Acquisition and processing of a conditional dicentric chromosome in Saccharomyces cerevisiae.
The introduction of a conditional centromere into chromosome III of Saccharomyces cerevisiae provided an opportunity to evaluate phenotypic and karyotypic consequences in cells harboring dicentric chromosomes upon entry into mitosis. A mitotic pause ensued, and monocentric derivatives of chromosome III were generated at a high frequency.
Hill
A
A
Department of Biology, University of North Carolina, Chapel Hill 27599-3280.
Bloom
K
K
D002503:Centromere / Q000648:ultrastructure; D002872:Chromosome Deletion; D002875:Chromosomes / Q000648:ultrastructure*; D007621:Karyotyping; D008938:Mitosis; D010641:Phenotype; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000648:ultrastructure*