title: [71 cases of osteosarcoma].
abstract: Seventy one cases of pathologically proven osteosarcoma treated in our hospital from 1961 to 1986 are reported. There were 53 men and 18 women with a ratio of 2.9:1. Peak ages ranged from 11 to 25 in 52 (73.2%) cases. The mean age was 23 years. The most frequent site was the lower end of femur and upper end of tibia (48/70, 68.6%). Local pain and tenderness, which occurred in the early stage and aggravated at night in moderate and advanced stages. Codman's triangle and bone spicule formation in the roentgenograph, increased alkaline phosphatase (AKP) were the most common findings. Under optical microscope reliable diagnosis could only depend upon tumor cells forming osteoid substances, especially, tumorous bone-formation. Under electron microscope, the important findings were the dilated rough surface endoplastic reticulum and large amount of glycogen storage in the cytoplasm. The increased AKP and mildly or moderately positive acid phosphatase might be valuable. The prognosis was favorable in the younger than the older patients over 55 years, on the right than left in tumor site, smaller than larger in tumor size, osteoblast type than the others. Grading showed no significant relation to prognosis. It is emphasized to obtain multiple samples from various sites of the same tumor for precise diagnosis and classification.
authors.affiliation: General Hospital, Beijing Command, PLA.
authors.forename: D Z
authors.initials: DZ
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000032:analysis; D001859:Bone Neoplasms / Q000473:pathology; D002648:Child; D005260:Female; D005266:Femoral Neoplasms / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000473:pathology; D011379:Prognosis; D013977:Tibia
chemical_list: D000469:Alkaline Phosphatase