[Cytotoxin adhesion and invasiveness of Campylobacter jejuni from children with diarrhea: assay and correlation with clinical manifestations].
Some potentially pathogenic properties have been identified for Campylobacter jejuni in vitro. The cell-free filtrates of 42 strains, (28 isolated from clinical cases of diarrhea, 12 from domestic animals and 2 from healthy children) were investigated. 30 of the 42 were cytotoxin producers, and the strains from clinical cases were more frequent than those from other sources (P less than 0.05). Meanwhile, 25 of the 42 strains exhibited adhesion and invasiveness with HeLa cell line in vitro. It is surprising that the 2 strains from healthy children were all negative in cytotoxin production, adhesion and invasiveness in vitro. Analysis of the virulence correlation with clinical manifestations indicated that the pathogenic significance of cytotoxin, adhesion and invasiveness should be adequately evaluated.
Sun
Z J
ZJ
Duan
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D000818:Animals; D001422:Bacterial Adhesion; D002168:Campylobacter fetus / Q000302:isolation & purification / Q000472:pathogenicity*; D002648:Child; D002675:Child, Preschool; D003603:Cytotoxins / Q000032:analysis; D003967:Diarrhea / Q000382:microbiology*; D006801:Humans; D007223:Infant; D014774:Virulence
D003603:Cytotoxins