Comparison of the cardiorespiratory effects of ketorolac and alfentanil during propofol anaesthesia.
The cardiorespiratory effects of a new nonopioid analgesic, ketorolac tromethamine, were compared with alfentanil as part of a balanced technique in which anaesthesia was maintained by a constant infusion of propofol. Twenty patients were allocated randomly to receive a single dose of either ketorolac 30 mg or alfentanil 0.5 mg. The study medication was given during the anaesthetic when the rate of ventilation had been stable (+/- 1 b.p.m.) for 5 min. Measurements of ventilatory rate, end-tidal carbon dioxide partial pressure, arterial oxygen saturation (SaO2), heart rate and systemic arterial pressure were made at 1-min intervals for 15 min following the test drug. Patients having alfentanil developed significant decreases in ventilatory rate, heart rate and mean arterial pressure. A significant increase in end-tidal carbon dioxide partial pressure occurred also. No changes occurred in any of the measured variables in the ketorolac group.
Murray
A W
AW
University Department of Anaesthesia, Royal Infirmary, Glasgow.
Brockway
M S
MS
Kenny
G N
GN
D015760:Alfentanil / Q000494:pharmacology*; D000771:Anesthesia, Intravenous; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D020911:Ketorolac Tromethamine; D008297:Male; D008875:Middle Aged; D015742:Propofol; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors; D014046:Tolmetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014325:Tromethamine / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D014325:Tromethamine; D015760:Alfentanil; D020911:Ketorolac Tromethamine; D014046:Tolmetin; D015742:Propofol