Hyperacute rejection of the transplanted mouse heart.
Mouse hearts transplanted heterotopically to MHC-disparate recipients can be hyperacutely rejected (HAR) after a single or 3 sequential donor type skin grafts, or a single intradermal injection of lymphoid cells. In the combinations tested, not all hearts are HAR; most of them are rejected in accelerated fashion. Our results with transplanted rat hearts are similar, even in a genetic combination for which HAR of all hearts has been reported. However, in rats, HAR tends to occur more rapidly and to be associated with more-intense vascular changes. Transfer of serum from mice or rats sensitized by 3 sequential skin grafts likewise resulted in occasional hyperacute but never accelerated rejection. Transfer of lymph node cells from mice sensitized with a single skin graft always resulted in accelerated but never in hyperacute rejection; transfer of cells after 3 sequential skin grafts caused neither accelerated nor hyperacute rejection.
Hisatake
G
G
Department of Pathology, University of Utah Medical Center, Salt Lake City 84132.
Hammond
E
E
Ives
M
M
Griffith
J
J
Shelby
J
J
Eichwald
E J
EJ
D000208:Acute Disease; D000818:Animals; D001803:Blood Transfusion; D005455:Fluorescent Antibody Technique; D006084:Graft Rejection; D016027:Heart Transplantation; D007114:Immunization; D007116:Immunization, Passive; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009206:Myocardium / Q000473:pathology / Q000648:ultrastructure; D011183:Postoperative Complications / Q000209:etiology / Q000473:pathology; D051381:Rats; D011912:Rats, Inbred ACI; D016038:Skin Transplantation