Serotonin receptor blocking effect of SCH 23390.
The effect of SCH 23390 administration on the serotonin system-dependent head twitch behavior was studied in the rat. A small dose of SCH 23390 (1.25 micrograms/kg), injected 20 min before the test, decreased the number of quipazine-induced head twitches. Repeated treatment with SCH 23390 (0.5 mg/kg, SC), once a day for 18 days, increased the number of spontaneously occurring and quipazine-induced head twitches. The enhancing effect of repeated administration of SCH 23390 was blocked by cyproheptadine (0.4 mg/kg). The results indicate that acute injection of SCH 23390 blocks central serotonin receptors, whereas repeated treatment induces their functional supersensitivity.
Bijak
M
M
Polish Academy of Sciences, Institute of Pharmacology, Kraków.
Smiałowski
A
A
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D008297:Male; D011814:Quipazine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects*
D001552:Benzazepines; D011985:Receptors, Serotonin; D011814:Quipazine