[Clinical studies and ultrastructure in myotonic dystrophy].
The results of clinical and ultrastructural observation on the affected skeletal muscles in myotonic dystrophy are reported. The patients were five males and four females, aged 24-51 years. The symptoms were classical, there are myotonia, muscular atrophy, weakness and other multi-systemic symptoms, etc. Electromyography shown myotonic response. The major features under electron microscope were as follows. The partial sarcomeres shown lysis; there are the sarcoplasmic pads, sarcoplasmic masses; the muscular nuclear are proliferous and its intrude. The posterior membrane of synapse are simplism, etc. The correlations between these ultrastructural changes and pathogenesis were discussed.
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D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000648:ultrastructure*; D009223:Myotonic Dystrophy / Q000235:genetics / Q000473:pathology*; D010375:Pedigree