[The effect of tetracycline and silibore on lipid peroxidation in the liver od rats of various age].
As shown by accumulation of malonic dialdehyde and chemiluminescence rate monitoring tetracycline activated both NADPH- and ascorbate-dependent lipid peroxidation in liver tissue of 1, 3, 12 and 24 months old rats. The most distinct induction of lipid peroxidation was observed in old animals, which appears to occur due to a decrease in efficiency of NADPH-GSH-dependent enzymatic antioxidant system. Silibore prevented the stimulating effect of tetracycline on enzymatic and nonenzymatic lipid peroxidation, being apparently involved in hepatoprotective effect.
Lemeshko
V V
VV
Dorkina
E G
EG
Nikitchenko
Iu V
IuV
Vasilenko
Iu K
IuK
D000375:Aging; D000818:Animals; D005419:Flavonoids / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008163:Luminescent Measurements; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013752:Tetracycline / Q000037:antagonists & inhibitors / Q000633:toxicity*
D005419:Flavonoids; C061938:silibor; D008315:Malondialdehyde; D013752:Tetracycline
Vliianie tetratsiklina i silibora na perekisnoe okislenie lipidov pecheni krys raznogo vozrasta.