title: Effect of therapeutic concentrations of anthracyclines on monocyte phagocytosis of yeast cells.
abstract: The effect of therapeutic concentrations of doxorubicin, epirubicin, and mitoxanthrone on mature leukocyte function has been examined by measuring phagocytosis of yeast cells by surface-bound monocytes, using a fluorescence-quenching method. There was a 10% inhibition of monocyte phagocytosis by doxorubicin, but epirubicin and mitoxanthrone had no effect on monocyte phagocytosis. Anthracyclines may have a major immunosuppressive effect due to bone marrow depression. The lack of interference with mature monocyte function by epirubicin and mitoxanthrone provides a potential advantage in comparison with the parent compounds.
authors.affiliation: Department of Surgery, University Hospital, Umeå, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Athlin
authors.forename: L
authors.initials: L
authors.lastname: Domellöf
authors.forename: B
authors.initials: B
authors.lastname: Norberg
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology; D015251:Epirubicin / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008942:Mitoxantrone / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000187:drug effects
chemical_list: D000903:Antibiotics, Antineoplastic; D015251:Epirubicin; D004317:Doxorubicin; D008942:Mitoxantrone