title: Intracerebroventricular administration of insulin attenuates retrieval of a passive avoidance response in rats.
abstract: The effect of intracerebroventricularly applied insulin on one-trial learning passive avoidance behaviour has been studied in rats. Treatment with 10.3 pmole insulin 1 hr before the 24 hr retention test attenuated passive avoidance behaviour at both the 24 hr and 48 hr retention trials. The data suggest that insulin may play a role in processes relating to the retrieval of information stored in the brain.
authors.affiliation: Institute of Physiology, Medical Academy Magdeburg, German Democratic Republic.
authors.forename: H
authors.initials: H
authors.lastname: Schwarzberg
authors.forename: H G
authors.initials: HG
authors.lastname: Bernstein
authors.forename: M
authors.initials: M
authors.lastname: Reiser
authors.forename: O
authors.initials: O
authors.lastname: Günther
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D007276:Injections, Intraventricular; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
chemical_list: D007328:Insulin