Chromosome segregation from cell hybrids. VI. Centromeres of both parental chromosome sets stain with antikinetochore antibody.
Antikinetochore antibodies obtained from serum of patients with the CREST syndrome of scleroderma were used to test the hypothesis that there are differences in protein binding to retained- and segregant-set centromeres in Chinese hamster--human hybrids. This hypothesis is not supported since identical staining of the two types of kinetochores was observed with CREST antibody.
Zelesco
P A
PA
Department of Genetics and Human Variation, La Trobe University, Bundoora, Australia.
Graves
J A
JA
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D002460:Cell Line; D002503:Centromere / Q000648:ultrastructure*; D002875:Chromosomes / Q000648:ultrastructure*; D006224:Cricetinae; D005455:Fluorescent Antibody Technique; D006801:Humans; D006822:Hybrid Cells / Q000648:ultrastructure*; D008938:Mitosis; D012595:Scleroderma, Systemic / Q000276:immunology
D001323:Autoantibodies