Transplantable mouse mammary adenocarcinoma 16/c as a model in experimental cancer therapy. III. Sensitivity to antitumor drugs.
On the basis of biological characteristics of murine transplantable mammary adenocarcinoma 16/c, experimental conditions optimal for chemotherapeutic experiments were defined. Sensitivity of primary tumor and lung metastases to the treatment with drugs used in breast cancer therapy: cyclophosphamide, 5-fluorouracil and adriamycin was confirmed. These drugs were significantly more effective in combination than when administered as monotherapy. Antimetastatic but not antitumor effect of 5-fluorouracil could be potentiated by using albumin microspheres as a carrier. Usefulness of the tumor model system in experimental chemotherapy is discussed.
Rak
J
J
Department of Tumor Immunology, Polish Academy of Sciences, Wroclaw.
Kuśnierczyk
H
H
Strzadała
L
L
Kłosiewicz
S
S
Radzikowski
C
C
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004317:Doxorubicin / Q000627:therapeutic use*; D005472:Fluorouracil / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy*; D051379:Mice
D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil