[Fractional clearance of beta-2-microglobulin in the diagnostic and prognostic assessment of kidney diseases].
The micromolecular proteinuria (67-11 Kd), originating from tubulo-interstitial disorders, might be determined by SDS- or gradient-PAGE or by individual marker proteins. The latter procedure in addition to PAGE is necessary in case of heavy proteinurias. The tubular resorptive capacity for microproteins, analysed by fractional beta-2-M-clearances, decreases with deteriorating GFR. Values for FrCl beta 2M above the expected level were associated with tubulo-interstitial, but also with diabetic and rapidly progressing glomerular nephropathies. In the latter group these findings might be of prognostic importance. In contrast, the U-beta-2-M-determination in long term observation of kidney transplants had no diagnostic nor prognostic value.
Boesken
W H
WH
II. Medizinische Abteilung, Krankenhaus der Barmherzigen Brüder, Trier.
Effenberger
C
C
Krieger
H P
HP
Jammers
W
W
Stierle
H E
HE
D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis* / Q000652:urine; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D011183:Postoperative Complications / Q000175:diagnosis; D011379:Prognosis; D011507:Proteinuria / Q000175:diagnosis* / Q000652:urine; D012189:Retrospective Studies; D001613:beta 2-Microglobulin / Q000652:urine*
D001613:beta 2-Microglobulin
Fraktionelle Clearance des beta-2-Mikroglobulins in der Diagnose und Prognosestellung bei Nierenkrankheiten.