[Side effects of dissolved and lyophilized cisplatin in the treatment of 133 head and neck tumors].
The authors have studied the side effects of a lyophilized and a dissolved cisplatin preparation in 133 patients with head and neck tumors. After intraarterial treatment (30 mg/24 hours) with dissolved cisplatin no nausea was observed, while treatment with lyophilized cisplatin was followed by nausea in rare cases (33%). Systemic treatment with dissolved cisplatin (50 mg/die) was associated with vomiting far less frequently (37%) than lyophilized cisplatin (90%). Metoclopramide was found to reduce these side effects.
Szabó
G
G
Fülöp
E
E
Jancsó
J
J
D002945:Cisplatin / Q000627:therapeutic use*; D005260:Female; D005612:Freeze Drying; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male
D002945:Cisplatin
Nebenwirkungen von gelöstem und lyophilisiertem Cisplatin bei der Behandlung von 133 Tumoren im Kopf-Hals-Bereich.