A pilot study of three potential vaccines for leprosy in Bombay.
Three vaccines, BCG Glaxo alone (vaccine A), BCG Glaxo plus 10(7) killed Mycobacterium vaccae (vaccine B), and BCG Glaxo plus 10(7) killed M. leprae (vaccine C), were given to groups of selected children. The effects of these vaccines on subsequent quadruple skin testing 1-3 years after vaccination were compared. All three vaccines equally and significantly (p less than 0.00001) increased positivity to tuberculin, but only vaccine B was found to significantly enhance development of skin-test positivity to leprosin A (p less than 0.002). The data support the evidence previously obtained in rural Iran that the combination of BCG with killed M. vaccae is likely to be a better vaccine for leprosy than is BCG alone.
Ganapati
R
R
Bombay Leprosy Project, Bombay, Maharashtra, India.
Revankar
C R
CR
Lockwood
D N
DN
Wilson
R C
RC
Price
J E
JE
Ashton
P
P
Ashton
L A
LA
Holmes
R M
RM
Bennett
C
C
Stanford
J L
JL
D000293:Adolescent; D001500:BCG Vaccine; D001428:Bacterial Vaccines; D002675:Child, Preschool; D006801:Humans; D007194:India; D007918:Leprosy / Q000517:prevention & control*; D009166:Mycobacterium leprae / Q000276:immunology*; D010865:Pilot Projects; D012882:Skin Tests; D014611:Vaccination; D015164:Vaccines, Inactivated
D001500:BCG Vaccine; D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated