Lipid peroxidation and free radical scavengers in Alzheimer's disease.
Lipid peroxidation products and defenses against free radical damage were determined in serum of 55 patients with senile dementia of the Alzheimer type (SDAT) and compared with values in 24 age-matched healthy control subjects. The following parameters were evaluated: lipid-conjugated dienes and trienes, malondialdehyde, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in erythrocytes, vitamins E, C and A, zinc, selenium and copper, ceruloplasmin, transferrin and albumin. The results showed a statistically significant decrease in the levels of GSH-Px, vitamins E, C and A, zinc, transferrin and albumin in the SDAT group. On the other hand, most of the deficiencies concern the malnourished subgroup of the SDAT population (SOD, GSH-Px, vitamins E and C, selenium, zinc, transferrin and albumin). Such an alteration of free radical scavengers in the malnourished subgroup of the SDAT population could combine the radical and nutritional hypothesis advanced by some authors.
Jeandel
C
C
Internal Medicine and Geriatric Service, CHU Nancy-Brabois, Vandoeuvre-lès-Nancy, France.
Nicolas
M B
MB
Dubois
F
F
Nabet-Belleville
F
F
Penin
F
F
Cuny
G
G
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D002570:Ceruloplasmin / Q000032:analysis; D003300:Copper / Q000097:blood; D005260:Female; D005609:Free Radicals; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D009752:Nutritional Status; D012643:Selenium / Q000097:blood; D012709:Serum Albumin / Q000032:analysis; D013482:Superoxide Dismutase / Q000097:blood; D014168:Transferrin / Q000032:analysis; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood; D015032:Zinc / Q000097:blood
D005609:Free Radicals; D012709:Serum Albumin; D014168:Transferrin; D014801:Vitamin A; D014810:Vitamin E; D003300:Copper; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D012643:Selenium; D015032:Zinc; D001205:Ascorbic Acid