Blood concentrations after accidental cyclosporin overdose.
Two cases of children are reported with an accidental oral overdose of cyclosporin in whom blood concentrations were monitored. Despite a tenfold oral overdose, the peak blood concentrations of cyclosporin in both patients were only moderately increased above therapeutic levels. Apart from a transient rise in blood pressure in one patient, no toxic effects of cyclosporin were noticed.
de Meer
K
K
Department of Paediatrics, University Hospital Groningen, The Netherlands.
Houwen
R H
RH
Bijleveld
C M
CM
Uges
D R
DR
Slooff
M J
MJ
D001682:Biological Availability; D002675:Child, Preschool; D003524:Cyclosporins / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008103:Liver Cirrhosis / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D016031:Liver Transplantation; D008297:Male
D003524:Cyclosporins