title: Experimental selenium toxicity in guinea pigs: haematological studies.
abstract: Haematological studies were conducted in recently weaned guinea pigs fed selenium-enriched barley (organic selenium) and barley mixed with sodium selenite (inorganic selenium). An attempt was made to study the effect of sodium arsenite supplementation in sodium selenite toxicity. A significant (p less than 0.01) decrease was noticed in the mean values of haemoglobin, haematocrit, mean corpuscular haemoglobin and mean corpuscular volume thereby indicating a microcytic hypochromic anaemia. The anaemia was comparatively more marked in guinea pigs fed selenium-enriched barley than in those kept on barley mixed with sodium selenite. There was a significant decrease in total leucocyte count which was the result of lymphocytopenia in organic toxicity and a decrease in both neutrophils and lymphocytes in inorganic toxicity. Dietary supplementation with sodium arsenite resulted in less reduction in the mean values of different erythrocytic indices thereby indicating that addition of sodium arsenite has some protective effect against toxicity with sodium selenite.
authors.affiliation: Department of Veterinary Pathology, Haryana Agricultural University, Hisar, India.
authors.forename: P M
authors.initials: PM
authors.lastname: Das
authors.forename: J R
authors.initials: JR
authors.lastname: Sadana
authors.forename: R K
authors.initials: RK
authors.lastname: Gupta
authors.forename: R P
authors.initials: RP
authors.lastname: Gupta
mesh_terms: D000747:Anemia, Hypochromic / Q000097:blood* / Q000139:chemically induced; D000818:Animals; D001151:Arsenic / Q000633:toxicity; D018053:Arsenites; D001772:Blood Cell Count; D004909:Erythrocyte Indices; D006168:Guinea Pigs; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D012643:Selenium / Q000633:toxicity*; D017670:Sodium Compounds
chemical_list: D018053:Arsenites; D006454:Hemoglobins; D017670:Sodium Compounds; C017947:sodium arsenite; D012643:Selenium; D001151:Arsenic