[The role of dopamine in regulating the cerebral circulation in extreme conditions].
In acute experiments on anesthetized cats, the perfusion of dopamine (100 micrograms/kg.min) during 35 minutes after cerebral ischemia inhibited the development of postischemic phenomena. Dopamine was found to exert a considerable effect on the oxidative metabolism in the brain. The responses of cerebral, peripheral vessels and systemic arterial pressure to dopamine (25 and 75 micrograms/kg) in conditions of blood autoperfusion with cooled blood did not differ significantly from those in normothermia. The problem of dopamine participation in the organism adaptive responses to extreme conditions, is discussed.
Pchelintseva
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TR
Pogorelyĭ
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Gaevyĭ
M D
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D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002545:Brain Ischemia / Q000503:physiopathology; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D003080:Cold Temperature / Q000009:adverse effects; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D010477:Perfusion / Q000379:methods; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
D005947:Glucose; D004298:Dopamine
Rol' dofamina v reguliatsii mozgovogo krovoobrashcheniia pri nekotorykh ékstremal'nykh sostoianiiakh.