title: A reticulo-frontal disconnection syndrome.
abstract: Persistent executive deficit, usually seen following prefrontal damage, is reported in a patient recovering from head trauma. Repeated neuroradidological examinations failed to reveal a lesion within the frontal lobes, but a circumscribed lesion in the ventral mesencephalic tegmentum was found. It is proposed that the observed syndrome was caused by damage to mesencephalic reticular nuclei and their projections into prefrontal cortex. The concept of a "reticulo-frontal disconnection syndrome" is introduced and its possible role in head trauma and schizophrenia discussed.
authors.affiliation: Medical College of Pennsylvania/Eastern Pennsylvania Psychiatric Institute, Philadelphia.
authors.forename: E
authors.initials: E
authors.lastname: Goldberg
authors.forename: R M
authors.initials: RM
authors.lastname: Bilder
authors.forename: J E
authors.initials: JE
authors.lastname: Hughes
authors.forename: S P
authors.initials: SP
authors.lastname: Antin
authors.forename: S
authors.initials: S
authors.lastname: Mattis
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000503:physiopathology; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D007802:Language; D008297:Male; D009043:Motor Activity; D009434:Neural Pathways / Q000503:physiopathology; D012154:Reticular Formation / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed