title: Autoantibodies against a nuclear 56 kDa protein: a marker for inflammatory muscle disease.
abstract: Antibodies to a 56 kDa nuclear protein have been found in the sera of 85% of patients with myositis using an immunoblotting technique. This auto-antibody appears to be relatively disease-specific though more frequently detectable in both adult and childhood onset dermatomyositis. In adult patients with myositis the anti-56 kDa antibody level reflects disease activity. This antibody is thus much more frequently found than previously described disease-specific autoantibodies in patients with myositis such as the Jo-1 antibody, and may represent a useful diagnostic aid in patients with muscle weakness.
authors.affiliation: Department of Genetics, Hebrew University of Jerusalem, Israel.
authors.forename: H
authors.initials: H
authors.lastname: Arad-Dann
authors.forename: D
authors.initials: D
authors.lastname: Isenberg
authors.forename: E
authors.initials: E
authors.lastname: Ovadia
authors.forename: Y
authors.initials: Y
authors.lastname: Shoenfeld
authors.forename: J
authors.initials: J
authors.lastname: Sperling
authors.forename: R
authors.initials: R
authors.lastname: Sperling
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood* / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000150:complications / Q000276:immunology*; D015415:Biomarkers; D002461:Cell Line, Transformed; D016009:Chi-Square Distribution; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015151:Immunoblotting; D008297:Male; D008970:Molecular Weight; D009220:Myositis / Q000150:complications / Q000276:immunology*; D009369:Neoplasms / Q000150:complications / Q000276:immunology; D055517:snRNP Core Proteins
chemical_list: D000974:Antibodies, Antinuclear; D001324:Autoantigens; D015415:Biomarkers; D055517:snRNP Core Proteins; D003402:Creatine Kinase