title: Central odontogenic fibroma, granular cell variant. A case report with S-100 immunohistochemistry and a review of the literature.
abstract: We have identified 14 cases that over the last 40 years have been reported under a series of names, most commonly granular cell ameloblastic fibroma. An additional case in the mandibular premolar region of a 45-year-old woman is described. The tumor was conservatively removed and 4 years later shows no evidence of recurrence. On the basis of our examination of the clinical and histologic features of this lesion and a comparison with the previous cases, we agree with the recent suggestion that the tumor should be designated as a central odontogenic fibroma, granular cell variant. By means of S-100 protein immunostaining techniques, the granular cells in this lesion were compared with the granular cell population in a granular cell tumor (myoblastoma) and the mesenchymal component of an ameloblastic fibroma. The results reveal a lack of S-100 protein reactivity in the granular cells of the central odontogenic fibroma and suggest an origin of those cells different from the origin of cells in a granular cell tumor.
authors.affiliation: School of Medicine, University of North Carolina at Chapel Hill.
authors.forename: B C
authors.initials: BC
authors.lastname: Shiro
authors.forename: J R
authors.initials: JR
authors.lastname: Jacoway
authors.forename: S A
authors.initials: SA
authors.lastname: Mirmiran
authors.forename: W F
authors.initials: WF
authors.lastname: McGuirt
authors.forename: G P
authors.initials: GP
authors.lastname: Siegal
mesh_terms: D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology; D005260:Female; D005350:Fibroma / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008339:Mandibular Neoplasms / Q000473:pathology*; D008875:Middle Aged; D009808:Odontogenic Tumors / Q000473:pathology*; D009418:S100 Proteins
chemical_list: D009418:S100 Proteins