title: Mechanisms of aminoglycoside nephrotoxicity.
abstract: Aminoglycosides continue to be widely used for the treatment of serious Gram-negative infections. Ten to fifteen per cent of all courses of therapy are complicated by declines in renal function, despite close monitoring of serum drug levels. The proposed pathogenesis and biochemical mechanisms of renal dysfunction caused by these commonly used therapeutic agents are discussed.
authors.affiliation: Department of Medicine, Oregon Health Sciences University, Portland 97201.
authors.forename: W M
authors.initials: WM
authors.lastname: Bennett
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents