title: Comparative study of a two dose schedule of PGE2 3 mg pessary and 1700 micrograms film for induction of labour in nulliparae with poor cervical score.
abstract: Efficacy of a two dose schedule of 3 mg pessary or 1700 micrograms film of PGE2 for induction of labour was compared in nulliparae with poor cervical score. Patient characteristics in the two groups (43 in 3 mg and 40 in 1700 micrograms group) were comparable in age, period of gestation, indications for induction of labour and in their initial cervical score. The number of patients who started labour with a two dose schedule 4 hours apart were similar in each group. The improvement of cervical score, length of labour, mode of delivery and the neonatal outcome were not different in the two groups. There was no advantage of using a film preparation over that in the form of a pessary and the use of 3 mg dose did not give significantly better results compared with the 1700 micrograms dose, in terms of obstetric or neonatal outcome.
authors.affiliation: Department of Obstetrics and Gynaecology, National University of Singapore.
authors.forename: S
authors.initials: S
authors.lastname: Arulkumaran
authors.forename: P G
authors.initials: PG
authors.lastname: Adaikan
authors.forename: C
authors.initials: C
authors.lastname: Anandakumar
authors.forename: O A
authors.initials: OA
authors.lastname: Viegas
authors.forename: P
authors.initials: P
authors.lastname: Singh
authors.forename: S S
authors.initials: SS
authors.lastname: Ratnam
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects* / Q000378:metabolism; D002585:Cesarean Section; D015232:Dinoprostone / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007751:Labor, Induced; D010298:Parity / Q000187:drug effects*; D010570:Pessaries; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D015232:Dinoprostone