Neoplastic lesions induced by 1,3-butadiene in B6C3F1 mice.
1,3-butadiene (CAS No. 106-99-0) was evaluated for carcinogenicity and chronic toxicity by inhalation exposure in B6C3F1 mice because of its high production volume, widespread exposure of workers, and the lack of carcinogenicity and toxicity data (NTP Report #228, 1984). Butadiene (BD) had long been considered to have low toxicity. The long-term studies established that BD is a potent mouse carcinogen with multiple organ carcinogenicity (Huff et al. 1985; Melnick et al. 1988). This paper presents morphological descriptions and illustrations of the neoplastic lesions induced by 1,3-butadiene in B6C3F1 mice.
Miller
R A
RA
Battelle, Pacific Northwest Laboratories, Richland, WA 99352.
Melnick
R L
RL
Boorman
G A
GA
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology; D000236:Adenoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D002070:Butadienes / Q000009:adverse effects*; D002277:Carcinoma / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006106:Granulosa Cell Tumor / Q000139:chemically induced / Q000473:pathology; D006338:Heart Neoplasms / Q000139:chemically induced / Q000473:pathology; D006394:Hemangiosarcoma / Q000139:chemically induced / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000473:pathology; D008223:Lymphoma / Q000139:chemically induced / Q000473:pathology; D008297:Male; D051379:Mice; D009153:Mutagens / Q000009:adverse effects*; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000139:chemically induced / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000473:pathology
D002070:Butadienes; D009153:Mutagens; C031763:1,3-butadiene