The effect of chronic antihypertensive therapy on the index of left ventricular mass in patients with essential hypertension.
M-mode echocardiography was used in 80 patients with essential hypertension to study changes in the index of left ventricular mass during treatment over 3 years with reserpine, prazosin, indapamide and atenolol, separately or in combination. Forty patients completed a follow-up period of 36 months, while 5 patients died during this period. In all 5 groups, the index of left ventricular mass decreased significantly from the baseline after 1 and 3 years of treatment, except in those patients receiving prazosin in which there was no significant difference in the index of left ventricular mass between 1 and 3 years of treatment. Our results confirm that effective treatment of blood pressure results in a significant reduction in the index of left ventricular mass. Furthermore, this reduction was seen with all modes of treatment and suggests that it was reduction of blood pressure rather than any specific pharmacological property of the drugs that was of major importance.
Komsuoğlu
B
B
Department of Cardiology, Karadeniz Technical University, Medical School, Trabzon, Turkey.
Ozgür
O
O
Duman
E L
EL
Komsuoğlu
S S
SS
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001262:Atenolol / Q000627:therapeutic use; D002306:Cardiac Volume / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy*; D007190:Indapamide / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000627:therapeutic use; D011897:Random Allocation; D012110:Reserpine / Q000627:therapeutic use
D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D001262:Atenolol; D012110:Reserpine; D007190:Indapamide; D011224:Prazosin