[The effect of phalloidin and its nontoxic derivative dethiophalloidin on morphological transformation of mitochondria].
As the in vitro experiments showed, the process of osmotic swelling of isolated liver mitochondria was inhibited by phalloidine produced by mushrooms Amanita phalloides. The degree of the effect pronounced depended both on the heptapeptide concentration and duration of the action on mitochondria. Mitochondrial contraction caused by ATP adding was also inhibited. The control experiments performed using dethiophalloidine as a nontoxic derivate showed the absence of similar effect. The data obtained point to functional significance of the actin-like protein as a factor capable of forming a continuous primembrane system connected with the integral components and controlling the volume of mitochondria themselves.
Stozharov
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D000818:Animals; D003864:Depression, Chemical; D066298:In Vitro Techniques; D008928:Mitochondria / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000648:ultrastructure; D008933:Mitochondrial Swelling / Q000187:drug effects*; D009842:Oligopeptides / Q000494:pharmacology*; D010590:Phalloidine / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats
D009842:Oligopeptides; D010590:Phalloidine; C063636:dethiophalloidin
Issledovanie vliianiia falloidina i ego netoksichnogo proizvodnogo detiofalloidina na protsessy morfologicheskoĭ transformatsii mitokhondriĭ.