Liposomes prepared from synthetic amphiphiles. I. Their technetium labeling and stability.
In order to apply liposomes prepared from synthetic amphiphiles containing amino acid residues to radiopharmaceuticals, their labeling with 99Tc or 99mTc and stability in saline or in serum were investigated. These liposomes were highly labeled by embedding stearylamine-diethylenetriamine pentaacetic acid as a ligand of technetium. The labeling was more efficient at pH 7.0 than at pH 4.0 or 8.5. Among these technetium-labeled liposomes tested, liposomes containing the alanine residue were stable in saline or in 50% serum at 37 degrees C for at least 24 h, in contrast to liposomes (phosphatidylcholine: cholesterol = 1:1 molar ratio) whose stability had been enhanced by adding cholesterol.
Goto
R
R
Kubo
H
H
Okada
S
S
D055598:Chemical Phenomena; D002621:Chemistry; D007553:Isotope Labeling; D008081:Liposomes / Q000032:analysis / Q000138:chemical synthesis*; D010316:Particle Size; D013667:Technetium
D008081:Liposomes; D013667:Technetium