[Effect of clonidine on oro-cecal transit time in normal man].
The aim of our study was to explore the effect of clonidine on the mouth to caecum transit time in healthy man. Hydrogen-breath test, using lactulose 10 g, was carried out in 10 healthy male volunteers, in double-blind conditions and in random sequences of medications, placebo or clonidine (0.3 mg per os). Clonidine increased the mouth to caecum transit time significantly (p = 0.013): from 85 +/- 12 min. (with placebo) to 139 +/- 16 min. (mean +/- SE). This study suggests that the antidiarrheal action of clonidine is due, at least in part, to effect on motility of the proximal gut.
Baumer
P
P
Service de Gastroentérologie, Hôpital Rothschild, Paris.
Danays
T
T
Lion
L
L
Cosnes
J
J
Gendre
J P
JP
Le Quintrec
Y
Y
D000328:Adult; D001944:Breath Tests; D002986:Clinical Trials as Topic; D003000:Clonidine / Q000494:pharmacology*; D004311:Double-Blind Method; D004947:Esophagus / Q000187:drug effects / Q000502:physiology*; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D006859:Hydrogen / Q000032:analysis; D007792:Lactulose; D008297:Male; D010528:Peristalsis / Q000187:drug effects; D011897:Random Allocation
D007792:Lactulose; D006859:Hydrogen; D003000:Clonidine
Effet de la clonidine sur le temps de transit oro-caecal chez l'homme sain.