title: Use of imipramine in children with intractable asthma and psychiatric disorders: a warning.
abstract: Imipramine is an established treatment for anxiety in adults. Some evidence also exists that it may be beneficial in children. Because of the frequent co-occurrence of anxiety and affective symptomatology in asthmatic children, a pilot study was undertaken to obtain clinical observations on the effects of imipramine on symptoms of asthma as well as those of separation anxiety and depression in children suffering from intractable asthma. The pilot trial was terminated because of medical complications after 6 patients participated.
authors.affiliation: Cleveland Clinic Foundation, Ohio.
authors.forename: A M
authors.initials: AM
authors.lastname: Kanner
authors.forename: R G
authors.initials: RG
authors.lastname: Klein
authors.forename: B
authors.initials: B
authors.lastname: Rubinstein
authors.forename: A
authors.initials: A
authors.lastname: Mascia
mesh_terms: D000293:Adolescent; D001010:Anxiety, Separation / Q000188:drug therapy* / Q000523:psychology; D001249:Asthma / Q000188:drug therapy* / Q000523:psychology; D001993:Bronchodilator Agents / Q000008:administration & dosage; D002648:Child; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D001993:Bronchodilator Agents; D007099:Imipramine