title: Serum and gingival tissue antibody levels to oral microbial antigens in human chronic adult periodontitis.
abstract: Antibody levels against antigens from eight oral micro-organisms were measured in sera and gingival tissue extracts from adult periodontitis patients and healthy subjects by an enzyme-linked immunosorbent assay. The antibody levels of diseased serum samples were significantly higher than those of healthy serum samples. Analysis of diseased sera indicated that antibody levels against Bacteriodes gingivalis antigens were significantly higher than antibody levels against all the other antigens tested except for those from B. intermedius and B. asaccharolyticus. Extracts from diseased gingival tissues had significantly higher levels of antibody against B. gingivalis antigens than against antigens from all of the other micro-organisms tested, including B. intermedius and B. asaccharolyticus. These results suggest selective, specific and localized antibody production during or following the establishment of chronic adult periodontitis.
authors.affiliation: Department of Periodontics, Dental School, Northwestern University, Chicago, Illinois 60611-2909.
authors.forename: D W
authors.initials: DW
authors.lastname: Turner
authors.forename: G J
authors.initials: GJ
authors.lastname: Dai
authors.forename: B
authors.initials: B
authors.lastname: Merrell
authors.forename: P J
authors.initials: PJ
authors.lastname: Robinson
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000907:Antibodies, Bacterial / Q000032:analysis*; D000942:Antigens, Bacterial / Q000276:immunology*; D001439:Bacteroides / Q000276:immunology*; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005881:Gingiva / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008875:Middle Aged; D010518:Periodontitis / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007074:Immunoglobulin G