[Reduction of renal reperfusion damage following warm ischemia by allopurinol and superoxide dismutase].
Preserved organs are damaged not only by the ischemic injury due to lack of oxygen. The reperfusion injury mediated by oxygen free radicals is an important factor in the postischemic organ failure. The prevention of free radical-induced reperfusion injury with allopurinol (AP) and superoxide dismutase (SOD) is shown in a warm ischemia kidney model. Rats were treated with allopurinol (40 mg/kg i.v.) one hour, or with SOD (20,000 IU/kg i.v.) one minute before reperfusion after a period of 35 minutes of warm ischemia. Allopurinol and SOD reduced significantly the postischemic kidney failure with a less important increase of creatinine. Creatinine levels on day three in the control group: 517 +/- 87 mumol/ml, in the SOD-group: 206 +/- 105 mumol/ml, and in the AP-group: 163 +/- 81 mumol/ml (anal. of variance: p = 0.0001). AP has a wide therapeutic range. We feel, that it is important to confirm the prevention of reperfusion injury by allopurinol prophylaxis clinically.
Marx
A
A
Heberer
M
M
Gale
J
J
Landmann
J
J
D000493:Allopurinol / Q000008:administration & dosage*; D000818:Animals; D003404:Creatinine / Q000097:blood; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000008:administration & dosage*
D000493:Allopurinol; D003404:Creatinine; D013482:Superoxide Dismutase
Reduktion des renalen Reperfusionsschadens nach warmer Ischämie durch Allopurinol und Superoxiddismutase.