[NMR identification and stereoisomeric purity determination of HM-PAO diastereoisomers].
1H and 13C NMR spectra of d,l- and meso-HM-PAO in different solvents were studied at different resonance frequencies. The 1HNMR spectra of two diastereoisomers are the same in dimethyl sulfoxide and acetone, but different in chloroform. The 13C NMR spectra are different in dimethyl sulfoxide and chloroform. The different 1H and 13C NMR spectra can be used to identify and differentiate these two diastereoisomers. It is also shown that the d,l-HM-PAO stereoisomeric purity in a mixture of these two isomeric forms can be determined with sufficient accuracy by using 13C peak areas or heights of their C(5) and C(7) in a routine noise decoupling 13C spectrum of the mixture.
Wen
J Q
JQ
Wang
J Z
JZ
Shao
L R
LR
D009682:Magnetic Resonance Spectroscopy; D015609:Organotechnetium Compounds; D010091:Oximes; D013237:Stereoisomerism; D019690:Technetium Tc 99m Exametazime
D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime