The antihypoxic effect of ethymisole: a comparison with other nootropic drugs.
Ethymisole reveals a potent antihypoxic effect which is produced probably both by an acute free radical scavenging property and a persisting restitutive component of action. This is seen in its effect on posthypoxic inhibition of dopamine release from striatum slices of adult rats. Though ethymisole is considered a drug which increases brain adaptive potency, it does not modify the stimulus-response relation of potassium-evoked dopamine release in an adaptation-like manner, as it is seen after a long-lasting piracetam treatment.
Fischer
H D
HD
Institute of Pharmacology and Toxicology, Medical Academy, Carl Gustav Carus, Dresden, GDR.
Wustmann
C
C
Rudolph
E
E
Zaytsev YuV
Borodkin YuS
Schmidt
J
J
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005042:Etimizol / Q000494:pharmacology*; D000860:Hypoxia / Q000517:prevention & control*; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014665:Vasodilator Agents / Q000494:pharmacology; D014748:Vinca Alkaloids / Q000494:pharmacology
D007093:Imidazoles; D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C013983:vinpocetine; D005042:Etimizol; D004298:Dopamine; D010889:Piracetam