[Study on carcinogenic activity of several nickel compounds in mice].
This paper reports the result of the tumor in site induced by several nickel compounds in mice. Three nickel compounds (Ni3S2, NiCl, pure nickel powder) were injected separately to the right arm pit subcutaneously (5 mg/mouse). At the end of the 62nd week, the tested mice were sacrificed. Only nickel sulfide induced tumors in the site of injection, the incidence of tumor was 36%. The majority of the tumors were fibrosarcomas, only 2 rhabdomyosarcomas. The tumors might infiltrate into the surrounding tissues, a few metastasized to the liver and/or the lungs.
Wang
C J
CJ
Jiang
J H
JH
Li
Y Q
YQ
Deng
S L
SL
Luo
D Y
DY
Xiao
H Y
HY
D000818:Animals; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced*; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009532:Nickel / Q000633:toxicity*
C022838:nickel chloride; D009532:Nickel; C017558:nickel sulfide