title: Experimental evaluation of low-viscosity fluorosilicone oil as a temporary vitreous substitute.
abstract: Fluorosilicone oil, a high specific gravity fluorinated silicone oil, has been recently reevaluated for temporary use in surgery to repair complicated retinal detachments. We evaluated the toxicity of a low-viscosity (300 centistokes) fluorosilicone oil as a vitreous substitute in vitrectomized eyes of albino rabbits. No toxicities could be demonstrated by histopathologic and electroretinographic examinations 6 weeks following surgery. In vitro experiments also showed no toxic effects on cultured retinoblastoma cells. When fluorosilicone oil was injected into the anterior chamber, endothelial cell damage could be seen 2 weeks following injection. Low-viscosity fluorosilicone oil appears to be a safe vitreous substitute for temporary use; it is easily injected and removed, and it maintains adequate surface tension for intraocular tamponade. Because of its relative low viscosity, 300-cst fluorosilicone oil (FS) may be a better vitreous substitute than perfluorocarbon liquids for both intraoperative manipulation of the retina and short-term intraocular tamponade for complicated retinal detachments.
authors.affiliation: National Taiwan University Hospital, Taipei.
authors.forename: K R
authors.initials: KR
authors.lastname: Liu
authors.forename: G A
authors.initials: GA
authors.lastname: Peyman
authors.forename: M V
authors.initials: MV
authors.lastname: Miceli
mesh_terms: D000818:Animals; D004728:Endothelium, Corneal / Q000187:drug effects / Q000648:ultrastructure; D005069:Evaluation Studies as Topic; D007267:Injections; D008422:Materials Testing; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000648:ultrastructure; D012827:Silicone Oils / Q000008:administration & dosage / Q000633:toxicity; D014407:Tumor Cells, Cultured; D014821:Vitrectomy; D014822:Vitreous Body
chemical_list: D012827:Silicone Oils; C054077:fluorosilicone oil