[New radiopharmaceuticals for oncologic diagnosis and therapy: developments in radioimmunoscintigraphy and radioimmunotherapy].
131I labeled monoclonal antibodies are at a disadvantage for radioimmunoscintigraphy due to the in-vivo cleavage of radioiodine by deiodases. Alternative labeling with 99mTc was not very successful because of the lack of suitable ligands for stable technetium complexes. New developments in this field will be presented using stable 99mTc-N2S2 complexes. Some comments on radioimmunotherapy have also been added.
Eisenhut
M
M
Klinikum der Universität Heidelberg, Radiologische Klinik, Abt. Nuklearmedizin.
Brandau
W
W
Reinel
U
U
Kimmig
B
B
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology* / Q000532:radiotherapy; D011868:Radioisotopes / Q000627:therapeutic use; D011877:Radionuclide Imaging
D000911:Antibodies, Monoclonal; D011868:Radioisotopes
Neue Radiopharmaka für die onkologische Diagnostik und Therapie: Entwicklungen bei der Radioimmunszintigraphie und Radioimmuntherapie.