title: [The natural occurring incidence of chromosome abnormalities in 330 chorionic villi samples in the first trimester of pregnancy].
abstract: The natural occurring incidence of chromosome abnormalities (ICA) and its clinical significance were investigated in 330 chorionic villi samples (CVS) from the first trimester of pregnancy. It was found that the ICACVS was 5.67 per cent (11/194) in the normal group and 11.77 per cent (16/136) in the risk group. The difference between two groups was highly significant (P less than 0.01). The result shows that the pregnant women with threatened abortion, history of spontaneous abortion and greater than or equal to 40 years old are the high-risk factors. Special attention should be paid to these cases in clinical genetic counselling and prenatal diagnosis.
authors.forename: J H
authors.initials: JH
authors.lastname: Ren
mesh_terms: D000033:Abortion, Threatened / Q000235:genetics*; D000328:Adult; D000367:Age Factors; D002681:China / Q000453:epidemiology; D002824:Chorionic Villi / Q000648:ultrastructure; D002869:Chromosome Aberrations / Q000453:epidemiology*; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis