title: Pulmonary shunting after cardiopulmonary bypass.
abstract: The effect of cardiopulmonary bypass (CPB) on pulmonary function was investigated in 32 adult patients, including 23 patients undergoing coronary artery bypass grafting and nine patients undergoing heart-valve replacement. Clinical indicators for pulmonary insufficiency, such as chest X-ray, gas exchange and lung function tests were measured. Transthoracic electrical impedances were measured, and the mean specific thoracic impedance (RHO) was calculated. (RHO is an accurate indicator for the intrathoracic fluid content; low RHO values correspond with high intrathoracic fluid content.) Significant postoperative decreases in RHO were paralleled by a significant impairment of gas exchange. Chest X-rays demonstrated accumulation of intrathoracic fluid. Lung function tests showed significant postoperative decreases in lung volumes and vital capacity. These findings are consistent with the concept that CPB provokes an inflammatory reaction in the lung. The non-invasive RHO measurement proved to be simple and in good agreement with clinical indicators. This method may be a real asset in the prevention and treatment of pulmonary dysfunction after CPB. The possibility of calibrating RHO with respect to absolute values of intrathoracic fluid content should be investigated.
authors.affiliation: Department of Anesthesiology, Catharina Hospital, Eindhoven, The Netherlands.
authors.forename: H H
authors.initials: HH
authors.lastname: Korsten
authors.forename: J A
authors.initials: JA
authors.lastname: Leusink
authors.forename: J
authors.initials: J
authors.lastname: Spierdijk
authors.forename: J H
authors.initials: JH
authors.lastname: Meijer
authors.forename: J E
authors.initials: JE
authors.lastname: Beneken
authors.forename: W G
authors.initials: WG
authors.lastname: Zijlstra
mesh_terms: D002307:Cardiography, Impedance; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D015633:Extravascular Lung Water; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008875:Middle Aged; D011659:Pulmonary Gas Exchange; D011859:Radiography; D015656:Respiratory Mechanics