Plasmid-associated adherence of Shigella flexneri in a HeLa cell model.
The initial interaction of Shigella flexneri with HeLa cells was studied at 4 degrees C, a temperature that inhibits parasite-directed endocytosis. It was found that invasive strains were 10-fold more adherent to HeLa cells than were isogenic, noninvasive strains which had lost a 140-megadalton plasmid. Adherent strains were also more hydrophobic than were nonadherent strains.
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Department of Enteric Infections, Walter Reed Army Institute of Research, Washington, D.C. 20307.
Hale
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D001422:Bacterial Adhesion; D006367:HeLa Cells / Q000382:microbiology*; D006801:Humans; D008954:Models, Biological; D010641:Phenotype; D010957:Plasmids; D012763:Shigella flexneri / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology