title: Efficacy of nemadectin, a new broad-spectrum endectocide, against natural infections of canine gastrointestinal helminths.
abstract: Nemadectin, a new broad-spectrum endectocide, was highly efficacious against natural infections of all the major canine gastrointestinal helminths. At single oral dosages of 0.2-0.4 mg kg-1 body weight (BW), a liquid formulation administered in gelatin capsules was 100% effective in eliminating natural infections of Toxocara canis, Toxascaris leonina, Ancylostoma caninum and Uncinaria stenocephala. Tablets (267 mg) containing 4.6% nemadectin given at a rate of 1/3 tablet per 20 kg BW (0.2 mg nemadectin kg-1) were 100% active against T. canis, A. caninum and U. stenocephala. With both formulations, an increase in the dose rate to 0.6-0.8 mg kg-1 BW resulted in 99-100% elimination of Trichuris vulpis infections. No adverse reactions were observed in any of the treated dogs.
authors.affiliation: American Cyanamid Company, Princeton, NJ 08540.
authors.forename: M E
authors.initials: ME
authors.lastname: Doscher
authors.forename: I B
authors.initials: IB
authors.lastname: Wood
authors.forename: J A
authors.initials: JA
authors.lastname: Pankavich
authors.forename: C A
authors.initials: CA
authors.lastname: Ricks
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002214:Capsules; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D006373:Helminthiasis / Q000188:drug therapy; D006374:Helminthiasis, Animal; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D018942:Macrolides; D013607:Tablets
chemical_list: D000900:Anti-Bacterial Agents; D000969:Antinematodal Agents; D002214:Capsules; D018942:Macrolides; D013607:Tablets; C056041:nemadectin