Role of gastric inhibitory polypeptide in altered glucose metabolism after removal of the jejunum in dogs.
To investigate the role of gastric inhibitory polypeptide (GIP) in the abnormal glucose metabolism occurring after resection of the small intestine, we performed a serial observation on secretion of GIP in dogs before and after removal of the jejunum. After removal of the jejunum, glucose intolerance was observed when glucose was administered intraduodenally but not intravenously. Significant decreases were simultaneously observed in the responses of both insulin and GIP 1, 3, and 6 months after the surgery compared with the preoperative controls. The insulin response to intravenous glucose was not altered by removal of the jejunum. The response of GIP to intraduodenal lipid also remained decreased for 6 months after the operation. These results indicate that the GIP deficiency caused by removal of the jejunum may play a role in the poor insulin response to luminal stimuli, which contributes to glucose intolerance.
Tanaka
Y
Y
First Department of Surgery, Osaka University Medical School, Japan.
Miyata
M
M
Hamaji
M
M
Izukura
M
M
Nakamura
M
M
Kawashima
Y
Y
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004285:Dogs; D004386:Duodenum; D005223:Fats / Q000494:pharmacology; D005749:Gastric Inhibitory Polypeptide / Q000502:physiology*; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D007262:Infusions, Intravenous; D007267:Injections; D007328:Insulin / Q000097:blood; D007583:Jejunum / Q000601:surgery*; D011184:Postoperative Period
D001786:Blood Glucose; D005223:Fats; D007328:Insulin; D005749:Gastric Inhibitory Polypeptide; D005947:Glucose