[A clinical evaluation of rush immunotherapy in adult patients with severe bronchial asthma].
Rush immunotherapy (RIT) using house dust (HD) antigen were performed in ten adult patients with chronic severe bronchial asthma who had mite allergy. All cases have reached to the maintenance dose of 10(-1) X 0.50 ml within 10 days and been able to introduce maintenance therapy smoothly. After the RIT, remarkable improvement of asthmatic symptom was seen in 4 cases and one of them was considered to be completely cured of the asthma. Although side effects such as local skin reaction, rhinorrhea and asthmatic attack were seen, severe side effect was not observed at all. IgE-RAST scores for both HD and mite were unchanged before and after RIT. On the other hand, the values of specific IgG4 for both HD and mite antibody were significantly increased 2 or 4 weeks after RIT. These results indicated that RIT can be performed safely and securely, and rapid immunological response as well as clinical effectiveness are able to be expected for adult severe asthmatics.
Nagata
M
M
Yamamoto
H
H
Tabe
K
K
Tanaka
K
K
Kimura
I
I
Sakamoto
K
K
Sakamoto
Y
Y
Yamamoto
K
K
Dohi
Y
Y
D000293:Adolescent; D000328:Adult; D000818:Animals; D000941:Antigens / Q000008:administration & dosage* / Q000627:therapeutic use; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D004391:Dust; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology
D000941:Antigens; D004391:Dust; D007074:Immunoglobulin G