title: 9;22 translocation and bcr rearrangements in chronic myelocytic leukemia patients among atomic bomb survivors.
abstract: To elucidate the mechanism of leukemia induced by radiation, we studied both chromosome abnormalities and bcr rearrangements of seven CML patients with a history of atomic bomb exposure and 14 CML patients without the exposure. All patients, irrespective of radiation exposure, had 9;22 translocation and rearrangement of the bcr gene in the leukemic cells. Further analysis of breakpoints within the bcr gene demonstrated no distinct difference between the exposed and the non-exposed groups. The present study suggests that formation of the chimeric bcr-abl gene and its genetic products may play an important role in the development of leukemia in either radiation-induced or de novo CML.
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Takechi
authors.forename: J
authors.initials: J
authors.lastname: Hong
authors.forename: C
authors.initials: C
authors.lastname: Shigeta
authors.forename: N
authors.initials: N
authors.lastname: Oguma
authors.forename: N
authors.initials: N
authors.lastname: Kamada
authors.forename: Y
authors.initials: Y
authors.lastname: Takimoto
authors.forename: A
authors.initials: A
authors.lastname: Kuramoto
authors.forename: H
authors.initials: H
authors.lastname: Dohy
authors.forename: T
authors.initials: T
authors.lastname: Kyo
mesh_terms: D000328:Adult; D000368:Aged; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007564:Japan; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D007953:Leukemia, Radiation-Induced / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009689:Nuclear Warfare; D014178:Translocation, Genetic