title: Renal urea clearance in normal and adrenalectomized rats after exercise.
abstract: In groups of male Wistar rats, blood level, urinary excretion of urea, and renal urea clearance were determined in resting conditions or during 48-60 h after swimming for 30 min with an additional load of 10% of body weight as well as after swimming for 3 or 10 h without additional load. Both types of swimming exercise caused a significant increase in the blood level, urinary excretion, and renal clearance of urea. After 10-h swimming, the increase of renal urea clearance was observed only from the second period (0-12 h) of urine collection. In this type of exercise, an elevation of blood level of corticosterone was obtained after 6-h restitution. The increased urinary excretion and renal urea clearance persisted for a longer time than was necessary for the normalization of the blood level. A significant rise in blood urea level and a drop in renal urea clearance occurred after adrenalectomy. In adrenalectomized rats, increased urea excretion and renal clearance were observed 12-24 h after 3-h swimming, but the level of renal clearance obtained in sedentary normal rats was not achieved. The blood level of urea did not increase. This suggested that the glucocorticoids play a role both in urea formation during exercise and in its elevated renal clearance after exercise.
authors.affiliation: Department of Sports Physiology, Tartu State University, Estonian, S.S.R.
authors.forename: L
authors.initials: L
authors.lastname: Litvinova
authors.forename: A
authors.initials: A
authors.lastname: Viru
authors.forename: T
authors.initials: T
authors.lastname: Smirnova
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D007668:Kidney / Q000502:physiology*; D008297:Male; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming; D014508:Urea / Q000097:blood / Q000652:urine*
chemical_list: D014508:Urea