Genotoxic effects of niclosamide in Aspergillus nidulans.
A 2-5-month treatment with niclosamide, a widely used drug in developing countries, has been reported to induce lymphosarcomas in toad liver and kidney. The genotoxic effects of this drug have also been evaluated in Salmonella typhimurium, in somatic and germinal cells of mice and in human lymphocytes exposed in vitro and in vivo. The present study shows that niclosamide is also capable of inducing mitotic crossing-over and non-disjunction in Aspergillus nidulans, which points to the wide potential of this drug as a genotoxic agent.
de la Torre
R A
RA
Facultad de Biología, Universidad de La Habana, Cuba.
de la Rúa Barceló
R
R
Hernández
G
G
Espinosa
J J
JJ
Cortinas de Nava
C
C
D001233:Aspergillus nidulans / Q000187:drug effects* / Q000235:genetics; D001711:Biotransformation; D003434:Crossing Over, Genetic / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects; D009152:Mutagenicity Tests; D009534:Niclosamide / Q000378:metabolism / Q000633:toxicity*; D009630:Nondisjunction, Genetic / Q000187:drug effects
D009534:Niclosamide