title: [Impairment of energy metabolism in rabbit tissues during ammonia toxicosis].
abstract: The studies are conducted on the model of grave toxicosis in vivo in rabbits. It is shown that an increase in the ammonia content in blood and tissues enhances the content of lactate, glutamate, oxaloacetate in the liver and kidneys of animals, decreases the level of pyruvate, alpha-ketoglutarate and malate in the liver tissue. The NAD+/NADH ratio in the cytoplasm of the liver and kidney cells decreases, the ratio of NADP-pairs in the cytoplasm and mitochondria of these tissues noticeably increases. The energy metabolism is disturbed sharply, the content of adenosine phosphates lowers.
authors.forename: O N
authors.initials: ON
authors.lastname: Makarenko
authors.forename: D A
authors.initials: DA
authors.lastname: Mel'nichuk
authors.forename: L V
authors.initials: LV
authors.lastname: Skorik
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism; D000641:Ammonia / Q000633:toxicity*; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D011817:Rabbits
chemical_list: D000227:Adenine Nucleotides; D009249:NADP; D000641:Ammonia; D010088:Oxidoreductases
vernacular_title: Narushenie énergeticheskogo obmena v tkaniakh krolika pri ammoniĭnom toksikoze.