[The hemodynamics of the lung circulation of minipigs after experimentally-caused Sedlarik's pulmonary embolism. III. Sedlarik's embolization of the lung circulation by electrically-activated blood].
Pulmonary embolisms of different clinical degree of severity can be produced by means of the pulmonary embolism model according to Sedlarik by application of electrically activated blood as a thrombogenic substance. An unambiguous influence of the size and the consistency of the thrombus exists concerning the severity of the hemodynamic changes. However, the hemodynamics seems to adapt to the changed conditions of the circulation, because a tendency to normalization was observed in short-term experiments. The morphologic changes after embolisation are more typical for the severity of the clinical picture in this acute phase than the hemodynamics. A testing of the animal model in long-term experiments seem to be ingenious for that reason.
Lesser
T
T
Ebner
E
E
Riedel
E
E
Zwiener
U
U
Runkewitz
V
V
D000818:Animals; D001794:Blood Pressure; D002496:Central Venous Pressure; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000009:adverse effects; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics; D008168:Lung / Q000473:pathology; D008297:Male; D011652:Pulmonary Circulation; D011655:Pulmonary Embolism / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D011669:Pulmonary Wedge Pressure; D013552:Swine; D013556:Swine, Miniature
Zur Hämodynamik des Lungenkreislaufes de Minischweins nach experimentell ausgelöster Lungenembolie nach Sedlarik. III. Embolisierung der Lungenstrombahn mit elektrisch aktiviertem Blut nach Sedlarik.