title: [Methodologic principles for the prognosis of chronic toxicity of substances based on results of short-term trials].
abstract: One of the most important concerns of air-hygienic research is the determination of the threshold concentration for the influence of air-contaminating substances. The threshold concentrations are the basis of the air-hygienic norms. The experimental determination of the threshold concentration with chronical influence is expensive and needs a lot of time. A new method of extrapolation of the toxicity values obtained from subacute experiments is described. Different from other methods of extrapolation the biological qualities of the substances as well as the peculiarities of the toxic process are taken into consideration. In addition, evidence on the optimal duration of the chronical experiment can be derived. The extrapolation method described is not applicable to substances with extremely intensive cumulation.
authors.forename: G N
authors.initials: GN
authors.lastname: Sidorenko
authors.forename: Z I
authors.initials: ZI
authors.lastname: Zoldakova
authors.forename: G N
authors.initials: GN
authors.lastname: Krasovskij
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000397:Air Pollution / Q000517:prevention & control*; D000818:Animals; D005859:Germany, East; D006801:Humans; D008452:Maximum Allowable Concentration; D011379:Prognosis; D012307:Risk Factors
chemical_list: D000393:Air Pollutants
vernacular_title: Methodische Grundlagen für die Prognose der chronischen Toxizität von Stoffen anhand der Ergebnisse kurzdauernder Versuche.