title: Two subpopulations of patients with early and late onset of psoriasis differ regarding alpha 1-proteinase inhibitor activity.
abstract: Two subpopulations of patients with psoriasis were identified when activity of alpha 1-proteinase inhibitor was analysed according to the patient's age at onset of the disease. Patients with early onset had more active lesions, high incidence of familial psoriasis, and reduced alpha 1-proteinase inhibitor during flare similar to that activity in remission. In contrast, alpha 1-proteinase activity increased significantly during flare in patients with late onset (above 21 yrs of age) in response to the inflammatory process in the psoriatic skin.
authors.affiliation: Department of Dermatology, Academy of Medicine, Warsaw, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Glinski
authors.forename: D
authors.initials: D
authors.lastname: Barszcz
authors.forename: M
authors.initials: M
authors.lastname: Glinska-Ferenz
authors.forename: Z
authors.initials: Z
authors.lastname: Zarebska
authors.forename: S
authors.initials: S
authors.lastname: Jablonska
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000166:cytology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology; D011565:Psoriasis / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D000515:alpha 1-Antitrypsin / Q000032:analysis / Q000096:biosynthesis / Q000378:metabolism*
chemical_list: D000515:alpha 1-Antitrypsin