title: Lack of importance of caffeine as an analgesic adjuvant of dipyrone in mice.
abstract: The analgesic effect of caffeine used alone and in combination with dipyrone and butalbital was evaluated after oral administration in mice, using two different pain tests: the hot plate test and the phenylbenzoquinone-induced writhing test. Neither caffeine (5 to 200 mg/kg) nor butalbital (10 and 20 mg/kg) (20 mg/kg was the highest dose that did not induce sleep) produced a significant antinociceptive effect, whereas dipyrone was active from 400 mg/kg in the hot plate test and from 50 mg/kg in the writhing test. The scores obtained with the combinations were not different from those of the dipyrone-treated group, except for the butalbital-dipyrone combination. Thus caffeine is not an analgesic adjuvant in mice; its presence in the combination studied appears to be justifiable only insofar as it inhibited the sedative effect of butalbital.
authors.affiliation: Laboratoire de Pharmacologie et Pharmacie Clinique, Faculté de Pharmacie, INSERM U195, Faculté de Médecine, Clermont-Ferrand, France.
authors.forename: J
authors.initials: J
authors.lastname: Fialip
authors.forename: A
authors.initials: A
authors.lastname: Porteix
authors.forename: H
authors.initials: H
authors.lastname: Marty
authors.forename: A
authors.initials: A
authors.lastname: Eschalier
authors.forename: P
authors.initials: P
authors.lastname: Duchêne-Marullaz
mesh_terms: D000632:Aminopyrine / Q000031:analogs & derivatives*; D000700:Analgesics; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D016227:Benzoquinones; D002110:Caffeine / Q000494:pharmacology*; D004177:Dipyrone / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011809:Quinones / Q000037:antagonists & inhibitors; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000700:Analgesics; D001463:Barbiturates; D016227:Benzoquinones; D011809:Quinones; D000632:Aminopyrine; C029322:phenylbenzoquinone; D002110:Caffeine; D004177:Dipyrone; C004470:butalbital