[Antithrombotic effect of protein C activator from a snake venom].
Influence of the protein C activator from snake venom on blood coagulation was studied. Incubation of different concentrations of the activator with rat blood plasma resulted in a dose-dependent prolongation of the activated partial thromboplastin time (APTT). Cleavage of the protein C to the active form was detected by electrophoresis. Intravenous administration of the activator (100 mg/kg) into rats led to prolongation of APTT to 242 +/- 80%, to increase in the plasminogen activator level to 145 +/- 29% and to decrease in the factor V activity to 57 +/- 14%. When thrombosis was induced by means of administration of the thromboplastin lethal dose, pretreatment with the activator prevented animal death in 90% of cases. The effects of the activator observed appear to occur via transformation of the endogenous protein C into its active form.
Strukova
S M
SM
Kogan
A E
AE
Tara
A A
AA
Aaviksaar
A A
AA
D000818:Animals; D002417:Cattle; D004789:Enzyme Activation; D005343:Fibrinolytic Agents; D006487:Hemostasis / Q000187:drug effects*; D009842:Oligopeptides / Q000494:pharmacology*; D011486:Protein C / Q000378:metabolism*; D051381:Rats; D012910:Snake Venoms / Q000032:analysis*
D005343:Fibrinolytic Agents; D009842:Oligopeptides; D011486:Protein C; D012910:Snake Venoms; C047135:protein C activator peptide
Protivotromboticheskiĭ éffekt aktivatora proteina C iz zmeinogo iada.