Pre-exposure vaccination with purified chick embryo cell rabies vaccines in children.
Children who have close contact with rabid dogs, with a history of neither being bitten nor scratched nor licked on broken skin or on mucous membranes were given purified chick embryo rabies vaccine as pre-exposure prophylaxis. Thirteen children received 0.5 ml of the vaccine, while 12 children received 1 ml of the vaccine intramuscularly on days 0, 7 and 28. The rabies antibody level was measured by a standard mouse neutralization test. Before vaccination, all vaccinees had no detectable level of antibody to rabies. On day 14, all children had antibody levels higher than 0.5 IU/ml; the titer peaked from day 28 to day 56 and then was lower on day 90. Children of the 1 ml group had antibody levels higher than the 0.5 ml group, but there was no statistically significant difference. No serious reaction occurred. At 2-3 years of follow up, all children were doing well.
Lumbiganon
P
P
Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Thailand.
Chaiprasithikul
P
P
Sookpranee
T
T
Paholpak
S
S
Wasi
C
C
D000293:Adolescent; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000276:immunology; D002642:Chick Embryo; D002648:Child; D002675:Child, Preschool; D004285:Dogs; D005260:Female; D006801:Humans; D008297:Male; D011818:Rabies / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage*; D013785:Thailand
D000914:Antibodies, Viral; D011819:Rabies Vaccines