[Properties and activation mechanism of neutrophilic leukocytes].
The mechanism of neutrophil activation by chemotactic receptor agonists was studied by monitoring stimulus-induced changes in the cytosolic free calcium concentration and hydrogen peroxide formation during the respiratory burst. Two receptor-dependent signal transduction sequences were identified. One sequence depends on calcium, phospholipase C and protein kinase C, and is rate limiting, while the other is comparatively fast and appears to be calcium-independent. The present studies indicate that both sequences must act in concert to transduce receptor-mediated signals and to activate the NADPH oxidase.
Baggiolini
M
M
Theodor-Kocher-Institut, Universität Bern, Schweiz.
Deranleau
D A
DA
Dewald
B
B
Thelen
M
M
von Tscharner
V
V
Wymann
M P
MP
D000818:Animals; D006801:Humans; D008213:Lymphocyte Activation; D009504:Neutrophils / Q000502:physiology*
Eigenschaften und Aktivierungsmechanismus des neutrophilen Leukozyten.