title: Evidence of coordinate regulation of virulence in Salmonella typhimurium involving the rsk element of the 95-kilobase plasmid.
abstract: Integration of the Salmonella typhimurium virulence plasmid into the chromosome reduces mouse virulence, serum resistance, and HeLa cell adhesion-invasion while prolonging lag time in minimal medium. The proposed virulence plasmid regulatory element, rsk, partially restores virulence and fully restores the other three phenotypes to wild-type levels. Plasmid curing reduces virulence without affecting the other phenotypes. rsk has no apparent effect on the cured strain.
authors.affiliation: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109.
authors.forename: J L
authors.initials: JL
authors.lastname: Vandenbosch
authors.forename: D R
authors.initials: DR
authors.lastname: Kurlandsky
authors.forename: R
authors.initials: R
authors.lastname: Urdangaray
authors.forename: G W
authors.initials: GW
authors.lastname: Jones
mesh_terms: D000818:Animals; D001482:Base Composition; D005798:Genes, Bacterial; D051379:Mice; D010957:Plasmids; D012045:Regulatory Sequences, Nucleic Acid; D012486:Salmonella typhimurium / Q000235:genetics / Q000472:pathogenicity*; D014774:Virulence