Evidence that alpha-tocopherol functions cyclically to quench free radicals in hepatic microsomes. Requirement for glutathione and a heat-labile factor.
McCay
P B
PB
Oklahoma Medical Research Foundation, Oklahoma City 73121.
Brueggemann
G
G
Lai
E K
EK
Powell
S R
SR
D000818:Animals; D002251:Carbon Tetrachloride / Q000031:analogs & derivatives / Q000378:metabolism; D005609:Free Radicals; D005978:Glutathione / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000008:administration & dosage / Q000502:physiology*
D005609:Free Radicals; D008563:Membrane Lipids; D014810:Vitamin E; C025280:trichloromethyl free radical; D002251:Carbon Tetrachloride; D005978:Glutathione