title: Differential expression of CD25 and HC2 antigens on subtypes of acute myeloid leukemias.
abstract: The presence of CD25 and HC2 antigens in 66 different patients with acute myeloid leukemia (AML) was investigated. The expression of both antigens was observed in 32% of AML cells. Dual fluorescence staining experiments performed in 5 AML patient cells showed that CD25 and HC2 antigens were simultaneously expressed in a single cell. The expression of both antigens was mainly observed in the M4 and M5 subtypes of AML. Although immunopurified IL-2 was able to block the binding of anti-CD25 monoclonal antibody to the AML cells, the IL-2 receptor did not appear to be functional.
authors.affiliation: Laboratorio de Inmunogenética, Hospital de Clínicas José de San Martín, Facultad de Medicina, Buenos Aires, Argentina.
authors.forename: M R
authors.initials: MR
authors.lastname: Padrós
authors.forename: M C
authors.initials: MC
authors.lastname: Salamone
authors.forename: P A
authors.initials: PA
authors.lastname: Zunszain
authors.forename: L
authors.initials: L
authors.lastname: Fainboim
mesh_terms: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology; D015470:Leukemia, Myeloid, Acute / Q000276:immunology*; D015479:Leukemia, Myelomonocytic, Acute / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D011994:Recombinant Proteins; C060024:hairy cell leukemia antigen, HC2, human