[The effect of neomycin on the contractile activity of the skeletal muscles in the frog].
Neomycin, a selective inhibitor of the phosphoinositide metabolism, depending on its concentration and the incubation time, depressed the K+-contractures and contractions of m. sartorius R. ridibunda caused by a single or a tetanic electrostimulation. In the experiments on m. rectus abdominis, neomycin inhibited the Ach- and oubaine contractures but not the K+ ones. The contractures of both muscles induced with caffeine did not change in presence of the above antibiotic. The data obtained suggest a participation of phosphoinositides contractions of skeletal muscles induced by excitation of the plasma membrane.
Danilenko
M P
MP
Pak
A D
AD
Esyrev
O V
OV
Abilova
S N
SN
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004558:Electric Stimulation; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009355:Neomycin / Q000494:pharmacology*; D010042:Ouabain / Q000494:pharmacology; D011895:Rana ridibunda; D013997:Time Factors
D002110:Caffeine; D010042:Ouabain; D009355:Neomycin; D000109:Acetylcholine
Vliianie neomitsina na sokratitel'nuiu aktivnost' skeletnykh myshts liagushki.