[Lipid peroxidation in the etiology and pathogenesis of atherosclerosis].
Reviewing the data available in the literature and their own findings, the authors consider the role of lipid peroxidation in the etiology and pathogenesis of atherosclerosis. The paper provides a good evidence for intensified peroxidation of hepatic lipids and liver-secreted atherogenic lipoproteins in atherogenesis, which is followed by blood lipid peroxides accumulation in hypercholesterolemia and atherosclerosis. The excess of aortic lipid peroxides occurs concurrently with a sharp decrease in the activity of the enzymatic systems in utilizing lipid peroxides. Accumulation of lipid peroxides in the aorta may be a factor that contributes to higher migration and proliferation of smooth muscle cells forming a cellular basis for an atherosclerotic plaque. The products of cholesterol oxidation were also reported to exert an atherogenic action.
Lankin
V Z
VZ
Bikhert
A M
AM
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology*; D006801:Humans; D015227:Lipid Peroxidation
Perekisnoe okislenie lipidov v étiologii i patogeneze ateroskleroza.