Local increase in interleukin-1-like activity following UVB irradiation of human skin in vivo.
Using an in vivo skin chamber method, we demonstrated increased release of interleukin-1 (IL-1)-like activity at the site of irradiation with 3 times the minimal erythema dose of ultraviolet B (UVB). IL-1-like activity was estimated using the mouse thymocyte amplification assay. UVB-augmented release of IL-1-like activity peaked 1 h after irradiation and levels returned to baseline by 2 h. Release of IL-1-like activity from human skin after exposure to UV radiation may account for some of the local and systemic features of the sunburn response.
Murphy
G M
GM
Institute of Dermatology, St Thomas' Hospital, London, United Kingdom.
Dowd
P M
PM
Hudspith
B N
BN
Brostoff
J
J
Greaves
M W
MW
D000328:Adult; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D012867:Skin / Q000528:radiation effects*; D013471:Sunburn / Q000209:etiology*; D013997:Time Factors; D014466:Ultraviolet Rays
D007375:Interleukin-1