title: Circulating immune complexes in sickle cell anaemia.
abstract: A polyethylene-glycol insoluble serum fraction was studied in patients with sickle cell anaemia during the steady state of the disease. The levels of C1q-precipitins were normal but increased amounts of proteins, IgM C3 and factor B were detected in this immune complex enriched serum fraction. These findings are a sign that circulating immune complexes can be detected even in the asymptomatic period of the disease.
authors.affiliation: Department of Clinical Medicine, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: E A
authors.initials: EA
authors.lastname: Donadi
authors.forename: I F
authors.initials: IF
authors.lastname: Carvalho
authors.forename: R P
authors.initials: RP
authors.lastname: Falcão
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis; D002648:Child; D015922:Complement C1q / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D011234:Precipitins / Q000032:analysis
chemical_list: D000936:Antigen-Antibody Complex; D001798:Blood Proteins; D007136:Immunoglobulins; D011234:Precipitins; D015922:Complement C1q