Karnamicin, a complex of new antifungal antibiotics. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.
A complex of new antifungal antibiotics designated karnamicin was isolated from the cultured broth of Saccharothrix aerocolonigenes No. N806-4. Fifteen components have so far been isolated from the complex; the major component karnamicin B2 was identified by X-ray crystallography to be a novel molecule unrelated to known antibiotics. All components of karnamicin exhibited a rather broad spectrum of activity against fungi and yeasts with MICs ranging from 3.1 to 50 micrograms/ml.
Nishio
M
M
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
Tomatsu
K
K
Konishi
M
M
Tomita
K
K
Oki
T
T
Kawaguchi
H
H
Clardy
J
J
D000192:Actinomycetales / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology / Q000648:ultrastructure; D000818:Animals; D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005285:Fermentation; D005658:Fungi / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D011725:Pyridines / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013171:Spores, Bacterial; D013844:Thiazoles / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology
D000935:Antifungal Agents; D011725:Pyridines; D013844:Thiazoles; C060115:karnamicin