title: Estimation of the in vitro and in vivo inhibitory effects of antifolates upon thymidylate synthase (TS) in whole cells.
authors.affiliation: Inst. Cancer Res. Drug Development Section, Sutton, Surrey, UK.
authors.forename: G A
authors.initials: GA
authors.lastname: Taylor
authors.forename: A L
authors.initials: AL
authors.lastname: Jackman
authors.forename: K
authors.initials: K
authors.lastname: Balmanno
authors.forename: L R
authors.initials: LR
authors.lastname: Hughes
authors.forename: A H
authors.initials: AH
authors.lastname: Calvert
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005492:Folic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D005493:Folic Acid Antagonists / Q000493:pharmacokinetics / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000201:enzymology*; D051379:Mice; D008811:Mice, Inbred DBA; D011799:Quinazolines / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D013997:Time Factors; D014407:Tumor Cells, Cultured
chemical_list: D005493:Folic Acid Antagonists; D011799:Quinazolines; C025928:CB 3705; C031662:CB 3717; D005492:Folic Acid; D013940:Thymidylate Synthase