title: Experimental uses of flunixin meglumine and phenylbutazone in food-producing animals.
abstract: Presently, in the United States, there are no nonsteroidal anti-inflammatory drugs, except aspirin, that are approved for use in animals intended for food production. Use of phenylbutazone, flunixin meglumine, and dipyrone for treatment of food animals may be considered in special circumstances. Such use requires strict adherence to FDA guidelines for extra-label use of drugs. Flunixin meglumine and phenylbutazone have been shown to have a favorable influence on the course and outcome of certain diseases. This report reviews information concerning the pharmacology, pharmacokinetics, and therapeutics of phenylbutazone and flunixin as they have been used on an experimental basis in food animals.
authors.affiliation: Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824.
authors.forename: M
authors.initials: M
authors.lastname: Kopcha
authors.forename: A S
authors.initials: AS
authors.lastname: Ahl
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy; D002645:Chickens; D003002:Clonixin / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D006041:Goats; D009539:Nicotinic Acids / Q000627:therapeutic use*; D010653:Phenylbutazone / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000188:drug therapy; D012140:Respiratory Tract Diseases / Q000188:drug therapy / Q000662:veterinary; D012756:Sheep; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009539:Nicotinic Acids; C014558:flunixin meglumine; D010653:Phenylbutazone; D003002:Clonixin