Anti-Ia antibodies inhibit the spontaneous secretion of IL-1 from silicotic rat alveolar macrophages.
Class II antigens of the major histocompatibility complex (Ia) are important components in the investigation of cell-mediated immune responses. Several reports have indicated that anti-Ia monoclonal antibodies suppress disease development in animal models. In this paper, the expression of Ia and the effect of anti-Ia on IL-1 secretion from alveolar macrophages (AM) from silica-treated rats was examined. The results obtained showed that 45% of silicotic AM, but only 5% of AM from normal control rats, express Ia antigen. Anti-Ia treatment of silicotic AM reduced IL-1 secretion by 55%. We conclude that anti-Ia immune suppression may involve the inhibition of IL-1 secretion.
Struhar
D
D
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO.
Harbeck
R J
RJ
D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism / Q000494:pharmacology; D000949:Histocompatibility Antigens Class II; D007165:Immunosuppression Therapy; D007167:Immunotherapy; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D008297:Male; D011650:Pulmonary Alveoli / Q000276:immunology* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012829:Silicosis / Q000276:immunology* / Q000628:therapy
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II; D007375:Interleukin-1