title: O-alkyl O-nucleoside 3'-phosphonates as novel starting materials for oligonucleotide synthesis.
abstract: It was found that the title compounds were activated rapidly into the corresponding highly reactive phosphorochloridites by use of tris(2,4,6-tribromophenoxy)dichloro-phosphorane (BDCP) as a chlorinating reagent. The reaction was applied to the synthesis of oligodeoxyribonucleotides.
authors.affiliation: Department of Life Chemistry, Tokyo Institute of Technology, Yokohama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Wada
authors.forename: R
authors.initials: R
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Hotoda
authors.forename: M
authors.initials: M
authors.lastname: Sekine
authors.forename: T
authors.initials: T
authors.lastname: Hata
mesh_terms: D007202:Indicators and Reagents; D009705:Nucleosides; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D063065:Organophosphonates; D009943:Organophosphorus Compounds
chemical_list: D007202:Indicators and Reagents; D009705:Nucleosides; D009838:Oligodeoxyribonucleotides; D063065:Organophosphonates; D009943:Organophosphorus Compounds; C060627:tris(2,4,6-tribromophenoxy)dichlorophosphorane