[Interaction of immune complexes and their leukocyte receptors: regulation by the complement system and by cyclophosphamide].
During the course of this investigation we have studied different aspects related to the interaction between immune complexes (CI) and their cellular receptors for the Fc-fragment of IgG (RFc gamma). Our first approach was to demonstrate that the alternative pathway of complement is the main one responsible for the CI-dissociation from their receptors of human peripheral mononuclear cells. This modulatory effect was studied throughout the functional restoration of antibody dependent cellular cytotoxicity (CCCDA), which is a mechanism susceptible to Cl-inhibition. The results suggest that the levels of circulating Cl do not necessarily correlate with the tissue damage they produce. Secondly, we have demonstrated that cyclophosphamide (Cy), which is a potent immunomodulating drug which has been used for the treatment of diseases characterized by high levels of Cl, enhances the capacity of the mononuclear phagocytic system to remove IgG-particulate complexes in mice. Finally, we have described a nonspecific cytotoxic system triggered by Cl against different target cells, through a mechanism that involves the reactive metabolites of O2.
Isturiz
M A
MA
Giordano
M
M
Geffner
J R
JR
Palermo
M S
MS
Serebrinsky
G
G
D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D003167:Complement Activation / Q000502:physiology*; D003170:Complement Pathway, Alternative / Q000502:physiology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis; D011961:Receptors, Fc / Q000187:drug effects / Q000378:metabolism*
D000936:Antigen-Antibody Complex; D011961:Receptors, Fc; D003520:Cyclophosphamide
Interacción de los complejos inmunes y sus receptores leucocitarios: su regulación por el sistema complemento y la ciclofosfamida.