title: Pitfalls in assessing efficacy and side-effects of antidepressants.
abstract: Pitfalls in designing studies to test efficacy of new antidepressants occur in a number of different areas, including the criteria used for selecting patients, the choice of rating instruments for the assessment of severity, the length of treatment and the size of the study. Similarly there are pitfalls in the assessment of the side-effects of a compound. The paper considers each of these pitfalls and also the assessment of risk of adverse drug reactions.
authors.affiliation: Academic Department of Psychiatry, St Mary's Hospital, London, England.
authors.forename: S A
authors.initials: SA
authors.lastname: Montgomery
authors.forename: M T
authors.initials: MT
authors.lastname: Lambert
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D011569:Psychiatric Status Rating Scales
chemical_list: D000928:Antidepressive Agents