The beige mouse model for Mycobacterium avium complex (MAC) disease: optimal conditions for the host and parasite.
We extended our earlier studies to establish the beige (C57B1/6/bgJ/bgJ) mouse model for experimental acute infections with Mycobacterium avium complex (MAC). Optimal conditions of the host and the parasites have been determined. Mice bred at our center showed similar responses to those obtained from Jackson Laboratories, the original supplier. Both male and female mice showed similar responses, but older mice in both sexes showed less susceptibility than younger mice. Strain 101 of MAC showed remarkable consistency in its pathogenicity to beige mice, as evidenced by the distribution of colony forming unit (CFU) counts at various time points after intravenous challenge, in several experiments. CFU counts showed an association with the dose of challenge, and histopathological observations.
Gangadharam
P R
PR
Mycobacteriology Research Laboratories, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado.
Perumal
V K
VK
Farhi
D C
DC
LaBrecque
J
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D006790:Host-Parasite Interactions; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects / Q000472:pathogenicity; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D014774:Virulence
D000900:Anti-Bacterial Agents