[Biochemical changes in the connective tissue components of malignant tumors and lungs in mice during metastatic spreading and chemotherapy].
The highest content of hydroxyproline, hexuronic acids and hexoses was found in nonmetastatic tumor tissue Ca 755 of mice as compared with metastatic neoplasms carcinoma 3LL and melanoma B-16. Development of melanoma B-16 metastases involved the active lung stromal reaction, while carcinoma 3LL metastatic spreading did not cause any distinct connective tissue reactions in lungs. Non-toxic doses of drugs, operating via dissimilar mechanisms (cyclophosphane, trielin, parmidine), resulted in similar alterations of the connective tissue components studied in primary tumors of both carcinoma 3LL and melanoma B-16. Content of hydroxyproline, hexuronic acids and hexoses was increased in lung tissue of mice with carcinoma 3LL, simultaneously with distinct inhibition of metastases development after administration of these drugs. The chemotherapeutic treatment did not increase the stromal reaction of lungs with metastases of melanoma B-16 and its antimetastatic effect was less distinct as compared with carcinoma 3LL.
Chubinskaia
S G
SG
Sevast'ianova
N A
NA
Veksler
I G
IG
Slutskiĭ
L I
LI
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003094:Collagen / Q000378:metabolism; D003238:Connective Tissue / Q000378:metabolism*; D005260:Female; D006601:Hexoses / Q000378:metabolism; D006603:Hexuronic Acids / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism / Q000556:secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D014443:Tyrosine / Q000378:metabolism
D000970:Antineoplastic Agents; D006601:Hexoses; D006603:Hexuronic Acids; D014443:Tyrosine; D003094:Collagen; D006909:Hydroxyproline
Biokhimicheskie izmeneniia soedinitel'notkannykh komponentov zlokachestvennykh novoobrazovaniĭ i legkikh u mysheĭ pri metastazirovanii i primenenii khimiopreparatov.