[Effect of an extract from the cauline of Piper kadsura ohwi on endotoxin-induced hypotension and lung injury in rats].
Arterial hypotension and high-permeability pulmonary edema were induced by intravenous injection of platelet activating factor (PAF) or endotoxin in rats. Pre-treatment with extract from the Cauline of Piper kadsura attenuated endotoxin-induced hypotension and lung injury, which may result from the PAF antagonistic effect of Piper kadsura.
Li
S H
SH
Fei
X
X
Wu
Z L
ZL
Cheng
S F
SF
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D007022:Hypotension / Q000139:chemically induced / Q000188:drug therapy*; D010972:Platelet Activating Factor; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000150:complications / Q000188:drug therapy
D004365:Drugs, Chinese Herbal; D010972:Platelet Activating Factor