title: Influence of endothelin on systemic arterial pressure and regional blood flow in the cat.
abstract: Regional vascular responses to endothelin were investigated in the anesthetized cat. I.v. injection of endothelin at 0.1 nmol/kg decreased arterial pressure and renal vascular resistance but increased vascular resistance in the small intestine. At 0.3 nmol/kg i.v. the peptide caused a greater decrease in arterial pressure and increased mesenteric resistance but had no significant effect on renal resistance. In contrast, at 1 nmol/kg i.v. endothelin caused a biphasic change in arterial pressure and marked increases in mesenteric and renal resistance. Injection of the peptide in doses of 0.1-1 nmol/kg i.v. caused only increases in carotid blood flow. These data suggest that responses to endothelin are dependent on dose and vascular bed studied.
authors.affiliation: Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112.
authors.forename: R K
authors.initials: RK
authors.lastname: Minkes
authors.forename: P J
authors.initials: PJ
authors.lastname: Kadowitz
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002339:Carotid Arteries / Q000187:drug effects; D002415:Cats; D016232:Endothelins; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects*; D012077:Renal Artery / Q000187:drug effects; D013552:Swine; D013997:Time Factors
chemical_list: D016232:Endothelins; D010455:Peptides