Erythrocyte glyoxalase activity in genetically obese (ob/ob) and streptozotocin diabetic mice.
Hyperglycemia associated with the manifestation of the obese diabetic (ob/ob) syndrome in mice and the short and long term streptozotocin treatment of lean MF1 mice was accompanied by a significant decrease in erythrocyte glyoxalase 1 activity and a marked increase in the concentration of the alpha-oxoaldehyde methylglyoxal. Erythrocyte glyoxalase II activity was modestly but significantly elevated in both obese mice and short term streptozotocin treated MF1 mice but no significant changes in S-D-lactoylglutathione concentration could be detected. Modification of the cells glyoxalase system during hyperglycaemia, especially the enhanced production of methylglyoxal may be a significant biochemical factor in the development of diabetic complications.
Atkins
T W
TW
Pharmaceutical Sciences Institute, Aston University, Birmingham, UK.
Thornally
P J
PJ
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005978:Glutathione / Q000031:analogs & derivatives / Q000097:blood; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000097:blood / Q000201:enzymology* / Q000235:genetics; D011765:Pyruvaldehyde / Q000097:blood; D013869:Thiolester Hydrolases / Q000097:blood*; D000099301:Hydroxyacylglutathione Hydrolase
D001786:Blood Glucose; D005978:Glutathione; D011765:Pyruvaldehyde; D013869:Thiolester Hydrolases; D000099301:Hydroxyacylglutathione Hydrolase; C013585:S-lactoylglutathione