title: Conventional immunosuppression after deliberate third party transfusions versus cyclosporine in living related renal transplant recipients.
abstract: A total of 93 recipients of either HLA-identical (34) or 1-haplotype matched (59) living related donor renal transplants was assigned prospectively into immunosuppressive treatment groups on the basis of transfusion histories obtained at the initial evaluation for transplantation. Patients who received 0 to 2 third party transfusions were given no further transfusion, and received cyclosporine and prednisone immunosuppression after transplantation (cyclosporine group). Patients who received 3 or 4 third party transfusions were given additional transfusions until 5 had been received, and were managed with azathioprine and prednisone after transplantation (azathioprine group). Patients who already received 5 or more third party transfusions had no additional transfusions and were assigned to the azathioprine group. No patient had a positive crossmatch to the potential donor after initial evaluation and confirmation of a negative crossmatch. The number of rejection episodes per patient after transplantation was significantly higher in the azathioprine group for HLA-identical (p equals 0.001) and 1-haplotype (p equals 0.003) recipients. One-year patient survival rats for the HLA-identical cyclosporine and azathioprine groups were 100 and 94 per cent, respectively, with respective 1-year allograft survivals of 100 and 89 per cent in the 2 groups. In the 1-haplotype group 1-year patient survival rates were 95 and 94 per cent for the cyclosporine and azathioprine groups, respectively; allograft survival was 81 per cent for the cyclosporine group and 91 per cent for the azathioprine group. None of the observed differences in graft or patient survival between the 2 groups was statistically significant. Deliberate third party transfusions with conventional immunosuppression and cyclosporine immunosuppression are effective methods to treat recipients of living related donor renal transplants.
authors.affiliation: Department of Urology, Humana Hospital, San Antonio, Texas.
authors.forename: E E
authors.initials: EE
authors.lastname: Hodge
authors.forename: L H
authors.initials: LH
authors.lastname: Banowsky
authors.forename: A C
authors.initials: AC
authors.lastname: Novick
authors.forename: R M
authors.initials: RM
authors.lastname: Lewis
authors.forename: S B
authors.initials: SB
authors.lastname: Streem
authors.forename: D R
authors.initials: DR
authors.lastname: Steinmuller
authors.forename: J J
authors.initials: JJ
authors.lastname: Holzmann
authors.forename: L
authors.initials: L
authors.lastname: McFarlin
authors.forename: D E
authors.initials: DE
authors.lastname: Graneto
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D001803:Blood Transfusion; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D003524:Cyclosporins; D001379:Azathioprine; D011241:Prednisone