[The role of muscarinic cholinoreceptors in regulating cellular functional activity].
The modern concepts of the molecular mechanisms of the coupling of muscarinic receptors (m-ChR) with biochemical systems of effector cells are reviewed. The problem of m-ChR heterogeneity and a possible role of phosphoinositide and cyclase systems of "second messengers" generation in the mediation of the effects of agonists on m-ChR are discussed. Particular emphasis is given to the role of N-proteins in the regulation of the coupling of different m-Chr subtypes with the effector mechanisms.
Dolgo-Saburov
V B
VB
D000818:Animals; D002468:Cell Physiological Phenomena; D002477:Cells / Q000187:drug effects; D004347:Drug Interactions; D008024:Ligands; D046911:Macromolecular Substances; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*; D015290:Second Messenger Systems / Q000187:drug effects
D008024:Ligands; D046911:Macromolecular Substances; D011976:Receptors, Muscarinic
Rol' muskarinovykh kholinoretseptorov v reguliatsii funktsional'noĭ aktivnosti kletki.