title: Pharmacokinetics of dactimicin in rats.
abstract: Dactimicin is a new pseudo-disaccharidic aminoglycosidic antibiotic produced by Dactylosporangium matsuzakiense. The aim of the present research was to evaluate the pharmacokinetics of dactimicin intramuscularly administered, at the dosage of 20 mg/kg, in male Sprague-Dawley rats with an average b.w. of 200-220 g. Dactimicin levels were assessed by using a microbiological method (agar diffusion) employing Bacillus subtilis ATCC 6633 as test organism. Samples were collected immediately before and 0.25, 0.50, 1, 1.15 and 2 h after drug administration. The mean peak serum level, reached after 15 min, was 33.6 micrograms/ml (range 30.3-40 micrograms/ml); T1/2 beta was 0.42 h; extrapolated AUC was 26.8 mg h/l.
authors.affiliation: Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Fraschini
authors.forename: F
authors.initials: F
authors.lastname: Scaglione
authors.forename: R
authors.initials: R
authors.lastname: Nebuloni
authors.forename: M
authors.initials: M
authors.lastname: Falchi
authors.forename: V
authors.initials: V
authors.lastname: Balsamo
authors.forename: G
authors.initials: G
authors.lastname: Cattaneo
mesh_terms: D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007273:Injections, Intramuscular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C023527:dactimicin