title: [Prediction of the degree of nocturnal oxygen desaturation in sleep apnea syndrome by estimating the testosterone level].
abstract: We studied the influence of hypoxia due to sleep apnea on testosterone (T) secretion. It was conducted on the basis of an idea that sustained hypoxia may depress T secretion. The subjects consisted of 15 male patients with no drug administration whose complaints were snoring and/or obesity. The subjects participated in a sleep study on two consecutive nights. During the first night we collected blood samples starting every 4 hours from 10 PM via a catheter and measured T. From the data of the second night, we calculated total desaturation time with more than 4% from the baseline SaO2. According to the amount of this desaturation time, the subjects were divided into 2 groups; desaturation time less than 80 min in group 1 and longer in group 2, respectively. The peak value was seen at 6 AM in group 1 and at 10 AM in group 2. We investigated the correlation between the ratio of T10/T6, which is the ratio of T level at 10 AM to that at 6 AM, and parameters of sleep disorders related to oxygen desaturation. Total 4% desaturation time in total sleep period and non REM period significantly correlated with this ratio. From the diagram illustrating the correlation between the ratio and total 4% desaturation time in total sleep period, we could assume that if the ratio is beyond 1, the subject may have had more than about 80 min of total 4% desaturation time.
authors.forename: S
authors.initials: S
authors.lastname: Kouchiyama
authors.forename: S
authors.initials: S
authors.lastname: Masuyama
authors.forename: T
authors.initials: T
authors.lastname: Shinozaki
authors.forename: T
authors.initials: T
authors.lastname: Kurono
authors.forename: T
authors.initials: T
authors.lastname: Sakuma
authors.forename: K
authors.initials: K
authors.lastname: Tastumi
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: S
authors.initials: S
authors.lastname: Honda
authors.forename: T
authors.initials: T
authors.lastname: Kuriyama
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D012891:Sleep Apnea Syndromes / Q000097:blood*; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone; D010100:Oxygen