Expression of lymphocyte homing receptor as a mechanism of dissemination in non-Hodgkin's lymphoma.
To investigate whether the lymphocyte homing receptor (LHR), an adhesion molecule believed to play an important role in the control of normal lymphocyte circulation, influences the spread of non-Hodgkin's lymphoma (NHL), expression of LHR was examined in 107 NHL of various histologic and immunophenotypic subclasses. This analysis revealed that whereas NHL with a putative derivation from recirculating mature T and B lymphocytes almost invariably express high levels of LHR, those akin to sessile mature or immature lymphocytes tend to express lower levels of LHR. Furthermore, in a survey among diffuse large-cell lymphomas of the B-lineage, the tumors of 11 of 13 patients with stage III/IV disease expressed moderate to high levels of LHR, whereas only two of 17 patients with stage I/II disease had tumors that did so. These findings suggest that LHR is involved in the dissemination of NHL.
Pals
S T
ST
Department of Pathology, Free University, Amsterdam, The Netherlands.
Horst
E
E
Ossekoppele
G J
GJ
Figdor
C G
CG
Scheper
R J
RJ
Meijer
C J
CJ
D000911:Antibodies, Monoclonal; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000032:analysis / Q000276:immunology*; D011971:Receptors, Immunologic / Q000032:analysis / Q000276:immunology*; D016201:Receptors, Lymphocyte Homing
D000911:Antibodies, Monoclonal; D011971:Receptors, Immunologic; D016201:Receptors, Lymphocyte Homing