[Adrenal cortex function in patients after kidney transplantation treated with cyclosporin A with prednisone or Azathioprine with prednisone].
Cortisol and aldosterone secretion following an intravenous injection of 0.25 mg of Synacthen was investigated in 12 patients with renal transplants, treated with azathioprine and prednisone (the "azathioprine group") and in 16 kidney-transplanted patients treated with cyclosporin A and prednisone (the "cyclosporin group"), as well as in 12 healthy control subjects. Statistically significant low cortisol and aldosterone levels under basal conditions was found in both groups of patients with renal transplants as well as a significantly lower reactivity of cortisol secretion and a moderately lower reactivity of aldosterone secretion after Synacthen administration. The protocol of the immunosuppression employed had no effect on the severity of the hormonal abnormalities found.
Nieszporek
T
T
Grzeszczak
W
W
Kokot
F
F
Zukowska-Szczechowska
E
E
D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism*; D000328:Adult; D000450:Aldosterone / Q000378:metabolism; D001379:Azathioprine / Q000008:administration & dosage*; D003524:Cyclosporins / Q000008:administration & dosage*; D005260:Female; D006082:Graft Enhancement, Immunologic; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage*
D003524:Cyclosporins; D000450:Aldosterone; D001379:Azathioprine; D011241:Prednisone; D006854:Hydrocortisone
Czynność kory nadnerczy u chorych po przeszczepieniu nerki leczonych cyklosporyna A z prednisonem lub azatiopryna z prednisonem.