Busulfan (Bu) and cyclophosphamide (Cy) for marrow transplantation.
Bu and Cy is a bone marrow transplant preparative regimen that is effective for ANLL and certain genetic diseases. It has shown promise in CML. Its effectiveness in ALL and lymphomas remains to be explored. The substitution of Bu for TBI in marrow transplant regimens would seem to have a number of practical and theoretical advantages.
Santos
G W
GW
Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland.
D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000009:adverse effects / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use*; D005069:Evaluation Studies as Topic; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery; D015470:Leukemia, Myeloid, Acute / Q000601:surgery*; D014411:Neoplastic Stem Cells / Q000187:drug effects; D011300:Preoperative Care; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
D003520:Cyclophosphamide; D002066:Busulfan