A comparison of transcutaneous PO2 in patients sedated with diazepam-fentanyl or midazolam-fentanyl.
Fifty oral and maxillofacial surgery patients undergoing outpatient surgical removal of third molars under intravenous conscious sedation comprised the study group. All patients received 1 microgram/kg of fentanyl prior to receiving either diazepam or midazolam. The results show no statistically significant differences in blood pressure or pulse over time between the two groups, nor was there a statistically significant difference between the transcutaneous PO2 responses of the groups. However, a statistically significant time effect as well as a group by time interaction was present. Both groups show respiratory depression at the 8- and 10-minute time intervals. The use of supplemental oxygen and monitoring of respiration is recommended with the use of these drug combinations.
Sutley
S H
SH
Kraut
R A
RA
D001785:Blood Gas Monitoring, Transcutaneous; D003975:Diazepam / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005283:Fentanyl / Q000627:therapeutic use*; D006801:Humans; D008874:Midazolam / Q000627:therapeutic use*
D003975:Diazepam; D008874:Midazolam; D005283:Fentanyl