title: Massive prolactinoma with galactorrhoea in a prepubertal boy.
abstract: An 8 year old prepubertal boy presented with raised intracranial pressure, left proptosis and was noted to have galactorrhoea. Cranial computerized tomography revealed a large pituitary tumour infiltrating the cavernous sinus and left orbit. The serum prolactin was 180,600 mU/l (normal value less than 360 mU/l). Prolactinomas are rare in children and galactorrhoea has not previously been reported in a prepubertal child. The management of massive prolactinomas is difficult, but the child presented has made an impressive response to a combination of treatment with surgery, dopamine agonist therapy and radiotherapy.
authors.affiliation: Department of Endocrinology, St Bartholomew's Hospital, London, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Ross
authors.forename: J M
authors.initials: JM
authors.lastname: McEniery
authors.forename: A
authors.initials: A
authors.lastname: Grossman
authors.forename: I
authors.initials: I
authors.lastname: Doniach
authors.forename: G M
authors.initials: GM
authors.lastname: Besser
authors.forename: M O
authors.initials: MO
authors.lastname: Savage
mesh_terms: D002648:Child; D003131:Combined Modality Therapy; D005687:Galactorrhea / Q000628:therapy*; D006801:Humans; D007775:Lactation Disorders / Q000628:therapy*; D008297:Male; D010911:Pituitary Neoplasms / Q000628:therapy*; D015175:Prolactinoma / Q000628:therapy*; D011627:Puberty