[Study of lymphocyte subpopulations by means of monoclonal antibodies in acute hepatitis A and B].
We studied T3, T4 and T8 lymphocyte populations in peripheral blood by monoclonal antibodies in 40 patients with acute viral hepatitis (Type A 20; Type B 20) who underwent outcome to complete recovery. We compared the results with 20 healthy subjects (control group). We found a decrease in total lymphocytes measured by T3 monoclonal antibodies and a significant increase in T8 lymphocyte populations compared with control groups. In the early stage the T4/T8 ratio was decreased. Lymphocyte populations and T4/T8 ratio was normal in 3-6 month follow-up for the acute A hepatitis group and 3.6 month to a year follow-up for the B hepatitis group. Results were related to the humoral and clinical outcome.
Collazo
L
L
Sotto
A
A
Morales
M G
MG
Borbolla
E
E
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000032:analysis*; D005260:Female; D006506:Hepatitis A / Q000097:blood*; D006509:Hepatitis B / Q000097:blood*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D013601:T-Lymphocytes / Q000032:analysis*
D000911:Antibodies, Monoclonal
Estudio de sub-poblaciones linfocitarias mediante anticuerpos monoclonales en hepatitis aguda A y B.