[Experimental studies of anticancer drugs more appropriate for high-dose chemotherapy in bone marrow transplantation and their administration methods].
We studied in rats the anticancer drugs which can utilize more the advantage of bone marrow transplantation (BMT) and on their administration ways in high-dose chemotherapy (HC) with BMT. Among six anticancer drugs tested (ACNU, ADR, CY, MMC, VDS, VP-16), a beneficial effect of BMT was observed only with CY and ACNU. In order to increase the beneficial effect of BMT observed with CY and ACNU, the methods of administering these two drugs were carefully designed, and better survival curves were obtained in the following administration groups: 1) (CY 200 mg/kg, days 0 & 1) + BMT greater than (CY 400 mg/kg, day 0) + BMT, (ACNU 20 mg/kg, day 0 & 1) + BMT greater than (ACNU 40 mg/kg, day 0) + BMT. 2) (CY 200 mg/kg + ACNU 20 mg/kg, day 0) + BMT greater than (CY 400 mg/kg or ACNU 40 mg/kg, day 0) + BMT. 3) (CY 200 mg/kg, day 0) + (ACNU 20 mg/kg, day 1) + BMT greater than (ACNU 20 mg/kg, day 0) + (CY 200 mg/kg, day 1) + BMT. Further studies on anticancer drugs more appropriate for HC-BMT and on their administration methods were considered to be very necessary.
Mizushima
Y
Y
First Department of Internal Medicine, Toyama Medical and Pharmaceutical University.
Morikage
T
T
Sasaki
K
K
Yano
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000633:toxicity; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity; D004334:Drug Administration Schedule; D005260:Female; D015376:Nimustine / Q000008:administration & dosage / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D015376:Nimustine; D003520:Cyclophosphamide