title: Human fetal liver as a valuable source of haemopoietic stem cells for allogeneic bone marrow transplantation.
abstract: The CFU-GM and T cell contents of human fetal livers were studied at various times between 6-14 weeks of gestation. The number of CFU-GM increased parallel to gestational age, especially after week 10. Cells bearing mature T cell markers, however, were found only in one case out of 35 fetal liver samples. Cryopreservation of fetal liver cells hardly affected the viability and proliferative capacity of CFU-GM in the sample. According to these findings fetal liver is, at least up to the 14th gestational week, practically free of mature T cells but it does contain a considerable amount of CFU-GM (an accepted indicator of pluripotent stem cell content), consequently fetal liver can be considered as a valuable source of haemopoietic stem cells for allogeneic bone marrow transplantation for children.
authors.affiliation: National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
authors.forename: D T
authors.initials: DT
authors.lastname: Phan
authors.forename: R
authors.initials: R
authors.lastname: Mihalik
authors.forename: M
authors.initials: M
authors.lastname: Benczur
authors.forename: K
authors.initials: K
authors.lastname: Pálóczi
authors.forename: J
authors.initials: J
authors.lastname: Gidáli
authors.forename: I
authors.initials: I
authors.lastname: Fehér
authors.forename: J
authors.initials: J
authors.lastname: Dömötöri
authors.forename: C
authors.initials: C
authors.lastname: Kiss
authors.forename: G G
authors.initials: GG
authors.lastname: Petrányi
authors.forename: K
authors.initials: K
authors.lastname: Natonek
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D016026:Bone Marrow Transplantation; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D005260:Female; D005615:Freezing; D006098:Granulocytes / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000196:embryology*; D006801:Humans; D008099:Liver / Q000196:embryology; D008264:Macrophages / Q000166:cytology; D011247:Pregnancy; D011309:Preservation, Biological; D013601:T-Lymphocytes / Q000166:cytology / Q000196:embryology*; D014184:Transplantation, Homologous
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte