[The effect of thymoptin on enzymatic fibrinolysis].
Stimulation of fibrinolysis, decrease in content of fibrinogen and inhibitors were observed after intravenous, intramuscular or subcutaneous administrations of thymoptine preparation (complex of peptides, isolated from mammalian thymus) at doses of 0.1 microgram, 1.0 microgram/200 g of rat body mass. A more long-term effect was found after a course of treatment involving 5 subcutaneous or intramuscular injections (1.0 microgram). Single intravenous administration of thymoptine (0.1 microgram/200 g) caused a moderate thrombolytic action. Development of thrombosis, provoked by subtotal dose of thrombin, was inhibited after subcutaneous injection of the preparation.
Andreenko
G V
GV
Ashmarin
I P
IP
Zazhireĭ
V D
VD
Livshits
V A
VA
Serebriakova
T N
TN
Podorol'skaia
L V
LV
D000818:Animals; D001780:Blood Coagulation Tests; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis / Q000187:drug effects*; D010960:Plasminogen Activators / Q000097:blood; D051381:Rats; D013927:Thrombosis / Q000517:prevention & control; D013949:Thymus Extracts / Q000494:pharmacology*
D013949:Thymus Extracts; D005340:Fibrinogen; D010960:Plasminogen Activators
Vliianie timoptina na protsess fermentativnogo fibrinoliza.