Immunohistochemical analysis of accelerated graft atherosclerosis in cardiac transplantation.
HHT was performed between minimally genetic mismatched inbred strains of rats. There was no evidence of rejection and immunosuppressive therapy was not instituted. Immunohistochemical analysis using peroxidase conjugated monoclonal anti-rat ASMA of cardiac arterioles in which AGAS developed revealed a decreased peroxidase signal. The data suggest that modulation of actin expression in subintimal cells of cardiac arterioles may play a critical role in the pathologic development of AGAS.
Louie
H W
HW
Pang
M
M
Lewis
W
W
Drinkwater
D C
DC
Laks
H
H
D000818:Animals; D001160:Arterioles / Q000473:pathology; D003324:Coronary Artery Disease / Q000209:etiology* / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology; D016027:Heart Transplantation; D007150:Immunohistochemistry; D009131:Muscle, Smooth, Vascular / Q000276:immunology / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D011183:Postoperative Complications / Q000209:etiology* / Q000473:pathology; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D016042:Transplantation, Heterotopic; D014654:Vascular Patency