title: [Results of cisplatin-based polychemotherapy and analysis of prognostic factors in ovarian cancer. Apropos of 106 cases].
abstract: One hundred and six patients with stage Ic to IV ovarian carcinoma were treated by a protocol consisting of optimal debulking surgery followed by 9 cycles of CHAP chemotherapy. Clinical response was confirmed by a second-look procedure. Sixty-nine patients (65%) responded with 54 histological complete remissions (50.8%). Nineteen patients did not receive any complementary treatment due to a negative reaction, or prolonged neutropenia. Seven patients received maintenance chemotherapy, 10 an abdominal radiotherapy, 22 intraperitoneal chemotherapy and 11 autologous bone marrow transplantation. The 5-year survival rate was 32.5% and disease-free survival rate was 39.7%. Prognostic-factor analysis showed that age, initial staging, residual disease and cytological grading were significant. The authors propose a classification based on the risk of relapse, and different therapeutic indications for improving response rate and patient survival.
authors.affiliation: Service d'oncohématologie, CHU de Hautepierre, Strasbourg, France.
authors.forename: F
authors.initials: F
authors.lastname: Maloisel
authors.forename: P
authors.initials: P
authors.lastname: Dufour
authors.forename: J P
authors.initials: JP
authors.lastname: Bergerat
authors.forename: J P
authors.initials: JP
authors.lastname: Bellocq
authors.forename: B
authors.initials: B
authors.lastname: Duclos
authors.forename: A
authors.initials: A
authors.lastname: Boilletot
authors.forename: R
authors.initials: R
authors.lastname: Herbrecht
authors.forename: P
authors.initials: P
authors.lastname: Dellenbach
authors.forename: R
authors.initials: R
authors.lastname: Renaud
authors.forename: P
authors.initials: P
authors.lastname: Ritter
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D011379:Prognosis
chemical_list: D002945:Cisplatin
vernacular_title: Résultats d'une polychimiothérapie à base de cisplatine et analyse des facteurs pronostiques dans les cancers de l'ovaire. A propos de 106 cas.