Pressor responses to common carotid occlusion in female rats: effects of gonadectomy and treatment with gonadal steroid hormones.
The pressor responses to common carotid occlusion were studied in conscious female rats throughout the estrous cycle, after gonadectomy and after gonadectomy followed by treatment with estrogen and progesterone. The initial peak pressor response was highest during proestrus and fell significantly over the remaining 3 days of the estrous cycle. The maintained pressor response was relatively unchanged throughout the cycle, except during diestrus 1 when it decreased markedly. Gonadectomy reduced and treatment with estradiol alone increased the initial pressor component, respectively. Treatment of gonadectomized rats with estradiol plus progesterone enhanced both components. These findings suggest that gonadal steroid hormones are important modulators of the pressor response to common carotid occlusion.
Bedran-de-Castro
M T
MT
Departamento de Ciências Fisiológicas, Faculdade de Odontologia de Araçatuba, Universidade Estadual Paulista, SP, Brasil.
Delben
A C
AC
Silva
A N
AN
Bedran-de-Castro
J C
JC
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D001794:Blood Pressure; D002340:Carotid Artery Diseases / Q000503:physiopathology*; D004958:Estradiol / Q000627:therapeutic use; D004971:Estrus; D005260:Female; D010052:Ovariectomy; D011374:Progesterone / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D011374:Progesterone; D004958:Estradiol