title: [Optical and electron microscopic study of the kidney of dogs naturally and experimentally infected with Leishmania (Leishmania) chagasi].
abstract: Two naturally infected dogs (male and female) from Teófilo Otoni (MG-Brazil) were maintained for 18 months in our laboratory. Two other dogs, two months old males were infected with 1 x 10(6) promastigotes of MHO/BR/70/BH46 Leishmania (Leishmania) chagasi strain, endovenous route, and autopsied after 10 months and two years. The main findings concerning the kidney were: (1) focal or diffuse mesangial glomerulonephritis with proliferative and enlargement of mesangial cells; (2) increase in thickness of basement membrane with electron-dense deposits; (3) chronic interstitial nephritis with intense exudation of plasmocytes; (4) cloud swelling of renal tubules. The authors discuss the probable pathogenetic mechanisms.
authors.forename: W L
authors.initials: WL
authors.lastname: Tafuri
authors.forename: M S
authors.initials: MS
authors.lastname: Michalick
authors.forename: M
authors.initials: M
authors.lastname: Dias
authors.forename: O
authors.initials: O
authors.lastname: Genaro
authors.forename: V H
authors.initials: VH
authors.lastname: Leite
authors.forename: A J
authors.initials: AJ
authors.lastname: Barbosa
authors.forename: E A
authors.initials: EA
authors.lastname: Bambirra
authors.forename: C A
authors.initials: CA
authors.lastname: da Costa
authors.forename: M N
authors.initials: MN
authors.lastname: Melo
authors.forename: W
authors.initials: W
authors.lastname: Mayrink
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology*; D007668:Kidney / Q000473:pathology / Q000648:ultrastructure*; D007898:Leishmaniasis, Visceral / Q000150:complications*; D008297:Male; D009395:Nephritis, Interstitial / Q000209:etiology*
vernacular_title: Estudo, ao microscópio óptico e eletrônico, do rim de cães natural e experimentalmente infectados com Leishmania (Leishmania) chagasi.