title: Antiphospholipid antibody syndrome presenting with complex partial seizures and transient ischaemic attacks due to widespread small cerebral arterial thrombosis.
abstract: The neuropathological findings in a young man with the antiphospholipid antibody syndrome presenting with complex partial seizures and transient ischaemic attacks are described. Whilst some of his symptoms could be attributed to large vessel thrombosis, the dominant pathological process was widespread small cerebral arterial thrombosis causing extensive microinfarcts within the cerebral cortex. These findings help to explain the neurological manifestations of the antiphospholipid antibody syndrome.
authors.affiliation: Department of Pathology, University of Nottingham Medical School, Queen's Medical Centre.
authors.forename: I H
authors.initials: IH
authors.lastname: Leach
authors.forename: G
authors.initials: G
authors.lastname: Lennox
authors.forename: T
authors.initials: T
authors.lastname: Jaspan
authors.forename: J
authors.initials: J
authors.lastname: Lowe
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002220:Carbamazepine / Q000627:therapeutic use; D004833:Epilepsy, Temporal Lobe / Q000209:etiology*; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000209:etiology* / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000209:etiology*; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D010743:Phospholipids / Q000276:immunology*; D013577:Syndrome
chemical_list: D010743:Phospholipids; D002220:Carbamazepine; D008790:Metoprolol