title: [A computer program for the drug dosage of patients with chronic kidney failure].
abstract: On the basis of the formula Mt = Mo.e-(Cl/Vd).t, a computer program was developed for estimating the maintenance drug dose in patients with chronic renal failure, depending on the creatinine clearance levels and the body mass. The hypothesis of the intact nephron and the presumption that in chronic renal failure the extrarenal clearance of the drugs does not change is considered a precondition. Any drug whose distribution volume and extrarenal clearance are known may be implicated in the program. The program may also help to determine the additional dose after hemodialysis, depending on the duration of the dialysis and the dialysis clearance of the drug.
authors.forename: S
authors.initials: S
authors.lastname: Krivoshiev
authors.forename: Zh
authors.initials: Zh
authors.lastname: Kalaĭdzhiev
authors.forename: S
authors.initials: S
authors.lastname: Antonov
authors.forename: S
authors.initials: S
authors.lastname: Zlatarska
authors.forename: Z
authors.initials: Z
authors.lastname: Kiriakov
mesh_terms: D003131:Combined Modality Therapy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000378:metabolism; D008657:Metabolic Clearance Rate; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010599:Pharmacokinetics; D006435:Renal Dialysis; D012984:Software
chemical_list: D004364:Pharmaceutical Preparations
vernacular_title: Kompiutŭrna programa za dozirane na medikamenti pri bolni s khronichna bŭbrechna nedostatŭchnost.