title: EEG alpha photic driving abnormalities in chronic schizophrenia.
abstract: Periodic photic stimuli across the entire electroencephalographic (EEG) frequency range were used in an attempt to assess EEG functional differences between chronic schizophrenic patients and control subjects. The EEG responses to these photic stimuli were significantly attenuated in the schizophrenic patients, specifically at the frequencies within the EEG alpha range. The schizophrenic patients also showed an alpha range attenuation in the "no stimulus" EEG alpha measure, such that there was a significant correlation across subjects between the "stimulus" and "no stimulus" EEG alpha range abnormalities. These abnormalities are discussed with reference to possible dysfunctional thalamic mechanisms involved in the pacing of EEG alpha activity and the gating of information through the cerebral cortex.
authors.affiliation: Brain Imaging Center, University of California-Irvine, College of Medicine 92717.
authors.forename: D M
authors.initials: DM
authors.lastname: Rice
authors.forename: S G
authors.initials: SG
authors.lastname: Potkin
authors.forename: Y
authors.initials: Y
authors.lastname: Jin
authors.forename: R
authors.initials: R
authors.lastname: Isenhart
authors.forename: C W
authors.initials: CW
authors.lastname: Heh
authors.forename: J
authors.initials: J
authors.lastname: Sramek
authors.forename: J
authors.initials: J
authors.lastname: Costa
authors.forename: C A
authors.initials: CA
authors.lastname: Sandman
mesh_terms: D000328:Adult; D000513:Alpha Rhythm; D001143:Arousal / Q000502:physiology*; D002540:Cerebral Cortex / Q000503:physiopathology; D002908:Chronic Disease; D004569:Electroencephalography; D006801:Humans; D008297:Male; D010775:Photic Stimulation; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012815:Signal Processing, Computer-Assisted; D013787:Thalamic Nuclei / Q000503:physiopathology; D014796:Visual Perception / Q000502:physiology*