title: Condensed thienopyrimidines. IV. Synthesis and gastric antisecretory activity of 2,3-dihydro-5H-oxazolothienopyrimidine derivatives.
abstract: 2,3-Dihydro-5H-oxazolo[3,2-a]thieno[3,2-d]-(2a--d), [3,4-d]-(2e--h), and [2,3-d]pyrimidine derivatives (2i,j) were synthesized and evaluated for gastric antisecretory activity. These analogues (2) were prepared stepwise starting from formylthiophenecarbamates (4). The structure-activity relationships of these compounds are discussed.
authors.forename: M
authors.initials: M
authors.lastname: Sugiyama
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: K
authors.initials: K
authors.lastname: Tabata
authors.forename: H
authors.initials: H
authors.lastname: Fukumi
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000897:Anti-Ulcer Agents; D010080:Oxazoles; D011743:Pyrimidines; D013876:Thiophenes