Heparin-induced thrombocytopenia.
Heparin-induced thrombocytopenia is the most important idiosyncratic drug-induced thrombocytopenia because of its high frequency and association with arterial thrombosis. Recent evidence implicates heparin-IgG immune complexes in the pathogenesis of this disorder. New developments such as a diagnostic test for heparin-induced thrombocytopenia and current treatment recommendations are reviewed.
Warkentin
T E
TE
Department of Medicine, McMaster University Medical Centre, Ontario, Canada.
Kelton
J G
JG
D001158:Arteries / Q000503:physiopathology; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D013927:Thrombosis / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy
D006493:Heparin