title: The metabolic behaviour of uranium octoxide bearing residues after their deposition in the rat lung: the implications for occupational exposure.
abstract: This paper describes the metabolic behaviour in rats of uranium inhaled as a U3O8 bearing residue. The biokinetic behaviour of uranium in workers has been predicted by combining the transfer rates to blood in rats with mucociliary clearance rates obtained from human volunteers exposed to other aerosols. It is concluded that chest monitoring will be of value for assessing acute and chronic intakes of the residue below the proposed annual limit (6 x 10(3) Bq) whilst urinary excretion data should be interpreted with caution.
authors.affiliation: National Radiological Protection Board, Didcot, Oxon, UK.
authors.forename: G N
authors.initials: GN
authors.lastname: Stradling
authors.forename: J W
authors.initials: JW
authors.lastname: Stather
authors.forename: S A
authors.initials: SA
authors.lastname: Gray
authors.forename: J C
authors.initials: JC
authors.lastname: Moody
authors.forename: A
authors.initials: A
authors.lastname: Hodgson
mesh_terms: D000395:Air Pollutants, Occupational / Q000032:analysis; D000818:Animals; D004784:Environmental Monitoring / Q000592:standards; D005260:Female; D008168:Lung / Q000378:metabolism*; D051381:Rats; D014501:Uranium / Q000378:metabolism* / Q000652:urine; D017974:Uranium Compounds
chemical_list: D000395:Air Pollutants, Occupational; D017974:Uranium Compounds; D014501:Uranium; C047385:uranium oxide