title: An in vitro method for longitudinal evaluation of toxicity of endodontic sealers.
abstract: An in vitro method for longitudinal evaluation of root canal sealers was developed and applied. A newly introduced cell culture chamber was used to evaluate the cytotoxic effects of test samples immediately after mixing and for an extended period of time thereafter. A ranking of the test materials, based on their cytotoxicity, was allowed by the method.
authors.forename: K E
authors.initials: KE
authors.lastname: Safavi
authors.forename: L S
authors.initials: LS
authors.lastname: Spångberg
authors.forename: N S
authors.initials: NS
authors.lastname: Costa
authors.forename: G
authors.initials: G
authors.lastname: Sapounas
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D015194:Diffusion Chambers, Culture; D005347:Fibroblasts / Q000187:drug effects; D066298:In Vitro Techniques; D008422:Materials Testing / Q000379:methods; D051379:Mice; D012387:Root Canal Filling Materials / Q000633:toxicity*
chemical_list: D012387:Root Canal Filling Materials