Mechanism of La Crosse virus inhibition by ribavirin.
The effect of ribavirin on the growth and replication of La Crosse virus was examined. The data suggest that low concentrations of ribavirin have a marked effect on the initial steps of La Crosse virus transcription. The therapeutic potential of ribavirin in the treatment of human California encephalitis serotype infections is discussed in light of these findings.
Cassidy
L F
LF
Division of Infectious Diseases, Children's Hospital, Boston, Massachusetts.
Patterson
J L
JL
D002043:Bunyaviridae / Q000187:drug effects*; D002586:Cesium / Q000494:pharmacology; D002712:Chlorides; D002141:Encephalitis Virus, California / Q000187:drug effects* / Q000502:physiology; D004670:Encephalitis, California / Q000188:drug therapy; D019384:Nucleic Acid Synthesis Inhibitors; D010441:Peptide Chain Elongation, Translational / Q000187:drug effects; D012254:Ribavirin / Q000494:pharmacology* / Q000627:therapeutic use; D012263:Ribonucleosides / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D002712:Chlorides; D019384:Nucleic Acid Synthesis Inhibitors; D012263:Ribonucleosides; D002586:Cesium; D012254:Ribavirin; C028019:cesium chloride