Duration of paternal alcohol consumption does not influence offspring growth and development.
Three groups of male mice consumed liquid alcohol diets containing 25%, 10% or 0% ethanol derived calories (EDC) ad lib. Two additional groups were pair-fed to two of these groups, one to the 25% EDC group and one to the 10% EDC group. This pair feeding procedure was performed on an individual basis creating a dyad in which each individual in the pair received the same amount of calories but the source of the calories for alcohol varied. Males were bred to non-treated females after 1-2, 3-4 or 6-7 weeks of consumption. Male fertility was not affected by alcohol consumption. Offspring sired by alcohol consuming males did not differ from either ad lib or pair-fed controls in litter size, birth weight or weight at weaning regardless of duration of paternal alcohol consumption. These results indicate that neither duration of paternal alcohol consumption nor alcohol-induced undernutrition affects these gross morphological parameters in offspring.
Abel
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Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan.
D000428:Alcohol Drinking / Q000502:physiology*; D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D004032:Diet; D002149:Energy Intake / Q000502:physiology; D005220:Fathers; D005260:Female; D005298:Fertility / Q000187:drug effects; D006128:Growth; D008098:Litter Size / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D011247:Pregnancy; D012744:Sex Ratio; D013091:Spermatogenesis / Q000187:drug effects / Q000502:physiology; D013997:Time Factors