title: Information theory and the analysis of ligand-binding data.
abstract: The phenomenological principles of information theory are used in the analysis of ligand-binding phenomena in biological macromolecules. Information maps are constructed to visualize regions of ligand chemical potential with maximum amount of information and to devise suitable experimental strategies therefrom. Extensive simulation studies and analysis of experimental data also point out the properties of information used as a weighting procedure in nonlinear least-squares analyses.
authors.affiliation: Istituto di Fisica, Università Cattolica, Roma, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Di Cera
authors.forename: F A
authors.initials: FA
authors.lastname: Bassi
authors.forename: S J
authors.initials: SJ
authors.lastname: Gill
mesh_terms: D002248:Carbon Monoxide / Q000378:metabolism; D006441:Hemoglobin A / Q000378:metabolism; D007257:Information Theory; D016018:Least-Squares Analysis; D008024:Ligands; D046911:Macromolecular Substances; D008433:Mathematics; D010100:Oxygen / Q000378:metabolism; D013816:Thermodynamics
chemical_list: D008024:Ligands; D046911:Macromolecular Substances; D002248:Carbon Monoxide; D006441:Hemoglobin A; D010100:Oxygen