title: Adult-onset cyclic bicytopenia: a case report and review of treatment of cyclic hematopoiesis.
abstract: A unique case of adult-onset synchronous cyclic neutropenia and thrombocytopenia occurring at six-week intervals is presented. Periods of cytopenia were associated with fever, myalgias, gastrointestinal symptoms, and mild mucocutaneous bleeding. Alternate-day steroid treatment failed to correct the periodic fluctuations in peripheral blood counts but ameliorated symptoms during cytopenia. The treatment of cyclic hematopoiesis is reviewed.
authors.affiliation: Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55905.
authors.forename: A
authors.initials: A
authors.lastname: Tefferi
authors.forename: L A
authors.initials: LA
authors.lastname: Solberg
authors.forename: R M
authors.initials: RM
authors.lastname: Petitt
authors.forename: L G
authors.initials: LG
authors.lastname: Willis
mesh_terms: D000380:Agranulocytosis / Q000150:complications*; D001772:Blood Cell Count; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000145:classification; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D010507:Periodicity; D011241:Prednisone / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000097:blood / Q000150:complications* / Q000188:drug therapy
chemical_list: D011241:Prednisone