[Multidomain structure of fibrinogen and its transformations].
Generalized concepts of some structural peculiarities of fibrinogen, its transformation into fibrin and assembly have been considered on the basis of author's and published data. The role of local conformational changes in different areas of fibrinogen molecule and of separate reaction centers in formation of single- and double-stranded rod-like equilibrium fibrin oligomers and flexible branched copolymers of fibrinogen with fibrin E fragment has been considered. The mechanism of compactization has been discussed.
Rozenfel'd
M A
MA
Gershkovich
K B
KB
D000818:Animals; D005337:Fibrin / Q000096:biosynthesis; D005338:Fibrin Fibrinogen Degradation Products / Q000096:biosynthesis; D005340:Fibrinogen / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D046911:Macromolecular Substances; D013329:Structure-Activity Relationship
D005338:Fibrin Fibrinogen Degradation Products; D046911:Macromolecular Substances; C011468:fibrinmonomer; D005337:Fibrin; D005340:Fibrinogen
Mul'tidomennaia struktura fibrinogena i ego prevrashcheniia.