Estimation of the in vitro and in vivo inhibitory effects of antifolates upon thymidylate synthase (TS) in whole cells.
Taylor
G A
GA
Inst. Cancer Res. Drug Development Section, Sutton, Surrey, UK.
Jackman
A L
AL
Balmanno
K
K
Hughes
L R
LR
Calvert
A H
AH
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005492:Folic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D005493:Folic Acid Antagonists / Q000493:pharmacokinetics / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000201:enzymology*; D051379:Mice; D008811:Mice, Inbred DBA; D011799:Quinazolines / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D013997:Time Factors; D014407:Tumor Cells, Cultured
D005493:Folic Acid Antagonists; D011799:Quinazolines; C025928:CB 3705; C031662:CB 3717; D005492:Folic Acid; D013940:Thymidylate Synthase