title: Qualitative platelet defects in chronic myeloproliferative disorders: evidence for reduced ATP secretion.
abstract: 19 consecutive untreated patients with chronic myeloproliferative disorders and thrombocytosis were subjected to comprehensive platelet function tests including platelet aggregometry. 12 patients had essential thrombocythaemia (ET) and 7 patients had polycythaemia vera (PV). Bleeding time was normal. Arachidonic acid, collagen and ristocetin aggregation were abnormal only in a minority of patients, whereas ADP aggregation was impaired in 16 out of 19 patients. The most conspicuous findings were abolished second-wave adrenalin aggregation, increased ADP aggregation threshold, and markedly reduced ATP secretion during collagen-induced aggregation. This triad of qualitative platelet defects seems to be a good diagnostic marker of chronic myeloproliferative disease with thrombocytosis.
authors.affiliation: Department of Internal Medicine, Umeå University Hospital, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Löfvenberg
authors.forename: T K
authors.initials: TK
authors.lastname: Nilsson
mesh_terms: D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate / Q000097:blood / Q000378:metabolism*; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000502:physiology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D010974:Platelet Aggregation / Q000187:drug effects
chemical_list: D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate