Termination of early pregnancy using mifepristone in combination with prostaglandin analogs.
Mifepristone, (RU 486), is an antiprogesterone which, when administered alone will terminate early pregnancy in 80% of cases. Prostaglandins at high doses have also been used to terminate pregnancy but there are often unacceptable side effects. The combined treatment of mifepristone with low doses of prostaglandin analogs appears to be an effective method for termination of pregnancy, with a high success rate and a reduction in the side effects observed with prostaglandins.
Maria
B
B
Départment de Gynécologie-Obstétrique, Université de Paris, Val de Marne, Centre Hospitalier, Villeneuve-Saint-Georges, France.
Stampf
F
F
D015064:16,16-Dimethylprostaglandin E2 / Q000008:administration & dosage* / Q000031:analogs & derivatives; D000019:Abortifacient Agents / Q000008:administration & dosage*; D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000028:Abortion, Induced; D000328:Adult; D015232:Dinoprostone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage*
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D011459:Prostaglandins E, Synthetic; C025505:meteneprost; D015735:Mifepristone; C016767:sulprostone; D015232:Dinoprostone; D015064:16,16-Dimethylprostaglandin E2