title: Efficacy of diclazuril in the control of intestinal coccidiosis in rabbits.
abstract: The anticoccidial efficacy of diclazuril was studied in rabbits artificially infected with Eimeria flavescens, Eimeria intestinalis, Eimeria magna and Eimeria perforans. Continuous administration at 1 and 2 ppm in pelleted feed proved to be highly efficacious in controlling oocyst output and faecal scores. The weight gain was comparable and the feed efficiency slightly improved compared with the non-infected, non-medicated controls, and clinical signs were fully prevented. Medication of rabbits at 0.5 ppm also provided a significant improvement in all parameters compared with the infected, non-medicated controls. In order to obtain 100% effectiveness in the control of intestinal coccidiosis in rabbits, continuous medication at 1 ppm is recommended.
authors.affiliation: Janssen Pharmaceutica, Beerse, Belgium.
authors.forename: O
authors.initials: O
authors.lastname: Vanparijs
authors.forename: L
authors.initials: L
authors.lastname: Desplenter
authors.forename: R
authors.initials: R
authors.lastname: Marsboom
mesh_terms: D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D003048:Coccidiosis / Q000517:prevention & control / Q000662:veterinary*; D003049:Coccidiostats / Q000008:administration & dosage / Q000627:therapeutic use*; D007411:Intestinal Diseases, Parasitic / Q000517:prevention & control / Q000662:veterinary*; D009570:Nitriles / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits / Q000469:parasitology*; D011897:Random Allocation; D014227:Triazines / Q000008:administration & dosage / Q000627:therapeutic use*; D015430:Weight Gain
chemical_list: D003049:Coccidiostats; D009570:Nitriles; D014227:Triazines; C057884:diclazuril