title: Treatment-related central nervous system toxicity: MR imaging evaluation with CT and clinical correlation.
abstract: Thirteen patients with abnormal brain MR scans attributable to treatment-induced injury were retrospectively reviewed. All patients were treated with radiation therapy and 62% received chemotherapy. Five patients were graded as having severe white matter (WM) changes, four had moderate WM changes, and four had mild WM changes. CT was generally equivalent to MR in evaluation of severe and moderate WM abnormalities, whereas MR was superior to CT in detection of mild WM abnormalities. In general, the severity of changes depicted by MR/CT correlated with the extent of neurologic dysfunction. The most severe changes were seen in those patients treated with combination irradiation and chemotherapy.
authors.affiliation: Division of Radiation Onocology, University of Colorado Health Sciences Center, Denver 80262.
authors.forename: M B
authors.initials: MB
authors.lastname: Hazuka
authors.forename: J J
authors.initials: JJ
authors.lastname: Kinzie
authors.forename: K A
authors.initials: KA
authors.lastname: Davis
authors.forename: D A
authors.initials: DA
authors.lastname: DeBoise
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001927:Brain Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000175:diagnosis* / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents