Fluctuation of the biochemiluminescence from PMN leukocytes in a family with a high prevalence of severe periodontitis.
Rapidly progressive periodontal disease was found in three patients belonging to three different generations of the same family. Beyond the clinical inspection, blood examination allowed measurements of the luminol enhanced biochemiluminescence from the circulating PMN leukocytes. Abnormally low values were recorded in the affected individuals (75, 84 and 138 mVolts per 10(6) cells) whereas a sample of healthy individuals exhibited photonic values from 240 up to 910 mVolts per 10(6) cells. These abnormal values, however, were not constantly recorded. They gave way to higher PMN activity indices after the patients had been treated either by antibiotics, scaling, debridement or classical pocket cleaning.
Courtois
P
P
Laboratoire de Stomatologie, Université Libre de Bruxelles, Faculté de Médecine, Belgique.
Mandelbaum
I M
IM
Labbe
M
M
Pourtois
M
M
D000293:Adolescent; D000368:Aged; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D010375:Pedigree; D010518:Periodontitis / Q000097:blood* / Q000235:genetics / Q000628:therapy