[The effect of testosterone propionate on energy metabolism indices and the catecholamine content of the vascular wall].
The effect of testosterone propionate (1 mg/kg) on the specific activity of lactate dehydrogenase, malate dehydrogenase, contents of pyruvic and lactic acids, levels of catecholamines in target tissues and non-target tissues of rats was studied. Deficit of androgens and their single compensation by administering testosterone propionate lead to an inhibition of energy formation, a decrease of enzyme activity and contents of metabolites in tissues of the seminal vesicles. The course administration of testosterone propionate increases the activity of malate dehydrogenase in the aorta and myocardium. Acetylsalicylic acid (40 mg/kg) induces an increase of noradrenaline levels in the heart and aorta along with an increase of androgen level in the organism.
Nikulin
A A
AA
Iakusheva
E N
EN
Uzbekova
D G
DG
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology; D001808:Blood Vessels / Q000187:drug effects* / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects*; D006321:Heart / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009919:Orchiectomy; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology*
D002395:Catecholamines; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D013739:Testosterone; D019289:Pyruvic Acid; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D001241:Aspirin
Vliianie testosterona propionata na nekotorye pokazateli énergeticheskogo obmena i soderzhanie katekholaminov v sosudistoĭ stenke.