title: The in vitro effect of methylmercuric chloride on superoxide dismutase activity of pig platelets.
abstract: Incubation of the suspension of washed pig platelets with methylmercuric chloride (MeHg) caused decrease of superoxide dismutase (SOD) activity at the concentrations of MeHg 10(-5)-10(-4) mol/l. We also observed the increase of enzyme activity at low concentrations of MeHg (10(-7)-10(-6) mol/l). MeHg affects the SOD activity similarly to other mercurials which are known to react with sulfhydryl groups, and differentially influence enzymatic systems.
authors.affiliation: Department of Biochemistry, Medical Academy, Lódź, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Kostka
authors.forename: U
authors.initials: U
authors.lastname: Krajewska
authors.forename: K
authors.initials: K
authors.lastname: Lipecka
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D066298:In Vitro Techniques; D008767:Methylmercury Compounds / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood*; D013552:Swine
chemical_list: D008767:Methylmercury Compounds; D013482:Superoxide Dismutase; C004925:methylmercuric chloride