title: Lipoprotein, apolipoprotein, and lipolytic enzyme changes following estrogen administration in postmenopausal women.
abstract: To test whether estrogen can modulate the cholesterolemic response to an Occidental diet, six healthy postmenopausal women were studied for 84 days while ingesting a solid food diet of constant composition high in cholesterol content (995 mg/d). In the middle of the study, estrogen (17 alpha-ethinyl estradiol, 1 microgram/kg per day) was administered orally. Ingestion of the diet for the initial 28 days did not alter lipoprotein lipid or apolipoprotein (apo) levels. However, with just 4 days of estrogen use there were significant decreases in apoE (-36%), low density lipoprotein cholesterol (-26%), and postheparin plasma hepatic triglyceride lipase activity (HTGL) (-61%), and an increase in high density lipoprotein (HDL) triglyceride (72%). These changes persisted throughout the estrogen use. The percent change in HTGL with 4 days of estrogen correlated inversely with the percent change in HDL triglyceride (rs = -0.94). After 28 days of estrogen there were also significant increases in HDL cholesterol (21%), HDL2 cholesterol (42%), apoA-I (37%), and apoA-II (9%), and a decrease in apoB (-11%). The level of apoE at this juncture correlated inversely with the level of HDL cholesterol (rs = -0.90), and the levels of HTGL and apoA-I correlated with HDL2 cholesterol (rs = -0.89 and rs = 0.89, respectively). Thus, HTGL may play a role in both the early estrogen-related changes in HDL triglyceride and apoE and the late estrogen-related changes in HDL cholesterol, apoA-I, and apoA-II.
authors.affiliation: Department of Medicine, University of Washington School of Medicine, Seattle 98195.
authors.forename: D
authors.initials: D
authors.lastname: Applebaum-Bowden
authors.forename: P
authors.initials: P
authors.lastname: McLean
authors.forename: A
authors.initials: A
authors.lastname: Steinmetz
authors.forename: D
authors.initials: D
authors.lastname: Fontana
authors.forename: C
authors.initials: C
authors.lastname: Matthys
authors.forename: G R
authors.initials: GR
authors.lastname: Warnick
authors.forename: M
authors.initials: M
authors.lastname: Cheung
authors.forename: J J
authors.initials: JJ
authors.lastname: Albers
authors.forename: W R
authors.initials: WR
authors.lastname: Hazzard
mesh_terms: D000368:Aged; D001053:Apolipoproteins / Q000097:blood* / Q000187:drug effects; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008049:Lipase / Q000097:blood*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood* / Q000187:drug effects; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood
chemical_list: D001053:Apolipoproteins; D008055:Lipids; D008074:Lipoproteins; D004997:Ethinyl Estradiol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D008049:Lipase