Strategy for purification of coagulation factor concentrates.
Advances in biotechnology are permitting significant changes in traditional plasma fractionation schemes. Increases in product purity, safety, and recovery are possible, and new products are being developed. Applications of technology to the purification of factor IX, factor X, protein C, antithrombin III, thrombin, and fibrin glue are described.
Clark
D B
DB
American Red Cross, Jerome H. Holland Laboratory, Biomedical Sciences, Rockville, MD 20855.
Drohan
W N
WN
Miekka
S I
SI
Katz
A J
AJ
D001779:Blood Coagulation Factors / Q000302:isolation & purification*; D005591:Chemical Fractionation / Q000379:methods*; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D006358:Hot Temperature; D010949:Plasma / Q000032:analysis; D014780:Viruses / Q000187:drug effects
D001779:Blood Coagulation Factors