title: Noxious stimuli produce prolonged changes in the CA1 region of the rat hippocampus.
abstract: Limbic structures including the hippocampus are thought to be involved in pain though not much is known of their neuronal responses to noxious stimuli. In this report we show that a prolonged and substantial depression of the dorsal hippocampal CA1 pyramidal cell population spike is produced by a brief but intense noxious stimulus applied to the tail of lightly anaesthetized rats. This depression is temperature-dependent and habituates to subsequent noxious stimuli applied more than 1 h later. Further, the depression is absent when noxious heat is applied in the presence of hippocampal theta rhythm.
authors.affiliation: Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B.C. V6T 1 W5 Canada.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Khanna
authors.forename: John G
authors.initials: JG
authors.lastname: Sinclair
mesh_terms: D000200:Action Potentials; D000818:Animals; D006624:Hippocampus / Q000503:physiopathology*; D006358:Hot Temperature; D008297:Male; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains