title: A double-blind study of hyposensitization with an alginate conjugated extract of D. pteronyssinus (Conjuvac) in patients with perennial rhinitis. 1. Clinical aspects.
abstract: The efficacy of hyposensitization with a standardised extract of Dermatophagoides pteronyssinus (D. pteronyssinus) conjugated to alginate and containing known amounts of antigen P1 (Conjuvac) was tested in a double blind, placebo controlled, multi-centre study in 66 adult patients with perennial rhinitis. Patients received 11 weekly injections of increasing concentrations of Conjuvac containing from 56 x 10(1) to 448 10(3) IU D. pteronyssinus or placebo injections of the alginate diluent to some of which 5 micrograms of histamine has been randomly added. This was followed by 15 monthly injections of Conjuvac or placebo. The severity of nasal blockage, sneezing and rhinorrhoea was recorded twice daily in a diary and visual analogue assessments (VAS) made at each clinic visit. Nasal provocation testing (NPT) was performed with increasing concentrations of the same extract of D. pteronyssinus as used in the hyposensitization injections, and changes in nasal airways resistance measured by passive anterior rhinomanometry. VAS was recorded and NPT was performed on entry to the study and after the fifth, ninth and final monthly injection. Conjuvac injections were well tolerated. Large local reactions (greater than 5 cm) occurred within 30 min in only 1% of patients but later in 23%. No systemic reactions or anaphylaxis occurred within 30 min of injections, but urticaria or worsening of asthma and rhinitis was reported later in 3% of patients.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Academic Department of Respiratory Medicine, St Bartholomew's Hospital, London, U.K.
authors.forename: O J
authors.initials: OJ
authors.lastname: Corrado
authors.forename: E
authors.initials: E
authors.lastname: Pastorello
authors.forename: S
authors.initials: S
authors.lastname: Ollier
authors.forename: L
authors.initials: L
authors.lastname: Cresswell
authors.forename: C
authors.initials: C
authors.lastname: Zanussi
authors.forename: C
authors.initials: C
authors.lastname: Ortolani
authors.forename: A
authors.initials: A
authors.lastname: Incorvaia
authors.forename: A
authors.initials: A
authors.lastname: Fugazza
authors.forename: J R
authors.initials: JR
authors.lastname: Lovely
authors.forename: R I
authors.initials: RI
authors.lastname: Harris
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000403:Airway Resistance; D000818:Animals; D002986:Clinical Trials as Topic; D003888:Desensitization, Immunologic / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006023:Glycoproteins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008925:Mites; D015337:Multicenter Studies as Topic; D009299:Nasal Provocation Tests; D012221:Rhinitis, Allergic, Perennial / Q000628:therapy*
chemical_list: D000276:Adjuvants, Immunologic; D006023:Glycoproteins; C038866:conjuvac