title: A search for bcl1, bcl2, and c-myc oncogene rearrangements in chronic lymphocytic leukemia.
abstract: Three cellular or putative oncogenes: c-myc, bcl1, and bcl2 were previously found to be rearranged in some B cell malignancies due to chromosomal translocations. Data concerning the role of such genetic rearrangements in B-CLL are very scanty and limited to few cases in which bcl1 rearrangements were found. We studied DNA samples from 38 cases of B-CLL by Southern blot technique in order to find out the existence and frequency of such events. No bcl1 or bcl2 rearrangements were found in any of the studied cases; thus, involvement of these genes in CLL must be rare. In one patient who had an aggressive and resistant disease, c-myc rearrangement was found.
authors.affiliation: Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Rechavi
authors.forename: N
authors.initials: N
authors.lastname: Katzir
authors.forename: F
authors.initials: F
authors.lastname: Brok-Simoni
authors.forename: F
authors.initials: F
authors.lastname: Holtzman
authors.forename: M
authors.initials: M
authors.lastname: Mandel
authors.forename: N
authors.initials: N
authors.lastname: Gurfinkel
authors.forename: D
authors.initials: D
authors.lastname: Givol
authors.forename: I
authors.initials: I
authors.lastname: Ben-Bassat
authors.forename: B
authors.initials: B
authors.lastname: Ramot
mesh_terms: D000328:Adult; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male; D015335:Molecular Probes; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D015335:Molecular Probes; D011518:Proto-Oncogene Proteins