title: Failure of rectal diclofenac to augment opioid analgesia after cholecystectomy.
abstract: The analgesic efficacy of a single 100-mg suppository of diclofenac sodium given after elective cholecystectomy was studied in 30 healthy patients in a double-blind randomised controlled manner. The mean 24-hour postoperative morphine consumption of the placebo group and the diclofenac group was similar (45 mg). Analysis of the cumulative hourly morphine consumption from the patient-controlled analgesia system failed to show any statistically significant differences between the groups. Peak expiratory flow rate, forced expiratory volume at 1 second and forced vital capacity decreased 24 hours after operation to less than 50% of pre-operative values in both groups. Subjective experiences of pain, nausea and drowsiness assessed by linear analogue scoring were similar in both groups.
authors.affiliation: University Department of Anaesthesia, Leicester Royal Infirmary.
authors.forename: A D
authors.initials: AD
authors.lastname: Colquhoun
authors.forename: D
authors.initials: D
authors.lastname: Fell
mesh_terms: D000285:Administration, Rectal; D000293:Adolescent; D000328:Adult; D000368:Aged; D002763:Cholecystectomy; D002986:Clinical Trials as Topic; D004008:Diclofenac / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*; D011897:Random Allocation; D013488:Suppositories
chemical_list: D013488:Suppositories; D004008:Diclofenac; D009020:Morphine