title: [The role of long-chain acyl-CoA in the disturbances of oxidative phosphorylation in the myocardium].
abstract: The effect of intramitochondrial acyl-CoA on the respiration of rabbit heart mitochondria in different metabolic states was studied. Acyl-CoA inhibited O2 consumption by 11% in State 4 and by 6% in State 3. However, the effect of acyl-CoA was more pronounced (20%) in the intermediate state of respiration between State 4 and State 3. The data obtained suggest that acyl-CoA can regulate oxidative phosphorylation in heart mitochondria in vivo.
authors.forename: V I
authors.initials: VI
authors.lastname: Borutaĭte
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Mildazhene
authors.forename: L I
authors.initials: LI
authors.lastname: Ivanovene
authors.forename: B N
authors.initials: BN
authors.lastname: Kholodenko
authors.forename: A I
authors.initials: AI
authors.lastname: Toleĭkis
authors.forename: A K
authors.initials: AK
authors.lastname: Prashkiavichius
mesh_terms: D000214:Acyl Coenzyme A / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D007700:Kinetics; D008929:Mitochondria, Heart / Q000201:enzymology / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D011817:Rabbits
chemical_list: D000214:Acyl Coenzyme A; D000244:Adenosine Diphosphate; D003402:Creatine Kinase
vernacular_title: Rol' dlinnotsepochechnykh atsil-KoA v narushenii okislitel'nogo fosforilirovaniia v miokarde.