Dopamine may influence striatal GABA release via three separate mechanisms.
We have examined the influence of dopamine (DA) on the spontaneous and electrically evoked release of gamma-aminobutyric acid (GABA) from striatal slices prepared from rat brain. We observe that DA has at least 3 separate effects on GABA release. These effects include both excitatory and inhibitory influences, and involve DA receptors of the D1- and D2-subtypes as well as a mechanism that is not mediated by either of these receptors.
Bernath
S
S
Department of Behavioral Neuroscience, University of Pittsburgh, PA 15260.
Zigmond
M J
MJ
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000494:pharmacology*; D004558:Electric Stimulation; D004873:Ergolines / Q000494:pharmacology; D066298:In Vitro Techniques; D019257:Quinpirole; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D013469:Sulpiride / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D001552:Benzazepines; D004873:Ergolines; D011954:Receptors, Dopamine; D019257:Quinpirole; D005680:gamma-Aminobutyric Acid; D013469:Sulpiride; D004298:Dopamine