title: Single-dose ciprofloxacin in the treatment of uncomplicated urinary tract infection in women.
abstract: In a randomised, double-blind trial two single-dose regimens of ciprofloxacin were evaluated for treatment of acute urinary tract infection (UTI) in women. Fifty-three women received 250 mg and 46 750 mg of ciprofloxacin. Seven days after treatment the eradication rate was 81.1% and 82.6% in the low and high dose groups respectively; the clinical cure rate at 28 days was 64.1% and 73.9% respectively. In women with recurrent UTI a significantly better response was found with the high dose regimen (92% versus 68%; p less than 0.001). It is concluded that a single 250 mg dose of ciprofloxacin is effective for treatment in most women with acute UTI, but in women with recurrent infection a 750 mg dose is preferable.
authors.affiliation: Infectious Diseases Unit, Central Emek Hospital, Afula, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Raz
authors.forename: E
authors.initials: E
authors.lastname: Rottensterich
authors.forename: H
authors.initials: H
authors.lastname: Hefter
authors.forename: Y
authors.initials: Y
authors.lastname: Kennes
authors.forename: I
authors.initials: I
authors.lastname: Potasman
mesh_terms: D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D008875:Middle Aged; D011897:Random Allocation; D012008:Recurrence; D013997:Time Factors; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D002939:Ciprofloxacin