title: A retrospective study of 40 cases of canine pyometra-metritis treated with prostaglandin F-2 alpha and broad-spectrum antibacterial drugs.
abstract: Bitches with pyometra were treated with dinoprost, a prostaglandin F-2 alpha-THAM salt or luprostiol, a synthetic PG analogue and oral broad-spectrum antibacterial drugs. PGF-2 alpha treatment lasted 2-26 days and dosage varied from 26.8 to 258 micrograms/kg. Clinical cure from symptoms was achieved in 33/40 bitches. Of 14 bitches from which the owners opted to breed, 9 eventually produced litters. Long-term complications were anoestrus, recurrence of metritis, failure to conceive and abortion. One or more of these complications were recorded in 9 of 20 bitches for which long term information was available.
authors.affiliation: Department of Theriogenology, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Republic of South Africa.
authors.forename: R O
authors.initials: RO
authors.lastname: Gilbert
authors.forename: J O
authors.initials: JO
authors.lastname: Nöthling
authors.forename: E E
authors.initials: EE
authors.lastname: Oettle
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use; D000667:Ampicillin / Q000627:therapeutic use; D000818:Animals; D015237:Dinoprost / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004716:Endometritis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use; D012189:Retrospective Studies; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D011461:Prostaglandins F, Synthetic; D000667:Ampicillin; D000658:Amoxicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D015237:Dinoprost; C049643:luprostenol; D004318:Doxycycline