Effect of endothelin on renal function in rats.
The effect of synthetic porcine endothelin on glomerular filtration rate, renal plasma flow and electrolyte excretion was studied in rats. Endothelin, 1 nmol/kg body weight given as a bolus, induced a transient decrease in glomerular filtration rate (72%) and in renal plasma flow (76%) as well as in sodium excretion, accompanied by a sustained increase in renal vascular resistance. This dose had no sustained effect on mean arterial pressure. It is concluded that endothelin induces a marked decrease in glomerular filtration rate and renal perfusion. This peptide could play a role in the alterations in renal function observed after renal injury.
López-Farré
A
A
Medical Research Institute, Fundación Jiménez Díaz-Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Montañés
I
I
Millás
I
I
López-Novoa
J M
JM
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D016232:Endothelins; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000187:drug effects; D014563:Urodynamics / Q000187:drug effects
D016232:Endothelins; D010455:Peptides