title: Lymphocyte subpopulations in mother and newborn: correlation with sex of the newborn and number of pregnancies.
abstract: T cell subsets were defined with monoclonal antibodies of the OKT series, OKT3, OKT4 and OKT8, in 23 male and 22 female newborns and in their mothers 4-10 h after delivery. The data were compared and statistically evaluated between mother and newborn, between male and female newborns as well as between parity groups. The results indicate that the distribution of OKT4 and OKT8+ cells is different in mother and newborn and a significantly increased percentage of OKT4+ cells and a significantly decreased percentage of OKT3+ cells was observed in newborns as compared to their mothers after the first and second delivery. For maternal cells from male as compared to female newborns the percentage of OKT4+ was significantly decreased after the second delivery. OKT8+ cells in the mother were significantly decreased after the second as well as after three or more deliveries of male as compared to female newborns. With increasing parity the percentage of OKT3+, OKT4+ and OKT8+ cells decreased slowly for both sexes and the difference was significant between primi- and multiparae. The present findings suggest a possible role of the newborn sex and of parity in the distribution of specific T cell subsets in mother and newborn shortly after delivery.
authors.affiliation: B. Gattegno Research Institute of Human Reproduction and Fetal Development, Hasharon Hospital, Petah Tiqva, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Komlos
authors.forename: J
authors.initials: J
authors.lastname: Landmann
authors.forename: J
authors.initials: J
authors.lastname: Notmann
authors.forename: D
authors.initials: D
authors.lastname: Aloni
authors.forename: F
authors.initials: F
authors.lastname: Dulitzky
authors.forename: J
authors.initials: J
authors.lastname: Goldman
authors.forename: I
authors.initials: I
authors.lastname: Halbrecht
mesh_terms: D000911:Antibodies, Monoclonal; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007231:Infant, Newborn / Q000276:immunology*; D007743:Labor, Obstetric; D008297:Male; D010298:Parity; D011247:Pregnancy / Q000276:immunology*; D012723:Sex; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D013997:Time Factors
chemical_list: D000911:Antibodies, Monoclonal