title: [Ion pair HPLC determination of p-aminobenzoic acid as an impurity in procaine and procainamide hydrochlorides].
abstract: A simple, specific and sensitive high-performance liquid chromatographic method for the determination of p-amino benzoic acid (PABA) as impurity in procaine and procainamide hydrochlorides has been developed. The compounds were chromatographed on reversed phase C-18 using water-methanol-acetonitrile solvent system containing sodium lauryl sulphate ion-pair reagent.
authors.affiliation: Istituto di Tecnica Farmaceutica, Università degli Studi, Trieste.
authors.forename: V
authors.initials: V
authors.lastname: Maurich
authors.forename: F
authors.initials: F
authors.lastname: Collino
authors.forename: M
authors.initials: M
authors.lastname: Zacchigna
authors.forename: M
authors.initials: M
authors.lastname: Moneghini
mesh_terms: D010129:4-Aminobenzoic Acid / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D011342:Procainamide / Q000032:analysis*; D011343:Procaine / Q000032:analysis*
chemical_list: D011343:Procaine; D011342:Procainamide; D010129:4-Aminobenzoic Acid
vernacular_title: Determinazione dell'acido p-amino-benzoico quale impurezza nei cloridrati di procaina e procainamide mediante HPLC a coppia ionica.