title: Poststress effects of danger and safety signals on gastric ulceration in rats.
abstract: Gastric ulceration of rats stressed by restraint in 19 degrees C water for 75 min was markedly increased by allowing a 75-min postrestraint room-temperature rest period during which the rat was exposed to cues that had previously been associated with the delivery of 80 5-s uncontrollable electric shocks distributed over four sessions. This effect obtained equally without regard to whether the "danger cues" were punctate signals or constant contextual cues or whether contextual ones were interrupted by punctate safety signals. The experimental treatments used were unusual in that they equated the groups on their total conditioning history and thus allowed a more pure look at the poststress effect than heretofore. Other groups provided controls for prior shocks, rest, and their interaction as well as handling. Analyses of corticosterone after the stress or stress-rest cycle revealed only a general decline in corticosterone levels with rest undifferentiated across groups.
authors.affiliation: Center for Research in Learning Perception and Cognition, University of Minnesota, Minneapolis 55455.
authors.forename: J B
authors.initials: JB
authors.lastname: Overmier
authors.forename: R
authors.initials: R
authors.lastname: Murison
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology*; D003345:Corticosterone / Q000097:blood; D005753:Gastric Mucosa / Q000294:innervation; D008297:Male; D010275:Parasympathetic Nervous System / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology
chemical_list: D003345:Corticosterone