Effect of dietary lithium on cortical spreading depression.
The influence of lithium administration on cortical spreading depression (SD) was investigated in rats whelped by dams fed a diet containing lithium (1.5 g/kg) during the gestation or the lactation periods. Velocity of SD propagation was measured when the rats became adults and was similar to that of rats raised on a normal diet. A third group of adult rats received lithium during the three weeks preceding SD recordings and presented a significant reduction in SD velocity as compared to control rats. These data suggest that in adult rats a brief treatment with lithium impairs SD propagation, whereas much earlier treatment does not.
Guedes
R C
RC
Departamento de Nutriçäo, Universidade Federal de Pernambuco, Recife, PE, Brasil.
Amorim
L F
LF
Medeiros
M C
MC
Silva
A T
AT
Teodósio
N R
NR
D000818:Animals; D013181:Cortical Spreading Depression / Q000187:drug effects*; D004032:Diet; D005260:Female; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains
D008094:Lithium