A dynamic model of angiotensin II infusion experiments.
Applications of control theory in studies of biological system dynamics have come to be called compartmental modelling. A second order, nonlinear, compartmental model is developed which describes the dynamics of the hormone angiotensin II (AII) and arterial blood pressure (BP) during AII infusion experiments. The model is partially identified using dose response data for constant infusion rates between 0.01 and 0.10 microgram/kg/min over a period of several minutes. This study represents a first step in understanding the dynamics of regulation of arterial blood pressure by the renin-angiotensin system. AII is a vasoconstrictor and is known to participate in the natural regulation of BP. AII is also believed to be an agent in the development of hypertension and atherosclerosis. The model is used to identify causal mechanisms which are consistent both with the established correlation between plasma AII concentration and arterial BP and with current physiological knowledge. The study demonstrates how a simple state variable model can be used to provide guidance concerning the design of future infusion experiments.
White
K P
KP
Department of Systems Engineering, University of Virginia, Charlottesville 22901.
Radke-Sharpe
N F
NF
Kaiser
D L
DL
Owens
G K
GK
D000804:Angiotensin II / Q000008:administration & dosage* / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007262:Infusions, Intravenous; D008954:Models, Biological; D008955:Models, Cardiovascular; D011945:Receptors, Angiotensin / Q000378:metabolism; D012084:Renin-Angiotensin System
D011945:Receptors, Angiotensin; D000804:Angiotensin II