title: Cytogenetic abnormalities in a secondary lymphoma complicating cardiac transplantation.
abstract: We report a case of secondary lymphoma in the brain in a cardiac transplant recipient. Cytogenetic analysis revealed the presence of clonal cytogenetic abnormalities. Two clones with unrelated chromosomal abnormalities were noted; in both abnormal clones, trisomy for the long arm of chromosome 11 was observed. Our observations, combined with single cases previously reported, suggest that a gain of the long arm of chromosome 11 may represent a characteristic cytogenetic abnormality that is associated with secondary lymphoma.
authors.affiliation: Department of Medicine, University of Chicago Hospital and Clinic, Illinois.
authors.forename: O L
authors.initials: OL
authors.lastname: Olopade
authors.forename: J
authors.initials: J
authors.lastname: Anastasi
authors.forename: M
authors.initials: M
authors.lastname: Thangavelu
authors.forename: M M
authors.initials: MM
authors.lastname: Le Beau
authors.forename: H M
authors.initials: HM
authors.lastname: Golomb
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000209:etiology / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D008223:Lymphoma / Q000209:etiology / Q000235:genetics*; D014314:Trisomy