A comparison of the effects of 6-hydroxydopamine and reserpine on noradrenergic and peptidergic nerves in rat brown adipose tissue.
While co-existence of noradrenaline and neuropeptide-Y is, by inference, indicated in sympathetic nervous projections to rat interscapular brown adipose tissue by the fact of their coincident disappearance from the tissue following 6-hydroxydopamine treatment of the animals, reserpine treatment produced a divergent effect suggestive of possible differences either in the localisation and/or release mechanisms for noradrenaline and the peptide within the same neurons. Thus reserpine produced a depletion of noradrenaline but not of the immunohistochemically demonstrable neuropeptide-Y in the nerve plexuses of the tissue.
Mukherjee
S
S
Department of Anatomy, University of Wales College of Cardiff, UK.
Lever
J D
JD
Norman
D
D
Symons
D
D
Spriggs
T L
TL
Jung
R T
RT
D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000294:innervation*; D000818:Animals; D009474:Neurons / Q000187:drug effects*; D009478:Neuropeptide Y / Q000378:metabolism; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000378:metabolism; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology* / Q000031:analogs & derivatives; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000378:metabolism
D009478:Neuropeptide Y; D012701:Serotonin; C027803:6-hydroxytryptamine; D012110:Reserpine; D009638:Norepinephrine