Single dose pharmacokinetics of calcium antagonist nifedipine in ethanol dependent rats.
The single dose (6 mg/kg, iv) kinetic study of calcium antagonist nifedipine was performed in plasma and brain tissue of control rat and after single and prolonged treatment with ethanol. The prolonged administration of ethanol for 6 weeks lowered the plasma concentration of nifedipine and decreased its penetration into the brain tissue. The opposite effects were shown in rats treated with ethanol for 6 months.
Siembab
D
D
Department of Experimental and Clinical Pharmacology, Medical Academy, Warszawa, Poland.
Janicki
P K
PK
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D009543:Nifedipine / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains
D009543:Nifedipine