[The inhibitory effect of apolipoproteins in HDL on experimental atherosclerosis in rabbits].
The main apolipoproteins in HDL are known to be apo A1, A2, and A4. Apolipoprotein (mainly apo A1) were isolated and purified from about 100 liters of rabbit's serum for the purpose of studying their inhibitory effect on the development of atheromatous plaques in rabbits. Data indicated that lipid content in aortic intima: lipid deposition in intima morphologically; area of atheromatous lesion involved and the severity of atheromatous lesions obtained were much lower in animals of the experimental group after intravenous administration of apolipoproteins isolated from HDL for 8 to 12 weeks than those in animals of the cholesterol control groups in two successive experiments. In accordance with data obtained from epidemiological and experimental surveys. HDL level was known to be correlated reversely with the incidence of atherosclerosis. Data of these experiments confirmed that apolipoproteins (mainly apoA1) in HDL are the main factors of this inhibitory effect. This result provides a scientific basis for the measurement of preparation of certain apolipoproteins (apo A1 and possibly A1) by high bio-technology for prevention and treatment of atherosclerosis in the near future.
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D000818:Animals; D001011:Aorta / Q000648:ultrastructure; D001054:Apolipoproteins A / Q000302:isolation & purification / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D008075:Lipoproteins, HDL / Q000032:analysis*; D008297:Male; D011817:Rabbits
D001054:Apolipoproteins A; D008075:Lipoproteins, HDL