title: Isolation and characterization of agglomerins A, B, C and D.
abstract: New antibiotics, agglomerins A, B, C and D, were isolated from the culture broth of a bacterial strain identified as Enterobacter agglomerans. These antibiotics are acidic in nature and their sodium salts are obtained as colorless crystalline powders, soluble in lower alcohols. All the antibiotics shows characteristic UV maxima at 248 and 298 nm. Molecular formulas: A, C15H21O4Na; B, C17H23O4Na; C, C17H25O4Na and D, C19H27O4Na; were indicated by elemental analysis and MS. These antibiotics are active against a wide variety of anaerobic bacteria and weakly against aerobic Gram-positive bacteria in vitro.
authors.affiliation: Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Shoji
authors.forename: R
authors.initials: R
authors.lastname: Sakazaki
authors.forename: T
authors.initials: T
authors.lastname: Hattori
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: N
authors.initials: N
authors.lastname: Uotani
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004754:Enterobacter / Q000032:analysis; D005285:Fermentation; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; C063061:agglomerin A; C063062:agglomerin B; C063063:agglomerin C; C063064:agglomerin D; D015107:4-Butyrolactone