Effect of subacute low level dietary sodium arsenite on dogs.
Thirty female beagle dogs, 7 to 8 months old, were assigned to five groups. Control, low dosage, medium dosage, high dosage, and pair-fed groups were offered 0, 1, 2, 4 and 0 mg of sodium arsenite per killigram of body weight per day (mg/kg/day), respectively, in their feed. On Day 59, the dosage was doubled for the rest of the experiment, which ended on Day 183. Nominal dosages of 4 and 8 mg/kg/day caused a significant decrease in feed consumption. The initial decreased feed consumption was followed by increased intake over time. Nominal dosages of 4 and 8 mg/kg/day caused a significant decrease in body weight. Body weight loss of high dosage and pair fed groups were not significantly different. Serum aspartate aminotransferase was elevated in dogs exposed to 4 and 8 mg/kg/day of sodium arsenite. Serum alanine aminotransferase was elevated in dogs exposed to 2, 4, and 8 mg/kg/day. No gross or light microscopic lesions were present in the liver of any group. This study shows that dietary sodium arsenite causes a dose-dependent decrease of feed consumption and body weight. Weight loss is caused by decreased feed consumption, not by the direct effect of the sodium arsenite.
Neiger
R D
RD
College of Veterinary Medicine, Iowa State University, Ames 50011.
Osweiler
G D
GD
D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D018053:Arsenites; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001777:Blood Coagulation / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004285:Dogs; D004435:Eating / Q000187:drug effects; D004798:Enzymes / Q000097:blood; D005260:Female; D008099:Liver / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D017670:Sodium Compounds
D018053:Arsenites; D004798:Enzymes; D017670:Sodium Compounds; C017947:sodium arsenite; D001151:Arsenic