title: The major pectic arabinogalactan having activity on the reticuloendothelial system from the roots and rhizomes of Saposhnikovia divaricata.
abstract: The major acidic polysaccharide, named saposhnikovan A, was isolated from the roots and rhizomes of Saposhnikovia divaricata. It showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of L-arabinose: D-galactose: D-galacturonic acid in the molar ratio of 6:15:10, and its molecular weight was estimated to be 54000. About 35% of the D-galacturonic acid residues exist as the methyl esters. Methylation analysis, 13C-nuclear magnetic resonance, and controlled Smith degradation studies indicated that the polysaccharide has the alpha-1----4-linked D-galacturonan backbone bearing alpha-1----5-linked L-arabino-beta-3,6-branched D-galactan side chains.
authors.forename: N
authors.initials: N
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Tomoda
authors.forename: R
authors.initials: R
authors.lastname: Gonda
authors.forename: M
authors.initials: M
authors.lastname: Kanari
authors.forename: N
authors.initials: N
authors.lastname: Takanashi
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000032:analysis* / Q000494:pharmacology; D005685:Galactans / Q000032:analysis*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012157:Mononuclear Phagocyte System / Q000187:drug effects*
chemical_list: D004365:Drugs, Chinese Herbal; D005685:Galactans; C005653:arabinogalactan