[Preventive and therapeutic effect of estrogen administration in adjuvant arthritis].
Using adjuvant arthritis as a model for human rheumatoid arthritis, we examined prophylactic and therapeutic effects for different doses of estrogen (0.5-5.0 mg estradiol 3x/week) in 40 male Long Evans rats compared to 16 control animals. More than 2.5 mg estradiol resulted in significantly reduced inflammatory activity, both in animals treated before or after induction of arthritis (Mann Whitney U-test, p less than 0.05).
Schlaghecke
R
R
Abteilung für Endokrinologie und Rheumatologie, Universität Düsseldorf.
Lenhardt
E
E
Fortkamp
E
E
Juli
E
E
Zeidler
H
H
D000818:Animals; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains
D004958:Estradiol
Prophylaktischer und therapeutischer Effekt der Ostrogengabe bei der Adjuvans-Arthritis.