Estimating equivalent human concentrations of no observed adverse effect levels: a comparison of several methods.
Four methods for intra- and inter-species dose extrapolation for inhalation reference doses are discussed. Dichloromethane is used as an example to illustrate quantitative differences in the methods. The methods include a procedure recommended by the U.S. EPA in 1980, 2 approaches to using physiologically-based pharmacokinetic (PB-PK) models that depend on the extent of knowledge of the values of physiological parameters, and a proposed method based on the concepts inherent to PB-PK models but requiring significantly less data on physiological parameters.
Overton
J H
JH
Environmental Criteria and Assessment Office MD-52, US Environmental Protection Agency, Research Triangle Park, NC 27711.
Jarabek
A M
AM
D000280:Administration, Inhalation; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000502:physiology; D008752:Methylene Chloride / Q000008:administration & dosage / Q000009:adverse effects; D008954:Models, Biological; D014481:United States; D014484:United States Environmental Protection Agency
D008752:Methylene Chloride