[Phase II clinical study of LC9018 on carcinomatous peritonitis of gastric cancer. Subgroup for Carcinomatous Peritonitis, Cooperative, Study Group of LC9018].
Using patients with carcinomatous peritonitis caused by gastric cancer, we conducted a Phase II clinical study of LC 9018 by administering the agent alone or in combination with mitomycin C (MMC). Out of 29 patients enrolled, 12 were treated with LC 9018 alone and 17 others with LC 9018 + MMC. Of these, 15 cases were found completely evaluable. The response rate for 15 complete cases against carcinomatous peritonitis was 60.0% (3/5) for the group treated with LC9018 alone and 70.0% (7/10) with LC9018 + MMC. Of the 27 eligible patients, the ascites could be controlled in 58.3% (7/12) for those treated with LC9018 alone and 60.0% (9/15) for those with LC9018 + MMC, with tumor cells being eliminated in 50.0% (6/12) and 60.0% (9/15), respectively. Major adverse reactions included fever, nausea/vomiting, abdominal pain and increases in GOT and GPT. These findings suggest that LC9018 might be a useful therapeutic agent against carcinomatous peritonitis of gastric cancer whether used alone or in combination with MMC.
Okamura
T
T
Maehara
Y
Y
Sugimachi
K
K
D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D001201:Ascites / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007564:Japan; D007780:Lacticaseibacillus casei; D008297:Male; D008875:Middle Aged; D008937:Mitomycins / Q000627:therapeutic use; D015337:Multicenter Studies as Topic; D010538:Peritonitis / Q000209:etiology / Q000628:therapy*; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology
D000276:Adjuvants, Immunologic; C048475:LC 9018; D008937:Mitomycins