Prolonged minor allograft survival in intravenously primed mice. Effect of recipient's age and of prior immunity to minor H antigens on the priming cells.
The effect of a pretransplant i.v. infusion of donor-strain spleen cells into recipient mice that were already immune to minor H antigens on the infused cells was studied. The central finding is that a preexisting state of immunity against target minor H antigens on a skin graft is sufficient to overcome the survival-prolonging effect of a pretransplant i.v. infusion of donor-strain spleen cells. Moreover, immunity directed against an irrelevant antigen on the infused cells, rather than against a target antigen on the indicator skin graft, is sufficient to cause the beneficial effect of the infusion to be greatly reduced. A further significant finding is that the ability of a pretransplant infusion of donor-strain spleen cells to prolong the survival of a minor allograft of skin declines as the recipient matures from a 6-9-week-old juvenile to a 12-16-week-old adult.
Johnson
L L
LL
Trudeau Institute, Inc., Saranac Lake, New York 12983.
D000375:Aging; D000818:Animals; D005260:Female; D006085:Graft Survival; D006182:H-Y Antigen / Q000276:immunology*; D007111:Immunity, Cellular; D007262:Infusions, Intravenous; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008912:Minor Histocompatibility Loci; D011300:Preoperative Care / Q000379:methods; D016038:Skin Transplantation; D013154:Spleen / Q000276:immunology / Q000637:transplantation
D006182:H-Y Antigen