The efficacies of pure LICAM(C) and DTPA for enhancing the elimination of plutonium-238 and americium-241 from rats after their inhalation as nitrate.
After the inhalation of 238Pu and 241Am as nitrate, the repeated administration of DTPA is far superior to that of LICAM(C) for enhancing their elimination from the body. The therapeutic efficacies of these chelating agents are however similar after intravenous injection of 238Pu as citrate. It is concluded that DTPA should remain the agent of choice for treating persons contaminated internally with transportable forms of these actinides.
Stradling
G N
GN
National Radiological Protection Board, Didcot, Oxon, UK.
Stather
J W
JW
Gray
S A
SA
Moody
J C
JC
Ellender
M
M
Hodgson
A
A
D000280:Administration, Inhalation; D000576:Americium / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D002614:Chelating Agents / Q000494:pharmacology*; D005260:Female; D009566:Nitrates; D004369:Pentetic Acid / Q000494:pharmacology*; D011005:Plutonium / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D013095:Spermidine / Q000031:analogs & derivatives* / Q000494:pharmacology
D002614:Chelating Agents; D009566:Nitrates; C015459:plutonium nitrate; C041805:americium nitrate; D011005:Plutonium; C034834:LICAM-C; D004369:Pentetic Acid; D013095:Spermidine; D000576:Americium