LHRH and LH in peripubertal female rats following prenatal and/or postnatal ethanol exposure.
The effects of pre- and postnatal exposure to ethanol (ETOH) on LHRH and LH were investigated. Pregnant and/or lactating dams were fed ETOH during: 1) gestation, 2) lactation, or 3) gestation-lactation. Female offspring were decapitated at 30 or 40 days-of-age; trunk blood was collected for plasma LH RIA; and hypothalamic tissues were collected for LHRH RIA. Hypothalamic LHRH content of all ETOH-exposed groups was less than that of non-ETOH-fed controls at 30 and 40 days-of-age (p less than 0.05). Plasma LH concentrations of all ETOH-exposed groups were less than those of non-ETOH-fed controls at 30 and 40 days-of-age (p less than 0.05). Also, at 30 and 40 days-of-age, the plasma LH concentrations of the animals exposed to ETOH during lactation and gestation-lactation were less than those of the animals exposed to ETOH during gestation (p less than 0.05). These data suggest that ETOH exposure during gestation and/or lactation negatively affects hypothalamic LHRH content of female rat offspring. Decreased hypothalamic LHRH content with corresponding lowered plasma LH concentration suggests that ETOH influences development or maturation of hypothalamic LHRH neurons by possibly decreasing their number or synthesizing capability.
Morris
D L
DL
Department of Veterinary Anatomy, College of Veterinary Medicine, Texas A&M University, College Station 77843.
Harms
P G
PG
Petersen
H D
HD
McArthur
N H
NH
D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000097:blood / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology; D007774:Lactation; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012741:Sexual Maturation
D007987:Gonadotropin-Releasing Hormone; D000431:Ethanol; D007986:Luteinizing Hormone