title: Synthesis, antibacterial activity and structure-activity relationships of N-substituted 3-methyl-4-diazo-5-pyrazolecarboxamides.
abstract: A number of N-substituted 3-methyl-4-diazo-5-pyrazolecarboxamides (IVa-p) have been synthesized and tested for their in vitro antibacterial activity. All the compounds have been assayed against several representative Gram-negative and Gram-positive bacteria, as well as against some intestinal bacterial species. Some of the 4-diazopyrazoles IVa-c have shown a quite interesting broad-spectrum activity, while they are ineffective against the "protective" intestinal flora. The structure-activity relationships of the series have been studied quantitatively, via both univariate and multivariate methods: the results are consistent and permit some rationalization of the behaviour of the compounds investigated.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy.
authors.forename: P G
authors.initials: PG
authors.lastname: Baraldi
authors.forename: P
authors.initials: P
authors.lastname: Brigidi
authors.forename: A
authors.initials: A
authors.lastname: Casolari
authors.forename: S
authors.initials: S
authors.lastname: Manfredini
authors.forename: V
authors.initials: V
authors.lastname: Periotto
authors.forename: M
authors.initials: M
authors.lastname: Recanatini
authors.forename: M
authors.initials: M
authors.lastname: Roberti
authors.forename: M
authors.initials: M
authors.lastname: Rossi
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007202:Indicators and Reagents; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001391:Azo Compounds; D007202:Indicators and Reagents; D011720:Pyrazoles