[Fluidity of erythrocyte membranes in patients with ischemic cerebral vascular disease].
Measurement of fluidity of erythrocyte membrane (FEM) in thirty-six patients with ischemic cerebral vascular disease (ICVD) by fluorescence polarization of DPH (1,6,-Diphenyl-1,3,5-hexatriene) labelled on lipo-region in intact erythrocyte membrane. Twenty one healthy subjects without any stagnation of blood as control. Also research on coefficient of multiple correlation among the FEM and other factors in whole blood or plasma by using stepwise multi-regression analysis. The results revealed that: (1) FEM of patients with ICVD was 3.55 +/- 0.21 (eta), which was significantly higher than that of healthy subjects (2.77 +/- 0.12 eta), P less than 0.001. (2) The FEM of patients with ICVD were positive correlation with RBC electrophoresis rate, whole blood viscosity and low density lipo-proteins and were negative correlation with high density lipo-proteins. These findings suggested that it would be available for preventing ICVD by increasing of the surface charge on erythrocyte and of the high density lipo-proteins.
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D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000097:blood*; D004910:Erythrocyte Membrane; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood*; D008297:Male; D008560:Membrane Fluidity; D008875:Middle Aged