Treatment of premenstrual depression with nortriptyline: a pilot study.
There are no reports on treatment of premenstrual syndrome with antidepressants, although depression is a common symptom of the syndrome. Eleven women who met DSM-III-R criteria for late luteal phase dysphoric disorder were treated with nortriptyline in an open pilot study after they failed to respond to placebo or another medication. Eight of 11 patients had a good therapeutic response. The efficacy of antidepressants in the treatment of premenstrual depression needs confirmation with double-blind studies.
Harrison
W M
WM
New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, NY 10032.
Endicott
J
J
Nee
J
J
D000328:Adult; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009661:Nortriptyline / Q000627:therapeutic use*; D010043:Outcome and Process Assessment, Health Care; D010865:Pilot Projects; D010919:Placebos; D011293:Premenstrual Syndrome / Q000188:drug therapy* / Q000523:psychology; D011569:Psychiatric Status Rating Scales
D010919:Placebos; D009661:Nortriptyline