Changes in the water holding capacity of psoriatic stratum corneum in vivo.
This study investigated the functional capacity of the stratum corneum of psoriatic skin to bind water in vivo during a relatively long period of time (water holding capacity--WHC). An electrical capacitance test was applied to the psoriatic skin on the elbows, perilesional skin and apparently normal skin of 11 patients and the elbows of 10 controls. Measurements of electrical capacitance were performed using a Corneometer Schwarzhaupt for 25 min. The WHC levels were calculated for this period. Our results demonstrate that the WHC of psoriatic stratum corneum does not differ from controls in the first 10 min. Only after the 20th min do the WHCs differ significantly (p less than 0.02). Despite the biochemical keratin changes in psoriatic plaque, the latter is highly hygroscopic, in particular in the first minute after bathing. Perilesional skin binds water like the stratum corneum of controls, though not beyond the 20th minute after bathing.
Borroni
G
G
Department of Human and Hereditary Pathology, University of Pavia, Italy.
Vignati
G
G
Brazzelli
V
V
Vignoli
G P
GP
Gabba
P
P
Gatti
M
M
Berardesca
E
E
Cosseta
A
A
Rabbiosi
G
G
D000328:Adult; D001834:Body Water; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000503:physiopathology*; D012867:Skin / Q000503:physiopathology*; D013997:Time Factors