Comparative study of three different dosing regimens of cefotaxime for treatment of gram-negative bacteremia.
Thirty-one patients with Gram-negative bacteremia with organisms susceptible to cefotaxime (CTX) (MIC of 1 microgram/ml or less) were randomized to receive 2 g of CTX every 6, 8, or 12 hr. Five-hour susceptibility studies were performed on a bacterial pellet obtained from the patient's positive blood culture vial. Thus, patients were enrolled within hours after Gram-negative organisms were demonstrated in their blood cultures. All bacteremias were cleared although two patients had unsatisfactory responses to therapy. Trough serum bactericidal levels were 1:2 or greater in all patients. This study supports that CTX can be used at an 8- or 12-hr intervals in selected patients with Gram-negative bacteremia.
Trenholme
G M
GM
Department of Medicine, Presbyterian-St. Luke's Medical Center Chicago, Illinois 60612.
Schmitt
B A
BA
Nelson
J A
JA
Gvazdinskas
L C
LC
Harrison
B B
BB
Parkhurst
G W
GW
D000368:Aged; D000369:Aged, 80 and over; D002439:Cefotaxime / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D012477:Salmonella enteritidis / Q000187:drug effects; D018805:Sepsis / Q000188:drug therapy*; D012706:Serratia marcescens / Q000187:drug effects
D002439:Cefotaxime