Electrostatic interaction in the reaction between porphyrin and DNA.
The association of tetrakis(4-N-methylpyridyl)porphine with salmon testes DNA in solution has been investigated in the presence of ethanol at 25 degrees C. It was found that the association constant was 1.14 x 10(6) M-1 and it increased with increasing the mole fraction of added ethanol. The behavior was very different from that in the case of usual intercalaters.
Sugimoto
N
N
Department of Chemistry, Faculty of Science, Konan University, Kobe, Japan.
Hasegawa
K
K
Monden
N
N
Sasaki
M
M
D000818:Animals; D004247:DNA / Q000187:drug effects / Q000378:metabolism*; D004560:Electricity; D000431:Ethanol / Q000494:pharmacology; D011166:Porphyrins / Q000378:metabolism*; D012474:Salmon; D013053:Spectrophotometry
D011166:Porphyrins; C021096:tetra(4-N-methylpyridyl)porphine; D000431:Ethanol; D004247:DNA