title: Improvement of immune-complex nephritis associated with hepatitis B surface antigen excess.
abstract: A case of hypocomplementemic membranoproliferative glomerulonephritis was studied during remission of nephrosis induced by high doses of corticosteroids. Hepatitis B surface antigen (HBsAg) and immune complexes were detected in serum and glomeruli. Anti-hepatitis-B surface antibody, undetectable in serum by conventional radioimmunoassays was identified in circulating immune complexes (CIC). On two occasions, improvement in renal function coincided paradoxically with an extreme increase in serum HBsAg levels as well as with marked elevation of CIC. We suggest that, as previously observed in animal models of glomerulonephritis, extreme antigen excess may inhibit glomerular deposition of immune complexes.
authors.affiliation: Department of Medicine, Mount Scopus, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Raz
authors.forename: J
authors.initials: J
authors.lastname: Michaeli
authors.forename: M
authors.initials: M
authors.lastname: Brezis
authors.forename: M M
authors.initials: MM
authors.lastname: Popovtzer
authors.forename: Y
authors.initials: Y
authors.lastname: Gazitt
authors.forename: D
authors.initials: D
authors.lastname: Shouval
mesh_terms: D000936:Antigen-Antibody Complex / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D006509:Hepatitis B / Q000150:complications; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D011863:Radioimmunoassay
chemical_list: D000936:Antigen-Antibody Complex; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D011241:Prednisone; D008775:Methylprednisolone