[Osteocalcin or bone GLA-protein].
Osteocalcin or GLA bone protein, the most abundant of non-collagen proteins in bone, is produced only by osteoblasts. Synthesis is enhanced by the active form of vitamin D. Most of the osteocalcin produced combines with hydroxyapatite crystals, but a small proportion is circulated in the bloodstream and eliminated by the kidneys. Because bone resorption and bone formation are closely linked, serum osteocalcin is a specific and reliable marker of bone tissue activity.
Mariani
R
R
Altarès
S
S
Bérard
E
E
D002135:Calcium-Binding Proteins / Q000096:biosynthesis / Q000097:blood / Q000502:physiology; D006801:Humans; D015675:Osteocalcin
D002135:Calcium-Binding Proteins; D015675:Osteocalcin
L'ostéocalcine ou GLA-protéine osseuse.