title: Modulation of lead-induced performance deficit in children by varying signal rate in a serial choice reaction task.
abstract: Evidence is presented showing that serial choice reaction performance is disrupted at low blood lead levels (PbB), and that parametric variation of task characteristics modulates the degree of disruption. This evidence is based on two independent studies in 6- to 9-year-old children living in two lead smelter areas in the cities of Nordenham (N = 114) and Stolberg (N = 109) in West Germany. Average PbB was 8.2 micrograms/100 ml (4.4-23.8 micrograms/100 ml) in the Nordenham sample and 7.4 micrograms/100 ml (4.2-18.0 micrograms/100 ml) in the Stolberg sample. Serial choice reaction performance was assessed by means of the Vienna reaction device in which a random sequence of light and tone signals has to be answered by pressing appropriate response buttons. Correct (hits) and false responses (errors) were evaluated as performance measures, and signal rate was varied in order to achieve easy and difficult task conditions. Exposure-related performance deficit was more pronounced for errors than for hits, more clearcut for high than for low signal rates, and proved significant in both studies after correction for confounding using confounder models of different complexities. Some features of the observed deficit resemble clinical observations in children presenting with attention deficit disorder.
authors.affiliation: Medizinisches Institut für Umwelthygiene, Universität Düsseldorf, F. R. G.
authors.forename: G
authors.initials: G
authors.lastname: Winneke
authors.forename: A
authors.initials: A
authors.lastname: Brockhaus
authors.forename: W
authors.initials: W
authors.lastname: Collet
authors.forename: U
authors.initials: U
authors.lastname: Krämer
mesh_terms: D001519:Behavior / Q000187:drug effects*; D002648:Child; D004781:Environmental Exposure; D005260:Female; D005858:Germany; D006801:Humans; D007855:Lead Poisoning / Q000503:physiopathology*; D008297:Male; D009483:Neuropsychological Tests; D012044:Regression Analysis