title: Nephrotic syndrome associated with transitional cell carcinoma of the bladder.
abstract: We describe the occurrence of a nephrotic syndrome in association with transitional cell carcinoma of the bladder. The proteinuria disappeared several weeks after removal of the tumor. Light and electron microscopy were compatible with a minimal-change lesion, but immunofluorescence showed linear immunoglobulin deposition. Immunoglobulins eluted from the tumor reacted specifically with the kidney and vice versa. We conclude that antibody formation against a specific component of basement membrane common to both kidney and tumor gave rise to the nephropathy in this case.
authors.affiliation: Department of Nephrology, Soroka Medical Center, Beersheva, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Rapoport
authors.forename: O
authors.initials: O
authors.lastname: Kuperman
authors.forename: Y
authors.initials: Y
authors.lastname: Gopas
authors.forename: E
authors.initials: E
authors.lastname: Maor
authors.forename: A
authors.initials: A
authors.lastname: Eyal
authors.forename: M
authors.initials: M
authors.lastname: Mostovslavski
authors.forename: A
authors.initials: A
authors.lastname: Abuful
authors.forename: C
authors.initials: C
authors.lastname: Chaimovitz
mesh_terms: D001706:Biopsy; D002295:Carcinoma, Transitional Cell / Q000150:complications*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000150:complications*