Campylobacter pylori and non-ulcer dyspepsia. 2. A prospective study in a Swedish population.
In a consecutive prospective series of 186 Swedish persons with the diagnosis of non-ulcer dyspepsia 71.5% were found to have gastritis and/or bulbar duodenitis in endoscopic biopsies. Gastroduodenitis was associated with campylobacter pylori (CP) in 83.5% of the cases. The double therapeutic approach using an antibiotic and a preparation containing bismuth in an uncontrolled therapeutic pilot trial resulted in improvement of the histological picture, disappearance of CP and amelioration of symptoms. It is concluded that CP-infection plays a central role in the pathogenesis of gastroduodenitis associated NUD.
Gad
A
A
Dept. of Clinical Pathology and Cytology, Falun Hospital, Sweden.
Hradsky
M
M
Furugård
K
K
Malmodin
B
B
Nyberg
O
O
D000328:Adult; D000536:Aluminum Hydroxide / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001729:Bismuth / Q000627:therapeutic use; D002167:Campylobacter / Q000302:isolation & purification; D002169:Campylobacter Infections / Q000188:drug therapy / Q000453:epidemiology*; D004338:Drug Combinations / Q000627:therapeutic use; D004415:Dyspepsia / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D004917:Erythromycin / Q000627:therapeutic use; D005260:Female; D006035:Glycyrrhiza; D006801:Humans; D008276:Magnesium Hydroxide; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use; D015995:Prevalence; D011446:Prospective Studies; D017693:Sodium Bicarbonate; D013548:Sweden / Q000453:epidemiology
D000897:Anti-Ulcer Agents; D004338:Drug Combinations; D010936:Plant Extracts; C002792:aluminum hydroxide, bismuth subnitrate, deglycyrrhizinised liquorice, magnesium carbonate, sodium bicarbonate drug combination; D000536:Aluminum Hydroxide; D004917:Erythromycin; D017693:Sodium Bicarbonate; D008276:Magnesium Hydroxide; D001729:Bismuth