Protective immunity against Angiostrongylus cantonensis in rats following sensitizing infections.
Three strains (ACI, August and Wistar) of rats previously sensitized by oral infection with intact third-stage larvae of Angiostrongylus cantonensis developed significant protective immunity to challenge infections 6 weeks later. The degree of the immunity was highest in the August strain of rats, followed by Wistar and ACI rats. Protective immunity appears to affect both third-stage larvae and fourth- and/or fifth-stage worms. ACI rats showed poor antibody responses, especially in the IgE fraction. When 24-day-old young adult worms were transferred from the brain of donor rats into the peritoneal cavity of sensitized rodents, peritoneal eosinophils predominantly adhered to the worm surfaces in vivo.
Yoshimura
K
K
Department of Parasitology, Akita University School of Medicine, Japan.
Ishida
K
K
Ishigooka
S
S
Sugaya
H
H
Kumagai
M
M
D000801:Angiostrongylus / Q000276:immunology; D000818:Animals; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D007814:Larva / Q000276:immunology; D008297:Male; D009349:Nematode Infections / Q000276:immunology* / Q000517:prevention & control; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats; D011912:Rats, Inbred ACI; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains