[The effect of almagel on euphylline absorption in children with bronchial asthma].
The study of almagel effect on euphylline absorption in children with bronchial asthma showed a decrease of theophylline concentration by 10-15% ten days after the combined administration of the drugs. The absence of the change in the blood theophylline concentration three days after administration of almagel against the background of euphylline indicates that the reason for a decrease of euphylline absorption is not the absorbing and lubricating properties of almagel but probably almagel-induced reduction of the inflammation of the gastrointestinal tract mucosa (hyperemia, increased vascular permeability) caused by euphylline.
Smirnov
D P
DP
Zabolipenskaia
E P
EP
D000042:Absorption; D000293:Adolescent; D000536:Aluminum Hydroxide / Q000627:therapeutic use*; D000628:Aminophylline / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D001566:Benzocaine / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use*; D008276:Magnesium Hydroxide / Q000627:therapeutic use*; D013806:Theophylline / Q000097:blood; D013997:Time Factors
D004338:Drug Combinations; C010016:aluminum hydroxide, benzocaine, magnesium hydroxide drug combination; D000628:Aminophylline; D000536:Aluminum Hydroxide; D013806:Theophylline; D008274:Magnesium; D008276:Magnesium Hydroxide; D001566:Benzocaine
Vliianie almagelia na vsasyvanie éufillina u deteĭ s bronkhial'noĭ astmoĭ.