[Psychotropic effects of glutamic acid diethyl ester in mice].
In 1 hour after intraperitoneal injection glutamic acid diethyl ester (GED) in doses 200 and 500 mg/kg decreased locomotor activity and exploratory patterns of mice in "open field" test. GED in doses 100 and 200 mg/kg diminished the immobilization period of animals in forced swimming test, that proves the reversal interaction of glutamatergic and catecholaminergic systems in CNS. Glutamate receptors antagonist--GED in doses 100-200 mg/kg disrupted passive avoidance reaction at 30 min before acquisition and retrieval, therefore glutamate receptors are involved into fixation and retrieval of memory engram.
Kovalev
G V
GV
Sazhin
V A
VA
Ianitskaia
A V
AV
D000647:Amnesia / Q000139:chemically induced; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D005971:Glutamates / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011619:Psychotropic Drugs / Q000494:pharmacology*
D005971:Glutamates; D011619:Psychotropic Drugs; C011829:glutamic acid diethyl ester
Izuchenie psikhotropnykh éffektov diétilovogo éfira glutaminovoĭ kisloty u mysheĭ.