[Detection of cyclosporin A in breast milk--is breast feeding contraindicated?].
Cyclosporin A (CyA) was measured simultaneous in breast milk and maternal and fetal blood with a new monoclonal specific radioimmunoassay in a patient who was treated with Cyclosporin A during pregnancy because of kidney transplantation. CyA-levels in breast milk were 15 to 90% higher than in maternal blood. In case of breast feeding a child would take up less than 5 percent of an immunosuppressive dose. However, we would recommend ablactation because of the toxicity and the unknown side effects of CyA for the child's immunologic system.
Behrens
O
O
Frauenklinik, Medizinischen Hochschule Hannover.
Kohlhaw
K
K
Günter
H
H
Wonigeit
K
K
Niesert
S
S
D000328:Adult; D001942:Breast Feeding; D003524:Cyclosporins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008895:Milk, Human / Q000378:metabolism*
D003524:Cyclosporins
Nachweis von Cyclosporin A in der Muttermilch--ist Stillen kontraindiziert?