title: A case of primary aldosteronism with chronic renal failure undergoing hemodialysis treatment.
abstract: A 56-year-old man with primary aldosteronism and chronic renal failure undergoing hemodialysis is described. He complained of numbness of the extremities and showed persistent hypopotassemia in spite of anuria. In the endocrinological examination, a very high plasma aldosterone concentration was observed, while plasma renin activity was within the normal range. From the abdominal Computed Tomography (CT), adrenal scintigraphy, and segmental venous sampling data, he was diagnosed as primary aldosteronism due to left adrenocortical adenoma. In this case, hypopotassemia could not be explained by potassium loss through the kidneys, which suggests potassium excretion in the gastrointestinal tract as the mechanism of hypopotassemia. This was clearly shown from a potassium-balance study and the results of spironolactone administration. Our report is on the first case showing hypopotassemia due to primary aldosteronism in spite of anuria. If a patient treated with maintenance dialysis should have persistent hypopotassemia, as in the present report, it is necessary to consider an association with primary aldosteronism.
authors.affiliation: Second Department of Internal Medicine, Sapporo Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsuda
authors.forename: K
authors.initials: K
authors.lastname: Shimamoto
authors.forename: N
authors.initials: N
authors.lastname: Ura
authors.forename: H
authors.initials: H
authors.lastname: Ogata
authors.forename: Y
authors.initials: Y
authors.lastname: Shizukuda
authors.forename: M
authors.initials: M
authors.lastname: Iwakura
authors.forename: A
authors.initials: A
authors.lastname: Nozawa
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
authors.forename: O
authors.initials: O
authors.lastname: Iimura
mesh_terms: D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000175:diagnosis; D007008:Hypokalemia / Q000175:diagnosis / Q000209:etiology; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000378:metabolism; D006435:Renal Dialysis; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D011188:Potassium