Studies of renal function in animals chronically treated with apomorphine.
Based on the observation that orally administered apomorphine may induce nephrotoxicity, we studied the renal effects of a two-week subcutaneous infusion of apomorphine in rats. Drug-treated rats did not exhibit any change in renal cortical uptake of an organic cation (tetraethyl ammonium), organic anion (para-hippuric acid), creatinine clearance, or fractional excretion of sodium and potassium. Renal histology showed no change specific to drug. A small increase in urinary N-acetylglucosaminidase, a tubular enzyme, was measured but a second tubular enzyme showed no change. We conclude that parenterally administered apomorphine is not associated with renal toxicity.
Gancher
S T
ST
Department of Neurology, Oregon Health Sciences University, Portland 97201.
Bennett
W
W
English
J
J
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D007263:Infusions, Parenteral; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D007677:Kidney Function Tests; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D001058:Apomorphine