A study on the role of zinc on the immune response and body metabolism--a contribution of trace elements.
The role of zinc in the control of lymphocyte function, especially immune response was studied. Zinc inhibited pokeweed mitogen (PWM)-induced generation of immunoglobulin secreting cells (ISC) apparently by a non-specific activation of T cells involving both CD4 and CD8 cells as well as both CD8-Leu8+ and CD8-Leu8- cells. Lymphocyte proliferation was inhibited by anti-IL2 receptor and anti-IL2 antibodies as well, indicating that zinc augments signal transduction through IL2 receptors through enhancement of the interaction between the IL2 and IL2 receptors. Zinc induced high affinity receptors for IL2 on lymphocytes.
Tanaka
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Y
D000921:Antibody-Producing Cells / Q000276:immunology; D002478:Cells, Cultured; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects*; D015375:Receptors, Interleukin-2 / Q000187:drug effects / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology*
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D015032:Zinc