Developmental changes in expression of a tumor-associated protein in the rat fetus.
Monoclonal antibodies specific for a rat tumor-associated protein cross-react with a similar protein present in the cytosol of the rat fetus. The oncofetal protein exists as two species of approximate molecular weight 50 and 55 kDa which promote the transport of RNA from isolated nuclei. During rat fetal development, the protein first increases in concentration from approximately 12 to 16 days gestation and then drops to non-detectable levels perinatally.
Runge
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SW
Department of Physiological Chemistry, Ohio State University, College of Medicine, Columbus 43210.
Larroya
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S
Schumm
D E
DE
Webb
T E
TE
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000951:Antigens, Neoplasm / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D003429:Cross Reactions; D003600:Cytosol / Q000032:analysis; D005314:Embryonic and Fetal Development / Q000502:physiology*; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; C031192:oncofetal antigens