Lymphocytes treated with natural alfa-interferon produce a chemotactic factor for human neutrophils.
Lymphocytes stimulated with alfa-interferon released a chemotactic factor for neutrophils. The process was not inhibited by cycloheximide, whereas mepacrine completely inhibited release of the chemotactic activity. The chemotactic factor was resistant to storage, heat treatment and proteolysis. Recombinant alfa-interferon did not stimulate lymphocytes to release a neutrophil chemotactic factor.
Spisani
S
S
Istituto di Chimica Biologica, Università di Ferrara, Italy.
Gavioli
R
R
Chiozzi
P
P
Lanza
F
F
Bortolotti
F
F
Traniello
S
S
D002478:Cells, Cultured; D002630:Chemotactic Factors / Q000096:biosynthesis* / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte; D003470:Culture Media; D003513:Cycloheximide / Q000494:pharmacology; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D016209:Interleukin-8; D008214:Lymphocytes / Q000378:metabolism*; D009504:Neutrophils / Q000502:physiology*; D011796:Quinacrine / Q000494:pharmacology; D011994:Recombinant Proteins
D002630:Chemotactic Factors; D003470:Culture Media; D007370:Interferon Type I; D016209:Interleukin-8; D011994:Recombinant Proteins; D003513:Cycloheximide; D011796:Quinacrine