title: Scanning electron microscopic study of the middle ear mucosa after transtympanic infusion of fluids with different osmotic pressure.
abstract: This study focused on the morphological alteration of the mucous membrane of the middle ear after transtympanic infusion of fluids with different osmotic pressure. Our results suggested that fluids with high osmotic pressure will seriously damage the mucous membrane of the middle ear regardless of whether or not the fluids have ototoxicity. On the other hand, fluids with low osmotic pressure were found to demonstrate minor changes on the mucous membrane. The authors have confirmed through this study that Beriplast-P A (894 mOsm) and B (228 mOsm), fibrinogen-based tissue sealants, may be safely used in the middle ear with minimum injury to the mucous membrane.
authors.affiliation: Department of Otorhinolaryngology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: E
authors.initials: E
authors.lastname: Ishiyama
authors.forename: H
authors.initials: H
authors.lastname: Tomita
mesh_terms: D000818:Animals; D001469:Barotrauma / Q000209:etiology*; D002923:Cilia / Q000648:ultrastructure; D004432:Ear, Middle / Q000293:injuries* / Q000648:ultrastructure; D006168:Guinea Pigs; D008855:Microscopy, Electron, Scanning; D008871:Microvilli / Q000648:ultrastructure; D009092:Mucous Membrane / Q000293:injuries / Q000648:ultrastructure; D009997:Osmotic Pressure; D012996:Solutions / Q000009:adverse effects*
chemical_list: D012996:Solutions