[The action of strophanthin K and beta-acetyldigoxin in vitro on the energy transformation by the contractile protein system of the normal cardiomyocyte].
It was shown in experiments on myocardial fiber bundles (MGFB) from normal heart that strophantin K and beta-acetildigoxin in vitro in concentration of 10(-6) M sharply increased the value of force generated by contractile protein system and its ability to perform work. In this case strophantin K significantly increased energy transformation efficiency. It was concluded that in myocardial contractile protein system a regulator of qualitative and quantitative energy transformation is functioning (a kind of economizer).
Karsanov
N V
NV
Macharashvili
T N
TN
Magaldadze
V A
VA
D000113:Acetyldigoxins / Q000494:pharmacology*; D000818:Animals; D004077:Digoxin / Q000031:analogs & derivatives*; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D009124:Muscle Proteins / Q000187:drug effects* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits; D012016:Reference Values; D013328:Strophanthins / Q000494:pharmacology*; D013816:Thermodynamics
D000113:Acetyldigoxins; D009124:Muscle Proteins; D013328:Strophanthins; D004077:Digoxin; C029082:strophanthin K
Deĭstvie strofantina K i beta-atsetildigoksina in vitro na preobrazovanie énergii sistemoĭ kontraktil'nykh belkov normal'nogo kardiomiotsita.