Pharmacologic evaluation of cardiovascular reflex responses in migraine patients: lack of central sympathetic modulation?
To characterize autonomic imbalance in migraine, we compared the cardiovascular reflex responses of 10 migraineurs and 10 healthy subjects after pharmacological noradrenergic stimulation or inhibition. A battery of 5 autonomic tests was administered on basal conditions as well as after pretreatment with drugs acting at different levels on the noradrenergic pathway: pseudoephedrine, clonidine, guanethidine, indenolol, prazosin. Our data confirm a predominantly sympathetic hypofunction in migraine and provide evidence for an impairment of the central autonomic control.
Munari
L
L
Neurologic Institute C. Besta, Milan, Italy.
Milanesi
I
I
Silvani
A
A
Bussone
G
G
Boiardi
A
A
D000328:Adult; D002319:Cardiovascular System / Q000503:physiopathology*; D002490:Central Nervous System / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*