title: Immunohistologic findings and results of treatment with cyclosporine in ligneous conjunctivitis.
abstract: Using immunohistochemical techniques, we studied ligneous conjunctival lesions from two patients. A significant immune reaction was detected that was characterized by activated T lymphocytes and focal accumulation of plasma cells and B lymphocytes. Immunofluorescent studies demonstrated that IgG was a prominent component of the amorphous hyaline material seen in these lesions. After previous treatment methods had failed, both patients were treated with excisional biopsy and topical cyclosporine. Patient 1 had a dramatic response, with complete resolution of the lesions. Patient 2 had a significant improvement resulting in small, slow-growing recurrences instead of the rapid and extensive recurrences that occurred before treatment with cyclosporine.
authors.affiliation: Department of Ophthalmology, University of Minnesota, Minneapolis 55455.
authors.forename: E J
authors.initials: EJ
authors.lastname: Holland
authors.forename: C C
authors.initials: CC
authors.lastname: Chan
authors.forename: T
authors.initials: T
authors.lastname: Kuwabara
authors.forename: A G
authors.initials: AG
authors.lastname: Palestine
authors.forename: J J
authors.initials: JJ
authors.lastname: Rowsey
authors.forename: R B
authors.initials: RB
authors.lastname: Nussenblatt
mesh_terms: D000328:Adult; D002675:Child, Preschool; D003228:Conjunctiva / Q000473:pathology; D003231:Conjunctivitis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008214:Lymphocytes / Q000145:classification / Q000473:pathology
chemical_list: D003524:Cyclosporins