title: Plasmodium berghei: malaria infection causes increased cardiac output in rats, Rattus rattus.
abstract: Thirty-two 4-week-old male Wistar rats were infected with Plasmodium berghei malaria. On Days 12 through 14, blood volume, arterial blood pressure, right ventricular pressure, heart rate, cardiac output, stroke volume, hematocrit, and vascular resistances were determined. All of the cardiovascular parameters measured, with the exception of calculated pulmonary vascular resistance, changed progressively as the peripheral blood parasitemia increased. With a rising parasitemia, cardiac output increased, despite a reduced heart rate. The highest parasitemia of 63% was accompanied by a doubling of the normal cardiac output. The relationship between parasitemia and cardiac output can be described by the equation, cardiac output = (6.14) x % parasitemia + 452 ml/min/kg. The mean arterial blood pressure was lower than controls when parasitemia exceeded 20%, whereas systolic right ventricular pressure was elevated only at the highest parasitemias. When noninfected control rats were compared with those animals having parasitemias greater than 40%, in the infected animals, mean arterial pressure was 28% lower (P less than 0.01) and systolic right ventricular pressure rose by 21% (P less than 0.02). A 50% decline was observed in the total peripheral vascular resistance (P less than 0.01), although the pulmonary resistance was apparently unchanged. With P. berghei infection, there is also a marked anemia, an increase in plasma volume, and a 16% increase in blood volume (% body weight). It is concluded from these results that although the hemodynamic changes previously reported in the literature indicate that infection with malaria may result in focal blockages in microvessels and poor tissue perfusion, the total systemic effect, in the rat, is an increase in cardiac output secondary to a reduced peripheral resistance.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
authors.forename: K K
authors.initials: KK
authors.lastname: Shida
authors.forename: B
authors.initials: B
authors.lastname: Lewchalermvongse
authors.forename: L W
authors.initials: LW
authors.lastname: Pang
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D001835:Body Weight; D002302:Cardiac Output; D002319:Cardiovascular System / Q000503:physiopathology*; D006339:Heart Rate; D006400:Hematocrit; D008288:Malaria / Q000503:physiopathology*; D008297:Male; D010953:Plasma Volume; D010962:Plasmodium berghei; D051381:Rats; D011919:Rats, Inbred Strains; D013318:Stroke Volume; D014655:Vascular Resistance