title: [Yersinia enterocolitica infections and thalassemia major in children].
abstract: We report two cases of severe Yersinia enterocolitica infection in children with homozygous thalassemia. One patient had septicemia and the other had mesenteric adenitis. Two factors can enhance the infectivity of Yersinia enterocolitica in children with thalassemia: iron overload and deferoxamine therapy. Laparotomy and cefotaxime-netilmicin therapy were successful in the patient with mesenteric adenitis. In the patient with septicemia, cefotaxime-netilmicin, then doxycycline-netilmicin failed, and recovery was finally achieved under rifampicin-netilmicin. Because of the possibility of septicemic dissemination secondary to digestive Yersinia enterocolitica infection in children with thalassemia, we advocate immediate discontinuation of deferoxamine and prescription of oral antimicrobial therapy (trimethoprim-sulfamethoxazole for instance) in every thalassemic patient with febrile diarrhea.
authors.forename: R
authors.initials: R
authors.lastname: Chirio
authors.forename: A
authors.initials: A
authors.lastname: Collignon
authors.forename: L
authors.initials: L
authors.lastname: Sabbah
authors.forename: H
authors.initials: H
authors.lastname: Lestradet
authors.forename: J C
authors.initials: JC
authors.lastname: Torlotin
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D013789:Thalassemia / Q000150:complications*; D015009:Yersinia Infections / Q000150:complications* / Q000188:drug therapy; D015008:Yersinia enterocolitica
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Infections à Yersinia enterocolitica et thalassémie majeure chez l'enfant.