The hepatic lipid peroxidation, copper and fibrosis in cholestatic rats.
Hepatic lipid peroxidation was shown to be stimulated in the livers of cholestatic rats with increased hydroxyproline levels. In another group, cholestatic rats were fed with a copper-supplemented diet to increase hepatic copper levels. Although liver copper concentrations increased about 16-fold in copper supplemented cholestatic rats compared to normally fed cholestatic rats, no change was observed either in hepatic lipid peroxidation or in hydroxyproline levels.
Aykac
G
G
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
Ozdemirler
G
G
Alptekin
N
N
Arican
N
N
Oz
B
B
Uysal
M
M
Oz
H
H
D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D002780:Cholestasis, Intrahepatic / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D003300:Copper / Q000378:metabolism*; D004032:Diet; D004195:Disease Models, Animal; D006909:Hydroxyproline / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D008099:Liver / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000209:etiology* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001647:Bile Acids and Salts; D003300:Copper; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin; D006909:Hydroxyproline