Effect of ciclosporin on rat liver and kidney glutathione content.
The effect of ciclosporin (CS) on hepatic and renal glutathione was investigated in 36 male Sprague-Dawley rats weighing 200-250 g each. CS (120 micrograms/kg/day, i.p.) treatment caused a significant decrease in both hepatic and renal glutathione content. The rat hepatic glutathione levels decreased by 16% within 1 h of a single CS treatment and continued decreasing to 50% following chronic treatment with CS for 7 days. Renal glutathione content decreased only marginally (3%) within 1 h of CS treatment. However, it decreased by 17% within 24 h and continued to decrease during the 7 days of chronic treatment. This decrease in the content of both hepatic and renal glutathione may contribute to the toxicity observed during treatment with CS.
Duruibe
V A
VA
Clinical Pharmacology Research Unit, College of Pharmacy, Florida Agricultural and Mechanical University, Miami.
Okonmah
A
A
Blyden
G T
GT
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003524:Cyclosporins; D005978:Glutathione