Further evaluation of the biphasic kinetics of iron removal from transferrin by 3,4-LICAMS.
Further evaluation of the kinetic data for Fe3+ removal from isolated differic and monoferric transferrins by the tricatechol ligand 3,4-LICAMS has allowed full characterization of the four microscopic rate constants. A very small cooperativity exists between the two iron-binding sites with respect to their rates of iron release. The activation free energy profile for the system is presented.
Kretchmar
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SA
Department of Chemistry, University of California, Berkeley 94720.
Raymond
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KN
D007501:Iron; D007502:Iron Chelating Agents; D007700:Kinetics; D008956:Models, Chemical; D013095:Spermidine / Q000031:analogs & derivatives; D013816:Thermodynamics; D014168:Transferrin
D007502:Iron Chelating Agents; D014168:Transferrin; C030662:N,N',N''-tris(2,3-dihydroxy-5-sulfobenzoyl)-1,5,10-triazadecane; D007501:Iron; D013095:Spermidine