Reproductive activity is a magic spell to connect the genesis of cancers of the uterine cervix and endometrium.
The present study investigated the relation between the reproductive activity and the risk for cervical and endometrial cancers using both domestic and international materials. An association of increased risk for cervical cancer (C) with fertility at the levels of both an individual and a population was contrasted to another association of increased risk for endometrial cancer (E) with infertility at the same two levels. Both C and E patients experienced a delay of menstrual cycle (over 30 days) at high incidences (35-49%), whereas healthy controls and breast cancer patients were essentially free from such menstrual delay. The possible impact of the above hormonal characteristics of C and E patients on uterine carcinogenesis is discussed in the light of comparative endocrinology.
Kodama
M
M
Kodama Research Institute of Preventive Medicine, Nagoya, Japan.
Murakami
M
M
Kodama
T
T
D000367:Age Factors; D005260:Female; D005298:Fertility; D006801:Humans; D008593:Menopause; D009656:North America; D012042:Registries; D012098:Reproduction; D012307:Risk Factors; D013020:South America; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000209:etiology*; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000209:etiology*