[Effect of phentolamine on the reflex increase in arterial pressure].
Experiments were carried out in anaesthetized and curarized cats to study the effects of the alpha-blocker phentolamine on arterial pressor response to stimulation of group I afferent fibers from gastrocnemius-soleus muscles. It has been found that increasing doses of phentolamine given i.v. cause a decreasing pressor response until complete disappearance occurs at 2.5 mg/Kg. It is concluded that pressor response is present only when the adrenergic control system is effective and, therefore, it is due mainly to an increase in peripheral vascular resistances.
Orani
G P
GP
Decandia
M
M
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004558:Electric Stimulation; D007275:Injections, Intravenous; D009132:Muscles / Q000294:innervation*; D010646:Phentolamine / Q000008:administration & dosage / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*
D010646:Phentolamine
Effetto della fentolamina sull'aumento riflesso della pressione arteriosa.