Antipyretic activity of diacetyl para-amino phenol.
Diacetyl para-amino phenol (DAPAP) was generated by interaction between aspirin and paracetamol in a mechanical shaker. It revealed antipyretic activity in albino rats. The antipyretic action was found to be having the same onset of action and duration as that of aspirin. This compound lacked ulcerogenic and analgesic activity. DAPAP therefore may have safety as an antipyretic drug in patients with history of peptic ulcer.
Sewak
P
P
Department of Pharmaceutical Sciences, University of Nagpur.
Saxena
J
J
Dorle
A K
AK
Grover
J K
JK
D000082:Acetaminophen / Q000494:pharmacology / Q000633:toxicity; D000627:Aminophenols / Q000494:pharmacology* / Q000633:toxicity; D000700:Analgesics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity; D005260:Female; D008297:Male; D051379:Mice; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced
D000627:Aminophenols; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; C098626:4-diacetylaminophenol