Negative inotropic and calcium antagonistic activity of alkyl and arylalkyl phosphonates.
Several alkyl and arylalkyl diethylphosphonates related to fostedil have been synthetized and tested for negative inotropic activity (isolated guinea pig left atrium) and Ca++ antagonistic activity (isolated guinea pig aortic strips). The results show that negative inotropic and Ca++ antagonistic activity might depend from different molecular features.
Bellucci
C
C
Dipartimento di Scienze Farmaceutiche dell'Universita, Firenze, Italy.
Gualtieri
F
F
Scapecchi
S
S
Teodori
E
E
Budriesi
R
R
Chiarini
A
A
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology
D002121:Calcium Channel Blockers; D009943:Organophosphorus Compounds; D011189:Potassium Chloride