Pharmacokinetic data of propranolol enantiomers in a comparative human study with (S)- and (R,S)-propranolol.
The pharmacokinetics of (S)-propranolol were compared after the oral administration of a 40 mg dose of the pure enantiomer and an 80 mg dose of a racemic mixture of (R,S)-propranolol. The results of this study indicate that the bioavailability of (S)-propranolol, as expressed by the mean area under the concentration-time curve (AUC) and maximum serum concentration, is lower after 40 mg of the optically pure drug than after the racemic drug.
Lindner
W
W
Institute of Pharmaceutical Chemistry, Karl-Franzens-University of Graz, Austria.
Rath
M
M
Stoschitzky
K
K
Semmelrock
H J
HJ
D000328:Adult; D001682:Biological Availability; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D011433:Propranolol / Q000493:pharmacokinetics*; D013237:Stereoisomerism
D011433:Propranolol