Collagen corneal shields enhance penetration of topical prednisolone acetate.
We used an animal model to compare the corneal and aqueous penetration of topical prednisolone acetate 1% with and without the presence of a commercially available collagen corneal shield. A significant (P less than .02) increase in penetration into cornea and aqueous humor at 30 minutes and 120 minutes was found in eyes with a collagen corneal shield in place. Increased concentrations were achieved by soaking the shield in prednisolone acetate for 15 minutes prior to application.
Sawusch
M R
MR
Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, Maryland.
O'Brien
T P
TP
Updegraff
S A
SA
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism; D001458:Bandages; D001684:Biological Dressings; D003094:Collagen / Q000627:therapeutic use*; D003315:Cornea / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D011239:Prednisolone; D011817:Rabbits
D000893:Anti-Inflammatory Agents; D003094:Collagen; D011239:Prednisolone