[Present status and background of occupational uroepithelial tumors].
The incidence of urothelial cancers in a group of 231 dyestuff plant workers who had been exposed to benzidine (BZ) or to beta-naphthylamine (BNA) was surveyed from 1962 to 1988. Fifteen out of 231 patients (6.5%) were found to have bladder cancer with the mean age at onset of 57.1 +/- 8.7 years. The estimated average period of engaging in this dyestuff exposure for these 15 patients was 92.4 +/- 47.3 months. The mean latent periods from the initial and last exposure until tumor development were 28.8 +/- 5.7 years and 16.6 +/- 7.0 years, respectively. Good negative correlation was observed between exposure periods and latent periods from the last exposure to onset (R = -0.06814). All 15 patients demonstrated tumors in the bladder, and one patient had a metachronous upper urinary tract cancer after treatment for bladder cancer. All tumors were histologically transitional cell carcinomas except for one adenocarcinoma. For initial treatment, five underwent total cystectomy, eight had transurethral resection (TUR) of the tumor, and one had partial cystectomy. Five out of 8 patients who had TUR have developed recurrent bladder tumors, and two of those patients underwent total cystectomy for second treatments. The mean follow-up period was 8.6 +/- 5.2 years, with two dying of cancer. For detection and monitoring, flow cytometric (FCM) analyses were available in five cases with bladder tumor and in two follow-up cases after bladder preserving treatments.(ABSTRACT TRUNCATED AT 250 WORDS)
Tachibana
M
M
Department of Urology, School of Medicine, Keio University.
Tazaki
H
H
Murai
M
M
Yamaguch
N
N
D015081:2-Naphthylamine / Q000009:adverse effects*; D001560:Benzidines / Q000009:adverse effects*; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced* / Q000453:epidemiology; D005434:Flow Cytometry; D006801:Humans; D007564:Japan / Q000453:epidemiology; D009281:Naphthalenes / Q000009:adverse effects*; D009784:Occupational Diseases / Q000139:chemically induced* / Q000453:epidemiology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D014556:Urine / Q000166:cytology
D001560:Benzidines; D009281:Naphthalenes; C029876:benzidine; D015081:2-Naphthylamine