Effect of inhalation of insecticide spray on learning and memory in rats.
Acute exposure to insecticide (Baygon-spray; 5 ml/animal/5 min) inhalation in rats did not affect the learning process but produced a significant loss of memory (P less than 0.01 less than 0.001) whereas chronic exposure (one exposure per day for three weeks) produced a significant delay in learning (P less than 0.05) and memory (P less than 0.01). Acetylcholinesterase activity in brain after acute and chronic exposure declined significantly (P less than 0.01) during the learning process but returned to normal after 24 hr.
Mathew
R
R
Verghese
J
J
Venkataraman
B V
BV
Joseph
T
T
D000110:Acetylcholinesterase / Q000032:analysis; D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D001921:Brain / Q000201:enzymology; D005260:Female; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000336:Aerosols; D007306:Insecticides; D000110:Acetylcholinesterase