[Plasma concentrations of 2% lidocaine during epidural analgesia in urology].
The plasma levels of 2 per cent lidocain solution, administered in a mean dose 291.6 mg for epidural analgesia in 24 urologic patients, subjected to transurethral resection. Peak lidocain concentration occurred on the 20 minute and was 2.73 +/- 1.25 mg/l. Positive correlation was found between the administered analgetic dose and the plasma concentration and inverse correlation between age and injected dose. The plasma concentration fall during the studied intervals showed positive correlation with the injected dose and the plasma level being reached; there was inverse correlation between patients age and the fall in plasma lidocain levels. Plasma lidocain levels were for the first time estimated by use of highly effective fluid chromatography--HPLC.
Bovianska
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000187:drug effects; D015360:Analgesia, Epidural; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012996:Solutions; D013997:Time Factors; D014570:Urologic Diseases / Q000097:blood* / Q000601:surgery
D012996:Solutions; D008012:Lidocaine
Prouchvane na plazmenite kontsentratsii na lidokain 2% pri epiduralna analgeziia v urologiiata.