[The effect of blood serum components on the growth, biochemical and biological properties of streptococcus].
The components of cattle blood serum, added to the medium for the cultivation of group A streptococci, considerably decrease the period of adaptation and increase the balanced growth rate of streptococci, which is manifested by changes in the surface structures of the cell wall: the absence or modification of protein M. Streptococci grown under these conditions lose their capacity for phagocytosis, and from the cell walls obtained from these streptococci no surface protein M can be isolated by pepsin treatment. Nevertheless, the ratio of the main cell-wall components (proteins, polysaccharide and peptidoglycan), the amino acid composition, as well as the resistance of the cell walls to the action of trypsin and endo-N-acetylmuramidase are the same in M+ and Mx variants, that makes it possible to infer that the modification of protein M or the inhibition of its synthesis occurs during the growth of streptococci in the presence of blood serum components.
Savel'ev
E P
EP
Bitko
S A
SA
Dynga
L O
LO
Shmakova
Z F
ZF
Smirnova
M N
MN
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000276:immunology*; D001769:Blood; D002241:Carbohydrates / Q000032:analysis; D002352:Carrier Proteins; D002417:Cattle; D002473:Cell Wall / Q000276:immunology / Q000378:metabolism; D003470:Culture Media; D008970:Molecular Weight; D010587:Phagocytosis; D013297:Streptococcus pyogenes / Q000254:growth & development* / Q000276:immunology / Q000378:metabolism
D000596:Amino Acids; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002241:Carbohydrates; D002352:Carrier Proteins; D003470:Culture Media; C014689:streptococcal M protein
Vliianie komponentov syvorotki krovi na rost, biokhimicheskie i biologicheskie svoĭstva streptokokka.