Autoantibody formation after bone marrow transplantation. Comparison between acetylcholine receptor antibodies and other autoantibodies and analysis of HLA and Gm markers.
Clinical myasthenia gravis has been reported in an increased frequency after bone marrow grafting. The number of bone marrow transplanted patients making IgG autoantibodies directed against the autoantigens cardiolipin, SS-B (La) and thyroglobulin was found to be significantly lower as compared to the autoantigen acetylcholine receptor protein. The occurrence of antibodies to single-stranded DNA was found in a lower frequency than acetylcholine receptor antibodies but the difference was not statistically significant. Antibodies to cardiolipin were frequently observed prior to grafting. The G1m1,2 and G3m5 phenotype frequency did not differ in individuals who developed receptor antibodies from that found in the normal population. Analysis of HLA antigens in this patient group revealed no association to HLA B8/DR3 or B35/DR1. This may indicate that the etiology of myasthenia gravis induced by bone marrow grafting differs as compared with the spontaneous form of myasthenia gravis and the penicillamine-induced disease.
Smith
C I
CI
Department of Clinical Immunology, Karolinska Institute, Huddinge Hospital, Sweden.
Norberg
R
R
Möller
G
G
Lönnqvist
B
B
Hammarström
L
L
D000917:Antibody Formation; D001323:Autoantibodies / Q000032:analysis / Q000276:immunology*; D015415:Biomarkers / Q000032:analysis; D016026:Bone Marrow Transplantation; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000032:analysis; D007700:Kinetics; D009157:Myasthenia Gravis / Q000276:immunology; D011950:Receptors, Cholinergic / Q000276:immunology; D012217:Rheumatoid Factor / Q000032:analysis
D001323:Autoantibodies; D015415:Biomarkers; D006680:HLA Antigens; D007129:Immunoglobulin Gm Allotypes; D011950:Receptors, Cholinergic; D012217:Rheumatoid Factor