title: Gamete intrafallopian transfer vs superovulation with intrauterine insemination for the treatment of infertility.
abstract: Superovulation with intrauterine insemination (SO-IUI) has been suggested as an alternative to gamete intrafallopian transfer (GIFT), despite the absence of controlled or comparative trials. We retrospectively analyzed all GIFT and SO-IUI cycles performed concurrently from January 1985 to August of 1987 at a single university center. Pregnancy rates were significantly better for GIFT than SO-IUI (P less than 0.001), with an odds ratio of 3.25 (P = 0.001). Stepwise multiple logistic regression identified factors that correlate with pregnancy: absence of endometriosis (P = 0.05), infertility less than 3 years' duration (P = 0.002), TMS greater than or equal to 30 X 10(6) (P = 0.005), and treatment with GIFT rather than SO-IUI (P = 0.001). These data give a first approximation of the increased efficacy of GIFT versus SO-IUI and provide valuable insight into significant confounding variables to be considered when planning a randomized, prospective trial to evaluate these techniques.
authors.affiliation: Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio 78284.
authors.forename: C R
authors.initials: CR
authors.lastname: Kaplan
authors.forename: D L
authors.initials: DL
authors.lastname: Olive
authors.forename: V
authors.initials: V
authors.lastname: Sabella
authors.forename: R H
authors.initials: RH
authors.lastname: Asch
authors.forename: J P
authors.initials: JP
authors.lastname: Balmaceda
authors.forename: R M
authors.initials: RM
authors.lastname: Riehl
authors.forename: T R
authors.initials: TR
authors.lastname: Groff
authors.forename: W N
authors.initials: WN
authors.lastname: Burns
authors.forename: R S
authors.initials: RS
authors.lastname: Schenken
mesh_terms: D000328:Adult; D005260:Female; D015181:Gamete Intrafallopian Transfer / Q000706:statistics & numerical data; D006801:Humans; D007246:Infertility / Q000628:therapy*; D007315:Insemination, Artificial / Q000706:statistics & numerical data; D010060:Ovulation; D011247:Pregnancy; D012044:Regression Analysis; D012189:Retrospective Studies; D013480:Superovulation