Hypoxic neuropathy: does hypoxia play a role in diabetic neuropathy? The 1988 Robert Wartenberg lecture.
In this report I review: (1) the blood supply and endoneurial microenvironment of nerve; (2) the class, type, and spatial distribution of nerve fiber degeneration as a function of number, site, and class of vessels occluded; (3) the putative mechanisms of nerve hypoxia; and (4) the role of hypoxia in diabetic polyneuropathy.
Dyck
P J
PJ
Peripheral Neuropathy Research Laboratory, Mayo Clinic, Rochester, MN 55905.
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000473:pathology; D001696:Biomechanical Phenomena; D003929:Diabetic Neuropathies / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D007511:Ischemia / Q000473:pathology; D008959:Models, Neurological; D009410:Nerve Degeneration; D009412:Nerve Fibers / Q000473:pathology; D010525:Peripheral Nerves / Q000033:anatomy & histology / Q000098:blood supply