Meningeal tumors of childhood.
Meningeal tumors occurring in a pediatric hospital over a period of 18 years were studied. The incidence of meningeal sarcomas was much lower than has been previously reported. A histologic subtype of meningiomas was found which has not previously been described. In these "sclerosing" tumors only a small portion of the lesion contained viable cells, most of which bore little resemblance to conventional meningothelial cells. The bulk of the lesions consisted of whorling collagen bundles produced by the tumor. All cases in which there was tumor invasion of the brain fell into this category. The prognosis for the sclerosing meningiomas was similar to conventional meningiomas, casting doubt on the value of brain invasion as a marker of malignancy in childhood meningiomas. The recognition of this histologic type may aid diagnosis, guide surgical management, and possibly make postoperative radiotherapy unnecessary.
Davidson
G S
GS
Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada.
Hope
J K
JK
D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000032:analysis; D005260:Female; D006393:Hemangiopericytoma / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008297:Male; D008545:Melanoma / Q000473:pathology; D008577:Meningeal Neoplasms / Q000473:pathology*; D008579:Meningioma / Q000473:pathology*; D012509:Sarcoma / Q000473:pathology
D003094:Collagen