title: The sennoside constituents of rhei rhizoma and sennae folium as inhibitors of serum monoamine oxidase.
abstract: Four (in total) compounds with inhibitory effects on the activity of bovine serum monoamine oxidase were isolated from the methanol-water extracts of Rhei Rhizoma (Daiou) and Sennae Folium (Senna), and identified as sennosides A, B, E and F. Among them, sennosides A and B were obtained from both Rhei Rhizoma and Sennae Folium, while sennosides E and F were detected only in the former. The 50% inhibitory concentrations of the four sennosides were 17, 9, 24 and 13 microM, respectively, and the type of inhibition by seenosides A and B with respect to allylamine as the substrate was non-competitive.
authors.forename: A
authors.initials: A
authors.lastname: Hiraoka
authors.forename: S
authors.initials: S
authors.lastname: Koike
authors.forename: S
authors.initials: S
authors.lastname: Sakaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Masuda
authors.forename: F
authors.initials: F
authors.lastname: Terai
authors.forename: I
authors.initials: I
authors.lastname: Miura
authors.forename: T
authors.initials: T
authors.lastname: Kawasaki
authors.forename: H
authors.initials: H
authors.lastname: Kawai
authors.forename: M
authors.initials: M
authors.lastname: Sakakibara
mesh_terms: D000880:Anthraquinones / Q000032:analysis / Q000494:pharmacology*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000032:analysis*; D012676:Senna Extract; D000081226:Sennosides
chemical_list: D000880:Anthraquinones; D008996:Monoamine Oxidase Inhibitors; D000081226:Sennosides; D012676:Senna Extract