Does a selective 5-hydroxytryptamine antagonist (ICI 169, 369) lower blood pressure in hypertensive patients?
1. The effect of single doses (10, 30 and 50 mg) of a selective 5-HT2 receptor antagonist, ICI 169, 369, on blood pressure, heart rate and the electrocardiogram was studied using a double-blind, placebo-controlled, within subject design in hypertensive patients. 2. ICI 169, 369 did not reduce blood pressure or increase QT interval as has been reported with ketanserin. This suggests that it is the other properties of ketanserin which are responsible for its antihypertensive effect. 3. Plasma concentrations of AUC for ICI 169, 369 were low. This is consistent with low bioavailability due to extensive first pass metabolism. 4. ICI 169, 369 was well tolerated and none of the symptoms reported by the patients was thought to be drug related.
Scott
A K
AK
Department of Medicine and Therapeutics, University of Aberdeen.
Roy-Chaudhury
P
P
Webster
J
J
Petrie
J C
JC
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011804:Quinolines / Q000009:adverse effects / Q000627:therapeutic use*; D011897:Random Allocation; D012702:Serotonin Antagonists / Q000009:adverse effects / Q000627:therapeutic use*
D011804:Quinolines; D012702:Serotonin Antagonists; C054363:2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline