[Optimization of hydroxythiamine administration regimen in vitaminological research].
A correlation between the different doses and inhibitory effect of hydroxythiamine relative to the activity of main thiamine pyrophosphate-dependent enzymes is studied in experiments on animals. It is established that the maximal inhibitory effect on the transketolase and oxoglutarate dehydrogenase activities is at a dose of antivitamin of 0.35 mmol/kg and that of pyruvate dehydrogenase of 0.55 mmol/kg. At lower doses of hydroxythiamine the inhibition of enzyme activities occurred in a dose-dependent manner.
Zimatkina
T I
TI
Oparin
D A
DA
Ostrovskiĭ
Iu M
IuM
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007655:Ketoglutarate Dehydrogenase Complex / Q000037:antagonists & inhibitors; D008297:Male; D051379:Mice; D010119:Oxythiamine / Q000008:administration & dosage*; D011768:Pyruvate Dehydrogenase Complex / Q000037:antagonists & inhibitors; D013844:Thiazoles / Q000008:administration & dosage*; D014174:Transketolase / Q000037:antagonists & inhibitors
D011768:Pyruvate Dehydrogenase Complex; D013844:Thiazoles; D010119:Oxythiamine; D007655:Ketoglutarate Dehydrogenase Complex; D014174:Transketolase
Optimizatsiia rezhima ispol'zovaniia oksitiamina v vitaminologicheskikh issledovaniiakh.