title: Effects of chronic optical defocus on the kitten's refractive status.
abstract: Lid closure initiated early in life produces axial myopia in a variety of species. However, it is currently not known what aspects of the anomalous visual experience associated with lid closure disrupt the emmetropization process and cause abnormal ocular axial elongation. This study was designed to determine if a degradation in the quality of the spatial characteristics of the retinal image was sufficient to produce an experimental myopia. Optical rearing procedures were employed to defocus one eye of developing kittens, and retinoscopic and ultrasonic procedures were used to evaluate the effects of chronic optical defocus on the kitten's refractive status. Different defocusing lens designs and rearing protocols were included to evaluate variables that may have confounded previous investigations. The major finding is that early chronic optical defocus results in axial myopia. The prevalence and magnitude of the induced refractive errors were dependent on the magnitude of optical defocus, but they were not affected by the sign or form of the defocusing lens. The results demonstrated that the potential for a clear retinal image is important for regulating normal ocular growth and maintaining a near emmetropic refractive status.
authors.affiliation: College of Optometry, University of Houston, Texas 77204-6052.
authors.forename: J
authors.initials: J
authors.lastname: Ni
authors.forename: E L
authors.initials: EL
authors.lastname: Smith
mesh_terms: D000818:Animals; D002415:Cats; D003261:Contact Lenses; D005123:Eye / Q000033:anatomy & histology / Q000254:growth & development; D005139:Eyeglasses; D009216:Myopia / Q000209:etiology*; D012030:Refractive Errors / Q000150:complications*