title: Enzyme activity and distribution of adenosine deaminase types in a population of central Italy.
abstract: Blood samples from 718 unrelated individuals born in municipalities of the 'Alto Maceratese' region in central Italy were examined for adenosine deaminase (ADA). The allele frequencies for ADA*1 and ADA*2 were 92.48 and 7.45%, respectively. One case of the rare ADA 5-1 phenotype was observed. The observed phenotype distribution agreed well with the one expected assuming a Hardy-Weinberg equilibrium. Enzyme activity was measured in red blood cells from individuals with different phenotypes. The relationships between the enzyme activity of the phenotypes was found to be ADA 1 greater than ADA 2-1 greater than ADA 2 greater than ADA 5-1.
authors.affiliation: Department of Cell Biology, University of Camerino (MC), Italy.
authors.forename: N
authors.initials: N
authors.lastname: Lucarini
authors.forename: P
authors.initials: P
authors.lastname: Borgiani
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood / Q000235:genetics*; D004592:Electrophoresis, Starch Gel; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007558:Italy; D008297:Male; D009700:Nucleoside Deaminases / Q000235:genetics*; D010641:Phenotype
chemical_list: D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase