[Neuroleukemia in mice with leukemia L1210 treated with methotrexate].
Histological investigations were conducted in 33 methotrexate-treated mice with leukemia L1210. It has been found that in nonsuppressed systemic leukemia process the development and progressing of initial morphologic signs of neuroleukemia takes place as a result of perivascular growth of leukemic infiltrates from the bone marrow of the cranial and vertebral bones into the adjacent structures of the central nervous system.
Petrov
S A
SA
D000818:Animals; D004353:Drug Evaluation, Preclinical; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D009423:Nervous System Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000556:secondary*
D008727:Methotrexate
Neĭroleĭkoz u mysheĭ s leĭkozom L1210, lechennykh metotreksatom.