title: Chronic recurrent multifocal osteomyelitis. Association with vertebra plana.
abstract: In seven children who had chronic recurrent multifocal osteomyelitis, the radiographic and histological findings were consistent with those of osteomyelitis, but the results of cultures were negative. We studied the clinical, radiographic, histological, and microbiological findings in these patients, who had a total of thirty-nine lesions. The lesions occurred most frequently in the spine, tibia, and femur; three patients had vertebra plana. The natural history of chronic recurrent multifocal osteomyelitis appears to be slow, spontaneous resolution of the osseous lesions without specific treatment. The diagnosis is one of exclusion. Biopsy is recommended, and results of cultures must be negative before therapy with antibiotics can be withheld.
authors.affiliation: Department of Orthopaedic Surgery, Children's Hospital, Boston, Massachusetts 02115.
authors.forename: L
authors.initials: L
authors.lastname: Yu
authors.forename: J R
authors.initials: JR
authors.lastname: Kasser
authors.forename: E
authors.initials: E
authors.lastname: O'Rourke
authors.forename: H
authors.initials: H
authors.lastname: Kozakewich
mesh_terms: D000293:Adolescent; D001431:Bacteriological Techniques; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology*; D002648:Child; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000000981:diagnostic imaging* / Q000382:microbiology / Q000473:pathology; D011859:Radiography; D012008:Recurrence; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology