title: Effect of Zizyphus sativa leaves on blood glucose levels in normal and alloxan-diabetic rats.
abstract: An alcoholic extract of Zizyphus sativa leaves was tested for hypoglycemic activity in normal and alloxan-diabetic rats. Single (100-400 mg/kg) oral doses of extract to normal animals showed a dose-dependent statistically significant lowering of blood glucose 2, 4 and 6 h later. The effect was most pronounced at 6 h with blood glucose returning to control values at 24 h. In alloxan-diabetic rats, no significant effect was observed with extract and tolbutamide. The minimum lethal dose was greater than 3000 mg/kg, orally in mice.
authors.affiliation: Department of Pharmacology, Regional Research Laboratory, Jammu Tawi, India.
authors.forename: K K
authors.initials: KK
authors.lastname: Anand
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: D
authors.initials: D
authors.lastname: Chand
authors.forename: B K
authors.initials: BK
authors.lastname: Chandan
authors.forename: V N
authors.initials: VN
authors.lastname: Gupta
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D007194:India; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D014044:Tolbutamide / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts; D014044:Tolbutamide