Factors involved in the regulation of hematopoiesis.
With recombinant deoxyribonucleic acid (DNA) technology and better cell separation techniques, it is possible to demonstrate individual factor activity in the development of uncommitted and committed stem cells and their differentiation into functional mature cells. Much remains to be learned about the individual cell membrane receptors and their interactions with the polypeptide cytokines, as well as with other small molecules such as hemin. Some membrane perturbations must lead to complex and wonderful intracellular machinations to set in motion DNA and ribonucleic acid (RNA) changes leading to cell division and cell differentiation.
Morse
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Department of Laboratory Medicine, University of Connecticut Health Center, Farmington 06032.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D004274:DNA, Recombinant; D006133:Growth Substances / Q000502:physiology*; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D007378:Interleukins / Q000502:physiology
D004274:DNA, Recombinant; D006133:Growth Substances; D007378:Interleukins