Methylazoxymethanol acetate (MAM ac) effects on the ontogenesis of the mouse neocortex.
Methylazoxymethanol acetate (MAM ac) injected prenatally affects development of neocortex in mice. Treatment at 13 days of gestation results in cortical hypoplasia that affects all the cortical layers except the first. Treatment at 15 days of gestation causes a statistically significant reduction in cell density in the superficial layers, while the deepest layers show no significant differences compared to the controls. Treatment at 17 days of gestation causes an alterated arrangement of the cortical layers, not easily separable since MAM ac in limiting perhaps glial cell proliferation, modifies the subsequent migration mechanisms. Fetal MAM exposure prevents proliferation of the various cortical laminae and there aren't subsequent compensatory phenomena.
Ciaroni
S
S
Institute of Morphological Sciences, University of Urbino, Italy.
Cecchini
T
T
Gazzanelli
G
G
Del Grande
P
P
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D002452:Cell Count; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects / Q000196:embryology*; D005314:Embryonic and Fetal Development / Q000187:drug effects; D008746:Methylazoxymethanol Acetate / Q000031:analogs & derivatives / Q000494:pharmacology*; D051379:Mice; D008938:Mitosis / Q000187:drug effects
D000477:Alkylating Agents; D001391:Azo Compounds; D008746:Methylazoxymethanol Acetate; C030667:methylazoxymethanol