[Role of NK cells in lung metastasis immunosurveillance].
NK cells play an important role in fighting tumor metastases. The incidence of metastasis was found to increase in mice with low cytotoxicity of NK cells. In the mice with high cytotoxicity of NK cells, the incidence of metastasis decreased. LAK cells induced by IL2 mediate the regression of established metastases from a variety of tumors. LAK progenitor cells were predominantly found in CD3-CD16+ Leu19+ fraction, a subset that are known to be the NK cells. Thus, NK cell lineage in LAK cells plays an important role for the inhibition of tumor metastases. Cells having NK cell-like phenotype nature, however, also play a key role in the side effects of adoptive immunotherapy involving IL2. In order to decrease adverse side effects during therapy, we are currently testing combination therapy of LAK cells plus IL2, IL2 alone with IFN, TNF, BRM, indomethacin and so on. Overall, augmentation of NK cells is one of the significant therapeutic methods to prevent metastases.
Kobayashi
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Basic Medical Sciences Division, National Institute for Environmental Studies.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D007376:Interleukin-2 / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008175:Lung Neoplasms / Q000276:immunology / Q000556:secondary*; D051379:Mice; D015166:Monitoring, Immunologic
D007376:Interleukin-2