Effects of rifampin treatment on contact sensitivity reactions to oxazolone in Balb/C mice.
Treatment of mice with rifampin (Ri, 100-200 mg/kg) affected the course of contact sensitivity (CS) reactions to oxazolone. The effects which were seen as either partial inhibition or enhancement of the response, under one set of conditions, could be abrogated or even reversed if conditions of either induction, elicitation and time of measuring reactions were altered. In addition, amount of Ri used for treatment and time of treatment in relation to the induction of CS reactions also influenced the effects observed.
Liakopoulou
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Health and Welfare Canada, Drug Research Laboratories, Ottawa.
D000818:Animals; D003877:Dermatitis, Contact / Q000188:drug therapy* / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010081:Oxazolone / Q000009:adverse effects; D012293:Rifampin / Q000627:therapeutic use*; D013997:Time Factors
D010081:Oxazolone; D012293:Rifampin