Pulmonary embolism and cancer: predisposition to venous thrombosis and embolism as a paraneoplastic syndrome.
In patients with a malignant primary disease the risk of thromboembolic complication is demonstrably increased. This is undoubtedly attributable to a whole range of factors (multifactorial etiology) which are highlighted in the present synoptic study. In addition to local influences from the tumor, a particular role appears to be played by an increased aggregation of thrombocytes, various tumor cell products, polyglobulism, hypercalcemia, increased release of thrombocinase, microthrombotic embolization, and a decrease in antithrombin III.
Sons
H U
HU
Department of Surgery, Ferdinand-Sauerbruch-Klinikum Wuppertal, Federal Republic of Germany.
D006801:Humans; D009369:Neoplasms / Q000150:complications*; D010257:Paraneoplastic Syndromes; D010974:Platelet Aggregation; D011655:Pulmonary Embolism / Q000209:etiology*; D012307:Risk Factors; D013924:Thrombophlebitis / Q000209:etiology*