title: Platelet intracellular pH in essential hypertensives and normotensives.
abstract: Using the intracellularly trapped pH-sensitive fluorescent dye, BCECF, basal intracellular pH was measured in 18 essential hypertensives and 23 normotensives. The average intracellular pH was slightly, but not significantly, lower in the hypertensives (7.173 +/- 0.017 versus 7.211 +/- 0.014, P = 0.09). Although basal intracellular pH is not significantly altered in hypertension, abnormal regulation of intracellular pH during growth factor or agonist stimulation may play a role in the development or maintenance of hypertension.
authors.affiliation: Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0500.
authors.forename: A B
authors.initials: AB
authors.lastname: Weder
authors.forename: S E
authors.initials: SE
authors.lastname: Bahadosingh
authors.forename: G R
authors.initials: GR
authors.lastname: Neagos
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D005260:Female; D005452:Fluoresceins; D005456:Fluorescent Dyes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000097:blood*; D008297:Male; D008722:Methods
chemical_list: D005452:Fluoresceins; D005456:Fluorescent Dyes; C043829:2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein