[Possibility of using intracavitary perfusion hyperthermia in the treatment of gastric cancer: an study of its local and systemic effects].
The selective lethal effect of heat on neoplastic cells has been demonstrated by several experiments "in vitro" and "in vivo". In this paper the authors report their experience on endocavitary-hyperthermic perfusion of the stomach, performed with a hyperthermic-perfusion system invented and built by them. 12 rabbits were submitted to hyperthermic perfusion of the stomach at 42.5 C for a period of 50 minutes under general anesthesia. Three other rabbits were treated with normothermic perfusion for a further control. Rectal temperature was monitored during perfusion and gastric pH was evaluated after treatment by a gastrectomy. Neither death nor major complications were observed during and after treatment and physiologic functions were maintained. Animals were sacrificed at different times from the treatment and macroscopic and microscopic exams of the principal organs were performed. Edema of the gastric wall was present in rabbits killed after a short time from treatment, while it was absent in animals sacrificed after a longer time; in these animals normal aspect of gastric glands and no fibroblastic activity was evident. The authors consider the possibility of employing this treatment in curing advanced gastric cancer, eventually associated with hyperthermic perfusion of abdominal cavity.
Giori
A
A
Campisi
C
C
Sperandio
M
M
D000818:Animals; D005069:Evaluation Studies as Topic; D005260:Female; D006979:Hyperthermia, Induced / Q000379:methods*; D008297:Male; D010477:Perfusion; D011817:Rabbits; D013274:Stomach Neoplasms / Q000628:therapy*
Possibilità di impiego dell'ipertermia perfusionale endocavitaria nel trattamento del cancro gastrico: studio dei suoi effetti locali e sistemici.