Pharmacokinetics of cefotaxime and desacetylcefotaxime in the newborn.
A study of the pharmacokinetic parameters of cefotaxime (CTX) and desacetylcefotaxime (dCTX) in newborns was conducted; the former is commonly used for neonatal infections. The elimination half life of CTX correlated with gestational age (GA) and postnatal age (PNA). Elimination of dCTX was longer permitting a synergistic or additive effect with CTX against Gram-negative bacteria. CTX is indicated in the treatment of neonatal sepsis because of the increasing resistance of Escherichia coli to ampicillin and its good efficacy against group B streptococcus.
Aujard
Y
Y
Neonatal Unit, Hopital Robert Debre, Paris, France.
Brion
F
F
Jacqz-Aigrain
E
E
Kasse
M C
MC
Chretien
P
P
Criqui
C
C
Mathieu
H
H
D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000494:pharmacology; D004334:Drug Administration Schedule; D004926:Escherichia coli / Q000187:drug effects; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D013292:Streptococcus agalactiae / Q000187:drug effects
C029281:desacetylcefotaxime; D002439:Cefotaxime