title: Gas chromatographic-mass spectrometric analysis of plasma nifedipine.
abstract: A gas chromatographic-mass spectrometric assay is described for the determination of plasma nifedipine using nitrendipine as an internal standard. Chromatographic separation was performed on a dimethylsilicone capillary column, and detection was by selected ion monitoring of electron impact-generated base peak ions. The lower limit of quantifiable detection of nifedipine was 2 ng/ml. The method was applied to plasma samples obtained from a human subject who had been dosed with a 10-mg nifedipine capsule every 8 h for eight doses.
authors.affiliation: Department of Medicinal Chemistry, College of Pharmacy, University of Tennessee, Memphis 38163.
authors.forename: K S
authors.initials: KS
authors.lastname: Patrick
authors.forename: E J
authors.initials: EJ
authors.lastname: Jarvi
authors.forename: A B
authors.initials: AB
authors.lastname: Straughn
authors.forename: M C
authors.initials: MC
authors.lastname: Meyer
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000097:blood* / Q000493:pharmacokinetics; D009568:Nitrendipine / Q000097:blood; D012015:Reference Standards
chemical_list: D009568:Nitrendipine; D009543:Nifedipine