Cytophotometric estimation of cell proliferation in breast cancer. Correlation to the clinical course during long-term follow-up.
Tumours from 117 patients with breast cancer operated during a 5-month period 1975-1976 were investigated by absorbance scanning cytophotometry. The relations of these data to breast cancer recurrence and death during a follow-up period of 8.5 years were analysed using Cox's proportional hazards model. When individually tested, nodal status, grade of malignancy and high rates of proliferation, as indicated by cells in S-phase, were statistically significant predictors of the clinical outcome. The risk ratio associated with S-phase decreased significantly over time from primary treatment. No significant relation was found between DNA-ploidy or tumour size and the clinical course. In the multivariate analysis, based on 76 patients, nodal status alone was a significant prognostic factor.
Hatschek
T
T
Department of Oncology, University Hospital, Linköping, Sweden.
Bjelkenkrantz
K
K
Carstensen
J
J
Nordenskjöld
B
B
Nordin
B
B
Stål
O
O
Stenkvist
B
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D003592:Cytophotometry; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology; D009367:Neoplasm Staging; D011003:Ploidies; D011379:Prognosis
D004273:DNA, Neoplasm