title: Ten-year results of a randomized trial comparing a conservative treatment to mastectomy in early breast cancer.
abstract: A randomized trial was conducted at the Institut Gustave-Roussy (IGR) between 1972 and 1980 comparing tumorectomy and breast irradiation with modified radical mastectomy. One hundred and seventy-nine patients with an infiltrating breast carcinoma up to 20 mm in diameter at macroscopic examination were included: 88 had conservative management, and 91 a mastectomy. All patients had a low-axillary dissection with immediate histological examination. For the patients with positive axillary nodes, a complete axillary dissection was undertaken. Overall survival, distant metastasis, contralateral breast cancer and locoregional recurrence rates were not significantly different between the two treatment groups.
authors.affiliation: Institut Gustave-Roussy, Villejuif, France.
authors.forename: D
authors.initials: D
authors.lastname: Sarrazin
authors.forename: M G
authors.initials: MG
authors.lastname: Lê
authors.forename: R
authors.initials: R
authors.lastname: Arriagada
authors.forename: G
authors.initials: G
authors.lastname: Contesso
authors.forename: F
authors.initials: F
authors.lastname: Fontaine
authors.forename: M
authors.initials: M
authors.lastname: Spielmann
authors.forename: F
authors.initials: F
authors.lastname: Rochard
authors.forename: T
authors.initials: T
authors.lastname: Le Chevalier
authors.forename: J
authors.initials: J
authors.lastname: Lacour
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015411:Mastectomy, Modified Radical; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011897:Random Allocation