Increased accumulation of N-isopropyl-p-(123I)-iodoamphetamine in two cases with mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS).
We present two cases with mitochondrial encephalopathy with lactic acidosis and strokelike episodes (MELAS), which showed both increased and decreased accumulation of N-isopropyl-p-(123I)-iodoamphetamine (123I-IMP) in single photon emission computed tomography (SPECT). The increased accumulation of the tracer occurred, before low density appeared on conventional computed tomography, suggesting that 123I-IMP SPECT may be useful in pathophysiological study of MELAS.
Morita
K
K
Department of Nuclear Medicine, Kawasaki Medical School, Okayama, Japan.
Ono
S
S
Fukunaga
M
M
Yasuda
T
T
Higashi
Y
Y
Terao
A
A
Morita
R
R
D000140:Acidosis, Lactic / Q000150:complications*; D000328:Adult; D000662:Amphetamines; D001921:Brain / Q000648:ultrastructure; D001927:Brain Diseases / Q000000981:diagnostic imaging*; D002561:Cerebrovascular Disorders / Q000150:complications*; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D008931:Mitochondria, Muscle; D013702:Temporal Lobe; D015899:Tomography, Emission-Computed, Single-Photon
D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine