Effects of ethanol on the NMR characteristics of rat brain. Acute administration, dependency, and long-term effects.
In rats, neither acute administration of ethanol nor the establishment of ethanol dependence by chronic administration for 28 days produced significant 1H-NMR relaxation changes. However, chronic ethanol intake for six months produced a transient rise in T1, with no change in T2 or water content. The significance of these results for study in man is discussed and a hypothesis is proposed to explain discrepant differences between T1, T2 and water content. It is suggested that T1 change with long-term ethanol exposure is related to altered free/bound water state secondary to cell membrane changes.
Besson
J A
JA
Department of Mental Health, University of Aberdeen.
Greentree
S G
SG
Foster
M A
MA
Rimmington
J E
JE
D000435:Alcoholic Intoxication / Q000473:pathology*; D000437:Alcoholism / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000473:pathology*; D000431:Ethanol / Q000493:pharmacokinetics; D005227:Fatty Acids / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008560:Membrane Fluidity / Q000502:physiology; D008563:Membrane Lipids / Q000032:analysis*; D009474:Neurons / Q000473:pathology; D010743:Phospholipids / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D014882:Water-Electrolyte Balance / Q000502:physiology
D005227:Fatty Acids; D008563:Membrane Lipids; D010743:Phospholipids; D000431:Ethanol