Reduced leucine catabolism induced by chemotherapy in leukemic children.
Five normal children, four children on chemotherapy, and two children who had completed chemotherapy within a year were studied using 13C-leucine breath test. 13C-Leucine was administered on an empty stomach and a single breath was collected sequentially over 3 h. The cumulative dose of 13C in expired gas was measured and found to be lower in children who had had chemotherapy than in the normal children. These results suggest that chemotherapy may lead to a reduction in leucine catabolism.
Kibirige
M S
MS
Department of Oncology, Royal Manchester Children's Hospital, Pendlebury, England.
Morris Jones
P H
PH
Stevens
R F
RF
Rennie
M J
MJ
D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007930:Leucine / Q000378:metabolism*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000378:metabolism
D000970:Antineoplastic Agents; D007930:Leucine