Fluoxetine versus amineptine in the treatment of outpatients with major depressive disorders.
Fluoxetine, a selective serotonin reuptake inhibitor, was compared to amineptine, a tricyclic antidepressant agent, in the treatment of 63 outpatients with major depressive disorders of mild or moderate severity. Patients were randomly assigned to 6 weeks of treatment with either fluoxetine or amineptine. Fluoxetine was found to have a more marked therapeutic effect than that of amineptine: better efficacy, fewer side-effects, and quicker and better improvement on the self evaluation scales.
Ferreri
M
M
Hôpital Saint Antoine, Paris, France.
D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy*; D003986:Dibenzocycloheptenes / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic
D003986:Dibenzocycloheptenes; D005473:Fluoxetine; C011597:amineptin