[Disorders of cardiac contractile function in ischemic shock; the protective effect of antioxidants and liposomes made from egg phospholipids].
Experiments were made on Wistar rats with 6h tourniqueting of the hind limbs to study animal survival rate, myocardial contractile function and protective action of antioxidants and egg phospholipid liposomes during ischemic shock. It has been shown that reperfusion of the limbs leads to a high animal lethality, make lower myocardial contractile function and coronary flow of the hearts isolated from rats following a 6h reperfusion of the limbs. Well-known antioxidant butylated hydroxytoluene and a new antioxidant tetramethylpiperidine derivative bring animal lethality down and improve coronary flow and contractile function of the isolated heart. Phospholipid liposomes increase survival rate moderately but have no any effect on the heart contractile function. It has been deduced that lipid peroxidation takes part in the disturbance of heart contractile function and genesis of the death within ischemic shock.
Bilenko
M V
MV
Morgunov
A A
AA
Churakova
T D
TD
Bulgakov
V G
VG
Komarov
P G
PG
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology*; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008081:Liposomes; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology*; D010743:Phospholipids / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012770:Shock, Cardiogenic / Q000188:drug therapy / Q000209:etiology / Q000401:mortality / Q000503:physiopathology*; D013997:Time Factors
D000975:Antioxidants; D004337:Drug Carriers; D008081:Liposomes; D010743:Phospholipids
Narusheniia sokratitel'noĭ funktsii serdtsa pri ishemicheskom shoke; zashchitnyĭ éffekt antioksidantov i liposom iz iaichnykh fosfolipidov.