High-dose chemotherapy, total abdomen irradiation and autologous bone marrow infusion in ovarian cancer: an observation.
A case of treatment of an ovarian adenocarcinoma (stage IIIc of the IFGO) is reported. The patient underwent a maximal tumor reduction followed by polychemotherapy. After this treatment, a 'second-look' laparotomy shows an incomplete remission. An intensive chemotherapy with total abdomen irradiation and protection of medullary toxicity by an autologous bone marrow infusion is performed, with a satisfactory result, without relapse, 16 months after this treatment (or 25 months after the first laparotomy). Reasons which led the authors to perform an autograft and the conditions under which this treatment may be offered are then presented.
Norès
J M
JM
Department of Internal Medicine, University of Paris, Hôpital Raymond-Poincaré, Garches, France.
Dalayeun
J F
JF
Otmezguine
Y
Y
Folgoas
C
C
Nenna
A D
AD
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011379:Prognosis