Processing of the polymeric immunoglobulin receptor.
The transcellular transport of polymeric immunoglobulins (pIg) across mucosal epithelia is mediated by a membrane glycoprotein known as the polymeric immunoglobulin receptor (pIgR). The intracellular routing of the pIgR has been used as a model to study protein traffic. Examination of the biosynthesis and processing of the pIgR in mammary gland and liver have led to a working hypothesis for pIgR routing in the cell. These hypotheses are currently being tested in an immortalized cell line derived from rabbit mammary gland alveolar cells.
Solari
R
R
Institut Suisse de Recherches Experimentales sur le Cancer, Epalinges, Switzerland.
Schaerer
E
E
Tallichet
C
C
Racine
L
L
Kraehenbuhl
J P
JP
D000818:Animals; D001693:Biological Transport, Active; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D007070:Immunoglobulin A / Q000378:metabolism*; D007700:Kinetics; D010766:Phosphorylation; D011817:Rabbits; D051381:Rats; D011971:Receptors, Immunologic / Q000378:metabolism*; D012635:Secretory Component
D007070:Immunoglobulin A; D011971:Receptors, Immunologic; D012635:Secretory Component; C034639:polymeric IgA