title: Measurement of the villus surface area and its regional variation in the human full-term placenta.
abstract: The surface/volume ratio and the surface density of the chorionic villi in different cotyledonary regions of the human mature placenta were studied by stereologic methods. The villus surface/volume ratio showed a mean value of 812.3 cm2/cm3 (standard deviation = 89.2 cm2/cm3). There were no significant differences according to the site from which the sample was obtained. The villus surface density in normal mature placentae was (496.3 +/- 49.0) cm2/cm3. The last parameter showed no differences among regions. Despite the absence of significant differences of exchange surface areas among the cotyledonary regions considered, other important parameters, such as trophoblast thickness, frequency of vasculo-syncytial membranes, as well as the maximal gradient of concentration, facilitates the maternal-fetal transfer by simple diffusion mechanism in the central-parabasal region.
authors.affiliation: Department of Gynecology and Obstetrics, School of Medicine of Ribeirão Preto, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Matheus
authors.forename: M A
authors.initials: MA
authors.lastname: Sala
mesh_terms: D002824:Chorionic Villi / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000033:anatomy & histology*; D011247:Pregnancy