title: A hungarian study on Werdnig-Hoffmann disease.
abstract: The prevalence of Werdnig-Hoffmann disease was found to be 0.66 per 10,000 livebirths in Hungary from 1973 to 1980. However, the true prevalence is estimated to be 1 per 10,000 livebirths, which exceeds the level of a previously published English study. There was no higher fetal death rate in previous and subsequent pregnancies of index patients' mothers. The occurrence in sibs was 32%, probably because of greater ascertainment in families with more than one affected child.
authors.affiliation: Department of Human Genetics and Teratology, National Institute of Hygiene, Budapest, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Czeizel
authors.forename: J
authors.initials: J
authors.lastname: Hamula
mesh_terms: D005787:Gene Frequency; D006801:Humans; D006814:Hungary; D009134:Muscular Atrophy, Spinal / Q000453:epidemiology*; D014897:Spinal Muscular Atrophies of Childhood / Q000453:epidemiology* / Q000235:genetics