[The protective action of different types and regimens of adaptation to hypoxia on the development of stress-induced lesions in KM strain (Krushinskiĭ-Molodkina) rats].
The effect of preliminary adaptation to hypoxia on the development of stress-induced lesions was studied on the model of acoustic stress in the Krushinskiĭ-Molodkina line rats genetically predisposed to audiogenic seizures. At different regimens of adaptation to hypoxia (long- and short-term, continuous, intermittent), a decrease of the death rate, severity of motor disorders, incidence and degree of intracranial hemorrhages occurred. Only when using a hypoxic gas mixture, a reduction of excitability of the c.n.s. was revealed: the latency increased whereas the intensity of the seizure decreased. Two-hour normobaric hypoxic stimulation prevented an increase in the lipid peroxidation products and contributed to a rise of cyclic nucleotides concentration in the brain hemispheres of the KM line rats exposed to acoustic stress.
Krushinskiĭ
A L
AL
Riasina
T V
TV
Koshelev
V B
VB
Sotskaia
M N
MN
Bebinov
E M
EM
D000161:Acoustic Stimulation; D000222:Adaptation, Physiological / Q000502:physiology*; D000531:Altitude; D000818:Animals; D001273:Atmosphere Exposure Chambers; D001921:Brain / Q000378:metabolism; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D009712:Nucleotides, Cyclic / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*; D012640:Seizures / Q000503:physiopathology; D013312:Stress, Physiological / Q000209:etiology* / Q000503:physiopathology; D013997:Time Factors
D009712:Nucleotides, Cyclic
Protektornoe deĭstvie raznykh vidov i rezhimov adaptasii k gipoksii na razvitie stressovykh povrezhdeniĭ u krys linii KM.