Intraocular penetration of cytosine arabinoside following subconjunctival administration in primates.
Cytosine arabinoside was administered subconjunctivally to three monkeys. Blood, aqueous, and vitreous specimens were collected after 30 minutes, 1 hour, 2 hours, and 3 hours. Intraocular drug concentrations appeared stable or increasing over this time period while intravenous levels were relatively low. The results of this study suggest that therapeutic intraocular concentrations of cytosine arabinoside are obtained following subconjunctival administration in primates with lower, nontoxic intravenous levels during this time.
Graham
M L
ML
Pediatric Oncology Service, Johns Hopkins Medical Institute, Baltimore, Maryland.
Smiddy
W E
WE
Cheo
D L
DL
Schachat
A P
AP
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D003228:Conjunctiva / Q000187:drug effects*; D003561:Cytarabine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004333:Drug Administration Routes; D008252:Macaca fascicularis; D014822:Vitreous Body / Q000378:metabolism
D003561:Cytarabine