Gastric effects of PAF.
PAF is one of the most potent ulcerogens yet known and it has been proposed that it is involved in the pathogenesis of different diseases affecting the gastric mucosa. The present paper reviews the gastric actions of PAF and special emphasis is made in analyzing the mechanisms responsible for such actions. A role for PAF in gastric damage during septic shock seems well established, and the clinical use of selective PAF antagonists in such situations seems appropriate. The involvement of PAF in other types of gastric mucosal damage is less clear and needs further investigation.
Esplugues
J V
JV
Departamento de Farmacología y Farmacotecnia, Universidad de Valencia, Spain.
Whittle
B J
BJ
D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects*; D010437:Peptic Ulcer / Q000139:chemically induced / Q000503:physiopathology; D010972:Platelet Activating Factor / Q000494:pharmacology*
D010972:Platelet Activating Factor