title: A retrospective study of 40 victims of crotalus snake bites. Analysis of the hepatic necrosis observed in one patient.
abstract: Forty patients with a diagnosis of snake bite were studied at the Infectious and Parasitic Disease Service of the Faculty of Medicine of Botucatu. Thirty were males and 10 females, ranging in age from 16 to 70 years. All were farm laborers and 35 of them were bitten in the lower limbs. Two of the 9 patients seen more than 6 hours after the bite died. The low mortality rate (5%) observed could be explained by the early care provided, by the use of appropriate doses of anti-crotalus serum, parenteral hydration, urine alkalinization with sodium bicarbonate and induction of osmotic diuresis with a mannitol solution. Anatomopathological examination of one of the patients who died revealed extensive hepatic necrosis. The authors discuss the possibility of the effect of a factor of snake venom in the genesis of hepatic necrosis and in the increased transaminase levels.
authors.forename: B
authors.initials: B
authors.lastname: Barraviera
authors.forename: J C
authors.initials: JC
authors.lastname: Bonjorno Júnior
authors.forename: D
authors.initials: D
authors.lastname: Arkaki
authors.forename: M A
authors.initials: MA
authors.lastname: Domingues
authors.forename: P C
authors.initials: PC
authors.lastname: Pereira
authors.forename: R P
authors.initials: RP
authors.lastname: Mendes
authors.forename: J M
authors.initials: JM
authors.lastname: Machado
authors.forename: D A
authors.initials: DA
authors.lastname: Meira
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000382:Agricultural Workers' Diseases / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012189:Retrospective Studies; D012423:Rural Health; D012909:Snake Bites / Q000150:complications*