[Molecular biology of the inhibitory synapse].
The amino acids glycine and gamma-aminobutyric acid are the major inhibitory neurotransmitter substances in the central nervous system of all vertebrates. Due to an increase of chloride ion conductance of the postsynaptic membrane these neurotransmitters inhibit the excitability of the nerve cell. During the last years the receptor proteins mediating the action of glycine and gamma-aminobutyric acid were characterized in more detail by biochemical and molecular biology techniques. The present data show that all neurotransmitter receptors which alter the ion permeability of the postsynaptic membrane are members of a large protein family which has evolved from a common precursor.
Betz
H
H
Zentrum für Molekulare Biologie, Universität Heidelberg.
D000818:Animals; D006801:Humans; D008967:Molecular Biology; D013569:Synapses / Q000502:physiology*
Molekularbiologie der inhibitorischen Synapse.