Synthesis of certain heteroaryl-fused pyrimidines and pyridines and selena- and thia-diazoles with naphthyl substituent as potential antifungal agents.
A convenient route is reported for the synthesis of 1,2,3-selenadiazole, 1,2,3-thiadiazole, 1,2,4-triazolo[4,3-a]pyrimidine, tetrazolo[4,5-a]pyrimidine, benzimidazolo[1,2-a]pyrimidine and pyrazolo[3,4-b]pyridine derivatives in which the naphthyl nucleus is incorporated. The preliminary results of antifungal testing are reported.
Moawad
E B
EB
Department of Chemistry, Faculty of Science, University of Mansoura, A.R.E.
Yousif
M Y
MY
Metwally
M A
MA
D000935:Antifungal Agents / Q000138:chemical synthesis*; D001393:Azoles / Q000138:chemical synthesis* / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D012643:Selenium / Q000494:pharmacology; D013777:Tetrazoles / Q000138:chemical synthesis / Q000494:pharmacology; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology
D000935:Antifungal Agents; D001393:Azoles; D001562:Benzimidazoles; D009281:Naphthalenes; D011720:Pyrazoles; D011725:Pyridines; D011743:Pyrimidines; D013777:Tetrazoles; D013830:Thiadiazoles; D014230:Triazoles; D012643:Selenium; C023666:pyridine