title: Natural killer activity and NK cytotoxic factors in peripheral blood and lymph node cells from non-Hodgkin's lymphoma patients.
abstract: Natural killer (NK) activity and natural killer cytotoxic factors (NKCF) were found to be depressed in large granular lymphocytes (LGL) from the peripheral blood and lymph node lymphocytes (LNL) from untreated non-Hodgkin's lymphoma (NHL) patients. The LGL number was also reduced in NHL patients as compared to the normal subjects. The depression in all the activities mentioned above showed a correlation with the clinical status of the patients. Exogenous interferon-alpha (IFN-alpha) treatment of the effector cells could augment the NK activity to a comparable extent in normal as well as patient's LNL. The results indicate that the production of interferon may be affected in cases of NHL and therefore it would be worthwhile to test the tolerance and efficacy of IFN-alpha in these patients.
authors.affiliation: Immunology Division, Tata Memorial Centre, Parel, Bombay, India.
authors.forename: J J
authors.initials: JJ
authors.lastname: Nadkarni
authors.forename: B A
authors.initials: BA
authors.lastname: Mehta
authors.forename: S B
authors.initials: SB
authors.lastname: Koppikar
authors.forename: C S
authors.initials: CS
authors.lastname: Soman
authors.forename: S S
authors.initials: SS
authors.lastname: Shrikhande
authors.forename: S H
authors.initials: SH
authors.lastname: Advani
mesh_terms: D000328:Adult; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D014407:Tumor Cells, Cultured
chemical_list: D007370:Interferon Type I