title: [A case report of thyroid papillary cancer that manifested leukocytosis and hypercalcemia after radiotherapy in bone metastasis].
abstract: Bone metastasis from a thyroid papillary cancer of a 59-year-old woman had been successfully treated with radiotherapy (6,000 rad) and iodine-131 (120 mCi). One year later, the patient developed leukocytosis (maximum 143,000/mm3) and hypercalcemia (16.0 mg/dl). A colony stimulating factor (CSF) was detectable in her plasma, and nude mice that had been given metastatic tissues similarly developed leukocytosis and hypercalcemia. Leukocytosis and hypercalcemia seemed to have been caused by the CSF produced in the bone metastasized tissues of this thyroid cancer.
authors.affiliation: Dept. of Radiology and Nuclear Medicine, Kyoto Univ. School of Med.
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Endo
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
authors.forename: K
authors.initials: K
authors.lastname: Kasagi
authors.forename: I
authors.initials: I
authors.lastname: Yamamoto
authors.forename: J
authors.initials: J
authors.lastname: Konishi
authors.forename: M
authors.initials: M
authors.lastname: Abe
authors.forename: Y
authors.initials: Y
authors.lastname: Shimizu
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging / Q000556:secondary*; D003115:Colony-Stimulating Factors / Q000378:metabolism; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007964:Leukocytosis / Q000209:etiology*; D008875:Middle Aged; D011877:Radionuclide Imaging; D013964:Thyroid Neoplasms / Q000150:complications / Q000378:metabolism / Q000532:radiotherapy*
chemical_list: D003115:Colony-Stimulating Factors; D006133:Growth Substances; D007457:Iodine Radioisotopes; D016178:Granulocyte-Macrophage Colony-Stimulating Factor