Brain white-matter lesions and psychosis.
In a prospective study of late-life onset psychosis, five of the first 27 patients studied had extensive white-matter lesions demonstrated by MRI and/or CT. None of 60 age-matched psychiatrically healthy controls demonstrated such lesions. All five patients had a mild dementia and a frontal behavioural syndrome. In addition, every patient performed poorly on neuropsychological tests of frontal function. Dysfunction of the frontal cortex associated with white-matter lesions appears to contribute to the clinical picture of some cases of late-life psychosis.
Miller
B L
BL
Department of Neurology, Harbor-UCLA Medical Center, Torrance 90509.
Lesser
I M
IM
Boone
K
K
Goldberg
M
M
Hill
E
E
Miller
M H
MH
Benson
D F
DF
Mehringer
M
M
D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000175:diagnosis; D001921:Brain / Q000473:pathology*; D003704:Dementia / Q000175:diagnosis*; D015161:Dementia, Multi-Infarct / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis*; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000175:diagnosis; D014057:Tomography, X-Ray Computed