Evaluation of the teratogenic potential of the rubber accelerator dibenzthiazyl disulphide in rats.
The teratogenic potential of dibenzthiazyl disulphide (MBTS) was studied in Wistar rats. Pregnant rats were given MBTS at a dosage of 0, 0.04, 0.2 or 1% in the diet from day 0 to day 20 of pregnancy. Daily intakes of MBTS were 26 mg kg-1 for the 0.04% group, 127 mg kg-1 for the 0.2% group and 596 mg kg-1 for the 1% group. Maternal body weight gain during day 0 to day 14 of pregnancy in the 1% group was significantly lowered, but no significant changes induced by MBTS were observed in any other maternal parameters, such as food consumption and clinical sign of toxicity. There were no significant compound-related effects on the incidences of pre- and postimplantation losses and the number, sex ratio and body weight of live fetuses. Morphological examinations of the fetuses revealed no evidence of teratogenesis. In the postnatal development of the offspring from the dams given MBTS, a high survival rate and good growth of the offspring were seen. It could be concluded that MBTS possesses no adverse effects on the pre- and postnatal development of the offspring in rats at the doses employed in the present study.
Ema
M
M
National Institute of Hygienic Sciences, Osaka Branch, Japan.
Sakamoto
J
J
Murai
T
T
Kawasaki
H
H
D000818:Animals; D052160:Benzothiazoles; D004032:Diet; D005260:Female; D005333:Fetus / Q000187:drug effects; D008297:Male; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects; D012408:Rubber; D013723:Teratogens; D013844:Thiazoles / Q000633:toxicity*
D052160:Benzothiazoles; D013723:Teratogens; D013844:Thiazoles; C028000:dibenzothiazyl disulfide; D012408:Rubber