title: Leinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation.
abstract: Leinamycin (DC 107) is newly discovered antitumor antibiotic with an unusual 1,3-dioxo-1,2-dithiolane structure. Five different producing strains were isolated from soils collected in Japan during 1985-1988 and were taxonomically assigned as Streptomyces. Fermentation studies indicate: Leinamycin was unstable in culture broth. A chemically defined medium could be designed for a preferable production. Streptomyces sp. S-140 grew on medium supplemented with Zn2+ and high porus polymer resin and accumulated 32 micrograms/ml of leinamycin. Improved isolation methods are described along with identification of mikamycin A co-produced with leinamycin by the strain S-140.
authors.affiliation: Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: K
authors.initials: K
authors.lastname: Asano
authors.forename: I
authors.initials: I
authors.lastname: Kawamoto
authors.forename: T
authors.initials: T
authors.lastname: Takiguchi
authors.forename: S
authors.initials: S
authors.lastname: Katsumata
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Nakano
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D007769:Lactams; D018942:Macrolides; D013302:Streptomyces / Q000032:analysis; D013844:Thiazoles; D013871:Thiones
chemical_list: D000903:Antibiotics, Antineoplastic; D007769:Lactams; D018942:Macrolides; D013844:Thiazoles; D013871:Thiones; C059000:leinamycin