[Selective inducing ability of DL-111-1T towards mixed function oxidase in female rat liver and human amnion fluid cell].
Following pretreatment of adult female rats with contragestational agent 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazol (DL 111-1T) 20 mg/kg.d for 2 consecutive days, the hepatic microsomal MFO and UDPGT activities were induced to a constant level, being characteristic of arylhydrocarbon type of induction. Coincubation of human amnion FL cell with 0.1 mumol/L of DL-111-1T for 24 h produced a 4.5-fold induction of AHH activity of the cell. This inducing ability was 3 times that of PB, but 1/2 that of 3-MC. According to these observations, DL-111-1T may also be considered as a polycyclic arylhydrocarbon type inducer toward human amnion FL cell's MFO which contains mainly of cytochrome P-448. UDS test showed that DL-111-1T itself could not induce UDS of FL cell.
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D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D000650:Amnion / Q000166:cytology; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005260:Female; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014230:Triazoles / Q000494:pharmacology*
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D014230:Triazoles; C030266:3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases