title: Plasma erythropoietin activity in diabetes patients, studied by determining the 59Fe incorporation in posthypoxic polycythemic mice.
abstract: The plasma erythropoietin activity in diabetes patients was studied using methods for biological testing on posthypoxic polycythemic mice, based on the incorporation of 59Fe in the newly-formed red blood cells of the animals. The data are read on an automatic scintillation gamma-counter. Considerably higher erythropoietin activity of the plasma obtained from diabetics (p less than 0.01) compared with clinically health individuals has been obtained, as well as a statistically significant difference in the percentage of 59F incorporated in the newly-formed erythrocytes of the animals treated with that plasma, compared with the animals treated with saline. A dependence has been found between the chronic hyperglycaemia and the plasma erythropoietin level.
authors.affiliation: Department of Physiology, Higher Medical Institute, Stara Zagora.
authors.forename: V
authors.initials: V
authors.lastname: Nikolov
authors.forename: V
authors.initials: V
authors.lastname: Kalaydjieva
authors.forename: A
authors.initials: A
authors.lastname: Logofetov
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000150:complications; D007501:Iron / Q000097:blood*; D007504:Iron Radioisotopes; D008074:Lipoproteins / Q000097:blood; D008297:Male; D051379:Mice; D008875:Middle Aged; D011086:Polycythemia / Q000097:blood* / Q000209:etiology
chemical_list: D001786:Blood Glucose; D006454:Hemoglobins; D007504:Iron Radioisotopes; D008074:Lipoproteins; D004921:Erythropoietin; D007501:Iron