The renal effects of kainic acid.
The effect of kainic acid (KA), a potent neurotoxic agent, on the renal function of rats was investigated. Intrahippocampal and intraperitoneal KA injections (2.5 micrograms and 8 mg/kg, respectively) led to a decrease in glomerular filtration rate and U/P inulin ratio with a concomitant increase in the amount of excreted Na+. However, acid excretion was maintained. These findings support the idea of a straight connection between neurohormonal secretion and renal function and may provide an interesting model to study renal hemodynamic changes induced by neurological disturbances.
Gil
F Z
FZ
Departamento de Fisiologia, Escola Paulista de Medicina, São Paulo, Brasil.
Costa-Silva
V L
VL
Cavanal
M F
MF
Amado
D
D
Cavalheiro
E A
EA
D000138:Acidosis / Q000139:chemically induced*; D000818:Animals; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007444:Inulin / Q000378:metabolism; D007608:Kainic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D051381:Rats; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D012964:Sodium / Q000378:metabolism
D007444:Inulin; D012964:Sodium; D007608:Kainic Acid