Simultaneous evaluation of insulin secretion and action using a model.
For the simultaneous evaluation of insulin secretion and insulin sensitivity, a glucose regulation model has been developed. In order to estimate the parameters of the model, an intravenous glucose infusion test (GIT, 100 mg/kg.min x 2 min and 10 mg/kg.min x 118 min) was carried out on 15 healthy subjects (N), 12 subjects with impaired glucose tolerance (IGT), 20 non-insulin-dependent diabetics (NIDDM) and 13 patients with chronic pancreatitis (CP). The coefficient (microU/mg) for insulin secretion depending on blood glucose concentration in IGT, NIDDM and CP were lower (35.9 +/- 2.7, 24.5 +/- 3.3, 43.1 +/- 3.1) than in N (77.5 +/- 7.9). The coefficients (microU.min/mg) for insulin secretion depending on rate of change in blood glucose concentration in IGT and NIDDM were significantly lower (6.5 +/- 2.1, 3.8 +/- 1.2) than in N (52.8 +/- 8.8). The insulin sensitivity index (ISI; 10(-2) mg/(microU/ml).kg.min) in NIDDM was lower (4.98 +/- 0.75) than in N (11.37 +/- 1.08). Administration of exogenous insulin did not significantly affect the value of ISI in N and NIDDM. ISI showed a tendency to increase (15.09 +/- 1.92) in CP. It was demonstrated that the proposed model which estimates both insulin secretory ability and insulin sensitivity simultaneously is quite useful for analyzing the mechanism of impaired glucose tolerance.
Yamasaki
Y
Y
First Department of Medicine, Osaka University Medical School, Japan.
Kawamori
R
R
Tohdo
R
R
Nomura
M
M
Kubota
M
M
Kamada
T
T
Shichiri
M
M
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002908:Chronic Disease; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology*; D007328:Insulin / Q000097:blood / Q000378:metabolism* / Q000502:physiology; D000078790:Insulin Secretion; D007700:Kinetics; D008433:Mathematics; D008875:Middle Aged; D008962:Models, Theoretical; D010195:Pancreatitis / Q000503:physiopathology*; D012016:Reference Values
D001786:Blood Glucose; D007328:Insulin