Induction of early abortion with mifepristone (RU486) and two different doses of prostaglandin pessary (gemeprost).
One-hundred-and-twenty women of less than 56 days amenorrhoea were treated with a single dose of 600 mg of mifepristone in combination with half or a whole 1 mg gemeprost vaginal pessary. Complete abortion was induced in 119 (99%) women and there were no continuing pregnancies. There were few gastro-intestinal side effects following prostaglandin. The smaller dose of prostaglandin caused significantly less severe pain. This study confirmed the effectiveness of mifepristone and prostaglandin for the induction of early abortion but suggests that more research should be carried out to determine the lowest effective doses of both drugs.
Rodger
M W
MW
University of Edinburgh, Department of Obstetrics & Gynaecology, U.K.
Logan
A F
AF
Baird
D T
DT
D000019:Abortifacient Agents / Q000008:administration & dosage*; D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage*; D000028:Abortion, Induced / Q000009:adverse effects; D000032:Abortion, Therapeutic / Q000009:adverse effects; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006063:Chorionic Gonadotropin / Q000097:blood; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004963:Estrenes / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D015735:Mifepristone; D010570:Pessaries; D011247:Pregnancy; D011897:Random Allocation
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D006063:Chorionic Gonadotropin; D004963:Estrenes; D015735:Mifepristone; C021182:gemeprost; D000527:Alprostadil