Comparative antimutagenicity of 5 compounds against 5 mutagenic complex mixtures in Salmonella typhimurium strain TA98.
Using the Ames Salmonella/microsome assay, we compared the antimutagenic activities of chlorophyllin, retinol, beta-carotene, vitamin C, and vitamin E against solvent extracts of coal dust, diesel emission particles, airborne particles, fried beef, and tobacco snuff. The results show that chlorophyllin inhibited 69% of the mutagenic activity of tobacco snuff and over 90% of that of the other 4 complex mixtures. Retinol inhibited 29-48% of the mutagenic activity of all 5 complex mixtures. beta-Carotene, vitamin C, and vitamin E inhibited, if any, less than 39% of the activity of the complex mixtures studied. Vitamin C enhanced the mutagenicity of airborne particles. These results indicate that for these dietary and environmental complex mixtures chlorophyllin is a more effective antimutagen than retinol, beta-carotene, vitamin C, and vitamin E.
Ong
T
T
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888.
Whong
W Z
WZ
Stewart
J D
JD
Brockman
H E
HE
D000388:Air; D001205:Ascorbic Acid / Q000494:pharmacology*; D002338:Carotenoids / Q000494:pharmacology*; D002734:Chlorophyll / Q000031:analogs & derivatives*; D002735:Chlorophyllides / Q000494:pharmacology*; D003031:Coal; D004391:Dust; D005648:Fuel Oils; D008460:Meat; D009152:Mutagenicity Tests; D009153:Mutagens / Q000302:isolation & purification / Q000494:pharmacology*; D010947:Plants, Toxic; D012486:Salmonella typhimurium / Q000187:drug effects*; D014026:Nicotiana; D014801:Vitamin A / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*; D019207:beta Carotene
D002735:Chlorophyllides; D003031:Coal; D004391:Dust; D005648:Fuel Oils; D009153:Mutagens; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; D002734:Chlorophyll; D002338:Carotenoids; C007020:chlorophyllin; D001205:Ascorbic Acid