title: Platypnea-orthodeoxia and progressive autonomic failure.
abstract: Platypnea-orthodeoxia has been described in patients with pulmonary shunts, intracardiac shunts, and severe lung disease. We report a case of platypnea-orthodeoxia in a patient with minimal obstructive lung disease and progressive autonomic failure. We have shown our patient's symptoms to be the result of an orthostatic increase in ventilation-perfusion mismatching and to be corrected with fluid challenge.
authors.affiliation: Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland.
authors.forename: J L
authors.initials: JL
authors.lastname: Fox
authors.forename: E
authors.initials: E
authors.lastname: Brown
authors.forename: J K
authors.initials: JK
authors.lastname: Harrison
authors.forename: J
authors.initials: J
authors.lastname: Williams
authors.forename: P B
authors.initials: PB
authors.lastname: Terry
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000503:physiopathology; D004417:Dyspnea / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D011187:Posture
chemical_list: D010100:Oxygen