Effect of some quinolizidine derivatives on the release of serotonin, noradrenaline, dopamine and acetylcholine from rat brain synaptosomes.
A set of eleven quinolizidine derivatives together with 10-(quinuclidinyl)phenothiazine, promazine and methixene were tested for their effects on the spontaneous release of serotonin, noradrenaline, dopamine and acetylcholine from rat brain synaptosomes. All tested compounds failed to increase the acetylcholine release, while several of them exhibited rather strong effects on serotonin, noradrenaline and dopamine release at 5-10 microM concentrations. Structure-activity relationships are discussed.
Sparatore
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Istituto di Chimica Biologica, Università di Genova, Italy.
Marchi
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Maura
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Raiteri
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D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D011807:Quinolizines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D011807:Quinolizines; D012701:Serotonin; D000109:Acetylcholine; D004298:Dopamine; D009638:Norepinephrine