title: N-(2-mercaptopropionyl)-glycine inhibits chemiluminescence and accelerates phagocytosis in human polymorphonuclear leukocytes.
abstract: Treatment of polymorphonuclear leukocytes with the soluble and cell penetrating thiol N-(2-mercaptopropionyl)-glycine (2-MPG) inhibits luminol-enhanced chemiluminescence induced by opsonized zymosan, which is believed to be a measure for the generation of reactive oxygen species, and accelerates the rate of phagocytosis measured as ingestion of zymosan particles. It is discussed that 2-MPG protects the phagocyting cells from oxidative damage by reactive oxygen species that are formed during particle ingestion.
authors.affiliation: Institute of Pathological Biochemistry, Medical Academy of Erfurt, GDR.
authors.forename: W
authors.initials: W
authors.lastname: Lösche
authors.forename: E
authors.initials: E
authors.lastname: Michel
authors.forename: S
authors.initials: S
authors.lastname: Krause
authors.forename: G P
authors.initials: GP
authors.lastname: Pescarmona
authors.forename: U
authors.initials: U
authors.lastname: Till
mesh_terms: D006801:Humans; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*; D008625:Tiopronin / Q000494:pharmacology*
chemical_list: D008625:Tiopronin