Ceftriaxone versus cefotaxime in the treatment of septicemia in adults.
Two potent third-generation cephalosporins with similar antibacterial spectra but different pharmacokinetics were compared in patients suffering from septicemia due to different organismus. Sixty patients with a variety of underlying diseases were included in the study. They received either 2-4 g ceftriaxone (active ingredient of Rocephin) once a day or 2 g cefotaxime every 8 h for 10-15 days. Our data confirm that a single dose of 2 g ceftriaxone should be sufficient to treat septicemia.
Ferencz
A
A
Central Municipal Hospital for Infectious Diseases, Budapest, Hungary.
Prinz
G
G
Szalka
A
A
Ban
E
E
D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy*; D002423:Cause of Death; D002439:Cefotaxime / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D018805:Sepsis / Q000188:drug therapy*
D002443:Ceftriaxone; D002439:Cefotaxime