Antitumor agents, 110. Bryophyllin B, a novel potent cytotoxic bufadienolide from Bryophyllum pinnatum.
Bryophyllin B [1], a potent cytotoxic bufadienolide, has been isolated from Bryophyllum pinnatum and its structure confirmed by the use of 2D-nmr techniques and difference nOe method. Transformation of bryotoxin C [2] to 1 with acid is also discussed.
Yamagishi
T
T
Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
Haruna
M
M
Yan
X Z
XZ
Chang
J J
JJ
Lee
K H
KH
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D002018:Bufanolides / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010944:Plants / Q000032:analysis*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D002018:Bufanolides; C062199:bryophyllin B