The late results of renal transplantation and the importance of chronic rejection as a cause of graft loss.
The results of 279 renal transplants performed in a single centre between 1974 and 1986 are reviewed. Improvements in the management of acute rejection and a reduction in mortality have resulted in an improvement in 1-year actuarial graft survival rates from 44% for transplants performed before 1980 to 68% for those performed after 1983. After the second year post-transplant there has been a steady rate of graft failure (6% per annum), mainly due to chronic rejection. In total 52 grafts have developed chronic rejection (19% of the total and 30% of those at risk at 6 months). Chronic rejection is assuming greater relative importance as a cause of graft loss as early results improve.
Foster
M C
MC
Department of Surgery, City Hospital, Nottingham.
Wenham
P W
PW
Rowe
P A
PA
Burden
R P
RP
Morgan
A G
AG
Cotton
R E
RE
Blamey
R W
RW
D000328:Adult; D002908:Chronic Disease; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000401:mortality; D016030:Kidney Transplantation; D008297:Male; D013997:Time Factors
D007166:Immunosuppressive Agents