The adenosine analogue and cerebral protecting agent, AMG-1, has no effect on delayed neuronal death following ischemia.
The chemical structure of AMG-1 was isolated during our search for an effective compound to overcome the untoward effects of complete ischemia. The duration of gasping was prolonged significantly and dose-dependently in mice by the administration of AMG-1, the efficacy being 1000 times that seen with adenosine. However, AMG-1 had no effect on ischemia-induced passive avoidance impairment and histopathological degradation in CAl neurons in the hippocampus. The relationship between adenosine and its analogue and cerebral ischemia is discussed.
Araki
H
H
Department of Pharmacology, Taisho Pharmaceutical Co., Saitama, Japan.
Karasawa
Y
Y
Kawashima
K
K
Hayashi
M
M
Aihara
H
H
Huang
J H
JH
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002545:Brain Ischemia / Q000473:pathology* / Q000503:physiopathology / Q000517:prevention & control; D002470:Cell Survival / Q000187:drug effects*; D005849:Gerbillinae; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects
C063248:6-(5-hydroxy-2-pyridylmethylamino)-9-beta-ribofuranosylpurine; D010424:Pentobarbital; D000241:Adenosine