title: [SPECT in reversible symptoms of cerebrovascular diseases].
abstract: In 16 patients with reversible symptoms of cerebrovascular disease a HMPAO- and/or IMP-SPECT was performed. 12 of these patients were suffering from TIA, 4 from PRIND. Using HMPAO-SPECT in 8 out of 9 patients with TIA and in 1 of 2 with PRIND a hypoperfusion could be demonstrated; IMP-SPECT showed a pathological pattern in 3 of 5 patients with TIA and in none of 2 patients with PRIND. A semiquantitative evaluation showed a tracer accumulation reduced by 13 +/- 12% (HMPAO) and 8 +/- 7% (IMP), respectively, in the clinically involved hemisphere, compared to the contralateral side. In circumscript SPECT lesions a reduction by 21 +/- 8% (HMPAO) or 17 +/- 7% (IMP) was observed. The interhemispheric ratio from the HMPAO-SPECT showed a significant correlation to that of the 133Xe-rCBF measurement (r = 0.86; p less than 0.001). SPECT was positive in a higher percentage than TCT, Doppler sonography, radioangiography and 133Xe-rCBF measurement. This does not imply a higher specificity or sensitivity, because a slight inhomogeneous SPECT pattern may occasionally be observed even in normal persons.
authors.affiliation: Institut für klinische und experimentelle Nuklearmedizin, Universität Bonn, BRD.
authors.forename: F
authors.initials: F
authors.lastname: Grünwald
authors.forename: K
authors.initials: K
authors.lastname: Broich
authors.forename: J
authors.initials: J
authors.lastname: Kropp
authors.forename: A
authors.initials: A
authors.lastname: Hartmann
authors.forename: H J
authors.initials: HJ
authors.lastname: Biersack
mesh_terms: D000328:Adult; D000368:Aged; D000662:Amphetamines; D002545:Brain Ischemia / Q000000981:diagnostic imaging; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D020367:Iofetamine
vernacular_title: SPECT bei reversibler Symptomatik zerebrovaskulärer Erkrankungen.