Alz-50 immunoreactivity in the neonatal rat: changes in development and co-distribution with MAP-2 immunoreactivity.
Alz-50 is a monoclonal antibody that recognizes pathological alterations in Alzheimer's disease. It has recently been noted also to mark some subplate neurons in human infants under the age of 2 years. We now report that Alz-50 recognizes many neurons in the normal neonatal rat in a pattern that changes with development. Immunoreactivity decreases substantially in intensity as the rat matures. This immunoreactivity co-distributes with microtubule-associated protein-2 (MAP-2) immunoreactivity in terms of topography, cellular localization and changes over the developmental time-course. This observation raises the possibility of exploring cytologic triggers that may lead to re-expression of Alz-50 immunoreactivity in aging and in pathological conditions.
Hamre
K M
KM
Department of Anatomy, University of Iowa College of Medicine, Iowa City 52242.
Hyman
B T
BT
Goodlett
C R
CR
West
J R
JR
Van Hoesen
G W
GW
D000544:Alzheimer Disease / Q000276:immunology; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism*; D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis* / Q000378:metabolism; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D001923:Brain Chemistry; D007124:Immunoenzyme Techniques; D008869:Microtubule-Associated Proteins / Q000032:analysis / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
C056167:Alzheimer's disease antigen; D000911:Antibodies, Monoclonal; D000941:Antigens; D008869:Microtubule-Associated Proteins