Unilateral topical cortical application of penicillin: electrographic aspects. A new complement to an old model.
In 7 cats 800 IU of penicillin were applied diffusely over one hemisphere on the exposed neocortex. After 40 min all animals showed bilateral and synchronous burst discharges with a higher amplitude at the hemisphere where the penicillin had been applied. These data fill a gap in the literature concerning feline generalized penicillin epilepsy, in which penicillin is applied bilaterally on the exposed neocortex.
Cukiert
A
A
Laboratory of Functional Neurosurgery, University of São Paulo, School of Medicine, Brazil.
Baumel
S W
SW
Andrioli
M S
MS
Marino
R
R
D000287:Administration, Topical; D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D004195:Disease Models, Animal; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D010406:Penicillins / Q000008:administration & dosage*
D010406:Penicillins