[Study of the efficiency and stability of harringtonine encapsulation in whole phospholipid vesicle from human erythrocyte membrane].
The whole phospholipid of human erythrocyte membrane was used to prepare small unilamellar vesicles (SUV) of harringtonine by reversed phase evaporation combined with sonication scattering method. The percentage of harringtonine encapsulation and its stability were also studied. The results showed that the concentration of phospholipid and its degree of oxidation were the main influencing factors. The percentage of harringtonine encapsulation under our experimental conditions reached 21.5%. Stability test showed that the rate of leakage of harringtonine from liposome was 7.3% when stored at 4 degrees C for two months.
Yang
X F
XF
Ma
Y F
YF
Chen
Z Q
ZQ
Fan
Q X
QX
D000470:Alkaloids / Q000008:administration & dosage*; D004337:Drug Carriers; D004355:Drug Stability; D004910:Erythrocyte Membrane; D006248:Harringtonines / Q000008:administration & dosage*; D006801:Humans; D008081:Liposomes; D010743:Phospholipids
D000470:Alkaloids; D004337:Drug Carriers; D006248:Harringtonines; D008081:Liposomes; D010743:Phospholipids