title: Synaptic plasticity at the crayfish opener neuromuscular preparation.
abstract: The crayfish opener neuromuscular preparation exhibits most of the plasticities yet described for any synapse, including facilitation, long-term potentiation, presynaptic inhibition, and modulation. Since the presynaptic terminals and postsynaptic muscle fibers can both be intracellularly penetrated, one can now more easily examine the cellular/molecular bases for these plasticities. Data from such studies suggest that facilitation may be influenced by something other than residual free calcium and that presynaptic inhibition is produced by a conductance increase to chloride in the terminals of the excitor axon. Several drugs (ethanol, pentobarbital) have significant effects on these synaptic plasticities over concentration ranges which produce obvious behavioral effects in crayfish and mammals. Hence, this preparation should be a useful model system to determine cellular/molecular bases for various synaptic plasticities and the effects of drugs on these plasticities.
authors.affiliation: Department of Zoology, College of Pharmacy, University of Texas, Austin 78712.
authors.forename: G D
authors.initials: GD
authors.lastname: Bittner
mesh_terms: D000818:Animals; D003400:Astacoidea / Q000502:physiology*; D066298:In Vitro Techniques; D009469:Neuromuscular Junction / Q000502:physiology*; D009473:Neuronal Plasticity