Therapeutic and hypothermic properties of diazepam altered by a diazepam-chlorpromazine association.
Rats were injected (IP) with diazepam (2.5 mg/kg) and chlorpromazine (10.0 mg/kg) with a 30-min interval between the two injections. After 10-12 repeated drug pairings of this type, the thermic, muscle relaxant, and anxiolytic responses of the animals to diazepam alone were tested. These tests revealed: 1) an enhanced hypothermia (rectal temperature), 2) an attenuated muscle relaxant effect (inclined plane test), and 3) a potentiated anxiolytic effect (plus-maze test). Although various interdrug associations have previously been demonstrated using other measures of conditioning, this is the first instance in which changes in the therapeutic effects of a drug (in this case, muscle relaxation and anxiety reduction) have been obtained with this procedure.
Taukulis
H K
HK
University of New Brunswick, Saint John, Canada.
Brake
L D
LD
D000818:Animals; D001007:Anxiety; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects*; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology*; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004347:Drug Interactions / Q000502:physiology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D051381:Rats
D003975:Diazepam; D002746:Chlorpromazine