[Analysis of blood vessel invasion by cells of thyroid follicular carcinoma using image processing combined with immunohistochemistry].
By means of image processing combined with immunohistochemistry, we determined the nuclear morphometric parameters, DNA content and thyroglobulin content in angio-invasive cell and noninvasive cell groups in 5 cases of thyroid follicular carcinoma. The results showed that the two cell groups are quite different from each other. Morphologically, angio-invasive cells showed smaller nuclear size and irregular nuclear shape. DNA content in invasive cells was far more than in noninvasive cells. In addition, invasive cells contain more thyroglobulin than non-invasive cells.
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D000230:Adenocarcinoma / Q000032:analysis / Q000473:pathology*; D002466:Cell Nucleolus / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness; D013954:Thyroglobulin / Q000032:analysis; D013964:Thyroid Neoplasms / Q000032:analysis / Q000473:pathology*
D004273:DNA, Neoplasm; D013954:Thyroglobulin