Intracerebroventricular administration of insulin attenuates retrieval of a passive avoidance response in rats.
The effect of intracerebroventricularly applied insulin on one-trial learning passive avoidance behaviour has been studied in rats. Treatment with 10.3 pmole insulin 1 hr before the 24 hr retention test attenuated passive avoidance behaviour at both the 24 hr and 48 hr retention trials. The data suggest that insulin may play a role in processes relating to the retrieval of information stored in the brain.
Schwarzberg
H
H
Institute of Physiology, Medical Academy Magdeburg, German Democratic Republic.
Bernstein
H G
HG
Reiser
M
M
Günther
O
O
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D007276:Injections, Intraventricular; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D007328:Insulin