title: Pharmacokinetic and pharmacodynamic principles of drug therapy in old age. Part 2.
abstract: In this Part 2, pharmacodynamic studies which have examined the possibility of true changes in drug "sensitivity" in old age are reviewed. In a variety of organ systems, age-related physiological changes are reflected in altered drug responsiveness in the elderly. Also, a better understanding of different pathophysiological background of disease in this age group leads to a more rational pharmacotherapeutic approach, which is exemplified in the recent drug therapy of hypertension in the elderly.
authors.affiliation: Department of Pharmacology, Yamanashi Medical College, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Tsujimoto
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: B B
authors.initials: BB
authors.lastname: Hoffman
mesh_terms: D000375:Aging / Q000378:metabolism*; D004358:Drug Therapy; D006801:Humans; D010599:Pharmacokinetics