Effect of gossypol on few testicular enzymes in mature rats.
Effect of oral administration of gossypol acetic acid (15 mg/kg/day) for 10 weeks, on certain enzymes, which may be taken as markers for the different stages of spermatogenesis, was studied in male albino rats. Gossypol produced a significant decrease in hyaluronidase and sorbitol dehydrogenase, while no change was observed in beta-glucuronidase and acid phosphatase. A significant increase in the total lactate dehydrogenase activity was observed in the testis. The possible significance of these findings is discussed.
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D000818:Animals; D005966:Glucuronidase / Q000378:metabolism; D006072:Gossypol / Q000494:pharmacology*; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000201:enzymology
D007064:L-Iditol 2-Dehydrogenase; D007770:L-Lactate Dehydrogenase; D005966:Glucuronidase; D006821:Hyaluronoglucosaminidase; D006072:Gossypol