title: [Primary hyperparathyroidism and peptic ulcer].
abstract: The prevalence of peptic ulcer disease was retrospectively analysed in 35 patients affected by primary hyperparathyroidism consecutively observed from 1977 through 1987. Eight of the examined patients (22.8%) had peptic ulcer (7 duodenal and 1 gastric ulcer), that in five cases (14%) represented the first clinical manifestation of the endocrine disease. A Zollinger-Ellison syndrome was demonstrated in three cases (8.5% of the total series, 37% of the patients with ulcer). There was no difference in calcium, gastrin and parathormone serum level between patients with and without ulcer, excluding patients with Zollinger-Ellison syndrome. These data confirm the high prevalence of peptic ulcer disease in hyperparathyroidism, but the mechanism causing this association remains to be elucidated.
authors.affiliation: Divisione Medica I, Ospedale Civile, Montebelluna.
authors.forename: P
authors.initials: P
authors.lastname: Gasparoni
authors.forename: A
authors.initials: A
authors.lastname: Caroli
authors.forename: G
authors.initials: G
authors.lastname: Sardeo
authors.forename: S
authors.initials: S
authors.lastname: Maschio
authors.forename: C
authors.initials: C
authors.lastname: Lo Giudice
authors.forename: D
authors.initials: D
authors.lastname: Fioretti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000097:blood; D005260:Female; D005755:Gastrins / Q000097:blood; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010437:Peptic Ulcer / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology
chemical_list: D005755:Gastrins; D010281:Parathyroid Hormone; D002118:Calcium
vernacular_title: Iperparatiroidismo primitivo ed ulcera peptica.