Estimation of quantal dose response of drugs by the Spearman-Karber method: a computer program written in BASIC.
Quantal-dose response is an important concept in pharmacology and toxicology. The best known variables are the median effective dose and the median lethal dose. These are measured according to the frequency of dichotomous response of the subjects being studied. The Spearman-Karber method is a simple and convenient algorithm to evaluate these indices. A highly portable computer program in BASIC language is also included for the convenience of computation.
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D000465:Algorithms; D004305:Dose-Response Relationship, Drug; D007928:Lethal Dose 50; D012984:Software