D-lactate dehydrogenase. Substrate specificity and use as a catalyst in the synthesis of homochiral 2-hydroxy acids.
This note compares the substrate specificity of D-lactate dehydrogenase (D-LDH, EC 1.1.1.28) to that of L-lactate dehydrogenase (L-LDH, EC 1.1.1.27), illustrates three procedures that use D-LDH in synthesis and two methods for recycling NADH, and provides experimental details illustrating the use of D-LDH in organic synthesis.
Simon
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Department of Chemistry, Harvard University, Cambridge, MA 02138.
Plante
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Whitesides
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D002384:Catalysis; D004852:Epoxy Compounds / Q000138:chemical synthesis; D006880:Hydroxy Acids / Q000138:chemical synthesis*; D006885:Hydroxybutyrates / Q000138:chemical synthesis; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D007773:Lactates / Q000138:chemical synthesis; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013379:Substrate Specificity
D004852:Epoxy Compounds; D006880:Hydroxy Acids; D006885:Hydroxybutyrates; D007773:Lactates; D009243:NAD; C027488:1,2-epoxybutane; C005434:atrolactic acid; D007770:L-Lactate Dehydrogenase; C031570:2-hydroxybutyric acid