Fetal effects of inhalation exposure to cyclohexanone vapor in pregnant rats.
Cyclohexanone (CH), a solvent and thinner that has extensive use in industry, was investigated for developmental effects using pregnant Sprague-Dawley rats exposed to 100, 250 or 500 ppm concentrations in an inhalation chamber for seven hours per day from days 5 through 20 of pregnancy. Controls were exposed to room air. Maternal weight gain at 250 and 500 ppm CH was only slightly lower than in the control dams, and a grey mottling of the lungs was seen in a few of the CH-exposed dams. There were no significant differences between the CH and control groups in fetal weight, resorption sites, fetal death or sex ratio. External and soft tissue examinations revealed no significant incidence of malformations or variations in CH-exposed animals. A slight increase in the mean percent of rudimentary ribs per litter was observed in the 250 and 500 ppm CH-exposed groups. However, no significant numbers of skeletal malformations were noticed in either the CH or room air control groups. It was concluded that respiratory exposure of rats to as much as 500 ppm CH during organogenesis was unlikely to be developmentally toxic.
Samimi
B S
BS
Division of Occupational and Environmental Health, Graduate School of Public Health, San Diego State University, CA 92181-0405.
Harris
S B
SB
de Peyster
A
A
D000280:Administration, Inhalation; D000818:Animals; D003510:Cyclohexanes / Q000633:toxicity*; D003512:Cyclohexanones / Q000008:administration & dosage / Q000633:toxicity*; D005026:Ethylene Glycols / Q000008:administration & dosage / Q000633:toxicity; D005260:Female; D005333:Fetus / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D003510:Cyclohexanes; D003512:Cyclohexanones; D005026:Ethylene Glycols; C036468:cyclohexanone; C021296:2-ethoxyethanol