A role for biotin in bone growth.
Biotin deficiency in chicks changed the leg-bone modeling pattern. The mid-diaphyseal cortex was thickest medially instead of laterally as in normal chicks. Furthermore, periosteal bone appositional and bone formation rates were reduced in tibiotarsi of biotin-deficient chicks.
D000818:Animals; D001710:Biotin / Q000502:physiology*; D001846:Bone Development; D002645:Chickens; D008297:Male
D001710:Biotin