Novel secoiridoid lactones from Jasminum multiflorum.
Four new secoiridoid lactones, jasmolactones A [1], B [2], C [3], and D [4], were isolated from the aerial part of Jasminum multiflorum. The structures of these compounds, which contain a novel bicyclic 2-oxo-oxepano[4,5-c]pyran ring system, were established by spectral analyses and chemical correlations. Pharmacological testing revealed that jasmolactones B and D possess coronary vasodilating and cardiotropic activities.
Shen
Y C
YC
School of Pharmacy, National Taiwan University, Taipei, Republic of China.
Chen
C H
CH
D000818:Animals; D002316:Cardiotonic Agents / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007495:Iridium; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014665:Vasodilator Agents / Q000302:isolation & purification*
D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal; D007783:Lactones; D014665:Vasodilator Agents; D007495:Iridium