title: Case-control study of endemic diarrheal disease in Thai children.
abstract: In a year-long, case-control study of endemic diarrheal disease among 1230 Thai children less than five years of age, rotavirus was detected in 20%, Campylobacter in 13%, Shigella in 13%, Salmonella in 12%, and enterotoxigenic Escherichia coli (ETEC) in 9%. The differences in detection of enteric pathogens between patients and controls was significant for rotavirus (P less than .001), Shigella (P less than .001), ETEC that produced heat-labile and heat-stable toxins (LT and ST; P = .005), and ST only (P less than .001). C. jejuni was most significantly associated with diarrhea in children less than 12 months [corrected] old (P = .037) and Salmonella in children less than three months of age (P = .003). Enteropathogenic E. coli (EPEC) that adhered in a localized pattern to HeLa cells was isolated from 7% of patients and 3% of controls less than six months of age. Only 50% of these E. coli strains were of EPEC serotypes. Enteroinvasive E. coli was isolated from 7% of patients more than two years of age, and new serotypes were identified.
authors.affiliation: Armed Forces Research Institute of Medical Sciences, Children's Hospital, San Francisco, California 96346-5000.
authors.forename: P
authors.initials: P
authors.lastname: Echeverria
authors.forename: D N
authors.initials: DN
authors.lastname: Taylor
authors.forename: U
authors.initials: U
authors.lastname: Lexsomboon
authors.forename: M
authors.initials: M
authors.lastname: Bhaibulaya
authors.forename: N R
authors.initials: NR
authors.lastname: Blacklow
authors.forename: K
authors.initials: K
authors.lastname: Tamura
authors.forename: R
authors.initials: R
authors.lastname: Sakazaki
mesh_terms: D000367:Age Factors; D001422:Bacterial Adhesion; D002169:Campylobacter Infections / Q000382:microbiology / Q000503:physiopathology; D002675:Child, Preschool; D003967:Diarrhea / Q000382:microbiology* / Q000503:physiopathology; D004405:Dysentery, Bacillary / Q000382:microbiology / Q000503:physiopathology; D004926:Escherichia coli / Q000472:pathogenicity; D005873:Giardiasis / Q000469:parasitology / Q000503:physiopathology; D006801:Humans; D007223:Infant; D012400:Rotavirus Infections / Q000382:microbiology / Q000503:physiopathology; D012480:Salmonella Infections / Q000382:microbiology / Q000503:physiopathology; D013785:Thailand