Dimethyl cathate: synthesis and pharmacological investigation.
Dimethyl cathate was synthesized through a reaction sequence starting from 3,4-pyridinedicarboxylic acid anhydride, and hydrolyzed to the not yet described cathic acid. Pharmacological screening procedures only showed a protection against the convulsive effect of pentylenetetrazol.
Stein
M L
ML
Department of Pharmaceutical Studies, University of Rome La Sapienza, Italy.
Nencini
P
P
D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009539:Nicotinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control
D000700:Analgesics; D000927:Anticonvulsants; D009539:Nicotinic Acids; C063091:dimethyl cathate; D010433:Pentylenetetrazole