title: Methodologic issues in the design of primary prevention trials.
authors.affiliation: Department of Medicine, Harvard Medical School, Boston, Massachusetts.
authors.forename: J E
authors.initials: JE
authors.lastname: Buring
authors.forename: C H
authors.initials: CH
authors.lastname: Hennekens
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002986:Clinical Trials as Topic; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000517:prevention & control*; D010349:Patient Compliance; D011897:Random Allocation; D012307:Risk Factors; D011795:Surveys and Questionnaires