Tamm-Horsfall protein accumulation in glomeruli during acetazolamide-induced acute renal failure.
A patient with ocular hypertension was treated with acetazolamide. Acute renal failure developed rapidly and renal biopsy showed mild tubular lesions and crystal formation in a tubular lumen. By immunofluorescence studies with a monoclonal antibody, Tamm-Horsfall protein, normally absent from the proximal segments of the nephron, was detected in most glomeruli. This strongly suggests that tubular obstruction plays a major part in some cases of acetazolamide-induced acute renal failure.
Rossert
J
J
Service de Néphrologie, Hôpital Tenon, Paris, France.
Rondeau
E
E
Jondeau
G
G
Ronco
P
P
Mougenot
B
B
Kanfer
A
A
Sraer
J D
JD
D000086:Acetazolamide / Q000009:adverse effects* / Q000627:therapeutic use; D058186:Acute Kidney Injury / Q000139:chemically induced*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009088:Mucoproteins / Q000378:metabolism*; D009798:Ocular Hypertension / Q000188:drug therapy; D058949:Uromodulin
D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin; D000086:Acetazolamide