Augmentation of donor-specific transfusion and cyclosporine effects with dietary linoleic acid.
Increased prostaglandin production is a possible mechanism for the immunosuppressive effects of both cyclosporine and blood transfusions. Therefore, dietary supplementation with linoleic acid, a prostaglandin precursor, combined with either modality could act synergistically. Intraabdominal cardiac allografts were performed from Buffalo rat donors to Lewis recipients. Transplant recipients received a single donor-specific transfusion, low-dose cyclosporine (CsA, 1 mg/kd/d x 7 days), dietary supplementation with linoleic acid (LA, 16% of total calories) or a combination of the three modalities. CsA, DST or LA alone significantly prolonged allograft survival. Both CsA and LA acted synergistically with DST in further prolongation of survival--however, animals receiving all three modalities achieved 100% long-term survival. Augmentation of transfusion- and cyclosporine-induced immunosuppression with dietary prostaglandin precursor is possible.
Perez
R V
RV
Department of Surgery, University of Cincinnati, Ohio 45267-0558.
Munda
R
R
Alexander
J W
JW
D000818:Animals; D001803:Blood Transfusion; D003131:Combined Modality Therapy; D003524:Cyclosporins / Q000627:therapeutic use*; D004041:Dietary Fats / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006082:Graft Enhancement, Immunologic / Q000379:methods; D006085:Graft Survival / Q000187:drug effects; D016027:Heart Transplantation; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011915:Rats, Inbred BUF; D011917:Rats, Inbred Lew; D014019:Tissue Donors
D003524:Cyclosporins; D004041:Dietary Fats; D008041:Linoleic Acids; D019787:Linoleic Acid