title: Dynamics of intercellular communication and differentiation in a rapidly developing mammalian airway epithelium.
abstract: A considerable body of data suggests that gap junctions represent channels that facilitate intercellular communication, thereby modulating growth and development. However, direct quantitative evidence supporting such a structure/function relationship is limited. This study has identified a new model in the rapidly developing tracheal epithelium of infant ferrets wherein gap junction prevalence and intercellular transfer of a fluorescent, low molecular weight dye, epithelial cell incorporation of tritiated thymidine, and progressive ciliation of the epithelium have been characterized. This developmental pattern provides favorable conditions for the study of relationships between gap junctions, intercellular translocation of chemical signals, and cell growth and differentiation in a mammalian airway epithelium with a minimum of experimental intervention.
authors.affiliation: Department of Pediatrics, University of North Carolina, Chapel Hill 27599-7220.
authors.forename: J L
authors.initials: JL
authors.lastname: Carson
authors.forename: N J
authors.initials: NJ
authors.lastname: Willumsen
authors.forename: T M
authors.initials: TM
authors.lastname: Gambling
authors.forename: S C
authors.initials: SC
authors.lastname: Hu
authors.forename: A M
authors.initials: AM
authors.lastname: Collier
mesh_terms: D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D004848:Epithelium / Q000502:physiology / Q000648:ultrastructure; D005260:Female; D005289:Ferrets; D005614:Freeze Fracturing; D007365:Intercellular Junctions / Q000502:physiology* / Q000648:ultrastructure; D008856:Microscopy, Fluorescence; D011247:Pregnancy; D014132:Trachea / Q000254:growth & development / Q000502:physiology*