title: [Increase in chemiluminescence induced by receptor-independent stimulation of polymorphonuclear cells from psoriatic patients].
abstract: Using a lucigenin-dependent chemiluminescence the authors have measured the "respiratory burst" in polymorphonuclear cells from psoriatic patients and controls. Measurements were performed under stimulation with zymosan, phorbol 12-myristate 13-acetate and latex beads. It has been revealed that the response after stimulation with zymosan increased although there was no significant difference between patients and controls, while the response after stimulation with phorbol 12-myristate 13-acetate and latex beads was significantly increased. Our results suggest an enhanced metabolic activity of polymorphonuclear cells induced by stimuli acting independently from cell-membrane receptors. Therefore an enhanced excitability of polymorphonuclear leukocytes of psoriatic patients is supposed.
authors.forename: E
authors.initials: E
authors.lastname: Battoccoli
authors.forename: M M
authors.initials: MM
authors.lastname: Tappa
authors.forename: O
authors.initials: O
authors.lastname: Simonetti
authors.forename: I
authors.initials: I
authors.lastname: Marchiseppe
authors.forename: M
authors.initials: M
authors.lastname: Valentino
authors.forename: A M
authors.initials: AM
authors.lastname: Offidani
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007840:Latex / Q000494:pharmacology*; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010101:Oxygen Consumption; D011565:Psoriasis / Q000097:blood*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D015054:Zymosan / Q000494:pharmacology*
chemical_list: D007840:Latex; D015054:Zymosan; D013755:Tetradecanoylphorbol Acetate
vernacular_title: Aumento della chemiluminescenza indotta da stimolazione recettore-indipendente nei polimorfonucleati di pazienti psoriasici.