Isolation of a new tremorgenic indoloditerpene, 1'-O-acetylpaxilline, from Emericella striata and distribution of paxilline in Emericella spp.
The distribution of a tremorgenic mycotoxin, paxilline (1), was investigated in 19 species belonging to the genus Emericella. It was found that Emericella desertorum, E. foveolata, and E. striata produced paxilline (1). A new type of indoloditerpene, emindole DA (4), was also found in E. quadrilineata. A new tremorgenic indoloditerpene, 1'-O-acetylpaxilline (3), was isolated from the mycelium of E. striata. Its structure was established on the basis of spectroscopic investigations.
Nozawa
K
K
Horie
Y
Y
Udagawa
S
S
Kawai
K
K
Yamazaki
M
M
D000107:Acetylation; D000818:Animals; D001203:Ascomycota / Q000032:analysis / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D004224:Diterpenes / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D007211:Indoles / Q000032:analysis / Q000302:isolation & purification* / Q000378:metabolism* / Q000494:pharmacology; D051379:Mice; D014202:Tremor / Q000139:chemically induced*
D004224:Diterpenes; D007211:Indoles; C063361:1'-O-acetylpaxilline; C048220:paxilline