Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891.
The most efficient routes for the synthesis of FCE 22101, a penem antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891, its orally absorbed pro-drug, are described. On the basis of in-vitro antimicrobial profile and other characteristics the compounds have been considered worthy of further development.
Franceschi
G
G
Farmitalia Carlo Erba, Research and Development, Milan, Italy.
Perrone
E
E
Alpegiani
M
M
Bedeschi
A
A
Battistini
C
C
Zarini
F
F
Della Bruna
C
C
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D015780:Carbapenems; D055598:Chemical Phenomena; D002621:Chemistry; D007769:Lactams
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D007769:Lactams; C041561:FCE 22891; C040033:ritipenem