Intratubular germ cell neoplasia in testicular teratomas and epidermoid cysts. Correlation with prognosis and possible biologic significance.
The clinicopathologic features of 4 testicular teratomas in infants, 13 testicular epidermoid cysts in adults, and 8 pure teratomas in adults were compared. Intratubular germ cell neoplasia (ITGCN, carcinoma in situ) was observed in 88% of the teratomas in adults; 63% of the patients in this group had metastases and 37% died. No ITGCN was observed in infant testes with teratomas or adult testes with epidermoid cysts; all of the neoplasms in the latter two groups behaved as benign tumors. ITGCN is associated with malignant potential (P = 0.0004; Fisher's exact test). These tumors comprise a spectrum of clinicopathologic entities that probably reflect differences in pathogenesis.
Manivel
J C
JC
Department of Laboratory Medicine, University of Minnesota Hospital, Minneapolis.
Reinberg
Y
Y
Niehans
G A
GA
Fraley
E E
EE
D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology* / Q000556:secondary; D004814:Epidermal Cyst / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D011379:Prognosis; D013724:Teratoma / Q000473:pathology*; D013736:Testicular Neoplasms / Q000473:pathology*