Respiratory mechanics in the normal dog determined by expiratory flow interruption.
We recently proposed an eight-parameter model of the respiratory system to account for its mechanical behavior when flow is interrupted during passive expiration. The model consists of two four-parameter submodels representing the lungs and the chest wall, respectively. The lung submodel consists of an airways resistance together with elements embodying the viscoelastic properties of the lung tissues. The chest wall submodel has similar structure. We estimated the parameters of the model from data obtained in four normal, anesthetized, paralyzed, tracheostomized mongrel dogs. This model explains why lung tissue and chest wall resistances should be markedly frequency dependent at low frequencies and also permits a physiological interpretation of resistance measurements provided by the flow interruption method.
Bates
J H
JH
Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
Brown
K A
KA
Kochi
T
T
D000403:Airway Resistance / Q000502:physiology*; D000818:Animals; D004285:Dogs; D008954:Models, Biological; D012123:Pulmonary Ventilation / Q000502:physiology*