title: Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women.
abstract: Computed tomography (CT) was used to study the association between adipose tissue localization and glucose tolerance in a sample of 52 premenopausal obese women aged 35.7 +/- 5.5 yr (mean +/- SD) and with a body fat of 45.9 +/- 5.5%. Body-fat mass and the body mass index (BMI) were significantly correlated with plasma glucose, insulin, and connecting peptide (C-peptide) areas after glucose (75 g) ingestion (.40 less than or equal to r less than or equal to .51, P less than .01). Trunk-fat accumulation and the size of fat cells in the abdomen displayed highly significant correlations with postglucose insulin levels. The C-peptide area was also positively correlated with abdominal fat cell size (r = .76, P less than .01) and was more closely associated with the sum of trunk skin folds (r = .59, P less than .001) than with the extremity skin folds (r = .29, P less than .05). Subcutaneous and deep-abdominal-fat areas measured by CT displayed comparable associations with the plasma insulin area (r = .44 and .49, respectively; P less than .001) but marked differences in the associations with glucose tolerance. Indeed, subcutaneous abdominal fat was not significantly correlated with the glucose area, whereas deep abdominal fat showed a significant correlation (r = .57, P less than .001) with the glucose area. Midthigh fat deposition measured by CT was not, however, correlated with plasma glucose, insulin, or C-peptide areas.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Physical Activity Sciences Laboratory, Laval University, Quebec, Canada.
authors.forename: J P
authors.initials: JP
authors.lastname: Després
authors.forename: A
authors.initials: A
authors.lastname: Nadeau
authors.forename: A
authors.initials: A
authors.lastname: Tremblay
authors.forename: M
authors.initials: M
authors.lastname: Ferland
authors.forename: S
authors.initials: S
authors.lastname: Moorjani
authors.forename: P J
authors.initials: PJ
authors.lastname: Lupien
authors.forename: G
authors.initials: G
authors.lastname: Thériault
authors.forename: S
authors.initials: S
authors.lastname: Pinault
authors.forename: C
authors.initials: C
authors.lastname: Bouchard
mesh_terms: D000005:Abdomen; D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000473:pathology*; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002096:C-Peptide / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D009765:Obesity / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D011859:Radiography
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin