Does central nervous system toxicity occur in transplant patients with hypocholesterolemia receiving cyclosporine?
A syndrome of severe central nervous system toxicity (confusion, cortical blindness, quadriplegia, seizures, and coma) associated with cyclosporine therapy and a low serum cholesterol level in patients with liver transplants has been described. We present a case history of a patient who demonstrated several similar features after heart-lung transplantation. Possible cyclosporine neurotoxicity should be considered in any patients with hypocholesterolemia receiving this drug.
Cooper
D K
DK
Oklahoma Transplantation Institute, Baptist Medical Center, Oklahoma City 73112.
Novitzky
D
D
Davis
L
L
Huff
J E
JE
Parker
D
D
Schlesinger
R
R
Sholer
C
C
Zuhdi
N
N
D000328:Adult; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D002784:Cholesterol / Q000097:blood*; D003524:Cyclosporins / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D016040:Lung Transplantation; D011183:Postoperative Complications / Q000209:etiology
D000961:Antilymphocyte Serum; D003524:Cyclosporins; D002784:Cholesterol; D001379:Azathioprine