Fibronectin in reproduction.
The fibronectin (FN) levels in human follicular fluids have been shown to correlate well with follicular size and oocyte maturity, suggesting a role of FN in oocyte maturation. When added to the culture medium, the synthetic peptide Gly-Arg-Gly-Asp-Ser (GRGDS), which specifically inhibits the cell-binding of FN, has been shown to inhibit both spontaneous resumption of meiosis and gonadotropin-releasing hormone-induced meiosis of the oocytes. In another set of experiments, GRGDS has been found to inhibit the in vitro cleavage of mouse embryos by a still unknown mechanism.
Hung
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Department of Obstetrics & Gynecology, University of Miami School of Medicine, FL 33101.
Tsuiki
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Yemini
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D000818:Animals; D005314:Embryonic and Fetal Development / Q000502:physiology; D005260:Female; D005353:Fibronectins / Q000032:analysis / Q000502:physiology*; D015571:Follicular Fluid / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D009865:Oocytes / Q000502:physiology; D006080:Ovarian Follicle / Q000502:physiology; D012098:Reproduction / Q000502:physiology*
D005353:Fibronectins