title: Hemorheology in systemic ultrahigh-dose thrombolytic therapy with streptokinase and urokinase.
abstract: The course of fibrinogen (Fgen), red cell aggregation (RCA), plasma viscocity (PV), platelet aggregation (PA) and hematocrit (Hc) was studied in patients with ultrahigh - dose thrombolytic therapy (1.5 x 10(6) units/hour for 6 hours = 1 cycle) with streptokinase (SK) or urokinase (UK) over a period of 3 cycles. Both ultrahigh - dose SK and UK produced significant changes in the course of Fgen, RCA and PV, whereas PA (spontaneous and ADP-induced) and Hc remained unchanged. After termination of each cycle Fgen progressively increased while RCA and PV further decreased. The extent of alteration in cycle 1 - concerning the baseline values - was more pronounced with SK than with UK, but the overall effect of SK decreased through the consecutive cycles because of more rapid increase during the SK-free period. In UK-therapy hemorheological alterations were initially moderate but increased from cycle to cycle.
authors.affiliation: 1st Department of Medicine, University of Vienna, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Koppensteiner
authors.forename: M
authors.initials: M
authors.lastname: Jung
authors.forename: E
authors.initials: E
authors.lastname: Minar
authors.forename: H
authors.initials: H
authors.lastname: Ehringer
mesh_terms: D000328:Adult; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000188:drug therapy*; D001809:Blood Viscosity / Q000187:drug effects; D004903:Erythrocyte Aggregation / Q000187:drug effects; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D012212:Rheology; D013300:Streptokinase / Q000008:administration & dosage*; D015912:Thrombolytic Therapy; D013924:Thrombophlebitis / Q000097:blood / Q000188:drug therapy*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D005340:Fibrinogen; D013300:Streptokinase; D014568:Urokinase-Type Plasminogen Activator