[Effect of essential phospholipids (EPL) on the course of chronic poisoning with organic solvents in rats].
Male Wistar rats were exposed in toxicological camera to the mixture of organic solvents. Composition and concentrations of the mixture were similar to the conditions in the production hall. The influence of essential phospholipids (EPL) on changes in the liver caused by the organic solvents were studied. Animals were exposed for 6 months. Histochemical and histological evaluation was performed after 2 and 6 months. In the liver of intoxicated animals marked vacuolar degeneration and diminution of glycogen contents were observed. Simultaneously, the protective effect of EPL was noted. It was expressed by distinctly decreased vacuolar degeneration, probably corresponding to neutral fat in hepatocytes as well as by normalization of glycogen contents.
Put
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Z Zakładu Toksykologii Instytutu Farmakologii i Toksykologii PAM w Szczecinie.
Samochowiec
L
L
Wyczarska-Szok
K
K
Wójcicki
J
J
D000818:Animals; D000931:Antidotes; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D006838:Hydrocarbons / Q000037:antagonists & inhibitors / Q000506:poisoning*; D008099:Liver / Q000187:drug effects*; D008297:Male; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012997:Solvents / Q000506:poisoning*
D000931:Antidotes; D006838:Hydrocarbons; D010713:Phosphatidylcholines; D012997:Solvents; C011246:essential 303 forte
Wpływ niezbednych fosfolipidów (EPL) na przebieg przewlekłego zatrucia rozpuszczalnikami organicznymi u szczurów.