[Water and sodium transport in different parts of the nephron in glomerulonephritis patients with nephrotic syndrome].
Altogether 34 patients with the nephrotic syndrome (NS) of chronic glomerulonephritis (CGN) were studied for lithium clearance (CLi). Eleven patients with edemas were enrolled in group I, 18 subjects without pronounced edemas, in group II. Out of them 7 patients suffered from membrane proliferative glomerulonephritis (group III), 7, from mesangioproliferative glomerulonephritis (group IV), 4 subjects had focal glomerulosclerosis (group V); chronic renal failure (CRF), stages IIb-IIIa, was diagnosed in 7 patients enlisted in group VI. The control group consisted of 11 virtually healthy persons. On the CLi basis the authors identified the proximal excretory water fraction (EFpH2O), the distal excretory fraction of the water (EFdH2O) and the distal excretory fraction of sodium (EFdNa). The controls demonstrated the mean values of the parameters considered: 16.18 +/- 1.56 ml/min; 19.88 +/- 1.63; 7.19 +/- 1.16 and 4.38 +/- 7.76 per cent, respectively. Decreased CLi was revealed in groups I and II. Versus the controls patients enrolled in group II demonstrated a significant decrease of EFpH2O (11.91 +/- 2.22 per cent; p less than 0.05) and an increase of EFdH2O (16.81 +/- 3.26 per cent; p less than 0.05). A great individual variance of the parameters considered (from 1.32 to 55.63 per cent and from 2.33 to 118 per cent, respectively) hindered to reveal the difference between group I and the controls.(ABSTRACT TRUNCATED AT 250 WORDS)
Kaiukov
I G
IG
Rogachev
B V
BV
Nikogosian
Iu A
IuA
Vereninov
A A
AA
Ivakhniuk
I S
IS
D001692:Biological Transport; D004487:Edema / Q000378:metabolism; D005921:Glomerulonephritis / Q000150:complications / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism; D008094:Lithium / Q000378:metabolism; D009399:Nephrons / Q000378:metabolism*; D009404:Nephrotic Syndrome / Q000209:etiology / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D014867:Water / Q000378:metabolism*
D014867:Water; D008094:Lithium; D012964:Sodium
Transport vody i natriia v razlichnykh uchastkakh nefrona u bol'nykh glomerulonefritom s nefroticheskim sindromom.