Metabolism of metapramine in vitro by chemical model systems and rat liver microsomes.
Metapramine (Timaxel) was oxidised by hepatic microsomes from rat and by biomimetic chemical systems; vanadyl acetylacetonate-iodylbenzene, phthalocyanin-iron II-iodosylbenzene, meso tetraphenyl porphyrine-iron III chloride-iodosylbenzene and Fenton's reagent. The major metabolite in all cases was the monodemethylated product formed by oxydative removal of the methyl group on the endocyclic nitrogen atom.
Barret
R
R
Laboratoire de Chimie Organique, Faculté de Pharmacie de Lyon, France.
Jaussaud
P
P
Pautet
F
F
Guyot
J L
JL
Daudon
M
M
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000378:metabolism*; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D003984:Dibenzazepines / Q000378:metabolism*; D005557:Formaldehyde / Q000378:metabolism; D006861:Hydrogen Peroxide; D007501:Iron; D008297:Male; D008665:Metalloporphyrins; D008862:Microsomes, Liver / Q000378:metabolism*; D008956:Models, Chemical; D010084:Oxidation-Reduction; D051381:Rats
D000929:Antidepressive Agents, Tricyclic; D003984:Dibenzazepines; C045076:Fenton's reagent; D008665:Metalloporphyrins; C032547:iron tetraphenylporphyrin; D005557:Formaldehyde; C012677:metapramine; D006861:Hydrogen Peroxide; D007501:Iron