title: Scleritis as the presenting manifestation of procainamide-induced lupus.
abstract: Scleritis developed in a patient using procainamide as part of a drug-induced lupus syndrome. Systemic findings, which developed after the onset of ocular signs and symptoms, included arthralgias, myalgias, weight loss, and markedly elevated antinuclear antibody (ANA) titers and antihistone titers. The clinical picture and laboratory abnormalities improved after discontinuation of the drug. Although systemic findings secondary to drug-induced lupus have been well described in the medical literature, this case represents the first detailed ophthalmologic documentation of scleritis as the presenting manifestation of procainamide-induced lupus.
authors.affiliation: Eye and Ear Institute of Pittsburgh, Department of Ophthalmology, University of Pittsburgh School of Medicine.
authors.forename: P W
authors.initials: PW
authors.lastname: Turgeon
authors.forename: T L
authors.initials: TL
authors.lastname: Slamovits
mesh_terms: D000368:Aged; D000906:Antibodies / Q000032:analysis; D000974:Antibodies, Antinuclear / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006657:Histones / Q000276:immunology; D006801:Humans; D008177:Lupus Vulgaris / Q000139:chemically induced / Q000175:diagnosis* / Q000276:immunology; D011342:Procainamide / Q000009:adverse effects*; D015423:Scleritis / Q000175:diagnosis*; D013577:Syndrome; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D000906:Antibodies; D000974:Antibodies, Antinuclear; D006657:Histones; D011342:Procainamide