Intravascular coagulation in the development of massive hepatic necrosis induced by Corynebacterium parvum and endotoxin in rats.
When Escherichia coli endotoxin was intravenously injected into rats given killed Corynebacterium parvum 6 days previously, fibrin deposition and endothelial cell injury occurred in hepatic sinusoids at 1.5 h and were intensified thereafter. Serum alanine aminotransferase values were increased along with prothrombin time and decreased plasma levels of antithrombin III and coagulation factor VIII:C at 5 h. Antithrombin III concentrate (plus heparin) or superoxide dismutase infused concurrently with injection of endotoxin significantly attenuated the derangements of these variables and the histologic extent of liver injury at 5 h. Intravascular coagulation, probably developing through the action of superoxide anion, may contribute to the development of massive hepatic necrosis induced by C. parvum and endotoxin in rats.
Yamada
S
S
First Dept. of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Ogata
I
I
Hirata
K
K
Mochida
S
S
Tomiya
T
T
Fujiwara
K
K
D000805:Angiotensin III / Q000008:administration & dosage; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D004730:Endothelium, Vascular / Q000473:pathology* / Q000648:ultrastructure; D004731:Endotoxins / Q000008:administration & dosage*; D004926:Escherichia coli; D006493:Heparin / Q000008:administration & dosage; D008099:Liver / Q000098:blood supply / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D009336:Necrosis; D011425:Propionibacterium acnes; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000008:administration & dosage; D013997:Time Factors
D004731:Endotoxins; D000805:Angiotensin III; D006493:Heparin; D013482:Superoxide Dismutase