appR gene product activates transcription of microcin C7 plasmid genes.
Microcin C7 (MccC7) is encoded by Escherichia coli plasmid pMccC7. However, some strains of E. coli K-12 carrying this plasmid do not produce this antibiotic. Here we show that these strains differ in the gene locus appR. This chromosomal gene product controls MccC7 production by activating the transcription of some, but not all, MccC7 plasmid genes.
Díaz-Guerra
L
L
Unidad de Genética Molecular, Hospital Ramón y Cajal, Madrid, Spain.
Moreno
F
F
San Millán
J L
JL
D001430:Bacteriocins / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics*; D005786:Gene Expression Regulation; D005798:Genes, Bacterial; D010957:Plasmids; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic
D001430:Bacteriocins; D014157:Transcription Factors; C020411:microcin