In vivo interactions of NAN-190, a putative selective 5-HT1A antagonist, with ipsapirone.
The actions of NAN-190, a putative 5-HT1A antagonist, were assessed in rats. The selective 5-HT1A agent ipsapirone suppressed operant responding, but this effect was not antagonised by NAN-190, which suppressed responding itself in a dose-related manner, and had additive effects when administered with ipsapirone. These data do not support suggestions that NAN-190 is a 5-HT1A antagonist. NAN-190 may be a 5-HT1A partial agonist which can antagonise effects of full 5-HT1A agonists.
Deans
C
C
Department of Psychology, University of Liverpool, U.K.
Leathley
M
M
Goudie
A
A
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D010879:Piperazines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects; D012702:Serotonin Antagonists
D010879:Piperazines; D011743:Pyrimidines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C058895:1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine; C043077:ipsapirone