[Neonatal lupus erythematosus].
The neonatal lupus erythematosus syndrome, first described by McCuistion and Schoch in 1954, is associated with characteristic skin lesions and congenital heart block in the new-born, and the presence of Ro-(SSA), La-(SSB), or RNP antibodies in mothers and infants. A transplacental transference of maternal autoantibodies is discussed as possible pathophysiologic mechanism in neonatal lupus. The symptoms, the onset, and recently published pathogenetic concepts are reviewed.
Mayet
W J
WJ
I. Medizinische Klinik, Universität Mainz.
Hermann
E
E
Bachmann
M
M
Poralla
T
T
Meyer zum Büschenfelde
K H
KH
D000974:Antibodies, Antinuclear / Q000235:genetics / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D012307:Risk Factors
D000974:Antibodies, Antinuclear; D006680:HLA Antigens; C035356:SS-A antibodies; C035357:SS-B antibodies
Neonataler Lupus erythematodes.