Lack of correlation between the sulfobromophthalein test and fatty liver in diabetic dogs.
The present study was performed to evaluate the correlation between fatty liver and liver function in diabetic dogs. Experimental diabetes was induced in 14 dogs by total pancreatectomy or by alloxan administration, and partial (30%) hepatectomy was performed. Diabetic dogs were compared with control dogs (N = 7) subjected only to partial hepatectomy (30%). Control and diabetic dogs were submitted to the sulfobromophthalein (BSP) liver function test. Serum BSP retention was increased in diabetic dogs but there was no correlation with the extent of fatty infiltration of the liver.
Castro-e-Silva Júnior
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O
Departamento de Cirurgia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
Santos
J E
JE
Augusto
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C
Ceneviva
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D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005234:Fatty Liver / Q000503:physiopathology*; D005260:Female; D006498:Hepatectomy; D008099:Liver / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D013448:Sulfobromophthalein
D005230:Fatty Acids, Nonesterified; D013448:Sulfobromophthalein