Interleukin-1 and interleukin-1 inhibitor production by human adherent cells stimulated with periodontopathic bacteria.
This study examined the effect of the putative periodontopathic bacteria Bacteroides gingivalis and Fusobacterium nucleatum on the production of interleukin-1 (IL-1) and IL-1 inhibitors by human plastic-adherent mononuclear cells from normal donors. Fusobacterium mortiferum was used as a non-oral, non-pathogenic control organism. Unstimulated adherent cells spontaneously secreted an IL-1 inhibitor, whereas stimulation with B. gingivalis induced the synthesis and secretion of IL-1. With both fusobacteria IL-1 was present in the intracellular environment, whereas the predominant secretory product was either IL-1 or an IL-1 inhibitor. These results suggest that bacteria are capable of modulating cytokine production by monocytes and may thereby alter the local immune response.
Walsh
L J
LJ
Department of Social & Preventive Dentistry, University of Queensland Dental School, Brisbane, Australia.
Stritzel
F
F
Yamazaki
K
K
Bird
P S
PS
Gemmell
E
E
Seymour
G J
GJ
D000328:Adult; D001439:Bacteroides / Q000276:immunology*; D002448:Cell Adhesion; D002478:Cells, Cultured; D005260:Female; D005673:Fusobacterium / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008222:Lymphokines / Q000096:biosynthesis*; D008297:Male; D010510:Periodontal Diseases / Q000382:microbiology*
D007375:Interleukin-1; D008222:Lymphokines