[Clearance of oxypurines in normal subjects and in gout patients subjected to a purine-free diet. Effects of allopurinol].
The clearance of uric acid, hypoxanthine and xanthine has been examined in gout patients and in normal subjects compared to creatinine, after a purine-free diet. The treatment decreased the clearance in normal subjects, but showed an opposite effect in gout patients. The clearances both of uric acid, hypoxanthine and xanthine were enhanced by allopurinol. The interpretation of the observed variations is discussed.
Porcelli
B
B
Pizzichini
M
M
Di Stefano
A
A
Leoncini
R
R
Taddeo
A
A
Marinello
E
E
D000328:Adult; D000493:Allopurinol / Q000494:pharmacology*; D003404:Creatinine / Q000493:pharmacokinetics*; D004032:Diet; D006073:Gout / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D019820:Xanthine; D014970:Xanthines / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D007042:Hypoxanthines; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D000493:Allopurinol; D003404:Creatinine
Clearance delle ossipurine nei soggetti normali e nei soggetti gottosi sottoposti a dieta apurinica. Effetti dell'allopurinolo.