Behavioral and electroencephalographic effects of the adenosine1 agonist, L-PIA.
The effects of N6-(L-2-phenylisopropyl)-adenosine (L-PIA), an A1 agonist, were measured on both spontaneous locomotor activity and electroencephalographic (EEG) measures of sleep in rats. L-PIA strongly inhibited motor activity at 100 micrograms/kg intraperitoneally (IP), a dose which had no statistically significant effects on EEG-defined sleep. A higher dose of L-PIA (200 micrograms/kg) increased the latency to sleep initiation and inhibited later REM sleep. These results demonstrate that L-PIA can produce a state of apparent behavioral quiescence in the presence of EEG-defined arousal.
Martin
J V
JV
Department of Biology, Rutgers University, Camden, NJ 08102.
Berman
K F
KF
Skolnick
P
P
Mendelson
W B
WB
D000241:Adenosine / Q000031:analogs & derivatives*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010660:Phenylisopropyladenosine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011983:Receptors, Purinergic / Q000187:drug effects / Q000502:physiology*; D012890:Sleep / Q000187:drug effects*
D011983:Receptors, Purinergic; D010660:Phenylisopropyladenosine; D000241:Adenosine