[Synthesis and anticonvulsive activity of some new bisubstituted 1,3,4-oxadiazoles and 1H-1,2,4-triazoles].
The synthesis of 7 new 2-[(2-alkoxy-3-methoxyphenyl) methyl]-5-arylamino-1,3,4 oxadiazoles by cyclisation of the corresponding thiosemicarbazides is described. Some of these were tested for anticonvulsant activity. The compound 2-[(2-butoxy-3-methoxy phenyl) methyl]-5-phenylamino 1,3,4-oxadiazole has shown significant anticonvulsant potency. A few new 3-phenyl-5-[(2-alkoxy-3-methoxy phenyl) methyl]-1H-1,2,4 triazoles have also been synthesized.
Tsitsa
P
P
Papadaki-Valiraki
A
A
Siatra-Papastaikoudi
T
T
Papadopoulou-Daifoiti
Z
Z
Vamvakidis
A
A
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D008297:Male; D051379:Mice; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology*
D000927:Anticonvulsants; D010069:Oxadiazoles; D014230:Triazoles
Synthèse et activité anticonvulsivante de quelques nouveaux oxadiazoles-1,3,4 et 1H-triazoles-1,2,4 disubstitués.