[Effects of amrinone in myocardial insufficiency following heart surgery in children].
11 infants and children with severe congestive heart failure after cardiac surgery were treated with Amrinone. Cardiac and circulatory effects were monitored by quantitative echocardiography and blood pressure measurements. Within 1 day after the initial dose ventricular ejection fractions (EF) increased. Left ventricle: EF = 0.35 +/- 0.06 to EF = 0.49 +/- 0.06; right ventricle: EF = 0.30 +/- 0.12 to EF = 0.56 +/- 0.12. Vascular resistance dropped from R = 1527 +/- 517 dyn.s.cm-5.m2 to R = 1071 +/- 399 dyn.s.cm-5.m2. Blood pressure and heart rate remained almost unchanged. It is concluded, that Amrinone acts as a positive inotropic and vasodilating drug with the potential for effective treatment in children where conventional therapy has failed.
Wessel
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A
Abteilung Kinderkardiologie und Biomedizinische Technik, Christian-Albrechts-Universität Kiel.
Seiffert
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P
D000293:Adolescent; D000676:Amrinone / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011183:Postoperative Complications / Q000188:drug therapy*; D014655:Vascular Resistance / Q000187:drug effects
D000676:Amrinone
Wirkungen von Amrinon bei Myokardinsuffizienz nach Herzoperationen im Kindesalter.