title: Randomized comparison of oral terbutaline and ritodrine for preventing recurrent preterm labor.
abstract: We compared oral ritodrine and terbutaline for the prevention of recurrent preterm labor. Women between 20 and 35 weeks' gestation who successfully completed a course of intravenous tocolysis were eligible for inclusion. One hundred two patients were randomized to oral ritodrine (20 mg every four hours) or oral terbutaline (5 mg every four hours). The groups showed no significant differences with respect to recognized risk factors for preterm labor or prognostic factors for the failure of tocolysis. Initial treatment failures occurred more frequently in the ritodrine group (nine vs. two, P = .0527). There were no statistically significant differences in the treatment results or frequency of side effects. We conclude that ritodrine appears to be less effective than terbutaline upon the initiation of oral therapy and that oral ritodrine and terbutaline are equivalent in safety and efficacy when used on a long-term basis for preventing recurrent preterm labor.
authors.affiliation: Department of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, Washington.
authors.forename: J N
authors.initials: JN
authors.lastname: Kopelman
authors.forename: P
authors.initials: P
authors.lastname: Duff
authors.forename: J A
authors.initials: JA
authors.lastname: Read
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D011446:Prospective Studies; D011897:Random Allocation; D012008:Recurrence; D012312:Ritodrine / Q000008:administration & dosage* / Q000009:adverse effects; D013726:Terbutaline / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D012312:Ritodrine; D013726:Terbutaline