title: Plasmodium falciparum-infected erythrocytes form spontaneous erythrocyte rosettes.
abstract: Erythrocytes infected with trophozoites or schizonts of Plasmodium falciparum bind uninfected erythrocytes, leading to rosette formation. Both established laboratory strains and fresh isolates from patients form such rosettes, but at widely different frequencies. IgG preparations from the serum of some P. falciparum-immune donors and heparin inhibited rosette formation. The results indicate that cytoadherence of infected erythrocytes to endothelial cells and rosetting represent distinct genetic traits.
authors.affiliation: Department of Immunology, University of Stockholm, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Udomsangpetch
authors.forename: B
authors.initials: B
authors.lastname: Wåhlin
authors.forename: J
authors.initials: J
authors.lastname: Carlson
authors.forename: K
authors.initials: K
authors.lastname: Berzins
authors.forename: M
authors.initials: M
authors.lastname: Torii
authors.forename: M
authors.initials: M
authors.lastname: Aikawa
authors.forename: P
authors.initials: P
authors.lastname: Perlmann
authors.forename: M
authors.initials: M
authors.lastname: Wahlgren
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002478:Cells, Cultured; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology / Q000469:parasitology*; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008854:Microscopy, Electron; D010963:Plasmodium falciparum / Q000502:physiology*; D012397:Rosette Formation; D014357:Trypsin / Q000494:pharmacology
chemical_list: D007074:Immunoglobulin G; D006493:Heparin; D014357:Trypsin