title: [Cardiopathy in Noonan syndrome. Review of 29 cases].
abstract: Twenty nine cases, nineteen females and ten males of Noonan's syndrome are reported. The age at diagnosis ranged from five months to 11.5 years (median age: 56 months). Fifteen cases 57% disclose aspects of the Noonan's phenotype in female siblings. Fourteen cases showed an associated cardiopathy. The total included eleven pulmonary valve stenosis, five atrial septal defect. three hypertrophic myocardiopathies, three ventricular septal defect, one patients with pulmonary stenosis manifested an associated situs inversus this concomitance is the first reported in Noonan's syndrome. Eight patients underwent surgery, and two valvuloplasties. We can conclude that Noonan's syndrome includes cardiopathy in 50% of patients the most frequent type is pulmonary valve stenosis. On going follow-up will permit to evaluate the clinical evolution of the hypertrophic cardiomyopathy.
authors.affiliation: Cardiología Pediátrica, Hospital Infantil de Cruces, Baracaldo, Vizcaya.
authors.forename: J
authors.initials: J
authors.lastname: Zubeldia Sánchez
authors.forename: A
authors.initials: A
authors.lastname: Cabrera Duro
authors.forename: M
authors.initials: M
authors.lastname: Sánchez Obregón
authors.forename: J
authors.initials: J
authors.lastname: Pilar Uribe
authors.forename: M
authors.initials: M
authors.lastname: Sarrionandia Uribelarrea
authors.forename: M J
authors.initials: MJ
authors.lastname: Sebastián Ruiz
authors.forename: L
authors.initials: L
authors.lastname: Benito Basanta
mesh_terms: D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009634:Noonan Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology; D011859:Radiography
vernacular_title: Cardiopatía en el síndrome de Noonan. Revisión de 29 casos.