The effect of Corynebacterium parvum in influenza infected mice.
This paper is the continuation of earlier studies on the effect of the killed suspension of Corynebacterium parvum in influenza virus infected mice. Our investigation showed the normalized effect of these drugs on disturbed function of cell mediated immunity during experimental influenza infection especially in phagocytic and bactericidal activity of granulocytes. The present experiments concern the explanation of these infection mechanisms. Intraperitoneal injection of Corynebacterium parvum stimulated spleen index. Foot pad test is higher than in comparatively treated BCG group. The pathomorphological analysis of the spleen, thymus and peritoneal lymph nodes points out to the multiplication of multiple lymph nodes sinus cells. Generally, C. parvum possessed protective effect in experimental influenza infection. We tested the following parameters: phagocytic and bactericidal activity of granulocytes, liberation of leukocytes migration inhibition factor (LIF).
Białek
J
J
Department of Medical Microbiology, Military Medical Academy, Lódź.
Denys
A
A
Kowalska
M
M
Ciebiada
I
I
Szydłowska
T
T
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D001428:Bacterial Vaccines; D003352:Corynebacterium; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy / Q000276:immunology*
D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; C039725:Corynebacterium parvum vaccine