title: [Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-- a prospective study].
abstract: Using a quantitative standardized procedure, the swelling of the ankle produced by supination trauma was measured. In the 66 patients with fresh rupture of the lateral ligament treated surgically at our Department between December 1986 and April 1987, a prospective study of the effect of serrapeptase (Aniflazym) on post-operative swelling and pain was carried out in 3 randomized groups of patients. In the group receiving the test substance, the swelling had decreased by 50% on the third post-operative day, while in the other two control groups (elevation of the leg, bed rest, with and without the application of ice) no reduction in swelling had occurred at that time. The difference is statistically significant (p = 0.013). Decreasing pain correlated for the most part with the reduction in swelling. Thus, the patients receiving the test substance more rapidly became pain-free than did the control groups. On the basis of these results, serrapeptase would appear to be an effective preparation for the post-operative reduction of swelling, in comparison with the classical conservative measures, for example, the application of ice.
authors.forename: P M
authors.initials: PM
authors.lastname: Esch
authors.forename: H
authors.initials: H
authors.lastname: Gerngross
authors.forename: A
authors.initials: A
authors.lastname: Fabian
mesh_terms: D000328:Adult; D016512:Ankle Injuries; D001265:Athletic Injuries / Q000601:surgery*; D004487:Edema / Q000188:drug therapy*; D006801:Humans; D008023:Ligaments, Articular / Q000293:injuries*; D008297:Male; D010447:Peptide Hydrolases / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000188:drug therapy*
chemical_list: D010447:Peptide Hydrolases; C022640:serratiopeptidase
vernacular_title: Postoperative Schwellungsreduktion. Objektive Schwellungsmessung am oberen Sprunggelenk unter Serrapeptase--eine prospektive Studie.