title: [Duffy blood groups and HLA antigens in hereditary motor-sensory neuropathy].
abstract: The Duffa system (Fya Fyb) and HLA antigens were examined in 86 subjects (39 affected, 47 healthy) in 17 families with HMSN type I, II and III. They recorded the incidence of autosomal dominant as well as recessive (possibly sporadic) forms. In the autosomal dominant form of HMSN type I a close relationship was detected between genes coding the investigated disease and blood cell signs Fya and Fyb. Recombination was found only in 9.1% of the cases. Investigation HLA antigens revealed marked reduction of the B27 antigen in the investigated patients. A striking sign in families with the autosomal dominant form of HMSN type I was an identical haplotype of the majority of parents.
authors.forename: S
authors.initials: S
authors.lastname: Nevsímalová
authors.forename: J
authors.initials: J
authors.lastname: Prazák
authors.forename: P
authors.initials: P
authors.lastname: Herzog
authors.forename: E
authors.initials: E
authors.lastname: Seemanová
mesh_terms: D001789:Blood Group Antigens / Q000235:genetics*; D004375:Duffy Blood-Group System / Q000235:genetics*; D005260:Female; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000097:blood / Q000235:genetics*; D015417:Hereditary Sensory and Motor Neuropathy / Q000097:blood / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree
chemical_list: D001789:Blood Group Antigens; D004375:Duffy Blood-Group System; D006680:HLA Antigens
vernacular_title: Studie krevní skupiny Duffy a HLA antigenů u hereditární motoricko-senzorické neuropatie.