[Fundamental study of a local drug delivery system by means of intracanal medication. Influence of iontophoresis on the periphery of the root surface].
The purpose of this study was to evaluate a new system of drug delivery to periodontal pocket by means of intracanal dressing and additional iontophoresis in vitro. Forty extracted human teeth with a single root were used. After the root canal was prepared endodontically, the periphery root apex was painted with the Silux system (3 M Co.) to close the apical foramen. Each tooth was planted into an agar block. Three drugs (zinc iodide-iodine, penicillin G. potassium, minocycline HCl) were used (Table 1), and 50 microliters of each drug was injected into an individual root canal. Then a cathodic current (3 mA x 40 min) was applied using an automatic current volte regulater (PAV-200, Jooko Co.) with a platinum wire electrode inserted in the root canal (Fig. 1). The degree of drugs diffusion in the agar around teeth was estimated by individual color reactions zinc iodide-iodin test for starch, penicillin G. potassium test for phosphomolybdic acid, minocycline HCl test for ferric chloride). And also, the effects of root planing and etching by Quick Jet (Yosida Co.) on the root surface were evaluated in the same way. The results were as follow: 1. The degree of diffusion by intracanal electrical medication was greater in the cervical third area than the middle and apical third. 2. Several small areas stained by the iodo-starch color reaction were observed around the cervical root surface where greater diffusion was observed. 3. Many dentinal tubules were observed on a limited root surface where root planing and Quick Jet, were employed caused greater diffusion. 4. The results suggest the new delivery system for management of the microorganisms by intracanal medication and additional iontophoresis.
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D006801:Humans; D007454:Iodides / Q000008:administration & dosage*; D007478:Iontophoresis; D008911:Minocycline / Q000008:administration & dosage*; D010400:Penicillin G / Q000008:administration & dosage*; D010514:Periodontal Pocket / Q000188:drug therapy*; D010518:Periodontitis / Q000188:drug therapy*; D012390:Root Canal Therapy / Q000379:methods*; D013754:Tetracyclines / Q000008:administration & dosage*; D014092:Tooth Root; D015032:Zinc / Q000008:administration & dosage*; D017967:Zinc Compounds
D007454:Iodides; D013754:Tetracyclines; D017967:Zinc Compounds; C029770:zinc iodide; D008911:Minocycline; D015032:Zinc; D010400:Penicillin G