Effects of intramural division of gastric vagal fibers on stimulated acid production.
Transmural proximal gastric vagotomy, an experimental procedure designed to denervate the gastric fundus by intramural division of vagal fibers, was evaluated as a means of reducing stimulated gastric acid output. The procedure reduced peak acid output in response to insulin stimulation by 71 percent. Acid production was not further decreased by extramural division of vagal fibers. It also decreased parietal cell sensitivity to pentagastrin stimulation and did not interfere with emptying of a liquid meal. We have concluded that transmural proximal gastric vagotomy is technically straightforward, reliably divides fundic vagal fibers, produces a significant reduction in acid production equivalent to that produced by standard operative techniques, and does not interfere with gastric emptying.
Mulholland
M W
MW
Department of Surgery, University of Washington, Seattle.
Debas
H T
HT
D000818:Animals; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism*; D005746:Gastric Emptying; D007328:Insulin / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D014629:Vagotomy, Proximal Gastric / Q000379:methods*
D007328:Insulin; D010418:Pentagastrin