Trimethoprim resistance in enterobacteria isolated in Chile.
Four hundred strains of enterobacteria, isolated before the introduction of trimethoprim as a single agent in Chile, were studied. One hundred and thirty six strains (34%) were resistant to greater than or equal to 8 mg/l of trimethoprim and 118 of these (87%) were also resistant to sulphamethoxazole (156 mg/l). Plasmids were detected in 79% of the trimethoprim-resistant strains; 56% of the strains carried two or more plasmids. Trimethoprim resistance could be transferred by conjugation in 66% of the plasmid-carrying strains; this resistance was co-transferred with a variety of other antibiotic resistance determinants.
Urbina
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Departamento de Microbiología y Parasitología, Universidad de Chile, Santiago.
Prado
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Canelo
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D002677:Chile; D004269:DNA, Bacterial / Q000302:isolation & purification; D004755:Enterobacteriaceae / Q000187:drug effects*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects; D010957:Plasmids / Q000187:drug effects; D012016:Reference Values; D012760:Shigella / Q000187:drug effects; D013420:Sulfamethoxazole / Q000494:pharmacology / Q000627:therapeutic use; D014295:Trimethoprim / Q000494:pharmacology / Q000627:therapeutic use; D014296:Trimethoprim Resistance / Q000235:genetics*
D004269:DNA, Bacterial; D014295:Trimethoprim; D013420:Sulfamethoxazole