Neurophysiological and behavioural effects of combined exposure to 2,5-hexanedione and acetone or ethanol in rats.
Rats were dosed with 2,5-hexanedione (2,5-HD), acetone, ethanol or combinations of these for 6 weeks. Nerve conduction velocity (NCV) was measured in the tails of the rats once a week from the third week of dosing. Behaviour was monitored during the whole experiment as performance on a rotarod, in 30 sec. sessions. 2,5-HD alone showed a significant effect on NCV and rotarod performance after 3 weeks of dosing. Acetone, but not ethanol, together with 2,5-HD had an additional significant effect on NCV and rotarod performance of the rats. This additional effect was seen from the 4th dosage week. The mechanism behind this effect is partly unknown.
Ladefoged
O
O
Department of Toxicology and Biology, Danish National Institute of Occupational Health, Copenhagen.
Hass
U
U
Simonsen
L
L
D000096:Acetone / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity*; D006588:Hexanones / Q000633:toxicity*; D007659:Ketones / Q000633:toxicity*; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D006588:Hexanones; D007659:Ketones; D000096:Acetone; D000431:Ethanol; C011269:2,5-hexanedione