title: Thymopentin (TP-5) in the treatment of rheumatoid arthritis.
abstract: A randomized control trial of TP-5 in rheumatoid arthritis is reported. In a multicentre study, 76 patients were treated with TP-5 50 mg or placebo three times a week for 3 weeks as a slow intravenous injection, and followed for 7 weeks. Clinical parameters such as the Ritchie index and sum score of swollen joints improved significantly on TP-5 compared to placebo. Laboratory parameters did not change but an increased skin test score to common recall antigens was observed. Toxicity was minimal. TP-5 is a potentially useful agent in the treatment of rheumatoid arthritis, although further studies are required to determine the optimal treatment regimen.
authors.affiliation: Royal National Hospital for Rhematic Diseases, University of Bath, UK.
authors.forename: B K
authors.initials: BK
authors.lastname: Kantharia
authors.forename: N J
authors.initials: NJ
authors.lastname: Goulding
authors.forename: N D
authors.initials: ND
authors.lastname: Hall
authors.forename: J
authors.initials: J
authors.lastname: Davies
authors.forename: P J
authors.initials: PJ
authors.lastname: Maddison
authors.forename: P A
authors.initials: PA
authors.lastname: Bacon
authors.forename: M
authors.initials: M
authors.lastname: Farr
authors.forename: J A
authors.initials: JA
authors.lastname: Wojtulewski
authors.forename: K M
authors.initials: KM
authors.lastname: Englehart
authors.forename: S P
authors.initials: SP
authors.lastname: Liyanage
mesh_terms: D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D010446:Peptide Fragments / Q000009:adverse effects / Q000627:therapeutic use*; D012720:Severity of Illness Index; D012882:Skin Tests; D013601:T-Lymphocytes / Q000145:classification; D016305:Thymopentin; D013946:Thymopoietins / Q000009:adverse effects / Q000627:therapeutic use*; D013951:Thymus Hormones / Q000627:therapeutic use*
chemical_list: D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; D016305:Thymopentin