[123I-IMP-SPECT finding of a case of presenile dementia with motor neuron disease--comparison between Alzheimer's disease, Pick's disease and presenile dementia with motor neuron disease].
Cross-sectional X-CT and 123I-IMP-SPECT studies comparing patients with presenile dementia with motor neuron disease (52-year-old, female), with Alzheimer's disease (51-year-old, male) and Pick's disease (49-year-old, male), have found a pattern of reductions in regional cerebral blood flow; the most severe reductions have been in fronto-temporal regions in cases of Pick's disease and presenile dementia with motor neuron disease. 123I-IMP-SPECT in a patient with presenile dementia with motor neuron disease differed significantly from uptake in a case with Alzheimer's disease. Although these findings should be evaluated as part of a prospective longitudinal study with X-CT and 123I-IMP-SPECT, it could be suggested that the development of these diseases has different pathophysiologies.
Mitsuyama
Y
Y
D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging; D003704:Dementia / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons; D009468:Neuromuscular Diseases / Q000150:complications*; D015899:Tomography, Emission-Computed, Single-Photon
D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine