[The effect of experimental infarct and emotional-pain stress on the endothelium-dependent reactions of the isolated rat aorta].
Emotional-nociceptive stress, stress induced with a myocardial infarction, and stress following sham operation increased the effect of endothelium on the force and velocity of the smooth muscle contraction. Within 2 hrs after stress and 3 hrs after the coronary artery ligation, a considerable drop occurred in the rat arterial pressure followed by a facilitation of the aorta endothelium-dependent relaxation. Both these parameters were restored to the control level within 24 hrs. The facilitation of the endothelium-dependent relaxation of vascular wall seems to play a role in the drop of the vessels tone, in decrease of arterial pressure and, finally, in development of the cardiogenic shock in myocardial infarction in humans.
Manukhina
E B
EB
Lapshin
A V
AV
Ustinova
E E
EE
Meerson
F Z
FZ
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D009203:Myocardial Infarction / Q000503:physiopathology*; D009638:Norepinephrine / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000503:physiopathology*
D000109:Acetylcholine; D009638:Norepinephrine
Vliianie éksperimental'nogo infarkta i émotsional'no-bolevogo stressa na éndoteliĭzavisimye reaktsii izolirovannoĭ aorty krysy.