Renin-positive granulated Goormaghtigh cells. Immunohistochemical and electron-microscopic studies on biopsies from patients with pseudo-Bartter syndrome.
It is difficult to distinguish between Goormaghtigh cells (G-cells) and media cells of the glomerular arterioles at the border of the Goormaghtigh cell field. Consequently, it has been unclear whether renin-positive G-cells are normally present and also whether renin-producing cells are recruited from the pool of renin-negative G-cells upon stimulation of the renin-angiotensin system (RAS). In the present study, immunohistochemical and electron-microscopic experiments have been carried out on serially sectioned kidney biopsies from four patients with pseudo-Bartter syndrome. The results strongly suggest that with long-lasting stimulation of the RAS all renin-negative ("secretory resting") G-cells are ultimately converted into renin-producing granular cells.
Christensen
J A
JA
Gade Institute, Department of Pathology, University of Bergen, Norway.
Bohle
A
A
Mikeler
E
E
Taugner
R
R
D000328:Adult; D000450:Aldosterone / Q000378:metabolism; D001477:Bartter Syndrome / Q000378:metabolism* / Q000473:pathology; D001706:Biopsy; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D005920:Glomerular Mesangium / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D006929:Hyperaldosteronism / Q000378:metabolism*; D006965:Hyperplasia; D007150:Immunohistochemistry; D007606:Juxtaglomerular Apparatus / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D007668:Kidney / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011453:Prostaglandins / Q000378:metabolism; D012083:Renin / Q000378:metabolism*; D013577:Syndrome
D004573:Electrolytes; D011453:Prostaglandins; D000450:Aldosterone; D012083:Renin