[Studies of tryptophan metabolism in cancer of the urinary bladder].
In 100 patients suffering from urinary bladder cancer (pTA-4, Nx, M0-1, G0-3) we created an oral tryptophan load administering 5 g of L-type tryptophan. Thereafter the amount of both xanthurenic acid and kynurenin was determined quantitatively in the 24-hour urine. 16 patients revealed pathological test results and excretion pattern of tryptophan metabolites via kynurenin were similar to vitamin B6-dependent xanthurenic aciduria both in its homocygotic and heterocygotic pattern. It has not been possible to prove a direct correlation between xanthurenic aciduria and urinary bladder cancer. However, xanthurenic aciduria may be of significance as a risk factor in the etiopathogenesis of urinary bladder cancer.
Wich
H
H
Urologische Klinik, Bezirkskrankenhauses Heinrich Braun Zwickau.
Grimm
U
U
Knapp
A
A
D006801:Humans; D007737:Kynurenine / Q000652:urine*; D012307:Risk Factors; D014364:Tryptophan / Q000493:pharmacokinetics; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000652:urine; D014977:Xanthurenates / Q000652:urine*
D014977:Xanthurenates; D007737:Kynurenine; C028330:xanthurenic acid; D014364:Tryptophan
Tryptophanstoffwechseluntersuchungen beim Harnblasenkarzinom.