[The correlation between the frequency of sister chromatid exchanges and the kinetics of human lymphocyte proliferation: the dependence on the sex of the donor].
Sister chromatid exchanges (SCE) and average generation time (AGT) were studied in lymphocytes from 35 donors (23 females and 12 males). A higher SCE frequency was found in lymphocytes from females than from males. Smoking increased SCE frequency in lymphocytes of males, but not of females. No differences in AGTs between males and females were found. Partial correlation coefficients between SCE frequency, AGT values, donor's age and smoking were determined. A statistically significant correlation (r = 0.650, P less than 0.01) between SCE frequency and AGT was found in lymphocytes obtained from females. In lymphocytes from males statistically significant partial correlation coefficients were detected between SCE frequency and AGT (r = -0.696, P less than 0.05), SCE frequency and donor's age (r = 0.770, P less than 0.01), SCE frequency and smoking intensity (r = 0.697, P less than 0.01), AGT value and donor's age (r = 0.882, P less than 0.01), and AGT value and smoking (r = 0.634, P less than 0.05). Thus, considerable differences in number of indices between males and females exist. The present observations together with other studies (D'Souza et al., 1988) suggest that considerations for population monitoring using cytogenetic techniques (ICPEMC Publication No 14) may be supplemented with the recommendation to use (whenever it possible) only males as donors in population studies.
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D000328:Adult; D000375:Aging; D002455:Cell Division; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D012727:Sex Characteristics; D012854:Sister Chromatid Exchange; D012907:Smoking / Q000009:adverse effects
Korreliatsiia mezhdu chastotoĭ sestrinskikh khromatidnykh obmenov i kinetikoĭ proliferatsii limfotsitov cheloveka: zavisimost' ot pola donora.