CSF phenylacetic acid and hostility in paranoid schizophrenia.
Lumbar cerebrospinal fluid concentrations of phenylacetic acid were significantly elevated in paranoid vs. nonparanoid schizophrenics. Further, phenylacetic acid concentrations were correlated with hostility. These results are consistent with the hypothesis that phenylethylamine, the proposed precursor of phenylacetic acid, plays a role in schizophrenia.
Faull
K F
KF
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305.
King
R J
RJ
Barchas
J D
JD
Csernansky
J G
JG
D000328:Adult; D006791:Hostility; D006801:Humans; D008297:Male; D010648:Phenylacetates / Q000134:cerebrospinal fluid*; D011569:Psychiatric Status Rating Scales; D012563:Schizophrenia, Paranoid / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D012565:Schizophrenic Psychology
D010648:Phenylacetates; C025136:phenylacetic acid