A rare fast variant of red cell 6-phosphogluconate dehydrogenase found in Japanese.
In a Japanese family, we discovered by starch-gel electrophoresis a fast variant of 6-phosphogluconate dehydrogenase (PGD) in red blood cells. This variant is described here for the first time and temporarily named AX. It showed three PGD bands, the usual PGD A band and two faster-moving bands than PGD A. The ratio of the staining intensity of these bands was 2:2:1 in the order of increasing mobility, and negative sensitivity was noted toward 2-mercaptoethanol. Its genotype appeared to be heterozygous PGDA/PGDX, based on examinations of the PGD band composition and the pedigree of the family. It may possibly correspond to the PGD "Kadar" variant (PGDA/PGDKadar), with which it was quite similar, in electrophoretic mobility, staining intensity and sensitivity to 2-mercaptoethanol.
Tsunoda
K
K
Douge
K
K
Kuroiwa
Y
Y
Watanabe
S
S
Watanabe
T
T
D044466:Asian People / Q000235:genetics*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D010334:Paternity; D010375:Pedigree; D010734:Phosphogluconate Dehydrogenase / Q000097:blood / Q000235:genetics*
D010734:Phosphogluconate Dehydrogenase