title: Alterations in the nuclear volume of neurones from the hypothalamic magnocellular nuclei of fetuses born to rats subject to chronic alcoholism.
abstract: Previous authors have noticed alterations of the neuroendocrine system in the offspring of chronically alcoholic animals. Forty Sprague-Dawley rats, were used fed a liquid control diet and a 5%-alcohol liquid diet (Lieber and DeCarli). They were divided into four groups: Control (C), Pair Fed (P), Embryonic alcohol (E) and Fetal alcohol (F). Results obtained in the statistical analysis were as follows: from the paraventricular nucleus: between E and F, E and P, E and C, p less than 0.001. F and C p less than 0.01. P and C p less than 0.005. Between F and P there were no significant differences. From the supraoptic nucleus: E and P, E and C p less than 0.001. F and P p less than 0.025, F and C p less than 0.01. Between E and F, P and C there were no significant differences.
authors.affiliation: Departamento de Pediatría, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Fresnillo
authors.forename: I
authors.initials: I
authors.lastname: Villa-Elízaga
authors.forename: A
authors.initials: A
authors.lastname: Olazabal
authors.forename: E
authors.initials: E
authors.lastname: Frizell
authors.forename: J A
authors.initials: JA
authors.lastname: López de Ochoa
authors.forename: A
authors.initials: A
authors.lastname: Ballesteros
authors.forename: L
authors.initials: L
authors.lastname: Sierrasesúmaga
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000473:pathology*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000473:pathology*; D009474:Neurons / Q000648:ultrastructure*; D010286:Paraventricular Hypothalamic Nucleus / Q000196:embryology / Q000473:pathology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013495:Supraoptic Nucleus / Q000196:embryology / Q000473:pathology*