Nonathymulin treatment of multiple sclerosis: double-blind pilot study.
We carried out a randomized, double-blind, placebo-controlled trial of Nonathymulin (NT, synthetic serum thymic factor) in patients with evolutive multiple sclerosis (MS) and moderate disability. Forty matched patients were treated with subcutaneous NT or placebo for 6 months and followed for another 6 months. There was no significant difference in treatment and control groups in the Kurtzke. Disability scores, Ambulation Index and Functional Scale. No significant side effects were recorded. NT is not effective in treating evolutive and moderately disabled MS.
Roullet
E
E
Multiple Sclerosis Clinic, Hpital Saint-Antoine, Paris, France.
Cesaro
P
P
Simon-Lavoine
N
N
Degos
J D
JD
Marteau
R
R
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D013935:Thymic Factor, Circulating / Q000009:adverse effects / Q000627:therapeutic use*; D013951:Thymus Hormones / Q000627:therapeutic use*
D013951:Thymus Hormones; D013935:Thymic Factor, Circulating