[Myopathy in the uremic patient: apropos of a case].
Uremic myopathy is relatively unknown, despite the fact that it can be quite a severe handicap. It is a non-specific proximal myopathy which must be distinguished from uremic polyneuropathy. Several disorders linked to renal insufficiency have been implicated, but these only play an adjuvant role with regard to renal osteodystrophy. Indeed the presence of myopathy in cases of severe osteodystrophy, its similarity to the myopathies associated with different types of osteomalacia and hyperparathyroidism without renal failure, suggest that the most important pathogenic factor is related to disorders of the calcium phosphate metabolism: excessive parathyroid hormone, vitamin D deficiency and/or impaired calcium transport. Treatment will depend on the predominant bone lesions: secondary hyperparathyroidism or osteomalacia. However prevention remains the best course.
Montagnac
R
R
Service de Néphrologie-Hémodialyse, CHG de Troyes.
Schillinger
F
F
Billaud
B
B
Monvoisin
G
G
Nollez
F
F
D000368:Aged; D002130:Calcium Phosphates / Q000378:metabolism; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000150:complications; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications* / Q000601:surgery; D009135:Muscular Diseases / Q000209:etiology* / Q000503:physiopathology; D006435:Renal Dialysis / Q000009:adverse effects*; D014511:Uremia / Q000150:complications* / Q000628:therapy; D014808:Vitamin D Deficiency / Q000150:complications
D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous
Myopathie chez l'urémique: à propos d'une observation.