Novel histopathologic findings in a surviving case of hemolytic uremic syndrome after bone marrow transplantation.
We report novel renal histopathologic features in a patient with hemolytic uremic syndrome after allogeneic bone marrow transplantation who survived with plasma exchange therapy. This distribution of vascular lesions within the kidney differed from previously described cases, which were uniformly fatal, in that there were marked arterial changes in addition to arteriolar and glomerular microangiopathy. A high rate of frequency of apoptotic cells within glomeruli was found. These findings are discussed in terms of their pathogenetic and prognostic relevance.
Arends
M J
MJ
Department of Pathology, University Medical School, Edinburgh, UK.
Harrison
D J
DJ
D000293:Adolescent; D001485:Basement Membrane / Q000648:ultrastructure; D016026:Bone Marrow Transplantation; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology* / Q000648:ultrastructure; D007678:Kidney Glomerulus / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D011183:Postoperative Complications