title: [Various features of the initial stages of assimilation of isotope-labelled dipeptide].
abstract: Tritium-labeled dipeptide Gly-Leu was administered to noninbred guinea pigs by intracardiac injections, and to Wistar rats--intra-intestinally, through a specially implanted catheter. It was found that after intravenous and intraintestinal administration of isotope-labeled dipeptide the "low-molecular label" was bound by serum proteins. Dissociation of the complexes "low-molecular label"--serum protein in 8 M solution of urea has evidenced a predominantly reversible character of interaction between the low-molecular ligand and protein macromolecule. The results obtained should be taken into consideration during assay of protein absorption from gastro-intestinal tract of laboratory animals.
authors.forename: N F
authors.initials: NF
authors.lastname: Samenkova
authors.forename: L F
authors.initials: LF
authors.lastname: Poriadkov
authors.forename: L E
authors.initials: LE
authors.lastname: Vega-Matamoros
authors.forename: O N
authors.initials: ON
authors.lastname: Klimzo
authors.forename: V K
authors.initials: VK
authors.lastname: Mazo
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage / Q000378:metabolism*; D004151:Dipeptides / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D006168:Guinea Pigs; D007553:Isotope Labeling; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium
chemical_list: D001798:Blood Proteins; D004044:Dietary Proteins; D004151:Dipeptides; D014316:Tritium
vernacular_title: Nekotorye osobennosti nachal'nykh étapov usvoeniia izotopno-mechennogo dipeptida.