title: Nature of renal involvement in the acro-renal-ocular syndrome.
abstract: A 16-year-old female with acro-renal-ocular syndrome complicated by ventricular septal defect is described. Renal biopsy was performed for the first time in this syndrome, and the results suggested that proteinuria and renal dysfunction were caused by chronic pyelonephritis secondary to malrotation of the kidney and anomalous pelves. Chronic renal failure and hypoplasia of the optic papillae were also observed in the patient's mother, suggesting a participation of heredity in the pathogenesis of the syndrome.
authors.affiliation: First Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Naito
authors.forename: H
authors.initials: H
authors.lastname: Kida
authors.forename: H
authors.initials: H
authors.lastname: Yokoyama
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: S
authors.initials: S
authors.lastname: Takeda
authors.forename: D
authors.initials: D
authors.lastname: Uno
authors.forename: N
authors.initials: N
authors.lastname: Hattori
mesh_terms: D000293:Adolescent; D001706:Biopsy; D005121:Extremities / Q000000981:diagnostic imaging; D005128:Eye Diseases / Q000150:complications*; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D017880:Limb Deformities, Congenital; D008854:Microscopy, Electron; D013577:Syndrome; D014057:Tomography, X-Ray Computed