Antibodies specific for the pancreatic islet amyloid polypeptide associated with type 2 diabetes mellitus.
Antibodies raised to a lysine solubilized peptide composed of residues 20-29 of the pancreatic islet amyloid polypeptide react selectively and specifically with this polypeptide and with islet amyloid deposits in Type 2 diabetes mellitus. These antibodies may prove useful in studies employing radioimmunoassay of body fluids and islet cell cultures in order to define if a pathogenic relationship exists between the islet amyloid polypeptide and Type 2 diabetes mellitus.
Glenner
G G
GG
University of California, San Diego 92093.
Ceja
F
F
Mehlhaff
P
P
D000595:Amino Acid Sequence; D000682:Amyloid / Q000032:analysis* / Q000276:immunology; D000818:Animals; D000918:Antibody Specificity; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000032:analysis*; D008251:Macaca; D008969:Molecular Sequence Data; D010455:Peptides / Q000032:analysis* / Q000276:immunology
D000682:Amyloid; D010455:Peptides