Drug-induced agranulocytosis.
Forty cases of drug-induced agranulocytosis from the Department of Medicine, Faculty of Medicine, Chiang Mai University during the 12 year period 1975-1987 were analysed. In 32 cases, the related etiologic drugs were identified. These were thiacetazone and isoniazid in 10 cases (25%), propylthiouracil in 6 cases (15%) sulfa drugs in 5 cases (12.5%) combination of analgesic and antibiotics in 3 cases (7.5%), anti-psychotic in 2 cases (5%), antibiotics in 5 cases including, ampicillin (2 cases) and others (3 cases), and ether in 1 case (2.5%). The other 8 cases (20%) received unknown drugs from private clinics. Twenty-four cases had complete recovery in 13-14 days after withdrawal of the incriminating drugs, and sixteen cases (40%) died with septicemia.
Chaimongkol
B
B
Nanthachit
N
N
Navarawong
V
V
Siriloiratana
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced* / Q000150:complications / Q000401:mortality; D002648:Child; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013785:Thailand / Q000453:epidemiology