Neonatal therapeutic drug monitoring--its clinical relevance.
The potential clinical usefulness of therapeutic drug monitoring (TDM) in neonates is discussed. The personnel performing neonatal TDM must be knowledgeable in the many clinical, analytical, and pharmacokinetic variables used for measuring drug concentrations to formulate rational, individualized dosing regimens. Examples of variables and their effects on TDM interpretations are given and some gaps in our knowledge are presented. The theoretical promise of neonatal TDM is contrasted with the practical realities.
Walson
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PD
Division of Clinical Pharmacology/Toxicology, Ohio State University, Columbus 43205.
Edwards
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R
Cox
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S
D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D008991:Monitoring, Physiologic; D004364:Pharmaceutical Preparations / Q000097:blood*; D010599:Pharmacokinetics
D004364:Pharmaceutical Preparations