title: [The effect of levobunolol eyedrops on trabecular outflow of aqueous humor in chronic simple glaucoma].
abstract: The present paper reports a double-blind, cross-over, randomized study in which 31 patients (62 eyes) suffering from open-angle glaucoma were included. These patients were treated for one year with 0.5% levobunolol and 0.5% timolol ophthalmic solutions and followed up. Tonographic examinations of outflow facility showed a statistically significant increase following topical applications of 0.5% levobunolol, while there was little change with 0.5% timolol. The difference in the effect of outflow facility due to instillations of 0.5% levobunolol and 0.5% timolol can be explained by the different pharmacokinetic profiles of the two beta-blocker solutions in topical ocular application.
authors.affiliation: Augenklinik des Medizinischen Institutes Cluj-Napoca.
authors.forename: M
authors.initials: M
authors.lastname: Călugăru
mesh_terms: D000328:Adult; D001082:Aqueous Humor / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D002040:Levobunolol / Q000008:administration & dosage*; D011446:Prospective Studies; D011897:Random Allocation; D013237:Stereoisomerism; D013999:Timolol / Q000008:administration & dosage; D014129:Trabecular Meshwork / Q000187:drug effects*
chemical_list: D013999:Timolol; D002040:Levobunolol
vernacular_title: Die Wirkung von Levobunolol-Augentropfen auf den trabekulären Kammerwasserabfluss beim chronischen Glaucoma simplex.