[The effect of certain substances on changes in the expression of class II HLA antigens].
With the aid of the RIA method, the authors found that the stimulation of T-lymphocytes by means of PWM lectin is linked to the expressivity of HLA antigens of class II on their surface. A simultaneous addition of indomethacin, tetracycline, coreton, hydrocortisone and novozir was decreasing the expressivity of the Ia antigens and, at the same time inhibited the lymphocyte proliferation. The growth factor for T (IL-2) lymphocytes was increasing the expressivity of HLA-DR antigens in the cells even without a previous stimulation by mitogen. Glucan, serous thymic factor, natrium salicylicum, hippuric acid had no effect on the expressivity of the HLA antigens of class II.
Munozová
H
H
Buc
M
M
Russ
G
G
D006681:HLA-D Antigens / Q000032:analysis*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007741:Labetalol / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D011863:Radioimmunoassay; D013752:Tetracycline / Q000494:pharmacology; D015038:Zineb / Q000494:pharmacology
D006681:HLA-D Antigens; D013752:Tetracycline; D007741:Labetalol; D006854:Hydrocortisone; D015038:Zineb; D007213:Indomethacin
Zmena expresivity antigénov HLA triedy II pod vplyvom vybraných látok.