[The development of osteoarthrosis and the role of collagen in the pathophysiology of its development].
The work deals with the structure, chemical composition and physical properties of individual types of collagen of which thirteen has been so far described. Special attention is devoted to the types of collagen II, VI, IX and XI which are found in the articular hyaline cartilage. The main collagen type of the articular cartilage is type II which makes up approximately 90 per cent of all the collagen. The remaining three types fall into the so called minority types. Collagen of type IX differs from other types by the kink in its structure. This type of collagen represents a certain transition to proteoglycans with regard to the fact that the lateral glycoaminoglycan chain is attached. The work is supplemented with electron microscope pictures of individual molecules of these types. It describes also individual stages of biosynthesis and special attention is devoted to the aggregation of molecules into fibrils. The authors describe the cross-linking elements of lysinonorleucine and pyridinoline type. The changes which occurring in the structure and metabolism of collagen in the course of osteoarthrosis are described. The role of adhesive proteins is mentioned and the influence of the osteoarthrotic changes on nutrition and its function as well as on the development of pathogenetic mechanism is described.
Adam
M
M
Hulejová
H
H
Miterová
S
S
D003094:Collagen / Q000378:metabolism*; D006801:Humans; D010003:Osteoarthritis / Q000378:metabolism*
D003094:Collagen
Vznik osteoartrózy a úloha kolagenu v patofyziologii jejího vzniku.