title: Effect of extract of Hirudo Medicinalis L. against adherence of calcium oxalate crystals to acid-injured bladder mucosa.
abstract: The effect of extract of Hirudo Medicinalis L. on preventing the adhesion of calcium oxalate crystals to 0.1 M hydrochloric acid-injured bladder urothelium of the rat was studied. It was found that in this species the extract coated to the bladder mucosa after it was instilled into the chemically injured bladder; and the adhesion of calcium oxalate crystals was prevented. In regard to the anti-adhesion property the Hirudo extract appears more effective than heparin, a documented glycosaminoglycan.
authors.affiliation: Department of Urology, 2nd Affiliated Hospital, Lanzhou Medical College, Gansu, People's Republic of China.
authors.forename: G D
authors.initials: GD
authors.lastname: Liu
authors.forename: J Y
authors.initials: JY
authors.lastname: He
authors.forename: G T
authors.initials: GT
authors.lastname: Chang
authors.forename: X A
authors.initials: XA
authors.lastname: Yu
authors.forename: G P
authors.initials: GP
authors.lastname: Zhong
authors.forename: S M
authors.initials: SM
authors.lastname: Niu
authors.forename: X Q
authors.initials: XQ
authors.lastname: Shi
authors.forename: H F
authors.initials: HF
authors.lastname: Yan
mesh_terms: D000268:Adhesiveness; D000818:Animals; D002129:Calcium Oxalate; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology; D006851:Hydrochloric Acid; D008297:Male; D008855:Microscopy, Electron, Scanning; D051381:Rats; D001743:Urinary Bladder / Q000187:drug effects*
chemical_list: D004365:Drugs, Chinese Herbal; D002129:Calcium Oxalate; D006493:Heparin; D006851:Hydrochloric Acid