Effect of fasting on monosodium glutamate-obese rats.
The effect of fasting was studied in lean and monosodium glutamate (MSG)-obese rats. Daily urinary urea excretion and body weight loss were studied before and during 21 days of fasting. MSG-obese rats showed reduced weight loss, higher total liver lipid content, and lower urea excretion during fasting, thus suggesting a higher capacity to spare body protein in comparison to controls. A significant decrease in retroperitoneal fat pad content was observed in both groups after 6 days of fasting (83% in the controls vs 35% in MSG-obese rats). These data suggest that the larger lipid stores of MSG-obese rats can explain their greater mean survival time after fasting.
Ribeiro
E B
EB
Departamento de Fisiologia, Escola Paulista de Medicina, Säo Paulo, Brasil.
Marmo
M R
MR
Andrade
I S
IS
Dolnikoff
M S
MS
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005215:Fasting; D005971:Glutamates / Q000494:pharmacology*; D050356:Lipid Metabolism; D008297:Male; D009765:Obesity / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012970:Sodium Glutamate / Q000494:pharmacology*; D014508:Urea / Q000097:blood; D015431:Weight Loss / Q000187:drug effects*
D001786:Blood Glucose; D005971:Glutamates; D014508:Urea; D012970:Sodium Glutamate