[Distribution and diagnostic role of COTA in mucinous ovarian tumors].
The localization and diagnostic value of colon-ovarian tumor antigen (COTA) were studied by immunohistochemical S-P method. COTA was found in all 18 cases of mucinous ovarian cystadenocarcinoma (100%) and 3 border line cystadenomas (100%). Yet in 18 cases of ovarian benign mucinous cystadenoma, only 3 were positive (16.6%). These results indicate that COTA is a highly sensitive and specific antigen for mucinous ovarian cystadenocarcinoma and has potential for the early detection of malignant changes in mucinous ovarian cystadenoma.
Shi
Z L
ZL
Fujian Provincial Hospital, Fuzhou.
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D003536:Cystadenocarcinoma / Q000175:diagnosis* / Q000276:immunology; D003537:Cystadenoma / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009093:Mucus / Q000032:analysis; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000276:immunology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; C045043:colon-ovarian tumor antigen, human