Effect of ethanol and stress on plasma catecholamines and their relation to changes in emotional state and performance.
The "tension reduction hypothesis" of ethanol was investigated with respect to stress- and ethanol-induced changes of plasma catecholamines and their relations to changes in emotional state and performance. Twenty-two healthy male volunteers were tested under the influence of 0.8 g/kg ethanol and compared to 22 matched controls receiving a placebo drink. Stress was induced by mental arithmetic applied prior to and 45 min after fluid consumption. Plasma epinephrine (E) and norepinephrine (NE) obtained from an indwelling cannula inserted 50 min prior to stress application were determined prior to and after each stress session. Percentage changes were compared within and between groups and correlated with respective changes of emotional states and performance in mental arithmetic. While ethanol decreased performance and stress-related emotional arousal, it did not affect stress-induced changes in plasma catecholamines. Rather, the fluid (ethanol as well as placebo) increased NE levels. Emotional tension reduction was associated with low resting or average levels of E in the placebo group but this relationship was disrupted by ethanol. High NE resting levels and drink induced increases predicted emotional tension reduction with placebo but an increase in stress induced depression with alcohol. "Biochemical tension reduction" (represented by both reduced E and NE stress response) may be predicted from generally lower levels of activation and elation by alcohol but not with the placebo condition. Although performance was positively related to low NE resting levels and stress responses, no influence of alcohol on this relationship was observed.(ABSTRACT TRUNCATED AT 250 WORDS)
Vogel
W H
WH
Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Netter
P
P
D000293:Adolescent; D000328:Adult; D002395:Catecholamines / Q000097:blood*; D004644:Emotions / Q000187:drug effects*; D004837:Epinephrine / Q000097:blood; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011597:Psychomotor Performance / Q000187:drug effects*; D011674:Pulse / Q000187:drug effects; D013315:Stress, Psychological / Q000097:blood*
D002395:Catecholamines; D000431:Ethanol; D009638:Norepinephrine; D004837:Epinephrine