title: [New aspects of the pathogenesis and treatment of Schulmann's eosinophilic fasciitis].
abstract: A female patient, aged 64, was admitted to hospital with a tentative diagnosis of dermatomyositis or systemic scleroderma. Basing on the clinical symptoms and histologic findings in examination of a musculocutaneofascial biopsy specimen from the focus of involvement on the left thigh, Schulmann's eosinophilic fasciitis was diagnosed. The mechanism of the disease is polypathogenic, it includes newly detected disorders of the blood rheology, of the enzymic and electrolyte metabolism, of the immunologic homeostasis at the cellular (E0-RFC) and humoral (IgE) levels, of the peripheral skin analyzer function, of the orocaudal relationships, and of the microcirculation. Treatment with enzymic, vasoactive, and immunocorrective drugs combined with D-penicillamine and He-Ne laser therapy has yielded a good clinical effect without resorting to glucocorticoids; the time of the treatment was reduced to 28 days. A stable clinical remission for 1.5 years was achieved.
authors.forename: V M
authors.initials: VM
authors.lastname: Kovalev
authors.forename: Z F
authors.initials: ZF
authors.lastname: Krivenko
mesh_terms: D003131:Combined Modality Therapy / Q000379:methods; D004802:Eosinophilia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005208:Fasciitis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D013577:Syndrome
vernacular_title: Novye aspekty patogeneza i lecheniia éozinofil'nogo fastsiita Shul'mana.