Thromboresistant polymers: a new approach.
Selected antithrombotic agents were found to impart improved thromboresistance to polysilicone tubes when covalently bound to such tubes in pilot studies. Bonding was accomplished by radiation grafting of epoxypropyl acrylate monomer on the polysilicone, followed by reaction of the hydroxyl groups of the antithrombotic agents with the epoxy groups on the grafted monomer chains. The bound antithrombotic agents may act by chelating or complexing calcium ions, which are known to perform several functions in blood coagulation.
Wilson
J E
JE
Department of Physiology, Texas College of Osteopathic Medicine, Fort Worth 76107.
Jones
C E
CE
D000179:Acrylates; D000818:Animals; D001769:Blood; D002118:Calcium; D002614:Chelating Agents; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D004852:Epoxy Compounds; D008956:Models, Chemical; D010865:Pilot Projects; D011108:Polymers; D012828:Silicones; D013499:Surface Properties; D013927:Thrombosis / Q000517:prevention & control*
D000179:Acrylates; D002614:Chelating Agents; D004852:Epoxy Compounds; D011108:Polymers; D012828:Silicones; C062422:2,3-epoxypropyl acrylate; D002118:Calcium