Effects of maternal ethanol ingestion on the uptake of alpha-aminoisobutyric acid by fetal rat liver, lung and brain.
Maternal ethanol ingestion reduced the uptake of [14C]-alpha-aminoisobutyric acid (AIB) by placenta and fetal liver, lung and brain when compared with pair-fed or ad libitum-fed controls. The ratios between fetal tissue and plasma radioactivities indicated reduced AIB transport into the tissues of the ethanol-fed fetuses. Organ weights correlated with the fetal:maternal plasma 14C ratio, an indicator of the rate of placental AIB transfer, and with the tissue AIB uptake. These observations suggest that ethanol-induced growth retardation may reflect reduced nutrient availability resulting from impaired transport processes.
Snyder
A K
AK
Veterans Administration Medical Center, North Chicago, Ill.
Singh
S P
SP
Pullen
G L
GL
Eman
S
S
D000621:Aminoisobutyric Acids / Q000493:pharmacokinetics*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005317:Fetal Growth Retardation / Q000188:drug therapy; D005333:Fetus / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D009928:Organ Specificity; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D000621:Aminoisobutyric Acids; C100049:2-aminoisobutyric acid; D000431:Ethanol