title: [Antifertility effects of RU-486 in combination with anordrin in rats].
abstract: RU-486 and anordrin suspended or dissolved in tea seed oil, alone or in combination, were given orally to rats on d 6-8 or d 11-13 of pregnancy, respectively. Complete interruption of early pregnancy was obtained after RU-486 at 8 mg/kg alone or 2.5 mg/kg combined with anordrin 2 mg/kg when given on d 6-8 of pregnancy. A complete mid-trimester abortion was obtained after RU-486 10 mg/kg alone or 4 mg/kg combined with anordrin 3 mg/kg when given on d 11-13 of pregnancy. Results obtained from the endometrial transformation test, the uteri cytoplasmic progesterone receptor estimation in immature rabbits, the deciduoma-inhibited test in pseudopregnant rats and the serum progesterone level in pregnant rats showed that RU-486 in combination with anordrin did not possess progestational, but rather marked antiprogestational activities. Since anordrin is relatively easy to obtain in China, RU-486 combined with anordrin may be ready to be used clinically as an effective oral antifertility agent.
authors.forename: P J
authors.initials: PJ
authors.lastname: Shen
authors.forename: Y X
authors.initials: YX
authors.lastname: Qian
authors.forename: R Y
authors.initials: RY
authors.lastname: Xu
authors.forename: Q C
authors.initials: QC
authors.lastname: Shen
authors.forename: G M
authors.initials: GM
authors.lastname: Liu
authors.forename: Z M
authors.initials: ZM
authors.lastname: Lin
mesh_terms: D000021:Abortifacient Agents, Steroidal; D000028:Abortion, Induced / Q000662:veterinary; D000818:Animals; D003281:Contraceptives, Postcoital; D003656:Decidua / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D015735:Mifepristone / Q000494:pharmacology*; D009635:Norandrostanes / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011555:Pseudopregnancy; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000021:Abortifacient Agents, Steroidal; D003281:Contraceptives, Postcoital; D009635:Norandrostanes; D015735:Mifepristone; D011374:Progesterone; C010855:anordrin