title: Use of a long-acting cephalosporin (ceftriaxone) for antimicrobial prophylaxis in abdominal and biliary surgery.
abstract: Present data available on ceftriaxone (Rocephin) dealing with microbiology, pharmacokinetics (long half-life, tissue penetration ability, tissue concentration present during vulnerable period, etc.), results of clinical trials, and world-wide experience seem to be in favor of ceftriaxone as the antimicrobial of choice for single-dose antibiotic prophylaxis in abdominal and biliary surgery. Single-dose surgical prophylaxis is cost-effective, has a low rate of adverse drug events, and so far does not increase danger of resistance.
authors.affiliation: F. Hoffmann-La Roche & Co. Limited, Basle, Switzerland.
authors.forename: K
authors.initials: K
authors.lastname: Hell
mesh_terms: D000005:Abdomen / Q000601:surgery*; D001424:Bacterial Infections / Q000517:prevention & control*; D001662:Biliary Tract Surgical Procedures; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication
chemical_list: D002443:Ceftriaxone