A magnetic resonance imaging contrast agent differentiates between the vascular properties of fetal striatal tissue transplants and gliomas in rat brain in vivo.
The tumors formed by rat C-6 glioma cells were isointense with the normal rat brain on precontrast T1 weighted magnetic resonance (MR) images. Following i.v. peripheral administration of the MR imaging contrast agent gadolinium (Gd)-DTPA, there was no significant change in the signal intensity from normal brain tissue. However, the tumor appeared as areas of high signal intensity demonstrating the abnormal vascular properties of the tumor. Fetal rat striatal tissue transplanted into unlesioned adult rat striatum appeared isointense with the host brain on precontrast T1 weighted images and there was no evidence for enhancement of the transplanted tissue relative to host brain following i.v. administration of Gd-DTPA. Using this technique we found no evidence with respect to permeability of the contrast agent of an abnormal blood-brain barrier within the striatal transplant in vivo.
Norman
A B
AB
Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267.
Thomas
S R
SR
Pratt
R G
RG
Samaratunga
R C
RC
Sanberg
P R
PR
D000818:Animals; D001932:Brain Neoplasms / Q000098:blood supply / Q000175:diagnosis*; D003287:Contrast Media; D003342:Corpus Striatum / Q000098:blood supply / Q000637:transplantation*; D019786:Gadolinium DTPA; D005910:Glioma / Q000098:blood supply / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid; D051381:Rats; D011919:Rats, Inbred Strains
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA