Production of thermozymocidin (myriocin) by the pyrenomycete Melanconis flavovirens.
Submerged culture of the pyrenomycete Melanconis flavovirens produces a strongly active antifungal antibiotic. The antibiotic was isolated from the culture mash. In purified compound the physico-chemical characteristics, including 1H NMR spectrum, were estimated. The antibiotic was found to be identical with thermozymocidin (myriocin) as confirmed by comparison with synthetically prepared thermozymocidin.
Sasek
V
V
Institute of Microbiology, Czechoslovak Academy of Sciences, Prague.
Sailer
M
M
Vokoun
J
J
Musílek
V
V
D000605:Amino Alcohols / Q000032:analysis / Q000138:chemical synthesis / Q000302:isolation & purification; D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis* / Q000138:chemical synthesis / Q000302:isolation & purification; D001203:Ascomycota / Q000254:growth & development / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D005229:Fatty Acids, Monounsaturated; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013696:Temperature
D000605:Amino Alcohols; D000935:Antifungal Agents; D005229:Fatty Acids, Monounsaturated; C001996:thermozymocidin