[Clinical characteristics of silent myocardial ischemia and the effect of nifedipine treatment].
The characteristics of ischemic episodes in exercise test and daily activities were observed in a silent myocardial ischemia (SMI) group and an anginal group (23 patients each). 15 patients in the SMI group were treated with nifedipine. In exercise test, the time of onset of ischemia was earlier and the ischemic threshold was lower in SMI group. During daily activities, the frequency of SMI was high. The heart rate just before onset of SMI was lower than the mean heart rate in 24-hour Holter monitoring. The highest frequency of SMI was found between 5 AM and 12 noon. Postinfarction patients had a higher frequency and a longer duration of SMI than noninfarction patients. The frequency and duration of SMI decreased in the 15 patients treated with nifedipine in SMI group. It is concluded that silent ischemic episodes were frequent and occurred easily. They might be associated with poor prognosis in CAD patients. Nifedipine was effective in reducing the frequency and duration of SMI in our patients.
Huang
L
L
Zhu
S J
SJ
Xin
Q
Q
D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy / Q000503:physiopathology; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D015716:Electrocardiography, Ambulatory / Q000187:drug effects; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*
D009543:Nifedipine