title: [A case of pneumonitis due to sho-saiko-to].
abstract: We reported a case of pneumonitis due to Sho-saiko-to. A 71-year-old woman was admitted to our hospital because of pneumonia. She complained of dry cough, pyrexia and severe dyspnea. Fine crepitation was heard on physical examination of the chest and a chest X-ray film revealed diffuse reticulo-nodular shadow in both lung fields. We suspected summer-type hypersensitivity pneumonitis and followed her up, however her condition deteriorated. Under a suspicion of drug-induced pneumonitis, all drugs were stopped and she was given prednisolone. Consequently her complaints, laboratory data and chest X-ray findings markedly improved. Microscopic examination of a transbronchial lung biopsy specimens showed interstitial pneumonitis. The results of a lymphocyte stimulation test were positive for sho-saiko-to. She gave informed consent after receiving an explanation of the challenge test. She was tested with 2.5 g sho-saiko-to twice and developed high fever and dyspnea with hypoxia, while the chest X-ray film also revealed diffuse infiltrative shadows similar that on admission. Based on these findings, we diagnosed this case as pneumonitis due to sho-saiko-to. To our knowledge, there has been no previous case of pulmonary hypersensitivity due to sho-saiko-to reported in the world.
authors.forename: K
authors.initials: K
authors.lastname: Tsukiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Tasaka
authors.forename: M
authors.initials: M
authors.lastname: Nakajima
authors.forename: J
authors.initials: J
authors.lastname: Hino
authors.forename: C
authors.initials: C
authors.lastname: Nakahama
authors.forename: N
authors.initials: N
authors.lastname: Okimoto
authors.forename: S
authors.initials: S
authors.lastname: Yagi
authors.forename: R
authors.initials: R
authors.lastname: Soejima
mesh_terms: D000368:Aged; D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011658:Pulmonary Fibrosis / Q000139:chemically induced*
chemical_list: D004365:Drugs, Chinese Herbal; C018142:saiko-keishi-to