Kinetics of amiloride in rat following oral and intravenous administration.
The disposition profile of amiloride, a potassium sparing agent, was studied in rats by using an HPLC method coupled to spectrofluorometric detection. Amiloride was administered orally and intravenously at the dose of 10 mg/Kg. The most relevant pharmacokinetic parameters are described for both administration routes.
Runci
F M
FM
Cerretani
D
D
Bianchi
E
E
Bruni
G
G
Giorgi
G
G
D000284:Administration, Oral; D000584:Amiloride / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000584:Amiloride