Oligoribonucleotide synthesis by use of the 2-(methylthio)-phenylthiomethyl (MPTM) group.
The 2-(methylthio)phenylthiomethyl (MPTM) group was developed as a new type of 2'-hydroxyl protecting group in oligoribonucleotide synthesis. The building monomer units of uridine and cytidine for the phosphotriester approach were synthesized from 2'-O-(1,3-benzodithiol-2-yl)-3',5'-O- (1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)uridine and successfully utilized for the synthesis of CpUpG.
Sekine
M
M
Department of Environmental Chemistry and Engineering, Tokyo Institute of Technology, Yokohama, Japan.
Nakanishi
T
T
D007202:Indicators and Reagents; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D012833:Siloxanes; D014220:Trialkyltin Compounds; D014529:Uridine / Q000031:analogs & derivatives
D007202:Indicators and Reagents; D009843:Oligoribonucleotides; D012833:Siloxanes; D014220:Trialkyltin Compounds; C011559:tributyltin; C062346:2'-O-(1,3-benzodithiol-2-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)uridine; D014529:Uridine