O-alkyl O-nucleoside 3'-phosphonates as novel starting materials for oligonucleotide synthesis.
It was found that the title compounds were activated rapidly into the corresponding highly reactive phosphorochloridites by use of tris(2,4,6-tribromophenoxy)dichloro-phosphorane (BDCP) as a chlorinating reagent. The reaction was applied to the synthesis of oligodeoxyribonucleotides.
Wada
T
T
Department of Life Chemistry, Tokyo Institute of Technology, Yokohama, Japan.
Kato
R
R
Hotoda
H
H
Sekine
M
M
Hata
T
T
D007202:Indicators and Reagents; D009705:Nucleosides; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D063065:Organophosphonates; D009943:Organophosphorus Compounds
D007202:Indicators and Reagents; D009705:Nucleosides; D009838:Oligodeoxyribonucleotides; D063065:Organophosphonates; D009943:Organophosphorus Compounds; C060627:tris(2,4,6-tribromophenoxy)dichlorophosphorane