A biokinetic model of inhaled Cm compounds in dogs: application to human exposure data.
Curium isotopes are major by-products in irradiated nuclear reactor fuel and comprise a significant fraction of the alpha-emitting radionuclide inventory. Although little use is currently being made of purified Cm sources, such usage is possible if reprocessing of spent fuel becomes feasible. Because little information is available on the biokinetics and dosimetry of inhaled Cm compounds, a study was conducted in which adult beagle dogs received a single inhalation exposure to either a monodisperse aerosol of 244Cm2O3 (1.4 micron activity median aerodynamic diameter [AMAD]; sigma g = 1.16) or a polydisperse aerosol of 244Cm (NO3)3 (1.1 micron AMAD; sigma g = 1.74). At times ranging from 4 h to 2 y after exposure, animals were sacrificed and their tissues analyzed for Cm content. The data describing the uptake and retention of 244Cm in the different organs and tissues and the measured rates of excretion of these dogs formed the basis on which a biokinetic model of Cm metabolism was constructed. This Cm model was based on a previously published model of the biokinetics of 241Am that was shown to be applicable to data from human cases of inhalation exposure to 241Am aerosols. This Cm model was found to be adequate to describe the biological distribution of Cm in dogs and was also applied to the sparse data from humans. Reasonable agreement was found between the model predictions for lung retention of Cm and for urinary excretion patterns in humans.
Guilmette
R A
RA
Lovelace Inhalation Toxicology Research Institute, Albuquerque, NM 87185.
Mewhinney
J A
JA
D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D003476:Curium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004285:Dogs; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008954:Models, Biological; D009566:Nitrates; D013045:Species Specificity; D014018:Tissue Distribution
D000336:Aerosols; D009566:Nitrates; C026884:curium oxide; C029020:curium nitrate; D003476:Curium