Synthesis and antitumour effect of N alpha-acyl derivatives of L-cystine-bis [N,N-di(2-chloroethyl)]dihydrazide.
A series of Na-acyl derivatives of L-cystine-bis [N,N-di(2-chloroethyl)]dihydrazide was synthesized. The effect of the acyl substituent on the antitumour activity of the synthesized compounds was studied. It was demonstrated that the introduction of short-chain Na-acyl substituents resulted in substances with higher antitumour effect and lower toxicity.
Zakhariev
S
S
Institute of Molecular Biology, Bulgarian Academy of Sciences, Medical Academy Sofia.
Stoev
S
S
Maneva
K
K
Ilarionova
M
M
Todorov
D
D
Golovinsky
E
E
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D003553:Cystine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D009588:Nitrogen Mustard Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000970:Antineoplastic Agents; D009588:Nitrogen Mustard Compounds; D003553:Cystine