Progress in angiotensin-converting enzyme inhibition in heart failure: rationale, mechanisms, and clinical responses.
The pharmacology and mechanisms of action of angiotensin-converting enzyme (ACE) inhibitors are reviewed in this article together with discussions on their acute and hemodynamic effects; influence on regional blood flow and renal responses; clinical efficacy and adverse effects; and their impact on survival in severe congestive heart failure.
Dzau
V J
VJ
Department of Medicine, Harvard Medical School, Boston, Massachusetts.
Creager
M A
MA
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D001775:Blood Circulation / Q000187:drug effects; D002986:Clinical Trials as Topic; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy; D011897:Random Allocation; D012084:Renin-Angiotensin System / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors