The effect of scoparone, a coumarin derivative isolated from the Chinese crude drug Artemisiae capillaris flos, on the heart.
In the present study, scoparone isolated from Artemisia Capillaris Flos has been investigated to determine its pharmacological properties on the heart. Scoparone was found to cause the increase in coronary flow and heart rate, but did not affect cardiac output, left ventricular pressure or left ventricular work in the isolated perfused heart. Scoparone at 25 mg/kg and 50 mg/kg, p.o. had a marked inhibitory effect on the ST wave depression. Consequently it is suggested that scoparone has antianginal action.
Yamahara
J
J
Kobayashi
G
G
Matsuda
H
H
Katayama
T
T
Fujimura
H
H
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004569:Electroencephalography; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000959:Antihypertensive Agents; D003374:Coumarins; D004365:Drugs, Chinese Herbal; C018145:scoparone