[The effect of baclofen on the nociceptive reactions of the blood pressure in waking rats].
The effect of baclophen (5-10 mg/kg) on the background arterial blood pressure (AP), amplitude of nociceptive AP reactions under electrostimulation of the tail's proximal part and the time of AP normalization after the nociceptive action was studied in the experiments of awaking rats with implanted arterial catheters. Baclophen in the range of analgesic doses causes persistent hypertension depending on the drug dose and the level of emotional reactivity of the rats. Simultaneously with the above mentioned effects the amplitude and the duration of the nociceptive AP reactions are decreased. The blockade of the alpha-adrenoreceptors (phenoxybenzamine, 5 mg/kg) abolishes the hypertensive effect of baclophen but increases its inhibitory effect on the nociceptive AP changes.
Ignatov
Iu D
IuD
Dmitriev
A V
AV
Darinskiĭ
Iu A
IuA
Smirnova
T A
TA
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004558:Electric Stimulation / Q000379:methods; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000503:physiopathology*; D010643:Phenoxybenzamine / Q000494:pharmacology; D051381:Rats; D012044:Regression Analysis; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D010643:Phenoxybenzamine; D001418:Baclofen
Vliianie baklofena na notsiteptivnye reaktsii arterial'nogo davleniia u bodrstvuiushchikh krys.