Octadeca-9,11-dienoic acid in cervical intraepithelial neoplasia: a colposcopic study.
488 women were studied to evaluate the use of the molar ratio (%MR) of octadeca-9,11-dienoic acid (18:2(9, 11] to linoleic acid (18:2(9, 12] as a new screening method for cervical cancer and pre-cancer. A combination of Papanicolaou cytology, colposcopy and %MR 18:2(9, 11)/18:2(9, 12) were employed. 86 women (17.6%) were found to have histologically proven cervical intraepithelial neoplasia (CIN). The %MR was obtained in 452 cases (92%). There was no significant difference in %MR in cervical cell scrapes from women with or without CIN. The %MR of cervical scrapes in some women with anaerobic vaginosis was significantly elevated suggesting bacterial generation of 18:2(9, 11). The %MR of 18:2(9, 11)/18:2(9, 12) is unsuitable for the diagnosis of cervical intraepithelial neoplasia.
Fairbank
J
J
Department of Chemical Pathology, Whittington Hospital, London, UK.
Hollingworth
A
A
Griffin
J
J
Ridgway
E
E
Wickens
D
D
Singer
A
A
Dormandy
T
T
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002278:Carcinoma in Situ / Q000175:diagnosis*; D002851:Chromatography, High Pressure Liquid; D003127:Colposcopy; D005260:Female; D006801:Humans; D007536:Isomerism; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000032:analysis*; D011230:Precancerous Conditions / Q000175:diagnosis*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D008041:Linoleic Acids; D019787:Linoleic Acid