title: Influence of the ion-pair-formation on the pharmacokinetic properties of drugs. Part 5: Influence of ion-pair-formation on elimination of bretylium and hexylsalicylic acid in rats.
abstract: Following i.v. administration of the hydrophilic drug bretylium (1) and the lipophilic hexylsalicylic acid (2) in rats the plasma levels of 2 were increased due to an increased intestinal reabsorption of 2. Under these conditions the biliary eliminated amount of 2 was 8 times higher than that following the administration of 2 alone. The eneteroheptic circulation of 2 was found to be interrupted following i.v. administration of 1 and 2 and additional oral administration of an anionic exchanger. Then the plasma levels of 2 were not influenced by 1. On other hand the plasma levels of 2 appear to be too low in order to influence those of 1.
authors.affiliation: Sektion Pharmazie der Martin-Luther-Universität Halle, Jena.
authors.forename: R
authors.initials: R
authors.lastname: Neubert
authors.forename: C
authors.initials: C
authors.lastname: Hause
authors.forename: A
authors.initials: A
authors.lastname: Härtl
authors.forename: R
authors.initials: R
authors.lastname: Amlacher
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D001949:Bretylium Compounds / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012459:Salicylates / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D001949:Bretylium Compounds; D012459:Salicylates; C059285:3-hexylsalicylic acid