title: [Development of resistance to the insecticide effect of juvenile hormone analog in Drosophila virilis: genetic and biochemical aspects].
abstract: The development of resistance to the insecticide effect of juvenile hormone analogue (AJH-I) in Drosophila was studied. It is found that under the AJH-I treatment metamorphosis in D. virilis was delayed and some insects died. Selection of resistant flies was performed using sublethal dose of AJH-I (viability was 8%). The selection at such dose of AJH-I resulted in an increase in the proportion of resistant flies up to 30% already by the F3, whereafter is fluctuated within the range of 24-46% for further 12 generations. The increase in resistance to the lethal effect of AJH-I was also accompanied by an increase in resistance to its teratogenic effects. An analysis of the kinetics of selection has shown that the AJH-I resistance is controlled by more than one gene. It is established that the increase in resistance is associated with selection of individuals having high activity of juvenile hormone esterase.
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Raushenbakh
authors.forename: I S
authors.initials: IS
authors.lastname: Lukashina
authors.forename: N I
authors.initials: NI
authors.lastname: Iaroshenko
authors.forename: V A
authors.initials: VA
authors.lastname: Raldugin
authors.forename: R I
authors.initials: RI
authors.lastname: Salganik
mesh_terms: D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors; D004330:Drosophila / Q000187:drug effects / Q000235:genetics*; D007305:Insecticide Resistance / Q000235:genetics*; D007605:Juvenile Hormones / Q000494:pharmacology*; D063086:Organothiophosphates / Q000494:pharmacology; D012641:Selection, Genetic
chemical_list: D007605:Juvenile Hormones; D063086:Organothiophosphates; C009525:tributyl thiophosphate; D002265:Carboxylic Ester Hydrolases; C038003:juvenile hormone esterase
vernacular_title: Razvitie rezistentnosti k insektitsidnomu deĭstviiu analoga iuvenil'nogo gormona u Drosophila virilis: geneticheskie i biokhimicheskie aspekty.