title: Protective immunity against Angiostrongylus cantonensis in rats following sensitizing infections.
abstract: Three strains (ACI, August and Wistar) of rats previously sensitized by oral infection with intact third-stage larvae of Angiostrongylus cantonensis developed significant protective immunity to challenge infections 6 weeks later. The degree of the immunity was highest in the August strain of rats, followed by Wistar and ACI rats. Protective immunity appears to affect both third-stage larvae and fourth- and/or fifth-stage worms. ACI rats showed poor antibody responses, especially in the IgE fraction. When 24-day-old young adult worms were transferred from the brain of donor rats into the peritoneal cavity of sensitized rodents, peritoneal eosinophils predominantly adhered to the worm surfaces in vivo.
authors.affiliation: Department of Parasitology, Akita University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yoshimura
authors.forename: K
authors.initials: K
authors.lastname: Ishida
authors.forename: S
authors.initials: S
authors.lastname: Ishigooka
authors.forename: H
authors.initials: H
authors.lastname: Sugaya
authors.forename: M
authors.initials: M
authors.lastname: Kumagai
mesh_terms: D000801:Angiostrongylus / Q000276:immunology; D000818:Animals; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D007814:Larva / Q000276:immunology; D008297:Male; D009349:Nematode Infections / Q000276:immunology* / Q000517:prevention & control; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats; D011912:Rats, Inbred ACI; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains