Donor-specific transfusion via the portal venous route induces prolongation of H-2-compatible but not H-2-incompatible cardiac graft survival.
In the H-2-compatible donor-recipient combination (BALB/c----DBA/2), pretransplant donor-specific blood transfusion (DST) via the portal venous (PV) route significantly prolonged cardiac graft survival. DST via the intravenous (IV) route (systemic circulation) also showed a marked prolongation of heart tissue transplant survival in this model. In the H-2-incompatible combination (BALB/c----CBA/H), DST via the IV - but not via the PV - route resulted in accelerated graft rejection.
Górecki
D
D
Department of Histology and Embryology, Institute of Biostructure, Medical School, Warsaw, Poland.
Jakóbisiak
M
M
Lupińska
M
M
Kruszewski
A
A
Czyźyk
J
J
D000818:Animals; D001803:Blood Transfusion / Q000379:methods; D006082:Graft Enhancement, Immunologic / Q000379:methods*; D006085:Graft Survival; D006183:H-2 Antigens; D016027:Heart Transplantation / Q000276:immunology*; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011169:Portal Vein; D014184:Transplantation, Homologous
D006183:H-2 Antigens