Acute myelogenous leukemia in first relapse treated with two consecutive autologous bone marrow transplantations: a pilot study.
The feasibility and the antileukemic activity of a double sequential autograft has been evaluated in 3 patients affected by AML in first hematological relapse. Bone marrow collection and cryopreservation was performed twice: during first complete remission (CR) and during second CR. At the time of relapse patients underwent first ABMT with BAVC preparative regimen achieving a second CR without any remarkable complications. After 4, 5 and 4 months respectively a second ABMT was performed with a different preparative regimen, consisting of cyclophosphamide and fractionated total body irradiation (Cy + F-TBI). A delay in platelet recovery was observed after the second procedure as compared to the first, while neutrophils recovery was comparable. 1 patient died in CR (on day +91 after second ABMT) of interstitial pneumonitis. 2 patients are alive and well without evidence of disease after 46 and 53 months of unmaintained second CR. This experience shows the high antileukemic potential of treatment with a double sequential autograft; 2 relapsed patients in fact are long-term survivors with a second CR longer than the first.
Meloni
G
G
Institute of Hematology, University La Sapienza, Rome, Italy.
De Fabritis
P
P
Pulsoni
A
A
Sandrelli
A
A
Simone
F
F
Mandelli
F
F
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000628:therapy*; D015479:Leukemia, Myelomonocytic, Acute / Q000097:blood / Q000628:therapy*; D007958:Leukocyte Count; D009364:Neoplasm Recurrence, Local; D009504:Neutrophils; D010865:Pilot Projects; D010976:Platelet Count; D012074:Remission Induction; D013997:Time Factors; D014182:Transplantation, Autologous