[Use of cephalosporins in pediatric practice with the study of the immunoleukolysis (leukocytolysis) reaction].
The aim of the study was to determine the value of preliminary assay of hypersensitivity to cephalosporin antibiotics such as cephazolin, cefuroxime and cefotaxime with the immunoleukolysis test (ILT). 130 children at the age of 2 months to 7 years treated with one of the antibiotics for various inflammatory diseases of the bronchopulmonary system were examined. Hypersensitivity (the ILT indices over 30 per cent) was observed in 9.2 per cent of the children with respect to cephazolin (kefzol), in 3.9 per cent of the children with respect to cefuroxime (ketocef) and in 0.8 per cent of the children with respect to cefotaxime (klaforan). The results of the ILT combined with those of the conjunctival test allowed to increase the number of indications to differential use of the cephalosporins in children with various pathological processes in the bronchopulmonary system.
Poshekhonov
S A
SA
Vorotchenkova
L M
LM
Stepanova
A G
AG
D002511:Cephalosporins / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D007223:Infant; D007958:Leukocyte Count / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology; D007970:Leukopenia / Q000139:chemically induced*; D012141:Respiratory Tract Infections / Q000188:drug therapy*
D002511:Cephalosporins
Naznachenie tsefalosporinov v pediatricheskoĭ praktike s uchetom reaktsii immunoleĭkoliza (leĭkotsitoliza).