[Usefulness of sublingual captopril in hypertensive emergencies. Preliminary results].
The aim of this study, whose preliminary findings are reported, is to evaluate the efficacy of captopril, administered by a sublingual route, in the treatment of hypertensive emergencies. Captopril has been given by this route to 20 hypertensive patients while these had an ongoing hypertensive crisis (defined as a systolic arterial pressure above 200 mmHg associated with a diastolic arterial pressure above 115 mmHg). Arterial pressure has been measured after 5, 20, 10, 15, 30, 45, 60 and 120 min. For 8 patients it has been measured until the eighth hour. Results were the following: a satisfactory control of hypertensive crisis in 85% of patients, as stated by a slight but significant drop of arterial pressure after 10 min (15/10 mmHg; p less than 0.05) and by a maximum antihypertensive effect after 30 min (57/39 mmHg; p less than 0.001); an antihypertensive effect was evident until 6 hours after the administration of the drug; a positive correlation between the antihypertensive effect and pretreatment levels of arterial pressure and plasma renin activity; drug was free from relevant side effects; sublingual captopril can be considered an efficacious, easy to use and valuable tool in the treatment of hypertensive emergencies.
Guerrera
G
G
Melina
D
D
Capaldi
L
L
Tatulli
C
C
Cardillo
C
C
Guerrera
G
G
Mauro
R
R
Musumeci
V
V
Savi
L
L
Folli
G
G
D000286:Administration, Sublingual; D000328:Adult; D000368:Aged; D002216:Captopril / Q000008:administration & dosage*; D004341:Drug Evaluation; D004630:Emergencies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood; D013997:Time Factors
D002216:Captopril; D012083:Renin
Utilità del captopril sublinguale nelle emergenze ipertensive. Risultati preliminari.