Potentiation of cyclophosphamide-induced enhancement of experimental metastasis by splenectomy.
Role of spleen in CY-induced enhancement of experimental lung metastases of Lewis Lung Carcinoma LL2 cells was studied. Reconstitution with spleen cells abolished the enhancing effect of CY. Conversely, removal of spleen in CY treated mice caused about two-fold increase in the number of metastases. In addition in splenectomized mice, the effect of CY was augmented.
Strzadała
L
L
Laboratory of Tumor Immunology, Institute of Immunology and Experimental Therapy, Wroclaw.
Rak
J
J
Zioło
E
E
Kuśnierczyk
H
H
Radzikowski
C
C
D000818:Animals; D002277:Carcinoma / Q000556:secondary*; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary*; D051379:Mice; D008815:Mice, Inbred Strains; D009362:Neoplasm Metastasis; D013154:Spleen / Q000503:physiopathology*
D003520:Cyclophosphamide