A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells.
Facultative intracellular pathogens pose an important health problem because they circumvent a primary defense mechanism of the host: killing and degradation by professional phagocytic cells. A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intracellular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte. This gene may prove to be a regulatory element in the expression of virulence functions.
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Department of Molecular Biology, Scripps Clinic and Research Foundation, La Jolla, CA 92037.
Groisman
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Heffron
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D000818:Animals; D001798:Blood Proteins / Q000502:physiology*; D003594:Cytoplasmic Granules / Q000032:analysis; D004269:DNA, Bacterial / Q000235:genetics; D023082:Defensins; D005798:Genes, Bacterial; D006801:Humans; D008264:Macrophages / Q000032:analysis / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D009504:Neutrophils / Q000032:analysis; D009693:Nucleic Acid Hybridization; D010586:Phagocytes / Q000502:physiology*; D010957:Plasmids; D011817:Rabbits; D012486:Salmonella typhimurium / Q000235:genetics* / Q000472:pathogenicity
D001798:Blood Proteins; D004269:DNA, Bacterial; D023082:Defensins