title: Blood concentrations after accidental cyclosporin overdose.
abstract: Two cases of children are reported with an accidental oral overdose of cyclosporin in whom blood concentrations were monitored. Despite a tenfold oral overdose, the peak blood concentrations of cyclosporin in both patients were only moderately increased above therapeutic levels. Apart from a transient rise in blood pressure in one patient, no toxic effects of cyclosporin were noticed.
authors.affiliation: Department of Paediatrics, University Hospital Groningen, The Netherlands.
authors.forename: K
authors.initials: K
authors.lastname: de Meer
authors.forename: R H
authors.initials: RH
authors.lastname: Houwen
authors.forename: C M
authors.initials: CM
authors.lastname: Bijleveld
authors.forename: D R
authors.initials: DR
authors.lastname: Uges
authors.forename: M J
authors.initials: MJ
authors.lastname: Slooff
mesh_terms: D001682:Biological Availability; D002675:Child, Preschool; D003524:Cyclosporins / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008103:Liver Cirrhosis / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D016031:Liver Transplantation; D008297:Male
chemical_list: D003524:Cyclosporins