Expression of HLA-class II antigens and proliferative capacity in autologous mixed lymphocyte reactions of human T lymphocytes exposed in vitro to alpha-endorphin.
alpha-Endorphin (aEP) inhibited the expression of HLA-Class II antigens by PHA-primed T lymphocytes and reduced mitogen-induced T-cell proliferation up to 35%. This action was time related and not naloxone sensitive. When aEP was added to autologous and allogeneic lymphocyte cultures (both of non-T/T and T/T type), it inhibited lymphocyte blastogenesis up to 40%. These findings, indicating that aEP can influence some functions of immunocompetent cells, provide evidence for the functional interrelationship between the neuroendocrine and the immune systems.
Morgano
A
A
Istituto Scientifico di Medicina Interna, University of Genoa, Italy.
Setti
M
M
Pierri
I
I
Barabino
A
A
Lotti
G
G
Indiveri
F
F
D000328:Adult; D002478:Cells, Cultured; D004723:Endorphins / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006680:HLA Antigens / Q000378:metabolism*; D006801:Humans; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D004723:Endorphins; D006680:HLA Antigens; D010835:Phytohemagglutinins