title: A possible harmful late effect of methylprednisolone therapy on a time cluster of optic neuritis.
abstract: Clinical records of all patients (n = 26) suffering from optic neuritis during the last 16 years re-evaluated in relation to treatment. The patients were treated in 3 ways: with prednisone; with "pulse" megadoses of methylprednisolone; and untreated. A possibly frightening conversion to multiple sclerosis was seen in the group of patients with methylprednisolone, compared with the other 2 groups.
authors.affiliation: Department of Neurology, Soroka Medical Center, Beer Sheva, Israel.
authors.forename: Y O
authors.initials: YO
authors.lastname: Herishanu
authors.forename: S
authors.initials: S
authors.lastname: Badarna
authors.forename: B
authors.initials: B
authors.lastname: Sarov
authors.forename: J M
authors.initials: JM
authors.lastname: Abarbanel
authors.forename: S
authors.initials: S
authors.lastname: Segal
authors.forename: J E
authors.initials: JE
authors.lastname: Bearman
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000139:chemically induced*; D009902:Optic Neuritis / Q000188:drug therapy*
chemical_list: D008775:Methylprednisolone