title: Isozyme polymorphisms maintained by lethal loci in inbred strains of Aedes triseriatus.
abstract: We analyzed the progeny of brother-sister matings of two inbred strains of the treehole mosquito, Aedes triseriatus, at several isozyme loci to determine which factors were maintaining heterozygosity at these loci after prolonged inbreeding. The triseriatus Kramer (TK) lines were polymorphic for the Odh and Hbd loci after 12 generations of full-sib mating, and the triseriatus Vero Beach (TV) lines were polymorphic for the Odh, Hk-4, Pgm, and Hbd loci after 14 generations of full-sib mating. Genetic analysis of 22 TK F13 matings and nine TV F15 matings showed that heterozygosity was enforced by lethal loci to which all the polymorphic isozyme loci were linked. The lethal loci formed a balanced lethal system. We determined the relative positions and map distances of lethals and enzyme loci.
authors.affiliation: Department of Biology, University of Notre Dame, Indiana.
authors.forename: T C
authors.initials: TC
authors.lastname: Matthews
authors.forename: G B
authors.initials: GB
authors.lastname: Craig
mesh_terms: D000330:Aedes / Q000201:enzymology* / Q000235:genetics; D000429:Alcohol Oxidoreductases / Q000235:genetics; D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005804:Genes, Lethal; D008040:Genetic Linkage; D005838:Genotype; D006579:Heterozygote; D007178:Inbreeding; D007527:Isoenzymes / Q000235:genetics*; D008297:Male; D009026:Mortality; D011110:Polymorphism, Genetic
chemical_list: D007527:Isoenzymes; D000429:Alcohol Oxidoreductases; C021902:octanol dehydrogenase