Albendazole is effective against established Echinococcus granulosus in gerbils: comparison of serum concentrations achieved by gavage and feed administration.
Serum levels of albendazole sulphoxide in gerbils infected with Echinococcus granulosus and treated with albendazole (20 or 50 mg kg-1 day-1) by gavage were dose dependent, whereas albendazole administered in feed at a rate equivalent to 80 mg kg-1 day-1 achieved serum levels calculated to be equivalent to those produced by administration of 40 mg kg-1 day-1 by gavage. This regimen, over a three-month period, was effective and reduced parasite weight to 4.6% of that in control gerbils, and the treated parasite tissue showed ultrastructural changes ranging from severe accumulation of residual bodies to total disintegration of the germinal layer.
Taylor
D H
DH
Department of Surgery, University Hospital, Nottingham, U.K.
Morris
D L
DL
Richards
K S
KS
D000284:Administration, Oral; D015766:Albendazole / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000821:Animal Feed; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004443:Echinococcosis / Q000188:drug therapy*; D004446:Echinococcus / Q000187:drug effects / Q000648:ultrastructure; D005849:Gerbillinae; D008854:Microscopy, Electron
D015766:Albendazole