[HLA and keloids: antigenic frequency and therapeutic response].
Twenty keloid subjects were typed for class 1 (HLA-A, B and C) and class 2 (HLA-DR and DQ) histocompatibility antigens. Their frequencies were compared to those found in control populations. Of all the antigens belonging to class 1, B 21 was more prevalent in patients. The findings regarding class 2 antigens were noteworthy: in keloid patients there was a significant prevalence of DR 5 (RR = 3.54 and 7.93 respectively for the two control groups) and DQw 3 (RR = 16.8). The patients typed for HLA-antigens were treated with corticosteroid infiltrations. The responses to the treatments were no related to the histocompatibility antigens.
Rossi
A
A
Bozzi
M
M
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D006680:HLA Antigens / Q000032:analysis*; D006683:HLA-DQ Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D015805:HLA-DR5 Antigen / Q000032:analysis; D006801:Humans; D015552:Injections, Intralesional; D007627:Keloid / Q000188:drug therapy / Q000276:immunology*; D014222:Triamcinolone Acetonide / Q000008:administration & dosage
D000305:Adrenal Cortex Hormones; D006680:HLA Antigens; D006683:HLA-DQ Antigens; C051569:HLA-DQ3 antigen; D006684:HLA-DR Antigens; D015805:HLA-DR5 Antigen; D014222:Triamcinolone Acetonide
HLA e cheloidi. Frequenze antigeniche e risposte terapeutiche.