The synthetic DNA duplex of poly d(Abr5U).poly d(Abr5U) adopts an A-DNA-like structure.
An X-ray fiber diffraction study of the synthetic DNA duplex poly d(Abr5U).poly d(Abr5U) shows that its sodium salt adopts an unexceptional A-DNA-like structure. Similar to A-DNA, two molecules are packed in a monoclinic unit cell (a = 2.23 nm, b = 4.14 nm, c = 5.61 nm and alpha = beta = gamma = 90 degrees) of space group C2. Because of its dinucleotide chemical motif, the c-repeat is twice that in A-DNA but, notably, corresponding backbone conformation angles of adjacent nucleotides are almost identical. This is in marked contrast to many B-like conformations of polydinucleotides.
Chandrasekaran
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R
Whistler Center for Carbohydrate Research, Purdue University, West Lafayette, Indiana 47907.
Puigjaner
L C
LC
Arnott
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S
He
R G
RG
Brahms
S
S
Brahms
J
J
D003460:Crystallization; D004247:DNA; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011089:Polydeoxyribonucleotides; D014961:X-Ray Diffraction
D011089:Polydeoxyribonucleotides; C062990:polyd(Abr5U).polyd(Abr5U); D004247:DNA