title: Juvenile versus maturity-onset alopecia areata--a comparative retrospective clinical study.
abstract: We report a retrospective study of 209 patients presenting with alopecia areata (AA) at our skin department during the period 1969-1987, with special reference to possible associations, aetiological factors and the relevance of additional investigations. The patients were divided into two groups: (I) those in whom AA developed during childhood; (II) those in whom AA developed in adult life (greater than or equal to 16 years). The aim of this study was to establish whether there is a difference between juvenile and maturity-onset AA and to consider the value of additional investigations in AA. Juvenile AA is more severe and has a less favourable prognosis than the maturity-onset disease. Statistically significant differences between the two groups were not found with respect to AA type and prevalence of auto-antibodies. Bad prognostic signs in AA were early age of onset, atopy (or first-degree family history) and ophiasis and/or onychodystrophy. Initial thyroid function testing seems advisable in patients with AA. Additional valuable investigations may include hair-root examination, determination of antibodies against thyroid tissue, and serum zinc levels. There are indications that psychosomatic factors may play a role in AA. In our study, psychosomatic factors were found in 29% of the juvenile AA and in 17% of the maturity-onset AA patients.
authors.forename: F B
authors.initials: FB
authors.lastname: De Waard-van der Spek
authors.forename: A P
authors.initials: AP
authors.lastname: Oranje
authors.forename: D M
authors.initials: DM
authors.lastname: De Raeymaecker
authors.forename: J D
authors.initials: JD
authors.lastname: Peereboom-Wynia
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000506:Alopecia Areata / Q000145:classification* / Q000276:immunology / Q000523:psychology; D001323:Autoantibodies / Q000032:analysis; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications; D008297:Male; D009260:Nail Diseases / Q000150:complications; D011379:Prognosis; D011602:Psychophysiologic Disorders; D012189:Retrospective Studies
chemical_list: D001323:Autoantibodies