[Radiation therapy with or without cisplatin in esophageal carcinoma].
Of 74 patients with an esophageal carcinoma, 26 were treated with a combined modality of radiotherapy and cisplatin (CDDP group), and 48 were treated with radiotherapy alone (RT group). Sixteen patients were salvaged by surgery after radiotherapy. Fifty-two patients were found to have a loco-regional disease (RT group: 34 patients; CDDP group: 18 patients) and 22 patients had a distant metastasis at the time of the initial treatment (RT group: 14 patients; CDDP group; 8 patients). For those with a loco-regional disease, the response rate was for those in the CDDP group and 34% for those in the RT group. For non-surgically salvaged cases, the median survival was 12 months and there was no statistically significant difference between the CDDP and the RT groups. For the surgically salvaged cases, 2 out of 7 patients in the RT group and 5 out of 9 patients an in the CDDP group are still alive. Additionally, four T3 cases were salvaged by surgery in the CDDP group.
Chatani
M
M
Dept. of Radiation Therapy, Center for Adult Diseases, Osaka.
Teshima
T
T
Inoue
T
T
D000368:Aged; D000369:Aged, 80 and over; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012074:Remission Induction
D002945:Cisplatin