Histamine turnover in the rat hypothalamic nuclei estimated from alpha-fluoromethylhistidine-induced histamine decrease.
The turnover rates, rate constants and half-life values of neuronal histamine (HA) in 10 nuclei of the rat hypothalamus were estimated from the depletion of HA induced by alpha-fluoromethylhistidine (alpha-FMH: 100 mg/kg, i.p.), a specific inhibitor of histidine decarboxylase, on the presumption that alpha-FMH depletable HA pools represent neuronal ones. Marked variation in the HA turnover rates were observed among the hypothalamic nuclei, ranging from 5.7 to 19.5 pmole/mg protein/hr.
Itoh
Y
Y
Department of Pharmacology, Okayama University Medical School, Japan.
Oishi
R
R
Nishibori
M
M
Saeki
K
K
D000818:Animals; D006207:Half-Life; D006632:Histamine / Q000378:metabolism*; D006639:Histidine / Q000031:analogs & derivatives*; D007031:Hypothalamus / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008762:Methylhistidines; D051381:Rats
D008762:Methylhistidines; D006639:Histidine; C028309:alpha-fluoromethylhistidine; D006632:Histamine