title: [Fatal cerebral aspergillosis in acute megakaryoblastic leukemia].
abstract: A 13 year-old girl was diagnosed as having acute megakaryoblastic leukemia. A serious infectious syndrome appeared during the chemotherapy, not improved by broad spectrum antibiotic therapy. A pulmonary aspergillosis was diagnosed one month later by a second bronchoalveolar lavage. A treatment with Itraconazole, a new antifungal triazole, was started. Despite this treatment, the child died after 3 days. Death was due to multiple aspergillus abscesses disseminated in the brain leading to coma and transtentorial herniation. Autopsy confirmed the cerebral aspergillus abscesses and showed also the dramatic dissemination of aspergillosis in the body. Diagnosis and treatment to aspergillosis in immunosuppressed patients should be made early to improve prognosis.
authors.affiliation: Service de Réanimation médicale (Unité Pédiatrique), CHRU, Caen.
authors.forename: C
authors.initials: C
authors.lastname: Perrin
authors.forename: P
authors.initials: P
authors.lastname: Boutard
authors.forename: O
authors.initials: O
authors.lastname: Reman
authors.forename: C
authors.initials: C
authors.lastname: Lecacheux
authors.forename: F
authors.initials: F
authors.lastname: Chapon
mesh_terms: D000293:Adolescent; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000209:etiology*; D001232:Aspergillus fumigatus; D001922:Brain Abscess / Q000209:etiology*; D005260:Female; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000150:complications*; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging; D011859:Radiography; D012307:Risk Factors
vernacular_title: Aspergillose cérébrale mortelle lors d'une leucémie aiguë à mégacaryoblastes.