[Antiaggregatory and anticoagulant effects of oligoamines. 10. Tertiary oligoamines and quaternary ammonium salts].
Twelve tertiary oligoamines, two quaternary oligoammonium salts, two oligoamides, one oligosulfonamide, and one trinitrosamine were tested for antiplatelet and anticoagulant effects. Seven amines and one ammonium compound inhibited platelet aggregation at IC50 below 100 mumols/L. The results suggest that the formation of hydrogen bonds to phospholipids strengthens the antiplatelet activity. The sterical limits of the structural variability concerning the antiaggregatory effects are shown.
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D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D000925:Anticoagulants / Q000138:chemical synthesis*; D006801:Humans; D066298:In Vitro Techniques; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis*; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D000588:Amines; D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D000644:Quaternary Ammonium Compounds
Antiaggregatorische und anticoagulante Eigenschaften von Oligoaminen, 10. Mitt.: Oligotertiäre Amine und oligoquartäre Ammoniumsalze.