Nocardia asteroides keratitis presenting as a persistent epithelial defect.
An elderly male presented with epithelial defect which resisted all medical and therapeutic approaches until Gram stain and cultural report documented the presence of Nocardia asteroides of the offending organism. A 3-month course of chronic keratitis with persistent epithelial defect resolved in 48 h following the use of topical trimethoprim-sulfamethoxazole.
Perry
H D
HD
Division of Ophthalmology, Nassau County Medical Center, East Meadow.
Nauheim
J S
JS
Donnenfeld
E D
ED
D000368:Aged; D001431:Bacteriological Techniques; D003315:Cornea / Q000473:pathology; D004338:Drug Combinations / Q000008:administration & dosage; D004848:Epithelium / Q000473:pathology; D006801:Humans; D007262:Infusions, Intravenous; D007634:Keratitis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D008297:Male; D009617:Nocardia Infections / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D009616:Nocardia asteroides / Q000648:ultrastructure; D013420:Sulfamethoxazole / Q000008:administration & dosage; D014295:Trimethoprim / Q000008:administration & dosage; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole