Comparison of transforming, antimitotic and chromosomal aberration-inducing properties of melphalan and cyclophosphamide.
Melphalan and cyclophosphamide, cytostatics used for cancer therapy, were investigated for their ability to induce morphological transformation of embryonic cells of the golden hamster and to evoke structural chromosome aberrations. The antimitotic action of both drugs was also investigated. Cyclophosphamide, under conditions in which it did not produce either structural chromosomal aberrations or exerted cytotoxic action, induced morphological transformation of hamster cells. Under the experimental conditions melphalan induced morphological transformation of hamster cells at concentrations not inducing chromosomal aberrations.
Chłopkiewicz
B
B
Institute for Drug Research and Control, Warszawa, Poland.
Anuszewska
E
E
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002869:Chromosome Aberrations; D006224:Cricetinae; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008558:Melphalan / Q000494:pharmacology*; D008647:Mesocricetus; D008938:Mitosis / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000187:drug effects / Q000378:metabolism
D003520:Cyclophosphamide; D008558:Melphalan