Synthesis and properties of oligodeoxyribonucleotides containing N6-methoxyadenine.
Oligodeoxyribonuclotides containing N6-methoxyadenine (mo6A), a promutagenic base, were synthesized. The Tm values and thermodynamic parameters for double strand formation of d(CCTGGTAmo6ACAGGTCC) have been measured. The order of the base-pair stability was A-T greater than mo6A-C approximately equal to mo6A-T greater than A-C.
Nishino
H
H
Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
Ono
A
A
Matsuda
A
A
Ueda
T
T
D000225:Adenine / Q000031:analogs & derivatives*; D001483:Base Sequence; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D013816:Thermodynamics
D009838:Oligodeoxyribonucleotides; D000225:Adenine