Expression of a multidrug resistance gene in blast crisis of chronic myelogenous leukemia.
Three of four patients with chronic myelogenous leukemia in blast crisis were found to express the multidrug resistance (MDR1) gene in their blast cells. Expression of the MDR1 gene may contribute to the poor response of these patients to chemotherapy.
Pirker
R
R
First Medical Clinic, University of Vienna Medical School, Austria.
Goldstein
L J
LJ
Ludwig
H
H
Linkesch
W
W
Lechner
C
C
Gottesman
M M
MM
Pastan
I
I
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001752:Blast Crisis / Q000235:genetics*; D001853:Bone Marrow / Q000473:pathology; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012334:RNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification
D012334:RNA, Neoplasm