Sensitivity of yeasts to amphotericin B and 5-fluorocytosine.
One hundred and forty-four clinical yeast isolates were tested for antifungal susceptibility to Amphotericin B (AMB) and 5-Fluorocytosine (5FC). 61% (88 of 144) of the total yeast isolates were C. albicans. Yeasts were most frequently isolated from high vaginal swabs. High vaginal swabs constituted 64% (92 of 144) of the total number of specimens. Antifungal susceptibility testing of yeasts was conducted by employing an agar dilution technique. 76% (67 of 88) of C. albicans demonstrated MIC values of less than or equal to 1.0 ug/ml to 5FC. All yeasts tested against AMB demonstrated MICs of less than or equal to 0.25 ug/ml. Resistance to 5FC and AMB was defined as any isolate demonstrating an MIC of greater than 16 ug/ml and MIC greater than or equal to 2 ug/ml respectively. Based on this definition approximately 6% of total yeasts and 8% of C. albicans were resistant to 5FC. All yeasts tested were sensitive to AMB.
Abdul-Samad
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Arumugham
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Yasin
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D000666:Amphotericin B / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D015169:Colony Count, Microbial; D004352:Drug Resistance, Microbial; D005437:Flucytosine / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests
D000666:Amphotericin B; D005437:Flucytosine