Inhibition of tumor cell proliferation by a novel growth regulator from placenta: modulation of membrane phosphorylation and oncogene expression.
The tumor specific inhibition of thymidine uptake by a negative growth regulator isolated from the maternal part of the bovine placenta is in concert with an inhibited expression of ras oncogenes. The results indicate that primary processing is blocked in case of Ha-ras, while a lower transcription rate or a stimulated degradation of mRNA is more likely for N-ras. These reactions are preceded by a specific binding of the inhibitor to tumor cell surface membranes. A modulated phosphate incorporation into some of the surface components is observed as a result of the binding process.
Csaikl
U
U
Institute for Applied and Experimental Oncology, University of Vienna, Austria.
Csaikl
F
F
Letnansky
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004259:DNA-Directed DNA Polymerase / Q000096:biosynthesis; D011905:Genes, ras; D006131:Growth Inhibitors / Q000494:pharmacology*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D010766:Phosphorylation; D010920:Placenta / Q000032:analysis*; D010926:Placental Hormones / Q000494:pharmacology*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011916:Rats, Inbred F344
D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D008565:Membrane Proteins; D010926:Placental Hormones; D012333:RNA, Messenger; C058985:decidua inhibitory factor; D004259:DNA-Directed DNA Polymerase