Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.
We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide. We describe a possible drug interaction between these two drugs and recommend that they should only be used together with caution.
Webberley
M J
MJ
Selly Oak Hospital, Birmingham, UK.
Murray
J A
JA
D000368:Aged; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000627:therapeutic use; D004347:Drug Interactions; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*; D007213:Indomethacin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D009101:Multiple Myeloma / Q000188:drug therapy; D014869:Water Intoxication / Q000139:chemically induced*
D003520:Cyclophosphamide; D007213:Indomethacin