Xeroderma pigmentosum.
Xeroderma pigmentosum is a rare, recessively inherited, sun-sensitive disorder with a defective DNA repair mechanism that is the best model currently available linking human cancer to exposure to a specific carcinogen. Laboratory and epidemiological studies of this disease are providing extensive insight into the etiology of cancer in the general population.
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D004260:DNA Repair / Q000528:radiation effects; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000235:genetics*; D013472:Sunlight / Q000009:adverse effects*; D014983:Xeroderma Pigmentosum / Q000235:genetics*