title: Recursive descent probabilities for rare recessive lethals.
abstract: Recursively computed descent probabilities provide an effective way to evaluate possible ancestries of rare alleles segregating in large and complex genealogies, but they ignore information other than the descent to a small set of current gene copies. We show how descent probability computations can be modified to incorporate the fact that no ancestor can be affected by a lethal recessive trait. This methodology is applied to two rare recessive traits segregating in a complex Hutterite (Lehrerleut) genealogy.
authors.affiliation: Department of Statistics GN-22, University of Washington, Seattle 98195.
authors.forename: E A
authors.initials: EA
authors.lastname: Thompson
authors.forename: K
authors.initials: K
authors.lastname: Morgan
mesh_terms: D000483:Alleles; D005006:Ethnicity; D005260:Female; D005804:Genes, Lethal; D005808:Genes, Recessive; D006801:Humans; D008297:Male; D010375:Pedigree; D011336:Probability