[Pulmonary fibrosis].
Pneumosclerosis (P) is abundant lung synthesis of connective fibers and basic substance by fibroblasts, myofibroblasts, leiomyocytes. The synthesis is increased in lymphoplethora or infiltration by macrophages. T lymphocytes that control fibrillogenesis. One should single out Type I P in the areas of inflammation, which frequently reflects the specificity of the process, and Type II P outside the inflammatory areas, which is non-specific and may develop in cardiac abnormalities. Type Ia P may develop without suppuration in the areas of macrophage or lymphocyte infiltration in the reticular stroma of the lung which is rich in capillaries (the image of alveoli is distinguishable). Type Ib P characterizes the processes accompanied by suppuration when the granulation tissue completely eliminates the image of the lung due to its budding capillaries. Type IIa P develops in the fibrotic stroma deprived of capillaries and, therefore, not subjected to inflammatory infiltration. The function of fibroblasts is increased by lymphoplethora, in atelectases in particular, when pneumocirrhosis develops. Type IIb occurs in the hypertrophic leiomyocytes of the vessels and bronchi. While comparing the topography of P, cellular composition and change pattern of the elastica, one may gain an insight into the etiology of P to some extent.
Esipov
I K
IK
D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D011658:Pulmonary Fibrosis / Q000473:pathology*
Pnevmoskleroz.