title: Human megakaryocytopoiesis.
abstract: The study of human megakaryocytopoiesis has grown tremendously in the past decade. Numerous advances and improvements in methodologies have contributed to a much enhanced understanding of the developmental biology of this platelet-producing cell. This chapter reviews these methodologies, discusses current concepts regarding the regulation of human megakaryocyte development, and alludes to the clinical significance of these advances in the field.
authors.affiliation: Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.
authors.forename: R B
authors.initials: RB
authors.lastname: Sims
authors.forename: A M
authors.initials: AM
authors.lastname: Gewirtz
mesh_terms: D001791:Blood Platelet Disorders / Q000503:physiopathology*; D001792:Blood Platelets / Q000502:physiology; D002478:Cells, Cultured; D003001:Cloning, Molecular; D006801:Humans; D008533:Megakaryocytes / Q000502:physiology*; D009190:Myelodysplastic Syndromes / Q000503:physiopathology