[Study of huoxue-huayu in treating experimental intraocular hemorrhage by electroretinography].
Experiments were conducted in chinchilla rabbits to determine the effect of Huoxue-Huayu (promote blood circulation to remove blood stasis) on the electroretinogram (ERG). An animal model of intraocular hemorrhage was established by radiating of Q-switched ruby laser in 58 eyes of 39 rabbits. After laser radiation, the amplitudes of ERGs of the animal eyes were remarkably reduced. The animals were randomly divided into 3 groups. One group was the control group without any treatment. The other two groups were treated with Yandi Decoction III, a composite prescription of Huoxue-Huayu) and urokinase respectively for 3 weeks. The depressed ERGs in the Yandi Decoction III treated group showed remarkable recovery during 6 weeks after starting treatment, comparing with that in the control group and the urokinase treated group (P less than 0.05). Finally, the 33% of the lost amplitude of a-wave and 28% of b-wave in the Yandi Decoction III treated group were recovered. The mechanism of ERG recovery in the Huoxue-Huayu therapy was also preliminarily discussed in the paper.
Duan
J G
JG
Deng
Y P
YP
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004596:Electroretinography; D005130:Eye Hemorrhage / Q000188:drug therapy*; D005260:Female; D008297:Male; D011817:Rabbits; D012160:Retina / Q000503:physiopathology
D004365:Drugs, Chinese Herbal