Phenolsulfonphthalein pharmacokinetics and renal morphologic changes in adult pony mares with gentamicin-induced nephrotoxicosis.
Changes in renal function, determined by pharmacokinetics of phenolsulfonphthalein (PSP), and renal morphologic features were examined in adult pony mares given 20 mg of gentamicin sulfate/kg of body weight, IV, q 8 h (group A) n = 7 or isotonic saline solution, IV, q 8 h, n = 5 (group B) for 14 days. Susceptibility of ponies to gentamicin-induced nephrotoxicosis was varied. Two group-A ponies developed acute renal failure and were euthanatized before treatment day 14, whereas 5 group-A A ponies did not develop physical or behavioral abnormalities after 14 days of gentamicin administration. All group-A ponies but none of group-B ponies developed ultrastructural abnormalities of the proximal tubular epithelium, consistent with gentamicin-induced nephrotoxicosis. Significant (P less than 0.05) differences were not detected in pharmacokinetic values of either group. Clearance of PSP was reduced in 4 group-A ponies that developed the most severe gentamicin-induced nephrotoxicosis. Changes in clearance of PSP were significantly (P less than 0.05) correlated with changes in the serum creatinine concentration.
Hinchcliff
K W
KW
Department of Medical Science, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
McGuirk
S M
SM
MacWilliams
P S
PS
Cooley
A J
AJ
D000818:Animals; D004848:Epithelium / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D005839:Gentamicins / Q000633:toxicity*; D006736:Horses / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D009336:Necrosis; D010635:Phenolphthaleins / Q000493:pharmacokinetics*; D010637:Phenolsulfonphthalein / Q000493:pharmacokinetics*; D011897:Random Allocation
D005839:Gentamicins; D010635:Phenolphthaleins; D010637:Phenolsulfonphthalein