title: Local anaesthesia of the trachea and mucus secretion.
abstract: We have tested whether two local anaesthetics, in the lumen of cat trachea in vivo, would block the stimulation of mucus secretion by parasympathetic nerves without altering its stimulation by a cholinergic drug. Lignocaine, 4.3-43 mM (0.1-1%) in Krebs-Henseleit, increased the output of mucus macromolecules. It abolished secretion in response to vagus nerve stimulation, but also diminished the effect of 5 microM pilocarpine. Tetrodotoxin, 50 microM, abolished vagal control of secretion without inhibiting pilocarpine's action or changing resting secretion. Though lignocaine blocks nerve-mediated secretion, its action is not simply on nerve conduction. In contrast, the effect of tetrodotoxin may be restricted to the blocking of nerves.
authors.affiliation: Department of Physiology, St George's Medical School, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Somerville
authors.forename: P S
authors.initials: PS
authors.lastname: Richardson
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D008012:Lidocaine / Q000494:pharmacology; D009093:Mucus / Q000378:metabolism*; D010862:Pilocarpine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology; D014132:Trachea / Q000294:innervation / Q000378:metabolism*; D014630:Vagus Nerve / Q000187:drug effects
chemical_list: D000779:Anesthetics, Local; D010862:Pilocarpine; D013779:Tetrodotoxin; D008012:Lidocaine