title: Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891.
abstract: The most efficient routes for the synthesis of FCE 22101, a penem antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891, its orally absorbed pro-drug, are described. On the basis of in-vitro antimicrobial profile and other characteristics the compounds have been considered worthy of further development.
authors.affiliation: Farmitalia Carlo Erba, Research and Development, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Franceschi
authors.forename: E
authors.initials: E
authors.lastname: Perrone
authors.forename: M
authors.initials: M
authors.lastname: Alpegiani
authors.forename: A
authors.initials: A
authors.lastname: Bedeschi
authors.forename: C
authors.initials: C
authors.lastname: Battistini
authors.forename: F
authors.initials: F
authors.lastname: Zarini
authors.forename: C
authors.initials: C
authors.lastname: Della Bruna
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D015780:Carbapenems; D055598:Chemical Phenomena; D002621:Chemistry; D007769:Lactams
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D007769:Lactams; C041561:FCE 22891; C040033:ritipenem