title: Inducing factors and the control of mesodermal pattern in Xenopus laevis.
abstract: The mesoderm of Xenopus laevis and other amphibia is formed through an inductive interaction during which cells of the vegetal hemisphere act on cells of the animal hemisphere. Two groups of factors mimic the effects of the vegetal hemisphere. One group consists of members of the fibroblast growth factor (FGF) family, while the other is related to transforming growth factor type beta (TGF-beta). In this paper we discuss the evidence that the FGF family represents 'ventral' mesoderm-inducing signals, and the TGF-beta family 'dorsal' signals. The evidence includes a discussion of the cell types formed in response to each type of factor, the fact that only XTC-MIF (a member of the TGF-beta family) and not bFGF can induce animal pole ectoderm to become Spemann's organizer, and an analysis of the timing of the gastrulation movements induced by the factors.
authors.affiliation: Laboratory of Embryogenesis, National Institute for Medical Research, Ridgeway, Mill Hill, London, UK.
authors.forename: J C
authors.initials: JC
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Cooke
authors.forename: J B
authors.initials: JB
authors.lastname: Green
authors.forename: G
authors.initials: G
authors.lastname: Howes
authors.forename: K
authors.initials: K
authors.lastname: Symes
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004627:Embryonic Induction; D005346:Fibroblast Growth Factors / Q000502:physiology; D008648:Mesoderm / Q000502:physiology*; D015398:Signal Transduction; D015291:Transforming Growth Factors / Q000502:physiology; D014982:Xenopus laevis / Q000196:embryology*
chemical_list: D005346:Fibroblast Growth Factors; D015291:Transforming Growth Factors