title: [Lymphocyte subpopulations in multiple sclerosis (MS). A contribution].
abstract: The characterization of peripheral blood T-cell subpopulations in 29 multiple sclerosis (MS) patients is studied. A direct immunofluorescence assay was performed using monoclonal antibodies (OK series) directed to lymphocytes surface antigens. In transverse study, the patients suffering from progressive MS showed T4+ lymphocytes and T4+/T8+ ratio significantly high (p less than 0.05) compared to controls; furthermore T8+ lymphocyte values were low. T3+ lymphocytes were low (p less than 0.05) during the relapse in the MS remitting relapsing patients. A six month follow-up of the patients showed, during relapse, a reduction and, immediately after, a recovery of T3+ and T4+ lymphocyte values; T8+ lymphocytes didn't show remarkable fluctuations.
authors.affiliation: Università degli Studi di Chieti, Clinica Neurologica.
authors.forename: F
authors.initials: F
authors.lastname: Nuccetelli
authors.forename: M
authors.initials: M
authors.lastname: Assetta
authors.forename: A
authors.initials: A
authors.lastname: Tartaro
authors.forename: A
authors.initials: A
authors.lastname: Di Muzio
authors.forename: E
authors.initials: E
authors.lastname: Nanni Costa
authors.forename: M
authors.initials: M
authors.lastname: Anichini
authors.forename: D
authors.initials: D
authors.lastname: Gambi
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D002908:Chronic Disease; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology* / Q000628:therapy; D012008:Recurrence; D012074:Remission Induction; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal
vernacular_title: Le sottopopolazioni linfocitarie nella sclerosi multipla (SM). Un contributo.