title: Extradural pressure following the injection of two volumes of bupivacaine.
abstract: We investigated the influence of the pressure generated by low lumbar extradural injection of bupivacaine on the development of block in a randomized double-blind study. Thirty patients (aged 17-66 yr) received one of two volumes of 0.75% bupivacaine. Group I (n = 15) received 10 ml (75 mg) and group II (n = 15) 15 ml (112.5 mg). Injection of the larger volume resulted in a greater pressure at the end of injection, but within 1 min this decayed to the same plateau pressure that was produced by the smaller volume. Mean maximum cephalad spread of block was the same in each group (group I, T9.5; group II, T8.4) and there was no correlation between individual level of block and maximum or plateau extradural pressure, or with patient characteristics.
authors.affiliation: Department of Anaesthetics, Royal Infirmary, Edinburgh.
authors.forename: D L
authors.initials: DL
authors.lastname: Paul
authors.forename: J A
authors.initials: JA
authors.lastname: Wildsmith
mesh_terms: D000328:Adult; D000698:Analgesia; D000767:Anesthesia, Epidural; D002045:Bupivacaine / Q000008:administration & dosage*; D015170:Cerebrospinal Fluid Pressure / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007268:Injections, Epidural; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D011897:Random Allocation
chemical_list: D002045:Bupivacaine