title: [The effect of molsidomine on bicycle ergometry in patients with stable angina pectoris].
abstract: The authors investigated the effect of a single dose of 4 mg molsidomine on the course of bicycle ergometry. This effect was compared with that of 120 mg isosorbide dinitrate retard and with placebo. Isosorbide dinitrate in this large dose significantly protracted the period before angina pectoris developed after exercise, it significantly reduced the duration of stenocardias, significantly increased the total work output, significantly prolonged the period before a reduction of the ST segment occurred on the ECG and significantly reduced the values of reduction of the ST segments. Moisidomine in medium doses significantly protracted the period before angina pectoris developed after exercise and significantly increased the total work output. After comparison of the described results with those of investigations where smaller doses of isosorbide dinitrate were used, the authors assume that after increasing the dose of molsidomine its effect will be comparable with large nitrate doses.
authors.forename: P
authors.initials: P
authors.lastname: Rotrekl
authors.forename: Z
authors.initials: Z
authors.lastname: Lupínek
authors.forename: J
authors.initials: J
authors.lastname: Meluzín
authors.forename: F
authors.initials: F
authors.lastname: Rysavý
authors.forename: Z
authors.initials: Z
authors.lastname: Lupínková
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D005080:Exercise Test / Q000187:drug effects*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D008981:Molsidomine / Q000494:pharmacology*
chemical_list: D008981:Molsidomine; D007548:Isosorbide Dinitrate
vernacular_title: Vliv molsidominu na průbĕh bicyklové ergometrie u nemocných se stabilní anginou pectoris.