title: [Mass-spectrometric analysis of an anti-microbial preparation decamethoxine].
abstract: I. I. Mechnikov Kharkov Research Institute of Microbiology, Vaccines and Sera, Ministry of Public Health of the Ukrainian SSR. The results of mass spectrometric investigation of decamethoxine++, an antimicrobial chemotherapeutic drug, are presented. It was shown that desorption-field mass spectrometry provided recording decamethoxine++ intensive quasimolecular ions [M.Cl]+ and [M]++ forming under conditions of high electric intensity only from the intact parent molecule. Hence, the presence of the peaks in the desorption field mass spectra made it possible to definitively determine decamethoxine++ in the samples. Therefore, the procedure of desorption-field mass spectrometry proved reliable in identification of bisquaternary ammonium compounds. Ways for thermal decomposition and mass spectrometric fragmentation of the decamethoxine++ molecule under various ionization conditions are also discussed.
authors.forename: L F
authors.initials: LF
authors.lastname: Sukhodub
authors.forename: M V
authors.initials: MV
authors.lastname: Kosevich
authors.forename: V S
authors.initials: VS
authors.lastname: Shelkovskiĭ
authors.forename: Iu L
authors.initials: IuL
authors.lastname: Volianskiĭ
mesh_terms: D000890:Anti-Infective Agents / Q000032:analysis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003650:Decamethonium Compounds / Q000032:analysis* / Q000494:pharmacology; D004355:Drug Stability; D006358:Hot Temperature; D066298:In Vitro Techniques; D013058:Mass Spectrometry / Q000379:methods; D008968:Molecular Conformation
chemical_list: D000890:Anti-Infective Agents; D003650:Decamethonium Compounds; C000858:decamethoxine
vernacular_title: Mass-spectrometricheskoe issledovanie antimikrobnogo preparata dekametoksina.