title: Systemic vasculitis in association with human immunodeficiency virus infection.
abstract: Fourteen cases of vasculitis associated with human immunodeficiency virus infection have thus far been described. Five of these cases may be classified as angiocentric immunoproliferative disorders, including benign lymphocytic angiitis, lymphomatoid granulomatosis, and angiocentric lymphoma. We report a case of benign lymphocytic angiitis of T cell lineage. Extensive studies found no evidence of viral antigens in the inflammatory infiltrates, and immunologic evaluation of the pathologic lesions revealed the infiltrating cells to be predominantly CD3+, CD8+, CD4-. A significant number of these lymphocytes demonstrated a deletion of T cell antigen receptor determinants. We believe that in certain cases of human immunodeficiency virus disease, there occurs a spectrum of lymphoproliferative disorders with angiocentric features that lead to the clinical picture of systemic necrotizing vasculitis. Clinicians should be aware of this association.
authors.affiliation: Department of Rheumatic and Immunologic Disease, Cleveland Clinic Foundation, OH 44106.
authors.forename: L H
authors.initials: LH
authors.lastname: Calabrese
authors.forename: M
authors.initials: M
authors.lastname: Estes
authors.forename: B
authors.initials: B
authors.lastname: Yen-Lieberman
authors.forename: M R
authors.initials: MR
authors.lastname: Proffitt
authors.forename: R
authors.initials: R
authors.lastname: Tubbs
authors.forename: A J
authors.initials: AJ
authors.lastname: Fishleder
authors.forename: K H
authors.initials: KH
authors.lastname: Levin
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015483:HIV Antibodies / Q000032:analysis; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009132:Muscles / Q000276:immunology / Q000473:pathology; D009206:Myocardium / Q000276:immunology / Q000473:pathology; D013497:Sural Nerve / Q000276:immunology / Q000473:pathology; D014657:Vasculitis / Q000150:complications* / Q000473:pathology
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D015483:HIV Antibodies