[Spinal reflexes and somatosensory evoked potentials studied in the baboon in the presence of anti-arrhythmic drugs].
Intragastric administration of the anti-arrhythmic drugs CM 7857 (Sanofi) or disopyramide, as expected, significantly reduced the heart rate in normal baboons at rest. At the same time, the variability in the heart rate increased. In vitro studies by Sanofi have previously shown the anti-arrhythmic effects of these drugs, i.e., a slowing of the transmembrane currents evidenced in several categories of heart cells especially when activated. Similar ion currents are known to be involved in extracardiac sensory-motor activities. However the H-reflex in soleus underwent no systematic changes in latency or amplitude with the drugs; the non-nociceptive early and nociceptive late polysynaptic responses elicited in the tibialis anterior muscle by sural nerve stimulation demonstrated a barely perceptible increase in integrated EMG value. No change could be seen in latency or amplitude of the cortical potentials evoked by sciatic or sural stimulation which was also used for reflex responses. Overall there was no definitive evidence of change in the extra-cardiac sensory-motor responses in the normal awake monkey, after administration of relatively high doses of the cardio-active compounds.
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Université de Provence, URA CNRS 372, Dpt de psychophysiologie, Centre de Saint-Jérome, Marseille, France.
el Kharroussi
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Vilain
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Hugon
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D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D004206:Disopyramide / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D010215:Papio; D011437:Propylamines / Q000494:pharmacology*; D011725:Pyridines; D012018:Reflex / Q000187:drug effects*; D012119:Respiration / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology
D000889:Anti-Arrhythmia Agents; D011437:Propylamines; D011725:Pyridines; C045930:propisomide; D004206:Disopyramide
Réflexes spinaux et potentiels évoqués somesthésiques étudiés chez le babouin en présence de drogues anti-arythmiques.