Alterations in cardiopulmonary receptors in hypertensive patients with impaired left ventricular filling.
We examined the response of total peripheral resistance to low levels of lower-body negative pressure (-15 to -20 mmHg) in two groups of hypertensive patients, one with a reduced index of left ventricular filling and the other with normal left ventricular filling characteristics. These groups were compared with a group of normal volunteers of the same age range. Total peripheral resistance increased significantly from corresponding baseline values both in the normal volunteers and in the hypertensives with a normal diastolic function, but the hypertensives with a decreased diastolic function showed a non-significant change in total peripheral resistance. We suggest that left ventricular diastolic dysfunction in hypertension may be associated with an impairment in cardiopulmonary reflexes, and therefore may influence peripheral vascular regulation.
Madkour
M A
MA
Department of Heart and Hypertension Research, The Cleveland Clinic Foundation, Ohio 44195-5069.
Fouad-Tarazi
F M
FM
D000328:Adult; D000368:Aged; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008150:Lower Body Negative Pressure; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011311:Pressoreceptors / Q000503:physiopathology*; D012021:Reflex, Abnormal / Q000502:physiology*; D014655:Vascular Resistance / Q000502:physiology