title: [Limits on the use of propylene glycol in topical preparations].
abstract: The authors define some limits for useful concentrations of propylene glycol (P.G.) by determination of inhibition produced in cell respiration from (crushed) mouse liver and in human cutaneous fibroblastic proliferation. They conclude that P.G. is able to inhibit both these physicological mechanisms from concentration as weak as 5.5% and 2% respectively. They give a method for analytical determination of P.G. in cosmetic and pharmaceutical products using gas liquid chromatography. This method is useful for a wide range of concentrations.
authors.forename: M F
authors.initials: MF
authors.lastname: Bobin
authors.forename: M L
authors.initials: ML
authors.lastname: Madarasz
authors.forename: M C
authors.initials: MC
authors.lastname: Martini
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002849:Chromatography, Gas; D005079:Excipients; D006801:Humans; D051379:Mice; D010101:Oxygen Consumption / Q000187:drug effects; D011409:Propylene Glycols / Q000008:administration & dosage / Q000032:analysis / Q000633:toxicity*
chemical_list: D005079:Excipients; D011409:Propylene Glycols
vernacular_title: Limites d'utilisation du propylène glycol dans les produits à usage topique.