Malignant myxoid liposarcoma: an immunohistochemical, electron-microscopical and cytogenetical analysis.
We discuss the morphological, immunohistochemical and electron-microscopical features of a malignant myxoid liposarcoma which appeared in the left thigh of a 52-year-old woman. The cytogenetic analysis following short-term tissue culture confirmed the existence of a nonrandom translocation t(12;16)(q13;p11). Furthermore, immunohistochemistry showed positivity for S-100 antigen and vimentin, both of which are considered to be markers for liposarcoma. The electron-microscopical study revealed a close contiguity between the tumoral cells and atypical pericytes.
López-Ginés
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C
Department of Pathology, Medical School, University of Valencia, Spain.
Navarro
S
S
Peydró-Olaya
A
A
Pellín
A
A
Llombart-Bosch
A
A
D014408:Biomarkers, Tumor / Q000032:analysis; D002881:Chromosomes, Human, Pair 12 / Q000648:ultrastructure*; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008080:Liposarcoma / Q000235:genetics / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000473:pathology*; D013848:Thigh; D014178:Translocation, Genetic; D014746:Vimentin / Q000032:analysis; D014841:von Willebrand Factor / Q000032:analysis
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D009418:S100 Proteins; D014746:Vimentin; D014841:von Willebrand Factor