Antianoxic action of evodiamine, an alkaloid in Evodia rutaecarpa fruit.
In order to determine the antianoxic potential of evodiamine, its effects were compared to those of vinpocetine (VPT), using a series of animal models of anoxia. In mice, evodiamine was equivalent to VPT in the KCN-induced anoxia model but was greater than VPT in the low-pressure-induced anoxia model. Its effectiveness was increased by combined treatment with physostigmine, suggesting the involvement of a cholinergic mechanism in the antianoxic action of evodiamine.
Yamahara
J
J
Kyoto Pharmaceutical University, Japan.
Yamada
T
T
Kitani
T
T
Naitoh
Y
Y
Fujimura
H
H
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants; D001274:Atmospheric Pressure; D004088:Dihydroergotoxine / Q000494:pharmacology; D000860:Hypoxia / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology; D010936:Plant Extracts; D010946:Plants, Medicinal / Q000032:analysis*; D011190:Potassium Cyanide; D011799:Quinazolines / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects; D014748:Vinca Alkaloids / Q000494:pharmacology
D000470:Alkaloids; D000927:Anticonvulsants; D010936:Plant Extracts; D011799:Quinazolines; D014748:Vinca Alkaloids; D004088:Dihydroergotoxine; C013983:vinpocetine; C049639:evodiamine; D010424:Pentobarbital; D011190:Potassium Cyanide