Beneficial effect of coinfusing a lipid emulsion on venous patency.
The hypothesis that infused fat could prolong venous patency was tested in a paired crossover design. Parenterally fed newborn infants received, for a given level of energy, (60 vs 80 kcal/kg/day), two 6-day isocaloric and isonitrogenous (434 +/- 3.4 mg/kg/day, n = 32) regimens differing only by the fat intake (LF: 1.03 +/- 0.02, HF: 2.78 +/- 0.05 g/kg/day). Paired comparisons of osmolarities within isocaloric (60 or 80 kcal/kg/day) infusions showed that high fat regimens were associated with significantly lower osmolarities. A paired comparison of patency times showed that the drop in osmolarity produced by the high fat regimen at 60 kcal/kg/day led to a significantly longer venous patency time. The comparison of patency times between regimens (LF, 60 kcal/kg/day) and HF, 80 kcal/kg/day) with same osmolarities (702 mOsm/liter) and glucose intakes (11 g/kg/day) documented that the fat emulsion per se had a vascular protective effect. This observation demonstrates that the coinfusion of a lipid emulsion exerts a beneficial effect, whether biochemical or biophysical, on the vascular endothelium of peripheral veins.
Pineault
M
M
Perinatal Service and Research Center, Hôpital Sainte-Justine, Montreal, Quebec, Canada.
Chessex
P
P
Piedboeuf
B
B
Bisaillon
S
S
D005217:Fat Emulsions, Intravenous / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007263:Infusions, Parenteral / Q000009:adverse effects*; D014654:Vascular Patency / Q000187:drug effects*
D005217:Fat Emulsions, Intravenous