Effect of ethanol and diazepam given to pregnant rats on the behavior and catecholamine content in the brain of offspring.
Effect of separate and combined treatment with ethanol and diazepam applied to pregnant rats upon the behavior of 3- and 6-week old and 3 month old rats, as well as on the content of noradrenaline (NA), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) in various brain areas was investigated. It has been shown that separate application of ethanol and diazepam causes slight changes in the behavior and content of amines on the brain of offsprings. Combined application of ethanol and diazepam to pregnant rats exerts marked effects upon the behavior of offsprings and causes a decreased content mainly of 5-HT and 5-HIAA in the investigated areas of the brain.
Felińska
W
W
Department of Pharmacology, Silesian Academy of Medicine, Zabrze, Poland.
Pyka
U
U
Szkilnik
R
R
Czechowicz
K
K
Siekierska
E
E
Pilśniak
U
U
Brus
R
R
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001679:Biogenic Amines / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism*; D003975:Diazepam / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D009043:Motor Activity / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains
D001679:Biogenic Amines; D002395:Catecholamines; D000431:Ethanol; D003975:Diazepam