The effect of histamine on the induction of experimental autoimmune hemolytic anemia on OF1, BALB/c and SJL mice.
Erythrocyte autoantibodies can be elicited in mice by injection of rat red blood cells (RBC) which are cross-reactive with mouse RBC. In this report, we show that histamine injected in vivo delayed the production of autoantibodies among BALB/c and OF1 mice. In contrast, the induction of autoantibodies in SJL mice was not affected by histamine. Furthermore, histamine did not affect the production of anti-rat RBC. Cimetidine (anti-H2) but not diphenhydramine (anti-H1) inhibited the histamine effect.
Rigal
D
D
CRTS de Lyon-Gerland, Laboratoire d'Immunologie Cellulaire, France.
Baboin-Jaubert
M
M
Monier
J C
JC
D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis; D002927:Cimetidine / Q000494:pharmacology; D004155:Diphenhydramine / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D013045:Species Specificity
D001323:Autoantibodies; D002927:Cimetidine; D006632:Histamine; D004155:Diphenhydramine