Long term actions of d-fenfluramine in two rat models of obesity. I Sustained reductions in body weight and adiposity without depletion of brain serotonin.
In a treatment regimen designed to simulate clinical situations, d-fenfluramine was administered chronically (28 days) via osmotic minipumps to lean and obese female rats. Drug effects were assessed in dietary obese, ovariectomized obese, estradiol-treated ovariectomized and unoperated Chow-fed rats. Various central and peripheral effects of d-fenfluramine were measured and compared to effects of dietary restriction as well as posttreatment changes. d-Fenfluramine suppressed food intake and body weight in all but estradiol-treated rats and was especially effective in obese ovariectomized rats. This method of administration did not deplete brain 5-HT within 28 days. The measured drug actions that may be important in: appetite suppression and weight loss include chronic stimulation of brain 5-HT activity without depletion; stimulation of (Na+- K+)ATPase activity; reduction in lipoprotein lipase activity and effects on carbohydrate metabolism.
Carlton
J
J
Department of Psychology, University of Florida, Gainesville.
Rowland
N E
NE
D000273:Adipose Tissue / Q000201:enzymology / Q000473:pathology*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology*; D050356:Lipid Metabolism; D008071:Lipoprotein Lipase / Q000378:metabolism; D009765:Obesity / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000096:biosynthesis*; D015431:Weight Loss
D005277:Fenfluramine; D012701:Serotonin; D008071:Lipoprotein Lipase