[The regulation of systemic and regional hemodynamics in waking rats with a chronic adriamycin-induced myocardial lesion].
Rats were given intraperitoneal injections of adriamycin (cumulative dose 20 mg/kg). Two weeks after the last injection left-ventricular function and systemic and regional hemodynamics were studied before and during isoprenaline infusion (0.64 mcg/kg/min) in conscious rats with no signs of cardiac insufficiency. In the controls isoprenaline increased the left-ventricular contractility index by 45% and the heart rate by 30%. The contractility index in rats given adriamycin did not change, the heart rate increased only by 14%, but in contrast to the controls, a significant increase of the cardiac index by 36% and diminution of total peripheral resistance by 36% were revealed. The sensitivity of the baroreflex chronotropic component in the control animals was twice that in the experimental rats. It is concluded that adriamycin cardiomyopathy in rats is attended by reduced sensitivity of the baroreflex mechanisms and diminished myocardial adrenergic reactivity.
Dugin
S F
SF
Gorodetskaia
E A
EA
Golikov
M A
MA
Medvedev
O S
OS
Kapel'ko
V I
VI
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002908:Chronic Disease; D004317:Doxorubicin / Q000633:toxicity*; D006333:Heart Failure / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D011877:Radionuclide Imaging; D051381:Rats; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D004317:Doxorubicin
Reguliatsiia sistemnoĭ i regionarnoĭ gemodinamiki u bodrstvuiushchikh krys s khronicheskim adriamitsinovym porazheniem miokarda.