In vivo method for the assessment of platelet accumulation.
Platelets labeled with 111Indium have been injected intravenously into anesthetised guinea pigs, and intrathoracic content of 111Indium-labeled platelets has been monitored continuously using a microcomputer-based system (AIMSplus). Dose-effect relationships have been described for ADP, collagen, and PAF, and effects of drugs upon selected responses illustrate the potential of this test system for routine in vivo screening of agents that may inhibit aggregation of platelets.
Smith
D
D
Preclinical Research and Development, Sandoz AG, Basel, Switzerland.
Sanjar
S
S
Herd
C
C
Morley
J
J
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D003094:Collagen / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004912:Erythrocytes / Q000502:physiology; D005340:Fibrinogen / Q000378:metabolism; D006168:Guinea Pigs; D007205:Indium Radioisotopes; D008297:Male; D008838:Microcomputers; D008991:Monitoring, Physiologic / Q000379:methods; D010972:Platelet Activating Factor / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D011865:Radioisotope Dilution Technique
D007205:Indium Radioisotopes; D010972:Platelet Activating Factor; D000244:Adenosine Diphosphate; D005340:Fibrinogen; D003094:Collagen