[Assay of plasma isosorbide dinitrate and its metabolites after oral administration of immediate and delayed-action forms].
This paper describes a kinetic comparative study of plasma concentrations of isosorbide dinitrate (ISDN) and its mononitrate derivatives (2-ISMN or 5-ISMN) after oral administration of a sustained release form of ISDN or a (non) sustained release form of 5-ISMN. The blood extracts determinations were performed by electron capture gas chromatography which is an accurate and sensitive method suitable for the quantitation of concentrations in the nanogram per ml range. The results are in good agreement with those of the literature. The standard form of 5-ISMN is rapidly absorbed. The Tmax value is approximately 1H with a corresponding Cmax value close to 400 ng/ml. For the sustained release drugs, the Tmax increases to 6H and Cmax is nearly half the 5-ISMN standard form value. Considering the administered dose, it seems better to use 5-ISMN than ISDN. For a long lasting treatment of angina pectoris and ischaemic cardiac diseases, both forms can be used.
Audry
E
E
Dallet
P
P
Dubost
J P
JP
Langlois
M H
MH
Ernouf
D
D
Narcisse
G
G
D000284:Administration, Oral; D000368:Aged; D003692:Delayed-Action Preparations; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D003692:Delayed-Action Preparations; D007548:Isosorbide Dinitrate
Dosage plasmatique du dinitrate d'isosorbide et de ses métabolites après administration orale de formes à libération immédiate ou prolongée.