The purine path to chemotherapy.
Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia (6-mercaptopurine and thioguanine), gout and hyperuricemia (allopurinol), and herpesvirus infections (acyclovir), and for the prevention of organ transplant rejection (azathioprine).
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Wellcome Research Laboratories, Burroughs Wellcome Company, Research Triangle Park, NC 27709.
D000818:Animals; D004358:Drug Therapy; D006801:Humans; D011687:Purines
D011687:Purines