title: Detection of anti-cerebral autoantibodies in schizophrenia and Alzheimer's disease.
abstract: Autoantibodies to cerebrum were investigated in the sera from schizophrenia, Alzheimer's disease and healthy subjects by indirect immunofluorescence method. Four patterns of staining were observed: type A (neuronal cell), type B (blood vessel), type C (nucleus) and type D (glia and miscellaneous cell). Among rat, guinea pig and rabbit cerebrum, rabbit cerebrum proved best (low non-specific binding and high sensitivity) for the detection of circulating autoantibodies to cerebrum. With schizophrenia, 13 out of 46 cases (28.3%) were positive for autoantibodies to neuronal cells and 6/13 of those were not absorbed by liver acetone powder. With Alzheimer's disease, 25/63 (39.7%) were positive for autoantibodies to neuronal cells and 6/25 were not absorbed by liver acetone powder.
authors.affiliation: Sohgo Biomedical Laboratories, Saitama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sugiura
authors.forename: Y
authors.initials: Y
authors.lastname: Yokoi
authors.forename: S
authors.initials: S
authors.lastname: Maruyama
authors.forename: T
authors.initials: T
authors.lastname: Ishido
authors.forename: Y
authors.initials: Y
authors.lastname: Tokunaga
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology*; D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D002540:Cerebral Cortex / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D009474:Neurons / Q000276:immunology; D011817:Rabbits; D012559:Schizophrenia / Q000276:immunology*
chemical_list: D001323:Autoantibodies