title: Effects of oral copper administration to pregnant heterozygous brindled mice on fetal viability and copper levels.
abstract: Copper (6 ppm) was administered to pregnant heterozygous brindled and normal mice from 13 to 18 days gestation. The copper and zinc concentrations in the cerebrum, cerebellum, liver, and kidneys of mothers and their fetuses were determined. The placental concentrations in fetuses of heterozygous mothers administered copper were also determined. The heterozygous mothers had smaller numbers of live fetuses than the normal mothers, but had the same number as normal mothers when copper was administered. The hepatic copper concentration in the heterozygous mothers was lower than that in the normal mothers and was not increased by the administration. The body and tissue wet weights of all fetuses were unaffected by the maternal genotype or drinking fluid. The cerebral copper concentrations in hemizygous and heterozygous fetuses were increased by the copper administration but did not reach normal levels. The hepatic and renal concentrations remained unchanged. The cerebral copper concentrations in normal fetuses of both heterozygous and normal mothers were increased by the copper administration. The copper administration increased the copper concentrations in liver of normal fetuses of heterozygous mothers and in kidneys of normal fetuses of normal mothers. The placental copper concentration in hemizygous fetuses was higher than those in heterozygous and normal fetuses. These results suggested that oral copper administration to pregnant females could improve an abnormal copper distribution in hemizygous and heterozygous fetuses without affecting fetal growth.
authors.affiliation: Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kasama
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D001835:Body Weight; D001921:Brain / Q000196:embryology / Q000378:metabolism; D001928:Brain Diseases, Metabolic / Q000196:embryology*; D002531:Cerebellum / Q000196:embryology / Q000378:metabolism; D003300:Copper / Q000378:metabolism / Q000627:therapeutic use*; D004326:Drinking; D005260:Female; D006579:Heterozygote; D007668:Kidney / Q000196:embryology / Q000378:metabolism; D008098:Litter Size; D008099:Liver / Q000196:embryology / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D007706:Menkes Kinky Hair Syndrome / Q000188:drug therapy / Q000196:embryology* / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D015032:Zinc / Q000378:metabolism
chemical_list: D003300:Copper; D015032:Zinc