[The development and use of nitrate therapy].
The authors describe the development of nitrates from substances of the first generation (nitroglycerin and isosorbide dinitrate) to the use of mononitrates. They explain the mechanism of their action, the haemodynamic effects and the phenomenon of nitrate tolerance. The authors present also their own experience with nitrate therapy in angina pectoris and heart failure based on haemodynamic monitoring and recommend its rational use.
Stejfa
M
M
Vítovec
J
J
D055598:Chemical Phenomena; D002621:Chemistry; D006331:Heart Diseases / Q000188:drug therapy; D006801:Humans; D009566:Nitrates / Q000494:pharmacology / Q000627:therapeutic use*
D009566:Nitrates
Vývoj a uzití nitrátové terapie.