[Effect of amines on insulin-stimulated processes: the transport of sugars and synthesis of glycogen in frog sartorius muscles].
Amines and amides were found to inhibit the process of stimulation of sugar transport in muscle tissue (N. A. Vinogradova et al., 1978). The present paper reports results of experiments on frog sartorius muscles acted upon by amines and other substances that inhibit induction of cultured cell proliferation. The stimulation of sugar transport induced by insulin, 2,4-dinitrophenol, or KCl was found to be inhibited by dansylcadaverine (1 mM), 5-methoxytryptamine (2 mM), or methylamine (100 mM). Such substances as chloroquine, bacitracin, or monensin exerted no effect. Besides, dansylcadaverine (1 mM), and 5-methoxytryptamine inhibited the stimulation of insulin induced glycogen synthesis. Dansylcadaverine was ineffective at concentrations lower than 0.5 mM. It is suggested that the inhibitory action of amines depends on their influence on the processes of membrane protein phosphorylation.
Vinogradova
N A
NA
Kudriavtseva
N V
NV
Nikol'skiĭ
N N
NN
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D050260:Carbohydrate Metabolism; D004347:Drug Interactions; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000096:biosynthesis*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D011896:Rana temporaria
D000588:Amines; D007328:Insulin; D006003:Glycogen; D005947:Glucose
Vliianie aminov na insulinstimuliruemye protsessy: transport sakharov i sintez glikogena v portniazhnykh myshtsakh liagushki.