Autoantibodies in myotonic dystrophy.
We evaluated some immunological parameters in a group of 24 patients affected with myotonic dystrophy (MD). IgG, IgA, IgM immunoglobulin serum levels resulted decreased in most of the patients. Anti-smooth-muscle antibodies have been found in 10 out of 24 patients (45.5%). Moreover in some of them decreased C3 and C4 complement fraction serum levels have been found. Our data confirm the existence of some immunological abnormalities in a great number of subjects affected with the disease. Besides, these data evidence for most of the subjects the presence of autoantibodies non-organ-specific direct against myocellular antigens. These autoantibodies could be considered the expression of suffering of muscular fibres.
Fiorito
S
S
Instituto di l Clinica Medica dell'Università di Roma La Sapienza.
Pocobelli
D
D
Antonini
G
G
Picelli
A
A
Fragola
P V
PV
Autore
C
C
Magrini
L
L
Cannata
D
D
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000276:immunology*
D001323:Autoantibodies; D007136:Immunoglobulins; D003165:Complement System Proteins