An experimental study of mucociliary pathology of the eustachian tube in otitis media with effusion induced by irradiation.
We have examined the function and fine structure of the mucociliary system of the eustachian tube in an experimental study of otitis media with effusion induced by X-ray irradiation. Functional examination demonstrated that the ciliary activity was diminished in such a condition, while morphological observations showed pathological findings including compound cilia, vacuolation of ciliated cells and expansion of intercellular space. These findings show that irradiation-induced otitis media with effusion results in impairment of the mucociliary system. As evidenced by these studies, the mucociliary system in the eustachian tube has an important role in the clearance of fluid produced in the tympanic cavity as well as affording improvement in this disease.
Ohashi
Y
Y
Department of Otolaryngology, Osaka City University Medical School, Japan.
Nakai
Y
Y
Esaki
Y
Y
Onoyama
Y
Y
D000818:Animals; D002923:Cilia / Q000528:radiation effects / Q000648:ultrastructure; D005064:Eustachian Tube / Q000503:physiopathology* / Q000528:radiation effects / Q000648:ultrastructure; D006168:Guinea Pigs; D008855:Microscopy, Electron, Scanning; D010034:Otitis Media with Effusion / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D013997:Time Factors