title: Conjunctival goblet cell response to vasoconstrictor use.
abstract: Vasoconstrictors such as phenylephrine and naphazoline are used in ophthalmology to decrease hyperemia associated with allergic conjunctivitis and contact lens wear. There is a suspicion, however, that chronic use of these agents can produce dry-eye symptoms in some patients. The purpose of this study was to determine whether vasoconstrictor use interferes with tear film adequacy by decreasing mucin-secreting goblet cells. Cellulose acetate filter strip impressions were taken from the bulbar conjunctiva of rabbit eyes treated with vasoconstrictors or artificial tears for varying periods of time, and the number of goblet cells per light microscopic field counted. There was no significant difference between the number of goblet cells in control and vasoconstrictor-treated animals within each time period. These results indicate that conjunctival goblet cell density is not significantly affected by topical vasoconstrictor use.
authors.affiliation: Weeks Ophthalmology Laboratory, Oregon Health Sciences University, Portland.
authors.forename: S
authors.initials: S
authors.lastname: Shellans
authors.forename: L F
authors.initials: LF
authors.lastname: Rich
authors.forename: I
authors.initials: I
authors.lastname: Louiselle
mesh_terms: D000287:Administration, Topical; D000818:Animals; D003228:Conjunctiva / Q000166:cytology / Q000187:drug effects*; D004848:Epithelium; D007093:Imidazoles / Q000494:pharmacology*; D009093:Mucus / Q000187:drug effects; D009278:Naphazoline / Q000009:adverse effects / Q000494:pharmacology*; D009883:Ophthalmic Solutions / Q000009:adverse effects; D010656:Phenylephrine / Q000009:adverse effects / Q000494:pharmacology*; D011817:Rabbits; D013666:Tears / Q000378:metabolism
chemical_list: D007093:Imidazoles; D009883:Ophthalmic Solutions; D010656:Phenylephrine; D009278:Naphazoline