Influence of pH on intestinal fluoride transport in vitro.
The effect of pH on intestinal fluoride (F) absorption was investigated in vitro using isolated segments of dog jejunum in a 2-chamber system. The pH of the mucosal buffer was varied in the range 6.5-8.2, and F concentration in the range 0.11-1.1 mM (2.1-21 ppm F). The serosal buffer was held constant at pH 7.5. No effect of pH within this physiological range was observed on F transport across the intestinal segment. Much lower pH values on the mucosal side inhibited F transport, but this appeared to be secondary to toxic effects on the epithelium, including an inhibition of water transport. Within the range tested, no evidence was found supporting the concept that F transport across intestinal epithelium occurs as the undissociated hydrogen fluoride (HF).
Messer
H H
HH
Nopakum
J
J
Rudney
J D
JD
D000704:Analysis of Variance; D000818:Animals; D001692:Biological Transport; D002021:Buffers; D004285:Dogs; D005459:Fluorides / Q000493:pharmacokinetics*; D006858:Hydrofluoric Acid / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption; D008297:Male; D012044:Regression Analysis
D002021:Buffers; D005459:Fluorides; D006858:Hydrofluoric Acid