title: Pharmacotherapeutic treatment of panic disorder in patients presenting with chest pain.
abstract: While psychiatric populations with panic disorder have been shown to be responsive to several classes of psychoactive medications, there is little evidence that medical patients with panic disorder respond to similar interventions. In this non-blind, eight-week trial of alprazolam in patients presenting with chest pain and found to have panic disorder, 15 of 20 met the single criterion for improvement: a 50 percent or greater reduction in panic frequency. Several other measures were also significantly positive for those who completed the study. Furthermore, these patients reported a marginally significant drop in episodes of chest pain or discomfort. A double-blind, placebo-controlled trial is now required to test the validity of these findings.
authors.affiliation: Department of Psychiatry, University of Missouri-Columbia 65212.
authors.forename: B D
authors.initials: BD
authors.lastname: Beitman
authors.forename: I M
authors.initials: IM
authors.lastname: Basha
authors.forename: L H
authors.initials: LH
authors.lastname: Trombka
authors.forename: M A
authors.initials: MA
authors.lastname: Jayaratna
authors.forename: B
authors.initials: B
authors.lastname: Russell
authors.forename: G
authors.initials: G
authors.lastname: Flaker
authors.forename: S
authors.initials: S
authors.lastname: Anderson
mesh_terms: D000328:Adult; D000525:Alprazolam / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000150:complications / Q000188:drug therapy*; D002637:Chest Pain / Q000523:psychology*; D002986:Clinical Trials as Topic; D005239:Fear / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000187:drug effects*
chemical_list: D000525:Alprazolam