[120-hour continuous 5-FU infusion and cisplatin in the treatment of advanced esophageal carcinoma--clinical analysis of 19 cases].
From May 1985 to July 1987, 21 patients with advanced esophageal carcinoma without previous chemotherapy were treated with 120-hour continuous 5-FU infusion and Cisplatin. 19 patients received at least one to three cycles of treatment. One achieved complete response (5.5%), 8 partial response (42.1%), 4 no change (22.2%), 6 progressive disease (31.5%). The overall response rate was 47.6% (9/19). The toxic effects were tolerable in most patients. The factors influencing response are discussed. The authors suggest this regime as a palliative treatment or a part of combined therapy for advanced esophageal carcinoma.
Zhang
Z H
ZH
First Hospital, Xian University of Medical Sciences.
D000230:Adenocarcinoma / Q000188:drug therapy*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D008297:Male; D008875:Middle Aged
D002945:Cisplatin; D005472:Fluorouracil