[DNA modification and carcinogenesis--early events caused by a heterocyclic aromatic amine, Glu-P-1].
Isolation, structure and activity of a mutagen, 2-amino-6-methyldipyrido [1, 2-a: 3', 2'-d] imidazole (Glu-P-1), were summarized. The metabolic activation, its specific reaction with DNA and biomimetic mutation of proto-ras oncogene were described.
Shudo
K
K
Faculty of Pharmaceutical Sciences, University of Tokyo.
Hashimoto
Y
Y
D000818:Animals; D001483:Base Sequence; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000187:drug effects* / Q000235:genetics; D004249:DNA Damage; D011905:Genes, ras / Q000187:drug effects; D007093:Imidazoles / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000633:toxicity*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009153:Mutagens / Q000493:pharmacokinetics / Q000633:toxicity; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000235:genetics
D007093:Imidazoles; D009153:Mutagens; C023785:2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole; D004247:DNA