Microinjection of anti-vasopressin serum into hippocampus in mice: effects on appetitively reinforced task after intraventricular administration of Arg-vasopressin.
Antiserum to [Arg8]vasopressin (anti-AVP) was bilaterally administered into dorsal hippocampus at 1:50 or 1:10 dilution 20 min before the 24-day retention session of a visual discrimination task. This treatment by itself did not affect the retention performance by comparison with the respective control group, whatever the dilution of anti-AVP, suggesting that hippocampal endogenous AVP is not involved in our behavioral paradigm. On the other hand, intracerebroventricular (i.c.v.) administration of AVP 10 min before the retention session improved retention performance of the visual discrimination task. When anti-AVP was injected at the 1:10 dilution into the dorsal hippocampus 10 min before the i.c.v. administration of AVP, the retention performance was not improved. These data suggest the involvement of the hippocampus in the behavioral expression of AVP following an i.c.v. treatment.
Alescio-Lautier
B
B
Laboratoire de Neurobiologie des Comportements, CNRS U.A. 372 Université de Provence, Marseille, France.
Metzger
D
D
Devigne
C
C
Soumireu-Mourat
B
B
D000818:Animals; D001127:Arginine Vasopressin / Q000276:immunology / Q000502:physiology*; D004193:Discrimination Learning / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D007106:Immune Sera / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008845:Microinjections; D012153:Retention, Psychology / Q000187:drug effects*; D014795:Visual Pathways / Q000187:drug effects / Q000502:physiology
D007106:Immune Sera; D001127:Arginine Vasopressin