[Monoclonal antibodies and uveal melanomas].
The authors, who have succeeded since 1976 in cultivating cells of ocular melanoma in continuous lines report the different stages for producing specific monoclonal antibodies. They particularly insist on the demonstration, through radioimmunoassay, of the specificity of marked monoclonal antibodies, on the immunohistochemical study and on biodistribution. From these data, an immunotherapy protocol has been perfected and starts being applied to human beings.
Le Rebeller
M J
MJ
Safi
N
N
Larson
S
S
Beba
R
R
Kantor
R
R
Donoso
L
L
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis* / Q000276:immunology; D000918:Antibody Specificity; D005260:Female; D006825:Hybridomas / Q000276:immunology / Q000378:metabolism; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D008545:Melanoma / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D014407:Tumor Cells, Cultured; D014604:Uveal Neoplasms / Q000276:immunology* / Q000378:metabolism
D000911:Antibodies, Monoclonal
Anticorps monoclonaux et mélanomes uvéaux.