Compounds binding to cytoskeletal proteins are active against Plasmodium falciparum in vitro.
The effects of nine different tubulin-binding substances and of one actin-binding compound, cytochalasin B, upon the intraerythrocytic development of the malaria parasite Plasmodium falciparum were investigated in vitro. From the data obtained, plasmodial tubulins seem to be quite different from the mammalian proteins on the molecular level. Tubulozole-T, a substance which is inactive in mammalian systems, appears to be a promising novel antimalarial drug.
Dieckmann-Schuppert
A
A
Dept. Structural Biology, University of Basel, Switzerland.
Franklin
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RM
D000199:Actins / Q000378:metabolism; D000470:Alkaloids / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001562:Benzimidazoles / Q000378:metabolism / Q000494:pharmacology*; D003571:Cytochalasin B / Q000378:metabolism / Q000494:pharmacology*; D003703:Demecolcine / Q000378:metabolism / Q000494:pharmacology; D004148:Dioxolanes / Q000378:metabolism / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology*; D004351:Drug Resistance; D010963:Plasmodium falciparum / Q000187:drug effects*; D014404:Tubulin / Q000378:metabolism; D014747:Vinblastine / Q000378:metabolism / Q000494:pharmacology; D014750:Vincristine / Q000378:metabolism / Q000494:pharmacology
D000199:Actins; D000470:Alkaloids; D001562:Benzimidazoles; D004148:Dioxolanes; D004149:Dioxoles; D014404:Tubulin; D003571:Cytochalasin B; D014750:Vincristine; C040422:tubulazole; D014747:Vinblastine; D003703:Demecolcine