[Karyotype study of blood lymphocytes in sarcoidosis].
Among 31 patients presenting with pulmonary sarcoidosis, two had abnormalities of their blood lymphocyte karyotypes. The karyotype of the first patient showed an initially high percentage of non-specifically broken chromosomes. The second patient, who had been treated with azathioprine (AZ) one year previously, had an apparently balanced translocation 46 XX, t (11; 11) (p 12, p 14) in blood T lymphocytes but not in skin fibroblast culture. Various hypotheses can be discussed to explain this translocation: a direct toxic effect of AZ or a genomic abnormality depending upon sarcoidosis and possibly revealed by AZ. It is important to note that this translocation concerned a region of the short arm of chromosome 11, where Harvey ras I and parathormone genes have been located.
Pacheco
Y
Y
Service du Pr M. Perrin-Fayolle, Centre hospitalier Lyon-Sud, Pierre-Bénite.
Charrin
C
C
Villa
L
L
Cozon
G
G
Gormand
F
F
Piperno
D
D
Biot
N
N
Harf
R
R
Gindre
D
D
Perrin-Fayolle
M
M
D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005796:Genes / Q000187:drug effects; D006801:Humans; D007621:Karyotyping; D008171:Lung Diseases / Q000097:blood* / Q000188:drug therapy / Q000235:genetics; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000097:blood* / Q000188:drug therapy / Q000235:genetics
D001379:Azathioprine
Etude caryotypique des lymphocytes sanguins dans la sarcoïdose.