title: Echocardiographic evaluation of vagolytic effects of hyoscine butylbromide in paediatric halothane anaesthesia.
abstract: The effects of vagolysis with hyoscine butylbromide on left ventricular function were evaluated by echocardiography during halothane anaesthesia in children. Echocardiography showed deterioration of the following values after halothane induction; pre-ejection period, systolic time interval, left ventricular shortening fraction and ejection fraction. The first two values were improved by vagolysls with hyoscine butylbromide. However, relatively rate-independent indices, i.e. left ventricular shortening fraction and ejection fraction, still remained depressed even after vagolysis with hyoscine butylbromide. This implies that halothane-induced myocardial depression can only be partially antagonized by vagolysis.
authors.forename: M
authors.initials: M
authors.lastname: Yamashita
authors.forename: H
authors.initials: H
authors.lastname: Horigome
mesh_terms: D000769:Anesthesia, Inhalation; D002086:Butylscopolammonium Bromide / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D006221:Halothane; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D012602:Scopolamine Derivatives / Q000494:pharmacology*; D014630:Vagus Nerve / Q000187:drug effects*
chemical_list: D012602:Scopolamine Derivatives; D002086:Butylscopolammonium Bromide; D006221:Halothane