Lysosomal membrane stabilization by antiinflammatory drugs.
Lysosomal enzymes are important mediators of acute and chronic inflammatory diseases. The release of lysosomal enzymes into cytoplasm stimulate the inflammatory mediators like oxygen radicals, prostaglandins etc. Enfenamic acid, a fenamate, along with other antiinflammatory drugs, did not stabilize lysosomal membrane isolated from normal and activated phagocytic polymorphonuclear leucocytes of different species.
Rao
A B
AB
Sisodia
P
P
Sattur
P B
PB
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008247:Lysosomes / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects
D000893:Anti-Inflammatory Agents