title: Rate of chromosomal aberrations in prenatally detected hydrops fetalis and hygroma colli.
abstract: Chromosome analyses were carried out in a series of 775 fetuses with morphological abnormalities diagnosed by ultrasound. Among these cases, 57 demonstrated non-immune hydrops fetalis with hygroma colli (group 1) and a further 116 non-immune hydrops fetalis without hygroma colli (group 2). Different chromosome abnormalities were found in 54.5% of cases of group 1 where chromosome analyses could be performed, and in 27.6% of cases of group 2. The most common aberrations were monosomy X and trisomy 21.
authors.affiliation: Institut für Humangenetik der Universität, Bonn, Federal Republic of Germany.
authors.forename: G
authors.initials: G
authors.lastname: Schwanitz
authors.forename: K
authors.initials: K
authors.lastname: Zerres
authors.forename: U
authors.initials: U
authors.lastname: Gembruch
authors.forename: R
authors.initials: R
authors.lastname: Bald
authors.forename: M
authors.initials: M
authors.lastname: Hansmann
mesh_terms: D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D015160:Hydrops Fetalis / Q000175:diagnosis / Q000235:genetics*; D007621:Karyotyping; D008208:Lymphatic System / Q000002:abnormalities*; D008210:Lymphocele / Q000175:diagnosis / Q000196:embryology / Q000235:genetics*; D011247:Pregnancy; D011296:Prenatal Diagnosis