A comparative trial of a new antidepressant, fluoxetine.
A double-blind clinical trial was undertaken to evaluate clinical efficacy and safety of fluoxetine in comparison with the standard tricyclic antidepressant, imipramine, in the treatment of depressive illness. The opportunity was taken to compare the relationship of some standard measures of depressive illness, two observer based--Hamilton Depression Rating Scale and the Montgomery-Asberg Depression Rating Scale (Montgomery and Asberg, 1979)--and a self-rating scale--Levine Pilowsky Depression questionnaire (Pilowsky et al., 1969).
Levine
S
S
Oldham General Hospital, U.K.
Deo
R
R
Mahadevan
K
K
D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007099:Imipramine / Q000009:adverse effects / Q000627:therapeutic use*; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales
D005473:Fluoxetine; D007099:Imipramine