title: Captopril: a free radical scavenger.
abstract: The use of captopril in heart failure and hypertension is becoming increasingly accepted. Captopril has a sulphydryl group in its molecular structure. We wondered if this might confer free radical scavenging activity on the drug and have investigated this in an in vitro system. Results show that captopril is a free radical scavenger and we suggest that this action might be relevant in its use in heart failure and other vascular diseases.
authors.affiliation: University Departments of Medicine and Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee.
authors.forename: M
authors.initials: M
authors.lastname: Chopra
authors.forename: N
authors.initials: N
authors.lastname: Scott
authors.forename: J
authors.initials: J
authors.lastname: McMurray
authors.forename: J
authors.initials: J
authors.lastname: McLay
authors.forename: A
authors.initials: A
authors.lastname: Bridges
authors.forename: W E
authors.initials: WE
authors.lastname: Smith
authors.forename: J J
authors.initials: JJ
authors.lastname: Belch
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000378:metabolism; D000818:Animals; D002216:Captopril / Q000378:metabolism*; D005609:Free Radicals; D006801:Humans
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D005609:Free Radicals; D002216:Captopril