title: Studies on hypolipidemic agents. IV. 3-[4-(Phenylthio)benzoyl]propionic acid derivatives.
abstract: 2-Acetylthio-3-benzoylpropionic acid derivatives having two benzene rings or condensed-ring moieties were prepared, and tested for hypolipidemic activity in normal rats. Some of these compounds were active. 2-Acetylthio-3-[4-(phenylthio)benzoyl]propionic acid (10) and its derivatives seemed to have the most potent hypocholesterolemic activities. Compound 10 showed strong activity, especially in cholesterol-fed rats.
authors.forename: K
authors.initials: K
authors.lastname: Kameo
authors.forename: Y
authors.initials: Y
authors.lastname: Asami
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
authors.forename: T
authors.initials: T
authors.lastname: Matsunaga
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Tomisawa
authors.forename: K
authors.initials: K
authors.lastname: Sota
mesh_terms: D000818:Animals; D001565:Benzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D008297:Male; D051381:Rats; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D001565:Benzoates; D000960:Hypolipidemic Agents; D013438:Sulfhydryl Compounds