[Morphological observation of termination of early pregnancy with anordrin in mice].
Twenty four mice were divided randomly into experimental and control groups. There were 10 animals in the control group. In experimental group, anordrin (3 mg/kg) was injected into the peritoneal cavity to terminate early pregnancy. The control group was treated with normal saline. Pathological changes in the decidual cells, blastocysts (including giant cells), corpora lutea and embryo were observed. It was found that the animals in the control group were developing normally. In all the experimental groups decidual cells and blastocysts showed degeneration and necrosis. The granulosa lutein cells also showed degeneration. The dead embryo was embedded in the necrotic decidual cells and blastocysts. The mechanism concerned may involve a combination of various factors. The degeneration of granulosa lutein cells may be the most important of the factors.
Ou
K Q
KQ
Chen
W Y
WY
Ma
Y Q
YQ
Lu
B
B
Zhao
F Y
FY
D000818:Animals; D001755:Blastocyst / Q000187:drug effects; D003281:Contraceptives, Postcoital; D003338:Corpus Luteum / Q000187:drug effects*; D003656:Decidua / Q000166:cytology / Q000187:drug effects; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D007274:Injections, Intraperitoneal; D008184:Luteal Cells / Q000187:drug effects*; D051379:Mice; D009635:Norandrostanes / Q000494:pharmacology*; D011247:Pregnancy
D003281:Contraceptives, Postcoital; D009635:Norandrostanes; C010855:anordrin