Biliary colic treatment and acute cholecystitis prevention by prostaglandin inhibitor.
Sixty patients were treated in the emergency ward for biliary colic. Cholelithiasis was proven by ultrasonography. Twenty patients (group I) were treated by placebo. Twenty patients (group II) were treated by papaverine, and 20 patients were treated by diclofenac sodium (Voltaren) (group III). Twenty more patients (group IV) with low back pain (LBP) were treated with diclofenac sodium (Voltaren) as a control to assess the analgesic effect of Voltaren. Two interesting observations were made: Voltaren was proven more efficient for pain relief (P less than 0.002), and none of the patients treated with Voltaren were in need of hospitalization and immediate surgery. In comparison, nine patients of the other two groups progressed to acute cholecystitis and needed surgical intervention. The possible anticolic and anti-biliary inflammation properties and the indications for use of Voltaren are discussed.
Goldman
G
G
Department of Surgery, A, Ichilov Hospital, Tel-Aviv, Israel.
Kahn
P J
PJ
Alon
R
R
Wiznitzer
T
T
D000208:Acute Disease; D001660:Biliary Tract Diseases / Q000188:drug therapy* / Q000209:etiology; D002764:Cholecystitis / Q000209:etiology / Q000517:prevention & control*; D002769:Cholelithiasis / Q000150:complications / Q000175:diagnosis; D002986:Clinical Trials as Topic; D003085:Colic / Q000188:drug therapy* / Q000209:etiology; D004008:Diclofenac / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000627:therapeutic use; D011448:Prostaglandin Antagonists / Q000627:therapeutic use*; D014463:Ultrasonography
D011448:Prostaglandin Antagonists; D004008:Diclofenac; D010208:Papaverine