title: Systolic hypertension in the elderly. Relationship with cardiovascular disease.
abstract: The risk of stroke and myocardial infarction is increased in patients with elevated systolic blood pressure. Although treatment trials have demonstrated the benefit of antihypertensive therapy in elderly patients with diastolic hypertension, the only trial conducted in elderly patients with isolated systolic hypertension is currently in progress. A six-month trial of nonpharmacologic therapy should generally be the initial treatment in patients with isolated systolic hypertension. Then, if systolic pressure remains elevated, a cautious trial of drug treatment is reasonable. The drug used should be started in a low dose, and the dose should be titrated slowly. With this approach, antihypertensive treatment of elderly patients with isolated systolic hypertension may be well tolerated and ultimately beneficial.
authors.affiliation: Department of Heart and Hypertension, Cleveland Clinic Foundation, OH 44195-5069.
authors.forename: M D
authors.initials: MD
authors.lastname: Cressman
authors.forename: R W
authors.initials: RW
authors.lastname: Gifford
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001795:Blood Pressure Determination; D002318:Cardiovascular Diseases / Q000150:complications*; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013599:Systole
chemical_list: D000959:Antihypertensive Agents