Parameters Vm' and Km for elimination of alcohol in young male subjects following low doses of alcohol.
Seventy-four (44 under fasting conditions and 30 following oral liquid meals) sets of post-absorptive human capillary blood alcohol concentration-time data were computer-fitted to the integrated form of the Michaelis-Menten equation by numerical integration by nonlinear least squares to provide 74 pairs of the kinetic Vm' and Km parameter values. The parameters were highly correlated (r = 0.915) by orthogonal least squares. Eight of the fasting subjects received four different oral doses of alcohol and fourteen subjects each received three different alcohol treatments. Intra-subject variances of Vm', Km and the ratio Vm' Km were calculated from the multiple treatments. Inter-subject variances were calculated from the 22 mean values of each parameter. Each parameter and the intra-subject variances of the parameters were found to be log normally distributed. The liquid meals (carbohydrate, fat and protein separately) appeared not to affect the parameter values. The computer fittings were all excellent as evidenced by the relatively small standard deviations of the estimated parameters and other statistical measures of fit.
Wagner
J G
JG
College of Pharmacy, University of Michigan, Ann Arbor 48109.
Wilkinson
P K
PK
Ganes
D A
DA
D000328:Adult; D000428:Alcohol Drinking / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000493:pharmacokinetics*; D005215:Fasting / Q000097:blood; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology
D000431:Ethanol