Influence of antimucin antibody in kidney transplantation.
A protein in saliva that is resistant to boiling and has a molecular weight greater than 400,000 daltons was found. Antibody against this antigen occurred naturally in about 20% of 92 normal and 334 dialysis patients. This antibody was associated with an early graft failure in studies of 201 first and 133 multiple graft patients. The effect was strong in male patients and absent in female patients. This antimucin antibody may explain some early graft failure in negative crossmatches.
Chia
D
D
UCLA Tissue Typing Laboratory, Department of Surgery 90024.
Terasaki
P I
PI
Casuga
E
E
Ozawa
M
M
D000906:Antibodies / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D009077:Mucins / Q000276:immunology*; D012463:Saliva / Q000276:immunology*
D000906:Antibodies; D009077:Mucins