title: [The relation of tryptophan hydroxylase activity in the brain and the manifestation of catalepsy in mice].
abstract: Pinch-induced catalepsy and thyptophan hydroxylase (TPH) activity in striatum and midbrain were determined in male mice of 6 inbred strains. Pronounced catalepsy was found in the only mice strain--CBA. TPH activity in midbrain and especially in striatum of CBA mice was higher than in the strains, which did not display catalepsy. The experimental situation, which promotes the development of highly aggressive CBA males, caused a decrease in TPH activity in striatum and these mice did not express genetic predisposition to catalepsy. The results indicate that TPH activity in striatum is involved in the mechanism of catalepsy in mice.
authors.forename: A V
authors.initials: AV
authors.lastname: Kulikov
authors.forename: N N
authors.initials: NN
authors.lastname: Kudriavtseva
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Kozlachkova
authors.forename: N K
authors.initials: NK
authors.lastname: Popova
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology*; D002375:Catalepsy / Q000201:enzymology* / Q000209:etiology; D003342:Corpus Striatum / Q000201:enzymology; D008297:Male; D008636:Mesencephalon / Q000201:enzymology; D051379:Mice; D008815:Mice, Inbred Strains; D012919:Social Behavior; D013045:Species Specificity; D014365:Tryptophan Hydroxylase / Q000378:metabolism*
chemical_list: D014365:Tryptophan Hydroxylase
vernacular_title: Sviaz' mezhdu aktivnost'iu triptofangidroksilazy v golovnom mozge i proiavleniem katalepsii u mysheĭ.