title: Successful treatment of metastatic endophthalmitis. Case reports.
abstract: Endophthalmitis is a well-recognized complication of intraocular surgery, penetrating ocular trauma and systemic infection. Metastatic bacterial endophthalmitis is rare. However, once it happens, the visual outcome is very poor. In order to prevent visual damage, early diagnosis and treatment is essential. Due to the blood-ocular barrier, intravitreal drug concentrations are low after systemic administration. Strong antibiotics with good penetration into the vitrous humor are needed to obtain adequate bactericidal concentrations. We report two cases with liver abscess complicated by septic events to the eye. One was uveitis, and the other was endophthalmitis. They were diagnosed early and were successfully treated with parenteral ceftriaxone and good vision was preserved.
authors.affiliation: Department of Medicine, Veterans General Hospital, Taipei, Taiwan, Republic of China.
authors.forename: F D
authors.initials: FD
authors.lastname: Wang
authors.forename: L S
authors.initials: LS
authors.lastname: Wang
authors.forename: Y C
authors.initials: YC
authors.lastname: Liu
authors.forename: C Y
authors.initials: CY
authors.lastname: Liu
authors.forename: C L
authors.initials: CL
authors.lastname: Lin
authors.forename: W W
authors.initials: WW
authors.lastname: Wong
mesh_terms: D000328:Adult; D002443:Ceftriaxone / Q000627:therapeutic use; D009877:Endophthalmitis / Q000188:drug therapy / Q000209:etiology*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy*; D005451:Fluorescein Angiography; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy*; D008100:Liver Abscess / Q000150:complications*; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000175:diagnosis; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use; D014463:Ultrasonography; D014605:Uveitis / Q000188:drug therapy / Q000209:etiology; D014792:Visual Acuity
chemical_list: D002443:Ceftriaxone; D014295:Trimethoprim; D013420:Sulfamethoxazole