Neurological disorders in Nigerian children with homozygous sickle cell anaemia.
The pattern of associated Central Nervous System (CNS) disorders in children with homozygous sickle cell anaemia was studied over a 12-month period at the University of Nigeria Teaching Hospital (UNTH), Enugu. The relative incidence of associated neurological disorders was 1.3%, and the major varieties were cerebrovascular accidents (57.5%), meningitis (22.5%) and recurrent convulsions (10%). Intellectual impairment did not feature as a separate entity, but was observed in 27.5% of children with CNS complications. Although recurrent strokes were not frequently encountered, the hypertransfusion therapy was not practised because of relative scarcity of blood donors.
Izuora
G I
GI
Kaine
W N
WN
Emodi
I
I
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications*; D002493:Central Nervous System Diseases / Q000453:epidemiology* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009549:Nigeria / Q000453:epidemiology