Disseminated Geotrichum capitatum infection in a patient with acute myeloid leukemia.
A case of invasive Geotrichum capitatum infection is reported; a young patient had an acute leukemia for which he received a chemotherapy, and presented sepsis with blood cultures for Geotrichum capitatum, namely Dipodascus spicifer; this pathogen only described in cactus rot, is responsible for the first case of a human disseminated infection reported in literature. Then he developed a splenic and epididymic infection, with positive cultures for Geotrichum capitatum after splenectomy and castration. Treatment with amphotericin B and itraconazole was started with low minimal inhibitory concentration (0.1 microgram/ml). The patient died of massive hemoptisis. Autopsy findings demonstrated a lung, brain and kidneys seeding.
Mahul
P
P
Piens
M A
MA
Guyotat
D
D
Godard
J
J
Archimbaud
E
E
Bui-Xuan
B
B
Motin
J
J
D000328:Adult; D005847:Geotrichosis / Q000209:etiology*; D006801:Humans; D007108:Immune Tolerance; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008297:Male; D009181:Mycoses / Q000209:etiology*