Sequential half-body irradiation in lymphomatoid granulomatosis. Report of a case and an immunohistologic study.
A case is presented of a man with ulcerating skin nodules who was diagnosed by histologic and immunohistologic analysis of skin biopsy specimens as having lymphomatoid granulomatosis (LYG). Phenotypic studies showed the majority of the infiltrating cells to be activated CD4+ T-lymphocytes. The disease followed a rapidly progressive course and did not respond to treatment with cytotoxic chemotherapy. The patient developed life-threatening systemic symptoms and involvement of both upper and lower respiratory tracts. After treatment with sequential half-body irradiation he has been in complete remission for 3.5 years.
Atkinson
C H
CH
Department of Clinical Oncology, Christchurch Hospital, New Zealand.
Davis
A L
AL
Colls
B M
BM
Wolever
T H
TH
Burry
A F
AF
Hart
D N
DN
D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D008230:Lymphomatoid Granulomatosis / Q000276:immunology / Q000532:radiotherapy*; D008297:Male; D010641:Phenotype; D012074:Remission Induction; D012878:Skin Neoplasms / Q000276:immunology / Q000532:radiotherapy*; D013997:Time Factors; D014916:Whole-Body Irradiation / Q000379:methods
D000945:Antigens, Differentiation, T-Lymphocyte