The mutagenic and carcinogenic properties of three second generation antitumour platinum compounds: a comparison with cisplatin.
The cytotoxicity, mutagenicity and transforming potentials of three second generation platinum compounds have been investigated in mammalian cells. All the compounds showed positive response in two assay systems in Chinese hamster V 79 cells, i.e. measurement of mutation induction at the HGPRT locus and of DNA damage as indicated by sister chromatid exchange frequencies. At equitoxic doses, the compounds in order of decreasing mutagenicities were cisplatin, spiroplatin, carboplatin and iproplatin. The BHK transformation assay reflected a similar order in the potential carcinogenicity of the drugs. Cisplatin was highly carcinogenic, followed by spiroplatin. In comparison, carboplatin and iproplatin were potentially weak carcinogens.
Chibber
R
R
Department of Biology, Southampton University, Hants, U.K.
Ord
M J
MJ
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D016190:Carboplatin; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D002478:Cells, Cultured; D002945:Cisplatin / Q000633:toxicity; D006224:Cricetinae; D004249:DNA Damage; D009153:Mutagens / Q000633:toxicity*; D009944:Organoplatinum Compounds / Q000633:toxicity; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013866:Thioguanine / Q000494:pharmacology
D000970:Antineoplastic Agents; D009153:Mutagens; D009944:Organoplatinum Compounds; C023359:iproplatin; C024236:1,2-diaminocyclohexyl platinum sulfate; D016190:Carboplatin; D013866:Thioguanine; D002945:Cisplatin