title: Carcinogenic potential of gasoline and diesel engine oils.
abstract: Used gasoline engine oils are carcinogenic in mouse skin and mutagenic in Salmonella. The toxicity of fresh gasoline engine oils and that of fresh and used diesel engine oils are less well defined. The present studies examined the dermal carcinogenic potential of a series of fresh and used oils from both gasoline and diesel engines. The used oils represented a variety of operating conditions. The objective of the study was to assess the potential carcinogenic hazards associated with exposure to these materials. The majority of the used gasoline engine oils tested were carcinogenic although one oil, collected after a relatively short drainage interval, was inactive in the dermal carcinogenesis bioassay. Additionally, polycyclic aromatic hydrocarbon (PAH) concentrations were elevated in the used oils in comparison to the fresh oils. The fresh gasoline engine oils and both the fresh and used diesel engine oil samples were noncarcinogenic, and there was little evidence of elevated PAH levels in the used diesel engine oils. The carcinogenic potency of used oils from gasoline engines was related to drainage interval, but other factors such as contribution of the fuel due to blowby and driving cycle may also have been important. The used diesel engine oils were not carcinogenic even after extended use.
authors.affiliation: Exxon Biomedical Sciences, Inc., East Millstone, New Jersey 08875-2350.
authors.forename: R H
authors.initials: RH
authors.lastname: McKee
authors.forename: R T
authors.initials: RT
authors.lastname: Plutnick
mesh_terms: D000818:Animals; D002273:Carcinogens; D002849:Chromatography, Gas; D005742:Gasoline; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D010578:Petroleum / Q000633:toxicity*; D011083:Polycyclic Compounds / Q000032:analysis / Q000633:toxicity; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology
chemical_list: D002273:Carcinogens; D005742:Gasoline; D010578:Petroleum; D011083:Polycyclic Compounds