title: The role of free radicals and eicosanoids in the pathogenetic mechanism underlying ischemic brain edema.
abstract: Results of our consecutive study on the pathogenic mechanism underlying ischemic brain edema are summarized in this paper. Pertinent findings are as follows: (1) there is a close correlation between the influxes of water and sodium following ischemia; (2) the edema fluid can be regarded as the ultrafiltrate of serum; (3) there is a significant increase in the brain content of HETEs following ischemia; (4) the lipoxygenase activity of brain microvessels is increased following ischemia; (5) the lipoxygenase activity as well as the Na+, K+-ATPase activity of brain microvessels are enhanced by a hydroperoxide, 15-HPETE; (6) inhibition of Na+, K+-ATPase of brain microvessels by intraarterial infusion of ouabain resulted in a significant decrease in edema formation; and (7) not the cyclooxygenase, but the lipoxygenase pathway seems to be involved in the enhancement of microvessel Na+, K+-ATPase. Lipoxygenase(s) and Na+-K+-ATPase of brain microvessels, the activities of which are enhanced by an increased level of free radicals and/or hydroperoxides, may play a significant role in the occurrence of ischemic brain edema.
authors.affiliation: Department of Neurosurgery, Saitama Medical Center, Saitama Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Asano
authors.forename: T
authors.initials: T
authors.lastname: Koide
authors.forename: O
authors.initials: O
authors.lastname: Gotoh
authors.forename: H
authors.initials: H
authors.lastname: Joshita
authors.forename: T
authors.initials: T
authors.lastname: Hanamura
authors.forename: T
authors.initials: T
authors.lastname: Shigeno
authors.forename: K
authors.initials: K
authors.lastname: Takakura
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D002415:Cats; D004537:Eicosanoic Acids / Q000378:metabolism*; D005609:Free Radicals; D002546:Ischemic Attack, Transient / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D012964:Sodium / Q000502:physiology
chemical_list: D004537:Eicosanoic Acids; D005609:Free Radicals; D012964:Sodium