Recent studies on nucleoside H-phosphonothioate and nucleoside methylphosphonothioate synthesis.
The reaction of suitably protected nucleosides with phosphinic acid in the presence of condensing agents has been investigated and applied for the preparation of nucleoside 3'-H-phosphonothioates. Studies on synthesis and separation of diastereoisomers of nucleoside 3'-methylphosphonothioates are also discussed.
Stawiński
J
J
Department of Organic Chemistry, Arrhenius Laboratory, University of Stockholm, Sweden.
Szabó
T
T
Thelin
M
M
Westman
E
E
Zain
R
R
D010721:Phosphinic Acids; D013237:Stereoisomerism; D013873:Thionucleotides / Q000138:chemical synthesis*
D010721:Phosphinic Acids; D013873:Thionucleotides