Alprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks.
Fifty-five patients completed a 5-week double-blind study comparing alprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks. There was no concomitant behavioral treatment. Patient and therapist rating scales included Sheehan's Panic and Anxiety Attack Scales, the Marks-Sheehan Phobia Scale, the Hamilton Anxiety Scale, the Hamilton Depression Scale, and the Side Effects Checklist. The results generally support the efficacy of alprazolam, but not propranolol, in the treatment of panic disorder and agoraphobia with panic attacks. The significance of the results are discussed, as well as a number of the unique aspects of our procedures and patient population.
Munjack
D J
DJ
University of Southern California Medical School.
Crocker
B
B
Cabe
D
D
Brown
R
R
Usigli
R
R
Zulueta
A
A
McManus
M
M
McDowell
D
D
Palmer
R
R
Leonard
M
M
D000293:Adolescent; D000328:Adult; D000379:Agoraphobia / Q000188:drug therapy* / Q000523:psychology; D000525:Alprazolam / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005239:Fear / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000187:drug effects*; D010698:Phobic Disorders / Q000188:drug therapy*; D011433:Propranolol / Q000627:therapeutic use*; D011581:Psychological Tests
D011433:Propranolol; D000525:Alprazolam