title: Investigation on the enantiomeric impurity of epinephrine hydrochloride injections.
abstract: Epinephrine enantiomers were derived into diastereoisomers with the chiral reagent 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosylisothiocyanate. The resolution was carried out on a C18 column. The Rs between (-)-R- and (+)-S-isomers was 2.3. The retention time could be changed by adding a proper amount of acetoinitrile into the mobile phase. The results showed that (+)-S-isomer in the epinephrine hydrochloride injections increased during the period of storage.
authors.affiliation: Wuhan Municipal Institute for Drug Control, China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Yang
authors.forename: R Z
authors.initials: RZ
authors.lastname: Xu
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004837:Epinephrine / Q000302:isolation & purification*; D007202:Indicators and Reagents; D017879:Isothiocyanates; D013237:Stereoisomerism; D013861:Thiocyanates
chemical_list: D007202:Indicators and Reagents; D017879:Isothiocyanates; D013861:Thiocyanates; C041943:2,3,4,6-tetra-O-acetylglucopyranosylisothiocyanate; D004837:Epinephrine