[Influence of subtotal gastrectomy on bile acid concentration, total bacterial counts in the gastric juice, and histologic changes in the gastric mucosa].
The concentrations of bile acids, PH and total bacterial counts in the gastric juice were measured among 44 patients with peptic ulcer before and after subtotal gastrectomy (Billroth II in 14 cases, Billroth I in 10 cases, and PAFPG in 20 cases). Thirty three patients were studied by endoscopy and gastric mucosa biopsy one year after the surgery. The results showed that the fasting gastric bile acids concentrations in both B-II and B-I groups were significantly higher than in PAFPG group, when examined 3 weeks and 1 year postoperatively. The PH and total bacterial counts in gastric juice were increased significantly after B-II and B-I reconstruction compared with PAFPG. The abnormal histology of gastric remnant mucosa was more common in B-II or B-I groups than in PAFPG (P less than 0.05). Our data demonstrated that B-II and B-I gastrectomy caused considerably enterogastric reflux, while PAFPG prevented it effectively by keeping the gastric physiology in a relatively stable status. It is the authors' belief that the results provide objective basis for selecting surgical procedure and evaluating operative effects.
Zhang
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D000328:Adult; D001647:Bile Acids and Salts / Q000032:analysis*; D001655:Bile Reflux / Q000209:etiology; D004381:Duodenal Ulcer / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects / Q000379:methods*; D005750:Gastric Juice / Q000032:analysis / Q000382:microbiology*; D005753:Gastric Mucosa / Q000473:pathology*; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006801:Humans; D008297:Male; D013276:Stomach Ulcer / Q000382:microbiology / Q000473:pathology / Q000601:surgery
D001647:Bile Acids and Salts