Structure of a protected C(1)-C(10) subunit of erythronolides A and B.
C19H34O4, Mr = 326.48, orthorhombic, P2(1)2(1)2(1), a = 7.949 (2), b = 14.880 (5), c = 17.047 (5) A, V = 2016 (1) A3, Z = 4, Dx = 1.08 g cm-3, mu = 0.6861 cm-1, lambda(Mo K alpha) = 0.71069 A, F(000) = 720, T = 163 K, R = 0.0644 for 1476 reflections [Fo greater than or equal to 4 sigma (Fo)]. There is an intermolecular H bond involving the hydroxyl group and the carbonyl O (related by 1/2 + x, 3/2 - y, 1 - z) with an O...O distance of 2.838 (5) A, an H...O distance of 2.06 (5) A and an O-H...O angle of 172 (6) degrees. There are no such intramolecular contacts.
Lynch
V M
VM
Department of Chemistry, University of Texas, Austin 78712.
Pacofsky
G J
GJ
Martin
S F
SF
Davis
B E
BE
D003461:Crystallography; D004917:Erythromycin / Q000031:analogs & derivatives*; D015394:Molecular Structure
C038316:erythronolide A; C038315:erythronolide B; D004917:Erythromycin