Renin expression in the kidney and brain is reciprocally controlled by captopril.
The tissue distribution of rat renin mRNA was examined. Sensitive RNase protection analyses demonstrated that renin mRNA are produced by the extra-renal tissues such as adrenal, brain, liver, lung, pituitary and testis. In response to sodium depletion and captopril treatment, the expression of mRNAs encoding rat renin were in a tissue-specific manner. The level of kidney renin mRNA remarkably increased in sodium-depleted rats treated with captopril, whereas that of brain renin mRNA definitely decreased. No significant change in the level of liver renin mRNA was observed after the same treatment. These results suggest that the expression of cerebral renin is regulated by physiological stimuli independent of its extra-cerebral expression.
Tada
M
M
Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
Fukamizu
A
A
Seo
M S
MS
Takahashi
S
S
Murakami
K
K
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002216:Captopril / Q000494:pharmacology*; D004039:Diet, Sodium-Restricted; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009928:Organ Specificity; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012083:Renin / Q000235:genetics*
D012333:RNA, Messenger; D002216:Captopril; D012083:Renin