Enhanced formation of lipid peroxides might contribute to the high sensitivity of spontaneously hypertensive rats towards isoproterenol-induced myocardial damage.
Lipid peroxidation as well as enzyme and isoenzyme activities in heart and blood plasma were investigated in 8- and 20-week-old SHR after administration of 40 mg/kg body weight isoproterenol in comparison to WKY rats in order to examine the susceptibility of the hearts of hypertensive animals towards catecholamine-induced damage. The mortality of SHR after isoproterenol application was distinctly higher as compared with WKY rats. SHR showed significantly higher concentrations of lipid peroxides in the myocardium after isoproterenol. Distinctly higher plasma activities of CK, isoenzymes of LDH and ASAT as well as markedly lower CK activities in the myocardium point to an enhanced sensitivity of SHR to catecholamine-induced damage. The results obtained in this study favour the suggestion that an exaggerated nonenzymatic and perhaps enzymatic formation of peroxidized lipids in the myocardium might contribute to this increased sensitivity.
Papies
B
B
Department of Pathological and Clinical Biochemistry, Humboldt University, Berlin, GDR.
Schimke
I
I
Moritz
V
V
D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001835:Body Weight; D009202:Cardiomyopathies / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism*; D003327:Coronary Disease / Q000378:metabolism; D003402:Creatine Kinase / Q000378:metabolism; D005609:Free Radicals; D006973:Hypertension / Q000503:physiopathology*; D007527:Isoenzymes / Q000378:metabolism; D007545:Isoproterenol; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D009929:Organ Size; D010101:Oxygen Consumption; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013858:Thiobarbiturates
D005609:Free Radicals; D007527:Isoenzymes; D008054:Lipid Peroxides; D013858:Thiobarbiturates; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D007545:Isoproterenol