Acute histopathological response to a new biodegradable polypeptidic polymer for implantable drug delivery system.
This article deals with the in vivo evaluation of a new class of synthetic polypeptides, the poly[(tert-butyloxycarbonylmethyl) glutamates], POMEG, as an injectable or implantable drug delivery system. Three different polymers, varying in their degree of esterification, were extruded either with or without progesterone, and finally implanted in rats up to 14 days. Histologic evaluation of the implant sites show evidence of the good biocompatibility of these polymers. In addition, the description of their in vivo behavior, based on microscopic observation of the implanted POMEG rods, enables one to appreciate their potential as a drug delivery system for short- or long-term therapy.
Lescure
F
F
School of Pharmacy, University of Geneva, Switzerland.
Gurny
R
R
Doelker
E
E
Pelaprat
M L
ML
Bichon
D
D
Anderson
J M
JM
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002725:Chloroform / Q000032:analysis; D004343:Drug Implants / Q000494:pharmacology*; D000431:Ethanol / Q000032:analysis; D005069:Evaluation Studies as Topic; D007249:Inflammation / Q000473:pathology*; D015918:Infusion Pumps, Implantable; D008297:Male; D008422:Materials Testing; D009132:Muscles / Q000187:drug effects / Q000473:pathology; D009842:Oligopeptides / Q000032:analysis / Q000138:chemical synthesis / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing / Q000187:drug effects*
D004343:Drug Implants; D009842:Oligopeptides; C062244:poly(tert-butyloxycarbonylmethyl)glutamate; D000431:Ethanol; D011374:Progesterone; D002725:Chloroform