Effect of granaticin on the activity of DNA-directed RNA polymerase from Streptomyces granaticolor.
DNA-directed RNA polymerase was isolated from wild-type and mutant (asporogenic and granaticin overproducing) Streptomyces granaticolor. The effect of granaticin on the enzyme activity was compared with that of standard transcription inhibitors, rifampicin and rifamycin SV and shown to be zero.
Smardová
J
J
Institute of Microbiology, Czechoslovak Academy of Sciences, Prague.
Spízek
J
J
Stastná
J
J
Klégr
M
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D009285:Naphthoquinones / Q000494:pharmacology; D013302:Streptomyces / Q000187:drug effects / Q000201:enzymology*; D000095622:Benzoisochromanequinones
D000900:Anti-Bacterial Agents; D012321:DNA-Directed RNA Polymerases; D009285:Naphthoquinones; C009811:granaticin; D000095622:Benzoisochromanequinones