Novel synthesis of carbocyclic nucleosides from 2-azabicyclo[2.2.1]heptanes via the reductive N2-C3 cleavage reaction as a key step.
Carbocyclic ribofuranosyl and arabinofuranosyl pyrimidine nucleosides were synthesized stereoselectively from 2-azabicyclo[2.2.1]hept-5-en-3-one via NaBH4 promoted C-N bond cleavage reaction as a key step.
Katagiri
N
N
Pharmaceutical Institute, Tohoku University, Sendai, Japan.
Muto
M
M
Kaneko
C
C
D001087:Arabinonucleosides / Q000138:chemical synthesis*; D007769:Lactams; D009705:Nucleosides / Q000138:chemical synthesis*
D001087:Arabinonucleosides; D007769:Lactams; D009705:Nucleosides; C062350:2-azabicyclo(2.2.1)hept-5-en-3-one