Mesangiolytic glomerulopathy in a bone marrow allograft recipient.
A boy with null-cell leukemia received a bone marrow allograft after preparation with chemotherapy and total body irradiation. Cyclosporine A was not administered following transplantation. Renal biopsy performed 6 months after transplantation because of unexplained deterioration of renal function revealed diffuse mesangiolysis and glomerular sclerosis. The significance of this finding is discussed with reference to similar, recently reported cases.
Iskandar
S S
SS
Department of Pathology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
Browning
M C
MC
Lorentz
W B
WB
D016026:Bone Marrow Transplantation; D002648:Child; D005921:Glomerulonephritis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology* / Q000648:ultrastructure; D015470:Leukemia, Myeloid, Acute / Q000601:surgery*; D008297:Male; D008854:Microscopy, Electron; D011183:Postoperative Complications / Q000209:etiology* / Q000473:pathology; D014184:Transplantation, Homologous