title: Reversal of changes of lipid peroxide, xanthine oxidase and superoxide dismutase by cardio-protective drugs in isoproterenol induced myocardial necrosis in rats.
abstract: In myocardial necrosis produced by isoproterenol (beta-adrenergic agonist) marked increase in creatine phosphokinase, phospholipase and significant decrease in cardiac glycogen and phospholipid levels were observed. The enhanced levels of lipid peroxides, xanthine oxidase activity and lowering of superoxide dismutase may lead to excessive formation of free radicals resulting in cardiac cell damage. Nifedipine--a calcium antagonist, Propranolol--a beta-blocker and guggulsterone a lipid lowering agent showed marked reversal of these metabolic changes related to ischemia induced by isoproterenol.
authors.forename: S
authors.initials: S
authors.lastname: Kaul
authors.forename: N K
authors.initials: NK
authors.lastname: Kapoor
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000494:pharmacology*; D007545:Isoproterenol; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010088:Oxidoreductases / Q000378:metabolism*; D011282:Pregnenediones / Q000494:pharmacology; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D002317:Cardiovascular Agents; D008054:Lipid Peroxides; D011282:Pregnenediones; C023617:pregna-4,17-diene-3,16-dione; D010088:Oxidoreductases; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D007545:Isoproterenol