title: Test of effect of lipid lowering by diet on cardiovascular risk. The Minnesota Coronary Survey.
abstract: The Minnesota Coronary Survey was a 4.5-year, open enrollment, single end-time double-blind, randomized clinical trial that was conducted in six Minnesota state mental hospitals and one nursing home. It involved 4393 institutionalized men and 4664 institutionalized women. The trial compared the effects of a 39% fat control diet (18% saturated fat, 5% polyunsaturated fat, 16% monounsaturated fat, 446 mg dietary cholesterol per day) with a 38% fat treatment diet (9% saturated fat, 15% polyunsaturated fat, 14% monounsaturated fat, 166 mg dietary cholesterol per day) on serum cholesterol levels and the incidence of myocardial infarctions, sudden deaths, and all-cause mortality. The mean duration of time on the diets was 384 days, with 1568 subjects consuming the diet for over 2 years. The mean serum cholesterol level in the pre-admission period was 207 mg/dl, falling to 175 mg/dl in the treatment group and 203 mg/dl in the control group. For the entire study population, no differences between the treatment and control groups were observed for cardiovascular events, cardiovascular deaths, or total mortality. A favorable trend for all these end-points occurred in some younger age groups.
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis 55455.
authors.forename: I D
authors.initials: ID
authors.lastname: Frantz
authors.forename: E A
authors.initials: EA
authors.lastname: Dawson
authors.forename: P L
authors.initials: PL
authors.lastname: Ashman
authors.forename: L C
authors.initials: LC
authors.lastname: Gatewood
authors.forename: G E
authors.initials: GE
authors.lastname: Bartsch
authors.forename: K
authors.initials: K
authors.lastname: Kuba
authors.forename: E R
authors.initials: ER
authors.lastname: Brewer
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D004041:Dietary Fats / Q000008:administration & dosage*; D004311:Double-Blind Method; D005224:Fats, Unsaturated / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D002791:Cholesterol, Dietary; D004041:Dietary Fats; D005224:Fats, Unsaturated; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol