title: [Ways of developing the first and second generation biocatalysts for antibiotic production].
abstract: Methods for development of bioengineering systems of different types useful in synthesis and transformation of antibiotics are discussed. It was shown that in development of monoenzymatic biocatalysts on the basis of immobilized cells and in preparation of immobilized cultures producing secondary metabolites with enzymological engineering directed action on the cells could be provided which made it possible to establish highly efficient bioengineering systems. Various means for providing the directed action and method for estimation of the carrier-culture interation are proposed. The prospects of using the second generation biocatalysts in improvement of the processes for production of antibiotics are described.
authors.forename: P S
authors.initials: PS
authors.lastname: Nys
authors.forename: A V
authors.initials: AV
authors.lastname: Skliarenko
authors.forename: P L
authors.initials: PL
authors.lastname: Zaslavskaia
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Bartoshevich
mesh_terms: D002384:Catalysis; D004800:Enzymes, Immobilized; D004926:Escherichia coli / Q000201:enzymology / Q000378:metabolism*; D007218:Industrial Microbiology / Q000379:methods*; D010405:Penicillinase / Q000096:biosynthesis*; D010406:Penicillins / Q000096:biosynthesis*
chemical_list: D004800:Enzymes, Immobilized; D010406:Penicillins; D010405:Penicillinase
vernacular_title: Puti sozdaniia biokatalizatorov pervogo i vtorogo pokoleniia dlia protsessov polucheniia antibiotikov.