title: Absorption kinetics of cyclosporine in healthy volunteers.
abstract: The absorption kinetics of cyclosporine were studied in eight healthy volunteers following oral and intravenous administration. Bioavailability of cyclosporine was observed to be 20.8 +/- 5.5 per cent. Absorption of cyclosporine was found to be better described by first order processes rather than by a zero order process as previously reported.
authors.affiliation: Department of Pharmacy, School of Pharmacy, University of California, San Francisco 94143-0446.
authors.forename: S K
authors.initials: SK
authors.lastname: Gupta
authors.forename: L Z
authors.initials: LZ
authors.lastname: Benet
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D003524:Cyclosporins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007408:Intestinal Absorption; D008297:Male
chemical_list: D003524:Cyclosporins