title: [Selective inducing ability of DL-111-1T towards mixed function oxidase in female rat liver and human amnion fluid cell].
abstract: Following pretreatment of adult female rats with contragestational agent 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazol (DL 111-1T) 20 mg/kg.d for 2 consecutive days, the hepatic microsomal MFO and UDPGT activities were induced to a constant level, being characteristic of arylhydrocarbon type of induction. Coincubation of human amnion FL cell with 0.1 mumol/L of DL-111-1T for 24 h produced a 4.5-fold induction of AHH activity of the cell. This inducing ability was 3 times that of PB, but 1/2 that of 3-MC. According to these observations, DL-111-1T may also be considered as a polycyclic arylhydrocarbon type inducer toward human amnion FL cell's MFO which contains mainly of cytochrome P-448. UDS test showed that DL-111-1T itself could not induce UDS of FL cell.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Lin
authors.forename: L
authors.initials: L
authors.lastname: Sun
authors.forename: Y N
authors.initials: YN
authors.lastname: Yu
mesh_terms: D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D000650:Amnion / Q000166:cytology; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005260:Female; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D014230:Triazoles; C030266:3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases