title: Involvement of prolyl endopeptidase in ascidian fertilization.
abstract: Inhibitory effects on fertilization of the ascidian of three benzyloxycarbonyl(Z)-aminoacyl prolinals and Z-Gly-Pro-chloromethyl ketone added before and after insemination were examined. The results suggest that the prolyl endopeptidase is involved in the process of fertilization, especially in a process taking place between chorion elevation and cell cleavage.
authors.affiliation: Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yokosawa
authors.forename: M
authors.initials: M
authors.lastname: Nishikata
authors.forename: S
authors.initials: S
authors.lastname: Ishii
mesh_terms: D000818:Animals; D002970:Cleavage Stage, Ovum / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology; D010450:Endopeptidases / Q000378:metabolism*; D005260:Female; D005306:Fertilization; D007700:Kinetics; D008297:Male; D000085822:Prolyl Oligopeptidases; D011480:Protease Inhibitors; D012697:Serine Endopeptidases; D014561:Urochordata / Q000201:enzymology*; D015053:Zygote / Q000187:drug effects
chemical_list: D004151:Dipeptides; D011480:Protease Inhibitors; C059348:N-benzyloxycarbonylalanylprolinal; C038541:N-benzyloxycarbonylprolylprolinal; C042268:N-benzyloxycarbonylvalylprolinal; D010450:Endopeptidases; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases; D003078:Colchicine