[PUVA treatment of organ transplants--experimental and clinical results].
The aim of the present study was to evaluate the influence of a pretreatment of the heart and kidney donor with the photosensitizer 8-methoxypsoralen plus ex vivo longwave ultraviolet irradiation of the graft (PUVA) on survival time and immunogenicity of rat heart and kidney allografts. PUVA pretreatment significantly prolonged the survival of these transplants in allogenic recipients. Furthermore, a synergistic effect with conventional immunosuppression (azathioprine, cyclosporine) was demonstrated. Immunohistological studies using monoclonal antibodies showed a significant reduction of MHC class II antigen expression in heart cryostat sections after PUVA treatment. In clinical kidney transplantation the number of rejection episodes was significantly lower in the first 3 months in the PUVA-treated patient group.
Oesterwitz
H
H
Abteilung für experimentelle Organtransplantation, Bereiches Medizin (Charité), Humboldt-Universität, Berlin.
Kaden
J
J
Gruner
S
S
Schneider
W
W
Eichler
C
C
Schirrow
R
R
May
G
G
Scholz
D
D
Mebel
M
M
D000328:Adult; D000818:Animals; D006084:Graft Rejection / Q000187:drug effects*; D016027:Heart Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D051381:Rats; D011919:Rats, Inbred Strains; D012307:Risk Factors
PUVA-Behandlung von Organtransplantaten--experimentelle und klinische Ergebnisse.