[Clemastine metabolites in the feces and urine of the rat].
After oral application of clemastine [(1), (+)-2-(2-[1-(4-chlorophenyl)-1-phenylethoxy]-ethyl)-1-methylpyrrol idine- hydrogenfumarate], to rats (200 mg/kg) 18 phase I- and II-metabolites have been detected and isolated from urine and faeces. They are products of fission of the ether bond, of aromatic and aliphatic oxidation, respectively, of alcoholic dehydration, decarboxylation, N-oxidation, O-methylation and conjugation as phase II steps. Phenolic compounds represent-in contrast to some other diphenylmethane derivatives, especially basic benzilates (propiverine, denaverine)-the main metabolic products formed by dihydrodiol mechanism or direct oxigenation. The structure of metabolites were elucidated by MS.
Göber
B
B
Sektion Chemie, Humboldt-Universität zu Berlin.
al Mardini
M A
MA
Franke
P
P
D000818:Animals; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D002974:Clemastine / Q000378:metabolism* / Q000652:urine; D005243:Feces / Q000032:analysis*; D008297:Male; D013058:Mass Spectrometry; D011759:Pyrrolidines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet
D011759:Pyrrolidines; D002974:Clemastine
Clemastinmetaboliten aus Kot und Harn der Ratte.