Congenital factor XIII deficiency with multiple benign breast tumours and successful pregnancy with substitutive therapy. A case report.
A 34-year-old woman with congenital factor XIII (FXIII) deficiency and multiple connective tissue tumours is reported. The subunit a of FXIII was totally absent in her plasma, platelets and histiocytes of breast fibroadenomas and considerably reduced in the monocytes (below 5%). The plasmatic level of subunit b was also reduced (25%). She had a bleeding tendency and habitual abortions. Fresh frozen plasma therapy permitted a successful pregnancy.
Boda
Z
Z
Second Department of Medicine, University Medical School, Debrecen, Hungary.
Pfliegler
G
G
Muszbek
L
L
Tóth
A
A
Adány
R
R
Hársfalvi
J
J
Papp
Z
Z
Tornai
I
I
Rak
K
K
D000328:Adult; D001943:Breast Neoplasms / Q000150:complications* / Q000628:therapy; D005260:Female; D006467:Hemophilia A / Q000150:complications* / Q000628:therapy; D006801:Humans; D010949:Plasma; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011252:Pregnancy Complications, Neoplastic