title: [Mixed ovarian germinal neoplasia: adult embryonal carcinoma and dysgerminoma with trophoblasts].
abstract: Malignant mixed germ cell tumor of the ovary: embryonal carcinoma and dysgerminoma with trophoblastic cells. A case of ovarian neoplasia in a 19-years-old woman is described showing mixed germ cell tumor patterns. The main component is a solid embryonal carcinoma with mainly syncytial-like, highly anaplastic cells, displaying diffuse CK-immunoreactivities and scattered PLAP-positive cells. Many CK- and beta-HCG-positive syncytiotrophoblastic and intermediate trophoblastic cells are present. A second component is a dysgerminoma with lymphoid stroma and diffuse PLAP-cytomembrane immunoreactivities: rare cells, to be identified as intermediate trophoblast cells, are CK- and strongly beta-HCG-positive. Many syncytiotrophoblastic cells with a brisk CK- and beta-HCG-positivities are also noted. The embryonal carcinoma component is metastasized to the controlateral ovary, uterus and omentum. A complete immunohistochemical analysis is recommended to properly diagnose germ cell neoplasias of the ovary both for descriptive and prognostic-therapeutic purposes. The very rare presence in the same ovarian tumor of mixed patterns as adult embryonal carcinoma and dysgerminoma with trophoblastic cells, is stressed.
authors.forename: M
authors.initials: M
authors.lastname: Martinazzi
authors.forename: G
authors.initials: G
authors.lastname: Bertoli
authors.forename: F
authors.initials: F
authors.lastname: Crivelli
authors.forename: C
authors.initials: C
authors.lastname: Zampatti
authors.forename: A
authors.initials: A
authors.lastname: Bersiga
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D004407:Dysgerminoma / Q000032:analysis / Q000473:pathology*; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000032:analysis / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000032:analysis / Q000473:pathology*; D013724:Teratoma / Q000032:analysis / Q000473:pathology* / Q000556:secondary; D014327:Trophoblasts / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
vernacular_title: Neoplasia germinale ovarica complessa: carcinoma embrionale adulto e disgerminoma con trofoblasto.