title: Plasma elastase-alpha 1-antitrypsin, neopterin, tumor necrosis factor, and soluble interleukin-2 receptor after prolonged exercise.
abstract: The effects of a 2.5-h running test on the plasma concentrations of elastase-alpha 1-antitrypsin, neopterin, tumor necrosis factor, and soluble interleukin-2 receptor were evaluated in eight healthy young male subjects. Neopterin was measured by radioimmunoassay, elastase-alpha 1-antitrypsin, tumor necrosis factor, and soluble interleukin-2 receptor by enzyme immunoassay. The post-exercise values were corrected for plasma volume changes which were calculated from hematocrit and hemoglobin values. Compared with the concentrations before exercise, elastase-alpha 1-antitrypsin values were significantly increased during the run (1 h after the start) (P less than 0.01) as well as during the first few hours after the end of the running test (P less than 0.01). A significant increase of tumor necrosis factor and neopterin was observed 1 h after the end and 1,3, and 24 h after the end of the running test, respectively, (P less than 0.01), and soluble interleukin-2 receptor concentrations were significantly elevated 1 and 2 days after exercise (P less than 0.01). The increase of elastase-alpha 1-antitrypsin, neopterin, tumor necrosis factor, and soluble interleukin-2 receptor supports the concept of a functional involvement of polymorphonuclear neutrophils and an activation of macrophages and T-lymphocytes after prolonged exercise.
authors.affiliation: Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule Köln, FRG.
authors.forename: B
authors.initials: B
authors.lastname: Dufaux
authors.forename: U
authors.initials: U
authors.lastname: Order
mesh_terms: D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D005080:Exercise Test; D006801:Humans; D019272:Leukocyte Elastase; D008297:Male; D019798:Neopterin; D010196:Pancreatic Elastase / Q000097:blood* / Q000378:metabolism; D010807:Physical Endurance / Q000502:physiology*; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012420:Running; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
chemical_list: D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D000515:alpha 1-Antitrypsin; C037741:alpha 1-antitrypsin-leukocyte elastase complex; D001708:Biopterins; D019798:Neopterin; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase