Computer-assisted predictive mathematical relationship among plasma acetaminophen concentration and time and hepatotoxicity in man.
A microcomputer program in BASIC for predicting hepatoxicity in man resulting from a single overdosage ingestion of acetaminophen was designed. A formula used in this program is derived from the data reported by Prescott and his coworkers (Lancet i (1971) 519-522). Analysis of the actually reported and the computer-assisted predicted data has shown that the computer-assisted predictive formula may be clinically helpful in determining if the plasma acetaminophen level is in the toxic or nontoxic range.
Chung
S J
SJ
Department of Pathology, Morristown-Hamblen Hospital, TN 37814.
D000082:Acetaminophen / Q000097:blood* / Q000493:pharmacokinetics / Q000506:poisoning; D000293:Adolescent; D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D008107:Liver Diseases / Q000097:blood*; D008657:Metabolic Clearance Rate; D008838:Microcomputers; D008875:Middle Aged; D008962:Models, Theoretical; D011237:Predictive Value of Tests
D000082:Acetaminophen