Controlled release of dopamine from a polymeric brain implant: in vivo characterization.
Intracerebral microdialysis was used to evaluate the long-term in vivo release of dopamine from ethylene-vinyl acetate (EVAc)-dopamine copolymer matrix discs for up to 65 days following striatal implantation. Dopamine release occurred through a single cavity present on one side of the disc, which was otherwise fully coated with an additional, impermeable layer of EVAc. At 20 days following implantation of the device, extracellular concentrations of dopamine within the striatum reached micromolar levels, over 200-fold greater than control values. Release of dopamine was shown to be stable and maintained for the 2-month duration of the experiment. Histological examination confirmed the biocompatible nature of the implant. There are potential applications of this technology to the treatment of Parkinson's disease and other neurological and psychiatric disorders.
During
M J
MJ
Department of Pharmacology, Yale University School of Medicine, New Haven, CT.
Freese
A
A
Sabel
B A
BA
Saltzman
W M
WM
Deutch
A
A
Roth
R H
RH
Langer
R
R
D000818:Animals; D001921:Brain / Q000473:pathology; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004343:Drug Implants; D008297:Male; D011108:Polymers; D019736:Prostheses and Implants; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D004343:Drug Implants; D011108:Polymers; D004298:Dopamine