[The effect of carnosine on the healing of a lung wound].
The influence of carnosine (beta-alanine, alpha-histidine) on the process of lung wound reparation was studied in 90 guinea-pigs. Its efficacy was evaluated microscopically, histologically and by means of electronic microscope. It was established that carnosine, as compared to controls nearly twice accelerates reparative processes in the injured lung by activation of fibroblast proliferation, connective tissue generation and intracellular regeneration. In type II epithelial cells more intensive formation of osmiophilic bodies and lamellar bodies contained in them is observed. The alveolus formation in the wound lips by the 7-8th day after lung injury is going on under the carnosine influence, which is due, probably, to massive excretion of osmiophilic contents from type II epithelial cells and surfactant production. This may be connected with rapid decrease of atelectasis and rapid restoration of lung airness within the wound.
Perel'man
M I
MI
Kornilova
Z Kh
ZKh
Paukov
V S
VS
Boĭkov
A K
AK
Priĭmak
A A
AA
D000818:Animals; D002336:Carnosine / Q000627:therapeutic use*; D004151:Dipeptides / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D008168:Lung / Q000187:drug effects / Q000648:ultrastructure; D055370:Lung Injury; D008297:Male; D008854:Microscopy, Electron; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*; D014951:Wounds, Stab / Q000188:drug therapy* / Q000473:pathology
D004151:Dipeptides; D002336:Carnosine
Vliianie karnozina na zazhivlenie rany legkogo.