title: Oestrogen receptors in benign epithelial lesions and intraduct carcinomas of the breast: an immunohistological study.
abstract: We examined 198 breast lesions, representing commonly encountered benign epithelial proliferative disorders, lobular carcinoma in situ and intraduct carcinoma, immunohistologically for oestrogen receptors (ER). A mixture of three ER monoclonal antibodies--H222, D75 and D547--was used on sections of routinely processed and paraffin-embedded tissue blocks. Over 65% of the benign and malignant lesions showed some evidence of ER expression and significant staining was recorded by two observers in 28-31% of fibroadenomas, 18-28% of ductal epithelial hyperplasias, 30-40% of sclerosing adenosis cases, 38-45% of papillomas, 60% of in situ lobular carcinomas and 42-45% of intraduct carcinomas. Apocrine metaplastic cells and myoepithelial cells showed absent or only weak staining. Amongst intraduct carcinomas, less than 20% of comedo carcinomas and over 50% of cribriform, papillary and solid variants showed significant ER staining.
authors.affiliation: Department of Pathology, University of Sheffield Medical School, UK.
authors.forename: D D
authors.initials: DD
authors.lastname: Giri
authors.forename: S A
authors.initials: SA
authors.lastname: Dundas
authors.forename: J F
authors.initials: JF
authors.lastname: Nottingham
authors.forename: J C
authors.initials: JC
authors.lastname: Underwood
mesh_terms: D000911:Antibodies, Monoclonal; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D011960:Receptors, Estrogen / Q000378:metabolism*; D012871:Skin Diseases / Q000378:metabolism* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D011960:Receptors, Estrogen