title: Interleukin-1 and lipid metabolism in the rat.
abstract: Intravenous administration of a single dose (20 micrograms) of recombinant interleukin-1-beta to virgin, lactating and litter-removed rats rapidly decreased intestinal lipid absorption in all groups. In vivo, oxidation of [14C]triolein to 14CO2 was also significantly decreased by interleukin-1. In addition, the cytokine decreased [14C]lipid accumulation in the mammary gland of lactating rats and in the adipose tissue of virgin and litter-removed rats. The decrease in lipid uptake in the interleukin-treated rats was accompanied by hypertriglyceridaemia; however, there was no significant decrease in tissue lipoprotein lipase activity, except in heart from lactating rats. In contrast, interleukin-1 administration had no effect on lipogenesis in liver, white or brown adipose tissue of virgin rats fed on glucose. These results suggest that interleukin-1 profoundly affects lipid metabolism by delaying intestinal absorption and decreasing tissue uptake.
authors.affiliation: Metabolic Research Laboratory, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, U.K.
authors.forename: J M
authors.initials: JM
authors.lastname: Argilés
authors.forename: F J
authors.initials: FJ
authors.lastname: Lopez-Soriano
authors.forename: R D
authors.initials: RD
authors.lastname: Evans
authors.forename: D H
authors.initials: DH
authors.lastname: Williamson
mesh_terms: D000818:Animals; D005260:Female; D007328:Insulin / Q000097:blood; D007375:Interleukin-1 / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects; D007774:Lactation / Q000378:metabolism; D050356:Lipid Metabolism; D008071:Lipoprotein Lipase / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood; D014304:Triolein / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D007328:Insulin; D007375:Interleukin-1; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D014304:Triolein; D008071:Lipoprotein Lipase