title: Preparation of a functional, highly selective polymer by molecular imprinting. A demonstration with L-p-aminophenylalanine anilide as a template molecule allowing multiple points of attachment.
abstract: The technique of molecular imprinting was tested using various phenylalanine derivatives. It could be shown that polymers obtained by imprinting with L-p-aminophenylalanine anilide gave best recognition of the original L-form, with separation factors (alpha) above 8, on applying racemic mixtures to the polymer obtained and present in a HPLC column. We believe that these results are due to multiple points of attachment that are possible between print or template (guest) molecules and the formed polymer (host).
authors.affiliation: Institute of Biotechnology, Federal Institute of Technology, Zürich, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Moradian
authors.forename: K
authors.initials: K
authors.lastname: Mosbach
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006860:Hydrogen Bonding; D010649:Phenylalanine / Q000031:analogs & derivatives*; D011108:Polymers; D013237:Stereoisomerism; D013698:Templates, Genetic
chemical_list: D011108:Polymers; C064503:4-aminophenylalanine anilide; D010649:Phenylalanine