Arterial compliance in uraemia.
Aortic and brachial pulse wave velocity were measured in 26 haemodialysis patients in order to assess the effect of uraemic waste-product retention on arterial compliance. Dialysis with a 'low-calcium' dialysate (1.50 mmol/l) did not change the pulse wave velocity, but dialysis with a 'high-calcium' dialysate (1.75 mmol/l) induced a significant increase in both aortic and brachial pulse wave velocity. The results indicate that (1) waste-product retention is not responsible for the increased arterial pulse wave velocity observed in uraemic patients and (2) the increase in serum ionized calcium decreases arterial compliance.
Marchais
S
S
Hôpital Manhes, Fleury Merogis, France.
Guérin
A
A
Safar
M
M
London
G
G
D001158:Arteries / Q000503:physiopathology*; D002118:Calcium / Q000008:administration & dosage / Q000097:blood; D015314:Dialysis Solutions / Q000008:administration & dosage; D006801:Humans; D011674:Pulse / Q000502:physiology; D011897:Random Allocation; D006435:Renal Dialysis / Q000379:methods; D014511:Uremia / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D014655:Vascular Resistance / Q000502:physiology*
D015314:Dialysis Solutions; D002118:Calcium