[Evaluation of the histopathologic effects following subconjunctival injection of corticoids in immediate- and retard-action forms].
We comparatively studied histopathologic impairments following subconjonctival injections of long and short acting corticosteroids and saline. 44 conjunctival biopsies were performed in the site of injection. The tissues were evaluated by light and electron microscopy. The histopathologic findings, following saline subconjonctival injection were very slight. On the other hand, histopathologic findings following corticoids injection, and particularly long action products, were remarkable. We noted crystalline deposits inclusions of drug particles in fibroblast and macrophages, loss of collagen definition and degenerative changes of these phagocytosing cells, with release of their cytoplasmic contents. Our findings are according with previous studies about long acting corticosteroids, supporting their relative histologic toxicity, by local way of administration.
Noye
J F
JF
Service d'Ophtalmologie, Hôpital Centrál, Nancy.
George
J L
JL
Aymard
B
B
Berrod
J P
JP
Guedenet
J C
JC
Raspiller
A
A
D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D003228:Conjunctiva / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D003692:Delayed-Action Preparations; D005938:Glucocorticoids / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007267:Injections; D008854:Microscopy, Electron
D003692:Delayed-Action Preparations; D005938:Glucocorticoids; C018230:betamethasone acetate phosphate; C028994:betamethasone sodium phosphate; D001623:Betamethasone
Evaluation des effets histopathologiques secondaires aux injections sous-conjonctivales de corticoïdes en formes immédiates et retard.