title: Immune thrombocytopenia more than a year after allogeneic marrow transplantation due to antibodies against donor platelets with anti-PlA1 specificity: evidence for a host-derived immune reaction.
abstract: We report on a male patient transplanted from his HLA-matched sister for Ph1-chromosome positive chronic myelogenous leukaemia who developed immune thrombocytopenia more than 1 year after transplantation. The platelet antibody reacted with the platelet specific antigen PlA1 on donor platelets, and also on recipient platelets after engraftment. A presumed host-versus-donor induced thrombocytopenia was supported by Southern blot analysis using a Y-chromosome specific probe demonstrating residual host-origin cells in the patient's excised spleen.
authors.affiliation: First Medical Clinic, University of Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Panzer
authors.forename: V
authors.initials: V
authors.lastname: Kiefel
authors.forename: C R
authors.initials: CR
authors.lastname: Bartram
authors.forename: O A
authors.initials: OA
authors.lastname: Haas
authors.forename: W
authors.initials: W
authors.lastname: Hinterberger
authors.forename: C
authors.initials: C
authors.lastname: Mueller-Eckhardt
authors.forename: K
authors.initials: K
authors.lastname: Lechner
mesh_terms: D000328:Adult; D016824:Antigens, Human Platelet; D001792:Blood Platelets / Q000276:immunology; D016026:Bone Marrow Transplantation; D006789:Host vs Graft Reaction; D006801:Humans; D007154:Immune System Diseases / Q000209:etiology*; D039661:Integrin beta3; D007518:Isoantibodies / Q000276:immunology; D007519:Isoantigens / Q000276:immunology; D008297:Male; D013921:Thrombocytopenia / Q000209:etiology*; D013997:Time Factors
chemical_list: D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007518:Isoantibodies; D007519:Isoantigens