NIH3T3 transforming gene not a general feature of atherosclerotic plaque DNA (atherosclerosis/oncogene/NIH3T3 transfection assay).
A recent study indicated that the DNA isolated from human coronary atherosclerotic lesions is capable of transforming NIH3T3 cells in culture. Using DNA isolated from rabbit aortic and human carotid atherosclerotic lesions, we failed to observe such transforming activity. Thus, NIH3T3 transforming activity does not appear to be a general feature of atherosclerotic lesions.
Yew
P R
PR
Department of Medicine, UCLA 90024.
Rajavashisth
T B
TB
Forrester
J
J
Barath
P
P
Lusis
A J
AJ
D000818:Animals; D001161:Arteriosclerosis / Q000235:genetics*; D002339:Carotid Arteries / Q000032:analysis; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D011817:Rabbits; D014162:Transfection; D014407:Tumor Cells, Cultured; D001749:Urinary Bladder Neoplasms / Q000235:genetics
D004247:DNA