title: [Stabilization of antiviral activity of porcine leukocytic interferon].
abstract: Unithiol (2,3-dimercaptopropan-sodium sulphonate) has been found to be an effective, nontoxic stabilizer of antiviral activity of labile interferons. The optimum stabilizing concentration of unithiol is 0.07%: at this concentration its protective effect is maximum with the lowest content of the substance. Unithiol at this concentration retains about 66% of the initial antiviral activity in acid medium (pH 2.0) and up to 75% of the initial antiviral activity on mechanical exposure.
authors.forename: I I
authors.initials: II
authors.lastname: Georgadze
authors.forename: N Sh
authors.initials: NSh
authors.lastname: Chigogidze
authors.forename: N V
authors.initials: NV
authors.lastname: Topuriia
authors.forename: Z Kh
authors.initials: ZKh
authors.lastname: Khasenova
authors.forename: I L
authors.initials: IL
authors.lastname: Bukhnikashvili
mesh_terms: D000818:Animals; D000998:Antiviral Agents; D002460:Cell Line; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007370:Interferon Type I / Q000494:pharmacology*; D013314:Stress, Mechanical; D013552:Swine; D014494:Unithiol
chemical_list: D000998:Antiviral Agents; D007370:Interferon Type I; D014494:Unithiol
vernacular_title: Stabilizatsiia protivovirusnoĭ aktivnosti svinogo leĭkotsitarnogo interferona.