Studies on the monocyte interleukin-1 and tumour necrosis factor-alpha production in patients with alcoholic liver cirrhosis.
Interleukin-1 and tumour necrosis factor-alpha activities by E. coli lipopolysaccharide-triggered monocytes were studied in patients with chronic alcoholic liver disease. Monocytes from cirrhotic patients were shown to have significantly reduced IL-1 and TNF-a activities, compared with that from age and sex matched healthy controls. These findings indicate further immunoregulatory disturbances concerning alcoholic liver cirrhosis.
Müzes
G
G
2nd Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
Deák
G
G
Láng
I
I
González-Cabello
R
R
Gergely
P
P
Fehér
J
J
D000328:Adult; D001681:Biological Assay; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000097:blood*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000276:immunology*; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D012016:Reference Values; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha