Magnetic resonance microscopy of chemically-induced liver foci.
Magnetic resonance imaging (MRI) is a new imaging technique used in clinical diagnosis. This paper describes extension of the technique to basic research applications--specifically detecting and characterizing chemically-induced liver neoplasms and foci of cellular alteration. Two systems have been built that allow spatial microscopic resolution--more than 100,000 x greater than that of earlier efforts. Use of spin-lattice (T1) and spin-spin (T2) relaxation times permits detailed characterization of the tissue.
Johnson
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GA
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710.
Maronpot
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RR
D000818:Animals; D015197:Carcinogenicity Tests; D004032:Diet; D005260:Female; D008099:Liver / Q000473:pathology* / Q000648:ultrastructure; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D051381:Rats; D011916:Rats, Inbred F344