[Experimental studies on the role of retinal lipid peroxidation induced by intraocular iron foreign body].
Experimental studies were made to evaluate the role of lipid peroxidation in retinal damage by intraocular iron foreign bodies. It was found that after iron particles were implanted into the vitreous bodies (1) iron concentration in the aqueous humour rose rapidly and significantly (n = 24, P less than 0.01), (2) malondialdehyde (MDA) a degradation metabolite of lipid peroxidation, in the retinas increased significantly (n = 24, P less than 0.05), and (3) superoxide dismutase (SOD) activity decreased (n = 11, P less than 0.05). These findings suggest that lipid peroxidation plays a key role in the retinal damage of siderosis bulbi, and provide a solid basis in studying the pathogenesis and guiding clinical management of the disease.
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D000818:Animals; D005129:Eye Foreign Bodies / Q000150:complications*; D007501:Iron; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000378:metabolism; D011817:Rabbits; D012160:Retina / Q000378:metabolism*; D012164:Retinal Diseases / Q000209:etiology*; D013482:Superoxide Dismutase / Q000378:metabolism
D008315:Malondialdehyde; D007501:Iron; D013482:Superoxide Dismutase