title: Extrapancreatic gastrinoma with pancreatic islet cell hyperplasia.
abstract: A case of Zollinger-Ellison syndrome was associated with diffuse islet cell hyperplasia of the pancreas and extrapancreatic gastrinoma. At autopsy, the patient, who had well-documented Zollinger-Ellison syndrome, was found to have gastrinoma in parapancreatic lymph nodes with islet cell hyperplasia but no evidence of pancreatic neoplasm. Possible explanations include the production of a trophic factor by the extrapancreatic gastrinoma, leading to islet cell hyperplasia, or metastasis from a microscopic nodule of gastrin cells that, despite having a "hyperplastic" appearance, exhibited malignant potential.
authors.affiliation: Department of Laboratories, Mount Sinai Medical Center, Cleveland, OH 44106.
authors.forename: J
authors.initials: J
authors.lastname: Sawady
authors.forename: G
authors.initials: G
authors.lastname: Mendelsohn
mesh_terms: D000328:Adult; D001344:Autopsy; D005260:Female; D015408:Gastrinoma / Q000150:complications* / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D007515:Islets of Langerhans / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D015043:Zollinger-Ellison Syndrome / Q000150:complications / Q000473:pathology