Effect of pindolol on changes in serum lipids induced by hydrochlorthiazide.
Forty-two patients with essential hypertension, WHO I-II, and a diastolic blood pressure greater than or equal to 100 mm Hg, were initially given 25 mg hydrochlorthiazide alone. After treatment for 3 months 10 mg pindolol was also given to 16 of them as the diastolic blood pressure had not been reduced to less than or equal to 90 mm Hg. After 3 months treatment on hydrochlorthiazide alone there was a significant increase in serum cholesterol, low density lipoprotein cholesterol and triglyceride concentrations, and a decrease in high density lipoprotein cholesterol concentration, and this pattern persisted after a further 3 months on the single drug regimen. In contrast, in those patients who received additional treatment with pindolol after the first 3 months, there was a significant decrease in the low density lipoprotein cholesterol and an increase in high density lipoprotein cholesterol during the following 3 months. Thus, the addition of pindolol to hydrochlorthiazide therapy appeared to reverse the negative effects on the lipid profile induced by the diuretic alone.
Frithz
G
G
Department of Medicine, Central Hospital, Eskilstuna, Sweden.
D000328:Adult; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects* / Q000627:therapeutic use; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010869:Pindolol / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D006852:Hydrochlorothiazide; D002784:Cholesterol; D010869:Pindolol