title: Comparative study of pentoxifylline vs antiaggregants in patients with transient ischaemic attacks.
abstract: Out of 235 patients with recent cerebral transient ischaemic attacks, 208 subjects were available for final evaluation after 6 months' randomised treatment with either pentoxifylline (PTX 1200 mg/day) or a combination (ASAD) of acetylsalicylic acid (ASA, 1050 mg/day) and dipyridamole (D, 150 mg/day). Prevention of TIA, stroke or death attributable to previous events were endpoint criteria. The pentoxifylline group (n = 100) exhibited no recurrent episodes in 86 patients (86%). TIA occurred in 9 patients, stroke in 5 patients and there was 1 death. In the ASAD group (n = 108) no recurrence of ischaemic episodes was recorded in 82 cases (75.9%). TIA occurred in 20 patients, stroke in 6 patients and there were 3 deaths of vascular origin. Side effects were recorded in 4 ASAD and 1 PTX patients. The total rate of recurrence was 14% with PTX as compared to 24.1% with ASAD treatment.
authors.affiliation: Neurology Division of Hospitals Juan A. Fernández, Buenos Aires, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Herskovits
authors.forename: A
authors.initials: A
authors.lastname: Famulari
authors.forename: L
authors.initials: L
authors.lastname: Tamaroff
authors.forename: A M
authors.initials: AM
authors.lastname: Gonzalez
authors.forename: A
authors.initials: A
authors.lastname: Vzquez
authors.forename: R
authors.initials: R
authors.lastname: Dominguez
authors.forename: H
authors.initials: H
authors.lastname: Fraiman
authors.forename: J
authors.initials: J
authors.lastname: Vila
authors.forename: V
authors.initials: V
authors.lastname: Benjamin
authors.forename: V
authors.initials: V
authors.lastname: Matera
mesh_terms: D000368:Aged; D001241:Aspirin / Q000627:therapeutic use*; D004176:Dipyridamole / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D013805:Theobromine / Q000031:analogs & derivatives*
chemical_list: D010975:Platelet Aggregation Inhibitors; D004176:Dipyridamole; D013805:Theobromine; D001241:Aspirin; D010431:Pentoxifylline