title: Karnamicin, a complex of new antifungal antibiotics. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.
abstract: A complex of new antifungal antibiotics designated karnamicin was isolated from the cultured broth of Saccharothrix aerocolonigenes No. N806-4. Fifteen components have so far been isolated from the complex; the major component karnamicin B2 was identified by X-ray crystallography to be a novel molecule unrelated to known antibiotics. All components of karnamicin exhibited a rather broad spectrum of activity against fungi and yeasts with MICs ranging from 3.1 to 50 micrograms/ml.
authors.affiliation: Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nishio
authors.forename: K
authors.initials: K
authors.lastname: Tomatsu
authors.forename: M
authors.initials: M
authors.lastname: Konishi
authors.forename: K
authors.initials: K
authors.lastname: Tomita
authors.forename: T
authors.initials: T
authors.lastname: Oki
authors.forename: H
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: J
authors.initials: J
authors.lastname: Clardy
mesh_terms: D000192:Actinomycetales / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology / Q000648:ultrastructure; D000818:Animals; D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005285:Fermentation; D005658:Fungi / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D011725:Pyridines / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013171:Spores, Bacterial; D013844:Thiazoles / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D011725:Pyridines; D013844:Thiazoles; C060115:karnamicin