One trial conditioning with apomorphine is blocked by cycloheximide.
Rats with unilateral 6-hydroxydopamine lesions of substantia nigra were treated with 0.05 mg/kg apomorphine and observation of their circling behavior was made. Twenty minutes after the apomorphine treatment they were injected with saline or 2 mg/kg cycloheximide. Two weeks after drug treatment, control animals exhibited rapid contralateral rotation in response to being placed in the rotation environment. This conditioned rotation was not observed in cycloheximide-treated animals. After the first test trial animals received a second apomorphine administration, this time followed by saline injection in both groups. Subsequent to the second apomorphine treatment both groups showed conditioned rotation.
Silverman
P B
PB
University of Texas Medical School, Department of Psychiatry-MSI, Houston 77030.
Baruch
N P
NP
Schultz
K A
KA
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D003513:Cycloheximide / Q000494:pharmacology*; D005260:Female; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*
D011500:Protein Synthesis Inhibitors; D003513:Cycloheximide; D001058:Apomorphine