[The kinetics of bacterial killing by fluctuating concentrations of antibiotics].
Differences in kill kinetics and the regrowth pattern of bacteria under the influence of various antibiotics are frequently not represented by their MIC values. The area under the concentration curve represents antimicrobial activity more accurately than the peak concentration. Readministration of antibiotics should occur prior to bacterial regrowth for optimal efficacy. When administering combinations of antibiotics non-simultaneous dosing is superior to simultaneous administration.
Guggenbichler
J P
JP
Universitätsklinik für Kinderheilkunde, Innsbruck.
Allerberger
F
F
Bonatti
H
H
Semenitz
E
E
Dierich
M P
MP
D000667:Ampicillin / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001431:Bacteriological Techniques / Q000295:instrumentation; D002439:Cefotaxime / Q000494:pharmacology; D015169:Colony Count, Microbial / Q000295:instrumentation; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D012706:Serratia marcescens / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013845:Thienamycins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D013845:Thienamycins; D000667:Ampicillin; D002439:Cefotaxime; C015537:thienamycin; D010878:Piperacillin
Absterbekinetik von Keimen unter fluktuierenden Konzentrationen von Antibiotika.