[The activity of the liver monooxygenase system in workers in contact with inorganic substances (metals, fluorine)].
The liver monooxygenase system activity was studied in 100 workers by measuring the half-life period of antipyrine and its clearance from saliva. The examined contacted with lead (22 cases), vanadium (11 cases), manganese (14 cases), fluorine (53 cases). In average, in a half of those examined the antipyrine half-life period shortened to less than 10 hours. The contributors hold that the new technique of functional examination of the liver can hardly be applied to for diagnosing toxic affections of the liver. Anyhow the technique demonstrates that metals contribute to liver monooxygenase, which, in case of a combined effect, can increase metabolism of other compounds.
Lobchenko
P N
PN
Levchenko
N I
NI
Bendikov
E A
EA
Kornilaeva
N A
NA
D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D005461:Fluorine / Q000009:adverse effects*; D006207:Half-Life; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008107:Liver Diseases / Q000201:enzymology; D008111:Liver Function Tests / Q000379:methods; D008297:Male; D008670:Metals / Q000009:adverse effects*; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000201:enzymology; D010105:Oxygenases / Q000378:metabolism*
D000395:Air Pollutants, Occupational; D008670:Metals; D005461:Fluorine; D010105:Oxygenases
Aktivnost' monooksigenaznoĭ sistemy pecheni u rabochikh, kontaktruiushchikh s neorganicheskimi veshchestvami (metallami, ftorom).