Inhibition of acetylcholinesterase by diastereomers of 2-methylamino-1-phenylpropanol and their derivatives.
The anti-acetylcholinesterase activities of the ephedrine diastereomers and their N-methyl derivatives were correlated to the conformation of the molecules in solution. The stereospecificity exhibited by enantiomers of N-methyl-psi-ephedrine was attributed to the predominance of one preferred conformation. The possibility of predicting the absolute configuration of chiral inhibitors from enzyme inhibitions data is discussed.
Ngiam
T L
TL
Go
M L
ML
D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004809:Ephedrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D004809:Ephedrine