Esaprazole, a new antiulcer agent, stimulates gastric mucus output in the rat.
The effect of esaprazole, a new antiulcer compound endowed with gastro-protective properties, on rat gastric mucus was investigated after acute oral administration. Both soluble (luminal) and insoluble (parietal) mucus were examined for their content of: acidic and neutral glycoproteins; N-acetylneuraminic acid by colorimetric techniques; and fucose by HPLC methods. One hour after dosing (50-200 mg/kg) a 2-15-fold increase in soluble mucus and a 2-4-fold increase in insoluble mucus output were observed. Under the same experimental conditions, carbenoxolone (200 mg/kg, p.o.) caused a similar increase in gastric mucus output. These results demonstrate that quantitative changes in both luminal and parietal mucus occurred after orally dosed esaprazole: it is tempting to speculate that this effect might be responsible, at least in part, for the gastro-protective action of the drug.
Luzzani
F
F
Camillo Corvi S.p.A., Research Laboratories, Piacenza, Italy.
Clavenna
G
G
Zuccari
G
G
D000818:Animals; D000897:Anti-Ulcer Agents; D002229:Carbenoxolone / Q000494:pharmacology; D005260:Female; D005753:Gastric Mucosa / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism; D009093:Mucus / Q000378:metabolism; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000897:Anti-Ulcer Agents; D006023:Glycoproteins; D010879:Piperazines; C042123:esaprazole; D002229:Carbenoxolone