title: Demonstration of A-currents in pancreatic islet cells.
abstract: Voltage-activated K+ currents resistant to TEA but blockable by 4-AP were recorded from mouse pancreatic islet cells. These currents first become observable during depolarizations to voltages more positive than -40 mV, reaching a peak amplitude of 120 +/- 34 pA at +6 mV (n = 4), display rapid turn on (tau = 3.3 +/- 1.1 ms at +6 mV) and inactivate completely within 250 ms (tau = 65 +/- 5 at +6 mV). The current is subject to steady-state inactivation. The midpoint (Vh) of the inactivation curve (h infinity) was observed at -72 +/- 2 mV. The properties of this current resemble those reported for the A-current in neurons.
authors.affiliation: Department of Medical Physics, Gothenburg, Sweden.
authors.forename: P A
authors.initials: PA
authors.lastname: Smith
authors.forename: K
authors.initials: K
authors.lastname: Bokvist
authors.forename: P
authors.initials: P
authors.lastname: Rorsman
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004594:Electrophysiology; D007515:Islets of Langerhans / Q000166:cytology / Q000502:physiology*; D051379:Mice; D015221:Potassium Channels / Q000502:physiology*
chemical_list: D015221:Potassium Channels