title: Pharmacokinetics of propofol in young children after a single dose.
abstract: The pharmacokinetics of propofol were studied following a single bolus injection (2.5 mg kg-1) in 10 healthy children (4-7 yr). Propofol was distributed rapidly and extensively (Vss 10.9 (1.2) litre kg-1) and cleared rapidly from the body (Cl 30.6 (2.9) ml min-1 kg-1). With the exception of a larger central compartment volume (V alpha 722 (113) ml kg-1), these data are similar to those reported for young adults who received an identical dose and who underwent sampling over the same period. The larger value of V alpha is consistent with the higher induction dose requirement reported for children.
authors.affiliation: Département d'Anesthésie-Réanimation, Hôpital Saint-Vincent-de-Paul, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Saint-Maurice
authors.forename: I D
authors.initials: ID
authors.lastname: Cockshott
authors.forename: E J
authors.initials: EJ
authors.lastname: Douglas
authors.forename: M O
authors.initials: MO
authors.lastname: Richard
authors.forename: J L
authors.initials: JL
authors.lastname: Harmey
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D015742:Propofol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D015742:Propofol