title: Economic correction; quantity and age-related rate of change.
abstract: Correlation between the relative magnitude of activity or concentration in youth and the relative magnitude of age-related decrease occurs in several systems. We have observed this correlation in density of D2-dopamine receptors of the striatal membrane, activity of lymphocyte activated killer cells, relative density of CD8 on thymocytes, augmenting activity of T splenocytes and mRNA, coding for IL-1 in Langerhans cells. We have suggested that this correlation should be considered in the context of balanced investment in lifespan and reproductive efficiency, that it may be the result of feedback regulation and have designated it as "economic correction".
authors.affiliation: Department of Immunology and Clinical Immunology, University of Toronto, Hamilton, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Cinader
authors.forename: S
authors.initials: S
authors.lastname: Dubiski
authors.forename: C
authors.initials: C
authors.lastname: Greenwood
authors.forename: U
authors.initials: U
authors.lastname: Ponnappan
authors.forename: D N
authors.initials: DN
authors.lastname: Sauder
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology*; D000818:Animals; D005786:Gene Expression Regulation; D007694:Killer Cells, Natural / Q000502:physiology; D008017:Life Expectancy; D008222:Lymphokines / Q000502:physiology; D051379:Mice; D011954:Receptors, Dopamine / Q000032:analysis; D013950:Thymus Gland / Q000502:physiology
chemical_list: D008222:Lymphokines; D011954:Receptors, Dopamine