title: Characterization of the rabbit aorta endothelium-dependent cholinergic receptor by agonist equipotent molar doses.
abstract: The endothelium-dependent acetylcholine, metacholine, carbachol, betanechol, and furtrethonium relaxation values have been measured in vitro for the rabbit aorta, in presence of a high concentration of hexamethonium. The produced EPMR values complete the values that were obtained in a previous experiment under analogous conditions for rat bladder, ileum, iris, stomach, and trachea preparations. The complete set was analyzed by new statistical techniques of data analysis and display, which are both simpler and more precise than the statistical modeling techniques used by us in the past. This has led to new results concerning the clustering of drugs and of receptors, as well as to a characterization of the endothelium receptor.
authors.affiliation: C.S.I.R./C.A.C.D.S., Pretoria, South Africa.
authors.forename: D
authors.initials: D
authors.lastname: Bradu
authors.forename: B
authors.initials: B
authors.lastname: Di Sarra
authors.forename: C
authors.initials: C
authors.lastname: Concettoni
authors.forename: V
authors.initials: V
authors.lastname: Moretti
authors.forename: P
authors.initials: P
authors.lastname: Pagelli
authors.forename: L
authors.initials: L
authors.lastname: Re
authors.forename: L
authors.initials: L
authors.lastname: Rossini
authors.forename: C
authors.initials: C
authors.lastname: Tonnini
mesh_terms: D000818:Animals; D001011:Aorta / Q000032:analysis*; D004353:Drug Evaluation, Preclinical; D004727:Endothelium / Q000032:analysis; D066298:In Vitro Techniques; D008297:Male; D009994:Osmolar Concentration; D010277:Parasympathomimetics / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D011817:Rabbits; D011950:Receptors, Cholinergic / Q000032:analysis / Q000145:classification* / Q000187:drug effects; D013223:Statistics as Topic
chemical_list: D010277:Parasympathomimetics; D000644:Quaternary Ammonium Compounds; D011950:Receptors, Cholinergic; C028530:furtrethonium