[Differentiated study of specific antibody populations as a possible way to increase the prognostic value of indicators of humoral immunity in influenza].
The article overviews the literature and original research data on the ways to increase the informative value of assessed parameters of the humoral immune response to viral disease formation. The need to analyse the heterogeneity of specific IgG class antibodies by their affinity index and to determine the level of circulating specific immune complexes is discussed. It is demonstrated that the value of the humoral immunity studies in influenza-virus infection may be significantly increased by investigating not only the accumulation of circulating immunoglobulins of various classes but the antibody affinity within its class and by assessing the proportions of circulating and immune-complex-bound antibodies. This allows for considering the humoral immunity as a constituent of the interrelated and interdependent immunity mechanism complex.
Meringova
L F
LF
Iakovleva
I V
IV
Voĭtsekhovskiĭ
B L
BL
Dukhin
A I
AI
Poliak
R Ia
RIa
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology*; D000915:Antibody Affinity / Q000276:immunology*; D000918:Antibody Specificity / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology*; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D011379:Prognosis
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D007074:Immunoglobulin G
Differentsirovannoe izuchenie populiatsii spetsificheskikh antitel kak vozmozhnyĭ pu't povysheniia prognosticheskoĭ znachimosti poka- zateleĭ gumora'lnogo immuniteta pri grippe.