Hypodontia in the beagle after perinatal whole-body 60Co gamma irradiation.
As part of a long-term study to evaluate health effects of pre- and postnatal irradiation, dental development was examined. Beagles were irradiated in utero at 8, 28, or 55 days postcoitus or postnatally at 2, 70, or 365 days postpartum. Whole-body 60Co gamma radiation doses ranged from 0 to 3.8 Gy. There was an age-dependent dose-related increase in premolar hypodontia for animals irradiated at 55 days postcoitus or 2 days postpartum with doses of 0.83 Gy or higher and for those irradiated at 28 days postcoitus with 1.2 Gy or higher.
Lee
A C
AC
Department of Radiology, College of Veterinary Medicine, Colorado State University, Fort Collins 80523.
Angleton
G M
GM
Benjamin
S A
SA
D000818:Animals; D000848:Anodontia / Q000209:etiology*; D003037:Cobalt Radioisotopes; D004285:Dogs; D005260:Female; D005720:Gamma Rays; D008297:Male; D009805:Odontogenesis / Q000528:radiation effects*; D011247:Pregnancy; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes