Metachromin C, a new cytotoxic sesquiterpenoid from the Okinawan marine sponge Hippospongia metachromia.
A new sesquiterpenoid quinone, metachromin C[1], with potent cytotoxic activity has been isolated together with a known terpenoid metachromin A[2] from the Okinawan marine sponge Hippospongia metachromia and the structure determined by spectroscopic data, especially several types of 2D nmr spectra including 1H-detected heteronuclear multiple-bone correlation (HMBC).
Kobayashi
J
J
Mitsubishi Kasie Institute of Life Sciences, Minamiooya, Machida, Tokyo, Japan.
Murayama
T
T
Ohizumi
Y
Y
Ohta
T
T
Nozoe
S
S
Sasaki
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D016227:Benzoquinones; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011161:Porifera / Q000032:analysis*; D011817:Rabbits; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014662:Vasoconstrictor Agents / Q000302:isolation & purification*
D000970:Antineoplastic Agents; D016227:Benzoquinones; D012717:Sesquiterpenes; D014662:Vasoconstrictor Agents; C062203:metachromin C