High incidence of primary cerebral lymphoma in tumor-induced central neurogenic hyperventilation.
An awake patient presented with central neurogenic hyperventilation induced by a cerebral tumor. Corticosteroid therapy and brain irradiation while the patient was anesthetized and respiration controlled under pancuronium-induced respiratory paralysis were followed by tumor regression and resolution of hyperventilation. Recurrence of tumor 6 weeks later was not accompanied by recurrence of hyperventilation. Cytologic study of cerebrospinal fluid revealed B-cell lymphoma. This patient brings to 10 the number of cases recorded with tumor-induced central neurogenic hyperventilation. Five of the eight patients with known tumor histology had a primary cerebral lymphoma, a rare neoplasm that comprises only 1% of all intracranial neoplasms. The disproportionately high frequency of central neurogenic hyperventilation in patients with cerebral lymphoma has therapeutic implications that are briefly reviewed.
Pauzner
R
R
Department of Medicine E, Chain Sheba Medical Center, Tel Hashomer, Israel.
Mouallem
M
M
Sadeh
M
M
Tadmor
R
R
Farfel
Z
Z
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001932:Brain Neoplasms / Q000150:complications* / Q000503:physiopathology / Q000532:radiotherapy; D003131:Combined Modality Therapy; D003964:Diaphragm / Q000187:drug effects; D005260:Female; D006801:Humans; D006985:Hyperventilation / Q000209:etiology* / Q000503:physiopathology; D008223:Lymphoma / Q000150:complications* / Q000503:physiopathology / Q000532:radiotherapy; D008875:Middle Aged; D010197:Pancuronium / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D000305:Adrenal Cortex Hormones; D010197:Pancuronium