title: Fatal torsade de pointes following jaundice in a patient treated with disopyramide.
abstract: A case of fatal torsade de pointes in a 53 year old patient treated with disopyramide is described. The arrhythmia followed the development of acute hepatocellular dysfunction and may have been due to failure of the liver to efficiently degrade the drug to its metabolites.
authors.affiliation: Department of Medicine, Kaplan Hospital, Rehovot, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Schattner
authors.forename: J
authors.initials: J
authors.lastname: Gindin
authors.forename: D
authors.initials: D
authors.lastname: Geltner
mesh_terms: D004206:Disopyramide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007565:Jaundice / Q000139:chemically induced*; D008099:Liver / Q000187:drug effects; D008875:Middle Aged; D013610:Tachycardia / Q000139:chemically induced*
chemical_list: D004206:Disopyramide