[Serum beta 2-microglobulin and ankylosing spondylitis].
The serum beta-2-microglobulin (B2-m) was evaluated by radio-immunoassay in 28 patients with ankylosing spondylarthritis. The mean B2-m level is within normal limits. There is no overall correlation with other biological or immunological parameters (Sed Rate, IgA, CD3+, CD4+, CD8+, Leu 7, NK activity). There is no difference between treated and untreated patients, between patients with recent or old disease. On the contrary, the mean the mean B2-m level is significantly lower in patients B27 positive, as compared with B27 negative. The possible role of anti-B2-m antibodies interfering with the serum B2-m assay discussed.
Wendling
D
D
Service de Rhumatologie, Hôpital J.-Minjoz, Besançon.
Mas
J
J
Chatelain
F
F
Guidet
M
M
D000328:Adult; D005260:Female; D015235:HLA-B Antigens / Q000032:analysis; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D013167:Spondylitis, Ankylosing / Q000097:blood*; D001613:beta 2-Microglobulin / Q000032:analysis*
D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D001613:beta 2-Microglobulin
Bêta-2-microglobuline sérique et spondylarthrite ankylosante.