title: Blood pressure and vasoactive hormones with improved glycaemic control in patients with diabetes mellitus.
abstract: To assess the effects of improved glycaemic control on arterial pressure and plasma levels of vasoactive hormones, we studied 5 male insulin dependent (Type 1) diabetic patients before and one month after commencement of rigorous control of blood glucose levels. On each occasion, continuous ambulatory intra arterial pressure monitoring for a 10-hour period, together with hourly venous sampling for plasma glucose and vasoactive hormone determinations, was performed under standardised conditions of diet and posture. Mean (+/- SEM) plasma glucose before and after improved glycaemic control was 9.4 +/- 0.3 and 6.6 +/- 0.4 mmol/l respectively (P less than 0.001). There was a small but significant fall in arterial pressure in each patient as well as for the group overall (mean arterial pressure fall 4.8 +/- 1.2 mmHg, p less than 0.01) after improved glycaemic control. The fall in individual (10 hr mean) diastolic arterial pressure levels correlated with concomitant falls in plasma glucose levels (r = 0.92, p less than 0.05) but not with changes in any of the other variables measured.
authors.affiliation: Department of Endocrinology, Princess Margaret Hospital, Christchurch, New Zealand.
authors.forename: A M
authors.initials: AM
authors.lastname: Richards
authors.forename: T
authors.initials: T
authors.lastname: Donnelly
authors.forename: M G
authors.initials: MG
authors.lastname: Nicholls
authors.forename: H
authors.initials: H
authors.lastname: Ikram
authors.forename: E J
authors.initials: EJ
authors.lastname: Hamilton
authors.forename: E A
authors.initials: EA
authors.lastname: Espiner
mesh_terms: D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects*; D003922:Diabetes Mellitus, Type 1 / Q000178:diet therapy / Q000628:therapy*; D004837:Epinephrine / Q000097:blood; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D009638:Norepinephrine / Q000097:blood; D012083:Renin / Q000097:blood
chemical_list: D001786:Blood Glucose; D000804:Angiotensin II; D000450:Aldosterone; D012083:Renin; D009638:Norepinephrine; D004837:Epinephrine