Condensed thienopyrimidines. IV. Synthesis and gastric antisecretory activity of 2,3-dihydro-5H-oxazolothienopyrimidine derivatives.
2,3-Dihydro-5H-oxazolo[3,2-a]thieno[3,2-d]-(2a--d), [3,4-d]-(2e--h), and [2,3-d]pyrimidine derivatives (2i,j) were synthesized and evaluated for gastric antisecretory activity. These analogues (2) were prepared stepwise starting from formylthiophenecarbamates (4). The structure-activity relationships of these compounds are discussed.
Sugiyama
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M
Sakamoto
T
T
Tabata
K
K
Fukumi
H
H
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000897:Anti-Ulcer Agents; D010080:Oxazoles; D011743:Pyrimidines; D013876:Thiophenes