Management of prolactinomas.
Prolactinomas are the most common of the hormone-secreting pituitary tumors and must be distinguished from nonsecreting tumors causing hyperprolactinemia by hypothalamic or stalk dysfunction. For both micro- and macroadenomas, dopamine agonists appear to be the treatment of choice, transsphenoidal surgery being reserved for nonresponders. For women desiring pregnancy, dopamine agonists are safe when there is a microadenoma or an intrasellar macroadenoma. However, in women with large macroadenomas desiring pregnancy, limited transsphenoidal decompression followed by bromocriptine appears to be the safest mode of treatment.
Molitch
M E
ME
Center for Endocrinology, Metabolism, and Nutrition, Northwestern University Medical School, Chicago, Illinois 60611.
D005260:Female; D006801:Humans; D010911:Pituitary Neoplasms / Q000628:therapy*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000628:therapy; D015175:Prolactinoma / Q000628:therapy*