[Autoimmune chronic hepatitis in children].
Autoimmune chronic hepatitis is a clinical syndrome of unknown aetiology with serious prognosis. The disease poses also important problems. During 4 years 11 children with autoimmune chronic hepatitis were observed, among them 10 girls and 1 boy aged from 8 to 16 years. The diagnosis was based on histological examinations, clinical symptoms and biochemical investigations. In all cases the level of gamma-globulin was raised over 20 g/l, with increased concentrations of immunoglobulin G and bile acids, and increased A1AT activity. Abnormal results of the antipyrin test were found in 4 children, and presence of tissue antibodies was demonstrated in 8 children. All children were treated with prednisone. After 2 years of treatment control histological examinations were done in 5 cases. Despite the use of glycocorticosteroids full remission was not obtained in any case. This observation agrees with literature data indicating that autoimmune chronic hepatitis is a long-standing process leading to cirrhosis.
Nałecz
A
A
Janowicz
W
W
Pawłowska
J
J
Socha
J
J
D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000188:drug therapy; D002648:Child; D002908:Chronic Disease; D005260:Female; D006505:Hepatitis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008099:Liver / Q000276:immunology; D008111:Liver Function Tests; D008297:Male; D011241:Prednisone / Q000627:therapeutic use
D001323:Autoantibodies; D011241:Prednisone
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