title: Ceftriaxone single dose versus ceftazidime multiple doses in the prophylaxis of infection in colorectal surgery.
abstract: Sixty patients admitted to the hospital for colorectal surgery were randomly assigned to prophylaxis either with a single dose of ceftriaxone (Rocephin) i.v. plus metronidazole given 30 min prior to induction of anesthesia or with multiple doses of ceftazidime plus metronidazole given repeatedly every 8 h up to 24 h after surgery. The overall number of infections observed with the long-acting cephalosporin ceftriaxone was 4 (2 local and 2 remote), with the short-acting ceftazidime the number was 9 (5 local and 4 remote). Neither regimen was associated with adverse reactions.
authors.affiliation: Santa Marta Hospital (Hospitais Civis de Lisboa), Department of Surgery, Lisbon, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Palla Garcia
authors.forename: J
authors.initials: J
authors.lastname: Consiglieri Pedroso
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000517:prevention & control; D002442:Ceftazidime / Q000008:administration & dosage / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003106:Colon / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D012007:Rectum / Q000601:surgery*
chemical_list: D002443:Ceftriaxone; D002442:Ceftazidime