[Research on the psychopharmacologic profile of new barbiturics].
The detection of psychopharmacological properties of 8 synthetic substances derived from barbituric didn't allow to consider the existence of well characterised psychotropic properties, particularly hypnotical, but only antalgic and sedative effects (or stimulating activity very low). If the presence of a benzyl substituent can confer an affinity for the nervous central system superior to the one developed when an allyl rest is in the same position, the presence of an OH or OCH3 in other place inverse the sedative character in stimulant potentiality.
Guimbal
C
C
Wissocq
F
F
Bretaudeau
J
J
Foussard-Blanpin
O
O
D000818:Animals; D001463:Barbiturates / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010146:Pain / Q000188:drug therapy; D011600:Psychopharmacology
D001463:Barbiturates
Recherche du profil psychopharmacologique de nouveaux barbituriques.