title: Clinical experience with ciprofloxacin: analysis of a multicenter study.
abstract: In a multicenter study of 128 patients treated with ciprofloxacin (mean daily dosage, 982 mg per day; mean duration of treatment, 8.9 days) for a variety of infections, 48 were microbiologically proven. Of these, bacteriologic cure and/or improvement resulted in 93% of cases. For all 128 infections clinical cure and/or improvement resulted in 93.8% of cases. Twenty-nine (23.8%) of all infections were classified as chronic. Overall, there were 3/128 (2.3%) adverse reactions (ADRs); one case each of diarrhea, malaise, and nausea/vomiting. None were related definitely to ciprofloxacin therapy. Therapy with ciprofloxacin was discontinued in two (1.6%) of 128 patients because of adverse gastrointestinal (GI) effects. One patient elected to continue ciprofloxacin therapy despite mild GI side effects.
authors.forename: J F
authors.initials: JF
authors.lastname: Simmons
authors.forename: C E
authors.initials: CE
authors.lastname: Cowley
authors.forename: D B
authors.initials: DB
authors.lastname: Dozier
authors.forename: A M
authors.initials: AM
authors.lastname: Galdini
authors.forename: M R
authors.initials: MR
authors.lastname: Manes
authors.forename: G H
authors.initials: GH
authors.lastname: Nungester
authors.forename: M T
authors.initials: MT
authors.lastname: Schreeder
authors.forename: K D
authors.initials: KD
authors.lastname: Strother
authors.forename: B W
authors.initials: BW
authors.lastname: Chun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000407:Alabama; D001424:Bacterial Infections / Q000188:drug therapy*; D002648:Child; D002939:Ciprofloxacin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic
chemical_list: D002939:Ciprofloxacin