[Probenecid affects liver metabolism].
The effect of probenecid on the pharmacokinetics of phenprocoumon (PPC) given as a single oral or intravenous dose, on the vitamin-K-dependent protein-C-antigen, and on the pharmacokinetics of antipyrine and 6 beta-hydroxycortisol was determined in 14 healthy volunteers. Probenecid caused a 75% decrease in urinary excretion of PPC and PPC-glucuronide and shortened the plasma half-life of PPC significantly (by about 35%). The results after oral and intravenous administration of PPC did not differ significantly. Plasma protein-C-antigen concentrations following intravenous PPC were significantly increased by probenecid. The plasma half-life of antipyrine after 7 days of probenecid therapy was significantly diminished. Accordingly, urinary excretion of 6 beta-hydroxycortisol was significantly increased. These data appear for the first time to reveal enzyme-inducing properties of probenecid, which may be responsible for the shortening of PPC plasma half-life when probenecid is given simultaneously. In addition, the influence of probenecid on plasma protein-C-antigen concentrations may indicate further effects of probenecid on liver metabolism.
Bammel
A
A
I. Medizinische Klinik, Christian-Albrechts-Universität, Kiel.
Mönig
H
H
Zurborn
K H
KH
Ohnhaus
E E
EE
Kirch
W
W
D015110:4-Hydroxycoumarins / Q000493:pharmacokinetics*; D000328:Adult; D000941:Antigens; D000983:Antipyrine / Q000493:pharmacokinetics; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism*; D010644:Phenprocoumon / Q000493:pharmacokinetics*; D011339:Probenecid / Q000494:pharmacology*; D011486:Protein C / Q000276:immunology
D015110:4-Hydroxycoumarins; D000941:Antigens; D011486:Protein C; C001380:6 beta-hydroxycortisol; D011339:Probenecid; D010644:Phenprocoumon; D000983:Antipyrine; D006854:Hydrocortisone
Probenecid beeinflusst den Lebermetabolismus.