title: [An improvement in insulin efficacy in patients with type-1 diabetes mellitus following treatment using an insulin infusion pump].
abstract: In 8 patients with diabetes mellitus type I two methods for intensified insulin treatment were compared: method of numerous insulin applications and treatment with a subcutaneous insulin pump (Microjet model of "Miles" company). The following were taken into consideration: daily insulin dose, residuary beta-cell secretion (determined by a venous Tolbutamide test and dynamic follow up of C-peptide), peripherial insulin efficiency (M) determined in vivo by an euglycemic hyperinsulinemic clamp-technique (Biostator). The infusion pump treatment imitates the beta-cell function better than the numerous insulin applications. This method of treatment helps in overcoming the insulin deficiency and the jatrogenic hyperinsulinemia and as a result the metabolic compensation and insulin efficiency are improved.
authors.forename: A M
authors.initials: AM
authors.lastname: Borisova
authors.forename: D
authors.initials: D
authors.lastname: Koev
authors.forename: G
authors.initials: G
authors.lastname: Kirilov
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004341:Drug Evaluation; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D007332:Insulin Infusion Systems; D014044:Tolbutamide
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D014044:Tolbutamide
vernacular_title: Podobriavane na insulinovata efektivnost pri bolni sŭs zakharna bolest tip I sled lechenie s insulinova infuzionna pompa.