title: Erythromycin A oxime 11,12-carbonate and its oxime ethers.
abstract: Erythromycin A oxime 11,12-carbonate (5a) and its oxime ethers 5b approximately 5p have been prepared and their antibacterial activities compared with those of erythromycin A (1) and its 11,12-carbonate 2. The oxime 5a and many of its oxime ether derivatives showed good activity in vitro against Gram-positive and the more permeable Gram-negative organisms, in some cases being even more active than the carbonate 2.
authors.affiliation: Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Surrey, UK.
authors.forename: E G
authors.initials: EG
authors.lastname: Brain
authors.forename: A K
authors.initials: AK
authors.lastname: Forrest
authors.forename: E
authors.initials: E
authors.lastname: Hunt
authors.forename: C
authors.initials: C
authors.lastname: Shillingford
authors.forename: J M
authors.initials: JM
authors.lastname: Wilson
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004987:Ethers / Q000138:chemical synthesis* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D004987:Ethers; D010091:Oximes; C063102:erythromycin A oxime 11,12-carbonate; D004917:Erythromycin