[Metabolic indices of proteolysis of the blood serum in dogs in the early period following uniform whole-body gamma irradiation].
Free amino acid concentration and proteinase inhibitor content were studied during the first 48 h following whole-body uniform gamma irradiation of dogs (LD30/50 and LD90/45). The contribution of metabolic profile features to individual radiosensitivity is discussed on the basis of the retrospective analysis of the initial level of metabolic indices in animals survived and died after irradiation. The comparison of the dynamics of changes in the indices under study in the animals died after exposure to different radiation doses permitted to suggest the important role that early hyperactivation of proteolysis played in the development of metabolism decompensation which promoted the fatal outcome of the affection.
Konnova
L A
LA
Teslenko
V M
VM
Komar
V E
VE
D000596:Amino Acids / Q000097:blood / Q000528:radiation effects; D000818:Animals; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008297:Male; D010447:Peptide Hydrolases / Q000097:blood / Q000528:radiation effects*; D011480:Protease Inhibitors / Q000097:blood / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000201:enzymology* / Q000401:mortality; D011836:Radiation Tolerance; D013045:Species Specificity; D013997:Time Factors; D014916:Whole-Body Irradiation
D000596:Amino Acids; D011480:Protease Inhibitors; D010447:Peptide Hydrolases
Metabolicheskie pokazateli proteoliza v syvorotke krovi sobak v ranniĭ period posle obshchego ravnomernogo gamma-oblucheniia.