title: Experimental determination of wall shear rate in canine carotid arteries perfused in vitro.
abstract: The mathematical model of Hung (Tsai and Hung, 1984) is employed to determine the wall shear rate acting on canine carotid arteries perfused in vitro. Model equations for pulsatile flow in a deformable vessel are coupled with experimental data of dynamic pressure drop, flow rate, vessel radius and radial wall motion. Derived quantities, e.g. velocity profiles and wall shear, are obtained for vessels exposed to 'normotensive' hemodynamics, 'hypertension' simulations and perfusions in which the compliance of the vessel wall is deliberately altered. Our results indicate that wall shear varies markedly as a function of the hemodynamic environment. The effects of vessel radius vs flow rate on the development of wall shear are also demonstrated. It is found that convective processes correlate with the magnitude of wall shear in the 'hypertension' simulations. The present findings and complementary published data may explain, at least in part, the variations in vessel wall transport and endothelial cell biology we observe as a function of the hemodynamic environment. For example we have documented that the exposure of canine carotids to 'hypertensive' (vs 'normotensive') hemodynamics is associated with an increased flux of lipoproteins (LDL) into the intima and luminal media. Alternations in wall compliance, on the other hand, profoundly influence endothelial shape, orientation and cytoskeletal array.
authors.affiliation: Department of Surgery, University of Pittsburgh, PA 15261.
authors.forename: G A
authors.initials: GA
authors.lastname: Johnson
authors.forename: T K
authors.initials: TK
authors.lastname: Hung
authors.forename: A M
authors.initials: AM
authors.lastname: Brant
authors.forename: H S
authors.initials: HS
authors.lastname: Borovetz
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002339:Carotid Arteries / Q000502:physiology* / Q000503:physiopathology; D004285:Dogs; D004730:Endothelium, Vascular / Q000502:physiology* / Q000503:physiopathology; D006439:Hemodynamics; D066298:In Vitro Techniques; D008077:Lipoproteins, LDL / Q000378:metabolism; D008432:Mathematical Computing; D008955:Models, Cardiovascular
chemical_list: D008077:Lipoproteins, LDL