title: [Neonatal lupus erythematosus].
abstract: The neonatal lupus erythematosus syndrome, first described by McCuistion and Schoch in 1954, is associated with characteristic skin lesions and congenital heart block in the new-born, and the presence of Ro-(SSA), La-(SSB), or RNP antibodies in mothers and infants. A transplacental transference of maternal autoantibodies is discussed as possible pathophysiologic mechanism in neonatal lupus. The symptoms, the onset, and recently published pathogenetic concepts are reviewed.
authors.affiliation: I. Medizinische Klinik, Universität Mainz.
authors.forename: W J
authors.initials: WJ
authors.lastname: Mayet
authors.forename: E
authors.initials: E
authors.lastname: Hermann
authors.forename: M
authors.initials: M
authors.lastname: Bachmann
authors.forename: T
authors.initials: T
authors.lastname: Poralla
authors.forename: K H
authors.initials: KH
authors.lastname: Meyer zum Büschenfelde
mesh_terms: D000974:Antibodies, Antinuclear / Q000235:genetics / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D000974:Antibodies, Antinuclear; D006680:HLA Antigens; C035356:SS-A antibodies; C035357:SS-B antibodies
vernacular_title: Neonataler Lupus erythematodes.