Methylscopolamine and conditioned location avoidance.
On alternate days, rats were confined to one side of a shuttlebox following IP administration of saline and to the other following the peripherally-acting muscarinic antagonist, methylscopolamine (1.2 mg/kg). They later avoided the side associated with the drug effect. By duplicating an earlier finding with centrally- and peripherally-acting scopolamine, this result identified aversive peripheral actions of the two drugs as mainly responsible for the effects observed.
Hughes
R N
RN
Department of Psychology, University of Canterbury, Christchurch, New Zealand.
Blampied
N M
NM
Anderson
G J
GJ
Woollett
G J
GJ
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003214:Conditioning, Classical; D005106:Exploratory Behavior / Q000187:drug effects*; D005260:Female; D008297:Male; D018727:Muscarinic Antagonists; D019832:N-Methylscopolamine; D051381:Rats; D012602:Scopolamine Derivatives / Q000494:pharmacology*
D018727:Muscarinic Antagonists; D012602:Scopolamine Derivatives; D019832:N-Methylscopolamine