Reversibility of clearance impairment after subchronic test toner inhalation.
In a chronic study of a test toner in F-344 rats an impairment of alveolar clearance and increased toner retention were observed at the high and, to a lesser degree, at the middle exposure level throughout the study. The objectives of the present study were: 1. To investigate the nature and the time course of test toner and surrogate tracer alveolar clearance and toner retention behaviour following a subchronic exposure interval. 2. To investigate the dependence of the response upon the pulmonary burden of the test toner.
Bellmann
B
B
Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, FRG.
Muhle
H
H
Creutzenberg
O
O
Kilpper
R
R
Morrow
P
P
Mermelstein
R
R
D000280:Administration, Inhalation; D000818:Animals; D005260:Female; D008168:Lung / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D008657:Metabolic Clearance Rate; D008689:Methacrylates / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D051381:Rats; D011916:Rats, Inbred F344
D008689:Methacrylates