Potent contractile activity of endothelin on the human isolated urinary bladder.
Endothelin (1 nM-0.3 microM) produced a concentration-related contraction of mucosa-free muscle strips excised from the dome of the human urinary bladder. The response to endothelin was unaffected by either atropine (1 microM) or nifedipine (1 microM) at concentrations that abolished the response to carbachol and KCl, respectively. These findings indicate that mechanisms other than activation of dihydropyridine- and voltage-sensitive calcium channels may be involved in the action of endothelin on smooth muscles.
Maggi
C A
CA
Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
Giuliani
S
S
Patacchini
R
R
Santicioli
P
P
Turini
D
D
Barbanti
G
G
Meli
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016232:Endothelins; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects
D016232:Endothelins; D010455:Peptides; D011189:Potassium Chloride; D007545:Isoproterenol