Chromosome error propagation and cancer.
A general characteristic of tumour cells is their unstable karyotype. It is suggested here that maintenance of the normal diploid cell depends on the presence of two copies of specific genes; a change in gene dosage of one or more of these genes, by chromosome nondisjunction or rearrangement, may trigger a general loss of accuracy in chromosome segregation at mitosis.
Holliday
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D002869:Chromosome Aberrations; D015321:Gene Rearrangement; D009369:Neoplasms / Q000235:genetics*; D009630:Nondisjunction, Genetic; D011003:Ploidies