title: Further observation of Japanese Creutzfeldt-Jacob disease with widespread amyloid plaques.
abstract: An autopsy case of Creutzfeld-Jacob disease with widespread amyloid plaques is reported. A 45-year-old Japanese man, whose father had died of a similar disease, had a 5-year illness characterized by progressive cerebellar signs. Mental changes and brain-stem signs developed in the late stage. Myoclonus frequently occurred. Akinetic mutism ensued. The autopsy revealed spongiform encephalopathy with widespread amyloid plaques and extensive degeneration of the white matter. This disease, Western Gerstmann-Sträussler-Scheinker disease and panencephalopathic type of Creutzfeld-Jacob disease are discussed.
authors.affiliation: Division of Pathology, Kanagawa Rehabilitation Centre, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yagishita
authors.forename: K
authors.initials: K
authors.lastname: Iwabuchi
authors.forename: N
authors.initials: N
authors.lastname: Amano
authors.forename: S
authors.initials: S
authors.lastname: Yokoi
mesh_terms: D000682:Amyloid / Q000032:analysis*; D016229:Amyloid beta-Peptides; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides