title: Synthesis and biological activity of a cyclic hexapeptide related to peptide T.
abstract: The cyclo [Thr-Thr-Thr-Tyr-Asn-Thr] hexapeptide related to peptide T, H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH, competitor of the Human Immunodeficiency Virus in the binding to human T cells, was synthesized and tested for its ability to stimulate monocyte migration (chemotaxis). The new cyclic derivative showed negligible biological activity.
authors.affiliation: Dipartimento Scienze Farmaceutiche, Università di Ferrara, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Bianchi
authors.forename: V
authors.initials: V
authors.lastname: Scaranari
authors.forename: R
authors.initials: R
authors.lastname: Tomatis
mesh_terms: D000595:Amino Acid Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D009000:Monocytes / Q000187:drug effects; D015717:Peptide T / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D015717:Peptide T