title: The polymeric immunoglobulin A receptor is present on hepatocytes in human liver.
abstract: A monoclonal antibody raised against human colostrum secretory component produced even staining of hepatocyte plasma membranes, as well as bile duct lining cells, in all sections examined from eight normal and three abnormal human livers. Human bile samples incubated with free secretory component degraded it to varying extents, probably proteolytically; true levels of free secretory component will therefore often be higher than those reported. It seems likely that human liver resembles that of other mammals in transferring polymeric IgA through hepatocytes to the bile by means of the polymeric IgA receptor.
authors.affiliation: Department of Clinical Biochemistry, University of Cambridge, U.K.
authors.forename: J H
authors.initials: JH
authors.lastname: Perez
authors.forename: D G
authors.initials: DG
authors.lastname: Wight
authors.forename: J I
authors.initials: JI
authors.lastname: Wyatt
authors.forename: M
authors.initials: M
authors.lastname: Van Schaik
authors.forename: B M
authors.initials: BM
authors.lastname: Mullock
authors.forename: J P
authors.initials: JP
authors.lastname: Luzio
mesh_terms: D001646:Bile / Q000032:analysis; D001652:Bile Ducts / Q000032:analysis; D002462:Cell Membrane / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D008099:Liver / Q000032:analysis* / Q000648:ultrastructure; D011108:Polymers; D011961:Receptors, Fc; D011971:Receptors, Immunologic / Q000032:analysis*; D012635:Secretory Component / Q000032:analysis
chemical_list: C045281:IgA receptor; D007070:Immunoglobulin A; D011108:Polymers; D011961:Receptors, Fc; D011971:Receptors, Immunologic; D012635:Secretory Component; C034639:polymeric IgA