[The effect of alkyl-lysophospholipids and membrane potentials, proliferation and migration of isolated calf aorta endothelial cells].
Cancerostatical active synthetic alkyl-lysophospholipids were examined with regard to their effects on membrane potential, proliferation and migration of isolated endothelial cells. In sublytic concentrations all alkyl-lysophospholipids tested caused a hyperpolarization of the membrane of endothelial cells. The effect of alkyl-lysophospholipids on proliferation of endothelial cells was dependent on the serum supplement. The migration of endothelial cells was strongly inhibited by 1-O-octadecyl-2-O-methyl-glycero-phosphocholine. Possible mechanisms of action are discussed.
Mende
S
S
Sektion Pharmazie, Ernst-Moritz-Arndt-Universität Greifswald, DDR, Berlin.
Teuscher
E
E
Windeck
I
I
Lichtnow
K H
KH
Nuhn
P
P
Brachwitz
H
H
D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology / Q000187:drug effects; D002417:Cattle; D002465:Cell Movement / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D008246:Lysophospholipids / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects
D008246:Lysophospholipids
Zum Einfluss von Alkyllysophospholipiden auf Membranpotential, Teilung und Migration von isolierten Kälberaortenendothelzellen.