title: Influence of albumin and non-esterified fatty acids on serum prostacyclin binding in pregnancy.
abstract: We investigated the etiology of the previously documented decrease in serum prostocyclin binding during pregnancy. Addition of albumin to the serum of pregnant women failed to raise binding to non-pregnant levels. Pregnancy serum bound significantly more prostacyclin following the removal of non-esterified fatty acids and the addition of fatty acid free albumin resulted in a rise in binding to non-pregnant levels. We conclude that serum protein prostacyclin binding is affected by both albumin concentration and non-esterified fatty acids.
authors.affiliation: Dept. of Obstetrics and Gynecology, Univ. of South Florida, College of Medicine, Tampa 33612.
authors.forename: W F
authors.initials: WF
authors.lastname: O'Brien
authors.forename: H I
authors.initials: HI
authors.lastname: Saba
authors.forename: R A
authors.initials: RA
authors.lastname: Knuppel
authors.forename: R
authors.initials: R
authors.lastname: Benoit
authors.forename: A
authors.initials: A
authors.lastname: Bruce
mesh_terms: D001798:Blood Proteins / Q000378:metabolism; D011464:Epoprostenol / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D001798:Blood Proteins; D005230:Fatty Acids, Nonesterified; D012709:Serum Albumin; D011464:Epoprostenol