Ischemia-reperfusion and cell membrane dysfunction.
One to 3 hours of partial skeletal muscle ischemia-reperfusion in dogs and rats causes cell membrane depolarization. Intracellular levels of adenosine triphosphate remain normal, suggesting that direct membrane injury rather than electrogenic pump failure occurs. Membrane depolarization can be prevented by superoxide dismutase and catalase, or by neutrophil depletion. Oxygen free radicals may be one type of mediator causing membrane damage, and it appears that leukocytes release these toxic species.
Perry
M O
MO
Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee.
Fantini
G
G
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002374:Catalase / Q000494:pharmacology; D002462:Cell Membrane / Q000502:physiology* / Q000648:ultrastructure; D004285:Dogs; D005260:Female; D005609:Free Radicals; D007511:Ischemia / Q000503:physiopathology; D008564:Membrane Potentials / Q000187:drug effects; D009132:Muscles / Q000098:blood supply / Q000473:pathology*; D009504:Neutrophils / Q000473:pathology; D010100:Oxygen / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000503:physiopathology*; D013482:Superoxide Dismutase / Q000494:pharmacology
D005609:Free Radicals; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D002374:Catalase; D013482:Superoxide Dismutase; D010100:Oxygen