title: Histogenesis of neoformation in the endocrine pancreas of aging horses.
abstract: Pancreatic tissue from 20 horses was examined using immunocytochemical techniques. In aged horses, neogenesis of endocrine cells, neoformation, and hyperplasia of islets occurred closely associated with the pancreatic duct; these changes were regarded as nesidioblastosis. In addition, pancreatic fibrosis accompanied by ductal proliferation and endocrine neogenesis was considered a regenerative change. Thus, the origin of neoformation in the endocrine pancreas was in the ductal system, and it is suggested that the pancreatic endocrine cells were of endodermal origin.
authors.affiliation: Department of Comparative Pathology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Furuoka
authors.forename: T
authors.initials: T
authors.lastname: Shirakawa
authors.forename: H
authors.initials: H
authors.lastname: Taniyama
authors.forename: H
authors.initials: H
authors.lastname: Ohishi
authors.forename: H
authors.initials: H
authors.lastname: Satoh
authors.forename: C
authors.initials: C
authors.lastname: Itakura
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D005260:Female; D005355:Fibrosis; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D006965:Hyperplasia; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000473:pathology*; D008297:Male; D010182:Pancreatic Diseases / Q000473:pathology / Q000662:veterinary*