title: Effects of furosemide on the oral cavity.
abstract: Furosemide, a potent loop diuretic, has been reported to cause xerostomia, a sensation of oral dryness. We obtained urine and salivary secretions from five normal males after oral intake of either 0.5 mg/kg body weight of furosemide or placebo. The experimental treatment resulted in a five-fold increase in urinary output. In contrast, analysis of salivary secretions indicated there were no significant differences in flow rates, total output, total protein, or Na+, K+, or Cl- concentrations following drug or placebo. Subjectively, xerostomia was experienced 10 times more frequently after ingestion of furosemide. These data suggest that, in vivo, furosemide had a greater effect on the kidney than on the salivary gland and that the sensation of oral dryness is not solely a function of the quantitative salivary output.
authors.forename: J C
authors.initials: JC
authors.lastname: Atkinson
authors.forename: J B
authors.initials: JB
authors.lastname: Shiroky
authors.forename: A
authors.initials: A
authors.lastname: Macynski
authors.forename: P C
authors.initials: PC
authors.lastname: Fox
mesh_terms: D000328:Adult; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D008297:Male; D012463:Saliva / Q000032:analysis; D012472:Salivation / Q000187:drug effects; D014987:Xerostomia / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D005665:Furosemide