Studies on penem antibiotics. II. In vitro activity of SUN5555, a new oral penem.
The new oral penem antibiotic SUN5555 shows broad antibacterial activity against both aerobic and anaerobic Gram-positive and Gram-negative bacteria. SUN5555 is highly stable against various beta-lactamases. It binds preferentially to the penicillin-binding proteins 2 and 1A of Escherichia coli.
Nishino
T
T
Department of Microbiology, Kyoto Pharmaceutical University, Japan.
Maeda
Y
Y
Ohtsu
E
E
Koizuka
S
S
Nishihara
T
T
Adachi
H
H
Okamoto
K
K
Ishiguro
M
M
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001426:Bacterial Proteins; D015780:Carbapenems; D002352:Carrier Proteins / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D006602:Hexosyltransferases; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007769:Lactams; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism; D046915:Penicillin-Binding Proteins; D010406:Penicillins / Q000378:metabolism; D010458:Peptidyl Transferases; D011485:Protein Binding
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D002352:Carrier Proteins; D007769:Lactams; D046915:Penicillin-Binding Proteins; D010406:Penicillins; C060114:SUN 5555; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase