Pressor responses of clonidine injected into some prosencephalic areas of conscious rats.
The objective of this investigation was to study the effect of clonidine injection into some prosencephalic areas of unanesthetized rats on mean arterial pressure (MAP) and heart rate (HR). Injection of 40 nmol clonidine in 1.0 lambda 150 mM NaCl into the medial septal area, lateral hypothalamus, lateral preoptic area and lateral ventricle caused the same increase in MAP, 38 +/- 3 to 41 +/- 5 mmHg, and decrease in HR, -65 +/- 10 to -94 +/- 13 bpm (mean +/- SEM, N = 9 to 11 animals). These results show that clonidine can act on several prosencephalic areas to induce a pressor response in the conscious rat.
Colombari
E
E
Departamento de Ciências Fisiológicas, Faculdade de Odontologia, Universidade Estadual Paulista, Araraquara, SP, Brasil.
Saad
W A
WA
Camargo
L A
LA
Renzi
A
A
De-Luca Júnior
L A
LA
Marcelino
A C
AC
Menani
J V
JV
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000502:physiology*; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003000:Clonidine