The impact of purposeful sharing by HLA matching in the South Eastern Organ Procurement Foundation (SEOPF).
A voluntary system was created to foster early sharing of well-matched organs between like-minded renal transplantation programs. In the two historic periods 1982-85 and 1985-86, sharing programs (Category I & II) and nonsharing programs (Category III) had similar graft survival. In the study period 1986-88, graft survival improved in Category I and II programs and was unchanged in Category III programs. Highly sensitized recipients in sharing programs had an incremental gain of 15.0%, patients receiving multiple grafts 12.6%. Grafts derived from local donors and transplants in less sensitized patients also were improved but for less obvious reasons. The implementation of this study was followed by a slight decrement in delayed graft function. It is our conclusion that early graft sharing can result in improved overall early graft survival.
Pfaff
W W
WW
South Eastern Organ Procurement Foundation (SEOPF), Richmond, Virginia 23226.
Sanfilippo
F
F
Lucas
B A
BA
Vaughn
W K
WK
D006085:Graft Survival; D006680:HLA Antigens / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D015144:Southeastern United States; D009927:Tissue and Organ Procurement / Q000458:organization & administration*
D006680:HLA Antigens