title: Evaluation of several tests in screening for chloroquine maculopathy.
abstract: Patients receiving antimalarial therapy, specifically hydroxychloroquine, for different periods were evaluated using contrast sensitivity test (CST) and results were compared with those of electro-retinography (EOG), and pattern visual evoked potential (PVEP), and a matching age control group. The results indicated CST to be most sensitive of the evaluated techniques particularly in patients under 40 years old. In 44.4% of the cases CST revealed macular dysfunction of which the other two methods of examination were not capable. Our findings suggest the CST is a reliable and practical method which could be used as an additional screening test for chloroquine maculopathy.
authors.affiliation: Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: S A
authors.initials: SA
authors.lastname: Bishara
authors.forename: N
authors.initials: N
authors.lastname: Matamoros
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015350:Contrast Sensitivity; D004585:Electrooculography; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000009:adverse effects*; D008266:Macula Lutea / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010363:Pattern Recognition, Automated; D011237:Predictive Value of Tests; D011897:Random Allocation; D012164:Retinal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D015351:Vision Screening / Q000379:methods*; D014792:Visual Acuity
chemical_list: D006886:Hydroxychloroquine