Diglycosyl phenol phthiocerol diester of Mycobacterium leprae.
A diglycosyl phenol phthiocerol diester that had not been previously detected was isolated from M. leprae-infected armadillo tissues. Spectroscopy methods allowed the elucidation of its structure. The diglycoside was a 2,3-di-O-methylrhamnopyranosyl (alpha 1----2)3-O-methylrhamnopyranosyl (alpha 1-linked to the phenolic hydroxyl of phthiocerol dimycocerosates). It differs from the major phenolic glycolipid (PGL I) only by the absence of the terminal 3,6-di-O-methylglucopyranosyl unit. The diglycoside could be an intermediate in the synthesis of the latter antigen or a degradative product in the host detoxification process.
Daffé
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Centre de Recherche de Biochimie et Génétique Cellulaires du CNRS, Université Paul Sabatier, Toulouse, France.
Lanéelle
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MA
D000818:Animals; D001135:Armadillos; D002855:Chromatography, Thin Layer; D006017:Glycolipids / Q000032:analysis; D007918:Leprosy / Q000382:microbiology; D008055:Lipids / Q000302:isolation & purification*; D008099:Liver / Q000382:microbiology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009166:Mycobacterium leprae / Q000378:metabolism*; D010636:Phenols / Q000032:analysis; D013154:Spleen / Q000382:microbiology
D006017:Glycolipids; D008055:Lipids; D010636:Phenols; C008901:phthiocerol dimycocerosate