title: [Theory of metabolism regulation: a complete system of equations for regulation coefficients].
abstract: Basic quantitative parameters of control in a metabolic system are considered: control coefficients of enzymes with respect to metabolic fluxes and concentrations, and in the case when there are conservation laws, the response coefficients of metabolic fluxes and concentrations to changes in the conserved sums of metabolite concentrations (e. g. conserved moieties). Relationships are obtained which generalize the well known connectivity relations for the case of metabolites binding by conservation laws. Additional relationships are obtained which complement the set of connectivity relations up to the complete system of equations for determining all the control coefficients. The control coefficients are expressed through the enzyme elasticity coefficients, steady state metabolic fluxes and concentrations. Formulas are derived which express response coefficients of flux and concentrations through the enzyme control and elasticity coefficients and metabolite concentrations.
authors.forename: B N
authors.initials: BN
authors.lastname: Kholodenko
authors.forename: L I
authors.initials: LI
authors.lastname: Erlikh
mesh_terms: D004798:Enzymes; D008433:Mathematics; D008660:Metabolism; D008954:Models, Biological
chemical_list: D004798:Enzymes
vernacular_title: Teoriia reguliatsii metabolizma: polnaia sistema uravneniĭ dlia koéffitsientov reguliatsii.