title: Liver mitochondrial respiratory functions decline with age.
abstract: Human liver mitochondrial respiration rates in Chinese populations of various ages were assayed with an oxygraph. In this study, State 3 and State 4 respiration rates, respiratory control ratio (RCR), and ADP/O ratio were measured for 35 Chinese subjects of 31 to 76 years old. We found a significant negative correlation between age and respiratory control and ADP/O ratios tested. Moreover, the respiratory control and ADP/O ratios decreased with the increase of age. These findings suggest that a substantial fall in mitochondrial oxidative capacity in ageing liver may be an important contributor to the ageing process.
authors.affiliation: Department of Biochemistry, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China.
authors.forename: T C
authors.initials: TC
authors.lastname: Yen
authors.forename: Y S
authors.initials: YS
authors.lastname: Chen
authors.forename: K L
authors.initials: KL
authors.lastname: King
authors.forename: S H
authors.initials: SH
authors.lastname: Yeh
authors.forename: Y H
authors.initials: YH
authors.lastname: Wei
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*
chemical_list: D000244:Adenosine Diphosphate