Effects of ovarian hormones on eating behaviors, body weight, and glucoregulation in rhesus monkeys.
The influences of ovarian hormones on food intake, taste preferences, and glucoregulation were examined in intact and ovariectomized rhesus monkeys. Intake of intact monkeys was lowest in the preovulatory stage of the cycle, when estrogen levels are elevated, and exogenous estradiol transiently suppressed food intake of ovariectomized monkeys in a dose-related manner, confirming previous observations. Progesterone treatment did not affect food intake when given alone, but it did attenuate the effect of estradiol when both hormones were given concurrently. Preferences for sweet solutions were not detectably influenced by chronic treatment with estradiol or progesterone, and compensatory responses to ingestion of sugar were unaltered by hormone treatment. Glucose tolerance tests did not reveal significant influences of ovarian hormones on glycemia, but insulin levels were elevated during periods of progesterone treatment. These results do not support the suggestion that fluctuations in caloric intake during the menstrual cycle are secondary to changes in taste preference or glucoregulation. However, possible changes in sweet preference and glucoregulation shortly after initiation of estrogen treatment, i.e., during the time of suppressed food intake, remain to be examined.
Kemnitz
J W
JW
Wisconsin Regional Primate Research Center, University of Wisconsin-Madison 53715-1299.
Gibber
J R
JR
Lindsay
K A
KA
Eisele
S G
SG
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight; D004958:Estradiol / Q000502:physiology*; D004971:Estrus / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D007328:Insulin / Q000097:blood; D008253:Macaca mulatta; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology*; D011374:Progesterone / Q000502:physiology*; D013649:Taste / Q000502:physiology
D001786:Blood Glucose; D007328:Insulin; D011374:Progesterone; D004958:Estradiol