Assessment of haemolytic and thromboembolic potentials--from CFD studies of Starr-Edwards cardiac valve prostheses.
Quantitative assessments of haemolysis, thromboembolism and endothelial damage are established using computational fluid dynamics and documented threshold values. The régime studied was steady forward (systolic) flow through a fully open Starr-Edwards model 1260 ball valve, in an aortic shaped chamber. Modelling was carried out using finite difference techniques for turbulent, Newtonian flow. Haemolysis was not predicted "in-bulk", but a haemolytic potential as high as 30% was suggested at prosthetic surfaces. Also a 10% thromboembolic potential and a 6% potential for endothelium damage were noted.
Tansley
G D
GD
Mazumdar
J
J
Noye
B J
BJ
Craig
I H
IH
Thalassoudis
K
K
D001021:Aortic Valve; D004730:Endothelium, Vascular / Q000293:injuries*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006461:Hemolysis; D006801:Humans; D008433:Mathematics; D015233:Models, Statistical; D012016:Reference Values; D013923:Thromboembolism / Q000209:etiology*