title: Latest state of research on lactitol and dental caries.
abstract: Research on the dental properties of lactitol as a bulk sweetener to replace dietary sugar is reviewed under three headings: microbiological experiments in vitro, investigations in laboratory animals, and studies in man. Lactitol was not easily metabolized by acidogenic and polysaccharide-forming oral micro-organisms, its enamel-demineralizing potential in vitro intra-oral acid development and dental plaque formation from lactitol in man were substantially lower than from sucrose. The indications for dental health benefits are promising.
authors.affiliation: Department of Oral Medicine and Pathology, United Medical School, Guy's Hospital, London Bridge, London, UK.
authors.forename: T H
authors.initials: TH
authors.lastname: Grenby
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism; D002327:Cariostatic Agents; D003731:Dental Caries / Q000517:prevention & control*; D006801:Humans; D066298:In Vitro Techniques; D013402:Sugar Alcohols / Q000378:metabolism / Q000627:therapeutic use*; D013549:Sweetening Agents / Q000627:therapeutic use*
chemical_list: D002327:Cariostatic Agents; D013402:Sugar Alcohols; D013549:Sweetening Agents; C014635:lactitol