title: [Preparation and antileukemic activity of quinolizidinylalkyl-derivatives of 4-aminoquinoline and 9-aminoacridine].
abstract: By reacting three quinolizidinylalkylamines with 4,7-dichloroquinoline and 6,9-dichloro-2-methoxyacridine six derivatives of 4-aminoquinoline and 9-aminoacridine were obtained. These compounds, which are of interest as potential antibacterial, antiprotozoarian, anti-helminthic and antitumoral agents, so far have been tested against lymphocytic leukemia P 388 and found to be inactive.
authors.forename: C
authors.initials: C
authors.lastname: Boido Canu
authors.forename: V
authors.initials: V
authors.lastname: Boido
authors.forename: F
authors.initials: F
authors.lastname: Sparatore
mesh_terms: D000609:Aminoacridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D011807:Quinolizines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000609:Aminoacridines; D000634:Aminoquinolines; D000970:Antineoplastic Agents; D011807:Quinolizines; C001920:4-aminoquinoline
vernacular_title: Preparazione e attività antileucemica di chinolizidinil-alchil derivati della 4-amminochinolina e della 9-amminoacridina.