title: Flunixin meglumine and flurbiprofen in cows with experimental Escherichia coli mastitis.
abstract: The effect of flunixin meglumine and flurbiprofen on the course of experimental Escherichia coli mastitis was examined. Nine cows (within one month post partum) were inoculated intramammarily with 20 x 10(5) viable E coli in both rear quarters. Three cows remained untreated (controls); three cows received three injections of flunixin meglumine and three cows received flurbiprofen as two intravenous infusions. Flunixin meglumine and flurbiprofen were initially given before clinical signs were observed. Treatment was repeated if the cows' temperature increased by more than 1 degree C. In the untreated cows, rectal temperature and heart rate increased from three hours after infection, and rumen motility (both frequency and amplitude) decreased from four hours after infection. Treatment with flunixin meglumine or flurbiprofen almost completely abolished the febrile response during the first nine hours after infection, and the decrease in rumen motility was less pronounced in the treated animals. These results suggest that the decrease in rumen motility during E coli mastitis is at least partly due to a mechanism involving prostaglandin.
authors.affiliation: Department of Herd Health and Reproduction, Utrecht, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Lohuis
authors.forename: W
authors.initials: W
authors.lastname: Van Leeuwen
authors.forename: J H
authors.initials: JH
authors.lastname: Verheijden
authors.forename: A
authors.initials: A
authors.lastname: Brand
authors.forename: A S
authors.initials: AS
authors.lastname: Van Miert
mesh_terms: D000818:Animals; D001831:Body Temperature; D002417:Cattle; D003002:Clonixin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D005260:Female; D005480:Flurbiprofen / Q000627:therapeutic use*; D006339:Heart Rate; D008414:Mastitis, Bovine / Q000188:drug therapy* / Q000503:physiopathology; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000503:physiopathology; D009539:Nicotinic Acids / Q000627:therapeutic use*; D011422:Propionates / Q000627:therapeutic use*; D012417:Rumen / Q000503:physiopathology
chemical_list: D009539:Nicotinic Acids; D011422:Propionates; D005480:Flurbiprofen; C014558:flunixin meglumine; D003002:Clonixin