A multifactorial study (cell kinetics, cytogenetics, DNA content) of lung tumours: basic information for prognostic evaluation.
Different prognostic parameters (labeling index, chromosomal pattern, DNA content) were studied in 32 cases of lung tumour. A great variability was observed in the proliferative activity and karyotype, and there was a lack of correlation between these parameters and the histologic type. It was possible to demonstrate that a diploid DNA content does not necessarily correspond to a normal karyotype. A more precise evaluation of the prognostic significance of data obtained will be possible in correlation with an extensive follow-up of the patients studied.
Matturri
L
L
Institute of Pathological Anatomy, University of Milan, Italy.
Lavezzi
A M
AM
D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics* / Q000648:ultrastructure; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics* / Q000648:ultrastructure; D015984:Causality; D002455:Cell Division; D002875:Chromosomes / Q000032:analysis; D004247:DNA / Q000032:analysis; D005069:Evaluation Studies as Topic; D006801:Humans; D007621:Karyotyping; D007700:Kinetics; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000648:ultrastructure; D011123:Polyploidy; D011379:Prognosis
D004247:DNA