A simple conversion of artemisinic acid into artemisinin.
Artemisinic acid [1] has been converted into artemisinin [3] in 2 steps via reduction of the exocyclic methylene group and photooxidation of the resulting dihydroartemisinic acid [2].
Roth
R J
RJ
Department of Chemistry, George Mason University, Fairfax, Virginia 22030.
Acton
N
N
D000962:Antimalarials / Q000138:chemical synthesis*; D037621:Artemisinins; D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012717:Sesquiterpenes / Q000138:chemical synthesis*; D013696:Temperature
D000962:Antimalarials; D037621:Artemisinins; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C031327:artemisinin