Hypercalcemia and vitamin D metabolism in Hodgkin's disease. Is there an underlying immunoregulatory relationship?
Hypercalcemia is not common in Hodgkin's disease, but in reported cases is often unassociated with bone involvement. A case is presented demonstrating a mechanism involving elevated levels of 1,25-dihydroxy vitamin D3 (calcitriol). Similar cases in the literature are reviewed. Data implicating calcitriol as a hematolymphoid regulatory hormone are discussed as they may relate to lymphomas, leukemias, and paraneoplastic lymphocyte and monocyte/macrophage activity.
Rieke
J W
JW
Donaldson
S S
SS
Horning
S J
SJ
D000293:Adolescent; D002117:Calcitriol / Q000502:physiology*; D006689:Hodgkin Disease / Q000150:complications / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D008297:Male; D009384:Paraneoplastic Endocrine Syndromes / Q000276:immunology / Q000378:metabolism*
D002117:Calcitriol