The Salmonella mutagenicity test: evaluation of 29 drug candidates.
The Salmonella mutagenicity test (Ames assay) is part of the routine screening battery applied to all new drugs at The Upjohn Company. The purpose of this paper is to report results for 29 compounds. These compounds are very diverse in chemical structure and represent classes of compounds selected because of known biological activity and other reasons. None of the compounds reported here produced an increase in revertant colonies in the Salmonella strains employed (TA98, TA100, TA1535, TA1537 and TA1538) and therefore the Salmonella mutagenicity results with these materials do not suggest potential for mutagenesis or carcinogenesis.
Aaron
C S
CS
Genetic Toxicology Branch, Upjohn Company, Kalamazoo, MI 49001.
Mazurek
J
J
Zimmer
D M
DM
Swenson
D H
DH
D000818:Animals; D001140:Aroclors / Q000494:pharmacology; D001711:Biotransformation; D002478:Cells, Cultured; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000493:pharmacokinetics; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics*
D001140:Aroclors; D009153:Mutagens