title: [The development and use of nitrate therapy].
abstract: The authors describe the development of nitrates from substances of the first generation (nitroglycerin and isosorbide dinitrate) to the use of mononitrates. They explain the mechanism of their action, the haemodynamic effects and the phenomenon of nitrate tolerance. The authors present also their own experience with nitrate therapy in angina pectoris and heart failure based on haemodynamic monitoring and recommend its rational use.
authors.forename: M
authors.initials: M
authors.lastname: Stejfa
authors.forename: J
authors.initials: J
authors.lastname: Vítovec
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D006331:Heart Diseases / Q000188:drug therapy; D006801:Humans; D009566:Nitrates / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D009566:Nitrates
vernacular_title: Vývoj a uzití nitrátové terapie.