[The functional organization of autoregulation of local cerebral blood flow in spontaneously hypertensive rats in ontogeny].
The autoregulation of local cerebral blood flow in the cortex of 5, 8-10-, 16-20- and 46-50-week old spontaneously hypertensive rats involved responses to raising or lowering systemic blood pressure, reflecting an interaction among myogenic, neurogenic and metabolic mechanisms. In formation and stabilization of spontaneous hypertension, a reorganization of the autoregulation of local cerebral blood flow depending upon the level of blood pressure, occurred. The myogenic component seems to play a major role in the mechanisms of maintenance of constant blood supply in micro-areas of the brain in acute shifts of the blood pressure in spontaneously hypertensive rats.
Khananashvili
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IaA
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000375:Aging / Q000502:physiology*; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001795:Blood Pressure Determination / Q000379:methods; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D004567:Electrodes, Implanted; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology*; D006973:Hypertension / Q000503:physiopathology; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D011921:Rats, Inbred WKY
D000804:Angiotensin II; D000255:Adenosine Triphosphate
Funktsional'naia organizatsiia protsessa autoreguliatsii mestnogo mozgovogo krovotoka u spontanno gipertenzivnykh krys v ontogeneze.