[The effect of factors stimulating proliferation of hepatocytes on cholesterol esterification in the serum during liver regeneration].
Two-step regeneration of rat liver tissue was observed after partial hepatectomy. The first step involved mitosis of hepatocytes and the second step--division of the cells containing two nuclei and hypertrophy of hepatocytes. Both these steps of liver tissue regeneration were accompanied by hypercholesterolemia and a decrease in the cholesterol esterification activity in blood serum. The factors, stimulating hepatocyte proliferation, accelerated the reparative liver tissue regeneration due to activation of mitosis and the early division of the cells containing two nuclei. At the same time, the highest regeneration of the cholesterol esterification system was detected in circulation.
Konevalova
N Iu
NIu
Chirkina
I A
IA
Chirkin
A A
AA
D000818:Animals; D002455:Cell Division; D002788:Cholesterol Esters / Q000097:blood*; D006498:Hepatectomy; D015850:Interleukin-6; D008099:Liver / Q000166:cytology*; D008115:Liver Regeneration; D011506:Proteins / Q000302:isolation & purification / Q000502:physiology*; D051381:Rats
D002788:Cholesterol Esters; D015850:Interleukin-6; D011506:Proteins
Deĭstvie faktorov, stimuliruiushchikh proliferatsiiu gepatotsitov, na protsess ésterifikatsii kholesterina v syvorotke krovi pri regeneratsii pecheni.