[Prolonged posttetanic potentiation in slices of mouse hippocampus with the "kindling" phenomenon].
The characteristics of long-term potentiation (LTP) in Schaffer collaterals--CA1 system were compared in hippocampal slices from mice of control group and mice with pentylenetetrazol (PTZ) kindling, induced by daily i.p.-injection of 30 mg/kg of PTZ. The increase in LTP mean magnitude was found in the preparation from kindled mice. The enhancement of the paired-pulse potentiation was also shown in these slices. It is suggested that both the increase in LTP and paired-pulse potentiation are due to the depression of an inhibition in intrahippocampal synaptic systems.
Buldakova
S L
SL
Peniazeva
G A
GA
D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007696:Kindling, Neurologic / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008839:Microelectrodes; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D010433:Pentylenetetrazole / Q000494:pharmacology; D013997:Time Factors
D010433:Pentylenetetrazole
Dlitel'naia posttetanicheskaia potentsiatsiia v srezakh gippokampa mysheĭ s fenomenom "raskachki".