title: Relation between splenic antibody formation and serum antibody levels to sheep erythrocytes as studied at the level of individual mice.
abstract: The relation between splenic antibody formation and serum antibody levels after intraperitoneal immunization of mice with sheep erythrocytes was studied in individual animals. A strong correlation between plaque-forming cell numbers in the spleen and haemolysin and haemagglutinin titres in the serum was observed. These results are at variance with recent data on the development of splenic auto-haemolysin-forming cells and corresponding serum levels after injection of mice with Escherichia coli endotoxin. The background behind the discrepancy between the antigen-driven immune response and the more polyclonal stimulation of B cells with endotoxin is being discussed.
authors.affiliation: Eijkman-Winkler Laboratory of Medical Microbiology, Faculty of Medicine, University of Utrecht, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Hol
authors.forename: F M
authors.initials: FM
authors.lastname: Hofhuis
authors.forename: H
authors.initials: H
authors.lastname: van Dijk
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology; D006388:Hemagglutinins / Q000032:analysis; D051379:Mice; D013154:Spleen / Q000276:immunology*
chemical_list: D006388:Hemagglutinins