N-(2-mercaptopropionyl)-glycine inhibits chemiluminescence and accelerates phagocytosis in human polymorphonuclear leukocytes.
Treatment of polymorphonuclear leukocytes with the soluble and cell penetrating thiol N-(2-mercaptopropionyl)-glycine (2-MPG) inhibits luminol-enhanced chemiluminescence induced by opsonized zymosan, which is believed to be a measure for the generation of reactive oxygen species, and accelerates the rate of phagocytosis measured as ingestion of zymosan particles. It is discussed that 2-MPG protects the phagocyting cells from oxidative damage by reactive oxygen species that are formed during particle ingestion.
Lösche
W
W
Institute of Pathological Biochemistry, Medical Academy of Erfurt, GDR.
Michel
E
E
Krause
S
S
Pescarmona
G P
GP
Till
U
U
D006801:Humans; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*; D008625:Tiopronin / Q000494:pharmacology*
D008625:Tiopronin