title: Chromosome segregation from cell hybrids. VI. Centromeres of both parental chromosome sets stain with antikinetochore antibody.
abstract: Antikinetochore antibodies obtained from serum of patients with the CREST syndrome of scleroderma were used to test the hypothesis that there are differences in protein binding to retained- and segregant-set centromeres in Chinese hamster--human hybrids. This hypothesis is not supported since identical staining of the two types of kinetochores was observed with CREST antibody.
authors.affiliation: Department of Genetics and Human Variation, La Trobe University, Bundoora, Australia.
authors.forename: P A
authors.initials: PA
authors.lastname: Zelesco
authors.forename: J A
authors.initials: JA
authors.lastname: Graves
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D002460:Cell Line; D002503:Centromere / Q000648:ultrastructure*; D002875:Chromosomes / Q000648:ultrastructure*; D006224:Cricetinae; D005455:Fluorescent Antibody Technique; D006801:Humans; D006822:Hybrid Cells / Q000648:ultrastructure*; D008938:Mitosis; D012595:Scleroderma, Systemic / Q000276:immunology
chemical_list: D001323:Autoantibodies