The sennoside constituents of rhei rhizoma and sennae folium as inhibitors of serum monoamine oxidase.
Four (in total) compounds with inhibitory effects on the activity of bovine serum monoamine oxidase were isolated from the methanol-water extracts of Rhei Rhizoma (Daiou) and Sennae Folium (Senna), and identified as sennosides A, B, E and F. Among them, sennosides A and B were obtained from both Rhei Rhizoma and Sennae Folium, while sennosides E and F were detected only in the former. The 50% inhibitory concentrations of the four sennosides were 17, 9, 24 and 13 microM, respectively, and the type of inhibition by seenosides A and B with respect to allylamine as the substrate was non-competitive.
Hiraoka
A
A
Koike
S
S
Sakaguchi
S
S
Masuda
Y
Y
Terai
F
F
Miura
I
I
Kawasaki
T
T
Kawai
H
H
Sakakibara
M
M
D000880:Anthraquinones / Q000032:analysis / Q000494:pharmacology*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000032:analysis*; D012676:Senna Extract; D000081226:Sennosides
D000880:Anthraquinones; D008996:Monoamine Oxidase Inhibitors; D000081226:Sennosides; D012676:Senna Extract