Histamine effects on pulmonary blood vessels in strangulation.
Endothelial cells of asphyxial pulmonary veins possess abundant pores and intracytoplasmic vacuoles. The present radioassay demonstrated an increase in histamine concentrations of the pulmonary tissue in asphyxia. These morphological changes, therefore, appear to represent an enhancement of the endothelial permeability induced by high histamine concentrations in blood plasma. The present immunoelectron microscopy study demonstrated heavy reactions of histamine exclusively on the endothelial surface of the asphyxial pulmonary veins. This may support the endothelial cell-dependent vasodilation mediated by histamine in asphyxial pulmonary veins.
Kita
T
T
Department of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Furuya
Y
Y
D000818:Animals; D001237:Asphyxia / Q000473:pathology*; D002199:Capillary Permeability / Q000502:physiology; D004730:Endothelium, Vascular / Q000473:pathology; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism*; D008297:Male; D008855:Microscopy, Electron, Scanning; D011652:Pulmonary Circulation / Q000502:physiology*; D011667:Pulmonary Veins / Q000473:pathology
D006632:Histamine