title: Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol.
abstract: The (-) enantiomer of gossypol but not the (+) enantiomer had good antiviral activity in peripheral blood mononuclear cells against human immunodeficiency virus type 1 at a concentration more than 20-fold lower than that required for cytotoxicity; however, in H9 cells the (-) enantiomer, although more potent as an antiviral agent, was more cytotoxic.
authors.affiliation: Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510.
authors.forename: T S
authors.initials: TS
authors.lastname: Lin
authors.forename: R
authors.initials: R
authors.lastname: Schinazi
authors.forename: B P
authors.initials: BP
authors.lastname: Griffith
authors.forename: E M
authors.initials: EM
authors.lastname: August
authors.forename: B F
authors.initials: BF
authors.lastname: Eriksson
authors.forename: D K
authors.initials: DK
authors.lastname: Zheng
authors.forename: L A
authors.initials: LA
authors.lastname: Huang
authors.forename: W H
authors.initials: WH
authors.lastname: Prusoff
mesh_terms: D002478:Cells, Cultured; D006072:Gossypol / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects; D013237:Stereoisomerism; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000494:pharmacology
chemical_list: D015215:Zidovudine; D006072:Gossypol