title: [Local analgesic action and tissue irritability of nishika thesirol, a root canal disinfectant].
abstract: Local analgesic action and tissue irritability of nishika thesirol made newly, which was one of the root canal disinfectants, were investigated. 1) Nishika thesirol was less irritative than any other drugs such as formocresol, champhophenique and creodon, and there was a significant difference between nishika thesirol and formocresol. 2) Marked local analgesic action of nishika thesirol was observed by means of formalin method in mice. Formalin-induced pain response was also inhibited significantly, when nishika thesirol was directly applied to the sciatic nerve 3 days before the experiment. 3) Thesit, one of the effective ingredients of nishika thesirol, had a long lasting local anesthetic action as compared with the same dose of lidocaine.
authors.forename: M
authors.initials: M
authors.lastname: Shibata
authors.forename: T
authors.initials: T
authors.lastname: Ohkubo
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D006801:Humans; D012388:Root Canal Irrigants / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D012388:Root Canal Irrigants