Plasma erythropoietin activity in diabetes patients, studied by determining the 59Fe incorporation in posthypoxic polycythemic mice.
The plasma erythropoietin activity in diabetes patients was studied using methods for biological testing on posthypoxic polycythemic mice, based on the incorporation of 59Fe in the newly-formed red blood cells of the animals. The data are read on an automatic scintillation gamma-counter. Considerably higher erythropoietin activity of the plasma obtained from diabetics (p less than 0.01) compared with clinically health individuals has been obtained, as well as a statistically significant difference in the percentage of 59F incorporated in the newly-formed erythrocytes of the animals treated with that plasma, compared with the animals treated with saline. A dependence has been found between the chronic hyperglycaemia and the plasma erythropoietin level.
Nikolov
V
V
Department of Physiology, Higher Medical Institute, Stara Zagora.
Kalaydjieva
V
V
Logofetov
A
A
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000150:complications; D007501:Iron / Q000097:blood*; D007504:Iron Radioisotopes; D008074:Lipoproteins / Q000097:blood; D008297:Male; D051379:Mice; D008875:Middle Aged; D011086:Polycythemia / Q000097:blood* / Q000209:etiology
D001786:Blood Glucose; D006454:Hemoglobins; D007504:Iron Radioisotopes; D008074:Lipoproteins; D004921:Erythropoietin; D007501:Iron