Biodistribution of 131I-radiolabelled plasma low density lipoprotein in hyperlipidaemic vervet monkeys.
Low density lipoprotein (LDL) labelled with 131I has been administered to 6 Vervets 2 of which were high responders to an atherogenic Western diet in terms of plasma cholesterol, 2 were low responders and 2 were fed a high carbohydrate control diet. The ratio of hepatic to cardiac activity was recorded for up to 10 days after administration of the labelled LDL. Liver activity had a longer biological half life in the high-responders and this can be interpreted in terms of a variation of hepatic metabolism of LDL, with direct relevance to the human situation.
Wynchank
S
S
Research Institute for Medical Biophysics, Medical Research Council, Tygerberg, South Africa.
Fincham
J E
JE
Klopper
J F
JF
Wasserman
H J
HJ
Weight
M J
MJ
D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism*; D002521:Cercopithecus; D004036:Diet, Atherogenic; D005260:Female; D006207:Half-Life; D006937:Hypercholesterolemia / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008077:Lipoproteins, LDL / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D008077:Lipoproteins, LDL