[Pathology of the reproductive apparatus of cells under the action of remantadine and deitiforin].
The antiviral effect of chemical agents remantadine and deutephorine on the reproductive apparatus of MDCK-cells was studied. It was established that the action of the chemical agents during 3-4 days induced enhancement in pathologically transformed mitoses. This enhancement was in direct proportion to the doses used and to the cultivation time. Dose dependent enhancement of the total pathological mitoses number was simultaneous with the redistribution of mitoses into groups: the relative number of pathologies connected with chromosome damage became lower and the number of degenerating mitoses grew. Computer regression analysis showed the linear dependence between the chemical agent dose and the number of mitoses in the metaphase, that gives an indirect evidence of statmokinetic action of the agents under study.
Votiakov
V I
VI
Erokhina
I R
IR
Amvros'eva
T V
TV
Rusiaev
V A
VA
D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008938:Mitosis / Q000187:drug effects; D009930:Organic Chemicals; D012299:Rimantadine / Q000494:pharmacology*; D013997:Time Factors
D000998:Antiviral Agents; D009930:Organic Chemicals; D012299:Rimantadine; C060204:deitiforin; D000218:Adamantane
O patologii reproduktivnogo apparata kletok pri deĭstvii remantadina i deĭtiforina.