[The effect of T-lymphocytes on epithelial proliferation of the jejunal mucosa in thymectomized mice].
Following 1.5 month period after thymectomy of adult mice the crypt 3H-thymidine labelling index is decreased and the proliferative zone is reduced. Analysis of labeled cell distributions in the crypt revealed that thymectomy resulted in the initiation of enterocyte entering a maturation phase in the site shifted to the crypt base. Syngeneic T-lymphocytes injected intravenously to thymectomized mice increased the labeling index, but exerted no effect on the size of proliferative zone. The proliferative changes described were not due to changes in the number of divisions of rapidly proliferating enterocytes. The role of T-lymphocytes in modulation of intestinal epithelium proliferation and steady state maintenance is discussed.
Shmakov
A N
AN
Trufakin
V A
VA
D000818:Animals; D001345:Autoradiography; D002455:Cell Division / Q000276:immunology; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D007413:Intestinal Mucosa / Q000166:cytology* / Q000276:immunology; D007583:Jejunum / Q000166:cytology* / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology / Q000637:transplantation; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D013934:Thymectomy; D013936:Thymidine; D013950:Thymus Gland / Q000502:physiology*; D014185:Transplantation, Isogeneic; D014316:Tritium
D014316:Tritium; D013936:Thymidine
Vliianie T-limfotsitov na proliferatsiiu épiteliia slizistoĭ obolochki toshcheĭ kishki u timéktomirovannykh mysheĭ.