title: Cerebrospinal fluid beta 2 microglobulin in patients infected with human immunodeficiency virus.
abstract: We prospectively evaluated CSF concentrations of beta 2 microglobulin (beta 2M) in 65 human immunodeficiency virus type 1 seropositive patients. The highest concentrations occurred in those with lymphoma, neurologic opportunistic infections, and acquired immune deficiency syndrome dementia complex (ADC). There was a high correlation between the CSF beta 2M concentration and ADC severity, suggesting that CSF beta 2M may be useful as a marker for the development, progression, and perhaps response to treatment of ADC. Elevated CSF beta 2M was not due to CSF pleocytosis and was usually independent of blood-brain barrier dysfunction.
authors.affiliation: Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: B J
authors.initials: BJ
authors.lastname: Brew
authors.forename: R B
authors.initials: RB
authors.lastname: Bhalla
authors.forename: M
authors.initials: M
authors.lastname: Fleisher
authors.forename: M
authors.initials: M
authors.lastname: Paul
authors.forename: A
authors.initials: A
authors.lastname: Khan
authors.forename: M K
authors.initials: MK
authors.lastname: Schwartz
authors.forename: R W
authors.initials: RW
authors.lastname: Price
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid* / Q000150:complications / Q000473:pathology; D001812:Blood-Brain Barrier; D003704:Dementia / Q000150:complications; D006801:Humans; D009994:Osmolar Concentration; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid*
chemical_list: D001613:beta 2-Microglobulin