title: The hepatic lipid peroxidation, copper and fibrosis in cholestatic rats.
abstract: Hepatic lipid peroxidation was shown to be stimulated in the livers of cholestatic rats with increased hydroxyproline levels. In another group, cholestatic rats were fed with a copper-supplemented diet to increase hepatic copper levels. Although liver copper concentrations increased about 16-fold in copper supplemented cholestatic rats compared to normally fed cholestatic rats, no change was observed either in hepatic lipid peroxidation or in hydroxyproline levels.
authors.affiliation: Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Aykac
authors.forename: G
authors.initials: G
authors.lastname: Ozdemirler
authors.forename: N
authors.initials: N
authors.lastname: Alptekin
authors.forename: N
authors.initials: N
authors.lastname: Arican
authors.forename: B
authors.initials: B
authors.lastname: Oz
authors.forename: M
authors.initials: M
authors.lastname: Uysal
authors.forename: H
authors.initials: H
authors.lastname: Oz
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D002780:Cholestasis, Intrahepatic / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D003300:Copper / Q000378:metabolism*; D004032:Diet; D004195:Disease Models, Animal; D006909:Hydroxyproline / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D008099:Liver / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000209:etiology* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001647:Bile Acids and Salts; D003300:Copper; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin; D006909:Hydroxyproline