Delayed pressure urticaria, objective evaluation of a variable disease using a dermographometer and assessment of treatment using colchicine.
A randomized double-blind placebo controlled trial of colchicine in the treatment of 13 patients with delayed pressure urticaria enabled us to assess some of the variables in this disorder. We have modified a previously described method of pressure testing using a calibrated dermographometer and shown a pressure induced papular dose response curve. Assessment of disease activity was based on the number of pressure weals which occurred, the size of delayed pressure induced papules using a dermographometer calibrated at 9.75 x 10(5) pascals for five separate time periods on the back and estimations of erythrocyte sedimentation rate and the acute phase protein levels. We have been unable to show a therapeutic effect using colchicine 0.5 mg bd for I week.
Lawlor
F
F
Institute of Dermatology, St. Thomas' Hospital, London, U.K.
Black
A K
AK
Ward
A M
AM
Morris
R
R
Greaves
M W
MW
D000328:Adult; D002986:Clinical Trials as Topic; D003078:Colchicine / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011312:Pressure; D011897:Random Allocation; D012867:Skin / Q000473:pathology; D012882:Skin Tests / Q000295:instrumentation*; D014581:Urticaria / Q000188:drug therapy* / Q000473:pathology
D003078:Colchicine