Magnetically controlled targeted micro-carrier systems.
Magnetically controlled targeted drug delivery systems are aimed at concentrating drugs at a defined target site, with the aid of a magnetic field. This technique has been developed specifically for directing drugs away from the reticuloendothelial system (RES). Literature on this topic suggests that these delivery systems are capable of altering the distribution of chemotherapeutic agents in the body. Hence these delivery devices offer the possibility of improving the therapeutic efficacy of the associated drugs. This paper reviews the work done to date towards the development and evaluation of biodegradable and non-biodegradable magnetic targeted drug delivery systems and outlines their future prospects and limitations in cancer chemotherapy.
Gupta
P K
PK
Department of Pharmacy, University of Otago, Dunedin, New Zealand.
Hung
C T
CT
D000418:Albumins / Q000008:administration & dosage; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001673:Biodegradation, Environmental; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives; D003487:Cyanoacrylates / Q000008:administration & dosage; D004337:Drug Carriers / Q000378:metabolism; D004912:Erythrocytes; D008081:Liposomes / Q000008:administration & dosage; D008280:Magnetics; D008863:Microspheres; D013213:Starch / Q000008:administration & dosage
D000418:Albumins; D000970:Antineoplastic Agents; D003487:Cyanoacrylates; D004337:Drug Carriers; D008081:Liposomes; C013517:ethyl cellulose; D002482:Cellulose; D013213:Starch