[Pulmonary emphysema. Clinical aspects and open questions].
The development of airway obstruction is decisively influenced by the formation of emphysemata. Preventing the formation of emphysemata will have a substantial influence on the progression of obstructive airway diseases. Absolute as well as relative protease excess can be regarded as essential cause for emphysemata. Alpha 1-antitrypsine as significant protease inhibitor in alveolar regions is capable of compensating for a protease imbalance. Processes accompanied by an excess of proteases in the alveolar region should be influenced by adequate alpha 1-antitrypsine substitution to prevent the development of emphysemata. This promising preventive as well as therapeutic principle is apt to be extended and specified.
Ulmer
W T
WT
Schmidt
E W
EW
Schwabl
U
U
D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology; D010447:Peptide Hydrolases / Q000502:physiology*; D011650:Pulmonary Alveoli / Q000503:physiopathology*; D011656:Pulmonary Emphysema / Q000503:physiopathology*; D000515:alpha 1-Antitrypsin / Q000502:physiology
D000515:alpha 1-Antitrypsin; D010447:Peptide Hydrolases
Lungenemphysem. Klinik und offene Fragen.