Cerebrospinal fluid beta 2 microglobulin in patients infected with human immunodeficiency virus.
We prospectively evaluated CSF concentrations of beta 2 microglobulin (beta 2M) in 65 human immunodeficiency virus type 1 seropositive patients. The highest concentrations occurred in those with lymphoma, neurologic opportunistic infections, and acquired immune deficiency syndrome dementia complex (ADC). There was a high correlation between the CSF beta 2M concentration and ADC severity, suggesting that CSF beta 2M may be useful as a marker for the development, progression, and perhaps response to treatment of ADC. Elevated CSF beta 2M was not due to CSF pleocytosis and was usually independent of blood-brain barrier dysfunction.
Brew
B J
BJ
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY.
Bhalla
R B
RB
Fleisher
M
M
Paul
M
M
Khan
A
A
Schwartz
M K
MK
Price
R W
RW
D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid* / Q000150:complications / Q000473:pathology; D001812:Blood-Brain Barrier; D003704:Dementia / Q000150:complications; D006801:Humans; D009994:Osmolar Concentration; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid*
D001613:beta 2-Microglobulin