title: Pharmacokinetics of cefotaxime and desacetylcefotaxime in the newborn.
abstract: A study of the pharmacokinetic parameters of cefotaxime (CTX) and desacetylcefotaxime (dCTX) in newborns was conducted; the former is commonly used for neonatal infections. The elimination half life of CTX correlated with gestational age (GA) and postnatal age (PNA). Elimination of dCTX was longer permitting a synergistic or additive effect with CTX against Gram-negative bacteria. CTX is indicated in the treatment of neonatal sepsis because of the increasing resistance of Escherichia coli to ampicillin and its good efficacy against group B streptococcus.
authors.affiliation: Neonatal Unit, Hopital Robert Debre, Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Aujard
authors.forename: F
authors.initials: F
authors.lastname: Brion
authors.forename: E
authors.initials: E
authors.lastname: Jacqz-Aigrain
authors.forename: M C
authors.initials: MC
authors.lastname: Kasse
authors.forename: P
authors.initials: P
authors.lastname: Chretien
authors.forename: C
authors.initials: C
authors.lastname: Criqui
authors.forename: H
authors.initials: H
authors.lastname: Mathieu
mesh_terms: D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000494:pharmacology; D004334:Drug Administration Schedule; D004926:Escherichia coli / Q000187:drug effects; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D013292:Streptococcus agalactiae / Q000187:drug effects
chemical_list: C029281:desacetylcefotaxime; D002439:Cefotaxime