title: Effect of i.v. omeprazole on the pH and volume of gastric contents before surgery.
abstract: Gastric pH and volume were measured in 87 patients who had received i.v. omeprazole (a new gastric antisecretory agent) 40 mg or placebo 1 or 3 h before surgery. Omeprazole increased the pH of gastric contents in the majority of patients. Administration 1 h before surgery produced greater gastric pH and smaller volume than administration 3 h before surgery. There was a reduction in the number of patients with a pH of less than 2.5 and a volume of 25 ml or more in the treated groups compared with the combined placebo groups. Omeprazole may have a role in prophylaxis against acid aspiration syndrome.
authors.affiliation: Department of Anaesthesia, University of Sheffield.
authors.forename: R H
authors.initials: RH
authors.lastname: Cruickshank
authors.forename: D A
authors.initials: DA
authors.lastname: Morrison
authors.forename: P A
authors.initials: PA
authors.lastname: Bamber
authors.forename: W S
authors.initials: WS
authors.lastname: Nimmo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D004311:Double-Blind Method; D005260:Female; D005766:Gastrointestinal Contents / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000494:pharmacology* / Q000627:therapeutic use; D011015:Pneumonia, Aspiration / Q000517:prevention & control; D011292:Premedication; D013997:Time Factors
chemical_list: D009853:Omeprazole