The effect of renal transplantation on a major endogenous ligand retained in uremic serum.
The effects of renal transplantation on serum concentrations of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) and indole-3-acetic acid (IAA), which are endogenous ligands retained in uremic serum, and on phenytoin binding to serum protein were investigated. IAA, a weakly bound ligand, was rapidly excreted by the transplanted kidney during the first one to three days after renal transplantation, but CMPF, a strongly bound ligand, was slowly excreted. The binding defect of phenytoin was partially corrected by transplantation during the period of study. The results suggested that the prolonged drug binding defect observed despite successful renal transplantation is caused by a slower decrease of strongly bound ligands such as CMPF retained in uremic serum; hypoalbuminemia, usually observed after transplantation, may also contribute to this phenomenon.
Mabuchi
H
H
Department of Internal Medicine and Nephrology, Nishijin Hospital, Kyoto, Japan.
Nakahashi
H
H
Hamajima
T
T
Aikawa
I
I
Oka
T
T
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005663:Furans / Q000097:blood* / Q000493:pharmacokinetics; D006801:Humans; D007210:Indoleacetic Acids / Q000097:blood*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000097:blood*; D011422:Propionates / Q000097:blood* / Q000493:pharmacokinetics; D011485:Protein Binding; D014462:Ultrafiltration; D014511:Uremia / Q000097:blood*
D005663:Furans; D007210:Indoleacetic Acids; D011422:Propionates; D010672:Phenytoin; C041693:3-carboxy-4-methyl-5-propyl-2-furanpropionic acid