Platypnea-orthodeoxia and progressive autonomic failure.
Platypnea-orthodeoxia has been described in patients with pulmonary shunts, intracardiac shunts, and severe lung disease. We report a case of platypnea-orthodeoxia in a patient with minimal obstructive lung disease and progressive autonomic failure. We have shown our patient's symptoms to be the result of an orthostatic increase in ventilation-perfusion mismatching and to be corrected with fluid challenge.
Fox
J L
JL
Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland.
Brown
E
E
Harrison
J K
JK
Williams
J
J
Terry
P B
PB
D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000503:physiopathology; D004417:Dyspnea / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D011187:Posture
D010100:Oxygen