title: [Cyanocobalamin Reference Standard (Control 871) of National Institute of Hygienic Sciences].
abstract: Cyanocobalamin was tested for the preparation of "Cyanocobalamin Reference Standard (Control 871)". Analytical data obtained were as follows: loss on drying, 11.6%; infrared spectrum, same as that of Cyanocobalamin Reference Standard (Control 861); thin-layer chromatography, two contaminants were detected; high-performance liquid chromatography, seven contaminants were detected; assay, 99.9% by JP XI method and 100.2% by HPLC method in terms of J.P. Reference Standard (Control 861), respectively. On the basis of those results, this material was authorized as the Japanese Pharmacopoeia Standard (Control 871).
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: R
authors.initials: R
authors.lastname: Hiroshige
authors.forename: M
authors.initials: M
authors.lastname: Murai
authors.forename: H
authors.initials: H
authors.lastname: Tokunaga
authors.forename: S
authors.initials: S
authors.lastname: Okada
authors.forename: T
authors.initials: T
authors.lastname: Kimura
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004340:Drug Contamination; D007564:Japan; D010602:Pharmacopoeias as Topic / Q000592:standards*; D012015:Reference Standards; D013055:Spectrophotometry, Infrared; D014805:Vitamin B 12 / Q000032:analysis / Q000592:standards*
chemical_list: D014805:Vitamin B 12