Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected].
Clinical and pathological associations with molecular genetic alterations were studied in colorectal carcinomas from 83 patients. Fractional allelic loss, a measure of allelic deletions throughout the genome, and allelic deletions of specific chromosomal arms (the short arm of 17 and long arm of 18) each provided independent prognostic information by multivariate analysis when considered individually with Dukes' classification. Distant metastasis was significantly associated with high fractional allelic loss and with deletions of 17p and 18q. Mutations of ras proto-oncogenes and deletions of 5q had no prognostic importance. Statistically significant associations were also found between allelic losses and a family history of cancer, left-sided tumor location, and absence of extracellular tumor mucin. Allelic deletion analysis thus identified subsets of colorectal carcinoma with increased predilection for distant metastasis and cancer-related death. Further studies may define a subset of genetic alterations that can be used clinically to help assess prognosis.
Kern
S E
SE
Department of Pathology, Johns Hopkins Medical Institution, Baltimore, Md 21205.
Fearon
E R
ER
Tersmette
K W
KW
Enterline
J P
JP
Leppert
M
M
Nakamura
Y
Y
White
R
R
Vogelstein
B
B
Hamilton
S R
SR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000235:genetics* / Q000401:mortality / Q000556:secondary; D002872:Chromosome Deletion; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality; D015342:DNA Probes; D005260:Female; D005500:Follow-Up Studies; D011905:Genes, ras; D006801:Humans; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000096:biosynthesis; D011379:Prognosis
D015342:DNA Probes; D009077:Mucins