title: Adverse effects of fenfluramine in treatment refractory schizophrenia.
abstract: Fenfluramine was administered to eight severely ill schizophrenic patients as an adjunct to neuroleptic drugs in a double-blind, multiple baseline design. A significant adverse effect of fenfluramine on psychopathology was detected through nurses' ratings, target symptom scales, the Brief Psychiatric Rating Scale, and time-sampled behavioral observations. Clinical deterioration was correlated with fenfluramine-induced reductions in blood serotonin levels and persisted beyond the point of discontinuation of fenfluramine.
authors.affiliation: Department of Psychology, University of California, Los Angeles.
authors.forename: B D
authors.initials: BD
authors.lastname: Marshall
authors.forename: S M
authors.initials: SM
authors.lastname: Glynn
authors.forename: K K
authors.initials: KK
authors.lastname: Midha
authors.forename: J W
authors.initials: JW
authors.lastname: Hubbard
authors.forename: L L
authors.initials: LL
authors.lastname: Bowen
authors.forename: L
authors.initials: L
authors.lastname: Banzett
authors.forename: J
authors.initials: J
authors.lastname: Mintz
authors.forename: R P
authors.initials: RP
authors.lastname: Liberman
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005277:Fenfluramine / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011897:Random Allocation; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012701:Serotonin / Q000097:blood
chemical_list: D005277:Fenfluramine; D012701:Serotonin