Neurofollicular hamartoma: a light microscopic and immunohistochemical study.
Neurofollicular hamartoma is an unusual, previously undescribed neoplasm characterized by a proliferation of spindle cells and hyperplastic pilosebaceous units. Five cases were reviewed. The lesions presented as single, asymptomatic, smooth, flesh-colored papules. Four were on the nose, and one on the adjacent nasolabial fold. Immunoperoxidase studies performed on two cases utilizing antibodies to S-100 antigen were positive in both. These lesions share some histological and clinical features with angiofibroma and neurofibroma.
Barr
R J
RJ
Department of Dermatology, University of California, Irvine.
Goodman
M M
MM
D000328:Adult; D000368:Aged; D005153:Facial Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006222:Hamartoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000378:metabolism / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
D009418:S100 Proteins