title: The application of radionuclide ventriculography to cardiac screening.
abstract: Screening asymptomatic individuals for latent coronary disease often requires sequential testing because exercise electrocardiography typically produces more false positive than true positive results in a population with a low prevalence of coronary disease. Cardiac scintigraphy is a technique that may be employed as a confirmatory test in lieu of coronary arteriography to further evaluate the significance of a positive exercise electrocardiogram. Radionuclide ventriculography was employed in 98 asymptomatic individuals who were considered to be at moderate risk of heart disease after risk factor analysis and exercise electrocardiography. Seventeen (17%) patients had an abnormal study and underwent cardiac catheterization. Seven had coronary artery disease, two had cardiomyopathy, and eight were normal. Eighty-one (83%) patients had a normal study. Because the sensitivity of radionuclide ventriculography is 63-80%, it was postulated that 2 to 5 individuals with disease were missed. Thus, from a population with an 11-14% prevalence of disease, two subsets were identified. A large subset in which a prevalence of 2-6% could be estimated was separated from a much smaller one in which a prevalence of approximately 50% was demonstrated.
authors.affiliation: Department of Medicine, George Washington University School of Medicine, Washington, DC.
authors.forename: J
authors.initials: J
authors.lastname: Lindsay
authors.forename: M R
authors.initials: MR
authors.lastname: Milner
authors.forename: P L
authors.initials: PL
authors.lastname: Chandeysson
authors.forename: D J
authors.initials: DJ
authors.lastname: Rodman
authors.forename: P M
authors.initials: PM
authors.lastname: Okin
authors.forename: S A
authors.initials: SA
authors.lastname: Goldstein
mesh_terms: D000328:Adult; D000792:Angiography; D006328:Cardiac Catheterization; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012680:Sensitivity and Specificity