title: Intraoperative hemodynamic modifications during pediatric orthotopic liver transplantation.
abstract: OLT is generally associated with important cardiovascular changes occurring during the vascular clamping and at the time of revascularization of the newly transplanted liver. In our series of 60 OLT performed in 52 children, the IVC clamping is generally followed by a fall in the PAP and the PWP, the SBP remaining fairly stable in half of the cases. This good tolerance is confirmed by the fact that a veno-venous bypass was used only in 3 instances and vasopressive drugs were needed in only 6 cases. At unclamping, a severe decrease in SBP is associated with a sharp rise in PAP and PWP in most of the cases, whereas some hypovolemic patients decrease their SBP, PAP and PWP. Therefore, we believe that adequate fluid replacement under careful monitoring of the filling pressures provides a good hemodynamic stability in most of the children during the different stages of OLT.
authors.affiliation: Department of Anesthesiology, University of Louvain, Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Carlier
authors.forename: L
authors.initials: L
authors.lastname: van Obbergh
authors.forename: F
authors.initials: F
authors.lastname: Veyckemans
authors.forename: J L
authors.initials: JL
authors.lastname: Scholtes
authors.forename: J M
authors.initials: JM
authors.lastname: Gouverneur
authors.forename: B F
authors.initials: BF
authors.lastname: Gribomont
authors.forename: D
authors.initials: D
authors.lastname: Moulin
authors.forename: M
authors.initials: M
authors.lastname: Reynaert
authors.forename: B
authors.initials: B
authors.lastname: de Hemptinne
authors.forename: J B
authors.initials: JB
authors.lastname: Otte
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005440:Fluid Therapy; D006439:Hemodynamics; D006801:Humans; D007022:Hypotension / Q000188:drug therapy / Q000209:etiology; D007223:Infant; D007432:Intraoperative Period; D016031:Liver Transplantation; D011669:Pulmonary Wedge Pressure; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D014662:Vasoconstrictor Agents