[Stimulating effect of gamma-aminobutyric acid on rat hippocampal neurons in vitro].
Effects of GABA on the background and electrically stimulated activity of single neurons and population spikes were investigated in isolated hippocampal slices. Application of relatively large GABA concentrations (10(-3) mol/l and more) depressed an antidromic population spike, field EPSP and neuronal background activity. Low concentrations of GABA (less than 10(-3) mol/l) added to the bath increased the population spikes amplitude and the late component of field EPSP, facilitated single neurone responses, their background activity and epileptiform discharges. GABA-evoked depolarization was observed in the majority of the studied neurons. The duality of the GABA action on central neurons are discussed.
Artemenko
D P
DP
Gerasimov
V D
VD
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000166:cytology* / Q000187:drug effects; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013268:Stimulation, Chemical; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid
Vozbuzhdaiushchee deĭstvie gamma-aminomaslianoĭ kisloty na neĭrony gippokampa krysy in vitro.