Effect of shosaikoto on plasma catecholamines.
Plasma adrenaline (AD) and noradrenaline (NA) were determined using high performance liquid chromatography (HPLC) equipped with an electrochemical detector. In an experiment using non-treated adrenalectomized rats, most plasma AD appeared to originate from the adrenal medulla, while plasma NA came from other sites. When Shosaikoto, a Japanese and Chinese traditional medicinal mixture, was orally administered to rats, plasma AD levels decreased in a significant manner 60 min after treatment, while plasma NA levels were not changed. Pretreatment with pentobarbital inhibited the Shosaikoto-induced decrease of plasma AD levels.
Amagaya
S
S
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Ogihara
Y
Y
D000313:Adrenal Medulla / Q000378:metabolism; D000315:Adrenalectomy; D000818:Animals; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004837:Epinephrine / Q000097:blood* / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D004365:Drugs, Chinese Herbal; C461321:shosaikoto-go-keishika-shakuyakuto; D010424:Pentobarbital; D009638:Norepinephrine; D004837:Epinephrine