title: Changes in serum phosphate during beta-blockade in healthy men are not due to changes in the renal handling of phosphate.
abstract: Serum parathyroid hormone (PTH), phosphate, ionized calcium, magnesium, alkaline phosphatase and creatinine and the urinary excretion of phosphate and creatinine were studied after 1 and 3 weeks beta-blockade in 32 young healthy men given either atenolol at 50 mg, metoprolol at 100 mg, propranolol at 80 mg or placebo twice a day. After 1 week treatment serum phosphate (mean (range] increased in the propranolol-treated subjects (1.17 (0.99-1.30) to 1.32 (1.08-1.71) mmol l-1 (P = 0.03), minor changes were found in the atenolol and the metoprolol-treated subjects but not in the placebo group. Serum phosphate was unchanged compared to pretreatment values after 3 weeks. Renal clearance and urinary excretion of phosphate and creatinine was unchanged after both 1 and 3-weeks treatment. Serum PTH, ionized calcium, magnesium and alkaline phosphatase were unchanged in all groups, whereas serum urate and creatinine increased in the metoprolol-treated subjects after both 1 and 3 weeks.
authors.affiliation: Department of Internal Medicine and Endocrinology F, Herlev Hospital, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Kayser
authors.forename: H
authors.initials: H
authors.lastname: Perrild
authors.forename: B
authors.initials: B
authors.lastname: Jørgensen
authors.forename: N
authors.initials: N
authors.lastname: Fogh-Andersen
authors.forename: J E
authors.initials: JE
authors.lastname: Mølholm Hansen
mesh_terms: D000328:Adult; D001262:Atenolol / Q000097:blood*; D002986:Clinical Trials as Topic; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008297:Male; D008790:Metoprolol / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood*; D011433:Propranolol / Q000097:blood*; D011897:Random Allocation
chemical_list: D010281:Parathyroid Hormone; D010710:Phosphates; D001262:Atenolol; D011433:Propranolol; D008790:Metoprolol