B-cell-mediated depression of the granulomatous response to BCG in mice.
The depression of the granulomatous response to Mycobacterium bovis strain BCG in mice infected intravenously with 2 x 10(7) CFU of the microorganism turned out to be mediated by various types of cells arising at different times after infection. Anti-PPD B lymphocytes were found to play a major role at Day 1 after infection and to be no longer effective 4 days later. At this time the depression was mediated by anti-idiotype B lymphocytes, whereas T lymphocytes proved to be involved in later phases of the infectious process. These results show that B lymphocytes may be of critical importance in the regulation of cell-mediated immune reactions to this facultative intracellular parasite.
Campa
M
M
Department of Biomedicine, University of Pisa, Italy.
Marelli
P
P
Ota
F
F
Zolfino
I
I
Senesi
S
S
Malvaldi
G
G
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D006099:Granuloma / Q000276:immunology*; D007108:Immune Tolerance; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009163:Mycobacterium bovis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D007130:Immunoglobulin Idiotypes