title: A cytotoxic constituent of Lysimachia japonica THUNB. (Primulaceae) and the structure-activity relationships of related compounds.
abstract: A cytotoxic alkylresorcinol was isolated from Lysimachia japonica THUNB. (Primulaceae) and identified as grevillol (2). It was tested for cytotoxicity against KB, B-16, PC-13, L-5178Y, P-388, and HEp-2 cells in vitro. Synthetic related compounds were also tested for cytotoxicity against the KB cell line, and the structure-activity relationships are discussed.
authors.forename: M
authors.initials: M
authors.lastname: Arisawa
authors.forename: K
authors.initials: K
authors.lastname: Ohmura
authors.forename: A
authors.initials: A
authors.lastname: Kobayashi
authors.forename: N
authors.initials: N
authors.lastname: Morita
mesh_terms: D002470:Cell Survival / Q000187:drug effects*; D006801:Humans; D007624:KB Cells; D010946:Plants, Medicinal / Q000032:analysis*; D013329:Structure-Activity Relationship