title: [Results of therapy of 100 patients with acute leukemia--a retrospective unicenter 5-year analysis].
abstract: The results of therapy in 100 patients who newly fell ill (68 AML, 32 ALL) with acute leukaemia were evaluated (1981 to 1985). The 5-year-survival chance of all patients is 15% for AML, 18% for ALL, first of all it is depending on the degree of remission obtained. The CR rate is nearly 43% (AML) and 66% (ALL), respectively, shows a dependence upon age and is impaired above all by a high early death rate (supportive therapy). With increasing aggressiveness the results of the remission induction therapy improve, as it becomes clear in a comparison with an evaluation of patients 1965-1980 (CR: 15-32%). Also in the postremission therapy the results of intensive forms of therapy are more favourable: 4 years recurrence-free survival after CR in autologous bone marrow transplantation 50%, in allogenic bone marrow transplantation 40%, in cyclic chemotherapy 17%, in oral permanent therapy 0%. Starting from these findings the present conception of the therapy of acute leukaemias is discussed in connection with the literature.
authors.affiliation: Abteilung für Hämatologie und Onkologie, Karl-Marx-Universität Leipzig.
authors.forename: M
authors.initials: M
authors.lastname: Kubel
authors.forename: W
authors.initials: W
authors.lastname: Helbig
authors.forename: H
authors.initials: H
authors.lastname: Schwenke
authors.forename: F A
authors.initials: FA
authors.lastname: Hoffmann
authors.forename: S
authors.initials: S
authors.lastname: Leiblein
authors.forename: E
authors.initials: E
authors.lastname: Schulze
authors.forename: W
authors.initials: W
authors.lastname: Pönisch
authors.forename: R
authors.initials: R
authors.lastname: Krahl
authors.forename: B
authors.initials: B
authors.lastname: Zuleger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012074:Remission Induction; D012189:Retrospective Studies
vernacular_title: Therapieergebnisse bei 100 Patienten mit akuter Leukämie--eine retrospektive unizentrische 5-Jahres-Analyse.