Prostacyclin production by human umbilical vein endothelium in response to serum from patients with systemic sclerosis.
Sera from 29 patients with systemic sclerosis and 30 normal controls were examined for their effect on prostacyclin release by human umbilical vein endothelial cells during periods of response of 15 min and 72 h and for their effect on endothelial growth and 3H-thymidine uptake during a 72-h culture period. In contrast to previous reports, no significant differences were detected between patient and control sera in their effect on endothelial cell prostacyclin release, growth or 3H-thymidine uptake.
Holt
C M
CM
University Department of Medicine, Northern General Hospital, Sheffield.
Moult
J
J
Lindsey
N
N
Hughes
P
P
Greaves
M
M
Rowell
N R
NR
D000328:Adult; D000368:Aged; D002455:Cell Division; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012595:Scleroderma, Systemic / Q000097:blood*; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014471:Umbilical Veins / Q000166:cytology / Q000378:metabolism*
D011464:Epoprostenol; D013936:Thymidine