[Biotransformation of pyridazines. 1. Pyridazine and 3-methylpyridazine].
Pyridazin (1) and 3-methylpyridazine (6) undergo oxidative biotransformation in an unexpected high degree. Beside the unchanged compounds, after administration of 1 two isomeric monohydroxylated products (2, 3), 4,5-dihydrodihydroxypyridazine (4) and 4,5-dihydroxypyridazine (5) and after administration of 6 one ringhydroxylated 6-derivative (7), 3-hydroxymethylpyridazine (8), one ringhydroxylated 3-hydroxymethylpyridazine derivative (9) and 4,5-dihydroxy-3-methylpyridazine (10) were suggested as urinary metabolites in rats. 2 and 7 are the main metabolites of 1 and 6, respectively.
Borchert
H H
HH
Sektion Chemie, Wissenschaftsbereich Pharmazie, Humboldt-Universität zu Berlin.
Pfeifer
S
S
Helbig
B
B
Franke
P
P
Heinisch
G
G
D000818:Animals; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D008297:Male; D011724:Pyridazines / Q000378:metabolism* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
D011724:Pyridazines; C062483:3-methylpyridazine; C062482:pyridazine
Biotransformation von Pyridazinen. Teil 1: Pyridazin und 3-Methylpyridazin.