Biochemically detected HLA-DQ polymorphism in DR-matched donors and recipients of renal allografts.
We performed a retrospective biochemical analysis of HLA-D-region antigens of serologically DR-compatible donors and recipients of renal allografts. No incompatible D-region antigens were detected in grafts with a stable clinical course--i.e., there were no rejection episodes--whereas incompatibility for one or more D-region antigens was found in all 13 grafts with rejection. Thus, mismatched D-region antigens may provide a stimulus for early rejection in these grafts.
Carter
C
C
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, United Kingdom.
Fuggle
S V
SV
Ting
A
A
Morris
P J
PJ
D002460:Cell Line; D015180:Electrophoresis, Gel, Two-Dimensional; D006683:HLA-DQ Antigens / Q000032:analysis / Q000235:genetics*; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics; D006650:Histocompatibility Testing; D016030:Kidney Transplantation; D011110:Polymorphism, Genetic; D014019:Tissue Donors; D014184:Transplantation, Homologous
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens