[Plasminogen activator activity of the synovial fluid as an indicator of activation phenomena in degenerative joint diseases].
Activity of plasminogen activator in synovial fluids of patients with osteoarthritis was determined by a radial diffusion assay. Synovial fluid from human knee joints was obtained by joint lavage with 35 ml physiological saline containing 0.5% hydroxyethyl starch. Synovial fluids from contralateral, healthy knee joints served as controls. The activity of plasminogen activator in synovial fluid from activated (painful) osteoarthritis is significantly higher than in cases of latent osteoarthritis, whereas the activity of controls is significantly lower as in latent osteoarthritis. The findings are helpful for the discovery of patients with enhanced plasminogen activator levels in synovia which should be treated therapeutically.
Lindenhayn
K
K
Klinik und Poliklinik für Orthopädie, Bereiches Medizin (Charité) der Humboldt-Universität zu Berlin, DDR.
Heilmann
H H
HH
Regling
G
G
Haupt
R
R
D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007719:Knee Joint / Q000032:analysis; D010003:Osteoarthritis / Q000175:diagnosis*; D010960:Plasminogen Activators / Q000032:analysis*; D013582:Synovial Fluid / Q000032:analysis*
D010960:Plasminogen Activators
Die Plasminogenaktivator-Aktivität der Synovialflüssigkeit als Indikator für Aktivierungsphänomene bei degenerativen Gelenkerkrankungen.