[Study of three barbiturate compounds using the Porsolt test].
The effects of newly synthetized hydroxylominic barbiturate NV-7, phenobarbital and pentobarbital, administered intraperitoneally, were studied on mice by the test of Porsolt. The obtained results were compared with the results, obtained by the test of rota-rod. There was prolongation of the time for immobility of the animals e.g. the effect of "despair" of the three examined barbiturates. The question is discussed whether the observed effect is due to the axyolytic action, established in the preceding experiments, or to the sedative and anticonvulsive actions of barbiturates, investigated before.
Getova
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D000818:Animals; D001463:Barbiturates / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D010424:Pentobarbital / Q000031:analogs & derivatives / Q000494:pharmacology / Q000633:toxicity; D010634:Phenobarbital / Q000494:pharmacology / Q000633:toxicity
D001463:Barbiturates; C056510:2-hydroxylamine-5-ethyl-5-sec-pentylbarbituric acid; D010424:Pentobarbital; D010634:Phenobarbital
Izsledvane na tri barbiturovi sŭedineniia po testa na Porsolt.