Steriological analysis of peritumoral lymph nodes in patients operated for cervical and endometrial cancer after being treated with thymostimulin.
We have evaluated, by means of stereological analysis, the dimensions of the lymph node functional areas (cortical, medullary, paracortical, histiocytosis of the sinuses, germinal centers) in regional lymph nodes of women with cervical cancer (15 women) and endometrial carcinoma (6 women) in Ist and IInd stage, treated 8 days before surgery with a dose of 1-1.5 mg/kg of body weight of thymostimulin directly into the uterine cervix. 4 women with cervical and endometrial cancer (stages I and II) and treated with the same doses of physiological saline solution were used as controls. The quantitative results show that in the lymph nodes of women treated with thymostimulin there is a statistically significant marked increase (P less than 0.001), of the paracortical areas.
Cappello
F
F
Center for the Study of and Fight against Tumours, General Hospital, Vicenza, Italy.
Pomari
R
R
Gilboa
G
G
Santopietro
R
R
Corradi
G
G
D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D013949:Thymus Extracts / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery
D013949:Thymus Extracts; C031407:thymostimulin