title: Effect of a high dose of fluoride on resorbing osteoclasts in vivo.
abstract: Histomorphometric analysis of osteoclasts resorbing bone above the erupting first rat molar tooth germ was made at 1, 2, 6, 24, and 48 h following systemic administration of a single high dose of sodium fluoride. Compared to the number of osteoclasts in control rats, a significant reduction was observed in the number of actively resorbing osteoclasts in fluoride-injected rats at 2 and 6 h after dose administration, after which a gradual increase to control levels was observed. A locally increased number of inactive osteoclasts, not attached to bone surfaces, accompanied the reduced number of active osteoclasts.
authors.affiliation: Department of Histology & Neurobiology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Lindskog
authors.forename: M E
authors.initials: ME
authors.lastname: Flores
authors.forename: E
authors.initials: E
authors.lastname: Lilja
authors.forename: L
authors.initials: L
authors.lastname: Hammarström
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D010010:Osteoclasts / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D012969:Sodium Fluoride