Olfactory neuroblastoma.
Despite the fact that olfactory neuroblastoma is considered to be a rare malignant neoplasm of the sinonasal cavity, its frequent inclusion in the differential diagnosis of small-cell neoplasms of the nasal cavity is commonplace. Differential diagnosis of small round tumors solely on the basis of a light-microscopic examination of a hematoxylin and eosin stain often can be impossible. However, immunohistochemical stains such as NSE, S-100, and chromogranin immunostain can be very helpful in diagnosing olfactory neuroblastoma. If special stains are noncontributory, the diagnosis may hinge on supporting evidence from a series of electron micrographs of a properly selected and prepared tumor.
Durham
J C
JC
D006801:Humans; D007150:Immunohistochemistry; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology*; D009669:Nose Neoplasms / Q000473:pathology*; D009831:Olfactory Mucosa