Efficacy and tolerance of nifedipine retard vs acebutolol in patients with essential hypertension treated for 26 weeks.
Patients with essential hypertension were given calcium channel antagonist, Nifedipine Retard or Acebutolol for 26 weeks in a single blind, randomised trial. Both drugs reduced mean systolic and diastolic blood pressure, but side effects were less frequent and caused less drop-outs in Nifedipine than in Acebutolol group of patients. We conclude that both Nifedipine Retard and Acebutolol were equally effective in essential hypertension but side effects were considerably milder in patients treated with Nifedipine Retard.
Chamiec
T
T
Zaleska
T
T
Kłoś
J
J
Pietrzykowska
H
H
Bednarz
B
B
Ceremuzyński
L
L
D000070:Acebutolol / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003692:Delayed-Action Preparations; D004341:Drug Evaluation; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects / Q000627:therapeutic use*; D010349:Patient Compliance; D011897:Random Allocation
D003692:Delayed-Action Preparations; D000070:Acebutolol; D009543:Nifedipine