Synthesis and pharmacological activity of imidazolyn-5-ones.
A new series of imidazolyn-5-one derivatives were synthesized. These compounds were screened for their analgesic, anti-inflammatory and antipyretic activities, as well as for their ulcerogenic potential, for behavioural effects and acute toxicity. Some of them showed higher analgesic activity than phenylbutazone (PBZ), but lower anti-inflammatory activity. Their ulcerogenic effect was lesser than that of the reference drug.
Bousquet
E
E
Istituto Di Chimica Farmaceutica E Tossicologica, Facoltà Di Farmacia, Università Di Catania, Italy.
Romeo
G
G
Santagati
N A
NA
Lancetta
T
T
Caruso
A
A
Leone
V
V
Felica
A
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000503:physiopathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007093:Imidazoles