title: Synergism between ciprofloxacin and fosfomycin against gram-negative bacteria in vitro.
abstract: A combination of ciprofloxacin and fosfomycin was evaluated for synergism employing time-kill experiments. A total of 59 clinical isolates of gram-negative bacteria was examined. All organisms were moderately sensitive or resistant to ciprofloxacin; 72.9% also showed moderate sensitivity or resistance to fosfomycin. After 24 h, synergism was seen in 22% of the strains, i.e. less than reported by other authors. There was no correlation between synergistic action and sensitivity to ciprofloxacin and fosfomycin, respectively.
authors.affiliation: Institut für Medizinische Mikrobiologie der Freien Universität, Berlin.
authors.forename: K
authors.initials: K
authors.lastname: Vogt
authors.forename: H
authors.initials: H
authors.lastname: Hahn
mesh_terms: D002939:Ciprofloxacin / Q000494:pharmacology*; D004357:Drug Synergism; D005578:Fosfomycin / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans
chemical_list: D005578:Fosfomycin; D002939:Ciprofloxacin