Inhibitory effects of Santolina chamaecyparissus extracts against spasmogen agonists.
Several extracts of Santolina chamaecyparissus ssp. squarrosa antagonized in a concentration-dependent way the contractions of rat duodenum, guinea-pig ileum, rat vas deferens and rat uterus as induced by acetylcholine, histamine, noradrenaline, oxytocin and serotonin. Polar extracts were less active than apolar extracts, and it was necessary to assay the former at higher concentrations. Only the lyophilized aqueous extract produced a slight hypotensive effect when given intravenously at 150 mg/kg to urethananesthetized rats.
Giner
R M
RM
Departamento de Farmacologia y Farmacotecnia, Facultad de Farmacia, Universitat de Valencia, Spain.
Ríos
J L
JL
Villar
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004386:Duodenum / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010276:Parasympatholytics; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013030:Spain; D014590:Uterine Contraction / Q000187:drug effects
D010276:Parasympatholytics; D010936:Plant Extracts