[Treatment of glaucoma chronicum simplex with a combination of 0.5 percent timolol with 0.5 percent adrenaline plus 0.3 percent guanethidine].
The effect on the intraocular pressure of patients with primary open-angle glaucoma of a combination of timolol 0.5% with epinephrine 0.5% plus guanethidine 3% was studied and compared with the effects of timolol alone, of epinephrine 0.5% plus guanethidine 3%, and of other glaucoma drugs. The combination of timolol 0.5% with epinephrine 0.5% plus guanethidine 3% had a stronger effect on intraocular pressure (reduction 10.9 +/- 1.1 mm Hg) than epinephrine 0.5% plus guanethidine 3% (7.6 +/- 0.9 mm Hg) or timolol alone (5.8 +/- 1.1 mm Hg) or other glaucoma drugs. However, when the three substances are administered in combination therapy may show an addition of both pressure-lowering and side effects.
Pfeiffer
N
N
Universitäts-Augenklinik Freiburg.
Grehn
F
F
D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000008:administration & dosage*; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006145:Guanethidine / Q000008:administration & dosage*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D009883:Ophthalmic Solutions; D012189:Retrospective Studies; D013999:Timolol / Q000008:administration & dosage*
D009883:Ophthalmic Solutions; D013999:Timolol; D004837:Epinephrine; D006145:Guanethidine
Behandlung des Glaucoma chronicum simplex durch die Kombination von Timolol 0,5% mit Adrenalin 0,5% plus Guanethidin 3%.