Micropharmacokinetics of chemical modifiers.
Classical pharmacokinetic analysis of plasma, urine and tissue specimens continues to be of major value to the rational development of chemical modifiers of cancer treatment. However, in addition, increasingly sophisticated analytical techniques are becoming available which allow the pathways of microdistribution and micrometabolism of drugs to be traced down to the cellular and molecular level. New developments described here include flow cytometry, magnetic resonance spectroscopy, and molecular enzymology. These are predicted to have a major impact on the optimization of chemical modification.
Workman
P
P
MRC Clinical Oncology and Radiotherapeutics Unit, MRC Centre, Cambridge, UK.
D000818:Animals; D002478:Cells, Cultured; D005434:Flow Cytometry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism*; D009593:Nitroimidazoles / Q000493:pharmacokinetics*; D010100:Oxygen / Q000378:metabolism*; D011838:Radiation-Sensitizing Agents / Q000493:pharmacokinetics*; D014407:Tumor Cells, Cultured
D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; D010100:Oxygen