Yeast mer1 mutants display reduced levels of meiotic recombination.
Mutations at the MER1 locus were identified in a search for meiotic mutants defective in chromosome segregation. mer1 strains show decreased levels of inter- and intrachromosomal meiotic recombination and produce inviable spores. The MER1 gene was cloned by complementation of the spore inviability phenotype. Strains carrying disruptions of the MER1 gene are mitotically viable. The epistatic relationships between MER1 and previously characterized meiotic genes are described.
Engebrecht
J
J
Department of Biology, Yale University, New Haven, Connecticut 06511.
Roeder
G S
GS
D001483:Base Sequence; D003001:Cloning, Molecular; D005800:Genes, Fungal; D005822:Genetic Vectors; D008540:Meiosis; D009154:Mutation; D010641:Phenotype; D010957:Plasmids; D011995:Recombination, Genetic; D015183:Restriction Mapping; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000302:isolation & purification; D013172:Spores, Fungal