Damage to DNA strand and the effects of anticancer drugs.
Cancer chemotherapy is, in a sense, similar to the treatment of infectious disease with antibiotics. The main mechanism of action is on DNA and its precursor, and in the process that anticancer drugs exert the effect on cancer cells, the cells always have abnormal metabolism or destruction of DNA. The main cellular target of most alkylating agents, or anticancer antibiotics is DNA, however, among the anticancer drug newly synthesized, there are some compounds which exert the action on DNA. Quinocarmycin, KT6149, which is a derivative of MMC, YM534, which possesses a platelet agglutinating activity, and MCNU, a nitrosourea compound were studied on the anticancer activity and on damage to DNA strand, and it was found that the lethal effect was deeply concerned with single strand scission of DNA.
Kanamaru
R
R
Ishioka
C
C
Konishi
Y
Y
Ishikawa
A
A
Shibata
H
H
Wakui
A
A
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002208:Caproates / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000187:drug effects*; D004249:DNA Damage; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D007546:Isoquinolines / Q000494:pharmacology; D008937:Mitomycins / Q000494:pharmacology; D009607:Nitrosourea Compounds / Q000494:pharmacology
D000970:Antineoplastic Agents; D002208:Caproates; D007093:Imidazoles; D007546:Isoquinolines; D008937:Mitomycins; D009607:Nitrosourea Compounds; C057625:KW 2149; C038710:quinocarcin; D004247:DNA; C061529:YM 534; C020766:ranimustine