[Electrophysiologic effects of sophocarpine on papillary muscle in guinea pig].
Sophocarpine prolonged the action potential duration of guinea pig papillary muscle in a dose-dependent manner. After the preparations were exposed to sophocarpine 50 mumol/L for 30 min, APD50 and APD90 were prolonged from 189 +/- 21 and 216 +/- 24 ms to 205 +/- 27 and 241 +/- 25 ms (P less than 0.01). Simultaneously, ERP was prolonged from 202 +/- 14 to 211 +/- 16 ms, although the ERP/APD90 ratio was not changed. Sophocarpine had no significant effects on other AP parameters. Propranolol did not block sophocarpine effects.
Zhu
P J
PJ
Liu
Y C
YC
Li
Z Y
ZY
Yu
D Z
DZ
D000200:Action Potentials / Q000187:drug effects; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents; D005260:Female; D006168:Guinea Pigs; D008297:Male; D010210:Papillary Muscles / Q000187:drug effects* / Q000502:physiology; D000093842:Matrines
D000470:Alkaloids; D000889:Anti-Arrhythmia Agents; C035933:sophocarpine; D000093842:Matrines