title: Pharmacotherapeutic interventions for cocaine abuse. Matching patients to treatments.
abstract: Cocaine abuse treatment has begun to use a variety of adjunctive pharmacotherapies. These medications have been used for both acute crash symptoms and long-term prevention of relapse. A phasic model of recovery was integrated with a patient typology to formulate guidelines for using these rapidly evolving pharmacotherapies. The phases are crash, with-drawal, and extinction, and the patient typology includes psychiatric vulnerability and severity of cocaine abuse as contributors to the neuroadaptation that requires pharmacological amelioration. These guidelines address five issues: whom to treat, when to treat, what treatments are available, where to initiate and maintain treatment, and how to match patients to treatment options.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: T R
authors.initials: TR
authors.lastname: Kosten
mesh_terms: D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy; D002985:Clinical Protocols; D003042:Cocaine; D005260:Female; D006801:Humans; D019964:Mood Disorders / Q000150:complications / Q000188:drug therapy; D011247:Pregnancy; D011248:Pregnancy Complications; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000150:complications / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D003042:Cocaine