[Inhibitors of protein biosynthesis and development of dyslipoproteinemia in rabbits].
Acute alimentary hypercholesterolemia, developing after a single load with cholesterol, and experimental atherosclerosis, caused by long-term loading with cholesterol, were studied in young rabbits. Olivomycin, administered simultaneously with long-term cholesterol loading, and streptomycin, injected within 3 days before cholesterol loading, were used as inhibitors. These antibiotics prevented hypercholesterolemia, hyperlipoproteinemia and atherosclerosis development. The data obtained suggest that the drugs used inhibited development of atherosclerosis via selective blockade of apoB proteins synthesis in liver and intestinal tissues of the experimental animals.
Frol'kis
V V
VV
Bogatskaia
L N
LN
Novikova
S N
SN
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000009:adverse effects; D006937:Hypercholesterolemia / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D006951:Hyperlipoproteinemias / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D009848:Olivomycins / Q000494:pharmacology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D013307:Streptomycin / Q000494:pharmacology
D002791:Cholesterol, Dietary; D008074:Lipoproteins; D011500:Protein Synthesis Inhibitors; D009848:Olivomycins; D002784:Cholesterol; D013307:Streptomycin
Ingibitory biosinteza belka i razvitie dislipoproteidemii u krolikov.