title: [Studies on antifertility constituents of Siegesbeckia glabrescens Mak].
abstract: Three diterpenes including a new compound were isolated from the whole plant of Siegesbeckia glabrescens Mak. The new one was named as neodarutoside and its structure was elucidated as ent-3 alpha, 15,16-trihydroxy pimarane 3,15-bis-(beta-glucopyranoside) based on the spectral evidence and chemical transformation. The other two were darutigenol and darutoside. Darutoside possesses the activity of termination of early pregnancy in experimental rats at a dosage of 20-40 mg/kg.
authors.forename: X Y
authors.initials: XY
authors.lastname: Dong
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: W
authors.initials: W
authors.lastname: Jin
authors.forename: D X
authors.initials: DX
authors.lastname: Huang
authors.forename: S M
authors.initials: SM
authors.lastname: Shen
authors.forename: H T
authors.initials: HT
authors.lastname: Li
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal; D000818:Animals; D004224:Diterpenes / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D005260:Female; D051381:Rats
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C062911:neodarutoside; C062909:darutoside; C062910:darutigenol