Idiotypic network in myasthenia gravis.
Fluctuations in idiotypic and anti-idiotypic Ab levels over time in two myasthenia gravis patients were found to vary either inversely with one another or in relation to one another. A pair of 46-year-old female twins in which one of the twins developed myasthenia gravis while the other remained healthy were also studied. Ab specificities and immunoglobulin specificities available in the B cell repertoire were found to be similar in both twins.
Eng
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Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Lefvert
A K
AK
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000378:metabolism; D001323:Autoantibodies / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000378:metabolism*; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D007130:Immunoglobulin Idiotypes