A patient with probable systemic lupus erythematosus, lupus anticoagulant and myocardial infarction.
The case history of a 31-year-old woman is described. She had a history of thrombosis; in the past there had been an arterial embolus of the left superficial femoral artery and venous thrombosis of the right leg. The patient was admitted to hospital because of fever of unknown origin. During the hospital stay the diagnosis of probable SLE was made. She died of myocardial infarction. At autopsy, thrombosis of the small arterioles of the heart was found without sclerosis of the coronary arteries. A lupus anticoagulant could be demonstrated in her blood and seems to have been the cause of this rare complication. Treatment with anticoagulants is advised for patients with LAC and a history of thrombosis.
Coenen
J L
JL
Nikkels
R E
RE
D000328:Adult; D001777:Blood Coagulation; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis; D009203:Myocardial Infarction / Q000209:etiology*; D013927:Thrombosis / Q000209:etiology