Ethanol induced teratogenesis: characterization, mechanisms and diagnostic approaches.
Extensive research has been aimed at characterising FAS and FAE. Whereas the symptomology for FAS has been established, that of FAE remains to be fully characterized. Various mechanisms of ethanol induced teratogenesis have been proposed however it remains to be defined how these mechanisms combine to produce the entire constellation of teratogenic characteristics observed. At present, impaired placental transport, abnormal muscle organogenesis and fetal hypoxia have limitations in explaining the entire spectrum of defects in FAS. The role of prostaglandins and hormones requires further research. Also, other as yet unidentified mechanisms may exist. Even if the composite mechanism can be established, ethanol effects in utero will likely not be preventable by any approach other than consumption modification. In light of this notion, future research into identifying high-risk pregnant drinkers for clinical intervention is emphasized. Intervention leading to abstinence or, if this is not possible, removing the infant as early as possible from an intrauterine environment that is causing growth retardation and fetal distress, are the only solutions available at present.
Hoyseth
K S
KS
Division of Human Nutrition, School of Family and Nutritional Sciences, University of British Columbia, Vancouver.
Jones
P J
PJ
D000014:Abnormalities, Drug-Induced; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders; D005865:Gestational Age; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
D000431:Ethanol