title: Vasoactive intestinal peptide: behavioral effects in the rat and hamster.
abstract: The behavioral effects of intracerebroventricular (ICV) injection of the brain-gut peptide vasoactive intestinal peptide (VIP) were quantified with a behavioral sampling technique in home-caged, nondeprived, male and female albino rats and golden hamsters. ICV VIP sex-dependently decreased observed resting behavior during 1 hr after injections in both rats and hamsters at 0.1-10.0 micrograms. Grooming behavior was increased in hamsters, and rearing and standing behaviors were increased in rats, sex-dependently at VIP doses that decreased resting. Drinking behavior was suppressed in rats by VIP at 10.0 micrograms. Intraperitoneal (IP) VIP (100.0 micrograms/kg) increased 5% ethanol intake and decreased eating behavior in fluid-deprived male rats. The increase in ethanol intake produced by IP VIP was prevented by IP cholecystokinin octapeptide (CCK, 4.0 micrograms/kg). VIP potently controls resting and ingestive behaviors, suggesting a role for this neuropeptide, along with CCK, in the feedback regulation of rodent behavior.
authors.affiliation: Department of Psychology, University of Southern Colorado, Pueblo 81001-4901.
authors.forename: P J
authors.initials: PJ
authors.lastname: Kulkosky
authors.forename: J S
authors.initials: JS
authors.lastname: Doyle
authors.forename: V I
authors.initials: VI
authors.lastname: Cook
authors.forename: G W
authors.initials: GW
authors.lastname: Glazner
authors.forename: M A
authors.initials: MA
authors.lastname: Foderaro
mesh_terms: D000428:Alcohol Drinking; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002766:Cholecystokinin / Q000494:pharmacology; D006224:Cricetinae; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D008297:Male; D051381:Rats; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
chemical_list: D014660:Vasoactive Intestinal Peptide; D000431:Ethanol; D002766:Cholecystokinin