Genetic epidemiology of persistent islet cell antibodies among IDDM patients.
The persistence of cytoplasmic islet cell antibodies (ICA) more than a year after diagnosis of insulin-dependent diabetes mellitus (IDDM) was investigated in 43 families with at least two children with IDDM. The prevalence of persistent ICA among IDDM patients was 16%. Persistence of ICA appeared to be familial in that siblings with IDDM were significantly more concordant for the presence or for the absence of ICA than expected by chance (P = 0.04). Patients with persistent ICA were older on average at onset of IDDM than patients without persistent ICA after adjusting for duration of disease (P = 0.004). Persistence of ICA was not significantly associated with HLA DR type, immunoglobulin genotype, insulin allele class, sex, history of viral diseases, or prior vaccinations.
Newman
B
B
School of Public Health, University of California, Berkeley 94720.
Selby
J
J
Lee
M
M
King
M C
MC
D001323:Autoantibodies / Q000032:analysis*; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D009656:North America
D001323:Autoantibodies; D006684:HLA-DR Antigens