Factor released from human lymphocytes stimulated cholinergically in vitro: an E-rosetting inhibitor.
Human lymphocytes submitted to the influence of acetylcholine in vitro presented an early increase in the content of E-rosettes. These cells also reacted to this cholinergic stimulation in vitro by releasing a factor affecting E-rosetting formation. The factor was found to be released to the medium after 2 hours of stimulation and decreased the E-rosette formation. The nature of the factor is not yet known, but it can be assumed that it is a polypeptide with a molecular weight of less than 2 min. The inhibition of E-rosetting was found to be dose-dependent, and the factor also affects muscarinic cholinergic binding (3H-QNB) to the rat brain membranes.
Bortkiewicz
H
H
Department of Pathophysiology, Institute of Rheumatology, Warsaw, Poland.
Ryzewski
J
J
D000109:Acetylcholine / Q000494:pharmacology*; D000328:Adult; D000818:Animals; D001685:Biological Factors / Q000378:metabolism* / Q000494:pharmacology; D001921:Brain / Q000166:cytology / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D002850:Chromatography, Gel; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000378:metabolism*; D015213:Neuroimmunomodulation; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D012397:Rosette Formation
D001685:Biological Factors; D011813:Quinuclidinyl Benzilate; D000109:Acetylcholine