[The effect of imizin on the circadian rhythm of rat motor activity taking into account its administration schedules].
Chronic administration of imizine to rats irrespective of the administration schedule (once a day in the morning or in the evening in a dose of 10 mg/kg, twice a day in a dose of 5 mg/kg) changed the circadian rhythm of rest-activity with a shift of the acrophase at the late night hours. However at a single administration of the drug the effect occurred earlier than at its administration twice a day.
Baturin
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VA
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007099:Imipramine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D007099:Imipramine
Vliianie imizina na tsirkadiannyĭ ritm dvigatel'noĭ aktivnosti krys s uchetom razhimov ego vvedeniia.