Different behavioral reactivity of 5-HT1 sites between killer and non-killer rats after midbrain raphe lesion.
A behavioral reactivity study on 5-HT1 and 5-HT2 sites of isolated killer and non-killer rats and on raphe lesioned killer and non-killer animals was undertaken, 5-HT1 reactivity was measured by a rank intensity scale on the forepaw treading and hind-limb abduction induced by 5-MeODMT. 5-HT2 reactivity was determined by the "shaking" behavior following 5-HTP. No behavioral differences on 5-HT1 and 5-HT2 sites were observed between isolated killer or non-killer animals. Similarly, comparable values of "shakes" were obtained on killer and non-killer lesioned rats. On the contrary, 5-MeODMT, induced a lower behavioral response on lesioned killer as compared to lesioned non-killer. This different behavioral response can not be explained by a probable difference of 5-HT terminals denervation since a similar reduction of 5-HT brain uptake was observed between both groups of rats. Finally, the decreased reactivity of 5-HT1 sites may be an index of a lower 5-HT neurotransmission and could therefore provide an explanation of the appearance of muricidal activity in some but not in all the lesioned rats.
Cuadra
G R
GR
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Molina
V A
VA
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal; D001665:Binding Sites; D002540:Cerebral Cortex / Q000378:metabolism; D008297:Male; D008732:Methoxydimethyltryptamines / Q000494:pharmacology; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000493:pharmacokinetics*
D008732:Methoxydimethyltryptamines; D011985:Receptors, Serotonin; D012701:Serotonin; D006916:5-Hydroxytryptophan