title: Monoclonal antibody-coated magnetite particles as contrast agents in magnetic resonance imaging of tumors.
abstract: A highly specific and powerful magnetic resonance imaging contrast agent has been prepared by coating magnetite (Fe3O4) particles with monoclonal antibodies directed against a tumor antigen. The preparation maintains both the immunoreactivity of the monoclonal antibody and the full relaxing capability of the magnetite particle. MRI image contrast by spin-echo methods can be easily induced in a concentration range of 1-10 nM of the antibody-coated magnetite particles.
authors.affiliation: Biocenter of the University of Basel, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Cerdan
authors.forename: H R
authors.initials: HR
authors.lastname: Lötscher
authors.forename: B
authors.initials: B
authors.lastname: Künnecke
authors.forename: J
authors.initials: J
authors.lastname: Seelig
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D002277:Carcinoma / Q000175:diagnosis; D002460:Cell Line; D003110:Colonic Neoplasms / Q000175:diagnosis; D052203:Ferrosoferric Oxide; D006801:Humans; D007501:Iron; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000175:diagnosis*; D010087:Oxides; D051381:Rats
chemical_list: D000911:Antibodies, Monoclonal; D010087:Oxides; D007501:Iron; D052203:Ferrosoferric Oxide