Arachidonic acid-induced bronchomotor responses are partially mediated by release of sensory neuropeptides from capsaicin-sensitive structures.
Administration of arachidonic acid (AA) both in vitro and in vivo elicited prominent contractile responses in guinea-pig airways, which were markedly reduced after capsaicin desensitization. Furthermore, AA superfusion elicited a significant calcitonin gene-related peptide-like immunoreactivity release from isolated bronchi. It is suggested that at least part of the bronchomotor actions of AA rely upon stimulation of capsaicin-sensitive primary afferents.
Manzini
S
S
Istituto Farmacobiologico MALESCI, Pharmacology Department, Florence, Italy.
Ballati
L
L
Geppetti
P
P
Rubini
I
I
Meini
S
S
Perretti
F
F
D000758:Anesthesia; D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology; D002211:Capsaicin / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009479:Neuropeptides / Q000378:metabolism*
D001095:Arachidonic Acids; D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin