title: A large trial of intravenous Conray 325 and Niopam 300 to assess immediate and delayed reactions.
abstract: The trial was designed as an investigation into the incidence of both immediate and delayed reactions to the intravenous administration of Conray 325 (sodium iothalamate) (844 patients) and Niopam 300 (iopamidol) (855 patients) for urographic examination. Information was obtained from questionnaires returned by patients about a week after their examination, with a response rate of 81%. Significant differences were found in the incidences of both types of reactions to the two media with respect to nausea and vomiting, arm pain, and taste in the mouth, which was commoner in patients receiving Conray 325, whereas the incidence of delayed skin rashes and parotid swelling was commoner with Niopam 300. The occurrence of a flu-like illness, so-called "iodism", was found to be equal for the two contrast media.
authors.affiliation: Department of Radiology, City Hospital, Nottingham.
authors.forename: M
authors.initials: M
authors.lastname: McCullough
authors.forename: P
authors.initials: P
authors.lastname: Davies
authors.forename: R
authors.initials: R
authors.lastname: Richardson
mesh_terms: D002986:Clinical Trials as Topic; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007479:Iopamidol / Q000008:administration & dosage / Q000009:adverse effects*; D007483:Iothalamic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009325:Nausea / Q000209:etiology; D010146:Pain / Q000209:etiology; D011897:Random Allocation; D013997:Time Factors; D014567:Urography / Q000379:methods*; D014839:Vomiting / Q000209:etiology
chemical_list: D007483:Iothalamic Acid; D007479:Iopamidol