Biological evaluation of mitoxantrone dihydrochloride synthesized by a new method. II. Comparison of Now 85/34 and Novantrone (Lederle) acute toxicity and antitumor activity.
A basic biological similarity of the newly synthesized mitoxantrone dihydrochloride preparation Now 85 with the Lederle's Novantrone was tested in simultaneously carried out comparative evaluations of acute toxicity and antitumor activity.
Matuszyk
J
J
Department of Tumor Immunology, Polish Academy of Sciences, Wrocław.
Kuśnierczyk
H
H
Radzikowski
C
C
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D007942:Leukemia, Experimental / Q000188:drug therapy; D008297:Male; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D008942:Mitoxantrone / Q000138:chemical synthesis / Q000627:therapeutic use / Q000633:toxicity*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*
D000970:Antineoplastic Agents; D008942:Mitoxantrone