The movement of blood formaldehyde in methanol intoxication. I. A simple headspace gas chromatography-mass spectrometry for determining the amount of formaldehyde in the blood.
A gas chromatographic-mass spectrometric method for determining the amount of formaldehyde in the blood has been investigated. This method is based on the formation of diethoxymethane, which results from the reaction of formaldehyde with ethanol while in an acid state. The calibration curve in blood specimens showed a good linearity in the range of 20 to 100 microM formaldehyde with a correlation coefficient of 0.996. The minimum detectable amount of formaldehyde in the blood was found to be 10 microM and this analytic method was deemed useful for microanalysis of formaldehyde in blood.
Matsumoto
K
K
Moriya
F
F
Nanikawa
R
R
D005557:Formaldehyde / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D000432:Methanol / Q000506:poisoning*; D014116:Toxicology
D005557:Formaldehyde; D000432:Methanol