Rapid improvement of visual defects with parenteral depot-bromocriptine in a patient with a non-functioning pituitary adenoma.
The management of non-functioning pituitary adenomas with bromocriptine is controversial, and surgical treatment is usually prescribed when the visual field is affected. Here we report, what we believe to be the first case of a patient with a non-functioning pituitary adenoma who experienced normalization of visual field defects and a substantial improvement in visual acuity after the parenteral administration of depot-bromocriptine. The patient's tolerance to the drug was excellent. The results of the immunohistochemical study of the surgically removed tumor were negative for PRL, GH, LH, FSH, TSH and ACTH. In our opinion, the use of depot-bromocriptine may represent an alternative to surgery in patients with non-functioning pituitary adenomas associated with visual lesions.
García-Luna
P P
PP
Department of Pathology, Virgen del Rocio, University Hospital, Seville, Spain.
Leal-Cerro
A
A
Pereira
J L
JL
Montero
C
C
Acosta
D
D
Trujillo
F
F
Mazuelos
C
C
Astorga
R
R
D000236:Adenoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D001971:Bromocriptine / Q000008:administration & dosage* / Q000627:therapeutic use; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D011859:Radiography; D014792:Visual Acuity / Q000187:drug effects*; D014794:Visual Fields / Q000187:drug effects*
D003692:Delayed-Action Preparations; D001971:Bromocriptine