[Effect of cisplatin on healthy human renal tubular cells and cancerous cells in culture].
An in vitro comparative cis-platin cytotoxicity was evidenced in human renal normal and tumoral cultured cells. Cytotoxic effect was estimated at membrane level by intracellular enzymatic markers release into culture medium and nuclear level by ADN synthesis inhibition after 3H thymidine incorporation. These results show a more intensive activity of cis-platin in normal tubular cells than in tumoral ones.
Merlet
D
D
Merlet
J P
JP
Cambar
J
J
D002478:Cells, Cultured; D002945:Cisplatin / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000648:ultrastructure; D007684:Kidney Tubules / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology
D004247:DNA; D002945:Cisplatin
Effet du cis-platine sur des cellules tubulaires rénales humaines saines et cancéreuses en culture.