title: Nobel lecture in physiology or medicine--1988. Selective inhibitors of dihydrofolate reductase.
authors.affiliation: Burroughs Wellcome Fund, Research Triangle Park, North Carolina 27709.
authors.forename: G H
authors.initials: GH
authors.lastname: Hitchings
mesh_terms: D000818:Animals; D001419:Bacteria / Q000201:enzymology; D005492:Folic Acid / Q000031:analogs & derivatives / Q000378:metabolism*; D005493:Folic Acid Antagonists; D049673:History, 20th Century; D006801:Humans; D008727:Methotrexate / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D009613:Nobel Prize; D011487:Protein Conformation; D013762:Tetrahydrofolate Dehydrogenase / Q000266:history / Q000378:metabolism; D013763:Tetrahydrofolates / Q000378:metabolism; D014295:Trimethoprim / Q000494:pharmacology
chemical_list: D005493:Folic Acid Antagonists; D013763:Tetrahydrofolates; C010920:dihydrofolate; D005492:Folic Acid; D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate