Biochemical changes associated with blood pressure reduction induced by calcium supplementation during pregnancy.
In a study population that comprised 34 normal black pregnant women, biochemical changes are compared between a group of women who received 1.5 gm of calcium supplementation a day and a group of women who received placebos. The blood pressure-lowering effect of calcium supplementation appears to involve a mechanism that relates parathyroid hormone and plasma renin activity. Other alterations in calcium and magnesium metabolism, as reflected by increased urinary calcium excretion and serum magnesium levels, may also contribute to this effect. Subgroups of study participants with initial (less than 26 weeks' gestation) low levels of serum calcium and plasma renin activity are the ones with the largest reductions in blood pressure. Whether these alterations can produce a reduction in the incidence of pregnancy-induced hypertension is the next question to be answered in this area.
Repke
J T
JT
Department of Gynecology and Obstetrics, Johns Hopkins Hospital, Baltimore, MD 21205.
Villar
J
J
Anderson
C
C
Pareja
G
G
Dubin
N
N
Belizan
J M
JM
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000494:pharmacology* / Q000652:urine; D015237:Dinoprost / Q000097:blood; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D011247:Pregnancy / Q000502:physiology*; D011262:Pregnancy Trimester, Second; D011403:Pronation; D012083:Renin / Q000097:blood
D010281:Parathyroid Hormone; D015237:Dinoprost; D012083:Renin; D008274:Magnesium; D002118:Calcium