title: Vancomycin and ceftazidime in the treatment of CAPD peritonitis.
abstract: 102 episodes of continuous ambulatory peritoneal dialysis (CAPD) peritonitis were studied prospectively during a 288-day period at The Queen Elizabeth Hospital, Birmingham. Organisms were isolated from 76% of the episodes, with coagulase-negative staphylococci, being the most commonly encountered organism (55%). Initial treatment consisted of intraperitoneal vancomycin and ceftazidime with subsequent adjustment on the basis of antibiotic sensitivities. With this regimen, 83% of the positive cultures became negative by 72 h, 9.8% of cases relapsed and removal of the CAPD catheter was necessary in 8 patients (7.8%). Overall, 92% of cases were cured. No adverse drug reactions were seen. This combination of antibiotics appears effective and safe in the treatment of CAPD peritonitis.
authors.affiliation: Department of Nephrology, Queen Elizabeth Hospital, Birmingham, UK.
authors.forename: M
authors.initials: M
authors.lastname: Beaman
authors.forename: L
authors.initials: L
authors.lastname: Solaro
authors.forename: R J
authors.initials: RJ
authors.lastname: McGonigle
authors.forename: J
authors.initials: J
authors.lastname: Michael
authors.forename: D
authors.initials: D
authors.lastname: Adu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002442:Ceftazidime / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology; D014640:Vancomycin / Q000008:administration & dosage*
chemical_list: D014640:Vancomycin; D002442:Ceftazidime