The role of Dirofilaria immitis antigen in the pathogenesis of pulmonary arteritis in the dog. 1. The effects of antigen infusion.
The aim of this study was to investigate the correlation between the Dirofilaria immitis antigen and morphology response of pulmonary tissue. The pulmonary arteries of D. immitis naive dogs were infused with an antigenic extract of adult female D. immitis worms. Light and electron microscopy and an assessment of vascular permeability were performed to compare arterial pathology 1 h and 5 days after antigen infusion. Thrombus formation accompanied by perivascular edema was present initially, but it was not detectable after 5 days.
Tarish
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JH
Atwell
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D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D001158:Arteries; D001167:Arteritis / Q000209:etiology / Q000662:veterinary*; D004183:Dirofilaria immitis / Q000276:immunology*; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D005260:Female; D005370:Filarioidea / Q000276:immunology*; D008168:Lung / Q000098:blood supply* / Q000473:pathology; D008297:Male
D000947:Antigens, Helminth