[Comparative prospective randomized multicenter study of 2 dosage protocols of nitrendipine in patients with mild to moderate hypertension].
134 patients with mild to moderate hypertension received nitrendipine during 6 months in an increasing fashion. Therapeutic goal was achieved in 92% of the patients (DBP less than 95 mmHg) in which BP decreased from 168.4 +/- 13.7/105.0 +/- 1.1 to 140.9 +/- 12.7/84.4 +/- 6.6 (p less than 0.001). In patients whose BP was not controlled with a single initial doses of 20 mg/day, the degree of control was similar with 40 mg single dose and 20 mg twice a day. The most frequently encountered undesirable effects were those caused by the vasodilator action of the drug. No changes in blood glucose and plasma lipid levels were found.
Ruilope
L M
LM
Aranda
P
P
Calvo
C
C
Casado
S
S
Martínez Amenós
A
A
Oliván
J
J
Valdés
M
M
Rodicio
J L
JL
D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009568:Nitrendipine / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation
D009568:Nitrendipine
Estudio multicéntrico prospectivo randomizado comparativo de dos esquemas posológicos de nitrendipina en pacientes hipertensos leves-moderados.