Induction of the metastatic phenotype by transfection of the nuclear oncogene p53: increases in cytoplasmic diacylglycerol levels and reduction in class I major histocompatibility antigen expression are not sufficient to explain the changes in metastatic capacities.
Transfection of the oncogene encoding the nuclear protein p53 into a low-metastatic mouse carcinoma cell line resulted in enhanced metastatic capabilities in clones that showed increased p53 protein expression [Pohl J, Goldfinger N, Radler-Pohl A, Rotter V, Schirrmacher V (1988) Mol Cell Biol 8:2078-2081]. This effect seemed neither to be due to increase in cytoplasmic diacylglycerol levels nor to reduced cell-surface expression of class I major histocompatibility antigens.
Pohl
J
J
German Cancer Research, Institute for Immunology and Genetics, Heidelberg.
Lehmann
V
V
Radler-Pohl
A
A
Schirrmacher
V
V
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000032:analysis; D002999:Clone Cells; D003593:Cytoplasm / Q000378:metabolism; D004075:Diglycerides / Q000378:metabolism*; D011905:Genes, ras; D005989:Glycerides / Q000378:metabolism*; D006183:H-2 Antigens / Q000032:analysis; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009362:Neoplasm Metastasis / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D010641:Phenotype; D010750:Phosphoproteins / Q000235:genetics*; D014162:Transfection; D016159:Tumor Suppressor Protein p53; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000276:immunology
D004075:Diglycerides; D005989:Glycerides; D006183:H-2 Antigens; D015395:Histocompatibility Antigens Class I; D009363:Neoplasm Proteins; D010750:Phosphoproteins; D016159:Tumor Suppressor Protein p53