Almitrine inhibits breathing movements in fetal sheep in utero.
Whilst hypoxia stimulates fetal peripheral chemoreceptors, fetal breathing movements do not increase as hypoxia also has central effects. We wondered whether specific stimulation of the arterial chemoreceptors by almitrine would produce a stimulation of fetal breathing movements. When almitrine was given to 5 intact and 3 peripherally-chemodenervated fetal sheep in utero, fetal breathing movements rapidly ceased for 1-12 h. There was also a decrease in the amount of time spent in low voltage electrocortical activity. The effects of almitrine are therefore similar to those of hypoxia, and are independent of the peripheral chemoreceptors. Thus it may be a valuable tool in the study of the control of fetal breathing.
Moore
P J
PJ
Department of Biochemistry & Physiology, University of Reading, Whiteknights.
Hanson
M A
MA
Parkes
M J
MJ
D015765:Almitrine / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002628:Chemoreceptor Cells / Q000187:drug effects; D003714:Denervation; D004569:Electroencephalography; D005333:Fetus / Q000502:physiology*; D012119:Respiration / Q000187:drug effects*; D012756:Sheep
D015765:Almitrine