Naturally occurring anti-band 3 autoantibodies recognize a high molecular weight protein on the surface of Plasmodium falciparum infected erythrocytes.
Naturally occurring anti-band 3 autoantibodies bind to erythrocytes infected with a knobby variant of the human malaria Plasmodium falciparum (FCR-3 strain). The autoantibodies recognized a greater than 240 kDa protein in SDS extracts made from surface iodinated infected erythrocytes. The antigen was associated only with erythrocytes infected with a knobby variant, and was removed by trypsin treatment of intact infected cells. By two-dimensional peptide map analysis the antigen was shown to be structurally related to the human erythrocyte anion transporter, band 3.
Winograd
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Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138.
Sherman
I W
IW
D000818:Animals; D001457:Anion Exchange Protein 1, Erythrocyte / Q000276:immunology*; D000954:Antigens, Surface / Q000032:analysis*; D001323:Autoantibodies / Q000276:immunology*; D001345:Autoradiography; D001798:Blood Proteins / Q000032:analysis* / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D004912:Erythrocytes / Q000032:analysis / Q000276:immunology / Q000469:parasitology*; D006801:Humans; D007163:Immunosorbent Techniques; D008970:Molecular Weight; D010963:Plasmodium falciparum
D001457:Anion Exchange Protein 1, Erythrocyte; D000954:Antigens, Surface; D001323:Autoantibodies; D001798:Blood Proteins