Sex-related canatoxin-induced blood glucose alterations in the rat.
1. The present study was designed to characterize sex-related canatoxin-induced blood glucose alterations in rats. 2. Chronic administration of canatoxin (50 mU, ip, daily for 3 days) induced hypoglycemia in female rats (N = 6) (-36.54 +/- 3.24%, P less than 0.05). The response of pregnant rats (N = 8) was similar to that observed for male rats (+29.57 +/- 4.70%). 3. Administration of canatoxin did not modify blood glucose levels of gonadectomized male or female rats. Similarly, pretreatment of intact male or female rats with human chorionic gonadotropin (40 IU/kg, im) blocked the effect of canatoxin on blood glucose levels. 4. Gonadal steroid replacement (testosterone, 10 mg/kg, im) for gonadectomized male rats did not reverse the inhibition of canatoxin-induced blood glucose alterations, whereas pretreatment of intact female rats (N = 6) with testosterone (10 mg/kg, im) significantly attenuated the canatoxin-induced hypoglycemia. 5. These data indicate that the blood glucose alterations produced by canatoxin in rats are under hormonal regulation.
Pires-Barbosa
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Departamento de Farmacologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Brasil.
Ribeiro-DaSilva
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G
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002369:Castration; D005260:Female; D037102:Lectins / Q000008:administration & dosage / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D010940:Plant Proteins; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics; D014118:Toxins, Biological
D001786:Blood Glucose; D037102:Lectins; D010940:Plant Proteins; D014118:Toxins, Biological; C032815:canatoxin