Prolongation of heart allograft survival in course of donor specific antigen and alloserum treatment in the rat.
Different cell subpopulations involved in the induction of immune enhancement of the heart graft survival in rats differing across the major histocompatibility barrier has been studied. Cells devoid of class II antigens on their surface, e.g. erythrocytes, platelets, and thymocytes have been found ineffective, whereas subpopulations rich in class II antigens were found to be highly effective in induction of specific unresponsiveness when combined with donor specific alloserum. Our results suggest that class II antigens take part not only in induction of rejection response but may be also responsible for generation of specific unresponsiveness towards donor antigens.
Romaniuk
A
A
Department for Surgical Research and Transplantology, Polish Academy of Sciences, Warsaw.
Ryffa
T
T
Rowiński
W
W
Olszewski
W L
WL
D000818:Animals; D006085:Graft Survival / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007107:Immune System / Q000502:physiology*; D007116:Immunization, Passive; D008221:Lymphoid Tissue / Q000276:immunology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000949:Histocompatibility Antigens Class II