[The possibility of peripheral cholinolytic action of psychostimulants].
The cholinolytic effect of sydnophen discovered in earlier anesthetized cats was confirmed on unanesthetized fish and frogs: the vagal bradycardia induced by electric stimulation of peripheral vagal end was decreased or even abolished by intravenous injection of sydnophen (0.2-20 mg/kg). The amphetamine (0.2-30 mg/kg) also blocked the vagal bradycardia in anesthetized cats and unanesthetized frogs. The maximum vagolytic action of amphetamine appeared later (in 4-8 min after injection) in compared with sydnophen (1-3 min). The small dose of amphetamine (0.2-0.3 mg/kg) in contrast to sydnophen didn't decrease the vagal bradycardia but even increased it. It was suggested that the cholinolytic effect of sydnophen and amphetamine is due to different mechanisms.
Samonina
G E
GE
Mandriko
E V
EV
Karazeeva
E P
EP
Kopylova
G N
GN
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004562:Electrocardiography / Q000187:drug effects; D005399:Fishes; D006339:Heart Rate / Q000187:drug effects; D010276:Parasympatholytics; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011898:Ranidae; D013558:Sydnones / Q000494:pharmacology; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology
D010276:Parasympatholytics; D011619:Psychotropic Drugs; D013558:Sydnones; C013271:sydnophen; D000661:Amphetamine
Vozmozhnost' perifericheskogo kholinoliticheskogo deĭstviia nekotorykh psikhostimuliatorov.