Allogenic stimulus induces prostaglandin and thromboxane production in T lymphocytes.
We have examined the influence of an allogeneic stimulus on T lymphocyte prostanoid synthesis. PGE2 and TXB2 (the stable product of TXA2) were determined by radioimmunoassay. When T cells were derived from alloimmunized animals, the production of PGE2 and TXA2 was significantly higher than that of non-immunized cells. Moreover, T immune lymphocytes in the presence of the immunized alloantigen showed an increment in prostanoid production. We propose that the allogeneic stimulus provides a signal to the T lymphocytes for an increase in prostanoid synthesis.
Genaro
A M
AM
Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN) Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina (CONICET), Buenos Aires.
Cremaschi
G A
GA
Borda
E S
ES
D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D007114:Immunization; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D011453:Prostaglandins / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D013929:Thromboxane B2 / Q000096:biosynthesis; D013931:Thromboxanes / Q000096:biosynthesis*
D011453:Prostaglandins; D013931:Thromboxanes; D013929:Thromboxane B2; D015232:Dinoprostone