title: Duodenal gangliocytic paraganglioma with lymph node metastasis in a 17-year-old boy.
abstract: A case of duodenal gangliocytic paraganglioma (DGP) in a 17-year-old boy is presented. In this case a lymph node in the peripancreatic region was involved by a metastatic tumor. A review of the literature on DGP indicates that this case represents the youngest patient and is the second case of DGP with metastasis. Immunohistochemical staining for neuron-specific enolase (NSE), neurofilament (NF), pancreatic polypeptide, and somatostatin showed positive results for epithelioid and ganglion-like cells, whereas spindle cells showed immunoreactivities for S-100 protein, NSE, and NF. The histogenesis of DGP is discussed.
authors.affiliation: Department of Pathology, Hiroshima University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Inai
authors.forename: T
authors.initials: T
authors.lastname: Kobuke
authors.forename: S
authors.initials: S
authors.lastname: Yonehara
authors.forename: S
authors.initials: S
authors.lastname: Tokuoka
mesh_terms: D000293:Adolescent; D004379:Duodenal Neoplasms / Q000032:analysis / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D009454:Neurofibrils / Q000032:analysis; D010191:Pancreatic Polypeptide / Q000032:analysis; D010235:Paraganglioma / Q000032:analysis / Q000473:pathology* / Q000556:secondary; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis
chemical_list: D009418:S100 Proteins; D010191:Pancreatic Polypeptide; D010751:Phosphopyruvate Hydratase