[The chemical modification of immunoglobulins for accelerating their elimination from the blood flow during radioimmunodiagnosis].
Immunoglobulins were modified by diethylenetriaminepentaacetic acid anhydride and sulfosuccinimidy 16-(biotinamido) hexanoate and were conjugated with modified polylysine. Biodistribution of the samples was observed before and after avidin injection. Samples containing no polylysine accumulate in reticuloendothelial system, protein conjugate with polylysine concentrate in kidneys. The results demonstrate that drug distribution depends on the type of modification.
Mukhamedova
N M
NM
Obukhov
S K
SK
Slinkin
M A
MA
Klibanov
A L
AL
Torchilin
V P
VP
D000912:Antibodies, Neoplasm / Q000032:analysis; D000918:Antibody Specificity / Q000276:immunology; D001360:Avidin; D001710:Biotin; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis / Q000302:isolation & purification*; D009369:Neoplasms / Q000175:diagnosis; D011863:Radioimmunoassay / Q000379:methods*
D000912:Antibodies, Neoplasm; D007136:Immunoglobulins; D001360:Avidin; D001710:Biotin
Khimicheskaia modifikatsiia immunoglobulinov dlia uskoreniia ikh vyvedeniia iz krovotoka v protsesse radioimmunodiagnostiki.