Multiple risk factor evaluation in a hypertension clinic.
Hypertension is associated with abnormal lipoprotein metabolism, which may be exacerbated by some groups of antihypertensive drugs and represents an additional powerful coronary heart disease risk factor. Of our Hypertension Clinic population, 75% had a total fasting serum cholesterol greater than 5.2 mmol/l. Dietary advice and adjustment of antihypertensive therapy has achieved significant reductions in total cholesterol, serum triglycerides and body weight (14%, 18% and 4.3%, respectively) in a cohort of 65 patients reassessed over a period of 3-21 months. The reduction in cholesterol is likely to represent at least a 28% reduction in the risk of a major coronary heart disease event, even before taking account of any improvement in other coronary heart disease risk factors.
Thom
S
S
Hypertension Clinic, St Mary's Hospital, London, UK.
Bunker
J
J
Callister
W
W
Poulter
N
N
Sever
P
P
Zographos
D
D
D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology* / Q000517:prevention & control; D008131:London / Q000453:epidemiology; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol