Enhanced gentamicin killing of Escherichia coli by tet gene expression.
Time-kill studies were performed to determine the effect of tetracycline resistance (tet) gene expression on gentamicin killing of Escherichia coli. Expression of tet increased gentamicin killing in laboratory strains and clinical isolates. A role for tetracycline in inducing tet expression and increasing the bactericidal activity of aminoglycosides is suggested.
Merlin
T L
TL
Laboratory Service, Albuquerque Veterans Administration Medical Center, New Mexico 87108.
Corvo
D L
DL
Gill
J H
JH
Griffith
J K
JK
D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D005839:Gentamicins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013753:Tetracycline Resistance
D005839:Gentamicins