title: New insights into the nature and heterogeneity of mood disorders.
abstract: Emerging research findings in mood disorders continue to provide support for multifactorial etiology. The present review considers the role of familial and developmental factors, gender, life circumstances, and biological precipitants in pathogenesis and discusses how they might, hypothetically, interact with other psychological and biological traits in giving rise to clinical heterogeneity. Special consideration is given to the pathoplastic influence of characterologic and temperamental traits, in view of their current clinical visibility.
authors.affiliation: Department of Psychiatry, University of Tennessee, Memphis 38163.
authors.forename: H S
authors.initials: HS
authors.lastname: Akiskal
mesh_terms: D000328:Adult; D000367:Age Factors; D002648:Child; D003866:Depressive Disorder / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D005260:Female; D006380:Helplessness, Learned / Q000523:psychology; D006801:Humans; D008016:Life Change Events; D008297:Male; D019964:Mood Disorders / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D012701:Serotonin / Q000502:physiology; D012737:Sex Factors; D013694:Temperament
chemical_list: D012701:Serotonin