title: [Current aspects of bacterial resistance to antibiotics].
abstract: New aspects of the evolution of bacterial antibiotic resistance are discussed. Dissemination of antibiotic resistance appears to be unlimited since resistance genes from Gram-positive cocci have been detected in Gram negative bacteria. This suggests the occurrence of heterogramic genetic transfers between these phylogenetically distinct organisms. New characters of resistance to beta-lactam antibiotics in enterobacteria result from the apparition of mutant of the TEM-1 and TEM-2 penicillinases. Mutations that confer the capacity to hydrolyze the third generation cephalosporins are located in the active site of the enzymes.
authors.affiliation: Unité des Agents Antibactériens, CNRS UA271, Institut Pasteur, Paris.
authors.forename: A
authors.initials: A
authors.lastname: Brisson-Noel
authors.forename: P
authors.initials: P
authors.lastname: Trieu-Cuot
authors.forename: W
authors.initials: W
authors.lastname: Sougakoff
authors.forename: P
authors.initials: P
authors.lastname: Courvalin
mesh_terms: D003227:Conjugation, Genetic; D004352:Drug Resistance, Microbial; D005798:Genes, Bacterial; D006090:Gram-Negative Bacteria / Q000235:genetics*; D006094:Gram-Positive Bacteria / Q000235:genetics*; D006801:Humans; D009154:Mutation; D010641:Phenotype; D010957:Plasmids; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D001618:beta-Lactamases
vernacular_title: Aspects actuels de la résistance bactérienne aux antibiotiques.