Pharmacological study of certain extracts of Laurobasidium lauri.
On the basis of observational screening in conscious rats, the essential oil of Laurobasidium lauri seems to be the main agent responsible for the sedating and analgesic effects of this fungus. The inhibitory activity observed in isolated rat uterus with the butanol and alkaloid-rich fractions of this species appears to be related to a decrease in the calcium available for contraction.
Martin
M L
ML
Department of Physiology and Pharmacology, Faculty of Pharmacy, University of Salamanca, Spain.
Sagredo
J A
JA
Morais
J
J
Sánchez
M T
MT
Sevilla
M A
MA
San Roman
L
L
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001487:Basidiomycota / Q000032:analysis*; D002122:Calcium Chloride / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009822:Oils, Volatile / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D013030:Spain; D014590:Uterine Contraction / Q000187:drug effects
D009822:Oils, Volatile; D012701:Serotonin; D010121:Oxytocin; D002122:Calcium Chloride; D000109:Acetylcholine; D011188:Potassium