[CD33-positive acute lymphoblastic leukemia with breast tumor and cavernous sinus tumor].
A 38-year-old woman was diagnosed as acute lymphoblastic leukemia (L2) in Oct. 1985. After VP and AdVEMP therapy, complete remission was obtained. In Oct. 1987, she noticed bilateral breast tumors and leukemic cell infiltrations were shown in a biopsy specimen of the breast tumor. Bone marrow was occupied with 94 percent blasts. The second complete remission was achieved by the AdVP therapy. In Nov. 1988, she developed double vision and photophobia. The examinations of CT and MRI showed cavernous sinus tumor, and 20 percent blasts were recognized in a bone marrow aspirate. The leukemic cells were negative for peroxidase, but were positive for both lymphoid and myeloid cell surface markers (CD2, CD5, CD7, CD33). The two color flowcytometry showed that CD5 and CD33 were simultaneously expressed on the leukemic cells.
Ishida
T
T
Yoshimoto
M
M
Ono
A
A
Saitoh
N
N
Nakano
T
T
Higashide
T
T
Sugiyama
T
T
Hinota
Y
Y
Imai
K
K
Yachi
A
A
D000328:Adult; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis*; D001752:Blast Crisis / Q000276:immunology / Q000473:pathology; D001943:Breast Neoplasms / Q000276:immunology / Q000473:pathology*; D002426:Cavernous Sinus; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology / Q000473:pathology*; D063268:Sialic Acid Binding Ig-like Lectin 3
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C571163:CD33 protein, human; D063268:Sialic Acid Binding Ig-like Lectin 3