title: Changes of blood flow in the adenohypophysis of normal and estrogen pretreated Fisher rats by tamoxifen.
abstract: Blood flow was measured in the adenohypophysis and in the cerebral cortex of female F344 rats over a period of 90 min using the hydrogen clearance method. Tamoxifen, 1 mg/kg, administered iv reduced the blood flow in the adenohypophysis by 35%, whereas cerebral blood flow and arterial pressure remained unchanged. Seven days sc treatment with tamoxifen (1 mg/kg daily) had no demonstrable effect on blood flow. Anterior pituitary hyperplasia was induced in 15 rats with diethylstilbestrol containing implants. These rats responded to 7 days of sc tamoxifen treatment by 30% increase in adenohypophyseal blood flow. These results suggest that tamoxifen has a different effect on adenohypophysial circulation of the rat depending on whether it is administered in a low- or high-estrogen state.
authors.affiliation: Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, England.
authors.forename: A
authors.initials: A
authors.lastname: Stawowy
authors.forename: A A
authors.initials: AA
authors.lastname: Kemeny
authors.forename: J
authors.initials: J
authors.lastname: Jakubowski
mesh_terms: D000818:Animals; D004054:Diethylstilbestrol / Q000008:administration & dosage*; D005260:Female; D006965:Hyperplasia; D007279:Injections, Subcutaneous; D010903:Pituitary Gland, Anterior / Q000098:blood supply* / Q000473:pathology; D051381:Rats; D011916:Rats, Inbred F344; D012039:Regional Blood Flow / Q000187:drug effects; D013629:Tamoxifen / Q000008:administration & dosage*
chemical_list: D013629:Tamoxifen; D004054:Diethylstilbestrol