Toward a quantitative comparative toxicology of organic compounds.
Correlation equations between logP (P = octanol water partition coefficient) and the biological activity of alcohols has been derived for 101 examples on all sorts of systems, from simple proteins to whole animals. This provides an overview of the toxic nature of hydrophobic compounds which can be used as a basis for comparison of more complex chemicals. About 100 examples of the hydrophobic effects of chemicals, other than alcohols, to various living systems or their parts are presented for comparison. It is clear that hydrophobic xenobiotics are toxic to almost every form of life, including humans (or parts there of).
Hansch
C
C
Department of Chemistry, Pomona College, Claremont, California.
Kim
D
D
Leo
A J
AJ
Novellino
E
E
Silipo
C
C
Vittoria
A
A
D000818:Animals; D006801:Humans; D013045:Species Specificity; D014116:Toxicology