Involvement of tumour necrosis factor and other cytokines in immune-mediated vascular pathology.
Vascular endothelial cells are actively involved in coagulation and inflammation processes and appear to represent an important element in cell-mediated immune responses. In this paper, the possible role of endothelial cells as a target for immunopathological reactions was analyzed. Experimental neurovascular lesions were studied in a model of cerebral malaria, with particular attention to the role of cytokine interactions in vivo.
Grau
G E
GE
Department of Pathology, University of Geneva, Switzerland.
Piguet
P F
PF
Vassalli
P
P
Lambert
P H
PH
D000818:Animals; D001685:Biological Factors / Q000502:physiology*; D001927:Brain Diseases / Q000473:pathology / Q000503:physiopathology; D016207:Cytokines; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology*; D008264:Macrophages / Q000502:physiology; D008288:Malaria / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D010962:Plasmodium berghei; D013601:T-Lymphocytes / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*; D014657:Vasculitis / Q000473:pathology / Q000503:physiopathology*
D001685:Biological Factors; D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha