The effect of tooth extraction on periodontal ligament mechanoreceptors represented in the mesencephalic nucleus of the cat.
When a force is applied to a tooth, mechanoreceptors in the periodontal ligament are stimulated. When teeth are extracted the remnants of the periodontal ligament break down and disappear, but it is not known what happens to the mechanoreceptor neurones that innervated it. The present study seeks to determine the effect of tooth extraction on the population of periodontal ligament mechanoreceptor neurones represented in the mesencephalic nucleus of the fifth cranial nerve. The incisor and canine teeth were extracted from adult cats; terminal experiments were performed between 7.5 months and 2 yr later. Recordings were made in the mesencephalic nucleus with microelectrodes, and neurones were identified in the inferior alveolar nerve that previously innervated the periodontal ligament of one of the extracted mandibular teeth. The majority of these neurones responded only to electrical stimuli applied to the edentulous ridge of the mandible in the area where the incisor or canine teeth had previously been. It was not possible to stimulate them mechanically, despite the use of large forces. A small number had reinnervated new soft-tissue sites. They could be mechanically stimulated and were found adjacent to the area in which the mandibular incisor and canine teeth had been. Thus the population of periodontal ligament mechanoreceptor neurones represented in the mesencephalic nucleus do not all degenerate after tooth extraction. As the majority of those still present do not appear to reinnervate new tissues in which they can be mechanically stimulated, it is unlikely that they have any functional role after tooth loss.
Linden
R W
RW
Biomedical Sciences Division, King's College London, England.
Scott
B J
BJ
D000818:Animals; D001369:Axons / Q000502:physiology; D002415:Cats; D004558:Electric Stimulation; D007576:Jaw, Edentulous, Partially / Q000473:pathology; D008340:Mandibular Nerve / Q000033:anatomy & histology*; D008465:Mechanoreceptors / Q000033:anatomy & histology / Q000502:physiology*; D008636:Mesencephalon / Q000033:anatomy & histology*; D009061:Mouth Mucosa / Q000294:innervation; D009434:Neural Pathways / Q000033:anatomy & histology; D010513:Periodontal Ligament / Q000294:innervation*; D010521:Periosteum / Q000294:innervation; D010812:Physical Stimulation; D012867:Skin / Q000294:innervation; D014081:Tooth Extraction