Microheterogeneity of the carbohydrate moiety of human alpha 1-acid glycoprotein in two benign liver diseases: alcoholic cirrhosis and acute hepatitis.
To determine whether alterations of the carbohydrate moiety of human alpha 1-acid glycoprotein constitute a marker of hepatic damage we studied purified alpha 1-acid glycoprotein from healthy individuals and two groups of patients with benign liver diseases: alcoholic cirrhosis and acute viral hepatitis. The results indicate: (1) increased concanavalin A-non reactive forms in cirrhosis and hepatitis, (2) a markedly increased proportion of fucosyl residues in all cirrhotic and some hepatitis patients. Although hyperfucosylation is generally considered to be a tumor marker, the observation here in the two benign liver diseases indicates that an increased fucosyl content should be considered as a more general expression of pathological glycoconjugate metabolism.
Biou
D
D
Laboratoire de Biochimie CNRS DO 622, UER des Sciences Pharmaceutiques et Biologiques, Chatenay, Malabry, France.
Chanton
P
P
Konan
D
D
Seta
N
N
N'Guyen
H
H
Feger
J
J
Durand
G
G
D000208:Acute Disease; D000328:Adult; D002241:Carbohydrates / Q000032:analysis*; D002846:Chromatography, Affinity; D004591:Electrophoresis, Polyacrylamide Gel; D006525:Hepatitis, Viral, Human / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G / Q000276:immunology; D007202:Indicators and Reagents; D008104:Liver Cirrhosis, Alcoholic / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009961:Orosomucoid / Q000032:analysis* / Q000302:isolation & purification
D002241:Carbohydrates; D007074:Immunoglobulin G; D007202:Indicators and Reagents; D009961:Orosomucoid