[Leucine aminopeptidase activity levels in various brain regions in the rat. Effect of the acute administration of lithium].
Lithium is widely accepted as an effective treatment in acute mania. However, the neurochemical mechanism of action of the ion still remains relatively obscure. In this work, the effect of acute lithium administration on Leu-aminopeptidase activity in discrete areas of the rat brain is described. Decreases in enzyme activity in the striatum and pituitary gland were observed. It is suggested that this enzyme plays a part in the mechanism of action of lithium through regulation of the activity of some neuroactive peptides.
de Gandarias
J M
JM
Múgica
J
J
Irazusta
J
J
Echevarría
E
E
Casis
L
L
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D007274:Injections, Intraperitoneal; D007931:Leucyl Aminopeptidase / Q000378:metabolism*; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D008094:Lithium; D007931:Leucyl Aminopeptidase
Niveles de actividad de leu-aminopeptidasa en diversas regiones cerebrales de la rata. Efecto de la administración aguda de litio.