Immunohistologic findings and results of treatment with cyclosporine in ligneous conjunctivitis.
Using immunohistochemical techniques, we studied ligneous conjunctival lesions from two patients. A significant immune reaction was detected that was characterized by activated T lymphocytes and focal accumulation of plasma cells and B lymphocytes. Immunofluorescent studies demonstrated that IgG was a prominent component of the amorphous hyaline material seen in these lesions. After previous treatment methods had failed, both patients were treated with excisional biopsy and topical cyclosporine. Patient 1 had a dramatic response, with complete resolution of the lesions. Patient 2 had a significant improvement resulting in small, slow-growing recurrences instead of the rapid and extensive recurrences that occurred before treatment with cyclosporine.
Holland
E J
EJ
Department of Ophthalmology, University of Minnesota, Minneapolis 55455.
Chan
C C
CC
Kuwabara
T
T
Palestine
A G
AG
Rowsey
J J
JJ
Nussenblatt
R B
RB
D000328:Adult; D002675:Child, Preschool; D003228:Conjunctiva / Q000473:pathology; D003231:Conjunctivitis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008214:Lymphocytes / Q000145:classification / Q000473:pathology
D003524:Cyclosporins