title: Mumps vaccine L-Zagreb, prepared in chick fibroblasts. I. Production and field trials.
abstract: Leningrad-L3 Mumps Vaccine virus has been further attenuated by adaptation and passage on SPF chick embryo fibroblast cell cultures. This new mumps strain has been designated L-Zagreb and has been used to prepare mumps vaccines which meet the WHO requirements. Observations during both the field trial period prior to registration and during the later use of the vaccine showed that the few reactions observed were mild and that seroconversion was obtained in 88-98% of vaccines. The morbidity of mumps in Croatia declined more than tenfold after the introduction of the new vaccine. During a mumps epidemic, vaccine efficiency was calculated to be 97-100%.
authors.affiliation: Institute of Immunology, Zagreb, Yugoslavia.
authors.forename: M
authors.initials: M
authors.lastname: Beck
authors.forename: R
authors.initials: R
authors.lastname: Welsz-Malecek
authors.forename: M
authors.initials: M
authors.lastname: Mesko-Prejac
authors.forename: V
authors.initials: V
authors.lastname: Radman
authors.forename: M
authors.initials: M
authors.lastname: Juzbasic
authors.forename: M
authors.initials: M
authors.lastname: Rajninger-Miholic
authors.forename: M
authors.initials: M
authors.lastname: Prislin-Musklic
authors.forename: V
authors.initials: V
authors.lastname: Dobrovsak-Sourek
authors.forename: S
authors.initials: S
authors.lastname: Smerdel
authors.forename: D W
authors.initials: DW
authors.lastname: Stainer
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002478:Cells, Cultured; D002642:Chick Embryo; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004338:Drug Combinations / Q000627:therapeutic use; D005347:Fibroblasts; D006801:Humans; D008458:Measles Vaccine / Q000627:therapeutic use; D022542:Measles-Mumps-Rubella Vaccine; D009107:Mumps / Q000517:prevention & control; D009108:Mumps Vaccine / Q000302:isolation & purification* / Q000592:standards / Q000627:therapeutic use; D012411:Rubella Vaccine / Q000627:therapeutic use; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000302:isolation & purification / Q000592:standards; D014944:World Health Organization
chemical_list: D000914:Antibodies, Viral; D004338:Drug Combinations; D008458:Measles Vaccine; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine; D012411:Rubella Vaccine; D014613:Vaccines, Attenuated