Effect of shosaikoto, daisaikoto and sannoshashinto (traditional Japanese and Chinese medicines) on experimental hyperlipidemia in rats.
Effect of Sannoshashinto, Shosaikoto and Diasaikoto, Japanese and Chinese traditional medicinal mixtures (kampohozai), on cholesterol-induced hypercholesterolemia, aging-induced hyperlipidemia and cholesterol turnover were studied in rats. Sannoshashinto, Shosaikoto and Daisaikoto reduced the hypercholesterolemia induced by a high cholesterol diet and Sannoshashinto and Daisaikoto improved the atherogenetic index. Liver total cholesterol as increased by a high cholesterol diet was reduced by all three kampohozai. Furthermore, the increases of serum and liver triglyceride were also inhibited. In an experiment using untreated aging rats, both serum total cholesterol and serum triglyceride levels were increased. The aging-induced increases of serum total cholesterol were inhibited by Sannoshashinto and Daisaikoto and the increases of serum triglyceride were reduced by all three kampohozai. These drugs showed no effect on cholesterol biosynthesis in liver. Sannoshashinto, however, appeared to accelerate the disappearance of cholesterol from blood, while Daisaikoto inhibited the cholesterol absorption from the intestine.
Umeda
M
M
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Amagaya
S
S
Ogihara
Y
Y
D000375:Aging / Q000378:metabolism; D000818:Animals; D001599:Berberine / Q000627:therapeutic use; D002784:Cholesterol / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004338:Drug Combinations / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005419:Flavonoids / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D000960:Hypolipidemic Agents; D007564:Japan; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts; D051381:Rats; D011919:Rats, Inbred Strains; D013634:Tannins / Q000627:therapeutic use
D002791:Cholesterol, Dietary; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D013634:Tannins; C051121:daisaikoto; C062798:sannoshashinto; C461321:shosaikoto-go-keishika-shakuyakuto; D001599:Berberine; D002784:Cholesterol