title: [Carcinogenic activity of nickel-containing welding aerosols in relation to their copper and manganese content].
abstract: Chronic experiments on animals showed that aerosols formed during cast iron welding and facing due to the use of electrode nickel-based materials could produce blastomogenic effect that was mostly caused by the presence of copper-and manganese-containing aerosols in the particles of the solid component. Morphologic inhomogeneity of the particles of the solid component, qualitative composition and solubility of the compounds spatially arranged in the surface layer were of great importance for their carcinogenic and toxic effect. The capacity of copper- and manganese-containing compounds to suppress nickel carcinogenic effect should be taken into account when developing welding and facing materials with better hygienic characteristics.
authors.forename: L N
authors.initials: LN
authors.lastname: Gorba'n
authors.forename: N L
authors.initials: NL
authors.lastname: Novichenko
authors.forename: A V
authors.initials: AV
authors.lastname: Riazanov
authors.forename: V M
authors.initials: VM
authors.lastname: Cherednichenko
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D003043:Cocarcinogenesis; D003300:Copper / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D008297:Male; D008345:Manganese / Q000008:administration & dosage; D020149:Manganese Poisoning; D051379:Mice; D008808:Mice, Inbred CBA; D009532:Nickel / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D051381:Rats; D014896:Welding
chemical_list: D000393:Air Pollutants; D008345:Manganese; D003300:Copper; D009532:Nickel
vernacular_title: O sviazi kantserogennoĭ aktivnosti nike'lsoderzhashchikh svarochnykh aérozoleĭ s nalichiem v ikh sostave soedineniĭ medi i magrantsa.