Cytogenetic investigations of the allodermis after intermingled skin grafting.
In most instances intermingled skin transplants done according to the method developed in the PR China are not subject to a generalized rejection. During the healing process there is an integration of the allodermis instead, which eventually becomes covered by outgrowing auto-epidermal cells. To investigate the fate of allogenic cells experiments were done with intermingled skin grafts, using male Wistar rats as recipients and female DA-rats as donors. By studying karyotype analysis of cells growing out from intermingled skin biopsies the presence of viable allogenic cells was demonstrated on days 53 and 111 post-transplantation. It was concluded that the intermingled skin forms a cellular mosaic with different portions of autogenic and allogenic cells.
Kistler
D
D
Department of Burns, Plastic and Reconstructive Surgery, RWTH-Aachen, FR Germany.
Hafemann
B
B
Hettich
R
R
D000818:Animals; D002478:Cells, Cultured; D000078404:Epidermal Cells; D005260:Female; D007621:Karyotyping; D008297:Male; D009030:Mosaicism; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000166:cytology; D016038:Skin Transplantation; D014184:Transplantation, Homologous