title: [Neuropathy caused by amiodarone: clinico-pathologic study of 2 cases].
abstract: Two patients, a 40-year-old woman and a 75-year-old man, were investigated due to a chronic polyneuritis. Amiodarone was used by them to treat refractory cardiac arrhythmia since 4 and 6 years before, respectively. The EMG study showed an axonal neuropathy. The light and electron-microscopical study of sural nerve displayed a loss of large myelinated fibers and a marked reduction of unmyelinated axons, associated with osmiophilic lamellated inclusions in Schwann cells and endothelial venulae. The interruption of amiodarone therapy improved neuropathy. Considered together with similar reports in perhexiline neuropathy and with chloroquine induced neuropathy this would stress the importance of these new drug-induced neurolipidosis.
authors.affiliation: Faculdade de Ciências Médicas da UNICAMP, Campinas SP, Brasil.
authors.forename: J A
authors.initials: JA
authors.lastname: Maciel Júnior
authors.forename: L
authors.initials: L
authors.lastname: Queiroz
mesh_terms: D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D001369:Axons / Q000648:ultrastructure; D001706:Biopsy; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D011115:Polyneuropathies / Q000139:chemically induced* / Q000473:pathology; D013127:Spinal Nerves; D013497:Sural Nerve
chemical_list: D000638:Amiodarone
vernacular_title: Neuropatia pela amiodarona: estudo clínico-patológico de dois casos.