Hemopoietic features of splenectomized mice bearing IL-3 producing T cell leukemia.
Hemopoietic responses were studied in splenectomized mice after transplantation of the hemopoietic colony stimulating activity producing leukemia, L8313. In non-splenectomized mice, the number of peripheral leukocytes was elevated to 4 x 10(5)/mm3 after transplantation. In contrast, it was below 1.7 x 10(4)/mm3 in splenectomized mice. Total cell, hemopoietic stem cell and progenitor cell numbers in the bone marrow decreased in both groups. Serum from splenectomized mice contained multi-colony stimulating activity although less effective than that from non-splenectomized mice. Extramedullary hemopoiesis was observed in splenectomized mice. These results suggest that invasion of leukemic cells to bone marrow results in a damage of hemopoietic microenvironment.
Sawada
H
H
Medical Research Council Radiobiology Unit, Chilton, Didcot, Oxon, U.K.
Sugimoto
K
K
Aramaki
K
K
Mori
K J
KJ
D000818:Animals; D003115:Colony-Stimulating Factors / Q000096:biosynthesis; D006410:Hematopoiesis; D007377:Interleukin-3 / Q000096:biosynthesis*; D015458:Leukemia, T-Cell / Q000097:blood*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D013156:Splenectomy
D003115:Colony-Stimulating Factors; D007377:Interleukin-3