Restoration of dysgenic murine (mdg) myotube contraction after addition of Schwann cells from normal mice in vitro.
Muscular dysgenesis in mutant mice is characterised by failure of excitation-contraction (E-C) coupling and consequent loss of skeletal muscle contraction. Contractile activity is restored in vitro by the addition of normal mice cells (11) (18) (7). In the present study we show a new model: contraction and ultrastructural organization of dysgenic myotubes are restored by coculture with Schwann cells from normal mice.
Courbin
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Laboratoire de Neurobiologie cellulaire, Université de Bordeaux II, URA-CNRS #1126, Talence, France.
Do Thi
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Ressouches
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Dussartre
C
C
Powell
J A
JA
Koenig
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J
D000818:Animals; D002478:Cells, Cultured; D051379:Mice; D008817:Mice, Mutant Strains; D009119:Muscle Contraction; D009132:Muscles / Q000166:cytology* / Q000502:physiology; D012583:Schwann Cells / Q000166:cytology* / Q000502:physiology