[Experimental study of the action of antimalarial agents with respect to therapy in porphyria. Combined effect of chloroquine and pyrimethamine].
On an experimental model created from semiaerobically cultivated yeast cells of Caccharomyces cerevisiae (RIMB-75) the authors tested the effect of antimalarics used or tested for treatment of symptomatic liver porphyria. Chloroquine and pyrimethamine inhibited the synthesis of porphyrins, whereby pyrimethamine was more effective. Chloroquine released moreover intracellular porphyrins, contrary to pyrimethamine, which caused their intracellular cumulation. An equimolar combination of the two preparations preserved the inhibitory action of pyrimethamine, and the intracellular porphyrin content was reduced. Based on experimental results the suggested combination of chloroquine and pyrimethamine was successfully tested in clinical work.
Kotal
P
P
Jirsa
M
M
Kaláb
M
M
Kordac
V
V
D002738:Chloroquine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D011164:Porphyrias / Q000188:drug therapy; D011166:Porphyrins / Q000096:biosynthesis*; D011739:Pyrimethamine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012441:Saccharomyces cerevisiae / Q000378:metabolism
D011166:Porphyrins; D002738:Chloroquine; D011739:Pyrimethamine
Experimentální studium mechanismu úcinku antimalarik se zretelem k terapii porfyrické choroby. Kombinovaný úcinek chlorochinu a pyrimetaminu.