[The effect of finoptin on the accumulation of doxorubicin in leukemia P388 cells with induced resistance to the antibiotic].
Using male mice BDF1, it has been shown that the retention period of doxorubicin (DOX) is shorter in the leukemia P 388 cells with induced antibiotic resistance (P 388/DOX) as compared to the P 388 cells, sensitive to DOX. Administration of finoptin (FP) to animals leads to the increase of DOX concentration in the leukemia P 388/DOX cells during 240 min observation. FP promotes the therapeutic effect of DOX on mice bearing leukemia P 388/DOX. It can be suggested that the mechanism of FP action is the damaged DOX elimination from cells with induced resistance, since FP doesn't change the period of antibiotic circulation in the murine blood plasma.
Moroz
L V
LV
Donenko
F V
FV
Borovkova
N B
NB
Sitdikova
S M
SM
D000818:Animals; D004317:Doxorubicin / Q000032:analysis / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics*; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D004354:Drug Screening Assays, Antitumor; D004359:Drug Therapy, Combination; D007941:Leukemia P388 / Q000188:drug therapy* / Q000378:metabolism; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D013997:Time Factors; D014700:Verapamil / Q000627:therapeutic use*
D004317:Doxorubicin; D014700:Verapamil
Vliianie finoptina na nakoplenie doksorubitsina v kletkakh leĭkoza P388 s indutsirovannoĭ ustoĭchivost'iu k antibiotiku.