title: Effect of Trigonella foenum-graecum and Ammi majus on calcium oxalate urolithiasis in rats.
abstract: The present study was undertaken to investigate the effect of Trigonella foenum-graecum seed and Ammi majus fruit on experimentally-induced kidney stones. Oxalate urolithiasis in male rats was produced by the addition of 3% glycolic acid to their diet. After 4 weeks, highly significant deposition in the kidneys was noticed and changes in water intake and body weight recorded. Daily oral treatment with T. foenum-graecum significantly decreased the quantity of calcium oxalate deposited in the kidneys thus supporting its use in Saudi folk medicine. The effects obtained by A. majus were, however, not significant.
authors.affiliation: Research Centre, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors.forename: S K
authors.initials: SK
authors.lastname: Ahsan
authors.forename: M
authors.initials: M
authors.lastname: Tariq
authors.forename: A M
authors.initials: AM
authors.lastname: Ageel
authors.forename: M A
authors.initials: MA
authors.lastname: al-Yahya
authors.forename: A H
authors.initials: AH
authors.lastname: Shah
mesh_terms: D000818:Animals; D002129:Calcium Oxalate / Q000032:analysis; D006016:Glycolates; D008297:Male; D008519:Medicine, Traditional; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D014545:Urinary Calculi / Q000032:analysis / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D006016:Glycolates; C031149:glycolic acid; D002129:Calcium Oxalate