[Experimental studies on bile acid metabolism after extended hepatectomy, with special reference to mechanism of an early increase of bile acids in the serum].
The purpose of this study was to evaluate an early increase of bile acids in the serum after the extended hepatectomy, namely 84% hepatectomy in normal dogs and 70% hepatectomy in dimethylnitrosamine-induced cirrhotic dogs. Many dogs died due to hepatic insufficiency caused by severe intrahepatic cholestasis and functional disturbance of the remnant liver within 7 days after extended hepatectomy. Serum total bile acids increased with the peak at 12 hours after surgery, accompanied by an increase of taurine-conjugated bile acids, and each concentration of them was higher in the hepatic vein than in the portal vein. These results suggested that an early increase of bile acids in the serum after the extended hepatectomy resulted from the reflux to systemic circulation from the remnant liver due to disturbance of bile excretion into biliary tract and the decrease of hepatic functional mass with decrease of blood perfusion.
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D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood*; D004285:Dogs; D005260:Female; D006498:Hepatectomy / Q000379:methods; D008106:Liver Cirrhosis, Experimental / Q000503:physiopathology / Q000601:surgery; D008297:Male; D011184:Postoperative Period
D001647:Bile Acids and Salts