title: Occupational exposure to organic solvents causing chronic tubulointerstitial nephritis.
abstract: We describe a patient with a history of ulcerative colitis and long-standing occupational exposure to organic solvents. Over a follow-up period of almost four years he had progression of tubulointerstitial damage documented by two kidney biopsies. We propose that long-term exposure to organic solvents can lead to the development of chronic tubulointerstitial nephritis. We describe experimental evidence that supports our conclusion.
authors.affiliation: Department of Internal Medicine, James A. Haley Veterans Administration Hospital, Tampa, FL 33612.
authors.forename: J
authors.initials: J
authors.lastname: Narvarte
authors.forename: S R
authors.initials: SR
authors.lastname: Saba
authors.forename: G
authors.initials: G
authors.lastname: Ramirez
mesh_terms: D000328:Adult; D000401:Aircraft; D002908:Chronic Disease; D006801:Humans; D006838:Hydrocarbons / Q000009:adverse effects; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D009784:Occupational Diseases / Q000139:chemically induced*; D012997:Solvents / Q000009:adverse effects*
chemical_list: D006838:Hydrocarbons; D012997:Solvents