[Effect of verapamil on hepatorenal toxicity induced by cyclosporin].
The immunosuppressive and nephrotoxic effects of cyclosporine A (CsA) have been ascribed to a calcium-dependent mechanism of action. However, verapamil, a slow-calcium-channel blocking agent, enhances the immunosuppressive action of CsA and reduces its nephrotoxicity. The present experimental study performed in Wistar rats demonstrates that 0.1 mg..24 h.-1 IM verapamil prevents reduction of liver weight caused by treatment with 20 mg..kg.-1..24 h.-1 IM, as well as a rise in SGOT, SGPT, serum LDH and creatinine. The nephro-protective effects of verapamil in rats treated with CsA could be ascribable to the increased plasma clearance of the immunosuppressive agent.
Aller Reyero
M A
MA
Arias Pérez
J
J
Lorente Ruigómez
L
L
Arias Fernández
L
L
Trovo Muñiz
J I
JI
Brandau Ballnet
D
D
Durán Sacristán
H
H
D000818:Animals; D003524:Cyclosporins / Q000633:toxicity*; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000494:pharmacology*
D003524:Cyclosporins; D014700:Verapamil
Efecto de verapamil sobre la toxicidad hepatorrenal inducida por ciclosporina.