title: Coupling growth arrest and adipocyte differentiation.
abstract: The complete differentiation program of preadipose cells can be divided into early and late events. The expression of early markers takes place at growth arrest (G1/S boundary), whereas that of late markers, leading to terminal differentiation, takes place after a limited number of mitoses of early marker-containing cells. Only terminal differentiation requires the presence of growth hormone and triiodothyronine and results in the formation of triacylglycerol-filled, nondividing cells. The events of adipose cell differentiation which take place in vitro allow a better understanding of the development of adipose tissue in vivo.
authors.affiliation: Centre de Biochimie du CNRS, Université de Nice, France.
authors.forename: G
authors.initials: G
authors.lastname: Ailhaud
authors.forename: C
authors.initials: C
authors.lastname: Dani
authors.forename: E Z
authors.initials: EZ
authors.lastname: Amri
authors.forename: P
authors.initials: P
authors.lastname: Djian
authors.forename: C
authors.initials: C
authors.lastname: Vannier
authors.forename: A
authors.initials: A
authors.lastname: Doglio
authors.forename: C
authors.initials: C
authors.lastname: Forest
authors.forename: D
authors.initials: D
authors.lastname: Gaillard
authors.forename: R
authors.initials: R
authors.lastname: Négrel
authors.forename: P
authors.initials: P
authors.lastname: Grimaldi
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D005993:Glycerolphosphate Dehydrogenase / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D066298:In Vitro Techniques; D007328:Insulin / Q000502:physiology; D013234:Stem Cells / Q000166:cytology; D014284:Triiodothyronine / Q000502:physiology
chemical_list: D006133:Growth Substances; D007328:Insulin; D014284:Triiodothyronine; D005993:Glycerolphosphate Dehydrogenase