[Mast cell and blood coagulation functions during prolonged noradrenaline administration].
During the long term noradrenaline injection (0.56 microgram/kg/min-2 hours during six days) the number of connective tissue mast cells decreases in dogs. Mature cells disappears and the percentage of young forms increases. Marked degranulation develops. 5-10 cell groups and chains are formed. The increase of free heparin level and the activation of anticoagulant unit hemostasis correspond to these changes. It is due to mast cells discharge of biologically active heparin which is an unspecific adaptogen.
Frolenko
V I
VI
Isabaeva
V A
VA
Zakharov
G A
GA
Gorokhova
G I
GI
Novikova
N P
NP
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D002452:Cell Count / Q000187:drug effects; D004285:Dogs; D008407:Mast Cells / Q000187:drug effects* / Q000502:physiology; D009638:Norepinephrine / Q000008:administration & dosage*; D012867:Skin / Q000166:cytology / Q000187:drug effects; D013997:Time Factors
D009638:Norepinephrine
Sostoianie tuchnykh kletok i gemokoaguliatsii pri dlitel'nom vvedenii noradrenalina.