Effects of methenamine on mouse lymphoma cells.
Methenamine, (hexamethylenetetramine H) is a well tolerated drug used in the therapy of E. coli or herpes virus induced diseases. It is detectable in blood for many hours. H behaves similarly to salicylic acid, which has been known just as long, and also has a variety of target points independent of each other. In acid pH medium a dissociation of toxic disintegration products is suggested. During the cell cycle the intracellular pH in many cellular compartments shows a wide variation. Caused by the disintegration products H inhibits the proliferation of L 5178 Y cells and decreases the cell volume and size of the nucleus. Thus in the eukaryotic cell H can be therapeutically important and therefore may prove successful not only against bacteria and viruses.
Reitz
M
M
Institute for Physiological Chemistry, University of Mainz, Fed. Rep. of Germany.
Jaeger
K H
KH
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D004273:DNA, Neoplasm / Q000032:analysis / Q000187:drug effects; D007940:Leukemia L5178 / Q000473:pathology*; D007942:Leukemia, Experimental / Q000473:pathology*; D008709:Methenamine / Q000494:pharmacology*; D051379:Mice; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D004273:DNA, Neoplasm; D008709:Methenamine; D002945:Cisplatin