title: Levels of toxic shock syndrome toxin-1 production among Staphylococcus aureus strains and clinical implications.
abstract: Among 250 S. aureus clinical isolates, the incidence of TSST-1 production was 18.0%. S. aureus var. hominis strains were predominant (95.6%), producing high levels of toxin in vitro, within the range of 0.6 to 4.3 micrograms/ml and exhibiting crystal violet binding with C/D pattern. No correlation was found between the level of TSST-1 production in vitro and the clinical course. Two (3.4%) of the var. bovis strains produced toxin in amounts less than 0.6 micrograms/ml and did not bind crystal violet. None of the 24 var. canis isolates produced TSST-1. Fifty five per cent of the isolates of phage group I produced TSST-1 and corresponded to 57.8% of the toxigenic strains. Two of the 250 patients developed toxic shock syndrome.
authors.affiliation: Department of Medical Microbiology, University of Lund, Sweden.
authors.forename: A S
authors.initials: AS
authors.lastname: Naidu
authors.forename: C
authors.initials: C
authors.lastname: Kamme
authors.forename: A
authors.initials: A
authors.lastname: Ljungh
authors.forename: T
authors.initials: T
authors.lastname: Wadström
mesh_terms: D000293:Adolescent; D001427:Bacterial Toxins; D015373:Bacterial Typing Techniques; D001434:Bacteriophage Typing; D004768:Enterotoxins / Q000096:biosynthesis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005840:Gentian Violet; D006801:Humans; D008297:Male; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000145:classification / Q000378:metabolism*; D018089:Superantigens
chemical_list: D001427:Bacterial Toxins; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; D005840:Gentian Violet