[Comparison of the methods of in vitro evaluation of the neutralizing properties of drugs from the antacid group].
Usefulness of the pH-stat method for assaying the neutralizing activity of antacids was compared with the ones of the methods based on the determination of the action time by dynamic methods. A high level of correlation between the antacid dose and the neutralization capacity has been stated. The found relationships proved to enable optimization of the antacid dosage as well as prediction of the therapeutic effect.
Pawlaczyk
J
J
Kokot
Z
Z
Urbowicz
G
G
Ewertowska
D
D
D000863:Antacids / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006851:Hydrochloric Acid / Q000037:antagonists & inhibitors*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008722:Methods; D013997:Time Factors
D000863:Antacids; D006851:Hydrochloric Acid
Porównanie metod oceny in vitro właściwości zobojetniajacych preparatów z grupy antacida.