title: Dedifferentiated chondrosarcoma of bone.
abstract: Dedifferentiated chondrosarcoma is a highly malignant variant of chondrosarcoma. Approximately 11% of chondrosarcomas can be expected to dedifferentiate into more anaplastic lesions. Radiographic evidence of a benign-appearing cartilage lesion adjacent to a lytic, highly aggressive lesion suggests dedifferentiation. Despite radical surgical treatment, the prognosis is unfavorable, with a 5 year survival rate of 10%.
authors.affiliation: Department of Orthopedics and the Section of Surgical Pathology, Rochester, Minnesota 55905.
authors.forename: P J
authors.initials: PJ
authors.lastname: Daly
authors.forename: F H
authors.initials: FH
authors.lastname: Sim
authors.forename: L E
authors.initials: LE
authors.lastname: Wold
mesh_terms: D000368:Aged; D000708:Anaplasia / Q000473:pathology; D001859:Bone Neoplasms / Q000473:pathology*; D002813:Chondrosarcoma / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans