[Structural changes in the rat cerebral cortex induced by alcohol in combination with aldehyde dehydrogenase inhibitors].
The cerebral parietal cortex in rats subjected to an acute (single) and subacute (for 5 days) ethanol effect in combination with aldehyde dehydrogenase (AldDG) (enzymes classification 1.2.1.3 AldDG) inhibitors--disulfiram and cyanamide--has been investigated histochemically and electron microscopically. The inhibitors mentioned produce an essential decrease of AldDG activity in the cerebral cortex; it remains in some structures even 6 days after their single administration. Against the background of AldDG inhibitors alcohol produces more noticeable structural disorders in the cerebral cortex, they are possibly connected with accumulation of a highly toxic ethanol metabolite-acetaldehyde--in blood and with its easy penetration into the brain. This demonstrates an important role of AldDG in protection of the brain from alcoholic (aldehydic) lesions, as well as a peculiar danger for the brain of ethanol in combination with inhibitors of this enzyme.
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D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors*; D000818:Animals; D001284:Atrophy / Q000139:chemically induced; D003484:Cyanamide / Q000008:administration & dosage / Q000633:toxicity*; D003486:Cyanides / Q000633:toxicity*; D004221:Disulfiram / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure*; D010296:Parietal Lobe / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D051381:Rats
D003486:Cyanides; D000431:Ethanol; D003484:Cyanamide; D000444:Aldehyde Dehydrogenase; D004221:Disulfiram
Strukturnye izmeneniia v kore mozga krys, vyzyvaemye alkogolem v sochetanii s ingibitorami a'ldegiddegidrogenazy.