Heteroarylalkanoic acids with possible antiinflammatory activities, Note IX. The binding to human serum albumin.
The interaction of some isosteric and homologues series of antiiflammatory heteroarylalkanoic acids with human serum albumin (HSA) was investigated by UV difference spectroscopy and fluorescence quenching. All tested compounds were shown to bind to HSA. The interaction with surfactants and the linear relationship between binding constants and pKa suggest that electrostatic force is dominant in the binding of these compounds and that the binding site consists of a cationic charge near an hydrophobic surface.
Costantino
L
L
Parenti
C
C
Tait
A
A
Di Bella
M
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D002264:Carboxylic Acids / Q000493:pharmacokinetics*; D006801:Humans; D011485:Protein Binding; D012709:Serum Albumin; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002264:Carboxylic Acids; D012709:Serum Albumin