Early systemic effects on the hepatic mitochondria of tumour bearing mice.
The activities of citrate synthase and cytochrome c oxidase, mitochondrial marker enzymes, were evaluated in the liver of Ehrlich ascites carcinoma-bearing mice during the life span of the inoculated animals. After 10 days of tumour transplantation, when cell proliferation has ceased, a 30-40% decrease of these activities was detected in both liver and kidney. Simultaneously, an increase in the total acidic proteinase activity (50-60%) was observed. The gel filtration profiles of liver proteinase activities from inoculated animal extracts displayed different patterns to those of the controls; low molecular weight proteinase activities appear to be enhanced in the livers of tumour-bearing animals.
Urdiales
J L
JL
Departamento de Bioquímica, Biología Molecular y Química Orgánica, Facultad de Ciencias, Universidad de Málaga, Spain.
Medina
M A
MA
Núñez de Castro
I
I
Sánchez-Jiménez
F
F
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D010450:Endopeptidases / Q000032:analysis; D005260:Female; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D051379:Mice; D008930:Mitochondria, Liver / Q000378:metabolism*; D009368:Neoplasm Transplantation; D011506:Proteins / Q000378:metabolism
D011506:Proteins; D010450:Endopeptidases