[Primary hyperparathyroidism and peptic ulcer].
The prevalence of peptic ulcer disease was retrospectively analysed in 35 patients affected by primary hyperparathyroidism consecutively observed from 1977 through 1987. Eight of the examined patients (22.8%) had peptic ulcer (7 duodenal and 1 gastric ulcer), that in five cases (14%) represented the first clinical manifestation of the endocrine disease. A Zollinger-Ellison syndrome was demonstrated in three cases (8.5% of the total series, 37% of the patients with ulcer). There was no difference in calcium, gastrin and parathormone serum level between patients with and without ulcer, excluding patients with Zollinger-Ellison syndrome. These data confirm the high prevalence of peptic ulcer disease in hyperparathyroidism, but the mechanism causing this association remains to be elucidated.
Gasparoni
P
P
Divisione Medica I, Ospedale Civile, Montebelluna.
Caroli
A
A
Sardeo
G
G
Maschio
S
S
Lo Giudice
C
C
Fioretti
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000097:blood; D005260:Female; D005755:Gastrins / Q000097:blood; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010437:Peptic Ulcer / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology
D005755:Gastrins; D010281:Parathyroid Hormone; D002118:Calcium
Iperparatiroidismo primitivo ed ulcera peptica.