title: Comparative study of three different dosing regimens of cefotaxime for treatment of gram-negative bacteremia.
abstract: Thirty-one patients with Gram-negative bacteremia with organisms susceptible to cefotaxime (CTX) (MIC of 1 microgram/ml or less) were randomized to receive 2 g of CTX every 6, 8, or 12 hr. Five-hour susceptibility studies were performed on a bacterial pellet obtained from the patient's positive blood culture vial. Thus, patients were enrolled within hours after Gram-negative organisms were demonstrated in their blood cultures. All bacteremias were cleared although two patients had unsatisfactory responses to therapy. Trough serum bactericidal levels were 1:2 or greater in all patients. This study supports that CTX can be used at an 8- or 12-hr intervals in selected patients with Gram-negative bacteremia.
authors.affiliation: Department of Medicine, Presbyterian-St. Luke's Medical Center Chicago, Illinois 60612.
authors.forename: G M
authors.initials: GM
authors.lastname: Trenholme
authors.forename: B A
authors.initials: BA
authors.lastname: Schmitt
authors.forename: J A
authors.initials: JA
authors.lastname: Nelson
authors.forename: L C
authors.initials: LC
authors.lastname: Gvazdinskas
authors.forename: B B
authors.initials: BB
authors.lastname: Harrison
authors.forename: G W
authors.initials: GW
authors.lastname: Parkhurst
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002439:Cefotaxime / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D012477:Salmonella enteritidis / Q000187:drug effects; D018805:Sepsis / Q000188:drug therapy*; D012706:Serratia marcescens / Q000187:drug effects
chemical_list: D002439:Cefotaxime