Bleeding prophylaxis in autologous bone marrow transplantation for solid tumors. Comparison of cryopreserved autologous and fresh allogeneic single-donor platelets.
Bleeding prophylaxis with cryopreserved autologous thrombocytes was evaluated in 43 patients treated with high-dose chemotherapy and autologous bone marrow transplantation. Platelet transfusions were given prophylactically. Nineteen patients received only autologous, 10 only fresh allogeneic single-donor, and 14 both types of transfusions. The effects of 104 autologous versus 93 allogeneic thrombocyte transfusions were compared. The increment at 1 h was for allogeneic platelets twice that for autologous platelets (30.6 versus 15.2 x 10(9)/l), but the interval between transfusions in days (2.3) was the same. Twelve patients received alternating autologous platelet transfusion after washing out the cryoprotectant dimethyl sulfoxide (18 transfusions) and non-washed autologous platelets (24 transfusions). Platelet increments, corrected increments, and predicted recovery were not influenced by omitting the washing procedure, and no side effects of dimethyl sulfoxide occurred.
Mulder
P O
PO
Department of Internal Medicine, State University Hospital, Groningen, The Netherlands.
Maas
A
A
de Vries
E G
EG
Orie
J L
JL
Sleijfer
D T
DT
Smit Sibinga
C T
CT
Willemse
P H
PH
Mulder
N H
NH
D000328:Adult; D000368:Aged; D001793:Blood Preservation; D001804:Blood Transfusion, Autologous; D016026:Bone Marrow Transplantation; D004121:Dimethyl Sulfoxide; D005260:Female; D005615:Freezing; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D017713:Platelet Transfusion
D004121:Dimethyl Sulfoxide