Maintenance therapy of cyclical mastalgia using low-dose danazol.
In an open study, low-dose danazol (mean total dose 700 mg/month) was given during the luteal phase to 20 women with severe relapsing cyclical mastalgia. All subjects had previously obtained a useful clinical response on conventional dosage of danazol, but side effects occurred in 13 (65%). On the low-dose regimen, complete relief of symptoms was attained by 11 women (55%) and the remainder achieved a substantial clinical improvement; no side effects were reported. A low-dose regimen may be suitable for women with chronic relapsing cyclical mastalgia or those who develop side effects on conventional dosage.
Harrison
B J
BJ
Maddox
P R
PR
Mansel
R E
RE
D000328:Adult; D001940:Breast; D002986:Clinical Trials as Topic; D003613:Danazol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008183:Luteal Phase; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D011245:Pregnadienes / Q000008:administration & dosage*; D012008:Recurrence
D011245:Pregnadienes; D003613:Danazol