title: Ultraviolet mutagenesis and the SOS response in Escherichia coli: a personal perspective.
abstract: The study of ultraviolet (UV) mutagenesis in Escherichia coli began with the assumption that genes were likely to be changed at the instant of photon absorption. Over many decades, it became clear that postirradiation cellular activities, including enzymatic DNA repair of UV photo products and error-prone modes of tolerating unrepaired DNA lesions can exert profound influences on the mutagenic outcome of irradiation. Current study focusses on the molecular details of radiation-induced translesion DNA replication as the final event in UV mutagenesis.
authors.affiliation: Waksman Institute of Microbiology, Rutgers, State University of New Jersey, Piscataway 08854.
authors.forename: E M
authors.initials: EM
authors.lastname: Witkin
mesh_terms: D004260:DNA Repair; D004926:Escherichia coli / Q000528:radiation effects*; D049673:History, 20th Century; D009152:Mutagenicity Tests / Q000266:history*; D009153:Mutagens; D009154:Mutation; D013014:SOS Response, Genetics; D014466:Ultraviolet Rays; D014481:United States
chemical_list: D009153:Mutagens