title: [Multidomain structure of fibrinogen and its transformations].
abstract: Generalized concepts of some structural peculiarities of fibrinogen, its transformation into fibrin and assembly have been considered on the basis of author's and published data. The role of local conformational changes in different areas of fibrinogen molecule and of separate reaction centers in formation of single- and double-stranded rod-like equilibrium fibrin oligomers and flexible branched copolymers of fibrinogen with fibrin E fragment has been considered. The mechanism of compactization has been discussed.
authors.forename: M A
authors.initials: MA
authors.lastname: Rozenfel'd
authors.forename: K B
authors.initials: KB
authors.lastname: Gershkovich
mesh_terms: D000818:Animals; D005337:Fibrin / Q000096:biosynthesis; D005338:Fibrin Fibrinogen Degradation Products / Q000096:biosynthesis; D005340:Fibrinogen / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D046911:Macromolecular Substances; D013329:Structure-Activity Relationship
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D046911:Macromolecular Substances; C011468:fibrinmonomer; D005337:Fibrin; D005340:Fibrinogen
vernacular_title: Mul'tidomennaia struktura fibrinogena i ego prevrashcheniia.