title: Treatment of adjustment disorders: a comparative evaluation.
abstract: With the aim of assessing four forms of therapy with adjustment-disordered outpatients, we randomly assigned 70 subjects to the following treatments: supportive psychotherapy (psychoanalytically oriented), viloxazine (an antidepressant), lormetazepam (a benzodiazepine), and S-adenosylmethionine (a methyl donor with antidepressive properties). A further group of 15 subjects received a placebo, orally administered. The trial lasted 4 wk. None of the treatments had clearly superior effects over others on scores on the Zung Self-rating Depression Scale. All produced a significant improvement. However, groups given S-adenosylmethionine and supportive psychotherapy had the highest mean scores.
authors.forename: D
authors.initials: D
authors.lastname: De Leo
mesh_terms: D000275:Adjustment Disorders / Q000188:drug therapy*; D000284:Administration, Oral; D000328:Adult; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008140:Lorazepam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D009025:Morpholines / Q000627:therapeutic use*; D011575:Psychoanalytic Therapy; D011897:Random Allocation; D012436:S-Adenosylmethionine / Q000627:therapeutic use*; D014745:Viloxazine / Q000627:therapeutic use*
chemical_list: D014151:Anti-Anxiety Agents; D009025:Morpholines; D001569:Benzodiazepines; D014745:Viloxazine; D012436:S-Adenosylmethionine; C023842:lormetazepam; D008140:Lorazepam