title: [The induction of the beta state of the comuton regulation of mitochondrial oxidative phosphorylation by 2,4-DNP and malonate].
abstract: The effect of 2,4-DNP and malonate on tissue-specific uncoupling of oxidative phosphorylation (OP) of rat liver and kidney mitochondria by homologous comutons has been studied. The addition of 2,4-DNP in the presence of comuton induced beta state of comuton regulation. Transfer of liver mitochondria from alpha to beta state also resulted from partial inhibition of succinate dehydrogenase activity of addition of 0.25-0.35 mM malonate. This suggests that the transfer to beta state may be caused by de-energization of mitochondria.
authors.forename: M A
authors.initials: MA
authors.lastname: Chelidze
authors.forename: G M
authors.initials: GM
authors.lastname: Elbakidze
mesh_terms: D019297:2,4-Dinitrophenol; D000818:Animals; D004140:Dinitrophenols / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008314:Malonates / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D009928:Organ Specificity / Q000187:drug effects / Q000502:physiology; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D051381:Rats; D014475:Uncoupling Agents / Q000494:pharmacology*
chemical_list: D004140:Dinitrophenols; D008314:Malonates; D014475:Uncoupling Agents; C030290:malonic acid; D019297:2,4-Dinitrophenol
vernacular_title: Induktsiia beta-sostoianiia komutonnoĭ reguliatsii okislitel'nogo fosforilirovaniia mitokhondriĭ 2,4-DNF i malonatom.