[The role of lipid peroxidation disorders in the pathogenesis of drug disease].
The stress syndrome reaction, blood serum spontaneous and induced super-weak fluorescence, intermediate and end products of lipid peroxidation (LPO), i. e. diene conjugates, malonic dialdehyde, hydroperoxides; and the antioxidant defense parameters, i.e. the blood serum alpha-tocopherol level, catalase and peroxidase activities were studied in 467 patients with drug disease. Normal LPO course was observed in the patients with drug disease developing in the presence of various somatic diseases. This is an evidence of the pathogenetic significance of LPO processes in the development of drug sensitization, which fact prompts the use of the aforesaid LPO and antioxidant defense characteristics for the early diagnosis of drug disease and for monitoring the treatment efficacy.
Soloshenko
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D000328:Adult; D000485:Allergens; D001769:Blood / Q000187:drug effects; D004342:Drug Hypersensitivity / Q000097:blood / Q000209:etiology*; D006801:Humans; D015227:Lipid Peroxidation; D008163:Luminescent Measurements; D008875:Middle Aged; D012394:Rosaniline Dyes; D012871:Skin Diseases / Q000097:blood / Q000139:chemically induced*; D013312:Stress, Physiological / Q000097:blood / Q000150:complications
D000485:Allergens; D012394:Rosaniline Dyes; C025485:basic fuchsin
Rol' narusheniia pereksinogo okisleniia lipidov v patogeneze lekarstvennoĭ bolezni.