Loss of neurons from the intracerebellar nuclei of the ageing mouse.
The intracerebellar nuclei of the ASH/TO mouse brain were examined at 6, 22, 25, 28 and 31 months of age using quantitative histological techniques. Neuron number remained constant between 6 and 22 months of age but there was a statistically significant (P less than 0.01) decrease in neuronal number between 22 and 31 months of age with neuron number declining from 6970 +/- 690 at 22 months to 4140 +/- 246 at 31 months of age. Neuronal nuclear diameter remained constant between 6 and 25 months of age but increased from 10.6 +/- 0.6 microns at 25 months to 12.2 +/- 0.3 microns at 31 months of age. Whether this was due to an actual increase in nuclear diameter or to a proportionately greater loss of small neurons is not known.
Sturrock
R R
RR
Department of Anatomy, University of Dundee, Scotland.
D000375:Aging / Q000473:pathology*; D000818:Animals; D002452:Cell Count; D002529:Cerebellar Nuclei / Q000254:growth & development / Q000473:pathology*; D051379:Mice