title: The effect of diphenylhydantoin on the electroretinogram.
abstract: Acute administration of diphenylhydantoin (DPH) in rabbits produces a significant increase in the amplitude of the a-wave. A marked increase in the amplitude of the b-wave is also noted but the time course is slower than that for the a-wave. While in controls the oscillatory potential (OP) recordings essentially consist of three major types, recordings taken after DPH injection consist of one major OP (OP2), which appears to be a result of the fusion of the original OP2 with another OP produced by the DPH injection. A similar blend of OPs was also seen in ERGs recorded from three human subjects on DPH therapy.
authors.affiliation: Department of Ophthalmology, McGill University, Montreal, Quebec, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Lachapelle
authors.forename: L
authors.initials: L
authors.lastname: Blain
authors.forename: M G
authors.initials: MG
authors.lastname: Quigley
authors.forename: R C
authors.initials: RC
authors.lastname: Polomeno
authors.forename: S
authors.initials: S
authors.lastname: Molotchnikoff
mesh_terms: D000293:Adolescent; D000818:Animals; D003623:Dark Adaptation; D004596:Electroretinography / Q000187:drug effects; D006801:Humans; D008297:Male; D009991:Oscillometry; D010672:Phenytoin / Q000494:pharmacology*; D010775:Photic Stimulation; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000502:physiology
chemical_list: D010672:Phenytoin