title: Use of ketoconazole in the treatment of canine nasal aspergillosis.
abstract: Fifteen dogs with nasal aspergillosis were treated with ketoconazole (5 mg/kg of body weight, q 12 h, PO) for 2 to 18 weeks. Four dogs whose conditions deteriorated during treatment received ketoconazole for less than the prescribed 6 weeks. Six months or more later, only 47% of the dogs were determined to be disease-free, on the basis of no fungal growth on culture. It was concluded that ketoconazole at this dosage is a useful treatment for canine nasal aspergillosis, but is no more effective than thiabendazole.
authors.affiliation: Veterinary Hospital, University of Liverpool, UK.
authors.forename: N J
authors.initials: NJ
authors.lastname: Sharp
authors.forename: M
authors.initials: M
authors.lastname: Sullivan
mesh_terms: D000818:Animals; D001228:Aspergillosis / Q000188:drug therapy / Q000662:veterinary*; D001232:Aspergillus fumigatus; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007654:Ketoconazole / Q000627:therapeutic use*; D009668:Nose Diseases / Q000188:drug therapy / Q000662:veterinary*; D013827:Thiabendazole / Q000627:therapeutic use
chemical_list: D013827:Thiabendazole; D007654:Ketoconazole