[The use of lysosomotropic preparations in treating severe experimental chemical eye burns].
The action of membranotropic preparations--mildronat and phosphaden on the course of a severe burn process of the cornea with changes in lysosomal membranes revealed in pathogenesis has been studied in 80 rabbits. As a marking lysosomal enzyme, acid phosphatase was used. Besides this, peculiarities of the clinical course of the burn process have been studied, when treated by common methods and in a complex with the mentioned preparations. The results of the study have shown expressed stabilizing action of the preparations on lysosomal membranes of the cornea in early terms of the treatment, correlative relationship between results of biochemical investigations and clinical manifestations of the action of membranotropic preparations, high effectiveness of therapeutic action of mildronat as compared with phosphaden. The results obtained can serve as a foundation for the usage of the preparations in complex treatment of patients with severe chemical burns of the eye.
Logaĭ
I M
IM
Guseva
O G
OG
Kalvin'sh
I Ia
IIa
D000208:Acute Disease; D000249:Adenosine Monophosphate / Q000627:therapeutic use*; D000818:Animals; D002057:Burns, Chemical / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology; D002424:Caustics; D003315:Cornea / Q000187:drug effects / Q000201:enzymology; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005126:Eye Burns / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008763:Methylhydrazines / Q000627:therapeutic use*; D011817:Rabbits; D013997:Time Factors
D002424:Caustics; D008763:Methylhydrazines; D000249:Adenosine Monophosphate; C050147:3-(2,2,2-trimethylhydrazine)propionate
Primenenie lizosomotropnykh preparatov v lechenii tiazhelykh khimicheskikh ozhogov v éksperimente.