title: Local increase in interleukin-1-like activity following UVB irradiation of human skin in vivo.
abstract: Using an in vivo skin chamber method, we demonstrated increased release of interleukin-1 (IL-1)-like activity at the site of irradiation with 3 times the minimal erythema dose of ultraviolet B (UVB). IL-1-like activity was estimated using the mouse thymocyte amplification assay. UVB-augmented release of IL-1-like activity peaked 1 h after irradiation and levels returned to baseline by 2 h. Release of IL-1-like activity from human skin after exposure to UV radiation may account for some of the local and systemic features of the sunburn response.
authors.affiliation: Institute of Dermatology, St Thomas' Hospital, London, United Kingdom.
authors.forename: G M
authors.initials: GM
authors.lastname: Murphy
authors.forename: P M
authors.initials: PM
authors.lastname: Dowd
authors.forename: B N
authors.initials: BN
authors.lastname: Hudspith
authors.forename: J
authors.initials: J
authors.lastname: Brostoff
authors.forename: M W
authors.initials: MW
authors.lastname: Greaves
mesh_terms: D000328:Adult; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D012867:Skin / Q000528:radiation effects*; D013471:Sunburn / Q000209:etiology*; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D007375:Interleukin-1