[Particulate contamination of infusion solutions and drug additives in the framework of long-term intensive therapy. 2. An animal model].
When IV solutions are used, particulate matter may be introduced into the patient. Using X-ray studies we could demonstrate particulate matter consisting mainly of glass from ampules, rubber from rubber stoppers of infusion bottles, and plastic material from IV sets. With a recently introduced method of back-scatter pictures in scanning electron microscopy combined with X-ray studies--Jeol 35 CF/EEDS II Ortec (REM EDX)--we analyzed this phenomenon using an animal model (rabbit). It appears that particulate matter is deposited in the interstitial lung tissue and especially the pulmonary microcirculation. Pathogenetic effects could also be demonstrated (formation of thrombi, etc.).
Walpot
H
H
Klinik für Anaesthesiologie, Medizinische Fakultät, Rheinisch-Westfälische Technische Hochschule Aachen.
Franke
R P
RP
Burchard
W G
WG
Agternkamp
C
C
Müller
F G
FG
Mittermayer
C
C
Kalff
G
G
D000818:Animals; D003422:Critical Care; D004340:Drug Contamination; D005260:Female; D005547:Foreign Bodies / Q000150:complications*; D007262:Infusions, Intravenous / Q000009:adverse effects*; D008171:Lung Diseases / Q000209:etiology / Q000473:pathology; D008297:Male; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D013997:Time Factors
Partikuläre Verunreinigung von Infusionslösungen und Medikamentenzusätzen im Rahmen einer Langzeit-Intensiv-Therapie. Teil 2. Tiermodell.