[Optical and electron microscopic study of the kidney of dogs naturally and experimentally infected with Leishmania (Leishmania) chagasi].
Two naturally infected dogs (male and female) from Teófilo Otoni (MG-Brazil) were maintained for 18 months in our laboratory. Two other dogs, two months old males were infected with 1 x 10(6) promastigotes of MHO/BR/70/BH46 Leishmania (Leishmania) chagasi strain, endovenous route, and autopsied after 10 months and two years. The main findings concerning the kidney were: (1) focal or diffuse mesangial glomerulonephritis with proliferative and enlargement of mesangial cells; (2) increase in thickness of basement membrane with electron-dense deposits; (3) chronic interstitial nephritis with intense exudation of plasmocytes; (4) cloud swelling of renal tubules. The authors discuss the probable pathogenetic mechanisms.
Tafuri
W L
WL
Michalick
M S
MS
Dias
M
M
Genaro
O
O
Leite
V H
VH
Barbosa
A J
AJ
Bambirra
E A
EA
da Costa
C A
CA
Melo
M N
MN
Mayrink
W
W
D000818:Animals; D004285:Dogs; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology*; D007668:Kidney / Q000473:pathology / Q000648:ultrastructure*; D007898:Leishmaniasis, Visceral / Q000150:complications*; D008297:Male; D009395:Nephritis, Interstitial / Q000209:etiology*
Estudo, ao microscópio óptico e eletrônico, do rim de cães natural e experimentalmente infectados com Leishmania (Leishmania) chagasi.