title: [Changes in the reaction of rat bone tissue to hypokinesia after administration of hydroxymethyl aminopropylidene bisphosphonate].
abstract: During 35-day hypokinesia rat spongy bone in the tibia and vertebrae varied in two phases. The first phase (up to 15 days) was induced by a stress-reaction and the second phase by adaptation to hypokinesia. Under the influence of subcutaneous injections of hydroxydimethyl aminopropylidene biphosphonate (AMOK) at a dose of 0.01 mg/kg/day bone changes disappeared: throughout the study spongy bone mass remained as in controls. AMOK administration at a dose of 5 mg/kg/day 10 days prior to hypokinetic exposure did not eliminate its inhibitory effect although the initial bone mass was 1.5-2 times higher than in the controls. However at the adaptation phase (beginning with day 15) bone mass increased, reaching the baseline. This indicates a decline in bone sensitivity to muscle unloading. It is concluded that AMOK modifies bone responses to various hypokinetic factors.
authors.forename: V N
authors.initials: VN
authors.lastname: Shvets
authors.forename: A S
authors.initials: AS
authors.lastname: Pankova
authors.forename: M D
authors.initials: MD
authors.lastname: Go'ldovskaia
authors.forename: Z E
authors.initials: ZE
authors.lastname: Vnukova
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects / Q000502:physiology*; D004164:Diphosphonates / Q000008:administration & dosage* / Q000494:pharmacology; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control*; D011602:Psychophysiologic Disorders / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology*; D013977:Tibia / Q000187:drug effects / Q000503:physiopathology; D013997:Time Factors
chemical_list: D004164:Diphosphonates; C055774:olpadronic acid
vernacular_title: Izmenenie reaktsii kostnoĭ tkani krys na gipokineziiu pod vliianiem oksidimetilaminopropiliden bisfosfonata (AMOK).