In vivo biosynthesis of thromboxane and prostacyclin during exposure to physiological levels of epinephrine.
The effects of 20-min epinephrine infusion (0.025 and 0.3 nmol/kg/min) on the in vivo synthesis of thromboxane A2 and prostacyclin were studied in ten healthy male volunteers. We assessed the in vivo biosynthesis of thromboxane A2 and prostacyclin by measurement of the urinary metabolites 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha, respectively. Epinephrine infusion did not cause any significant changes in the urinary excretion of the two metabolites. Thus, we conclude that physiological levels of epinephrine do not affect the in vivo biosynthesis of thromboxane A2 and prostacyclin.
Vesterqvist
O
O
Department of Clinical Chemistry and Blood Coagulation, Karolinska Hospital, Stockholm, Sweden.
Rasmanis
G
G
Gréen
K
K
Edhag
O
O
Henriksson
P
P
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology*; D011464:Epoprostenol / Q000096:biosynthesis* / Q000652:urine; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D013931:Thromboxanes / Q000096:biosynthesis* / Q000652:urine
D013931:Thromboxanes; D011464:Epoprostenol; D004837:Epinephrine