[The significance of epidermal changes in the early diagnosis and development of mycosis fungoides].
In 47 patients with stage I mycosis fungoides, biopsy of skin has revealed substantial changes in epidermis acanthosis with confluent epidermal processes, focal dystrophy of basal cells, mitoses in various epidermal layers, parakeratotic foci without a granular layer. Histoautoradiographic and immunomorphological studies demonstrated that enhanced proliferative activity of keratinocytes that was more pronounced in stages I and II mycosis fungoides and impaired epidermal differentiation that was predominant in neoplastic stage III underlay the above changes. There was ultrastructural evidence for abnormal epidermal keratinization. It was proposed that epidermal abnormalities made an important contribution to the development of mycosis fungoides.
Persina
I S
IS
Zabanova
E V
EV
Vavilov
A M
AM
Avervakh
E V
EV
D005455:Fluorescent Antibody Technique; D006801:Humans; D009182:Mycosis Fungoides / Q000175:diagnosis* / Q000473:pathology; D009367:Neoplasm Staging; D012867:Skin / Q000473:pathology* / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology
Znachenie izmeneniĭ épidermisa v ranneĭ diagnostike i razvitii gribovidnogo mikoza.