Excision repair differences in rat fibroblasts.
By using a cellular transformation system, which has been developed by Graffi et al., we analysed differences in the excision capacity of UV-induced dimers in normal cells, in vitro transformed cells and in malignant cells derived from a rat fibrosarcoma. The results suggest that both the transformed and the tumour-derived cells exhibit a kinetic pattern of excision repair different from that of the normal cells. Recognition of the dimers and the incision rate are more complete in the normal cell.
Klaus
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H
Central Institute for Cancer Research, Academy of Sciences of the GDR, Berlin-Buch.
Abel
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H
D000818:Animals; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004247:DNA / Q000528:radiation effects; D004260:DNA Repair; D005347:Fibroblasts / Q000528:radiation effects; D005354:Fibrosarcoma / Q000235:genetics; D007700:Kinetics; D051381:Rats; D014407:Tumor Cells, Cultured; D014466:Ultraviolet Rays
D004247:DNA