Cytogenetic abnormalities in a secondary lymphoma complicating cardiac transplantation.
We report a case of secondary lymphoma in the brain in a cardiac transplant recipient. Cytogenetic analysis revealed the presence of clonal cytogenetic abnormalities. Two clones with unrelated chromosomal abnormalities were noted; in both abnormal clones, trisomy for the long arm of chromosome 11 was observed. Our observations, combined with single cases previously reported, suggest that a gain of the long arm of chromosome 11 may represent a characteristic cytogenetic abnormality that is associated with secondary lymphoma.
Olopade
O L
OL
Department of Medicine, University of Chicago Hospital and Clinic, Illinois.
Anastasi
J
J
Thangavelu
M
M
Le Beau
M M
MM
Golomb
H M
HM
D000328:Adult; D001932:Brain Neoplasms / Q000209:etiology / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D008223:Lymphoma / Q000209:etiology / Q000235:genetics*; D014314:Trisomy