Synthesis and alpha-glucosidase-inhibiting activity of a new alpha-glucosidase inhibitor, 4-O-alpha-D-glucopyranosylmoranoline and its N-substituted derivatives.
Various N-substituted derivatives of 4-O-alpha-D-glucopyranosylmoranoline have been synthesized, and their inhibitory activities against rabbit sucrase and maltase have been measured, as well as their effects on postprandial hyperglycemia in the sucrose-loaded rat, 4-O-alpha-D-Glucopyranosylmoranoline was also shown to have potent hypoglycemic activity in starch-loaded dogs.
Yoshikuni
Y
Y
Ezure
Y
Y
Seto
T
T
Mori
K
K
Watanabe
M
M
Enomoto
H
H
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D004187:Disaccharides / Q000138:chemical synthesis* / Q000494:pharmacology; D004285:Dogs; D065089:Glycoside Hydrolase Inhibitors; D008297:Male; D011817:Rabbits; D051381:Rats
D001786:Blood Glucose; D004187:Disaccharides; D065089:Glycoside Hydrolase Inhibitors; D017485:1-Deoxynojirimycin; C059893:4-O-glucopyranosylmoranoline