Treatment of Lyme borreliosis. Randomized comparison of doxycycline and penicillin G.
Seventy-five patients with neurological symptoms of Lyme borreliosis were randomly assigned to intravenous treatment with either penicillin G or doxycycline. After 12 months the treatments were equally effective regarding the clinical picture and laboratory findings. No patient was considered to be a treatment failure. However, one-third of the patients showed delayed recovery, particularly after a longer primary disease duration. A slow recovery, lasting years, was typical of subacute or chronic borreliosis.
Kohlhepp
W
W
Department of Neurology, University of Würzburg, Federal Republic of Germany.
Oschmann
P
P
Mertens
H G
HG
D000328:Adult; D000368:Aged; D004318:Doxycycline / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008193:Lyme Disease / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D010400:Penicillin G / Q000627:therapeutic use*; D011897:Random Allocation
D007166:Immunosuppressive Agents; D004318:Doxycycline; D010400:Penicillin G