title: [Creation and analysis of a bank of chromosomal genes of Streptococcus group A].
abstract: The representative genomic library of chromosomal genes has been constructed for streptococcus group A serotype M48 strain 1/64 on the vector lambda L 47.1. Screening of the obtained genomic library by hybridization and immunological techniques revealed about 50 clones producing the streptococcal antigens (extracellular nonidentified products and non-type specific structural streptococcal proteins). Among the recombinant clones three were found to harbour the genetic determinants for M-protein. One the clones contains a determinant coding for epitopes crossreacting with antisera to M-proteins of other serotypes and a protective epitope. The presence of the latter was tested in an indirect bactericidal test.
authors.forename: L B
authors.initials: LB
authors.lastname: Nesterchuk
authors.forename: T V
authors.initials: TV
authors.lastname: Gupalova
authors.forename: T G
authors.initials: TG
authors.lastname: Kolesnichenko
authors.forename: A N
authors.initials: AN
authors.lastname: Suvorov
authors.forename: V I
authors.initials: VI
authors.lastname: Golubkov
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000235:genetics; D002352:Carrier Proteins; D005798:Genes, Bacterial; D007256:Information Systems; D009895:Opsonin Proteins / Q000235:genetics; D011817:Rabbits; D013297:Streptococcus pyogenes / Q000235:genetics*
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D009895:Opsonin Proteins; C014689:streptococcal M protein
vernacular_title: Sozdanie i analiz banka khromosomnykh genov Streptokokka gruppy A.