title: Kinetics of amiloride in rat following oral and intravenous administration.
abstract: The disposition profile of amiloride, a potassium sparing agent, was studied in rats by using an HPLC method coupled to spectrofluorometric detection. Amiloride was administered orally and intravenously at the dose of 10 mg/Kg. The most relevant pharmacokinetic parameters are described for both administration routes.
authors.forename: F M
authors.initials: FM
authors.lastname: Runci
authors.forename: D
authors.initials: D
authors.lastname: Cerretani
authors.forename: E
authors.initials: E
authors.lastname: Bianchi
authors.forename: G
authors.initials: G
authors.lastname: Bruni
authors.forename: G
authors.initials: G
authors.lastname: Giorgi
mesh_terms: D000284:Administration, Oral; D000584:Amiloride / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000584:Amiloride