title: [Preleukemic disorders].
abstract: Certain hematopoietic disorders and immunodeficiency states are known to carry a risk of developing acute nonlymphocytic leukemia. In the past some of them have been classified by a variety of terms ranging from refractory anemia to preleukemia, but are currently grouped into a new concept of the myelodysplastic syndromes (MDS). The purpose of this article is to briefly review the updated knowledge of the MDS with emphasis on the clonal origin, natural history and mechanisms of leukemogenesis.
authors.affiliation: 1st Dept. of Internal Medicine, Faculty of Medicine, Kyoto University.
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshida
authors.forename: S
authors.initials: S
authors.lastname: Oguma
authors.forename: H
authors.initials: H
authors.lastname: Uchino
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000473:pathology / Q000503:physiopathology; D011289:Preleukemia / Q000097:blood / Q000473:pathology / Q000503:physiopathology; D011379:Prognosis