[Clinical relevance of calcium antagonists in the treatment of epilepsy].
The antiepileptic effects of dihydropyridine derivates and flunarizine are currently evaluated in controlled clinical trials following earlier reports of their antiepileptic action in experimental animal models of epilepsy and promising pilot studies in human epilepsy. Other calcium antagonists such as verapamil or diltiazem have proved less effective in experimental models. They penetrate poorly into the CNS (Verapamil) and are difficult to evaluate clinically due to relevant pharmacokinetic interactions with antiepileptic drugs.
Schmidt
D
D
Neurologische Klinik der Ludwig-Maximilians-Universität, München.
Ried
S
S
D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans
D002121:Calcium Channel Blockers
Klinische Relevanz von Calcium-Antagonisten in der Behandlung von Epilepsien.