title: The direct observation of arteriolar constriction induced by endothelin in vivo.
abstract: The effect of endothelin on the microvasculature of the hamster cheek pouch was observed directly using intravital microscopy. Endothelin caused a dose-dependent arteriolar constriction without affecting adjacent venules. Endothelin was less potent than vasopressin, but responses to endothelin were longer lasting (48.9 +/- 11.1% reduction in arteriolar diameter was still observed 30 min after topical application of 3 pmol endothelin). The results demonstrate that endothelin induces a prolonged increase in local arteriolar tone after a single application in vivo.
authors.affiliation: Section of Vascular Biology, MRC Clinical Research Centre, Harrow, Middlesex, U.K.
authors.forename: S D
authors.initials: SD
authors.lastname: Brain
mesh_terms: D000818:Animals; D001160:Arterioles / Q000187:drug effects; D006224:Cricetinae; D016232:Endothelins; D066298:In Vitro Techniques; D008297:Male; D008647:Mesocricetus; D008833:Microcirculation / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D011650:Pulmonary Alveoli / Q000187:drug effects*; D014667:Vasopressins / Q000494:pharmacology
chemical_list: D016232:Endothelins; D010455:Peptides; D014667:Vasopressins