Effect of calcium dobesilate on the inhibition of collagen fibrillogenesis by glucose in vitro.
Glucose inhibits collagen fibril formation as shown in an in vitro system using thermal fibrillogenesis of collagen type I and type II solutions containing different concentrations of glucose. Studies of the time course and extent of fibril formation indicate that glucose values similar to subjects with normal glucose metabolism effect no significant difference to the control without glucose, whereas high glucose levels mimicking glucose concentrations of diabetics with poor glucose control, significantly delay collagen fibrillogenesis. By defined concentrations of calcium dobesilate (Doxium) the effect of a pathologically high glucose content of collagen fibril formation can be inversed to parameters similar as observed with glucose concentrations of a subject with normal glucose metabolism.
Schmut
O
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Universitäts-Augenklinik, Graz, Austria.
D000818:Animals; D001557:Benzenesulfonates / Q000494:pharmacology*; D002123:Calcium Dobesilate / Q000494:pharmacology*; D002417:Cattle; D003094:Collagen / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology*
D001557:Benzenesulfonates; D002123:Calcium Dobesilate; D003094:Collagen; D005947:Glucose