HLA association of anti-IgA antibody production.
We have HLA typed 46 unrelated IgA deficient blood donors in our region. A weak association to DR3 (RR = 2.07) was observed. However, owing to the heterogeneous nature of this group, we found DR7 may be associated with those who developed class-specific anti-IgA antibodies (RR = 2.94), whereas DR1 may be associated with those who did not (RR = 2.42).
Strothman
R A
RA
American Red Cross Blood Services, Fort Wayne Region, Indiana.
Sedestrom
L M
LM
Ball
M J
MJ
Chen
S N
SN
D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis*; D004406:Dysgammaglobulinemia / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis*; D015798:HLA-DR1 Antigen / Q000032:analysis; D015803:HLA-DR3 Antigen / Q000032:analysis; D015809:HLA-DR7 Antigen / Q000032:analysis; D006801:Humans; D017098:IgA Deficiency; D007070:Immunoglobulin A / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D015803:HLA-DR3 Antigen; D015809:HLA-DR7 Antigen; D007070:Immunoglobulin A