title: Stimulation of insulin secretion by transforming growth factor-beta.
abstract: Effects of transforming growth factor-beta (TGF-beta) on insulin secretion were studied in rat pancreatic islets. When islets were incubated in a batch incubation system with various concentrations of TGF-beta in the presence of 2.8 mM glucose, TGF- beta increased insulin release in a concentration-dependent manner. Both TGF- beta 1 and TGF- beta 2 were equally effective. The stimulatory action of TGF- beta was greater in the presence of stimulatory concentration of glucose. In perifusion system, TGF- beta induced an immediate monotonic increase in insulin secretion. These results indicate that TGF- beta is a stimulator of insulin secretion.
authors.affiliation: Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Totsuka
authors.forename: M
authors.initials: M
authors.lastname: Tabuchi
authors.forename: I
authors.initials: I
authors.lastname: Kojima
authors.forename: Y
authors.initials: Y
authors.lastname: Eto
authors.forename: H
authors.initials: H
authors.lastname: Shibai
authors.forename: E
authors.initials: E
authors.lastname: Ogata
mesh_terms: D000818:Animals; D005947:Glucose / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D015291:Transforming Growth Factors / Q000494:pharmacology*
chemical_list: D007328:Insulin; D015291:Transforming Growth Factors; D005947:Glucose