title: [Derivatives of daunorubicin containing an inosine fragment].
abstract: Condensation of daunorubicin or its (13 R, S)-dihydro derivative with inosine dialdehyde in the presence of NaBH3CN yielded novel derivatives of anthracycline antibiotics with incorporated inosine residue: 3'-deamino-3'-[(2" R)-(hypoxanthyl-9)-(6" S)-hydroxymethylmorpholino-N4"]- daunorubicin and (13 R,S)-dihydro-3'-deamino-3'-[(2" R)-(hypoxanthyl-9)-(6" S)- hydroxymethylmorpholino-N4"]-daunorubicin. The compounds did not inhibit growth of Bacillus mycoides and were less cytotoxic in vitro and less toxic in vivo than the parent antibiotics.
authors.forename: E N
authors.initials: EN
authors.lastname: Olsuf'eva
authors.forename: N P
authors.initials: NP
authors.lastname: Todorova
authors.forename: I V
authors.initials: IV
authors.lastname: Iartseva
authors.forename: B V
authors.initials: BV
authors.lastname: Rozynov
authors.forename: N G
authors.initials: NG
authors.lastname: Shepelevtseva
authors.forename: M N
authors.initials: MN
authors.lastname: Preobrazhenskaia
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001407:Bacillus / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000494:pharmacology; D007288:Inosine; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000903:Antibiotics, Antineoplastic; D007288:Inosine; D003630:Daunorubicin
vernacular_title: Proizvodnye daunorubitsina, soderzhashchie fragment inozina.