The human genes for calbindin 27 and 29 kDa proteins are located on chromosomes 8 and 16, respectively.
Genomic clones coding for the brain calcium-binding protein, calbindin 29 kDa, were isolated from a human library. A fragment containing exon 2 was used as a probe to investigate the presence of the gene in human x rodent somatic cell hybrids. The gene was unambiguously assigned to chromosome 16. The closely-related calbindin 27 kDa gene was previously assigned to chromosome 8. These two genes, deriving from a common ancestor, thus appear to have been separated during vertebrate evolution.
Parmentier
M
M
I.R.I.B.H.N., Medical School, Université Libre de Bruxelles, Brussels, Belgium.
Szpirer
J
J
Levan
G
G
Vassart
G
G
D000818:Animals; D015139:Blotting, Southern; D064026:Calbindins; D002885:Chromosomes, Human, Pair 16; D002898:Chromosomes, Human, Pair 8; D003001:Cloning, Molecular; D015723:Gene Library; D006801:Humans; D006822:Hybrid Cells; D008970:Molecular Weight; D015183:Restriction Mapping; D064030:S100 Calcium Binding Protein G / Q000235:genetics*
D064026:Calbindins; D064030:S100 Calcium Binding Protein G