title: Homology between surface protein antigen genes of Streptococcus sobrinus and Streptococcus mutans.
abstract: The structural gene (pag gene) for a 210 kDa protein antigen of Streptococcus sobrinus serotype g was cloned and compared with that (pac gene) of a 190 kDa protein antigen of Streptococcus mutans serotype c. Immunodiffusion analysis revealed that the product of the pag gene immunologically cross-reacted with that of the pac gene. Southern blot and nucleotide sequence analyses revealed that a significant homology existed between the middle regions of the two structural genes.
authors.affiliation: Department of Dental Research, National Institute of Health, Tokyo, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Okahashi
authors.forename: C
authors.initials: C
authors.lastname: Sasakawa
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: S
authors.initials: S
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Koga
mesh_terms: D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000235:genetics*; D000954:Antigens, Surface / Q000235:genetics; D001483:Base Sequence; D015139:Blotting, Southern; D004926:Escherichia coli / Q000235:genetics; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D013291:Streptococcus / Q000235:genetics* / Q000276:immunology; D013295:Streptococcus mutans / Q000235:genetics* / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D000954:Antigens, Surface