Half-body radiotherapy in the treatment of canine lymphoma.
In a Phase I-II study, half-body radiotherapy was used to treat 14 dogs with multicentric lymphoma. Using this technique, a radiation dose of 7 Gray (Gy) was delivered to one half of the body in a single exposure. The other half of the body was treated approximately 28 days later. Of 14 treated dogs, 11 (79%) had a measurable decrease in tumor size. Five dogs achieved a complete or partial remission with a mean duration of 102 and 54 days, respectively. In predicting response to therapy, poor prognostic factors included large tumor burdens, advanced disease stage, and chemotherapy-resistant tumors. Side effects of treatment were divided chronologically into acute (radiation sickness, tumor lysis), subacute (bone marrow suppression), and chronic (radiation pneumonitis, lymphoma-cell leukemia) syndromes. Complications were more severe in tumor-bearing dogs when compared with healthy control animals. Dogs with small tumor burdens and minimal internal disease had fewer complications compared with those with more advanced disease.
Laing
E J
EJ
Department of Clinical Studies, Ontario Veterinary College, Guelph, Canada.
Fitzpatrick
P J
PJ
Binnington
A G
AG
Norris
A M
AM
Mosseri
A
A
Rider
W D
WD
Valli
V E
VE
Baur
A
A
D000818:Animals; D004283:Dog Diseases / Q000532:radiotherapy*; D004285:Dogs; D005069:Evaluation Studies as Topic; D005260:Female; D008223:Lymphoma / Q000532:radiotherapy / Q000662:veterinary*; D008297:Male; D012074:Remission Induction; D014916:Whole-Body Irradiation / Q000379:methods / Q000662:veterinary*