title: Central motor conduction and glutamate deshydrogenase: activity in olivo-ponto-cerebellar atrophy.
abstract: Central motor conduction was investigated by way of magneto-electric cortico-spinal stimulation in 6 patients with sporadic olivo-ponto-cerebellar atrophy. Two patients were found to have reduced leucocyte GDH activity. Only the 3 patients with corticospinal deficits displayed increased central conduction rates, which were predominant in the lower limbs. The duration of the disease is statistically longer in patients with corticospinal deficit compared to patients with no corticospinal deficit. In OPCA, evoked motor potentials are useful in assessing the corticospinal deficit which does not appear to be linked to reduced leucocyte GDH activity.
authors.affiliation: Department of Neurology, University Hospital, Limoges, France.
authors.forename: F
authors.initials: F
authors.lastname: Tabaraud
authors.forename: J
authors.initials: J
authors.lastname: Hugon
authors.forename: J Y
authors.initials: JY
authors.lastname: Salle
authors.forename: J M
authors.initials: JM
authors.lastname: Boulesteix
authors.forename: M
authors.initials: M
authors.lastname: Rigaud
authors.forename: J M
authors.initials: JM
authors.lastname: Vallat
authors.forename: M
authors.initials: M
authors.lastname: Dumas
mesh_terms: D000328:Adult; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005969:Glutamate Dehydrogenase / Q000097:blood*; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology*; D009849:Olivopontocerebellar Atrophies / Q000097:blood / Q000201:enzymology / Q000503:physiopathology*; D013132:Spinocerebellar Degenerations / Q000503:physiopathology*
chemical_list: D005969:Glutamate Dehydrogenase