Clinical efficacy and tolerance of bacampicillin and amoxycillin suspensions in children with acute otitis media.
A total of 97 children with acute otitis media were entered into a single-blind, parallel-group study to compare the efficacy and tolerance of suspensions of bacampicillin, given twice daily, with amoxycillin, given three times daily. The daily dosage was about 40 mg/kg body weight in each case and the duration of treatment was 10 days. Patients were examined before the start of treatment, at an early follow-up visit within 2-3 weeks after the start of treatment and at a late follow-up visit 4-6 weeks after the start of treatment. The initial bacteriology revealed a relatively high proportion of Branhamella catarrhalis and a low incidence of pneumococci. In total, 92 patients were evaluated for efficacy at early follow-up, where both bacampicillin and amoxycillin showed equal and good treatment results in approximately 90% of cases. Evaluation at the last valid visit showed that 80-90% of the patients were either cured or improved. The failure frequency tended to be somewhat higher with amoxycillin.
Puhakka
H J
HJ
Department of Otolaryngology, University Central Hospital, Turku, Finland.
Haapaniemi
J
J
Tuohimaa
P
P
Bondesson
G
G
D000208:Acute Disease; D000658:Amoxicillin / Q000627:therapeutic use*; D000667:Ampicillin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001419:Bacteria / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010033:Otitis Media / Q000188:drug therapy*
D000667:Ampicillin; D000658:Amoxicillin; C011674:bacampicillin