title: Correlation between the growth and killing curves of Escherichia coli in the presence of cefotetan or piperacillin.
abstract: Escherichia coli strains that were susceptible to multiple antibiotics were exposed to cefotetan and piperacillin. As with the majority of beta-lactam antibiotics, the growth curves showed an increase in optical density (OD) due to an increasing volume of cell-wall-deficient bacteria during the first hours before lysis. This increase in OD depended on the concentration of cefotetan and was less dependent on the concentration of piperacillin. A good correlation was found between the prelytic increase in OD and the killing curve. During the prelytic increase in OD, the number of CFU/ml remained more or less constant. The decrease in the number of CFU/ml depended on the concentration of cefotetan and was less dependent on the concentration of piperacillin.
authors.affiliation: Department of Microbiology, Brugmann University Hospital, Brussels, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Yourassowsky
authors.forename: M P
authors.initials: MP
authors.lastname: Van der Linden
authors.forename: M J
authors.initials: MJ
authors.lastname: Lismont
authors.forename: F
authors.initials: F
authors.lastname: Crokaert
authors.forename: Y
authors.initials: Y
authors.lastname: Glupczynski
mesh_terms: D015313:Cefotetan / Q000494:pharmacology*; D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development*; D008826:Microbial Sensitivity Tests; D010878:Piperacillin / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D003470:Culture Media; D015313:Cefotetan; D010878:Piperacillin