title: Unilateral topical cortical application of penicillin: electrographic aspects. A new complement to an old model.
abstract: In 7 cats 800 IU of penicillin were applied diffusely over one hemisphere on the exposed neocortex. After 40 min all animals showed bilateral and synchronous burst discharges with a higher amplitude at the hemisphere where the penicillin had been applied. These data fill a gap in the literature concerning feline generalized penicillin epilepsy, in which penicillin is applied bilaterally on the exposed neocortex.
authors.affiliation: Laboratory of Functional Neurosurgery, University of São Paulo, School of Medicine, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Cukiert
authors.forename: S W
authors.initials: SW
authors.lastname: Baumel
authors.forename: M S
authors.initials: MS
authors.lastname: Andrioli
authors.forename: R
authors.initials: R
authors.lastname: Marino
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D004195:Disease Models, Animal; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D010406:Penicillins / Q000008:administration & dosage*
chemical_list: D010406:Penicillins