Application of simulation modeling to lipid peroxidation processes.
A quantitative simulation model was developed that utilized present knowledge of lipid peroxidation in biological systems. The simulation model incorporated the following features: peroxidizability of polyunsaturated lipids, activation of inducers and their initiation of lipid peroxidation, concurrent autoxidation, inhibition of lipid peroxidation by vitamin E, reduction of some of the hydroperoxides by glutathione peroxidase, and formation of thiobarbituric acid-reactive substances. Simulation calculations were done using a computer spreadsheet program. When the simulation program was applied to tissue slice and microsomal peroxidizing systems, the results of the stimulation were in agreement with the experimental data.
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Department of Food Science and Technology, University of California, Davis 95616.
Tappel
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Fraga
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D001555:Benzene Derivatives / Q000378:metabolism; D003198:Computer Simulation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D010545:Peroxides / Q000378:metabolism
D001555:Benzene Derivatives; D010545:Peroxides; D000431:Ethanol; D003577:Cytochrome P-450 Enzyme System; C007164:cumene hydroperoxide