title: Localization of interleukin 6 mRNA in human tonsils by in situ hybridization.
abstract: We have investigated which areas produce interleukin 6 (IL 6) in human tonsils. This growth factor is required for the terminal differentiation of B lymphocytes into plasmocytes. Using 35S-labeled IL 6 cDNA we demonstrated IL 6 gene expression over various areas of the tonsils, with consistent exception of the follicles, by in situ hybridization. It is, therefore, proposed that B cells are stimulated during their migration out of the follicles.
authors.affiliation: Institute of Histology, University of Liège, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Bosseloir
authors.forename: E L
authors.initials: EL
authors.lastname: Hooghe-Peters
authors.forename: E
authors.initials: E
authors.lastname: Heinen
authors.forename: N
authors.initials: N
authors.lastname: Cormann
authors.forename: C
authors.initials: C
authors.lastname: Kinet-Denoël
authors.forename: L
authors.initials: L
authors.lastname: Vanhaelst
authors.forename: L
authors.initials: L
authors.lastname: Simar
mesh_terms: D001402:B-Lymphocytes / Q000502:physiology*; D015342:DNA Probes; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D014066:Palatine Tonsil / Q000166:cytology / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D015342:DNA Probes; D015850:Interleukin-6; D012333:RNA, Messenger