Immunolocalization of cathepsin D in dental tissues.
Cathepsin D antigenicity was localized at the light and electron microscopic levels within dental cells, but not in extracellular matrix. Different intracellular sites for cathepsin D were found depending on the cell type: the enzyme was detected in secretory vesicles of the odontoblasts and in the lysosome-like structures of the ameloblasts. Otherwise, these results suggest that the secretory vesicles of the odontoblasts may contain both cathepsin D and type I collagen. These data might implicate cathepsin D in the enamel and the dentin formations.
Andujar
M B
MB
Laboratoire d'Histophysiologie et Pathologie des Tissus Dentaires, Faculté d'Odontologie, Lyon, France.
Hartmann
D J
DJ
Caillot
G
G
Ville
G
G
Magloire
H
H
D000818:Animals; D000906:Antibodies / Q000276:immunology; D000941:Antigens / Q000032:analysis; D002402:Cathepsin D / Q000032:analysis* / Q000276:immunology; D003094:Collagen / Q000032:analysis; D051379:Mice; D009804:Odontoblasts / Q000032:analysis* / Q000648:ultrastructure; D011817:Rabbits; D011863:Radioimmunoassay
D000906:Antibodies; D000941:Antigens; D003094:Collagen; D002402:Cathepsin D