Heteroarylalkanoic acids with possible antiinflammatoric activities. Part 6: 3-(4H-1,2,4-benzothiadiazine-1,1-dioxide-3-yl-thio)-propanoic acid derivatives.
A series of 3-(4H-1,2,4-benzothiadiazine-1,1-dioxide-3-yl-thio)-propanoic acids was synthesized in order to study their possible antiinflammatory in comparison with the corresponding lower homologues and isosters previously studied. Most of the compounds proved effective against carrageenan-induced plantar oedema. The possible influence of some chemico-physical parameters on the occurrence of this biological activity was investigated.
Gamberini
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G
Cattedra di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia dell'Università di Modena, Italia.
Parenti
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C
Costantino
L
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Di Bella
M
M
Raffa
L
L
Rossi
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T
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D001581:Benzothiadiazines / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003497:Cyclic N-Oxides / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D011422:Propionates / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001581:Benzothiadiazines; D003497:Cyclic N-Oxides; D011422:Propionates