Study on some biologically active coordination compounds of metal ions (I)--Synthesis, characterization, structure and antitumor activity of complex of 3,6-di-(dimethylamino)-dibenzopyriodonium lanthanum EDTA.
The title coordination compound has been synthesized by the reaction of HLaEDTA.7H2O with (formula; see text) in ethanol aqueous solution. The single crystal has grown from aqueous solution and has been characterized by IR, TG-DTA, X-ray powder diffraction, molar conductance, UV and 1H-NMR. The determination of its crystal and molecular structure shows that it crystallizes in space group P21/n with lattice parameters: a = 14.735A, b = 29.335A, c = 16.409A, beta = 99.24 degrees, v = 7009.30A3, z = 4, F(000) = 3488, molecular weight M = 1756.90, Dc = 1.665g/cm3. It has been refined by the full matrix least squares method to final discrepancy factor R = 0.096. The anion [La2(EDTA)2(H2O)4]2- turns out to be a dimer, in which each of the two EDTA4- ions is coordinated to a La3+ ion with five of its six coordinating sites and the remaining sixth one--the oxygen atom of carboxylis bridged to two La3+ ions, thus forming a parallelogrammic four-membered ring La2O2. The nine coordinations about each metal are completed by two water molecules. The average bond length is 2.560 A for La-O and 2.833A for La-N. Approximately, the dimer belongs to point group Ci with the centre of inversion at the centre of La2O2 parallelogram. The antitumor activity of the coordination compound was studied by observing its effect on the incorporation of 3H-TdR into DNA of leukemia (L7712) cells in vitro. The degree of inhibition reached 83.9% after exposing 2 X 10(5) cells per millilitre to 4 X 10(-5) mol/L of the compound for 24 h, being higher than those of its precursors.
Chen
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Department of Chemistry, Lanzhou University.
Wang
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CH
Li
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Wang
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D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001580:Benzopyrenes / Q000138:chemical synthesis* / Q000494:pharmacology; D007942:Leukemia, Experimental / Q000473:pathology; D008968:Molecular Conformation; D009861:Onium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D001580:Benzopyrenes; D009861:Onium Compounds; D009942:Organometallic Compounds; C062072:3,6-di-(dimethylamino)-dibenzopyriodonium lanthanum-EDTA