title: A modified formula of GIK (glucose-insulin-potassium) therapy for treatment of extensive burn injury in dogs.
abstract: The effectiveness of a modified glucose-insulin-potassium (GIK) formula, which was derived from the results of a previous study (the maximal glucose disposal rate of 400 mg/M2/min required an insulin infusion rate at 1,200 mU/M2/min and KCl supplement rate at 0.08 mEq/M2/min), was evaluated in the treatment of extensive acute burn injury (EABI) in dogs. Under anesthesia initially with intravenous sodium pentobarbital 35 mg/kg followed by a maintenance dose of 5 mg/kg/hr, a third-degree burn of about 50% of the total body surface was created by acetylene torch over the ventral wall of the chest and abdomen. Cardiovascular parameters including heart rate, mean arterial blood pressure, pulmonary wedge pressure, cardiac index, and cardiac contractility (dP/dt of left ventricular pressure), as well as blood chemical data of pH value and K+ concentration were monitored. The present GIK therapy in EABI dogs effectively prevented a decrease in cardiac function, markedly enhanced cardiac function, steadily prolonged cardiac enhancement, and safely avoided hypoglycemic attack.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Veterans General Hospital, Taipei, Taiwan, Republic of China.
authors.forename: R H
authors.initials: RH
authors.lastname: Fang
authors.forename: J S
authors.initials: JS
authors.lastname: Chen
authors.forename: J T
authors.initials: JT
authors.lastname: Lin
authors.forename: Y H
authors.initials: YH
authors.lastname: King
authors.forename: J S
authors.initials: JS
authors.lastname: Kuo
mesh_terms: D000208:Acute Disease; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002056:Burns / Q000628:therapy*; D002314:Cardioplegic Solutions / Q000008:administration & dosage*; D004285:Dogs; D005440:Fluid Therapy; D005947:Glucose / Q000008:administration & dosage; D006321:Heart / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects; D007003:Hypoglycemia / Q000517:prevention & control*; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage; D007552:Isotonic Solutions; D011188:Potassium / Q000008:administration & dosage; D011897:Random Allocation; D000077325:Ringer's Lactate
chemical_list: D001786:Blood Glucose; D002314:Cardioplegic Solutions; D007328:Insulin; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; C030396:glucose-insulin-potassium cardioplegic solution; D005947:Glucose; D011188:Potassium