title: [Comparison of blood pressure profiles with flunitrazepam/fentanyl/nitrous oxide vs cervical epidural anesthesia in surgery of the carotid artery].
abstract: A study was carried out to compare the evolution of arterial blood pressure during carotid endarterectomy performed under either general anaesthesia (GA) or cervical epidural anaesthesia (CEA). 20 patients were randomly assigned to two equal groups. In the CEA group, 15 ml of 0.375% bupivacaine and 150 micrograms fentanyl were injected into the epidural space at C7-D1 level. In the GA group, patients were anaesthetized with 0.2 mg.kg-1 flunitrazepam and 5 micrograms.kg-1 fentanyl; intubation was carried out using 0.08 mg.kg-1 vecuronium, and the patients were ventilated with a mixture of nitrous oxide and oxygen (50% of each). Further injections, every 30 min, of 2 micrograms.kg-1 fentanyl were given to the patients in group GA. Blood pressure was monitored continuously, up to 4 h postoperatively, with a radial arterial catheter. Per- or postoperative hypertension was defined as a rise in systolic arterial blood pressure (Pasys) over 180 mmHg for greater than 3 min; this was treated with 20 mg nifedipine intranasally (group CEA) or 100 micrograms fentanyl with 0.5 mg flunitrazepam with or without nifedipine (group GA). Per- or postoperative hypotension was defined as a fall in Pasys below 100 mmHg and or a 30% fall in mean arterial blood pressure for greater than 3 min; this was treated, in both groups, with an intravenous bolus of 3 mg ephedrine. Patients in group CEA experienced more frequent episodes of peroperative hypertension (8/2; p less than 0.02) and postoperative hypotension (5/1) than group GA.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Département d'Anesthésie-Réanimation n. II, Hôpital Henri-Mondor, Créteil.
authors.forename: F
authors.initials: F
authors.lastname: Pluskwa
authors.forename: F
authors.initials: F
authors.lastname: Bonnet
authors.forename: K
authors.initials: K
authors.lastname: Abhay
authors.forename: C
authors.initials: C
authors.lastname: Touboul
authors.forename: B
authors.initials: B
authors.lastname: Rey
authors.forename: J
authors.initials: J
authors.lastname: Marcandoro
authors.forename: J B
authors.initials: JB
authors.lastname: Becquemin
mesh_terms: D000368:Aged; D000767:Anesthesia, Epidural; D000771:Anesthesia, Intravenous / Q000379:methods; D001794:Blood Pressure / Q000187:drug effects*; D002340:Carotid Artery Diseases / Q000601:surgery*; D002986:Clinical Trials as Topic; D004691:Endarterectomy; D005260:Female; D005283:Fentanyl; D005445:Flunitrazepam; D006801:Humans; D006973:Hypertension / Q000150:complications; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D011184:Postoperative Period
chemical_list: D005445:Flunitrazepam; D009609:Nitrous Oxide; D005283:Fentanyl
vernacular_title: Comparaison des profils tensionnels sous flunitrazépam/fentanyl/N2O vs anesthésie péridurale cervicale pour chirurgie carotidienne.