title: Cerebral regulation of renal sodium excretion in sheep infused intravenously with hypertonic NaCl.
abstract: 1. The natriuretic response to intravenous infusion of 2 M-NaCl was investigated in six conscious sheep. This hypertonic NaCl load resulted in relatively small, physiological (2-3 mmol l-1) increases in plasma Na+ concentration and was followed by a natriuresis with a maximum mean urinary sodium excretion 5 times higher than pre-infusion values. 2. Intravenous infusion of isotonic NaCl, delivering the same Na+ load as hypertonic NaCl infusion, did not induce natriuresis. This suggested, therefore, that with the hypertonic sodium load administered in the present study, the rise in plasma Na+ and/or tonicity rather than increase in blood volume is important in evoking the natriuretic response. 3. Intracerebroventricular infusion of low-Na+ artificial cerebrospinal fluid (CSF) reduced CSF Na+ concentration, decreased plasma vasopressin (AVP) levels and caused a copious water diuresis. This was associated with excessive loss of water and large increases in plasma Na+ concentration and osmolality. 4. The natriuresis induced by intravenous hypertonic NaCl load could be blocked by lowering CSF Na+ concentration in situations where water diuresis was either prevented or reduced by intravenous infusion of AVP or by delayed intracerebroventricular infusion of low-Na+ CSF, respectively. 5. The results of the present study provide further evidence that renal sodium excretion can be controlled by the central nervous system.
authors.affiliation: Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Chodobski
authors.forename: M J
authors.initials: MJ
authors.lastname: McKinley
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D001810:Blood Volume / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D005260:Female; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D009318:Natriuresis / Q000187:drug effects / Q000502:physiology*; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage; D012756:Sheep; D012964:Sodium / Q000097:blood / Q000134:cerebrospinal fluid
chemical_list: D012462:Saline Solution, Hypertonic; D001127:Arginine Vasopressin; D012964:Sodium