[Methods of treating experimental Neguvon poisoning and a comparison of their effects].
The effect of conventional antidotal therapy of oral intoxication due to organophosphorus insecticide Neguvon in male mice is compared to the effect of peritoneal dialysis. As a dialysate, the combination of ACHE reactivator with atropine, distilled water and ACHE preparation has been used. In order to evaluate treatment results, the clinical course of intoxication and the increase of blood ACHE activity inhibited with perorally Neguvon were investigated. The highest increase in activity of inhibited blood ACHE has been stated by the peritoneal dialysis with ACHE preparation. Furthermore, the effects of two dialysates were compared. The first one consisted in ACHE reactivator with atropine, and the second one in ACHE preparation, respectively. The ACHE containing dialysate showed better therapeutical results. The mentioned acetylcholinesterase is stated to be inhibited through the treatment with 50% of Neguvon dosage applied to the experimental animals. Thus the actual dose of Neguvon inducing proper intoxication was reduced to its half amount.
Kassa
J
J
Vojenská lékarská akademie.
Stefánik
M
M
D000110:Acetylcholinesterase / Q000008:administration & dosage / Q000097:blood; D000818:Animals; D001285:Atropine / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004793:Enzyme Reactivators / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D051379:Mice; D010530:Peritoneal Dialysis; D051381:Rats; D014236:Trichlorfon / Q000506:poisoning*
D004793:Enzyme Reactivators; D001285:Atropine; D014236:Trichlorfon; D000110:Acetylcholinesterase
Způsoby lécení experimentální otravy Neguvonem a srovnání jejich úcinku.