title: Fatal hepatitis B reactivation after autologous bone marrow transplantation.
abstract: We report a fatal case of hepatitis B reactivation following autologous bone marrow transplantation for acute lymphocytic leukaemia. The presence of antibodies to HBs and HBc at presentation indicated previous infection with hepatitis B; these antibodies disappeared during the course of treatment for leukaemia. HBsAg was first detected in serum 5 weeks post-transplant; liver function tests began to deteriorate 8 weeks later, when HBeAg was first detected. The hepatitis followed a fulminant course, and the patient died 10 days later, in the 15th week following transplant.
authors.affiliation: Department of Virology, Royal Free Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Webster
authors.forename: M K
authors.initials: MK
authors.lastname: Brenner
authors.forename: H G
authors.initials: HG
authors.lastname: Prentice
authors.forename: P D
authors.initials: PD
authors.lastname: Griffiths
mesh_terms: D000293:Adolescent; D016026:Bone Marrow Transplantation; D002353:Carrier State / Q000209:etiology / Q000401:mortality; D005260:Female; D006509:Hepatitis B / Q000209:etiology* / Q000401:mortality; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000601:surgery; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality; D014182:Transplantation, Autologous / Q000401:mortality; D014775:Virus Activation