[The significance of an increased protein and fat content in the food ration of rats for the development of stable alloxan diabetes].
An effective model of stable and prolonged alloxan diabetes in rats was described. For this purpose the rats were kept on a synthetic diet with the increased level of proteins and lipids during 1-2 mos. before i.v. injection of alloxan at a dose of 35-40 mg/kg with subsequent feeding by this ration during all the time of the experiment. This model of experimental diabetes ensures a high level of hyperglycemia and hypoinsulinemia as well as a high titer of activity of the diabetogenic factor, to the same extent, as in rats kept on the common laboratory ration.
Ul'ianov
A M
AM
Tarasov
Iu A
IuA
D000496:Alloxan / Q000633:toxicity; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000209:etiology* / Q000401:mortality; D004041:Dietary Fats / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D004195:Disease Models, Animal; D007330:Insulin Antibodies / Q000032:analysis; D008297:Male; D010907:Pituitary Hormones / Q000097:blood; D051381:Rats; D013997:Time Factors
D001786:Blood Glucose; C488867:DGF protein, rat; D004041:Dietary Fats; D004044:Dietary Proteins; D007330:Insulin Antibodies; D010907:Pituitary Hormones; D000496:Alloxan
Znachenie povyshennogo soderzhaniia belkov i zhirov v pishchevom ratsione krys dlia razvitiia ustoĭchivogo alloksanovogo diabeta.