Correlations between magnesium and heavy metals in blood and sixteen tissues of rabbits.
Spearman correlations between magnesium and heavy metals (lead and cadmium) were investigated in blood and 16 tissues of four groups of rabbits receiving different diets: I (controls), II (water with 9.66 mumols/litre of lead), III (atherogenic), and IV (atherogenic + 9.66 mumols/litre of lead). On days 1, 42 and 172 of the experiment there were no significant correlations between magnesium and lead in rabbit blood. After 25 weeks, among the 16 tissues studied only liver presented a significant positive correlation (P less than 0.01) between magnesium and lead. Correlations between magnesium and cadmium were significantly positive (P less than 0.01) in lung, liver, adrenal gland and spleen. It is thus possible that a rise in magnesium in tissues with high metabolic activity serve to combat the harmful effects of an increase in these heavy metals.
Speich
M
M
Laboratoire de Biochimie, Faculté de Pharmacie, Nantes, France.
Auget
J L
JL
Arnaud
P
P
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D002104:Cadmium / Q000097:blood* / Q000378:metabolism; D004032:Diet; D004036:Diet, Atherogenic; D005260:Female; D007854:Lead / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008274:Magnesium / Q000097:blood* / Q000378:metabolism; D008297:Male; D011817:Rabbits; D013154:Spleen / Q000378:metabolism
D002104:Cadmium; D007854:Lead; D008274:Magnesium