The use of bone marrow cells grown in long-term culture for autologous bone marrow transplantation in acute myeloid leukaemia: an update.
Eleven patients with acute myeloid leukaemia have been transplanted with autologous marrow grown in long-term bone marrow culture. In the high risk group (six patients who had all previously relapsed) the procedure induced a remission in two patients who were in florid relapse at the time of the transplant. Five patients were transplanted in first remission and they remain well and disease-free between 150 and 12 weeks after their autologous transplant.
Chang
J
J
Department of Experimental Haematology, Paterson Institute, Christie Hospital, Manchester, UK.
Morgenstern
G R
GR
Coutinho
L H
LH
Scarffe
J H
JH
Carr
T
T
Deakin
D P
DP
Testa
N G
NG
Dexter
T M
TM
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002478:Cells, Cultured; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D010865:Pilot Projects; D012074:Remission Induction; D012306:Risk; D013866:Thioguanine / Q000008:administration & dosage; D014182:Transplantation, Autologous
D003561:Cytarabine; D013866:Thioguanine; D003630:Daunorubicin