Age-related changes in brush border enzymes under different dietary conditions.
We examined the age-related changes of renal brush border enzymes of male Donryu rats under different dietary conditions. High protein diet (51% casein) markedly decreased the activity of renal leucine aminopeptidase as compared with low protein diet (8% casein). No significant difference, however, was observed in the activity of renal maltase between high and low protein diets. Alkaline phosphatase activity from young adult (3-month-old) rats in the high protein diet group was significantly lower than that in the low protein diet groups. From these results, it is inferred that dietary conditions affect the age-related alteration of renal brush border enzymes. Together with the previous results, it is suggested that proteins of renal brush borders are altered differently during the aging process.
Nakano
M
M
Institute for Medical Science of Aging, Aichi Medical University, Japan.
Tauchi
H
H
Katoh
H
H
Kondoh
H
H
D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D004032:Diet; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000494:pharmacology; D007668:Kidney / Q000201:enzymology* / Q000648:ultrastructure; D007931:Leucyl Aminopeptidase / Q000378:metabolism*; D008297:Male; D008871:Microvilli / Q000201:enzymology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D000520:alpha-Glucosidases / Q000378:metabolism*
D004044:Dietary Proteins; D000469:Alkaline Phosphatase; D000520:alpha-Glucosidases; D007931:Leucyl Aminopeptidase