title: [Mechanism of the development of neuroparalytic keratitis].
abstract: There is a hypothesis that for appearance of the neuroparalytic keratitis a decisive role has cessation of discharge of trophic factors, demonstrating a polypeptide nature. from sensitive nervous endings. In order to check the hypothesis, deafferentation of the eye has been performed by means of electrocoagulation of the trigeminal sensitive nucleus in the medulla oblongata. Despite the fact that as a result of the operation connection of the sensitive cells with the periphery is preserved, the neuroparalytic keratitis occurs at the same time, as after sectioning the trigeminal nerve branching. The suggestion on excessive discharge of catecholamines from the sympathetic terminals as the cause of deafferentational disorders is not confirmed. The eye desympathization does not prevent appearance of the neuroparalytic keratitis. It is supposed that discontinue of information current to the center makes regulation of the peripheral tissues homeostasis impossible, that is the cause of the trophic disturbance.
authors.forename: G G
authors.initials: GG
authors.lastname: Kniazev
authors.forename: G B
authors.initials: GB
authors.lastname: Kniazeva
mesh_terms: D000818:Animals; D003315:Cornea / Q000294:innervation; D004564:Electrocoagulation / Q000009:adverse effects*; D005123:Eye / Q000294:innervation*; D005728:Ganglia, Sympathetic / Q000601:surgery*; D007634:Keratitis / Q000209:etiology*; D009886:Ophthalmoplegia / Q000209:etiology*; D051381:Rats; D014276:Trigeminal Nerve / Q000601:surgery*
vernacular_title: Mekhanizm vozniknoveniia neĭroparaliticheskogo keratita.