A human adenolymphoma showing the chromosomal aberrations del (7)(p12p14-15) and t(11;19)(q21;p12-13).
A clearly benign parotid tumor, an adenolymphoma, was studied cytogenetically using short-term cultured material. The first preparation showed only a normal stemline. The two subsequent preparations were both characterized by a pseudodiploid stemline with the karyotype 46,XY,del(7) (p12p14-15), t(11;19) (q21;p12-13). The 11;19 translocation was identical to that characterizing the abnormal stemline of the only previously studied case. These suggestive observations give rise to several questions, in particular whether or not all adenolymphomas contain cells with this specific reciprocal translocation and, in cases with the translocation, its implications at the molecular level.
Mark
J
J
Department of Pathology and Cytogenetics, Central Hospital, Skövde, Sweden.
Dahlenfors
R
R
Stenman
G
G
Nordquist
A
A
D000235:Adenolymphoma / Q000235:genetics* / Q000601:surgery; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D002888:Chromosomes, Human, Pair 19; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000235:genetics* / Q000601:surgery; D014178:Translocation, Genetic