title: Risk factor interactions for coronary heart disease.
abstract: There is now an increasing awareness of the atherogenicity of the individual lipoprotein subfractions. In addition, the effects of commonly used antihypertensive drugs has been a cause for concern. Thiazides and loop diuretics both increase LDL cholesterol, but indapamide and spironolactone have no apparent effects. Beta-blocker monotherapy may also increase triglycerides whilst post-synaptic alpha-blockers do not affect, or slightly lower triglycerides, total cholesterol, LDL and VLDL levels.
authors.affiliation: Institute of Protein Research, University of Berne, Switzerland.
authors.forename: R C
authors.initials: RC
authors.lastname: Mordasini
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects; D001053:Apolipoproteins / Q000502:physiology; D003327:Coronary Disease / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D008074:Lipoproteins / Q000502:physiology; D008075:Lipoproteins, HDL / Q000502:physiology; D011973:Receptors, LDL / Q000378:metabolism; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents; D001053:Apolipoproteins; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D011973:Receptors, LDL