title: Timolol-pilocarpine combined vs timolol and pilocarpine given separately.
abstract: In a controlled, double-observer, multicenter study, we compared the effect of a fixed combination of timolol 0.5%-pilocarpine 4% twice a day with that of timolol 0.5% twice a day plus pilocarpine 4% three times a day in 80 patients with open-angle glaucoma whose intraocular pressure was greater than 21 mm Hg on timolol 0.5% twice a day alone. Administered twice daily, the combination drug lowered intraocular pressure as effectively as concomitant treatment with timolol twice a day and pilocarpine three times a day. No statistically significant differences in reduction of intraocular pressure were found between the two groups nor were any unexpected side effects observed.
authors.affiliation: Department of Ophthalmology, Huddinge University Hospital, Sweden.
authors.forename: M B
authors.initials: MB
authors.lastname: Söderström
authors.forename: O
authors.initials: O
authors.lastname: Wallin
authors.forename: P A
authors.initials: PA
authors.lastname: Granström
authors.forename: W
authors.initials: W
authors.lastname: Thorburn
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D015337:Multicenter Studies as Topic; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage* / Q000009:adverse effects; D011674:Pulse / Q000187:drug effects; D011897:Random Allocation; D013548:Sweden; D013997:Time Factors; D013999:Timolol / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D009883:Ophthalmic Solutions; D010862:Pilocarpine; D013999:Timolol