Anthracene-9-carboxylic acid and haematological and biochemical variables in the rat.
Chronic administration of anthracene-9-carboxylic acid in Long-Evans rats had no significant effect on the following haematological and biochemical variables: haemoglobin, haematocrit, serum sodium, potassium, glucose, cholesterol and proteins. In agreement with previous reports, significant age-related differences of glucose and cholesterol concentration were observed. A decrease of body weight was the main finding. The similarities between the myotonia induced by anthracene-9-carboxylic acid and the characteristic myotonic, haematological and biochemical alterations in patients with myotonia congenita, suggest that, despite untoward effects such as a decrease of body weight, chronic anthracene-9-carboxylic acid administration appears to be a good model for the study of mytonia congenita.
Villegas-Navarro
A
A
Unidad de Investigación Biomédica del Noreste, I.M.S.S., Monterrey, Nuevo León, Mexico, D.F.
Jiménez-Salas
Z
Z
Reyes
J L
JL
D000375:Aging / Q000502:physiology; D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D005260:Female; D008297:Male; D009222:Myotonia / Q000139:chemically induced / Q000503:physiopathology; D051381:Rats; D012737:Sex Factors
D000873:Anthracenes; D001786:Blood Glucose; C010030:9-anthroic acid; D002784:Cholesterol