Bf and C4 phenotypes in patients with psoriasis.
Phenotype frequencies for the complement proteins Bf (factor B), C4A and C4B were performed in a sample of 49 Caucasian patients with psoriasis followed in Memphis, Tennessee. The genes for these proteins are located in the major histocompatibility complex between the HLA-B and HLA-DR loci. Bf phenotype frequency did not differ significantly for the patients as compared to regional controls. The C4*A6 allele was present in 26.6% of the patients as compared to 5.4% of the controls, p less than 0.001, relative risk = 4.93. The C4*A6 allele is known to be in linkage disequilibrium with the HLA B17 allele and produces a functionally defective gene product. The role, if any, of C4*A6 in the pathogenesis of psoriasis is uncertain.
Wyatt
R J
RJ
Department of Pediatrics, University of Tennessee, Memphis.
Wang
C
C
Hudson
E C
EC
Jones
R M
RM
Noah
P W
PW
Rosenberg
E W
EW
D003181:Complement C4 / Q000235:genetics*; D011415:Complement Factor B / Q000235:genetics*; D004586:Electrophoresis / Q000379:methods; D004792:Enzyme Precursors / Q000235:genetics*; D006801:Humans; D010641:Phenotype; D011565:Psoriasis / Q000235:genetics*
D003181:Complement C4; D004792:Enzyme Precursors; D011415:Complement Factor B