Synthesis and biological testing of certain 2-(5-substituted-2-thienylthio)benzoic acid derivatives.
The syntesis of a number of 2-(5-substituted-2-thienylthio)benzoic acid derivatives is described. The synthesized compounds were screened for their muscle relaxant and parasympatholytic activities and the results are reported.
Tantawy
A S
AS
Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.
el-Subbagh
H I
HI
el-Ashmawy
M B
MB
el-Emam
A A
AA
D000818:Animals; D001565:Benzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D006827:Hydantoins / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D007422:Intestines / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis*; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000138:chemical synthesis*; D010862:Pilocarpine / Q000494:pharmacology; D011817:Rabbits; D012472:Salivation / Q000187:drug effects; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology
D001565:Benzoates; D006827:Hydantoins; D009125:Muscle Relaxants, Central; D010276:Parasympatholytics; D012545:Schiff Bases; D010862:Pilocarpine; C063961:1-(5-(carboxyphenylthio)-2-thenylideneamino)hydantoin