Effects of 2,3-dibenzylbutane-1,4-diol on vascular smooth muscle of rabbit aorta.
We investigated the effects of 2,3-dibenzylbutane-1,4-diol (DBB), a mammalian lignan derived from human urine, on the contractile response and the 45Ca2+ uptake in the vascular smooth muscle of rabbit aorta. In resting state, DBB did not influence the tension and the 45Ca2+ uptake. DBB inhibited the high KCl- and the CaCl2-induced contraction in the partially depolarized muscle strip. DBB inhibited the noradrenaline- and the angiotensin II-induced contraction, but not the transient contraction evoked by noradrenaline in Ca2+-free solution. DBB completely inhibited the 45Ca2+ uptake induced by high KCl or noradrenaline. These results indicate that DBB inhibits the Ca2+ influx but not the Ca2+ release from the Ca2+ stores.
Abe
M
M
Department of Pharmacology, Tokyo College of Pharmacy, Japan.
Morikawa
M
M
Inoue
M
M
Nakajima
A
A
Tsuboi
M
M
Naito
T
T
Hosaka
K
K
Mitsuhashi
H
H
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001593:Benzyl Compounds / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D002122:Calcium Chloride / Q000494:pharmacology; D002132:Calcium Radioisotopes; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011817:Rabbits
D001593:Benzyl Compounds; D002132:Calcium Radioisotopes; C063012:2,3-dibenzylbutane-1,4-diol; D000804:Angiotensin II; D011189:Potassium Chloride; D002122:Calcium Chloride; D002118:Calcium; D009638:Norepinephrine