title: Antibiotic prophylaxis in acute nonperforated appendicitis. The Danish Multicenter Study Group III.
abstract: In a prospective, block-randomized, multicenter study, the safety and efficacy of cefoxitin in preoperative prophylaxis were studied. 1735 patients undergoing appendectomy were evaluable, and half of these patients received 2 g of cefoxitin before undergoing operation. The patients were divided into three groups: patients with a normal appendix, patients with an acutely inflamed appendix, and patients with a gangrenous appendix. The study showed for each group a significant reduction of the incidence of wound infection in patients receiving prophylaxis. However, intra-abdominal abscess formation was not influenced by preoperative antibiotic prophylaxis. Consequently, routine preoperative prophylaxis is recommended before appendectomy.
authors.affiliation: Department of Surgery, General Hospital of Roenne, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Bauer
authors.forename: B
authors.initials: B
authors.lastname: Vennits
authors.forename: B
authors.initials: B
authors.lastname: Holm
authors.forename: J
authors.initials: J
authors.lastname: Hahn-Pedersen
authors.forename: D
authors.initials: D
authors.lastname: Lysen
authors.forename: H
authors.initials: H
authors.lastname: Galatius
authors.forename: E S
authors.initials: ES
authors.lastname: Kristensen
authors.forename: P
authors.initials: P
authors.lastname: Graversen
authors.forename: F
authors.initials: F
authors.lastname: Wilhelmsen
authors.forename: H
authors.initials: H
authors.lastname: Skjoldborg
mesh_terms: D000005:Abdomen; D000038:Abscess / Q000517:prevention & control; D000208:Acute Disease; D000328:Adult; D001062:Appendectomy; D001064:Appendicitis / Q000601:surgery*; D002440:Cefoxitin / Q000627:therapeutic use*; D003718:Denmark; D005260:Female; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D002440:Cefoxitin