title: An analysis on the rates and regulation of insensible water loss through the eccrine sweat glands.
abstract: An analysis is presented on insensible water loss from the human body at rest through exposed skin surfaces into still air. Possible sites of moisture release are identified as the stratum corneum of the skin, free surfaces of dilute sweat liquids perpetually present in the microscopic ducts of a large population of eccrine sweat glands, and moist microvillous processes which line part of the periductal surfaces in the glands, particularly in the helical coils within the stratum spinosum of the epidermis. Water supply to the sites involves transepidermal migration across skin tissue layers, secretion and partial reabsorption of solutes and water within eccrine glands, and transport across periductal lining of eccrine glands from the surrounding connective tissues respectively. Evaporation and gas phase diffusion within eccrine ducts were modelled. Basal loss rates of water (as regulated by the ambient temperature and relative humidity and by aspects of the anatomy of and physiological factors for eccrine glands, the epidermis and the dermis) were calculated at between 1 and 20 g hr-1 at an ambient temperature of 25 degrees C and a relative humidity of 60% as an example. Such rates are significant fractions of experimental values for insensible water loss rates reported at between 4 and 35 g hr-1 in air at 22-30 degrees C and a relative humidity of 30-60%.
authors.affiliation: Physiological Flow Studies Unit, Imperial College, London, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Jeje
authors.forename: D
authors.initials: D
authors.lastname: Koon
mesh_terms: D004439:Eccrine Glands / Q000033:anatomy & histology / Q000378:metabolism*; D006801:Humans; D006813:Humidity; D007700:Kinetics; D008954:Models, Biological; D013545:Sweat Glands / Q000378:metabolism*; D013696:Temperature; D014870:Water Loss, Insensible / Q000502:physiology*