title: In vitro immunoglobulin production in mitogen-stimulated cultures of peripheral blood and bone marrow cells from young and old adults, and cases of benign monoclonal gammopathy.
abstract: Peripheral blood samples collected from normal individuals and patients with benign monoclonal gammopathy (BMG) were separated and assayed for their T-cell subpopulations, PHA blast formation as well as immunoglobulin (Ig) synthesis in vitro. Bone marrow cells of most the cases were also assayed for Ig synthesis. Age-related changes of T-cell subsets and PHA blast formation revealed a marked leveling off after the 8th decade. Comparing the age-related increase in Ig synthesis in peripheral blood lymphocytes, PWM-induced Ig synthesis of bone marrow cells was only slightly increased. The distribution of values for T-cell subsets, PHA blast formation and Ig synthesis in the BMG cases more closely resembled that in the aged than that in the age-matched controls. Immunoregulatory functions seem to be affected in BMG.
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Hosoi
authors.forename: A
authors.initials: A
authors.lastname: Urabe
authors.forename: F
authors.initials: F
authors.lastname: Takaku
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000276:immunology*; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology*; D002478:Cells, Cultured; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007136:Immunoglobulins / Q000096:biosynthesis*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology*; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000276:immunology*
chemical_list: D007136:Immunoglobulins; D008934:Mitogens