title: Simultaneous technetium-99m MIBI angiography and myocardial perfusion imaging.
abstract: Resting first-pass radionuclide angiography (FPRNA) was performed with the myocardial perfusion agent technetium-99m MIBI. In 27 patients, it was compared with technetium-99m diethylenetriamine pentaacetic acid FPRNA. A significant correlation was present in left (r = 0.93, p less than 0.001) as well as right (r = 0.92, p less than 0.001) ventricular ejection fraction measured with both radiopharmaceuticals. In 13 patients, MIBI derived segmental wall motion was compared with contrast ventriculography. A high correlation was present (p less than 0.001), and qualitative agreement was found in 38/52 segments. In 19 patients with myocardial infarction a significant correlation was present between MIBI segmental wall motion and perfusion scores (p less than 0.001). In ten patients with a history of myocardial infarction, 18 myocardial segments demonstrated diseased coronary vessels and impaired wall motion at contrast angiography. These segments were all identified by the MIBI wall motion and perfusion study. We conclude that MIBI is a promising agent for simultaneous evaluation of cardiac function and myocardial perfusion at rest.
authors.affiliation: Department of Radiology, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance.
authors.forename: G Y
authors.initials: GY
authors.lastname: Baillet
authors.forename: I G
authors.initials: IG
authors.lastname: Mena
authors.forename: J H
authors.initials: JH
authors.lastname: Kuperus
authors.forename: J M
authors.initials: JM
authors.lastname: Robertson
authors.forename: W J
authors.initials: WJ
authors.lastname: French
mesh_terms: D000792:Angiography / Q000379:methods*; D009202:Cardiomyopathies / Q000000981:diagnostic imaging; D003287:Contrast Media; D017023:Coronary Angiography; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D009570:Nitriles; D009942:Organometallic Compounds; D004369:Pentetic Acid; D013318:Stroke Volume; D013667:Technetium; D016284:Technetium Tc 99m Pentetate; D017256:Technetium Tc 99m Sestamibi; D014055:Tomography, Emission-Computed
chemical_list: D003287:Contrast Media; D009570:Nitriles; D009942:Organometallic Compounds; D013667:Technetium; D004369:Pentetic Acid; D017256:Technetium Tc 99m Sestamibi; D016284:Technetium Tc 99m Pentetate