Effect of nifedipine on renin-angiotensin-aldosterone system and renal prostaglandins in diabetic patients.
The present study investigated the short-term effect of calcium blocker nifedipine in 13 healthy subjects and in 13 patients with insulin-dependent diabetes mellitus. Nifedipine induced an increase in plasma renin activity in the control group, as well as in the diabetics. Plasma aldosterone did not change after nifedipine in either group. Urinary prostaglandin E2 and 6-keto prostaglandin F1 alpha increased significantly after nifedipine in the normal subjects. The diabetics showed a significant decrease of blood pressure without a concomitant change of the urinary prostaglandins. These findings suggest that the hypotensive effect of nifedipine in the diabetics is not mediated by prostaglandins.
Koev
D
D
Institute of Endocrinology and Gerontology, Christo Michailov, Sofia, Bulgaria.
Zacharieva
S
S
Tcharaktchiev
D
D
Borissova
A M
AM
Andonova
K
K
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D004573:Electrolytes / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology*; D011453:Prostaglandins / Q000652:urine*; D012016:Reference Values; D012084:Renin-Angiotensin System / Q000187:drug effects*
D004573:Electrolytes; D011453:Prostaglandins; D009543:Nifedipine