title: Bleeding prophylaxis in autologous bone marrow transplantation for solid tumors. Comparison of cryopreserved autologous and fresh allogeneic single-donor platelets.
abstract: Bleeding prophylaxis with cryopreserved autologous thrombocytes was evaluated in 43 patients treated with high-dose chemotherapy and autologous bone marrow transplantation. Platelet transfusions were given prophylactically. Nineteen patients received only autologous, 10 only fresh allogeneic single-donor, and 14 both types of transfusions. The effects of 104 autologous versus 93 allogeneic thrombocyte transfusions were compared. The increment at 1 h was for allogeneic platelets twice that for autologous platelets (30.6 versus 15.2 x 10(9)/l), but the interval between transfusions in days (2.3) was the same. Twelve patients received alternating autologous platelet transfusion after washing out the cryoprotectant dimethyl sulfoxide (18 transfusions) and non-washed autologous platelets (24 transfusions). Platelet increments, corrected increments, and predicted recovery were not influenced by omitting the washing procedure, and no side effects of dimethyl sulfoxide occurred.
authors.affiliation: Department of Internal Medicine, State University Hospital, Groningen, The Netherlands.
authors.forename: P O
authors.initials: PO
authors.lastname: Mulder
authors.forename: A
authors.initials: A
authors.lastname: Maas
authors.forename: E G
authors.initials: EG
authors.lastname: de Vries
authors.forename: J L
authors.initials: JL
authors.lastname: Orie
authors.forename: D T
authors.initials: DT
authors.lastname: Sleijfer
authors.forename: C T
authors.initials: CT
authors.lastname: Smit Sibinga
authors.forename: P H
authors.initials: PH
authors.lastname: Willemse
authors.forename: N H
authors.initials: NH
authors.lastname: Mulder
mesh_terms: D000328:Adult; D000368:Aged; D001793:Blood Preservation; D001804:Blood Transfusion, Autologous; D016026:Bone Marrow Transplantation; D004121:Dimethyl Sulfoxide; D005260:Female; D005615:Freezing; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D017713:Platelet Transfusion
chemical_list: D004121:Dimethyl Sulfoxide