The antihypertensive properties of a synthetic prostanoid: RS-93427.
The antihypertensive activity of RS-93427, a synthetic prostanoid, was evaluated in conscious restrained spontaneously hypertensive rats. RS-93427 possesses potent antihypertensive activity when administered orally, intraduodenally, intravenously, or subcutaneously but not topically. The blood pressure reducing activity of RS-93427 in normotensive rats was comparable to that in hypertensive animals. No signs of tolerance to the antihypertensive effects were observed following fourteen days of oral administration of RS-93427. The synthetic prostanoid minimally enhanced the orthostatic hypotensive responsiveness to vertical, head up, repositioning of the restrained rats. The relative usefulness of the platelet antiaggregatory and antihypertensive properties of RS-93427 will have to be determined by clinical studies.
Wallach
M B
MB
Department of Neuropharmacology, Syntex Research, Palo Alto, CA 94304.
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects*; D001952:Bridged-Ring Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004386:Duodenum; D011464:Epoprostenol / Q000008:administration & dosage / Q000494:pharmacology; D006973:Hypertension / Q000188:drug therapy; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D011465:Prostaglandins, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR
D000959:Antihypertensive Agents; D001952:Bridged-Ring Compounds; D011465:Prostaglandins, Synthetic; C050064:RS 93427-007; D011464:Epoprostenol