title: In vitro effects of levamisole and ivermectin against Echinococcus granulosus protoscoleces.
abstract: The in vitro effects of levamisole and ivermectin against Echinococcus granulosus protoscoleces were studied by means of light and electron microscopy. Both drugs had a protoscolicidal activity that increased proportionally with increasing concentrations of the drugs. Ivermectin showed the more rapid effects and caused contraction and paralysis of protoscoleces. A paralyzing effect was also observed with levamisole, followed by irreversible tissue vacuolation leading to death.
authors.forename: N
authors.initials: N
authors.lastname: Casado
authors.forename: F
authors.initials: F
authors.lastname: Rodriguez-Caabeiro
authors.forename: A
authors.initials: A
authors.lastname: Jiménez
authors.forename: A
authors.initials: A
authors.lastname: Criado
authors.forename: C
authors.initials: C
authors.lastname: de Armas
mesh_terms: D000818:Animals; D004446:Echinococcus / Q000187:drug effects* / Q000648:ultrastructure; D007559:Ivermectin / Q000494:pharmacology*; D007978:Levamisole / Q000494:pharmacology*; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning
chemical_list: D007978:Levamisole; D007559:Ivermectin