Nonmelanoma skin cancers in the elderly.
This article discusses the relationship between aging and development of nonmelanoma skin cancer. Possible age-related risk factors for development of such cancers are cumulative exposure to ultraviolet irradiation from the sun, decreased DNA repair capacity, decreased immunosurveillance, reduced melanocyte density, and altered dermal matrix. Clinical features of basal-cell carcinoma, squamous-cell carcinoma, and keratoacanthoma are discussed.
Lin
A N
AN
Laboratory for Investigative Dermatology, Rockefeller University, New York, New York.
Carter
D M
DM
Balin
A K
AK
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002280:Basal Cell Carcinoma / Q000175:diagnosis / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007636:Keratoacanthoma / Q000175:diagnosis / Q000628:therapy; D007642:Keratosis / Q000209:etiology / Q000628:therapy; D012878:Skin Neoplasms / Q000175:diagnosis / Q000628:therapy