title: Insulin binding to erythrocytes and fatty acid composition of erythrocyte membrane phospholipids in healthy men.
abstract: The relationship between specific insulin binding to insulin receptors on erythrocytes and erythrocyte membrane phospholipid fatty acid pattern was evaluated in 11 healthy men. A significant negative correlation between insulin binding and the proportion of w-6 family essential fatty acids, especially linoleic acid (r = -0.82, p less than 0.01) and arachidonic acid (r = -0.73, p less than 0.05) in erythrocyte membrane was found. On the other hand significant positive correlation between insulin binding and the content of nonessential fatty acids (r = +0.65, p less than 0.05) was seen. Data presented support the hypothesis that the fatty acid composition of membrane phospholipids may modify properties of insulin receptors.
authors.affiliation: Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia.
authors.forename: T
authors.initials: T
authors.lastname: Pelikánová
authors.forename: M
authors.initials: M
authors.lastname: Kohout
authors.forename: J
authors.initials: J
authors.lastname: Hilgertová
authors.forename: J
authors.initials: J
authors.lastname: Rase
authors.forename: I
authors.initials: I
authors.lastname: Farská
authors.forename: J
authors.initials: J
authors.lastname: Válek
mesh_terms: D000328:Adult; D001095:Arachidonic Acids / Q000097:blood; D004910:Erythrocyte Membrane / Q000032:analysis*; D004912:Erythrocytes / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008041:Linoleic Acids / Q000097:blood; D008297:Male; D008563:Membrane Lipids / Q000097:blood*; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood*; D011972:Receptor, Insulin / Q000502:physiology
chemical_list: D001095:Arachidonic Acids; D005227:Fatty Acids; D007328:Insulin; D008041:Linoleic Acids; D008563:Membrane Lipids; D010743:Phospholipids; D011972:Receptor, Insulin