title: The effect of topically applied corticosteroids and zinc on the metallothionein content of skin in an experimental model.
abstract: The metallothionein (MT) content in hairless mouse skin was determined after topical application of various glucocorticoids or zinc oxide (ZnO). Dexamethasone (1%) in a cream base or zinc paste (20% zinc oxide) were applied twice daily, at a dose of 0.5 g, to the dorsal surface of the mouse. These experiments were conducted for 7 days. The MT content of the skin increased in a time-dependent manner after dexamethasone application with maximal values (7.1 +/- 0.29 pmol MT/mg wet weight) seen after 5 days, whereas zinc paste caused only slight increases after 3 days of treatment. The effect of hydrocortisone and triamcinolone-acetonide on the MT content of the skin was also studied. The physiological significance of these results is briefly discussed.
authors.forename: M M
authors.initials: MM
authors.lastname: Frings
authors.forename: P P
authors.initials: PP
authors.lastname: Kind
authors.forename: G
authors.initials: G
authors.lastname: Goerz
authors.forename: J
authors.initials: J
authors.lastname: Abel
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D006854:Hydrocortisone; D008668:Metallothionein / Q000032:analysis*; D051379:Mice; D008812:Mice, Hairless; D012867:Skin / Q000032:analysis*; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D008668:Metallothionein; D014222:Triamcinolone Acetonide; D015032:Zinc; D006854:Hydrocortisone