[Breakdown of the blood-retino-vitreal barrier after photocoagulation].
The degree of breakdown of the blood-retino-vitreal barrier after Argon laser photocoagulation, and the possibility of preventing it by topical or oral administration of indomethacin, have been investigated in a study involving 58 eyes of 29 rabbits. Protein levels in the vitreous, as determined by densitometry, were four times higher in photocoagulated than in non-photocoagulated eyes (p less than 0.005). Neither topical nor oral administration of indomethacin was successful in preventing post-photocoagulation breakdown of the blood-retino-vitreal barrier at the dosages employed.
Fandiño Fernandez
J M
JM
Fernandez-Vigo
J
J
Sandez
J
J
Carracedo
A
A
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D001813:Blood-Retinal Barrier; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D008028:Light Coagulation / Q000009:adverse effects*; D011506:Proteins / Q000032:analysis; D011817:Rabbits; D014822:Vitreous Body / Q000032:analysis / Q000293:injuries*
D011506:Proteins; D007213:Indomethacin
Rupture de la barrière hémato-rétino-vitréenne après photocoagulation.