[The myoelectrical activity of the gastroduodenal area in ulcer formation due to serotonin].
The effects of prolonged subcutaneous administration of serotonin on the myoelectric activity of the gastroduodenal junction were investigated in conscious rabbits. Serotonin produced the duodenogastric discoordination by increasing duodenal activity and decreasing the activity of stomach and pylorus. This discoordination resulted in gastric ulceration. Atropine prevented both duodenogastric discoordination and ulceration. These results indicate that serotonin ulceration is related to duodenogastric discoordination.
Shemerovskiĭ
K A
KA
D000818:Animals; D003404:Creatinine / Q000633:toxicity*; D004338:Drug Combinations / Q000633:toxicity; D004386:Duodenum / Q000187:drug effects / Q000503:physiopathology; D004576:Electromyography; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000503:physiopathology*; D010437:Peptic Ulcer / Q000139:chemically induced / Q000503:physiopathology*; D011817:Rabbits; D012701:Serotonin / Q000633:toxicity*; D013270:Stomach / Q000187:drug effects / Q000503:physiopathology
D004338:Drug Combinations; C014050:creatinine sulfate, serotonin drug combination; D012701:Serotonin; D003404:Creatinine
Mioélektricheskaia aktivnost' gastroduodenal'noĭ zony pri iazvoobrazovanii, vyzvannom serotoninom.