Intra-renal localization of b2-microglobulin (b2-m) in renal transplant material. An immunohistochemical study.
The distribution of b2-m immunoreactivity in biopsy material (paraffin sections) of 34 patients with renal transplantation was examined. b2-m was present along the glomerular capillary walls and in cytoplasm of the epithelial cells of convoluted tubules and mainly towards their basement membranes in 15 out of 17 with acute rejection, in 5 out of 8 with chronic rejection and only one case of normal donor. The more frequent detection and the more intense staining of b2-m in acute kidney rejection are discussed.
Nakopoulou
L
L
Department of Pathology, Medical School, Athens University, Greece.
Christodoulides
C
C
Stefanaki
K
K
Nikolaou
E
E
Davaris
P
P
D006084:Graft Rejection; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000378:metabolism*; D016030:Kidney Transplantation; D001613:beta 2-Microglobulin / Q000378:metabolism*
D001613:beta 2-Microglobulin