title: Studies on penem antibiotics. II. In vitro activity of SUN5555, a new oral penem.
abstract: The new oral penem antibiotic SUN5555 shows broad antibacterial activity against both aerobic and anaerobic Gram-positive and Gram-negative bacteria. SUN5555 is highly stable against various beta-lactamases. It binds preferentially to the penicillin-binding proteins 2 and 1A of Escherichia coli.
authors.affiliation: Department of Microbiology, Kyoto Pharmaceutical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nishino
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: E
authors.initials: E
authors.lastname: Ohtsu
authors.forename: S
authors.initials: S
authors.lastname: Koizuka
authors.forename: T
authors.initials: T
authors.lastname: Nishihara
authors.forename: H
authors.initials: H
authors.lastname: Adachi
authors.forename: K
authors.initials: K
authors.lastname: Okamoto
authors.forename: M
authors.initials: M
authors.lastname: Ishiguro
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001426:Bacterial Proteins; D015780:Carbapenems; D002352:Carrier Proteins / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D006602:Hexosyltransferases; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007769:Lactams; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism; D046915:Penicillin-Binding Proteins; D010406:Penicillins / Q000378:metabolism; D010458:Peptidyl Transferases; D011485:Protein Binding
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D002352:Carrier Proteins; D007769:Lactams; D046915:Penicillin-Binding Proteins; D010406:Penicillins; C060114:SUN 5555; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase