[Peripheral nerve lesions of experimental leprosy in monkeys. VI. Tuberculoid leprous granuloma in an African green monkey].
Histopathological finding of left n. peroneus superficialis, left rami calcanei medialis (n. tibialis), left n. medianus, left ramus superficialis, n. radialis and left rami muscularis, m. palmaris brevis of african green monkey 8182 (Delta Regional Primate Research Center, USA) were studied by semithin section method. African green monkey 8182 was inoculated with leprosy bacilli isolated from lepromata of mangabey monkey A 015-natural infection. The length of period between date of inoculum and date of death of the monkey was about 5 years. 1. A typical tuberculoid leprous granuloma was observed in a fascicle of n. peroneus superficialis. 2. In the other fascicles of n. peroneus superficialis, proliferation of collagen fibers was remarkable not only at surrounding of myelinated nerve fibers but also at perineurium. Some of myelinated nerve fibers inside these fascicles were kept in good condition. 3. Infiltration of small amount of lymphocytes, proliferation of collagen fibers, and a few leprosy bacilli were observed inside some of fascicles of rami calcanei medialis. 4. In the fascicles of n. medianus, ramus superficialis of n. radialis and rami muscularis of n. ulnaris at m. palmaris brevis, proliferation of collagen fibres was observed not only at surrounding of myelinated nerve fibers but also at perineurium.
Fukunishi
Y
Y
D000818:Animals; D002522:Chlorocebus aethiops; D006099:Granuloma / Q000473:pathology*; D015441:Leprosy, Tuberculoid / Q000473:pathology*; D010525:Peripheral Nerves / Q000473:pathology*