title: Transplantable mouse 16/c mammary adenocarcinoma as a model in experimental cancer therapy. II. Modification of tumor-host interactions by therapeutic procedures.
abstract: The influence of therapeutic procedures on tumor--host interactions was analysed using 16/c mouse mammary adenocarcinoma model system. After partial removal of tumor burden the growth enhancement of remnant tumor mass was observed. Pretreatment of the host either with cyclophosphmide or X-rays resulted in enhancement of experimental metastasis formation. Unexpectedly, such a procedure caused the growth delay of the primary subcutaneous tumor. The possible mechanisms of observed phenomena are discussed.
authors.affiliation: Department of Tumor Immunology, Polish Academy Sciences, Wroclaw.
authors.forename: J
authors.initials: J
authors.lastname: Rak
authors.forename: L
authors.initials: L
authors.lastname: Strzadała
authors.forename: H
authors.initials: H
authors.lastname: Kuśnierczyk
authors.forename: C
authors.initials: C
authors.lastname: Radzikowski
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000556:secondary; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000532:radiotherapy; D051379:Mice; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation
chemical_list: D000970:Antineoplastic Agents; D003520:Cyclophosphamide