title: The femoral head in osteonecrosis. A quantitative study of osteocyte population.
abstract: The occurrence of osteonecrosis following renal transplantation is well recognised but its pathogenesis remains unknown. We have quantified the number of empty osteocytic lacunae in the subchondral bone of femoral heads from a control group of patients, and compared these with femoral heads from a group of renal transplant recipients without evidence of overt osteonecrosis. There is a significant increase in empty osteocytic lacunae in renal transplant patients. We conclude that loss of osteocytes precedes other manifestations of osteonecrosis.
authors.affiliation: Department of Morbid Anatomy, King's College Hospital, London, England.
authors.forename: S
authors.initials: S
authors.lastname: Humphreys
authors.forename: J D
authors.initials: JD
authors.lastname: Spencer
authors.forename: J R
authors.initials: JR
authors.lastname: Tighe
authors.forename: R R
authors.initials: RR
authors.lastname: Cumming
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000328:Adult; D002452:Cell Count; D005260:Female; D005271:Femur Head Necrosis / Q000139:chemically induced / Q000473:pathology*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010011:Osteocytes / Q000473:pathology*; D011183:Postoperative Complications; D014184:Transplantation, Homologous
chemical_list: D000305:Adrenal Cortex Hormones