title: [Detection and determination of acetone using semiconductor sensors].
abstract: Investigations to examine not only the factors of influence on evaluation of acetone by self-prepared semiconductor gas sensors, but also to prove analytical properties, were carried out using different tools. A sensor temperature of 600 degrees C and a carrier gas flow-rate of 5 l/h were found to be suitable conditions for the measurement of flow-injection apparatus. The determination of 1 microliter-samples of aqueous solutions containing 1-700 g of acetone/l yielded deviations of 4 to 33%. Using a head space method, the working temperature of 370 degrees C led to a maximum sensor response, the detection limit ranged from 37.5 to 50 mg of acetone/l. After quantifying 5 microliters-sample solutions of 40-600 mg/l, results with an accuracy of 1 to 36% were obtained. The method showed the possibility of distinguishing concentrations of acetone below and above 40 mg/l according to physiological and pathological urinary values. The tests carried out on 100 human urine samples provide a good agreement with the Legal reference method for samples containing physiological or strong pathological amounts of ketone bodies, but not for those including traces and small amounts. False-positive results might be caused by a possible presence of ethanol in urine.
authors.affiliation: Sektionen Pharmazie, Ernst-Moritz-Arndt-Universität Greifswald.
authors.forename: J
authors.initials: J
authors.lastname: Reichel
authors.forename: T
authors.initials: T
authors.lastname: Seyffarth
authors.forename: U
authors.initials: U
authors.lastname: Guth
authors.forename: H H
authors.initials: HH
authors.lastname: Möbius
authors.forename: D
authors.initials: D
authors.lastname: Göckeritz
mesh_terms: D000096:Acetone / Q000032:analysis* / Q000652:urine; D006801:Humans; D012666:Semiconductors; D013696:Temperature
chemical_list: D000096:Acetone
vernacular_title: Untersuchungen zum Nachweis und zur Bestimmung von Aceton mit Halbleitersensoren.