[The effect of splenic factors on the course of the autoimmune process in New Zealand mice].
To exert an effect on the autoimmune process in 54 New Zealand mice aged 6 and 10 months, 0.2 ml of a solution obtained in perfusion of isolated pig's spleen (perfusate) was injected intravenously at intervals of 2--3 days (a total of 8 injections). The control group (43 mice) received injections of an isotonic buffer solution in the same regimen. After the end of perfusate administration the number of antibodies to DNA and the level of circulating immune complexes (IC) reduced markedly in the blood of the experimental mice as compared to these values in the control group. Kidney immunofluorescence demonstrated reduced number of IC deposits in the glomeruli of 6- and 10-month old mice of the experimental group. The perfusate contributes, probably, to intensified excretion of IC from the blood flow and kidneys of the experimental mice.
Tsypin
A B
AB
Nasonova
V A
VA
Vedernikova
L A
LA
Pleskovskaia
G N
GN
Beletskaia
L V
LV
D000375:Aging / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D015551:Autoimmunity / Q000276:immunology*; D004247:DNA / Q000276:immunology; D007668:Kidney / Q000276:immunology; D051379:Mice; D008814:Mice, Inbred NZB / Q000276:immunology*; D010477:Perfusion / Q000379:methods; D013154:Spleen / Q000276:immunology*; D013552:Swine
D000906:Antibodies; D000936:Antigen-Antibody Complex; D004247:DNA
Vliianie selezenochnykh faktorov na techenie autoimmunnogo protsessa u novozelandskikh mysheĭ.