title: [Electrophysiologic effects of intravenous digoxin in infants and children with Wolff-Parkinson-White syndrome].
abstract: Electrophysiologic properties of the accessory pathway were investigated before and after the intravenous administration of digoxin (0.01-0.02 mg/kg) during electrophysiologic studies in 14 infants and children with the Wolff-Parkinson-White syndrome. Determination of electrophysiologic properties of the accessory pathway was made using transesophageal atrial pacing and/or intracardiac right atrial pacing. Maximal effect on the accessory pathway after intravenous digoxin was observed during one to six hours. Effective refractory period of the accessory pathway increased in 6 of the 14 patients, decreased in 4 and unchanged in 4. Shortest AP 1:1 conduction increased in 5 of the 12 patients, decreased in 3 and unchanged in 4. Tachycardia was not induced after digoxin in only one patient. Tachycardia cycle length, ventriculoatrial conduction time and atrioventricular conduction time were unchanged after digoxin in almost all cases. Thus, digoxin is not the first choice drug for termination and prevention of the preexcitation syndrome.
authors.forename: Y
authors.initials: Y
authors.lastname: Fujiseki
authors.forename: F
authors.initials: F
authors.lastname: Hidetoshi
authors.forename: N
authors.initials: N
authors.lastname: Umemura
authors.forename: S
authors.initials: S
authors.lastname: Nishijima
authors.forename: M
authors.initials: M
authors.lastname: Hattori
authors.forename: M
authors.initials: M
authors.lastname: Shimada
authors.forename: T
authors.initials: T
authors.lastname: Sugiyama
authors.forename: R
authors.initials: R
authors.lastname: Nishikawa
authors.forename: N
authors.initials: N
authors.lastname: Kiyosawa
authors.forename: R
authors.initials: R
authors.lastname: Mizuta
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002304:Cardiac Pacing, Artificial; D002648:Child; D002675:Child, Preschool; D004077:Digoxin / Q000008:administration & dosage / Q000494:pharmacology*; D004594:Electrophysiology; D005260:Female; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D008297:Male; D014927:Wolff-Parkinson-White Syndrome / Q000503:physiopathology*
chemical_list: D004077:Digoxin