[Disorders of the "lipid peroxidation-antioxidant" system and ways of their correction after transplantation of vascularized tissue complexes].
An experimental investigation in 40 rabbits and 13 dogs has shown that arrest of blood flow in tissues is accompanied by activation of lipid peroxidation processes with reduced activity of the antioxidant system. Tissue anoxia during 4h sharply activates lipid peroxidation processes which is considerably aggravated after early performance of oxygenobarotherapy sessions (1h after revascularization). Relatively late sessions of oxygenobarotherapy (10h after the reestablishment of bloodflow) are not accompanied by activation of lipid peroxidation and decrease of the level of antioxidants of lipid nature, alpha-tocopherol acetate has a marked antioxidation effect and enhances tissue survival after anoxia.
Belousov
A E
AE
Tikhilov
R M
RM
Bilous
L I
LI
Syrbu
S S
SS
D000818:Animals; D000975:Antioxidants; D004285:Dogs; D006614:Hindlimb / Q000098:blood supply; D006931:Hyperbaric Oxygenation; D000860:Hypoxia / Q000209:etiology / Q000378:metabolism* / Q000628:therapy; D007511:Ischemia / Q000150:complications / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology*; D009132:Muscles / Q000098:blood supply* / Q000378:metabolism / Q000637:transplantation; D011817:Rabbits; D013482:Superoxide Dismutase / Q000172:deficiency*; D024505:Tocopherols; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives*; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000975:Antioxidants; D014810:Vitamin E; D013482:Superoxide Dismutase; D024502:alpha-Tocopherol; D024505:Tocopherols
Narusheniia v sisteme "perekisnoe okislenie lipidov"-anti-oksidanty" i puti ikh korrektsii pri transplantatsii krovosnabzhaemykh kompleksov tkaneĭ.