Effect of verapamil on chemiluminescence of peripheral blood neutrophils during hemodialysis in chronic uremic patients.
Luminol-dependent chemiluminescence of resting and opsonized zymosan-activated neutrophils isolated from the peripheral blood was determined in 10 chronic uremic patients during early period of hemodialysis without verapamil or preceded by verapamil injection. Verapamil was found to diminish depression of neutrophil chemiluminescence both at rest and following activation with opsonized zymosan. The drug also diminished transient hemodialysis neutropenia. The results seem to indicate that verapamil may exert beneficial effects on inflammatory reactions induced by hemodialysis in chronic uremics.
Pawlicki
L
L
2nd Department of Internal Medicine, Military Medical Academy, Lódź.
Tchórzewski
H
H
Trznadel
K
K
Luciak
M
M
Kantorski
J
J
Pokoca
L
L
D000328:Adult; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D002908:Chronic Disease; D005260:Female; D005609:Free Radicals; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D006435:Renal Dialysis; D014700:Verapamil / Q000494:pharmacology*
D005609:Free Radicals; D014700:Verapamil; D010100:Oxygen