title: A screening method using tissue culture for evaluation of potential retinal adhesives.
abstract: Several adhesives have been tested for their potentially toxic effects on embryonic retinal tissue. The authors have characterized the effects of the adhesives on neurofilament extension and also on surgical-wound "re-knitting." While none of the adhesives in the sample (including those in current surgical use) seem to be ideal, the model advanced has application for the continuing development of better 'bio-adhesives'. The most immediate application is within the field of vitreoretinal surgery in situations where conventional procedures currently seem inadequate.
authors.affiliation: Neuropsychiatry Branch, National Institute of Mental Health, Washington, DC.
authors.forename: M J
authors.initials: MJ
authors.lastname: Jaffe
authors.forename: A P
authors.initials: AP
authors.lastname: Oliver
authors.forename: M A
authors.initials: MA
authors.lastname: Von Fricken
authors.forename: L
authors.initials: L
authors.lastname: Silberstein
authors.forename: R J
authors.initials: RJ
authors.lastname: Wyatt
mesh_terms: D000818:Animals; D003094:Collagen / Q000633:toxicity; D046508:Culture Techniques; D004338:Drug Combinations / Q000633:toxicity; D004659:Enbucrilate / Q000633:toxicity; D005340:Fibrinogen / Q000633:toxicity; D007797:Laminin / Q000633:toxicity; D008565:Membrane Proteins / Q000633:toxicity; D008722:Methods; D011509:Proteoglycans / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000187:drug effects*; D014014:Tissue Adhesives / Q000633:toxicity*
chemical_list: C056580:Cell-Tak; D004338:Drug Combinations; D007797:Laminin; D008565:Membrane Proteins; D011509:Proteoglycans; D014014:Tissue Adhesives; C059485:matrigel; D005340:Fibrinogen; D003094:Collagen; D004659:Enbucrilate