Immune responses following killed whole vibrio-B subunit oral cholera vaccine in human volunteers.
Immunogenicity of killed whole vibrio and B subunit oral cholera vaccines in American and Thai volunteers were analysed in terms of significant rise of antibody titre. Three doses of 2 x 10(11) killed vibrios and 5 mg of cholera toxin B subunit were given at two-week intervals. There were no differences in the percent of volunteers with significant rise of serum immunoglobulin G and secretory immunoglobulin A (sIgA) to cholera toxin. However, the percent with significant rises of serum antibody to whole cell V. cholerae Inaba measured by vibriocidal titre and serum immunoglobulin G, and secretory immunoglobulin A to lipopolysaccharide (LPS) measured by ELISA in American volunteers were significantly different from those in Thai volunteers (89% VS 45%, 68% VS 9% and 53% VS 0%, respectively) (p less than 0.05).
Pitisuttithum
P
P
Vaccine Trial Centre, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Migasena
S
S
Suntharasamai
P
P
Supanaranond
W
W
Desakorn
V
V
Prayurahong
B
B
D000284:Administration, Oral; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D001459:Bangladesh / Q000453:epidemiology; D002771:Cholera / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control; D022121:Cholera Vaccines / Q000008:administration & dosage*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D015164:Vaccines, Inactivated / Q000008:administration & dosage
D000907:Antibodies, Bacterial; D022121:Cholera Vaccines; D007074:Immunoglobulin G; D015164:Vaccines, Inactivated