[The action of a fibric acid derivative on lipid metabolism].
The action of N-2 (p-chlorophenoxy isobutiril)-N-morpholino-methylureea on some serum lipids parameters in rats with normolipemia and tritonic hyperlipidemia was studied. In the animals with normolipidemia, the compound induces hypocholesterolemia beginning with the 5th day of treatment, hypotriglyceridemia during the entire investigation interval and an increase of phospholipid levels in the 9th day of treatment. In the rats with tritonic hyperlipidemia, the substance induces hypocholesterolemia, hypotriglyceridemia, increase of HDL-cholesterol levels, decrease of (VLDL + LDL)--cholesterol levels and the return to normal values of Glueck ratio.
Filip
M
M
Păduraru
I
I
Nechifor
M
M
Dănilă
G H
GH
Popovici
I
I
Filip
F M
FM
Poşircă
F
F
D000818:Animals; D002994:Clofibrate / Q000031:analogs & derivatives*; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008055:Lipids / Q000097:blood*; D008297:Male; D011092:Polyethylene Glycols; D051381:Rats
D000960:Hypolipidemic Agents; D008055:Lipids; D011092:Polyethylene Glycols; D002995:Clofibric Acid; C016894:plafibride; D002994:Clofibrate
Explorarea acţiuni unui derivat al acidului fibric asupra metabolismului lipidic.