Site of influx of inflammatory white cells into a rejecting rat renal allograft.
In this paper we demonstrate that the vascular endothelium of a normal kidney and a syngeneic kidney graft binds only poorly syngeneic or allogeneic lymphocytes in an in vitro binding assay. On the contrary, the peritubular capillary endothelium of an allograft binds almost 7 times more lymphocytes than the peritubular capillary of a normal kidney. These findings suggest that the site of influx of inflammatory capillary white cells into the graft during rejection is the peritubular capillary endothelium.
Renkonen
R
R
Transplantation Laboratory, University of Helsinki, Finland.
Turunen
J P
JP
Häyry
P
P
D000818:Animals; D002196:Capillaries / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology*; D006084:Graft Rejection; D007249:Inflammation / Q000473:pathology; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation; D008214:Lymphocytes / Q000145:classification / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D014184:Transplantation, Homologous