Comparison of various treatment modes in terms of beta 2-microglobulin removal: hemodialysis, hemofiltration, and push/pull HDF.
The beta 2-microglobulin clearance increased as the convective transport was added during hemodialysis to perform hemodiafiltration (HDF), suggesting that a convective transport type artificial kidney is more effective for beta 2-microglobulin removal. Actually, the decrease in the plasma beta 2-microglobulin level per treatment was more pronounced in hemofiltration and push/pull HDF than in hemodialysis. In the present study, no significant fluctuation in the pretreatment level of beta 2-microglobulin was shown by serial treatment by hemodialysis, whereas an obvious decreasing trend of it was indicated in serial treatment of either push/pull HDF or hemofiltration. Moreover, our study indicated that the ratio of posttreatment beta 2-microglobulin level in relation to its pretreatment level increases as the treatment by hemofiltration or push/pull HDF is repeated.
Shinzato
T
T
Department of Internal Medicine, Nagoya University Branch Hospital, Japan.
Kobayakawa
H
H
Maeda
K
K
D000682:Amyloid; D005260:Female; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D007688:Kidneys, Artificial; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*; D001613:beta 2-Microglobulin
D000682:Amyloid; D001613:beta 2-Microglobulin