Biochemical and genetic studies on rabbit hemoglobin. I. Electrophoretic polymorphism of the beta chain.
A genetic polymorphism of beta-chain rabbit (Oryctolagus cuniculus) hemoglobin is demonstrated by means of acid starch gel electrophoresis. The biochemical evidence presented suggests that a previously reported substitution of a neutral amino acid for a histidine is responsible for the detected genetic variation. Segregation analysis was performed in a sample of 15 matings with 49 offspring and confirmed the genetic hypothesis: two common alleles at an autosomal locus. The calculated gene frequencies in a random sample of 125 individuals are HBB*1 = 0.48 and HBB*2 = 0.52.
Ferrand
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Instituto de Zoologia, Faculdade de Ciências, Universidade do Porto, Portugal.
D000483:Alleles; D000818:Animals; D004586:Electrophoresis; D005787:Gene Frequency; D006454:Hemoglobins / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D011174:Portugal; D011487:Protein Conformation; D011817:Rabbits; D011897:Random Allocation
D006454:Hemoglobins