title: Monoclonal antibody (OKT3) rescue in refractory acute renal allograft rejection: report of 3 cases.
abstract: We report the first experience in Thailand with the use of OKT3 (monoclonal anti T lymphocyte antibody) in rescuing an acute rejection unresponsive to methylprednisolone pulses in 3 cadaveric renal transplant patients. The treatment regimen was 10 daily 5 mg intravenous injections of OKT3. In the first and second patients OKT3 was started on days 26 and 18 of the rejection episode. In the third one OKT3 was given when he became anuric secondary to severe acute rejection. Within 24 hours of the therapy, urine flow increased. A brisk diuresis and a decline in serum creatinine started within 4 days. The kidney function returned to normal within the 10-day course of therapy. Side effects were fever, conjunctivitis, stuffiness of nose and herpes infection.
authors.forename: R
authors.initials: R
authors.lastname: Suvanapha
authors.forename: S
authors.initials: S
authors.lastname: Laorpatanaskul
authors.forename: R
authors.initials: R
authors.lastname: Vajaraphongse
authors.forename: P
authors.initials: P
authors.lastname: Kitisin
authors.forename: V
authors.initials: V
authors.lastname: Srivatanawongsa
authors.forename: S
authors.initials: S
authors.lastname: Mulikamas
authors.forename: K
authors.initials: K
authors.lastname: Vajaraphongse
authors.forename: S
authors.initials: S
authors.lastname: Boonvisut
authors.forename: S
authors.initials: S
authors.lastname: Chusil
authors.forename: W
authors.initials: W
authors.lastname: Panmuong
mesh_terms: D000208:Acute Disease; D000328:Adult; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use*; D006084:Graft Rejection / Q000187:drug effects*; D006801:Humans; D007239:Infections / Q000150:complications; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D013785:Thailand; D014184:Transplantation, Homologous
chemical_list: D000911:Antibodies, Monoclonal