Erythromycin A oxime 11,12-carbonate and its oxime ethers.
Erythromycin A oxime 11,12-carbonate (5a) and its oxime ethers 5b approximately 5p have been prepared and their antibacterial activities compared with those of erythromycin A (1) and its 11,12-carbonate 2. The oxime 5a and many of its oxime ether derivatives showed good activity in vitro against Gram-positive and the more permeable Gram-negative organisms, in some cases being even more active than the carbonate 2.
Brain
E G
EG
Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Surrey, UK.
Forrest
A K
AK
Hunt
E
E
Shillingford
C
C
Wilson
J M
JM
D055598:Chemical Phenomena; D002621:Chemistry; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004987:Ethers / Q000138:chemical synthesis* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology
D004987:Ethers; D010091:Oximes; C063102:erythromycin A oxime 11,12-carbonate; D004917:Erythromycin