title: Reversibility of primary pulmonary hypertension with vasodilator, anticoagulant and nocturnal oxygen therapy.
abstract: Successful vasodilator therapy of a 19 year old woman with primary pulmonary hypertension is described. Long-term home oxygen therapy during sleep (2 1/min, 8 hours) in combination with vasodilator drugs (prazosin 2 mg and long-acting ISDN 20 mg bid) and an anticoagulant (ticlopidine 100 mg bid) brought significant reduction of pulmonary artery pressure and a rise of cardiac output 3 years later. This combination therapy may be effective in selected patients with primary pulmonary hypertension.
authors.affiliation: Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kanemoto
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Shiina
authors.forename: Y
authors.initials: Y
authors.lastname: Goto
mesh_terms: D000293:Adolescent; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000628:therapy*; D007548:Isosorbide Dinitrate / Q000627:therapeutic use*; D010102:Oxygen Inhalation Therapy; D011224:Prazosin / Q000627:therapeutic use*; D013988:Ticlopidine / Q000627:therapeutic use*
chemical_list: D007548:Isosorbide Dinitrate; D013988:Ticlopidine; D011224:Prazosin