Piroxicam affects collagen changes around experimental intestinal anastomoses.
The effects of piroxicam on postoperative changes of collagen--measured as hydroxyproline--concentrations were measured around intestinal anastomoses in rats. Piroxicam, in a dose of 2 mg/kg/day, significantly reduced the decrease of hydroxyproline concentrations around colonic anastomoses during the first 3 days after the operation but also reduced the increase of hydroxyproline concentrations observed at day 7 around ileal anastomoses in the control group. 10 mg piroxicam/kg/day resulted in a 100% lethal peritonitis after the 5th postoperative day. We suggest that piroxicam affects collagen metabolism by inhibiting granulocyte functions.
Mastboom
W J
WJ
Department of General Surgery, St. Radboud University Hospital, Nijmegen, The Netherlands.
Hendriks
T
T
van Elteren
P
P
de Boer
H H
HH
D000714:Anastomosis, Surgical; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D003106:Colon / Q000378:metabolism / Q000601:surgery*; D006909:Hydroxyproline / Q000378:metabolism; D007082:Ileum / Q000378:metabolism / Q000601:surgery*; D008297:Male; D010894:Piroxicam / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D015431:Weight Loss; D014945:Wound Healing / Q000187:drug effects*
D010894:Piroxicam; D003094:Collagen; D006909:Hydroxyproline