title: Pre-operative and post-operative evaluation of circulating immune complexes in patients with gastric adenocarcinoma.
abstract: Circulating immune complexes (CICs) in the sera of patients with histologically proven adenocarcinoma of stomach were sequentially studied. Serial CICs levels, quantitated using a sensitive method F(ab')2 anti-C3 ELISA, were measured before surgery and in a post-operative follow up. CICs could be detected in 85% of the patients pre-operatively, while ten days after surgery positivity decreased to 71%. Thirty days after surgery, the mean CIC levels decreased significantly and positivity fell to 46%. The results indicate that removal of primary tumor mass results in a sharp decline of CIC levels.
authors.affiliation: Department of Immunology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, India.
authors.forename: M A
authors.initials: MA
authors.lastname: Siddiqi
authors.forename: M
authors.initials: M
authors.lastname: Salahuddin
authors.forename: O J
authors.initials: OJ
authors.lastname: Shah
authors.forename: N A
authors.initials: NA
authors.lastname: Wani
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology* / Q000601:surgery; D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008875:Middle Aged; D011184:Postoperative Period; D013274:Stomach Neoplasms / Q000276:immunology* / Q000601:surgery; D013997:Time Factors
chemical_list: D000936:Antigen-Antibody Complex