[Derivatives of daunorubicin containing an inosine fragment].
Condensation of daunorubicin or its (13 R, S)-dihydro derivative with inosine dialdehyde in the presence of NaBH3CN yielded novel derivatives of anthracycline antibiotics with incorporated inosine residue: 3'-deamino-3'-[(2" R)-(hypoxanthyl-9)-(6" S)-hydroxymethylmorpholino-N4"]- daunorubicin and (13 R,S)-dihydro-3'-deamino-3'-[(2" R)-(hypoxanthyl-9)-(6" S)- hydroxymethylmorpholino-N4"]-daunorubicin. The compounds did not inhibit growth of Bacillus mycoides and were less cytotoxic in vitro and less toxic in vivo than the parent antibiotics.
Olsuf'eva
E N
EN
Todorova
N P
NP
Iartseva
I V
IV
Rozynov
B V
BV
Shepelevtseva
N G
NG
Preobrazhenskaia
M N
MN
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001407:Bacillus / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000494:pharmacology; D007288:Inosine; D009682:Magnetic Resonance Spectroscopy
D000903:Antibiotics, Antineoplastic; D007288:Inosine; D003630:Daunorubicin
Proizvodnye daunorubitsina, soderzhashchie fragment inozina.