[Effect of anesthesia with sodium pentobarbital on the contractile response of the rat aorta].
Experiments were performed in isolated aortic rings from rats anesthetized with sodium pentobarbital ("P") or sacrificed by cervical traumatism ("T"). The response of both aortic rings ("P" and "T") was compared after K depolarizing solution (35, 50 and 100 mM) and after noradrenaline (10(-6)M. Neither the response to the different concentrations of K nor to the alpha agonist effect of NOR was significantly different in rats "P" or "T". The effect of NOR in rats "P" or "T" was not different either in the rapid or slow phase of contraction. The pentobarbital added to the bath, however, depressed the contractile response to either K+ or NOR. This depression, however, was reversible after the rinse of the preparation. We conclude that in spite of the depression produced by the sodium pentobarbital to the contractile response of aorta rings, this depression is reversible and disappeared after the usual period of stabilization. The effect then cannot explain differences in results in reports in which the animals were previously anesthetized or not.
Seade
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Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Argentina.
Grand
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Cingolani
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HE
D000818:Animals; D001011:Aorta; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010424:Pentobarbital; D011188:Potassium; D009638:Norepinephrine
Acción de la anestesia con pentobarbital sobre la respuesta contráctil de la aorta de rata.