title: Assessment and management of donor pain following marrow harvest for allogeneic bone marrow transplantation.
abstract: We studied the time course and intensity of pain of multiple bone marrow aspirations in 30 healthy adult marrow donors receiving acetaminophen with codeine for analgesia immediately after marrow harvesting for allogeneic bone marrow transplantation. Upon discharge, donors were supplied with acetaminophen (315 mg) plus codeine (30 mg) tablets and instructed to use one or two tablets up to every 4 h as needed for pain control. Donors used analgesic medication for a mean (+/- SE) of 3.3 +/- 0.5 days (range = 1-13 days) and reported less than complete pain relief. Subjects reported more pain at time of medication than between doses, indicating that the analgesic was at least partially effective. Male donors tended to report more pain and use more analgesic than did females. We conclude that donors self-regulate their analgesic usage to achieve maximal relief and that incomplete relief with acetaminophen plus codeine may be due to limited efficacy of this analgesic preparation. Our findings suggest that donor pain management may be improved by use of more powerful analgesics.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
authors.forename: H F
authors.initials: HF
authors.lastname: Hill
authors.forename: C R
authors.initials: CR
authors.lastname: Chapman
authors.forename: T L
authors.initials: TL
authors.lastname: Jackson
authors.forename: K M
authors.initials: KM
authors.lastname: Sullivan
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D003061:Codeine / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000209:etiology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control; D012737:Sex Factors; D014019:Tissue Donors
chemical_list: D000700:Analgesics; D000082:Acetaminophen; D003061:Codeine