[Activity of topical flunoxaprofen in nonspecific vaginitis. Comparison with meclocycline sulfosalicylate].
A trial was performed in 30 patients affected by non-specific vaginitis. The results show that the topical application (by vaginal washings) of flunoxaprofen produces a high therapeutic activity like that of meclocycline. Contrary to meclocycline, flunoxaprofen does not possess bactericidal and bacteriostatic properties. Therefore, the normalization of vaginal flora, with a remarkable increase of Döderlein bacillus, is exclusively due to local antiphlogistic activity of flunoxaprofen. Contrary to meclocycline, flunoxaprofen induces a precocious increase of Döderlein bacillus, necessary for a definitive normalization and to limit the possibility of relapses.
Facchini
V
V
Rispoli
G
G
Dubini
F
F
Bignami
P
P
Sacchi
C
C
D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D001583:Benzoxazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010118:Oxytetracycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014627:Vaginitis / Q000188:drug therapy* / Q000382:microbiology
D000891:Anti-Infective Agents, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001583:Benzoxazoles; C100122:meclocycline; C045356:flunoxaprofen; D010118:Oxytetracycline
Attività di flunoxaprofene per uso topico nelle vaginiti aspecifiche. Confronto con meclociclina solfosalicilato.