title: Mood elevating effect of fluoxetine in a diagnostically homogeneous inpatient population with major depressive disorder.
abstract: According to severity of depressive symptomatology 14 inpatients with major depressive disorder (RDC) were assigned to 2 groups of 7 patients each with 6 of them receiving fluoxetine 60-80 mg/day and 1 receiving placebo in each group in a double-blind manner. After the treatment period of 35 days clinical improvement as assessed by standardized rating scales was more pronounced in the moderately depressed patients. There were no substantial side-effects in the 2 groups. These findings corroborate previous results from outpatient studies in more heterogeneous patient samples demonstrating safety and antidepressive efficacy of fluoxetine.
authors.affiliation: Department of Psychiatry, University of Freiburg, Federal Republic of Germany.
authors.forename: U
authors.initials: U
authors.lastname: von Bardeleben
authors.forename: F
authors.initials: F
authors.lastname: Holsboer
authors.forename: A
authors.initials: A
authors.lastname: Gerken
authors.forename: O
authors.initials: O
authors.lastname: Benkert
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012895:Sleep, REM / Q000187:drug effects
chemical_list: D005473:Fluoxetine