In-vitro activity of DR-3355, an optically active isomer of ofloxacin, against bacterial pathogens associated with travellers' diarrhoea.
The in-vitro activity of DR-3355, the S-(-)-isomer of ofloxacin, was determined against bacterial pathogens associated with travellers' diarrhoea. DR-3355 was highly active against isolates of enteropathogenic Escherichia coli (MIC90 0.05 mg/l), Salmonella spp. (MIC90 0.10 mg/l), Shigella spp. (MIC90 0.10 mg/l), Campylobacter jejuni (MIC90 0.39 mg/l) and Vibrio parahaemolyticus (MIC90 0.39 mg/l). The activity of DR-3355 against these bacteria was generally two- to eight-fold greater than that of ofloxacin and equal to, or only two-fold less than, that of ciprofloxacin with the exception of isolates of C. jejuni, which were two-fold less susceptible to ciprofloxacin than to DR-3355.
Inagaki
Y
Y
Department of Microbiology, School of Medicine, Tokyo Medical and Dental University, Japan.
Horiuchi
S
S
Une
T
T
Nakaya
R
R
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002939:Ciprofloxacin / Q000494:pharmacology; D003967:Diarrhea / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000031:analogs & derivatives / Q000494:pharmacology*; D013237:Stereoisomerism; D014195:Travel
D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D015242:Ofloxacin