title: Temporal variations in the erythrocyte permeability to bupivacaine, etidocaine and mepivacaine in mice.
abstract: Temporal changes in membrane permeability to bupivacaine (B), etidocaine (E) and mepivacaine (M) documented by their erythrocytic penetration were studied in mice. Temporal variations of B, E and M erythrocytic penetration were demonstrated with a maximum at 04.00 h for B (amplitude = 148%), 10.00 h for E (amplitude = 146%) and at 10.00 h for M (amplitude = 75%). Differences in the circadian pattern of erythrocytic penetration of B, E and M are discussed according to physicochemical properties of these three agents.
authors.affiliation: Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille.
authors.forename: B
authors.initials: B
authors.lastname: Bruguerolle
authors.forename: M
authors.initials: M
authors.lastname: Prat
mesh_terms: D000083:Acetanilides / Q000493:pharmacokinetics*; D000818:Animals; D002045:Bupivacaine / Q000493:pharmacokinetics*; D002463:Cell Membrane Permeability / Q000502:physiology*; D002940:Circadian Rhythm; D004910:Erythrocyte Membrane / Q000378:metabolism; D005041:Etidocaine / Q000493:pharmacokinetics*; D007274:Injections, Intraperitoneal; D008297:Male; D008619:Mepivacaine / Q000493:pharmacokinetics*; D051379:Mice
chemical_list: D000083:Acetanilides; D008619:Mepivacaine; D005041:Etidocaine; D002045:Bupivacaine