title: Inotropic effects of endothelin in ferret ventricular myocardium.
abstract: The characteristics of the inotropic response to endothelin were studied in isolated ferret papillary muscle preparations. Endothelin (0.1-10 nM) induced concentration-dependent positive inotropic effects. At 10 nM, isometric tension increased by 17%, maximum rate of tension development by 18%, maximum velocity of unloaded shortening by 23% and peak isotonic shortening by 11%. Time to peak isometric tension and half isometric relaxation time were unaltered by endothelin. This pattern of change is similar to that of elevating extracellular calcium concentration.
authors.affiliation: Department of Cardiology, University of Wales College of Medicine, Heath Park, Cardiff, U.K.
authors.forename: A M
authors.initials: AM
authors.lastname: Shah
authors.forename: M J
authors.initials: MJ
authors.lastname: Lewis
authors.forename: A H
authors.initials: AH
authors.lastname: Henderson
mesh_terms: D000818:Animals; D002335:Carnivora / Q000502:physiology*; D016232:Endothelins; D005289:Ferrets / Q000502:physiology*; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology*
chemical_list: D016232:Endothelins; D010455:Peptides