Virus-associated hemophagocytic syndrome: the diagnostic usefulness of immature histiocytes with benign features in the bone marrow.
A 2-year-old girl developed fever, hepatosplenomegaly, jaundice, lymphadenopathy and pancytopenia. Bone marrow examination revealed increased immature histiocytes (5.5%) and mature histiocytes with hemophagocytosis. All the abnormalities were normalized in one month without any chemotherapy. It was suggested that the presence of immature histiocytes with benign features, even if their number exceeds that of mature histiocytes, does not favor the diagnosis of malignant histiocytosis.
Hara
T
T
Mizuno
Y
Y
Ueda
K
K
Suda
M
M
D001853:Bone Marrow / Q000473:pathology*; D002675:Child, Preschool; D005260:Female; D006644:Histiocytes / Q000473:pathology*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000473:pathology*; D006801:Humans; D014777:Virus Diseases / Q000473:pathology*