Hemopoietic growth factor gene transfer.
Introduction of hemopoietic growth factor genes into hemopoietic cells using retroviral vectors or by the generation of transgenic mice has been a valuable approach in analyzing the role of these growth factors in leukemia development and in determining the pathological consequences of stimulation by excess levels of growth factors.
Metcalf
D
D
Walter and Eliza Hall Institute of Medical Research, Victoria, Australia.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D003115:Colony-Stimulating Factors / Q000235:genetics; D005796:Genes; D005822:Genetic Vectors; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000235:genetics*; D016298:Hematopoietic Cell Growth Factors; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D014162:Transfection
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016298:Hematopoietic Cell Growth Factors; D016178:Granulocyte-Macrophage Colony-Stimulating Factor