title: [Combination effect of photodynamic therapy and microwave hyperthermia on experimental squamous cell carcinoma in vivo].
abstract: We investigated the time course of Hematoporphyrin oligomer (HpO) uptake to squamous cell carcinoma (SCC) transplanted into C3H mice after intraperitoneal (i.p.)-injection by measuring its fluorescence intensity. The fluorescence intensity was maximum at 83 hr after the i.p.-injection. The tumors once disappeared by the single application of photodynamic therapy (PDT) or microwave hyperthermia at 83 hr after HpO i.p.-injection. However, all the tumors treated with these single modalities recurred within 4 weeks after the treatments. Therefore, we investigated the therapeutic effect of microwave hyperthermia in combination with PDT at 83 hr after HpO i.p.-injection. As the results, the combination effect was the strongest when high-dose therapy was used as the first choice of therapy, irrespective of the orders of the treatments and no tumor regrowth occurred over 45 days after tumor disappearance.
authors.forename: N
authors.initials: N
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: N
authors.initials: N
authors.lastname: Miyoshi
authors.forename: K
authors.initials: K
authors.lastname: Nakanishi
authors.forename: M
authors.initials: M
authors.lastname: Fukuda
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D006414:Hematoporphyrin Photoradiation; D006415:Hematoporphyrins / Q000493:pharmacokinetics; D006979:Hyperthermia, Induced / Q000379:methods; D051379:Mice; D008809:Mice, Inbred C3H; D008872:Microwaves / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D010778:Photochemotherapy
chemical_list: D006415:Hematoporphyrins