title: [Investigation of the functional properties of domains of alpha-actinin].
abstract: The role of domains in rabbit skeletal muscle alpha-actinin was investigated. The binding center of alpha-actinin containing F-actin is localized in the N-terminal domain, while the C-terminal domain provides for dimerization of the protein molecule. A model of structural organization of the alpha-actinin was proposed, according to which the subunits within the molecule are oriented so that the N-terminal domains localized on the opposite sides of the protein molecule form the binding centers of alpha-actinin with F-actin.
authors.forename: M Sh
authors.initials: MSh
authors.lastname: Simonidze
authors.forename: K Sh
authors.initials: KSh
authors.lastname: Kuridze
authors.forename: N Sh
authors.initials: NSh
authors.lastname: Nadirashvili
authors.forename: M M
authors.initials: MM
authors.lastname: Zaalishvili
mesh_terms: D000185:Actinin / Q000378:metabolism*; D000199:Actins / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D004591:Electrophoresis, Polyacrylamide Gel; D009132:Muscles / Q000378:metabolism; D011817:Rabbits
chemical_list: D000199:Actins; D000185:Actinin
vernacular_title: Issledovanie funktsional'nykh svoĭstv domenov alpha-aktinina.