Hormonal and glycaemic responses to serial meals in newly diagnosed non insulin dependent diabetic patients.
The hormonal and glycaemic responses to serial test meals have been well documented in normal subjects and in patients with insulin dependent diabetes. There is less information in patients with non-insulin dependent diabetes. We studied 39 newly diagnosed previously untreated non-insulin dependent diabetics. Each patient received four identical test meals over a 24 hour period and their plasma glucose and insulin levels were determined at frequent intervals throughout the study period. The results show that all the non-insulin dependent patients at diagnosis had large post-prandial glucose excursions, and that the post-prandial rise in insulin was delayed. The study also demonstrates that glucose and insulin profiles are dependent on the degree of obesity of the patient. Patients with non-insulin dependent diabetes have a greater degree of glucose intolerance in the morning in contrast to normal subjects whose glucose tolerance is best in the morning.
Owens
D R
DR
Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff, U.K.
Dolben
J
J
Jones
I R
IR
Birtwell
J
J
Luzio
S D
SD
D001786:Blood Glucose / Q000378:metabolism*; D002940:Circadian Rhythm; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D004435:Eating; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D001786:Blood Glucose; D007328:Insulin