title: [Effect of tourniquet ischemia of the arm on changes in selected parameters of muscle metabolism].
abstract: Pneumatic cuff with manometer has become a routine apparatus being applied in surgery of the hand. Ischaemia of the upper extremity procured by means of pneumatic cuff with controlled pressure maintained for 30 minutes to 2 hours and 20 minutes appeared to be safe. The following enzymes were studied: lactic dehydrogenase (LDH) creatine kinase (CPK), aldolase and total protein as well as its electrophoretic decomposition, moreover seromucoid and also 9 selected glycoproteins. There were changes indicating metabolic disturbances during the time from the 3 rd h. upon the removal of the cuff to as late as the third 24-hours inclusive. Significant deviations were disclosed with regard to the rise in levels of: creatine kinase, alpha 1 and alpha 2 globulins, protein of acute phase (inflammatory)--seromucoid and 5 glycoproteins as well as a drop in albumins level. The rise in the value of metabolic enzymes was more significant when the application of the cuff was longer than 1 hour. A similar behaviour was observed in some of the selected glycoproteins qualified to the acute phase proteins. In patients, in whom the cuff was applied for 2 hours or longer, there were transient side effects of ischaemia, which under proper management terminated without traces. In own material neither local nor general permanent changes were noted after imposed ischaemia, which is ample evidence that the technique of ischaemia used in the cited time compartments is safe and useful in surgical procedure involving the extremities particularly the upper ones. Nevertheless, disclosed deviations in a number of metabolic parameters show that some injury to ischaemic tissues is found to take place.
authors.forename: S
authors.initials: S
authors.lastname: Rupiński
mesh_terms: D001132:Arm / Q000098:blood supply*; D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D006230:Hand Injuries / Q000601:surgery*; D006488:Hemostasis, Surgical; D006801:Humans; D007511:Ischemia / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism; D009132:Muscles / Q000098:blood supply / Q000378:metabolism*; D014111:Tourniquets
chemical_list: D009124:Muscle Proteins; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase
vernacular_title: Wpływ planowego niedokrwienia kończyny górnej na zachowanie sie wybranych parametrów metabolizmu mieśni.