The fate of meshed allograft skin in burned patients using cyclosporin immunosuppression.
Three patients with burns of 35%, 60% and 25% were treated with cyclosporin after the application of allograft skin. Biopsies of the allografts were taken at appropriate intervals. The drug was continued for 3 weeks, 3 months and 3 weeks respectively without ill-effects on the patients. The allografts survived during cyclosporin treatment but were rejected 12 days after cessation of treatment in Case 1 and 5-7 days in Case 2. In Case 3 where a meshed auto/allograft 'sandwich' technique was used, there was no visible evidence of rejection. It is likely that the allograft was replaced by a "creeping substitution" in the sandwich technique. The Langerhans cell is probably not solely responsible for allograft rejection.
Frame
J D
JD
Department of Plastic Surgery, Mount Vernon Hospital, Northwood, Middlesex.
Sanders
R
R
Goodacre
T E
TE
Morgan
B D
BD
D000328:Adult; D000368:Aged; D002056:Burns / Q000473:pathology / Q000601:surgery*; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D012867:Skin / Q000473:pathology; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D003524:Cyclosporins