Sequential combination of methotrexate and 1-beta-D-arabinofuranosylcytosine shows synergistic effect on the generation of DNA strand breaks in a human promyelocytic leukemia cell line.
Tanizawa
A
A
Department of Pediatrics, Kyoto University, Japan.
Kubota
M
M
Takimoto
T
T
Kito
T
T
Akiyama
Y
Y
Kiriyama
Y
Y
Mikawa
H
H
D001085:Arabinofuranosylcytosine Triphosphate / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology; D003561:Cytarabine / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D004249:DNA Damage; D004273:DNA, Neoplasm / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004357:Drug Synergism; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000494:pharmacology; D002955:Leucovorin / Q000494:pharmacology; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D008727:Methotrexate / Q000008:administration & dosage / Q000494:pharmacology*; D013936:Thymidine / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004273:DNA, Neoplasm; D007042:Hypoxanthines; D003561:Cytarabine; D001085:Arabinofuranosylcytosine Triphosphate; D019271:Hypoxanthine; D003513:Cycloheximide; D002955:Leucovorin; D013936:Thymidine; D008727:Methotrexate