Influence of albumin and non-esterified fatty acids on serum prostacyclin binding in pregnancy.
We investigated the etiology of the previously documented decrease in serum prostocyclin binding during pregnancy. Addition of albumin to the serum of pregnant women failed to raise binding to non-pregnant levels. Pregnancy serum bound significantly more prostacyclin following the removal of non-esterified fatty acids and the addition of fatty acid free albumin resulted in a rise in binding to non-pregnant levels. We conclude that serum protein prostacyclin binding is affected by both albumin concentration and non-esterified fatty acids.
O'Brien
W F
WF
Dept. of Obstetrics and Gynecology, Univ. of South Florida, College of Medicine, Tampa 33612.
Saba
H I
HI
Knuppel
R A
RA
Benoit
R
R
Bruce
A
A
D001798:Blood Proteins / Q000378:metabolism; D011464:Epoprostenol / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism / Q000494:pharmacology*
D001798:Blood Proteins; D005230:Fatty Acids, Nonesterified; D012709:Serum Albumin; D011464:Epoprostenol