title: Pigment cells and pigment cell tumors in fish.
abstract: The three basic pigment cell types found in poikilothermic vertebrates, melanocytes (melanin-producing cells), erythrophores (red or yellow pigment cells), and iridophores (iridescence-producing cells), are derived from neural crest. Neoplasms of pigment cells in fish are also of three phenotypes, melanomas (melanophoromas), erythrophoromas, and iridophoromas, showing the phenotypes of their corresponding normal pigment cells. These pigment cell tumors are among the most common types in bony fish and seem to be more common in fish than in mammals, including humans. Moreover, there are no mammalian neoplasms corresponding to erythrophoromas and iridophoromas in fish. The complexities in the nature and classification of pigment cell tumors in fish will be discussed on the basis of a survey of our collection of these tumors at the Cancer Institute. The etiology of pigment cell tumors in fish is obscure. In order to know whether activated oncogene is involved in the genesis of erythrophoromas in goldfish, the ras genes from normal and erythrophoroma cells were cloned and their nucleotide sequences were compared. The goldfish ras gene and human ras genes showed striking homology. However, no point mutation at the 12th codon was observed in ras genes isolated from erythrophoromas. Besides pigment cell tumors in fish, abnormal pigmentation or depigmentation in flounders associated with diseased conditions is also described.
authors.affiliation: Department of Experimental Pathology, Cancer Institute, Tokyo, Japan.
authors.forename: P
authors.initials: P
authors.lastname: Masahito
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: H
authors.initials: H
authors.lastname: Sugano
mesh_terms: D000818:Animals; D002856:Chromatophores / Q000473:pathology* / Q000648:ultrastructure; D005399:Fishes / Q000502:physiology*; D008545:Melanoma / Q000209:etiology / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology* / Q000648:ultrastructure