[The immunization of white rats with a covalent conjugate of sidnofen and serum albumin suppresses chronic ethanol consumption].
The influence of white rats of alcohol abuse formation of immunization by covalent conjugates of serum albumin with psychostimulant sydnophen was investigated. Immunization by conjugates where the molar sydnophen: protein ratio was 18:1-33: 1 results in significant depression of 15% ethanol consumption (in the condition of free choice between water and ethanol solution).
Ashmarin
I P
IP
Danilova
R A
RA
Mashkovskiĭ
M D
MD
Obukhova
M F
MF
Sagimbaeva
Sh K
ShK
D000437:Alcoholism / Q000276:immunology / Q000628:therapy*; D000818:Animals; D000928:Antidepressive Agents / Q000276:immunology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006241:Haptens / Q000276:immunology* / Q000627:therapeutic use; D007114:Immunization / Q000379:methods*; D008297:Male; D010069:Oxadiazoles / Q000276:immunology*; D051381:Rats; D012709:Serum Albumin / Q000276:immunology* / Q000627:therapeutic use; D013558:Sydnones / Q000276:immunology* / Q000627:therapeutic use; D013997:Time Factors
D000928:Antidepressive Agents; D006241:Haptens; D010069:Oxadiazoles; D012709:Serum Albumin; D013558:Sydnones; C013271:sydnophen
Immunizatsiia belykh krys kovalentnym kon''iugatom sidnofena s serumal'buminom podavliaet khronicheskoe potreblenie étanola.