title: The influence of ascorbic acid and lactose on the interaction of iron with each of cobalt and zinc during intestinal absorption.
abstract: The effect of ascorbic acid and lactose on the interaction between iron and each of zinc or copper during intestinal absorption was studied in normal and iron-deficient rats. It was found that addition of cobalt to the iron dose inhibited absorption of iron to 42% in normal rats and to 46.7% in iron deficient ones. The presence of zinc with the iron dose also inhibited absorption of iron to 34.6% in normal rats and to 32.2% in case of the iron deficient ones. The addition of ascorbic acid to the combined dose of Fe + Co enhanced absorption of iron by five times in normal and in iron deficient rats. In case of the combined dose of Fe + Zn the enhancement was four times in normal rats and six times in iron deficient ones. The addition of lactose to the combined dose of either Fe + Co or Fe + Zn corrected the inhibiting action of either cobalt or zinc on iron absorption. Based on these findings, it is recommended that ascorbic acid and lactose be added to therapeutic multimineral preparations.
authors.affiliation: Food Science and Nutrition Department National Research Centre, Dokki, Cairo, Egypt.
authors.forename: F A
authors.initials: FA
authors.lastname: el-Shobaki
authors.forename: M G
authors.initials: MG
authors.lastname: Srour
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D003035:Cobalt / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D007408:Intestinal Absorption / Q000187:drug effects; D007501:Iron / Q000493:pharmacokinetics*; D007785:Lactose / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000494:pharmacology*
chemical_list: D006454:Hemoglobins; D003035:Cobalt; D007501:Iron; D007785:Lactose; D015032:Zinc; D001205:Ascorbic Acid