title: A yeast actin-binding protein is encoded by SAC6, a gene found by suppression of an actin mutation.
abstract: The protein encoded by SAC6, a gene that can mutate to suppress a temperature-sensitive defect in the yeast actin gene, has been identified as a 67-kilodalton actin-binding protein (ABP 67) that associates with all identifiable actin structures. This finding demonstrates the in vivo functional importance of the actin-ABP 67 interaction previously established in vitro and illustrates the use of suppressor analysis to identify physically interacting proteins.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
authors.forename: A E
authors.initials: AE
authors.lastname: Adams
authors.forename: D
authors.initials: D
authors.lastname: Botstein
authors.forename: D G
authors.initials: DG
authors.lastname: Drubin
mesh_terms: D000199:Actins / Q000235:genetics* / Q000378:metabolism; D005796:Genes; D005800:Genes, Fungal; D008840:Microfilament Proteins / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D015183:Restriction Mapping; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D013489:Suppression, Genetic
chemical_list: D000199:Actins; D008840:Microfilament Proteins