Hepatoxicity evaluation in rats given a single overdose of Acetaminophen (Paracetamol).
Of the various parameters measured in the Serum of rats given a single overdose of acetaminophen (APAP), methaemoglobin (M-Hb) free and conjugated bilirubin seem to be better diagnostic indicators of APAP poisoning than alkaline phosphatase (ALP).
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D000082:Acetaminophen / Q000633:toxicity*; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D008107:Liver Diseases / Q000097:blood / Q000150:complications; D008297:Male; D008708:Methemoglobinemia / Q000097:blood / Q000209:etiology; D051381:Rats
D000082:Acetaminophen; D000469:Alkaline Phosphatase; D001663:Bilirubin