title: Effect of oral potassium on urinary kallikrein excretion in essential hypertension.
abstract: Urinary kallikrein and potassium were excreted in parallel in not only static but also dynamic sodium states. Oral potassium load stimulated the release of urinary kallikrein in normotensive subjects and WHO stage I essential hypertensive patients. Stage II essential hypertensive patients had the lowest value of basal level of urinary kallikrein and showed no increase in urinary kallikrein by oral potassium load. These results suggest that the functional activity of renal kallikrein-kinin system decreases with the development of essential hypertension.
authors.affiliation: 2nd Department of Internal Medicine, Ehime University School of Medicine, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Hiwada
authors.forename: T
authors.initials: T
authors.lastname: Kokubu
authors.forename: Y
authors.initials: Y
authors.lastname: Imamura
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000450:Aldosterone / Q000097:blood / Q000652:urine; D006801:Humans; D006973:Hypertension / Q000652:urine*; D007610:Kallikreins / Q000652:urine*; D008875:Middle Aged; D011188:Potassium / Q000008:administration & dosage / Q000494:pharmacology* / Q000652:urine; D012016:Reference Values; D012964:Sodium / Q000652:urine
chemical_list: D000450:Aldosterone; D012964:Sodium; D007610:Kallikreins; D011188:Potassium