[Mechanisms of the therapeutic and damaging (side effects) actions of inhalation aerosol therapy].
Basing on the literature and original data, the authors discuss specific features of a local and resorptive action of inhaled chemotherapeutic aerosols, provide evidence for advantages of the drugs inhalation over their introduction extrapulmonarily for treatment of respiration pathology. The data are presented on potential damage of aerosols to mucociliary clearance, air-blood barrier, surfactant system. Ways of these adverse effects correction are outlined. The authors hold that inhalations used for drug resorption should not be recommended for wide application until the drugs are tested for toxicity and relevant pharmacokinetics is studied.
Pilipchuk
N S
NS
Kliachkin
L M
LM
Protsiuk
R G
RG
D000042:Absorption; D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D012138:Respiratory Therapy / Q000009:adverse effects*; D012307:Risk Factors
D000336:Aerosols; D004364:Pharmaceutical Preparations
O mekhanizmakh lechebnogo i povrezhdaiushchego (pobochnogo) deĭstviia ingaliatsionnoĭ aérol'terapii.