Red blood cell membrane cation transport in normotensive psoriatics.
Psoriasis might be a widespread membrane disorder. To verify whether under the influence of psoriasis the red cell membrane cation metabolism is altered, we compared 46 psoriatics with 23 normotensive controls. A significant increase was observed in intracellular K+ content, in the maximal velocity of the Na(+)-K+ ATPase, of the Na(+)-K(+)-Cl- outward co-transport, of the Na+/H+ exchange, as well as in the outward passive permeability for Na+. No difference was seen between the two groups in Na+ content, Li+/Na+ exchange or in the passive permeability to K+. In 8 psoriatics treated with etretinate (10-75 mg/day for 1-36 months), Na(+)-K+ ATPase, Na(+)-K(+)-Cl- co-transport and the passive permeability for Na+ were not significantly different from controls. These results suggest that the primary abnormality might be an increased Na+ influx, in part through the Na+/H+ exchange, which is compensated by increased activity of outward transports, and confirm that the red cells are a useful model for the study of membrane transport in this disease. Our results indicate also that these membrane transport abnormalities can be corrected by etretinate treatment.
Mozzato
M G
MG
Institute of Clinical Medicine, University of Padova, Italy.
Semplicini
A
A
Grosso
G
G
Ceolotto
G
G
Marzola
M
M
Pessina
A C
AC
Peserico
A
A
D000328:Adult; D000368:Aged; D002412:Cations; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005050:Etretinate / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000032:analysis*; D011565:Psoriasis / Q000188:drug therapy / Q000378:metabolism*; D012964:Sodium / Q000032:analysis*
D002412:Cations; D005050:Etretinate; D012964:Sodium; D011188:Potassium