Oxytocin-induced motor disturbances: relationship with penile erection and yawning.
The intracerebroventricular (ICV) injection of oxytocin at doses between 5 and 100 ng induced repeated episodes of penile erection and yawning, while at doses between 100 ng and 10 micrograms it induced motor disturbances often culminating in barrel rotation in rats. The intensity of motor disturbances was inversely correlated to the number of yawning and penile erection episodes. Pretreatment with the dopaminergic agonist apomorphine (80 and 240 micrograms/kg SC) failed to modify the incidence of motor disturbance induced by high doses of oxytocin, but markedly reduced the intensity of the symptomatology in a dose-dependent manner. The present results suggest that high doses of oxytocin induce motor disturbances which mask penile erection and yawning, and that brain dopaminergic systems have a protective role against this symptomatology.
Melis
M R
MR
Department of Neurosciences, University of Cagliari, Italy.
Argiolas
A
A
Stancampiano
R
R
Gessa
G L
GL
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008297:Male; D009069:Movement Disorders / Q000378:metabolism* / Q000503:physiopathology; D010121:Oxytocin / Q000494:pharmacology*; D010410:Penile Erection / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced; D015000:Yawning / Q000187:drug effects*
D010121:Oxytocin