ras oncogene expression and prognosis of invasive squamous cell carcinomas of the uterine cervix.
By using anti-ras p21 mouse monoclonal antibody rp35, the authors studied the reactivity of 170 squamous cell carcinomas of the uterine cervix of different histologic types. The overexpression of p21 was noted in 57.1% of keratinizing type (K type) and 54.2% of large cell nonkeratinizing type (LNK type), but only 38.7% of small cell type (S type). Upon statistical analysis of the correlations between p21 overexpression and patient prognosis with the Kaplan-Meier method and generalized Wilcoxon text, the p21-positive K and LNK types showed poorer prognosis, whereas the positive S type showed better prognosis in comparison with the negative cases. These findings suggest that the expression of ras p21 is one of the parameters related with prognosis of cervical cancers, but the mode of the correlation is dependent on their histologic types.
Sagae
S
S
Department of Obstetrics and Gynecology, Sapporo Medical College, Japan.
Kuzumaki
N
N
Hisada
T
T
Mugikura
Y
Y
Kudo
R
R
Hashimoto
M
M
D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000032:analysis* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008565:Membrane Proteins / Q000032:analysis*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009857:Oncogenes; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D016283:Proto-Oncogene Proteins p21(ras); D002583:Uterine Cervical Neoplasms / Q000032:analysis* / Q000473:pathology
D000911:Antibodies, Monoclonal; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)