Cord transferrin and ferritin values for erythropoiesis in newborn infants of diabetic mothers.
Neonatal polycythemia is a perinatal complication in infants of diabetic mothers. The cord CBC (complete blood counts), serum iron, transferrin and ferritin concentrations were studied in newborn infants of 9 GDM (gestational diabetes), 21 NIDDM (noninsulin-dependent diabetes mellitus), and 8 IDDM (insulin-dependent diabetes mellitus) mothers. The RBC (red blood cell) count, Hb (hemoglobin) and Hct (hematocrit) of these infants were higher than control infants. There was no difference between the serum iron concentration of the infants of each group diabetic mothers and the infants in the control group, but the transferrin concentration was significantly higher and the ferritin was significantly lower in the infants of diabetic mothers than in those of control mothers. There was a significant negative correlation between transferrin and ferritin (r = -0.491 p less than 0.001). Erythropoiesis is considered to be enhanced in the fetuses of diabetic mothers, and the iron needed for erythropoiesis is reportedly transported from the mother to the fetus according to the demands of the fetus, but the iron storage was shown to be reduced in the fetuses of diabetic mothers.
Murata
K
K
Department of Obstetrics and Gynecology, Mie University School of Medicine, Tsu, Japan.
Toyoda
N
N
Ichio
T
T
Ida
M
M
Sugiyama
Y
Y
D000328:Adult; D004920:Erythropoiesis; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007501:Iron / Q000097:blood; D008297:Male; D008431:Maternal-Fetal Exchange; D011086:Polycythemia / Q000097:blood; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D014168:Transferrin / Q000378:metabolism*
D014168:Transferrin; D005293:Ferritins; D007501:Iron