title: The significance of the ipazyme IgA and IgG antibody test in the diagnosis of urogenital chlamydial infections.
abstract: Urogenital specimens from 200 male and female patients were cultivated for the detection of C. trachomatis. For comparison, serum of the same patients was investigated with the Ipazyme IgA and IgG test. This comparison of culture and serological tests revealed a sensitivity of the IgA Ipazyme test of 56% and a specificity of 81%. For the IgG Ipazyme test, the corresponding values were 77% and 39%. The sensitivity of the conventional immunofluorescence test reached 46% and its specificity was 50% for the same group of patients. Antibiotic treatment of 13 IgA-positive patients resulted in a significant decrease of the titre in only one case. The introduction of the Ipazyme test does not open a new aspect in chlamydial serology, i.e. the diagnostic value of serology for the detection of a current chlamydial infection remains low.
authors.affiliation: Universitäts-Hautklinik, Ruprecht-Karls-Universität, Heidelberg.
authors.forename: H
authors.initials: H
authors.lastname: Näher
authors.forename: D
authors.initials: D
authors.lastname: Petzoldt
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis; D002675:Child, Preschool; D002690:Chlamydia Infections / Q000175:diagnosis*; D002692:Chlamydia trachomatis / Q000276:immunology* / Q000302:isolation & purification; D005260:Female; D005455:Fluorescent Antibody Technique; D005831:Genital Diseases, Female / Q000175:diagnosis; D005832:Genital Diseases, Male / Q000175:diagnosis; D006801:Humans; D007124:Immunoenzyme Techniques; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007223:Infant; D008297:Male; D011237:Predictive Value of Tests; D014570:Urologic Diseases / Q000175:diagnosis
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G