title: Oxypurinol attenuates ischemia-induced hippocampal damage in the gerbil.
abstract: Oxypurinol, an inhibitor of the enzyme xanthine oxidase, reduced ischemic hippocampal damage and the associated hypermotility in Mongolian gerbils. Cerebral ischemia was induced in unanesthetized gerbils by a bilateral 5-min occlusion of the carotid arteries. Oxypurinol (40 mg/kg, IP), administered 20 min prior to carotid occlusion, prevented the increase in locomotor activity observed in saline-injected ischemic animals and significantly reduced the damage to, and loss of, CA1 hippocampal neurons observed 5 days postischemia. These findings suggest that oxypurinol may be useful for the prevention of cerebral ischemic damage.
authors.affiliation: Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201.
authors.forename: J W
authors.initials: JW
authors.lastname: Phillis
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D008297:Male; D010117:Oxypurinol / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D014969:Xanthine Oxidase / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D011743:Pyrimidines; D014969:Xanthine Oxidase; D010117:Oxypurinol