Identification of meso-hydroxyuroporphyrin I in the urine of a patient with congenital erythropoietic porphyria.
A new porphyrin, meso-hydroxyuroporphyrin I, was isolated from the urine of a patient with congenital erythropoietic porphyria. The structure was characterized as the methyl ester, ethyl ester and acetoxy derivatives by fast-atom-bombardment m.s., by conversion into uroporphyrin I and by chemical synthesis.
Guo
R
R
Division of Clinical Cell Biology, M.R.C. Clinical Research Centre, Harrow, Middx., U.K.
Rideout
J M
JM
Lim
C K
CK
D000293:Adolescent; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D011164:Porphyrias / Q000235:genetics / Q000652:urine*; D011166:Porphyrins / Q000652:urine*; D014578:Uroporphyrins / Q000652:urine*
D011166:Porphyrins; D014578:Uroporphyrins; C062206:hydroxyuroporphyrin I