Placental proteins 12 and 14 in pre-eclampsia.
The concentrations of circulating placental protein 12 (PP12) and placental protein 14 (PP14) were measured in 41 patients with pre-eclampsia and in 17 control subjects. The levels of PP12 were significantly elevated in patients with severe preeclampsia, whereas PP14 levels were unaffected. There was a negative correlation between the levels of both PP12 and PP14 and birthweight. PP12 and PP14 appear therefore to have different control mechanisms and, possibly, different cellular origins within the decidua.
Howell
R J
RJ
Department of Reproductive Physiology, St Bartholomew's Hospital Medical College, London, England.
Economides
D
D
Teisner
B
B
Farkas
A G
AG
Chard
T
T
D001724:Birth Weight; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins; D006801:Humans; D007231:Infant, Newborn; D018970:Insulin-Like Growth Factor Binding Protein 1; D018969:Insulin-Like Growth Factor Binding Proteins; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*
D000071816:Glycodelin; D006023:Glycoproteins; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D018969:Insulin-Like Growth Factor Binding Proteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins