title: Radical curative activity of a new 8-aminoquinoline derivative (CDRI 80/53) against Plasmodium cynomolgi B in monkeys.
abstract: An analogue of primaquine, N1-(3-acetyl-4-5-dihydro-2-furanyl)-N4-(6-methoxy-8-quinolinyl) 1,4-pentanediamine, CDRI Code 80/53), has been evaluated for anti-relapse activity against sporozoite induced Plasmodium cynomolgi B infection in rhesus monkeys. The compound has shown 100% curative anti-relapse activity at 1.25 mg/kg x 7 day dose schedule, thereby giving a primaquine index of 0.8. The compound is currently under Phase-I clinical trials.
authors.affiliation: Division of Microbiology and Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: G P
authors.initials: GP
authors.lastname: Dutta
authors.forename: S K
authors.initials: SK
authors.lastname: Puri
authors.forename: A P
authors.initials: AP
authors.lastname: Bhaduri
authors.forename: M
authors.initials: M
authors.lastname: Seth
mesh_terms: D000634:Aminoquinolines / Q000627:therapeutic use*; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D008253:Macaca mulatta; D008288:Malaria / Q000188:drug therapy*; D015394:Molecular Structure; D011319:Primaquine / Q000627:therapeutic use / Q000031:analogs & derivatives
chemical_list: D000634:Aminoquinolines; D000962:Antimalarials; D011319:Primaquine; C063469:bulaquine