Use of carboplatin in the treatment of testicular cancer.
Recent evidence indicates that carboplatin may be useful in the treatment of various forms of testicular cancer. The results of one study showed that carboplatin was highly effective and well tolerated in patients with previously untreated disseminated seminoma. However, conventional doses of carboplatin appear to be inactive in patients with refractory nonseminoma. Of particular interest are recent results showing that an intensive regimen of carboplatin in combination with etoposide with autologous bone marrow rescue will induce a few complete remissions in heavily pretreated germ cell tumor patients.
Williams
S D
SD
Department of Medicine, Indiana University, Indianapolis 46223.
Nichols
C R
CR
Jansen
J
J
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin; D004341:Drug Evaluation; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D013736:Testicular Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D005047:Etoposide; D016190:Carboplatin