[A comparative study of the cryoprotective properties of dimethylacetamide and dimethyl sulfoxide in preserving thrombocytes at moderately low temperatures].
Comparative characteristics of cryoprotective properties of dimethylacetamide and dimethyl sulfoxide (DMAC and DMSO, respectively), used for freezing and storage of platelets at -80 degrees C, have been presented. It is shown that with the studied final concentrations of the cryoprotectors (5% of DMSO, 2.5% of DMAC), solutions containing DMSO display higher cryoprotective properties. Positive effect of autoplasma in the mixture with the platelet-protecting solution has been manifest in the maintaining of the functional properties of platelets after defrosting.
Azovskaia
S A
SA
Sukhanov
Iu S
IuS
Zhukovskaia
N L
NL
Konoplina
L A
LA
D000081:Acetamides / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D001793:Blood Preservation / Q000379:methods*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D015925:Cryopreservation / Q000379:methods*; D003451:Cryoprotective Agents / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D012996:Solutions; D013696:Temperature
D000081:Acetamides; D003451:Cryoprotective Agents; D012996:Solutions; C013959:dimethylacetamide; D004121:Dimethyl Sulfoxide
Sravnitel'noe izuchenie krioprotektornykh svoĭstv dimetilatsetamida i dimetilsul'foksida pri khranenii trombotsitov v usloviiakh umerenno nizkikh temperaturakh.