title: Effects of chlorhexidine solution on neutrophil locomotion in vitro.
abstract: The aim of this study was to ascertain the effect of low concentrations of chlorhexidine on the locomotor behaviour of neutrophils. A special feature was the use of a direct test of chemotaxis. Neutrophils recovered from peripheral blood of healthy adult volunteers were tested for chemokinesis and chemotaxis in the presence of chlorhexidine. A moderate dose-related direct response was observed in respect of both these parameters. It was also apparent that increasing concentrations of the drug inhibited a greater proportion of cells, so that there was total immobility at 0.2 per cent and many cells appeared lysed.
authors.forename: T L
authors.initials: TL
authors.lastname: Watts
authors.forename: I
authors.initials: I
authors.lastname: Addison
authors.forename: B
authors.initials: B
authors.lastname: Johnson
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002465:Cell Movement / Q000187:drug effects*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D002710:Chlorhexidine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects*
chemical_list: D002710:Chlorhexidine