title: Rheumatic syndromes and beta 2-microglobulin amyloidosis in patients receiving long-term peritoneal dialysis.
abstract: We studied 56 patients who had been receiving peritoneal dialysis for greater than 3 years, to investigate the prevalence of rheumatic diseases suggestive of beta 2-microglobulin (beta 2m) amyloid deposition. Eight patients were found to have carpal tunnel syndrome, 16 had chronic shoulder pain, 8 had subchondral bone cysts, and 13 had destructive arthropathies. Amyloid reacting with anti-beta 2m was demonstrated in the hip synovium of 1 patient. Serum beta 2m levels were elevated in all patients. These data suggest that peritoneal dialysis, like hemodialysis, may lead to the development of an arthropathy associated with beta 2m accumulation and beta 2m amyloid deposition.
authors.affiliation: Hôpital Lariboisière, Centre Viggo Petersen, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Cornélis
authors.forename: T
authors.initials: T
authors.lastname: Bardin
authors.forename: B
authors.initials: B
authors.lastname: Faller
authors.forename: C
authors.initials: C
authors.lastname: Verger
authors.forename: M
authors.initials: M
authors.lastname: Allouache
authors.forename: P
authors.initials: P
authors.lastname: Raymond
authors.forename: J
authors.initials: J
authors.lastname: Rottembourg
authors.forename: D
authors.initials: D
authors.lastname: Tourlière
authors.forename: C
authors.initials: C
authors.lastname: Benhamou
authors.forename: L H
authors.initials: LH
authors.lastname: Noel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D011446:Prospective Studies; D011859:Radiography; D012216:Rheumatic Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000097:blood
chemical_list: D000682:Amyloid; D001613:beta 2-Microglobulin