title: The effect of a cetylpyridinium chloride (CPC) detergent foam compared to a conventional toothpaste on plaque and gingivitis. A single blind crossover study.
abstract: A CPC-detergent formulation in a foam vehicle, was compared with a fluoride toothpaste for its ability to prevent plaque and gingivitis over a period of 12 days. Whilst refraining from all other oral hygiene procedures, the foam or toothpaste was applied to the teeth in fluoride application trays, in a group of 14 volunteers. At days 8 and 12 of this crossover study, the following assessments were made: gingival crevicular fluid; gingival index; bleeding on probing; plaque index; plaque area. Except for plaque area at day 8 of the study, there were no significant differences between the 2 products at either day 8 or day 12. It is therefore concluded that the CPC-detergent formulation, in its present form, does not inhibit plaque and gingivitis more effectively than a conventional fluoride toothpaste.
authors.affiliation: Department of Periodontology, University of Wales College of Medicine, Cardiff, UK.
authors.forename: M
authors.initials: M
authors.lastname: Addy
authors.forename: J
authors.initials: J
authors.lastname: Moran
mesh_terms: D000293:Adolescent; D000328:Adult; D002594:Cetylpyridinium / Q000627:therapeutic use*; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D003802:Dentifrices; D005260:Female; D005459:Fluorides / Q000627:therapeutic use*; D005883:Gingival Crevicular Fluid; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D010512:Periodontal Index; D010592:Pharmaceutic Aids; D010710:Phosphates / Q000627:therapeutic use; D011726:Pyridinium Compounds / Q000627:therapeutic use*; D012969:Sodium Fluoride / Q000627:therapeutic use; D014100:Toothpastes
chemical_list: D003802:Dentifrices; D010592:Pharmaceutic Aids; D010710:Phosphates; D011726:Pyridinium Compounds; D014100:Toothpastes; C012980:fluorophosphate; D012969:Sodium Fluoride; D002594:Cetylpyridinium; D005459:Fluorides