[The effect of Krebs cycle intermediates on the size of the necrotic zone and on the course of early postocclusion arrhythmia in experimental myocardial infarct in rats].
The differential indicator method of determining the zone of myocardial ischemia and necrosis was used to show that sodium succinate and malate (100 and 200 mg/kg) significantly decrease the size of the necrotic zone in the acute period of myocardial infarction and alleviate the course of early postocclusion arrhythmias. The dose-dependent cardioprotective effect of sodium malate was noted.
Sernov
L N
LN
Snegireva
G V
GV
Gatsura
V V
VV
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D002952:Citric Acid Cycle; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008297:Male; D008298:Maleates / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D051381:Rats; D013386:Succinates / Q000627:therapeutic use*; D019802:Succinic Acid; D013997:Time Factors
D008298:Maleates; D013386:Succinates; C030272:maleic acid; D019802:Succinic Acid
Vliianie intermediatov tsikla Krebsa na razmery zony nekroza i techenie rannikh postokkliuzionnykh aritmiĭ pri éksperimental'nom infarkte miokarda u krys.