title: Interleukin-1 and interleukin-1 inhibitor production by human adherent cells stimulated with periodontopathic bacteria.
abstract: This study examined the effect of the putative periodontopathic bacteria Bacteroides gingivalis and Fusobacterium nucleatum on the production of interleukin-1 (IL-1) and IL-1 inhibitors by human plastic-adherent mononuclear cells from normal donors. Fusobacterium mortiferum was used as a non-oral, non-pathogenic control organism. Unstimulated adherent cells spontaneously secreted an IL-1 inhibitor, whereas stimulation with B. gingivalis induced the synthesis and secretion of IL-1. With both fusobacteria IL-1 was present in the intracellular environment, whereas the predominant secretory product was either IL-1 or an IL-1 inhibitor. These results suggest that bacteria are capable of modulating cytokine production by monocytes and may thereby alter the local immune response.
authors.affiliation: Department of Social & Preventive Dentistry, University of Queensland Dental School, Brisbane, Australia.
authors.forename: L J
authors.initials: LJ
authors.lastname: Walsh
authors.forename: F
authors.initials: F
authors.lastname: Stritzel
authors.forename: K
authors.initials: K
authors.lastname: Yamazaki
authors.forename: P S
authors.initials: PS
authors.lastname: Bird
authors.forename: E
authors.initials: E
authors.lastname: Gemmell
authors.forename: G J
authors.initials: GJ
authors.lastname: Seymour
mesh_terms: D000328:Adult; D001439:Bacteroides / Q000276:immunology*; D002448:Cell Adhesion; D002478:Cells, Cultured; D005260:Female; D005673:Fusobacterium / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008222:Lymphokines / Q000096:biosynthesis*; D008297:Male; D010510:Periodontal Diseases / Q000382:microbiology*
chemical_list: D007375:Interleukin-1; D008222:Lymphokines