Frequency of angiographic detection and quantitative assessment of coronary arterial disease one and three years after cardiac transplantation.
The reported high incidence of coronary atherosclerosis in many transplant series led us to critically review our experience in 83 patients who have had selective coronary angiography at greater than or equal to 1 years after transplantation. Angiograms were reviewed for evidence of coronary vascular disease, and quantitative analysis of multiple coronary artery segments was performed in serial films. Qualitative analysis revealed only 3 of 83 patients with any angiographic abnormality at follow-up, 1 with minimal luminal irregularities in the right coronary artery at 1 year, a second with a 50% diameter stenosis of the proximal left anterior descending artery and minimal irregularity of the proximal circumflex artery at 1 year and a third patient who developed a new 30% diameter eccentric proximal right coronary artery stenosis at 3-year follow-up. The cumulative incidence of graft vascular disease assessed angiographically was therefore 2% at 1 year and 4% at 3 years. Quantitative analysis, however, showed a significant decrease in coronary artery luminal diameter over time. The mean left main coronary artery diameter decreased from 5.4 +/- 0.9 mm at 1 year to 4.7 +/- 0.8 mm at 3 years (p = 0.0007).(ABSTRACT TRUNCATED AT 250 WORDS)
O'Neill
B J
BJ
Division of Cardiology, University Hospital, London, Ontario, Canada.
Pflugfelder
P W
PW
Singh
N R
NR
Menkis
A H
AH
McKenzie
F N
FN
Kostuk
W J
WJ
D001794:Blood Pressure; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D003404:Creatinine / Q000097:blood; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000187:drug effects; D016027:Heart Transplantation; D006801:Humans; D007165:Immunosuppression Therapy; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D014280:Triglycerides / Q000097:blood
D010975:Platelet Aggregation Inhibitors; D014280:Triglycerides; D003404:Creatinine