Chemical manipulations of tissue oxygenation for therapeutic benefit.
Many new approaches are currently being explored to improve cancer treatment through hypoxic cell radiosensitization. Oxygen carriers, calcium antagonists, some drugs which shift the oxygen hemoglobin curve to the right improve the oxygen availability in the tumors. An alternative way to improve radiotherapy or chemotherapy is to increase tumor hypoxia either by shifting the hemoglobin oxygen dissociation curve to the left or by using vasodilators. This paper summarizes main results obtained in that field. The relevance of data obtained from animal experiments to clinical practice will be discussed.
Guichard
M
M
Laboratoire de Radiobiologie Cellulaire (Unité Inserm 247), Institut Gustave-Roussy, Villejuif, France.
D000818:Animals; D004338:Drug Combinations / Q000627:therapeutic use; D005466:Fluorocarbons / Q000627:therapeutic use; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D009369:Neoplasms / Q000503:physiopathology / Q000628:therapy*; D009374:Neoplasms, Experimental / Q000503:physiopathology / Q000628:therapy*; D010100:Oxygen / Q000502:physiology*; D010108:Oxyhemoglobins / Q000378:metabolism; D014665:Vasodilator Agents / Q000627:therapeutic use
D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D010108:Oxyhemoglobins; D014665:Vasodilator Agents; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D010100:Oxygen