The interaction between ethanol and amiodarone, in the model of adrenaline arrhythmia in the rat.
The antiarrhythmic activity of amiodarone was studied in the model of adrenaline-induced arrhythmia in rats non-dependent and dependent on ethanol. After single or repeated joint administration of ethanol and amiodarone the antiarrhythmic effect of amiodarone was attenuated. No significant differences in the activity of amiodarone were observed when the drug was administered in the period of abstinence.
Filipek
B
B
Department of Pharmacodynamics, Medical Academy, Kraków, Poland.
Krupińska
J
J
Librowski
T
T
Piekoszewski
W
W
D000638:Amiodarone / Q000494:pharmacology*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D004562:Electrocardiography; D004837:Epinephrine; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol; D000638:Amiodarone; D004837:Epinephrine