[Inhibitory effect of inositol hexasulfate and inositol hexaphosphoric acid (phytic acid) on the proliferation of the human immunodeficiency virus (HIV) in vitro].
The monosaccharide substances inositol hexasulfate (IHS) and inositol hexaphosphoric acid (Phytic acid, IHP) were investigated for their antiviral effect on the human immunodeficiency virus (HIV) in vitro. In MT-4 cells IHS completely inhibited the cytopathic effect of HIV and the HIV specific antigen expression at a concentration of 1.67 mg/ml. IHP moderately inhibited both of HIV effects as mentioned above.
Otake
T
T
Shimonaka
H
H
Kanai
M
M
Miyano
K
K
Ueba
N
N
Kunita
N
N
Kurimura
T
T
D000998:Antiviral Agents; D006678:HIV / Q000187:drug effects* / Q000254:growth & development; D015490:HTLV-I Infections / Q000473:pathology; D006801:Humans; D007294:Inositol / Q000031:analogs & derivatives* / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects / Q000382:microbiology; D010833:Phytic Acid / Q000494:pharmacology*
D000998:Antiviral Agents; C013063:inositol hexasulfate; D007294:Inositol; D010833:Phytic Acid