Role of brown adipose tissue in glucose utilization in conscious pre-obese Zucker rats.
In 16-day-old conscious Zucker rats, at a time when pre-obese fa/fa rats were not yet hyperinsulinaemic compared with their lean Fa/fa littermates, the whole-body glucose-metabolism rate was decreased by 10% in pre-obese compared with lean pups. The markedly decreased glucose utilization found in brown adipose tissue (BAT) of pre-obese compared with lean pups accounted for at least 70% of the difference in whole-body glucose metabolism observed between the two genotypes. In pre-obese fa/fa rats, the 20% decrease in noradrenaline content of BAT reported in this study is consistent with the diminished glucose utilization by this tissue, and further supports the hypothesis of a defect in the sympathetic-nervous-system regulation of BAT metabolism as one of the primary causes for this genetic obesity.
Krief
S
S
Institut National de la Santé et de la Recherche Médicale, Unité 177, Paris, France.
Bazin
R
R
Dupuy
F
F
Lavau
M
M
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition; D003847:Deoxyglucose / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D007700:Kinetics; D009132:Muscles / Q000378:metabolism; D051381:Rats; D011924:Rats, Zucker
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D003847:Deoxyglucose