title: An alternative view of heparin anticoagulation in acute focal brain ischemia.
abstract: Despite the lack of evidence of its efficacy, heparin therapy has been recommended for selected patients with ischemic stroke syndromes. However, heparin has procoagulant effects on platelet function and a propensity to produce serious side effects. When these factors are considered, heparin loses its appeal as a therapeutic agent for patients with acute focal cerebral ischemia.
authors.affiliation: Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: S J
authors.initials: SJ
authors.lastname: Phillips
mesh_terms: D000208:Acute Disease; D000925:Anticoagulants / Q000627:therapeutic use; D001696:Biomechanical Phenomena; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy*; D002561:Cerebrovascular Disorders / Q000517:prevention & control; D006470:Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D006493:Heparin