Food intake suppressant effect of baclofen in rats.
1. Baclofen given intraperitoneally (i.p.) to rats caused a dose-dependent decrease in food intake. 2. Bicuculline or picrotoxin (GABAA-antagonist) and methergoline (5-HT antagonist) decreased the anorectic effect of baclofen. 3. Pimozide (dopamine receptor blocker), phenoxybenzamine and propranolol (alpha and beta adrenergic blockers) did not diminish the baclofen effect, but even increased the anorexia induced by the drug. 4. It can be postulated that, at least partially, GABAA receptor mechanism, GABA-5HT receptor complex and/or 5-HT mechanism may be involved in baclofen induced anorexia.
Zarrindast
M R
MR
Department of Pharmacology, Faculty of Medicine, University of Tehran, Iran.
Hosseini-Nia
T
T
Allah-Maddadi
S
S
D000818:Animals; D001067:Appetite Depressants; D001418:Baclofen / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001640:Bicuculline / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D010868:Pimozide / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats
D001067:Appetite Depressants; D001418:Baclofen; D001640:Bicuculline; D008711:Metergoline; D010643:Phenoxybenzamine; D010852:Picrotoxin; D010868:Pimozide; D011433:Propranolol