title: Urinary mutagenicity tests in lead-exposed workers.
abstract: Urinary mutagenic activity detected by the bacterial fluctuation assay, using Salmonella typhimurium TA98 and Escherichia coli WP2 uvrA with and without metabolic activation (S9 mix), was studied in a group of 21 workers exposed to inorganic lead and a control group of 22 non-occupationally exposed subjects. Occupational exposure to inorganic lead had no effect on urinary mutagenicity in the strains considered, with or without metabolic activation. In smokers (exposed and non-exposed), urinary mutagenic activity appeared to increase compared to non-smokers (exposed and non-exposed), only with Salmonella typhimurium TA98 in the presence of S9 mix.
authors.affiliation: Cattedra di Medicina del Lavoro, University of Brescia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Apostoli
authors.forename: R
authors.initials: R
authors.lastname: Leone
authors.forename: S
authors.initials: S
authors.lastname: Porru
authors.forename: M E
authors.initials: ME
authors.lastname: Fracasso
authors.forename: L
authors.initials: L
authors.lastname: Alessio
mesh_terms: D000328:Adult; D003404:Creatinine / Q000652:urine; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D007855:Lead Poisoning / Q000235:genetics* / Q000652:urine; D008297:Male; D008875:Middle Aged; D009152:Mutagenicity Tests; D009784:Occupational Diseases / Q000235:genetics* / Q000652:urine; D012307:Risk Factors; D012486:Salmonella typhimurium / Q000235:genetics; D012907:Smoking / Q000235:genetics; D014556:Urine / Q000382:microbiology*
chemical_list: D003404:Creatinine