Monitoring of heart allograft rejection by simultaneous measurement of serum beta 2-microglobulin and urinary neopterin.
In patients with heart transplant, the combined determination of serum beta 2-microglobulin and urinary neopterin, as rejection marker, prevented the interference by renal function and cyclosporin therapy. Unfortunately, the simultaneous measurement of these two parameters cannot distinguish between a rejection episode and the early stage of viral infection.
Schmitt
F
F
Laboratoire de Biochimie, Hôpital Broussais, Paris, France.
Myara
I
I
Benoit
M O
MO
Guillemain
R
R
Amrein
C
C
Dreyfus
G
G
Paris
M
M
Moatti
N
N
D001708:Biopterins / Q000031:analogs & derivatives* / Q000652:urine; D003404:Creatinine / Q000097:blood; D006084:Graft Rejection; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D001613:beta 2-Microglobulin / Q000032:analysis*
D001613:beta 2-Microglobulin; D001708:Biopterins; D019798:Neopterin; D003404:Creatinine