title: Circadian rhythmicity of plasma amino acid variations in healthy subjects.
abstract: The circadian periodicity of plasma amino acids (AA) was explored using Cosinor analysis. Six healthy subjects eating a standard diet (30 Kcal and 1 g of protein/Kg of body weight) were studied. Plasma samples for AA determination were taken at 07:00, 11:00, 15:00, 17:00, 21:00 and 24:00. The majority of AA showed an increment in the evening samples. This 24-h variability led to a circadian rhythmicity for all AA, except for taurine, threonine, glutamate, alanine, cystine, and total tryptophan. On average, the fluctuation was approximately 15% of the mesor and the acrophase timing was between 17:00 and 22:00.
authors.forename: O
authors.initials: O
authors.lastname: Riggio
authors.forename: M
authors.initials: M
authors.lastname: Merli
authors.forename: U
authors.initials: U
authors.lastname: Pièche
authors.forename: A
authors.initials: A
authors.lastname: Romiti
authors.forename: P
authors.initials: P
authors.lastname: Pasqualetti
authors.forename: A
authors.initials: A
authors.lastname: Coppola
authors.forename: D
authors.initials: D
authors.lastname: Danese
authors.forename: P
authors.initials: P
authors.lastname: Cugini
authors.forename: L
authors.initials: L
authors.lastname: Capocaccia
mesh_terms: D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000097:blood*; D002940:Circadian Rhythm; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000596:Amino Acids