Predicting the range of plasma carbamazepine concentrations in patients with epilepsy.
A statistical model is proposed for predicting the range of plasma carbamazepine concentrations after administration of a controlled-release formulation at steady state. The model is based on previous clinical studies in patients with epilepsy. The predicted range may be used to monitor and adjust treatment in a patient.
Racine-Poon
A
A
Mathematical Applications, CIBA-GEIGY AG, Switzerland.
Dubois
J P
JP
D002220:Carbamazepine / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D015233:Models, Statistical
D003692:Delayed-Action Preparations; D002220:Carbamazepine