[Renal agenesis and the Fraser syndrome: 4 observations].
The authors report on 4 cases of Fraser syndrome in 2 Turkish families. Both families are consanguinous. In 3 cases there is a bilateral renal agenesis, a feature which is not usually regarded as a main one. Actually the survey of the literature reveals that renal anomalies are not infrequent in this syndrome, even though the cryptophtalmos would be lacking. A five year study of the malformations Registry of the Rhone-Alpes-Auvergne-Jura area shows that the association between renal agenesis and syndactyly (with or without the eye abnormalities) is quite rare. Such an association leads to the diagnosis of Fraser Syndrome even when cryptophtalmos is absent, and requires to look for minor ENT or ophthalmic symptoms by a careful post mortem examination.
Vanlieferinghen
P
P
Pédiatrie et Génétique B, Hôtel-Dieu, CHRU Clermont-Ferrand.
Francannet
C
C
Robert
E
E
Malpuech
G
G
Robert
J M
JM
D000015:Abnormalities, Multiple / Q000235:genetics; D003241:Consanguinity; D005124:Eye Abnormalities / Q000235:genetics*; D005145:Face / Q000002:abnormalities; D005260:Female; D005385:Fingers / Q000002:abnormalities; D006801:Humans; D007668:Kidney / Q000002:abnormalities*; D008297:Male; D013577:Syndrome
Agénésie rénale et syndrome de fraser à propos de 4 observations.