title: Analysis of lymphocyte response to chironomid midge antigens in asthmatic and non-asthmatic individuals.
abstract: Chironomid antigens are currently one of the important allergens for bronchial asthma in Japan. We evaluated in vitro responses of peripheral blood lymphocytes (PBLs) to chironomid antigens and compared these responses with serum IgE levels. PBLs from adult asthmatic patients showed stronger proliferation in response to the extract of adult midges of Chironomus yoshimatsui compared with healthy adults. On the other hand, elevated PBL responses of child asthmatic patients to chironomid antigens were not observed. There was no significant correlation between PBL proliferation and the serum IgE level. Our results might suggest that elevated PBL proliferation in response to chironomid allergens has somehow important pathogenic roles in adult cases although this does not correlate directly with specific IgE production.
authors.affiliation: Department of Parasitology, Okayama University Medical School.
authors.forename: T
authors.initials: T
authors.lastname: Edahiro
authors.forename: N
authors.initials: N
authors.lastname: Ohta
authors.forename: H
authors.initials: H
authors.lastname: Matsuoka
authors.forename: A
authors.initials: A
authors.lastname: Ishii
authors.forename: Y
authors.initials: Y
authors.lastname: Tanizaki
authors.forename: H
authors.initials: H
authors.lastname: Kitani
authors.forename: T
authors.initials: T
authors.lastname: Kunitomi
authors.forename: S
authors.initials: S
authors.lastname: Noono
authors.forename: K
authors.initials: K
authors.lastname: Tachibana
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology*; D002478:Cells, Cultured; D002683:Chironomidae / Q000276:immunology*; D004175:Diptera / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000096:biosynthesis*; D066298:In Vitro Techniques; D007564:Japan; D008213:Lymphocyte Activation / Q000276:immunology*; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E