Molecular cardiology: new avenues for the diagnosis and treatment of cardiovascular disease.
This review summarizes some of the major advances in the investigation of molecular mechanisms underlying both normal and abnormal cardiovascular function. Four major areas are highlighted including cardiac muscle, the blood vessel, atherosclerosis and thrombosis/thrombolysis. The remarkable strides in understanding multifactorial diseases such as atherosclerosis, and the development of innovative new therapies such as the use of thrombolytic agents produced by recombinant deoxyribonucleic acid (DNA) technology, are noted. Moreover, it is concluded that the past decade of basic research has provided a solid framework for improvements in the diagnosis and therapy of other forms of cardiovascular disease as well. An evaluation of current trends in basic cardiovascular research suggests that diagnostic and therapeutic approaches to disease will increasingly target specific molecular processes underlying the pathophysiologic state.
Hathaway
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Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis 46223.
March
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D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000628:therapy*; D003331:Coronary Vessels / Q000503:physiopathology; D004274:DNA, Recombinant; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D009131:Muscle, Smooth, Vascular; D009132:Muscles / Q000503:physiopathology; D013927:Thrombosis / Q000503:physiopathology
D004274:DNA, Recombinant