Effects of a high-linoleate and a high-alpha-linolenate diet on spontaneous mammary tumourigenesis in mice.
SHN mice were fed a high-linoleate diet, a high-alpha-linolenate diet or a control diet. Spontaneous mammary tumourigenesis was significantly inhibited in the high alpha-linolenate group compared to the other two groups, while little difference was observed among groups in the rates of lung metastasis. The dietary alpha-linolenate/linoleate balance affected the fatty acid patterns of tissue lipids. The triacylglycerol/phospholipid ratios and the fatty acid patterns were significantly different between the mammary glands and the mammary tumours. The results indicate that the dietary alpha-linolenate/linoleate balance affects the fatty acid composition and, in turn, spontaneous mammary tumourigenesis in mice.
Kamano
K
K
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Okuyama
H
H
Konishi
R
R
Nagasawa
H
H
D000818:Animals; D000970:Antineoplastic Agents; D004041:Dietary Fats / Q000627:therapeutic use*; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000627:therapeutic use*; D008042:Linolenic Acids / Q000627:therapeutic use*; D008297:Male; D008321:Mammary Glands, Animal / Q000032:analysis; D008325:Mammary Neoplasms, Experimental / Q000032:analysis / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D008815:Mice, Inbred Strains; D012016:Reference Values; D014280:Triglycerides / Q000032:analysis
D000970:Antineoplastic Agents; D004041:Dietary Fats; D005227:Fatty Acids; D008041:Linoleic Acids; D008042:Linolenic Acids; D014280:Triglycerides; D019787:Linoleic Acid