Altered ultrastructure of lactating rat mammary epithelial cells induced by chronic ethanol ingestion.
The ethanol and acetaldehyde uptake by the lactating rat mammary gland as well as their effects on this gland at the ultrastructural level have been studied. The extraction of acetaldehyde was greater than that of ethanol both after chronic and acute ethanol treatment. Chronic ethanol administration resulted in a loss of the mammary cell polarization, in a reduction of the Golgi dictyosomal elements and in several abnormalities at the level of casein maturation and secretion, whereas lipid synthesis and secretion did not seem to be affected. Normal spherical casein micelles took on a filament-like structure and casein vesicles appeared fused together forming macrovesicles. All these alterations were specific of ethanol and/or acetaldehyde action and were not due to the associated malnutrition, as deduced from the lack of visible effects in the nutritional control group.
Vilaró
S
S
Departamento de Bioquímica y Fisiologia, Facultad de Biologia, Universidad de Barcelona, Spain.
Viñas
O
O
Remesar
X
X
D000079:Acetaldehyde / Q000493:pharmacokinetics; D000437:Alcoholism / Q000473:pathology*; D000818:Animals; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D000431:Ethanol / Q000493:pharmacokinetics; D005260:Female; D007774:Lactation / Q000187:drug effects*; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000473:pathology; D008854:Microscopy, Electron; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol; D000079:Acetaldehyde