Effect of chronic intake of ethanol on the binding of vasoactive intestinal peptide to rat spleen lymphoid cells.
1. The effect of chronic intake of ethanol on the binding of vasoactive intestinal peptide (VIP) to rat spleen lymphoid cells was investigated. 2. The intake chronic of ethanol elicited an increase in specific VIP binding. 3. This increase was due to an increase in binding capacity of both the high and the low affinity binding sites. 4. There was a decrease in the affinities of both classes of VIP binding sites.
Jimenez
J
J
Departamento de Bioquimica Médica y Biología Molecular, Facultad de Medicina, Adva, Sánchez, Pizjuán, Sevilla, Spain.
Goberna
R
R
Mesa
J C
JC
Morales
M F
MF
Calvo
J R
JR
D000437:Alcoholism / Q000378:metabolism; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007700:Kinetics; D008221:Lymphoid Tissue / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D007457:Iodine Radioisotopes; D014660:Vasoactive Intestinal Peptide; D000431:Ethanol