Loss of the Y chromosome associated with translocation t(6;9)(p23;q34) in a patient with acute nonlymphocytic leukemia.
A 34-year-old male with acute nonlymphocytic leukemia (ANLL) and a t(6;9)(p23;q34) is described, in whom loss of the Y chromosome had occurred in the t(6;9) clone. The leukemic blasts were relatively undifferentiated and there was no increase in marrow basophils. The unusual clonal evolution and hematologic features in this patient are compared to 27 previously documented cases with this translocation.
Bernstein
R
R
Department of Pediatrics, University of California, Irvine.
Cain
M J
MJ
Cho
J
J
D000328:Adult; D001853:Bone Marrow / Q000648:ultrastructure; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002896:Chromosomes, Human, Pair 6; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic; D014998:Y Chromosome