title: [Properties and activation mechanism of neutrophilic leukocytes].
abstract: The mechanism of neutrophil activation by chemotactic receptor agonists was studied by monitoring stimulus-induced changes in the cytosolic free calcium concentration and hydrogen peroxide formation during the respiratory burst. Two receptor-dependent signal transduction sequences were identified. One sequence depends on calcium, phospholipase C and protein kinase C, and is rate limiting, while the other is comparatively fast and appears to be calcium-independent. The present studies indicate that both sequences must act in concert to transduce receptor-mediated signals and to activate the NADPH oxidase.
authors.affiliation: Theodor-Kocher-Institut, Universität Bern, Schweiz.
authors.forename: M
authors.initials: M
authors.lastname: Baggiolini
authors.forename: D A
authors.initials: DA
authors.lastname: Deranleau
authors.forename: B
authors.initials: B
authors.lastname: Dewald
authors.forename: M
authors.initials: M
authors.lastname: Thelen
authors.forename: V
authors.initials: V
authors.lastname: von Tscharner
authors.forename: M P
authors.initials: MP
authors.lastname: Wymann
mesh_terms: D000818:Animals; D006801:Humans; D008213:Lymphocyte Activation; D009504:Neutrophils / Q000502:physiology*
vernacular_title: Eigenschaften und Aktivierungsmechanismus des neutrophilen Leukozyten.