New-onset diabetes mellitus as a harbinger of pancreatic carcinoma. A case report and literature review.
We report the case of a middle-aged man with a 6-month history of diabetes treated with insulin. He was referred for diabetes control and education. Six weeks after we saw him, he was euglycemic (hemoglobin, Hgb A1C 5.9%), but returned because of weight loss, diarrhea, and abdominal cramps. Pancreatic adenocarcinoma was diagnosed. We review the literature on the relationship between diabetes mellitus and pancreatic carcinoma with particular emphasis on situations in which recent-onset diabetes may be a harbinger of pancreatic carcinoma. Several reports are cited in which the onset of diabetes mellitus in middle-aged patients antedated by a short time the onset of clinically recognizable pancreatic carcinoma. An otherwise silent pancreatic carcinoma may present as new-onset diabetes. Although rare, pancreatic carcinoma should be considered in a recently diagnosed middle-aged diabetic person with unusual manifestations, e.g., abdominal symptoms and continuous weight loss despite euglycemia.
Rosa
J A
JA
Division of Endocrinology, University of Connecticut School of Medicine, Farmington, Connecticut.
Van Linda
B M
BM
Abourizk
N N
NN
D000230:Adenocarcinoma / Q000150:complications*; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications*; D012307:Risk Factors; D013997:Time Factors