[Action of trichlormethiazide and amiloride on cellular Na+, K+ and Mg+ concentrations].
While diuretic-induced changes of plasma electrolyte concentrations have often been described, comparatively few data exist on intracellular electrolyte concentrations under diuretic treatment. Therefore, we studied the effect on intracellular Mg2+, Na+ and K+ concentrations of a thiazide diuretic (trichlormethiazide 4 mg/d) in red blood cells of 14 patients with mild essential hypertension, and of a combination of a thiazide diuretic and a potassium-sparing diuretic (trichlormethiazide and amiloride 2 mg/d each) in red blood cells of 11 patients with mild essential hypertension. Measurements were performed by atomic absorption spectroscopy and flame photometry before starting treatment and after 4 and 8-12 weeks' diuretic treatment. There was no significant change in intracellular Na+ and K+ concentrations under either form of diuretic treatment. Intracellular Mg2+ concentrations decreased significantly under thiazide therapy, whereas there was a significant increase in intracellular Mg+ concentrations under thiazide and potassium-sparing combined diuretic therapy. The results show that the combination of a thiazide diuretic and a potassium-sparing diuretic is a useful means to avoid intracellular Mg2+ loss.
Kisters
K
K
Medizinische Universitäts-Poliklinik, Münster.
Zidek
W
W
Rahn
K H
KH
D000584:Amiloride / Q000494:pharmacology*; D004338:Drug Combinations; D004573:Electrolytes / Q000097:blood*; D004912:Erythrocytes / Q000032:analysis*; D006801:Humans; D008274:Magnesium / Q000097:blood; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013054:Spectrophotometry, Atomic; D014237:Trichlormethiazide / Q000494:pharmacology*
D004338:Drug Combinations; D004573:Electrolytes; D000584:Amiloride; D012964:Sodium; D008274:Magnesium; D014237:Trichlormethiazide; D011188:Potassium
Wirkung von Trichlormethiazid und Amilorid auf die zelluläre Na+-, K+- und Mg2+-Konzentration.