[Antibacterial action of some saturated and unsaturated long-chain carboxylic acids and their bis(2-chloroethyl)aminoethyl esters in vitro].
Using the method of twofold serial dilution of substances in liquid nutrient medium with subsequent reseeding on solid nutrient medium a comparative study has been carried out of the antibacterial action in vitro of long chain saturated (C10-C18) and unsaturated (C11-C22) carboxylic acids and their bis(2-chloroethyl)aminoethyl esters against Pseudomonas aeruginosa, Klebsiella pneumoniae tp 16 Koph, Escherichia coli ATCC 25922, Staphylococcus aureus 101+ and Proteus mirabilis 56. The compounds studied have an inhibitory effect upon the development of the microorganisms. The minimum inhibitory concentration ranges from 1.8 to 19.3 mumol/ml. There exists a linear correlation between the length of the carbon chain (the number of C atoms) of the compounds and the minimum inhibitory concentration in the following cases: esters of saturated acids (C16-C24) and unsaturated acids (C11-C22) against Pseudomonas aeruginosa; unsaturated acids (C11-C22) against Klebsiella pneumoniae tp 16 Koph; esters of unsaturated acids (C17-C28) against Staphylococcus aureus 101+. This correlation has not been found in all other compounds against Escherichia coli ATCC 25922 and Proteus mirabilis 56.
Jossifova
L T
LT
Nationales Zentrum für Onkologie, Medizinische Akademie, Sofia.
Manolov
I
I
Golovinsky
E V
EV
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003470:Culture Media; D005227:Fatty Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009588:Nitrogen Mustard Compounds / Q000138:chemical synthesis / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D005227:Fatty Acids; D009588:Nitrogen Mustard Compounds
Antibakterielle Wirkung einiger gesättigter und ungesättigter langkettiger Carbonsäuren und deren Bis(2-chlorethyl)aminoethylester in vitro.