[Effect of ambroxol on surfactant lipids in patients after resection of pulmonary tissue].
Effect of Ambroxol on phospholipids and higher fatty acids of pulmonary surfactant was studied in patients with lung cancer undergoing pulmonary resection. Intravenous administration of Ambroxol was carried out for 8 days in a dose 1000 mg per day before pulmonary resection. It produced elevation of disaturated phosphatidylcholine and the general level of phosphatidylcholine. Also increase of palmitic acid and saturated fatty acids of the phospholipid fraction was found. The results of this study show that Ambroxol on a short time elevates levels of active substances of pulmonary surfactant and decreases the destructive processes of pulmonary parenchyma.
Jabłonka
S
S
Ledwozyw
A
A
Jabłonka
A
A
Jurko
C
C
D000328:Adult; D000368:Aged; D000551:Ambroxol / Q000494:pharmacology*; D001964:Bromhexine / Q000031:analogs & derivatives*; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011663:Pulmonary Surfactants / Q000187:drug effects*
D011663:Pulmonary Surfactants; D000551:Ambroxol; D001964:Bromhexine
Wpływ ambroxolu na lipidy surfaktantu u chorych po wycieciu miazszu płucnego.