Changes in c-onc expression during embryonal carcinoma cell differentiation.
Protooncogenes expressed in murine embryonal carcinoma (EC) cells or their differentiated daughter cells include more or less ubiquitously expressed protooncogenes such as c-myc, c-K-ras, and c-abl, as well as c-onc genes with a very restricted expression pattern. Examples of the latter are N-myc, c-mos, and int-2. These c-onc genes are transcriptionally active in EC cells, as well as in germ cells and/or early embryonic cells. When EC cells are induced to differentiate some protooncogenes or oncogene-related products undergo changes in expression. Thus, EC cell differentiation has been associated with increased expression of c-src, c-fos, int-1, int-2, and the epidermal growth factor (EGF) receptor, whereas decreased expression has been observed for c-mos, c-K-ras, c-myc, N-myc, and platelet-derived growth factor. The relationships between these changes in expression and EC cell differentiation are not understood. They may be important for the differentiation process or for expression of a differentiated phenotype. They may, however, also be secondary events with no functional significance to EC cell differentiation.
Sejersen
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Department of Medical Cell Genetics, Karolinska Institutet, Stockholm, Sweden.
Jin
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Rahm
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Ringertz
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D000818:Animals; D002454:Cell Differentiation; D054278:Embryonal Carcinoma Stem Cells; D020558:GTP Phosphohydrolases / Q000235:genetics; D005786:Gene Expression Regulation; D006133:Growth Substances / Q000235:genetics; D066298:In Vitro Techniques; D051379:Mice; D014411:Neoplastic Stem Cells / Q000166:cytology*; D009687:Nuclear Proteins / Q000235:genetics; D011494:Protein Kinases / Q000235:genetics; D011519:Proto-Oncogenes
D006133:Growth Substances; D009687:Nuclear Proteins; D011494:Protein Kinases; D020558:GTP Phosphohydrolases