[The effect of a diet containing long-chain fatty acids on the formation of insoluble elastin in the rat aorta].
The paper deals with the influence of long-chain fatty acids on the formation of insoluble elastin in vivo. Oil isolated from the sea fish named flounder has been chosen as the source of those long-chain fatty acids. The diet containing the flounder oil was administered to pregnant rat females. The influence of fatty acids on the formation of insoluble elastin was evaluated according to the percentage changes of insoluble elastin in the aortas of newborn rats and to the changes of the amount of desmosine cross-links in isolated elastin. The administration of the diet with long-chain fatty acids causes no changes in the content of elastin in the aortas of the new-born rats, meanwhile the amount of desmosine increases considerably. The results on the aortas of new-born rats shown here are in good agreement with the changes on the aortas of 3-month-old rats published in a previous paper.
Wimmerová
J
J
Ustav lékarské biochemie, katedry II. interny, farmakologie a lékarské biochemie, Hradec Králové.
Benesová
J
J
Hartmanová
M
M
Subrtová
D
D
Stoklasová
A
A
Ledvina
M
M
D000818:Animals; D001011:Aorta / Q000378:metabolism*; D004032:Diet; D004549:Elastin / Q000096:biosynthesis*; D005227:Fatty Acids / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D005227:Fatty Acids; D005395:Fish Oils; D004549:Elastin
Vliv diety obsahujici mastné kyseliny s dlouhým retĕzcem na tvorbu nerozpustného elastinu v aortĕ potkanú.