title: Pharmacokinetic data of propranolol enantiomers in a comparative human study with (S)- and (R,S)-propranolol.
abstract: The pharmacokinetics of (S)-propranolol were compared after the oral administration of a 40 mg dose of the pure enantiomer and an 80 mg dose of a racemic mixture of (R,S)-propranolol. The results of this study indicate that the bioavailability of (S)-propranolol, as expressed by the mean area under the concentration-time curve (AUC) and maximum serum concentration, is lower after 40 mg of the optically pure drug than after the racemic drug.
authors.affiliation: Institute of Pharmaceutical Chemistry, Karl-Franzens-University of Graz, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Lindner
authors.forename: M
authors.initials: M
authors.lastname: Rath
authors.forename: K
authors.initials: K
authors.lastname: Stoschitzky
authors.forename: H J
authors.initials: HJ
authors.lastname: Semmelrock
mesh_terms: D000328:Adult; D001682:Biological Availability; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D011433:Propranolol / Q000493:pharmacokinetics*; D013237:Stereoisomerism
chemical_list: D011433:Propranolol