The treatment of minocycline-induced brainstem vertigo by the combined administration of piracetam and ergotoxin.
Two randomized studies to test the efficacy of a combination of Piracetam and Ergotoxin on the destabilized brainstem are reported. In the first study, a pharmacological model using Minocycline is employed. A follow-up clinical study analysed the effect of the preparation in 5 patients suffering from vertigo and other related complaints. It was seen that there was a significant improvement in the nystagmus profiles of the pharmacological model volunteers. Similarly, the patient group showed a marked improvement in symptoms, and in orientation capability as tested by Cranio-Corpo-Graphy.
Claussen
C F
CF
Department of Neurootology, University of Würzburg, West Germany.
Schneider
D
D
Patil
N P
NP
D000328:Adult; D001933:Brain Stem; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004873:Ergolines / Q000627:therapeutic use*; D004876:Ergot Alkaloids / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008911:Minocycline / Q000009:adverse effects*; D010889:Piracetam / Q000627:therapeutic use*; D011760:Pyrrolidinones / Q000627:therapeutic use*; D011897:Random Allocation; D013754:Tetracyclines / Q000009:adverse effects*; D014717:Vertigo / Q000139:chemically induced / Q000188:drug therapy*
D004873:Ergolines; D004876:Ergot Alkaloids; D011760:Pyrrolidinones; D013754:Tetracyclines; C100272:ergotoxine; D008911:Minocycline; D010889:Piracetam