title: [Research on the molecular basis of neoplasms: malignant melanoma as an example].
abstract: Knowledge about genetic alterations occurring in human tumors has dramatically increased following the development of cytogenetic and molecular techniques. Various alterations have been characterized: chromosomal damages, oncogene activations, loss of genetic material. Some of those alterations, such as c-abl rearrangements in certain leukemias, are characteristic of a certain type of malignancy. However, in most tumors, no such correlation has been demonstrated. We review here the genetic alterations discovered in human malignant melanomas.
authors.affiliation: Unité 119 INSERM, Marseille, France.
authors.forename: D
authors.initials: D
authors.lastname: Birnbaum
authors.forename: J
authors.initials: J
authors.lastname: Adelaide
authors.forename: I
authors.initials: I
authors.lastname: Marics
authors.forename: F
authors.initials: F
authors.lastname: Raybaud
mesh_terms: D002471:Cell Transformation, Neoplastic; D004273:DNA, Neoplasm / Q000235:genetics; D011905:Genes, ras; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D009857:Oncogenes; D014162:Transfection; D014170:Transformation, Genetic
chemical_list: D004273:DNA, Neoplasm
vernacular_title: Recherche d'une base moléculaire des cancers: l'exemple des mélanomemalins.