[Effects of prospidin on the development of pulmonary metastases of Lewis tumors in rats in regard to changes in the level of extracellular calcium].
The effect of prospidin on Lewis lung carcinoma spreading under hyper- and hypocalcemia was studied. At early stages, increased extracellular calcium level was associated with inhibition of tumor dissemination to the lungs; however, later, colony growth was stimulated. Extracellular calcium level was shown to modulate the antitumor and antimetastatic effect of prospidin.
Kinzirskiĭ
A S
AS
Chernov
V A
VA
Shapovalova
L M
LM
Galochkina
Z I
ZI
Mikhaĭlevskaia
L L
LL
Surovenkova
N N
NN
D000230:Adenocarcinoma / Q000097:blood / Q000556:secondary*; D000818:Animals; D002118:Calcium / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood / Q000556:secondary*; D051379:Mice; D008810:Mice, Inbred C57BL; D010879:Piperazines / Q000494:pharmacology*; D011447:Prospidium / Q000494:pharmacology*
D010879:Piperazines; D011447:Prospidium; D002118:Calcium
Vliianie prospidina na razvitie legochnykh metastazov opukholi L'iuis na fone izmeneniia urovnia vnekletochnogo kal'tsiia.