Cellular reactions to polyester arterial prostheses impregnated with cross-linked albumin: in vivo studies in mice.
This study was designed to assess the possible immunological responses in mice against polyester prostheses coated with albumin and previously stabilized either with cross-linked glutaraldehyde (GA), at different concentrations, or with carbodiimide (CDI). Prosthetic discs were first implanted in the peritoneal cavities of mice, and T cells and T cell subsets (helper, suppressor, la-bearing T lymphocytes) were then quantified before implantation and at 1, 2, 3 and 4 weeks post-implantation. The percentages of T cells, subsets, and the helper/suppressor cell ratio, as well as the percentage of T cells with la receptors, were similar to the control in all experimental groups. No significant difference and no correlation were observed between the groups wherever tested. Virgin and albumin-coated grafts did not induce any quantitative changes in T cell subpopulations in mice.
Merhi
Y
Y
Laboratoire de Chirurgie Expérimentale, Université Laval, Québec, Canada.
Roy
R
R
Guidoin
R
R
Hebert
J
J
Mourad
W
W
Benslimane
S
S
D000418:Albumins; D000818:Animals; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D005549:Foreign-Body Reaction / Q000276:immunology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011091:Polyesters; D013601:T-Lymphocytes / Q000145:classification*
D000418:Albumins; D001672:Biocompatible Materials; D011091:Polyesters