Changes in plasma renin activity and renal immunohistochemically demonstrated renin in carbadox treated pigs.
Carbadox is known to induce toxic effects on the adrenal cortex, resulting in hypoaldosteronism. To study the involvement of carbadox on the renin-angiotensin system, weaned piglets of five weeks old received feed supplemented with 0 (control group), 50, 100, 150 or 200 ppm carbadox. After four weeks the 100 and 150 ppm groups had significantly higher plasma renin activity levels than the control group and after nine weeks plasma renin activity levels of all treated groups were significantly higher than the control group. Five and 10 weeks after carbadox administration, three and two pigs, respectively, of all groups were necropsied and the kidneys were screened for immunohistochemically demonstrated renin. All dosed pigs demonstrated an increase of immunoreactive renin, which was dose- and time-related. From these results it is concluded that carbadox induces activation of the renin-angiotensin system, secondary to the suppressing effect on mineralocorticoid secretion and that these changes may be responsible for part of the clinical picture.
van der Molen
E J
EJ
Central Veterinary Institute, Lelystad, The Netherlands.
van Lieshout
J H
JH
Nabuurs
M J
MJ
Derkx
F H
FH
Lamers
A P
AP
Michelakis
A M
AM
D000284:Administration, Oral; D000818:Animals; D002218:Carbadox / Q000008:administration & dosage* / Q000506:poisoning; D007668:Kidney / Q000032:analysis*; D011810:Quinoxalines / Q000008:administration & dosage*; D012083:Renin / Q000032:analysis* / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects; D013552:Swine / Q000378:metabolism*
D011810:Quinoxalines; D012083:Renin; D002218:Carbadox