title: Immunoglobulin abnormalities in renal transplant recipients.
abstract: Five renal transplant recipients were observed to have recurrent infections in association with low serum immunoglobulin levels. They have benefited from parenteral gamma globulin therapy. Following this observation, 110 renal transplant recipients were assessed; 46% had abnormal serum immunoglobulins with 4 patients identified as having monoclonal gammopathies, 8 polyclonal gammopathies, and 39 low levels of 1 or more immunoglobulins. Those with abnormal serum immunoglobulins had been immunosuppressed longer, but maintenance immunosuppression dosage was not different from those with normal immunoglobulins. Respiratory tract infection and skin cancer were more frequent in those with low immunoglobulin levels.
authors.affiliation: Department of Renal Medicine, Royal North Shore Hospital, St. Leonards, New South Wales, Australia.
authors.forename: C A
authors.initials: CA
authors.lastname: Pollock
authors.forename: J F
authors.initials: JF
authors.lastname: Mahony
authors.forename: L S
authors.initials: LS
authors.lastname: Ibels
authors.forename: R J
authors.initials: RJ
authors.lastname: Caterson
authors.forename: D A
authors.initials: DA
authors.lastname: Waugh
authors.forename: J V
authors.initials: JV
authors.lastname: Wells
authors.forename: A G
authors.initials: AG
authors.lastname: Sheil
mesh_terms: D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000097:blood / Q000209:etiology*; D000368:Aged; D001424:Bacterial Infections / Q000209:etiology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000097:blood / Q000209:etiology*; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology; D012878:Skin Neoplasms / Q000209:etiology
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M