Teratogen susceptibility of XO mothers and XO embryos in mice.
We examined whether the chromosomal imbalance inherent in an XO constitution in mice is more susceptible to teratogenic influence of biotin deficiency using a newly established mouse colony with pure X monosomy. We hypothesized that XO mothers or XO embryos might be more susceptible to certain teratogens. Contrary to our expectation, the incidence of external malformations induced by biotin deficiency did not differ either between XX dams and XO dams or between XX fetuses and XO fetuses.
Endo
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A
Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Japan.
Watanabe
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T
D000818:Animals; D001710:Biotin / Q000633:toxicity*; D002872:Chromosome Deletion; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D009006:Monosomy; D014960:X Chromosome
D001710:Biotin