title: Molecular genetics of lymphoid tumorigenesis.
abstract: The body of this work illustrates the utility of the combined cytogenetic and molecular approach to lymphoid tumorigenesis. A number of tumor-specific translocations have proven amenable to dissection by molecular techniques. We have a firm grasp of the general principles that underlie lymphoid neoplasia; in particular, the activation of cellular oncogenes by translocation into genes of the immunoglobulin superfamily is a widespread phenomenon. However, numerous lymphopoietic malignancies are only poorly understood. These remain a challenge for the continued application of these methodologies.
authors.forename: F G
authors.initials: FG
authors.lastname: Haluska
authors.forename: Y
authors.initials: Y
authors.lastname: Tsujimoto
authors.forename: G
authors.initials: G
authors.lastname: Russo
authors.forename: M
authors.initials: M
authors.lastname: Isobe
authors.forename: C M
authors.initials: CM
authors.lastname: Croce
mesh_terms: D001483:Base Sequence; D002051:Burkitt Lymphoma / Q000235:genetics; D002503:Centromere; D004247:DNA / Q000235:genetics; D006801:Humans; D008223:Lymphoma / Q000235:genetics*; D008969:Molecular Sequence Data; D014178:Translocation, Genetic
chemical_list: D004247:DNA