Loss of heterozygosity in human germinal tumors.
The frequency of losses of heterozygosity has been investigated in 14 germinal tumors of the testis. Nonrandom deletion of whole or part of chromosome 11 was observed in four cases. In addition, loss of heterozygosity of all the informative loci analyzed was detected in one ovarian teratoma, indicating its post-meiotic origin. These results suggest that different genetic mechanisms (chromosomal deletions or meiotic segregation) that unmask putative recessive mutations are involved in the onset of germinal tumors.
Radice
P
P
Divisione di Oncologia Sperimentale A, Istituto Nazionale Tumori, Milan, Italy.
Pierotti
M A
MA
Lacerenza
S
S
Mondini
P
P
Radice
M T
MT
Pilotti
S
S
Della Porta
G
G
D014408:Biomarkers, Tumor / Q000235:genetics; D015139:Blotting, Southern; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000235:genetics; D004407:Dysgerminoma / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D010051:Ovarian Neoplasms / Q000235:genetics; D011110:Polymorphism, Genetic; D013724:Teratoma / Q000235:genetics; D013736:Testicular Neoplasms / Q000235:genetics*
D014408:Biomarkers, Tumor; D015342:DNA Probes; D004273:DNA, Neoplasm