O-glycosylation pathway for mucin-type glycoproteins.
O-glycosylation is the post-translational process whereby carbohydrate is added to hydroxylated amino acids of proteins. The major O-glycosylation pathway in animal cells is involved in the synthesis of oligosaccharides linked by N-acetylgalactosamine to serine or threonine residues in 'mucin-type' proteins or their analogs. In this review, we discuss the evidence for the cellular localization of the biosynthetic steps in this pathway and propose a simplified, consensus version. We also propose variations of the simple pathway to account for its heterogeneity and variability in different cell types and differentiation states.
Carraway
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KL
Hull
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D000818:Animals; D002454:Cell Differentiation; D006031:Glycosylation; D006801:Humans; D009077:Mucins / Q000235:genetics*; D009369:Neoplasms / Q000378:metabolism; D009844:Oligosaccharides / Q000378:metabolism; D011499:Protein Processing, Post-Translational
D009077:Mucins; D009844:Oligosaccharides