[Effect of acoustic stress on immunoregulatory cells in female patients with systemic lupus erythematodes (SLE), patients with sarcoidosis and normal comparative subjects].
14 patients with systemic lupus erythematosus (SLE), 12 with sarcoidosis and two age- and sex-matched groups of healthy subjects were exposed to a 10-minute acoustic stress test. Healthy subjects and patients with sarcoidosis showed significant increases in leukocyte and lymphocyte counts (p less than 0.01), relative elevations of B and Tsc lymphocytes (p less than 0.01) and a relative reduction of Th lymphocytes (p less than 0.01). Patients with SLE showed the same characteristic alterations (p less than 0.01) but the degree of this cell mobilization was significantly less pronounced as compared with the healthy subjects (p less than 0.01). No dependence was found between corticosteroid therapy or disease activity and the cellular reaction in SLE patients. In SLE patients there thus seemed to be an attenuated immune response due to stress which may play an etiopathogenetic role in this disease.
Hinrichsen
H
H
I. Medizinische Klinik, Christian-Albrechts-Universität, Kiel, (BRD).
Barth
J
J
Ferstl
R
R
Kirch
W
W
D000161:Acoustic Stimulation; D000328:Adult; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008214:Lymphocytes / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000276:immunology*
Einfluss von akustischem Stress auf immunregulatorische Zellen bei Patientinnen mit systemischem Lupus erythematodes (SLE), Patienten mit Sarkoidose und gesunden Vergleichspersonen.