[Evaluation of the late ineffectiveness of sulfonylurea derivatives in patients with diabetes mellitus hospitalized at the Gastroenterology and Metabolic Disease Clinic, Medical Academy, in Warsaw 1976-1987].
The authors made a retrospective analysis of late ineffectiveness of sulphonylurea derivatives and its correlation with the age of diabetes onset, duration of the disease, sex, body mass, smoking cigarettes, diabetes history in the family, coexistence with some diabetic complications as retinopathy, ischemic heart disease, arterial hypertension and vascular diseases in lower limbs. The study was carried out in a group of 220 patients with diabetes type 2 lasting from 1 up to 25 years, aged 30-77 undergoing therapy in the Department of Gastroenterology and Metabolic Diseases in the years 1976-1987 in whom a late ineffectiveness appeared to sulphonylurea derivatives. The average time of effective therapy by means of sulphonylurea derivatives in the group examined was 8.7 +/- 4.9 years (9.2 +/- 5.2 in men and 8.3 +/- 4.6 in women). The time of effective therapy by means of the above drugs was inversely proportional to the age of patients when diabetes type 2 appeared. The time of effective therapy by means of sulphonylurea derivatives in obese men was significantly longer than in obese women. No correlation was found between the appearance of late ineffectiveness of sulphonylurea derivatives and diabetes history in the family, smoking ischemic heart disease, arterial hypertension, retinopathy and vascular diseases of lower limbs.
Pacuła
P
P
Janeczko
E
E
Trusiewicz
D
D
Koneczna
A
A
Tomaszczyk
M
M
Dembe
K
K
Stryjek-Kamińska
D
D
D000328:Adult; D000367:Age Factors; D000368:Aged; D002747:Chlorpropamide / Q000008:administration & dosage; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006760:Hospitalization; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology*; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008297:Male; D008687:Metformin / Q000008:administration & dosage; D008875:Middle Aged; D010629:Phenformin / Q000008:administration & dosage; D013997:Time Factors
D007004:Hypoglycemic Agents; D008687:Metformin; D010629:Phenformin; D002747:Chlorpropamide
Ocena późnej nieskuteczności pochodnych sulfonylomocznika u chorych na cukrzyce hospitalizowanych w latach 1976-1987 w Klinice Gastroenterologii i Chorób Przemiany Materii Akademii Medycznej w Warszawie.