Acute changes in the bladder reservoir function after irradiation alone or in combination with chemotherapy: a matter of mouse strain.
The acute change in bladder reservoir function was investigated in two different strains of mice [C3H/HaA and C3D2F1 (C3H/Tif x DBA/2)] to elucidate strain dependent differences in response. Both groups were investigated by repeated bladder fillings over a period of 30 days after various treatments. The end point was a 50% reduction in bladder volume at an intravesical pressure of 20 mmHg. Treatment consisted of irradiation alone, chemotherapy alone [Cyclophosphamide (CTX) or Cis-diamminedichloroplatinum (II) (Cis-DDP)] or irradiation in combination with either drug. A significant difference in response between the two strains of mice was noted in the groups treated with CTX alone, irradiation alone and a combination of Cis-DDP plus irradiation. The importance of a strain-dependent response in experimental assays is emphasized.
Lundbeck
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F
Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus C.
Stewart
F A
FA
D000818:Animals; D002945:Cisplatin / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology*; D001743:Urinary Bladder / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects
D003520:Cyclophosphamide; D002945:Cisplatin