title: AIDS-Kaposi's sarcoma-derived cells express cytokines with autocrine and paracrine growth effects.
abstract: When grown in vitro, cells from Kaposi's sarcoma lesions of AIDS patients (AIDS-KS cells) constitutively release several growth promoting activities. When inoculated into nude mice, the AIDS-KS cells induce a KS-like lesion of mouse origin. Here it is shown that the AIDS-KS cells express messenger RNA for a complex mixture of cytokines that correlate with several of the biological activities of these cells. Basic fibroblast growth factor, which is a potent angiogenic factor, and interleukin-1 messenger RNAs are expressed at very high levels and seem to account for a large proportion of the activities, since their corresponding proteins are released in biologically active form into the culture media where they induce autocrine and paracrine growth effects.
authors.affiliation: Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892.
authors.forename: B
authors.initials: B
authors.lastname: Ensoli
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: S Z
authors.initials: SZ
authors.lastname: Salahuddin
authors.forename: P
authors.initials: P
authors.lastname: Biberfeld
authors.forename: L
authors.initials: L
authors.lastname: Larsson
authors.forename: B
authors.initials: B
authors.lastname: Beaver
authors.forename: F
authors.initials: F
authors.lastname: Wong-Staal
authors.forename: R C
authors.initials: RC
authors.lastname: Gallo
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D001685:Biological Factors / Q000235:genetics*; D016207:Cytokines; D005346:Fibroblast Growth Factors / Q000235:genetics; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000302:isolation & purification; D012016:Reference Values; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured / Q000166:cytology*
chemical_list: D001685:Biological Factors; D016207:Cytokines; D007375:Interleukin-1; D012333:RNA, Messenger; D005346:Fibroblast Growth Factors