[Ability of granulocytes to reduce nitroblue tetrazolium in uremic patients treated conservatively].
NTB reduction test, both spontaneous and stimulated with E. coli endotoxin, was performed in peripheral blood granulocytes of 40 individuals of both sexes aged between 18 and 64 years treated conservatively at the nephrologic outpatient clinic. Serum creatinine, urea and uric acid were assayed at the same time. A control group included 40 healthy individuals of both sexes aged between 20 and 56 years. Statistically significant increase in spontaneous reduction of NTB was achieved in the group of the uremic patients in comparison with the control group. Moderately positive correlation between creatinine level and percentage of NTB-positive cells in the spontaneous test was shown. Possibility of granulocyte stimulation by uremic toxins is being considered.
Golec
K
K
Golec
I
I
Wołosowicz
N
N
D000328:Adult; D003404:Creatinine / Q000097:blood; D005260:Female; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009580:Nitroblue Tetrazolium; D010084:Oxidation-Reduction; D013778:Tetrazolium Salts; D014511:Uremia / Q000097:blood* / Q000628:therapy
D013778:Tetrazolium Salts; D009580:Nitroblue Tetrazolium; D003404:Creatinine
Zdolność granulocytów do redukcji błekitu nitrotetrazoliowego u chorych z mocznica leczonych zachowawczo.