title: Experimental cardio-depressant effects of clonixin.
abstract: 1. The cardiovascular effects of CLX were studied. 2. CLX induced hypotension, bradycardia, negative chronotropism and negative inotropism. 3. Electrophysiological studies showed a decrease of sinus venosus discharge frequency. The action potential configuration was changed: the overshoot amplitude and (dV/dt)max were reduced and duration increased. 4. CLX at higher concentrations displaced the maximum diastolic potential and phase 4 slow diastolic depolarization was lengthened. 5. The above findings could be explained by a depressant action of CLX on the electrical activity of the pacemaker cells, possibly by a modification of the slow calcium currents.
authors.affiliation: Departamento de Farmacologia, Facultad de Medicina, Universidad de Chile, Santiago.
authors.forename: D
authors.initials: D
authors.lastname: Bustamante
authors.forename: M
authors.initials: M
authors.lastname: Morales
authors.forename: T
authors.initials: T
authors.lastname: Pelissier
authors.forename: H
authors.initials: H
authors.lastname: Saavedra
authors.forename: H F
authors.initials: HF
authors.lastname: Miranda
authors.forename: C
authors.initials: C
authors.lastname: Paeile
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001001:Anura; D001794:Blood Pressure / Q000187:drug effects; D003002:Clonixin / Q000494:pharmacology*; D004594:Electrophysiology; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009539:Nicotinic Acids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D015656:Respiratory Mechanics / Q000187:drug effects; D012849:Sinoatrial Node / Q000187:drug effects / Q000502:physiology
chemical_list: D000889:Anti-Arrhythmia Agents; D009539:Nicotinic Acids; D003002:Clonixin