Ontogenic development of the elastic component of the aortic wall in spontaneously hypertensive rats.
In the neonatal stage of development in spontaneously hypertensive rats (SHR), previous studies have shown that arterial pressure is already significantly increased over that of normotensive WKY controls and that other hypertensive characteristics of the cardiovascular system are also in evidence. The present study describes early development of the elastic component of the aortic wall in fetal (days 17, 19, 21-22 of gestation) and neonatal (days 1, 7, 14, 21 of age) SHR and WKY, to determine whether the early pattern of elastin accumulation differs significantly in hypertensive and normotensive animals. The data indicate that in SHR there is a greater concentration of elastin in the aortic wall, a larger cross-sectional area and an increase in the number of lamellar units, both pre- and postnatally. We conclude that the differences in arterial wall structure which are associated with genetic hypertension are established early in development.
Iredale
R B
RB
Dept. of Human Physiology, University of California, Davis 95616.
Eccleston-Joyner
C A
CA
Rucker
R B
RB
Gray
S D
SD
D000818:Animals; D001011:Aorta / Q000196:embryology / Q000254:growth & development* / Q000503:physiopathology; D004549:Elastin / Q000032:analysis* / Q000502:physiology; D006652:Histological Techniques; D006973:Hypertension / Q000503:physiopathology*; D066298:In Vitro Techniques; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D004549:Elastin