The effect of ethanol on the antiarrhythmic action of atenolol.
The effect of ethyl alcohol on the antiarrhythmic action of atenolol in the adrenaline-induced arrhythmia model was studied in rats non-dependent and dependent on ethanol. Atenolol administered jointly with ethanol, in a single dose or repeatedly produced a weaker antiarrhythmic effect than when it was given alone. Moreover, a rise in animal mortality was observed, in particular after atenolol administration in the period of intoxication. No significant effect of atenolol on ethanol blood concentration was found.
Filipek
B
B
Department of Pharmacodynamics, Medical Academy, Podchorazych, Kraków, Poland.
Krupińska
J
J
Librowski
T
T
Zebala
K
K
Piasecka
I
I
Piekoszewski
W
W
D000284:Administration, Oral; D000437:Alcoholism / Q000503:physiopathology; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology; D001262:Atenolol / Q000494:pharmacology*; D004347:Drug Interactions; D004837:Epinephrine; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000889:Anti-Arrhythmia Agents; D000431:Ethanol; D001262:Atenolol; D004837:Epinephrine