title: High concentrations of 2-5A, the interferon intracellular mediator, in the blood of children with acute viral infections.
abstract: We measured the concentration of 2-5A (2',5'-oligoadenylate), an intracellular mediator of the antiviral action of interferon, in the blood of children with acute viral and bacterial infectious diseases. 2-5A concentration was found to be elevated in several children with viral diseases. This elevation seemed transient and was not specific for viral infections. We provide arguments for the use of 2-5A as a marker of the evolution of diagnosed viral diseases.
authors.affiliation: Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France.
authors.forename: A
authors.initials: A
authors.lastname: Luxembourg
authors.forename: L
authors.initials: L
authors.lastname: Laurence
authors.forename: M
authors.initials: M
authors.lastname: Tardieu
authors.forename: J M
authors.initials: JM
authors.lastname: Garnier
authors.forename: E
authors.initials: E
authors.lastname: Dussaix
authors.forename: H
authors.initials: H
authors.lastname: Cailla
mesh_terms: D000208:Acute Disease; D000227:Adenine Nucleotides / Q000097:blood*; D000293:Adolescent; D001424:Bacterial Infections / Q000097:blood / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007223:Infant; D008457:Measles / Q000097:blood* / Q000175:diagnosis; D008587:Meningitis, Viral / Q000097:blood* / Q000175:diagnosis; D008590:Meningoencephalitis / Q000097:blood* / Q000175:diagnosis; D009843:Oligoribonucleotides / Q000097:blood*; D011379:Prognosis; D011500:Protein Synthesis Inhibitors / Q000097:blood; D014777:Virus Diseases / Q000097:blood* / Q000175:diagnosis
chemical_list: D000227:Adenine Nucleotides; D009843:Oligoribonucleotides; D011500:Protein Synthesis Inhibitors; C023505:2',5'-oligoadenylate