Biological N-oxidation of piperidine in vitro.
The biological N-oxidation of piperidine, a pharmacologically active biogenic amine of mammals and human beings, was studied in vitro. After incubation of piperidine-HCl in a fortified rat liver microsomal preparation (9000 x g supernatant) at 37 degrees C for 30 min, 2 metabolites were detected. They were identified as N-hydroxy piperidine and 2, 3, 4, 5-tetrahydro-pyridine-1-oxide as evidenced by TLC, GLC, HPLC, GC-MS and MS.
Wang
D Y
DY
Gorrod
J W
JW
Beckett
A H
AH
D000818:Animals; D001711:Biotransformation; D008862:Microsomes, Liver / Q000378:metabolism; D010880:Piperidines / Q000378:metabolism / Q000493:pharmacokinetics*; D011725:Pyridines / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D010880:Piperidines; D011725:Pyridines; C062320:N-hydroxypiperidine; C043383:1-piperideine