Synthesis, structure and cytostatic activity of a series of N-substituted 3,4-diphenyl-1H-pyrrole-2,5-diones.
A series of N-substituted 3,4-diphenyl-1H-pyrrole-2,5-diones (diphenylmaleimides) (IV) were synthesized and tested for cytostatic activity. Compounds IVa--k were prepared from diphenylmaleic anhydride or its dinitro derivative (V or VI) and the corresponding amine. Compounds IVl--n were obtained by reaction of 3-(p-nitrophenyl)-4-phenyl-1H-pyrrole-2,5-dione potassium salt with the appropriate chloroalkylamine. Hydrogenation of IVl,n gave the the corresponding cis-3-(p-aminophenyl)-4-phenylsuccinimides (VIIIa,b). The structure-cytostatic activity relationship of these compounds is discussed.
Fernández Braña
M
M
Fernández
A
A
Garrido
M
M
López Rodríguez
M L
ML
Morcillo
M J
MJ
Sanz
A M
AM
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006367:HeLa Cells; D006801:Humans; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011758:Pyrroles