[Ways to optimize the cerebral circulation during extreme actions on the brain].
The effect of mildronate (25 mg/kg, i.v.) administration during 14 days on the restoration of cerebral blood flow and vascular reactivity after local lesions and ischemia, was studied in rabbits. The effect involved an improvement of restorative processes due to a faster normalizing of reactivity of cerebral vessels. The latter seems to be more important for optimization of cerebral blood flow after extreme effects than the absolute level of the cerebral blood flow.
Gaĭdar
B V
BV
Parfenov
V E
VE
Vaĭnshteĭn
G B
GB
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology*; D002545:Brain Ischemia / Q000503:physiopathology; D002339:Carotid Arteries / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D004567:Electrodes, Implanted; D008026:Ligation; D008763:Methylhydrazines / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors
D008763:Methylhydrazines; C050147:3-(2,2,2-trimethylhydrazine)propionate
Puti optimizatsii mozgovogo krovoobrashcheniia pri ékstremal'nykh vozdeĭstviiakh na golovnoĭ mozg.