title: Half-body radiotherapy in the treatment of canine lymphoma.
abstract: In a Phase I-II study, half-body radiotherapy was used to treat 14 dogs with multicentric lymphoma. Using this technique, a radiation dose of 7 Gray (Gy) was delivered to one half of the body in a single exposure. The other half of the body was treated approximately 28 days later. Of 14 treated dogs, 11 (79%) had a measurable decrease in tumor size. Five dogs achieved a complete or partial remission with a mean duration of 102 and 54 days, respectively. In predicting response to therapy, poor prognostic factors included large tumor burdens, advanced disease stage, and chemotherapy-resistant tumors. Side effects of treatment were divided chronologically into acute (radiation sickness, tumor lysis), subacute (bone marrow suppression), and chronic (radiation pneumonitis, lymphoma-cell leukemia) syndromes. Complications were more severe in tumor-bearing dogs when compared with healthy control animals. Dogs with small tumor burdens and minimal internal disease had fewer complications compared with those with more advanced disease.
authors.affiliation: Department of Clinical Studies, Ontario Veterinary College, Guelph, Canada.
authors.forename: E J
authors.initials: EJ
authors.lastname: Laing
authors.forename: P J
authors.initials: PJ
authors.lastname: Fitzpatrick
authors.forename: A G
authors.initials: AG
authors.lastname: Binnington
authors.forename: A M
authors.initials: AM
authors.lastname: Norris
authors.forename: A
authors.initials: A
authors.lastname: Mosseri
authors.forename: W D
authors.initials: WD
authors.lastname: Rider
authors.forename: V E
authors.initials: VE
authors.lastname: Valli
authors.forename: A
authors.initials: A
authors.lastname: Baur
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000532:radiotherapy*; D004285:Dogs; D005069:Evaluation Studies as Topic; D005260:Female; D008223:Lymphoma / Q000532:radiotherapy / Q000662:veterinary*; D008297:Male; D012074:Remission Induction; D014916:Whole-Body Irradiation / Q000379:methods / Q000662:veterinary*