title: Induction of bronchial hyperresponsiveness by Bordetella bronchiseptica infection in dogs.
abstract: Six beagles were examined for time-related changes of bronchial responsiveness to methacholine, plasma histamine and thromboxane B2, and biopsy of bronchial tissues after intratracheal injection of Bordetella bronchiseptica. A progressive increase in bronchial responsiveness was induced after injection. The mediators, however, did not elevate and tissue neutrophil counts did not correlate with increased airway hyperresponsiveness. Intratracheal injection of heat-killed Bordetella bronchiseptica produced no alteration in these parameters. Thus, it is speculated that airway epithelial damage and effects on ciliostatic function induced by the organism are primarily involved in the pathogenesis.
authors.affiliation: Showa University, School of Medicine, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nishikata
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
authors.forename: M
authors.initials: M
authors.lastname: Adachi
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Soejima
authors.forename: K
authors.initials: K
authors.lastname: Hosono
authors.forename: M
authors.initials: M
authors.lastname: Toda
mesh_terms: D000818:Animals; D001706:Biopsy; D001885:Bordetella Infections / Q000150:complications*; D001980:Bronchi / Q000473:pathology / Q000503:physiopathology; D001982:Bronchial Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D004285:Dogs; D005260:Female; D006632:Histamine / Q000097:blood; D007958:Leukocyte Count; D016210:Methacholine Chloride; D008688:Methacholine Compounds; D009504:Neutrophils / Q000473:pathology; D012130:Respiratory Hypersensitivity / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D013929:Thromboxane B2 / Q000097:blood
chemical_list: D008688:Methacholine Compounds; D016210:Methacholine Chloride; D013929:Thromboxane B2; D006632:Histamine