Hematological and plasma biochemical disturbances in experimental molybdenum toxicosis in sheep.
Two groups of 4 sheep received a daily iv injection of sodium heptamolybdate (100mg/day) or of saline for 2 weeks to study the hematological and plasma biochemical effects of molybdenum toxicosis. In molybdenum-dosed sheep, there was hypercupremia, mild anemia due to the decrease of copper concentration in the liver and moderate hepatocellular damage probably due to a direct toxic effect of molybdenum against the liver.
Auza
N
N
Laboratoire Associe INRA Toxicologie Biochimique et Metabolique, Ecole Nationale Veterinaire, Toulouse, France.
Braun
J P
JP
Benard
P
P
Thouvenot
J P
JP
Rico
A G
AG
D000747:Anemia, Hypochromic / Q000139:chemically induced / Q000662:veterinary; D000818:Animals; D001799:Blood Sedimentation / Q000187:drug effects; D003300:Copper / Q000097:blood; D005260:Female; D005969:Glutamate Dehydrogenase / Q000097:blood; D007064:L-Iditol 2-Dehydrogenase / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008982:Molybdenum / Q000506:poisoning*; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood / Q000139:chemically induced*
D003300:Copper; D008982:Molybdenum; D007064:L-Iditol 2-Dehydrogenase; D007770:L-Lactate Dehydrogenase; D005969:Glutamate Dehydrogenase