[Saliva phenobarbital concentration in epileptics].
The concentrations of phenobarbital were measured in saliva-serum pairs obtained simultaneously from 33 epileptics by RIA. The mean concentration of phenobarbital in saliva was 3.2 +/- 1.78 micrograms/ml, in serum was 11.75 +/- 7.4 micrograms/ml, the mean saliva-to-serum ratio for phenobarbital was 0.27 +/- 0.08. The results suggested that saliva concentration of phenobarbital was found to be correlated closely with the total serum level (R = 0.7922, P less than 0.01). The high correlation between saliva and serum concentrations supports the use of saliva measurement in epileptics. The simplicity and convenience of saliva collection and its noninvasiveness make it represent serum concentration of phenobarbital as an efficient monitoring method.
Shen
D
D
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012463:Saliva / Q000378:metabolism*
D010634:Phenobarbital