[AL amyloidosis and primary fibrinolysis. Study of the mechanism of fibrinolysis].
A 45 years old woman with AL amyloidosis presented with a hypofibrinogenemia (fibrinogen 100 mg/dl) without severe bleeding. There was laboratory evidence of fibrinolysis with shortened euglobulin lysis time, decreased alpha-2 plasmin inhibitor and decreased plasminogen. The mechanism of this primary fibrinolysis remains unclear, since there is no enhancement of the tissue-type plasminogen activator. Analysis of the 8 cases related in the literature of excessive fibrinolysis associated with amyloidosis demonstrated improvement of bleeding manifestations and abnormal fibrinolysis following the administration of antifibrinolytic agents.
Boudes
P
P
Service de Médecine Interne, Hôpital Pitié-Salpêtrière, Paris.
Horellou
M H
MH
Bletry
O
O
Bendetowicz
A V
AV
Nguyen
G
G
Conard
J
J
Vidal
E
E
Godeau
P
P
Samama
M
M
D000682:Amyloid; D000686:Amyloidosis / Q000503:physiopathology*; D005260:Female; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D008875:Middle Aged
D000682:Amyloid; C035222:amyloid protein AL
Amylose AL et fibrinolyse primaire. Etude du mécanisme de la fibrinolyse.