Erythropoietic activity in culture media conditioned by rat mesangial cells.
Using a tissue culture technique we examined erythropoietin (EPO) producing cells in rat glomeruli. In 5 out of 6 independent glomerular cell cultures, EPO activity was found in the mesangial-cell proliferating phase, but not in the epithelial-cell proliferating phase. Therefore, mesangial cells seemed to be EPO producing cells.
Fukushima
Y
Y
Third Department of Internal Medicine, Akita University School of Medicine.
Yanagisawa
M
M
Yasuda
T
T
Nakamoto
Y
Y
Miura
A B
AB
D000818:Animals; D003470:Culture Media / Q000032:analysis*; D004921:Erythropoietin / Q000032:analysis / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D005920:Glomerular Mesangium / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains
D003470:Culture Media; D004921:Erythropoietin