[The existence of sinusitis in rabbits and the use of bromhexine as a mucolytic nose drop in the treatment of sinusitis].
To make an experimental sinusitis, 38 maxillary sinus ostia of 19 rabbits were closed by silicon plastic and 24 hours later 10(8)-10(10) germs/ml. of Streptococcus pneumoniae type C III were given to the antrums of sinuses. 5 days later all the rabbits showed sinusitis clinically, radiologically, bacteriologically and histopathologically. Viscous, purulent secretions collected in the antrums of sinuses. We thought that the medical treatment of sinuses which had drainage treatment necessitated to decrease the viscosity of secretions. Because of this bromhexine as a mucolytic nose drop was investigated for the first time for the treatment of sinusitis in two groups of rabbits. As a result of the study bromhexine as a nose drop in the eradication of sinus infections was seen a useful drug.
Koyuncu
M
M
Ogretim Uyesi, Firat Universitesi, Kulak Burun Boğaz Anabilim Dah, Elaziğ.
Yilmaz
M
M
Yalçin
S
S
Metin
N
N
Gündüz
S
S
Karataş
E
E
D000281:Administration, Intranasal; D000818:Animals; D001964:Bromhexine / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004322:Drainage; D011817:Rabbits; D012852:Sinusitis / Q000188:drug therapy*
D001964:Bromhexine
Tavşanlarda deneysel sinüzit oluşturulmasi ve burun damlasi şeklinde hazirlanan mukolitik bromhexine'in sinüzit tedavisindeki yeri.