title: [Immunomapping in localized bullous pemphigoid].
abstract: A 70-year-old Caucasian patient is described, who presented with a bullous dermatosis on an amputation stump. The bullous lesions had developed after practice with a Kondylen-Bettung-Münster (KBM) prosthesis. The lesions disappeared completely after prednisone therapy and replacement of the prosthesis with a Thomas splint. The patient has remained free of symptoms ever since, even though prednisone was completely withdrawn after 9 months. According to skin immunofluorescence criteria, the patient suffered from pemphigoid, rather than epidermolysis bullosa acquisita as strongly suggested by the anamnesis. In particular, the presence of linear IgG at the level of the lamina lucida of the epidermal basement membrane zone and the localization of laminin antigen at the blister floor are highly suggestive of pemphigoid.
authors.affiliation: Universitäts-Hautklinik Groningen.
authors.forename: M C
authors.initials: MC
authors.lastname: de Jong
authors.forename: S H
authors.initials: SH
authors.lastname: Kardaun
authors.forename: R A
authors.initials: RA
authors.lastname: Tupker
authors.forename: H G
authors.initials: HG
authors.lastname: Seijen
mesh_terms: D000368:Aged; D000672:Amputation Stumps; D001186:Artificial Limbs; D001485:Basement Membrane / Q000473:pathology; D003937:Diagnosis, Differential; D004820:Epidermolysis Bullosa / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007797:Laminin / Q000032:analysis*; D008297:Male; D010391:Pemphigoid, Bullous / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G; D007797:Laminin
vernacular_title: Immunomapping in lokalisiertem bullösem Pemphigoid.