Temporal parameters of cathinone, amphetamine and cocaine.
Rats were trained to discriminate intraperitoneally administered 0.8 mg/kg 1-cathinone from its vehicle in a two-lever operant procedure. The normal injection-to-session interval was fifteen minutes. When tested in session at 2-180 min postadministration, cathinone discrimination was seen to have a rapid onset (5 minutes) and offset (60 minutes). When the same rats were tested with either 0.8 mg/kg d-amphetamine or 10.0 mg/kg cocaine at the same postinjection time periods, the peak discriminative generalization to each of these other psychostimulants was observed to be later, i.e., an onset of action at 15-30 minutes with a slightly longer duration of action. The results indicate that cathinone exerts discriminative response control within five minutes of intraperitoneal injection and that it has a shorter duration than amphetamine and cocaine.
Schechter
M D
MD
Department of Pharmacology, Northeastern Ohio University, College of Medicine, Rootstown 44272.
D000470:Alkaloids / Q000494:pharmacology*; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004192:Discrimination, Psychological / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013647:Task Performance and Analysis; D013997:Time Factors
D000470:Alkaloids; D000662:Amphetamines; C023665:cathinone; D003042:Cocaine