title: Studies of the proliferation and differentiation of immature myeloid cells in vitro. I. Chronic myelogenous leukemia.
abstract: Immature cells prepared from chronic myelogenous leukemic patients in the chronic or blastic phase of their disease were placed into suspension culture in vitro and studied over a 2-week period. Regardless of the status of the disease, the immature cells proliferated and maintained good viability. In contrast, evolution of the disease toward blastic crisis was associated with a progressive loss in the ability of the immature cells to differentiate. Cell proliferation and differentiation were independent of added growth factors.
authors.affiliation: Roswell Park Memorial Institute, Department of Hematologic Oncology, Buffalo, NY 14263.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: X Z
authors.initials: XZ
authors.lastname: Gao
authors.forename: H D
authors.initials: HD
authors.lastname: Preisler
mesh_terms: D001752:Blast Crisis; D001773:Blood Cells / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000494:pharmacology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*
chemical_list: D003115:Colony-Stimulating Factors; D006133:Growth Substances; D007375:Interleukin-1; D016178:Granulocyte-Macrophage Colony-Stimulating Factor