title: Tamm-Horsfall protein accumulation in glomeruli during acetazolamide-induced acute renal failure.
abstract: A patient with ocular hypertension was treated with acetazolamide. Acute renal failure developed rapidly and renal biopsy showed mild tubular lesions and crystal formation in a tubular lumen. By immunofluorescence studies with a monoclonal antibody, Tamm-Horsfall protein, normally absent from the proximal segments of the nephron, was detected in most glomeruli. This strongly suggests that tubular obstruction plays a major part in some cases of acetazolamide-induced acute renal failure.
authors.affiliation: Service de Néphrologie, Hôpital Tenon, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Rossert
authors.forename: E
authors.initials: E
authors.lastname: Rondeau
authors.forename: G
authors.initials: G
authors.lastname: Jondeau
authors.forename: P
authors.initials: P
authors.lastname: Ronco
authors.forename: B
authors.initials: B
authors.lastname: Mougenot
authors.forename: A
authors.initials: A
authors.lastname: Kanfer
authors.forename: J D
authors.initials: JD
authors.lastname: Sraer
mesh_terms: D000086:Acetazolamide / Q000009:adverse effects* / Q000627:therapeutic use; D058186:Acute Kidney Injury / Q000139:chemically induced*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009088:Mucoproteins / Q000378:metabolism*; D009798:Ocular Hypertension / Q000188:drug therapy; D058949:Uromodulin
chemical_list: D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin; D000086:Acetazolamide