Cellular and molecular biology of Alzheimer's disease.
Alzheimer's disease results from the degeneration of neurons. Degenerating nerve cells express atypical proteins, and amyloid is deposited. We suggest that some of these events are strongly influenced by genetic factors and age. Animal models should be useful in investigating the pathogenic mechanisms that lead to the brain abnormalities seen in this disease.
Price
D L
DL
Koo
E H
EH
Unterbeck
A
A
D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D009474:Neurons / Q000502:physiology