Prophylactic effects of m-nisoldipine and nisoldipine on reperfusion arrhythmias exacerbated by free radical generating system in Langendorff heart of rat.
Xanthine-xanthine oxidase (X-XOD, 500 mumol/L + 100 nmol/L) free radical generating system was perfused 10 min prior to coronary artery ligation until the end of the experiment. It exacerbated the reperfusion ventricular fibrillation, reduced the activities of superoxide dismutase and catalase and increased the contents of malondialdehyde in Langendorff heart of rats. m-Nisoldipine or nisoldipine (0.05 mumol/L) was perfused 10 min prior to coronary artery ligation until the end of the experiment. They prevented reperfusion arrhythmias exacerbated by X-XOD and decreased the free radicals generated by X-XOD.
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D000818:Animals; D001145:Arrhythmias, Cardiac / Q000517:prevention & control*; D005609:Free Radicals; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D015737:Nisoldipine / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D014665:Vasodilator Agents / Q000627:therapeutic use*
D005609:Free Radicals; D014665:Vasodilator Agents; D015737:Nisoldipine