Horizontal transmission in sheep and delayed clearance in guinea pigs and mice of a Brucella melitensis Rev. I mutant.
Virulence assays in guinea-pigs, mice and sheep with a Rev. I mutant strain (FSA) demonstrated that the latter had increased virulence in comparison with a reference strain. The mutant showed slower clearance in guinea-pigs and mice when compared with standard Rev. I strains and horizontal transmission was achieved in 2 sheep.
Hunter
P
P
Veterinary Research Institute, Onderstepoort, Republic of South Africa.
Pefanis
S M
SM
Williamson
C C
CC
Botha
W J
WJ
Van Schalkwyk
M S
MS
D000818:Animals; D002002:Brucella / Q000472:pathogenicity*; D005260:Female; D006168:Guinea Pigs; D051379:Mice; D009154:Mutation; D011247:Pregnancy; D012756:Sheep; D014774:Virulence