Diterpene sclareol glycol inhibits clonidine-induced aggressive responses in mice.
The effects of a reversible activator of adenylate cyclase sclareol glycol (SG), a semisynthetic diterpene of the labdane family, on the aggressive behavior induced by a high dose of clonidine in mice were studied. SG was applied at doses well below the lethal dose. Aggressive behavior induced by clonidine at a dose of 30 mg/kg IP was decreased in a dose-dependent manner by SG (1, 5, 25 mg/kg IP). The aggressive responses were abolished by doses of 50 and 100 mg/kg. It is suggested that the inhibitory effects of SG on clonidine-induced aggressive behavior are realized mainly via its effect on adenylate cyclase and perhaps involving synaptic transmitter action.
Georgieva
J V
JV
Institute of Pharmacology and Pharmacy, Medical Academy, Sofia, Bulgaria.
D000374:Aggression / Q000187:drug effects*; D000378:Agonistic Behavior / Q000187:drug effects*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D004224:Diterpenes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice
D004224:Diterpenes; D003000:Clonidine; C060464:sclareol glycol