[Hemosorption in the treatment of aspirin-induced bronchial asthma].
Oral aspirin test was performed in 50 asthma patients. Of them 18 patients exhibited idiosyncrasy to the drug. All the patients were subjected to hemosorption. Subsequently, 16 patients achieved remission. The hemosorption resulted in reduction of tracheobronchial hypersensitivity, especially to PGE2 alpha. Phagocytosis and T-cell immunity returned to normal. Sixteen patients underwent aspirin desensitization which had a more potent action on the function of beta-adrenergic receptors of the smooth muscles of the bronchi. Complete desensitization in 3 patients was recorded only after 1-3 hemosorption sessions.
Didkovskiĭ
N A
NA
Treskunov
V K
VK
Zakharzhevskaia
T V
TV
Evseev
N G
NG
Shmeleva
T K
TK
D000328:Adult; D001241:Aspirin / Q000009:adverse effects* / Q000276:immunology; D001249:Asthma / Q000139:chemically induced / Q000628:therapy*; D001980:Bronchi / Q000187:drug effects* / Q000276:immunology; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000150:complications / Q000628:therapy*; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D008297:Male
D001241:Aspirin
Gemosorbtsiia v lechenii bol'nykh aspirinovoĭ bronkhial'noĭ astmoĭ.