[Pharmacokinetics of intravenous anesthetics in aged patients].
This paper reviews the pharmacokinetic modifications of anaesthetic intravenous drugs in elderly reported in the literature. With benzodiazepines, the elimination half-life is prolonged and can increase the duration of the sedative effect. With hypnotics, the increase of pharmacological effect (intensity and duration) is due to a decrease of initial volume of distribution and total body clearance. Except morphine, the pharmacokinetic of opioids is slightly changed and can't explain the increase of the pharmacodynamic sensibility.
Levron
J C
JC
Marchetti
F
F
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000493:pharmacokinetics*; D006801:Humans; D008875:Middle Aged
D000777:Anesthetics
Pharmacocinétique des anesthésiques intra-veineux chez le sujet âgé.