Exposure of rats and hamsters to sidestream smoke from cigarettes in a subchronic inhalation study.
A 90-day feasibility study was performed in which rats and hamsters were exposed to the sidestream smoke of cigarettes. The only histopathological changes observed were hyperplasia and metaplasia of the epithelium covering the dorsal nasal turbinate bones in rats. These effects were reversible within 90 days.
von Meyerinck
L
L
Forschungsgesellschaft Rauchen und Gesundheit mbH, Hamburg, FRG.
Scherer
G
G
Adlkofer
F
F
Wenzel-Hartung
R
R
Brune
H
H
Thomas
C
C
D000280:Administration, Inhalation; D000818:Animals; D006224:Cricetinae; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D008679:Metaplasia / Q000139:chemically induced / Q000473:pathology; D010947:Plants, Toxic; D051381:Rats; D012906:Smoke / Q000009:adverse effects*; D014026:Nicotiana; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
D012906:Smoke; D014028:Tobacco Smoke Pollution