title: MLTIDOSE: a multiple-dose simulation program for linear systems characterized by exponential functions.
abstract: MLTIDOSE is a multiple-dose simulation program for use on IBM PC (and compatible) computers. It assumes dose-independent disposition and absorption (i.e., a linear system) and simulates blood concentration-time profiles (over a range of times or at specific times) upon administration of any combination of intravascular (i.v.) (bolus and/or intermittent constant rate infusions) and extravascular (e.v.) doses of fixed or variable size, administered at fixed or variable intervals. Input requirements include pharmacokinetic parameters obtained following single-dose administration (entered from the keyboard or from a data file). Options for printing data to files (e.g., ASCII and DIF) for further use are also provided.
authors.affiliation: Merrell Dow Research Institute, Department of Drug Metabolism, Cincinnati, Ohio 45215.
authors.forename: G A
authors.initials: GA
authors.lastname: Thompson
authors.forename: R C
authors.initials: RC
authors.lastname: Shumaker
mesh_terms: D003198:Computer Simulation; D004334:Drug Administration Schedule; D008433:Mathematics; D010599:Pharmacokinetics; D012984:Software