[Assessment of the antiphlogistic effect of naftifin-HCl in the UV-B erythema test].
In a placebo-controlled double-blind comparative study conducted in 19 healthy volunteers, naftifin hydrochlorid cream was tested against clotrimazole 1%, clotrimazole 1%+hydrocortisone 1%, and various hydrocortisone preparations (0.5%; 1%; 2.5%) for erythema-suppressive effects. The anti-inflammatory effect of naftifine hydrochloride demonstrated earlier was confirmed in this study. The results prove a potency comparable to that of weak topical glucocorticosteroids.
Kecskes
A
A
Department Humanpharmakologie II, Schering AG Berlin.
Jahn
P
P
D000287:Administration, Topical; D000328:Adult; D000499:Allylamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000588:Amines / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003022:Clotrimazole / Q000494:pharmacology; D004311:Double-Blind Method; D006801:Humans; D006854:Hydrocortisone; D012867:Skin / Q000187:drug effects*; D013471:Sunburn / Q000517:prevention & control; D014466:Ultraviolet Rays
D000588:Amines; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D000499:Allylamine; C029178:naftifine; D003022:Clotrimazole; D006854:Hydrocortisone
Nachweis der antiphlogistischen Wirkung von Naftifin-HCl im UV-B-Erythemtest.