title: [Osteocalcin or bone GLA-protein].
abstract: Osteocalcin or GLA bone protein, the most abundant of non-collagen proteins in bone, is produced only by osteoblasts. Synthesis is enhanced by the active form of vitamin D. Most of the osteocalcin produced combines with hydroxyapatite crystals, but a small proportion is circulated in the bloodstream and eliminated by the kidneys. Because bone resorption and bone formation are closely linked, serum osteocalcin is a specific and reliable marker of bone tissue activity.
authors.forename: R
authors.initials: R
authors.lastname: Mariani
authors.forename: S
authors.initials: S
authors.lastname: Altarès
authors.forename: E
authors.initials: E
authors.lastname: Bérard
mesh_terms: D002135:Calcium-Binding Proteins / Q000096:biosynthesis / Q000097:blood / Q000502:physiology; D006801:Humans; D015675:Osteocalcin
chemical_list: D002135:Calcium-Binding Proteins; D015675:Osteocalcin
vernacular_title: L'ostéocalcine ou GLA-protéine osseuse.