Participation of the complement system in ischemia/reperfusion injury.
Reperfusion of ischemic skeletal muscle is associated with an early infiltration of WBC, a process mediated by locally generated chemotactic factors. We present evidence that selective activation of the alternative complement cascade occurs in response to skeletal muscle ischemia/reperfusion injury. Complement activation may result in the generation of peptides which are chemotactic for neutrophils, and the formation of molecular complexes which injure cell membranes.
Rubin
B
B
Division of Vascular Surgery, R. Fraser Elliott Vascular Research Laboratory, University of Toronto, Ontario, Canada.
Smith
A
A
Romaschin
A
A
Walker
P
P
D000818:Animals; D002462:Cell Membrane / Q000473:pathology; D002630:Chemotactic Factors / Q000378:metabolism; D002634:Chemotaxis, Leukocyte; D003167:Complement Activation; D003181:Complement C4 / Q000032:analysis; D011415:Complement Factor B / Q000032:analysis; D003170:Complement Pathway, Alternative; D004285:Dogs; D006614:Hindlimb / Q000098:blood supply; D007249:Inflammation; D007511:Ischemia / Q000503:physiopathology; D009504:Neutrophils / Q000473:pathology*; D015427:Reperfusion Injury / Q000503:physiopathology*
D002630:Chemotactic Factors; D003181:Complement C4; D011415:Complement Factor B