Pyridazine analogues of biologically active compounds. Part 5: Novel potential cardiotonics of the amrinone type.
Preparation of a series of novel pyridazine derivatives structurally related to bipyridine cardiotonics, starting from 4-methylpyridazine or 4-acetylpyridazine, respectively, is described. As observed with compounds 8, 11 and 16, an enhancement of in vitro cardiotonic activity is associated with the replacement of one or both pyridine subunit(s) in amrinone or milrinone by a 1,2-diazine system.
Haider
N
N
Institute of Pharmaceutical Chemistry, University of Vienna, Austria.
Heinisch
G
G
Offenberger
S
S
D000676:Amrinone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D066298:In Vitro Techniques; D020105:Milrinone; D009200:Myocardial Contraction / Q000187:drug effects; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011728:Pyridones / Q000494:pharmacology
D002316:Cardiotonic Agents; D011724:Pyridazines; D011728:Pyridones; D020105:Milrinone; D000676:Amrinone