[Effect of long-term treatment with propranolol or hydrochlorothiazide on biochemical risk factors of coronary disease in patients with hypertension].
In 59 patients with mild or moderate essential hypertension effects of propranolol and hydrochlorothiazide on serum lipids, fibrynogen, glucose and uric acid concentrations as well as serum euglobulins fibrynolysis time were studied. 36 patients received propranolol and 23 subjects hydrochlorothiazide. Follow-up time was 1 year. Statistically significant increases of serum triglycerides, fibrynogen, levels and total cholesterol/HDL cholesterol LDH/HDL indices in comparison with their initial values were stated in a propranolol group. Significant serum cholesterol increase after 6 month therapy was the most substantial metabolic change in a hydrochlorothiazide group. Alterations of lipids indices in both groups were especially intensive in patients with pretreatment stated disturbances of lipids metabolism.
Witkowska
M
M
Lukasik
S
S
Kawecka
M
M
Moszczyńska
J
J
Karolko
B
B
D000328:Adult; D003327:Coronary Disease / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000633:toxicity*; D006937:Hypercholesterolemia / Q000139:chemically induced* / Q000150:complications; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D015228:Hypertriglyceridemia / Q000139:chemically induced* / Q000150:complications; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors; D013997:Time Factors
D008055:Lipids; D006852:Hydrochlorothiazide; D011433:Propranolol
Wpływ prezewlekłego leczenia propranololem lub hydrochlorotiazydem na biochemiczne czynniki zagrozenia choroba wieńcowa u chorych na nadcisnienie tetnicze krwi.