Hyperpolarizing action of cromakalim on the rat aorta.
Cromakalim alone at 1 microM had no effect and at 10 microM hyperpolarized the rat aorta. The rat aorta was depolarized by KCl (20 mM), noradrenaline (0.3 microM) and 5-hydroxytryptamine (1 microM). In the presence of depolarization with KCl, noradrenaline or 5-hydroxytryptamine, cromakalim at 1 and 10 microM hyperpolarized the rat aorta. Thus the antispasmogenic actions of modest concentrations of cromakalim is compatible with potassium channel opening.
Doggrell
S A
SA
Department of Pharmaceutical Sciences, Aston University, Birmingham, U.K.
Smith
J W
JW
Downing
O A
OA
qilson
K A
KA
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001578:Benzopyrans / Q000494:pharmacology*; D019806:Cromakalim; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D001578:Benzopyrans; D011758:Pyrroles; D019806:Cromakalim; D011189:Potassium Chloride; D006916:5-Hydroxytryptophan; D009638:Norepinephrine