[Endogenous ethanol in the blood and tissues of rats with hypobaric hypoxia].
Albino male rats weighing 160-180 g were used to study the effect of short-term hypobaric hypoxia (ascent in an altitude chamber to 2500 m and 5000 m for 1 hr) on endogenous ethanol measured in blood, brain and liver; simultaneously enzymes responsible for ethanol and acetaldehyde metabolism were determined. Endogenous ethanol in blood and tissues was found to be a very sensitive marker of hypoxia which was not correlated with lactate, pyruvate, lipid peroxidation or 11-hydroxycorticosteroids. The latter parameters varied in response to severe hypoxia.
Tarasov
Iu A
IuA
Ostrovskiĭ
Iu M
IuM
Satanovskaia
V I
VI
Liopo
A V
AV
Velichko
M G
MG
Abakumov
G Z
GZ
D000079:Acetaldehyde / Q000378:metabolism; D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000818:Animals; D001273:Atmosphere Exposure Chambers; D001921:Brain / Q000378:metabolism*; D000431:Ethanol / Q000097:blood / Q000378:metabolism*; D000860:Hypoxia / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D010100:Oxygen / Q000008:administration & dosage*; D051381:Rats
D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde; D010100:Oxygen
Endogennyĭ étanol krovi i tkaneĭ krys pri gipobaricheskoĭ gipoksii.