[Acceleration of the healing of burn wounds in mice under the influence of alpha 1-acid glycoprotein].
The effect of alpha 1-acid glycoprotein (alpha 1-AGP) was tested in experiments on rats with thermal burns. For comparison control mice with burns were given injections of albumin, physiological solution or did not receive injections. alpha 1-AGP was administered in the first 2 days after the burn to a total dose of 6 mg. Injection of physiological solution, alpha 1-AGP and albumin reduced animal lethality in the stage of shock. The burn disease took a more favourable course in patients given alpha 1-AGP than in those who received physiological solution and albumin. This was manifested by more rapid healing of the burn wounds and lower incidence of complications of burn disease. The possible mechanisms of the therapeutic action of alpha 1-AGP are discussed.
Salomatin
V V
VV
Sobolevskaia
T M
TM
Kurilova
T V
TV
Lifshits
R I
RI
D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D004353:Drug Evaluation, Preclinical; D005260:Female; D051379:Mice; D009961:Orosomucoid / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000503:physiopathology; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology; D014946:Wound Infection / Q000188:drug therapy / Q000503:physiopathology
D009961:Orosomucoid
Uskorenie zazhivleniia ozhogovykh ran u mysheĭ pod vliianiem al'fa 1-kislogo glikoproteida.