[Studies of the active constituents of the Chinese drug "duhuo" Angelica pubescents].
Eight coumarins isolated from the alcohol extract of the Chinese drug "Duhuo", the root of Angelica pubescents Maxim. f. biserrata Shan et Yuan (Umbelliferae) were elucidated to be columbianetin (I), columbianetin acetate (II), columbiadin (III), osthol (IV), isoimperatorin (V), bergapten (VI), xanthotoxin (VII), and columbianetin-beta-D-glucopyranoside (VIII), by chemical and spectral analysis, compound VIII was isolated from plant for the first time. All these coumarins were tested on platelet aggregation induced by 2 microns ADP. I, II, III, IV and VIII showed strong inhibiting activity against platelet aggregation.
Li
R Z
RZ
He
Y Q
YQ
Chiao
M
M
Xu
Y
Y
Zhang
Q B
QB
Meng
J R
JR
Gu
Y
Y
Ge
L P
LP
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D011564:Furocoumarins / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats
D004365:Drugs, Chinese Herbal; D011564:Furocoumarins; D005960:Glucosides; D006027:Glycosides; D010975:Platelet Aggregation Inhibitors; C062747:columbianetin glucopyranoside