title: Evaluation of the ability of altrenogest to control the equine estrous cycle.
abstract: In our experience, altrenogest has not always been able to exert predictable control over the estrous cycle of the mare. Therefore, we examined 12 mares that were treated with altrenogest to identify reasons for its failure to control the estrous cycle. The mares were fed altrenogest for 15 to 20 days and were examined for follicle development, ovulation, and corpus luteum formation during treatment. Through the use of real-time ultrasonography and radioimmunoassay for progesterone, we concluded that altrenogest was unable to suppress the growth of follicles to preovulatory size in some mares, leading to ovulation during treatment or earlier than expected after the end of treatment. In addition, altrenogest did not appear to shorten the life-spans of the corpora lutea that were formed during treatment; in 4 mares, this resulted in the persistence of corpora lutea after the end of the suggested 15-day periods of treatment. The latter findings led us to suggest that if a luteolytic dose of prostaglandin had been given at the end of altrenogest treatment, there would have been improved control over the estrous cycle. The results of our study confirmed our clinical impressions that altrenogest may be satisfactory to control the equine estrous cycle under some circumstances, but it should not be used when precise control over ovulation is required.
authors.affiliation: Department of Medicine, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.
authors.forename: R M
authors.initials: RM
authors.lastname: Lofstedt
authors.forename: J H
authors.initials: JH
authors.lastname: Patel
mesh_terms: D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects / Q000502:physiology; D004963:Estrenes / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D006736:Horses / Q000502:physiology*; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology; D010060:Ovulation / Q000187:drug effects; D011374:Progesterone / Q000097:blood; D045167:Progesterone Congeners / Q000494:pharmacology*; D011863:Radioimmunoassay; D014204:Trenbolone Acetate / Q000031:analogs & derivatives / Q000494:pharmacology*; D014463:Ultrasonography / Q000662:veterinary
chemical_list: D004963:Estrenes; D045167:Progesterone Congeners; C023445:altrenogest; D011374:Progesterone; D014204:Trenbolone Acetate