title: Hamster placental lactogen-II contains a structural feature unique among the growth hormone-prolactin-placental lactogen family.
abstract: Sequence analysis of cDNA for hamster placental lactogen-II (PL-II) revealed that while this protein has a high degree of sequence homology to mouse and rat PL-II it contains a pair of cysteine residues not present in the mouse and rat proteins or in any other known member of the GH-PRL-PL protein family. This unique pair of cysteine residues may be responsible for the extreme tendency of hamster PL-II, compared to other members of the GH-PRL-PL family, to form disulfide-bonded hormone-serum protein complexes.
authors.affiliation: Department of Biology, University of California, Santa Cruz 95064.
authors.forename: J N
authors.initials: JN
authors.lastname: Southard
authors.forename: L
authors.initials: L
authors.lastname: Do
authors.forename: W C
authors.initials: WC
authors.lastname: Smith
authors.forename: F
authors.initials: F
authors.lastname: Talamantes
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D006224:Cricetinae / Q000235:genetics*; D003545:Cysteine; D004247:DNA / Q000235:genetics; D005260:Female; D005796:Genes; D008647:Mesocricetus / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D010908:Pituitary Hormones, Anterior / Q000235:genetics*; D010928:Placental Lactogen / Q000235:genetics*; D011247:Pregnancy; D051381:Rats; D012689:Sequence Homology, Nucleic Acid
chemical_list: D010908:Pituitary Hormones, Anterior; C062303:placental lactogen II; D004247:DNA; D010928:Placental Lactogen; D003545:Cysteine