title: Ultrasonographically determined thyroid size in pregnancy and post partum: the goitrogenic effect of pregnancy.
abstract: Thyroid function and ultrasonographically determined thyroid volume were investigated at regular intervals during pregnancy and the first postpartum year in 20 women without thyroid autoantibodies. Serum total thyroxine and total triiodothyronine levels were increased and free thyroxine index and free triiodothyronine index levels were decreased, whereas serum thyrotropin level was unaltered during pregnancy when compared with postpartum levels. Thyroid volume was increased during pregnancy with a mean variation of 30% between maximum values (24.1 +/- 2.2 ml, mean +/- SEM, thirty-sixth week of pregnancy) and minimum values (18.4 +/- 2.0 ml, 12 months post partum) (p less than 0.01). In conclusion, our study demonstrates a goitrogenic effect of pregnancy unexplained by alterations in thyroid function variables.
authors.affiliation: Department of Obstetrics and Gynaecology, Gentofte Hospital, Copenhagen, Denmark.
authors.forename: N G
authors.initials: NG
authors.lastname: Rasmussen
authors.forename: P J
authors.initials: PJ
authors.lastname: Hornnes
authors.forename: L
authors.initials: L
authors.lastname: Hegedüs
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D006042:Goiter / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008137:Longitudinal Studies; D009929:Organ Size; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D011644:Puerperal Disorders / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D013961:Thyroid Gland / Q000276:immunology / Q000473:pathology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood; D014463:Ultrasonography
chemical_list: D001323:Autoantibodies; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine