[The effect of pyridoxine on the cerebral hemodynamics in vestibular disorders].
By means of hydrogen clearance on conscious rabbits with implanted platinum electrodes it was established that pyridoxine (1 and 10 mg/kg) used against the background of sea sickness decreased the dilatational reaction of the cerebral vessels occurring during the stimulation of the vestibular apparatus, reduced the blood supply to the cerebral hemispheres with insignificant changes of oxygen tension in the cortical structures, relieved acidosis and hypoxemia developing during sickness in the orthostatic position, increased oxygenation of the arterial blood without influencing significantly pathomorphological shifts in the brain tissue.
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D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004567:Electrodes, Implanted; D005260:Female; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D008297:Male; D009041:Motion Sickness / Q000188:drug therapy / Q000503:physiopathology; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D010313:Partial Pressure; D011736:Pyridoxine / Q000627:therapeutic use*; D011817:Rabbits; D013997:Time Factors; D015837:Vestibular Diseases / Q000188:drug therapy* / Q000503:physiopathology
D011736:Pyridoxine
Vliianie piridoksina na tserebral'nuiu gemodinamiku pri vestibuliarnykh rasstroĭstvakh.