Localization of interleukin 6 mRNA in human tonsils by in situ hybridization.
We have investigated which areas produce interleukin 6 (IL 6) in human tonsils. This growth factor is required for the terminal differentiation of B lymphocytes into plasmocytes. Using 35S-labeled IL 6 cDNA we demonstrated IL 6 gene expression over various areas of the tonsils, with consistent exception of the follicles, by in situ hybridization. It is, therefore, proposed that B cells are stimulated during their migration out of the follicles.
Bosseloir
A
A
Institute of Histology, University of Liège, Belgium.
Hooghe-Peters
E L
EL
Heinen
E
E
Cormann
N
N
Kinet-Denoël
C
C
Vanhaelst
L
L
Simar
L
L
D001402:B-Lymphocytes / Q000502:physiology*; D015342:DNA Probes; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D014066:Palatine Tonsil / Q000166:cytology / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics
D015342:DNA Probes; D015850:Interleukin-6; D012333:RNA, Messenger