title: Osteonecrosis of vertebrae in a child with acute lymphocytic leukaemia during L-asparaginase therapy.
abstract: We report a child with acute lymphocytic leukaemia who developed simultaneous osteonecrosis of vertebrae and cerebral thrombosis during L-asparaginase therapy. Fibrinogen, antithrombin III and plasminogen were decreased. Fresh frozen plasma in addition to antithrombin III concentrates were used to replenish these haemostatic proteins. L-asparaginase induced coagulopathy may cause osteonecrosis.
authors.affiliation: Department of Paediatrics, University of Tsukuba, Ibaraki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hanada
authors.forename: Y
authors.initials: Y
authors.lastname: Horigome
authors.forename: M
authors.initials: M
authors.lastname: Inudoh
authors.forename: H
authors.initials: H
authors.lastname: Takita
mesh_terms: D000293:Adolescent; D000990:Antithrombin III / Q000032:analysis; D001215:Asparaginase / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D010020:Osteonecrosis / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D013122:Spinal Diseases / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000990:Antithrombin III; D001215:Asparaginase