[Differential immunohistochemical characteristics of meningiomas and other neoplasms of the central nervous system].
We present an immunohistochemical study of 16 meningiomas and 19 CNS tumors including gliomas, neurinomas and metastatic carcinomas, in order to establish a histopathologic differential diagnosis, using formalin-fixed and paraffin-embedded material. The antibodies analysed included vimentin, GFA-protein, cytokeratin, S-100 protein and epithelial membrane antigen. Meningiomas always express vimentin as marker, and occasionally cytokeratin and EMA. The most constant antigens demonstrated in astrocytomas were GFA-protein and vimentin, and occasionally we were able to detect S-100 protein. Neurinomas proved positive to S-100 protein, and metastases presented cytokeratin and EMA reactivity. Our results confirm the existence of diverse immunohistochemical patterns within CNS tumors, a fact that can be useful in routine differential diagnosis.
Pérez-Bacete
M J
MJ
Cerdá-Nicolás
M
M
Piquer
J
J
Peydró-Olaya
A
A
D001254:Astrocytoma / Q000032:analysis / Q000473:pathology*; D001932:Brain Neoplasms / Q000032:analysis / Q000473:pathology* / Q000556:secondary; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008577:Meningeal Neoplasms / Q000032:analysis / Q000473:pathology*; D008579:Meningioma / Q000032:analysis / Q000473:pathology*; D009442:Neurilemmoma / Q000032:analysis / Q000473:pathology*
Características inmunohistoquímicas diferenciales de los meningiomas con otras neoplasias del S.N.C.