Studies on aldehyde dehydrogenase type V-A isozymes in liver disease.
Aldehyde dehydrogenase (ALDH) V-A isozymes in saliva were detected in 96 patients with or without liver disease in order to clarify the relationships of the presence or absence of ALDH V-A isozymes to the metabolism of acetaldehyde (Ac-CHO) and alcoholic liver disease. The incidence of ALDH V-A deficiency was not different between the patients with alcoholic liver disease and those with non-alcoholic liver disease, nor between the patients with liver disease and without liver disease in no relation to alcohol misuse. Ac-CHO metabolism was not different between ALDH V-A deficient and non-deficient patients even in the ALDH I-deficient patients. These results indicated that ALDH V-A isozymes play virtually no role in the metabolism of Ac-CHO and its deficiency is not related to the development of alcoholic liver disease.
Takase
S
S
Department of Internal Medicine, Kanazawa Medical University, Ishikawa, Japan.
Urashima
S
S
Yasuhara
M
M
Takada
A
A
D000079:Acetaldehyde / Q000097:blood; D000428:Alcohol Drinking / Q000502:physiology; D000444:Aldehyde Dehydrogenase / Q000097:blood* / Q000235:genetics; D006801:Humans; D007527:Isoenzymes / Q000097:blood* / Q000235:genetics; D008104:Liver Cirrhosis, Alcoholic / Q000201:enzymology; D008108:Liver Diseases, Alcoholic / Q000175:diagnosis / Q000201:enzymology* / Q000235:genetics; D008111:Liver Function Tests; D011110:Polymorphism, Genetic / Q000235:genetics; D012307:Risk Factors
D007527:Isoenzymes; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde