[A histochemical and ultrastructural study of nemaline myopathy (case report)].
Nemaline myopathy is characterized by presence of nemaline body or rod-like body within muscle fibers. Biopsy from a 7-year boy showed that rod-like bodies were present in most muscle fibers particularly in those atrophied type I fibers. The specificity of oxidase activity was increased with decrease of ATP and AMP activities as well as the intensity of PAS staining. EM observation showed that the rod-like bodies started from Z line and were similar to the lattice structure of Z line but somewhat more compact. The histochemical characteristics, innervation of rod-like body, clinic subtypes and genetic features of this disease were reviewed.
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D001706:Biopsy; D002648:Child; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D009123:Muscle Hypotonia / Q000473:pathology; D009132:Muscles / Q000648:ultrastructure*; D009135:Muscular Diseases / Q000151:congenital* / Q000473:pathology