title: Quantitative determination of naltiazem in human plasma by gas chromatography/mass spectrometry.
abstract: A gas chromatographic/mass spectrometric procedure has been developed for the quantification of a diltiazem analog, naltiazem, in human plasma. The assay utilizes an extraction at neutral pH with hexane:ethylene dichloride:methyl-t-butyl ether (70:20:10), selective ion monitoring, methane or ammonia positive chemical ionization mass spectrometry and stable isotope dilution. The method has been used to analyze plasma concentrations of naltiazem in clinical samples over a range of 2-200 ng ml-1, using 1 ml of plasma.
authors.affiliation: Department of Drug Metabolism, Hoffman-La Roche Inc., Nutley, New Jersey 07110-1199.
authors.forename: P P
authors.initials: PP
authors.lastname: Davis
authors.forename: N
authors.initials: N
authors.lastname: Choma
authors.forename: T
authors.initials: T
authors.lastname: Crews
authors.forename: E K
authors.initials: EK
authors.lastname: Fukuda
mesh_terms: D002121:Calcium Channel Blockers / Q000097:blood* / Q000493:pharmacokinetics; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013841:Thiazepines / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D002121:Calcium Channel Blockers; D013841:Thiazepines; C062703:naltiazem