VIP-mRNA is increased in hypertensive rats.
Vasoactive intestinal peptide (VIP) is a potent vasodilator. We therefore set out to investigate VIP-gene expression in spontaneous hypertensive rats. By quantitative in situ hybridization histochemistry as well as by RNA blot hybridization experiments we discovered a significant increase in VIP transcripts in the brains of those hypertensive rats. We suggest that the increase in VIP-gene expression may play a compensatory role in these rats where otherwise the rise in blood pressure may have had a much more adverse effect.
Avidor
R
R
Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.
Eilam
R
R
Malach
R
R
Gozes
I
I
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005786:Gene Expression Regulation; D006973:Hypertension / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D012333:RNA, Messenger; D014660:Vasoactive Intestinal Peptide