title: [Clinical assessment of the role of circadian rhythm of hormone contents in the blood and saliva of children with congenital dysfunction of the adrenal cortex].
abstract: It has been shown that data on circadian rhythms of 17-hydroxyprogesterone and testosterone content in children with congenital dysfunction of the adrenal cortex before and during treatment can be used in the control of treatment adequacy. Regular adequate intake of prednisolone brings about a decrease in hormonal content both in the blood and the saliva. Serial collection of salivary samples from children over 3 years of age is feasible and painless as compared to venous puncture, causing no adverse response on the child's part.
authors.forename: O V
authors.initials: OV
authors.lastname: Fofanova
mesh_terms: D019326:17-alpha-Hydroxyprogesterone; D000312:Adrenal Hyperplasia, Congenital / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000032:analysis* / Q000097:blood; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012463:Saliva / Q000032:analysis*; D013739:Testosterone / Q000032:analysis* / Q000097:blood
chemical_list: D006908:Hydroxyprogesterones; D013739:Testosterone; D019326:17-alpha-Hydroxyprogesterone; D011239:Prednisolone
vernacular_title: Klinicheskaia otsenka roli sutochnykh ritmov soderzhaniia gormonov v krovi i sliune u deteĭ s vrozhdennoĭ disfunktsieĭ kory nadpochechnikov.