title: [Differentiation of hepatic sinusoid vessel cells in rats in the embryonal and postnatal periods of ontogenesis].
abstract: Differentiation of the hepatic sinusoidal capillary cells has been studied in the embryonal and postnatal periods of the rat ontogenesis. In the embryonal liver cellular elements are differentiated divergently with formation of endotheliocytes, Kupffer cells and fat-accumulating cells. Differentiation of endotheliocytes is accompanied with their flattening, formation of fenestrae and pores in peripheral processes, increasing amount of micro- and macropinocytic vesicles, and also development of intercellular contacts, presented at first as simple, and then as tight junctions. Formation of intercellular clefts occurs by means of parting of simple junctions; this ensures migration of blood cells across the endothelial lining. Kupffer cells develop out of immature macrophagal elements of the perisinusoidal space. During differentiation they migrate into the endothelial lining. Simultaneously in their cytoplasm lysosomes accumulate and acid phosphatase activity increases. The fat-accumulating cells are formed out of poorly differentiating fibroblast-like elements of the perisinusoidal space. Their differentiation is accompanied with a progressive development of the granular endoplasmic reticulum and with accumulation of reticular fibers in the perisinusoidal space, and in cytoplasm--lipid inclusions.
authors.forename: E K
authors.initials: EK
authors.lastname: Vishnevskaia
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000033:anatomy & histology*; D002454:Cell Differentiation; D004622:Embryo, Mammalian / Q000166:cytology*; D004727:Endothelium / Q000166:cytology / Q000648:ultrastructure; D005347:Fibroblasts / Q000166:cytology / Q000648:ultrastructure; D005865:Gestational Age; D007728:Kupffer Cells / Q000166:cytology / Q000648:ultrastructure; D008099:Liver / Q000166:cytology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D051381:Rats
vernacular_title: Differentsirovka kletok sinusoidnykh sosudov pecheni v émbrio- na'lnom postnata'lnom periodakh ontogeneza krysy.