title: Plasma apolipoprotein H (beta 2-glycoprotein I) phenotype frequencies in a Japanese population.
abstract: We determined plasma apolipoprotein H (beta 2-glycoprotein I) levels in 300 healthy adult individuals and evaluated the frequencies of the BgN and BgD alleles in a Japanese population. These results were then compared with the previous reports. The plasma apo H levels in the subjects showed bimodal distribution: 274 subjects were in the range 15.6-33.2 mg/dl and were considered to be homozygous for BgN (phenotype NN), and 26 subjects were found in the range 9.6-14.8 mg/dl and were presumably heterozygous for BgN and BgD (phenotype ND). In this study, no sample below 5 mg/dl (phenotype DD) was found. Mean plasma apo H levels in NN and ND groups were 22.1 +/- 1.6 mg/dl and 12.5 +/- 1.6 mg/dl, respectively. The gene frequencies of BgN and BgD in a Japanese population were 0.957 and 0.043, respectively. These results were similar to gene frequencies of BgN and BgD in Caucasoids.
authors.forename: K
authors.initials: K
authors.lastname: Takamatsu
authors.forename: W
authors.initials: W
authors.lastname: Kishino
authors.forename: T
authors.initials: T
authors.lastname: Suehiro
authors.forename: T
authors.initials: T
authors.lastname: Yamano
authors.forename: F
authors.initials: F
authors.lastname: Ohno
mesh_terms: D005787:Gene Frequency / Q000235:genetics*; D006023:Glycoproteins / Q000097:blood / Q000235:genetics*; D006801:Humans; D007564:Japan; D010641:Phenotype; D053482:beta 2-Glycoprotein I
chemical_list: D006023:Glycoproteins; D053482:beta 2-Glycoprotein I