[The effect of disulfiram on lipid metabolism in the rat liver].
Administration of disulfiram (200 mg/kg intragastrically for 3 days) was followed by an increase in the rat liver contents of total phospholipid fraction, triacylglycerine, lisophosphatidylcholine and a decrease in the relative level of phosphatidylethanolamine. This was associated with a decrease in the involvement of the tracer from 14C-ethanol in triacylglycerines, total phospholipids, lisophosphatidylcholine and cardiolipin. Alcohol injection (a 20% solution intraperitoneally in a dose of 1 g/kg for 30 minutes) against the background of treatment with disulfiram leads, in addition to the above-mentioned changes, to an increase of phosphatidylcholine concentration, a decrease of specific radioactivities of cholesterol, diacylglycerine and sphyngomyelin.
Selevich
M I
MI
Karaedova
L M
LM
Ostrovskiĭ
Iu M
IuM
D000818:Animals; D002250:Carbon Radioisotopes; D004221:Disulfiram / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats
D002250:Carbon Radioisotopes; D008055:Lipids; D000431:Ethanol; D004221:Disulfiram
Vliianie disul'firama na metabolizm lipidov v pecheni krys.