title: [A heparin-glucuronylglucosaminoglycan combination for topical use. An evaluation of the therapeutic effects in induced experimental muscle damage and in minor sports injuries].
abstract: The aim of the study was to evaluate the clinical efficacy of the association of heparin and sulodexide on experimental pain and on "small sport traumatology". In the experimental part of the study, cutaneous pain threshold and subcutaneous tissue ticking were measured after the induction of an algogenic focus in deep somatic side. In the clinical part of the study, pain intensity (by A.V. scale), athletic performance and therapy duration, in athletes from muscular or articular posttraumatic injuries, were also assessed. After the therapy with the examined drug, a less significant lowering of cutaneous pain threshold and a less subcutaneous tissue thickening were found in the experimental study; in the clinical study a significant reduction of pain intensity and a quick restore of athletic performance were revealed. These results allow to conclude that the drug in effective to reduce painful symptomatology in both experimental and clinical conditions, by the limitation of some aspects of inflammation.
authors.affiliation: Università degli Studi G. D'Annunzio, Chieti.
authors.forename: L
authors.initials: L
authors.lastname: Dragani
authors.forename: A
authors.initials: A
authors.lastname: Colozzi
authors.forename: C
authors.initials: C
authors.lastname: Schiavone
authors.forename: G
authors.initials: G
authors.lastname: Obletter
authors.forename: V
authors.initials: V
authors.lastname: Celiberti
authors.forename: S
authors.initials: S
authors.lastname: Radico
authors.forename: L
authors.initials: L
authors.lastname: Vecchiet
mesh_terms: D000208:Acute Disease; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001265:Athletic Injuries / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005260:Female; D006025:Glycosaminoglycans / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000293:injuries*; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology
chemical_list: D004338:Drug Combinations; D006025:Glycosaminoglycans; C007858:glucuronyl glucosamine glycan sulfate; D006493:Heparin
vernacular_title: L'associazione eparina-glucoronilglucosaminoglicano per uso topico. Valutazione degli effetti terapeutici nel danno muscolare sperimentale indotto e nella traumatologia minore da sport.