Association of HLA-DR antigens with the development of cytotoxic antibodies in patients on dialysis.
Association between DR antigens and the occurrence of cytotoxic alloantibodies was studied in 251 patients on dialysis. Patients awaiting their first kidney graft were DR typed, and periodically investigated for the presence of alloantibodies. According to the observed peak panel reactive antibodies (PRA) the patients were divided into 3 groups: A, non-sensitized, B, moderately sensitized, and C, highly sensitized. The antigen DR3 was more frequent in sensitized (groups B + C) than in non-sensitized (group A) patients. This difference was significant on the level of P = 0.003, (Pcorr = 0.02). The antigen DR2 was more frequent in highly sensitized (group C) than in moderately sensitized (group B) patients with P = 0.002, not significant after correction for the number of investigated antigens.
Matej
H
H
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw.
Kałamarz
M
M
Nowakowska
B
B
Pacyńska
J
J
D003602:Cytotoxicity, Immunologic; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D006435:Renal Dialysis / Q000009:adverse effects*
D006684:HLA-DR Antigens; D007518:Isoantibodies