title: The late results of renal transplantation and the importance of chronic rejection as a cause of graft loss.
abstract: The results of 279 renal transplants performed in a single centre between 1974 and 1986 are reviewed. Improvements in the management of acute rejection and a reduction in mortality have resulted in an improvement in 1-year actuarial graft survival rates from 44% for transplants performed before 1980 to 68% for those performed after 1983. After the second year post-transplant there has been a steady rate of graft failure (6% per annum), mainly due to chronic rejection. In total 52 grafts have developed chronic rejection (19% of the total and 30% of those at risk at 6 months). Chronic rejection is assuming greater relative importance as a cause of graft loss as early results improve.
authors.affiliation: Department of Surgery, City Hospital, Nottingham.
authors.forename: M C
authors.initials: MC
authors.lastname: Foster
authors.forename: P W
authors.initials: PW
authors.lastname: Wenham
authors.forename: P A
authors.initials: PA
authors.lastname: Rowe
authors.forename: R P
authors.initials: RP
authors.lastname: Burden
authors.forename: A G
authors.initials: AG
authors.lastname: Morgan
authors.forename: R E
authors.initials: RE
authors.lastname: Cotton
authors.forename: R W
authors.initials: RW
authors.lastname: Blamey
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000401:mortality; D016030:Kidney Transplantation; D008297:Male; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents