[Simulation of the electroretinographic slow P III component by injection of K+-free Ringer's solution in the frog retina].
A decrease in extracellular potassium concentration [( K+]o) was caused by injecting a small amount of K+ -free Ringer's solution into the photoreceptor layer of the isolated frog retina. The response induced by K+ -free Ringer's solution was receptor side-positive, and the depth profile of the response resembled that of the response (slow P III) induced by spot illumination. This result supports the notion that the slow P III is generated by Müller cells as they hyperpolarize in response to a light-induced decrease in [K+]o in the photoreceptor layer.
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D000818:Animals; D004596:Electroretinography; D005071:Evoked Potentials / Q000187:drug effects; D005110:Extracellular Space / Q000378:metabolism; D066298:In Vitro Techniques; D007267:Injections; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000494:pharmacology*; D010786:Photoreceptor Cells / Q000378:metabolism / Q000502:physiology; D011188:Potassium / Q000378:metabolism*; D011892:Rana catesbeiana; D012160:Retina / Q000378:metabolism / Q000502:physiology*; D000077331:Ringer's Solution
D007552:Isotonic Solutions; D000077331:Ringer's Solution; D011188:Potassium