Influence of selection for increased body weight on the incidence of leiomyomas and leiomyosarcomas in Japanese quail.
Leiomyomas and leiomyosarcomas were observed in adult laying hens from lines of Japanese quail selected solely (HW) or partly (HW-HP; HW-LP) for increased 4-wk BW and the corresponding randombred control (R1). No neoplasms were observed in a line (LW) selected for decreased 4-wk BW based on observations in one generation. Line R1 served as the base population for Lines HW and LW and was maintained without conscious selection for any trait, Lines HW-HP and HW-LP were sublines of Line HW in which the males were selected for increased 4-wk BW and the females were selected for high or low levels of plasma total phosphorus, respectively. Hens of all lines were necropsied after completing a 120-day production period. A high incidence of neoplasms were found in the dorsal and ventral ligaments of the oviduct in the immediate vicinity of the magnum, and the incidence was much greater in the lines selected for increased growth than in Line R1. These results suggest that selection for increased BW in Lines HW, HW-HP, and HW-LP has resulted in genetic changes that are conducive to neoplastic growth. Based on the results of one generation, it appears that selection for decreased 4-wk BW reduced incidence of neoplasms.
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Department of Poultry Science, Ohio State University, Wooster 44691.
Nestor
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Saif
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Bacon
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Moorhead
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D000818:Animals; D001835:Body Weight / Q000235:genetics; D001947:Breeding; D003370:Coturnix; D005260:Female; D005833:Genital Neoplasms, Female / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D015994:Incidence; D007889:Leiomyoma / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D007890:Leiomyosarcoma / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D010057:Oviducts; D010058:Oviposition; D011201:Poultry Diseases / Q000453:epidemiology* / Q000235:genetics; D011784:Quail