Cardiac transplantation in the seventh decade of life.
Twenty-five patients older than 60 years of age underwent cardiac transplantation using an immunosuppression protocol with cyclosporin and azathioprine, but without routine use of oral steroids. There were 24 men and 1 woman (age range 60 to 69 years, mean 63). The etiology of heart disease was coronary artery disease in 21 and idiopathic dilated cardiomyopathy in 4. Six patients had previous coronary artery bypass operations, 1 had undergone repair of an abdominal aneurysm and 1 had pulmonary embolism. Sixteen patients were in New York Heart Association class IV and 9 in class III. Donor mean age was 30 (14 to 46) years. Hospital stay after transplantation was 10 to 90 days (median 11). Four died within 30 days and none from 5 to 59 months (mean 22). The 1-year actuarial survival was 84%. The incidence of rejection was 2.16 episodes per patient. Only 1 patient (4%) had serious infection. Six patients received antihypertensive treatment, 3 had reversible impairment of renal function, 2 had gout and 1 had drop foot. No patient had convulsions, transient ischemic attack or cerebrovascular accident. None had significant psychological problems. The 21 patients currently alive are in New York Heart Association class I. Quality of life, assessed by the Nottingham Health Profile, showed marked improvement. It is concluded that the initial results of cardiac transplantation in the seventh decade of life are encouraging.
Aravot
D J
DJ
Harefield Hospital, Middlesex, England.
Banner
N R
NR
Khaghani
A
A
Fitzgerald
M
M
Radley-Smith
R
R
Mitchell
A G
AG
Yacoub
M H
MH
D000206:Actuarial Analysis; D000368:Aged; D001379:Azathioprine / Q000627:therapeutic use; D002311:Cardiomyopathy, Dilated / Q000401:mortality / Q000601:surgery*; D003327:Coronary Disease / Q000401:mortality / Q000601:surgery*; D003524:Cyclosporins / Q000627:therapeutic use; D005260:Female; D006084:Graft Rejection; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011788:Quality of Life
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D001379:Azathioprine