[Benzonitrile and derivatives. Synthesis and pharmacological study of alkyl para-cyanophenoxy alkanoates on the central nervous system].
The results obtained by the pharmacological study of alkyl para-cyanophenoxy alkanoates seem to indicate that these derivatives present a sedative effect on the central nervous system. This activity increases with the number of methyl groups substituted, on ethyl para-cyanophenoxy acetate (except the motricity composent), most probably because of an increase in lipophily and therefore in the fixation on the central nervous system.
Kirkiacharian
S
S
Goma
J R
JR
Cheav
S L
SL
Bretaudeau
J
J
Foussard-Blanpin
O
O
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000494:pharmacology; D002492:Central Nervous System Depressants; D004347:Drug Interactions; D006993:Hypnotics and Sedatives; D008297:Male; D051379:Mice; D009570:Nitriles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
D002491:Central Nervous System Agents; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D009570:Nitriles; C014356:benzonitrile
Benzonitrile et dérivés. Synthèse et étude pharmacologique de para-cyanophénoxy-alcanoates d'alkyle sur le système nerveux central.