An overview of the retinoids.
The retinoids, a group of compounds consisting of vitamin A and its derivatives, have been the subject of intense investigation over the past 30 years. These molecules have shown beneficial effects in the areas of acne, psoriasis, neoplastic processes and, most recently, reversal of extrinsically aged skin. Additional retinoids are currently under development. Adverse reactions to these drugs include mucocutaneous irritation, hyperlipidemia, and profound teratogenicity. Appropriate patient selection is imperative before beginning therapy with these medications. An overview of retinoid metabolism and the currently available compounds is presented. The newest class of retinoids, the arotinoids, is also discussed.
Boyd
A S
AS
Department of Dermatology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock 79430.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D005050:Etretinate / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use; D011247:Pregnancy; D012176:Retinoids / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy; D014212:Tretinoin / Q000627:therapeutic use
D012176:Retinoids; D014212:Tretinoin; D005050:Etretinate; D015474:Isotretinoin