[Investigation of the functional properties of domains of alpha-actinin].
The role of domains in rabbit skeletal muscle alpha-actinin was investigated. The binding center of alpha-actinin containing F-actin is localized in the N-terminal domain, while the C-terminal domain provides for dimerization of the protein molecule. A model of structural organization of the alpha-actinin was proposed, according to which the subunits within the molecule are oriented so that the N-terminal domains localized on the opposite sides of the protein molecule form the binding centers of alpha-actinin with F-actin.
Simonidze
M Sh
MSh
Kuridze
K Sh
KSh
Nadirashvili
N Sh
NSh
Zaalishvili
M M
MM
D000185:Actinin / Q000378:metabolism*; D000199:Actins / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D004591:Electrophoresis, Polyacrylamide Gel; D009132:Muscles / Q000378:metabolism; D011817:Rabbits
D000199:Actins; D000185:Actinin
Issledovanie funktsional'nykh svoĭstv domenov alpha-aktinina.