[Zinc and parlodel: the treatment potentials for retardation of growth and sexual development in nephropathies in adolescents].
Ten adolescents aged 10-18 years with physical and/or sexual development retardation associated with nephropathy were examined. Eight patients were treated with immunodepressants before and/or at the moment of examination. The difference between the age indicated in the patient's passport and bone age ranged within 0 to 3 years. On spermogram examination 3 of 4 patients manifested pathospermia. The serum prolactin level and the level of gonadotropins appeared normal but the testosterone content and plasma zinc level were lowered. As a result of the treatment with parlodel and/or zinc acetate for 1.5 to 23 months, 9 of 10 patients demonstrated the rise of the height and body weight and developed secondary sexual signs. In 3 of 4 patients examined for that parameter, the spermograms improved. In the whole group, the concentration of blood prolactin decreased, that of testosterone and zinc rose, whereas the content of gonadotropins remained unchanged.
Kukhtevich
A V
AV
Ermolenko
V M
VM
Bunatian
A F
AF
Gitel'
E P
EP
Smirnova
G A
GA
D000293:Adolescent; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001971:Bromocriptine / Q000627:therapeutic use*; D002648:Child; D012734:Disorders of Sex Development / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D004341:Drug Evaluation; D006130:Growth Disorders / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006728:Hormones / Q000097:blood; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000150:complications*; D008297:Male; D012741:Sexual Maturation / Q000187:drug effects; D013076:Sperm Count / Q000187:drug effects; D015032:Zinc / Q000097:blood / Q000627:therapeutic use*
D006728:Hormones; D001971:Bromocriptine; D015032:Zinc
Tsink i parlodel: vozmozhnosti lecheniia zaderzhki rosta i polovogo razvitiia pri nefropatiiakh u podrostkov.