Bioactivation of nephrotoxic haloalkenes by glutathione conjugation: formation of toxic and mutagenic intermediates by cysteine conjugate beta-lyase.
Dekant
W
W
Institut für Toxikologie, Universität Würzburg, F.R.G.
Vamvakas
S
S
Anders
M W
MW
D000475:Alkenes / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D013437:Carbon-Sulfur Lyases; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000378:metabolism / Q000633:toxicity*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism; D008190:Lyases / Q000378:metabolism*; D009153:Mutagens / Q000378:metabolism*
D000475:Alkenes; D006846:Hydrocarbons, Halogenated; D009153:Mutagens; D008190:Lyases; D013437:Carbon-Sulfur Lyases; C019971:cysteine lyase; D005978:Glutathione