Interferon alpha induced and maintained complete remission in chronic granulocytic leukemia in relapse after bone marrow transplantation.
We describe a patient with chronic granulocytic leukaemia (CGL) who relapsed after allogeneic bone marrow transplantation (BMT). Interferon alpha 2b (IFN alpha 2b) induced and maintained a complete remission. IFN alpha 2b led to full restoration of donor bone marrow. This case provides evidence to support a trial of IFN alpha in patients with relapsing CGL after BMT.
Borgies
P
P
Department of Haematology, Cliniques Universitaires St-Luc, Brussels, Belgium.
Ferrant
A
A
Delannoy
A
A
Van den Berghe
H
H
Michaux
J L
JL
D000328:Adult; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D006085:Graft Survival / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007370:Interferon Type I / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D008297:Male; D011994:Recombinant Proteins; D012074:Remission Induction; D014184:Transplantation, Homologous
D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D006918:Hydroxyurea