T lymphocyte subpopulations in patients with chronic active hepatitis B virus infection characterized by monoclonal antibodies.
Peripheral blood T lymphocytes and T cell subsets were analyzed in 19 patients with chronic active hepatitis B virus infection. The T cell subpopulations were defined by indirect immuno-fluorescence using monoclonal antibodies, and additionally, natural killer cell activity against K 562 human erythroleukemic cell has also been defined. All investigated patients have possessed nearly identical clinical and biochemical signs of disease, but on the basis of T lymphocyte subpopulations they could be divided into two groups: low CD4/CD8 ratio group and normal or high CD4/CD8 ratio group. Mechanism responsible for such differences remains hypothetical but it seems reasonable to propose different protocol for immunomodulatory treatment of patients in both groups.
Dworniak
D
D
Clinic of Infectious Diseases, Military Medical Academy, Lódź.
Tchórzewski
H
H
Pokoca
L
L
Tkacz
B
B
Drobnik
S
S
Baj
Z
Z
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000378:metabolism*; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000276:immunology; D006511:Hepatitis B Antigens / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000382:microbiology*
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens