title: Pyridazine analogues of biologically active compounds. Part 5: Novel potential cardiotonics of the amrinone type.
abstract: Preparation of a series of novel pyridazine derivatives structurally related to bipyridine cardiotonics, starting from 4-methylpyridazine or 4-acetylpyridazine, respectively, is described. As observed with compounds 8, 11 and 16, an enhancement of in vitro cardiotonic activity is associated with the replacement of one or both pyridine subunit(s) in amrinone or milrinone by a 1,2-diazine system.
authors.affiliation: Institute of Pharmaceutical Chemistry, University of Vienna, Austria.
authors.forename: N
authors.initials: N
authors.lastname: Haider
authors.forename: G
authors.initials: G
authors.lastname: Heinisch
authors.forename: S
authors.initials: S
authors.lastname: Offenberger
mesh_terms: D000676:Amrinone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D066298:In Vitro Techniques; D020105:Milrinone; D009200:Myocardial Contraction / Q000187:drug effects; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011728:Pyridones / Q000494:pharmacology
chemical_list: D002316:Cardiotonic Agents; D011724:Pyridazines; D011728:Pyridones; D020105:Milrinone; D000676:Amrinone