title: [Cloning and structural analysis of cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta].
abstract: The data are presented on the cloning and structural analysis of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta (proIL-1 alpha and proIL-1 beta). The nucleotide sequences of proIL-1 alpha and proIL-1 beta cDNAs have been compared with the sequences published earlier. The nucleotide changes resulting in the aminoacid changes of the protein were not found. Some nucleotide changes were identified within the 3'-nontranslated region of the proIL-1 beta cDNA. The existence of the allelic variants for interleukin genes registered only on the gene level has been supposed.
authors.forename: S V
authors.initials: SV
authors.lastname: Kotenko
authors.forename: M T
authors.initials: MT
authors.lastname: Bulenkov
authors.forename: V P
authors.initials: VP
authors.lastname: Veĭko
authors.forename: S M
authors.initials: SM
authors.lastname: Epishin
authors.forename: I B
authors.initials: IB
authors.lastname: Lomakin
authors.forename: A V
authors.initials: AV
authors.lastname: Emel'ianov
authors.forename: A P
authors.initials: AP
authors.lastname: Kozlov
authors.forename: V G
authors.initials: VG
authors.lastname: Konusova
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Kotov
authors.forename: T V
authors.initials: TV
authors.lastname: Kurbatova
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics*; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics* / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000235:genetics* / Q000494:pharmacology
chemical_list: D007375:Interleukin-1; D011498:Protein Precursors; C043830:interleukin 1 precursor; D004247:DNA
vernacular_title: Klonirovanie i strukturnyĭ analiz kDNK, kodiruiushchikh prointerleĭkin-1 alpha i prointerleĭkin-1 beta cheloveka.