title: Preclinical investigations of the safety, immunogenicity and efficacy of a purified, inactivated tick-borne encephalitis vaccine.
abstract: A new tick-borne encephalitis (TBE) vaccine for human use has been developed. TBE virus (TBEV) was propagated in primary chick embryo cells, inactivated by formalin and purified by continuous-flow density gradient centrifugation. The TBE vaccine was tested for innocuity, immunogenicity and protective capacity in a series of laboratory tests. The results indicated that the vaccine is outstandingly well tolerated, highly immunogenic in various laboratory animals, and induces protective immunity in mice. These data suggest that this new vaccine should be studied in clinical trials.
authors.affiliation: Behringwerke AG, Marburg, F.R.G.
authors.forename: U
authors.initials: U
authors.lastname: Klockmann
authors.forename: H L
authors.initials: HL
authors.lastname: Bock
authors.forename: V
authors.initials: V
authors.lastname: Franke
authors.forename: B
authors.initials: B
authors.lastname: Hein
authors.forename: G
authors.initials: G
authors.lastname: Reiner
authors.forename: J
authors.initials: J
authors.lastname: Hilfenhaus
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D000956:Antigens, Viral / Q000302:isolation & purification; D002478:Cells, Cultured; D002642:Chick Embryo; D004591:Electrophoresis, Polyacrylamide Gel; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D006168:Guinea Pigs; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D008252:Macaca fascicularis; D051379:Mice; D011749:Pyrogens / Q000032:analysis; D051381:Rats; D015164:Vaccines, Inactivated / Q000276:immunology / Q000633:toxicity; D014765:Viral Vaccines / Q000276:immunology* / Q000633:toxicity
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D011749:Pyrogens; D015164:Vaccines, Inactivated; D014765:Viral Vaccines