[Current aspects of bacterial resistance to antibiotics].
New aspects of the evolution of bacterial antibiotic resistance are discussed. Dissemination of antibiotic resistance appears to be unlimited since resistance genes from Gram-positive cocci have been detected in Gram negative bacteria. This suggests the occurrence of heterogramic genetic transfers between these phylogenetically distinct organisms. New characters of resistance to beta-lactam antibiotics in enterobacteria result from the apparition of mutant of the TEM-1 and TEM-2 penicillinases. Mutations that confer the capacity to hydrolyze the third generation cephalosporins are located in the active site of the enzymes.
Brisson-Noel
A
A
Unité des Agents Antibactériens, CNRS UA271, Institut Pasteur, Paris.
Trieu-Cuot
P
P
Sougakoff
W
W
Courvalin
P
P
D003227:Conjugation, Genetic; D004352:Drug Resistance, Microbial; D005798:Genes, Bacterial; D006090:Gram-Negative Bacteria / Q000235:genetics*; D006094:Gram-Positive Bacteria / Q000235:genetics*; D006801:Humans; D009154:Mutation; D010641:Phenotype; D010957:Plasmids; D001618:beta-Lactamases / Q000235:genetics
D001618:beta-Lactamases
Aspects actuels de la résistance bactérienne aux antibiotiques.