[Determination of the activity of neurotoxic esterase in the peripheral blood lymphocytes for assessing the action of organophosphorus compounds].
It was shown on a model of intoxication of hens with aphos possessing a selective neuroparalytic action that the target-enzyme neurotoxic esterase changed its activity in the brain, spleen and lymphocytes of the peripheral blood. The authors describe a method of determination of the activity of neurotoxic esterase in human peripheral blood lymphocytes that may be used for biomonitoring of the effect of phosphorus organic compounds possessing a delayed neurotoxic action.
Tkachenko
I I
II
Kokshareva
N V
NV
Zinchenko
D V
DV
Zinov'eva
M L
ML
Kagan
Iu S
IuS
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors / Q000097:blood*; D002645:Chickens; D005260:Female; D006801:Humans; D007306:Insecticides / Q000633:toxicity*; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology; D009943:Organophosphorus Compounds / Q000633:toxicity; D013154:Spleen / Q000187:drug effects / Q000201:enzymology
D007306:Insecticides; D009943:Organophosphorus Compounds; C034223:aphos; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase
Opredelenie aktivnosti neĭrotoksicheskoĭ ésterazy v limfotsitakh perifericheskoĭ krovi dlia otsenki deĭstviia fosfororganicheskikh soedineniĭ.