[The energy mechanism of phasic changes in the spontaneous electrical activity of the neurons during hypoxia].
The functional activity of the neurons directly depends on the energy metabolism of the cell, and as the hypoxic effect grows there takes place an interreplaceability of metabolic flows supplying the respiratory chain with energy substrates and reducing equivalents participating in the compensatory maintenance of the energy status of the cell (glycolysis, NAD-dependent oxidation and succinate oxidation in the terminal phase). Due to this, in a vast area of pO2 values there is retained a high degree of impulse activity of neurons characteristic of the specific electrogenic neuron function.
Luk'ianova
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LD
Vlasova
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IG
D000818:Animals; D002531:Cerebellum / Q000187:drug effects / Q000503:physiopathology; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D002534:Hypoxia, Brain / Q000503:physiopathology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D010313:Partial Pressure; D010507:Periodicity; D051381:Rats
Energeticheskiĭ mekhanizm faznykh izmeneniĭ spontannoĭ élektricheskoĭ aktivnosti neĭronov pri gipoksii.