title: Negative inotropic and calcium antagonistic activity of alkyl and arylalkyl phosphonates.
abstract: Several alkyl and arylalkyl diethylphosphonates related to fostedil have been synthetized and tested for negative inotropic activity (isolated guinea pig left atrium) and Ca++ antagonistic activity (isolated guinea pig aortic strips). The results show that negative inotropic and Ca++ antagonistic activity might depend from different molecular features.
authors.affiliation: Dipartimento di Scienze Farmaceutiche dell'Universita, Firenze, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Bellucci
authors.forename: F
authors.initials: F
authors.lastname: Gualtieri
authors.forename: S
authors.initials: S
authors.lastname: Scapecchi
authors.forename: E
authors.initials: E
authors.lastname: Teodori
authors.forename: R
authors.initials: R
authors.lastname: Budriesi
authors.forename: A
authors.initials: A
authors.lastname: Chiarini
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology
chemical_list: D002121:Calcium Channel Blockers; D009943:Organophosphorus Compounds; D011189:Potassium Chloride