Effects of nicergoline in experimental models related to pathogenesis of migraine.
The effect of nicergoline on cerebral blood flow (CBF), cerebrovascular resistance, the constriction of cerebral vessels caused reflectorily or by 5-hydroxytryptamine (5-HT) and on the transport of 5-HT in rat brain synaptosomes was studied using different experimental models. Nicergoline reduced cerebrovascular resistance in the carotid and vertebrobasilar system. The drug decreased carotid blood flow and local cortical CBF, preceded in some experiments by short-lasting CBF increase. Nicergoline almost completely inhibited brain vessels responses in the carotid and vertebrobasilar systems after tibial nerve stimulation. Simultaneously, inhibition of reflectory discharges of the sympathetic nerves was observed. Nicergoline showed an antiserotonin action by antagonizing the 5-HT effect on the cerebral circulation and inhibiting 5-HT-induced constriction of isolated rabbit basilar artery. The inhibition of uptake and enhancement of the release of 5-HT from brain synaptosomes indicates its ability to affect neuronal transmission in serotoninergic neurons. The effects of nicergoline are probably involved in the realization of its antimigraine action.
Mirzoyan
R S
RS
Pharmacological Research Institute of USSR Academy of Medical Sciences, Moscow.
Ganshina
T S
TS
Pukhalskaya
T G
TG
Volobueva
T I
TI
Vedernikov
Y P
YP
Dikova
M
M
Nikolova
M
M
Nikolov
R
R
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004195:Disease Models, Animal; D004873:Ergolines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology*; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009530:Nicergoline / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D014655:Vascular Resistance / Q000187:drug effects
D004873:Ergolines; D012701:Serotonin; D009530:Nicergoline