title: [Synthesis and cardiovascular activities of peptidyl dopamine derivatives].
abstract: Amino acids and small peptides with different steric configurations and lipophilicities were appended to dopamine. Eighteen compounds have been synthesized. The attachment of D-amino acids or N-methyl amino acids onto the dopamine molecule caused a marked decrease in cardiovascular activity by intravenous injection, while the introduction of lipophilic amino acids caused a marked increase in myocardial contractility and blood pressure in anesthetized dogs. The durations of action were also prolonged.
authors.forename: D M
authors.initials: DM
authors.lastname: Gao
authors.forename: F Q
authors.initials: FQ
authors.lastname: Yang
authors.forename: G L
authors.initials: GL
authors.lastname: Chen
authors.forename: W Y
authors.initials: WY
authors.lastname: Cheng
authors.forename: J C
authors.initials: JC
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Min
authors.forename: H M
authors.initials: HM
authors.lastname: Shang
authors.forename: S A
authors.initials: SA
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004298:Dopamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D010455:Peptides; D004298:Dopamine