title: Increased accumulation of N-isopropyl-p-(123I)-iodoamphetamine in two cases with mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS).
abstract: We present two cases with mitochondrial encephalopathy with lactic acidosis and strokelike episodes (MELAS), which showed both increased and decreased accumulation of N-isopropyl-p-(123I)-iodoamphetamine (123I-IMP) in single photon emission computed tomography (SPECT). The increased accumulation of the tracer occurred, before low density appeared on conventional computed tomography, suggesting that 123I-IMP SPECT may be useful in pathophysiological study of MELAS.
authors.affiliation: Department of Nuclear Medicine, Kawasaki Medical School, Okayama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Morita
authors.forename: S
authors.initials: S
authors.lastname: Ono
authors.forename: M
authors.initials: M
authors.lastname: Fukunaga
authors.forename: T
authors.initials: T
authors.lastname: Yasuda
authors.forename: Y
authors.initials: Y
authors.lastname: Higashi
authors.forename: A
authors.initials: A
authors.lastname: Terao
authors.forename: R
authors.initials: R
authors.lastname: Morita
mesh_terms: D000140:Acidosis, Lactic / Q000150:complications*; D000328:Adult; D000662:Amphetamines; D001921:Brain / Q000648:ultrastructure; D001927:Brain Diseases / Q000000981:diagnostic imaging*; D002561:Cerebrovascular Disorders / Q000150:complications*; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D008931:Mitochondria, Muscle; D013702:Temporal Lobe; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine