Longitudinal study of serum antibody response to bovine corneal protein (BCP 54) in Behçet's disease.
Serum samples from a patient diagnosed as having active Behçet's syndrome with iritis were evaluated by the enzyme-linked immunosorbent assay for antibodies against a purified bovine corneal protein, molecular weight 54,000 daltons (BCP 54). Significantly elevated antibody levels to BCP 54 were found in all serum samples collected over a 2-year period. Anti-BCP 54 antibody levels remained within a very narrow range, at least twofold higher than those of controls. In contrast, no antibody to retinal S antigen was detected. These results indicate the presence of specific anti-BCP 54 autoantibodies in sera from a Behçet's patient and suggest that autoantibodies may play a role in the etiopathogenesis of uveitis.
Kong
A S
AS
Department of Ophthalmology, Mount Sinai School of Medicine of the City University of New York, N.Y.
Henley
W L
WL
Luntz
M H
MH
D000293:Adolescent; D000444:Aldehyde Dehydrogenase; D000906:Antibodies / Q000032:analysis / Q000276:immunology; D000941:Antigens / Q000276:immunology; D019393:Arrestin; D001528:Behcet Syndrome / Q000150:complications / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D005136:Eye Proteins / Q000276:immunology*; D006801:Humans; D007500:Iritis / Q000150:complications / Q000276:immunology; D008137:Longitudinal Studies
D000906:Antibodies; D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins; C030863:corneal protein 54, bovine; D000444:Aldehyde Dehydrogenase