Adhesion induced by mobile cross-bridges: steady state peeling of conjugated cell pairs.
Recent experiments on cell-cell adhesion indicate that (i) bonds between two cells migrate towards the region of conjugation during peeling, and (ii) cell membrane tension increases with the rate of peeling. Analytical methods that would allow the derivation of intrinsic parameters of adhesion from such experimental data have yet to be explored. In this study we introduce a specific adhesion model to investigate the complex interaction between rate of peeling, lateral diffusivity and the rate of detachment of bonds. Our analysis show that adhesive energy density increases with the rate of peeling and with lateral diffusivity of the bonds but decreases with increasing rate of detachment. The rate dependency of the adhesive energy is due to the modulation of the number density distribution of bonds by the speed of peeling.
Tozeren
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Department of Mechanical Engineering, Catholic University of America, Washington DC 20064.
D055592:Biophysical Phenomena; D001703:Biophysics; D002448:Cell Adhesion; D002462:Cell Membrane / Q000502:physiology; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D013601:T-Lymphocytes / Q000502:physiology