Genotoxicity of zinc in 4 short-term mutagenicity assays.
The genotoxicity of zinc was examined in 4 short-term mutagenicity assays. Zinc acetate produced dose-related positive responses in the L5178Y mouse lymphoma assay and an in vitro cytogenetic assay with Chinese hamster ovary cells, but was negative in the Salmonella mutation assay and did not induce unscheduled DNA synthesis in primary cultures of rat hepatocytes. Zinc-2,4-pentanedione produced frameshift mutations in Salmonella tester strains TA1538 and TA98, but did not induce unscheduled DNA synthesis in primary cultures of rat hepatocytes. The effect of ligand binding of zinc in the in vitro test systems is discussed.
Thompson
E D
ED
Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH 45239-8707.
McDermott
J A
JA
Zerkle
T B
TB
Skare
J A
JA
Evans
B L
BL
Cody
D B
DB
D000818:Animals; D002869:Chromosome Aberrations; D004260:DNA Repair / Q000187:drug effects; D066298:In Vitro Techniques; D051379:Mice; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects; D013997:Time Factors; D015032:Zinc / Q000633:toxicity*
D015032:Zinc