[A study of the effect of radiation on megakaryocytopoiesis using a mathematical model].
Mathematical modelling used in analysing the postirradiation changes in megakaryocytopoiesis permitted to determine the level of radiation-induced injury in each experiment conducted and to show that megakaryocytopoiesis regulation followed the same mechanism after irradiation as it does normally and after the effect of hydroxyurea and anti-thrombocyte serum. The analysis has demonstrated that after the stem cell death induced by ionizing radiation, the regeneration can be provided by the committed cells, and the level of regeneration is determined by the maturity of precursors.
Selivanov
V A
VA
Akhmadieva
A Kh
AKh
Lanin
V N
VN
Tiazhelova
V G
VG
D000818:Animals; D005720:Gamma Rays; D006410:Hematopoiesis / Q000528:radiation effects*; D008433:Mathematics; D008533:Megakaryocytes / Q000502:physiology*; D051379:Mice; D008954:Models, Biological
Issledovanie deĭstviia radiatsii na megakariotsitopoéz s pomoshch'iu matematicheskoĭ modeli.