title: [Wegener's granulomatosis and pregnancy. A case].
abstract: Pregnancy concomitant with Wegener's granulomatosis is extremely rare: so far, only four cases have been published. The authors report a fifth case where the disease appeared during the post-partum period, a situation which has already been noted in two of the published cases. Interruption of a subsequent pregnancy was followed by a flare-up of the disease resulting in the patient's death. This suggests that post-partum and post-abortum are probably instrumental in the onset and deterioration of Wegener's granulomatosis. The two patients previously reported who received immunosuppressants combined with corticosteroids had no flare-up after delivery. It seems permissible to prescribe such a therapeutic combination before and after delivery or abortion, especially since the fear of foetal toxicity from these drugs seems to be exaggerated.
authors.affiliation: Service de médecine interne, CHU La Marsa, Tunisie.
authors.forename: S
authors.initials: S
authors.lastname: M'Rad
authors.forename: M
authors.initials: M
authors.lastname: Moalla
authors.forename: K
authors.initials: K
authors.lastname: Ben Miled
authors.forename: A
authors.initials: A
authors.lastname: Falfoul
authors.forename: M
authors.initials: M
authors.lastname: Grossin
authors.forename: S
authors.initials: S
authors.lastname: Ben Jilani
authors.forename: M
authors.initials: M
authors.lastname: Hamza
authors.forename: M
authors.initials: M
authors.lastname: Ben Dridi
authors.forename: H
authors.initials: H
authors.lastname: Ben Ayed
mesh_terms: D000032:Abortion, Therapeutic; D000328:Adult; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D049590:Postpartum Period; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy
vernacular_title: Granulomatose de Wegener et grossesse. Une observation.