Bovine serum conglutinin is a lectin which binds non-reducing terminal N-acetylglucosamine, mannose and fucose residues.
Carbohydrate recognition by bovine serum conglutinin has been investigated by inhibition and direct binding assays using glycoproteins and polysaccharides from Saccharomyces cerevisiae (baker's yeast), and neoglycolipids derived from N-acetylglucosamine oligomers, mannobiose and human milk oligosaccharides. The results clearly show that conglutinin is a lectin which binds terminal N-acetylglucosamine, mannose and fucose residues as found in chitobiose (GlcNAc beta 1-4GlcNAc), mannobiose (Man alpha 1-3Man) and lacto-N-fucopentaose II [Fuc alpha 1-4(Gal beta 1-3)GlcNAc beta 1-3Gal beta 1-4Glc] respectively.
Loveless
R W
RW
Section of Glycoconjugate Research, Clinical Research Centre, Harrow, Middx., U.K.
Feizi
T
T
Childs
R A
RA
Mizuochi
T
T
Stoll
M S
MS
Oldroyd
R G
RG
Lachmann
P J
PJ
D000117:Acetylglucosamine / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D002417:Cattle; D037222:Collectins; D003168:Complement Fixation Tests; D004187:Disaccharides; D005643:Fucose / Q000378:metabolism*; D005936:Glucans / Q000378:metabolism; D005944:Glucosamine / Q000031:analogs & derivatives*; D037102:Lectins / Q000378:metabolism*; D008351:Mannans / Q000378:metabolism; D008358:Mannose / Q000378:metabolism*; D009844:Oligosaccharides / Q000378:metabolism; D012441:Saccharomyces cerevisiae; D012712:Serum Globulins / Q000378:metabolism*
D037222:Collectins; D004187:Disaccharides; D005936:Glucans; D037102:Lectins; D008351:Mannans; D009844:Oligosaccharides; D012712:Serum Globulins; C024014:conglutinin; C014647:mannobiose; C041762:lacto-N-fucopentaose II; D005643:Fucose; C032438:chitobiose; D005944:Glucosamine; D008358:Mannose; D000117:Acetylglucosamine