Comparative antiulcer and antisecretory effects of various calcium antagonists.
1. The antiulcer activity (ethanol or indomethacin-induced ulcers) and the antisecretory effects (pylorus-ligated rats) of various selective and non selective calcium antagonists were studied. 2. Flunarizine and pirenzepine reduce the ethanol-ulcer length whereas diltiazem and cimetidine are weakly active and verapamil, nifedipine and nicardipine are ineffective. 3. All tested compounds except verapamil prevent the development of indomethacin-induced ulceration. 4. All substances, except flunarizine decrease the total H+ output in Shay rats. 5. The activities of the different compounds are discussed in terms of their mode of action.
Hertz
F
F
Laboratoires UPSA, Rueil-Malmaison, France.
Cloarec
A
A
D000818:Animals; D000897:Anti-Ulcer Agents; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D000431:Ethanol; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D007202:Indicators and Reagents; D007213:Indomethacin; D008297:Male; D011708:Pylorus / Q000502:physiology; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy
D000897:Anti-Ulcer Agents; D002121:Calcium Channel Blockers; D007202:Indicators and Reagents; D000431:Ethanol; D007213:Indomethacin