Glycine reverses the effect of HA-966 on NMDA responses in cultured rat cortical neurons and in chick retina.
The effects of glycine on NMDA antagonism by a series of excitatory amino acid antagonists were tested in two functional in vitro models: NMDA induced [3H]GABA release from cultured mouse cortical neurons and NMDA evoked spreading depression in chick retina. In both models glycine reversed the NMDA antagonism by HA-966. Also NMDA block by kynurenic acid and by DNQX were partly reversed by glycine. However, CNQX, D-APV, ketamine and MK 801 showed the same NMDA antagonism in the absence and presence of glycine.
Drejer
J
J
Department of Neurochemistry, Ferrosan Research Division, Soeborg, Denmark.
Sheardown
M
M
Nielsen
E O
EO
Honoré
T
T
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D002540:Cerebral Cortex / Q000187:drug effects; D002645:Chickens; D013181:Cortical Spreading Depression / Q000187:drug effects; D005998:Glycine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D066298:In Vitro Techniques; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D012160:Retina / Q000187:drug effects
D011760:Pyrrolidinones; D001224:Aspartic Acid; D016202:N-Methylaspartate; C001369:1-hydroxy-3-amino-2-pyrrolidone; D005998:Glycine