Oxygen therapy and vasodilator therapy in patients with chronic lung disease: the effects of episodic pulmonary hypertension during sleep and exercise performance.
In patients with chronic lung disease, we estimated the effectiveness of nocturnal oxygen therapy in eliminating episodes of sleep hypoxemia and concomitant elevations in the pulmonary arterial pressure. We also assessed the effect of vasodilators (ISDN, nifedipine) in improving exercise tolerance. Our results support the efficacy of nocturnal oxygen therapy. Vasodilators examined were not confirmed as effective or safe for wide use.
Sawada
M
M
3rd Department of Internal Medicine, Osaka Prefectural Habikino Hospital, Japan.
D001794:Blood Pressure; D002908:Chronic Disease; D005080:Exercise Test; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D007548:Isosorbide Dinitrate / Q000627:therapeutic use; D008171:Lung Diseases / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D009543:Nifedipine / Q000627:therapeutic use; D010101:Oxygen Consumption; D010102:Oxygen Inhalation Therapy; D011652:Pulmonary Circulation / Q000187:drug effects; D011660:Pulmonary Heart Disease / Q000503:physiopathology / Q000628:therapy; D012890:Sleep; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000628:therapy; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents; D009543:Nifedipine; D007548:Isosorbide Dinitrate