'Nuclear' oncogenes convert extracellular stimuli into changes in the genetic program.
Recent discoveries have advanced our understanding of oncogene action: transcription factors are encoded by cellular (nuclear) oncogenes and the activity of transcription factors is modulated in response to extracellular stimuli. Moreover, the nuclear oncoproteins appear to represent the gene-proximal ends of a network of cellular oncoproteins that link extracellular stimuli to the transcriptional machinery and thus to the program of genes a cell will express.
Herrlich
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Ponta
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D005786:Gene Expression Regulation; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology; D009857:Oncogenes; D010641:Phenotype; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D009687:Nuclear Proteins; D014157:Transcription Factors