DFP induced changes in acetylcholinesterase activity and glycogen level in certain brain regions of mice.
DFP in acute dose (2 mg/kg i. p.) in mice significantly inhibited acetylcholinesterase AChE) activity in five regions of brain i.e. cerebral cortex, corpus striatum, medulla, cerebellum and hypothalamus. The inhibition was accompanied by depletion of glycogen from these regions 1 hr after DFP administration. The inhibition of enzyme activity was more in corpus striatum and medulla and glycogen depletion was more in cerebral cortex in comparison to other regions of the brain. These changes may be due to stimulatory effect of DFP on these regions of brain in mice.
Husain
K
K
Toxicology Division, Defence Research and Development Establishment, Gwalior.
Vijayaraghavan
R
R
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects*; D006003:Glycogen / Q000378:metabolism*; D007531:Isoflurophate / Q000494:pharmacology*; D008297:Male; D051379:Mice
D007531:Isoflurophate; D006003:Glycogen; D000110:Acetylcholinesterase