title: [The fibronectin deficiency in normal newborn infants corrects itself very quickly].
abstract: Fibronectin (FN) is a protein which acts as an opsonin and participates in anti-infective mechanisms. We measured FN in cord blood from 39 normal newborns by Laurell's electroimmunoassay. The mean value of FN was 13.5 +/- 6.8 mg/dl, lesser then mean value of 26 normal children 1 mo. to 7 y. old, 27.3 +/- 8.7 mg/dl (p less than 0.001). FN continued being low, 14.1 +/- 8.1 mg/dl al 48 h. of age. Nevertheless it was normal at 15 days of age (24.6 +/- 9.7 mg/dl). FN levels were lower at 15 days of age in 19 newborns who received vitamin K (12.2 +/- 6.1 mg/dl) than in the group which was not treated (18.1 +/- 9.9 mg/dl) but the difference was not significant (p greater than 0.05). There was a close correlation between cord blood levels and levels at 48 h. (p = 0.001) and levels at 15 d. (p = 0.003). There was no relationship either with the gestational age and birth weight, no prothrombin and protein C levels. The FN decrease in the newborn can be one of the causes of the opsonization deficiency, nevertheless normalization occurred very soon, before the second week.
authors.affiliation: Facultad de Medicina, Departamento de Pediatría, Valladolid, España.
authors.forename: A
authors.initials: A
authors.lastname: Blanco Quirós
authors.forename: M R
authors.initials: MR
authors.lastname: Bachiller Luque
authors.forename: F J
authors.initials: FJ
authors.lastname: Alvarez Guisasola
authors.forename: H
authors.initials: H
authors.lastname: González García
authors.forename: C
authors.initials: C
authors.lastname: Blanco Quirós
mesh_terms: D000367:Age Factors; D005312:Fetal Blood / Q000032:analysis; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000097:blood* / Q000276:immunology; D009895:Opsonin Proteins; D012016:Reference Values; D014812:Vitamin K / Q000008:administration & dosage
chemical_list: D005353:Fibronectins; D009895:Opsonin Proteins; D014812:Vitamin K
vernacular_title: La deficiencia de fibronectina en recién nacidos normales se corrige muy pronto.