Severe complication to phytomenadione after intramuscular injection in woman in labor. Case report and review of literature.
A 28-year-old woman in labor developed a severe anaphylactoid reaction, necessitating acute cesarean section, with subsequent neonatal death, after receiving 10 mg of phytomenadione (Konakion) by the intramuscular route. Allergologic investigations revealed no type I reaction against the drug, and the symptoms were considered to be caused by drug-induced intolerance. Prophylactic administration of phytomenadione to the infant rather than to the parturient is recommended.
Anderson
T H
TH
Department of Respiratory Medicine, Aalborg Hospital South, Denmark.
Hindsholm
K B
KB
Fallingborg
J
J
D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000401:mortality / Q000517:prevention & control; D007273:Injections, Intramuscular; D008297:Male; D011247:Pregnancy; D010837:Vitamin K 1 / Q000008:administration & dosage / Q000009:adverse effects*
D010837:Vitamin K 1