title: Immunohistochemical study of types I, III and IV collagen in diseased human gingiva of patients with rapidly progressive periodontitis: a light and electron microscopic study.
abstract: The distribution of type I, III and IV collagens and their ultrastructural organization have been studied in diseased gingival connective tissue of patients with rapidly progressive periodontitis. This disease is characterized by acute destruction of the gingival collagenous components. The use of an immunofluorescent procedure has shown that the diseased connective tissue was made up of both type I and III collagens but that type III collagen was less resistant to acute inflammation. Ultrastructural immunolabelling, using the peroxidase procedure has shown that the large, dense bundles of type I collagen of PI, the main pattern of organization of the gingival connective tissue offered a better resistance to acute destruction than PII, a loose pattern of organization mainly composed of type III collagen. Type IV collagen was exclusively located in degraded lamina densa of basement membrane.
authors.forename: C
authors.initials: C
authors.lastname: Chavrier
authors.forename: M L
authors.initials: ML
authors.lastname: Couble
mesh_terms: D000328:Adult; D003094:Collagen / Q000032:analysis*; D005881:Gingiva / Q000032:analysis* / Q000166:cytology / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D010518:Periodontitis / Q000378:metabolism* / Q000473:pathology
chemical_list: D003094:Collagen