Effects of acute and chronic administration of two antibiotics, aztreonam and gentamicin, alone or in combination, on "open-field test" in mice.
A study aimed at investigating the behavioural effects of aztreonam and gentamicin, given separately or in combination, was carried out in mice. Animals were randomly assigned to two test conditions: acute and chronic treatment. Those receiving acute treatment had a single IP injection 60 min before the test. Those receiving chronic treatment had IP injections once daily for 5 successive days prior to the test. Behavioural patterns (ambulation, rearing, grooming and defecation) were assessed using the "open-field" test. The results indicate that, both after single and multiple dosing, aztreonam (10, 40 and 80 mg/kg IP) and/or gentamicin (10 mg/kg IP) do produce changes in the behaviour of animals. A rate increasing effect for certain behaviours (rearing, grooming and defecation) and a reduction in other behaviours (ambulation) seems to occur.
De Angelis
L
L
Istituto di Farmacologia, Università di Trieste, Italy.
D000818:Animals; D001398:Aztreonam / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D005839:Gentamicins / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D051379:Mice
D005839:Gentamicins; D001398:Aztreonam