Gastrointestinal blood flow and oxygen delivery during environmental cold stress: effect of anaemia.
We studied the effect of environmental cold stress with and without isovolaemic anaemia on blood flow and oxygen delivery to the stomach, small intestine, and colon. The purpose of the study was to investigate the independent and combined effects of an increased oxygen demand (cold stress) and decreased oxygen availability (anaemia). Six, 3-4 days-old, awake piglets having normal haematocrit (26%), were studied in a warm environment (31.7 +/- 0.4 degrees C) and 30 min after reaching the nadir of cold stress (19.9 +/- 0.4 degrees C). Subsequently, a warm environment was reestablished and a partial volume, plasma exchange transfusion was done to lower the haematocrit to approximately 15%. Piglets were then studied as before in warm (32 +/- 0.5 degrees C) and cold (19.3 +/- 0.3 degrees C) environments. In the non-anaemic study phase, cold stress provoked a decrease in blood flow (ml.100g-1.min-1) to the small intestine (226 +/- 22 vs. 134 +/- 22) while oxygen delivery (ml O2.100g-1.min-1) was decreased to the stomach (13.6 +/- 1.4 vs 9.3 +/- 1.7), small intestine (19.6 +/- 0.6 vs. 11.2 +/- 1.1) and colon (9.6 +/- 1.7 vs. 6.1 +/- 1.0). Following plasma exchange transfusion (anaemic study phase), warm environment values for gastrointestinal blood flow did not differ from non-anaemic warm environment values. However, mean oxygen delivery while in a warm environment was decreased to the stomach (-45%), small intestine (-49%) and colon (-42%). Among anaemic piglets, cold stress provoked a further decrease in oxygen delivery to the small intestine (9.9 +/- 1.2 vs. 6.5 +/- 0.9).(ABSTRACT TRUNCATED AT 250 WORDS)
Mayfield
S R
SR
Brown University Program in Medicine, Department of Pediatrics, Women and Infants Hospital of Rhode Island 02908.
Shaul
P W
PW
Oh
W
W
Stonestreet
B S
BS
D000740:Anemia / Q000097:blood / Q000503:physiopathology*; D000818:Animals; D000831:Animals, Newborn; D001784:Blood Gas Analysis; D001794:Blood Pressure; D003080:Cold Temperature / Q000009:adverse effects*; D003106:Colon / Q000098:blood supply; D004064:Digestive System / Q000098:blood supply*; D006339:Heart Rate; D007421:Intestine, Small / Q000098:blood supply; D010101:Oxygen Consumption; D012039:Regional Blood Flow; D013270:Stomach / Q000098:blood supply; D013552:Swine