[The hypothalamo-hypophyseal neurosecretory system in rats with hereditary arterial hypertension].
Histochemical and cytometrical analysis of the peptidergic Gomori-positive or hypothalamo-hypophyseal neurosecretory system (HHNS) was made in the 3 strains of rats: spontaneously hypertensive rats (SHR), rats with inherited stress-induced arterial hypertension (ISIAH), and normotensive Wistar rats. A significant increase in the production of the peptide neurohormones by the supraoptic nuclei was found in two hypertensive strains (SHR and ISIAH) compared to the normotensive Wistar rats. For ISIAH-rats, the excretion of neurohormones was more pronounced in the region of median eminence, and for SHR--in the posterior hypophyseal lobe. It was concluded that hyperfunction of HHNS can play an important role in the hypertension development in two strains or rats studied.
Iurisova
M N
MN
Markel'
A L
AL
Naumenko
E V
EV
D000818:Animals; D006651:Histocytochemistry; D006973:Hypertension / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009479:Neuropeptides / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY
D009479:Neuropeptides
Gipotalamo-gipofizarnaia neĭrosekretornaia sistema u krys s nasledstvenno obuslovlennoĭ arterial'noĭ gipertenzieĭ.