Treatment of fibromyalgia syndrome.
The therapeutic role of medications in fibromyalgia is reviewed. The tricyclics, amitriptyline and cyclobenzaprine, have been the most extensively evaluated, and in controlled studies have proven to be more effective than placebo or NSAIDs. Their mode of action is not known, but their effect may relate to a number of potential mechanisms. However, neither the tricyclics nor any other medication has provided long-term, clinically meaningful improvement in the majority of patients.
Goldenberg
D L
DL
Tufts University School of Medicine, Boston, Massachusetts.
D000639:Amitriptyline / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D005356:Fibromyalgia / Q000188:drug therapy* / Q000628:therapy; D006801:Humans; D013577:Syndrome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; C004704:cyclobenzaprine