A highly potent insulin: des-(B26-B30)-[AspB10,TyrB25-NH2]insulin(human).
An insulin analogue that embodies two distinct structural modifications, each of which independently increases insulin activity, has been synthesized and evaluated for biological activity. The analogue, des-(B26-B30)-[AspB10,TyrB25-NH2]insulin is the most potent insulin analogue yet described; it displays an 11- to 13-fold higher activity than natural insulin. The findings are discussed with regard to the receptor-binding domains of insulin.
Schwartz
G P
GP
Department of Biochemistry, Mount Sinai School of Medicine, City University of New York, NY 10029.
Burke
G T
GT
Katsoyannis
P G
PG
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D006801:Humans; D007328:Insulin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D008024:Ligands; D008055:Lipids / Q000096:biosynthesis; D051381:Rats; D011972:Receptor, Insulin / Q000378:metabolism
D007328:Insulin; D008024:Ligands; D008055:Lipids; C061585:insulin, despentapeptide (B26-B30)-TyrNH2(B25)-; D011972:Receptor, Insulin