The influence of topical prostaglandins on HSA-induced uveitis in the rabbit.
In this study the effect of topical administration of prostaglandins (PGs) on a human serum albumin (HSA)-induced uveitis is evaluated. Topical prostaglandin E1 (PGE1) and prostaglandin F2 alpha (PGF2 alpha) partly inhibited hyperaemia and flare in the anterior chamber after the induction of immune complex uveitis. A marked increase in the cellular response was observed in the aqueous humour after topical PGE1 and PGF2 alpha. Topical prostaglandins may decrease endogenous prostaglandin formation and reduce the prostaglandin-mediated inflammatory symptoms; on the other hand, they also stimulate the aqueous cellular response, possibly by facilitation of leukotriene formation. These results indicate that topical prostaglandins should not be used to treat immunogenic uveitis.
Hoyng
P F
PF
Department of Experimental Ophthalmology, The Netherlands Ophthalmic Research Institute, Amsterdam.
D000287:Administration, Topical; D000527:Alprostadil / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects; D001082:Aqueous Humor / Q000187:drug effects / Q000276:immunology; D003228:Conjunctiva / Q000098:blood supply; D015237:Dinoprost / Q000008:administration & dosage / Q000494:pharmacology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006940:Hyperemia / Q000188:drug therapy; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D012709:Serum Albumin; D014606:Uveitis, Anterior / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology
D011458:Prostaglandins E; D012709:Serum Albumin; D015237:Dinoprost; D000527:Alprostadil