title: Determination of the enantiomeric composition of salsolinol in biological samples by high-performance liquid chromatography with electrochemical detection.
abstract: The enantiomers of salsolinol were completely separated as diastereoisomeric derivatives, after reaction with S-1-(1-naphthyl)ethyl isothiocyanate, by reversed-phase high-performance liquid chromatography and quantified by electrochemical detection. Good calibration curves were obtained for the quantification and determination of the enantiomeric composition of salsolinol in human urine. The sensitivity and specificity to the assay also permit the determination of the enantiomeric composition of salsolinol in food such as dried bananas and chocolate.
authors.affiliation: Farmitalia Carlo Erba, Research and Development, Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Pianezzola
authors.forename: V
authors.initials: V
authors.lastname: Bellotti
authors.forename: E
authors.initials: E
authors.lastname: Fontana
authors.forename: E
authors.initials: E
authors.lastname: Moro
authors.forename: J
authors.initials: J
authors.lastname: Gal
authors.forename: D M
authors.initials: DM
authors.lastname: Desai
mesh_terms: D002099:Cacao / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry; D005638:Fruit / Q000032:analysis; D006801:Humans; D007546:Isoquinolines / Q000032:analysis*; D013237:Stereoisomerism
chemical_list: D007546:Isoquinolines; C036617:salsolinol