Studies on the panaxytriol of Panax ginseng C. A. Meyer. Isolation, determination and antitumor activity.
An antitumor-active substance was obtained from the residue of the ethyl acetate extract of red ginseng, a traditional Chinese medicine, by chromatography on a silica gel column. From the proton and carbon-13 nuclear magnetic resonance spectra, it was identified as heptadeca-1-ene-4,6-diyne-3,9,10-triol (panaxytriol). The panaxytriol contents of red ginseng and white ginseng, determined by gas chromatography after solvent extraction and formation of trimethylsilyl derivatives, were 0.38 and 0.25 mg/g, respectively. Panaxytriol showed a growth-inhibitory activity against several tumor cell lines.
Matsunaga
H
H
Katano
M
M
Yamamoto
H
H
Mori
M
M
Takata
K
K
D000480:Alkynes; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D053281:Enediynes; D005233:Fatty Alcohols / Q000302:isolation & purification / Q000494:pharmacology*; D005894:Panax / Q000032:analysis*; D010946:Plants, Medicinal; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000480:Alkynes; D000972:Antineoplastic Agents, Phytogenic; D053281:Enediynes; D005233:Fatty Alcohols; C057682:panaxytriol