[Clearance of oxypurines and uric acid in patients with gout].
The clearance of uric acid, hypoxanthine and xanthine has been examined in gouty patients and in normal subjects comparatively to the creatinine clearance. The clearance of the three purine compounds was lower in the gouty patients, while the creatinine clearance showed a normal behavior. These results indicate that either the tubular excretion or the carriers of the considered metabolites probably undergo specific alterations in the gout.
Vannoni
D
D
Porcelli
B
B
Di Stefano
A
A
Pizzichini
M
M
Leoncini
R
R
Terzuoli
L
L
Taddeo
A
A
Marsini
S
S
Morozzi
G
G
Marcolongo
R
R
D000328:Adult; D005260:Female; D006073:Gout / Q000378:metabolism*; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D014527:Uric Acid / Q000493:pharmacokinetics*; D019820:Xanthine; D014970:Xanthines / Q000493:pharmacokinetics*
D007042:Hypoxanthines; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine
Clearance delle ossipurine e dell'acido urico in soggetti gottosi.