High concentrations of 2-5A, the interferon intracellular mediator, in the blood of children with acute viral infections.
We measured the concentration of 2-5A (2',5'-oligoadenylate), an intracellular mediator of the antiviral action of interferon, in the blood of children with acute viral and bacterial infectious diseases. 2-5A concentration was found to be elevated in several children with viral diseases. This elevation seemed transient and was not specific for viral infections. We provide arguments for the use of 2-5A as a marker of the evolution of diagnosed viral diseases.
Luxembourg
A
A
Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France.
Laurence
L
L
Tardieu
M
M
Garnier
J M
JM
Dussaix
E
E
Cailla
H
H
D000208:Acute Disease; D000227:Adenine Nucleotides / Q000097:blood*; D000293:Adolescent; D001424:Bacterial Infections / Q000097:blood / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007223:Infant; D008457:Measles / Q000097:blood* / Q000175:diagnosis; D008587:Meningitis, Viral / Q000097:blood* / Q000175:diagnosis; D008590:Meningoencephalitis / Q000097:blood* / Q000175:diagnosis; D009843:Oligoribonucleotides / Q000097:blood*; D011379:Prognosis; D011500:Protein Synthesis Inhibitors / Q000097:blood; D014777:Virus Diseases / Q000097:blood* / Q000175:diagnosis
D000227:Adenine Nucleotides; D009843:Oligoribonucleotides; D011500:Protein Synthesis Inhibitors; C023505:2',5'-oligoadenylate