title: Flunarizine does not delay the development of generalized seizures by amygdala kindling.
abstract: Adult rats underwent amygdala kindling after the administration of vehicle, flunarizine 20 mg/kg/day, or flunarizine 40 mg/kg/day. Stimuli were delivered thrice daily at current intensities twice after-discharge threshold (ADT). Flunarizine did not alter initial or post-kindling ADT and did not affect the latency (number of stimuli) to the first stage 5 seizure. Apart from a tendency to increase the latency between the first and the 4th stage 5 seizures, flunarizine had little if any effect on amygdala kindling in this protocol.
authors.affiliation: Department of Pediatrics, Evanston Hospital, IL 60201.
authors.forename: B L
authors.initials: BL
authors.lastname: Trommer
authors.forename: J F
authors.initials: JF
authors.lastname: Pasternak
mesh_terms: D000679:Amygdala; D000818:Animals; D005444:Flunarizine / Q000627:therapeutic use*; D007696:Kindling, Neurologic / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000188:drug therapy*
chemical_list: D005444:Flunarizine