Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase.
An anti-HIV (human immunodeficiency virus) phenolic constituent, licopyranocoumarin (4), and two other new phenolics named licoarylcoumarin (5) and glisoflavone (6) were isolated from Si-pei licorice (a commercial licorice; root and stolon of Glycyrrhiza sp. from the north-western region of China) using droplet countercurrent chromatography and centrifugal partition chromatography, and their structures were assigned based on chemical and spectroscopic data. Kaempferol 3-O-methyl ether (7) and licocoumarone (8) were also isolated from the licorice. The inhibitory effects of ten licorice phenolics on xanthine oxidase were examined. Licochalcone B (1), glycyrrhisoflavone (2), 8 and licochalcone A (19) showed 50% inhibition at the concentration of 1.3-5.6 x 10(-5) M.
Hatano
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Yasuhara
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Fukuda
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Noro
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Okuda
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D003374:Coumarins / Q000494:pharmacology*; D006035:Glycyrrhiza / Q000032:analysis*; D010636:Phenols / Q000494:pharmacology*; D010946:Plants, Medicinal; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
D003374:Coumarins; D010636:Phenols; C063348:licopyranocoumarin; C063349:glisoflavone; D014969:Xanthine Oxidase