title: Majorenolide and majorynolide: a new pair of cytotoxic and pesticidal alkene-alkyne delta-lactones from Persea major.
abstract: From the EtOH extract of the bark of Persea major, two bioactive compounds, majorynolide [1] and majorenolide [2], were isolated by activity-directed fractionation using brine shrimp. Their structures have been elucidated on the basis of spectral data as a pair of new alkene-alkyne delta-lactones, each with an exocyclic alkylidene methine carbon. Both 1 and 2 are moderately cytotoxic, and 2 is selectively pesticidal.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
authors.forename: W W
authors.initials: WW
authors.lastname: Ma
authors.forename: J E
authors.initials: JE
authors.lastname: Anderson
authors.forename: C J
authors.initials: CJ
authors.lastname: Chang
authors.forename: D L
authors.initials: DL
authors.lastname: Smith
authors.forename: J L
authors.initials: JL
authors.lastname: McLaughlin
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D001156:Artemia / Q000187:drug effects; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010575:Pesticides / Q000302:isolation & purification*; D010944:Plants / Q000032:analysis*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D010575:Pesticides; C062900:majorynolide; C062899:majorenolide