title: [The effect of amplifying reproduction of influenza virus in mouse lungs during simultaneous infection with two cold-adapted strains].
abstract: Reproduction of cold-adapted (ca) strains of influenza virus in the lungs of white mice after separate and combined inoculation and the properties of isolates derived from the infected animals were studied. It was shown that after combined inoculation with ca and ts strains A/Leningrad/134/17/57 (H2N2) and A/PR/8/59/1 (H1N1) ca recombinants could develop loosing some ts mutations and possessing (unlike the master strains) pneumo-virulence for mice. All the pneumo-virulent reassortants inherited hemagglutinin from the ca A/PR/8/59/1 strain and PB1 protein from the ca A/Leningrad/134/17/57 strain. The results indicate that it is unsafe to construct live recombinant divaccines by combining the recombinants produced from different donors of attenuation.
authors.forename: Iu R
authors.initials: IuR
authors.lastname: Romanov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Egorov
authors.forename: K V
authors.initials: KV
authors.lastname: Lisovskaia
authors.forename: T E
authors.initials: TE
authors.lastname: Medvedeva
authors.forename: G N
authors.initials: GN
authors.lastname: Nevedomskaia
authors.forename: G I
authors.initials: GI
authors.lastname: Aleksandrova
authors.forename: A I
authors.initials: AI
authors.lastname: Klimov
mesh_terms: D000220:Adaptation, Biological; D000818:Animals; D003080:Cold Temperature; D009980:Influenza A virus / Q000472:pathogenicity / Q000502:physiology*; D008168:Lung / Q000382:microbiology*; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000382:microbiology*; D014779:Virus Replication
vernacular_title: Effekt usileniia reproduktsii virusa grippa v legkikh mysheĭ pri odnobremennom infitsirovanii dvumia kholodoadaptirovannymi shtammami.