Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. I: The cytochrome P-450 dependent monooxygenase system.
The effects of long-term caloric restriction on the hepatic cytochrome P-450 dependent monooxygenase system were investigated in the 22-month-old Fischer 344 rat. Caloric restriction decreased the age-related changes in hepatic testosterone metabolism, which are associated with demasculinization of the liver. Caloric restriction also increased hepatic microsomal testosterone 6 beta-hydroxylase, lauric acid 12-hydroxylase and 4-nitrophenol hydroxylase activities over corresponding values in both ad libitum fed 22-month and 60-day-old control male rats. This suggests that cytochrome P-450 isozymes, P-450 pcn1&2, P-452 and P450j may be induced by caloric restriction. Such changes in cytochrome P-450 isozyme profiles could result in altered carcinogen activation, radical formation or drug detoxication in the calorically restricted rat.
Leakey
J E
JE
Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079.
Cunny
H C
HC
Bazare
J
J
Webb
P J
PJ
Feuers
R J
RJ
Duffy
P H
PH
Hart
R W
RW
D000375:Aging / Q000378:metabolism*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D002149:Energy Intake; D008658:Inactivation, Metabolic; D007527:Isoenzymes / Q000378:metabolism; D008017:Life Expectancy; D008099:Liver / Q000201:enzymology*; D008297:Male; D010105:Oxygenases / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344
D007527:Isoenzymes; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases