Evolution of social concerns and environmental policies for chemical mutagens.
The founding of the Environmental Mutagen Society 20 years ago coincided with the beginning of general social concern about exposure to chemical mutagens. Initially, this concern focused on the potential of chemicals to induce heritable genetic damage in humans. Within a few years, however, mutagenicity tests came to be regarded primarily as short-term tests for carcinogenicity. Serious doubts have recently been cast upon the relationship between mutagenicity and carcinogenicity, and, as a result the real utility of mutagenicity tests is being questioned. Justification for the continued use of these tests will require 1) more detailed mechanistic knowledge concerning the role of genetic changes in the development of cancer and 2) an improved ability to relate the results of mutagenicity tests to the potential for inducing heritable genetic effects in humans.
Prival
M J
MJ
Genetic Toxicology Branch, U.S. Food and Drug Administration, Washington, DC 20204.
Dellarco
V L
VL
D002274:Carcinogens, Environmental; D005826:Genetics, Medical / Q000266:history; D049673:History, 20th Century; D006801:Humans; D009152:Mutagenicity Tests / Q000266:history*; D009153:Mutagens; D011640:Public Policy; D011788:Quality of Life; D014481:United States
D002274:Carcinogens, Environmental; D009153:Mutagens