title: Long-term care and management of Wilson's disease in the GDR.
abstract: Diagnosis, long-term management and family investigations of Wilson's disease are provided by selected clinical institutions in the GDR. From 187 patients detected since 1949, 111 are alive. In spite of the principal effectiveness of penicillamine treatment, confirmed by the disappearance of most of the central nervous system symptoms and successful professional rehabilitation of many patients, insufficient therapeutic discipline, psychosocial disturbances and penicillamine side-effects forcing its substitution by zinc or triethylenetetramine dihydrochloride in 14 cases need our further attention.
authors.affiliation: Clinic of Neurology, Karl Marx University, Leipzig, GDR.
authors.forename: H
authors.initials: H
authors.lastname: Bachmann
authors.forename: J
authors.initials: J
authors.lastname: Lössner
authors.forename: H J
authors.initials: HJ
authors.lastname: Kühn
authors.forename: D
authors.initials: D
authors.lastname: Biesold
authors.forename: R
authors.initials: R
authors.lastname: Siegemund
authors.forename: B
authors.initials: B
authors.lastname: Kunath
authors.forename: H
authors.initials: H
authors.lastname: Willgerodt
authors.forename: B
authors.initials: B
authors.lastname: Teichmann
authors.forename: V
authors.initials: V
authors.lastname: Wieczorek
authors.forename: G
authors.initials: G
authors.lastname: Mühlau
mesh_terms: D000223:Adaptation, Psychological; D003300:Copper / Q000378:metabolism; D005500:Follow-Up Studies; D006527:Hepatolenticular Degeneration / Q000188:drug therapy* / Q000503:physiopathology / Q000534:rehabilitation; D006801:Humans; D010396:Penicillamine / Q000009:adverse effects / Q000627:therapeutic use; D012917:Social Adjustment; D013997:Time Factors
chemical_list: D003300:Copper; D010396:Penicillamine