Natural and antibody-dependent cytotoxicity in different clinical stages of human immunodeficiency virus type 1 infection.
Peripheral blood mononuclear cells, PBMC, from 64 HIV-1-infected patients were tested for natural killer (NK) and antibody-dependent cellular cytotoxicity (ADCC) functions against HIV-1-infected U937 clone 2 cells. The ADCC function was tested both with serum and effector cells from the same patient, with an HIV-1 antibody positive serum and with rabbit IgG antibodies against beta 2-microglobulin expressed on the virus-infected target cells. NK and ADCC functions were often found to be suppressed in HIV-1-infected individuals regardless of the severity of HIV-1 infection. The fact that impaired effector cell functions could be detected even in asymptomatic carriers, suggests that profound changes in cellular immunity may be present at an early stage of HIV-1 infection.
Ljunggren
K
K
Department of Immunology, Karolinska Institute, Stockholm, Sweden.
Karlson
A
A
Fenyö
E M
EM
Jondal
M
M
D000386:AIDS-Related Complex / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D015483:HIV Antibodies / Q000276:immunology; D015497:HIV-1; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D001613:beta 2-Microglobulin / Q000032:analysis
D015483:HIV Antibodies; D001613:beta 2-Microglobulin