Autoradiographic evidence of [3H]neurotensin binding changes in discrete regions of brain in the rat model of persistent spasmodic dyskinesia induced by iminodipropionitrile.
Chronic injection of iminodipropionitrile (IDPN) to rats causes a persistent set of abnormalities which includes hyperlocomotion, hyperexcitability, and dyskinetic movements of the neck. These behavioral changes are very similar to those observed after the acute administration of the dopamine (DA) agonist, amphetamine, in rodents. Because of the anatomical and functional evidence that neurotensin (NT) can modulate DA neurotransmission, the present receptor autoradiographic study investigated the binding of [3H]NT in the brains of IDPN-treated rats. There were significant decreases in binding in the frontal and cingulate cortices, the rhinal sulcus, the dorsolateral aspect of the caudate-putamen, and in the ventral tegmental area. These results provide the first evidence for the possible participation of the NT system in the manifestations of the IDPN-induced syndrome.
Przedborski
S
S
Neurological Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Wright
M
M
Fahn
S
S
Cadet
J L
JL
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D004409:Dyskinesia, Drug-Induced / Q000378:metabolism*; D008297:Male; D009496:Neurotensin / Q000378:metabolism*; D009570:Nitriles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009570:Nitriles; D009496:Neurotensin; C008110:3,3'-iminodipropionitrile