title: Influence of ionic and non-ionic radiographic contrast media on the vasomotor tone of epicardial coronary arteries.
abstract: The effect of ionic and non-ionic contrast media on the vasomotility of epicardial coronary arteries was investigated in 21 patients during coronary angiography by use of either diatrizoate-76% (10 patients, group A) or iopromide-370 (11 patients, group B). Coronary angiograms were taken in RAO 30 degrees projection before (= reference) and directly after (t0) diagnostic angiography of the left coronary artery (approx. 7 dye injections in approx. 7 min). Additional angiograms in the same projection followed after 1, 3, 6 and 10 min. Mean diameters of angiographically normal coronary segments were analysed with an automatic edge detection system (CAAS). With diatrizoate-76% coronary dilation at t0 averaged 18.9 +/- 6.7% (P less than 0.001); it correlated positively (P less than 0.001) with the number of diagnostic injections performed per min (mean 1.2 +/- 0.3 min-1), and negatively (P less than 0.5) with the time interval between the last diagnostic contrast injection and t0 (mean interval 73 +/- 35 s). Coronary dilation was unchanged 1 min after t0 (18.3 +/- 5.4%, P less than 0.001) and was still present after 6 min (6.2 +/- 4.6%, P less than 0.01). With iopromide-370 coronary dilation at t0 was mild (5.4 +/- 4.3%; P less than 0.05); the subsequent injections led to minimal insignificant dilation. It is concluded that in quantitative angiographic studies on changes in coronary vasomotor tone repeated coronary angiograms should be taken with non-ionic contrast media; furthermore adequate injection intervals of greater than 3 min should be observed.
authors.affiliation: Hannover Medical School, F.R.G.
authors.forename: S
authors.initials: S
authors.lastname: Jost
authors.forename: W
authors.initials: W
authors.lastname: Rafflenbeul
authors.forename: U
authors.initials: U
authors.lastname: Gerhardt
authors.forename: H
authors.initials: H
authors.lastname: Hecker
authors.forename: U
authors.initials: U
authors.lastname: Nellessen
authors.forename: G H
authors.initials: GH
authors.lastname: Reil
authors.forename: P R
authors.initials: PR
authors.lastname: Lichtlen
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000494:pharmacology*; D003327:Coronary Disease / Q000000981:diagnostic imaging; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology; D003973:Diatrizoate / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007472:Iohexol / Q000494:pharmacology* / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D009129:Muscle Tonus / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011859:Radiography; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D003287:Contrast Media; D003973:Diatrizoate; D007472:Iohexol; C038192:iopromide