The antioxidative properties of thiazolidine derivatives.
Antioxidative properties of thiazolidine compounds, adducts of L-cysteine with formaldehyde (thiazolidine-4-carboxylic acid), with pyruvate (2-methyl-thiazolidine-2,4-dicarboxylic acid), and glucose (2-/D-gluco-1',2',3',4',5'-penthahydroxypentyl/- thiazolidine-4-carboxylic acid) were studied. The investigated compounds, as well as L-cysteine and DL-penicillamine inhibited in vitro lipid peroxidation induced by NADPH, ethanol, and hydrogen peroxide in the suspension of rat liver microsomes.
Włodek
L
L
Institute of Medical Biochemistry, Copernicus Medical Academy, Kraków, Poland.
Czubak
J
J
D000818:Animals; D000975:Antioxidants; D000431:Ethanol / Q000494:pharmacology; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology*
D000975:Antioxidants; D013844:Thiazoles; D000431:Ethanol; D009249:NADP