The contribution of residual leukemic cells in the graft to leukemia relapse after autologous bone marrow transplantation: mathematical considerations.
A hypothetical model for estimating the probability of leukemia development, supported by experimental evidence, provides a basis on which the conclusion can be drawn that residual leukemic cells in the graft will not contribute significantly to the occurrence of a leukemia relapse after autologous bone marrow transplantation.
Schultz
F W
FW
Radiobiological Institute TNO, Rijswijk, The Netherlands.
Martens
A C
AC
Hagenbeek
A
A
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D005260:Female; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008297:Male; D015233:Models, Statistical; D009368:Neoplasm Transplantation; D011336:Probability; D051381:Rats; D011914:Rats, Inbred BN; D012008:Recurrence; D014182:Transplantation, Autologous