Expression of MHC class I and II antigens by keratinocytes and enterocytes in acute graft-versus-host disease. Newcastle Bone Marrow Transplant Group.
The expression of MHC class I and subgroups of class II antigens by keratinocytes and enterocytes has been investigated in patients receiving autologous and allogeneic bone marrow transplants. Allogeneic recipients with graft-versus-host disease (GVHD) expressed all the class II antigens HLA DR, DP and DQ more frequently than pretransplant patients, autologous or allogeneic recipients without GVHD post-BMT (p less than 0.01). Staining for DP and DQ was never detected without DR being present. Whenever there was a lymphocytic infiltrate in the epidermis or single cell necrosis in the gut, DR was expressed on the epithelium. There was no difference in class I expression in GVHD. This study further increases the immunopathological characterization of acute GVHD which may improve the understanding of its pathogenesis.
Sviland
L
L
Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Pearson
A D
AD
Green
M A
MA
Eastham
E J
EJ
Malcolm
A J
AJ
Proctor
S J
SJ
Hamilton
P J
PJ
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D006086:Graft vs Host Disease / Q000276:immunology* / Q000473:pathology; D006680:HLA Antigens; D006681:HLA-D Antigens; D006801:Humans; D008875:Middle Aged; D012007:Rectum / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000276:immunology / Q000473:pathology; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
D006680:HLA Antigens; D006681:HLA-D Antigens