[Quantitative evaluation of the nucleolus organizer regions (NORs) in malignant melanoma of the skin: is it a new prognosis index?].
Nucleolar Organizer Region-associated proteins (NORs) have been evaluated on paraffin sections of a series of cutaneous malignant melanomas, stage IA at the time of the initial diagnosis. A significant difference (P less than 0.001) was found between the numbers of AgNORs in the cases which developed metastases and those without metastases: increasing values of AgNORs representing increased risk of metastases.
Gambini
C
C
Sementa
A R
AR
Borgiani
L
L
Massone
L
L
Rovida
S
S
Canepa
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000556:secondary; D008875:Middle Aged; D009367:Neoplasm Staging; D009697:Nucleolus Organizer Region / Q000473:pathology*; D011379:Prognosis; D012307:Risk Factors; D012878:Skin Neoplasms / Q000473:pathology*
La valutazione quantitativa delle regioni organizzatrici del nucleolo (NORs) nel melanoma maligno cutaneo: un nuovo indice prognostico?