title: Creatine-kinase-BB after severe head-injury as an index of prognosis in relation to nature of trauma and patients age.
abstract: Creatine-Kinase-BB (CK-BB) is a brain specific enzyme, with a prognostic value for the patient's outcome after head-injury. We have investigated 76 brain injured patients and attempted to show a correlation of the concentrations of CK-BB and the Glasgow-Outcome-Scale (GOS). Patients with a CK-BB concentration of more than 50 ng/ml died. Patients, who had a CK-BB concentration less than 25 ng/ml showed only minimal neurological deficits. Intracerebral contusions and acute subdural haematomas showed the highest CK-BB concentration, indicating a high degree of braintissue-damage. CK-BB seems to have no correlation with the age of patients. Normalisation of elevated CK-BB levels do not correlate with recovery from neurological deficit.
authors.affiliation: Department of Neurosurgery, RWTH Aachen, Federal Republic of Germany.
authors.forename: A
authors.initials: A
authors.lastname: Niedeggen
authors.forename: D
authors.initials: D
authors.lastname: Adelt
authors.forename: R
authors.initials: R
authors.lastname: Berndt
authors.forename: T
authors.initials: T
authors.lastname: Hopf
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001930:Brain Injuries / Q000150:complications / Q000201:enzymology* / Q000503:physiopathology; D003402:Creatine Kinase / Q000378:metabolism*; D005260:Female; D006407:Hematoma, Epidural, Cranial / Q000150:complications / Q000201:enzymology / Q000503:physiopathology; D006408:Hematoma, Subdural / Q000150:complications / Q000201:enzymology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D003402:Creatine Kinase