[Effects of FeSO4 on electrical and mechanical activity of guinea pig papillary muscles].
FeSO4 0.1-0.7 mmol/L shortened the action potential duration, decreased the action potential amplitude (APA) and maximal upstroke velocity of 0 phase (Vmax), and reduced the contractile force of myocardium in a concentration-dependent manner. FeSO4 0.2 mmol/L depressed the APA and Vmax of papillary muscles in Tyrode's solution containing MnCl2 3 mmol/L, and reduced the APA, Vmax and duration of slow action potentials in potassium-depolarized papillary muscles. These results suggest that Fe2+ may inhibit the transmembrane movement of Ca2+ and Na+ in myocardial cells. This may be one of the mechanisms of heart failure and circulatory collapse in acute iron poisoning.
Luo
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D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D005260:Female; D005296:Ferrous Compounds / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010210:Papillary Muscles / Q000187:drug effects*
D005296:Ferrous Compounds; C020748:ferrous sulfate