title: Hepatitis B virus infection in lepromatous and tuberculoid patients from Senegal.
abstract: Hepatitis B Virus (HBV) seric markers (HBs Ag, anti-HBs, and HBe Ag) were studied in 987 Senegalese leprosy patients (lepromatous: LL; tuberculoid: TT) in comparison with 6187 healthy adults (controls). Two populations of leprosy patients from ILAD (Institut de Léprologie Appliquée de Dakar) were studied: The First study (i.e.: study I) between 1973 and 1977 included 553 patients (329 LL; 224 TT). The Second study (i.e.: study II) between 1982 and 1986 included 434 patients (236 LL; 198 TT). HBV serological markers were tested by various techniques. By RIA, they were present in 98% and 96.5% in the studies I and II respectively. Each marker was studied and compared to the control population. HBs Ag detected by RIA was present in 25.5% (study I) and 23.0% (study II) when comparing to 15.2% in the control group. This marker was correlated with leprosy forms (LL and TT), age, sex, ethnic group.
authors.affiliation: Laboratoire de microbiologie immunologie, Faculté des sciences pharmaceutiques de Tours, France.
authors.forename: B
authors.initials: B
authors.lastname: Yvonnet
authors.forename: P
authors.initials: P
authors.lastname: Vincelot
authors.forename: J
authors.initials: J
authors.lastname: Millan
authors.forename: G
authors.initials: G
authors.lastname: Lesage
authors.forename: F
authors.initials: F
authors.lastname: Denis
authors.forename: J
authors.initials: J
authors.lastname: Languillon
authors.forename: S
authors.initials: S
authors.lastname: Mboup
authors.forename: P
authors.initials: P
authors.lastname: Coursaget
authors.forename: I
authors.initials: I
authors.lastname: Diop Mar
authors.forename: J P
authors.initials: JP
authors.lastname: Chiron
mesh_terms: D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000150:complications*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006513:Hepatitis B e Antigens / Q000032:analysis; D006801:Humans; D015440:Leprosy, Lepromatous / Q000097:blood / Q000150:complications*; D015441:Leprosy, Tuberculoid / Q000097:blood / Q000150:complications*; D008297:Male; D012675:Senegal
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens