Creatine-kinase-BB after severe head-injury as an index of prognosis in relation to nature of trauma and patients age.
Creatine-Kinase-BB (CK-BB) is a brain specific enzyme, with a prognostic value for the patient's outcome after head-injury. We have investigated 76 brain injured patients and attempted to show a correlation of the concentrations of CK-BB and the Glasgow-Outcome-Scale (GOS). Patients with a CK-BB concentration of more than 50 ng/ml died. Patients, who had a CK-BB concentration less than 25 ng/ml showed only minimal neurological deficits. Intracerebral contusions and acute subdural haematomas showed the highest CK-BB concentration, indicating a high degree of braintissue-damage. CK-BB seems to have no correlation with the age of patients. Normalisation of elevated CK-BB levels do not correlate with recovery from neurological deficit.
Niedeggen
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A
Department of Neurosurgery, RWTH Aachen, Federal Republic of Germany.
Adelt
D
D
Berndt
R
R
Hopf
T
T
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001930:Brain Injuries / Q000150:complications / Q000201:enzymology* / Q000503:physiopathology; D003402:Creatine Kinase / Q000378:metabolism*; D005260:Female; D006407:Hematoma, Epidural, Cranial / Q000150:complications / Q000201:enzymology / Q000503:physiopathology; D006408:Hematoma, Subdural / Q000150:complications / Q000201:enzymology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged
D003402:Creatine Kinase