title: Involvement of tumour necrosis factor and other cytokines in immune-mediated vascular pathology.
abstract: Vascular endothelial cells are actively involved in coagulation and inflammation processes and appear to represent an important element in cell-mediated immune responses. In this paper, the possible role of endothelial cells as a target for immunopathological reactions was analyzed. Experimental neurovascular lesions were studied in a model of cerebral malaria, with particular attention to the role of cytokine interactions in vivo.
authors.affiliation: Department of Pathology, University of Geneva, Switzerland.
authors.forename: G E
authors.initials: GE
authors.lastname: Grau
authors.forename: P F
authors.initials: PF
authors.lastname: Piguet
authors.forename: P
authors.initials: P
authors.lastname: Vassalli
authors.forename: P H
authors.initials: PH
authors.lastname: Lambert
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000502:physiology*; D001927:Brain Diseases / Q000473:pathology / Q000503:physiopathology; D016207:Cytokines; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology*; D008264:Macrophages / Q000502:physiology; D008288:Malaria / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D010962:Plasmodium berghei; D013601:T-Lymphocytes / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*; D014657:Vasculitis / Q000473:pathology / Q000503:physiopathology*
chemical_list: D001685:Biological Factors; D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha