[Preliminary study of mechanism of HFMC inhibiting sperm functions].
In this study, the mechanism of HFMC (copolymer of hydroxyethyl methacrylate-methacrylic acid-ethyl methacrylate) inhibiting sperm functions was investigated in vitro. We found that HFMC could decrease the pH value of sperm suspension with an increase in HFMC concentration to a certain extent but the maximum decrease is no more than a value of 2.5. The inhibitory effects of HFMC on the sperm functions could be partly inverted after the pH values of sperm suspension had been shifted to its original level of pH 7.4 by the addition of proper amounts of basic solution. It is suggested that the descent of pH value may be one of the causes of HFMC inhibiting sperm functions.
Wen
J P
JP
Luo
Z Q
ZQ
Xu
R P
RP
D000179:Acrylates / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008297:Male; D008689:Methacrylates / Q000494:pharmacology*; D011109:Polymethacrylic Acids / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects*; D013084:Sperm-Ovum Interactions / Q000187:drug effects; D013089:Spermatocidal Agents
D000179:Acrylates; D008689:Methacrylates; D011109:Polymethacrylic Acids; D013089:Spermatocidal Agents; C063229:hydroxyethyl methacrylate-methacrylic acid-ethyl methacrylate copolymer