Different invasion capacity of NBT II and MDCK in the chick embryo chorioallantois.
Questions have been raised as to the validity of the chick embryo chorioallantoic membrane for studying malignant invasion. Two cell lines, the invasive and non-invasive character of which we have documented in another system, were used in the CAM model to test for similar behaviour. Results showed that NBT II cells, an invasive tumour in the rat and in the confrontation assay, penetrated the ectoderm and grew within the mesoderm. MDCK, of low tumourigenicity in nude mice and non-invasive in the confrontation assay, did not form morphologically defined tumours and no MDCK cells were seen in the mesoderm.
Schroyens
W
W
Justus-Liebig-Universität Giessen, Dept. Hematology-Oncology, F.R.G.
Schroyens
E
E
Bielunas
J
J
D000481:Allantoin; D000818:Animals; D002460:Cell Line; D002642:Chick Embryo; D002823:Chorion / Q000166:cytology*; D009361:Neoplasm Invasiveness; D051381:Rats; D011919:Rats, Inbred Strains; D014407:Tumor Cells, Cultured / Q000166:cytology; D001749:Urinary Bladder Neoplasms / Q000473:pathology*
D000481:Allantoin