Localizing efficiency of [48V]vanadyl-pheophorbide in tumor as a new tumor imaging agent.
[48V]vanadyl-pheophorbide (48V-Pheo) was synthesized by insertion of 48V into pheophorbide (Pheo), a decomposition product from chlorophyll. At 24 h after injection, 48V-Pheo showed a clearer image of an FM3A tumor than inorganic 48V. This agent also accumulated in MH 134 and S 180 tumors as well as in FM3A tumors. The imaging efficiency was dependent on the affinity of Pheo for tumors. 48V-Pheo seems to be suitable as a tumor imaging agent in conjunction with photodynamic therapy.
Iwai
K
K
Laboratory of Nutrition, Faculty of Agriculture, Tohoku University, Sendai, Japan.
Ido
T
T
Iwata
R
R
Kawamura
M
M
Kimura
S
S
D000818:Animals; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D007553:Isotope Labeling / Q000379:methods; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012513:Sarcoma, Experimental / Q000000981:diagnostic imaging; D014018:Tissue Distribution; D014639:Vanadium
D009942:Organometallic Compounds; D011868:Radioisotopes; C063041:vanadyl pheophorbide complex; D014639:Vanadium; D002734:Chlorophyll