Oxidative stress and muscular dystrophy.
Oxidative stress may be the fundamental basis of many of the structural, functional and biochemical changes characteristic of the inherited muscular dystrophies in animals and humans. The presence of by-products of oxidative damage, and the compensatory increases in cellular antioxidants, both indicate oxidative stress may be occurring in dystrophic muscle. Changes in the proportions and metabolism of cellular lipids, abnormal functions of cellular membranes, altered activity of membrane-bound enzymes such as the SR Ca2+-ATPase, disturbances in cellular protein turnover and energy production and a variety of other changes all indicate that these inherited muscular dystrophies appear more like the results of oxidative stress to muscle than any other type of underlying muscle disturbance. Particular details of these altered characteristics of dystrophic muscle, in combination with current knowledge on the processes of oxidative damage to cells, may provide some insight into the underlying biochemical defect responsible for the disease, as well as direct research towards the ultimate goal of an effective treatment.
Murphy
M E
ME
Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin 78712-1074.
Kehrer
J P
JP
D000818:Animals; D006801:Humans; D015227:Lipid Peroxidation; D008962:Models, Theoretical; D009132:Muscles / Q000378:metabolism*; D009136:Muscular Dystrophies / Q000209:etiology / Q000378:metabolism*; D009137:Muscular Dystrophy, Animal / Q000209:etiology / Q000378:metabolism*; D010084:Oxidation-Reduction