title: Mesencephalic dopamine innervation of the frontoparietal (sensorimotor) cortex of the rat: a microdialysis study.
abstract: Results obtained in a study using an in vivo microdialysis technique show that dopamine is detected in perfusates collected from the frontoparietal (sensorimotor) cortex of control rats (dopamine = 0.7 +/- 0.2 nM, n = 10) or of rats with cortical lesions produced by the neurotoxin kainic acid (0.9 +/- 0.2 nM, n = 4). However, cortical dopamine levels were strongly reduced (0.07 +/- 0.06 nM, n = 4) following deafferentation induced by mesencephalic 6-hydroxydopamine injection. Dopamine levels, but not its metabolites could be increased by local KCl application, supporting the idea that extracellular dopamine collected by microdialysis reflects a pool of releasable neurotransmitter.
authors.affiliation: Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Herrera-Marschitz
authors.forename: M
authors.initials: M
authors.lastname: Goiny
authors.forename: H
authors.initials: H
authors.lastname: Utsumi
authors.forename: U
authors.initials: U
authors.lastname: Ungerstedt
mesh_terms: D000818:Animals; D002541:Cerebral Decortication; D002851:Chromatography, High Pressure Liquid; D003956:Dialysis / Q000379:methods; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D007608:Kainic Acid / Q000502:physiology; D008297:Male; D009044:Motor Cortex / Q000378:metabolism / Q000502:physiology*; D010296:Parietal Lobe / Q000378:metabolism / Q000502:physiology*; D011189:Potassium Chloride / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013238:Stereotaxic Techniques
chemical_list: D011189:Potassium Chloride; D007608:Kainic Acid; D004298:Dopamine