Prevention of adverse effects of gamma-ray irradiation after metallothionein induction by bismuth subnitrate in mice.
The effect of preinduction of metallonthionein (MT) by bismuth subnitrate (BSN) on the adverse effects and antitumor activity of gamma-ray irradiation was investigated in mice. Preinduction of MT by oral administration of BSN significantly reduced the lethal effects and bone marrow injury caused by total body irradiation with gamma-rays. A significant increase in the MT concentration in bone marrow was observed in mice treated with BSN. In tumor-bearing mice, pretreatment with BSN did not compromise the antitumor activity of gamma-ray irradiation although bone marrow injury was remarkably suppressed. These results suggest that BSN pretreatment is an effective method for protection against side-effects in radiotherapy.
Satoh
M
M
Department of Public Health, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Miura
N
N
Naganuma
A
A
Matsuzaki
N
N
Kawamura
E
E
Imura
N
N
D000230:Adenocarcinoma / Q000532:radiotherapy; D000818:Animals; D001729:Bismuth / Q000494:pharmacology*; D001853:Bone Marrow / Q000528:radiation effects; D003110:Colonic Neoplasms / Q000532:radiotherapy; D005720:Gamma Rays / Q000009:adverse effects*; D007941:Leukemia P388 / Q000532:radiotherapy; D008297:Male; D008668:Metallothionein / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011839:Radiation, Ionizing
D008668:Metallothionein; C010804:bismuth subnitrate; D001729:Bismuth