[Pharmacokinetics of salicylate in rabbits with acute renal damage].
Changes in the pharmacokinetics and metabolism of sodium salicylate were studied in rabbits with acute renal damage induced by intravenous administration of uranyl nitrate in the dose of 0.2 mg/kg. In the pathological group there occurs a marked decrease in elimination characteristics, the total plasma clearance of salicylate linearly decreasing with a decrease in the value of glomerular filtration rate. The plasma levels of creatinine and urea are suitable indices for the estimation of the changes in the plasma binding of salicylate. An increase in the fraction of free salicylate in the plasma of rabbits with acute impairment of the kidney results in a not very conclusive increase in the size of distributional volumes. In the control group mainly the unchanged drug is excreted into urine, whereas in rabbits with acute renal damage salicylate metabolites represent the majority of the eliminated amount.
Láznícek
M
M
Melicharová
L
L
Láznícková
A
A
Kvĕtina
J
J
D058186:Acute Kidney Injury / Q000378:metabolism*; D000818:Animals; D008297:Male; D011817:Rabbits; D012980:Sodium Salicylate / Q000493:pharmacokinetics*
D012980:Sodium Salicylate
Farmakokinetika salicylanu u králíků s akutním poskozením ledvin.