[The role of changes in vascular permeability, interstitial relaxation and surface tension forces in the alveoli in disordered filtration-absorption equilibrium in pulmonary edema].
Changes of fluid filtration and reabsorption in application and removal of hydrodynamic loads were studied on isolated lungs of dogs. Some models of transcapillary filtration in the lungs were studied on basis of the obtained data. According to the theoretical predictions of these models, the following factors influence the non-linearity of the filtration and reabsorption processes most essentially: interstitial relaxation in the stage of interstitial edema and the appearance of surface tension forces in the alveoli. The hypothesis of the significance of disturbed permeability of the capillary wall is confirmed to a very small measure with such an approach. The described phenomena allow the processes of fluid accumulation in pulmonary edema to be represented on a mathematical model.
Serikov
V B
VB
Beliakov
N A
NA
D000042:Absorption; D000818:Animals; D002199:Capillary Permeability / Q000502:physiology*; D004285:Dogs; D015633:Extravascular Lung Water / Q000502:physiology; D006874:Hydrostatic Pressure; D066298:In Vitro Techniques; D008433:Mathematics; D008954:Models, Biological; D009119:Muscle Contraction / Q000502:physiology*; D009126:Muscle Relaxation / Q000502:physiology*; D009997:Osmotic Pressure; D011650:Pulmonary Alveoli / Q000503:physiopathology*; D011654:Pulmonary Edema / Q000503:physiopathology*; D013500:Surface Tension
Rol' izmeneniĭ sosudistoĭ pronitsaemosti, relaksatsii interstitsiia i sil poverkhnostnogo natiazheniia v al'veolakh v narushenii fil'tratsionno-absorbtsionnogo ravnovesiia pri oteke legkikh.