Focal irradiation of perforating eye injuries.
Plaques constructed with 125I were used to irradiate the sites of perforating ocular injuries in rabbits. An approximate dose of 16Gy given over a period of 6 days was shown to significantly reduce intraocular cellular proliferation when irradiation was commenced within 24 hours after injury. If irradiation was delayed until day 5, this reduction in cellular proliferation and intraocular membrane formation did not occur. Smaller radiation doses of approximately 6Gy given within 24 hours post-injury and administered over 6 days also reduced the extent of cellular proliferation but was not as effective as the 16Gy dose.
Chakravarthy
U
U
Department of Ophthalmology, Queen's University of Belfast, Royal Victoria Hospital, UK.
Biggart
J H
JH
Gardiner
T A
TA
Archer
D B
DB
Maguire
C J
CJ
D000818:Animals; D001918:Brachytherapy; D002455:Cell Division / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D015807:Eye Injuries, Penetrating / Q000532:radiotherapy*; D005720:Gamma Rays; D007457:Iodine Radioisotopes; D011817:Rabbits; D011897:Random Allocation; D012160:Retina / Q000473:pathology / Q000528:radiation effects; D012590:Sclera / Q000473:pathology / Q000528:radiation effects; D013997:Time Factors; D014822:Vitreous Body / Q000473:pathology / Q000528:radiation effects; D014945:Wound Healing / Q000528:radiation effects*
D007457:Iodine Radioisotopes