[Organic changes in rabbits and rats in phosphorothioaliphatic compound poisoning. III. The histomorphologic picture of selected internal organs, especially the myocardium, in rats and rabbits in phosphorothioaliphatic pound poisoning treated with oximes].
Pathomorphological changes of the cardiac muscle of experimental rabbits and rats intoxicated with Intration were traced. Diffuse ischaemic lesions such as the presence of large quantities of mitochondria, contraction nodes and droplet necrosis were observed. These lesions result: from the toxic effect of pesticides on myocytes and inhibition of cholinesterases as well as from nonphysiologically great activity of lysosome enzymex which are also responsible for necrotic lesions in the cardiac muscle. Excessively high PAM doses administered to animals intoxicated with pesticide result in lesions in the cardiac muscle of rabbits and rats which are greater than after administering an insectide alone. Toxobidin, a multi-function compound, doses not possess such negative properties as PAM.
Giermaziak
H
H
Ze Szpitala WUSW w Lodzi.
D000818:Animals; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D004719:Endomyocardial Fibrosis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D062025:Organophosphate Poisoning; D063086:Organothiophosphates / Q000037:antagonists & inhibitors; D009946:Organothiophosphorus Compounds / Q000506:poisoning*; D010091:Oximes / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D007306:Insecticides; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; D010091:Oximes; C100178:thiometon
Zmiany narzadowe u królików i szczurów w przebiegu zatrucia zwiazkiem fosforotioalifatycznym. Cześć III. Obraz histomorfologiczny wybranych narzadów wewnetrznych, a zwłaszcza mieśnia sercowego królików i szczurów w przebiegu zatrucia zfo i leczenia oksymami.