Antibacterial, antifungal and antitumoral activities of 5-carbamoyloxy and 5-acyloxynaphthalene-1,8-carbolactones.
Naphthalene-1,8 carbolactone derivatives have been investigated in order to compare their activities using antitumoral, antibacterial and antifungal tests in vitro. The effect of 5-substitution is the reduction of the toxicity and the suppression of the antibiotic activity. The best results were obtained with the ester series (5-acetoxy and 5-propionyloxy) on both antitumoral and antifungal tests.
Steiman
R
R
Laboratoire de Botanique, Cryptogamie, Biologie Cellulaire et Génétique, Faculté de Pharmacie, Meylan, France.
Berlion
M
M
Seigle-Murandi
F
F
Bériel
H
H
Fillion
H
H
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis*; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002219:Carbamates / Q000138:chemical synthesis / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002999:Clone Cells; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D002219:Carbamates; D007783:Lactones; D009281:Naphthalenes