[Pentagastrin modulation of the neuronal sensitivity of the lateral hypothalamus to noradrenaline and dopamine].
Experimental study is dedicated to mechanisms of interaction of pentagastrin and monoamines (noradrenaline and dopamine) at the level of single neurones of the rabbits lateral hypothalamus under alimentary motivation and under saturation. It is shown that pentagastrin can modulate the effects of noradrenaline and dopamine on neuronal impulse activity in hungry and fed up animals, and the character of its action depends on the rabbits initial state. It is suggested that pentagastrin is a factor initiating alimentary motivational excitation, while noradrenaline maintains the latter at the definite level up to obtaining useful result by the animal, when dopaminergic mechanisms participating in the process of reinforcement join the noradrenergic ones.
Borisova
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EV
Philipp
M
M
D000818:Animals; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D005508:Food Deprivation / Q000502:physiology; D007026:Hypothalamic Area, Lateral / Q000187:drug effects* / Q000502:physiology; D007478:Iontophoresis; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits
D010418:Pentagastrin; D004298:Dopamine; D009638:Norepinephrine
Moduliatsiia pentagastrinom chuvstvitel'nosti neĭronov lateral'nogo gipotalamusa k noradenalinu i dofaminu.