Biodistribution and dosimetry of 3F8 neuroblastoma monoclonal antibody.
A method has been developed for quantitating radiolabeled antibody concentrations from images obtained with standard gamma cameras. The method is based on orthogonal projections and accounts both for the effective attenuation of gamma rays and the finite depth dependent resolution of a gamma camera. The method was verified in experimental phantoms and subsequently used in patient studies to quantitate radiolabeled antibody concentrations in neuroblastoma tumors. The in vivo measurements of tumor radioactivity levels were confirmed at biopsy in one patient.
Nelson
A D
AD
Department of Radiology, University Hospitals of Cleveland, Ohio 44106.
Miraldi
F
F
Cheung
N K
NK
D000911:Antibodies, Monoclonal; D006801:Humans; D007457:Iodine Radioisotopes; D008961:Models, Structural; D008962:Models, Theoretical; D009447:Neuroblastoma / Q000000981:diagnostic imaging*; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes