Recessive mutations and chromosome deletions leading to cancer.
This review examines the effect that a small chromosome deletion affecting a specific DNA sequence may have in producing a state of 'hemizygosity' for a gene or genes, and so triggering malignancy of the cells concerned. The association between such deletions and a variety of cancers will be considered and the implications for clinical practice will be outlined.
Berne
J
J
Department of Surgery, United Medical School, Guy's Hospital, London, UK.
McColl
I
I
Adinolfi
M
M
D002869:Chromosome Aberrations / Q000235:genetics*; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D004273:DNA, Neoplasm / Q000235:genetics; D005808:Genes, Recessive; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes
D004273:DNA, Neoplasm