title: Interferon alpha induced and maintained complete remission in chronic granulocytic leukemia in relapse after bone marrow transplantation.
abstract: We describe a patient with chronic granulocytic leukaemia (CGL) who relapsed after allogeneic bone marrow transplantation (BMT). Interferon alpha 2b (IFN alpha 2b) induced and maintained a complete remission. IFN alpha 2b led to full restoration of donor bone marrow. This case provides evidence to support a trial of IFN alpha in patients with relapsing CGL after BMT.
authors.affiliation: Department of Haematology, Cliniques Universitaires St-Luc, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Borgies
authors.forename: A
authors.initials: A
authors.lastname: Ferrant
authors.forename: A
authors.initials: A
authors.lastname: Delannoy
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
authors.forename: J L
authors.initials: JL
authors.lastname: Michaux
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D006085:Graft Survival / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007370:Interferon Type I / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D008297:Male; D011994:Recombinant Proteins; D012074:Remission Induction; D014184:Transplantation, Homologous
chemical_list: D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D006918:Hydroxyurea