title: Biologic rationale for hyperthermia.
abstract: This article discusses the basic biologic data relative to the use of hyperthermia as an adjuvant to ionizing radiation in the treatment of solid tumors. The cytotoxic effects of hyperthermia are presented, as are parameters that modify cellular sensitivity. In vivo physiologic changes associated with hyperthermia are also considered. Finally, the in vitro and in vivo interactions between hyperthermia and radiation are discussed, particularly as they relate to improved tumor response.
authors.affiliation: Oakland University, Rochester.
authors.forename: F W
authors.initials: FW
authors.lastname: Hetzel
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D003131:Combined Modality Therapy; D006358:Hot Temperature; D006979:Hyperthermia, Induced; D066298:In Vitro Techniques; D051379:Mice; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000532:radiotherapy / Q000628:therapy*