Protective effect of taurine against ammonia-induced gastric mucosal lesions in rats.
We examined the role of gastric ammonia in the development of gastric lesions in rats. Exposure of the gastric mucosa to ammonia (30 mM) produced microscopic injury, but no macroscopic lesion was observed. However, exposure of the stomach to ammonia in rats subjected to ischemia resulted in macroscopic gastric lesions. The macroscopic lesions were markedly inhibited by pretreatment with taurine, a scavenger of hypochlorous acid (HOCI) and monochloramine (NH2Cl). These results indicate that ammonia is deleterious to gastric mucosa, and monochloramine may be involved in the pathogenesis of ammonia-induced mucosal lesions.
Murakami
M
M
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Japan.
Yoo
J K
JK
Teramura
S
S
Yamamoto
K
K
Saita
H
H
Kita
T
T
Miyake
T
T
D000641:Ammonia; D000818:Animals; D000897:Anti-Ulcer Agents; D005753:Gastric Mucosa / Q000187:drug effects*; D007511:Ischemia / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D013654:Taurine / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D013654:Taurine; D000641:Ammonia