The effect of methotrexate on the development of synapses in the neonatal rat hippocampus.
The effects of postnatal methotrexate (MTX) exposure on the development of synapses in the developing rat hippocampus were examined. The density of E-PTA-stained synaptic junctions per unit area was significantly reduced by MTX exposure either during day 1-5 or 6-10 post partum. It was suggested that administering MTX during the critical period affected the development of synapses in the developing rat brain.
Igarashi
H
H
Second Department of Anatomy, Toho University School of Medicine, Tokyo, Japan.
Inomata
K
K
Tateno
A
A
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000254:growth & development* / Q000648:ultrastructure; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000187:drug effects* / Q000648:ultrastructure
D008727:Methotrexate