title: Blunted glucose-induced thermogenesis in 'overweight' patients: a factor contributing to relapse of obesity.
abstract: Glucose-induced thermogenesis was studied in 12 overweight patients (9F and 3M) before (mean body weight +/- s.e.m. 83 +/- 2 kg) and after weight loss (68 +/- 2 kg), and in eight of the same patients following relapse of body weight gain (84 +/- 5 kg). Expressed as a percentage of the energy content of the 100 g oral glucose load, glucose-induced thermogenesis was lower in the overweight before weight loss (6.5 +/- 0.5 per cent, P less than 0.05), after weight loss (3.9 +/- 0.6 per cent, P less than 0.01) and after weight regain (6.3 +/- 0.9 per cent, P less than 0.05) than in a group of lean control subjects, matched for sex and age (8.3 +/- 0.5 per cent). Basal energy expenditure was lower after weight reduction than before (1.16 +/- 0.04 vs 1.41 +/- 0.08 kcal/min, P less than 0.01). In the formerly overweight patients, the combined effect of a decreased basal energy expenditure and an attenuation of glucose induced thermogenesis resulted in a postprandial energy expenditure which was markedly lower than in the overweight state (P less than 0.001). Following relapse of obesity, glucose-induced thermogenesis remained attenuated compared to control subjects. These results suggest that a lowered basal energy expenditure and a reduced glucose-induced thermogenesis contribute to the positive energy balance which results in relapse of body weight gain after cessation of a hypocaloric diet.
authors.affiliation: Department of Internal Medicine, CHUV, Lausanne, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Golay
authors.forename: Y
authors.initials: Y
authors.lastname: Schutz
authors.forename: J P
authors.initials: JP
authors.lastname: Felber
authors.forename: D
authors.initials: D
authors.lastname: Jallut
authors.forename: E
authors.initials: E
authors.lastname: Jéquier
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000378:metabolism*; D012008:Recurrence; D015431:Weight Loss / Q000502:physiology*
chemical_list: D001786:Blood Glucose