Uricosuric effect of irtemazole in healthy subjects.
Following a single dose of 50 mg irtemazole per os, plasma uric acid levels decreased after 1 h and fell to 53.5% of the original value within 6-12 h. Renal uric acid excretion increased up to 66 mg/h 30 min after drug application and reached its maximum of 151 mg/h 30 min later. Uric acid clearance also increased after 30 min and reached its maximum of 56 ml/min after 60 min. The response of the kidney to irtemazole is faster than to benzbromarone or probenecid. Lowering of plasma uric acid has a shorter-lasting effect than benzbromarone or probenecid. At 24 h after the application of 50 mg irtemazole the decrease of the plasma uric acid was between 15.4% and 30.0%, or 24.7% on average. Three days after the application the basic plasma uric acid levels were reached again.
Gresser
U
U
Medizinische Poliklinik der Universität München.
Zöllner
N
N
D000284:Administration, Oral; D000328:Adult; D001562:Benzimidazoles / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000097:blood; D008297:Male; D011687:Purines / Q000008:administration & dosage; D014527:Uric Acid / Q000097:blood*; D014528:Uricosuric Agents / Q000494:pharmacology*; D019820:Xanthine; D014970:Xanthines / Q000097:blood
D001562:Benzimidazoles; D007042:Hypoxanthines; D011687:Purines; D014528:Uricosuric Agents; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; C060889:irtemazole