title: DOI is a mixed agonist-antagonist at postjunctional 5-HT2 receptors in the pithed rat.
abstract: The maximal pressor effect induced by DOI in the pithed rat was smaller than that induced by 5-HT, suggesting partial agonistic properties of DOI. DOI shifted the dose-pressor response curve of 5-HT to the right. It is concluded that, in addition to its 5-HT2 agonistic properties, DOI also possesses 5-HT2 antagonistic properties in the pithed rat.
authors.affiliation: INSERM U 228, Faculté de Médecine Broussais Hôtel-Dieu, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Dabiré
authors.forename: K
authors.initials: K
authors.lastname: Chaouche-Teyara
authors.forename: C
authors.initials: C
authors.lastname: Cherqui
authors.forename: B
authors.initials: B
authors.lastname: Fournier
authors.forename: H
authors.initials: H
authors.lastname: Schmitt
mesh_terms: D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003655:Decerebrate State; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists
chemical_list: D000662:Amphetamines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine