Synthesis of dinucleoside phosphorodithioates from nucleoside phosphonodithioates.
The conversion, in good yield, of 5'-O-(9-phenylxanthen-9-yl) thymidine (1) into the triethylammonium salt of its 3'-phosphonodithioate (2a) is described. The latter compound (2a) is converted into a dinucleoside phosphonothioate (4a), and thence into a corresponding dinucleoside phosphorodithioate (6a) and phosphorothioate (6;X = 0).
Porritt
G M
GM
Department of Chemistry, King's College London, UK.
Reese
C B
CB
D015226:Dinucleoside Phosphates / Q000138:chemical synthesis*; D013873:Thionucleotides / Q000138:chemical synthesis*
D015226:Dinucleoside Phosphates; D013873:Thionucleotides