Autosomal dominant retinitis pigmentosa (ADRP): localization of an ADRP gene to the long arm of chromosome 3.
Members of a large pedigree of Irish origin presenting with early onset Type I autosomal dominant retinitis pigmentosa (ADRP) have been typed for D3S47 (C17), a polymorphic marker from the long arm of chromosome 3. Significant, tight linkage of ADRP to D3S47, with a lod score of 14.7 maximizing at 0.00 recombination, has been obtained, hence localizing the ADRP gene (RP1) segregating in this pedigree to 3q.
McWilliam
P
P
Department of Genetics, Trinity College Dublin, Ireland.
Farrar
G J
GJ
Kenna
P
P
Bradley
D G
DG
Humphries
M M
MM
Sharp
E M
EM
McConnell
D J
DJ
Lawler
M
M
Sheils
D
D
Ryan
C
C
D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D012174:Retinitis Pigmentosa / Q000235:genetics*
D005819:Genetic Markers