Cholinergic hypothesis of depression: a reappraisal.
Evidence for the cholinergic hypothesis of depression is reviewed, arguments directed against this hypothesis are set forth, and the strengths and weaknesses of these criticisms are discussed. The authors conclude that the cholinergic hypothesis is tenable but suggest new areas of study.
Dilsaver
S C
SC
Department of Psychiatry and Neuroscience, Ohio State University, Columbus 43210.
Coffman
J A
JA
D000109:Acetylcholine / Q000502:physiology; D001143:Arousal / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D003866:Depressive Disorder / Q000503:physiopathology*; D006801:Humans; D011950:Receptors, Cholinergic / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000502:physiology; D011978:Receptors, Nicotinic / Q000502:physiology
D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D000109:Acetylcholine