title: Effect of prostaglandin E2 and indomethacin on blood flow in the lower urinary tract of the rabbit.
abstract: The effect of the cyclooxygenase system on lower urinary tract blood flow was investigated in a standardized rabbit model with empty bladder. Twenty-eight New-Zealand white rabbits were separated into 3 groups. The first group received 1 mg per kg b.w. s.c. daily of PGE2 for 4 days. The second group received 10 mg per kg of indomethacin perorally daily for 7 days. The third group served as controls. The experiments were undertaken in general anaesthesia. Regional blood flow of the lower urinary tract was measured with 141Ce-labeled microspheres and plasma volume was assessed by the equilibrium distribution of 125I-labeled fibrinogen in tissues. Peroral treatment with indomethacin caused a significant increase in blood flow in the trigone. No difference in whole bladder blood flow was found and no differences were found among groups with respect to plasma volume.
authors.affiliation: Urological Department K, Aarhus Kommunehospital, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Eika
authors.forename: J
authors.initials: J
authors.lastname: Keller
authors.forename: E S
authors.initials: ES
authors.lastname: Hansen
authors.forename: J
authors.initials: J
authors.lastname: Frøkiaer
mesh_terms: D000818:Animals; D015232:Dinoprostone / Q000494:pharmacology*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D014551:Urinary Tract / Q000098:blood supply*
chemical_list: D015232:Dinoprostone; D007213:Indomethacin