Synthesis and biological activity of a cyclic hexapeptide related to peptide T.
The cyclo [Thr-Thr-Thr-Tyr-Asn-Thr] hexapeptide related to peptide T, H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH, competitor of the Human Immunodeficiency Virus in the binding to human T cells, was synthesized and tested for its ability to stimulate monocyte migration (chemotaxis). The new cyclic derivative showed negligible biological activity.
Bianchi
S
S
Dipartimento Scienze Farmaceutiche, Università di Ferrara, Italy.
Scaranari
V
V
Tomatis
R
R
D000595:Amino Acid Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D009000:Monocytes / Q000187:drug effects; D015717:Peptide T / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology
D015717:Peptide T