title: Sodium hyaluronate in the treatment of keratoconjunctivitis sicca. A double masked clinical trial.
abstract: The effect of sodium hyaluronate eye drops in the treatment of severe keratoconjunctivitis sicca (KCS) was evaluated in a double masked crossover trial, comparing the effect of a 0.1% solution, a 0.2% solution and placebo in 20 patients. We found significantly decreased rose bengal staining and increased break-up time following 0.2% treatment compared to placebo. No significant difference was found in the Schirmer values and the cornea sensitivity. The patients significantly preferred sodium hyaluronate treatment. We conclude that sodium hyaluronate eye drops seem to be a valuable new agent in the management of KCS.
authors.affiliation: Department of Ophthalmology, Hvidovre Hospital, University of Copenhagen, Denmark.
authors.forename: B B
authors.initials: BB
authors.lastname: Sand
authors.forename: K
authors.initials: K
authors.lastname: Marner
authors.forename: M S
authors.initials: MS
authors.lastname: Norn
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007637:Keratoconjunctivitis / Q000188:drug therapy*; D007638:Keratoconjunctivitis Sicca / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011897:Random Allocation
chemical_list: D009883:Ophthalmic Solutions; D006820:Hyaluronic Acid