Low-density lipoprotein amplifies the platelet response to serotonin in human plasma.
The effect of low-density lipoprotein, serotonin and low-density lipoprotein plus serotonin on platelet aggregation (measured ex vivo in plasma) was studied in 28 normotensive subjects (15 non-smokers, 13 smokers) and 15 previously untreated non-smoking patients with essential hypertension. Low-density lipoprotein alone had no platelet-activating effect. Serotonin-induced platelet aggregation was enhanced by low-density lipoprotein in both the normotensive and the hypertensive subjects. The platelet response to low-density lipoprotein plus serotonin was higher in the smokers than in the non-smokers; it was also higher in the hypertensive patients than in the normotensive controls. We conclude that low-density lipoprotein activates platelets in plasma via an interaction with a serotonergic mechanism. Low-density lipoprotein amplifies the serotonin-induced platelet aggregation (normally reversible), making it irreversible. A higher platelet response to low-density lipoprotein plus serotonin in patients with essential hypertension may be of pathophysiological relevance in respect to the thrombovascular lesions accompanying hypertension and/or atherosclerosis.
Fetkovska
N
N
Clinic of Pharmacotherapy, Medical Bionics Research Institute, Bratislava, Czechoslovakia.
Fedelesova
V
V
Dzurik
R
R
D000328:Adult; D000368:Aged; D004347:Drug Interactions; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000187:drug effects* / Q000502:physiology; D015539:Platelet Activation / Q000187:drug effects / Q000502:physiology; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology*; D012907:Smoking / Q000097:blood
D008077:Lipoproteins, LDL; D012701:Serotonin