Development of the convenient and direct numerical analytical method of the pharmacokinetics of phenytoin by an ordinary and/or the Bayesian weighted least-squares method using the program MULTI2(BAYES).
A Simple and convenient numerical integration method was developed for the purpose of analyzing the pharmacokinetics of phenytoin not only at steady state but also at non-steady state. The algorithm was linked on a nonlinear least-squares method program MULTI2(BAYES). The computing time was significantly decreased compared to Runge-Kutta-Gill Method at analysis by the Simplex algorithm and calculating precision was higher, especially at a large integration interval. This method was found to be sufficiently applicable to the analyses of the serum concentrations of phenytoin at non-steady state as well as at steady state and the dosage adjustment by simulation. The flexibility of analyzed parameters on a microcomputer can be overcome by analyzing at the integration subinterval smaller than 0.25 h with the appropriate initial values of parameters, although very time consuming, or by using the Bayesian method with appropriate population parameters.
Fujita
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Department of Pharmacy, Yamaguchi University Hospital, Ube, Japan.
Koshiro
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D001499:Bayes Theorem; D006801:Humans; D016018:Least-Squares Analysis; D008432:Mathematical Computing; D009716:Numerical Analysis, Computer-Assisted; D010672:Phenytoin / Q000493:pharmacokinetics*; D012984:Software
D010672:Phenytoin