[Recurrent gastroparesis following abdominal irradiation. Therapy with cisapride].
Following abdominal radiation a 16-year-old male patient developed nausea and vomiting secondary to gastric stasis, dilatation and impairment of antral motility. Symptoms improved after 2 months of treatment with a cholinergic agonist. Now, 7 years later, symptoms recurred. Cisapride, a newly developed agent which stimulates gastrointestinal motility probably evoked a prompt increase of antral motility and gastric emptying. We conclude that abdominal irradiation may cause gastrointestinal motility disturbances which may respond to medical therapy.
Petrasch
S
S
Medizinische Klinik, Universitätsklinikum Essen.
Layer
P
P
Wehr
M
M
Goebell
H
H
D000293:Adolescent; D000328:Adult; D020117:Cisapride; D004407:Dysgerminoma / Q000532:radiotherapy*; D005500:Follow-Up Studies; D005746:Gastric Emptying / Q000187:drug effects / Q000528:radiation effects*; D005769:Gastrointestinal Motility / Q000528:radiation effects; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000532:radiotherapy*; D010880:Piperidines / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000188:drug therapy*; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D013724:Teratoma / Q000532:radiotherapy*; D013736:Testicular Neoplasms / Q000532:radiotherapy*
D010880:Piperidines; D012702:Serotonin Antagonists; D020117:Cisapride
Rezidivierende Gastroparese nach Abdomenbestrahlung. Therapie mit Cisaprid.