title: Gingival response to nicotine polacrilex.
abstract: Nicotine polacrilex (Nicorette) is the only medication approved by the Food and Drug Administration for tobacco dependency treatment. It is available only by prescription. This study sought to determine whether this medication produced any adverse gingival effects. Thirty-one patients (91%) used the nicotine polacrilex for at least 1 month and 20 (59%) for 3 months or more. Five (15%) developed small (less than 2 mm), painless, clear, nonhemorrhagic vesicles which resolved immediately when patients were reinstructed to position the medication in different sites in the mouth. There were no changes in gingival color, contour, consistency and texture, tooth mobility, or periodontal pocket depth. Nicotine polacrilex does not appear to have any significant adverse effects on the gingiva even with up to 6 months of daily use.
authors.affiliation: Division of Respiratory Therapy, Stanford University, School of Medicine, CA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Silver
authors.forename: D P
authors.initials: DP
authors.lastname: Sachs
authors.forename: T L
authors.initials: TL
authors.lastname: Hottel
mesh_terms: D002638:Chewing Gum / Q000009:adverse effects*; D005881:Gingiva / Q000187:drug effects*; D005888:Gingival Pocket / Q000473:pathology; D006801:Humans; D015337:Multicenter Studies as Topic; D009538:Nicotine / Q000009:adverse effects / Q000031:analogs & derivatives*; D011109:Polymethacrylic Acids / Q000009:adverse effects*; D011145:Polyvinyls / Q000009:adverse effects*; D011446:Prospective Studies; D061485:Tobacco Use Cessation Devices
chemical_list: D002638:Chewing Gum; D011109:Polymethacrylic Acids; D011145:Polyvinyls; D009538:Nicotine