title: Enhanced acid protease activity of lysosomes from papillary thyroid carcinoma.
abstract: In vitro lysosomal acid protease activity was studied in human papillary thyroid carcinoma (n = 13). As a control, morphologically normal thyroid tissue from the same patient was used in each individual case of carcinoma. Although a marked variation may be observed between individual cases, each examined papillary thyroid carcinoma showed significantly greater activity of acid proteases, both per unit weight of wet thyroid tissue and per unit of lysosomal proteins, in comparison to the corresponding control (range, 24%-248%). In conclusion, it is suggested that enhanced proteolytic activity of lysosomal acid proteases in papillary carcinoma is probably a result of disturbance in catabolic degradation of the thyroglobulin molecule in malignantly transformed thyroid tissue.
authors.affiliation: Institute of Endocrinology, Immunology and Nutrition, Yugoslavia.
authors.forename: J
authors.initials: J
authors.lastname: Sinadinović
authors.forename: D
authors.initials: D
authors.lastname: Cvejić
authors.forename: S
authors.initials: S
authors.lastname: Savin
authors.forename: J V
authors.initials: JV
authors.lastname: Mićić
authors.forename: M
authors.initials: M
authors.lastname: Janćić-Zguricas
mesh_terms: D002291:Carcinoma, Papillary / Q000201:enzymology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D010447:Peptide Hydrolases / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000201:enzymology*
chemical_list: D010447:Peptide Hydrolases