title: Prostaglandin E2 gel for cervical ripening and induction of labor: a critical analysis.
abstract: This report summarizes the cumulative experience of 3313 pregnancies represented in 59 prospective clinical trials in which intracervical or intravaginal prostaglandin E2 gel was used for cervical ripening before induction of labor. Results indicate that local prostaglandin E2 is superior to placebo or no therapy in enhancing cervical effacement and dilation, reducing initial induction failures, shortening the induction-delivery interval, reducing oxytocin use, and lowering the rate of cesarean section because of failure to progress. Certain advantages also exist for labor induction in the presence of a favorable cervical state. Uterine hyperstimulation or pathologic fetal heart rate patterns before oxytocin administration occur in less than 1% of reported cases and are usually dose related, self contained, and reversible with the use of beta-adrenergic tocolytic therapy. Maternal systemic effects in these low doses are negligible. Worldwide clinical experience has clearly demonstrated that prostaglandin E2 gel administered before induction of labor is of major therapeutic benefit and should become commercially available for more than investigational use.
authors.affiliation: Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha 68105.
authors.forename: W F
authors.initials: WF
authors.lastname: Rayburn
mesh_terms: D002584:Cervix Uteri / Q000187:drug effects* / Q000502:physiology; D002986:Clinical Trials as Topic; D015232:Dinoprostone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005782:Gels; D006801:Humans; D007267:Injections; D007751:Labor, Induced; D011247:Pregnancy; D014621:Vagina
chemical_list: D005782:Gels; D015232:Dinoprostone