title: Plasma kallikrein clearance by the liver of normal and injured rats.
abstract: We report the clearance of rat plasma kallikrein (RPK) by the perfused livers of normal rats and from others at 2 and 4 days after subcutaneous injection of turpentine oil. RPK removal from the perfusate follows a logarithmic curve (y = a+b lnx) and from this equation its half-life of removal can be calculated. RPK clearance rate followed the potential equation y = axb. Both the half-life of RPK removal and RPK clearance rates were similar in the 3 groups of perfused livers. We conclude that, at the initial concentration of RPK used (approximately 3 nM), its liver clearance is not affected during the acute-phase response to inflammation.
authors.affiliation: Department of Medicine, Escola Paulista de Medicina, São Paulo, Brasil.
authors.forename: C F
authors.initials: CF
authors.lastname: Toledo
authors.forename: M
authors.initials: M
authors.lastname: Kouyoumdjian
authors.forename: D R
authors.initials: DR
authors.lastname: Borges
mesh_terms: D000818:Animals; D006207:Half-Life; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology*; D007610:Kallikreins / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D051381:Rats; D012016:Reference Values; D014425:Turpentine
chemical_list: D007610:Kallikreins; D014425:Turpentine