[Effects of serotonin and stress on the state of the gastric mucosa in rats with the intact and transsected vagus nerve].
In experiments on vagotomized and intact rats with the use of two models of experimental gastric ulceration (injection of serotonin and stress) it was demonstrated that the inhibitory action of vagotomy on haemorrhagic gastric effectiveness was more pronounced in stress than after serotonin application. Vagotomy decreased stress-induced erosive lesions but increased serotonin-induced erosions that may be a result of the increase of gastric tissue sensitivity to this amine which developed simultaneously with significant decrease of its level in gastric wall after vagotomy. Serotonin-antagonist peritol decreased stress-induced gastric disturbances in vagotomized rats more significantly than in intact rats; this suggested the great role of serotonin in anti-ulcerogenic effect of vagotomy.
Karevina
T G
TG
Khokholia
V P
VP
Shevchuk
I M
IM
D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D008297:Male; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced / Q000209:etiology; D051381:Rats; D012701:Serotonin / Q000008:administration & dosage / Q000009:adverse effects*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000473:pathology*; D013312:Stress, Physiological / Q000150:complications; D015167:Vagotomy, Truncal
D003533:Cyproheptadine; D012701:Serotonin
Vliianie serotonina i stressa na sostoianie slizistoĭ obolochki zheludka u krys s intaktnymi i pererezannymi bluzhdaiushchimi nervami.