title: Small-volume resuscitation with hypertonic saline solution in hypovolemic cats.
abstract: We evaluated the hemodynamic effects of IV and intraaortic (aortic root) administration of 7.5% NaCl solution on hemodynamics in anesthetized cats with severe hypovolemia. Hypovolemic shock was induced by exsanguinating cats to a mean arterial blood pressure of 50 mm of Hg, which was maintained for 30 minutes prior to treatment. Shed blood volume was 38.4 +/- 2.1 ml/kg of body weight. The cats were treated with a small volume (4 ml/kg) of 0.9% NaCl solution IV, 7.5% NaCl solution IV, or 7.5% NaCl solution administered into the aortic root. The IV administration of 0.9% NaCl solution did not improve hemodynamics. The IV administration of 7.5% NaCl solution induced rapid restoration of arterial blood pressure, aortic blood flow, and cardiac contractility. Total peripheral vascular resistance decreased. The administration of 7.5% NaCl solution into the aortic root induced a further deterioration in hemodynamics resulting in death in 3 cats and a marked improvement in hemodynamics similar to that observed after IV administration of 7.5% NaCl solution in 2 cats. The duration of the beneficial hemodynamic effects after IV or intra-aortic administration of 7.5% NaCl solution did not exceed 60 minutes. Results of these studies suggested that either the IV or intra-aortic administration of 7.5% NaCl solution in cats can induce beneficial hemodynamic effects that may be of value in the field resuscitation of hypovolemic patients.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210-1089.
authors.forename: W W
authors.initials: WW
authors.lastname: Muir
authors.forename: J
authors.initials: J
authors.lastname: Sally
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002371:Cat Diseases / Q000628:therapy*; D002415:Cats; D006439:Hemodynamics; D007261:Infusions, Intra-Arterial / Q000662:veterinary; D007262:Infusions, Intravenous / Q000662:veterinary; D009200:Myocardial Contraction; D011897:Random Allocation; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012769:Shock / Q000628:therapy / Q000662:veterinary*; D014655:Vascular Resistance
chemical_list: D012462:Saline Solution, Hypertonic