Quinolizidine derivatives as potential antitumoral agents.
The activity against lymphocytic leukemia P 388 has been evaluated for thirteen compounds bearing a quinolizidine moiety bound respectively to a phenothiazine nucleus or other isosteric tricyclic systems (12-17), as well to a quinoxalinone (18-20) or an indole (21-24) nucleus. All tested compounds resulted inactive.
Sparatore
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Istituto di Chimica Biologica, Università di Genova.
Boido Canu
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Boido
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Sparatore
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D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D011807:Quinolizines / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D011807:Quinolizines