title: Immediate versus delayed progesterone supplementation in gamete intrafallopian transfer (GIFT).
abstract: Exogenous progesterone (P) was supplemented to gamete intrafallopian transfer (GIFT) patients to determine the optimal timing to start P supplementation and the role of isthmic block in GIFT. Patients were alternatively divided into two groups. In the immediate group, exogenous P was supplied from the day of surgery. In the delayed group, P was supplied 4 days after the surgery, the day the fertilized ovum is supposed to arrive in the uterine cavity. Except for higher serum P levels on luteal day 3 in the immediate group, no significant differences were found in serum P levels during the early luteal phase, the pregnancy rate, and the abortion rate between the two groups. It is possible that in stimulated cycles, higher serum P levels during the early luteal phase render the endometrium receptive for embryo implantation, albeit unlock the isthmic block. It may not be crucial to start exogenous P supplementation either before or after a fertilized egg(s) arrives in the uterine cavity. The role of isthmic block in GIFT needs further evaluation.
authors.affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC.
authors.forename: S Y
authors.initials: SY
authors.lastname: Chang
authors.forename: Y K
authors.initials: YK
authors.lastname: Soong
authors.forename: M Y
authors.initials: MY
authors.lastname: Chang
authors.forename: D Y
authors.initials: DY
authors.lastname: Hsiu
mesh_terms: D005187:Fallopian Tubes / Q000502:physiology; D005260:Female; D015181:Gamete Intrafallopian Transfer / Q000379:methods*; D006801:Humans; D008183:Luteal Phase / Q000187:drug effects; D011374:Progesterone / Q000008:administration & dosage*
chemical_list: D011374:Progesterone