[Interaction of neuroblastoma C 1300 N18 cells with liposomes and intermembrane metabolism of lipids].
The methods of isotopic and fluorescent labels have shown that interaction of cells of neuroblastoma S 1300 N 18 with small one-layer neutral liposomes prepared of the egg phosphatidyl choline with the addition of different amounts of cholesterol is realized by two mechanisms: the transmembrane transfer of cholesterol by the concentration gradient and membrane lipid metabolism proper, the ratios of cholesterol phospholipids in the biological and artificial membranes being equal. A dependence is established of the neuroblastoma cell viability on the activity of the cholesterol membrane metabolism. A problem on the mechanism which causes the death of cells during the interaction with phosphatidyl-cholesterol liposomes is under discussion.
Volkov
G L
GL
Gula
N M
NM
Govseieva
N M
NM
Artemenko
I P
IP
Perederiĭ
O F
OF
Khomutovs'kiĭ
O A
OA
D001692:Biological Transport; D002470:Cell Survival; D002784:Cholesterol / Q000378:metabolism; D006801:Humans; D008081:Liposomes / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism*; D009447:Neuroblastoma / Q000378:metabolism* / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000378:metabolism / Q000473:pathology
D008081:Liposomes; D008563:Membrane Lipids; D002784:Cholesterol
Vzaiemodiia klitin neĭroblastomi C 1300 N18 iz liposomami ta mizhmembranniĭ obmen lipidiv.