LL-E19085 alpha, a novel antibiotic from Micromonospora citrea: taxonomy, fermentation and biological activity.
A new antibacterial antibiotic, designated LL-E19085 alpha, was isolated from the fermentation broth of an actinomycete strain. Based on cultural, physiological, morphological and chemical characteristics, culture LL-E19085 was identified as a new subspecies of Micromonospora citrea. Antibiotic LL-E19085 alpha demonstrated potent activity against a spectrum of Gram-positive aerobic and anaerobic bacteria.
Maiese
W M
WM
Medical Research Division, American Cyanamid Company, Lederle Laboratories, Pearl River, New York 10965.
Lechevalier
M P
MP
Lechevalier
H A
HA
Korshalla
J
J
Goodman
J
J
Wildey
M J
MJ
Kuck
N
N
Greenstein
M
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects*; D003470:Culture Media; D005285:Fermentation; D051379:Mice; D008847:Micromonospora / Q000145:classification / Q000254:growth & development / Q000378:metabolism* / Q000648:ultrastructure; D008854:Microscopy, Electron; D015394:Molecular Structure; D010080:Oxazoles / Q000096:biosynthesis / Q000494:pharmacology / Q000627:therapeutic use; D013171:Spores, Bacterial / Q000648:ultrastructure; D013290:Streptococcal Infections / Q000188:drug therapy*; D013297:Streptococcus pyogenes / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003470:Culture Media; D010080:Oxazoles; C060116:citreamicin alpha