Expression of the ras oncogene in gynecologic tumors.
Control of oncogene expression has been shown to be a coordinated regulatory mechanism in normal growth and development. Overt expression of these genes also has been noted in transformed or neoplastic cell types. The ras family of oncogenes has been shown to be particularly evident among genes expressed in malignant tissues. We provide evidence, using ribonucleic acid dot analysis and Western blot analysis of gynecologic tumor extracts, that ras expression may be a common occurrence in these malignancies. Furthermore, the ras-related peptides can be detected in sera of some patients with tumors.
O'Brien
T J
TJ
Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock 72205.
Bannon
G A
GA
Bard
D S
DS
Hardin
J W
JW
Quirk
J G
JG
D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D011905:Genes, ras; D005833:Genital Neoplasms, Female / Q000235:genetics*; D006801:Humans; D015151:Immunoblotting; D010051:Ovarian Neoplasms / Q000235:genetics; D011233:Precipitin Tests; D011518:Proto-Oncogene Proteins / Q000235:genetics; D016283:Proto-Oncogene Proteins p21(ras); D012333:RNA, Messenger / Q000032:analysis; D014594:Uterine Neoplasms / Q000235:genetics
D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)