title: Chromosome error propagation and cancer.
abstract: A general characteristic of tumour cells is their unstable karyotype. It is suggested here that maintenance of the normal diploid cell depends on the presence of two copies of specific genes; a change in gene dosage of one or more of these genes, by chromosome nondisjunction or rearrangement, may trigger a general loss of accuracy in chromosome segregation at mitosis.
authors.forename: R
authors.initials: R
authors.lastname: Holliday
mesh_terms: D002869:Chromosome Aberrations; D015321:Gene Rearrangement; D009369:Neoplasms / Q000235:genetics*; D009630:Nondisjunction, Genetic; D011003:Ploidies