Owl monkey gene map: evidence for a homologous human chromosome 7q region near the cystic fibrosis locus.
We have demonstrated the assignments of two gene loci (COLIA2, MET) and two noncoding DNA markers (D7S13, D7S8) to owl monkey chromosome 14 (K-VI) by hybridizing DNA probes from the cystic fibrosis (CF) region of human chromosome 7q21-32 to panels of rodent-owl monkey somatic cell hybrids. The assignments are substantiated by in situ chromosome hybridization of markers COLIA2, MET, and D7S13 to the distal long arm of chromosome 14 (K-VI). These results support genomic conservation of the human CF region, at least in the higher primates.
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New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772.
Harris
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Watkins
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Tsui
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D000818:Animals; D001029:Aotus trivirgatus / Q000235:genetics*; D001483:Base Sequence; D015139:Blotting, Southern; D002427:Cebidae / Q000235:genetics*; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D003094:Collagen / Q000235:genetics*; D003550:Cystic Fibrosis / Q000235:genetics*; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D005260:Female; D015870:Gene Expression; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D011519:Proto-Oncogenes; D012689:Sequence Homology, Nucleic Acid
D015342:DNA Probes; D005819:Genetic Markers; D003094:Collagen; D004247:DNA