Protection of mice against vaccinia and herpes simplex virus infection by Propionibacterium acnes.
Heat-killed cell suspension of several Propionibacterium acnes strains were prepared and studied for their protective activity in viral infection of mice and immunomodulating properties. Majority of the strains caused marked spleen enlargement in the treated mice. These changes persisted for several weeks. Only some of the tested strains enhanced significantly primary humoral immune response against sheep red blood cells. There was no increase, however, in neutralizing or hemagglutination-inhibition antibody production against vaccinia virus in mice treated with Propionibacteria. No evidence in the increase of spleen lymphocytes migration inhibition of mice infected with vaccinia virus and treated with P. acnes or in hypersensitivity reaction to oxazolone have been found. Significant resistance enhancement of mice pretreated with P. acnes against vaccinia virus or herpes simplex virus type 1 infection was observed. Activity of Propionibacteria depended on the applied strain, dose and scheme of administration.
Zgórniak-Nowosielska
I
I
Department of Virology, Medical Academy, Cracow.
Cwik
D
D
Sławińska
B
B
D000818:Animals; D005260:Female; D006561:Herpes Simplex / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*; D007114:Immunization; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D011425:Propionibacterium acnes / Q000276:immunology*; D013154:Spleen / Q000276:immunology / Q000503:physiopathology*; D014615:Vaccinia / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*