[Stabilization of antiviral activity of porcine leukocytic interferon].
Unithiol (2,3-dimercaptopropan-sodium sulphonate) has been found to be an effective, nontoxic stabilizer of antiviral activity of labile interferons. The optimum stabilizing concentration of unithiol is 0.07%: at this concentration its protective effect is maximum with the lowest content of the substance. Unithiol at this concentration retains about 66% of the initial antiviral activity in acid medium (pH 2.0) and up to 75% of the initial antiviral activity on mechanical exposure.
Georgadze
I I
II
Chigogidze
N Sh
NSh
Topuriia
N V
NV
Khasenova
Z Kh
ZKh
Bukhnikashvili
I L
IL
D000818:Animals; D000998:Antiviral Agents; D002460:Cell Line; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007370:Interferon Type I / Q000494:pharmacology*; D013314:Stress, Mechanical; D013552:Swine; D014494:Unithiol
D000998:Antiviral Agents; D007370:Interferon Type I; D014494:Unithiol
Stabilizatsiia protivovirusnoĭ aktivnosti svinogo leĭkotsitarnogo interferona.