Effect of prostaglandin E2 and indomethacin on blood flow in the lower urinary tract of the rabbit.
The effect of the cyclooxygenase system on lower urinary tract blood flow was investigated in a standardized rabbit model with empty bladder. Twenty-eight New-Zealand white rabbits were separated into 3 groups. The first group received 1 mg per kg b.w. s.c. daily of PGE2 for 4 days. The second group received 10 mg per kg of indomethacin perorally daily for 7 days. The third group served as controls. The experiments were undertaken in general anaesthesia. Regional blood flow of the lower urinary tract was measured with 141Ce-labeled microspheres and plasma volume was assessed by the equilibrium distribution of 125I-labeled fibrinogen in tissues. Peroral treatment with indomethacin caused a significant increase in blood flow in the trigone. No difference in whole bladder blood flow was found and no differences were found among groups with respect to plasma volume.
Eika
B
B
Urological Department K, Aarhus Kommunehospital, Denmark.
Keller
J
J
Hansen
E S
ES
Frøkiaer
J
J
D000818:Animals; D015232:Dinoprostone / Q000494:pharmacology*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D014551:Urinary Tract / Q000098:blood supply*
D015232:Dinoprostone; D007213:Indomethacin