Age-dependent increase of Campylobacter pylori antibodies in blood donors.
Antibodies against Campylobacter pylori were determined in 500 blood donors aged 18 to 65 years. Acid extract from a C. pylori strain was used as antigen in enzyme immunoassay. The proportion of donors with high antibody titers increased with age. For IgG antibodies it was 10% in the age group from 18 to 25 years but 60% in the group from 56 to 65 years; the increase for IgA and IgM antibodies was from 5 to 42% and from 7 to 21%, respectively. The geometric mean titers of those with high values showed no clear changes with age, which would imply chronic antigenic stimulus.
Kosunen
T U
TU
Dept. of Bacteriology and Immunology, University of Helsinki, Finland.
Höök
J
J
Rautelin
H I
HI
Myllylä
G
G
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis*; D001782:Blood Donors; D002167:Campylobacter / Q000276:immunology*; D005260:Female; D005387:Finland; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged
D000907:Antibodies, Bacterial