[Changes in the deformability of erythrocytes and 2,3-DPG in coronary artery stenosis].
The changes of deformability of RBC and 2,3-DPG in RBC in patients with coronary artery stenosis and the influence of some factors on them were studied. The results showed that: (1) the deformability index was inversely proportional to the degree of lesions of coronary vessels (P less than 0.01); (2) the 2,3-DPG was inversely proportional to the degree of lesions of coronary vessels (P less than 0.01); (3) there was a significant decrease in deformability index after using contrast medium; (4) Saliva may increase deformability of RBC and 2,3-DPG; (5) Nifedipine may increase deformability of RBC. These results showed: (1) the possible existence of microcirculatory dysfunction in coronary artery disease and in parallel of impaired deformability of RBC; (2) the possibility of normalization of the decreased deformability of 2,3-DPG in RBC by Salvia; (3) the possibility of increase of velocity of blood flow in microcirculation in coronary artery disease by Salvia.
Jiang
S S
SS
Yu
G R
GR
Zhang
S H
SH
D019794:2,3-Diphosphoglycerate; D003327:Coronary Disease / Q000097:blood*; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004338:Drug Combinations / Q000494:pharmacology; D004365:Drugs, Chinese Herbal; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology; D010618:Phenanthrolines / Q000494:pharmacology; D010936:Plant Extracts; D027561:Salvia miltiorrhiza
D004163:Diphosphoglyceric Acids; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010618:Phenanthrolines; D010936:Plant Extracts; D019794:2,3-Diphosphoglycerate; C028972:dan-shen root extract; D009543:Nifedipine