title: Genetics of pertussis toxin.
abstract: Pertussis toxin (PT) is the major virulence factor of Bordetella pertussis. The cloning and nucleotide sequencing of the PT genes from B. pertussis, Bordetella parapertussis and Bordetella bronchiseptica has elucidated the evolution of the Bordetella species and allowed considerable advances towards the understanding of their gene expression and the development of safer vaccines against pertussis.
authors.affiliation: Sclavo Research Centre, Siena, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Gross
authors.forename: B
authors.initials: B
authors.lastname: Aricò
authors.forename: R
authors.initials: R
authors.lastname: Rappuoli
mesh_terms: D001483:Base Sequence; D001884:Bordetella / Q000145:classification / Q000472:pathogenicity; D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D009876:Operon; D037342:Pertussis Toxin; D010802:Phylogeny; D011401:Promoter Regions, Genetic; D014774:Virulence; D010566:Virulence Factors, Bordetella / Q000235:genetics*
chemical_list: D010566:Virulence Factors, Bordetella; D037342:Pertussis Toxin