Leukoencephalopathy after cisplatin therapy.
Cisplatin is a neurotoxic chemotherapeutic agent known to cause sensory peripheral neuropathy or ototoxicity. We report a patient with an oropharynx carcinoma who developed a multifocal, necrotizing leukoencephalopathy after cisplatin treatment. This indicates that cisplatin can induce, similar to other chemotherapeutic agents, demyelinating, necrotizing lesions in the white matter of the cerebrum.
Brück
W
W
Department of Neuropathology, University of Göttingen, FRG.
Heise
E
E
Friede
R L
RL
D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002945:Cisplatin / Q000009:adverse effects*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged; D009336:Necrosis; D009778:Occipital Lobe / Q000473:pathology; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy; D010296:Parietal Lobe / Q000473:pathology
D002945:Cisplatin