title: 1H NMR study of cerebral development in the rat.
abstract: 1H NMR spectroscopy of brain extracts was used to investigate the metabolic changes that take place during development of the neonatal rat brain. Data were obtained over the range 1-21 days. The concentration of N-acetylaspartate rose by a factor of 9 during this period, the most rapid rise occurring after day 9. The total creatine concentration rose from days 1-21, with a large increase between days 1 and 5. Taurine concentration rose until day 5, then fell from days 5-21. The concentration of choline-containing compounds fell during the 21 day period. The results are discussed in relation to brain development and conventional biochemical data. A major conclusion in relation to spectroscopy of children is that interpretation of changes seen in disease will require adequate data from age-matched controls.
authors.affiliation: Department of Physics, Hunterian Institute, Royal College of Surgeons of England, London, UK.
authors.forename: T E
authors.initials: TE
authors.lastname: Bates
authors.forename: S R
authors.initials: SR
authors.lastname: Williams
authors.forename: D G
authors.initials: DG
authors.lastname: Gadian
authors.forename: J D
authors.initials: JD
authors.lastname: Bell
authors.forename: R K
authors.initials: RK
authors.lastname: Small
authors.forename: R A
authors.initials: RA
authors.lastname: Iles
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains