title: Cellular retinol-binding protein in mucosa, in benign and malignant non-squamous cell tumours of the head and neck.
abstract: The measurement and localisation of cellular retinol-binding protein (CRBP), in samples of normal oral mucosa, larynx papilloma and malignant lymphoma of the oropharynx, was performed with a radioimmunoassay and immunolocalisation techniques. As compared with CRBP concentration in normal mucosa, those in laryngeal papilloma were significantly higher, but those of malignant lymphoma were similar. CRBP concentrations were highest in maturing keratinocytes within the prickle cell layers of normal mucosa and in laryngeal papillomas, as estimated on the basis of immunoreactivity to CRBP. The retinyl palmitate concentrations in extracts of oral mucosa correlated to the retinol concentrations, both in plasma and mucosal extracts, but not to the CRBP content in mucosal extracts. The immunolocalisation of a cellular retinoic acid-binding protein (CRABP) like antigen in normal oral mucosa showed much the same picture with strongest staining of the maturing keratinocytes of the prickle cell layers.
authors.affiliation: Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Wahlberg
authors.forename: G
authors.initials: G
authors.lastname: Fex
authors.forename: J
authors.initials: J
authors.lastname: Wennerberg
authors.forename: R
authors.initials: R
authors.lastname: Willén
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007822:Laryngeal Neoplasms / Q000378:metabolism*; D008223:Lymphoma / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000378:metabolism*; D009959:Oropharyngeal Neoplasms / Q000378:metabolism*; D010212:Papilloma / Q000378:metabolism*; D010610:Pharyngeal Neoplasms / Q000378:metabolism*; D011863:Radioimmunoassay; D012177:Retinol-Binding Proteins / Q000032:analysis*; D054840:Retinol-Binding Proteins, Cellular; D054839:Retinol-Binding Proteins, Plasma
chemical_list: D012177:Retinol-Binding Proteins; D054840:Retinol-Binding Proteins, Cellular; D054839:Retinol-Binding Proteins, Plasma