Living related donor kidney grafts in the cyclosporine era.
The results of 120 LRD kidney grafts, 49 HLA identical and 71 haploidentical, performed between 1981 and 1987 during the CyA era have been analyzed. The reduction in the incidence of rejection in diploidenticals with CyA vs AZA did not increase short- or long-term graft survival but was accompanied by worse kidney function and a greater need for antihypertensives. CyA did improve the results in haploidentical recipients over our historical experience, although prior sensitization was still a major hazard in this group.
MacDonald
A S
AS
Transplant Service, Dalhousie University, Halifax, Nova Scotia, Canada.
Belitsky
P
P
Bitter-Suermann
H
H
Cohen
A
A
Crocker
J
J
Ogborn
M
M
D000293:Adolescent; D000328:Adult; D003524:Cyclosporins / Q000627:therapeutic use*; D005190:Family; D005500:Follow-Up Studies; D006085:Graft Survival / Q000187:drug effects; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality; D014019:Tissue Donors
D003524:Cyclosporins