The effect of diphenylhydantoin on the electroretinogram.
Acute administration of diphenylhydantoin (DPH) in rabbits produces a significant increase in the amplitude of the a-wave. A marked increase in the amplitude of the b-wave is also noted but the time course is slower than that for the a-wave. While in controls the oscillatory potential (OP) recordings essentially consist of three major types, recordings taken after DPH injection consist of one major OP (OP2), which appears to be a result of the fusion of the original OP2 with another OP produced by the DPH injection. A similar blend of OPs was also seen in ERGs recorded from three human subjects on DPH therapy.
Lachapelle
P
P
Department of Ophthalmology, McGill University, Montreal, Quebec, Canada.
Blain
L
L
Quigley
M G
MG
Polomeno
R C
RC
Molotchnikoff
S
S
D000293:Adolescent; D000818:Animals; D003623:Dark Adaptation; D004596:Electroretinography / Q000187:drug effects; D006801:Humans; D008297:Male; D009991:Oscillometry; D010672:Phenytoin / Q000494:pharmacology*; D010775:Photic Stimulation; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000502:physiology
D010672:Phenytoin