title: Similarity between tyrosyl-tRNA synthetase and the estrogen receptor.
abstract: Residues 1-42 of Escherichia coli tyrosyl-tRNA synthetase are similar to residues 293-334 of the human estrogen receptor. A computer analysis yields a comparison score that is 8.2 standard deviations higher than that obtained with 10,000 comparisons of randomized sequences of these segments (P = 1.2 X 10(-16). This part of tyrosyl-tRNA synthetase binds ATP, which suggests that residues 293-334 of the human estrogen receptor are part of an ATP binding site.
authors.affiliation: Department of Medicine, University of California, San Diego, La Jolla 92093.
authors.forename: M E
authors.initials: ME
authors.lastname: Baker
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000595:Amino Acid Sequence; D000604:Amino Acyl-tRNA Synthetases / Q000235:genetics*; D001665:Binding Sites; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D011960:Receptors, Estrogen / Q000235:genetics*; D014448:Tyrosine-tRNA Ligase / Q000235:genetics*
chemical_list: D011960:Receptors, Estrogen; D000255:Adenosine Triphosphate; D000604:Amino Acyl-tRNA Synthetases; D014448:Tyrosine-tRNA Ligase