title: Radiation-induced intracranial malignant gliomas.
abstract: The authors present seven cases of malignant gliomas that occurred after radiation therapy administered for diseases different from the subsequent glial tumor. Included among these seven are three patients who were treated with interstitial brachytherapy. Previously reported cases of radiation-induced glioma are reviewed and analyzed for common characteristics. Children receiving central nervous system irradiation appear particularly susceptible to induction of malignant gliomas by radiation. Interstitial brachytherapy may be used successfully instead of external beam radiotherapy in previously irradiated, tumor-free brain, and thus may reduce the risk of radiation necrosis.
authors.affiliation: Department of Neurosurgery, Indiana University Medical Center, Indianapolis.
authors.forename: S
authors.initials: S
authors.lastname: Shapiro
authors.forename: J
authors.initials: J
authors.lastname: Mealey
authors.forename: C
authors.initials: C
authors.lastname: Sartorius
mesh_terms: D000328:Adult; D001918:Brachytherapy; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000532:radiotherapy; D002648:Child; D003390:Cranial Nerve Neoplasms / Q000532:radiotherapy; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000532:radiotherapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000532:radiotherapy; D011832:Radiation Injuries; D014057:Tomography, X-Ray Computed