title: Effects of non-Newtonian blood and metabolic states of the blood and vessel wall on the optimum design of single vessels and the vascular bifurcation.
abstract: Employing the optimality principle, we attempted to predict the effects of non-Newtonian blood and the metabolic states of individual vessel segments on the optimum vascular design. Our results implied that irrespective of the vessel caliber, the optimum flow rate of non-Newtonian blood through a cylindrical vessel is less than that of Newtonian blood by not more than some 12-13%, even though the non-Newtonian nature is within the pathologically-realistic highest range. Non-Newtonian blood does not exert the slightest degree of influence on the optimum geometry of the vascular bifurcation. In contrast, as the metabolic state of the vessel wall overwhelms that of the blood, the optimum flow through the cylindrical vessel becomes markedly increased: the optimum relative caliber of the branch of the bifurcation decreases and the optimum branching angle increases.
authors.affiliation: National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Oka
authors.forename: M
authors.initials: M
authors.lastname: Nakai
mesh_terms: D001769:Blood / Q000378:metabolism; D001783:Blood Flow Velocity; D001808:Blood Vessels / Q000033:anatomy & histology / Q000502:physiology*; D001809:Blood Viscosity; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D012212:Rheology