[The possibilities of an individual approach to intra-articular drug administration in rheumatoid arthritis patients].
A study was made of the possibilities of an individual approach to intraarticular administration of protease inhibitors, cytostatics and orgoteine in patients with rheumatoid arthritis (RA). The activity of hyaluronidase, superoxide dismutase, the level of rheumatoid factor and the phagocyte count in synovial fluid were examined. With regard to the results of synovial fluid analysis in 67 RA patients, contrykal, orgoteine or cyclophosphamide were administered intra-articularly (based on an individual approach) in addition to corticosteroid hormones. It has been shown that with the individual approach to intraarticular drug administration the number of repeated punctures of the joints decreased by 18.8% while the amount of glucocorticosteroid hormones administered was twice as reduced.
Matveĭkov
G P
GP
Soroka
N F
NF
Maksimovich
A B
AB
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000201:enzymology; D003520:Cyclophosphamide / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D006801:Humans; D007270:Injections, Intra-Articular / Q000379:methods; D015552:Injections, Intralesional / Q000379:methods; D011480:Protease Inhibitors / Q000008:administration & dosage; D013256:Steroids; D013582:Synovial Fluid / Q000187:drug effects / Q000201:enzymology
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D011480:Protease Inhibitors; D013256:Steroids; D003520:Cyclophosphamide
Vozmozhnosti individual'nogo podkhoda k vnutrisustavnomu vvedeniiu medikamentov bol'nym revmatoidnym artritom.