[Characteristics of the psychotropic action of melatonin in relation to the dosage and time of day].
When administered in a low dose (0.1 mg/kg) the main pineal hormone melatonin decreased the locomotor activity and exploratory behavior of rats in the open field both during the light and dark phases of the day. High doses (1.0 and 10.0 mg/kg) were effective only at night hours (01.00-03.00). After administration of 0.1 mg/kg of melatonin no changes in the main parameters and rhythmicity of forced swimming occurred irrespective of the time of use. However the effect of 1.0 mg/kg of the hormone in the daytime manifested itself in an increase of the immobility and a decrease of the depression index.
Arushanian
E B
EB
Ovanesov
K V
KV
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008550:Melatonin / Q000008:administration & dosage / Q000494:pharmacology*; D005082:Physical Exertion / Q000187:drug effects; D011619:Psychotropic Drugs; D051381:Rats; D013550:Swimming; D013997:Time Factors
D011619:Psychotropic Drugs; D008550:Melatonin
Osobennosti psikhotropnogo deĭstviia melatonina v zavisimosti ot dozy i vremeni sutok.