title: Susceptibility of Brucella melitensis to fluoroquinolones.
abstract: In vitro activity of four fluoroquinolones and four other antibacterial agents was tested against clinical isolates of Brucella melitensis. Initially all the 146 isolates studied were inhibited by 0.06-0.5 mg/l of ciprofloxacin and fleroxacin and 0.12-0.5 mg/l of pefloxacin or norfloxacin. One of these isolates developed resistance during therapy with ciprofloxacin, with a rise in MIC from 0.06 mg/l to more than 5.0 mg/l. This strain also showed cross-resistance to all other quinolones. All the isolates remained susceptible to tetracycline, gentamicin, rifampicin and trimethoprim-sulfamethoxazole. None of the quinolones showed in vitro synergy with other antibiotics.
authors.affiliation: King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors.forename: S M
authors.initials: SM
authors.lastname: Qadri
authors.forename: M
authors.initials: M
authors.lastname: Akhtar
authors.forename: Y
authors.initials: Y
authors.lastname: Ueno
authors.forename: M B
authors.initials: MB
authors.lastname: al-Sibai
mesh_terms: D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002002:Brucella / Q000187:drug effects*; D002006:Brucellosis / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents