title: Eremomycin--new glycopeptide antibiotic: chemical properties and structure.
abstract: By a combination of chemical and spectroscopic (1H and 13C NMR) studies the structure of a glycopeptide antibiotic eremomycin has been elucidated. It is closely related to vancomycin, but differs in sugar and chlorine content. The eremomycin aglycone contains monodechlorovancomycinic acid; the only chlorine atom is situated in the second amino acid after the N-terminal amino acid residue of the peptide. The sugar part is composed of glucose and two residues of an amino sugar shown to be 2,3,6-trideoxy-3-amino-C-3-methyl-L-arabino-hexopyranose (4-epi-vancosamine). One of the amino sugar residues is a component of the disaccharide 2-O-(alpha-L-4-epi-vancosaminyl)-beta-D-glucopyranose, attached to a triphenyl ether moiety; the position of another one is at the serine oxygen in the C-terminal region of the aglycone.
authors.affiliation: Institute of New Antibiotics, Academy of Medical Science, Moscow, USSR.
authors.forename: G F
authors.initials: GF
authors.lastname: Gause
authors.forename: M G
authors.initials: MG
authors.lastname: Brazhnikova
authors.forename: N N
authors.initials: NN
authors.lastname: Lomakina
authors.forename: T F
authors.initials: TF
authors.lastname: Berdnikova
authors.forename: G B
authors.initials: GB
authors.lastname: Fedorova
authors.forename: N L
authors.initials: NL
authors.lastname: Tokareva
authors.forename: V N
authors.initials: VN
authors.lastname: Borisova
authors.forename: G Y
authors.initials: GY
authors.lastname: Batta
mesh_terms: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D055598:Chemical Phenomena; D002621:Chemistry; D006020:Glycopeptides; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D010455:Peptides; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D006020:Glycopeptides; D010455:Peptides; C053759:eremomycin; C057759:eremomycin aglycone