Pentamidine for the prevention and treatment of P. carinii pneumonia.
Pentamidine is effective in both the treatment and the prevention of Pneumocystis carinii pneumonia. The agent may be administered by slow intravenous infusion or aerosol, although intravenous therapy is associated with a wide range of adverse reactions, including nephrotoxicity, hypoglycemia and neutropenia. Toxic effects may occur in up to 25 percent of patients.
Molavi
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Division of Infectious Diseases, Hahnemann University School of Medicine, Philadelphia, Pennsylvania.
D000336:Aerosols; D000578:Amidines / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D010419:Pentamidine / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy* / Q000517:prevention & control
D000336:Aerosols; D000578:Amidines; D010419:Pentamidine