Carbon monoxide excretion as an index of bilirubin production in rhesus monkeys.
The role of increased heme catabolism in neonatal hyperbilirubinemia was investigated in rhesus (Macaca mulatta) neonates through the measurement of carbon monoxide excretion rates (VECO), blood carboxyhemoglobin content (HbCO), and plasma bilirubin concentrations. Neonatal values were compared to those of adult rhesus monkeys. These indices of bilirubin production responded appropriately to administration of NEM-damaged erythrocytes and tin protoporphyrin. Our results indicate that VECO measurements are a valid index of changes in bilirubin production in the newborn rhesus monkey.
Vreman
H J
HJ
Department of Pediatrics, Stanford University School of Medicine, CA.
Rodgers
P A
PA
Gale
R
R
Stevenson
D K
DK
D000818:Animals; D000831:Animals, Newborn; D001663:Bilirubin / Q000097:blood*; D002248:Carbon Monoxide / Q000032:analysis*; D002263:Carboxyhemoglobin / Q000032:analysis; D004195:Disease Models, Animal; D006418:Heme / Q000378:metabolism; D006419:Heme Oxygenase (Decyclizing) / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006932:Hyperbilirubinemia / Q000209:etiology* / Q000628:therapy; D008251:Macaca; D008253:Macaca mulatta; D008665:Metalloporphyrins / Q000627:therapeutic use; D011524:Protoporphyrins / Q000627:therapeutic use
D006454:Hemoglobins; D008665:Metalloporphyrins; D011524:Protoporphyrins; D006418:Heme; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; C032628:tin protoporphyrin IX; D006419:Heme Oxygenase (Decyclizing); D001663:Bilirubin