title: Clonazepam treatment of five lithium-refractory patients with bipolar disorder.
abstract: The authors describe the first five patients enrolled in an open clinical trial of clonazepam as a maintenance treatment in lithium-refractory bipolar disorder. All patients relapsed quickly after taking clonazepam (one within 2 weeks and four within 10-15 weeks), and the study was prematurely terminated. The results cast doubt over the usefulness of clonazepam as a prophylaxis in lithium-resistant bipolar patients who have histories of psychotic mania or delusional depression.
authors.affiliation: Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook 11794-8101.
authors.forename: T A
authors.initials: TA
authors.lastname: Aronson
authors.forename: S
authors.initials: S
authors.lastname: Shukla
authors.forename: J
authors.initials: J
authors.lastname: Hirschowitz
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D002986:Clinical Trials as Topic; D002998:Clonazepam / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012008:Recurrence
chemical_list: D002998:Clonazepam; D008094:Lithium