Dantrolene suppresses the hyperpolarization or outward current observed during anoxia in hippocampal neurons.
Hyperpolarizations, or outward currents, recorded in CA1 pyramidal cells during brief anoxia (2-3 min) (but not postanoxic hyperpolarizations) are markedly reduced (92 +/- 4.8%) by dantrolene sodium, applied by superfusion (10-20 microM). This effect, which is at least partly reversible by prolonged washing, is in keeping with the idea that anoxia activates a Ca2(+)-sensitive K conductance by releasing Ca2+ from internal stores.
Krnjević
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Anaesthesia Research Department, McGill University, Montréal, Québec, Canada.
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D000818:Animals; D002118:Calcium / Q000502:physiology; D015687:Cell Hypoxia; D003620:Dantrolene / Q000494:pharmacology*; D006624:Hippocampus / Q000502:physiology; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats
D003620:Dantrolene; D002118:Calcium