title: Evaluation of preoperative hematology-coagulation screening in liver transplantation.
abstract: We retrospectively reviewed the results of preoperative hematology-coagulation studies in 66 patients who underwent orthotopic liver transplantation-24 with the primary diagnosis of chronic active hepatitis (CAH), 22 with primary sclerosing cholangitis (PSC), and 20 with primary biliary cirrhosis (PBC). The mean prothrombin time was above normal in all three diagnostic groups, patients with CAH having the highest values. The mean activated partial thromboplastin time was normal in patients with PSC or PBC but elevated in those with CAH. Fibrinogen levels were above normal in patients with PBC but decreased in 1 patient (5%) with PSC and 10 (42%) with CAH. Mean platelet counts were below normal in 68% and 55% of patients with PSC and PBC, respectively, but in 96% of those with CAH. The mean Ivy bleeding time was normal in patients with PSC or PBC but prolonged in those with CAH. Patients with PSC or PBC had normal mean activity levels of factors II, V, VII, IX, and X, whereas those with CAH had below normal mean values for factors II and VII. The antithrombin III activity level was normal in patients with PSC or PBC but reduced in those with CAH. Thus, patients with CAH have a greater derangement in results of clotting studies in comparison with those who have PSC or PBC, but the use of blood did not differ among the three diagnostic groups.
authors.affiliation: Department of Anesthesiology, Emory University Hospital, Atlanta, Georgia.
authors.forename: D M
authors.initials: DM
authors.lastname: Ritter
authors.forename: C A
authors.initials: CA
authors.lastname: Owen
authors.forename: E J
authors.initials: EJ
authors.lastname: Bowie
authors.forename: S R
authors.initials: SR
authors.lastname: Rettke
authors.forename: T L
authors.initials: TL
authors.lastname: Cole
authors.forename: H F
authors.initials: HF
authors.lastname: Taswell
authors.forename: D M
authors.initials: DM
authors.lastname: Ilstrup
authors.forename: R H
authors.initials: RH
authors.lastname: Wiesner
authors.forename: R A
authors.initials: RA
authors.lastname: Krom
mesh_terms: D000990:Antithrombin III / Q000378:metabolism; D001660:Biliary Tract Diseases / Q000097:blood / Q000601:surgery; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000032:analysis; D017707:Erythrocyte Transfusion; D006521:Hepatitis, Chronic / Q000097:blood / Q000601:surgery; D006801:Humans; D016031:Liver Transplantation; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011300:Preoperative Care; D011517:Prothrombin Time; D012189:Retrospective Studies
chemical_list: D001779:Blood Coagulation Factors; D000990:Antithrombin III