[Polymer materials for biomedical use obtained by radiation methods. IV. The therapeutic system for local release of prostaglandins].
The suitability of a radiation crosslinked polyvinylpyrrolidone++ as a therapeutical system for local prostaglandin monitoring has been studied. The effect of the dose and dose rate of ionizing radiation and of the time of heating the matrix on the content of gel fraction and the degree of hydrogel swelling was determined. The dimensions of a polymer network as dependent on the parameters of the process were calculated. For a chosen way of obtaining the therapeutical system, the release of prostaglandin F2 alpha in vitro was also estimated.
Rosiak
J
J
Miedzyresortowy Instytut Techniki Radiacyjnej Politechniki Lódzkiej.
Olejniczak
J
J
D000021:Abortifacient Agents, Steroidal; D000028:Abortion, Induced / Q000379:methods*; D003037:Cobalt Radioisotopes / Q000008:administration & dosage; D003432:Cross-Linking Reagents / Q000494:pharmacology; D015237:Dinoprost / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007434:Intrauterine Devices; D007751:Labor, Induced / Q000379:methods*; D010120:Oxytocics; D011205:Povidone / Q000138:chemical synthesis / Q000528:radiation effects; D011247:Pregnancy; D011829:Radiation Dosage; D013678:Technology, Pharmaceutical / Q000379:methods*
D000021:Abortifacient Agents, Steroidal; D003037:Cobalt Radioisotopes; D003432:Cross-Linking Reagents; D010120:Oxytocics; D015237:Dinoprost; D011205:Povidone
Materiały polimerowe do celów biomedycznych otrzymywane metodami radiacyjnymi. IV. System terapeutyczny dla lokalnego uwalniania prostaglandyn.