Pulmonary artery counterpulsation to improve right ventricular function after heart transplantation.
The effectiveness of pulmonary artery counterpulsation in improving right ventricular function after heart transplantation was evaluated in a pig model. The balloon catheter was introduced through the anterior wall of the pulmonary artery distal to the pulmonary valve. A Millar catheter with a distal high-fidelity pressure transducer was placed in the right ventricle, where the peak rate of pressure rise, dP/dT, was measured. Pulmonary artery counterpulsation significantly improved right ventricular function, increasing both dP/dT and systolic pressure. A diastolic dip in pulmonary artery pressure and a fall in the early portion of the right ventricular pressure curve were seen. Inflation of the balloon caused a second (suprasystolic) wave in that curve. Improved right ventricular function was also seen when normal pig hearts were counterpulsated after occlusion of the right coronary artery and following increased afterload due to occlusion of a main pulmonary artery. There were no changes in central venous or systemic pressure. The results indicate that pulmonary artery counterpulsation may be valuable when the transplanted heart has a poorly functioning right ventricle.
Harjula
A L
AL
Department of Cardiovascular Surgery, Stanford University Medical Center, CA.
Baldwin
J C
JC
D000818:Animals; D002404:Catheterization; D015908:Counterpulsation; D005069:Evaluation Studies as Topic; D016027:Heart Transplantation; D006352:Heart Ventricles / Q000033:anatomy & histology; D011182:Postoperative Care / Q000379:methods*; D011651:Pulmonary Artery; D013552:Swine; D014184:Transplantation, Homologous; D016276:Ventricular Function