The in vitro effect of methylmercuric chloride on superoxide dismutase activity of pig platelets.
Incubation of the suspension of washed pig platelets with methylmercuric chloride (MeHg) caused decrease of superoxide dismutase (SOD) activity at the concentrations of MeHg 10(-5)-10(-4) mol/l. We also observed the increase of enzyme activity at low concentrations of MeHg (10(-7)-10(-6) mol/l). MeHg affects the SOD activity similarly to other mercurials which are known to react with sulfhydryl groups, and differentially influence enzymatic systems.
Kostka
B
B
Department of Biochemistry, Medical Academy, Lódź, Poland.
Krajewska
U
U
Lipecka
K
K
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D066298:In Vitro Techniques; D008767:Methylmercury Compounds / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood*; D013552:Swine
D008767:Methylmercury Compounds; D013482:Superoxide Dismutase; C004925:methylmercuric chloride