The effect of parathyroid hormone and 1,25 (OH)2D3 on nerve conductance in patients on maintenance hemodialysis.
In 30 uremic patients on chronic maintenance hemodialysis the sensory and motor fiber conduction and the motor distal latency were measured in the left tibial nerve, in order to evaluate if a correlation between their values and the serum IPTH or 1.25(OH)2D3 can be found. The sensory and motor fiber conduction velocities were found to be significantly lower in hemodialysis patients than in a group of healthy controls. The motor distal latency time did not differ significantly from that found in healthy persons. A markedly increased serum C-terminal and mid-region (44-68) iPTH, and a very low serum 1.25(OH)2D3 were found in uremic patients. Regression analyses demonstrated the significant negative correlations between the serum C-terminal iPTH and the sensory (r = -0.441, p less than 0.05) and motor nerve (r -0.471, p less than 0.01) conduction velocities. A significant positive correlation between serum 1.25(OH)2D3 levels and the motor distal latency time was also observed (r = 0.3639, p less than 0.05). The results obtained suggest a role of the increased concentration of IPTH fragments in the development of uremic polyneuropathy. A significant decrease of 1.25(OH)2D3 obviously has no negative effect upon the nerve conductance in patients on maintenance hemodialysis.
Ivić
M A
MA
Kostić
S
S
Strahinjić
S
S
Stefanović
V
V
D000328:Adult; D000368:Aged; D002117:Calcitriol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D009431:Neural Conduction / Q000187:drug effects*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D010281:Parathyroid Hormone / Q000494:pharmacology*; D006435:Renal Dialysis
D010281:Parathyroid Hormone; D002117:Calcitriol