title: Endocrine cell carcinoma (carcinoid) of the gallbladder.
abstract: We report two cases of endocrine cell carcinoma of the gallbladder associated with adenocarcinoma. The patients were women with numerous gallstones. Histologically, the tumors consisted of adenocarcinoma and endocrine cell carcinoma. An apparent transition was noted between the two types. Tumor cells of both the endocrine cell carcinoma and the adenocarcinoma were argyrophilic. In one case the tumor was surrounded by metaplastic mucosa; in the other case, it was surrounded by dysplastic and metaplastic mucosa. The nonneoplastic mucosae also contained argyrophil cells in varying number. These findings suggest that endocrine cell carcinoma of the gallbladder is derived from metaplastic epithelium of the gallbladder.
authors.affiliation: Department of Pathology, Hiroshima University Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Nakajo
authors.forename: N
authors.initials: N
authors.lastname: Miyoshi
authors.forename: S
authors.initials: S
authors.lastname: Nakai
authors.forename: E
authors.initials: E
authors.lastname: Tahara
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D002276:Carcinoid Tumor / Q000473:pathology*; D005260:Female; D005706:Gallbladder Neoplasms / Q000473:pathology*; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000473:pathology*