A search for bcl1, bcl2, and c-myc oncogene rearrangements in chronic lymphocytic leukemia.
Three cellular or putative oncogenes: c-myc, bcl1, and bcl2 were previously found to be rearranged in some B cell malignancies due to chromosomal translocations. Data concerning the role of such genetic rearrangements in B-CLL are very scanty and limited to few cases in which bcl1 rearrangements were found. We studied DNA samples from 38 cases of B-CLL by Southern blot technique in order to find out the existence and frequency of such events. No bcl1 or bcl2 rearrangements were found in any of the studied cases; thus, involvement of these genes in CLL must be rare. In one patient who had an aggressive and resistant disease, c-myc rearrangement was found.
Rechavi
G
G
Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Katzir
N
N
Brok-Simoni
F
F
Holtzman
F
F
Mandel
M
M
Gurfinkel
N
N
Givol
D
D
Ben-Bassat
I
I
Ramot
B
B
D000328:Adult; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male; D015335:Molecular Probes; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D014178:Translocation, Genetic
D015335:Molecular Probes; D011518:Proto-Oncogene Proteins