Preliminary study of the vascular dynamics of port-wine hemangioma with therapeutic implications for argon laser treatment.
The vascular dynamics of port-wine hemangioma have been studied in several ways in order to better understand blood flow factors. Utilizing a laser Doppler velocimeter, differential perfusion/blood flow was studied and contrasted to normal skin, compared to heat and cold challenges, and finally measured in relationship to argon laser treatment. Results indicate that port-wine hemangiomas do not necessarily have different perfusion than normal skin but respond less vigorously to heat challenges. Cooling showed no uniform response by port-wine hemangioma vessels, while injection with Xylocaine plus epinephrine resulted in a markedly decreased perfusion and vasoconstriction contrary to previously held theories. Argon laser treatment did not uniformly alter laser Doppler perfusion to a predictable degree. Laser Doppler velocimeter flow studies were not able to predict future good versus bad results of laser treatment.
Apfelberg
D B
DB
Department of Plastic and Reconstructive Surgery, Palo Alto Medical Foundation, Calif.
Smith
T
T
White
J
J
D000293:Adolescent; D000328:Adult; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006391:Hemangioma / Q000098:blood supply* / Q000601:surgery*; D006801:Humans; D006979:Hyperthermia, Induced; D007036:Hypothermia, Induced; D053685:Laser Therapy; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects; D012878:Skin Neoplasms / Q000098:blood supply* / Q000601:surgery*; D014463:Ultrasonography
D008012:Lidocaine; D004837:Epinephrine