Characteristic of marrow culture and clinical relevance in leukemia with 8/21 translocation.
Karyotypes and in vitro cultures of bone marrow cells from eleven patients with acute myelogenous leukemia M2 type were performed. 8/21 translocation was found in 5 patients. In all of them the cultures in vitro shared one characteristic, i.e., clusters were small and less in number. These patients could relatively easily obtain complete remission. The similarity of CFU-GM in patients with t (8; 21) may be another important biological phenotype.
Sun
G X
GX
Wang
B M
BM
Yang
A D
AD
Yu
D J
DJ
D000293:Adolescent; D000328:Adult; D001853:Bone Marrow / Q000473:pathology*; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured