title: The effect of starch glove powder on joint and other tissues.
abstract: The purpose of this research was to establish the possible role of starch glove powder in complications following orthopaedic surgery using in vivo and in vitro techniques. Exposure of primary mouse peritoneal macrophages to starch glove powder caused 10% release of prostaglandin E2 (0.1 mg/ml, 16 h) but no increased release of lactate dehydrogenase, demonstrating that cell integrity had not been compromised. Long-term tissue reaction to starch glove powder was investigated in vivo by injection into mouse knee joints. Over a period of 52 weeks no inflammatory response was elicited, no starch was observed in the regional lymph nodes and none was found in joints after the 8th week. Starch glove powder appeared to be innocuous in the joint and although prostaglandin E2 release was stimulated in vitro, this had no apparent effect on joints in vivo.
authors.affiliation: University of Cambridge, Orthopaedic Research Unit.
authors.forename: T
authors.initials: T
authors.lastname: Rae
authors.forename: L A
authors.initials: LA
authors.lastname: McCormick-Thomson
authors.forename: D W
authors.initials: DW
authors.lastname: Murray
authors.forename: N
authors.initials: N
authors.lastname: Rushton
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D007719:Knee Joint / Q000187:drug effects* / Q000473:pathology; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D011208:Powders / Q000009:adverse effects; D013213:Starch / Q000009:adverse effects*
chemical_list: D011208:Powders; D013213:Starch; D015232:Dinoprostone