Favorable effects of prostacyclin infusion in a patient given a renal transplant and with severe vascular disease secondary to diabetes--a case report.
Microangiopathy is one of the most frequent diseases in diabetic patients. A diabetic man with a kidney transplant and with severe and progressive vasculopathy with early necrosis of the fingers and toes was submitted to three prostacyclin (PGI2) intravenous infusions (5 ng/kg/min for forty-eight hours) during a period of two months. Three months after the last infusion, radiographs of the hands and feet showed a marked reduction in the extent of the vascular calcifications and healing of the ischemic-necrotic areas. The authors discuss the immediate and later effects of PGI2 infusion in a case of diabetic vascular disease.
Bedani
P L
PL
Division of Nephrology, S. Anna Hospital, Ferrara, Italy.
Fiocchi
O
O
Soffritti
S
S
Farinelli
A
A
D000328:Adult; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000188:drug therapy; D003925:Diabetic Angiopathies / Q000188:drug therapy*; D011464:Epoprostenol / Q000627:therapeutic use*; D005528:Foot / Q000098:blood supply; D006225:Hand / Q000098:blood supply; D006801:Humans; D007262:Infusions, Intravenous; D016030:Kidney Transplantation; D008297:Male; D011859:Radiography
D011464:Epoprostenol