title: Effects of phenylbutazone on glucose tolerance and on secretion of insulin in healthy geldings.
abstract: The effect of phenylbutazone (4.4 mg/kg of body weight, IV, q 24 h, for 5 days) on glucose tolerance and on secretion of insulin in 6 healthy geldings was determined. Phenylbutazone significantly lowered fasting concentrations of glucose in plasma but did not significantly change the concentration of insulin in serum. There was no significant effect of phenylbutazone on glucose tolerance, on secretion of insulin, or on the area under the insulin/glucose ratio vs time curve in healthy geldings, as determined by paired t test analysis.
authors.affiliation: Department of Large Animal Medicine and Surgery, Texas Veterinary Medical Center, College Station 77843.
authors.forename: S C
authors.initials: SC
authors.lastname: Zicker
authors.forename: G W
authors.initials: GW
authors.lastname: Brumbaugh
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D005951:Glucose Tolerance Test / Q000662:veterinary; D006736:Horses / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010653:Phenylbutazone