title: The effects of haloperidol on discrimination learning and behavioral symptoms in autistic children.
abstract: This double-blind and placebo-controlled clinical trial in autistic children had three objectives: (a) to replicate earlier findings that haloperidol administration is associated with a significant reduction of behavioral symptoms; (b) to further assess its safety when given on a short-term basis; and (c) to assess whether it has an effect on discrimination learning. Forty-five children, 2.02 to 7.58 years old (M = 4.49), completed this crossover design, with random assignment to treatment sequences. Haloperidol was shown to be a powerful therapeutic agent when administered for 4 weeks and free of side effects; at doses ranging from 0.25 to 4.0 mg/day (M = 0.844), there was a clinically and statistically significant reduction of a variety of symptoms. Under the given conditions, the children failed to learn on either haloperidol or placebo.
authors.affiliation: Department of Psychiatry, New York University Medical Center, New York 10016.
authors.forename: L T
authors.initials: LT
authors.lastname: Anderson
authors.forename: M
authors.initials: M
authors.lastname: Campbell
authors.forename: P
authors.initials: P
authors.lastname: Adams
authors.forename: A M
authors.initials: AM
authors.lastname: Small
authors.forename: R
authors.initials: R
authors.lastname: Perry
authors.forename: J
authors.initials: J
authors.lastname: Shell
mesh_terms: D001321:Autistic Disorder / Q000188:drug therapy*; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004193:Discrimination Learning / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006220:Haloperidol / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011897:Random Allocation
chemical_list: D006220:Haloperidol