title: Idiotypic network in myasthenia gravis.
abstract: Fluctuations in idiotypic and anti-idiotypic Ab levels over time in two myasthenia gravis patients were found to vary either inversely with one another or in relation to one another. A pair of 46-year-old female twins in which one of the twins developed myasthenia gravis while the other remained healthy were also studied. Ab specificities and immunoglobulin specificities available in the B cell repertoire were found to be similar in both twins.
authors.affiliation: Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Eng
authors.forename: A K
authors.initials: AK
authors.lastname: Lefvert
mesh_terms: D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000378:metabolism; D001323:Autoantibodies / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000378:metabolism*; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000276:immunology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D007130:Immunoglobulin Idiotypes