[Quantitative changes in mitochondrial membrane structure of leukemic cells in children with acute leukemia].
The quantitative changes of mitochondrial membrane of AL cells were studied by morphometric technique under electron microscope. We found that the delta sM was 25.0% more increased and the delta mM was 18.0% more decreased in AL than in the controls. The extent of changed of delta mM in C-ALL and N-ALL was much greater than that in T-ALL. We also found that the changing extent of delta mM in AL is related with long term disease-free survival. During the period of inductive therapy, observation on the dynamic changes of delta mM may provide a useful information for predicting the therapeutic effects and the therapeutic scheme individually.
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D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*; D011379:Prognosis