Vaccination of mice against Mycobacterium leprae infection.
Intradermal immunization with killed Mycobacterium leprae renders mice immune to infection with viable M. leprae. This protection is long lasting and systemic in that immunization in the left flank results in protection in both the left and right footpads. Immunization with Mycobacterium vaccae was ineffective in protecting mice against M. leprae infection, while Mycobacterium bovis BCG provided partial protection. Mycobacterium habana TMC 5135 (now known as Mycobacterium simiae) was found to be as effective as M. leprae in protecting mice against footpad infection.
Singh
N B
NB
Laboratory for Leprosy and Mycobacterial Research, National Institute for Medical Research, London, United Kingdom.
Lowe
A C
AC
Rees
R J
RJ
Colston
M J
MJ
D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D007918:Leprosy / Q000276:immunology* / Q000517:prevention & control; D051379:Mice; D009166:Mycobacterium leprae / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control
D001500:BCG Vaccine; D001428:Bacterial Vaccines