title: [Benzonitrile and derivatives. Synthesis and pharmacological study of alkyl para-cyanophenoxy alkanoates on the central nervous system].
abstract: The results obtained by the pharmacological study of alkyl para-cyanophenoxy alkanoates seem to indicate that these derivatives present a sedative effect on the central nervous system. This activity increases with the number of methyl groups substituted, on ethyl para-cyanophenoxy acetate (except the motricity composent), most probably because of an increase in lipophily and therefore in the fixation on the central nervous system.
authors.forename: S
authors.initials: S
authors.lastname: Kirkiacharian
authors.forename: J R
authors.initials: JR
authors.lastname: Goma
authors.forename: S L
authors.initials: SL
authors.lastname: Cheav
authors.forename: J
authors.initials: J
authors.lastname: Bretaudeau
authors.forename: O
authors.initials: O
authors.lastname: Foussard-Blanpin
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000494:pharmacology; D002492:Central Nervous System Depressants; D004347:Drug Interactions; D006993:Hypnotics and Sedatives; D008297:Male; D051379:Mice; D009570:Nitriles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D002491:Central Nervous System Agents; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D009570:Nitriles; C014356:benzonitrile
vernacular_title: Benzonitrile et dérivés. Synthèse et étude pharmacologique de para-cyanophénoxy-alcanoates d'alkyle sur le système nerveux central.