title: [Measurement of antibodies to human T-lymphotropic virus type-1 (HTLV-1) in cerebro-spinal fluid in patients infected HTLV-1 by blood transfusion].
abstract: Although determination of the presence of antibodies to HTLV-1 in cerebro-spinal fluid (CSF) is very important for the diagnosis of HTLV-1-associated myelopathy (HAM), these antibodies in CSF have not yet been completely investigated so far in patients without overt HAM. We examined antibodies to HTLV-1 in CSF of leukemia patients who were infected with this virus via blood transfusion. All of 5 patients showed positive antibody titer, one of 5 patients was a patient with overt HAM. According to Western-blotting analysis in CSF, IgG p-19, 24 and 28 antibodies were positive in 4 patients without overt HAM, but IgM antibody was negative. In contrast, IgG antibodies as well as IgM p-24 antibody were positive in patients with overt HAM. These results suggest that further studies on antibodies to HTLV-1, especially on IgM antibody, in CSF of HTLV-1 infected patients with or without overt HAM may be helpful to better understanding of the mechanism on onset of HAM following blood transfusion.
authors.affiliation: Department of Internal Medicine, Asahikawa Municipal Hospital, Hokkaido, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Maekawa
authors.forename: T
authors.initials: T
authors.lastname: Kawamura
authors.forename: T
authors.initials: T
authors.lastname: Miyake
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Kurosawa
mesh_terms: D000328:Adult; D005260:Female; D005455:Fluorescent Antibody Technique; D015481:HTLV-I Antibodies / Q000134:cerebrospinal fluid*; D015490:HTLV-I Infections / Q000175:diagnosis* / Q000635:transmission; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid*; D007938:Leukemia / Q000628:therapy; D008297:Male; D008875:Middle Aged; D065227:Transfusion Reaction
chemical_list: D015481:HTLV-I Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M