Effect of attachment of anticandidal antibody to the surfaces of liposomes encapsulating amphotericin B in the treatment of murine candidiasis.
The effect produced by antibody specific to Candida albicans when attached to liposomes containing amphotericin B was studied in vivo. Liposomal amphotericin B bearing specific immunoglobulin (LAMB-Ab) was compared with the unencapsulated drug (fAMB) and other liposomal amphotericin B formulations in the short-term survival (21 days) of mice with disseminated candidiasis. Both the treatment and prophylaxis of the murine model of candidiasis were explored in these trials. LAMB-Ab increased survival rates in the model more than other liposomal preparations containing amphotericin B. Liposomal amphotericin B compounds as a group prolonged survival over fAMB. Liposomal preparations used for comparison included liposomes with attached nonspecific antibody (LAMB-Ab-), liposomes without antibody (LAMB), and liposomes with unattached specific antibody (LAMB+).
Hospenthal
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DR
Department of Botany and Plant Pathology, College of Human Medicine, Michigan State University, East Lansing 48824.
Rogers
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AL
Beneke
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ES
D000666:Amphotericin B / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D000908:Antibodies, Fungal / Q000008:administration & dosage* / Q000494:pharmacology; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000188:drug therapy*; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D008081:Liposomes; D051379:Mice
D000908:Antibodies, Fungal; D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B