title: Comparison of analgesic requirements after liver transplantation and cholecystectomy.
abstract: In a prospective study of 10 patients who underwent liver transplantation and 10 patients who underwent cholecystectomy, we analyzed the postoperative analgesic requirements and the resultant plasma morphine concentrations. Analgesia was more intense, with less medication, and the plasma morphine concentration was significantly lower in the liver transplant group than in the cholecystectomy group. This finding is most likely attributable to endogenous factors rather than to altered morphine pharmacokinetics.
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905.
authors.forename: J C
authors.initials: JC
authors.lastname: Eisenach
authors.forename: D J
authors.initials: DJ
authors.lastname: Plevak
authors.forename: R A
authors.initials: RA
authors.lastname: Van Dyke
authors.forename: P A
authors.initials: PA
authors.lastname: Southorn
authors.forename: D R
authors.initials: DR
authors.lastname: Danielson
authors.forename: R A
authors.initials: RA
authors.lastname: Krom
authors.forename: D M
authors.initials: DM
authors.lastname: Nagorney
authors.forename: S R
authors.initials: SR
authors.lastname: Rettke
mesh_terms: D000328:Adult; D001835:Body Weight; D002763:Cholecystectomy; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000097:blood; D006801:Humans; D007668:Kidney / Q000502:physiology; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D010149:Postoperative Pain / Q000188:drug therapy* / Q000378:metabolism; D011446:Prospective Studies
chemical_list: D009020:Morphine; D005283:Fentanyl