Linkage relations of the locus for granular corneal dystrophy Groenouw type I with 35 polymorphic systems.
The paper presents preliminary results of linkage relations of the locus for granular corneal dystrophy Groenouw type I employing 35 classic genetic markers. Blood and saliva from 124 members of one family with this disorder were examined with the aim of localizing the disease to a certain chromosome. The highest lodscore was 1.04 in females at theta 0.00 to the system C1R, thus supplying a clue for continued gene-mapping investigations on the short arm of chromosome No. 12.
Møller
H U
HU
Department of Ophthalmology, Aarhus University Hospital, Copenhagen.
Eiberg
H
H
Kruse
T A
TA
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002881:Chromosomes, Human, Pair 12; D003317:Corneal Dystrophies, Hereditary / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*