title: Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production.
abstract: Toxic shock syndrome-associated staphylococcal and streptococcal exotoxins were tested for an ability to induce the production of tumor necrosis factor (TNF). Staphylococcal enterotoxins B and C1, along with streptococcal pyrogenic exotoxin A, all induced TNF production in a dose-dependent manner, with production peaking on the average at 3 days but continuing over the 6 days tested. This time course of exotoxin-induced TNF production contrasts with the 1-day peak-2-day duration observed with endotoxin as the stimulus and may be significant to development of toxic shock syndrome.
authors.affiliation: Department of Microbiology, University of Minnesota, Minneapolis 55455.
authors.forename: D J
authors.initials: DJ
authors.lastname: Fast
authors.forename: P M
authors.initials: PM
authors.lastname: Schlievert
authors.forename: R D
authors.initials: RD
authors.lastname: Nelson
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D002460:Cell Line; D005098:Exotoxins / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D011749:Pyrogens; D012772:Shock, Septic / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000502:physiology*; D013297:Streptococcus pyogenes / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D011749:Pyrogens; D014409:Tumor Necrosis Factor-alpha