title: [In vitro studies of the antitumor effect of melphalan and analogous aniline mustard derivatives].
abstract: Melphalan and analogous aniline mustard derivatives were tested on antitumor activity in vitro. All compounds showed similar antiproliferative effects against melanoma B16, sarcoma 180 and leukemia P388D1. Thus, the singular clinical efficiency of melphalan may not simply be explained by a selective uptake employing amino acid carrier systems of tumor cells.
authors.forename: R
authors.initials: R
authors.lastname: Laske
authors.forename: W
authors.initials: W
authors.lastname: Krischke
authors.forename: U
authors.initials: U
authors.lastname: Loos
mesh_terms: D000816:Aniline Mustard / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents; D008558:Melphalan / Q000494:pharmacology*; D051379:Mice; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D009588:Nitrogen Mustard Compounds; D000816:Aniline Mustard; D008558:Melphalan
vernacular_title: In vitro-Untersuchungen zur tumorhemmenden Wirkung von Melphalan und analogen Anilin-Lost-Derivaten.