Does kallikrein improve the brain function in dementia?
Forty biological units of Kallikrein were administered intramuscularly to nine persons suffering from multi-infarct dementia. With automatic analysis equipment, the wave-form recognition method was used to analyze EEG before injection, immediately after injection, and 30, 60, 90, and 120 minutes after injection. The results of analysis done the five times after injection were then compared with the analysis results before injection. With the passage of time after injection, delta and theta waves showed a gradually decreasing tendency, while alpha and beta waves showed a gradual increase. It was inferred that these changes in the EEG were caused by an increase in the flow of cerebral blood, which in turn was the effect of the dilatation of cerebral blood vessels resulting from the action of the Kallikrein.
Ishizuka
Y
Y
Department of Psychiatry, Yamanashi Medical College, Japan.
Fukuzawa
H
H
Asada
T
T
Kariya
T
T
D000368:Aged; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D002544:Cerebral Infarction / Q000150:complications / Q000503:physiopathology*; D003704:Dementia / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D004569:Electroencephalography; D006801:Humans; D007610:Kallikreins / Q000627:therapeutic use*; D013826:Theta Rhythm / Q000187:drug effects
D007610:Kallikreins