Amitriptyline: linear or nonlinear kinetics in every day practice?
The linearity of the (AMT) kinetics of amitriptyline has been tested in 135 depressed dosed twice daily by measuring plasma. Their (AMT) and nortriptyline (NT) levels under steady-state conditions. The AMT concentration/dose ratios at low and high dosages were not significantly different and there was a linear relationship between the dose ratios and the concentration ratios. No change in the metabolic ratio (AMT/NT) was observed between the two dosages. Although the results are consistent with linear AMT kinetics, there may have been nonlinear kinetics in some patients as the ratio between the concentration/dose ratios in them at low and high dosages was greater than one. Those patients were characterized by a low concentration/dose ratio at low dosage. No clinical adverse effect appeared in the study.
Vandel
S
S
Laboratoire de Pharmacologie Clinique, CHU of Besançon, France.
Bertschy
G
G
Vandel
B
B
Allers
G
G
Volmat
R
R
D000639:Amitriptyline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001711:Biotransformation; D003863:Depression / Q000188:drug therapy*; D006801:Humans; D016014:Linear Models; D009661:Nortriptyline / Q000097:blood*
D000639:Amitriptyline; D009661:Nortriptyline