title: Lymphokine activated killer (LAK) activity in lymphoproliferative disorders.
abstract: Lymphokine activated killer (LAK) cells are being considered as a new and promising form of immunotherapy in the management of patients with solid tumours. Few informations are instead available on these cytotoxic effectors in haematological neoplasias. Here we shall discuss the possible role of LAK cells in human leukaemias. Evidence will be provided for a rationale in the clinical exploitment of Interleukin 2 (IL2)/LAK cells in the treatment of acute leukaemia patients, whilst the implication of these cytotoxic populations appears more uncertain in chronic lymphoproliferative disorders.
authors.affiliation: Dipartimento di Scienze Biomediche e Oncologia Umana, University of Torino, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Foa
authors.forename: M T
authors.initials: MT
authors.lastname: Fierro
authors.forename: D
authors.initials: D
authors.lastname: Raspadori
authors.forename: M
authors.initials: M
authors.lastname: Bonferroni
authors.forename: S
authors.initials: S
authors.lastname: Cardona
authors.forename: X S
authors.initials: XS
authors.lastname: Liao
authors.forename: A
authors.initials: A
authors.lastname: Cesano
authors.forename: L
authors.initials: L
authors.lastname: Matera
authors.forename: A
authors.initials: A
authors.lastname: Gillio Tos
authors.forename: E
authors.initials: E
authors.lastname: Tola
mesh_terms: D003602:Cytotoxicity, Immunologic; D005069:Evaluation Studies as Topic; D006801:Humans; D007116:Immunization, Passive; D007167:Immunotherapy; D007376:Interleukin-2 / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000276:immunology / Q000637:transplantation*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008232:Lymphoproliferative Disorders / Q000628:therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy
chemical_list: D007376:Interleukin-2