Effect of captopril (an angiotensin-converting enzyme inhibitor) on intraocular pressure in healthy human volunteers.
The renin-angiotensin-aldosterone system is important in the regulation of body fluids. Angiotensin-converting enzyme (ACE) which forms angiotensin II from angiotensin I, is known to be present in human ocular tissue. In rabbits, some topically applied ACE inhibitors including captopril have been shown to reduce IOP with a magnitude and duration comparable to that of topical 0.5% timolol. Captopril in a 50mg single oral dose, which had a significant effect on blood pressure, had no significant effect on IOP over a 4 hour period.
Al-Sereiti
M R
MR
Department of Clinical Pharmacology, St. Bartholomew's Hospital Medical College, University of London, England.
Turner
P
P
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011674:Pulse / Q000187:drug effects; D013997:Time Factors
D002216:Captopril