A multi-centre double-blind controlled trial of glucagon and insulin therapy for severe acute hepatitis.
A cooperative study was conducted to determine the efficacy of one week of treatment with infusion of 1 mg glucagon and 10 units insulin twice daily in severe acute hepatitis. Ninty-eight patients with either prothrombin time less than 60% or thrombotest or hepaplastin test less than 50% of normal were randomly assigned to hormone or placebo treatment. SGOT and SGPT values dropped after treatment with a gradual decrease or increase in total serum bilirubin or cholesterol levels similarly in both groups receiving hormone or placebo. Deranged prothrombin time improved more rapidly in the hormone group than in the placebo group. Glucagon and insulin infusion may stimulate recovery of the liver from injury.
Oka
H
H
First Department of Internal Medicine, University of Tokyo Faculty of Medicine, Japan.
Fujiwara
K
K
Okita
K
K
Ishii
H
H
Sakuma
A
A
D000208:Acute Disease; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005934:Glucagon / Q000627:therapeutic use*; D006525:Hepatitis, Viral, Human / Q000188:drug therapy*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D008111:Liver Function Tests; D008115:Liver Regeneration; D008297:Male; D015337:Multicenter Studies as Topic; D011517:Prothrombin Time; D011897:Random Allocation
D007328:Insulin; D005934:Glucagon