[Lipid peroxidation and the status of the antioxidant systems of the blood and liver in isolated and combined action of copper- containing dust and sulfur dioxide].
During the clinical examination of copper smelters the disorders of some body systems were detected. They were assumed to be caused by changes in the ratio of lipid peroxidation and antioxidative body activity. The study of isolated and sulphur dioxide-combined effect of copper dusts on rats revealed that interaction of sulphur dioxide metabolites and metals, contained in dusts, formed a "vicious circle" and reduced protective capacities of antioxidative blood systems and liver, thus giving rise to body accumulation of cytotoxic products of lipid peroxidation.
Beliaev
V S
VS
Shmeleva
L T
LT
D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D003300:Copper / Q000633:toxicity*; D004391:Dust; D004789:Enzyme Activation / Q000187:drug effects; D005978:Glutathione / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D005980:Glutathione Reductase / Q000037:antagonists & inhibitors / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013458:Sulfur Dioxide / Q000633:toxicity*
D000393:Air Pollutants; D000975:Antioxidants; D004391:Dust; D013458:Sulfur Dioxide; D003300:Copper; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione
Izuchenie perekisnogo okisleniia lipidov i sostoianiia antiokis- lite'lnykh sistem krovi i pecheni pri izolirovannom i kombiniro- vannom vozdeĭstvii medsoderzhashcheĭ pyli i dioksida sery.