Repair kinetics in tissues: alternative models.
Monoexponential repair kinetics is based on the assumption of a single, dose-independent rate of repair of sublethal injury in the target cells for tissue injury after exposure to ionizing radiation. Descriptions of the available data based on this assumption have proved fairly successful for both acutely responding (skin, lip mucosa, gut) and late-responding (lung, spinal cord) normal tissues. There are indications of biphasic exponential repair in both categories, however. Unfortunately, the data usually lack sufficient resolution to permit unambiguous determination of the repair rates. There are also indications that repair kinetics may depend on the size of the dose. The data are conflicting on this account, however, with suggestions of both faster and slower repair after larger doses. Indeed, experiments that have been explicitly designed to test this hypothesis show either no effect (gut, spinal cord), faster repair after higher doses (lung, kidney), or slower repair after higher doses (skin). Monoexponential repair appears to be a fairly accurate description that provides an approximation to a more complicated picture, the elucidation of whose details will, however, require very careful and extensive experimental study.
Thames
H D
HD
Department of Biomathematics, University of Texas System Cancer Center, Houston 77030.
D000818:Animals; D004247:DNA / Q000528:radiation effects*; D004260:DNA Repair / Q000528:radiation effects*; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental; D011839:Radiation, Ionizing; D011878:Radiotherapy / Q000379:methods; D013997:Time Factors
D004247:DNA