Immunoprint pattern in patients with allergic bronchopulmonary aspergillosis in different stages.
Individual immunoprint patterns of sodium dodecylsulfate-polyacrylamide gel electrophoresis-separated Aspergillus fumigatus (Af) allergens/antigens were evaluated in 28 patients with allergic bronchopulmonary aspergillosis in stages II to V. It could be demonstrated that active disease (stage III) is characterized by a very strong IgE response against a variety of Af components, whereas the IgE antibody pattern in corticosteroid-treated patients who have demonstrated improvement is much weaker. In patients in remission (stage II), it is minimal. In contrast, many patients in stage V without corticosteroid treatment demonstrated a strong reactivity of IgE antibodies, indicating persisting active disease. The pattern of IgG antibodies with individual Af components resembles, in general, that of IgE antibodies; however, discrimination between different stages and between treated patients is much weaker. Our results indicate that a certain relationship between the different stages of allergic bronchopulmonary aspergillosis and Af immunoprint patterns exists.
Baur
X
X
Pneumologische Abteilung, Medizinische Klinik I, Universität, München, West Germany.
Weiss
W
W
Jarosch
B
B
Menz
G
G
Schoch
C
C
Schmitz-Schumann
M
M
Virchow
C
C
D000485:Allergens / Q000302:isolation & purification*; D000908:Antibodies, Fungal / Q000302:isolation & purification*; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000276:immunology*; D001232:Aspergillus fumigatus / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D015151:Immunoblotting; D007073:Immunoglobulin E / Q000032:analysis; D011852:Radioallergosorbent Test
D000485:Allergens; D000908:Antibodies, Fungal; D007073:Immunoglobulin E