title: [Use of a slow-release form of salbutamol in the treatment of threatened premature labor. A comparative study of 52 randomized cases compared with the immediate release form].
abstract: A randomised study was carried out to compare the effect of ordinary salbutamol with controlled release salbutamol as far as the sedative effect on the uterine muscle was concerned. Modifying the molecule for salbutamol gives it characteristics of a true "retard" form. This makes it possible to prescribe 2 tablets a day in 2 doses to copy the sedative effect on uterine muscle achieved when the treatment is given intravenously in cases of threatened onset of labour. The study was a double blind one with a placebo being used in two parallel groups after the populations had been compared for similar characteristics as far as the past history, the body build and the number of pregnancies was concerned. This made it possible to show that the two forms are strictly comparable and that there are no adverse side effects. This form of "retard" salbutamol seems to be particularly useful in repeated attacks of threatened premature labour and makes it likely that it will be taken more regularly with the avoidance of peaks in plasma and therefore improved tolerance. Furthermore, the action is longer and effective overnight.
authors.affiliation: Clinique Universitaire de Gynécologie-Obstétrique et Pathologie de la Reproduction, Université de Lille II, Roubaix.
authors.forename: G
authors.initials: G
authors.lastname: Crépin
authors.forename: M
authors.initials: M
authors.lastname: Delcroix
authors.forename: D
authors.initials: D
authors.lastname: Parmentier
authors.forename: M H
authors.initials: MH
authors.lastname: Adam
authors.forename: D
authors.initials: D
authors.lastname: Renon
authors.forename: D
authors.initials: D
authors.lastname: Georges
mesh_terms: D000420:Albuterol / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D011897:Random Allocation; D015145:Tocolysis
chemical_list: D003692:Delayed-Action Preparations; D000420:Albuterol
vernacular_title: Utilisation d'une forme "retard" de salbutamol dans le traitement des menaces d'accouchement prématuré. Etude comparative de 52 cas randomisés avec la forme à libération immédiate.