title: Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.
abstract: The malaria parasite Plasmodium falciparum contains at least two genes related to the mammalian multiple drug resistance genes, and at least one of the P. falciparum genes is expressed at a higher level and is present in higher copy number in a strain that is resistant to multiple drugs than in a strain that is sensitive to the drugs.
authors.affiliation: Department of Tropical Public Health Harvard School of Public Health, Boston, MA 02115.
authors.forename: C M
authors.initials: CM
authors.lastname: Wilson
authors.forename: A E
authors.initials: AE
authors.lastname: Serrano
authors.forename: A
authors.initials: A
authors.lastname: Wasley
authors.forename: M P
authors.initials: MP
authors.lastname: Bogenschutz
authors.forename: A H
authors.initials: AH
authors.lastname: Shankar
authors.forename: D F
authors.initials: DF
authors.lastname: Wirth
mesh_terms: D018528:ATP-Binding Cassette Transporters; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004351:Drug Resistance / Q000235:genetics; D005784:Gene Amplification; D007447:Invertebrate Hormones / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D010963:Plasmodium falciparum / Q000235:genetics*; D015800:Protozoan Proteins; D012689:Sequence Homology, Nucleic Acid
chemical_list: D018528:ATP-Binding Cassette Transporters; D007447:Invertebrate Hormones; D015800:Protozoan Proteins; C059987:mdr gene protein, Plasmodium