Metabolic fate of the heart agent [18F]6-fluorometaraminol.
Studies were performed to determine whether [18F]6-fluorometaraminol (18F-FMR), a new neuronal heart radiopharmaceutical, is metabolized in vivo and if the metabolites are taken up in heart. Rat, dog, baboon and guinea pig were injected with 18F-FMR and tissue samples were analyzed for metabolites by HPLC. Liver contained the most metabolites of the tissues studied with 25-90% of the radioactivity present as metabolites at 1 h in all the species studied. While metabolites of 18F-FMR are found in blood, no significant accumulation of these metabolites is found in heart (less than or equal to 0.3%) 1 h after i.v. administration in any species except rat. These studies suggest that 18F-FMR is a suitable agent for quantitative imaging of the heart by positron emission tomography.
Rosenspire
K C
KC
Department of Internal Medicine, University of Michigan, Ann Arbor 48109.
Gildersleeve
D L
DL
Massin
C C
CC
Mislankar
S G
SG
Wieland
D M
DM
D000818:Animals; D004285:Dogs; D005260:Female; D005462:Fluorine Radioisotopes; D006168:Guinea Pigs; D006321:Heart / Q000000981:diagnostic imaging*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D008680:Metaraminol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010215:Papio; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D005462:Fluorine Radioisotopes; C054817:6-fluorometaraminol; D008680:Metaraminol