Vacor inhibits insulin release from islets in vitro.
It has been reported that Vacor, a rodenticide containing N-3-pyridylmethyl-N'-p-nitrophenyl urea, causes insulin-dependent diabetes mellitus. The pathomechanism of Vacor-induced diabetes mellitus has not been clarified yet. The effect of Vacor, therefore, was studied in terms of insulin release from isolated rat pancreatic islets. Vacor suppressed glucose-stimulated insulin release, but did not affect the insulin release induced by theophylline or 12-o-tetra-decanoylphorbol 13-acetate. It is suspected that the suppression of insulin release from pancreatic islets by Vacor may contribute to the pathogenesis of Vacor-induced diabetes mellitus and that this suppression might not be related to cAMP and C-kinase.
Taniguchi
H
H
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Yamashiro
Y
Y
Chung
M Y
MY
Hara
Y
Y
Ishihara
K
K
Ejiri
K
K
Baba
S
S
D000818:Animals; D005947:Glucose / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D010671:Phenylurea Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012378:Rodenticides / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology
D007328:Insulin; D010671:Phenylurea Compounds; D012378:Rodenticides; D013806:Theophylline; D005947:Glucose; C012598:pyriminil