title: [Prevention of stress-induced hemorrhage of the upper gastrointestinal tract in neurosurgical intensive care patients. A controlled, randomized double-blind study with ranitidine alone and in combination with pirenzepine].
abstract: During a controlled, randomized, double blind study, 30 patients of a neurosurgical intensive care unit were treated with ranitidin and placebo (group 1) or ranitidin and pirenzepin (group 2). No significant difference in the effectivity of both methods was established, presumably due to the small number of cases. The pH values of group 2 lay in the median above 3.5, whereby the difference only became statistically significant after a seven-day period of therapy. In how far the increase of the pH value represents the only factor of a stress ulcer prophylaxis requires further investigation, particularly in connection with pulmonary risks caused by this.
authors.forename: B
authors.initials: B
authors.lastname: Krakamp
authors.forename: T
authors.initials: T
authors.lastname: Rommel
authors.forename: M
authors.initials: M
authors.lastname: Edelmann
authors.forename: P
authors.initials: P
authors.lastname: Leidig
mesh_terms: D001930:Brain Injuries / Q000601:surgery*; D003422:Critical Care; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005745:Gastric Acidity Determination; D006801:Humans; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control*; D010890:Pirenzepine / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000517:prevention & control*; D011897:Random Allocation; D011899:Ranitidine; D013315:Stress, Psychological / Q000150:complications*
chemical_list: D010890:Pirenzepine; D011899:Ranitidine
vernacular_title: Prophylaxe stressbedingter Blutungen aus dem oberen Gastrointestinaltrakt bei neurochirurgischen Intensivpatienten. Eine kontrollierte, randomisierte Doppelblindstudie mit Ranitidin allein und in Kombination mit Pirenzepin.