[Effect of cerebral noradrenaline and dopamine depletion on spontaneous and amphetamine-stimulated motor activity in rats].
Selective depletion of rat brain noradrenaline and dopamine by 6-hydroxidopamine, 30-60 days after cisterna magna microinjection, reduced nocturnal spontaneous locomotor activity by 40%. This treatment also reduced by 90% the excitatory effect of amphetamine on locomotion. Disulfiram and FLA-63, selective inhibitors of dopamine-B-hydroxilase, depleted by 70% the noradrenaline content of striatum and brain cortex, without changes of dopamine concentration in the same areas. These rats showed a reduced spontaneous locomotor activity and a blockade of amphetamine stimulating activity. In conclusion, our results give support to the hypothesis of brain noradrenaline having a major role on the control of locomotor activity of rodents.
Romero Vecchione
E
E
Saturno
N
N
Campos
H A
HA
D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; D004221:Disulfiram; D004298:Dopamine / Q000502:physiology*; D018492:Dopamine Antagonists; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D000662:Amphetamines; D018492:Dopamine Antagonists; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; D004221:Disulfiram; D004298:Dopamine; D009638:Norepinephrine
Efecto del agotamiento de la noradrenalina y dopamina cerebrales de la rata sobre la actividad locomotriz espontanea y la estimulada por anfetamina.