title: Gastrointestinal scintigraphy with 99mTc-DTPA labeled tablets in fed and fasting subjects.
abstract: The in vitro and in vivo dissolution of a sustained release theophylline formulation labeled with 99mTc-diethyltriaminepentaacetic acid (DTPA) has been monitored in six subjects with a scintillation camera. The study was performed in fasting conditions and was repeated after ingestion of a standardized meal. Results showed that the presence of food in the stomach dramatically increased the oesoduodenal transit time of the tablet (74 +/- 27 min vs 352 +/- 77 min, P less than 0.001) but did not modify the biodisponibility of theophylline. This study is another example when scintigraphy can be of definite value in pharmacokinetics.
authors.affiliation: Division of Nuclear Medicine, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Maublant
authors.forename: M
authors.initials: M
authors.lastname: Sournac
authors.forename: J M
authors.initials: JM
authors.lastname: Aiache
authors.forename: A
authors.initials: A
authors.lastname: Veyre
mesh_terms: D000328:Adult; D003692:Delayed-Action Preparations; D004435:Eating; D005215:Fasting; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid; D013607:Tablets; D013667:Technetium; D016284:Technetium Tc 99m Pentetate
chemical_list: D003692:Delayed-Action Preparations; D009942:Organometallic Compounds; D013607:Tablets; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate