Effect of repeated benzene inhalation exposures on subsequent metabolism of benzene.
Benzene is a known human leukemogen and animal carcinogen. To better assess the risks associated with benzene exposure, it would be helpful to determine whether repeated inhalation exposures would affect the metabolism of benzene. The purpose of these experiments was to determine if exposure of F344 rats and B6C3F1 mice to 600 ppm benzene, 6 h/day, 5 days/week for 3 weeks, would affect the subsequent in vivo metabolism of inhaled [14C]benzene.
Sabourin
P J
PJ
Lovelace Inhalation Toxicology Research Institute, Albuquerque, NM 87185.
Sun
J D
JD
Birnbaum
L S
LS
Lucier
G
G
Henderson
R F
RF
D000280:Administration, Inhalation; D000818:Animals; D001554:Benzene / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D002250:Carbon Radioisotopes / Q000378:metabolism; D004781:Environmental Exposure; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011916:Rats, Inbred F344
D002250:Carbon Radioisotopes; D001554:Benzene