[Familial hyperthyroxinemia with dysalbuminemia: screening of 21,000 patients at the occasion of thyroid evaluation].
Serum samples from 21,342 patients undergoing evaluation of thyroid status were screened for familial dysalbuminemic hyperthyroxinemia (FDH) using a specific test based on the measure of charcoal uptake of 125I thyroxine (T4) from serum diluted 1:100 with addition of unlabelled 10(-6) M T4. We found 17 cases of FDH: a higher incidence (8:10,000) than previously reported in the general population (1:10,000). The results of thyroid function tests of patients with FDH are presented: total T4 concentration is increased in only 14 subjects; thyrotropin and free T4 measured by an immunoextraction method are the most useful assays to evaluate the clinical status of these patients.
Sapin
R
R
Institut de Physique Biologique, Faculté de Médecine, Université Louis-Pasteur, Strasbourg, France.
Gasser
F
F
Chambron
J
J
D006801:Humans; D006981:Hyperthyroxinemia / Q000097:blood / Q000150:complications / Q000235:genetics*; D008403:Mass Screening; D012709:Serum Albumin / Q000172:deficiency*; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D012709:Serum Albumin; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine
Hyperthyroxinémie familiale avec dysalbuminémie: dépistage sur 21,000 patients a l'occasion d'un bilan thyroïdien.