title: Extracellular matrix of the skin: 50 years of progress.
abstract: The extracellular connective tissue matrix of the skin is a complex aggregate of distinct collagenous and non-collagenous components. Optimal quantities and delicate interactions of these components are necessary to maintain normal physiologic properties of skin. This overview summarizes the progress made in understanding the normal biology and biochemistry of the extracellular matrix, and will highlight cutaneous diseases with underlying molecular defects in the structure and expression of extracellular matrix components.
authors.affiliation: Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: J
authors.initials: J
authors.lastname: Uitto
authors.forename: D R
authors.initials: DR
authors.lastname: Olsen
authors.forename: M J
authors.initials: MJ
authors.lastname: Fazio
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000502:physiology; D003094:Collagen / Q000502:physiology; D003880:Dermatology / Q000266:history; D004547:Elastic Tissue / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology*; D049673:History, 20th Century; D006801:Humans; D012879:Skin Physiological Phenomena
chemical_list: D003094:Collagen