Interleukin 1 protects against the lethal effects of irradiation of mice but has no effect on tumors in the same animals.
Interleukin 1 (IL-1) is a radioprotector of bone marrow and is cytotoxic to some tumor cells. This investigation examines these two properties in the same host animals and gives evidence of radioprotection against localized x-irradiation of the head and neck region. By LD50 analyses, recombinant human IL-1 (100 ng/mouse, approximately 3 micrograms/kg) was found to be radioprotective against whole-body irradiation for both C3H/Km and C57BL/Ka mice. The combined potency ratio for the two strains was 1.07 (95% confidence limit: 1.02-1.12). It was also radioprotective against the injury leading to acute lethality resulting from localized head and neck irradiation of C3H/Km mice; 100 ng of IL-1/mouse produced a potency ratio of 1.05 (95 confidence limit: 1.03-1.07). However, two tumors that originated in C3H/Km mice, RIF-1 and SCCVII, showed neither in vitro nor in vivo response to IL-1. Also, there was no IL-1-induced reduction in in vivo growth of the RL 12NP lymphoma in C57BL/Ka mice.
Dorie
M J
MJ
Department of Radiation Oncology, Stanford University Medical Center, California 94305.
Allison
A C
AC
Zaghloul
M S
MS
Kallman
R F
RF
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D005354:Fibrosarcoma / Q000628:therapy; D006257:Head / Q000528:radiation effects; D007375:Interleukin-1 / Q000494:pharmacology* / Q000627:therapeutic use; D008223:Lymphoma / Q000188:drug therapy; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009333:Neck / Q000528:radiation effects; D009374:Neoplasms, Experimental / Q000628:therapy*; D011837:Radiation-Protective Agents; D011994:Recombinant Proteins / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014916:Whole-Body Irradiation
D007375:Interleukin-1; D011837:Radiation-Protective Agents; D011994:Recombinant Proteins