title: Comparison of glycolysis and glutaminolysis in Onchocerca volvulus and Brugia pahangi by 13C nuclear magnetic resonance spectroscopy.
abstract: Comparison of glycolysis in Brugia pahangi and Onchocerca volvulus by 13C nuclear magnetic resonance (NMR) spectroscopy showed that the former organism is predominantly a lactate fermenter and the latter resembles more closely the metabolism of a mixed acid fermenter producing lactate, succinate, acetate, ethanol, formate and carbon dioxide. Both organisms synthesize glycogen as a storage carbohydrate. Glutaminolysis in both organisms proceeds by the delta-amino-butyrate shunt to produce succinate which is then further metabolized to acetate and carbon dioxide as end-products.
authors.affiliation: Department of Pharmaceutical Sciences, University of Arizona, Tucson 85721.
authors.forename: N E
authors.initials: NE
authors.lastname: MacKenzie
authors.forename: E A
authors.initials: EA
authors.lastname: Van de Waa
authors.forename: P R
authors.initials: PR
authors.lastname: Gooley
authors.forename: J F
authors.initials: JF
authors.lastname: Williams
authors.forename: J L
authors.initials: JL
authors.lastname: Bennett
authors.forename: S M
authors.initials: SM
authors.lastname: Bjorge
authors.forename: T A
authors.initials: TA
authors.lastname: Baille
authors.forename: T G
authors.initials: TG
authors.lastname: Geary
mesh_terms: D000818:Animals; D002009:Brugia / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism*; D006019:Glycolysis; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy; D009854:Onchocerca / Q000378:metabolism*; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid
chemical_list: D007773:Lactates; D013386:Succinates; D005973:Glutamine; D019344:Lactic Acid; D019802:Succinic Acid