Purified equine rabies immune globulin: a safe and affordable alternative to human rabies immune globulin.
Reported are the results of a retrospective study of 3156 patients who were treated at the Queen Saovabha Memorial Institute, Bangkok, with equine rabies immune globulin (ERIG). Only 51 patients (1.6%) exhibited serum-sickness-like reactions, none of which persisted for more than a week, and only 8 of these patients (15%) were treated with a short course of steroids. One patient, whose skin test was negative, had an immediate anaphylactic reaction to ERIG that responded to parenteral therapy with epinephrine and hydrocortisone sodium succinate. Serum-sickness-like reactions were more frequent among females and over 21-year-olds but were exceedingly rare (0.086%) among children under 10 years of age.
Wilde
H
H
Chomchey
P
P
Punyaratabandhu
P
P
Phanupak
P
P
Chutivongse
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D002648:Child; D005260:Female; D006736:Horses / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011818:Rabies / Q000628:therapy*; D011819:Rabies Vaccines / Q000009:adverse effects / Q000627:therapeutic use*; D011820:Rabies virus / Q000276:immunology*; D012189:Retrospective Studies; D012713:Serum Sickness / Q000209:etiology
D011819:Rabies Vaccines