title: Crystallization and preliminary X-ray analysis of the human c-H-ras-oncogene product p21 complexed with GTP analogues.
abstract: The catalytic domain (amino acid residues 1 to 166) of the human ras-oncogene product p21 complexed with the GTP analogues beta,gamma-imido-GTP (GMPPNP), beta,gamma-methylene-GTP (GMPPCP), and guanosine-5'-(gamma-thiotriphosphate) (GTP gamma S) have been been crystallized. Crystals of the GMPPNP and GMPPCP complexes are well suited for high resolution X-ray crystallography. They belong to space group P3(1)21 (or its enantiomorph P3(2)21) with unit cell axes a=b=40.3 A and c = 162.2 A.
authors.affiliation: Biophysik, Max-Planck-Institut für Medizinische Forschung, Heidelberg, F.R.G.
authors.forename: A
authors.initials: A
authors.lastname: Scherer
authors.forename: J
authors.initials: J
authors.lastname: John
authors.forename: R
authors.initials: R
authors.lastname: Linke
authors.forename: R S
authors.initials: RS
authors.lastname: Goody
authors.forename: A
authors.initials: A
authors.lastname: Wittinghofer
authors.forename: E F
authors.initials: EF
authors.lastname: Pai
authors.forename: K C
authors.initials: KC
authors.lastname: Homes
mesh_terms: D001483:Base Sequence; D003460:Crystallization; D011905:Genes, ras; D006160:Guanosine Triphosphate / Q000031:analogs & derivatives*; D006801:Humans; D046911:Macromolecular Substances; D014961:X-Ray Diffraction
chemical_list: D046911:Macromolecular Substances; D006160:Guanosine Triphosphate