[Effects of intravenous administration of bupivacaine on the renal sympathetic nerve activity in the cat].
The effects of an i.v. bolus injection of sub-seizure doses of bupivacaine on the renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP) and heart rate (HR) were studied in cats. The cats received intravenous administration of bupivacaine (0.4 mg.kg-1, 0.8 mg.kg-1 and 1.2 mg.kg-1 at 50- and 110-min interval respectively in order of increasing doses) during nitrous oxide anesthesia and nitrous oxide-halothane anesthesia. During nitrous oxide anesthesia, MAP and HR did not change significantly with all doses of bupivacaine. RSNA increased at first and then decreased slightly following all doses of bupivacaine. In cats with denervated baroceptor, a change of RSNA after bupivacaine 0.8 mg.kg-1 i.v. was similar to that in intact cats. In contrast, RSNA, MAP and HR decreased significantly following bupivacaine 1.2 mg.kg-1 i.v. during nitrous oxide-halothane anesthesia. Cardiovascular depression following bupivacaine i.v. during nitrous oxide-halothane anesthesia may be caused by both a decreased sympathetic activity and a direct myocardial depression.
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D000769:Anesthesia, Inhalation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine / Q000008:administration & dosage / Q000494:pharmacology*; D002415:Cats; D006339:Heart Rate / Q000187:drug effects; D007262:Infusions, Intravenous; D007668:Kidney / Q000294:innervation*; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology
D002045:Bupivacaine