[Suppression of the neuroeffector transmission of the sympathetic system].
A geometrical model of inhibition of neuroeffector transmission of the sympathetic system was constructed on the basis of the polymetric method of registration of a complex of somatovegetative indices and multiparametric description of the effect of alpha- and beta-adrenergic blocking agents and adrenomimetic drugs in experiments on intact rats. Similar multiparametric description of the effect of therapeutic doses of adrenergic blocking agents on patients with hypertension was conducted in the clinic. The results obtained in the clinic were interpreted on the basis of the experimental models. The authors show the possibilities of the polymetric method in more scrupulous study of the functional condition of the various links of the vegetative nervous system and in a stricter individual approach to treatment with adrenergic agents.
Dmitrieva
N V
NV
Farber
M F
MF
Podzolkov
V I
VI
Starovoĭtova
S P
SP
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008959:Models, Neurological; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D009451:Neuroeffector Junction / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D013566:Sympathomimetics / Q000494:pharmacology / Q000627:therapeutic use
D011941:Receptors, Adrenergic; D013566:Sympathomimetics
Issledovanie ugneteniia neĭroéffektornoĭ peredachi simpaticheskoĭ sistemy.