The role of allogeneic epidermis in murine graft rejection.
Skin equivalents containing allogeneic fibroblasts in a collagen matrix and overlaid with isologous epidermal cells have been successfully grafted to rodents. By contrast, skin equivalents containing isologous fibroblasts and allogeneic epidermal cells provoke a strong rejection response, characterized by the infiltration of mononuclear cells into the epidermis at 1 week and occlusion of the microvasculature and destruction of the epidermis by lymphocytes 2 weeks after grafting. Based on these findings, skin equivalents containing allogeneic fibroblasts could be used in the treatment of burn injuries, but the epidermis should be obtained from the patient.
Lerner-Tung
M B
MB
Department of Biological Sciences, Wright State University, Dayton, OH 45435.
Hull
B E
BE
D000818:Animals; D003094:Collagen / Q000032:analysis; D046508:Culture Techniques; D004817:Epidermis / Q000276:immunology*; D005347:Fibroblasts / Q000276:immunology / Q000473:pathology; D006084:Graft Rejection; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats; D011916:Rats, Inbred F344; D012867:Skin / Q000276:immunology / Q000473:pathology; D016038:Skin Transplantation
D003094:Collagen