title: The effects of hypoxemia with progressive acidemia on fetal renal function in sheep.
abstract: In order to determine the effects of fetal hypoxemia on renal blood flow, glomerular filtration rate (GFR) and urethral and urachal urine output, we examined the effects of 3 h maternally-induced (9% O2, 3% CO2, 88% N2) fetal hypoxaemia on 10 chronically-instrumented fetal sheep between 127-135 days of gestation. Fetal arterial pH fell significantly during the second and third hours of hypoxia and this coincided with a significant increase in fetal arterial blood pressure (P less than 0.05). During the second hour of hypoxia, with mild acidaemia, fetal GFR decreased significantly and then, during the third hour, fetal GFR, urethral and total urine output were significantly elevated. During the 2-h recovery period urachal and total, but not urethral urine output, were significantly elevated (P less than 0.05). The data suggested that the increase in GFR and urine output measured during the third hour of hypoxia and the recovery period may reflect a pressure diuresis.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Western Ontario, Canada.
authors.forename: M E
authors.initials: ME
authors.lastname: Wlodek
authors.forename: J R
authors.initials: JR
authors.lastname: Challis
authors.forename: B
authors.initials: B
authors.lastname: Richardson
authors.forename: J
authors.initials: J
authors.lastname: Patrick
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure; D005260:Female; D005919:Glomerular Filtration Rate; D006340:Heart Rate, Fetal; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000097:blood / Q000150:complications*; D007668:Kidney / Q000196:embryology* / Q000503:physiopathology; D011247:Pregnancy; D012079:Renal Circulation; D012756:Sheep; D014556:Urine