title: Spin-lock techniques and CPMG imaging sequences: a critical appraisal of T1p contrast at 0.15 T.
abstract: The addition of a spin-lock preparatory sequence to a Carr-Purcell-Meiboom-Gill (CPMG) imaging sequence provides a method which allows an accurate and simple comparison of T1p and T2 contrast. Sagittal and axial brain images, produced with the application of a three pulse preparatory spin-lock sequence prior to a sixteen-echo CPMG imaging sequence, are compared with images acquired without the spin-lock sequence. The CPMG sequence uses non-selective refocusing pulses. Therefore, observed echo signals accurately reflect T2 relaxation. This allows a convenient method for assessing the degree to which T1p and T2 contrast differ. The spin-lock CPMG (SL-CPMG) images were acquired with a spin-locking field amplitude of 0.4 G and resemble heavily T2-weighted images at 0.15 T. Quantitative analyses of signal intensities from edema and normal brain tissue confirm the qualitative observations. This in vivo method should prove useful for determining when the additional RF power deposition associated with spin-locking techniques will provide an alternate form of tissue contrast than that available from additional echo collection.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: R V
authors.initials: RV
authors.lastname: Mulkern
authors.forename: S
authors.initials: S
authors.lastname: Patz
authors.forename: M
authors.initials: M
authors.lastname: Brooks
authors.forename: D C
authors.initials: DC
authors.lastname: Metcalf
authors.forename: F A
authors.initials: FA
authors.lastname: Jolesz
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000175:diagnosis; D003287:Contrast Media; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*
chemical_list: D003287:Contrast Media