title: [The pharmacokinetics of hypolipemic agents. 6. Is 2-(4-(2,2-dichlorocyclopropyl)-phenoxy)-propane a metabolite of the hypolipemic ciprofibrate?].
abstract: According to earlier investigations 2-(4-(2,2-dichlorocyclopropyl)-phenoxy)-propane (4) ought to be a metabolite of the hypolipidemic agent ciprofibrate (1). However, 4 could not be detected in plasma or in urine after administration of a dose of 2100 mg 1 during the course of a multiple-dose-study. Therefore, the compound described in literature must be an unknown one and the existence of 4 as a metabolite of 1 is excluded.
authors.forename: H
authors.initials: H
authors.lastname: Oelschläger
authors.forename: D
authors.initials: D
authors.lastname: Rothley
authors.forename: K H
authors.initials: KH
authors.lastname: Hellwich
authors.forename: W
authors.initials: W
authors.lastname: Schmidt
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002994:Clofibrate / Q000031:analogs & derivatives*; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D058607:Fibric Acids; D006801:Humans; D000960:Hypolipidemic Agents / Q000493:pharmacokinetics*
chemical_list: D058607:Fibric Acids; D000960:Hypolipidemic Agents; C062987:2-(4-(2,2-dichlorocyclopropyl)phenoxy)propane; D002995:Clofibric Acid; C019304:ciprofibrate; D002994:Clofibrate
vernacular_title: Zur Pharmakokinetik von Lipidsenkern, 6. Mitt.: Ist 2-(4-(2,2-Dichlorcyclopropyl)-phenoxy)-propan ein Metabolit des Lipidsenkers Ciprofibrat?