Effects of intraocular dapiprazole in the rabbit eye.
Dapiprazole produces miosis by blocking the alpha 1 receptors in the radial muscle of the iris; its intraocular effect has not yet been investigated. In this preliminary experimental animal study, we investigated the intracameral use of 0.2 ml of 0.005%, 0.0075%, 0.01%, and 0.05% dapiprazole to reverse mydriasis by 10% phenylephrine plus 0.5% tropicamide. With the 0.05% dapiprazole concentration, the values (mean +/- S.E.) of pupillary diameter were as follows: prior to the experiment, 5.3 +/- 0.31 mm; after mydriatics, 8.7 +/- 0.22 mm; after intraocular dapiprazole, 5.6 mm +/- 0.29. The results showed a dose-related miotic effect of dapiprazole. No difference in the toxicity parameters (inflammatory score, corneal thickness, endothelial cell counting, aqueous humor protein concentration, and intraocular pressure) was found between dapiprazole-treated eyes and saline-solution-treated eyes. Intraocular 0.01% and 0.05% dapiprazole is an effective miotic agent that may be helpful during surgery when the reversal of sympathomimetic mydriasis is needed.
Bonomi
L
L
Institute of Ophthalmology, University of Verona, Italy.
Marchini
G
G
Pagello
P
P
Simonazzi
A
A
Durando
L
L
Ciarniello
M G
MG
D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects; D001082:Aqueous Humor / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004728:Endothelium, Corneal / Q000187:drug effects / Q000378:metabolism; D005260:Female; D008297:Male; D010656:Phenylephrine / Q000037:antagonists & inhibitors; D010879:Piperazines; D011680:Pupil / Q000187:drug effects*; D011817:Rabbits; D014230:Triazoles / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D014331:Tropicamide / Q000037:antagonists & inhibitors
D010879:Piperazines; D014230:Triazoles; D010656:Phenylephrine; C035289:dapiprazole; D014331:Tropicamide