title: A conjugate of prednisolone with albumin is pharmacologically active in macrophages.
abstract: In order to selectively deliver prednisolone to macrophages, this drug was coupled to human albumin. In experiments in vitro the conjugate entered into macrophages in much higher amounts than in fibroblasts; in the former cells it was pharmacologically active as demonstrated by the inhibition of prostaglandin E2 and thromboxane A2 production. Prednisolone-albumin conjugate might be useful in research on steroids; moreover in some pathological conditions it might produce the therapeutic effects of these drugs without causing their side effects.
authors.forename: L
authors.initials: L
authors.lastname: Fiume
authors.forename: M
authors.initials: M
authors.lastname: Chiricolo
authors.forename: C
authors.initials: C
authors.lastname: Busi
authors.forename: A
authors.initials: A
authors.lastname: Mattioli
authors.forename: C
authors.initials: C
authors.lastname: Spinelli
authors.forename: G
authors.initials: G
authors.lastname: Spinosa
authors.forename: G
authors.initials: G
authors.lastname: Bartolini
authors.forename: L
authors.initials: L
authors.lastname: Minghetti
authors.forename: M
authors.initials: M
authors.lastname: Orlandi
authors.forename: V
authors.initials: V
authors.lastname: Tomasi
mesh_terms: D000418:Albumins / Q000008:administration & dosage; D000818:Animals; D004337:Drug Carriers; D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D008264:Macrophages / Q000187:drug effects*; D011239:Prednisolone / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000418:Albumins; D004337:Drug Carriers; D007457:Iodine Radioisotopes; D011239:Prednisolone