[Substitution of F XIII concentrate in ulcerative colitis].
A 33 years old female with ulcerative colitis was admitted with an acute exacerbation of the disease characterised by haematochezia, diarrhoea (10 stools/die) and anaemia (haemoglobin 6.5 g/dl). Therapy with 5-ASA and corticosteroids for six weeks failed to decrease the activity of the disease. Since deficiency of coagulation factor XIII (activity 60%, subunit A 56%) was present, in addition, concentrates of factor XIII (Fibrogammin HS, Behring, F.R.G.) 1250 U/die were given for ten days. The substitution resulted in an immediate increase of reduced F XIII activity (164%) and F XIII subunit A (333%) as well as in a marked improvement of symptoms.
Lorenz
R
R
II. Medizinische Klinik und Poliklinik, Technischen Universität München.
Clemens
R
R
Karl
M
M
Classen
M
M
D000328:Adult; D001780:Blood Coagulation Tests; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000628:therapy*; D003131:Combined Modality Therapy; D005176:Factor XIII / Q000627:therapeutic use*; D005177:Factor XIII Deficiency / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D014463:Ultrasonography
D005176:Factor XIII
Substitution von F XIII-Konzentrat bei Colitis ulcerosa.