Blood flow in the normal human retina.
The laser Doppler technique was used to measure the blood flow rate in 41 major vessels in ten eyes of healthy volunteer subjects. The specific relationship between blood flow rate, F, and vessel diameter, D, was determined for both retinal arteries and retinal veins. On average, F increased with increasing D at a power of 4.1, consistent with the presence of Poiseuille flow. In six eyes of six subjects, measurements on individual vessels were combined to yield the total retinal blood flow rate. The mean and standard deviation of the total retinal blood flow was 80 +/- 12 microliter/min. The blood flow rate per unit mass of retinal tissue was calculated and found to be in good agreement with that reported for macaque monkeys. Blood flow to the temporal side of the retina was approximately three times larger than to the nasal side. There was no significant difference between blood flow to the superior and the inferior retina.
Feke
G T
GT
Eye Research Institute, Retina Foundation, Boston, Massachusetts 02114.
Tagawa
H
H
Deupree
D M
DM
Goger
D G
DG
Sebag
J
J
Weiter
J J
JJ
D000328:Adult; D000465:Algorithms; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D007834:Lasers; D008297:Male; D012039:Regional Blood Flow; D012171:Retinal Vessels / Q000033:anatomy & histology / Q000502:physiology*; D014463:Ultrasonography