[Studies on the controlled-release pellets of nifedipine].
Controlled-release pellets of nifedipine have been prepared and evaluated by in vitro and in vivo (in dogs and human bodies) tests in the study. The pellet-released drug fitted to a first-order process (K = 0.23 h-1) as wall as Higuchi's function (K = 37.05 h-1/2). After administration the concentration of these pellets was more steady than that of sustained-release pellets reported in dogs. It was also found to be steady in human. The concentration reached 20 ng/ml in about 10 minutes and stayed between 20-70 ng/ml within from 10 minutes to 15 hours. The bioavailability of the controlled-release pellets is a little higher than that of the conventional pellets. The pharmacokinetic character of nifedipine has primarily been explored in this article, and corresponds with a two-compartment model (t1/2 beta = 3.5 h).
Yang
T H
TH
Zhang
J S
JS
Liu
G J
GJ
Chen
G
G
D000328:Adult; D000818:Animals; D001682:Biological Availability; D003692:Delayed-Action Preparations; D004285:Dogs; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D009543:Nifedipine