Effect of glucagon on glucose output from bivascularly perfused rat liver.
Glucose output was investigated in bivascularly perfused rat liver. Flow rate was 1 ml/min/g from hepatic artery and 2 ml/min/g from portal vein. Basal glucose output (130 +/- 30 microM/min) from bivascularly perfused liver was significantly (p less than 0.02) higher than that (80 +/- 20 microM/min) from usual monovascularly perfused (3 ml/min/g from portal vein) liver. However, glucagon-induced (1 ng/ml) increment in glucose output from bivascularly perfused liver 589 +/- 127 microM/30 min) was not significantly different from that (630 +/- 127 microM/30 min) of monovascularly perfused liver. These results suggest that glucagon-dependent glucose output was similar in monovascularly and bivascularly perfused rat liver, and that arterial blood supply may have some role in glycogenolysis in the perfused rat liver.
Ikeda
T
T
The First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
Hoshino
T
T
Honda
M
M
Takeuchi
T
T
Mokuda
O
O
Tominaga
M
M
Mashiba
H
H
D000818:Animals; D005934:Glucagon / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D011169:Portal Vein; D051381:Rats; D011919:Rats, Inbred Strains
D005934:Glucagon; D005947:Glucose