title: Generalized sarcoidlike granulomas with systemic angiitis, crescentic glomerulonephritis, and pulmonary hemorrhage. Report of an autopsy case.
abstract: A 19-year-old woman showed rapidly progressive renal and respiratory failure and died after a short clinical course. The autopsy revealed that death was due to crescentic glomerulonephritis and pulmonary hemorrhage. The intrathoracic lymph nodes, lungs, kidneys, and other organs contained numerous epithelioid granulomas, some of which had foci of central coagulative necrosis. The aorta, its major branches, and small- to medium-sized vessels of various organs also had multiple areas of granulomatous angiitis. This is, to our knowledge, the first report of such autopsy findings. A discussion of the etiopathogenesis of the disease is presented.
authors.affiliation: Department of Pathology, Kansai Medical University, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shintaku
authors.forename: K
authors.initials: K
authors.lastname: Mase
authors.forename: H
authors.initials: H
authors.lastname: Ohtsuki
authors.forename: R
authors.initials: R
authors.lastname: Yasumizu
authors.forename: K
authors.initials: K
authors.lastname: Yasunaga
authors.forename: S
authors.initials: S
authors.lastname: Ikehara
mesh_terms: D000328:Adult; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology*; D006099:Granuloma / Q000473:pathology*; D006470:Hemorrhage / Q000473:pathology*; D006801:Humans; D008171:Lung Diseases / Q000473:pathology*; D012507:Sarcoidosis / Q000473:pathology*; D014657:Vasculitis / Q000473:pathology*