title: The severity of RDS during the first two neonatal days in relationship to fluid intake.
abstract: There are no generally accepted guidelines regarding the degree of hydration of small preterm infants with RDS. In the present prospective study, liquid intake (intravenous fluids, drugs, and enteral nutrition) during the first 48 h was correlated with the degree of respiratory failure at the age of two days in 120 consecutive, mechanically ventilated, small preterm infants with RDS (GA less than 30 w, BW less than 1,750 g). There was a positive linear relationship between the amount of liquids given and the degree of respiratory failure. Multiple regression analysis taking into consideration various perinatal factors revealed that the liquid intake explained the degree of respiratory failure (p less than 0.0001). The regression analysis revealed a similar dependence of respiratory failure on the liquid intake in the following groups of infants: GA less than 27 w (p = 0.023); GA 27-30 w (p = 0.005); SGA (p = 0.104); Non-SGA (p = 0.001); severe preeclampsia (p = 0.018); surfactant substitution (p = 0.002); liquid intake 127-240 ml/48 h (p less than 0.006); liquid intake 240-430 ml/48 h (p less than 0.047). The present results demonstrate the need to re-evaluate the optimal needs of hydration among infants with RDS during the very early neonatal period.
authors.affiliation: Deparment of Paediatrics, University of Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Hallman
mesh_terms: D015984:Causality; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects*; D006801:Humans; D007225:Infant Food / Q000009:adverse effects*; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D012307:Risk Factors