Comparison of colchicine toxicity on different dysmyelinating mutant models.
The administration of colchicine to dysmyelinating mutant mice may serve as an in vivo pharmacological tool for the study of the mechanisms involved in the formation of the myelin sheath. The study of the acute toxicity of colchicine in these mutants demonstrated that male animals were much more sensitive than female animals. All of the mutants and their controls were also more resistant to colchicine than the Swiss strain usually used in toxicity studies.
Urtizberea
M
M
INSERM U 26 Hôpital Fernand Widal, Paris, France.
Bourre
J M
JM
Debray
M
M
Scherrmann
J M
JM
D000818:Animals; D003078:Colchicine / Q000008:administration & dosage / Q000633:toxicity*; D003627:Data Interpretation, Statistical; D007928:Lethal Dose 50; D051379:Mice; D008818:Mice, Neurologic Mutants; D009186:Myelin Sheath / Q000502:physiology*; D013045:Species Specificity
D003078:Colchicine