Quantitative determination of naltiazem in human plasma by gas chromatography/mass spectrometry.
A gas chromatographic/mass spectrometric procedure has been developed for the quantification of a diltiazem analog, naltiazem, in human plasma. The assay utilizes an extraction at neutral pH with hexane:ethylene dichloride:methyl-t-butyl ether (70:20:10), selective ion monitoring, methane or ammonia positive chemical ionization mass spectrometry and stable isotope dilution. The method has been used to analyze plasma concentrations of naltiazem in clinical samples over a range of 2-200 ng ml-1, using 1 ml of plasma.
Davis
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PP
Department of Drug Metabolism, Hoffman-La Roche Inc., Nutley, New Jersey 07110-1199.
Choma
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N
Crews
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T
Fukuda
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EK
D002121:Calcium Channel Blockers / Q000097:blood* / Q000493:pharmacokinetics; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013841:Thiazepines / Q000097:blood* / Q000493:pharmacokinetics
D002121:Calcium Channel Blockers; D013841:Thiazepines; C062703:naltiazem