Bactericidal action of peptide antibiotic AS-48 against Escherichia coli K-12.
Peptide antibiotic AS-48 exerts a bactericidal mode of action on exponential cultures of Escherichia coli K-12 through a multi-hit kinetics interaction. AS-48 causes a parallel and gradual cessation of all biosynthetic pathways monitored (protein, RNA, DNA, and cell wall synthesis), the rate of incorporation of labeled precursors, the rate of O2 consumption, and cell growth. These effects have been attributed to alterations of cytoplasmic membrane functions.
Gálvez
A
A
Departamento de Microbiología, Facultad de Ciencias, Universidad de Granada, Spain.
Valdivia
E
E
Martínez
M
M
Maqueda
M
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects
D000900:Anti-Bacterial Agents