title: [Diflucortolone-21-valerate Reference Standard (Control 871) of National Institute of Hygienic Sciences].
abstract: Diflucortolone-21-valerate was tested for the preparation of "Diflucortolone-21-valerate Reference Standard (Control 871)". Analytical data obtained were as follows: loss on drying, 0.05%; infrared spectrum, 1745, 1727, 1667, 1625, 1611, 1169 cm-1; ultraviolet spectrum, lambda max = 239 nm; absorbance, E1%1cm (239 nm) = 348.8; optical rotation, [alpha]20D: + 100.8 degrees; melting point, 203.2 degrees C; thin-layer chromatography, three contaminants were detected; high-performance liquid chromatography, two contaminants were detected; fluorine, 8.06%. On the basis of those results, this material was authorized as the National Institute of Hygienic Sciences Reference Standard (Control 871).
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: R
authors.initials: R
authors.lastname: Hiroshige
authors.forename: M
authors.initials: M
authors.lastname: Murai
authors.forename: H
authors.initials: H
authors.lastname: Tokunaga
authors.forename: S
authors.initials: S
authors.lastname: Okada
authors.forename: T
authors.initials: T
authors.lastname: Kimura
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004060:Diflucortolone / Q000031:analogs & derivatives* / Q000032:analysis / Q000592:standards; D004340:Drug Contamination; D005448:Fluocortolone / Q000031:analogs & derivatives*; D007564:Japan; D010602:Pharmacopoeias as Topic / Q000592:standards*; D012015:Reference Standards; D013055:Spectrophotometry, Infrared
chemical_list: C013486:diflucortolone valerate; D005448:Fluocortolone; D004060:Diflucortolone