[The lymphoid system and protein deficiency. Differentiation in the thymus and Peyer's patches].
A: Thymuses from protein deprived rats present: 1) a significant decrease in the absolute number of thymic cells bearing the CD5 phenotype (OX19+), as well as Thy 1.1 (OX7+). The predominant cell population was the one containing TdT (terminal deoxynucleotidyl transferase) as a sole marker: 2) in severely protein deprived rats followed by refeeding during 9 and 21 days, the existence of a small population of cells containing TdT as a sole marker. The TdT+W3/13+ cell population was restored but the CD4+ subpopulation (W3/25+) exists in lower numbers than in the age-matched controls. B: Severe protein deficiency at weaning, led to the presence in the Peyer's patches of very immature B-cells mostly c mu+OX7s mu-. Protein refeeding reinitiated the differentiation process as follows: 1) c mu+OX7+s mu- c mu-OX7-s mu+ as in the normal Peyer's patches; 2) however, switching of sIgM to sIgA-bearing cells was altered; 3) a low absolute number of W3/13+ and W3/25+ T-cells (CD4+) was found. C: Oral tolerance to dextrin evolved due to antigen specific CD8+ T-cells (found in Peyer's patches, mesenteric lymph nodes and spleen) and could be transferred to normal recipients.
Roux
M E
ME
López
M C
MC
Melton
E
E
Slobodianik
N H
NH
González Ariki
S
S
García
P
P
D000818:Animals; D015704:CD4 Antigens / Q000032:analysis; D007111:Immunity, Cellular; D007070:Immunoglobulin A / Q000032:analysis; D010581:Peyer's Patches / Q000473:pathology*; D011488:Protein Deficiency / Q000150:complications*; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000473:pathology*
D015704:CD4 Antigens; D007070:Immunoglobulin A
Sistema linfoide y deficiencia proteica. Diferenciación en timo y placas de Peyer.