Plasma lipids in patients with type I diabetes mellitus. Influence of race, gender, and plasma glucose control: lipids do not correlate with glucose control in black women.
Plasma lipids and hemoglobin A1 were measured in 544 type I diabetic patients. Hemoglobin A1 was positively correlated with the levels of total plasma cholesterol, total triglycerides, and low-density lipoprotein cholesterol and negatively correlated with the level of high-density lipoprotein cholesterol in the entire biracial group. These relationships between plasma lipids and hemoglobin A1 were not present in black women. In the white diabetic population a reduction in hemoglobin A1 of one percentage point was statistically associated with a decrease of 0.16 to 0.17 mmol/L in total plasma cholesterol, a decrease of 0.10 to 0.13 mmol/L in low-density lipoprotein cholesterol, and a reduction of 0.12 to 0.14 mmol/L in triglycerides. These findings suggest that race and gender are important determinants of the response of plasma lipids to glucose control in type I diabetes mellitus.
Semenkovich
C F
CF
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110.
Ostlund
R E
RE
Schechtman
K B
KB
D000293:Adolescent; D000328:Adult; D044383:Black People; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000208:ethnology*; D005260:Female; D006441:Hemoglobin A / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D008055:Lipids / Q000097:blood*; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D014481:United States; D001741:Black or African American
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D008055:Lipids; D014280:Triglycerides; D006441:Hemoglobin A; D002784:Cholesterol