Interleukin-1 inducing activity of a streptococcal preparation OK-432 and its fractions by human monocytes.
Interleukin-1 (IL-1) inducing activity of a streptococcal preparation OK-432 and its fractions by monocytes were investigated in patients with lung cancer and healthy subjects. The results showed that cell free extracts and cell wall fractions of OK-432 were the strong IL-1 inducing fractions. IL-1 activity released by OK-432-stimulated monocytes of patients with lung cancer fell within normal range. OK-432 stimulated intracellular IL-1 synthesis as well as extracellular release by monocytes. These results, therefore, suggested that OK-432 immunotherapy in patients with malignant diseases might be effective by increasing IL-1 production of monocytes.
Katsuta
S
S
3rd Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
Kaneko
Y
Y
Tsutsui
K
K
Tamaki
S
S
Ibata
H
H
Chen
D R
DR
Suzuki
S
S
Natsuume-Sakai
S
S
Yamamoto
A
A
D000368:Aged; D001688:Biological Products / Q000276:immunology*; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000276:immunology; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D009367:Neoplasm Staging; D010844:Picibanil / Q000276:immunology*; D013297:Streptococcus pyogenes / Q000276:immunology*
D001688:Biological Products; D007375:Interleukin-1; D010844:Picibanil