[The role of adherent cells in supporting natural cytotoxicity reactions].
The cytotoxic activity of natural killer (NK) cells and interferon-alpha (IFN-alpha) production by NK cells were studied. It was shown that in healthy donors adherent cells (AC) play an important role in reactions of natural cytotoxicity: they provide the main IFN production in the NK system. AC suppresses the cytotoxic activity of NK cells in patients with scleroderma and AC has a high cytotoxic activity in patients with multiple sclerosis. The role of AC in appearance and development of NK immunodeficiency in these pathologies was discussed.
Sorokin
A M
AM
Chenëv
S B
SB
Koval'chuk
L V
LV
D000328:Adult; D002448:Cell Adhesion / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000032:analysis; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology; D012595:Scleroderma, Systemic / Q000276:immunology
D007370:Interferon Type I
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