Decline of circulating immune complexes in rheumatoid arthritis: patients treated with tiopronine.
Fifteen patients with rheumatoid arthritis were treated with tiopronine, a new slow-acting drug, and various serological parameters were assessed before the onset and after two-month treatment. The latex test titres decreased, and there was a significant fall in the levels of IgA-containing circulating immune complexes in parallel with a depletion of plasma complement breakdown products.
Bendaoud
B
B
Delecoeuillerie
G
G
Katsikis
P
P
Le Goff
P
P
Youinou
P
P
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008625:Tiopronin / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000936:Antigen-Antibody Complex; D008625:Tiopronin