[Studies on the effect of Krynica mineral water from the "Zuber" spring on alcohol-damaged gastric mucosa in rats].
The study was performed to investigate the protective effect of mineral water "Zuber", "Zuber" with "Jan" and an antacid on the alcohol induced gastric mucosal injury in rats. It was shown that Alugastrin, a hyperosmotic liquid antacid, protects rat gastric mucosa against alcohol. In opposite, a hyperosmotic and alkaline mineral water "Zuber" increases a vulnerability of the gastric mucosa and worsen the damaging effect of alcohol on it. Izoosmotic mixture of mineral waters "Zuber" and "Jan", similarly to a physiologic saline, do not protect rat gastric mucosa. The study show that mineral waters "Zuber" and "Zuber" with "Jan" have a short-lasting neutralizing effect on the gastric HCl and in opposite to antacids have not protective properties on gastric mucosa.
Mach
T
T
Bogdał
J
J
Stachura
J
J
Kirchmayer
S
S
Konturek
J
J
Tetnowski
J
J
D000536:Aluminum Hydroxide; D000818:Animals; D000863:Antacids / Q000627:therapeutic use*; D002254:Carbonates; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D005753:Gastric Mucosa / Q000187:drug effects*; D005756:Gastritis / Q000628:therapy*; D005757:Gastritis, Atrophic / Q000139:chemically induced / Q000628:therapy*; D008297:Male; D008900:Mineral Waters; D051381:Rats; D011919:Rats, Inbred Strains
D000863:Antacids; D002254:Carbonates; D008900:Mineral Waters; C065656:alugastrin; D000431:Ethanol; D000536:Aluminum Hydroxide
Badania nad wpływem krynickiej wody mineralnej ze źródła "Zuber" na uszkodzona alkoholem błone śluzowa zoładka szczurów.