Granulomonopoiesis and production of granulomonopoietic regulating factors in Hodgkin's disease and non-Hodgkin's lymphomas.
Quantitative and functional abnormalities of T and B lymphocytes and monocytes have been described in Hodgkin's disease (HD) and non-Hodgkin's lymphomas (NHL), thus making both diseases suitable models to study the interactions between lymphoid and myeloid systems. We evaluated the growth of colony-forming units of granulocytes and monocytes/macrophages (CFU-GM), as well as the colony-stimulating activity (GM-CSA) produced by monocytes and the colony-inhibiting activity (GM-CIA) released by autologous rosette-forming T-cells (Tar cells), a postthymic precursor subpopulation, in peripheral blood samples from 7 patients with HD and 5 with NHL. CFU-GM growth in HD and NHL patients was similar to that observed in controls. However, GM-CSA and GM-CIA were significantly decreased in both HD (p = 0.002 and p = 0.012, respectively) and NHL (p = 0.003 and p = 0.017, respectively) patients as compared to controls. These data suggest that cytokine-dependent mechanisms regulating normal CFU-GM proliferation are impaired in HD and NHL.
Lòpez-Karpovitch
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Department of Hematology, Instituto Nacional de la Nutrición Salvador Zubirán, Delegación Tlalpan, Mexico, D.F.
Càrdenas
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MR
Lobato-Mendizabal
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Piedras
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003115:Colony-Stimulating Factors / Q000096:biosynthesis; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006098:Granulocytes / Q000166:cytology*; D006133:Growth Substances / Q000096:biosynthesis; D006410:Hematopoiesis; D006689:Hodgkin Disease / Q000097:blood*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000097:blood*; D008264:Macrophages / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology*; D012397:Rosette Formation
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016178:Granulocyte-Macrophage Colony-Stimulating Factor