title: Bovine serum conglutinin is a lectin which binds non-reducing terminal N-acetylglucosamine, mannose and fucose residues.
abstract: Carbohydrate recognition by bovine serum conglutinin has been investigated by inhibition and direct binding assays using glycoproteins and polysaccharides from Saccharomyces cerevisiae (baker's yeast), and neoglycolipids derived from N-acetylglucosamine oligomers, mannobiose and human milk oligosaccharides. The results clearly show that conglutinin is a lectin which binds terminal N-acetylglucosamine, mannose and fucose residues as found in chitobiose (GlcNAc beta 1-4GlcNAc), mannobiose (Man alpha 1-3Man) and lacto-N-fucopentaose II [Fuc alpha 1-4(Gal beta 1-3)GlcNAc beta 1-3Gal beta 1-4Glc] respectively.
authors.affiliation: Section of Glycoconjugate Research, Clinical Research Centre, Harrow, Middx., U.K.
authors.forename: R W
authors.initials: RW
authors.lastname: Loveless
authors.forename: T
authors.initials: T
authors.lastname: Feizi
authors.forename: R A
authors.initials: RA
authors.lastname: Childs
authors.forename: T
authors.initials: T
authors.lastname: Mizuochi
authors.forename: M S
authors.initials: MS
authors.lastname: Stoll
authors.forename: R G
authors.initials: RG
authors.lastname: Oldroyd
authors.forename: P J
authors.initials: PJ
authors.lastname: Lachmann
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D002417:Cattle; D037222:Collectins; D003168:Complement Fixation Tests; D004187:Disaccharides; D005643:Fucose / Q000378:metabolism*; D005936:Glucans / Q000378:metabolism; D005944:Glucosamine / Q000031:analogs & derivatives*; D037102:Lectins / Q000378:metabolism*; D008351:Mannans / Q000378:metabolism; D008358:Mannose / Q000378:metabolism*; D009844:Oligosaccharides / Q000378:metabolism; D012441:Saccharomyces cerevisiae; D012712:Serum Globulins / Q000378:metabolism*
chemical_list: D037222:Collectins; D004187:Disaccharides; D005936:Glucans; D037102:Lectins; D008351:Mannans; D009844:Oligosaccharides; D012712:Serum Globulins; C024014:conglutinin; C014647:mannobiose; C041762:lacto-N-fucopentaose II; D005643:Fucose; C032438:chitobiose; D005944:Glucosamine; D008358:Mannose; D000117:Acetylglucosamine