, Electron; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000138:chemical synthesis*; D010713:Phosphatidylcholines / Q000138:chemical synthesis*
D009705:Nucleosides; D010713:Phosphatidylcholines; D004134:Dimyristoylphosphatidylcholine