Novel class I-like molecule expressed on a murine leukemia virus-transformed cell line.
A retrovirus-induced tumor cell line, which expresses no H-2K or H-2D class I molecules, appears to express a tumor-specific transplantation antigen which induces tumor rejection in vivo and cytotoxic T lymphocyte generation in vitro without prior immunization and thus resembles class I molecules. In addition, although these tumor cells express no detectable class I molecules, they do express beta 2 microglobulin and a 55- to 60-kDa beta 2 microglobulin-associated protein. Northern analysis demonstrated that these cells express no RNA hybridizing to class I probes, suggesting that neither the tumor-specific transplantation antigen nor the beta 2 microglobulin-associated protein, if these are different, are encoded by known class I genes.
Klyczek
K K
KK
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.
Blank
K J
KJ
D000406:AKR murine leukemia virus / Q000502:physiology*; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D002472:Cell Transformation, Viral; D006084:Graft Rejection; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D012333:RNA, Messenger / Q000032:analysis; D012334:RNA, Neoplasm / Q000032:analysis; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014407:Tumor Cells, Cultured / Q000276:immunology; D001613:beta 2-Microglobulin / Q000032:analysis
D000951:Antigens, Neoplasm; D015395:Histocompatibility Antigens Class I; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D001613:beta 2-Microglobulin