Anti-convulsant therapy in eclampsia.
Seventy four patients presented with eclampsia at N.W.M. Hospital. Bombay. Among the patients with eclampsia, 64.9% were primis, 29.7% were gravida II-IV and 5.4% were grand multis. As many as 40.5% patients were less than 20 years of age, while 2.7% were over 30 years of age. 48.7% had antepartum convulsions, 40.5% had intrapartum convulsions, while 8 patients convulsed in the postpartum period. Besides standard management of eclamptic patients, 3 protocols of anticonvulsant therapy were utilised. 27% were managed with diphenyl hydantoin sodium, 43% with magnesium sulphate, and 30% by combination of diazepam and pentazocine. The maternal and perinatal outcome was evaluated. Control of convulsions was superior with magnesium sulphate while perinatal outcome was best with diphenyl hydantoin.
Maheshwari
J R
JR
Desai
S V
SV
Hansotia
M D
MD
Walvekar
V R
VR
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004461:Eclampsia / Q000188:drug therapy* / Q000401:mortality; D005260:Female; D006801:Humans; D007226:Infant Mortality; D008278:Magnesium Sulfate / Q000627:therapeutic use; D008428:Maternal Mortality; D010423:Pentazocine / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use; D011247:Pregnancy
D000927:Anticonvulsants; D010672:Phenytoin; D008278:Magnesium Sulfate; D003975:Diazepam; D010423:Pentazocine