Methemoglobin toxicity and hematological studies on malaria anti-relapse compound CDRI 80/53 in dogs.
Methemoglobin toxicities of primaquine and compound N1-(3-acetyl-4-5-dihydro-2-furanyl)-N4-(6-methoxy-8-quinolinyl) 1,4-pentanediamine, CDRI Code 80/53, have been compared in beagles. Primaquine administration at 3 mg/kg for 7 days produced significantly high (P less than 0.001) methemoglobinemia and the levels increased 10.55-fold. Compound 80/53 at 3.75 mg/kg x 7 days produced a marginal increase in methemoglobinemia (3.24-fold; P less than 0.02). The methemoglobin formed by primaquine administration was 3.65-fold (P less than 0.001) higher than that formed after administration of compound 80/53. There was no significant change in other hematological parameters and liver function tests.
Puri
S K
SK
Division of Microbiology, Central Drug Research Institute, Lucknow, India.
Srivastava
R
R
Pandey
V C
VC
Sethi
N
N
Dutta
G P
GP
D000634:Aminoquinolines / Q000633:toxicity*; D000818:Animals; D000962:Antimalarials / Q000633:toxicity*; D001066:Appetite / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004285:Dogs; D005260:Female; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced*; D011319:Primaquine / Q000633:toxicity* / Q000031:analogs & derivatives
D000634:Aminoquinolines; D000962:Antimalarials; D011319:Primaquine; C063469:bulaquine