[The comparative effect of serotonin agonists on the presynaptic and somatodendritic autoreceptors of serotoninergic neurons].
Experimenting on the slices of cortex and dorsal raphe nucleus of midbrain of rats which were incubated with 3H-hydroxytrypta-mine (3H-HT) studies showed the influence of series of serotonin agonists on the spontaneous and electrically stimulated release of 3H-HT from the slices. It was established that the serotonin in concentration of 10(-5) mol/l similarly inhibits the release of 3H-HT from the electrically stimulated slices of the brain cortex (78.6%) and on slices of the dorsal raphe nucleus of the midbrain (81.6%) had no effect on the spontaneous release of serotonin. The serotonin agonists in order of increasing ability to inhibit the electrically stimulated release of 3H-HT from the cortex slices is as follows: ipsapirone (0%), 8-OH-DPAT (23%), kampirone (26.5%), 1.2-PP (28.6%), kaplapirone (35.7%), buspirone (48%) and TFMPP (67%). On the ability to influence the release of 3H-HT from the electrically stimulated slices of the dorsal raphe nucleus of the midbrain of the rats serotonin agonists were in the following order: TEMPP (12.3%), kampirone (40%), 1.2-PP (42.9%), ipsapirone (52%), 8-OH-DPAT (54.1%), kampirone (57.2%) and buspirone (65.3%). It is suggested that the effect of both ipsapirone, kampirone and 8-OH-DPAT is greatly localized on the somato-dendritic synapses P1A-HT receptors, TEMPP is more on the terminal axons of HT-ergic neurones while kampirone, buspirone and active metabolite 1.2-PP act on the presynaptic and somatodendritic autoreceptors of serotonin.
Dolzhenko
A T
AT
Komissarov
I V
IV
Kharin
N A
NA
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D003712:Dendrites / Q000187:drug effects* / Q000502:physiology; D004558:Electric Stimulation; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011903:Raphe Nuclei / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors
D011985:Receptors, Serotonin; D012701:Serotonin
Sravnitel'noe vliianie agonistov serotonina na presinapticheskie i somatodendritnye autoretseptory serotoninergicheskikh neĭronov.