Two nuclearly inherited loci conferring increased diuron resistance to NADH oxidase in Saccharomyces cerevisiae.
In Saccharomyces cerevisiae, diuron blocks the respiration pathway at the level of the bc1 complex. Nuclear diuron-resistant mutations which confer in vitro resistance to mitochondrial NADH oxidase have been identified. Five mutations were found to be clustered at two distinct nuclear loci DIU3 and DIU4. The distance between the two loci was estimated to be about 36.7 cM. These loci do not appear to be centromere-linked and did not show a linkage to any of the genes coding for bc1 complex subunits. DIU3 and DIU4 loci might, therefore code for other components of the respiratory chain.
Meunier
B
B
Université Catholique de Louvain, Laboratoire de Génétique Microbienne, Louvain-la-Neuve, Belgium.
Colson
A M
AM
D000483:Alleles; D002467:Cell Nucleus; D002874:Chromosome Mapping; D004237:Diuron / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005800:Genes, Fungal; D008040:Genetic Linkage; D008928:Mitochondria / Q000201:enzymology; D009097:Multienzyme Complexes / Q000378:metabolism*; D009154:Mutation; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*
D009097:Multienzyme Complexes; D004237:Diuron; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases