[Effect of intravenous infusion of nimodipine on intracranial pressure. Experimental study of ICP measurement conducted in a rat model].
The effect of the intravenous, continuous nimodipine infusion on ICP in a rat was studied. 5 to 8 minutes after the beginning of infusion ICP started to increase, and at 30 minutes was 35-70% higher than initially, subsequently stabilizing at this level. After finishing the infusion, ICP returned to normal values within 30-45 minutes. The authors discuss possible clinical implications of ICP increase produced by nimodipine.
Kotwica
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Katedry Neurochirurgii AM w Lodzi.
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D000818:Animals; D015170:Cerebrospinal Fluid Pressure / Q000187:drug effects* / Q000502:physiology; D007262:Infusions, Intravenous; D007427:Intracranial Pressure / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008959:Models, Neurological; D009553:Nimodipine / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D009553:Nimodipine
Wpływ dozylnego wlewu nimodipiny na ciśnienie wewnatrzczaszkowe. Praca doświadczalna na modelu pomiaru ICP u szczura.