Chemical and pharmacological studies on Talauma ovata St. Hil. (Magnoliaceae).
Antidiabetic activity of crude extract of leaves of Talauma ovata St. Hil. (Magnoliaceae) was analysed as part of a general pharmacological screening of this plant. Chemical analysis demonstrated the presence of phytosteroids, saponins, alkaloids and tannins in the crude extract. Pharmacological studies failed to demonstrate hypoglycemic effect of this plant in normoglycemic, hyperglycemic or alloxan-diabetic rats. The low LD50 obtained for this plant strongly suggests that its consumption by the population may be hazardous.
Morato
G S
GS
Departamentos de Farmacologia e Química, Universidade Federal de Santa Catarina, Florianóplis, Brasil.
Calixto
J B
JB
Cordeiro
L
L
de Lima
T C
TC
Morato
E F
EF
Nicolau
M
M
Rae
G A
GA
Takahashi
R N
RN
Valle
R M
RM
Yunes
R A
RA
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007004:Hypoglycemic Agents; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010277:Parasympathomimetics; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains
D007004:Hypoglycemic Agents; D010277:Parasympathomimetics; D010936:Plant Extracts