[Rapid chemiluminescence analysis of the effect of drugs on the functional activity of phagocytosing blood cells].
The effects of 46 drugs on luminol-dependent chemiluminescence of human whole blood leucocytes during phagocytosis were studied. Anti-inflammatory agents, antihistaminics and anticoagulants inhibited the chemiluminescent phagocytic response of leucocytes (CPRL) at concentrations comparable with therapeutic ones. LD50/ED50 (CPRL inhibition) factor of 3 is offered as the screening threshold for a number of nonsteroidal anti-inflammatory drugs. The possibility of using anticoagulants and anaprilin for the effect of resorption of myocardial infarction was postulated.
Kalmykov
S V
SV
Kazimirovskaia
V B
VB
Batunova
E V
EV
D006801:Humans; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology; D008163:Luminescent Measurements; D008165:Luminol / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects*; D012441:Saccharomyces cerevisiae; D013997:Time Factors
D008165:Luminol
Khemiliuminestsentnyĭ ékspress-analiz vliianiia lekarstvennykh veshchestv na funktsional'nuiu aktivnost' fagotsitiruiushchikh kletok krovi.