title: Clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs in the cerebrospinal fluid.
abstract: The pharmacokinetics of nonsteroidal anti-inflammatory drugs (NSAIDs) in the cerebrospinal fluid (CSF) is of clinical interest as it may be related to some of their properties and side-effects. Two types of NSAIDs can be described with respect to their concentration and time course in CSF: in the first type, the transfer across the blood-brain barrier seems to be controlled by simple physico-chemical factors. These drugs (oxyphenbutazone, indomethacin, ketoprofen) are characterized by a high lipophilicity. At steady state, their free plasma concentrations correspond to their CSF concentrations. The second group consists of more hydrophilic compounds (salicylates); there is no correlation between plasma concentrations and CSF concentration. Further investigation needs to be carried out on CNS side-effects and the antialgesic activity of salicylates in relation on their CSF distribution.
authors.affiliation: Département de Pharmacologie, URA CNRS 1288, Faculté de Médecine de Nancy, France.
authors.forename: B
authors.initials: B
authors.lastname: Bannwarth
authors.forename: P
authors.initials: P
authors.lastname: Netter
authors.forename: J
authors.initials: J
authors.lastname: Pourel
authors.forename: R J
authors.initials: RJ
authors.lastname: Royer
authors.forename: A
authors.initials: A
authors.lastname: Gaucher
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics; D006801:Humans
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal