Additive effect of the combination of griseofulvin and ketoconazole against Microsporum canis in vitro.
The susceptibility of 28 strains of Microsporum canis to griseofulvin, to ketoconazole and to a combination of both antifungal drugs was determined. Griseofulvin proved to be more active than ketoconazole. The combination of both antifungal agents was found to exert an additive effect.
Banic
S
S
Lunder
M
M
D004359:Drug Therapy, Combination; D006118:Griseofulvin / Q000494:pharmacology*; D007654:Ketoconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects* / Q000254:growth & development
D006118:Griseofulvin; D007654:Ketoconazole