Platelet intracellular pH in essential hypertensives and normotensives.
Using the intracellularly trapped pH-sensitive fluorescent dye, BCECF, basal intracellular pH was measured in 18 essential hypertensives and 23 normotensives. The average intracellular pH was slightly, but not significantly, lower in the hypertensives (7.173 +/- 0.017 versus 7.211 +/- 0.014, P = 0.09). Although basal intracellular pH is not significantly altered in hypertension, abnormal regulation of intracellular pH during growth factor or agonist stimulation may play a role in the development or maintenance of hypertension.
Weder
A B
AB
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0500.
Bahadosingh
S E
SE
Neagos
G R
GR
D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D005260:Female; D005452:Fluoresceins; D005456:Fluorescent Dyes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000097:blood*; D008297:Male; D008722:Methods
D005452:Fluoresceins; D005456:Fluorescent Dyes; C043829:2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein