Pre-natal (segment II) toxicity study of cinnamic aldehyde in the Sprague-Dawley rat.
Cinnamic aldehyde (CA) was administered by gavage to Sprague-Dawley rats on days 7-17 of pregnancy at doses of 5,25 or 250 mg/kg body weight/day. Significantly lower weight gain of the dams was observed at the two higher dose levels. No significant dose-related increase of abnormalities was observed: the incidence of poor cranial ossification was significantly increased in all treated groups, while reduced ossification of the tympanic bulla was increased at 25 or 250 mg/kg/day. Significant increases of the incidences of dilated pelvis/reduced papilla in the kidney, dilated ureters and greater than or equal to 2 abnormal sternebrae per foetus were detected in the 2-mg/kg group, which had the highest overall prevalence of minor abnormalities. Since significant increases in the incidences of reduced cranial ossification, dilated ureters and renal variants were observed at 5 mg/kg, a dose at which there was no detectable maternal toxicity, it is suggested that the foetus might be slightly more sensitive than the adult to the action of CA.
Mantovani
A
A
Laboratorio di Tossicologia Comparata ed Ecotossicologia, Istituto Superiore di Sanità, Rome, Italy.
Stazi
A V
AV
Macri
C
C
Ricciardi
C
C
Piccioni
A
A
Badellino
E
E
D000171:Acrolein / Q000031:analogs & derivatives / Q000633:toxicity*; D000447:Aldehydes / Q000633:toxicity*; D000818:Animals; D001842:Bone and Bones / Q000002:abnormalities; D005260:Female; D005421:Flavoring Agents / Q000633:toxicity*; D010012:Osteogenesis / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013723:Teratogens; D014551:Urinary Tract / Q000002:abnormalities
D000447:Aldehydes; D005421:Flavoring Agents; D013723:Teratogens; D000171:Acrolein; C012843:cinnamaldehyde