Risk factor interactions for coronary heart disease.
There is now an increasing awareness of the atherogenicity of the individual lipoprotein subfractions. In addition, the effects of commonly used antihypertensive drugs has been a cause for concern. Thiazides and loop diuretics both increase LDL cholesterol, but indapamide and spironolactone have no apparent effects. Beta-blocker monotherapy may also increase triglycerides whilst post-synaptic alpha-blockers do not affect, or slightly lower triglycerides, total cholesterol, LDL and VLDL levels.
Mordasini
R C
RC
Institute of Protein Research, University of Berne, Switzerland.
D000959:Antihypertensive Agents / Q000009:adverse effects; D001053:Apolipoproteins / Q000502:physiology; D003327:Coronary Disease / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D008074:Lipoproteins / Q000502:physiology; D008075:Lipoproteins, HDL / Q000502:physiology; D011973:Receptors, LDL / Q000378:metabolism; D012307:Risk Factors
D000959:Antihypertensive Agents; D001053:Apolipoproteins; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D011973:Receptors, LDL