Effects of endothelin on regional hemodynamics in conscious rats.
Endothelin is a potent vasoactive peptide in anesthetized rats and isolated vascular smooth muscle. This study was performed to describe the hemodynamic effects of endothelin in conscious, freely moving rats. Endothelin (0.067-2 nmol/kg i.v.) produced long-lasting, dose-dependent increases in arterial pressure, mesenteric and, to a lesser degree, hindquarters vascular resistances and decreases in heart rate. We suggest that endothelin may play an important role in regulation of arterial pressure by modulating peripheral vasomotor tone.
Han
S P
SP
Department of Pharmacology, Saint Louis University School of Medicine, MO 63104.
Trapani
A J
AJ
Fok
K F
KF
Westfall
T C
TC
Knuepfer
M M
MM
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D016232:Endothelins; D006339:Heart Rate / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D009132:Muscles / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D016232:Endothelins; D010455:Peptides