An alternative view of heparin anticoagulation in acute focal brain ischemia.
Despite the lack of evidence of its efficacy, heparin therapy has been recommended for selected patients with ischemic stroke syndromes. However, heparin has procoagulant effects on platelet function and a propensity to produce serious side effects. When these factors are considered, heparin loses its appeal as a therapeutic agent for patients with acute focal cerebral ischemia.
Phillips
S J
SJ
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
D000208:Acute Disease; D000925:Anticoagulants / Q000627:therapeutic use; D001696:Biomechanical Phenomena; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy*; D002561:Cerebrovascular Disorders / Q000517:prevention & control; D006470:Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000517:prevention & control
D000925:Anticoagulants; D006493:Heparin