title: Reversibility of pulmonary telangiectasia in liver cirrhosis evidenced by serial dynamic pulmonary perfusion imaging.
abstract: Pulmonary perfusion imaging with Tc-99m MAA revealed significant uptake in the lungs, brain, spleen, and both kidneys of a 48-year-old woman with liver cirrhosis and pulmonary telangiectasia associated with marked hypoxemia and cyanosis. Dynamic pulmonary perfusion imaging revealed a gradual reduction after peak uptake in both lungs. Several weeks after albumin replacement, the hypoxia and dyspnea disappeared with no change in hepatocellular function. At that time, dynamic pulmonary perfusion imaging revealed a plateau-like time-activity curve of uptake in the lungs, as compared with the findings obtained during the state of severe hypoxemia. These observations suggest that pulmonary telangiectasia in a patient with liver cirrhosis may be due to functional vasodilatation. Serial dynamic pulmonary perfusion imaging indicates the passage of the MAA particles through the widened lumen of the pulmonary alveolar capillaries.
authors.affiliation: Department of Internal Medicine, School of Medicine, Fukuoka University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Shijo
authors.forename: K
authors.initials: K
authors.lastname: Nakayama
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Ueki
authors.forename: S
authors.initials: S
authors.lastname: Sakaguchi
authors.forename: H
authors.initials: H
authors.lastname: Sakata
authors.forename: M
authors.initials: M
authors.lastname: Okumura
mesh_terms: D005260:Female; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D008103:Liver Cirrhosis / Q000150:complications / Q000000981:diagnostic imaging*; D008168:Lung / Q000098:blood supply / Q000000981:diagnostic imaging*; D008875:Middle Aged; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin; D013684:Telangiectasis / Q000000981:diagnostic imaging* / Q000209:etiology; D014692:Ventilation-Perfusion Ratio
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin