Biology of regional body fat distribution: relationship to non-insulin-dependent diabetes mellitus.
Our studies support the view that body fat distribution and the accompanying metabolic abnormalities could be exacerabated by variability in the androgenic/estrogenic balance. Sensitivity to the androgenic milieu might be initiated by an early developmental aberration in sexual dimorphism. The possible direct and indirect sites of interaction between androgenic activity and the abnormal metabolic pathways in upper body obesity are summarized in Figure 19.
Kissebah
A H
AH
Department of Medicine, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee 53005.
Peiris
A N
AN
D000273:Adipose Tissue / Q000378:metabolism / Q000503:physiopathology*; D000728:Androgens / Q000378:metabolism; D001794:Blood Pressure; D003920:Diabetes Mellitus / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000502:physiology; D008074:Lipoproteins / Q000378:metabolism; D008659:Metabolic Diseases / Q000378:metabolism / Q000503:physiopathology; D009765:Obesity
D000728:Androgens; D004967:Estrogens; D007328:Insulin; D008074:Lipoproteins; D005947:Glucose