title: High-dose chemotherapy and autologous marrow transplantation for esthesioneuroblastoma and sinonasal undifferentiated carcinoma.
abstract: Eight patients with recurrent esthesioneuroblastoma or sinonasal undifferentiated carcinoma of the nasal or sinus cavities were treated with high-dose chemotherapy and autologous bone marrow transplantation. All patients had stage C disease initially and had received extensive prior conventional treatment with surgery, radiotherapy, and chemotherapy. Two patients achieved prolonged relapse-free survival for 18+ and 60 months. The latter patient relapsed at 60 months, but died of progressive disease after a second transplant. Two additional patients remain alive without disease progression at 17+ and 31+ months posttransplant. No deaths occurred secondary to toxicity. Progression of tumor accounted for failure in five patients. High-dose chemotherapy and autologous bone marrow transplantation should be considered as a salvage regimen for selected patients who fail conventional therapy for these diseases.
authors.affiliation: Department of Medicine, University of Virginia, Charlottesville 22908.
authors.forename: F M
authors.initials: FM
authors.lastname: Stewart
authors.forename: H M
authors.initials: HM
authors.lastname: Lazarus
authors.forename: P A
authors.initials: PA
authors.lastname: Levine
authors.forename: K A
authors.initials: KA
authors.lastname: Stewart
authors.forename: I A
authors.initials: IA
authors.lastname: Tabbara
authors.forename: C A
authors.initials: CA
authors.lastname: Spaulding
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D002277:Carcinoma / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000401:mortality / Q000628:therapy*; D009669:Nose Neoplasms / Q000401:mortality / Q000628:therapy*; D010255:Paranasal Sinus Neoplasms / Q000401:mortality / Q000628:therapy*; D014182:Transplantation, Autologous