1H NMR of plasma for detecting cancer. The effect of trauma on linewidths.
The specificity of detecting cancer using the methyl and methylene linewidths in the 1H NMR spectrum of plasma has been examined for patients with brain tumors. Apparently healthy controls are distinguished from patients with metastatic brain tumors or malignant primary intracranial neoplasms, although the amount of overlap with the latter group precludes the use of the method as a diagnostic tool. Furthermore, patients with benign primary intracranial neoplasms are not distinguished from those with malignant primary brain tumors, and non-tumor neurological patients with traumatic head injury are not distinguished from cancer patients. Surgical treatment of neurological patients results in a significant narrowing of the 1H NMR bands of interest, particularly for patients initially exhibiting broad lines. The narrowing persists for at least 3 weeks. This effect of surgical or other trauma on the 1H NMR linewidths indicates that the method is unsuitable for assessing the efficacy of surgical treatment of cancer.
Sutherland
G
G
Department of Radiology, University of Manitoba, Winnipeg, Canada.
Peeling
J
J
D001774:Blood Chemical Analysis; D001930:Brain Injuries / Q000097:blood / Q000175:diagnosis*; D001932:Brain Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D009682:Magnetic Resonance Spectroscopy
D008074:Lipoproteins