Cerebral cortical concentrations of bioamines and their metabolites during arousal and after feeding in the little brown bat (Myotis lucifugus).
The concentrations of bioamines and their metabolites have been determined in March and April during arousal from hibernation in the cerebral cortex of the little brown bat (Myotis lucifugus). The patterns during arousal for dopamine and serotonin (5-HT) were similar with a significant fall in concentrations by 1 h of arousal, and an inverse relationship with their respective metabolites, 3,4-dihydroxyphenylacetic acid and 5-hydroxyindolacetic acid (5-HIAA). This suggests an acute release and metabolism of these bioamines with onset of arousal. During arousal, cerebral cortical concentrations of norepinephrine (NE) were not significantly changed. Levels of homovanillic acid were markedly depressed during hibernation and rose acutely with arousal. After arousal and 4 days of feeding in April, there was an increase in all bioamines and their metabolites studied except for NE. Of note is the marked decrease in the hibernating level of 5-HT and increase in its metabolite 5-HIAA from March to April, which may herald the natural termination of hibernation. Our results suggest that the brain of hibernators undergoes complex changes in the modulation of neurotransmitter systems which are consistent with both down- and up-regulation of neuronal activity in the maintenance of hibernation and the initiation of the arousal process.
Bauman
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WA
Solomon A. Berson Research Laboratory, Veterans Administration MedicalCenter, Bronx, NY 10468.
Hashim
A
A
Sershen
H
H
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism* / Q000502:physiology; D002685:Chiroptera / Q000378:metabolism* / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology*; D006605:Hibernation / Q000502:physiology*; D012621:Seasons
D001679:Biogenic Amines