title: Ischemia of the femoral head in Perthes' disease: is the cause intra- or extravascular?
abstract: We examined selected parameters of the clotting and fibrinolytic system of 26 boys with aseptic necrosis of the femoral head and then evaluated the pressure of the fluid in the cavity of the hip joint with the help of ultrasonic examination. No disturbances were discovered in the coagulation system and ultrasonography ruled out the possibility that extravascular pressure had caused the necrosis. We confirmed a significantly greater level of alpha 1-antitrypsin in comparison with the control group, which may indicate a decrease in fibrinolytic activity and confirm the hypothesis that there is an intravascular pre-disposition towards the appearance of clots in the vascular system of the femoral head in patients with Perthes' disease.
authors.affiliation: Pediatric Orthopaedic Clinic, Pediatric Institute, Lublin, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Gregosiewicz
authors.forename: M
authors.initials: M
authors.lastname: Okoński
authors.forename: D
authors.initials: D
authors.lastname: Stołecka
authors.forename: G
authors.initials: G
authors.lastname: Kandzierski
authors.forename: M
authors.initials: M
authors.lastname: Szponar
mesh_terms: D001780:Blood Coagulation Tests; D002648:Child; D002675:Child, Preschool; D005270:Femur Head / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D005271:Femur Head Necrosis / Q000503:physiopathology*; D005342:Fibrinolysis; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D007873:Legg-Calve-Perthes Disease / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D013582:Synovial Fluid / Q000473:pathology; D014463:Ultrasonography; D000515:alpha 1-Antitrypsin / Q000378:metabolism
chemical_list: D000515:alpha 1-Antitrypsin