[The structural bases of liver cell aging and age-related characteristics of their reactivity].
The liver of the 8-, 24-, 30- and 38-month-old Wistar male rats were studied morphometrically in the light and electron microscope under normal conditions and after bleeding and enterosorption. Under both conditions--ageing and bleeding--the hepatocyte death (apoptosis and colliquative necrosis) occurs resulting from the progression of granular and hydropic degeneration. Apoptosis develops mainly in the 1st zone and necrosis in the 3rd zone of the liver acinus this being due to the pattern of blood supply. The hepatocyte death through the apoptosis is followed by immunocompetent cell response. Compensatory processes in ageing are manifested in the hepatocyte hypertrophy this being due to the hyperplasia of cytoplasmatic structures, smooth cytoplasmic network particularly.
Berezhkov
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NV
D000327:Adsorption; D000375:Aging; D000818:Animals; D002470:Cell Survival; D002606:Charcoal / Q000008:administration & dosage; D006470:Hemorrhage / Q000473:pathology; D006965:Hyperplasia / Q000473:pathology; D006984:Hypertrophy / Q000473:pathology; D008099:Liver / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D009336:Necrosis / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002606:Charcoal
Strukturnye osnovy stareniia kletok pecheni i vozrastnye osobennosti ikh reaktivnosti.