[Current trends in experimental peripheral nerve regeneration].
Large posttraumatic defects in the peripheral nervous system need to discover methods to solve the demand of nerve grafts. There is no definite answer now. The authors present a model for nervous regeneration studies. Experiments are performed in the Wistar rat. A venous isograft is used to bridge defects of various size in a divided rat sciatic nerve. The venous tube is a guide for axonal regeneration. In one series, the tube is filled with physiological saline and, in a second one, neonatal Schwann cells are injected in the venous isograft. Results recorded are a combination of quantitative methods: neurophysiology and morphometry. The injection of neonatal Schwann cells is able to stimulate nerve regeneration but not completely.
Lejeune
G
G
Foidart
M
M
Severyns
A M
AM
Delree
P
P
Lejeune
A
A
Clermont
D
D
Rocoux
G
G
D000818:Animals; D009416:Nerve Regeneration; D051381:Rats; D011919:Rats, Inbred Strains; D012583:Schwann Cells / Q000637:transplantation*; D012584:Sciatic Nerve / Q000502:physiology* / Q000601:surgery; D014680:Veins / Q000637:transplantation*
Nouvelles orientations en régénération nerveuse périphérique expérimentale.