The role of dopamine in the control of corticosteroid secretion and metabolism.
The relation between aldosterone and its trophins is altered by electrolyte status and in some hypertensive conditions in man by a mechanism or mechanisms not understood. Dopamine has been suggested as the agent for the altered sensitivity of plasma aldosterone to angiotensin II based on the results of studies with dopamine itself, both in vivo and in vitro, and with pharmacological agonists and antagonists. The evidence derived from these studies is presented and discussed. Questionable specificity of the agents used makes interpretation difficult. Similarly, dopamine infusion rates used in man and animals have resulted in plasma concentrations far in excess of those found normally and these pharmacological concentrations have been shown to alter both the clearance rate of exogenous angiotensin II, and the pattern of steroid response to ACTH. Direct study of adrenal tissue has provided more promising results. The adrenal cortex possesses specific dopamine receptors and dopamine has been shown to modify aldosterone biosynthesis in vitro. Moreover, dopamine is present in adrenocortical tissue in concentrations in the range calculated to operate the receptors. However, there is, as yet, no evidence that dopamine concentrations change in a physiological meaningful way, for example, during changes in sodium status.
Fraser
R
R
MRC Blood Pressure Unit, Western Infirmary, Glasgow, Scotland.
Connell
J M
JM
Inglis
G
G
Kenyon
C J
CJ
Tree
M
M
D000302:Adrenal Cortex / Q000502:physiology; D000305:Adrenal Cortex Hormones / Q000378:metabolism*; D000818:Animals; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D006801:Humans
D000305:Adrenal Cortex Hormones; D004298:Dopamine