title: Drug resistance in cancer: an overview of the clinical aspects.
abstract: The primary cause of failure of the pharmacological treatment of cancer is the occurrence of intrinsic or acquired resistance to drugs in tumor cells. Drug resistance occurs through a variety of mechanisms and usually results from mutation or amplification of genes. Biochemical and genetic mechanisms by which tumor cells may become resistant clinically to chemotherapeutic agents are reviewed. Strategies for preventing or circumventing drug resistance are also discussed.
authors.affiliation: Dip. di Farmacologia, Firenze, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Periti
authors.forename: E
authors.initials: E
authors.lastname: Mini
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents