[Diflucortolone-21-valerate Reference Standard (Control 871) of National Institute of Hygienic Sciences].
Diflucortolone-21-valerate was tested for the preparation of "Diflucortolone-21-valerate Reference Standard (Control 871)". Analytical data obtained were as follows: loss on drying, 0.05%; infrared spectrum, 1745, 1727, 1667, 1625, 1611, 1169 cm-1; ultraviolet spectrum, lambda max = 239 nm; absorbance, E1%1cm (239 nm) = 348.8; optical rotation, [alpha]20D: + 100.8 degrees; melting point, 203.2 degrees C; thin-layer chromatography, three contaminants were detected; high-performance liquid chromatography, two contaminants were detected; fluorine, 8.06%. On the basis of those results, this material was authorized as the National Institute of Hygienic Sciences Reference Standard (Control 871).
Tanaka
M
M
Hiroshige
R
R
Murai
M
M
Tokunaga
H
H
Okada
S
S
Kimura
T
T
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004060:Diflucortolone / Q000031:analogs & derivatives* / Q000032:analysis / Q000592:standards; D004340:Drug Contamination; D005448:Fluocortolone / Q000031:analogs & derivatives*; D007564:Japan; D010602:Pharmacopoeias as Topic / Q000592:standards*; D012015:Reference Standards; D013055:Spectrophotometry, Infrared
C013486:diflucortolone valerate; D005448:Fluocortolone; D004060:Diflucortolone