Non-Hodgkin's lymphoma diagnosis aided by the S.A.M. system.
In the attempt to discriminate between centroblasts and immunoblasts, an analytical morphometrical procedure was adopted, considering the nuclei of a randomly selected centroblastic and immunoblastic population from non-Hodgkin's lymphomas and the nucleoli of a more restricted number of the same neoplastic population. All the size-independent shape-descriptor parameters extracted for each step of the mathematical analyses used were submitted to Hotelling's multivariate discriminant analysis that enabled us to achieve a good distinction (3% error) between centroblasts and immunoblasts when nuclear and nucleolar parameters were used together.
Ricco
R
R
Institute of Pathological Anatomy, Anthropology, University of Bari, Italy.
De Benedictis
G
G
Lettini
T
T
Pesce Delfino
V
V
Gentile
A
A
Pennella
A
A
Serio
G
G
D002467:Cell Nucleus / Q000473:pathology; D016002:Discriminant Analysis; D005583:Fourier Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology* / Q000648:ultrastructure; D014741:Video Recording