Hypoglycaemic activity of carbothioamides and related 1,2,4-thiodiazolidines.
N-[imino(ethyl ethylidine hydrazine)methyl]-N-aryl-2- amino-carbothioamidine hydrochlorides with ethylmethylketothiosemicarbazone in acetone medium at 0-5 degrees C. The carbothioamides were oxidized by H2O2 to 1,2,4-thiodiazolidine derivatives. The 4-Cl derivative in both the series was the most active hypoglycaemic agent. The compounds lowered mean blood sugar levels (MBSL) by 38.81% (compound 2, Table II) and 15.19% (compound 2, Table III) respectively after 24 hours of drug treatment. The compounds also showed antidiabetic activity in alloxan diabetic rats.
Chaubey
M
M
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India.
Pandeya
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D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D005260:Female; D007004:Hypoglycemic Agents / Q000138:chemical synthesis*; D008297:Male; D051381:Rats; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013830:Thiadiazoles; D013882:Thiosemicarbazones