title: [Effect of coronary arterial occlusion on prostacyclin biosynthesis in dogs of various ages].
abstract: In acute experiments in animals of different age, local myocardial ischemia was stimulated, and the pattern of change in prostacyclin biosynthesis by segments of ischemized and normal coronary arteries was studied. Prostacyclin biosynthesis by coronary arterial segments was much more intensive in young animals, as compared to adult ones. Ischemized arterial segments of pups were also shown to produce a much smaller quantity of prostacyclin, as compared to control animals and to adult levels. The demonstrated findings may be making an important pathogenetic contribution to ischemic heart damage.
authors.forename: G F
authors.initials: GF
authors.lastname: Zadkova
authors.forename: I E
authors.initials: IE
authors.lastname: Smirnov
authors.forename: Kh M
authors.initials: KhM
authors.lastname: Markov
mesh_terms: D000367:Age Factors; D000818:Animals; D001158:Arteries / Q000378:metabolism / Q000601:surgery; D003327:Coronary Disease / Q000209:etiology / Q000378:metabolism*; D003331:Coronary Vessels / Q000378:metabolism* / Q000601:surgery; D004195:Disease Models, Animal; D004285:Dogs; D011464:Epoprostenol / Q000096:biosynthesis*; D008026:Ligation
chemical_list: D011464:Epoprostenol
vernacular_title: Vliianie okkliuzii koronarnoĭ arterii na biosintez v neĭ prostatsiklina u sobak raznogo vozrasta.