[Regulation of HTLV-1 gene expression and its relevance to proliferation of the infected cells].
Proliferation of HTLV-1 after infection is one of the crucial steps that affects development of adult T cell leukemia. In addition, one of the regulatory factors, tax protein, activates not only viral transcription from the LTR but also transcription of genes coding IL-2 and IL-2 receptor and eventually supposed to induce proliferation of infected T cells. However, expression of tax protein is regulated negatively by another viral regulatory factor, rex protein, in a novel fashion. The process of ATL development is discussed in relation to the regulation of viral gene expression.
Seiki
M
M
Dept. of Viral Oncology, Cancer Research Institute Kanazawa University.
D002455:Cell Division; D002472:Cell Transformation, Viral; D005786:Gene Expression Regulation; D005814:Genes, Viral; D015486:HTLV-I Antigens / Q000502:physiology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000382:microbiology / Q000473:pathology*; D013601:T-Lymphocytes / Q000382:microbiology / Q000473:pathology; D015534:Trans-Activators; D014157:Transcription Factors / Q000502:physiology
D015486:HTLV-I Antigens; D015534:Trans-Activators; D014157:Transcription Factors