[Antigenic variability of avian influenza virus A/H13, isolated in the USSR].
The antigenic structure of influenza H13 viruses isolated from wild birds in the USSR in 1976-1985 was studied. Antiserum against the reference A/gull/Maryland/704/77 (H13N6) strain was used to demonstrate the antigenic variations among the viruses. The homology of nucleotide sequences in the region 99-215 for the two A/H13N6 strains, A/gull/Maryland/704/77 and A/great black-headed gull/Astrakhan/227/84, were 75% and 86%, respectively. The 9-base segment deletion in A/grey black-headed gull/Astrakhan/277/84 was observed. Comparison of the predicted amino acid sequences of the strains' hemagglutinin in the appropriate region (amino acids 2-40) revealed 5 replacements (86% homology). Two replacements of arginine by lysine and asparagine by serine in positions 15 and 16, respectively, are the most significant. The latter replacement is accompanied by a change in the glycosylation site and might alter its three-dimensional structure. Further studies of the isolate genome are under way.
Iamnikova
S S
SS
Kovtun
T O
TO
Dmitriev
G A
GA
Shemiakin
I G
IG
Semenova
N P
NP
L'vov
D K
DK
Chambers
T
T
Vebster
R
R
D000595:Amino Acid Sequence; D000940:Antigenic Variation; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology*; D001483:Base Sequence; D006389:Hemagglutinins, Viral / Q000235:genetics; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology*; D008969:Molecular Sequence Data; D011863:Radioimmunoassay; D012689:Sequence Homology, Nucleic Acid; D014764:Viral Proteins / Q000032:analysis
D000956:Antigens, Viral; D006389:Hemagglutinins, Viral; D014764:Viral Proteins
Antigennaia varibel'nost' virusov grippa ptits A/H13, izolirovannykh v SSSR.