[Cloning and structural analysis of genes coding for tumor necrosis factor and lymphotoxin in rabbits].
Genes, coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta), have been cloned from the rabbit genomic library. The two genes are tandemly arranged and separated only by 1 kb of DNA as previously observed in human and mouse genomes. We have sequenced the entire rabbit lymphotoxin gene (LT) and calculated the amino acid sequence of the rabbit LT whose cDNA is not yet cloned. We also analyzed the upstream sequences of this gene and revealed a number of recognition sites for the known transcriptional factors. The rabbit TNF gene comprised in the cloned genomic region has been sequenced earlier.
Shakhov
A N
AN
Kuprash
D V
DV
Turetskaia
R L
RL
Azizov
M M
MM
Andreeva
A V
AV
Nedospasov
S A
SA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D008040:Genetic Linkage; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008969:Molecular Sequence Data; D011817:Rabbits; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha; D004247:DNA
Klonirovanie i strukturnyĭ analiz genov, kodiruiushchikh faktor nekroza opukholeĭ i limfotoksin krolika.