Interleukin-2 receptor positive cells and circulating soluble interleukin-2 receptors in patients with solid tumors are not correlated.
Activated lymphocytes can release a soluble form of IL-2 receptor (sIL-2R), which retains the capacity to bind IL-2. Abnormally high values of sIL-2R have been observed in patients with advanced solid tumors. In an attempt to further understand the biological significance of sIL-2R in solid tumors, this study investigated the relation between sIL-2R and Tac-positive cells. sIL-2R serum levels and Tac-positive cells were determined in 18 patients with solid tumors metastatic, 108 non-metastatic. Tumor types were: breast 7; lung 6; colon 2; stomach 1; testis 1; larynx 1. No correlation was found between circulating sIL-2R values and Tac-positive cells, and there was no difference between Tac-positive cell mean number in patients with high and normal sIL-2R levels. These preliminary results suggest that different mechanisms are responsible for sIL-2R release in the blood and IL-2 receptor expression on the immune cell surface.
Lissoni
P
P
Division of Radiation Oncology, Ospedale San Gerardo, Monza (Mi), Italy.
Rizzo
V
V
Barni
S
S
Rescaldani
R
R
Rovelli
F
F
Biondi
A
A
Archili
C
C
Frigerio
F
F
Tancini
G
G
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000276:immunology; D009369:Neoplasms / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000097:blood / Q000378:metabolism*; D012995:Solubility
D014408:Biomarkers, Tumor; D015375:Receptors, Interleukin-2