title: Antipyretic activity of diacetyl para-amino phenol.
abstract: Diacetyl para-amino phenol (DAPAP) was generated by interaction between aspirin and paracetamol in a mechanical shaker. It revealed antipyretic activity in albino rats. The antipyretic action was found to be having the same onset of action and duration as that of aspirin. This compound lacked ulcerogenic and analgesic activity. DAPAP therefore may have safety as an antipyretic drug in patients with history of peptic ulcer.
authors.affiliation: Department of Pharmaceutical Sciences, University of Nagpur.
authors.forename: P
authors.initials: P
authors.lastname: Sewak
authors.forename: J
authors.initials: J
authors.lastname: Saxena
authors.forename: A K
authors.initials: AK
authors.lastname: Dorle
authors.forename: J K
authors.initials: JK
authors.lastname: Grover
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology / Q000633:toxicity; D000627:Aminophenols / Q000494:pharmacology* / Q000633:toxicity; D000700:Analgesics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity; D005260:Female; D008297:Male; D051379:Mice; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced
chemical_list: D000627:Aminophenols; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; C098626:4-diacetylaminophenol