title: Soil particles in the tissues of the foot in endemic elephantiasis of the lower legs.
abstract: The presence of microparticles of clay is demonstrated in the dermis of the foot in a patient with endemic elephantiasis. The particles are seen to be in the phagosomes of macrophages or in the cytoplasm of other cells. The conducting lymphatic in the subdermal tissue is found to be impermeable to Patent Blue Violet dye and to be fibrosed. The failure to conduct lymph to the node produces a permanent deposit of silica in the dermal tissues; a parallel is drawn with similar deposits in the lung in pneumoconiosis.
authors.affiliation: Tenovus Institute for Cancer Research, The Heath, Cardiff, U.K.
authors.forename: G
authors.initials: G
authors.lastname: Blundell
authors.forename: W J
authors.initials: WJ
authors.lastname: Henderson
authors.forename: E W
authors.initials: EW
authors.lastname: Price
mesh_terms: D000328:Adult; D004577:Electron Probe Microanalysis; D004604:Elephantiasis / Q000473:pathology*; D005260:Female; D005528:Foot / Q000473:pathology*; D006801:Humans; D008209:Lymphedema / Q000473:pathology*; D008264:Macrophages / Q000648:ultrastructure; D008854:Microscopy, Electron; D012867:Skin / Q000473:pathology* / Q000648:ultrastructure; D012987:Soil
chemical_list: D012987:Soil