title: In vitro screens from CNS, liver and kidney for systemic toxicity.
abstract: The development and evaluation of in vitro systems from target organs for preliminary assessments of the potential for systemic toxic effects has been receiving increased attention. This review presents a synopsis of progress made in developing toxicity screens for three common target organs and identifies further work needed for more complete validation.
authors.affiliation: SRI International, Menlo Park, California.
authors.forename: C A
authors.initials: CA
authors.lastname: Tyson
authors.forename: N H
authors.initials: NH
authors.lastname: Stacey
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D014116:Toxicology / Q000379:methods*