[The systemic environment and dental development. From the clinical to the molecular approach].
Clinical observation of patients with disordered phosphocalcium metabolism has demonstrated that dyschromia and/or dental dysplasias systematically accompany such disorders. A certain action of this steroid on dental buds has been demonstrated after analysis of the effects of experimental vitamin D deficiency in the rat: vitamin D would seem to control the behaviour of cells undergoing differentiation and also after this process is complete. Dentinogenesis and amelogenesis would appear principally to be affected. Two proteins, calbindins D-9K and -28K, may constitute the molecular mediators of this ameloblastic regulation.
Berdal
A
A
Unité 120 INSERM, Le Vésinet.
Cuisinier-Gleizes
P
P
Balmain
N
N
Thomasset
M
M
Brehier
A
A
Deffez
J P
JP
Mathieu
H
H
D000818:Animals; D064026:Calbindins; D002128:Calcium Metabolism Disorders / Q000150:complications*; D006801:Humans; D009805:Odontogenesis; D010760:Phosphorus Metabolism Disorders / Q000150:complications*; D051381:Rats; D064030:S100 Calcium Binding Protein G / Q000502:physiology; D014071:Tooth Abnormalities / Q000209:etiology*; D014807:Vitamin D / Q000502:physiology
D064026:Calbindins; D064030:S100 Calcium Binding Protein G; D014807:Vitamin D
Environnement systémique et développement dentaire. De la clinique à l'approche moléculaire.