Effect of anaesthetic ether on lipid peroxidation and superoxide dismutase isozymes of young and adult rat brain.
Changes in lipid peroxidation and superoxide dismutase level in rat brain due to single exposure to diethyl ether (anaesthetic) were studied in 100 and 300 day old rats. Enhancement of superoxide dismutase activity was more pronounced in young rat brain, while the reverse was the case with lipid peroxidation. The neurotoxic effects of diethyl ether may involve active oxygen species and superoxide dismutase activity increases as a defensive adaptation.
Awasthi
S
S
Kakkar
P
P
Viswanathan
P N
PN
Bharadwaj
R
R
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D004987:Ethers / Q000494:pharmacology*; D007527:Isoenzymes / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism*
D004987:Ethers; D007527:Isoenzymes; D013482:Superoxide Dismutase