title: The effect of hydroxyethylrutoside and its combination with acetylsalicylic acid in patients with obliterative atherosclerosis.
abstract: The effect of 7-mono-hydroxyethylrutoside and its combination with acetylsalicylic acid was evaluated in a controlled clinical trial, performed in 105 patients with obliterative atherosclerosis of the lower limbs, and using non-invasive measurement of peripheral haemodynamic parameters--blood flow during reactive hyperaemia and ankle systolic blood pressure. Patients, randomized into three groups, received either placebo or 7-mono-hydroxyethylrutoside alone or in combination with acetylsalicylic acid for 12 months. The placebo group showed a decrease in maximum calf blood flow and a decrease in ankle systolic pressure. Administration of 7-mono-hydroxyethylrutoside did not lead to any significant changes in systolic pressure but there was a decrease in the maximum calf blood flow. There were no statistically significant changes in patients receiving the 7-mono-hydroxyethylrutoside and acetylsalicylic acid combination who, by contrast, showed a tendency to increased values of the parameters measured.
authors.affiliation: Institute of Clinical and Experimental Medicine, Cardiovascular Research Programme, Prague, Czechoslovakia.
authors.forename: K
authors.initials: K
authors.lastname: Roztocil
authors.forename: I
authors.initials: I
authors.lastname: Oliva
authors.forename: I
authors.initials: I
authors.lastname: Prerovský
authors.forename: J
authors.initials: J
authors.lastname: Linhart
mesh_terms: D000328:Adult; D000700:Analgesics / Q000008:administration & dosage*; D000925:Anticoagulants / Q000008:administration & dosage*; D001162:Arteriosclerosis Obliterans / Q000188:drug therapy*; D001241:Aspirin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006896:Hydroxyethylrutoside / Q000008:administration & dosage / Q000031:analogs & derivatives*; D007511:Ischemia / Q000188:drug therapy; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010991:Plethysmography; D012431:Rutin / Q000031:analogs & derivatives*
chemical_list: D000700:Analgesics; D000925:Anticoagulants; D006896:Hydroxyethylrutoside; D012431:Rutin; C010843:aloxiprin; C053279:troxevasin; D001241:Aspirin