L-671,329, a new antifungal agent. I. Fermentation and isolation.
In screening for new antifungal agents from fungi, a new lipopeptide antifungal agent, L-671,329, similar to echinocandin B, has been isolated from Zalerion arboricola. Studies indicate that L-671,329 is produced under both solid and liquid fermentation conditions.
Schwartz
R E
RE
Merck Sharp & Dohme Research Laboratories, Rahway, N.J. 07065-0900.
Giacobbe
R A
RA
Bland
J A
JA
Monaghan
R L
RL
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D002851:Chromatography, High Pressure Liquid; D054714:Echinocandins; D005285:Fermentation; D010455:Peptides; D010456:Peptides, Cyclic / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054714:Echinocandins; D010455:Peptides; D010456:Peptides, Cyclic; C058995:pneumocandin A(0)