[Effect of hemodialysate and its peptide fractions on stromal cells and heme synthesis in bone marrow cultures and the activity of selected enzymes and GSH and in human erythrocytes. V. Effect on AChE activity in the erythrocytes of healthy persons and patients with terminal renal failure].
Effect of hemodialysate and its three peptide fractions on the acetylcholinesterase (AChE, E.C. 3.1.1.7) activity in erythrocytes from healthy subjects and patients with terminal renal insufficiency treated by repeated hemodialyses. It has been shown that erythrocytes from hemodialysed patients have statistically significantly increased activity of the enzyme if compared with that in healthy subjects. Both hemodialysate and its three peptide fractions after the 3 hours lasting incubation with erythrocytes from healthy subjects and from the patients induced no alteration in the enzyme activity except fraction III having incubative concentration 270 micrograms/ml calculated against the protein concentration. Fraction III exerted statistically significant inhibitory effect on the acetylcholinesterase activity in erythrocytes from healthy subjects.
Smoleński
O
O
D000110:Acetylcholinesterase / Q000097:blood*; D003470:Culture Media; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D066298:In Vitro Techniques; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D010446:Peptide Fragments / Q000494:pharmacology*; D012016:Reference Values; D006435:Renal Dialysis; D013727:Terminal Care
D003470:Culture Media; D010446:Peptide Fragments; D000110:Acetylcholinesterase
Wpływ hemodializatu i jego frakcji petydowych na komórki podścieliska i synteze hemu w hodowli szpiku oraz na aktywność wybranych enzymów i stezenie GSH w krwinkach czerwonych człowieka. Cześć V: Wpływ na aktywność AChE w erytrocytach ludzi zdrowych i chorych w schyłkowej niewydolności nerek.