title: Marek's disease virus-induced transient paralysis in chickens: demonstration of vasogenic brain oedema by an immunohistochemical method.
abstract: The presence of vasogenic brain oedema and its distribution in Marek's disease virus (MDV)-induced transient paralysis (TP) were determined in genetically resistant and susceptible inbred White Leghorn chickens. MDV-inoculated TP-susceptible chickens with nervous signs (9 days post-inoculation) had severe vacuolation of cerebellar white matter and associated diffuse leakage of albumin and IgG. The serum protein leakage was associated morphologically with a vasculitis and intramural pseudocyst formation in the walls of blood vessels cuffed by mononuclear cells. This transient vasculitis and resulting vasogenic oedema coincided with the temporary neurological signs seen in TP-susceptible chickens. The vasculitis and vasogenic oedema were not present in brain tissue from recovered MDV-inoculated TP-susceptible chickens, MDV-inoculated TP-resistant chickens, or uninoculated control chickens from either line.
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602.
authors.forename: D E
authors.initials: DE
authors.lastname: Swayne
authors.forename: O J
authors.initials: OJ
authors.lastname: Fletcher
authors.forename: L W
authors.initials: LW
authors.lastname: Schierman
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000473:pathology*; D001929:Brain Edema / Q000150:complications / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology; D002645:Chickens; D007150:Immunohistochemistry; D008380:Marek Disease / Q000150:complications / Q000473:pathology*; D010243:Paralysis / Q000209:etiology / Q000662:veterinary*