Physiological pharmacokinetic model of hexachlorobenzene in the rat.
A physiologically based pharmacokinetic model was developed to describe the distribution of hexachlorobenzene (HCB) in the rat after oral administration or injection. The model was based on flow-limited blood perfusion of HCB to tissues and organs of the body. A set of simultaneous differential equations were solved for the different tissue concentrations as a functions of time. The model allowed for elimination of HCB by excretion. The model also allowed for differential growth of various tissues over the course of an experiment. Computer simulations using the model indicated that growth of animals during the course of dosing experiments can greatly increase the apparent half-life of HCB.
Freeman
R A
RA
Monsanto Co., St. Louis, MO 63167.
Rozman
K K
KK
Wilson
A G
AG
D000818:Animals; D002722:Chlorobenzenes / Q000493:pharmacokinetics*; D003198:Computer Simulation; D006581:Hexachlorobenzene / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D002722:Chlorobenzenes; D006581:Hexachlorobenzene