Effect of injection of different concentrations of lidocaine into the rats salivary glands.
The effects of different doses of lidocaine with or without epinephrine on the rat's salivary glands were studied in this report. 60 adult male albino rats were divided into 4 experimental groups and one control group' 1 st group, the salivary glands were injected with 0.1 ml of 2% lidocaine Hcl. 2 nd group, the salivary glands were injected with 0.5 ml of 2% lidocaine Hcl. 3 rd group, the salivary glands were injected with 0.1 ml of lidocaine Hcl + 1/200,000 epinephrine, while the 4 th group, the glands were injected with 0.1 ml of lidocaine Hcl + 1/80.000 epinephrine. The control group was injected with 0.1 ml of physiologic asline. Each group of animals was subdivided into 3 subgroups A, B, and C according to the sacrifice periods which were 24, 48 and 72 hours respectively. After sacrification the submandibular salivary glands were removed and prepared for histological and histochemical studies. Our results revealed that, lidocaine in relevant doses with or without epinephrine produced reversible damage to the terminal portions of salivary glands. Large doses of lidocaine produced massive damage and delayed healing. Epinephrine concentration of 1/200.000 is recomended by the authors as higher concentration produced sever and extensive damage.
el-Zoghby
S A
SA
el-Zainy
M A
MA
D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology*; D051381:Rats; D012469:Salivary Glands / Q000187:drug effects*
D008012:Lidocaine; D004837:Epinephrine