title: [The use of human insulin in 3 patients with diabetes mellitus and insulin resistance].
abstract: Human insulin was applied to three insulin resistant diabetic patients with moderate insulin needs of 1.9 U/kg body mass/24 hours. The mean level of the insulin antibodies was 61%. In all three patients biostator control was carried out before beginning the treatment with human insulin. After an 8 month treatment a satisfactory compensation of diabetes was achieved with an average insulin dose of 1.02 U/kg body mass, a considerable lowering of the mean blood sugar level and a reduction of the glycosilated hemoglobin examined in two of the patients. At the end of the 8 month period the level of the insulin antibodies was considerably lowered in all three patients. The advantage of human insulin as an alternative for the treatment of immunologic insulin resistance is pointed out.
authors.forename: V
authors.initials: V
authors.lastname: Khristov
authors.forename: A
authors.initials: A
authors.lastname: Manov
mesh_terms: D000368:Aged; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000276:immunology; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D007330:Insulin Antibodies / Q000032:analysis; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
chemical_list: D007328:Insulin; D007330:Insulin Antibodies
vernacular_title: Prilozhenie na choveshki insulin pri trima bolni sŭs zakharen diabet i insulinova rezistentnost.