Termination of pregnancy with mifepristone after intra-uterine death. Clinical and hormonal effects.
Mifepristone was used in a dosage of 400 mg/d in a double-blind study to induce labour in patients with intra-uterine fetal death in late pregnancy. Eight of 12 patients who received the drug delivered within 72 hours while only 2 of 12 patients treated with placebo delivered during a similar period. No adverse effects, viz. excessive vaginal bleeding and abnormal biochemical or haematological parameters, were associated with the use of this drug.
Padayachi
T
T
Department of Obstetrics, University of Natal, Durban.
Moodley
J
J
Norman
R J
RJ
Heyns
A
A
D000019:Abortifacient Agents / Q000494:pharmacology*; D000021:Abortifacient Agents, Steroidal / Q000494:pharmacology*; D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004958:Estradiol / Q000097:blood; D004963:Estrenes / Q000494:pharmacology*; D005260:Female; D005313:Fetal Death; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007751:Labor, Induced / Q000379:methods*; D015735:Mifepristone; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D013997:Time Factors
D000019:Abortifacient Agents; D000021:Abortifacient Agents, Steroidal; D006063:Chorionic Gonadotropin; D004963:Estrenes; D015735:Mifepristone; D011374:Progesterone; D004958:Estradiol; D006854:Hydrocortisone