[The effect of vitaton on a model of isoprenaline myocardiopathy in rats].
The influence of the combined preparation vitaton (Pharmachim) was studied on some functional, biochemical and morphological changes, induced after four-fold subcutaneous administration of 100 mg/kg of isoprenaline. The experiments were carried out on three groups: control nontreated, control treated with isoprenaline and experimental, treated simultaneously with isoprenaline and 500 mg/kg of vitalon, administered orally. The preparation was used 3 days before and 2 days after the administration of isoprenaline. Evaluation of the preparation action was made by the following parameters: ECG in the II standard lead, effect on serum level of cholesterol, triglycerols, cholesterol and lipoproteins with high, low and very low density, enzymic activity of hydroxybutiroldehydrogenase (HBDH), creatinephosphokinase (CPK), aspartataminotransferase (ASAT) and alaninaminotransferase (ALAT). Pathomorphological and morphometric studies of the hearts were performed as well. The results from the conducted experiments showed that vitaton reduced pathological changes in the electrocardiographic recordings as well as the abnormal increase in cholesterol and fractions of lipoproteins with low density. Beside this it lowered considerably the enzymic activity, observed under the influence of isoprenaline. The preparation diminished the area of myocardial damage more than twice, estimated by the index of the myocardial damage. The effect of vitalon on the model of isoprenaline myocardiopathy could be explained by its metabolic action and more exactly by its influence on protein synthesis and on lipid metabolism.
Gendzhev
Z
Z
Taskov
M
M
Petrova
V
V
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D004562:Electrocardiography; D006321:Heart / Q000503:physiopathology; D007545:Isoproterenol / Q000633:toxicity*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014815:Vitamins / Q000627:therapeutic use*
D014815:Vitamins; D007545:Isoproterenol
Vliianie na preparata vitaton vŭrkhu model na izoprenalinova miokardiopatiia na plŭkhove.