title: The gene encoding the human preproacrosin (ACR) maps to the q13-qter region on chromosome 22.
abstract: Human proproacrosin is specified by a single gene (ACR). Using a series of human-rodent somatic cell hybrids containing variant complements of human chromosomes, the preproacrosin gene was found to cosegregate with human chromosome 22. Somatic cell hybrids containing translocation chromosomes carrying parts of chromosome 22 were used to locate the preproacrosin gene to the region 22q13-22qter. By probing the DNA of 82 individuals, a restriction fragment length polymorphism was found with SstI in 14 cases.
authors.affiliation: Institut für Humangenetik der Universität, Göttingen, Federal Republic of Germany.
authors.forename: I M
authors.initials: IM
authors.lastname: Adham
authors.forename: K H
authors.initials: KH
authors.lastname: Grzeschik
authors.forename: A H
authors.initials: AH
authors.lastname: Geurts van Kessel
authors.forename: W
authors.initials: W
authors.lastname: Engel
mesh_terms: D000176:Acrosin / Q000235:genetics*; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D015342:DNA Probes; D004792:Enzyme Precursors / Q000235:genetics*; D015723:Gene Library; D005796:Genes; D006801:Humans; D008297:Male; D009693:Nucleic Acid Hybridization; D012697:Serine Endopeptidases / Q000235:genetics*; D013737:Testis / Q000201:enzymology
chemical_list: D015342:DNA Probes; D004792:Enzyme Precursors; D004247:DNA; D012697:Serine Endopeptidases; C062266:preproacrosin; D000176:Acrosin