title: Impaired response of main pancreatic duct to secretin stimulation in early chronic pancreatitis.
abstract: In the present study we compared sonographic measurements of the main pancreatic duct (MPD) following maximal secretin stimulation (75 CU intravenous in 1 min) in 15 chronic pancreatitis patients (CP) with those of 18 normal control subjects. The mean caliber of the main pancreatic duct was 1.2 +/- 0.4 mm in controls and 1.8 +/- 0.9 in patients with chronic pancreatitis (P less than 0.025). In the control group a dilatation of the duct with a peak at the third minute was found. In patients with chronic pancreatitis a flatter profile of the response curve with a slower increase and inconstant return to basal values was found. A statistically significant difference was found between absolute variations of MPD caliber over basal values (1.7 +/- 1.06 in controls vs 0.8 +/- 0.69 in CP, P less than 0.005) and the dilatation index [(Dmax - D)/D] (1.31 +/- 0.6 in controls vs 0.66 +/- 0.69 in CP, P less than 0.005). The mean percent increase at the third minute was 131% in control subjects vs 53% of patients with CP (P less than 0.0005). In the five cases of CP showing a caliber increase greater than 100%, a persistent dilatation (100-200%) was found 15 min after secretin administration. At this time, the mean percent increase over basal value in controls was 25%.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine and Gastroenterology, University of Bologna, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Bolondi
authors.forename: S
authors.initials: S
authors.lastname: Li Bassi
authors.forename: S
authors.initials: S
authors.lastname: Gaiani
authors.forename: V
authors.initials: V
authors.lastname: Santi
authors.forename: L
authors.initials: L
authors.lastname: Gullo
authors.forename: L
authors.initials: L
authors.lastname: Barbara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004106:Dilatation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010183:Pancreatic Ducts / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D010195:Pancreatitis / Q000473:pathology / Q000503:physiopathology*; D012633:Secretin / Q000494:pharmacology*; D014463:Ultrasonography
chemical_list: D012633:Secretin