[Effect of glycosides of betulafolientriol and its 3-epimer on the growth of tumor cells in vitro].
The effect of triterpene glycosides synthesized on the basis of betulafolientriol, ginsenoside Rb1 from gingseng, betulafolientriol and its 3-epimer on the growth of the Ehrlich tumor cell cultures was studied. It was shown that, in relation to the quantitative composition and sites of carbohydrate residue linkage to aglycone as well as configuration of the alpha- or beta-hydroxyl group at C-3, the activity of the triterpenoids of the dammaranic series changed within wide ranges. 3- and 12-0-beta-D-glycosides of 3-epibetulafolientriol proved to be the most active.
Shentsova
E B
EB
Anisimov
M M
MM
Loenko
Iu N
IuN
Atopkina
L N
LN
Samoshina
N F
NF
Uvarova
N I
NI
D000818:Animals; D000970:Antineoplastic Agents; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D003470:Culture Media; D006027:Glycosides / Q000494:pharmacology*; D066298:In Vitro Techniques; D010936:Plant Extracts / Q000494:pharmacology*; D014197:Trees; D014315:Triterpenes / Q000494:pharmacology*; D000094062:Betulinic Acid
D000970:Antineoplastic Agents; D003470:Culture Media; D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes; C063428:betulafolientriol; D000094062:Betulinic Acid
Vliianie glikozidov betulafolientriolai ego 3-épimera na rost opukholevykh kletok in vitro.