title: Effects of fusidic acid on staphylococcal keratitis.
abstract: We treated 20 consecutive patients suffering from staphylococcal keratitis with topical fusidic acid 1% suspension in a carbomer gel. Fifteen (79%) of the isolated Staphylococcus epidermidis strains were resistant to methicillin, but all were sensitive to fusidic acid by in-vitro testing. The keratitis showed evidence of healing in 17 (85%) of the 20 patients. The healing times ranged between 5 and 21 days (mean 10.5 days). In this open clinical trial fusidic acid proved to be a safe and effective antibiotic for the treatment of staphylococcal keratitis.
authors.affiliation: King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: K F
authors.initials: KF
authors.lastname: Tabbara
authors.forename: S
authors.initials: S
authors.lastname: Antonios
authors.forename: H
authors.initials: H
authors.lastname: Alvarez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002986:Clinical Trials as Topic; D005260:Female; D005672:Fusidic Acid / Q000627:therapeutic use*; D006801:Humans; D007634:Keratitis / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013212:Staphylococcus epidermidis / Q000187:drug effects; D014792:Visual Acuity
chemical_list: D005672:Fusidic Acid