[Influence of four opioids on pulmonary oxygenation and naloxone's effects in mechanically ventilated dogs].
In order to examine effects of opioids on pulmonary oxygenation during constant ventilation, we investigated changes in PaO2 following four different opioids and after reversal with naloxone in mechanically ventilated, lightly anesthetized dogs. The systemic administration of morphine 1.0mg.kg-1, buprenorphine 0.03mg.kg-1, butorphanol 0.1mg.kg-1, and cyclazocine 0.05mg.kg-1, did not affect PaO2, although these opioids decreased mean arterial pressure and heart rate significantly. Naloxone 0.04mg.kg-1 after four opioids affected the hemodynamics, significantly, but it did not cause any detrimental effects on pulmonary oxygenation. Although naloxone alone did not affect mean arterial pressure and heart rate at all, subsequent morphine decreased mean arterial pressure and heart rate significantly. Neither naloxone nor subsequent morphine produced any change in PaO2. The results suggest that reversal with naloxone may not cause any significant influences on pulmonary oxygenation in mechanically ventilated and anesthetized patients.
Takahashi
H
H
Dohi
S
S
Matsumiya
N
N
Takeshima
R
R
Naito
H
H
D000818:Animals; D002047:Buprenorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002077:Butorphanol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003496:Cyclazocine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D009019:Morphinans / Q000494:pharmacology*; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology*; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D012121:Respiration, Artificial
D009019:Morphinans; D009270:Naloxone; D002047:Buprenorphine; D009020:Morphine; D003496:Cyclazocine; D002077:Butorphanol