Paecilotoxin production in clinical or terrestrial isolates of Paecilomyces lilacinus strains.
The production of paecilotoxin from various isolates of Paecilomyces lilacinus was studied using three different media and high performance liquid chromatography (HPLC). Alkaline medium was found to be suitable for the production of the toxins. Among 20 strains tested, 19 including four clinical isolates were found to produce the toxins. Production patterns of paecilotoxins were very similar in each strain and the main toxins were A and B.
Mikami
Y
Y
Department of Experimental Chemotherapy, Chiba University, Japan.
Yazawa
K
K
Fukushima
K
K
Arai
T
T
Udagawa
S
S
Samson
R A
RA
D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D006801:Humans; D006863:Hydrogen-Ion Concentration; D003904:Mitosporic Fungi / Q000378:metabolism*; D008969:Molecular Sequence Data; D009183:Mycotoxins / Q000096:biosynthesis*; D010143:Paecilomyces / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D012988:Soil Microbiology
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D003470:Culture Media; D009183:Mycotoxins; D010455:Peptides; C052006:leucinostatin D; C062705:leucinostatin K; C062707:leucinostatin H; C062706:leucinostatin C; C008268:leucinostatin A; C040316:leucinostatin B