[Effect of vaginal antibiotics suppository on retroperitoneal-space infection after hysterectomy and lymphadenectomy for uterine cancer].
Effects of vaginal antibiotics suppository on the retroperitoneal-space infection were studied in 42 patients who had hysterectomy and lymphadenectomy with diagnosis of uterine cancer stage I or II. All patients received intravenous administration of 1 g LMOX (3 times/day) for 7 days after operation. One group of patients (21 cases) received 0.5 g of ABPC vaginal suppository (twice/day) for 10 days immediately after operation. Another group of 21 patients did not received vaginal suppository. The LMOX concentrations in the exudate decreased rapidly from the 3rd day to the 7th day. The frequencies of bacterial appearance in the retroperitoneal-space in the vaginal suppository group were 33% on 5th day, 33% on 7th day and 20% on 9th day, while those in the control group were 100%, 100% and 76%, respectively. It was concluded that the administration of vaginal antibiotics suppository was easy to handle and effective for preventing the retroperitoneal-space infection after hysterectomy and lymphadenectomy.
Yakabe
A
A
Sugino
N
N
Hayashi
K
K
Yamashita
S
S
Ito
T
T
Takasaki
A
A
D000667:Ampicillin / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D005260:Female; D005831:Genital Diseases, Female / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D008197:Lymph Node Excision / Q000009:adverse effects*; D011183:Postoperative Complications / Q000517:prevention & control; D012187:Retroperitoneal Space; D013488:Suppositories; D014594:Uterine Neoplasms / Q000601:surgery*; D014621:Vagina
D000900:Anti-Bacterial Agents; D013488:Suppositories; D000667:Ampicillin