title: Amine peroxides as potential antimalarials.
abstract: Six model amine peroxides (4-9) were synthesized as targeted antimalarial oxidants. They were approximately 1 order of magnitude more potent than tert-butyl hydroperoxide (3) in vitro against Plasmodium falciparum, but like 3, they were inactive in vivo against Plasmodium berghei.
authors.affiliation: Department of Medicinal Chemistry, Walter Reed Army Institute of Research, Washington, D.C. 20307.
authors.forename: J L
authors.initials: JL
authors.lastname: Vennerstrom
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis*; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003959:Diamines / Q000138:chemical synthesis / Q000494:pharmacology; D010545:Peroxides / Q000138:chemical synthesis* / Q000494:pharmacology; D010962:Plasmodium berghei / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003959:Diamines; D010545:Peroxides; C058103:hexamethylenetriperoxidediamine