Erythrocyte membrane acetylcholinesterase in type 1 (insulin-dependent) diabetes mellitus.
1. The erythrocyte membrane acetylcholinesterase activity is significantly (P less than 0.001) decreased in insulin-dependent diabetes mellitus. 2. The activity is negatively correlated (r = -0.97) with the fasting blood glucose level. 3. Insulin treatment restores the activity to normal. 4. The Km of the enzyme for acetylthiocholine iodide was unchanged; however, the Vmax. was decreased, suggesting a decrease in the number of active enzyme molecules in diabetes.
Suhail
M
M
Department of Biochemistry, University of Allahabad, India.
Rizvi
S I
SI
D000110:Acetylcholinesterase / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000201:enzymology* / Q000628:therapy; D004910:Erythrocyte Membrane / Q000201:enzymology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male
D001786:Blood Glucose; D007328:Insulin; D000110:Acetylcholinesterase