title: Displacement chromatography on cyclodextrin-silicas. II. Separation of cis-trans isomers in the reversed-phase mode on alpha-cyclodextrin-silica.
abstract: The feasibility of preparative separations of cis-trans isomers by displacement chromatography on analytical-scale alpha-cyclodextrin-silica columns operated in the reversed-phase mode is demonstrated by using the isomers of 3-hexen-1-ol as model substrates and n-alkanols as displacers. The importance of matching the size of the cyclodextrin cavity and the solutes is shown. The crucial role of the displacer (both type and concentration) in the success of the displacement chromatographic separation is demonstrated.
authors.affiliation: Department of Chemistry, Texas A & M University, College Station 77843.
authors.forename: G
authors.initials: G
authors.lastname: Vigh
authors.forename: G
authors.initials: G
authors.lastname: Farkas
authors.forename: G
authors.initials: G
authors.lastname: Quintero
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D003505:Cyclodextrins; D007536:Isomerism; D012031:Refractometry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D003505:Cyclodextrins