Identification of the target platelet glycoprotein in autoimmune thrombocytopenia occurring after allogeneic bone marrow transplantation.
We report the case of a patient who developed autoimmune thrombocytopenia after allogeneic bone marrow transplantation from her HLA-identical sister. An IgG autoantibody was detected that bound to the platelet glycoprotein IIb/IIIa and to the HLA class I proteins. Immunoprecipitation studies with radiolabeled platelets revealed additional antibody binding sites on proteins of 214 kDa molecular weight under nonreduced conditions and 65 and 56 kDa molecular weight under reduced conditions.
Benda
H
H
Division of Hematology and Blood Coagulation, University of Vienna, Austria.
Panzer
S
S
Kiefel
V
V
Mannhalter
C
C
Hinterberger
W
W
Lechner
K
K
Mueller-Eckhardt
C
C
D000328:Adult; D000961:Antilymphocyte Serum / Q000032:analysis; D001327:Autoimmune Diseases / Q000097:blood* / Q000209:etiology; D001792:Blood Platelets / Q000032:analysis / Q000276:immunology; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D010980:Platelet Membrane Glycoproteins / Q000032:analysis* / Q000276:immunology; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology; D013921:Thrombocytopenia / Q000097:blood* / Q000209:etiology
D000961:Antilymphocyte Serum; D010980:Platelet Membrane Glycoproteins