title: Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid.
abstract: Cytokines play an important role not only for initiation of immune reactivity but also for development of tissue injury. Of 38 patients infected with human immunodeficiency virus type 1 (HIV-1) interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) were identified in cerebrospinal fluid (CSF) of 22 (58%) and 16 (42%) patients, respectively. Among the IL-1 beta- and IL-6-positive CSF were eight of 15 HIV-1 patients with no clinical signs of central nervous system involvement and four of five patients with acquired immunodeficiency syndrome (AIDS) dementia complex. The presence of IL-6 was often associated with IL-1 beta and soluble interleukin-2 receptor in CSF as well as with intrathecal IgG synthesis. In none of the CSF samples tumor necrosis factor-alpha or interleukin-2 was detected.
authors.affiliation: Institute of Neurology, University of Padova, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Gallo
authors.forename: K
authors.initials: K
authors.lastname: Frei
authors.forename: C
authors.initials: C
authors.lastname: Rordorf
authors.forename: J
authors.initials: J
authors.lastname: Lazdins
authors.forename: B
authors.initials: B
authors.lastname: Tavolato
authors.forename: A
authors.initials: A
authors.lastname: Fontana
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid* / Q000150:complications; D001685:Biological Factors / Q000134:cerebrospinal fluid*; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000150:complications / Q000209:etiology; D016207:Cytokines; D003704:Dementia / Q000209:etiology; D015497:HIV-1; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007375:Interleukin-1 / Q000134:cerebrospinal fluid; D015850:Interleukin-6; D007378:Interleukins / Q000134:cerebrospinal fluid
chemical_list: D001685:Biological Factors; D016207:Cytokines; D007074:Immunoglobulin G; D007375:Interleukin-1; D015850:Interleukin-6; D007378:Interleukins