Physiology and cell biology update: polypeptide growth factors and their relation to renal disease.
A number of polypeptide growth factors have been shown to act on different types of renal cells, and many are produced by the kidney itself. It is unclear whether the compensatory hypertrophy that follows the destruction of nephrons is under the control of growth factors, but they undoubtedly participate in various forms of progressive renal injury, including chronic glomerular and tubulointerstitial diseases via autocrine, paracrine, and possibly even endocrine routes. As new developments occur in this rapidly changing field, it is hoped that this knowledge can be used to ameliorate the damage, halt the progression, or enhance the recovery from a disease process in the kidney and in other tissues.
Kujubu
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DA
Department of Medicine, Center for the Health Sciences, UCLA School of Medicine 90024.
Fine
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LG
D000818:Animals; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D007674:Kidney Diseases / Q000473:pathology / Q000503:physiopathology*
D006133:Growth Substances