title: The effect of indomethacin on experimental dental periapical lesions in rats.
abstract: The role of prostaglandins in the pathogenesis of dental granulomas and associated bone loss was studied by testing the ability of indomethacin, a potent inhibitor of prostaglandin synthesis, to influence bone resorption in experimentally induced dental granulomas. The cusps of maxillary first molar teeth of Sprague-Dawley rats were ground away, exposing the dental pulps to the oral environment. Daily i.p. injections of 0.1 to 0.2 ml of indomethacin (10 mg per kg) dissolved in 95% ethyl alcohol were administered to one group of the rats while the other group received i.p. injections of 0.1 to 0.2 ml of 95% ethyl alcohol. The rats were killed after 6 wk and specimens of the molar teeth and surrounding jaw bone were taken for routine histopathological processing. The specimens from indomethacin-treated rats demonstrated milder inflammatory changes and a significantly lower degree of periapical alveolar bone resorption. These results support the suggestion that prostaglandins are involved in the events leading to bone resorption in dental periapical lesions.
authors.forename: B R
authors.initials: BR
authors.lastname: Oguntebi
authors.forename: B F
authors.initials: BF
authors.lastname: Barker
authors.forename: D M
authors.initials: DM
authors.lastname: Anderson
authors.forename: J
authors.initials: J
authors.lastname: Sakumura
mesh_terms: D000818:Animals; D001862:Bone Resorption; D007213:Indomethacin / Q000627:therapeutic use*; D010483:Periapical Diseases / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007213:Indomethacin