Chromosomal localization of murine interleukin-1 alpha and beta genes.
DNA analyses of mouse X Chinese hamster somatic cell hybrids and of recombinant inbred mouse strains have previously shown that the interleukin-1 alpha and beta genes are tightly linked on murine chromosome 2, approximately 4.7 cM distal to beta-2-microglobulin. In this study, using in situ chromosome hybridization, we show that the two interleukin-1 genes are located in the F region of murine chromosome 2 and discuss this physical map position in relation to conserved genetic linkage groups.
Boultwood
J
J
Leukaemia Research Fund Leukaemogenesis Laboratory, MRC Radiobiology Unit, Chilton, Didcot, United Kingdom.
Breckon
G
G
Birch
D
D
Cox
R
R
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D006224:Cricetinae; D004247:DNA / Q000235:genetics; D005796:Genes; D007375:Interleukin-1 / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D007375:Interleukin-1; D004247:DNA