A new index for collagen induced platelet aggregation.
In this paper, we propose a new index of platelet aggregation for optical aggregometry, the "R" value. This represents the rate of change in the half time for platelet aggregation (T1/2) induced by collagen with changes in the platelet concentration and expresses the degree of platelet sensitivity to collagen. The "R" value has been shown to reflect the aggregability of platelets due to activation of the contact factors. The "R" values were significantly different in the acute and chronic phases of occlusive arterial disease, while ordinary platelet aggregation parameters did not change. A decrease in the "R" value appears to indicate a platelet hyperfunction and hypercoagulable state, in other words a prethrombotic state.
Kakishita
E
E
Second Department of Internal Medicine, Hyogo College of Medicine, Japan.
Higuchi
M
M
Suehiro
A
A
Nagai
K
K
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000097:blood*; D001792:Blood Platelets / Q000187:drug effects; D003094:Collagen / Q000494:pharmacology*; D004198:Disease Susceptibility; D004610:Ellagic Acid / Q000494:pharmacology; D005174:Factor XII / Q000378:metabolism; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D010976:Platelet Count; D010979:Platelet Function Tests; D011817:Rabbits; D013927:Thrombosis / Q000097:blood
D004610:Ellagic Acid; D000244:Adenosine Diphosphate; D005174:Factor XII; D003094:Collagen