The topical administration of steroids in the treatment of typical vulvar dystrophies.
Sixty-eight patients with histologically diagnosed typical vulvar dystrophies were treated with local administration of steroids. Twenty-three patients with hyperplastic dystrophies received topical fluorinated corticosteroids twice a day for 4 weeks and once a day for another 2 weeks. Thirty-five patients with lichen sclerosus were given local 2% testosterone propionate in vaseline twice a day for 8 weeks, once a day for another 8 weeks and then 3 times a week for another 8 weeks. Ten patients with mixed dystrophy first received topical fluorinated corticosteroids twice a day for 4 weeks and once a day for another 2 weeks, and then local 2% testosterone propionate in vaseline twice a day for 4 weeks and once a day for another 4 weeks. A relief of symptomatology and a regression of gross appearance were obtained in 82.6% and 69.6% of patients respectively with hyperplastic dystrophy, in 82.9% and 65.7% of those with lichen sclerosus and in 80% and 40% of those with mixed dystrophy. A recurrence of symptomatology often occurred at various times after the end of therapy.
Gadducci
A
A
Department of Obstetrics and Gynecology, University of Pisa, Italy.
Facchini
V
V
Del Bravo
B
B
Dell'Arciprete
T
T
Madrigali
A
A
Fioretti
P
P
D000287:Administration, Topical; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D012008:Recurrence; D013259:Steroids, Fluorinated / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D013739:Testosterone / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D014845:Vulvar Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
D013259:Steroids, Fluorinated; D013739:Testosterone