Antibiotic prophylaxis in acute nonperforated appendicitis. The Danish Multicenter Study Group III.
In a prospective, block-randomized, multicenter study, the safety and efficacy of cefoxitin in preoperative prophylaxis were studied. 1735 patients undergoing appendectomy were evaluable, and half of these patients received 2 g of cefoxitin before undergoing operation. The patients were divided into three groups: patients with a normal appendix, patients with an acutely inflamed appendix, and patients with a gangrenous appendix. The study showed for each group a significant reduction of the incidence of wound infection in patients receiving prophylaxis. However, intra-abdominal abscess formation was not influenced by preoperative antibiotic prophylaxis. Consequently, routine preoperative prophylaxis is recommended before appendectomy.
Bauer
T
T
Department of Surgery, General Hospital of Roenne, Denmark.
Vennits
B
B
Holm
B
B
Hahn-Pedersen
J
J
Lysen
D
D
Galatius
H
H
Kristensen
E S
ES
Graversen
P
P
Wilhelmsen
F
F
Skjoldborg
H
H
D000005:Abdomen; D000038:Abscess / Q000517:prevention & control; D000208:Acute Disease; D000328:Adult; D001062:Appendectomy; D001064:Appendicitis / Q000601:surgery*; D002440:Cefoxitin / Q000627:therapeutic use*; D003718:Denmark; D005260:Female; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000517:prevention & control*
D002440:Cefoxitin