[Spontaneous production of interleukin-1 and B cell stimulating factors by B cells from patients with systemic lupus erythematosus].
In order to investigate the mechanism of polyclonal B cell activation in systemic lupus erythematosus (SLE), spontaneous production of interleukin 1 (IL-1) and B cell stimulating factor (BSF) activity by B cells from SLE patients and normal subjects were examined. In both active and inactive SLE, spontaneous IL-1 and BCDF production was significantly increased as compared with normal subjects. However, BCGF activity of B cells from patients with SLE was not significantly increased. After IL-1 activity was absorbed by anti-IL-1 antibody, BCGF and BCDF activities were remained. Low density (larger) B cells separated by Percoll gradient was significantly increased in percentage in SLE patients. However, the population of higher density (smaller) B cells could produce BCGF and BCDF activity in SLE. It is suggested that SLE B cells produce IL-1 and BSF spontaneously and that these factors may play an important role for polyclonal B cell activation in SLE.
Hirose
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D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000096:biosynthesis*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008213:Lymphocyte Activation
D007375:Interleukin-1; D015847:Interleukin-4