Significant changes in nonspecific bronchial responsiveness after isolated immediate bronchospecific reactions caused by isocyanates but not after a late reaction caused by plicatic acid.
Although late bronchospastic reactions after exposure to antigenic and sensitizing agents usually significantly alter bronchial responsiveness to histamine or methacholine, presumably by causing bronchial inflammation, isolated immediate bronchospastic reactions do not induce such changes. We studied three subjects who demonstrated different patterns of reaction. The first individual was diagnosed as having occupational asthma to red cedar. This was confirmed by specific inhalation challenges that resulted in late bronchospastic reaction. No significant changes in the provocative concentration of histamine causing a 20% fall in FEV1 (PC20) were found 1 day after this reaction. Two weeks later, serial assessments (five and six, respectively) of PC20 histamine were recorded on control days and up to 48 hours after exposure to plicatic acid, which caused a late bronchospastic reaction with a maximum fall of 37% in FEV1. No significant changes in PC20 were found; the maximum variations on control days were 0.36 to 0.74 mg/ml, and on active days, from 0.37 to 0.59 mg/ml. By contrast, two other subjects, who demonstrated isolated immediate reactions after exposure to diphenylmethane diisocyanate, had significant changes in PC20 histamine and methacholine, in one subject from 3.1 mg/ml to 0.6 mg/ml 8 hours after exposure, and in the other subject, from 61.0 to 7.4 mg/ml 7 hours after exposure, with recovery during the next few days. These examples demonstrate that the pattern of nonspecific bronchial responsiveness after immediate and late bronchospastic reactions can be different from what has previously been described. Immediate bronchospastic reactions may lead to bronchial hyperresponsiveness, whereas late asthmatic reactions do not always induce changes in bronchial responsiveness.(ABSTRACT TRUNCATED AT 250 WORDS)
Malo
J L
JL
Department of Chest Medicine, Hôpital du Sacré-Coeur, Montreal, Quebec, Canada.
L'Archevêque
J
J
Cartier
A
A
D000328:Adult; D001249:Asthma / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D001986:Bronchial Spasm / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology; D003485:Cyanates / Q000009:adverse effects*; D005541:Forced Expiratory Volume; D006632:Histamine; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology; D006969:Hypersensitivity, Immediate / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology; D017953:Isocyanates; D017705:Lignans; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds; D008875:Middle Aged; D009284:Naphthols / Q000009:adverse effects*; D009784:Occupational Diseases / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology; D001559:Benzhydryl Compounds
D003485:Cyanates; D006632:Histamine; D017953:Isocyanates; D017705:Lignans; D016210:Methacholine Chloride; D008688:Methacholine Compounds; D009284:Naphthols; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds; C008938:plicatic acid