Antifertility plant products: testicular cell population dynamicsfollowing solasodine (C27H43O2N) administration in rhesus monkey (Macaca mulatta).
Solasodine obtained from the Solanum xanthocarpum berries was administered to Rhesus monkeys for 150 days to evaluate their effect on testicular cell population dynamics. Solasodine brings about an interference with spermiogenesis at the stage XII of late spermatids. The spermatids were decreased by 69% (P less than 0.001). No significant change was found in the population of spermatogonia/primary and secondary spermatocytes. The production of immature and mature Leydig cells were decreased by 60.4% and 41.6% respectively. A significant decrease in cauda sperm count (Control: 83.1 +/- 6.3; Solasodine 1.21 +/- 0.3 million/ml) was noticed. The testicular protein, sialic acid and glycogen contents were depleted following solasodine treatments to rhesus monkeys. Bioassay studies showed the antiandrogenic nature of the compound.
Dixit
V P
VP
Department of Zoology, University of Rajasthan, Jaipur/India.
Gupta
R S
RS
Gupta
S
S
D000818:Animals; D000988:Antispermatogenic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D007985:Leydig Cells / Q000166:cytology / Q000187:drug effects*; D008253:Macaca mulatta; D008297:Male; D009929:Organ Size; D012991:Solanaceous Alkaloids / Q000494:pharmacology*; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects*; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism
D000988:Antispermatogenic Agents; D012991:Solanaceous Alkaloids; C012037:solasodine