Circulating immune complexes in sickle cell-beta zero thalassemia.
A serum fraction from patients with sickle cell-beta zero thalassemia prepared by treatment with polyethyleneglycol showed increased amounts of C1q-precipitable immune complexes, i.e., 216 micrograms/dl (range, 141-266 micrograms/dl) vs 181 micrograms/dl (range, 152-228 micrograms/dl) for controls (P less than 0.05), as well as increased amounts of protein. Levels of IgG, IgA, IgM, C3, C4 and factor B in the same fraction were within the normal range.
Donadi
E A
EA
Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
Carvalho
I F
IF
Falcão
R P
RP
D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood*; D002648:Child; D015922:Complement C1q / Q000032:analysis*; D005260:Female; D006451:Hemoglobin, Sickle / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013789:Thalassemia / Q000097:blood / Q000276:immunology*
D000936:Antigen-Antibody Complex; D006451:Hemoglobin, Sickle; D015922:Complement C1q