[Preoperative irradiation before enucleation in malignant melanoma of the uvea. Review of the literature and initial personal experiences].
The results of animal experiments and clinical studies concerning preoperative radiation of malignant extraocular tumors suggest that pre-enucleation radiation may be helpful in reducing the incidence of tumor-related death after enucleation of an eye containing a melanoma. Based on a retrospective study of 80 patients with malignant melanomas of the choroid or ciliary body, in which pre-enucleation irradiation with 8.5 Gray or 20 Gray was performed, no beneficial effect could be found in terms of better survival. The need for a prospective, randomized and possibly multicentered study is emphasized.
Bornfeld
N
N
Zentrum für Augenheilkunde, Medizinische Einrichtungen der Universität, Essen.
Huser
U
U
Sauerwein
W
W
Wessing
A
A
Sack
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002830:Choroid Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D002924:Ciliary Body / Q000528:radiation effects* / Q000601:surgery; D003131:Combined Modality Therapy; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000532:radiotherapy* / Q000601:surgery; D008875:Middle Aged; D011879:Radiotherapy Dosage; D014604:Uveal Neoplasms / Q000532:radiotherapy* / Q000601:surgery
Präoperative Bestrahlung vor Enukleation bei malignem Melanom der Uvea. Literaturübersicht und erste eigene Erfahrungen.