title: [Disseminated intravascular coagulation and acute hepatic necrosis at the end of pregnancy. A case report].
abstract: A 30-year-old woman in the 36th week of her second pregnancy, suddenly developed jaundice with remarkable liver necrosis, accompanied by generalized bleeding due to disseminated intravascular coagulation (DIC). She underwent a caesarean and a dead foetus was extracted from the uterus. Heparin and frozen plasma infusion resulted in a prompt recovery from the haemostatic disorder. The course of the disease involved the successive appearance of haemorrhagic shock, intestinal ileus and pulmonary embolism all of which she recovered from. The liver biopsy showed severe cholestasis without derangement of the lobular structure. Hypotheses of acute veno-occlusive disease caused by the DIC, and acute fatty liver of pregnancy are discussed.
authors.affiliation: Università di Sassari, Clinica Medica Generale.
authors.forename: L A
authors.initials: LA
authors.lastname: Sechi
authors.forename: A
authors.initials: A
authors.lastname: Marigliano
authors.forename: A
authors.initials: A
authors.lastname: Melis
authors.forename: R
authors.initials: R
authors.lastname: Tedde
mesh_terms: D000208:Acute Disease; D000328:Adult; D001706:Biopsy; D002585:Cesarean Section; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005313:Fetal Death / Q000209:etiology / Q000473:pathology; D006801:Humans; D007565:Jaundice / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D008099:Liver / Q000473:pathology*; D009336:Necrosis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D011263:Pregnancy Trimester, Third
vernacular_title: Coagulazione intravascolare disseminata e necrosi epatica acuta a termine di gravidanza. Descrizione di un caso.