Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.
The malaria parasite Plasmodium falciparum contains at least two genes related to the mammalian multiple drug resistance genes, and at least one of the P. falciparum genes is expressed at a higher level and is present in higher copy number in a strain that is resistant to multiple drugs than in a strain that is sensitive to the drugs.
Wilson
C M
CM
Department of Tropical Public Health Harvard School of Public Health, Boston, MA 02115.
Serrano
A E
AE
Wasley
A
A
Bogenschutz
M P
MP
Shankar
A H
AH
Wirth
D F
DF
D018528:ATP-Binding Cassette Transporters; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004351:Drug Resistance / Q000235:genetics; D005784:Gene Amplification; D007447:Invertebrate Hormones / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D010963:Plasmodium falciparum / Q000235:genetics*; D015800:Protozoan Proteins; D012689:Sequence Homology, Nucleic Acid
D018528:ATP-Binding Cassette Transporters; D007447:Invertebrate Hormones; D015800:Protozoan Proteins; C059987:mdr gene protein, Plasmodium