title: The captopril test: an aid to investigation of hypertension.
abstract: Twenty three children aged from 5 to 16 with mild to moderate hypertension were investigated using the orally active angiotensin converting enzyme inhibitor captopril. Falls in both systolic and diastolic blood pressure after a single dose of captopril were significantly correlated with initial plasma renin activity. In addition, some information about the aetiology of hypertension was deduced from the renin response to captopril. The blood pressure response to captopril is a useful screening test for renin dependent hypertension in childhood.
authors.affiliation: Renal Unit, Hospital for Sick Children, London.
authors.forename: C E
authors.initials: CE
authors.lastname: Daman Willems
authors.forename: V
authors.initials: V
authors.lastname: Shah
authors.forename: M
authors.initials: M
authors.lastname: Uchiyama
authors.forename: M J
authors.initials: MJ
authors.lastname: Dillon
mesh_terms: D000293:Adolescent; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood / Q000175:diagnosis*; D012083:Renin / Q000097:blood; D013997:Time Factors
chemical_list: D002216:Captopril; D012083:Renin