title: Liver function and plasma protein metabolism in rodent model of filariasis.
abstract: Rodent model of filariasis was developed by infecting Wistar rats with Litomosoides carinii. Liver function tests, plasma protein concentrations, and synthesis rates of liver-formed proteins were estimated in these rats at 63 and 90 days post-infection. At 63 days post-infection, aspartate aminotransferase and alkaline phosphatase were significantly increased. Alanine aminotransferase, plasma total proteins and plasma albumin were in the normal range. However, at 90 days post-infection all these parameters were affected, reflecting progressive liver involvement. Hypoalbuminemia at 90 days post-infection did not appear to be due to decreased synthesis rate, indicating higher catabolism and/or altered distribution in pools.
authors.forename: G D
authors.initials: GD
authors.lastname: Nadkarni
authors.forename: U R
authors.initials: UR
authors.lastname: Deshpande
authors.forename: M K
authors.initials: MK
authors.lastname: Bhopale
mesh_terms: D000818:Animals; D003411:Arvicolinae; D001798:Blood Proteins / Q000378:metabolism*; D005368:Filariasis / Q000503:physiopathology*; D008099:Liver / Q000503:physiopathology*; D008109:Liver Diseases, Parasitic / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001798:Blood Proteins