title: [Antigenic variability of avian influenza virus A/H13, isolated in the USSR].
abstract: The antigenic structure of influenza H13 viruses isolated from wild birds in the USSR in 1976-1985 was studied. Antiserum against the reference A/gull/Maryland/704/77 (H13N6) strain was used to demonstrate the antigenic variations among the viruses. The homology of nucleotide sequences in the region 99-215 for the two A/H13N6 strains, A/gull/Maryland/704/77 and A/great black-headed gull/Astrakhan/227/84, were 75% and 86%, respectively. The 9-base segment deletion in A/grey black-headed gull/Astrakhan/277/84 was observed. Comparison of the predicted amino acid sequences of the strains' hemagglutinin in the appropriate region (amino acids 2-40) revealed 5 replacements (86% homology). Two replacements of arginine by lysine and asparagine by serine in positions 15 and 16, respectively, are the most significant. The latter replacement is accompanied by a change in the glycosylation site and might alter its three-dimensional structure. Further studies of the isolate genome are under way.
authors.forename: S S
authors.initials: SS
authors.lastname: Iamnikova
authors.forename: T O
authors.initials: TO
authors.lastname: Kovtun
authors.forename: G A
authors.initials: GA
authors.lastname: Dmitriev
authors.forename: I G
authors.initials: IG
authors.lastname: Shemiakin
authors.forename: N P
authors.initials: NP
authors.lastname: Semenova
authors.forename: D K
authors.initials: DK
authors.lastname: L'vov
authors.forename: T
authors.initials: T
authors.lastname: Chambers
authors.forename: R
authors.initials: R
authors.lastname: Vebster
mesh_terms: D000595:Amino Acid Sequence; D000940:Antigenic Variation; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology*; D001483:Base Sequence; D006389:Hemagglutinins, Viral / Q000235:genetics; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology*; D008969:Molecular Sequence Data; D011863:Radioimmunoassay; D012689:Sequence Homology, Nucleic Acid; D014764:Viral Proteins / Q000032:analysis
chemical_list: D000956:Antigens, Viral; D006389:Hemagglutinins, Viral; D014764:Viral Proteins
vernacular_title: Antigennaia varibel'nost' virusov grippa ptits A/H13, izolirovannykh v SSSR.