[Effects of mellitic acid on matrix-induced, ectopic osteogenesis in the rat].
Similar to diphosphonates mellitic acid is characterized by its high affinity to Calcium-phosphate-minerals. Mellitic acid inhibits the crystallization of hydroxyapatite in vitro and in vivo. Local application of mellitic acid (concentration 1 mmol/l) proved not to impair osteoinduction and development of nature bone in the matrixinduced ectopic osteogenesis. But in the course of osteogenesis prominent masses of cartilage developed. Higher local concentrations of mellitic acid may be efficient in the therapy of ectopic ossification, but also may be accompanied by formation of crystal deposition.
Rüther
W
W
Orthopädische Klinik, Universität Bonn.
Kindermann
D
D
Gorissen
S
S
Gebhardt
M
M
Münzenberg
K J
KJ
D000818:Animals; D001514:Bee Venoms / Q000494:pharmacology*; D015519:Bone Density / Q000187:drug effects*; D001857:Bone Matrix / Q000637:transplantation*; D002356:Cartilage / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects*; D008297:Male; D008555:Melitten / Q000494:pharmacology*; D010006:Osteoblasts / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D001514:Bee Venoms; D008555:Melitten
Wirkungen der Mellitsäure auf die matrixinduzierte, ektope Osteoneogenese bei der Ratte.