Unique aspects of quinolone pharmacokinetics.
Despite some limited differences in pharmacokinetic parameters among the newer quinolones, their pharmacology is characterised by high volumes of distribution, long elimination half-lives, good to excellent bioavailability, low protein binding, limited biotransformation and different elimination pathways (mainly through the kidneys). The unique aspects of quinolones in comparison with beta-lactams and aminoglycosides are their higher volumes of distribution, longer elimination half-lives and their intracellular high concentration, especially in phagocytic cells.
Lode
H
H
Medical Department of Klinikum Steglitz, Freie Universität, Berlin, Federal Republic of Germany.
Höffken
G
G
Borner
K
K
Koeppe
P
P
D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D006801:Humans
D042462:4-Quinolones; D000890:Anti-Infective Agents