title: [Analgosedation with midazolam and fentanyl as an alternative to general anesthesia in transvaginal follicle puncture within the scope of in vitro fertilization].
abstract: The technique of in vitro fertilization (IVF) was simplified by the development of ultrasound-supported transvaginal follicular centesis. This makes it possible to dispense with general anesthesia. As an alternative, an intravenous analgosedation with midazolam (0.1 mg/kg) and fentanyl (2 micrograms/kg) is presented. Besides a good analgesic and anxiolytic action, an incipient respiratory depression was observed, so that insufflation of oxygen-enriched air is to be recommended. The operation is felt to be comfortable by almost all patients. A high degree of anterograde amnesia is attained. Meticulous intraoperative and postoperative anesthesiological monitoring is a prerequisite for application of this procedure.
authors.affiliation: Institut für Anästhesiologie, Ludwig-Maximilians-Universität, München.
authors.forename: T
authors.initials: T
authors.lastname: Bein
authors.forename: C E
authors.initials: CE
authors.lastname: Klapproth
mesh_terms: D000328:Adult; D000698:Analgesia / Q000379:methods*; D000768:Anesthesia, General; D001143:Arousal / Q000187:drug effects; D002986:Clinical Trials as Topic; D005260:Female; D005283:Fentanyl; D005307:Fertilization in Vitro; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D011939:Mental Recall / Q000187:drug effects; D008874:Midazolam; D010147:Pain Measurement; D011446:Prospective Studies; D011897:Random Allocation; D012119:Respiration / Q000187:drug effects
chemical_list: D008874:Midazolam; D005283:Fentanyl
vernacular_title: Analgosedierung mit Midazolam und Fentanyl als Alternative zur Allgemeinnarkose bei transvaginaler Follikelpunktion im Rahmen der In-vitro-Fertilisation.