A controlled study of the ocular effects of tamoxifen in conventional dosage in the treatment of breast carcinoma.
The use of tamoxifen is expanding in its application in the treatment of breast carcinoma, and proposed prophylactic use. Tamoxifen in high dosage and in some reports at conventional dosage is associated with ocular toxicity. This study in a single blind fashion examined 79 patients receiving tamoxifen for varying treatment durations at conventional dosage and 115 patients not receiving tamoxifen. No ocular toxicity was found. Further follow up studies are required to ensure no toxicity develops in patients receiving high cumulative dosage on conventional therapy.
Longstaff
S
S
Department of Ophthalmology, Ninewells Hospital, Dundee, U.K.
Sigurdsson
H
H
O'Keeffe
M
M
Ogston
S
S
Preece
P
P
D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000188:drug therapy*; D002386:Cataract / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000139:chemically induced*; D008875:Middle Aged; D013629:Tamoxifen / Q000008:administration & dosage / Q000009:adverse effects*
D013629:Tamoxifen