[Characteristics of the carcinogenic effect of benzo(a)pyrene after its combined intake and the problems of its standardization in the environment].
During the experiments on 952 white random-bred mice a scale of benz(a)pyrene (BP) doses from 10 to 0.0001 mg was studied under isolated peroral, intratracheal and complex effect. Dose-time relationship of carcinogenic effect was described. It was demonstrated that for large doses complex intake of carcinogens was determined by the effect of taking antilogarithms and for threshold doses by independent action. It was concluded that MAC for BP under complex effect should not exceed the sum of its earlier established admissible concentrations for atmospheric air and water reservoirs.
Chernichenko
I A
IA
D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D001564:Benzo(a)pyrene / Q000008:administration & dosage / Q000592:standards / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced*; D008452:Maximum Allowable Concentration; D051379:Mice; D013274:Stomach Neoplasms / Q000139:chemically induced*
D004785:Environmental Pollutants; D001564:Benzo(a)pyrene
Osobennosti kantserogennogo deĭstviia benz(a)oirena pri kompleksnom postuplenii v organizm i voprosy normirovaniia ego v ukruzhaiushcheĭ srede.