[Participation of the SSB protein in the repair of the DNA of Ehrlich ascites carcinoma cells following UV irradiation].
Synchronous changes were detected in the SSB-protein content of the chromatin and in the rate of repair DNA synthesis at different time intervals after UV-irradiation of Ehrlich ascites tumor cells. The amount of SSB-protein in the extra-chromatin fraction was in an inverse relation to its content in the chromatin, whereas the cumulative SSB-protein content remained invariable. Similar changes in the SSB-protein content of the chromatin and in repair synthesis were also registered after the effect of various doses of UV-light. The increase of the SSB-protein content in the chromatin was not connected with the postirradiation accumulation of single-strand sites in DNA.
Novoradovskaia
N A
NA
Koterov
A N
AN
Filippovich
I V
IV
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D004260:DNA Repair / Q000502:physiology*; D004273:DNA, Neoplasm / Q000528:radiation effects*; D004268:DNA-Binding Proteins / Q000502:physiology*; D066298:In Vitro Techniques; D051379:Mice; D009363:Neoplasm Proteins / Q000502:physiology*; D009368:Neoplasm Transplantation; D014466:Ultraviolet Rays
D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins
Uchastie SSB-belka v reparatsii DNK kletok astsitnoĭ kartsinomy Erlikha posle UF-oblucheniia.