Medullary neurons with projections to lamina X of the rat as demonstrated by retrograde labeling after HRP microelectrophoresis.
Brainstem neurons were retrogradely labeled with microelectrophoresis of HRP or WGA-HRP into lamina X of the cervical or lumbar cord of rats. The results reveal that lamina X of the lumbar cord receives bulbar projections originating mainly within the nucleus raphe magnus and the nucleus reticularis paragigantocellularis (including the medial or alpha-ventral part and lateral part) and that lamina X of the cervical cord receives projections from similar but more extensive regions in the lower brainstem. These findings provide a neuroanatomical substrate for medullary descending modulation of nociceptive transmission in lamina X.
Du
H J
HJ
Shanghai Brain Research Institute, Academia Sinica, China.
D000818:Animals; D005260:Female; D006735:Horseradish Peroxidase; D008297:Male; D008526:Medulla Oblongata / Q000166:cytology*; D009434:Neural Pathways; D010146:Pain / Q000503:physiopathology; D010544:Peroxidases; D011903:Raphe Nuclei / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology*
D006735:Horseradish Peroxidase; D010544:Peroxidases