Suppression of malaria-induced autoimmunity by immunization with cryoglobulins.
Cryoglobulins obtained from malaria-infected (Plasmodium berghei berghei) Balb/c mice were administered intraperitoneally to naive Balb/c mice. Ten days or 9 months following cryoglobulin administration, the naive mice were infected with malaria. Comparison of sera from cryoglobulin-treated malaria-infected mice with sera from control infected mice revealed that pretreatment with cryoglobulins resulted in (1) reduced levels of circulating immune complexes; (2) reduced levels of autoantibodies reactive with nuclear and cytoplasmic antigens; and (3) suppressed development of cryoglobulinemia. Furthermore, the effect of cryoglobulins was long lasting, suggesting that recipient mice may have been actively immunized against autoantibody production.
Fawcett
P T
PT
Alfred I. duPont Institute, Wilmington, Delaware 19899.
Fawcett
L B
LB
Doughty
R A
RA
Coleman
R M
RM
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000008:administration & dosage / Q000096:biosynthesis / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology* / Q000517:prevention & control; D001769:Blood / Q000469:parasitology; D003450:Cryoglobulins / Q000008:administration & dosage / Q000276:immunology*; D005260:Female; D007108:Immune Tolerance; D007116:Immunization, Passive; D008288:Malaria / Q000150:complications / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010962:Plasmodium berghei
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D003450:Cryoglobulins