Tricyclic antidepressants block N-methyl-D-aspartic acid-induced lethality in mice.
It has been suggested on the basis of in vitro studies that tricyclic antidepressants interact with the N-methyl-D-aspartic acid (NMDA)-receptor complex to block the action of NMDA. The present study showed that tricyclic antidepressants prevented lethality produced by a large dose of NMDA. The potency of the drugs in preventing NMDA-induced lethality correlated with the inhibition of [3H]-MK-801 binding at the NMDA receptor complex, and not with effects on amine uptake. These in vivo data support the in vitro data of Reynolds & Miller (1988a,b).
Leander
J D
JD
Central Nervous System Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000633:toxicity; D008297:Male; D051379:Mice; D016202:N-Methylaspartate
D000929:Antidepressive Agents, Tricyclic; D001224:Aspartic Acid; D016202:N-Methylaspartate