Homology between surface protein antigen genes of Streptococcus sobrinus and Streptococcus mutans.
The structural gene (pag gene) for a 210 kDa protein antigen of Streptococcus sobrinus serotype g was cloned and compared with that (pac gene) of a 190 kDa protein antigen of Streptococcus mutans serotype c. Immunodiffusion analysis revealed that the product of the pag gene immunologically cross-reacted with that of the pac gene. Southern blot and nucleotide sequence analyses revealed that a significant homology existed between the middle regions of the two structural genes.
Takahashi
I
I
Department of Dental Research, National Institute of Health, Tokyo, Japan.
Okahashi
N
N
Sasakawa
C
C
Yoshikawa
M
M
Hamada
S
S
Koga
T
T
D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000235:genetics*; D000954:Antigens, Surface / Q000235:genetics; D001483:Base Sequence; D015139:Blotting, Southern; D004926:Escherichia coli / Q000235:genetics; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D013291:Streptococcus / Q000235:genetics* / Q000276:immunology; D013295:Streptococcus mutans / Q000235:genetics* / Q000276:immunology
D000942:Antigens, Bacterial; D000954:Antigens, Surface