[The anti-infective action of immunoglobulins administered at delayed times after irradiation].
In experiments with CBA and CBA X C57Bl(F-1) mice it was shown that the radio-protective efficacy and the anti-infectious influence of homo- and heterologous immunoglobulin (IG) applied one, two and three times in the period from 4h to 9 days following irradiation with doses of LD80-95/30. This was displayed by the increased survival rate and normalization of intestinal microflora in treated animals in comparison with untreated ones. Heterologous IG administered at varying times (5 to 20 days) after irradiation with the dose of 4.8 Gy increased the resistance of treated mice to infection with living E. coli culture.
Ulanova
A M
AM
Kuz'mina
T D
TD
Shal'nova
G A
GA
Bel'chenko
A N
AN
Korshunov
V M
VM
Ivanov
A A
AA
D000818:Animals; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control*; D002588:Cesium Radioisotopes; D005720:Gamma Rays; D007136:Immunoglobulins / Q000008:administration & dosage*; D051379:Mice; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000517:prevention & control*; D013997:Time Factors
D002588:Cesium Radioisotopes; D007136:Immunoglobulins
Antiinfektsionnoe deĭstvie immunoglobulinov v obluchennom organizme pri otsrochennom primenenii.