[The use of dibunol for stimulating reparative processes in the cardiac muscle in myocardial infarct in rats].
The effects of dibunol (30 mg/kg) and inosie-F (40 mg/kg) on the cardiac muscle reparation were studied on 162 coronary artery ligated rats. The long-term administration (30 days) both of dibunol and inosie-F increased the rate of collagen synthesis in the infarction area. Dibunol averted the development of the left ventricular pump failure, while inosie-F didn't prevent the postinfarction depression of cardiac contractility.
Pichugin
V V
VV
Konorev
L A
LA
Polumiskov
V Iu
VIu
Karev
V A
VA
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D007290:Inosine Diphosphate / Q000627:therapeutic use; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical; D013997:Time Factors
D002084:Butylated Hydroxytoluene; D007290:Inosine Diphosphate
Primenenie dibunola dlia stimuliatsii reparativnykh protsessov v serdechnoĭ myshtse pri infarkte miokarda u krys.