Testing whether an identified treatment is best.
We consider the problem of testing whether an identified treatment is better than each of K treatments. Suppose there are univariate test statistics Si that contrast the identified treatment with treatment i for i = 1, 2,...., K. The min test is defined to be the alpha-level procedure that rejects the null hypothesis that the identified treatment is not best when, for all i, Si rejects the one-sided hypothesis, at the alpha-level, that the identified treatment is not better than the ith treatment. In the normal case where Si are t statistics the min test is the likelihood ratio test. For distributions satisfying mild regularity conditions, if attention is restricted to test statistics that are monotone nondecreasing functions of Si, then regardless of their covariance structure the min test is an optimal alpha-level test. Tables of the sample size needed to achieve power .5, .8, .90, and .95 are given for the min test when the Si are Student's t and Wilcoxon.
Laska
E M
EM
Statistical Sciences & Epidemiology Division, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.
Meisner
M J
MJ
D001699:Biometry; D002985:Clinical Protocols; D006801:Humans; D015233:Models, Statistical; D013812:Therapeutics