title: [Metabolism of ornithine in human gingival tissue].
abstract: The behavior of two enzymes of the ornithine pathway, leading to the formation of proline and, eventually, of collagen, arginase and ornithine oxo-acid aminotransferase has been investigated in normal and inflamed gingival tissue. Both enzymatic activities show a statistically significant decrease in pathological samples as compared to normal ones. The data on arginase activity may be in agreement with the already documented low level of urea in pathological gingival fluid, while a decrease of the ornithine aminotransferase activity could be linked to the phenomenon of gingival retraction, i.e. the lack of complete regeneration of gingival tissue usually observed in chronically inflamed subjects, that would be reasonably parallel to a decreased proline/collagen synthesis.
authors.forename: G G
authors.initials: GG
authors.lastname: Pinna
authors.forename: G
authors.initials: G
authors.lastname: Chessa
authors.forename: P F
authors.initials: PF
authors.lastname: Luglié
authors.forename: R
authors.initials: R
authors.lastname: Trova
authors.forename: A
authors.initials: A
authors.lastname: Sisini
mesh_terms: D001119:Arginase / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis*; D005881:Gingiva / Q000201:enzymology / Q000378:metabolism*; D005891:Gingivitis / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D009953:Ornithine-Oxo-Acid Transaminase / Q000378:metabolism*; D011392:Proline / Q000096:biosynthesis*; D000637:Transaminases / Q000378:metabolism*
chemical_list: D003094:Collagen; D011392:Proline; D000637:Transaminases; D009953:Ornithine-Oxo-Acid Transaminase; D001119:Arginase
vernacular_title: Metabolismo dell'ornitina in tessuto gengivale umano.