title: [Efficacy of uvulopalatopharyngoplasty (UPPP) and modifications in sleep structure in the sleep apnea syndrome (SAS)].
abstract: Thirty-four patients (32 male, 2 female; mean age 53 +/- 7 years) with confirmed sleep apnea syndrome (SAS) were studied before and after uvulopalatopharyngoplasty (UPPP). Clinical symptoms were tiredness, excessive daytime sleepiness and snoring. All patients were overweight. Patients underwent a thorough physical and oropharyngeal examination and polysomnography before and 3 months after surgery. On the basis of post-operative results, patients are divided into 3 groups: --group 1: 16 cured patients: apnea index (A.I./h) 38 +/- 17 before and 4.4 +/- 4 apneas/h sleep after surgery. Improved nocturnal hypoxemia: mean minimum oxyhemoglobin saturation (SAO2) before and after UPPP in NREM sleep 83 +/- 4% v. 90 +/- 4% in REM sleep 76 +/- 11% v. 85 +/- 7%. Uninterrupted sleep is restored; --group 2: 8 improved patients: A.I./h of 64 +/- 11 before and 20 +/- 6 after UPPP: improved nocturnal hypoxemia: mean minimum SAO2 in NREM sleep 74 +/- 10% before and 86 +/- 6% after UPPP: in REM sleep 59 +/- 9% before and 79 +/- 6% after UPPP, lower amount and percentage of fragmented sleep; --group 3: 10 non-improved patients: A.I./h unchanged 55 +/- 22% before and 50 +/- 20% after UPPP. Persistent nocturnal hypoxemia: mean minimum SAO2 in NREM sleep 76 +/- 13 before and 81 +/- 12% after UPPP: in REM sleep 63 +/- 16% before and 65 +/- 24% after UPPP. Sleep remains fragmented. In this last group patients are more overweight and all suffer from severe SAS with greater nocturnal oxyhemoglobin desaturation. Surgical treatment by UPPP is shown to be effective for 70% of our patients. Better results are obtained when SAS is less severe and overweight less important.
authors.affiliation: Service d'explorations fonctionnelles-Neurologie, CHU Salpêtrière, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Laffont
authors.forename: B
authors.initials: B
authors.lastname: Lecendreux
authors.forename: M
authors.initials: M
authors.lastname: Minz
authors.forename: M O
authors.initials: MO
authors.lastname: Josse
authors.forename: P
authors.initials: P
authors.lastname: Waisbord
authors.forename: M
authors.initials: M
authors.lastname: Fleury
authors.forename: F
authors.initials: F
authors.lastname: Chabolle
authors.forename: H P
authors.initials: HP
authors.lastname: Cathala
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000503:physiopathology; D010160:Palate, Soft / Q000601:surgery*; D010614:Pharynx / Q000601:surgery*; D012891:Sleep Apnea Syndromes / Q000503:physiopathology / Q000601:surgery*; D012894:Sleep Stages / Q000502:physiology*; D014609:Uvula / Q000601:surgery*
vernacular_title: Efficacité de l'uvulopalatopharyngoplastie (UPPP) et modifications de la structure du sommeil dans le syndrome d'apnée du sommeil (SAS).