[Effect of the acute administration of lithium on various enzymatic activities of the brain].
Modification in several enzyme activities after Li treatment are described. The enzymes under study were Lys-aminopeptidase (Lys-AP), glutamate-oxaloacetate transaminase (GOT), lactate dehydrogenase (LDH) and creatine kinase (CK). The changes observed were as follows: Modifications of Lys-AP activity in the hypothalamus (Ht), pituitary gland and hippocampus (HC); LDH increases in Ht and medulla (Md); CK increases in HC, Ht and Md. No changes were found in GOT activity. It is suggested that these enzymes play a part in the lithium action mechanism.
Gandarias
J M
JM
Departamento de Fisiología, Facultad de Medicina v Odontología, Universidad del País Vasco, Bilbao.
Echevarría
E
E
Irazusta
J
J
Múgica
J
J
Casis
L
L
D000626:Aminopeptidases / Q000378:metabolism*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002531:Cerebellum / Q000187:drug effects / Q000201:enzymology; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology; D003402:Creatine Kinase / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008032:Limbic System / Q000187:drug effects / Q000201:enzymology; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D008094:Lithium; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D000626:Aminopeptidases
Efecto de la administración aguda de litio sobre diversas actividades enzimáticas cerebrales.