[Effects of the administration of ascorbic acid on 3-OAA-antigen levels formed during chemical hepatocarcinogenesis].
Variations in liver, blood and urine 3-oxyanthranilic acid-antigen (3-OAA-A) levels and those of ascorbic acid in liver of rats and mice receiving various hepatocarcinogens were examined. Treatment with ascorbic acid (three courses of 15 injections each) given prior to tumor development and during early carcinogenesis was followed by a significant decrease in 3-OAA-A concentration up to its complete elimination from the body and prevented hepatoma development.
Korosteleva
T A
TA
Shvaĭdetskiĭ
I I
II
Mishukov
V I
VI
D015095:3-Hydroxyanthranilic Acid; D000818:Animals; D000941:Antigens / Q000032:analysis* / Q000097:blood / Q000652:urine; D001205:Ascorbic Acid / Q000627:therapeutic use*; D008099:Liver / Q000032:analysis; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D051381:Rats; D062367:ortho-Aminobenzoates
D000941:Antigens; D062367:ortho-Aminobenzoates; D015095:3-Hydroxyanthranilic Acid; D001205:Ascorbic Acid
Vliianie vvedeniia askorbinovoĭ kisloty na dinamiku 3-OAK-antigenov, obrazuiushchikhsia v organizme pri khimicheskom gepatokantserogeneze.