[Ultrastructural analysis of collagen fibers in the conductive and working myocardium of the sinoatrial region of the human heart].
Qualitative and quantitative electron microscopic analysis of collagenous fibers has been performed in the sinusal node (SN) and perinodal working myocardium of the right atrium (RA) in the hearts of 22 men, died at the age of 23-63 years. Five of them died from alcoholic cardiomyopathy, 8--from coronary cardiac disease and 9--from noncardiac causes and craniocerebral trauma (group of comparison). In 21 cases seven types of ultrastructural changes of the collagenous fibers have been revealed in the SN (changes in the form, size and degree of their osmiophilia). As a whole the volumetric density of the collagenous fibers in the selection makes 24.4 +/- 1.6% from the volume of the SN conductive myocardium and 5.7 +/- 0.8% from the volume of the RA perinodal working myocardium. Content of the collagenous fibers in the SN does not depend on the death cause, age of the dead or on degree of the cardiac hypertrophy. Content of the collagenous fibers in the RA is 2.2 times higher at a sudden coronary death, than in the group of comparison. With age in the RA the volumetric density of the collagenous fibers increases by 1.9 times, and with rise in the cardiac mass, it increases by 2.2 times. The data obtained are discussed in order to understand the role of the collagenous fibers in functioning of the sinoauricular area both normal and at the cardiac pathology.
Pavlovich
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D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000473:pathology; D002310:Cardiomyopathy, Alcoholic / Q000473:pathology; D003094:Collagen / Q000648:ultrastructure*; D003327:Coronary Disease / Q000473:pathology; D006325:Heart Atria; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009206:Myocardium / Q000648:ultrastructure*; D012849:Sinoatrial Node / Q000648:ultrastructure*
D003094:Collagen
U'ltrastrukturnyĭ analiz kollagenovykh volokon provodiashchego i rabochego miokarda sinoaurikuliarnoĭ oblasti serdtsa cheloveka.