Delivery of novel therapeutic agents in tumors: physiological barriers and strategies.
Jain
R K
RK
Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213-3890.
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D001692:Biological Transport; D002199:Capillary Permeability; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000628:therapy*; D012039:Regional Blood Flow; D014018:Tissue Distribution
D000970:Antineoplastic Agents