The effect of topically applied corticosteroids and zinc on the metallothionein content of skin in an experimental model.
The metallothionein (MT) content in hairless mouse skin was determined after topical application of various glucocorticoids or zinc oxide (ZnO). Dexamethasone (1%) in a cream base or zinc paste (20% zinc oxide) were applied twice daily, at a dose of 0.5 g, to the dorsal surface of the mouse. These experiments were conducted for 7 days. The MT content of the skin increased in a time-dependent manner after dexamethasone application with maximal values (7.1 +/- 0.29 pmol MT/mg wet weight) seen after 5 days, whereas zinc paste caused only slight increases after 3 days of treatment. The effect of hydrocortisone and triamcinolone-acetonide on the MT content of the skin was also studied. The physiological significance of these results is briefly discussed.
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D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D006854:Hydrocortisone; D008668:Metallothionein / Q000032:analysis*; D051379:Mice; D008812:Mice, Hairless; D012867:Skin / Q000032:analysis*; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D008668:Metallothionein; D014222:Triamcinolone Acetonide; D015032:Zinc; D006854:Hydrocortisone