[Pathologic effect of lipid-lowering and vessel-softening medication in adult and aged rats].
The Wistar's male rats of six months and fifteen months of age were divided randomly into three groups: the Lipid-lowering and Vessel-softening medication (LVM) group, the vitamin E group and the control group. The rat aorta in morphology was observed to study the effects of these medication. The results showed that in the LVM group, the thickening of aorta intima with age was postponed, the thickening ratio of intima to tunica media was reduced, the reduction of smooth muscle cells was inhibited, while the synthesis of collagen fibril and the formation of plaque were also inhibited and the perfection of artery intima was protected.
Ruan
S Y
SY
Wang
X M
XM
D000375:Aging / Q000187:drug effects*; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000648:ultrastructure; D001161:Arteriosclerosis / Q000517:prevention & control; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004365:Drugs, Chinese Herbal