Potential involvement of renal transport mechanisms in nephrotoxicity.
Among the various physiological factors involved in the development of a nephrotoxic insult, certain renal transport systems may be important. The movement of exogenous organic anions and cations from the blood to the tubular fluid is well recognized. The anion transport system, which has been extensively characterized for the transport of p-aminohippuric acid, may have particular relevance. The nephrotoxic effect of citrinin, certain cephalosporin antibiotics and cysteine conjugates in rats and in isolated renal cells can be blocked by probenecid, a drug known to block the organic anion transporter competitively. The reduction in toxic response is correlated with the renal and cellular content of the nephrotoxic chemical.
Berndt
W O
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Department of Pharmacology, College of Medicine, University of Nebraska Medical Center, Omaha 68105.
D000818:Animals; D001692:Biological Transport; D064420:Drug-Related Side Effects and Adverse Reactions; D007674:Kidney Diseases / Q000139:chemically induced / Q000378:metabolism*; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism*; D051381:Rats