Circulating immune complexes in sickle cell anaemia.
A polyethylene-glycol insoluble serum fraction was studied in patients with sickle cell anaemia during the steady state of the disease. The levels of C1q-precipitins were normal but increased amounts of proteins, IgM C3 and factor B were detected in this immune complex enriched serum fraction. These findings are a sign that circulating immune complexes can be detected even in the asymptomatic period of the disease.
Donadi
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EA
Department of Clinical Medicine, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
Carvalho
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IF
Falcão
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RP
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis; D002648:Child; D015922:Complement C1q / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D011234:Precipitins / Q000032:analysis
D000936:Antigen-Antibody Complex; D001798:Blood Proteins; D007136:Immunoglobulins; D011234:Precipitins; D015922:Complement C1q