Protein kinase C deficiency in juvenile chronic myeloid leukemia: a case report.
Protein kinase C activity was assayed in morphologically differentiated and undifferentiated myeloid cells of a 13-month-old girl with chronic myeloid leukemia. A reduced protein kinase C activity was seen in the morphologically differentiated neutrophils, while the activity in the leukemic cells was higher to that of normal neutrophils from control subjects.
Courtois
P
P
Faculty of Medicine, Department of Pediatrics, Free University of Brussels, Belgium.
Ferster
A
A
Fondu
P
P
Mandelbaum
I M
IM
D000328:Adult; D002454:Cell Differentiation / Q000187:drug effects; D002648:Child; D005260:Female; D006801:Humans; D007223:Infant; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000201:enzymology* / Q000473:pathology; D009363:Neoplasm Proteins / Q000032:analysis; D009504:Neutrophils / Q000201:enzymology*; D011493:Protein Kinase C / Q000172:deficiency*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D009363:Neoplasm Proteins; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate