Serial ultrastructural studies of scrapie in hamsters.
We report sequential studies of the ultrastructural neuropathology of the subcortical grey matter of hamsters infected with the 263K strain of scrapie virus. Vacuolation in this model develops relatively late in the incubation period, while tubulovesicular structures appear early. Furthermore, neuroaxonal dystrophy, accumulations of branching tubules, and neuronal change consisting of intracytoplasmic "whorls" of proliferating membranes constitute prominent features of scrapie-related neurodegeneration.
Liberski
P P
PP
Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders, Stroke, Bethesda, Maryland, MD 20892.
Asher
D M
DM
Yanagihara
R
R
Gibbs
C J
CJ
Gajdusek
D C
DC
D000818:Animals; D001253:Astrocytes / Q000648:ultrastructure; D001369:Axons / Q000648:ultrastructure; D001921:Brain / Q000648:ultrastructure*; D006224:Cricetinae; D003712:Dendrites / Q000648:ultrastructure; D005260:Female; D008297:Male; D008647:Mesocricetus; D008854:Microscopy, Electron; D009474:Neurons / Q000648:ultrastructure*; D012608:Scrapie / Q000473:pathology*; D013572:Synaptic Vesicles / Q000648:ultrastructure; D014617:Vacuoles / Q000648:ultrastructure