Expression of c-myc proto-oncogene in normal human intestinal epithelium.
We studied the expression of the human c-myc proto-oncogene in normal human colon epithelium by both in situ hybridization and immunohistochemistry. c-myc was found to be expressed uniformly throughout the entire thickness of the colon epithelium. The present findings do not support the contention that the c-myc proto-oncogene is primarily expressed in proliferating intestinal epithelial cell compartments.
ten Kate
J
J
Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Eidelman
S
S
Bosman
F T
FT
Damjanov
I
I
D002455:Cell Division; D003106:Colon / Q000032:analysis / Q000166:cytology / Q000378:metabolism; D004847:Epithelial Cells; D004848:Epithelium / Q000032:analysis / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000032:analysis / Q000166:cytology / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger / Q000032:analysis
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger