title: Vitamin E, selenium, and polyunsaturated fatty acid concentrations and glutathione peroxidase activity in tissues from pigs with dietetic microangiopathy (mulberry heart disease).
abstract: Tissues of 27 pigs with spontaneous dietetic microangiopathy (DM) and of 27 control pigs that died of causes unrelated to vitamin E and selenium (E-Se) deficiency were analyzed for alpha-tocopherol, Se and polyunsaturated fatty acid (PUFA) concentrations and for glutathione perioxidase (GSH-Px) activity. These variables (except for GSH-Px) also were measured in rations fed to control pigs and pigs with DM. Swine with DM had lower heart and liver alpha-tocopherol concentrations than did control pigs. Heart and kidney Se concentrations and heart and liver PUFA concentrations were similar in pigs of either group. Diets fed to both groups of pigs contained similar content of alpha-tocopherol, Se, oil, and PUFA; alpha-tocopherol and Se concentrations in the diets of both groups of pigs were high. In spite of apparently adequate amount of dietary alpha-tocopherol, results indicate that pigs with DM had lower tissue alpha-tocopherol concentration than did control pigs. Spontaneous DM is associated with altered alpha-tocopherol metabolism, but is unrelated to alterations in dietary Se and PUFA contents and tissue Se and PUFA concentrations and GSH-Px activity.
authors.affiliation: Department of Biochemistry, Veterinary Research Laboratories, Stormont, Belfast, Northern Ireland.
authors.forename: D A
authors.initials: DA
authors.lastname: Rice
authors.forename: S
authors.initials: S
authors.lastname: Kennedy
mesh_terms: D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000032:analysis*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006331:Heart Diseases / Q000201:enzymology / Q000378:metabolism / Q000662:veterinary*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008833:Microcirculation; D009206:Myocardium / Q000201:enzymology*; D012643:Selenium / Q000032:analysis*; D013552:Swine / Q000378:metabolism; D013553:Swine Diseases / Q000201:enzymology / Q000378:metabolism*; D014810:Vitamin E / Q000032:analysis*
chemical_list: D005231:Fatty Acids, Unsaturated; D014810:Vitamin E; D005979:Glutathione Peroxidase; D012643:Selenium