[A patient with an immunodeficiency and consecutively 3 primary malignancies].
Patients with a primary immunodeficiency syndrome have an increased risk of the development of a malignancy. Lymphoreticular malignancies are the most common malignancies in these patients. Patients with ataxia telangiectasia (AT) also appear to be at a high risk for the development of non-lymphoid tumors, in particular carcinomas of the gastrointestinal tract and central nervous system tumors. We describe a child with an immunodeficiency and slight neurologic manifestations. During childhood she developed consecutive three primary malignancies.
Groot-Loonen
J J
JJ
Emma Kinderziekenhuis Amsterdam.
Slater
R
R
Taminiau
J
J
Voûte
P A
PA
D000230:Adenocarcinoma / Q000150:complications*; D001254:Astrocytoma / Q000150:complications*; D001932:Brain Neoplasms / Q000150:complications*; D002648:Child; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D009378:Neoplasms, Multiple Primary; D012811:Sigmoid Neoplasms / Q000150:complications*; D013601:T-Lymphocytes
Een patiënt met een immunodeficiëntie en achtereenvolgens drie primaire maligniteiten.