Growth hormone: past, present, and future.
Recent progress in the diagnosis and therapy of IGHD illustrates the ever-increasing influence of recombinant DNA research. Recombinant DNA technology has already resulted in the synthesis of therapeutic growth hormone that is both relatively easy to produce and safe. Recombinant DNA probes have also been developed that can clearly diagnose one form of growth hormone deficiency (IGHD-1A) and are approaching identification of other forms. Finally, since they function by direct interaction with the genes, probes will also detect the precise molecular defect(s) causing IGHD. This knowledge potentially could lead to a means of correcting the mutations themselves.
Schaefer
F V
FV
Swartz-Boyd
J
J
Wilson
D P
DP
D015342:DNA Probes; D005544:Forecasting; D006130:Growth Disorders / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D013006:Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use
D015342:DNA Probes; D011994:Recombinant Proteins; D013006:Growth Hormone