Determination of an appropriate size of unrelated donor pool to be registered for HLA-matched bone marrow transplantation.
HLA-matched bone marrow transplantation from related or unrelated donors appears to be effective. To supply HLA-matched bone marrow for patients who do not have HLA-matched family donors, registration of unrelated HLA-typed donors and selection of matched donors will be necessary. In this study, the frequencies of each possible HLA phenotype and of corresponding, potentially matched donors were calculated by a computer from the table of frequencies of HLA-A, -B, and -DR haplotypes using data from 300 families in Japan and from the Eighth International Histocompatibility Workshop for European and North American whites. Appropriate sizes of such donor pools were evaluated theoretically in the Japanese population and in European and North American whites. To enable more than 80 percent of patients to have at least one identical donor, only 50,000 potential donors would be necessary for Japanese persons, whereas 1,000,000 and 400,000, respectively, would be required for European and North American whites.
Takahashi
K
K
Blood Transfusion Service, Tokyo University, Japan.
Juji
T
T
Miyazaki
H
H
D001782:Blood Donors; D016026:Bone Marrow Transplantation; D005060:Europe; D005190:Family; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D007564:Japan; D009656:North America; D012042:Registries
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens