1H-pyrrolo[2,3-f]quinoline and isoquinoline derivatives: synthesis and antiproliferative activity.
Fischer indol synthesis is reported for the preparation of some 2-substituted 1H-pyrrolo[2,3-f]quinoline and isoquinoline derivatives having a structural correlation with naturally occurring compound ellipticine. The prepared compounds proved capable of forming in vitro molecular complexes with native double-stranded DNA by intercalation between two base pairs and showed a relatively good activity in inhibiting the DNA synthesis in Ehrlich ascites tumor cells.
Ferlin
M G
MG
Dipartimento di Scienze Farmaceutiche dell'Università, Padova, Italy.
Chiarelotto
G
G
Basadonna
O
O
Gia
O
O
Mobilio
S
S
Baccichetti
F
F
Carlassare
F
F
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D002942:Circular Dichroism; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013050:Spectrometry, Fluorescence
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D007546:Isoquinolines; D011758:Pyrroles; D011804:Quinolines