Comparison of immune responses to diphtheria and tetanus toxoids of various mouse strains.
Immune responses of 11 mouse strains with known genetical characteristics and two outbred strains to diphtheria and to tetanus toxoids were compared. Both diphtheria and tetanus antitoxins were titrated by passive hemagglutination. From the pattern of the immune response, the mouse strains tested may be classified into four groups. [1] Strains ddY (SPF) and ddY (conv) and those with haplotype H-2b, such as C57BL/6 and C57BL/10, were high responders to both toxoids. [2] Strains with H-2d, such as BALB/c, B10.D2 and DBA/2Cr, were intermediate responders to both toxoids. [3] Strains with H-2k, H-2a or, H-2m, such as C3H/He, B10.BR, B10.BR/SgSn, B10.A/SgSnJ and B10.AKM/O1a, were high responders to diphtheria toxoid but low responders to tetanus toxoid. [4] The strain with H-2h4, B10.A (4R), was a poor responder to both toxoids.
Kameyama
S
S
Department of Applied Immunology, National Institute of Health, Tokyo.
Nagaoka
F
F
Matuhasi
T
T
D000818:Animals; D004166:Diphtheria Antitoxin / Q000032:analysis; D004168:Diphtheria Toxoid / Q000276:immunology*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006386:Hemagglutination Tests; D051379:Mice / Q000276:immunology*; D009500:Neutralization Tests; D013743:Tetanus Antitoxin / Q000032:analysis; D013745:Tetanus Toxoid / Q000276:immunology*
D004166:Diphtheria Antitoxin; D004168:Diphtheria Toxoid; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D013743:Tetanus Antitoxin; D013745:Tetanus Toxoid