[Total synthesis and properties of prostaglandins. XXI. Synthesis of a 4,4-dimethyl-4-sil analog of 11-deoxyprostaglandin E1].
Total synthesis of a new prostaglandin analogue, 11-deoxy-4,4-dimethyl-4-sil-prostaglandin E1, is carried out through synthesis of a silicon-containing alpha-chain precursor and a 2-substituted cyclopentenone derivative followed by their cuprate-induced interaction.
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D000527:Alprostadil / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D011459:Prostaglandins E, Synthetic / Q000138:chemical synthesis*
D011459:Prostaglandins E, Synthetic; C062943:11-deoxy-4,4-dimethyl-4-silaprostaglandin E1; D000527:Alprostadil; C034008:11-deoxyprostaglandin E1
Total'nyĭ sintez i svoĭstva prostaglandinov. XXI. Sintez 4,4-dimetil-4-sila-analoga 11-dezoksiprostaglandina E1.