New fluorinated carbocyclic nucleosides: synthesis and bioactivity.
Novel fluorinated carbocyclic nucleosides, (+-)-3'-deoxy-3'-fluoroaristeromycin and (+-)-2',3'-dideoxy-3'-fluoroaristeromycin have been synthesized. The antitumor activities of these compounds were studied.
Nakayama
T
T
Research Center, Asahi Grass Co., Ltd., Yokohama, Japan.
Morizawa
Y
Y
Matsumura
Y
Y
Yasuda
A
A
Uchida
K
K
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; C062349:2',3'-dideoxy-3'-fluoroaristeromycin; C062348:3'-deoxy-3'-fluoroaristeromycin; D000241:Adenosine