title: [Aztreonam versus tobramycin in acute pyelonephritis. A comparative study].
abstract: We performed a comparative study between the monobactam antibiotic aztreonam and the aminoglycoside tobramycin in patients diagnosed as having acute pyelonephritis. The respective doses were 1 gr. IM daily for 7 days, and 100 mgr. IM q 12 h for the same period of time. Clinically, 100% of uncomplicated acute pyelonephritis and 87.5% of complicated infections cured with aztreonam. Tobramycin achieved an 80% cure rate for both types of infections. Microbiologically aztreonam was effective in all uncomplicated acute pyelonephritis, and in 69.56% of the complicated cases (overall microbiological cure rate = 78.7%). The therapeutic failures were ascribable to infections from S. faecalis, an organism naturally resistant to aztreonam. Thus, the microbiological cure rate was 84.2% in complicated pyelonephritis from organisms sensitive to this antimicrobial. The microbiological cure rate for tobramycin was 70% in acute uncomplicated, and 80% in complicated infections. We observed a good clinical and biological tolerance to both antimicrobials. No side effects were observed. Serum and blood biochemical analyses, and coagulation tests revealed no changes.
authors.forename: J
authors.initials: J
authors.lastname: Gallego
authors.forename: J F
authors.initials: JF
authors.lastname: Jiménez Cruz
authors.forename: M
authors.initials: M
authors.lastname: Gobernado
authors.forename: B
authors.initials: B
authors.lastname: Llopis
authors.forename: J
authors.initials: J
authors.lastname: Vidal
authors.forename: G
authors.initials: G
authors.lastname: Server
authors.forename: J L
authors.initials: JL
authors.lastname: Ruiz
authors.forename: C
authors.initials: C
authors.lastname: David Vera
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001398:Aztreonam / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011704:Pyelonephritis / Q000188:drug therapy*; D014031:Tobramycin / Q000627:therapeutic use*
chemical_list: D001398:Aztreonam; D014031:Tobramycin
vernacular_title: Aztrenonam versus tobramicina en pielonefritis agudas. Estudio comparativo.