Dyes, antipsychotic drugs, and antimicrobial activity. Fragments of a development, with special reference to the influence of Paul Ehrlich.
The history of phenothiazines, from methylene blue via chlorpromazine to recently synthesized isomeric derivatives of various neuroleptics, is reviewed in the light of their antimicrobial activity and Paul Ehrlich's receptor concept. The latter is clearly in line with most modern theories concerning drug action of stereo-isomeric compounds.
Kristiansen
J E
JE
Dept of Clinical Pharmacology, Rigshospitalet Copenhagen, Denmark.
D000890:Anti-Infective Agents / Q000266:history* / Q000627:therapeutic use; D004396:Coloring Agents / Q000266:history* / Q000627:therapeutic use; D005858:Germany; D049672:History, 19th Century; D049673:History, 20th Century; D010640:Phenothiazines / Q000266:history* / Q000627:therapeutic use
D000890:Anti-Infective Agents; D004396:Coloring Agents; D010640:Phenothiazines