Multiple sclerosis is associated with HLA-DR2 antigen in Spain.
One hundred and twenty-one Spanish multiple sclerosis patients were typed for HLA antigens. We found a significant increase of HLA-DR2 (p less than 0.004) compared with local normal controls. We confirm similar findings in other Caucasian populations.
Clerici
N
N
Department of Immunology, Hospital Ramón y Cajal, Madrid, Spain.
Hernández
M
M
Fernández
M
M
Rosique
J
J
Alvarez-Cermeño
J
J
D000328:Adult; D005260:Female; D006683:HLA-DQ Antigens / Q000032:analysis; D015802:HLA-DR2 Antigen / Q000032:analysis* / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology*; D010641:Phenotype; D013030:Spain
D006683:HLA-DQ Antigens; C051568:HLA-DQ1 antigen; D015802:HLA-DR2 Antigen