The role of enteric bacteria in the anaerobic metabolism of 5-aminosalicylate.
The primary (and inactive) enteric metabolite of 5-aminosalicylate is N-acetyl-5-aminosalicylate. Previous studies have demonstrated acetylation of this anti-inflammatory agent by intestinal and bacterial homogenates. To assess the contribution of anaerobic bacteria to the N-acetylation in vivo, we have measured the production of N-acetyl-5-aminosalicylate in anaerobic microculture. Our results indicate that enteric bacteria play a minor role in N-acetylation, but may contribute to the production of other metabolites of pharmacologic and toxicological interest.
Tucker
M A
MA
Department of Health and Safety, Indiana State University, Terre Haute 47809.
Bisesi
M S
MS
Smith
T J
TJ
D000107:Acetylation; D000636:Aminosalicylic Acids / Q000378:metabolism*; D000693:Anaerobiosis / Q000502:physiology; D000818:Animals; D006224:Cricetinae; D004755:Enterobacteriaceae / Q000378:metabolism*; D019804:Mesalamine; D008647:Mesocricetus
D000636:Aminosalicylic Acids; D019804:Mesalamine