Suppression of the activities of T-lymphocyte-related enzymes in spleen by administration of an immunosuppressant, 15-deoxyspergualin.
We investigated the effects of both (-) and (+)-enantiomers of 15-deoxyspergualin (DSG), an immunosuppressant, on enzyme networks in spleens of ICR mice. Of the 14 hydrolytic enzymes tested, the activity of dipeptidyl aminopeptidase IV (DAP-IV) was found to be significantly suppressed by the administration of (-)-DSG but not by that of (+)-DSG. In contrast, the activity of N-acetyl-beta-D-glucosaminidase (GlcNAc-ase) was suppressed by the administration of both enantiomers of DSG. Judging from the previous reports of ours and others which suggested specific relations of these enzymes to T-lymphocytes, the above findings may warrant further studies of these enzymes in relation to immunologic functions of the body.
Aoyagi
T
T
Institute of Microbial Chemistry, Tokyo, Japan.
Wada
T
T
Iinuma
H
H
Ogawa
K
K
Kojima
F
F
Takeuchi
T
T
Kuroda
H
H
Ohbayashi
A
A
D000118:Acetylglucosaminidase / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006146:Guanidines / Q000494:pharmacology*; D006596:Hexosaminidases / Q000378:metabolism*; D007166:Immunosuppressive Agents; D008297:Male; D051379:Mice; D013154:Spleen / Q000201:enzymology*; D013379:Substrate Specificity; D013601:T-Lymphocytes / Q000201:enzymology*
D006146:Guanidines; D007166:Immunosuppressive Agents; D006596:Hexosaminidases; D000118:Acetylglucosaminidase; C037258:gusperimus