Interleukin-1 beta stimulates the release of vasopressin from rat neurohypophysis.
The release of vasopressin from the isolated superfused rat neurohypophysis was measured. The electrically evoked release of vasopressin after phasic submaximal stimulation was increased on exposure to the cytokine, interleukin-1 beta (44 pM). The release returned to its control level when the peptide was withdrawn. The results indicates a permissive role of interleukin-1 beta in the release of vasopressin.
Christensen
J D
JD
Department of Biology, Royal Danish School of Pharmacy, Copenhagen O.
Hansen
E W
EW
Fjalland
B
B
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D004558:Electric Stimulation; D007375:Interleukin-1 / Q000494:pharmacology*; D007457:Iodine Radioisotopes; D008297:Male; D010904:Pituitary Gland, Posterior / Q000187:drug effects / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D014667:Vasopressins / Q000378:metabolism*
D007375:Interleukin-1; D007457:Iodine Radioisotopes; D014667:Vasopressins; D001127:Arginine Vasopressin