Pharmacokinetic and pharmacodynamic principles of drug therapy in old age. Part 1.
Changes in pharmacokinetics and pharmacodynamics which occur with aging are reviewed. In Part 1, age-related alterations in pharmacokinetics, which deals with absorption, distribution, metabolism and elimination of drugs, are summarized. Special emphasis is placed on "drug clearance" which conceptual importance for the evaluation of drug elimination has only been recently recognized. Age-related physiological alterations and their influence on major determinants for each organ clearance are discussed.
Tsujimoto
G
G
Department of Pharmacology, Yamanashi Medical College, Japan.
Hashimoto
K
K
Hoffman
B B
BB
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D004358:Drug Therapy; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D010599:Pharmacokinetics; D014018:Tissue Distribution