The therapeutic effect of human recombinant macrophage colony stimulating factor (CSF-1) in experimental murine metastatic melanoma.
This paper investigates the effect of recombinant human macrophage colony-stimulating factor (CSF-1) on the interaction between mononuclear phagocytes and the metastatic murine melanoma, B16/B16. CSF-1 had no effect on the ability of primary or bone marrow-derived macrophages to kill B16 cells in vitro, nor on their activation for cytotoxicity by gamma interferon plus LPS. However, when administered in vivo, CSF-1 increased the number of monocytes and peritoneal cells in tumor-bearing animals, and led to a significant reduction in the appearance of pulmonary and extra-pulmonary metastatic lesions derived from primary B16 tumors. The results suggest a therapeutic potential for CSF-1 in the treatment of malignancy.
Hume
D A
DA
Department of Cell Biology, M.D. Anderson Cancer Center, Houston, TX 77030.
Donahue
R E
RE
Fidler
I J
IJ
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000627:therapeutic use*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000627:therapeutic use*; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000401:mortality; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D011994:Recombinant Proteins / Q000627:therapeutic use
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor