[Hemodynamic effects of zinc sulfate on anesthetized open-chest dogs].
ZnSO4 3-5 mg/kg iv decreased systolic blood pressure, diastolic blood pressure and mean arterial blood pressure, +dP/dtmax, -dP/dtmax, VCE- +dP/dtmax, and left ventricular systolic pressure. However, ZnSO4 had no significant effects on T values and total peripheral resistance. In addition, ZnSO4 obviously decreased heart rate and cardiac index. These results suggest that iv ZnSO4 may cause hypotension via cardiac inhibition.
Ma
F J
FJ
Zhao
G S
GS
Li
X G
XG
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D006168:Guinea Pigs; D006334:Heart Function Tests; D006439:Hemodynamics / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D013431:Sulfates / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology*; D019287:Zinc Sulfate
D013431:Sulfates; D019287:Zinc Sulfate; D015032:Zinc