Granulocyte migration ability in subjects hypersensitive to aspirin.
The reported study was carried out on 32 patients with atopic asthma. Twenty-seven patients had atopic asthma and were hypersensitive to aspirin. Twenty patients were hypersensitive only to aspirin. At the time of the investigation the patients were in the remission period at the beginning of the investigations and the lowest aspirin dose producing hypersensitivity symptoms was established in each case. It ranged from 0.05 to 0.5 g. In the group of patients hypersensitive to aspirin were included those in whom spirometric measurements demonstrated a FEV1 fall below 20% of the initial level. In all the patients and controls studied the "in vitro" granulocyte migration test was done by Clausen's method and "in vivo" by Southam's method. As shown in the presented results, patients with aspirin hypersensitivity have a defect in the migration of granulocytes of the vascular and tissue pools.
Matusiewicz
R
R
I Department of Internal Diseases. Grochow Hospital, Warsaw, Poland.
Lebiedowski
K
K
Czajkowski
M
M
Wacek
W
W
D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced / Q000209:etiology / Q000473:pathology*; D002464:Cell Migration Inhibition; D002634:Chemotaxis, Leukocyte; D004342:Drug Hypersensitivity / Q000209:etiology / Q000473:pathology*; D005260:Female; D005541:Forced Expiratory Volume; D006098:Granulocytes / Q000473:pathology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications; D008297:Male; D011058:Pollen
D001241:Aspirin