Transplantable mouse 16/c mammary adenocarcinoma as a model in experimental cancer therapy. II. Modification of tumor-host interactions by therapeutic procedures.
The influence of therapeutic procedures on tumor--host interactions was analysed using 16/c mouse mammary adenocarcinoma model system. After partial removal of tumor burden the growth enhancement of remnant tumor mass was observed. Pretreatment of the host either with cyclophosphmide or X-rays resulted in enhancement of experimental metastasis formation. Unexpectedly, such a procedure caused the growth delay of the primary subcutaneous tumor. The possible mechanisms of observed phenomena are discussed.
Rak
J
J
Department of Tumor Immunology, Polish Academy Sciences, Wroclaw.
Strzadała
L
L
Kuśnierczyk
H
H
Radzikowski
C
C
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000556:secondary; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000532:radiotherapy; D051379:Mice; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation
D000970:Antineoplastic Agents; D003520:Cyclophosphamide