title: Acute effects of instillation of surfactant in severe respiratory distress syndrome.
abstract: Doppler ultrasound measurements of pulmonary blood flow in 20 babies with severe respiratory distress syndrome treated in a randomised controlled trial of surfactant replacement showed that the immediate improvement of oxygenation was not associated with a significant increase in pulmonary blood flow. Reduction in ventilator settings and increases in the extent of chest wall movements measured by a cardiorespiratory monitor suggested that the improvement after surfactant had been given was a result of alveolar stabilisation and increased pulmonary compliance. Further simultaneous studies of pulmonary blood flow and pulmonary compliance are needed to confirm these findings.
authors.affiliation: Department of Child Health, Queen's University of Belfast.
authors.forename: H L
authors.initials: HL
authors.lastname: Halliday
authors.forename: F B
authors.initials: FB
authors.lastname: McCord
authors.forename: B G
authors.initials: BG
authors.lastname: McClure
authors.forename: M M
authors.initials: MM
authors.lastname: Reid
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D007231:Infant, Newborn; D010100:Oxygen / Q000097:blood / Q000502:physiology; D010313:Partial Pressure; D011650:Pulmonary Alveoli / Q000378:metabolism; D011652:Pulmonary Circulation; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D011897:Random Allocation; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*
chemical_list: D011663:Pulmonary Surfactants; D010100:Oxygen