Inhibition of interleukin-1 beta release from cultured human peripheral blood mononuclear cells by prednisolone.
Prednisolone, a water-soluble glucocorticoid hormone, suppressed the secretion of interleukin-1 beta from human peripheral blood mononuclear cells in culture. The prednisolone-induced suppression of the monokine release was dose-related and the half maximal response was observed at 0.1 nM.
Uehara
A
A
Department of Internal Medicine (III), Asahikawa Medical College, Hokkaido, Japan.
Kohda
H
H
Sekiya
C
C
Takasugi
Y
Y
Namiki
M
M
D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000502:physiology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D011239:Prednisolone / Q000008:administration & dosage / Q000494:pharmacology*
D007375:Interleukin-1; D008070:Lipopolysaccharides; D011239:Prednisolone