Nephrotic syndrome associated with transitional cell carcinoma of the bladder.
We describe the occurrence of a nephrotic syndrome in association with transitional cell carcinoma of the bladder. The proteinuria disappeared several weeks after removal of the tumor. Light and electron microscopy were compatible with a minimal-change lesion, but immunofluorescence showed linear immunoglobulin deposition. Immunoglobulins eluted from the tumor reacted specifically with the kidney and vice versa. We conclude that antibody formation against a specific component of basement membrane common to both kidney and tumor gave rise to the nephropathy in this case.
Rapoport
J
J
Department of Nephrology, Soroka Medical Center, Beersheva, Israel.
Kuperman
O
O
Gopas
Y
Y
Maor
E
E
Eyal
A
A
Mostovslavski
M
M
Abuful
A
A
Chaimovitz
C
C
D001706:Biopsy; D002295:Carcinoma, Transitional Cell / Q000150:complications*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000150:complications*