The effect of sucralfate pretreatment on the pharmacokinetics of ciprofloxacin.
Based on the results of our study of norfloxacin-sucralfate coadministration, we suspected that sucralfate would interact also with ciprofloxacin if the drugs were administered concurrently. Therefore, we decided to give a 1-g dose of sucralfate at 6 and 2 hours before a single 750-mg dose of ciprofloxacin and evaluate its effect on the bioavailability of ciprofloxacin. Twelve healthy, male volunteers received ciprofloxacin alone and with sucralfate pretreatment in a randomized, balanced, crossover design. Blood and urine samples were collected over 24 hours after ciprofloxacin administration, and drug concentrations were assayed by high-performance liquid chromatography. When sucralfate was given at 6 and 2 hours before ciprofloxacin, an average 30% decrease in ciprofloxacin's bioavailability was noted (p less than 0.05). Four of the 12 subjects, however, had decreases in the agent's area under the curve of more than 50% with sucralfate pretreatment. The results of this study suggest that ciprofloxacin and sucralfate should not be administered concurrently until a dosing interval is found that will avoid this potential interaction.
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DE
State University of New York, Buffalo School of Pharmacy.
Watson
W A
WA
Handy
L
L
Frost
R W
RW
Rescott
D L
DL
Goldstein
H R
HR
D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D011292:Premedication; D011897:Random Allocation; D013392:Sucralfate / Q000097:blood / Q000494:pharmacology*
D013392:Sucralfate; D002939:Ciprofloxacin