[Direct immunofluorescence study of active psoriasis lesions].
Active psoriatic lesions have been investigated by direct immunofluorescence technique with polyclonal antisera to immunoglobulins and C3. We observed a cytoplasmic fluorescence of suprapapillary, suprabasally keratinocytes with tight topographical relationship to the parakeratotic horny layer. The intracellular deposits were IgA (in 60% of cases), IgG (53%), IgM (47%), C3 (30%). IgE und IgD have not been detected. The relationship of cytoplasmic protein deposition in vivo to parakeratosis is discussed briefly.
Wollina
U
U
Schaarschmidt
H
H
Koch
H J
HJ
Knopf
B
B
D001323:Autoantibodies / Q000032:analysis*; D001666:Binding Sites, Antibody; D001706:Biopsy; D003176:Complement C3 / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D011565:Psoriasis / Q000473:pathology*; D012867:Skin / Q000276:immunology / Q000473:pathology
D001323:Autoantibodies; D003176:Complement C3; D007136:Immunoglobulins
Direkte Immunfluoreszenzuntersuchung aktiver Psoriasisherde.