Glutathione monoesters.
Glutathione monoesters in which the glycine carboxyl group is esterified are effective cellular glutathione delivery agents because they are readily transported into cells and are deesterified intracellularly. In contrast, glutathione itself is not effectively transported into cells. Detailed procedures are given for the preparation of such esters from glutathione and the corresponding alcohol using hydrogen chloride or sulfuric acid as the catalyst.
Anderson
M E
ME
Department of Biochemistry, Cornell University Medical College, New York, New York 10021.
Meister
A
A
D002264:Carboxylic Acids / Q000138:chemical synthesis*; D002625:Chemistry, Organic / Q000379:methods; D004952:Esters / Q000138:chemical synthesis*; D005978:Glutathione / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D006851:Hydrochloric Acid; D013464:Sulfuric Acids
D002264:Carboxylic Acids; D004952:Esters; D013464:Sulfuric Acids; C042431:S-ethyl glutathione; D005978:Glutathione; C033158:sulfuric acid; D006851:Hydrochloric Acid