Synthesis and properties of 7-methyl-5-oxo-1,5-dihydro-8-[1,2,4]-triazolo [4,3-c]pyrimidinecarboxylic acid derivatives.
The synthesis of the new triazolo[4,3-c]pyrimidines is described, starting from derivatives of 5-carboxy-2-hydroxy-4-hydrazino-6-methylpyrimidine. The 4-methyl-2,3-dihydropyrazolo[3,4-d]pyrimidine-3,6-dione was also obtained. Some of triazolo[4,3-c]pyrimidines tested for biological activity were found inactive.
Długosz
A
A
Department of Organic Chemistry, School of Medicine, Faculty of Pharmacy, Wrocław, Poland.
Machoń
Z
Z
Jasztold-Howorko
R
R
D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D012510:Sarcoma 180 / Q000188:drug therapy; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000700:Analgesics; D000927:Anticonvulsants; D000959:Antihypertensive Agents; D000970:Antineoplastic Agents; D011743:Pyrimidines; D014230:Triazoles