Effect of indomethacin administration on glucose homeostasis and pancreatic hormones in lactating goats.
To determine glucogenic and hormonal responses in ruminants to indomethacin, a prostaglandin synthetase inhibitor, four lactating Toggenburg goats were used in a crossover design. Fifteen milligrams of indomethacin or 3 ml of saline were injected subcutaneously twice daily with propionate infused intrajugularly at a rate of 2 mM/min for 75 min as a challenge. Plasma glucose concentrations were increased by indomethacin injections. Plasma concentrations of insulin, glucagon, and 6-keto-prostaglandin F1 alpha were not affected by indomethacin injections. Propionate infusion elevated plasma glucose, insulin, and glucagon concentrations. A decreased insulin release in response to propionate challenge was observed with indomethacin injections.
Jacquemet
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Division of Animal and Veterinary Sciences, West Virginia University, Morgantown 26506-6108.
Prigge
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EC
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D005934:Glucagon / Q000097:blood; D005943:Gluconeogenesis; D006041:Goats / Q000097:blood*; D006706:Homeostasis / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D007774:Lactation; D010187:Pancreatic Hormones / Q000097:blood*; D011247:Pregnancy; D011422:Propionates / Q000494:pharmacology; D012965:Sodium Chloride
D001786:Blood Glucose; D007328:Insulin; D010187:Pancreatic Hormones; D011422:Propionates; D012965:Sodium Chloride; D015121:6-Ketoprostaglandin F1 alpha; D005934:Glucagon; C029658:propionic acid; D007213:Indomethacin