Gastrointestinal scintigraphy with 99mTc-DTPA labeled tablets in fed and fasting subjects.
The in vitro and in vivo dissolution of a sustained release theophylline formulation labeled with 99mTc-diethyltriaminepentaacetic acid (DTPA) has been monitored in six subjects with a scintillation camera. The study was performed in fasting conditions and was repeated after ingestion of a standardized meal. Results showed that the presence of food in the stomach dramatically increased the oesoduodenal transit time of the tablet (74 +/- 27 min vs 352 +/- 77 min, P less than 0.001) but did not modify the biodisponibility of theophylline. This study is another example when scintigraphy can be of definite value in pharmacokinetics.
Maublant
J C
JC
Division of Nuclear Medicine, Centre Jean Perrin, Clermont-Ferrand, France.
Sournac
M
M
Aiache
J M
JM
Veyre
A
A
D000328:Adult; D003692:Delayed-Action Preparations; D004435:Eating; D005215:Fasting; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid; D013607:Tablets; D013667:Technetium; D016284:Technetium Tc 99m Pentetate
D003692:Delayed-Action Preparations; D009942:Organometallic Compounds; D013607:Tablets; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate