title: Behavioral and electrophysiological effects of crustacean neurohormone on freely moving cats.
abstract: The behavior of freely moving cats was assessed in an observation chamber during prolonged periods of time. Four patterns of behavior were consistently scored during the mid-day period: a) exploration, b) attention, c) grooming and d) drowsiness. Intracerebroventricular injections of crustacean neurodepressing hormone (NDH) greatly extended the time spent in drowsiness. The threshold dose of NDH for this effect was 300 units. The effect was established a few minutes after the injections and lasted for several hours. During this time the animals sat quietly and showed complete or semicomplete closure of the eyelids. Conspicuous changes in brain electrical activity were also observed under NDH. At low doses, the predominant electrophysiological pattern matches the activity recorded under spontaneous lapses of drowsiness, i.e., spindle bursts in trains of 8-16 Hz in cortical areas and mesencephalic reticular formation. At higher doses, the brain electrical activity changes into a nonconvulsive spiking activity in limbic areas. The time course of the effects differs in the various structures recorded. These results suggest a multiple substrate of NDH activity.
authors.affiliation: Laboratorio de Neurofisiología, CIRA Universidad Autónoma de Tlaxcala, México.
authors.forename: M
authors.initials: M
authors.lastname: Martínez-Gómez
authors.forename: P
authors.initials: P
authors.lastname: Pacheco
authors.forename: H
authors.initials: H
authors.lastname: Aréchiga
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D004594:Electrophysiology; D006728:Hormones / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009930:Organic Chemicals; D013997:Time Factors
chemical_list: D006728:Hormones; D009930:Organic Chemicals; C020425:neurodepressing hormone