title: Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen.
abstract: Macrophage inflammatory protein-1 (MIP-1) produced a monophasic fever of rapid onset whose magnitude was equal to or greater than that of fevers produced with either recombinant human cachectin (or tumor necrosis factor) or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 was not inhibited by the cyclooxygenase inhibitor ibuprofen. Thus, MIP-1 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase inhibitors.
authors.affiliation: Laboratory of Medical Biochemistry, Rockefeller University, New York, NY 10021.
authors.forename: G
authors.initials: G
authors.lastname: Davatelis
authors.forename: S D
authors.initials: SD
authors.lastname: Wolpe
authors.forename: B
authors.initials: B
authors.lastname: Sherry
authors.forename: J M
authors.initials: JM
authors.lastname: Dayer
authors.forename: R
authors.initials: R
authors.lastname: Chicheportiche
authors.forename: A
authors.initials: A
authors.lastname: Cerami
mesh_terms: D000818:Animals; D002630:Chemotactic Factors / Q000302:isolation & purification / Q000502:physiology*; D015232:Dinoprostone / Q000502:physiology; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006493:Heparin / Q000378:metabolism; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology; D007375:Interleukin-1 / Q000502:physiology; D016209:Interleukin-8; D009504:Neutrophils / Q000502:physiology; D011817:Rabbits; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D002630:Chemotactic Factors; D007375:Interleukin-1; D016209:Interleukin-8; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D006493:Heparin; D015232:Dinoprostone; D007052:Ibuprofen