[Shifts in the parameters of cardio- and hemodynamics and their correction using liposomes in the process of the development of septic shock].
The interdependence between changes in central cardiac hemodynamics and regional blood flow has been studied in dogs with experimental septic shock. Possible correction of the above damages by direct delivery of liposomes to tissues of the septic focus has been investigated. It has been found that vascular insufficiency is primary in the genesis of decompensated circulatory disturbances, with its progress leading to the inhibition of pump and contractility cardiac functions. Regional subcutaneous administration of liposomes in developing septic shock prevents the onset of cardiovascular disturbances.
Khromov
A S
AS
Sagach
V F
VF
Dmitrieva
A V
AV
Doloman
L B
LB
Kreĭnes
V M
VM
D000818:Animals; D004285:Dogs; D005260:Female; D006439:Hemodynamics; D007279:Injections, Subcutaneous; D008081:Liposomes / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D012772:Shock, Septic / Q000503:physiopathology* / Q000628:therapy
D008081:Liposomes
Sdvigi parametrov kardio- i gemodinamiki i ikh korrektsiia s pomoshch'iu liposom v protsesse razvitiia septicheskogo shoka.