title: The use of bone marrow cells grown in long-term culture for autologous bone marrow transplantation in acute myeloid leukaemia: an update.
abstract: Eleven patients with acute myeloid leukaemia have been transplanted with autologous marrow grown in long-term bone marrow culture. In the high risk group (six patients who had all previously relapsed) the procedure induced a remission in two patients who were in florid relapse at the time of the transplant. Five patients were transplanted in first remission and they remain well and disease-free between 150 and 12 weeks after their autologous transplant.
authors.affiliation: Department of Experimental Haematology, Paterson Institute, Christie Hospital, Manchester, UK.
authors.forename: J
authors.initials: J
authors.lastname: Chang
authors.forename: G R
authors.initials: GR
authors.lastname: Morgenstern
authors.forename: L H
authors.initials: LH
authors.lastname: Coutinho
authors.forename: J H
authors.initials: JH
authors.lastname: Scarffe
authors.forename: T
authors.initials: T
authors.lastname: Carr
authors.forename: D P
authors.initials: DP
authors.lastname: Deakin
authors.forename: N G
authors.initials: NG
authors.lastname: Testa
authors.forename: T M
authors.initials: TM
authors.lastname: Dexter
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002478:Cells, Cultured; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D010865:Pilot Projects; D012074:Remission Induction; D012306:Risk; D013866:Thioguanine / Q000008:administration & dosage; D014182:Transplantation, Autologous
chemical_list: D003561:Cytarabine; D013866:Thioguanine; D003630:Daunorubicin