Probabilistic division systems modeling the generation of mosaic fields.
The explanation of mosaic pattern in chimeric organs analyzed by in situ methods requires modeling of specific hypotheses. The use of computer simulations to achieve this has led to the conclusion that finely variegated mixtures of cell lineage within chimeric tissues does not require extensive cell movement. Cell division models were used to determine the distribution of patch size as mosaic fields are generated. The results establish that these distributions are sensitive to the proportion of the two cell types which comprise the mosaic.
Iannaccone
P M
PM
Department of Pathology, Northwestern University, Chicago, IL 60611.
Berkwits
L
L
Joglar
J
J
Lindsay
J
J
Lunde
A
A
D000818:Animals; D002455:Cell Division / Q000502:physiology; D002678:Chimera / Q000502:physiology*; D003198:Computer Simulation; D008954:Models, Biological; D011336:Probability