[Activity of platelet serotonin receptors of patients with endogenous depression before and after treatment with antidepressive agents].
Effective 5-HT concentration eliciting the half-maximal rate of platelet deformation (aggregation) in drug-free bipolar or unipolar depressed women was significantly (p less than 0.001) lower as compared with matched controls (0.13 +/- 0.04 microM and 0.532 +/- 0.1 microM, respectively). After 1-3 months of antidepressant treatment this value increased to 0.47 +/- 0.16 microM and was no longer different from control. Possible mechanisms controlling the activity of serotonin2 platelet receptors are discussed.
Katasonov
A B
AB
Beliaev
B S
BS
Brusov
O S
OS
Zlobina
G P
GP
Faktor
M I
MI
D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001792:Blood Platelets / Q000032:analysis*; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010974:Platelet Aggregation; D011985:Receptors, Serotonin / Q000032:analysis* / Q000502:physiology; D012701:Serotonin / Q000097:blood*; D013997:Time Factors
D000928:Antidepressive Agents; D011985:Receptors, Serotonin; D012701:Serotonin
Aktivnost' serotoninovykh retseptorov na trombotsitakh bol'nykh éndogennymi depressiami do i posle lecheniia antidepressantami.