In vitro immunologic features of Weimaraner dogs with neutrophil abnormalities and recurrent infections.
In vitro evaluation of cellular and humoral immunity in Weimaraner dogs with recurrent infections and abnormal neutrophil function revealed significantly lower serum immunoglobulin (Ig) G and M concentrations than control dogs. Lymphocyte blastogenesis in response to three different mitogens, interleukin-1 and -2 production, natural killer (NK) cell activity, and in vitro IgG and IgM production were similar to those of control dogs.
Couto
C G
CG
Department of Veterinary Clinical Sciences, Ohio State University, Columbus 43210.
Krakowka
S
S
Johnson
G
G
Ciekot
P
P
Hill
R
R
Lafrado
L
L
Kociba
G
G
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000662:veterinary*; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D017099:IgG Deficiency; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000172:deficiency; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000662:veterinary*; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D009504:Neutrophils / Q000276:immunology*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007375:Interleukin-1; D007376:Interleukin-2