[Experimental and clinical studies of the effect of dahuang zhechong wan on hyperlipemia].
Experimental and clinical researches were done for the purpose of that to treat the hyperlipemia with Dahuang Zhechong Wan (DHZCW). The patients of primary hyperlipemia were divided into two groups. One group was treated with DHZCW, the other with inositol nicotinate as control. DHZCW could reduce the serum total cholesterol (0.05 less than P less than 0.2), triglyceride (P less than 0.05), the blood viscosity (P less than 0.01), reductive viscosity (P less than 0.001) and fibrinogen (0.05 less than P less than 0.2). No significant change of the other item of hemorheology, HDL-c and the subfraction were observed. No significant differential effect between those two groups. The experimental hyperlipidemic model was made by feeding cholesterol and axungia on rabbits. The results showed that DHZCW could reduce the serum total cholesterol (P less than 0.05), triglyceride (P less than 0.05), beta-LP (P less than 0.01), the blood viscosity (P less than 0.05) and plasma viscosity (P less than 0.05), but no significant effect on HDL-c and its subfraction, ESR, index of erythrocytic deformation and hematocrit. DHZCW could change the viscosity of blood of hyperlipemia and reduce the total cholesterol, triglyceride and fibrinogen of the blood. It might have some beneficial effects on atherosclerosis and prevent ischemic cardiovascular and cerebrovascular diseases.
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D000328:Adult; D000368:Aged; D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D008076:Cholesterol, HDL / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011817:Rabbits
D008076:Cholesterol, HDL; D004365:Drugs, Chinese Herbal