Carbimazole-induced acute cholestatic hepatitis.
A case of carbimazole-induced cholestatic hepatitis is presented. A woman received carbimazole for hyperthyroidism for 3 months. Five months later, she had prompt recurrence of cholestasis parameters after rechallenge (2 days of treatment). Histologic examination showed predominantly centrilobular cholestasis. Only 5 other cases have been published in the literature. An idiosyncratic mechanism seems likely.
Ozenne
G
G
Clinique Thérapeutique, C.H.U. de Rouen, France.
Manchon
N D
ND
Doucet
J
J
Hémet
J
J
Schrub
J C
JC
Bercoff
E
E
D000208:Acute Disease; D000368:Aged; D002231:Carbimazole / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D002779:Cholestasis / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006111:Graves Disease / Q000188:drug therapy; D006801:Humans; D008099:Liver / Q000473:pathology
D002231:Carbimazole