title: Heteroarylalkanoic acids with possible antiinflammatoric activities. Part 6: 3-(4H-1,2,4-benzothiadiazine-1,1-dioxide-3-yl-thio)-propanoic acid derivatives.
abstract: A series of 3-(4H-1,2,4-benzothiadiazine-1,1-dioxide-3-yl-thio)-propanoic acids was synthesized in order to study their possible antiinflammatory in comparison with the corresponding lower homologues and isosters previously studied. Most of the compounds proved effective against carrageenan-induced plantar oedema. The possible influence of some chemico-physical parameters on the occurrence of this biological activity was investigated.
authors.affiliation: Cattedra di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia dell'Università di Modena, Italia.
authors.forename: G
authors.initials: G
authors.lastname: Gamberini
authors.forename: C
authors.initials: C
authors.lastname: Parenti
authors.forename: L
authors.initials: L
authors.lastname: Costantino
authors.forename: M
authors.initials: M
authors.lastname: Di Bella
authors.forename: L
authors.initials: L
authors.lastname: Raffa
authors.forename: T
authors.initials: T
authors.lastname: Rossi
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D001581:Benzothiadiazines / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003497:Cyclic N-Oxides / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D011422:Propionates / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001581:Benzothiadiazines; D003497:Cyclic N-Oxides; D011422:Propionates