Effect of metronidazole on platelet aggregation.
The effects of metronidazole on platelet aggregation induced by several agonists were studied on guinea pig and human platelet-rich plasma. Metronidazole (0.25-2.5 mg/ml) showed a dose-dependent inhibitory effect on in vitro aggregation of platelets from either source induced by adenosine-5-diphosphate (ADP), platelet aggregating factor (PAF), epinephrine, collagen or convulxin (extracted from Crotalus durissus terrificus venom). Total or partial inhibition was also detected in metronidazole pre-treated guinea pig platelet-rich plasma when challenged with PAF or ADP 45 and 135 min after oral treatment, respectively. This inhibition was both dose and time dependent.
Prado-Franceschi
J
J
Departamento de Farmacologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, SP, Brasil.
Antunes
E
E
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D003435:Crotalid Venoms / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D037181:Lectins, C-Type; D008795:Metronidazole / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
D003435:Crotalid Venoms; D037181:Lectins, C-Type; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D008795:Metronidazole; C028890:convulxin; D000244:Adenosine Diphosphate; D004837:Epinephrine