Clinical and pharmacokinetic study of intraperitoneal cisplatin at two dose levels: 100 mg/m2 alone or 200 mg/m2 with i.v. sodium thiosulfate.
In 22 patients cisplatin was infused intraperitoneally in 70 cycles using a dose of 100 and 200 mg/m2. The ratio between peritoneal and plasma AUC was between 10 and 20. No patient showed an objective remission.
Canal
P
P
Unités de Pharmacocinétique et de Pharmacologie Clinique, Université Paul Sabatier, Toulouse, France.
de Forni
M
M
Chatelut
E
E
Chevreau
C
C
Johnson
N P
NP
Houin
G
G
Bugat
R
R
D000230:Adenocarcinoma / Q000188:drug therapy; D000931:Antidotes; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D015179:Colorectal Neoplasms / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D007263:Infusions, Parenteral / Q000295:instrumentation; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy; D010534:Peritoneal Neoplasms / Q000097:blood / Q000188:drug therapy*; D010865:Pilot Projects; D013885:Thiosulfates / Q000008:administration & dosage*
D000931:Antidotes; D013885:Thiosulfates; C017717:sodium thiosulfate; D002945:Cisplatin