title: Congenital factor XIII deficiency with multiple benign breast tumours and successful pregnancy with substitutive therapy. A case report.
abstract: A 34-year-old woman with congenital factor XIII (FXIII) deficiency and multiple connective tissue tumours is reported. The subunit a of FXIII was totally absent in her plasma, platelets and histiocytes of breast fibroadenomas and considerably reduced in the monocytes (below 5%). The plasmatic level of subunit b was also reduced (25%). She had a bleeding tendency and habitual abortions. Fresh frozen plasma therapy permitted a successful pregnancy.
authors.affiliation: Second Department of Medicine, University Medical School, Debrecen, Hungary.
authors.forename: Z
authors.initials: Z
authors.lastname: Boda
authors.forename: G
authors.initials: G
authors.lastname: Pfliegler
authors.forename: L
authors.initials: L
authors.lastname: Muszbek
authors.forename: A
authors.initials: A
authors.lastname: Tóth
authors.forename: R
authors.initials: R
authors.lastname: Adány
authors.forename: J
authors.initials: J
authors.lastname: Hársfalvi
authors.forename: Z
authors.initials: Z
authors.lastname: Papp
authors.forename: I
authors.initials: I
authors.lastname: Tornai
authors.forename: K
authors.initials: K
authors.lastname: Rak
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000150:complications* / Q000628:therapy; D005260:Female; D006467:Hemophilia A / Q000150:complications* / Q000628:therapy; D006801:Humans; D010949:Plasma; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011252:Pregnancy Complications, Neoplastic