title: [The ratio of collagens type I and III in cultures of human fibroblasts with diploid and aberrant chromosome complement].
abstract: The ratio of collagens I/III was studied in human diploid, trisomic and triploid fibroblast strains. The following material was used in experiments: 5 strains obtained from human spontaneous abortuses (trisomy 7, trisomy 9, triploidy), 6 diploid embryonic strains, 4 strains from patients with Down syndrome, 3 strains from healthy children, 4 strains from healthy adult donors and 3 strains from very old persons (81-107 years old). Various types of collagen were separated by means of electrophoresis. Distinct ontogenetic alterations were not observed in content of collagen III in diploid and aneuploid human cultivated fibroblasts. However, considerable alterations in the ratio of collagens I/III correlated with genetic pathologies only in the patients examined.
authors.forename: V I
authors.initials: VI
authors.lastname: Kukharenko
authors.forename: E M
authors.initials: EM
authors.lastname: Pichugina
authors.forename: A A
authors.initials: AA
authors.lastname: Del'vig
mesh_terms: D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003094:Collagen / Q000378:metabolism*; D004171:Diploidy; D005347:Fibroblasts / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans
chemical_list: D003094:Collagen
vernacular_title: Sootnoshenie kollagena tipov I i III v shtammakh fibroblastnykh kletok cheloveka s diploidnym i anomal'nym naborom khromosom.