title: [Evaluation of severe dysplasia and carcinoma in situ detected by directed biopsy].
abstract: Eighty women with Papanicolaou smears groups IIIa and IIIb and an abnormal colposcopic picture, where colposcopic biopsy pathologic results showed severe dysplasia or carcinoma in situ, were analyzed. Severe dysplasia was found in 51 (63.7%) and carcinoma in situ in 29 (36.2%)cases. By using methods of a definitive diagnostic value, in cases of severe dysplasia, the early diagnosis was confirmed in 24 (47.1%) cases, in 14 (27.4%) cases carcinoma in situ was detected, in 3 (5.9%) moderate dysplasia, in 2 (3.9%) mild dysplasia, and in 8 (15.7%) cases benign histologic changes were found. Carcinoma in situ detected by colposcopy-directed biopsies was confirmed, after a definitive diagnostic procedure, in 24 (82.8%) cases, in 3 cases (10.3%) severe dysplasia was found and in 2 (6.9%) cases there were benign histologic changes. The results suggest that carcinoma in situ and severe dysplasia are vulnerable lesions which can be transformed into a lower grade or even completely disappear by directed biopsies. Such an evolution is significantly more to be expected within the population with an abnormal colposcopic picture if lesions cover not more than one fourth of the cervical circumference.
authors.forename: M
authors.initials: M
authors.lastname: Milojković
authors.forename: Z
authors.initials: Z
authors.lastname: Makarović
authors.forename: M
authors.initials: M
authors.lastname: Pajtler
mesh_terms: D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000473:pathology; D003127:Colposcopy; D003581:Cytodiagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology
vernacular_title: Procjena teske displazije i karcinoma in situ otkrivenih ciljanom biopsijom.