Inotropic effects of endothelin in ferret ventricular myocardium.
The characteristics of the inotropic response to endothelin were studied in isolated ferret papillary muscle preparations. Endothelin (0.1-10 nM) induced concentration-dependent positive inotropic effects. At 10 nM, isometric tension increased by 17%, maximum rate of tension development by 18%, maximum velocity of unloaded shortening by 23% and peak isotonic shortening by 11%. Time to peak isometric tension and half isometric relaxation time were unaltered by endothelin. This pattern of change is similar to that of elevating extracellular calcium concentration.
Shah
A M
AM
Department of Cardiology, University of Wales College of Medicine, Heath Park, Cardiff, U.K.
Lewis
M J
MJ
Henderson
A H
AH
D000818:Animals; D002335:Carnivora / Q000502:physiology*; D016232:Endothelins; D005289:Ferrets / Q000502:physiology*; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology*
D016232:Endothelins; D010455:Peptides