Direct spinal effect of a benzodiazepine (midazolam) on spasticity in man.
The water-soluble benzodiazepine, midazolam, was administered epidurally over the lumbar enlargement 18 times to 9 patients with spasticity due to severe spinal cord injury. Doses of 1.25-3.75 mg produced a rapid decrease of spasticity which lasted 1 h. After the maximal reduction of spasticity, the patients became drowsy. While the results suggest a direct action of midazolam on the spinal cord to reduce spasticity, the effect does not contribute to its usefulness as a therapeutic tool.
Dahm
L S
LS
Division of Restorative Neurology and Human Neurobiology, Baylor College of Medicine, Houston, Tex.
Beric
A
A
Dimitrijevic
M R
MR
Wall
P D
PD
D000328:Adult; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007268:Injections, Epidural; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000627:therapeutic use*; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology; D013119:Spinal Cord Injuries / Q000150:complications
D008874:Midazolam