Appearance of C-reactive protein (CRP) in serum and liver cytosol of cadmium-treated rats.
The possibility of stimulation of C-reactive protein (CRP) due to inflammation and necrosis caused by cadmium was investigated. Cadmium injection (less than 3 mg/kg body weight) in white rat was found to be associated with the appearance of CRP in liver cytosol after 8 hr and in serum after 18 hr of injection. Although, no definite dose-response relationship was found, yet CRP level was elevated drastically, varying from 1-4 mg/g wet weight liver and 0.3-0.7 mg/ml serum. CRP-positive serum from Cd-treated rats precipitated with normal rat serum on agarose-covered slides in the presence of 1 mM CaCl2. Evidences for raised level of CRP indicates acute tissue damage in the animal.
Agrawal
A
A
Bhattacharya
S
S
D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism*; D002104:Cadmium / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D002104:Cadmium; D002097:C-Reactive Protein