Trisomy 7 and sex chromosome loss in human brain tissue.
Short-term cultures of nonneoplastic brain tissue from 11 patients, seven of whom had a malignant brain tumor, were cytogenetically examined. In only a single case was a wholly normal chromosome complement detected; the remaining ten cases exhibited mosaicism with clonal numerical aberrations found alongside cells carrying a normal karyotype. The abnormal clones were characterized by trisomy 7, the loss of the Y chromosome in men and an X chromosome in women, or by combinations thereof. No structural aberrations were present. Our findings demonstrate that although -Y, -X, and +7 have in the past repeatedly been associated with brain tumors, these changes presumably reflect normal in vivo organ mosaicism and, thus, should not be accepted as neoplasia-specific in this context.
Heim
S
S
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Mandahl
N
N
Jin
Y
Y
Strömblad
S
S
Lindström
E
E
Salford
L G
LG
Mitelman
F
F
D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology / Q000648:ultrastructure*; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology / Q000648:ultrastructure; D002455:Cell Division; D002869:Chromosome Aberrations / Q000235:genetics; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7 / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D012730:Sex Chromosomes; D014314:Trisomy