Are there morphological changes in presynaptic terminals of kindled rats?
Excitatory synapses were studied in the hippocampal dentate gyrus ipsilateral to the stimulated entorhinal cortex in fully kindled rats 2 weeks after the last (3rd) stage 5 seizure. No change was observed in the absolute number of synaptic vesicles. On the other hand, marked redistribution of the vesicles in the synaptic apparatus was found, with a shift to a strategic position in the vicinity of the synaptic cleft. This redistribution evidently makes it possible to increase the supply of neurotransmitter needed for hyperfunction of the synaptic apparatus in kindling.
Hovorka
J
J
Neurology Clinic, Faculty Hospital, Motol, Czechoslovakia.
Langmeier
M
M
Mares
P
P
D000818:Animals; D006624:Hippocampus / Q000503:physiopathology / Q000648:ultrastructure*; D007696:Kindling, Neurologic; D008297:Male; D009411:Nerve Endings / Q000502:physiology / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000473:pathology* / Q000503:physiopathology; D013572:Synaptic Vesicles / Q000502:physiology / Q000648:ultrastructure*