title: Neonatal septicaemia in Finland 1981-85. Predominance of group B streptococcal infections with very early onset.
abstract: A survey of blood culture-confirmed neonatal septicaemia was carried out in seven delivery hospitals in 1981-85, for a second successive five-year period. The total number of cases was 377, to compare with 410 in the previous five-year period. Group B streptococcus (GBS) was throughout the major pathogen (29%), followed by Staphylococcus aureus (15%) and Escherichia coli (14%), while Staphylococcus epidermidis (10%) has emerged as a significant new causative agent. Septicaemia with very early onset was predominant: 49% of the cases had onset within the first 24 hours; in the majority the symptoms were present from birth. GBS was responsible for 49% of the cases detected in the first 24 hours of life. The overall mortality was 20% as compared to 23% in the previous five-year period, whereas in the very early onset septicaemia mortality was now 18%, down from the preceding 30%. Despite the modest progress, GBS septicaemia with very early onset remains a significant problem, and effective preventive measures are needed.
authors.affiliation: Department of Clinical Sciences, University of Tampere, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Vesikari
authors.forename: E
authors.initials: E
authors.lastname: Isolauri
authors.forename: N
authors.initials: N
authors.lastname: Tuppurainen
authors.forename: M
authors.initials: M
authors.lastname: Renlund
authors.forename: M
authors.initials: M
authors.lastname: Koivisto
authors.forename: M
authors.initials: M
authors.lastname: Janas
authors.forename: R S
authors.initials: RS
authors.lastname: Ikonen
authors.forename: P
authors.initials: P
authors.lastname: Kero
authors.forename: K
authors.initials: K
authors.lastname: Heinonen
authors.forename: R
authors.initials: R
authors.lastname: Nyman
mesh_terms: D005387:Finland; D006801:Humans; D007231:Infant, Newborn; D011379:Prognosis; D018805:Sepsis / Q000453:epidemiology* / Q000382:microbiology; D013290:Streptococcal Infections / Q000453:epidemiology*; D013292:Streptococcus agalactiae / Q000302:isolation & purification