Tumor induction in mice administered neonatally with 1,2-dimethylhydrazine.
1,2-Dimethylhydrazine was given subcutaneously to neonatal ICR mice, and animals were observed for one year. The tumors of lung and liver, malignant lymphoma, and other tumors were induced. In the mice given DMH 30 mg/kg of body weight, two mice developed colonic tumor, and the incidence of colonic tumor was low.
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D019813:1,2-Dimethylhydrazine; D000818:Animals; D000831:Animals, Newborn; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000139:chemically induced; D004127:Dimethylhydrazines / Q000633:toxicity*; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008223:Lymphoma / Q000139:chemically induced; D008297:Male; D008763:Methylhydrazines / Q000633:toxicity*; D051379:Mice; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D015996:Survival Rate
D002273:Carcinogens; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D019813:1,2-Dimethylhydrazine