[Lymphocyte subpopulations in multiple sclerosis (MS). A contribution].
The characterization of peripheral blood T-cell subpopulations in 29 multiple sclerosis (MS) patients is studied. A direct immunofluorescence assay was performed using monoclonal antibodies (OK series) directed to lymphocytes surface antigens. In transverse study, the patients suffering from progressive MS showed T4+ lymphocytes and T4+/T8+ ratio significantly high (p less than 0.05) compared to controls; furthermore T8+ lymphocyte values were low. T3+ lymphocytes were low (p less than 0.05) during the relapse in the MS remitting relapsing patients. A six month follow-up of the patients showed, during relapse, a reduction and, immediately after, a recovery of T3+ and T4+ lymphocyte values; T8+ lymphocytes didn't show remarkable fluctuations.
Nuccetelli
F
F
Università degli Studi di Chieti, Clinica Neurologica.
Assetta
M
M
Tartaro
A
A
Di Muzio
A
A
Nanni Costa
E
E
Anichini
M
M
Gambi
D
D
D000328:Adult; D000911:Antibodies, Monoclonal; D002908:Chronic Disease; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology* / Q000628:therapy; D012008:Recurrence; D012074:Remission Induction; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
D000911:Antibodies, Monoclonal
Le sottopopolazioni linfocitarie nella sclerosi multipla (SM). Un contributo.