title: Pathophysiological variations in the rat liver plasma membrane serine proteinase activity.
abstract: The effects of fasting, diabetes, cholestasis, two-third hepatectomy and adrenalectomy on the rat liver plasma membrane serine proteinase activity were studied. Our results show a significant decrease of the enzyme activity during fasting (-50%), during experimental diabetes (-50%), in regenerating liver after partial hepatectomy (-70%) and after extrahepatic cholestasis (-70%). No modifications are noted when the rats are bilaterally adrenalectomized. These findings suggest that the enzyme activity may be linked to the level of circulating insulin, and may be regulated in physiological cellular proliferation so as to prevent undesirable protein degradation.
authors.affiliation: Laboratoire de Biochimie Médicale B, Faculté de Médecine, Rennes, France.
authors.forename: L
authors.initials: L
authors.lastname: Guenet
authors.forename: F
authors.initials: F
authors.lastname: Gueble-Val
authors.forename: C
authors.initials: C
authors.lastname: Prodhomme
authors.forename: G
authors.initials: G
authors.lastname: Leray
authors.forename: A M
authors.initials: AM
authors.lastname: Jouanolle
authors.forename: A
authors.initials: A
authors.lastname: Le Treut
mesh_terms: D000315:Adrenalectomy; D000367:Age Factors; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D002779:Cholestasis / Q000201:enzymology; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology; D005215:Fasting / Q000378:metabolism; D005260:Female; D006498:Hepatectomy; D008099:Liver / Q000201:enzymology* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012697:Serine Endopeptidases / Q000378:metabolism*
chemical_list: D012697:Serine Endopeptidases