The effect of exogenous human ras and myc oncogenes in morphological differentiation of the rat pheochromocytoma PC12 cells.
An electroporation technique was employed to study the effect of oncogenes H-ras and c-myc after their short-term expression in the rat pheochromocytoma PC12 cells. It was found that within 6 days after electroporation the mutant T24 H-ras 1 gene induced differentiation of PC12 cells whereas the c-myc blocked NGF-induced differentiation. The induction of differentiation by the T24 H-ras gene may suggest a physiological role of the ras gene in cell differentiation as well as in cell proliferation.
Spandidos
D A
DA
Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland, U.K.
D000310:Adrenal Gland Neoplasms; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D016274:Oncogene Protein p55(v-myc); D009857:Oncogenes; D010673:Pheochromocytoma; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D016283:Proto-Oncogene Proteins p21(ras); D051381:Rats; D012191:Retroviridae Proteins / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism
D016274:Oncogene Protein p55(v-myc); D011518:Proto-Oncogene Proteins; D012191:Retroviridae Proteins; D016283:Proto-Oncogene Proteins p21(ras)