title: Systemic lupus erythematosus in Indian children.
abstract: Twenty cases of systemic lupus erythematosus (SLE) in prepubertal children (less than 14 years of age) were seen over a period of 14 years. The male:female ratio was 1:2.3, and the mean age at onset was 9.37 years. Fever with joint involvement was the commonest presenting manifestation (60%), followed by nephrotic syndrome (25%). Notable clinical features included a high incidence of renal involvement (75%), significant hypertension (45%) and reversibility of acute renal failure (2 cases). The other organs and systems involved included: mucocutaneous manifestations (60%), cardiovascular system (30%), respiratory system (25%), neuropsychiatric manifestations (45%), and anemia (75%). Raynaud's phenomenon and thrombocytopenia were rare while leucopenia was not seen in a single patient. Immunological abnormalities noted were 100% positivity for antinuclear antibodies, and 87.5 and 75% positivity for antibodies to double-stranded and single-stranded DNA, respectively. Hypocomplementemia was seen in 75% of patients tested.
authors.forename: U S
authors.initials: US
authors.lastname: Ali
authors.forename: R B
authors.initials: RB
authors.lastname: Dalvi
authors.forename: R H
authors.initials: RH
authors.lastname: Merchant
authors.forename: K P
authors.initials: KP
authors.lastname: Mehta
authors.forename: A T
authors.initials: AT
authors.lastname: Chablani
authors.forename: S S
authors.initials: SS
authors.lastname: Badakere
authors.forename: H M
authors.initials: HM
authors.lastname: Bhatia
mesh_terms: D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000276:immunology; D003906:Developing Countries; D005260:Female; D006801:Humans; D007194:India; D008178:Lupus Erythematosus, Cutaneous / Q000175:diagnosis; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis*; D008181:Lupus Nephritis / Q000175:diagnosis; D008297:Male; D008875:Middle Aged
chemical_list: D000974:Antibodies, Antinuclear; D004247:DNA