[Effects of experimental coronary artery stenosis on platelet function].
In mild stenosis, coronary blood flow (CBF) was unchanged, thromboxane (TX) B2/6-ketoprostaglandin (PG) F1a ratio rose with no change in PAgT. In critical stenosis, CBF was slightly decreased, PAgT, TXB2 and TXB2/PGF1a ratio rose with cyclical reduction in CBF. In severe stenosis, CBF was markedly decreased; PAgT, TXB2 and TXB2/6-keto-PGF1a ratio rose and 6-keto-PGF1a decreased with cyclical blood flow reduction. Histopathologic examination confirmed the presence of damaged endothelial cell with coronary thrombosis and platelet/fibrin microemboli in critical and severe stenosis. It is concluded that coronary artery stenosis leads to a damage of endothelial cell, which causes an abnormality in platelet function and coronary thrombosis.
Chen
S L
SL
Zang
Y M
YM
Zhu
M Z
MZ
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D003327:Coronary Disease / Q000097:blood* / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology; D004285:Dogs; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D008297:Male; D010974:Platelet Aggregation; D013929:Thromboxane B2 / Q000097:blood
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha