title: Wavelength dependence of histological, physical, and visible changes in chronically UV-irradiated hairless mouse skin.
abstract: Albino hairless mice (Skh: HR-1) exposed chronically to sub-erythemal doses of UV radiation display physical, visible and histological alterations. Using narrow bandwidth radiation covering the UV radiation spectrum from 280-380 nm, the wavelength dependence of these alterations was determined. The wavelength dependence spectra indicate that for all but one parameter measured (skin sagging), UV-B radiation is considerably more efficient than UV-A radiation in producing changes in the skin. However, in natural sunlight there is considerably more UV-A than UV-B radiation, providing the potential for UV-A to have a larger contribution to skin damage than UV-B. This argues in favor of using broad spectrum photoprotective agents to shield the skin adequately from UV-induced aging. The spectra were also used to develop potential associations among events by determining which events occur at similar wavelengths. There seems to be a correspondence between mouse visible skin wrinking (UV-B event) and two histological events: increase in glycosaminoglycans and alteration in collagen. There was no obvious correspondence among UV-A-induced events.
authors.forename: D L
authors.initials: DL
authors.lastname: Bissett
authors.forename: D P
authors.initials: DP
authors.lastname: Hannon
authors.forename: T V
authors.initials: TV
authors.lastname: Orr
mesh_terms: D000818:Animals; D003094:Collagen / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004549:Elastin / Q000528:radiation effects; D005260:Female; D006025:Glycosaminoglycans / Q000528:radiation effects; D051379:Mice; D008812:Mice, Hairless; D012867:Skin / Q000473:pathology / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D006025:Glycosaminoglycans; D003094:Collagen; D004549:Elastin