title: [Hodgkin disease, stage I through III A: treatment results at the Zurich University Hospital from 1974 to 1985 and current procedures].
abstract: 1974 to 1985, 148 patients with M. Hodgkin I to III A have been treated at the University Hospital Zurich with radiotherapy or radiotherapy and chemotherapy. Ten year survival rates (recurrence free) are: all patients 88% (67%); all with primary radiotherapy 88% (58%); PS I A/II A and radiotherapy 94% (63%); PS III A and primary radiotherapy 78% (56%); patients with recurrence after primary radiotherapy 69% (73%).
  
  
  RESULTS
  four cases of acute leukaemia, one case of pancytopenia and sepsis and one case with a myeloproliferative syndrome. Cumulative frequency of leukaemia after ten years is about 7%. Three patients suffered from secondary solid neoplasia. 94% of all living patients are free of symptoms and are working 100%. Based on Ann-Arbor stage, number and volume of involved regions, age, histology, general symptoms and the sedimentation rate, patients with M. Hodgkin CS I to III A can be subdivided in three groups with the following risks of recurrence after primary irradiation without staging laparotomy and splenectomy: a favourable group with a recurrence risk of about 20%. For these patients, primary radiotherapy after clinical staging is an acceptable therapy. In a second group with a high recurrence risk of greater than 50% after irradiation, primary chemotherapy is indicated, usually with additional irradiation of the main tumour manifestations. In a third group with a medium recurrence risk, laparotomy may be further indicated.
authors.forename: C
authors.initials: C
authors.lastname: Glanzmann
authors.forename: U
authors.initials: U
authors.lastname: Strebel
authors.forename: W
authors.initials: W
authors.lastname: Seelentag
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006689:Hodgkin Disease / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007813:Laparotomy; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D011379:Prognosis; D011867:Radioisotope Teletherapy; D011879:Radiotherapy Dosage; D012008:Recurrence
vernacular_title: Morbus Hodgkin, Stadien I bis III A: Behandlungsergebnisse am Universitätsspital Zürich von 1974 bis 1985 und aktuelles Prozedere.