Protein composition in resting and activated platelets of type I diabetic patients.
Protein composition of platelets of eleven type I diabetic patients and thirteen control subjects were analyzed by SDS polyacrylamide gel electrophoresis. Bands have been scanned and quantified. No significant difference was shown between controls and patients in any of the bands identified in electrophoretic patterns of whole platelet, membrane fraction, resting, activated and aggregated cytoskeleton. Data suggest that alterations observed in platelet function of diabetic patients cannot be connected to the changes in protein composition.
Maresca
M
M
Istituto Policattedra di Chimica Biologica, Università di Genova, Italy.
Buzzi
E
E
Piana
A
A
Armani
U
U
Leoncini
G
G
D001792:Blood Platelets / Q000032:analysis* / Q000502:physiology; D001798:Blood Proteins / Q000032:analysis*; D002462:Cell Membrane / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008565:Membrane Proteins / Q000097:blood; D008970:Molecular Weight; D015539:Platelet Activation; D012016:Reference Values; D013917:Thrombin / Q000502:physiology
D001798:Blood Proteins; D008565:Membrane Proteins; D013917:Thrombin