Use of cytotoxic drugs with an end-line filter--a study of four drugs commonly administered to paediatric patients.
The absorption of Novantrone (Mitozantrone), Adriamycin (Doxorubicin Hydrochloride), Cerubidin (Daunorubicin) and methotrexate to 0.2-microM endotoxin-retentive end-line filters was studied under simulated infusion conditions. The drugs were injected into a burette containing saline and then infused using an infusion pump set at 100 ml/h or 80 ml/h. Filtrate samples were collected over a total period of 2.5 h and assayed spectrophotometrically. Recovery of all four drugs following filtration was 96% or greater; indicating absence of absorption by the end-line filters used.
Stevens
R F
RF
Royal Manchester Children's Hospital, Pendlebury, U.K.
Wilkins
K M
KM
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003630:Daunorubicin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005374:Filtration / Q000295:instrumentation; D007260:Infusion Pumps; D008727:Methotrexate / Q000008:administration & dosage; D008942:Mitoxantrone / Q000008:administration & dosage; D010372:Pediatrics; D013053:Spectrophotometry
D000970:Antineoplastic Agents; D004317:Doxorubicin; D008942:Mitoxantrone; D008727:Methotrexate; D003630:Daunorubicin