Effect of gallium nitrate on the in vivo distribution of 67Ga in rats bearing inflammatory lesions.
Effect of gallium nitrate on the pharmacokinetics and tissue accumulation of 67Ga was investigated in rats bearing turpentine oil-induced abscess. Gallium nitrate accelerated the blood disappearance of 67Ga, but this effect was less potent than that of ferric nitrate. The accumulation of 67Ga in liver was significantly lowered by gallium nitrate, but no significant decrease of 67Ga accumulation in abscess was observed. On the other hand, 67Ga accumulation in bone was slightly facilitated by gallium nitrate. Ferric nitrate exerted a similar effect on tissue accumulation of 67Ga as gallium nitrate.
Kohno
H
H
Department of Radiopharmacy, Tohoku College of Pharmacy, Sendai-shi, Japan.
Kanayama
S
S
Ohkubo
Y
Y
Kubodera
A
A
D000038:Abscess / Q000139:chemically induced / Q000378:metabolism*; D000818:Animals; D005290:Ferric Compounds / Q000494:pharmacology; D005708:Gallium / Q000494:pharmacology*; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics*; D008297:Male; D009566:Nitrates; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014425:Turpentine
D005290:Ferric Compounds; D005710:Gallium Radioisotopes; D009566:Nitrates; D005708:Gallium; C025302:ferric nitrate; C027235:gallium nitrate; D014425:Turpentine