[Nicotine gum and lipid profile].
Smoking promotes for atherosclerosis by several mechanisms and particularly its actions on lipid metabolism; nicotine liability is well established. In one patient the use of nicotine-gum was reported to increase total cholesterol and LDL cholesterol. We studied lipid modifications in 14 voluntary students, heavy smokers (greater than 20 cigarettes/day) and nicotine dependent (Fagerström test; score greater than 7). They gave up smoking and received in double blind study either 2 mg nicotine-gum, or placebo-gum (8-12 gums a day for one month). Total and HDL cholesterol (chol.), triglycerides (TG) were measured at day 0, day 30 and day 60. Giving up smoking was ascertained by CO-analyser. At day 30 total chol and TG were unmodified, and HDL chol appeared slightly increased. At day 60 HDL and LDL chol were significantly improved. So in nicotine-dependent smokers, by giving up smoking and receiving 2 mg nicotine-gum, lipid patterns are not worsened but improved.
Lagrue
G
G
Centre d'Aide au Sevrage Tabagique INSERM U.139, Hôpital Henri-Mondor, Créteil, France.
Grimaldi
B
B
Martin
C
C
Demaria
C
C
Jacotot
B
B
D000328:Adult; D002638:Chewing Gum; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D012907:Smoking / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D002638:Chewing Gum; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D009538:Nicotine; D002784:Cholesterol
Gomme nicotine et profil lipidique.