title: Carotid body amine levels in goats exposed to hypoxia or hypercapnia.
abstract: The carotid body (CB) contains large amounts of several monoamines. There is considerable evidence that carotid body (CB) chemoreceptor function may be regulated by one or several of these monoamines. In order to test whether conditions stimulating the CB might change the CB content of these monoamines, we measured the norepinephrine, dopamine, 5-hydroxyindoleacetic acid, and 5-hydroxytryptamine content of carotid bodies collected from goats exposed to 4 h of either normoxic-normocapnic, hypoxic-normocapnic, or normoxic-hypercapnic gas mixtures. We found that there were no consistent changes in the levels of these amines associated with exposure to the test gases. These findings would not support the hypothesis that changes in these amine levels in the CB are responsible for the time-dependent changes in carotid chemoreceptor activity in goats exposed to 4 h of hypoxia.
authors.affiliation: Department of Comparative Biosciences, University of Wisconsin, Madison 53706.
authors.forename: M J
authors.initials: MJ
authors.lastname: Engwall
authors.forename: E B
authors.initials: EB
authors.lastname: Olson
authors.forename: G E
authors.initials: GE
authors.lastname: Bisgard
mesh_terms: D000818:Animals; D002344:Carotid Body / Q000378:metabolism* / Q000503:physiopathology; D002395:Catecholamines / Q000378:metabolism*; D005260:Female; D006041:Goats / Q000378:metabolism / Q000502:physiology*; D006935:Hypercapnia / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D012701:Serotonin / Q000378:metabolism*
chemical_list: D002395:Catecholamines; D012701:Serotonin