title: Reconstructive surgery for immunosuppressed organ-transplant recipients.
abstract: Prolonged vascularized organ allograft survival and an improved quality of life are now possible for many transplant recipients. These advances are due largely to greater understanding of the immune response, the development of potent immunosuppressive agents (cyclosporin A), and improved surgical techniques. Thus more of these patients may require surgical procedures related or unrelated to their original operation, and the plastic surgeon, among other specialists, should be aware of the special problems of the immunocompromised transplant recipient who needs to undergo reconstructive surgery. We report our experience with 15 kidney, heart, and liver transplant recipients who required reconstructive surgery for a variety of conditions. The combined team approach by reconstructive and transplant surgeons is described, as well as the perioperative drug protocol and the special problems that immunosuppressed transplant recipients present. We conclude that these patients can successfully undergo major reconstructive procedures as long as the plastic surgeon not only performs technically flawless surgery, but also familiarizes himself or herself with the special problems of the immunosuppressed host, including the ever-present risk of sepsis and delayed and impaired wound healing, the potential for acute Addisonian crisis, and the possibility of multiple complicating comorbid conditions.
authors.affiliation: Division of Plastic and Reconstructive Surgery, University of Illinois, Chicago.
authors.forename: M
authors.initials: M
authors.lastname: Cohen
authors.forename: R
authors.initials: R
authors.lastname: Pollak
authors.forename: J
authors.initials: J
authors.lastname: Garcia
authors.forename: M F
authors.initials: MF
authors.lastname: Mozes
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016027:Heart Transplantation; D006801:Humans; D007108:Immune Tolerance; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation; D016031:Liver Transplantation; D011292:Premedication; D012307:Risk Factors; D013518:Surgery, Plastic; D013530:Surgical Wound Infection / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents