Occupational exposure to organic solvents causing chronic tubulointerstitial nephritis.
We describe a patient with a history of ulcerative colitis and long-standing occupational exposure to organic solvents. Over a follow-up period of almost four years he had progression of tubulointerstitial damage documented by two kidney biopsies. We propose that long-term exposure to organic solvents can lead to the development of chronic tubulointerstitial nephritis. We describe experimental evidence that supports our conclusion.
Narvarte
J
J
Department of Internal Medicine, James A. Haley Veterans Administration Hospital, Tampa, FL 33612.
Saba
S R
SR
Ramirez
G
G
D000328:Adult; D000401:Aircraft; D002908:Chronic Disease; D006801:Humans; D006838:Hydrocarbons / Q000009:adverse effects; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D009784:Occupational Diseases / Q000139:chemically induced*; D012997:Solvents / Q000009:adverse effects*
D006838:Hydrocarbons; D012997:Solvents