title: Effects of angiotensin II and its fragments: angiotensin II(3-8)-hexapeptide and angiotensin II(4-8)-pentapeptide on retrieval in passive avoidance situation in rats chronically treated with ethanol.
abstract: Rats with impaired retrieval of passive avoidance behavior induced by chronic (9 weeks) administration of ethanol were studied. Angiotensin II (AII) and its fragments: AII(3-8) and AII(4-8), administered (icv, 2.0 micrograms) on the third day after ethanol withdrawal, neutralized the toxic effect of ethanol. Furthermore, the peptide AII(3-8) also gave an improvement in retrieval of the capability to perform simple behavioral tasks as it did in the control group in rats chronically pretreated with alcohol.
authors.affiliation: Department of Pharmacology, Medical Academy, Białystok, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Borawska
authors.forename: G
authors.initials: G
authors.lastname: Kupryszewski
authors.forename: B
authors.initials: B
authors.lastname: Witczuk
authors.forename: K
authors.initials: K
authors.lastname: Wiśniewski
mesh_terms: D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000809:Angiotensins / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000809:Angiotensins; D010446:Peptide Fragments; D000804:Angiotensin II; C012877:angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-; D000431:Ethanol; C022782:angiotensin pentapeptide