title: Middle latency response: frequency and intensity effects.
abstract: Auditory middle latency responses (MLR) and auditory brainstem responses (ABR) were measured with epidural electrodes in unanesthetized gerbils. Response thresholds of simultaneously recorded MLRs and ABRs, and latencies and amplitudes of MLR peaks were analyzed with respect to stimulus intensity (10-80 dB SPL) and frequency (0.5, 1, 2, 4, 8 and 16 kHz). Only minor changes in the latencies of the MLR were associated with increases in stimulus intensity. Changes in latencies were more apparent for waves A and B as compared to wave C, and were significant only at low intensities. Latencies did not change significantly as a function of stimulus frequency. Amplitudes of the MLR were highly variable between animals, particularly waves B and C, and showed complex changes with intensity. In general, wave amplitudes were inversely related to stimulus frequency. The gerbil MLR resembles MLRs recorded under similar conditions in guinea pig, cat, and rat. Some qualitative similarities between gerbil and human MLRs are apparent. Results indicate that the MLR is a less sensitive measure of hearing threshold relative to the fast waves of the ABR at frequencies above 1 kHz. However, clearly defined MLRs are elicited with a wide range of stimulus frequencies. Because the surface recorded MLR reflects activation of central auditory pathways, including the cortex, it may provide an electrophysiological measure which can be utilized to study central components of normal and pathological auditory function.
authors.affiliation: Dept. of Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston, SC 29425.
authors.forename: D I
authors.initials: DI
authors.lastname: Smith
authors.forename: F S
authors.initials: FS
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Mills
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001933:Brain Stem / Q000502:physiology; D004056:Differential Threshold; D005072:Evoked Potentials, Auditory; D005849:Gerbillinae; D011930:Reaction Time; D013702:Temporal Lobe / Q000502:physiology