[The subchronic toxicity of 5-vinyloxazolidine-2-thione in rats].
Groups of male and female rats received 5-vinyloxazolidine-2-thione (VOT) in their drinking water for 13 weeks at concentrations of 0, 10, 25, 50 or 100 mg/l and 0, 2.5 or 5 mg/l respectively. Compared with the controls, there were decreases in food intake and growth of females given VOT-doses of 10 mg/l and higher. Liquid intake was reduced in males and females of the highest dose group. Terminal haematological examination revealed an increase in white cell count at the 50 and 100 mg levels in females and a reduction in the red cell count at 100 mg/l in males. Organ weight changes were dose-related increases in the relative thyroid and liver weight and a decrease in the relative thymus weight. Structural and functional changes of the thyroid were observed in animals at levels of 10 mg/l and higher. Histological examinations of the kidneys showed tubulonephrosis in animals at and above a VOT-level of 5 mg/l. The no-observed-effect level (NOEL) established from these studies was 2.5 ml VOT/l drinking water (approximately equivalent to an daily intake of 0.4 mg/kg body weight).
Lewerenz
H J
HJ
Zentralinstitut für Ernährung in Postsdam-Rehbrücke, Akademie der Wissenschaften der DDR.
Bleyl
D W
DW
Plass
R
R
Przybilski
H
H
Schnaak
W
W
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D004906:Erythrocyte Count / Q000187:drug effects; D005260:Female; D007958:Leukocyte Count / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010080:Oxazoles / Q000633:toxicity*; D023303:Oxazolidinones; D010936:Plant Extracts / Q000633:toxicity*; D051381:Rats; D012727:Sex Characteristics; D013950:Thymus Gland / Q000187:drug effects; D013961:Thyroid Gland / Q000187:drug effects
D010080:Oxazoles; D023303:Oxazolidinones; D010936:Plant Extracts; C004333:goitrin
Untersuchung der subchronischen Toxizität von 5-Vinyloxazolidin-2-thion an Ratten.