A new synthetic peptide with elastase inhibiting effect.
A new peptide, obtained by chemical synthesis, inhibits porcine pancreatic elastase activity "in vitro" with an IC50 of 24 mmol/l. The effect of the peptide was also tested on human plasma elastase by using plasmas with different levels of alpha-1-antitrypsin. The synthetic peptide apparently decreased the amount of normal plasma elastase, assayed by an immunoenzymatic method, with a dose-dependent effect and an IC50 of 13 mmol/l. In plasma with higher amounts of alpha-1-antitrypsin the IC50 value was 18 mmol/l.
Galzigna
L
L
Institute of Biological Chemistry, University of Padova, Italy.
Marchiori
F
F
Celadin
M
M
Burlina
A
A
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D010179:Pancreas / Q000201:enzymology; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors* / Q000097:blood; D010455:Peptides / Q000494:pharmacology*; D013552:Swine
D010455:Peptides; D010196:Pancreatic Elastase