The effect of detomidine hydrochloride on the electrical activity of uterus in pregnant mares.
The effect of detomidine on the electrical activity of the uterus was studied during the last trimester of pregnancy in 6 mares. The effect was observed in 3-5 min after the i.m. injection and it lasted for 50-70 min. 20 and 40 micrograms/kg b.w. doses of detomidine decreased the myometrial electrical activity, whereas 60 micrograms/kg dose did not have any effect on the activity. The results suggested that 20, 40 and 60 micrograms/kg b.w. doses of detomidine can be administered to mares during the last trimester of pregnancy without the risk of abortion induced by increased uterine electrical activity.
Jedruch
J
J
Gajewski
Z
Z
Kuussaari
J
J
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004576:Electromyography / Q000662:veterinary; D005260:Female; D006736:Horses / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects* / Q000502:physiology
D000700:Analgesics; D006993:Hypnotics and Sedatives; D007093:Imidazoles; C041255:detomidine