title: [Neoplasms associated with chronic lymphatic leukemia. Incidence and characteristics in a series of 232 patients].
abstract: The frequency and features of associated neoplastic diseases and their impact on survival were evaluated in a series of 232 patients with chronic lymphocytic leukemia (CLL) who had been diagnosed during an 18 year period. Thirty-two patients (13.8%) had overall 38 neoplasias, 27 of which were diagnosed after CLL. There were no significant differences in the initial clinical and hematological features of the patients depending on whether they had or not a second neoplastic disease or on the time of its development. When compared with the normal population of similar age and sex, the patients with CLL, particularly females, had and increased risk to develop other tumors. The actuarial analysis showed that the risk of developing associated tumors increased through time up to 36% nine years after the diagnosis (27% when skin neoplasias were excluded). Although differences in survival were not found between patients with CLL and associated tumor and the rest of the series, most patients with noncutaneous neoplasia died as a direct consequence of it 18 months after its diagnosis.
authors.forename: A
authors.initials: A
authors.lastname: López-Guillermo
authors.forename: J C
authors.initials: JC
authors.lastname: Reverter
authors.forename: F
authors.initials: F
authors.lastname: Cervantes
authors.forename: N
authors.initials: N
authors.lastname: Viñolas
authors.forename: M
authors.initials: M
authors.lastname: Rovira
authors.forename: A
authors.initials: A
authors.lastname: Urbano-Ispizua
authors.forename: E
authors.initials: E
authors.lastname: Montserrat
authors.forename: C
authors.initials: C
authors.lastname: Rozman
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002699:Chlorambucil / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D011379:Prognosis; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors
chemical_list: D002699:Chlorambucil; D003520:Cyclophosphamide
vernacular_title: Neoplasias asociadas a la leucemia linfática crónica. Incidencia y características en una serie de 232 pacientes.