[The effect of a hypocaloric diet enriched with polyunsaturated fatty acids on various indicators of cellular immunity in obese children].
A total of 157 children aged from 3 to 14 years with varying clinico-pathogenetic types of obesity have been investigated. The main method used for pathogenetic correction was a hypocaloric diet. Twenty-five children in addition to the hypocaloric diet received polyunsaturated fatty acids (PUSFA), nonpurified oil, 0.5-1 g/kg, as an additive to vegetable and meat salads, two times a week, in relief days. Immunological parameters, cholesterol, total lipids, lipoprotein spectrum of the blood were studied. Statistically significant increase of the relative content of T-lymphocytes and theophylline-resistant lymphocytes, with simultaneous diminution of null cell number in children, who received additional PUSFA, was, possibly, associated with the stimulating effect of PUSFA on the differentiation of young precursor-lymphocytes, or with the release of T-lymphocyte receptors due to normalization of lipid metabolism. The investigations conducted have shown a positive effect of the hypocaloric diet enriched with oil on the general condition, regression of body mass in the children under study. The favourable effect of oil on the immunologic processes has evidenced the merit of its use as an immunostimulant, and the necessity of the further study of immunocorrective properties of PUSFA.
Kravets
E B
EB
Kniazev
Iu A
IuA
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004038:Diet, Reducing; D002149:Energy Intake; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D006801:Humans; D007111:Immunity, Cellular; D008055:Lipids / Q000097:blood; D009765:Obesity / Q000178:diet therapy / Q000276:immunology*
D005231:Fatty Acids, Unsaturated; D008055:Lipids
Vliianie gipokaloriĭnoĭ diety, obogashchennoĭ polinenasyshchennymi zhirnymi kislotami, na nekotorye pokazateli kletochnogo immuniteta u deteĭ s ozhireniem.