title: Antibacterial effects of glass ionomers.
abstract: Glass ionomer cements have been shown to possess antimicrobial activity. Proposed mechanisms of action include acidity and fluoride. It was the purpose of this study to determine the antimicrobial effect of 11 glass ionomer cements, their individual powder and liquid components and one resin-bonded liner containing high fluoride ionomer glass against Streptococcus mutans #6715. The role of fluoride and pH in the antibacterial activity was also studied. Using agar diffusion assay methodology, the following results were obtained. All of the glass ionomer cements were inhibitory against S. mutans. The antibacterial cements and slurries that were tested for fluoride, released the ion in excess of reported minimum inhibitory values. The antimicrobial activity of the liquid components, that were tested for the effects of pH changes, was totally lost when the pH was adjusted to 5. The resin bonded liner was inactive against S. mutans and did not release inhibitory concentrations of fluoride. These results indicate that freshly-mixed glass ionomer cements are antimicrobial against S. mutans and that the mechanism of action is probably a function of both fluoride and pH although additional factors may be involved.
authors.forename: E J
authors.initials: EJ
authors.lastname: DeSchepper
authors.forename: R R
authors.initials: RR
authors.lastname: White
authors.forename: W
authors.initials: W
authors.lastname: von der Lehr
mesh_terms: D003738:Dental Cements / Q000494:pharmacology*; D005459:Fluorides / Q000633:toxicity; D005899:Glass Ionomer Cements / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D013295:Streptococcus mutans / Q000187:drug effects*
chemical_list: D003738:Dental Cements; D005899:Glass Ionomer Cements; D005459:Fluorides