[Photochemotherapy of experimental tumors in animals using various photosensitizers].
Different colouring matters with high molar extinction coefficient were tested at the Friedrich Schiller University with regard to their photodynamic efficacy. Test system was the rapid-growing solid Ehrlich carcinoma. Methylen-blue, hematoporphyrin derivative Halle and chlorophyllin produce a markedly reduction of the tumor weight. In the presence of hypoxic areas an additional application of nitroimidazols is possible. A pilot laser unit for photochemotherapy of urinary bladder tumors is presented.
König
K
K
Arbeitsgruppe Laser in der Medizin, Friedrich-Schiller-Universität Jena.
Bockhorn
V
V
Dietel
W
W
Schubert
H
H
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D015687:Cell Hypoxia / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006414:Hematoporphyrin Photoradiation / Q000379:methods*; D051379:Mice; D008813:Mice, Inbred ICR; D009368:Neoplasm Transplantation; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods*; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
Photochemotherapie an tierexperimentellen Tumoren mit verschiedenen Photosensibilisatoren.