title: Cyclosporine-associated microangiopathic hemolytic anemia in a renal transplant recipient.
abstract: A case of microangiopathic hemolytic anemia (MHA) associated with the immunosuppressive agent, cyclosporine, is reported herein. The patient manifested anemia with red blood cell fragmentation, hypertension, thrombocytopenia, elevation of serum LDH levels and glomerular capillary thromboses within a few days of his transplantation. Extensive treatments with urokinase and heparin proved ineffective and graftectomy was performed 7 days after his transplantation. Immunofluorescent staining failed to show immunoglobulin (IgG or IgM) or complement (C3) deposition within the glomeruli, which discriminated MHA from acute humoral-vascular rejection.
authors.affiliation: Second Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yoshimura
authors.forename: T
authors.initials: T
authors.lastname: Oka
authors.forename: Y
authors.initials: Y
authors.lastname: Ohmori
authors.forename: I
authors.initials: I
authors.lastname: Aikawa
authors.forename: T
authors.initials: T
authors.lastname: Yasumura
authors.forename: S
authors.initials: S
authors.lastname: Matsui
authors.forename: T
authors.initials: T
authors.lastname: Hamashima
authors.forename: C J
authors.initials: CJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000743:Anemia, Hemolytic / Q000139:chemically induced*; D003524:Cyclosporins / Q000009:adverse effects*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male
chemical_list: D003524:Cyclosporins