title: Metachromin C, a new cytotoxic sesquiterpenoid from the Okinawan marine sponge Hippospongia metachromia.
abstract: A new sesquiterpenoid quinone, metachromin C[1], with potent cytotoxic activity has been isolated together with a known terpenoid metachromin A[2] from the Okinawan marine sponge Hippospongia metachromia and the structure determined by spectroscopic data, especially several types of 2D nmr spectra including 1H-detected heteronuclear multiple-bone correlation (HMBC).
authors.affiliation: Mitsubishi Kasie Institute of Life Sciences, Minamiooya, Machida, Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Murayama
authors.forename: Y
authors.initials: Y
authors.lastname: Ohizumi
authors.forename: T
authors.initials: T
authors.lastname: Ohta
authors.forename: S
authors.initials: S
authors.lastname: Nozoe
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D016227:Benzoquinones; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011161:Porifera / Q000032:analysis*; D011817:Rabbits; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014662:Vasoconstrictor Agents / Q000302:isolation & purification*
chemical_list: D000970:Antineoplastic Agents; D016227:Benzoquinones; D012717:Sesquiterpenes; D014662:Vasoconstrictor Agents; C062203:metachromin C