title: Effector cells involved in nonspecific and antibody-dependent mechanisms directed against Plasmodium falciparum blood stages in vitro.
abstract: We have evaluated in in vitro conditions the possible cooperative effect of antimalarial antibodies with several human blood cell types. When used alone, immunoglobulin G from African adults who had reached a state of premunition against malaria was found to have no or very limited direct effect on invasion and multiplication of P. falciparum asexual blood stages. In contrast, these antibodies induced a marked specific inhibition of parasite growth in the presence of normal blood monocytes, and the inhibition did not appear to be strain dependent. No similar antibody-dependent cellular inhibitory effect was found using human blood polymorphonuclear leukocytes, lymphocytes, platelets, or adherent spleen cells. However, these cells could all exert in vitro some non-antibody-dependent inhibitory effect when present at high effector/target cell ratios.
authors.affiliation: Faculté de Médecine Paris VI, France.
authors.forename: F
authors.initials: F
authors.lastname: Lunel
authors.forename: P
authors.initials: P
authors.lastname: Druilhe
mesh_terms: D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000502:physiology*; D000920:Antibody-Dependent Cell Cytotoxicity; D001792:Blood Platelets / Q000276:immunology / Q000469:parasitology; D002448:Cell Adhesion; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods; D006131:Growth Inhibitors / Q000502:physiology; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D007074:Immunoglobulin G / Q000502:physiology; D008214:Lymphocytes / Q000276:immunology / Q000469:parasitology; D008288:Malaria / Q000097:blood* / Q000276:immunology / Q000469:parasitology; D009000:Monocytes / Q000276:immunology / Q000469:parasitology; D009504:Neutrophils / Q000276:immunology / Q000469:parasitology; D010963:Plasmodium falciparum / Q000254:growth & development / Q000276:immunology*; D013154:Spleen / Q000276:immunology / Q000469:parasitology
chemical_list: D000913:Antibodies, Protozoan; D006131:Growth Inhibitors; D007106:Immune Sera; D007074:Immunoglobulin G