[Chronobiological analysis of thyroxine action on cell proliferation in the hypotetraploid strain of Ehrlich's ascitic tumor].
Experiments on white random-bred male mice were made to study the effect of L-thyroxine on cell proliferation of the hypotetraploid strain of Ehrlich's ascites carcinoma. It was shown that prolonged thyroxine administration (during 6 days of carcinoma growth) lead to synchronization of cell proliferation and the maximum values of the mitotic index was found 3 hours earlier then in the control experiments. At the same time thyroxine did not exert any noticeable effect on the average daily magnitudes of the number of DNA-synthesizing cells and did not change the pattern of modulations in the radioactive index. The changes in the mitotic index and radioactive index were asynchronous in control and experimental animals. Analogous results were found for hyperdiploid strain of Ehrlich's ascites tumor. Ploidy of cells did not influence the tipe rhythms of the cell proliferation and its reaction on the action of thyroxine.
Romanov
Iu A
IuA
Stepanenko
V A
VA
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D002455:Cell Division / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008940:Mitotic Index; D011003:Ploidies; D013974:Thyroxine / Q000494:pharmacology*; D013997:Time Factors
D004273:DNA, Neoplasm; D013974:Thyroxine
Khronobiologicheskiĭ analiz deĭstviia tiroksina na kletochnuiu proliferatsiiu v gipotetraploidnom shtamme astsitnoĭ opukholi Erlikha.