Reversibility of biochemical and cytological alterations in broncho-alveolar lavagate upon cessation of dust exposure.
The objectives of the present study were: 1. To investigate the nature and time course of the biochemical and cytological changes following acute and subchronic exposure intervals. 2. To investigate the dependence of the response upon the pulmonary burden of the test material. Alveolar clearance measurements were performed in parallel and are presented in a separate poster (1).
Creutzenberg
O
O
Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, FRG.
Muhle
H
H
Bellmann
B
B
Kilpper
R
R
Mermelstein
R
R
Morrow
P
P
D000818:Animals; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis / Q000166:cytology*; D004391:Dust / Q000009:adverse effects*; D004781:Environmental Exposure; D005260:Female; D008657:Metabolic Clearance Rate; D008689:Methacrylates / Q000493:pharmacokinetics; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
D004391:Dust; D008689:Methacrylates