Granulocytic macrophage colony stimulating factor restores in vitro growth of granulocyte-macrophage bone marrow hematopoietic progenitors in dyskeratosis congenita.
In vitro 14-day cultures of bone marrow from a patient with dyskeratosis congenita showed virtually no growth of colonies. The addition of recombinant granulocyte-macrophage colony stimulating factor (rGM-CSF) promoted a significant increase in the number of GM colonies (CFU-GM). Interleukin 3 also increased GM colony formation but to a lesser extent. GM-CSF may have a therapeutic implication for pancytopenia in dyskeratosis congenita.
Michalevicz
R
R
Institute of Hematology, Ichilov Hospital, Tel Aviv Medical Center, Israel.
Baron
S
S
Nordan
U
U
Rahmani
R
R
D000328:Adult; D001853:Bone Marrow / Q000187:drug effects; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007972:Leukoplakia, Oral; D008297:Male; D009264:Nails, Malformed; D010198:Pancytopenia / Q000097:blood* / Q000235:genetics; D010859:Pigmentation Disorders; D013577:Syndrome; D014062:Tongue Neoplasms
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016178:Granulocyte-Macrophage Colony-Stimulating Factor