[Nonspecific inherited risk factors for acute respiratory diseases in children living in the western part of the Baikal-Amur railway].
Variation of 9 polymorphic loci was compared in 2 groups of children from Russian native and migrant population of Western area of Baikal-Amur Railway--those who suffered from acute respiratory diseases during first year of life and their parents, and normal children and their parents. Frequencies of genotypes 1-1 (HP locus). 00 (ABO locus), and pp (F locus) were significantly higher in normal children than in the affected ones. Heterozygosity observed in native parents of the diseased children was lower as compared with other groups. It was possible to distinguish two groups, according to the degree of genic similarity: the first one included healthy children and their parents from migrant and native population, the second one included all affected children and their parents. Significance of association between phenotypes at 3 loci (HP, ABO, P) and predisposition of the children to acute respiratory diseases were evaluated. A conclusion was made that in children of both migrant and native Russian parents similar combinations of anthropological traits and gene markers are the factors of their nonspecific resistance to acute respiratory diseases.
Dubrova
Iu E
IuE
Shenin
V A
VA
Sedov
K R
KR
D002648:Child; D002874:Chromosome Mapping; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D012140:Respiratory Tract Diseases / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors; D012800:Siberia / Q000453:epidemiology
D005819:Genetic Markers
Nespetsificheskie nasledstvennye faktory riska ostrykh respiratornykh zabolevaniĭ u deteĭ, prozhivaiushchikh na zapadnom uchastke Baĭkalo-Amurskoĭ magistrali.