Possible role of Tamm-Horsfall glycoprotein in calcium oxalate crystallisation.
The role of Tamm-Horsfall glycoprotein (THGP) in the crystallisation of calcium oxalate was investigated. The results showed THGP to have a weak inhibitory effect on crystal growth. In contrast, urinary macromolecules showed a strong inhibitory effect. THGP should, therefore, not be considered the main component of urinary macromolecules which have a strong inhibitory effect on crystal growth. However, THGP did enhance crystal production in the early phase of crystallisation. It appears that THGP should be viewed as a promoter rather than an inhibitor of calcium oxalate crystallisation at physiological concentrations.
Yoshioka
T
T
Department of Urology, Osaka University Medical School, Japan.
Koide
T
T
Utsunomiya
M
M
Itatani
H
H
Oka
T
T
Sonoda
T
T
D000328:Adult; D002129:Calcium Oxalate / Q000652:urine*; D003460:Crystallization; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009088:Mucoproteins / Q000494:pharmacology*; D014545:Urinary Calculi / Q000209:etiology; D058949:Uromodulin
D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin; D002129:Calcium Oxalate