title: Cortical and medullary kidney tissue levels of cefonicid in human beings.
abstract: Cefonicid concentration has been determined microbiologically in cortical and medullary tissue in 30 patient undergoing surgery because of neoplastic disease localized within the kidney. Each subject received 1 g of cefonicid intramuscularly in a single administration. The patients were divided into six groups, from which samples of blood and tissue were collected 2, 4, 6, 8, 12, 24 h respectively after treatment with the drug. The mean peak serum levels appeared at the second hour (74.96 +/- 8.14 mcg/ml) and the decay shows a monoexponential behaviour, reaching a minimum value of 5.4 +/- 2.33 mcg/ml at the 24th hour. In the cortical tissue of the kidney the peak levels appeared at the fourth hour (26.22 +/- 8.87 mcg/g), while at the 24th hour levels were about 3.08 +/- 0.81 mcg/g. A very similar behaviour could also be observed in the medullary tissue of the kidney with peak levels at the fourth hour (25.82 +/- 10.06 mcg/g) and levels of 3.48 +/- 0.85 mcg/g at the 24th hour. A delay in the decay of tissue levels in comparison with the decay of blood levels could be observed from the eighth hour.
authors.affiliation: Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Scaglione
authors.forename: F
authors.initials: F
authors.lastname: Ferrara
authors.forename: G
authors.initials: G
authors.lastname: Maierna
authors.forename: M
authors.initials: M
authors.lastname: Falchi
authors.forename: G
authors.initials: G
authors.lastname: Comeri
authors.forename: F
authors.initials: F
authors.lastname: Fraschini
mesh_terms: D000328:Adult; D000368:Aged; D015790:Cefonicid / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007672:Kidney Cortex / Q000378:metabolism*; D007679:Kidney Medulla / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000378:metabolism / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D015790:Cefonicid