Dosimetric equivalence of tar deposition in rodents and man.
It has proved very difficult to produce cancer in laboratory animals following the inhalation of tar from cigarette smoke. Amongst other factors, this may be due to the dose that animals get in comparison to humans. Data reported here suggest that the average dose to the bronchial region of the lung, estimated using radiotracer techniques, may be a factor of 4 lower. The local dose to the carinal is also discussed; this may be lower still.
Pritchard
J N
JN
Environmental and Medical Sciences Division, UKAEA, Oxon, UK.
McAughey
J J
JJ
Black
A
A
D000280:Administration, Inhalation; D000818:Animals; D006801:Humans; D008168:Lung / Q000032:analysis; D008297:Male; D051379:Mice; D051381:Rats; D012907:Smoking / Q000009:adverse effects; D013638:Tars / Q000008:administration & dosage / Q000032:analysis*
D013638:Tars