title: Possibilities of extending the indications for application of single antibacterial doses in urological practice.
abstract: The authors report very good results of the application of single antibacterial doses in the therapy of acute bacterial cystitis and asymptomatic bacteriuria and point out that in addition to these already established indications, single doses can be applied successfully in some other forms of urinary infection, too. They share the clinical results and on the basis of some experiments maintain the standpoint that postoperative urinary infections are also suitable for this therapy (if no evidence of pyelonephritis is available), as well as the infections of the upper urinary tract (if the isolated microorganisms are not charged with antibodies). A scheme of the so-called "long-term therapy with single dose once a week" is proposed instead of the systematic 3-6 months therapy. The results are compared to the routine 7-10 day course of treatment; as a matter of fact, they are the same. The advantages of the single-dose therapy are discussed.
authors.affiliation: Department of Urology, Emergency Medical Institute, N.I. Pirogov, Sofia, Bulgaria.
authors.forename: N
authors.initials: N
authors.lastname: Minkov
authors.forename: B
authors.initials: B
authors.lastname: Zosikov
authors.forename: Z
authors.initials: Z
authors.lastname: Zlatanov
authors.forename: D
authors.initials: D
authors.lastname: Staneva
authors.forename: M
authors.initials: M
authors.lastname: Lesseva
authors.forename: D
authors.initials: D
authors.lastname: Christova
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy*; D001437:Bacteriuria / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D003556:Cystitis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents