[Methotrexate in dermatology: current aspects].
The prescription of methotrexate (MTX) in dermatology is nowadays restricted for two main reasons: the toxicity of the drug and the availability of less toxic treatments (phototherapy and etretinate) in its main indication: psoriasis. However, MTX remains very useful in severe psoriasis, to some extent, in various dermatological diseases, such as dermatomyositis. A perfect knowledge of its adverse effects (slight on the gastrointestinal tract and bone marrow, much more serious on the liver and lung) allows a reasonable use of the drug but cannot avoid the unpredictable hypersensitivity pneumopathy.
Plantin
P
P
Service de dermatologie, CHU Brest.
Saraux
A
A
Guillet
G
G
D000014:Abnormalities, Drug-Induced; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006402:Hematologic Diseases / Q000139:chemically induced; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D011247:Pregnancy; D012871:Skin Diseases / Q000188:drug therapy*
D008727:Methotrexate
Méthotrexate en dermatologie: aspects actuels.