Effect of acute bromopride treatment on rat prolactin levels and sexual behavior.
Acute intraperitoneal administration of bromopride (BRO), a dopamine D2 blocker used as an anti-emetic drug in gastroenterology was tested in male and female rats for its effect on prolactin (PRL) serum levels and on sexual behavior. Rats that received 2.5 mg/kg BRO, the lowest dose tested, showed a maximal increase in PRL serum levels. Male rats that received 5.0 mg/kg BRO showed higher postejaculatory mount latency and postejaculatory intromission latency than controls. Rats treated with 10.0 mg/kg BRO showed higher mount latency, intromission latency, ejaculation latency, postejaculatory mount latency and a lower percentage of animals showing mount and ejaculation. Female rats that received 5.0 mg/kg BRO showed a lower lordosis quotient. The data suggest that blockade of postsynaptic dopamine D2 receptors inhibits male and female sexual behavior and that this inhibition is not related solely to the increase in PRL levels.
Felício
L F
LF
Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Brasil.
Nasello
A G
AG
D000818:Animals; D003307:Copulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008787:Metoclopramide / Q000031:analogs & derivatives* / Q000494:pharmacology; D011187:Posture; D011388:Prolactin / Q000097:blood*; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*
C013855:bromopride; D011388:Prolactin; D008787:Metoclopramide