title: Acute gastric mucosal lesions, haemodynamic and microcirculatory changes in the thermally injured rat.
abstract: Early postburn changes in central haemodynamics, organ blood flow distribution and morphology of the gastric mucosa were studied using a standarized thermal skin injury model. Organ blood flow and cardiac output were determined using radioactive microspheres. In the control animals no marked changes in cardiac output or organ blood flow were observed, and the gastric mucosa remained essentially undamaged. After burn injury and no fluid resuscitation, cardiac output decreased by 78 per cent, and blood flow to the stomach, pancreas, spleen, muscle, skin and kidneys also decreased markedly and to about the same degree as the cardiac output, however the adrenal flow remained roughly unchanged at the baseline level. Gross and microscopic lesions developed in the stomach, especially in the corpus. In animals given fluid resuscitation after burn injury cardiac output decreased by 38 per cent during the experiment, but blood flow in the stomach, brain, kidneys and spleen remained fairly constant, while pancreatic and muscle blood flow decreased and adrenal blood flow increased markedly. The gastric mucosa showed only minor microscopic, but no macroscopic lesions at the end of the experiment. The results indicate that acute thermal skin injury induces profound changes in central haemodynamics and organ blood flow which can, however, largely be overcome by adequate fluid resuscitation. The data also suggest that, as in other examples of 'stress ulceration', impaired mucosal blood flow may underlie the stress ulceration which complicates severe burns.
authors.affiliation: 2nd Department of Surgery, Helsinki University Central Hospital, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Kiviluoto
authors.forename: J E
authors.initials: JE
authors.lastname: Grönbech
authors.forename: E
authors.initials: E
authors.lastname: Kivilaakso
authors.forename: T
authors.initials: T
authors.lastname: Lund
authors.forename: J
authors.initials: J
authors.lastname: Pitkänen
authors.forename: K
authors.initials: K
authors.lastname: Svanes
mesh_terms: D000208:Acute Disease; D000818:Animals; D002056:Burns / Q000503:physiopathology* / Q000628:therapy; D005440:Fluid Therapy; D005753:Gastric Mucosa / Q000473:pathology*; D006439:Hemodynamics; D008297:Male; D008833:Microcirculation; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000098:blood supply*