[PGE and PGF2-alpha levels in the umbilical cord vessels. Relationship to acid-base equilibrium in the umbilical artery].
To asses the possible role of prostaglandins in the fetoplacental circulation during delivery PGE and PGF2-alfa plasma levels were measured in the umbilical vessels of term newborns. The levels of PGF2-alfa in blood from the umbilical vein are significantly higher and more variable than in the umbilical artery; 83.38 +/- 78.05 pg/ml versus 43.28 +/- 5.32 pg/ml. PGE levels are also higher in the vein 114.73 +/- 25.16 pg/ml than in the artery 83.63 +/- 9.22 pg/ml. There was a statistically significant negative correlation between the arterial pH and PGE in the umbilical vein these results support the idea that the plasmatic umbilical prostaglandins are synthetized by the placenta the variability in the values obtained in venous umbilical blood may reflect the different times of ligation of the umbilical cord. A decrease in fetal pH may be the stimulus for the prostaglandin synthesis by the placenta.
del Moral García
T
T
Hospital Clinico Universitario San Cecilio, Granada.
Loscertales Abril
M
M
Ruiz Extremera
A
A
Martínez Sampere
J J
JJ
Miras Baldo
M J
MJ
López Muñoz
J
J
Molina Font
J A
JA
D000136:Acid-Base Equilibrium; D001034:Apgar Score; D015237:Dinoprost / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011458:Prostaglandins E / Q000097:blood*; D014469:Umbilical Arteries / Q000032:analysis*; D014470:Umbilical Cord / Q000098:blood supply*
D011458:Prostaglandins E; D015237:Dinoprost
Niveles de PGE y PGF2-alfa en los vasos del cordón umbilical. Su relación con el equilibrio ácido-base de la arteria umbilical.