title: [Ways and means for prolonging the action of drugs (the status of the problem and the outlook)].
abstract: The modern approaches and concrete variants of the up-to-date means of prolongation of the biological effects of medicinal compounds having high tropic target-structures in the organism (pharmacodynamic drugs) are summarized. According to the principles of the influence on biodistribution, pharmacodynamics and metabolism of drugs, three main methods of prolongation: (technological (pharmaceutical), chemical and physiological are distinguished. The expediency of distinguishing a new method of prolongation--immunological is grounded. During the use of the method a drug in the complex with specific immunoglobulins of certain serological characteristics is a reversible depot-form of the preparation under in vivo conditions that provides the effect of prolongation.
authors.forename: S N
authors.initials: SN
authors.lastname: Golikov
authors.forename: G A
authors.initials: GA
authors.lastname: Gur'ianov
authors.forename: V K
authors.initials: VK
authors.lastname: Kozlov
mesh_terms: D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations; D004304:Dosage Forms; D004337:Drug Carriers; D006801:Humans; D000922:Immunotoxins / Q000494:pharmacology; D008081:Liposomes; D010599:Pharmacokinetics; D013329:Structure-Activity Relationship; D013678:Technology, Pharmaceutical / Q000639:trends
chemical_list: D003692:Delayed-Action Preparations; D004304:Dosage Forms; D004337:Drug Carriers; D000922:Immunotoxins; D008081:Liposomes
vernacular_title: Puti i sposoby prolongirovaniia deĭstviia lekarstvennykh sredstv (sostoianie voprosa i perspektivy).