[Permanent decrease in immune function in patients with splenectomy for trauma].
The authors describe the peripheral blood analyses in patients splenectomized for trauma in consideration on the concentration of the immunoglobulins total complement CH50 levels, T and B lymphocyte populations and compare this with the control group. The levels of the IgM were significantly decreased (p0.001) in splenectomised while the levels of the IgA and IgG were significantly increased (for IgA - p0.001, for IgG p0.01). Total lymphocyte count averaged 54501999 in splenectomized, with number of T cells 2463930 and B lymphocyte 460236. The control group showed total lymphocyte count 460236. The control group showed total lymphocyte count 520235 (p0.001) with number of T cells 314147 (p0.001) and number of B cells 7434 (p0.001), what is significantly less than in splenectomized population. The level of total complement CH50 in splenectomized population was 11216 (p0.01), what is significantly less than in the control group 12515. These data demonstrate persistent abnormalities in immune function and suggest a possible explantation for the increased rizu of sepsis in this group of patients.
Kukoc
M
M
Sapunar
A
A
Vidjak
V
V
Aras
N
N
Grandić
L
L
Radonić
V
V
Matijević
M
M
D000293:Adolescent; D000328:Adult; D002648:Child; D015941:Complement Hemolytic Activity Assay; D005260:Female; D006801:Humans; D007109:Immunity; D007136:Immunoglobulins / Q000032:analysis; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000293:injuries*; D013156:Splenectomy / Q000009:adverse effects*
D007136:Immunoglobulins
Dugotrajno smanjena imuna funkcija kod pacijenata splenektomiranih zbog traume.