Administration of activated charcoal or sodium polystyrene sulfonate (Kayexalate) as gastric decontamination for lithium intoxication: an animal model.
To determine whether sodium polystyrene sulfonate (SPS; Kayexalate) is effective in decreasing the absorption of lithium (Li) and to test the assumption that Li is poorly adsorbed by activated charcoal, 130 mice were administered an orogastric dose of LiCl (250 mg/kg) followed immediately by orogastric SPS (10 g/kg, SPS Group), activated charcoal (6.7 g/kg, AC Group), or water in an equivalent volume (Control Group). Subgroups of each of the 3 groups were sacrificed at 1, 2, 4 and 8 hr after treatment and serum analyzed for Li concentration. Statistical analyses revealed no overall difference between the AC Group and the Control Group. However, the SPS Group differed from both the Control and the AC Group at each time interval, with Li concentrations significantly lower in the SPS Group. These results demonstrate that: 1) SPS, in this study, effectively reduced serum Li concentrations in an in vivo model, and 2) activated charcoal did not.
Linakis
J G
JG
Programme in Clinical Pharmacology/Toxicology, Harvard Medical School, Boston, MA.
Lacouture
P G
PG
Eisenberg
M S
MS
Maher
T J
TJ
Lewander
W J
WJ
Driscoll
J L
JL
Woolf
A D
AD
D000818:Animals; D002606:Charcoal / Q000627:therapeutic use*; D007408:Intestinal Absorption; D008094:Lithium / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D008297:Male; D051379:Mice; D011137:Polystyrenes / Q000627:therapeutic use*
D011137:Polystyrenes; D002606:Charcoal; C003321:polystyrene sulfonic acid; D008094:Lithium