title: [Antenatal diagnosis of holoprosencephaly and its consequences. Apropos of 2 cases].
abstract: Cyclops represents the worst form of a rare malformation of the brain and face: holoprosencephaly. Two cases are reported, including one that was diagnosed at the 23rd week of pregnancy. Now, ultrasonography makes it possible to diagnose early; as soon as the 15th week of gestation. Ultrasound diagnosis is based on hypotelorism and anomalies of the mid-line, with or without facial abnormalities. The outcome is always poor. This malformation is associated with various conditions and a complete assessment, including the karyotype, morphologic studies of the fetus and of his family, and search for related minor facial dysmorphias (median labial or cleft palate with, with a single upper incisor) is mandatory. The condition recurs in 2 to 50% of cases depending on various associated conditions and on the family histories.
authors.affiliation: Départment Mère-Enfant, Centre Hospitalier Louise-Michel, Evry.
authors.forename: R
authors.initials: R
authors.lastname: Nguyen Tan Lung
authors.forename: Y
authors.initials: Y
authors.lastname: Blanchon
authors.forename: N
authors.initials: N
authors.lastname: Ciraru-Vigneron
authors.forename: A
authors.initials: A
authors.lastname: Rabbe
authors.forename: E
authors.initials: E
authors.lastname: Sauvanet
authors.forename: J
authors.initials: J
authors.lastname: Barrier
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis*; D000328:Adult; D001921:Brain / Q000002:abnormalities*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014463:Ultrasonography
vernacular_title: Le diagnostic anténatal de l'holoprosencéphalie et ses conséquences. A propos de 2 observations.