[The effect of hyperbaric oxygenation, alpha-tocopherol and their combination on lipoprotein lipid metabolism in the blood plasma of rabbits with hypercholesterolemia].
Hyperbaric oxygenation (HBO) led to acceleration of free-radical oxidation of blood plasma lipids, reduction of the fraction of linoleic acid residues in phospholipids, and inhibition of the fractional rate of the lecithin-cholesterol-acyl-transferase reaction in rabbits with severe hypercholesterolemia. In group 2 of rabbits with similar hypercholesterolemia administration of alpha-tocopherol increased the content of high density lipoprotein phospholipids, the activity of hepatic endothelial lipase and the cholesterol esterifying activity of blood plasma, and accelerated hypercholesterolemia regression. Combination of HBO and alpha-tocopherol in group 3 of rabbits with hyper-cholesterolemia decelerated the accumulation of the products of free-radical oxidation in blood plasma; the activity of the lecithin-cholesterol-acyltransferase reaction increased in this case, while the regression of hypercholesterolemia was accelerated. It is concluded that some unfavourable changes of lipid metabolism occurring under the effect of HBO in hypercholesterolemia can be corrected with alpha-tocopherol.
Kosukhin
A B
AB
D000818:Animals; D001059:Apoproteins / Q000097:blood; D003131:Combined Modality Therapy; D006931:Hyperbaric Oxygenation; D006937:Hypercholesterolemia / Q000097:blood / Q000628:therapy*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D011817:Rabbits; D012074:Remission Induction; D012075:Remission, Spontaneous; D014810:Vitamin E / Q000627:therapeutic use*
D001059:Apoproteins; D008055:Lipids; D008074:Lipoproteins; D014810:Vitamin E
Vliianie giperbaricheskoĭ oksigenatsii, al'fa-tokoferola i ikh kombinatsii na metabolizm lipidov lipoproteidov v plazme krovi u krolikov s giperkholesterinemieĭ.