Effect of the chronic ethanol action on the activity of the general amino-acid permease from Saccharomyces cerevisiae var. ellipsoideus.
The presence of ethanol and cycloheximide during growth were found to inhibit the function of the general amino-acid permease of Saccharomyces cerevisiae var. ellipsoideus. Contrary to cycloheximide, the effect of ethanol upon growth in alcohol-free medium was reversible. The effect of both inhibitors could be explained in terms of reduction of the number of active carrier molecules located in the plasma membrane.
Ferreras
J M
JM
Departamento de Bioquímica, Biología Molecular y Fisiología, Facultad de Ciencias, Universidad de Valladolid, Spain.
Iglesias
R
R
Girbés
T
T
D026905:Amino Acid Transport Systems; D001667:Binding, Competitive; D001692:Biological Transport; D003513:Cycloheximide / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D049990:Membrane Transport Modulators; D026901:Membrane Transport Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010649:Phenylalanine / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D014633:Valine / Q000378:metabolism
D026905:Amino Acid Transport Systems; D049990:Membrane Transport Modulators; D026901:Membrane Transport Proteins; D000431:Ethanol; D010649:Phenylalanine; D003513:Cycloheximide; D014633:Valine