title: Carbon tetrachloride-induced experimental cirrhosis in the rat: a reappraisal of the model.
abstract: The goal of this study was to evaluate the presence of extrahepatic damage and the uniformity and reversibility of the histological findings in CCl4-induced liver cirrhosis in the rat. To verify these findings rats were sacrificed 2 and 10 weeks after a treatment consisting of ten intragastric doses of CCl4, administered weekly. All treated rats developed an irreversible micronodular cirrhosis with no damage to the brain, kidney and pancreas. Moreover, rats sacrificed 2 weeks after the last CCl4 dose showed a number of functional alterations usually observed in man. In particular, low branched chain/aromatic amino acids (BCAA/AAA) plasma ratio, high ammonia, low zinc and high insulin with normal blood glucose were obtained.
authors.affiliation: II Cattedra di Gastroenterologia, Università di Roma La Sapienza, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ariosto
authors.forename: O
authors.initials: O
authors.lastname: Riggio
authors.forename: A
authors.initials: A
authors.lastname: Cantafora
authors.forename: S
authors.initials: S
authors.lastname: Colucci
authors.forename: E
authors.initials: E
authors.lastname: Gaudio
authors.forename: C
authors.initials: C
authors.lastname: Mechelli
authors.forename: M
authors.initials: M
authors.lastname: Merli
authors.forename: S
authors.initials: S
authors.lastname: Seri
authors.forename: L
authors.initials: L
authors.lastname: Capocaccia
mesh_terms: D000596:Amino Acids / Q000097:blood / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D002251:Carbon Tetrachloride; D008099:Liver / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D008115:Liver Regeneration; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000596:Amino Acids; D002251:Carbon Tetrachloride