[Continuous ambulatory monitoring of the therapeutic effect of captopril, 50 mg/day, in mild and moderate essential arterial hypertension].
The therapeutic effect of captopril in treating mild to moderate arterial hypertension has been evaluated in 20 patients. During 15 days patients underwent a washout period. Patients then received a single dose of 50 mg of captopril by mouth per day during 4 weeks. Before and after treatment, blood pressure (BP) was continuously monitored during 24 hours by a Pressure Holter (Spacelabs Monitor 5300). Mean baseline 24 hour record BP was 152 +/- 24/94 +/- 17 mmHg and after one month treatment both diastolic and systolic pressures significantly decreased to 145 +/- 16/87 +/- 13 mmHg (p less than 0.001). No adverse effects were reported during treatment.
Hergueta
G
G
Estruch
J
J
D000328:Adult; D000368:Aged; D002216:Captopril / Q000627:therapeutic use*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*
D002216:Captopril
Monitorización continua ambulatoria del efecto terapéutico del captopril, 50 mg/día, en la hipertensión arterial esencial leve y moderada.