A case of fatal pemphigus vulgaris in association with beta interferon and interleukin-2 therapy.
Beta interferon (beta-IFN) and interleukin-2 (IL-2) have been utilized in experimental cancer therapy because of their effects on the immune system. We report here a patient treated with IL-2 and beta-IFN who rapidly developed an immune-mediated, bullous exfoliative dermatitis and who ultimately died. Various etiologic mechanisms are proposed.
Ramseur
W L
WL
Bowman Gray School of Medicine, Winston-Salem, North Carolina.
Richards
F
F
Duggan
D B
DB
D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects* / Q000627:therapeutic use; D007376:Interleukin-2 / Q000009:adverse effects* / Q000627:therapeutic use; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000139:chemically induced*
D007370:Interferon Type I; D007376:Interleukin-2