[Prognostic significance of arterial blood pressure levels and the effectiveness of the treatment of arterial hypertension in a non-organized male population 40-59 years of age in Moscow].
Isolated working rat hearts were subjected to a 3-hour ischemia followed by reperfusion. The defense effects of the heart cooling to 6-7 and 12-15 degrees C were assessed according to the degree of postischemic recovery of hemodynamic (arterial pressure, heart rate, coronary flow, cardiac output) and biochemical (ATP, phosphocreatine, Pi, and lactate content) characteristics and electron microscopic evidence. The energy resources of the myocardium and its cellular structures were effectively preserved during one-hour ischemia at 12-15 degrees C. At 6-7 degrees C, the energy resources of the hearts were better preserved in long-term ischemia, where the functional characteristics were recovered to the same extent as in the 12-15 degrees C hypothermia, but some cell damage was observed. The obtained findings suggested that the temperature of 12-15 degrees C should be the temperature of choice for heart cooling in cardiosurgery.
Kalinina
A M
AM
Chazova
L V
LV
Shchepkin
V V
VV
D000328:Adult; D000367:Age Factors; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000401:mortality / Q000517:prevention & control; D003327:Coronary Disease / Q000209:etiology* / Q000401:mortality / Q000517:prevention & control; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009031:Moscow; D011379:Prognosis
D000959:Antihypertensive Agents
Prognosticheskaia znachimost' urovnia arterial'nogo davleniia i éffektivnost' meropriiatiĭ po lecheniiu arterial'noĭ gipertonii v neorganizovannoĭ populiatsii muzhchin 40-59 let Moskvy.