[A new method of bone sterilization].
Bone transplantation is associated with two major problems: the sterility in particular with respect to HIV, and the osteoinductivity of the transplant. We describe a procedure which sterilizes the graft while keeping the osteoinductive potential of the bone. After harvesting the material the bone is immediately deep frozen (-80 degrees C), and then freeze dried. To sterilize the bone it is treated with gamma-radiation at a dose of 2.5 Mrad in an argon atmosphere. All grafts are subsequently stored in argon at -80 degrees C.
Jerosch
J
J
Preisendanz
H
H
Krumschmidt
H
H
Castro
W H
WH
D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control; D016025:Bone Transplantation; D001842:Bone and Bones / Q000528:radiation effects; D005615:Freezing; D006678:HIV / Q000528:radiation effects; D006801:Humans; D013242:Sterilization / Q000295:instrumentation*; D014021:Tissue Preservation / Q000295:instrumentation*
Eine neue Methode der Knochensterilisation.