title: Androgens, progestagens and agonistic behaviour: a review.
abstract: The relationship between androgens, progestagens and agonistic behaviour is reviewed. Most literature concerned the effects of hormones on aggression; little information was available on hormonal influences on fear. Difference in aggression levels between males and females may be explained by assuming the existence of a gender difference in motivation, which, among other factors, is controlled by androgen and progestagen levels in peripheral blood. Androgens and progestagens are metabolised mainly by 5 alpha-reductase in the target organs. In the brain, aromatisation of testosterone also plays a role. The metabolites of testosterone may exert the same organising and activating influence as testosterone on juvenile and adult brain tissue, respectively. In some animal species testosterone secretion appears to be influenced by social and environmental variables. Conversely, alterations in plasma androgen levels have been found to affect behaviour. Dominant and/or aggressive individuals tend to show higher plasma testosterone levels than submissive and/or less aggressive animals. Among other mechanisms, competitive inhibition of androgen action at a central level, by progestagens acting as antagonists of androgens, may be important.
authors.affiliation: Small Animal Clinic, University of Utrecht, The Netherlands.
authors.forename: B W
authors.initials: BW
authors.lastname: Knol
authors.forename: S T
authors.initials: ST
authors.lastname: Egberink-Alink
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000378:Agonistic Behavior / Q000187:drug effects* / Q000502:physiology; D000728:Androgens / Q000494:pharmacology* / Q000502:physiology; D000818:Animals; D005260:Female; D008297:Male; D011372:Progestins / Q000494:pharmacology* / Q000502:physiology
chemical_list: D000728:Androgens; D011372:Progestins