Synthesis and anticonvulsant activity of N-phthaloyl GABA--a new GABA derivative.
A new gamma-aminobutyric acid derivative, N-phthaloyl GABA (P-GABA), was synthesised and its anticonvulsant activity was tested and compared with sodium valproate for efficacy against experimentally induced convulsions in mice. At a dose of 80 mg/kg, P-GABA rendered more protection than sodium valproate. ED50 of P-GABA and sodium valproate against bicuculline-induced convulsion was 96 and 301 mg/kg respectively in mice.
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D000818:Animals; D000927:Anticonvulsants; D008124:Locomotion; D008297:Male; D051379:Mice; D009126:Muscle Relaxation; D011817:Rabbits; D012640:Seizures / Q000188:drug therapy / Q000401:mortality; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D000927:Anticonvulsants; C063763:N-phthaloyl-4-aminobutyric acid; D005680:gamma-Aminobutyric Acid