Anti-inflammatory studies on Euphorbia prostrata.
Anti-inflammatory studies were conducted in rats on an ethanol extract of whole plant Euphorbia prostrata and its partitioned fractions. The ethyl acetate fraction in an oral dose of 200 mg/kg, inhibited 76% of acute carrageenan-induced paw edema. A fraction, labelled as KSE-23, isolated from the ethyl acetate fraction inhibited 57% of pedal edema at a dose of 8 mg/kg. Acute inflammatory studies of fractions using histamine and bradykinin-induced pedal edema indicated a selective inhibition of histamine-induced edema, suggesting suppression of the first phase of the acute inflammatory reaction.
Singla
A K
AK
Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Pathak
K
K
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001920:Bradykinin; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D006632:Histamine; D008297:Male; D008515:Medicine, Ayurvedic; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D006632:Histamine; D002351:Carrageenan; D001920:Bradykinin