Ultrastructure of epithelial cells in rat's epididymal caput in experimental hyperprolactinemia induced by metoclopramide.
The aim of the performed studies has been to find out wether or not the ultrastructural alterations of the epithelial cells in the rat's epididymal caput occur in hyperprolactinemia induced by metoclopramide and to see if the observed changes are of reversible character. It has been revealed that prolactin concentration was twice as high as in control animals due to peritoneal administration of metoclopramide in a dose of 2.2 mg/kg body mass, given for 14 days. The ultrastructural alterations in the principal cells of epididymal caput affected cellular organelles being involved in proteins synthesis, glycosylation, secretion as well as energetic processes. They were manifested by decreased amount of rough endoplasmic reticulum, widening of its cisternae combined with degranulation, distension of Golgi apparatus cisternae, elevated number of vesicles in apical part of the cells, and changes in mitochondria. The termination of metoclopramide administration made prolactin concentration exhibit values being almost similar to those determined in control rats, whereas the ultrastructural changes in the principal cells were found to be reversible.
Laszczyńska
M
M
Department of Histology and Embryology, Pomeranian Academy of Medicine, Szczecin, Poland.
Rózewicka
L
L
Lubiński
J
J
D000818:Animals; D004822:Epididymis / Q000503:physiopathology / Q000648:ultrastructure*; D006966:Hyperprolactinemia / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D008787:Metoclopramide; D051381:Rats; D011919:Rats, Inbred Strains
D008787:Metoclopramide