Effect of various cytokines and growth factors on the interleukin-2-dependent in vitro differentiation of natural killer cells from bone marrow.
We have studied the possible role of various cytokines and growth factors on the in vitro interleukin-2 (IL-2)-dependent development of natural killer (NK) cells from bone marrow precursors. Our results indicate that tumor necrosis factor alpha and lymphotoxin augment the generation of NK cells. In contrast, interleukin-4, transforming growth factor beta and granulocyte-macrophage colony-stimulating factor significantly inhibit this phenomenon. Other factors tested, such as epidermal growth factor and fibroblast growth factor, did not detectably influence the IL-2-dependent development of NK cells.
Migliorati
G
G
Institute of Pharmacology, School of Medicine, University of Perugia, Italy.
Cannarile
L
L
Herberman
R B
RB
Riccardi
C
C
D000818:Animals; D001685:Biological Factors / Q000494:pharmacology*; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D016207:Cytokines; D005260:Female; D006133:Growth Substances / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D014407:Tumor Cells, Cultured
D001685:Biological Factors; D016207:Cytokines; D006133:Growth Substances; D007376:Interleukin-2