Mutagenicity of expectorate from workers in a coke plant.
Methanol extracts of hydrolyzed expectorate samples from workers in a coke plant were tested with the Salmonella reversion assay. The expectorates from exposed smokers (but also to a certain extent from exposed non-smokers) were mutagenic; however, the control samples from both smokers and non-smokers were not. The positive results produced by the expectorate samples from exposed smokers suggest a synergistic relationship between exposure to air pollution in the working atmosphere and smoking.
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Department of Botany, University of Trondheim, Norway.
D000395:Air Pollutants, Occupational / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D003031:Coal; D003077:Coke; D006801:Humans; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000235:genetics; D012907:Smoking / Q000009:adverse effects; D013183:Sputum / Q000032:analysis
D000395:Air Pollutants, Occupational; D003031:Coal; D003077:Coke