title: [AL amyloidosis and primary fibrinolysis. Study of the mechanism of fibrinolysis].
abstract: A 45 years old woman with AL amyloidosis presented with a hypofibrinogenemia (fibrinogen 100 mg/dl) without severe bleeding. There was laboratory evidence of fibrinolysis with shortened euglobulin lysis time, decreased alpha-2 plasmin inhibitor and decreased plasminogen. The mechanism of this primary fibrinolysis remains unclear, since there is no enhancement of the tissue-type plasminogen activator. Analysis of the 8 cases related in the literature of excessive fibrinolysis associated with amyloidosis demonstrated improvement of bleeding manifestations and abnormal fibrinolysis following the administration of antifibrinolytic agents.
authors.affiliation: Service de Médecine Interne, Hôpital Pitié-Salpêtrière, Paris.
authors.forename: P
authors.initials: P
authors.lastname: Boudes
authors.forename: M H
authors.initials: MH
authors.lastname: Horellou
authors.forename: O
authors.initials: O
authors.lastname: Bletry
authors.forename: A V
authors.initials: AV
authors.lastname: Bendetowicz
authors.forename: G
authors.initials: G
authors.lastname: Nguyen
authors.forename: J
authors.initials: J
authors.lastname: Conard
authors.forename: E
authors.initials: E
authors.lastname: Vidal
authors.forename: P
authors.initials: P
authors.lastname: Godeau
authors.forename: M
authors.initials: M
authors.lastname: Samama
mesh_terms: D000682:Amyloid; D000686:Amyloidosis / Q000503:physiopathology*; D005260:Female; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D008875:Middle Aged
chemical_list: D000682:Amyloid; C035222:amyloid protein AL
vernacular_title: Amylose AL et fibrinolyse primaire. Etude du mécanisme de la fibrinolyse.