SAR-2: identification of a novel plasmid-encoded beta-lactamase from India.
A novel beta-lactamase has been identified in an Escherichia coli strain isolated in South India. The beta-lactamase gene was carried on a plasmid (pUK734) along with resistance determinants to sulphonamides and tetracycline. The novel enzyme has a pI of 8.3 and an Mr of 36,000. The enzyme has a broad-spectrum of activity against both penicillins and cephalosporins. It is also active against oxacillin and methicillin.
Nandivada
L S
LS
Department of Bacteriology, Medical School, University of Edinburgh, U.K.
Amyes
S G
SG
D003227:Conjugation, Genetic; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007194:India; D007526:Isoelectric Point; D008970:Molecular Weight; D011815:R Factors; D013379:Substrate Specificity; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000235:genetics* / Q000302:isolation & purification
D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases