title: Multicenter comparative study of aztreonam and gentamicin in the treatment of renal and urinary tract infections.
abstract: A multicenter comparative study was carried out to evaluate the efficacy of aztreonam and gentamicin in 186 patients with symptomatic renal or urinary tract infections. Patients were divided randomly into two groups: 94 patients received aztreonam 1 g/day intramuscularly and 92 patients received gentamicin 80 mg i.m. twice daily. The clinical and microbiologic results found a single daily dose of aztreonam to be more effective than gentamicin b.i.d. Furthermore, no evidence of side effects was seen with aztreonam. Such results are generally thought to ensure better compliance in outpatients.
authors.affiliation: Institute of Nephrology, S. Camillo De Lellis University Hospital, Chieti, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Albertazzi
authors.forename: M
authors.initials: M
authors.lastname: Bonadio
authors.forename: M
authors.initials: M
authors.lastname: Fusaroli
authors.forename: T
authors.initials: T
authors.lastname: Lotti
authors.forename: L
authors.initials: L
authors.lastname: Miano
authors.forename: G
authors.initials: G
authors.lastname: Salvia
authors.forename: M
authors.initials: M
authors.lastname: Sasdelli
authors.forename: G
authors.initials: G
authors.lastname: Villa
authors.forename: P
authors.initials: P
authors.lastname: Zucchelli
authors.forename: L
authors.initials: L
authors.lastname: Ventriglia
mesh_terms: D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D001398:Aztreonam / Q000008:administration & dosage / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007273:Injections, Intramuscular; D007558:Italy; D007674:Kidney Diseases / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011897:Random Allocation; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D005839:Gentamicins; D001398:Aztreonam