title: Delayed hemolysis resulting from anti-A1 after liver transplantation.
abstract: The authors report a case of a delayed hemolytic transfusion reaction in a type A2 recipient of a type O liver allograft. An anti-A1 antibody reactive at 37 degrees C in the indirect antiglobulin test was identified both in the patient's serum and in an eluate. Hemolysis secondary to the production of anti-A1 has been reported to be extremely rare. The English-language literature has six cases before 1979. During the 1980s, an additional seven cases were reported; six involved transplantation of a solid organ, and in each such case the donor was type O and the recipient was type A1 or A2. Recommendations regarding transfusion practice in such cases are made. An association among the transplantation of a type O organ to a type A recipient, the use of cyclosporine, and an apparent increase in the occurrence of clinically significant anti-A1 is suggested.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905.
authors.forename: M E
authors.initials: ME
authors.lastname: Brecher
authors.forename: S B
authors.initials: SB
authors.lastname: Moore
authors.forename: R K
authors.initials: RK
authors.lastname: Reisner
authors.forename: J
authors.initials: J
authors.lastname: Rakela
authors.forename: R A
authors.initials: RA
authors.lastname: Krom
mesh_terms: D001323:Autoantibodies / Q000096:biosynthesis / Q000502:physiology*; D005260:Female; D006461:Hemolysis; D006801:Humans; D016031:Liver Transplantation; D008875:Middle Aged; D013997:Time Factors
chemical_list: D001323:Autoantibodies