Severe impairment of coronary reserve during rejection in patients with orthotopic heart transplant.
The present study analyzed coronary sinus blood flow alterations after dipyridamole induced coronary vasodilation in seven patients whose endomyocardial biopsies evidenced no sign of rejection (group 1) and in five patients with histologic signs of rejection (group 2) after orthotopic heart transplantation. All patients were treated with cyclosporine and prednisone and some with azathioprine and had normal coronary arteriograms. Coronary sinus blood flow and coronary resistance were measured before and after intravenous dipyridamole (0.18 mg/kg/min over 4 minutes). Basal values were similar in groups 1 and 2 for coronary sinus blood flow (166 +/- 34 compared with 181 +/- 39 ml/min, respectively), coronary resistance (0.62 +/- 10 compared with 0.52 +/- 13 mm Hg/ml/min, respectively), coronary sinus blood oxygen content (5.7 +/- 1.6 compared with 4.5 +/- 0.9 ml/100 ml, respectively) and arterial-coronary sinus blood oxygen difference (10.6 +/- 1.3 compared with 10.3 +/- 1.8 ml/100 ml, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
Nitenberg
A
A
Service d'Explorations Fonctionnelles, INSERM U.251, CHU Xavier Bichat, Paris, France.
Tavolaro
O
O
Loisance
D
D
Foult
J M
JM
Benhaiem
N
N
Cachera
J P
JP
D000792:Angiography; D001706:Biopsy; D003326:Coronary Circulation / Q000187:drug effects; D004176:Dipyridamole / Q000627:therapeutic use; D006084:Graft Rejection; D016027:Heart Transplantation; D006439:Hemodynamics; D006801:Humans; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010100:Oxygen / Q000097:blood; D014655:Vascular Resistance; D014664:Vasodilation
D004176:Dipyridamole; D010100:Oxygen