[Comparison of the cytotoxic activity of doxorubicin and epirubicin by an in vitro test].
In a group of 34 tumours representing 9 various human neoplasms the cytotoxic activity was compared of doxorubicin (Adriamycin) and epirubicin (Farmorubicin) in vitro. The method was based on measurements of the degree of inhibition of 3H-uridine incorporation in a suspension of cells of the tumour incubated with the cytostatic agent as compared to the activity in the control group. In 7 cases (21%) the tumours were sensitive to both agents, 26 tumours (76%) failed to respond to either drug. In one case the tumour responded only to epirubicin (3%) which suggests a probable incomplete cross-resistance between both cytostatics. A positive correlation between increased concentration of the drugs used in this experiment and the increase of the cytostatic effect in the group of tumours sensitive in vitro suggests the necessity of raising the dosage of less toxic epirubicin in clinical trials.
Czownicki
Z
Z
Rosińska
U
U
Kilka
C
C
D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003470:Culture Media; D004317:Doxorubicin / Q000494:pharmacology / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D015251:Epirubicin / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D003470:Culture Media; D015251:Epirubicin; D004317:Doxorubicin
Porównanie aktywności cytotoksycznej doksorubicyny i epirubicyny testem in vitro.