NSAIDs-induced asthma: peculiarities related to background and association with other drug or non-drugs etiological agents.
Drug-induced bronchial asthma appears in author's records from a group of 781 asthmatics in 10.5% (83 patients). Among them NSAIDs show a rate of incidence of 78% with 54% of the sample group with the Asthmatic Triad (AT). In virtually all cases (except for 3 cases with asthma induced exclusively by NSAIDs), NSAIDs induced asthmatic accident appears against the background of an established intrinsic (IA) or allergic asthma (AA) with some cases of triple etiological association: intrinsic + allergic (to pneumallergens or drugs) + NSAIDs-induced asthma. The association of NSAIDs-induced asthma with an atopic background (in author's records: 20 cases accounting for 45% of the sample group) impart an additional degree of seriousness to the AT. At the same time, however, these new forms provide reason for hope to prevent corticodependence or overcome it by resorting to pathogenic antiallergic medications (DSCG and Ketotifen). Among the drug related triggering factors, psychic stress plays an important part in relation to other etiological forms of asthma.
Iamandescu
I B
IB
Allergology Centre, Bucharest, Rumania.
D000485:Allergens / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D001249:Asthma / Q000139:chemically induced* / Q000453:epidemiology / Q000276:immunology; D015331:Cohort Studies; D004198:Disease Susceptibility; D004342:Drug Hypersensitivity / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D004347:Drug Interactions; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications; D012383:Romania / Q000453:epidemiology; D013315:Stress, Psychological / Q000150:complications
D000485:Allergens; D000894:Anti-Inflammatory Agents, Non-Steroidal