Hatching of Schistosoma mansoni eggs is a Ca2+/calmodulin-dependent process.
The effect of calcium channel blockers (diltiazem and verapamil) and a calmodulin antagonist (W-7) on the hatching of Schistosoma mansoni eggs in fresh water was studied. The hatching of the eggs was inhibited by diltiazem and W-7 in a dose-dependent fashion and only slightly by verapamil. The present study indicates that the hatching of S. mansoni eggs is a Ca2+/calmodulin-dependent process.
Katsumata
T
T
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Kohno
S
S
Yamaguchi
K
K
Hara
K
K
Aoki
Y
Y
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004110:Diltiazem / Q000494:pharmacology; D012550:Schistosoma mansoni / Q000187:drug effects / Q000502:physiology*; D013449:Sulfonamides / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology; D015053:Zygote / Q000187:drug effects / Q000502:physiology*
D002147:Calmodulin; D013449:Sulfonamides; C017967:W 7; D014700:Verapamil; D004110:Diltiazem; D002118:Calcium