title: Sequential combination of methotrexate and 1-beta-D-arabinofuranosylcytosine shows synergistic effect on the generation of DNA strand breaks in a human promyelocytic leukemia cell line.
authors.affiliation: Department of Pediatrics, Kyoto University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Tanizawa
authors.forename: M
authors.initials: M
authors.lastname: Kubota
authors.forename: T
authors.initials: T
authors.lastname: Takimoto
authors.forename: T
authors.initials: T
authors.lastname: Kito
authors.forename: Y
authors.initials: Y
authors.lastname: Akiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Kiriyama
authors.forename: H
authors.initials: H
authors.lastname: Mikawa
mesh_terms: D001085:Arabinofuranosylcytosine Triphosphate / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology; D003561:Cytarabine / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D004249:DNA Damage; D004273:DNA, Neoplasm / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004357:Drug Synergism; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000494:pharmacology; D002955:Leucovorin / Q000494:pharmacology; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D008727:Methotrexate / Q000008:administration & dosage / Q000494:pharmacology*; D013936:Thymidine / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D004273:DNA, Neoplasm; D007042:Hypoxanthines; D003561:Cytarabine; D001085:Arabinofuranosylcytosine Triphosphate; D019271:Hypoxanthine; D003513:Cycloheximide; D002955:Leucovorin; D013936:Thymidine; D008727:Methotrexate