Adverse effects of fenfluramine in treatment refractory schizophrenia.
Fenfluramine was administered to eight severely ill schizophrenic patients as an adjunct to neuroleptic drugs in a double-blind, multiple baseline design. A significant adverse effect of fenfluramine on psychopathology was detected through nurses' ratings, target symptom scales, the Brief Psychiatric Rating Scale, and time-sampled behavioral observations. Clinical deterioration was correlated with fenfluramine-induced reductions in blood serotonin levels and persisted beyond the point of discontinuation of fenfluramine.
Marshall
B D
BD
Department of Psychology, University of California, Los Angeles.
Glynn
S M
SM
Midha
K K
KK
Hubbard
J W
JW
Bowen
L L
LL
Banzett
L
L
Mintz
J
J
Liberman
R P
RP
D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005277:Fenfluramine / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011897:Random Allocation; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012701:Serotonin / Q000097:blood
D005277:Fenfluramine; D012701:Serotonin