title: [The diagnostic value of CT in siderophilia (primary idiopathic hemochromatosis)].
abstract: CT, due to its high resolution of density, is suitable, within certain limits, to quantify iron contents in the liver. - Diagnostic value and limits of dual-energy-computed tomography after 38 examinations, 31 of them in patients with verified haemochromatosis, are described: In a progressive state of iron overload a high correlation exists between results of computed tomography and usual reference methods of iron metabolism (iron determination by absorption spectrometry and histologic examination, serum-iron-level, serum-ferritin-level, relative transferrin saturation, desferal test). - With a specificity of nearly 100% CT shows a minor or medium iron overload only with low sensitivity. - Because of its noninvasive nature CT is an alternative method of biopsy in progressive liver disease with suspected hepatic siderosis.
authors.affiliation: Klinik für Radiologie, Karl-Marx-Universität Leipzig.
authors.forename: R
authors.initials: R
authors.lastname: Klöppel
authors.forename: M
authors.initials: M
authors.lastname: Reinhardt
authors.forename: S
authors.initials: S
authors.lastname: Lieberenz
authors.forename: M
authors.initials: M
authors.lastname: Fuchs
authors.forename: K
authors.initials: K
authors.lastname: Winnefeld
authors.forename: G
authors.initials: G
authors.lastname: Machnik
mesh_terms: D005234:Fatty Liver / Q000000981:diagnostic imaging; D006432:Hemochromatosis / Q000000981:diagnostic imaging*; D006801:Humans; D007501:Iron / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D007501:Iron
vernacular_title: Untersuchungen zur diagnostischen Wertigkeit der CT bei der Siderophilie (primäre idiopathische Hämochromatose).