[Hypotensive and hemodynamic effects of guanfacine in arterial hypertension].
The therapeutic efficacy of guanfacine was investigated in a group of 32 hypertensive patients. Guanfacine caused a marked decrease in total peripheral vascular resistance (by 19.8%, p less than 0.001) and, hence, in blood pressure (by 19.4%), p less than 0.001). A slight reduction in the heart rate (by 9.8%, p less than 0.01) was compensated by an increase in stroke volume (by 11.8%, p less than 0.05) so that cardiac output remained constant or was even slightly raised. After 4 weeks of treatment there was a regression of the left ventricular wall thickness and mass (by 7.43 +/- 2.44 g, p less than 0.05). Guanfacine monotherapy was effective in 75% of patients with moderate hypertension (using low doses 1-3 mg/day). In severe hypertensive disease a satisfactory therapeutic response was mostly achieved by a combination of Guanfacine (3-5 mg/day) with a beta-blocker, diuretic or vasodilator. Guanfacine is a promising agent in the long-term treatment of stable hypertension, particularly in patients, whom diuretics or beta-blockers are contraindicated.
Erina
E V
EV
Beliakova
E V
EV
Charyev
Kh Z
KhZ
Panfilov
V V
VV
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D016316:Guanfacine; D006146:Guanidines / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D010648:Phenylacetates / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D006146:Guanidines; D010648:Phenylacetates; D016316:Guanfacine
Gipotenzivnyĭ i gemodinamicheskie effekty guanfatsina pri arterial'noĭ gipertonii.