title: RNA-catalysed synthesis of complementary-strand RNA.
abstract: The Tetrahymena ribozyme can splice together multiple oligonucleotides aligned on a template strand to yield a fully complementary product strand. This reaction demonstrates the feasibility of RNA-catalysed RNA replications.
authors.affiliation: Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.
authors.forename: J A
authors.initials: JA
authors.lastname: Doudna
authors.forename: J W
authors.initials: JW
authors.lastname: Szostak
mesh_terms: D000818:Animals; D001483:Base Sequence; D007438:Introns; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000378:metabolism; D012326:RNA Splicing; D016337:RNA, Catalytic; D012335:RNA, Ribosomal / Q000235:genetics / Q000378:metabolism*; D013095:Spermidine / Q000494:pharmacology; D013698:Templates, Genetic; D013768:Tetrahymena / Q000235:genetics*
chemical_list: D009841:Oligonucleotides; D016337:RNA, Catalytic; D012335:RNA, Ribosomal; D013095:Spermidine