[The cellular sensitivity of the primary tumor and its metastases in breast cancer patients to cytostatics, interferon and tumor necrosis factor].
Samples of tumor tissue obtained from 47 patients with primary and metastatic breast cancer were implanted under the renal capsule of mice (SRCA-test) to assess individual sensitivity of these malignancies to cytostatics, recombinant interferon (rIFN) and--in some cases--to tumor necrosis factor (TNF). Primary tumor was shown to respond to cytostatics and rIFN in as few as 33.3 and 26.7% of cases, respectively. Xenografts of metastases displayed higher rates of response to all the drugs studied, viz. 64.2, 86.7 and 90% for cytostatics, rIFN and TNF, respectively.
Vorontsova
A L
AL
Garina
G B
GB
Kudriavets
Iu I
IuI
Ponomarev
I N
IN
Korolev
V I
VI
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008207:Lymphatic Metastasis; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D011994:Recombinant Proteins; D013370:Subrenal Capsule Assay; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D007370:Interferon Type I; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha
Issledovanie chuvstvitel'nosti kletok pervichnoĭ opukholi i metastazov u bol'nykh rakom molochnoĭ zhelezy k tsitostatikam, interferonu i faktoru nekroza opukholeĭ.