title: [Preoperative irradiation before enucleation in malignant melanoma of the uvea. Review of the literature and initial personal experiences].
abstract: The results of animal experiments and clinical studies concerning preoperative radiation of malignant extraocular tumors suggest that pre-enucleation radiation may be helpful in reducing the incidence of tumor-related death after enucleation of an eye containing a melanoma. Based on a retrospective study of 80 patients with malignant melanomas of the choroid or ciliary body, in which pre-enucleation irradiation with 8.5 Gray or 20 Gray was performed, no beneficial effect could be found in terms of better survival. The need for a prospective, randomized and possibly multicentered study is emphasized.
authors.affiliation: Zentrum für Augenheilkunde, Medizinische Einrichtungen der Universität, Essen.
authors.forename: N
authors.initials: N
authors.lastname: Bornfeld
authors.forename: U
authors.initials: U
authors.lastname: Huser
authors.forename: W
authors.initials: W
authors.lastname: Sauerwein
authors.forename: A
authors.initials: A
authors.lastname: Wessing
authors.forename: H
authors.initials: H
authors.lastname: Sack
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002830:Choroid Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D002924:Ciliary Body / Q000528:radiation effects* / Q000601:surgery; D003131:Combined Modality Therapy; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000532:radiotherapy* / Q000601:surgery; D008875:Middle Aged; D011879:Radiotherapy Dosage; D014604:Uveal Neoplasms / Q000532:radiotherapy* / Q000601:surgery
vernacular_title: Präoperative Bestrahlung vor Enukleation bei malignem Melanom der Uvea. Literaturübersicht und erste eigene Erfahrungen.