[The effect of pyrazidol and inkazan on the rotation behavior of rats].
Effect of some MAO inhibitors on rotational behavior induced by d-amphetamine in unilaterally 6-OHDA-lesioned rats was studied. Among all MAO inhibitors tested only 1-deprenyl induced rotational behavior. Nialamide, chlorgiline, pyrazidol and inkazan dose-dependently enhanced rotational behavior induced by 2 mg/kg i. p. d-amphetamine and pargiline depressed it. Nialamide and inkazan greatly enhanced rotational behavior induced by 0.5 mg/kg i. p. d-amphetamine. It is suggested that nialamide and inkazan may have similar effects on DA-ergic neurotransmission.
Mashkovskiĭ
M D
MD
Bogdanov
M B
MB
Bondarenko
N A
NA
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002227:Carbazoles / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D012399:Rotation; D013997:Time Factors
D000928:Antidepressive Agents; D002227:Carbazoles; D002243:Carbolines; D008996:Monoamine Oxidase Inhibitors; D011954:Receptors, Dopamine; C027473:metralindole; C009830:pirlindole
Vliianie pirazidola i inkazana na rotatsionnoe povedenie krys.