title: Influences of related retroviruses on lymphocyte functions.
abstract: The human immunodeficiency virus (HIV-1) is known to be profoundly immunosuppressive [Spickett and Dalgleish (1988) Clin. Exp. Immunol. 71, 1]. In this communication, we have studied the influences of HIV-1 (BH10), HIV-2 (LAV-2) and STLV-3 on B and T cells from healthy volunteers. B lymphocytes were found to differentiate into immunoglobulin secreting cells in response to stimulation by proteins of HIV-1 and LAV-2, but not by STLV-3. This response was obtained at protein concentrations of 0.05-0.005 micrograms/ml and was T cell dependent. IgM secretion was induced only by HIV-1 in the EBV-transformed B cell line SKW 6.4. At higher concentrations all three retroviral preparations had inhibitory influences on functions of B as well as T lymphocytes. B cell differentiation was maximally inhibited by HIV-1 and LAV-2 when these proteins were added concurrently to cultures with the polyclonal B cell activators pokeweed mitogen or Epstein-Barr virus. Tetanus antigen-specific T cell lymphoproliferation was inhibited by all retroviral proteins. These findings suggest that related retroviruses differ in their capacity to influence normal immune responses.
authors.affiliation: Department of Pediatrics, North Shore University Hospital, Cornell University Medical College, Manhasset, NY 11030.
authors.forename: N
authors.initials: N
authors.lastname: Chirmule
authors.forename: C
authors.initials: C
authors.lastname: Saxinger
authors.forename: S
authors.initials: S
authors.lastname: Pahwa
mesh_terms: D002454:Cell Differentiation; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D066298:In Vitro Techniques; D015850:Interleukin-6 / Q000276:immunology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D012190:Retroviridae / Q000276:immunology*; D012191:Retroviridae Proteins / Q000276:immunology
chemical_list: D007136:Immunoglobulins; D015850:Interleukin-6; D012191:Retroviridae Proteins