[The subcellular distribution and covalent binding of 3H-(+) and 3H-(-) gossypol in the main tissues of rats].
The total and covalently bound radioactivity in various subcellular components in the main tissues of rats was measured 7 and 18 days after a single intraperitoneal and intratesticular injection of 3H-(+) and 3H-(-) gossypol. An increasing tendency of covalently bound radioactivity with time in the myocardial mitochondria and testicular cell membrane and microsomes of rats treated with (+) or (-) gossypol was found, especially in (-) gossypol treated rats. It remains to be clarified whether these are linked to the myocardial toxicity and to the antispermatogenic activity of gossypol.
Deng
H L
HL
Yu
Y W
YW
Wu
D F
DF
Yi
M G
MG
D000818:Animals; D006072:Gossypol / Q000493:pharmacokinetics*; D007274:Injections, Intraperitoneal; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013347:Subcellular Fractions / Q000378:metabolism; D013737:Testis / Q000378:metabolism*; D014018:Tissue Distribution; D014316:Tritium
D014316:Tritium; D006072:Gossypol