title: [The incidence of the secondary failure of sulfonylurea therapy. Epidemiological research].
abstract: The proportion of secondarily insulin-dependent diabetics among all insulin-dependent diabetics and the incidence of secondary failures among all those receiving sulphonylurea preparations was determined for a defined region of Berlin (DDR). Among all diabetics receiving insulin, 40% were type I diabetics on primary insulin treatment. But the remaining 60% were secondary failures who had been on diet alone or in combination with oral antidiabetics. Among 3071 diabetics on glibenclamide secondary failures occurred in 5% per year. The ratio of primary to secondary insulin-receiving diabetics, between 1:5 and 1:6, defined the number of new insulin-dependent patients per year. The findings indicate that insulin-receiving diabetics constitute an epidemiologically heterogeneous patient group.
authors.affiliation: Zentralstelle für Diabetes und Stoffwechselkrankheiten, DDR-Berlin.
authors.forename: H
authors.initials: H
authors.lastname: Thoelke
authors.forename: K P
authors.initials: KP
authors.lastname: Ratzmann
mesh_terms: D000367:Age Factors; D001604:Berlin; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000453:epidemiology; D003927:Diet, Diabetic; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D014505:Urban Population
chemical_list: D007328:Insulin; D013453:Sulfonylurea Compounds
vernacular_title: Häufigkeit des Sekundärversagens einer Sulfonylharnstofftherapie. Epidemiologische Untersuchung.