[Nickel-induced allergic contact dermatitis: reactivation by oral administration of hapten].
Recent reports suggest the high frequency of nickel induced allergic contact dermatitis and the absence in some patients of a clinical improvement following topical avoidance of sensitising allergen. In this study we evaluated the role of food ingested nickel in the maintenance and exacerbations of the disease. A high frequency of cutaneous exacerbations was obtained after oral challenge with a low nickel containing diet. These results suggest a pathogenetic role of nickel present in foods and indicate that an appropriate diet may be useful in the prophylaxis and in the therapy of nickel dermatitis in sensitized patients.
Bezze
G
G
Cassin
E
E
Borghesan
F
F
Fagiolo
U
U
D003877:Dermatitis, Contact / Q000209:etiology* / Q000517:prevention & control; D004032:Diet; D005260:Female; D005512:Food Hypersensitivity / Q000209:etiology*; D006801:Humans; D008297:Male; D009532:Nickel / Q000008:administration & dosage / Q000009:adverse effects*
D009532:Nickel
Dermatite allergica da contatto al nichel: riacutizzazione mediante somministrazione dell'aptene per via orale.