Methotrexate increases the activation and cytotoxicity of 5-fluorouracil: detected by 19F n.m.r. in vivo.
McSheehy
P M
PM
C.R.C. Biomedical Magnetic Resonance Research Group, St. George's Medical School, London, U.K.
Prior
M J
MJ
Griffiths
J R
JR
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001711:Biotransformation / Q000187:drug effects; D002279:Carcinoma 256, Walker / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000493:pharmacokinetics; D009682:Magnetic Resonance Spectroscopy; D008727:Methotrexate / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains
D005472:Fluorouracil; D008727:Methotrexate