title: Inhibition of acetylcholinesterase by diastereomers of 2-methylamino-1-phenylpropanol and their derivatives.
abstract: The anti-acetylcholinesterase activities of the ephedrine diastereomers and their N-methyl derivatives were correlated to the conformation of the molecules in solution. The stereospecificity exhibited by enantiomers of N-methyl-psi-ephedrine was attributed to the predominance of one preferred conformation. The possibility of predicting the absolute configuration of chiral inhibitors from enzyme inhibitions data is discussed.
authors.forename: T L
authors.initials: TL
authors.lastname: Ngiam
authors.forename: M L
authors.initials: ML
authors.lastname: Go
mesh_terms: D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004809:Ephedrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D004809:Ephedrine