Effect of plasmapheresis on the liver uptake of ApoB-lipoproteins labeled with technetium-99m.
To study liver low density lipoprotein (LDL)-receptor activity before and after plasmapheresis, [99mTc] very low density lipoprotein (VLDL) was used. Autologous VLDL was labeled, sterilized by filtration, and administered intravenously to patients under a gamma camera. The uptake of lipoproteins in the liver was measured by scintiscanning. Liver activity curves were generated for each patient. The liver activity in patients with the heterozygous form of familial hypercholesterolemia (FH) and in patients with symptomatic atherosclerosis (SA) without hereditary deficit of LDL receptors was reduced as compared to healthy people. Plasmapheresis enhanced the liver uptake of the 99mTc-labeled lipoproteins in atherosclerotic patients. Thus, labeled metabolites could presumably be of use in assessing the effect of plasmapheresis on liver function.
Anisimova OJu
USSR Cardiology Research Center, Moscow.
Konovalov
G A
GA
Agapov
I I
II
Fuki
I V
IV
Sergienko
V B
VB
Repin
V S
VS
Kukharchuk
V V
VV
D000328:Adult; D001055:Apolipoproteins B; D001161:Arteriosclerosis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000000981:diagnostic imaging; D006938:Hyperlipoproteinemia Type II / Q000000981:diagnostic imaging; D008079:Lipoproteins, VLDL; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D010956:Plasmapheresis; D011877:Radionuclide Imaging; D013667:Technetium
D001055:Apolipoproteins B; D008079:Lipoproteins, VLDL; D013667:Technetium