title: Small area variation in prevalence of an S-antigen serotype of Plasmodium falciparum in villages of Madang, Papua New Guinea.
abstract: Cross-sectional and longitudinal village-based studies of the transmission dynamics of an S-antigen serotype of the asexual erythrocyte stages of Plasmodium falciparum have been carried out in Madang, Papua New Guinea (PNG). Sera collected from village residents were screened for circulating S-antigen of the FC27 serotype by enzyme-linked immunosorbent assay (ELISA). The prevalence of the FC27 S-antigen was found to vary between villages at a given point in time, as well as within a village over time. Residents of villages 2-5 km apart were infected with P. falciparum of different S-antigen serotypes. This study documents the periodic nature of transmission of a sub-population of P. falciparum defined by the FC27 S-antigen. The variation in a small area in the prevalence of this serotype of P. falciparum in Madang illustrates the complexities of malaria transmission which must be considered in the design of malaria vaccine trials.
authors.affiliation: Papua New Guinea Institute of Medical Research, Madang.
authors.forename: K P
authors.initials: KP
authors.lastname: Forsyth
authors.forename: R F
authors.initials: RF
authors.lastname: Anders
authors.forename: J A
authors.initials: JA
authors.lastname: Cattani
authors.forename: M P
authors.initials: MP
authors.lastname: Alpers
mesh_terms: D000818:Animals; D000940:Antigenic Variation; D000953:Antigens, Protozoan / Q000145:classification* / Q000235:genetics; D003430:Cross-Sectional Studies; D006801:Humans; D008137:Longitudinal Studies; D008288:Malaria / Q000453:epidemiology* / Q000469:parasitology; D010219:Papua New Guinea; D010963:Plasmodium falciparum / Q000235:genetics / Q000276:immunology*; D012703:Serotyping
chemical_list: D000953:Antigens, Protozoan; C047712:S-antigen, Plasmodium falciparum