title: [Rhabdomyosarcomas discovered in newborn infants. Study of markers of muscle differentiation].
abstract: Rhabdomyosarcomas were observed at birth in two premature infants. The evolution of these tumors was both rapid and fatal. One case was a botryoid sarcoma of the bladder and the second was a cervical alveolar sarcoma of Riopelle and Thériault. A cytological differentiation of the tumor was observed in the first case spontaneously and in the second following chemotherapy. In the second case histology, immunocytochemistry and a novel biochemical analysis of the contractile proteins demonstrated this differentiation of the tumor. The cellular reactivity varies according to the degree of muscular differentiation that can be defined either by studying the type of intermediate filaments present or the expression of specific muscle contractile proteins.
authors.affiliation: Service d'Anatomie Pathologique, Hôpital Saint Vincent de Paul, Paris.
authors.forename: J P
authors.initials: JP
authors.lastname: Barbet
authors.forename: J Y
authors.initials: JY
authors.lastname: Kurzenne
authors.forename: G S
authors.initials: GS
authors.lastname: Butler-Browne
authors.forename: V
authors.initials: V
authors.lastname: Mouly
authors.forename: M
authors.initials: M
authors.lastname: Laurent
authors.forename: J P
authors.initials: JP
authors.lastname: Gubler
mesh_terms: D005260:Female; D006258:Head and Neck Neoplasms / Q000151:congenital* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000473:pathology*; D008297:Male; D009334:Neck Muscles / Q000473:pathology; D012208:Rhabdomyosarcoma / Q000151:congenital* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000151:congenital* / Q000473:pathology
vernacular_title: Rhabdomyosarcomes de découverte néonatale. Etude des marqueurs de différenciation musculaire.