Adrenoceptors and the lung: their role in health and disease.
alpha- and beta-Adrenoceptors have each been divided into two subgroups (alpha 1, alpha 2, beta 1 and beta 2). The basic mechanisms underlying the adrenoceptor/effector coupling are complex and vary for the alpha-, but not for the beta-subpopulations. Adrenoceptors of the bronchi and the lung show a special pattern of distribution and response, ensuring that the airway system works as a functionary unit. Dysfunctions of adrenoceptor-mediated effects have been suggested to contribute to some important paediatric disorders such as hyaline membrane syndrome, wet lung, bronchial asthma, cystic fibrosis, and pertussis. Drugs which act on the adrenergic system influence some of these disorders directly. Further studies applying modern techniques to receptor research are needed in order to clarify the basic mechanisms involved in receptor-mediated lung disorders and the activity of drugs in lung tissue.
Reinhardt
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Universitäts-Kinderklinik, Düsseldorf, Federal Republic of Germany.
D002648:Child; D006801:Humans; D008168:Lung / Q000294:innervation*; D008171:Lung Diseases / Q000503:physiopathology*; D011941:Receptors, Adrenergic / Q000502:physiology*
D011941:Receptors, Adrenergic