Agranulocytosis caused by dapsone therapy for granuloma annulare.
Dapsone has been suggested as a useful drug in the treatment of granuloma annulare; however, adverse reactions include a potentially life-threatening agranulocytosis. We report the case of a 50-year-old woman in whom agranulocytosis and septicemia developed after 7 weeks of therapy with dapsone for granuloma annulare. Full recovery followed cessation of this drug, but caution is advised in prescribing dapsone for relatively benign skin conditions.
Potter
M N
MN
Department of Haematology, Southmead Hospital, Bristol, U.K.
Yates
P
P
Slade
R
R
Kennedy
C T
CT
D000380:Agranulocytosis / Q000139:chemically induced*; D003622:Dapsone / Q000008:administration & dosage / Q000009:adverse effects*; D004550:Elbow; D004927:Escherichia coli Infections / Q000209:etiology; D005260:Female; D006099:Granuloma / Q000188:drug therapy*; D006801:Humans; D007717:Knee; D008875:Middle Aged; D018805:Sepsis / Q000209:etiology; D012871:Skin Diseases / Q000188:drug therapy*
D003622:Dapsone