title: [Karyotype study of blood lymphocytes in sarcoidosis].
abstract: Among 31 patients presenting with pulmonary sarcoidosis, two had abnormalities of their blood lymphocyte karyotypes. The karyotype of the first patient showed an initially high percentage of non-specifically broken chromosomes. The second patient, who had been treated with azathioprine (AZ) one year previously, had an apparently balanced translocation 46 XX, t (11; 11) (p 12, p 14) in blood T lymphocytes but not in skin fibroblast culture. Various hypotheses can be discussed to explain this translocation: a direct toxic effect of AZ or a genomic abnormality depending upon sarcoidosis and possibly revealed by AZ. It is important to note that this translocation concerned a region of the short arm of chromosome 11, where Harvey ras I and parathormone genes have been located.
authors.affiliation: Service du Pr M. Perrin-Fayolle, Centre hospitalier Lyon-Sud, Pierre-Bénite.
authors.forename: Y
authors.initials: Y
authors.lastname: Pacheco
authors.forename: C
authors.initials: C
authors.lastname: Charrin
authors.forename: L
authors.initials: L
authors.lastname: Villa
authors.forename: G
authors.initials: G
authors.lastname: Cozon
authors.forename: F
authors.initials: F
authors.lastname: Gormand
authors.forename: D
authors.initials: D
authors.lastname: Piperno
authors.forename: N
authors.initials: N
authors.lastname: Biot
authors.forename: R
authors.initials: R
authors.lastname: Harf
authors.forename: D
authors.initials: D
authors.lastname: Gindre
authors.forename: M
authors.initials: M
authors.lastname: Perrin-Fayolle
mesh_terms: D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005796:Genes / Q000187:drug effects; D006801:Humans; D007621:Karyotyping; D008171:Lung Diseases / Q000097:blood* / Q000188:drug therapy / Q000235:genetics; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000097:blood* / Q000188:drug therapy / Q000235:genetics
chemical_list: D001379:Azathioprine
vernacular_title: Etude caryotypique des lymphocytes sanguins dans la sarcoïdose.