title: First interim progress report on the second British Institute of Radiology Fractionation Study: short versus long overall treatment times for radiotherapy of carcinoma of the laryngopharynx.
abstract: Preliminary data from a second British Institute of Radiology Fractionation Trial comparing short (less than or equal to 4 weeks) and long (greater than 4 weeks) overall treatment times are reported. The intake of patients ran from January, 1975 to December, 1985 when 611 patients with carcinoma of the laryngo-pharynx were registered in this prospective, randomized, multicentre clinical trial. No significant differences have, so far, been demonstrated between the two arms of the trial with respect to observed survival rates, tumour-free or laryngectomy-free rates. Further long-term follow-up is continuing.
authors.affiliation: British Institute of Radiology, London.
authors.forename: G
authors.initials: G
authors.lastname: Wiernik
authors.forename: C J
authors.initials: CJ
authors.lastname: Alcock
authors.forename: T D
authors.initials: TD
authors.lastname: Bates
authors.forename: R J
authors.initials: RJ
authors.lastname: Berry
authors.forename: J M
authors.initials: JM
authors.lastname: Brindle
authors.forename: J E
authors.initials: JE
authors.lastname: Dalby
authors.forename: J F
authors.initials: JF
authors.lastname: Fowler
authors.forename: W R
authors.initials: WR
authors.lastname: Gajek
authors.forename: S
authors.initials: S
authors.lastname: Goodman
authors.forename: J L
authors.initials: JL
authors.lastname: Haybittle
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D015337:Multicenter Studies as Topic; D010610:Pharyngeal Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D013997:Time Factors