[The effect of tocopherol and ascorbic acid on the development of experimental esophageal tumors].
The study was concerned with the influence of tocopherol and ascorbic acid on induction of tumors by N-nitrososarcosine ethyl ester (NSEE) in rats. In the first series of experiments, NSEE was given orally in the daily dose of 100 mg/kg body weight during 8 weeks while alpha-tocopherol acetate was administered in the dose of 600 mg/kg food during the following 32 weeks. In the second series, NSEE was given intragastrically in the dose of 50 mg/kg body weight daily during 16 weeks whereas for the following 16 weeks, the animals received 20 g/kg food ascorbic acid. The rats were sacrificed at 40 (series 1) and 32 weeks (series 2) of the experiment. NSEE induced tumors of the esophagus and forestomach in more than 90% of cases, mainly papillomas and--less frequently--carcinomas, five tumors per rat, on the average. Treatment with tocopherol was followed by a 37% decrease in the incidence of esophageal and forestomach tumors, an approximately two-fold drop in their multiplicity as well as by lowered incidence of carcinomas. Ascorbic acid did not affect tumor induction.
Bespalov
V G
VG
Troian
D N
DN
Petrov
A S
AS
Aleksandrov
V A
VA
D000818:Animals; D000970:Antineoplastic Agents; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002273:Carcinogens; D004354:Drug Screening Assays, Antitumor; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D004947:Esophagus / Q000187:drug effects / Q000473:pathology; D008297:Male; D009602:Nitrosamines; D051381:Rats; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000970:Antineoplastic Agents; D002273:Carcinogens; D009602:Nitrosamines; C028099:N-nitrososarcosine ethyl ester; D014810:Vitamin E; D024502:alpha-Tocopherol; D001205:Ascorbic Acid; D024505:Tocopherols
Vliianie tokoferola i askorbinovoĭ kisloty na razvitie éksperimental'nykh opukholeĭ pishchevoda.