title: Effect of glipizide on the surgically altered pancreas.
abstract: Surgical alterations of the pancreas affect peripheral glucose, insulin, and glucagon levels with accompanying changes in carbohydrate metabolism. The sulfonylurea glipizide has been used to treat insulin-deficient states; however, its mechanism is not completely known. We hypothesized that glipizide would correct postoperative changes in glucose handling in a way that would allow more complete understanding of the drug's action. Two surgical groups (Group 1:80 percent proximal pancreatectomy; Group 2: proximal pancreatectomy plus splenocaval diversion) were compared with a healthy control group (Group 3). We have concluded that glipizide may have affected basal insulin sensitivity in the control group and Group 2 animals without affecting insulin secretion in response to oral or intravenous glucose stimulation. Glipizide does not correct the alterations in glucose handling or insulin secretion after reduction in beta-cell mass.
authors.affiliation: Department of Surgery, University of Virginia Medical Center, Charlottesville 22908.
authors.forename: J D
authors.initials: JD
authors.lastname: Barr
authors.forename: E S
authors.initials: ES
authors.lastname: Parish
authors.forename: D A
authors.initials: DA
authors.lastname: Krusch
authors.forename: A H
authors.initials: AH
authors.lastname: Farris
authors.forename: A H
authors.initials: AH
authors.lastname: Freedlender
authors.forename: D L
authors.initials: DL
authors.lastname: Kaiser
authors.forename: J B
authors.initials: JB
authors.lastname: Hanks
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D005913:Glipizide / Q000494:pharmacology*; D005934:Glucagon / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D007328:Insulin / Q000378:metabolism; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010180:Pancreatectomy; D013453:Sulfonylurea Compounds / Q000494:pharmacology*
chemical_list: D007328:Insulin; D013453:Sulfonylurea Compounds; D005934:Glucagon; D005947:Glucose; D005913:Glipizide