title: Early recurrence in unipolar depression.
abstract: While some advances have occurred in the maintenance treatment of unipolar depression, empirical data on recurrences of illness following the discontinuation of medication are sparse. We examined survival time during the first 18 months after discontinuation of medication in 74 patients with recurrent unipolar depression. Although demographic characteristics, clinical characteristics, and pharmacologic treatment variables failed to predict time to recurrence, continued interpersonal psychotherapy was significantly related to longer survival time.
authors.affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA.
authors.forename: E
authors.initials: E
authors.lastname: Frank
authors.forename: D J
authors.initials: DJ
authors.lastname: Kupfer
authors.forename: J M
authors.initials: JM
authors.lastname: Perel
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy / Q000517:prevention & control* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D010043:Outcome and Process Assessment, Health Care; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D011613:Psychotherapy; D012008:Recurrence; D013997:Time Factors
chemical_list: D007099:Imipramine