title: IgG2/IgG4 subclass deficiency in a patient with chronic mucocutaneous candidiasis and bronchiectases.
abstract: A 22-year-old man with chronic mucocutaneous candidiasis (CMC) and hypothyroidism developed severe bronchiectases following recurrent bronchopneumonia. Immunological investigations revealed IgG2/IgG4 subclass deficiency and absence of antibodies against pneumococcal and Haemophilus polysaccharides. Under regular immunoglobulin substitution every 3 weeks pulmonary symptoms improved markedly.
authors.affiliation: Department of Paediatrics, University of Zurich, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Brägger
authors.forename: R A
authors.initials: RA
authors.lastname: Seger
authors.forename: R
authors.initials: R
authors.lastname: Aeppli
authors.forename: F
authors.initials: F
authors.lastname: Hallè
authors.forename: W H
authors.initials: WH
authors.lastname: Hitzig
mesh_terms: D000328:Adult; D001987:Bronchiectasis / Q000209:etiology*; D002177:Candidiasis / Q000209:etiology*; D002178:Candidiasis, Chronic Mucocutaneous / Q000150:complications / Q000209:etiology* / Q000276:immunology; D004406:Dysgammaglobulinemia / Q000097:blood / Q000150:complications*; D006801:Humans; D017099:IgG Deficiency; D007074:Immunoglobulin G / Q000145:classification; D008297:Male
chemical_list: D007074:Immunoglobulin G