Dexamethasone in the treatment of bronchopulmonary dysplasia.
Sixteen chronically ventilator-dependent newborns with BPD were treated with one or more cycles of dexamethasone (0.5 mg/kg/day). In 11 cases extubation was possible during the therapy period. Ventilatory parameters were lowered in 3 other newborns. FIO2, respiratory rate, PIP, and PEEP, assessed before and after dexamethasone administration, decreased in a statistically significant way. Our data confirm the utility of dexamethasone in the extubation in chronically ventilated infants with BPD.
Benini
F
F
Department of Paediatrics, University of Padova, Italy.
Rubaltelli
F F
FF
Griffith
P
P
Sala
M
M
Zorzi
C
C
D001997:Bronchopulmonary Dysplasia / Q000188:drug therapy* / Q000503:physiopathology / Q000628:therapy; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007902:Length of Stay; D010102:Oxygen Inhalation Therapy; D012121:Respiration, Artificial; D012129:Respiratory Function Tests
D003907:Dexamethasone