Fatal hepatitis B reactivation after autologous bone marrow transplantation.
We report a fatal case of hepatitis B reactivation following autologous bone marrow transplantation for acute lymphocytic leukaemia. The presence of antibodies to HBs and HBc at presentation indicated previous infection with hepatitis B; these antibodies disappeared during the course of treatment for leukaemia. HBsAg was first detected in serum 5 weeks post-transplant; liver function tests began to deteriorate 8 weeks later, when HBeAg was first detected. The hepatitis followed a fulminant course, and the patient died 10 days later, in the 15th week following transplant.
Webster
A
A
Department of Virology, Royal Free Hospital, London, UK.
Brenner
M K
MK
Prentice
H G
HG
Griffiths
P D
PD
D000293:Adolescent; D016026:Bone Marrow Transplantation; D002353:Carrier State / Q000209:etiology / Q000401:mortality; D005260:Female; D006509:Hepatitis B / Q000209:etiology* / Q000401:mortality; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000601:surgery; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality; D014182:Transplantation, Autologous / Q000401:mortality; D014775:Virus Activation