Therapy of the acute porphyrias.
In the management of acute porphyria it is essential to be aware of the potential for many drugs to induce porphyrin synthesis and thus precipitate the acute porphyric crisis. In this review, lists of drugs unsafe and safe for use in the porphyrias are presented. In addition, therapeutic regimens are described which are appropriate to the porphyric subject. These include the use of high carbohydrate intake and the intravenous infusion of haem arginate.
Moore
M R
MR
University Department of Medicine, Western Infirmary, Glasgow, Scotland.
McColl
K E
KE
D004040:Dietary Carbohydrates / Q000627:therapeutic use; D064420:Drug-Related Side Effects and Adverse Reactions; D006418:Heme / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000150:complications; D009325:Nausea / Q000150:complications / Q000628:therapy; D010146:Pain / Q000150:complications; D059408:Pain Management; D011164:Porphyrias / Q000139:chemically induced* / Q000178:diet therapy / Q000188:drug therapy; D011166:Porphyrins / Q000096:biosynthesis; D012640:Seizures / Q000150:complications / Q000628:therapy; D013610:Tachycardia / Q000150:complications; D014839:Vomiting / Q000150:complications / Q000628:therapy
D004040:Dietary Carbohydrates; D011166:Porphyrins; D006418:Heme