[Heredity and diseases of the organs of the urinary system: results and prospects of research].
The paper deals with current ideas of the role played by heredity in the development of diseases of the urinary system organs (USO). Hereditary nephropathies are divided into groups of disorders associated with chromosome aberrations (0.28 percent), monogen-inherited pathology (13 percent), multifactorial or polygen-inherited pathology (86.72 percent). Hereditary predisposition associated with antigenic determinants of the HIA system, immune, metabolic, histological defects and other factors are implicated in the development of multifactorial diseases. The pathways by which the disease predisposition is realized are nonuniform. There prospect well novel biotechnological approaches, virologic, pharmacogenetic studies aimed at understanding of the role of heredity in the development of USO disorders, at diagnosing borderline illnesses, and at preventing the disease manifestations.
Ignatova
M S
MS
D002648:Child; D002869:Chromosome Aberrations; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007674:Kidney Diseases / Q000235:genetics* / Q000276:immunology; D012106:Research
D006680:HLA Antigens; D007073:Immunoglobulin E
Nasledstvennost' i zabolevaniia organov mochevoĭ sistemy: rezul'taty i perspektivy issledovaniĭ.