title: [A case of Wegener's granulomatosis with involvement of the aortic valve].
abstract: A clinico-morphological observation of Wegener granulomatosis in a 29-year-old man is described. The disease started with the gastrointestinal disorders followed by lung and renal disturbances which dominated. Heart enlargement and systolic-diastolic noise in the Botkin point were found. Infectious endocarditis with a complex aortal defect were diagnosed. The patient died 6 months later. The autopsy revealed a necrotizing lung granulomatosis, disseminated vasculitis, renal and spleen infarcts. Vasculitis with granulomatosis, destructive changes in the intima were found in the supravalvular part of the aorta and at the base of the aortic valve as well as severe fibrinous valvulitis.
authors.forename: V S
authors.initials: VS
authors.lastname: Timoshenko
authors.forename: O G
authors.initials: OG
authors.lastname: Polushin
authors.forename: A I
authors.initials: AI
authors.lastname: Fisenko
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000473:pathology*; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000473:pathology*; D006349:Heart Valve Diseases / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008297:Male
vernacular_title: Sluchaĭ granulematoza Vegenera s porazheniem aortal'nogo klapana.