title: Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. I: The cytochrome P-450 dependent monooxygenase system.
abstract: The effects of long-term caloric restriction on the hepatic cytochrome P-450 dependent monooxygenase system were investigated in the 22-month-old Fischer 344 rat. Caloric restriction decreased the age-related changes in hepatic testosterone metabolism, which are associated with demasculinization of the liver. Caloric restriction also increased hepatic microsomal testosterone 6 beta-hydroxylase, lauric acid 12-hydroxylase and 4-nitrophenol hydroxylase activities over corresponding values in both ad libitum fed 22-month and 60-day-old control male rats. This suggests that cytochrome P-450 isozymes, P-450 pcn1&2, P-452 and P450j may be induced by caloric restriction. Such changes in cytochrome P-450 isozyme profiles could result in altered carcinogen activation, radical formation or drug detoxication in the calorically restricted rat.
authors.affiliation: Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079.
authors.forename: J E
authors.initials: JE
authors.lastname: Leakey
authors.forename: H C
authors.initials: HC
authors.lastname: Cunny
authors.forename: J
authors.initials: J
authors.lastname: Bazare
authors.forename: P J
authors.initials: PJ
authors.lastname: Webb
authors.forename: R J
authors.initials: RJ
authors.lastname: Feuers
authors.forename: P H
authors.initials: PH
authors.lastname: Duffy
authors.forename: R W
authors.initials: RW
authors.lastname: Hart
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D002149:Energy Intake; D008658:Inactivation, Metabolic; D007527:Isoenzymes / Q000378:metabolism; D008017:Life Expectancy; D008099:Liver / Q000201:enzymology*; D008297:Male; D010105:Oxygenases / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D007527:Isoenzymes; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases