Continuous parenteral infusion of vitamin E pharmacokinetics and bilirubin production in premature neonates.
We conclude that 5 mg/kg of vitamin E, administered intra-arterially as an 8-hour continuous infusion, significantly and predictably raises serum vitamin E levels into the supraphysiologic range with no apparent side effects. In a group of premature infants whose initial serum vitamin E levels were generally greater than or equal to 0.5 mg/dL, no decrease in bilirubin production was observed. Thus, vitamin E deficiency probably does not play a prominent role in jaundice of prematurity.
Stevenson
D K
DK
Department of Pediatrics, Stanford University School of Medicine, California 94305.
Vreman
H J
HJ
Ferguson
J E
JE
Lenert
L A
LA
Leonard
M B
MB
Gale
R
R
D001663:Bilirubin / Q000096:biosynthesis*; D002263:Carboxyhemoglobin / Q000378:metabolism; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D007263:Infusions, Parenteral; D008297:Male; D014810:Vitamin E / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology
D006454:Hemoglobins; D014810:Vitamin E; D002263:Carboxyhemoglobin; D001663:Bilirubin