Frequent relapser minimal change nephrosis: an unrecognized X-linked disorder?
We report three brothers who developed nephrosis between the age of 3-10 years. The parents were nonconsanguineous and of Arab descent. The mother's sister had a son with a similar condition. Patients were steroid responders and frequent relapsers. Renal biopsies in the three brothers showed findings of minimal change nephrosis. This family may suggest the existence of an X-linked recessive nephrosis which provides further evidence for genetic heterogeneity of familial nephrosis.
Awadalla
N B
NB
Department of Paediatrics, Amiri Hospital and Faculty of Medicine, Raas, Kuwait.
Teebi
A S
AS
Elzouki
A Y
AY
Shaltout
A
A
D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003241:Consanguinity; D006801:Humans; D007730:Kuwait; D008297:Male; D009402:Nephrosis, Lipoid / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D012008:Recurrence
D011239:Prednisolone