title: Biological N-oxidation of piperidine in vitro.
abstract: The biological N-oxidation of piperidine, a pharmacologically active biogenic amine of mammals and human beings, was studied in vitro. After incubation of piperidine-HCl in a fortified rat liver microsomal preparation (9000 x g supernatant) at 37 degrees C for 30 min, 2 metabolites were detected. They were identified as N-hydroxy piperidine and 2, 3, 4, 5-tetrahydro-pyridine-1-oxide as evidenced by TLC, GLC, HPLC, GC-MS and MS.
authors.forename: D Y
authors.initials: DY
authors.lastname: Wang
authors.forename: J W
authors.initials: JW
authors.lastname: Gorrod
authors.forename: A H
authors.initials: AH
authors.lastname: Beckett
mesh_terms: D000818:Animals; D001711:Biotransformation; D008862:Microsomes, Liver / Q000378:metabolism; D010880:Piperidines / Q000378:metabolism / Q000493:pharmacokinetics*; D011725:Pyridines / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010880:Piperidines; D011725:Pyridines; C062320:N-hydroxypiperidine; C043383:1-piperideine