[Experimental study on doxorubicin as an adjunct to glaucoma surgery].
11 drugs were screened in vitro for their inhibitory effect on rabbit subconjunctival fibroblasts. Doxorubicin was further observed in animal models of subconjunctival scars caused by imbedded silk thread for its inhibitory action in vivo. Doxorubicin was found to be effective, the ID50 being 0.007 mg/L. The average thickness of subconjunctival fibroblasts around the thread in the instillation group and the injection group was 11.1 +/- 1.14 microns and 3.59 +/- 0.65 microns respectively, both significantly thinner than that in the control group, 26.98 +/- 1.86 microns. When 0.08 mg of tritiated doxorubicin was injected subconjunctivally, the concentration in aqueous humor was over the ID50 in vitro, while the concentration in vitreous did not exceed the toxic level.
Ren
J M
JM
D000818:Animals; D002921:Cicatrix / Q000188:drug therapy; D003228:Conjunctiva / Q000187:drug effects*; D004317:Doxorubicin / Q000493:pharmacokinetics / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects; D005901:Glaucoma / Q000601:surgery; D011817:Rabbits
D004317:Doxorubicin