[Intra-arterial infusion therapy of progressive diabetic foot gangrene with prostaglandin E1 amd cefotaxime].
15 patients with severe diabetic gangrene were treated with a combined intra-arterial PGE1/Cefotaxime infusion therapy. There was no indication for vascular reconstructive surgery. The average treatment took 24.7 days. 11 of the 15 patients were responsive to the therapy. Nevertheless 5 of these 11 patients had to be amputated below-knee in the further course of treatment. In 6 cases we succeeded in preserving the affected extremity in a state of acceptable use. One patient died during the study. No complications due to the therapy were seen. Considering that all patients were near to amputation when entering the study the result to have saved the extremities in 40% of the cases must be regarded as a success.
Krawzak
H W
HW
Jäkel
F
F
Strosche
H
H
Buchholz
J
J
D000527:Alprostadil / Q000008:administration & dosage / Q000627:therapeutic use*; D002439:Cefotaxime / Q000008:administration & dosage / Q000627:therapeutic use*; D003925:Diabetic Angiopathies / Q000188:drug therapy*; D005528:Foot / Q000473:pathology*; D005534:Foot Diseases / Q000188:drug therapy*; D005734:Gangrene; D006801:Humans; D007261:Infusions, Intra-Arterial
D000527:Alprostadil; D002439:Cefotaxime
Intraarterielle Infusionstherapie der fortgeschrittenen diabetischen Fussgangrän mit Prostaglandin E1 und Cefotaxim.