Vancomycin and ceftazidime in the treatment of CAPD peritonitis.
102 episodes of continuous ambulatory peritoneal dialysis (CAPD) peritonitis were studied prospectively during a 288-day period at The Queen Elizabeth Hospital, Birmingham. Organisms were isolated from 76% of the episodes, with coagulase-negative staphylococci, being the most commonly encountered organism (55%). Initial treatment consisted of intraperitoneal vancomycin and ceftazidime with subsequent adjustment on the basis of antibiotic sensitivities. With this regimen, 83% of the positive cultures became negative by 72 h, 9.8% of cases relapsed and removal of the CAPD catheter was necessary in 8 patients (7.8%). Overall, 92% of cases were cured. No adverse drug reactions were seen. This combination of antibiotics appears effective and safe in the treatment of CAPD peritonitis.
Beaman
M
M
Department of Nephrology, Queen Elizabeth Hospital, Birmingham, UK.
Solaro
L
L
McGonigle
R J
RJ
Michael
J
J
Adu
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D002442:Ceftazidime / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology; D014640:Vancomycin / Q000008:administration & dosage*
D014640:Vancomycin; D002442:Ceftazidime