title: O-glycosylation pathway for mucin-type glycoproteins.
abstract: O-glycosylation is the post-translational process whereby carbohydrate is added to hydroxylated amino acids of proteins. The major O-glycosylation pathway in animal cells is involved in the synthesis of oligosaccharides linked by N-acetylgalactosamine to serine or threonine residues in 'mucin-type' proteins or their analogs. In this review, we discuss the evidence for the cellular localization of the biosynthetic steps in this pathway and propose a simplified, consensus version. We also propose variations of the simple pathway to account for its heterogeneity and variability in different cell types and differentiation states.
authors.forename: K L
authors.initials: KL
authors.lastname: Carraway
authors.forename: S R
authors.initials: SR
authors.lastname: Hull
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006031:Glycosylation; D006801:Humans; D009077:Mucins / Q000235:genetics*; D009369:Neoplasms / Q000378:metabolism; D009844:Oligosaccharides / Q000378:metabolism; D011499:Protein Processing, Post-Translational
chemical_list: D009077:Mucins; D009844:Oligosaccharides