[Antigenic characteristics of influenza B virus strains isolated in an orphanage during an influenza outbreak in Moscow in the winter of 1988].
Examinations of ARD patients in an orphanage for defective children in Moscow during an influenza outbreak in the winter of 1988 yielded 12 influenza virus strains, including 6 influenza B strains and 6 influenza A (H3N2) strains. The antigenic analysis of hemagglutinin of influenza B virus isolates showed that with respect to the B/Leningrad/179/86 strain (an antigenic analogue of B/Ann Arbor/1/86 strain recommended for inclusion into the influenza vaccine for 1987-1988) they could be divided into 2 groups: antigenically close to the B/Leningrad/86 strain (isolate B/712) and markedly differing from it (the remaining isolates). As compared with reference strains of the previous years, all the new virus isolates fell into 4 groups: isolate B/712 antigenically related to B/Hong Kong/73 and B/Leningrad/86 strains; B/722 antigenically close to B/Singapore/222/79 and B/USSR/100/83 strains; B/724, an antigenic analogue to B/USSR/100/83; and the remaining isolates, to some or other extent, differing from various reference strains. This attests to simultaneous circulation of various antigenic variants of influenza B virus during the 1988 winter outbreak of influenza in Moscow. An interesting feature of the B/712/88 isolate consists in its antigenic specificity of hemagglutinin being indistinguishable from that of B/Hong Kong/8/73 strains.
Reĭzin
F N
FN
Mart'ianova
L I
LI
Malyshkina
L P
LP
Chumakov
M P
MP
D000956:Antigens, Viral / Q000276:immunology* / Q000302:isolation & purification; D002648:Child; D002674:Child, Institutionalized; D004196:Disease Outbreaks; D006389:Hemagglutinins, Viral / Q000032:analysis; D006801:Humans; D009981:Influenza B virus / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology* / Q000382:microbiology; D009031:Moscow
D000956:Antigens, Viral; D006389:Hemagglutinins, Viral
Antigennaia kharakteristika shtammov virusa gripa B, izolirovannykh v detskom dome-internate pri vspyshke grippa v Moskve zimoĭ 1998 g.