The antiallatal effects on locusts and lethal effects on nematodes of synthetic precocene-1 derivatives differing at the carbon 7 position.
Fourteen precocene-1 (P1) derivatives differing at C-7 were synthetized and tested for their antiallatal activities on Locusta migratoria (in vitro and in vivo) and nematocidal effects on Caenorhaditis elegans. An outstanding antiallatal effect was produced by 7-propargyloxy-P1 in vitro. It caused an elevated rate of mortality when applied in vivo to locusts or nematodes. The antiallatal effect of 7-cyclopentyloxy-P1 was not accompanied by toxicity. Aralkyloxy substitution at C-7 eliminated the precocene activity.
Fodor
A
A
Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, Szeged.
Deák
P
P
Berényi
M
M
Timár
T
T
Hosztafi
S
S
Kiss
I
I
D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D002107:Caenorhabditis / Q000187:drug effects*; D006110:Grasshoppers / Q000187:drug effects* / Q000254:growth & development; D007605:Juvenile Hormones / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
D001578:Benzopyrans; D007605:Juvenile Hormones; C019539:precocene I