Cyclosporine nephrotoxicity.
Cyclosporine is a potent and useful immunosuppressive agent used primarily in conjunction with solid organ transplantation. The most serious adverse reaction that limits its use is nephrotoxicity due to effects on the renal vasculature, glomeruli, and tubular function. These effects result in a variety of clinical syndromes. This review outlines the clinical syndromes and discusses way to minimize nephrotoxicity in patients receiving cyclosporine.
Steinmuller
D R
DR
D003524:Cyclosporins / Q000009:adverse effects*; D004357:Drug Synergism; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D007684:Kidney Tubules / Q000187:drug effects; D012079:Renal Circulation / Q000187:drug effects
D003524:Cyclosporins