Muscular fibrosis due to chronic intramuscular administration of narcotic analgesics.
Chronic intramuscular injections, particularly of narcotic analgesics, are an uncommon cause of myopathy. We report two patients with pentazocine- and meperidine-related myopathy. Narcotic-induced muscular fibrosis and contractures must be considered in patients with a pattern of muscle involvement that does not conform to any recognized myopathy, but allows for self-administration of injections. Trauma due to needle puncture, repetitive infections and a local myotoxic effect of the drugs probably contribute to these lesions.
von Kemp
K
K
Herregodts
P
P
Duynslaeger
L
L
Deleu
D
D
Bruyland
M
M
Cham
B
B
D000328:Adult; D005355:Fibrosis; D006801:Humans; D007273:Injections, Intramuscular / Q000009:adverse effects*; D008297:Male; D008614:Meperidine / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*; D009133:Muscular Atrophy / Q000209:etiology / Q000473:pathology
D008614:Meperidine