Effect of long-term inhalation of N-nitroso-dimethylamine (NDMA) and SO2/NOx in rats.
This report focusses on preliminary results of a long-term inhalation assay with N-nitroso-dimethylamine (NDMA) at low concentrations. Chronic inhalation of 1 ppm of NDMA (4 h/day, 5 days/week) was found to be toxic in rats and diminished life expectancy by about 8 months compared to the control group. Mostly tumors of the nasal region (25/36) were observed. Inhalation of 0.2 ppm of NDMA lead to a high tumor yield in rats (20/36). At a concentration of 0.04 ppm (= 0.12 mg/m3 in air) 3 tumors of the nasal region have been found until now. In addition, a combined inhalation study of other air pollutants SO2 or NOx together with NDMA at the 0.2 ppm level is being performed. Tumors of the nasal region have been observed in the groups with SO2 + NDMA and NOx + NDMA as well as with NDMA alone. Differences in tumor response of the groups treated with NDMA alone or in combination with SO2/NOx cannot be assessed yet. The additional treatment with the air pollutants SO2 or NOx has not affected the body weight gain or any other observable parameters of the life quality of the rats.
Klein
R G
RG
Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
Janowsky
I
I
Schmezer
P
P
Hermann
R
R
Spiegelhalder
B
B
Zeller
W J
WJ
Pool
B L
BL
D000280:Administration, Inhalation; D000393:Air Pollutants / Q000633:toxicity; D000818:Animals; D004128:Dimethylnitrosamine / Q000008:administration & dosage / Q000009:adverse effects / Q000633:toxicity*; D005260:Female; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced / Q000473:pathology; D013458:Sulfur Dioxide / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors
D000393:Air Pollutants; D013458:Sulfur Dioxide; D004128:Dimethylnitrosamine