[Ion pair HPLC determination of p-aminobenzoic acid as an impurity in procaine and procainamide hydrochlorides].
A simple, specific and sensitive high-performance liquid chromatographic method for the determination of p-amino benzoic acid (PABA) as impurity in procaine and procainamide hydrochlorides has been developed. The compounds were chromatographed on reversed phase C-18 using water-methanol-acetonitrile solvent system containing sodium lauryl sulphate ion-pair reagent.
Maurich
V
V
Istituto di Tecnica Farmaceutica, Università degli Studi, Trieste.
Collino
F
F
Zacchigna
M
M
Moneghini
M
M
D010129:4-Aminobenzoic Acid / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D011342:Procainamide / Q000032:analysis*; D011343:Procaine / Q000032:analysis*
D011343:Procaine; D011342:Procainamide; D010129:4-Aminobenzoic Acid
Determinazione dell'acido p-amino-benzoico quale impurezza nei cloridrati di procaina e procainamide mediante HPLC a coppia ionica.