[Telomeric fusion of the chromosomes in cells with micronuclei during the subsequent incorporation into the DNA of thymidine halogenated analogs].
As was shown elsewhere among halogenated analogs of thymidine there exist strong (5-chlorodeoxyuridine, 5-ChldU) and weak (5-iododeoxyuridine, 5-IdU) inducers of dicentric chromosomes in cells with micronuclei. Since from colcemid administration to the moment of fixation two cycles of replication are passed, a study was made of the pattern of induction of dicentric chromosomes under subsequent administration of 5-ChldU and 5-IdU, and the other way round. It was shown that the pattern of induction of dicentric chromosomes was strong or weak, and depended on the fact which analog was administered in the first S-period.
Stobetskiĭ
V I
VI
Mironova
L L
LL
D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D002875:Chromosomes / Q000187:drug effects* / Q000378:metabolism; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects*; D003703:Demecolcine / Q000494:pharmacology; D003857:Deoxyuridine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D007065:Idoxuridine / Q000378:metabolism / Q000494:pharmacology; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects* / Q000378:metabolism; D013936:Thymidine / Q000031:analogs & derivatives* / Q000378:metabolism
C012244:5-chloro-2'-deoxyuridine; D004247:DNA; D007065:Idoxuridine; D013936:Thymidine; D003857:Deoxyuridine; D003703:Demecolcine
Telomernoe sliianie khromosom v kletkakh s mikroiadrami pri posledovatel'nom vkliuchenii v DNK galogenovykh analogov timidina.