Effects of angiotensin II and its fragments: angiotensin II(3-8)-hexapeptide and angiotensin II(4-8)-pentapeptide on retrieval in passive avoidance situation in rats chronically treated with ethanol.
Rats with impaired retrieval of passive avoidance behavior induced by chronic (9 weeks) administration of ethanol were studied. Angiotensin II (AII) and its fragments: AII(3-8) and AII(4-8), administered (icv, 2.0 micrograms) on the third day after ethanol withdrawal, neutralized the toxic effect of ethanol. Furthermore, the peptide AII(3-8) also gave an improvement in retrieval of the capability to perform simple behavioral tasks as it did in the control group in rats chronically pretreated with alcohol.
Borawska
M
M
Department of Pharmacology, Medical Academy, Białystok, Poland.
Kupryszewski
G
G
Witczuk
B
B
Wiśniewski
K
K
D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000809:Angiotensins / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000809:Angiotensins; D010446:Peptide Fragments; D000804:Angiotensin II; C012877:angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-; D000431:Ethanol; C022782:angiotensin pentapeptide