Comparative bioavailability of two brands of chlorpropamide in Kenyans.
The relative bioavailability of two brands of chlorpropamide, Dibonis, and Diabinese has been evaluated in four healthy male volunteers in a randomized, balanced, cross-over study. No statistically significant differences were observed in the absorption rate constant, ka, time to reach peak serum concentration, tp, maximum serum concentration, Cmax, the overall elimination rate constant, kel, and the area under the curve, AUC, at 95% confidence level.
Ondari
C O
CO
Kibwage
I O
IO
Ndemo
F A
FA
McLigeyo
S I
SI
D000328:Adult; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000592:standards*; D002747:Chlorpropamide / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007630:Kenya; D008297:Male; D013810:Therapeutic Equivalency
D002747:Chlorpropamide