title: Structure and expression of the Plasmodium falciparum SERA gene.
abstract: Plasmodium falciparum, strain FCR3, genomic DNA that encodes the SERA gene of P. falciparum was isolated and sequenced. The SERA gene coding region was interrupted by 3 introns, the largest number observed, so far, in any Plasmodium gene. Two SERA gene alleles, allele I and allele II, were identified in the FCR3 strain, while only allele I was found in the Honduras-1 strain. Allele I mRNA was abundant in vivo during the late trophozoite and schizont stages. Allele II mRNA was either not expressed, or it was labile.
authors.affiliation: Department of Microbiology, Dartmouth Medical School, Hanover, NH 03756.
authors.forename: W B
authors.initials: WB
authors.lastname: Li
authors.forename: D J
authors.initials: DJ
authors.lastname: Bzik
authors.forename: T
authors.initials: T
authors.lastname: Horii
authors.forename: J
authors.initials: J
authors.lastname: Inselburg
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000235:genetics* / Q000302:isolation & purification; D001483:Base Sequence; D015152:Blotting, Northern; D015139:Blotting, Southern; D003001:Cloning, Molecular; D004247:DNA; D005091:Exons; D005796:Genes; D007438:Introns; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000138:chemical synthesis; D010963:Plasmodium falciparum / Q000235:genetics*; D012326:RNA Splicing; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
chemical_list: D000953:Antigens, Protozoan; D009841:Oligonucleotides; D012333:RNA, Messenger; D004247:DNA