[Studies on antigenicity and contact sensitivity of miporamicin].
Experiments were performed to assess antigenicity and contact sensitivity of miporamicin (MPM) with the results leading to the conclusions as follows: 1. In the test to find out if an active systemic anaphylactic reaction would occur in guinea pigs, none of the animals developed any typical signs of anaphylactic reaction. 2. All the sera samples obtained from guinea pigs which had been given sensitizing injections of MPM proved negative for homologous PCA reaction. 3. In a test to see if PCA reaction would occur in rats, all the sera samples obtained from mice which had been given sensitizing injections of MPM did not cause positive reactions. 4. MPM was negative for contact sensitivity tested in guinea pigs; thus, no evidence of contact sensitizing potential was observed. Thus, MPM has proven to be not antigenic in guinea pigs or mice, nor to have any contact sensitivity in guinea pigs under the testing conditions employed.
Nakano
Y
Y
Biological and Toxicological Research Laboratories, Toyo Jozo Co., Ltd.
Goto
I
I
Kobayashi
Y
Y
Matsumoto
K
K
Yamamoto
H
H
D000707:Anaphylaxis / Q000139:chemically induced*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000276:immunology / Q000633:toxicity*; D003877:Dermatitis, Contact / Q000209:etiology*; D006168:Guinea Pigs; D018942:Macrolides; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000900:Anti-Bacterial Agents; D018942:Macrolides; C063027:mirosamicin