title: Outcome of early detected and early treated phenylketonuria patients.
abstract: Data from the US PKU Collaborative Study are reviewed and compared with data from UK and the rest of Europe in order to assess the outcome of dietary management. Early treated phenylketonuria (PKU) children have a good outcome. However, to achieve this the diet needs to be fairly strict for at least the first 10 years of life and perhaps should be maintained for a long period subsequently. Lifelong dietary management may be beneficial. PKU individuals in general have slightly lower IQ than their normal siblings and there is a greater tendency to display difficulty in mathematics and conceptual thinking.
authors.affiliation: Children's Hospital, Ladywood Middleway, Birmingham, UK.
authors.forename: G
authors.initials: G
authors.lastname: Rylance
mesh_terms: D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007360:Intelligence / Q000502:physiology*; D010649:Phenylalanine / Q000008:administration & dosage*; D010661:Phenylketonurias / Q000175:diagnosis / Q000178:diet therapy*
chemical_list: D010649:Phenylalanine