title: Cyclosporin A: action and side-effects.
abstract: Cyclosporin A (CSA) is a new, potent immunosuppressive agent which is of proven value in organ transplantation. The use of CSA is associated with numerous side-effects, of which a dose-dependent nephrotoxicity is the most serious. CSA nephrotoxicity can be divided into two major groups: (i) functional toxicity without significant morphological lesions and (ii) morphological forms of toxicity with tubular and/or vascular-interstitial lesions. Vascular-interstitial toxicity is the most serious form because the renal lesions are irreversible.
authors.affiliation: Department of Pathology, University of Basel, Switzerland.
authors.forename: M J
authors.initials: MJ
authors.lastname: Mihatsch
authors.forename: G
authors.initials: G
authors.lastname: Thiel
authors.forename: B
authors.initials: B
authors.lastname: Ryffel
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D003524:Cyclosporins / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology
chemical_list: D003524:Cyclosporins