[Experimental studies on stress hormones at the time of sudden death (II)--Differences in adrenocortical hormone levels of cardiac arrest-preceding type and apnea preceding type sudden death under cerebral ischemia or aortic stenosis].
Under cerebral ischemia or aortic stenosis, changes in plasma and adrenal corticosterone (CS) levels before and after cardiac arrest-preceding type (CPT) and apnea-preceding type (APT) sudden death were examined to determine the response of the hypophyseal adrenocortical system in Wistar rats. The plasma CS value at 1.5 hours after cerebral ischemia treatment was about 3 times that of pretreatment under non-anesthesia. With the occurrence of CPT and APT sudden death during cerebral ischemia, a difference between CS levels before and after death was more pronounced in the adrenals than in the plasma. The adrenal CS value after death was significantly lower than that before death in APT sudden death (P less than 0.05), though the CS value in adrenals after death was the same as that of living animals with cerebral ischemia in CPT sudden death. APT sudden death may thus be concluded to have a lower CS level in the adrenals than CPT sudden death (P less than 0.01). In the case of aortic stenosis, the effect of this treatment on plasma CS level was not as distinct as in the case of cerebral ischemia. Only a slight increase in plasma CS was noted on the 6th day from treatment. Under this condition, a difference between plasma or adrenal CS levels before and after CPT and APT sudden death was similar to the case of cerebral ischemia. The adrenal CS value after death in both sudden death types was also the same case of cerebral ischemia.(ABSTRACT TRUNCATED AT 250 WORDS)
Tsunoda
K
K
Douge
K
K
Ming-Chang
T
T
Watanabe
T
T
D000311:Adrenal Glands / Q000503:physiopathology*; D000818:Animals; D001024:Aortic Valve Stenosis / Q000150:complications* / Q000503:physiopathology; D001049:Apnea / Q000209:etiology*; D002545:Brain Ischemia / Q000150:complications* / Q000503:physiopathology; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D003645:Death, Sudden / Q000209:etiology*; D006323:Heart Arrest / Q000209:etiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003345:Corticosterone