Immune thrombocytopenia more than a year after allogeneic marrow transplantation due to antibodies against donor platelets with anti-PlA1 specificity: evidence for a host-derived immune reaction.
We report on a male patient transplanted from his HLA-matched sister for Ph1-chromosome positive chronic myelogenous leukaemia who developed immune thrombocytopenia more than 1 year after transplantation. The platelet antibody reacted with the platelet specific antigen PlA1 on donor platelets, and also on recipient platelets after engraftment. A presumed host-versus-donor induced thrombocytopenia was supported by Southern blot analysis using a Y-chromosome specific probe demonstrating residual host-origin cells in the patient's excised spleen.
Panzer
S
S
First Medical Clinic, University of Vienna, Austria.
Kiefel
V
V
Bartram
C R
CR
Haas
O A
OA
Hinterberger
W
W
Mueller-Eckhardt
C
C
Lechner
K
K
D000328:Adult; D016824:Antigens, Human Platelet; D001792:Blood Platelets / Q000276:immunology; D016026:Bone Marrow Transplantation; D006789:Host vs Graft Reaction; D006801:Humans; D007154:Immune System Diseases / Q000209:etiology*; D039661:Integrin beta3; D007518:Isoantibodies / Q000276:immunology; D007519:Isoantigens / Q000276:immunology; D008297:Male; D013921:Thrombocytopenia / Q000209:etiology*; D013997:Time Factors
D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007518:Isoantibodies; D007519:Isoantigens