Inhibition by sodium bromide of synaptic potentiation and calcium accumulation in the superior cervical ganglion of rat.
Electrophysiological data show that sodium bromide (NaBr) inhibits the development of the post-tetanic potentiation in superior cervical ganglia of rat. NaBr treatment also prevented the accumulation of calcium in synaptic vesicles and dendritic vacuoles otherwise seen for some minutes after a tetanizing stimulation. These observations support the notion that the calcium ions entering into pre- and postsynaptic elements play an important role in the genesis of synaptic potentiation.
Párducz
A
A
Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Center, Szeged, Hungary.
Toldi
J
J
Joó
F
F
Wolff
J R
JR
D000818:Animals; D001965:Bromides / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005728:Ganglia, Sympathetic / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000494:pharmacology*; D017670:Sodium Compounds; D013569:Synapses / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure
D001965:Bromides; D017670:Sodium Compounds; D012964:Sodium; C027938:sodium bromide; D002118:Calcium