Aberrant T cell-mediated immunity in untreated schizophrenic patients: deficient interleukin-2 production.
The authors examined the immune status at the cellular and humoral levels of 16 untreated schizophrenic patients. No abnormality in the distribution of T cell subsets (CD4+, CD8+) was detected. The proliferative response to the T cell mitogen phytohemagglutinin was normal. No increase in the number of T cells showing activation markers, such as human leukocyte antigens and interleukin-2 receptors, was noted. Conversely, function studies revealed a clear deficiency in interleukin-2 production by purified T cells. This lower production was probably intrinsic to the patients' T cells, since interleukin-2 production showed normal sensitivity to prostaglandin E2-mediated down-regulation by autologous monocytes.
Villemain
F
F
INSERM U25, Hôpital Necker, Paris, France.
Chatenoud
L
L
Galinowski
A
A
Homo-Delarche
F
F
Ginestet
D
D
Loo
H
H
Zarifian
E
E
Bach
J F
JF
D000293:Adolescent; D000328:Adult; D000943:Antigens, Differentiation / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D002455:Cell Division; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007376:Interleukin-2 / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D016169:Lymphocyte Function-Associated Antigen-1; D008222:Lymphokines / Q000096:biosynthesis; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D008934:Mitogens; D010641:Phenotype; D011458:Prostaglandins E / Q000494:pharmacology; D015375:Receptors, Interleukin-2 / Q000187:drug effects; D012559:Schizophrenia / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D000943:Antigens, Differentiation; D001323:Autoantibodies; D007376:Interleukin-2; D016169:Lymphocyte Function-Associated Antigen-1; D008222:Lymphokines; D008562:Membrane Glycoproteins; D008934:Mitogens; D011458:Prostaglandins E; D015375:Receptors, Interleukin-2