Molecular genetics of lymphoid tumorigenesis.
The body of this work illustrates the utility of the combined cytogenetic and molecular approach to lymphoid tumorigenesis. A number of tumor-specific translocations have proven amenable to dissection by molecular techniques. We have a firm grasp of the general principles that underlie lymphoid neoplasia; in particular, the activation of cellular oncogenes by translocation into genes of the immunoglobulin superfamily is a widespread phenomenon. However, numerous lymphopoietic malignancies are only poorly understood. These remain a challenge for the continued application of these methodologies.
Haluska
F G
FG
Tsujimoto
Y
Y
Russo
G
G
Isobe
M
M
Croce
C M
CM
D001483:Base Sequence; D002051:Burkitt Lymphoma / Q000235:genetics; D002503:Centromere; D004247:DNA / Q000235:genetics; D006801:Humans; D008223:Lymphoma / Q000235:genetics*; D008969:Molecular Sequence Data; D014178:Translocation, Genetic
D004247:DNA