[Comparative study of the administration of amikacin by intramuscular and intravenous routes in neonatal resuscitation].
A study was carried out to determine amikacin blood levels in 44 neonates who were admitted to a Pediatric Intensive Care Unit. Amikacin was administered by intravenous or intramuscular route. The levels obtained with both methods were similar. The results of our study indicate that amikacin levels should be monitored in neonates to avoid toxic concentrations of this drug. On the basis of this study a new neonatal dosage schedule is proposed.
Deramoudt-Dutrus
V
V
Département d'anesthésie-réanimation, CHR, Rennes, France.
Betremieux
P
P
Lefrançois
C
C
Malledant
Y
Y
Avril
J L
JL
Le Marec
B
B
D000583:Amikacin / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D001424:Bacterial Infections / Q000097:blood / Q000188:drug therapy*; D004423:Ear / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007363:Intensive Care Units, Neonatal; D007668:Kidney / Q000187:drug effects; D011446:Prospective Studies
D000583:Amikacin
Etude comparative de l'administration de l'amikacine par voie intramusculaire et intraveineuse en réanimation néo-natale.