[Monoclonal antibody in the detection of neuroblastoma cells in bone marrow aspirates].
Reaction of monoclonal antibody F3 against neuroblastoma cells, normal blood cells and hematopoietic cells, as well as various leukemic cells were studied by indirect immunofluorescence stain. It was found that F3 antibody reacted with neuroblasts and relatively matured myeloid cells only. The detection of neuroblasts in marrow aspirates by this antibody conformed well with the clinical diagnosis of neuroblastoma. Therefore, this antibody may be useful in the diagnosis of neuroblastoma. Measures to improve the sensitivity of this immunodiagnostic method are also discussed.
Bai
Y
Y
Institute of Basic Medical Sciences, Academy of Military Medical Sciences.
D000911:Antibodies, Monoclonal / Q000032:analysis*; D000912:Antibodies, Neoplasm / Q000276:immunology; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D009447:Neuroblastoma / Q000175:diagnosis* / Q000556:secondary
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm