Inhibitory effect of the C-terminal octapeptide of oxyntomodulin on pentagastrin-stimulated gastric acid secretion in man.
The effect of the C-terminal octapeptide of human oxyntomodulin (KA-8) on pentagastrin-stimulated gastric acid secretion was studied versus placebo in eight human volunteers after an overnight fast, using a double-blind randomized protocol. KA-8 (7.5 nmol/kg body weight) was bolus-injected at a plateau stimulation obtained with pentagastrin (3 micrograms/kg/h). KA-8 significantly decreased the volume secreted by 36% (p less than 0.025) and the acid output by 32% (p less than 0.025) 20 min after injection. The areas under the curve were significantly reduced for volume and acid output during the 1st h after peptide injection.
Veyrac
M
M
Digestive Diseases Dept., Hôpital Saint-Eloi, Montpellier, France.
Ribard
D
D
Daures
J P
JP
Mion
H
H
Lequellec
A
A
Martinez
J
J
Bataille
D
D
Michel
H
H
D000328:Adult; D000595:Amino Acid Sequence; D004311:Double-Blind Method; D005744:Gastric Acid / Q000378:metabolism*; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D004763:Glucagon-Like Peptides / Q000494:pharmacology*; D006801:Humans; D008297:Male; D053772:Oxyntomodulin; D010418:Pentagastrin / Q000494:pharmacology*; D010446:Peptide Fragments; D016032:Randomized Controlled Trials as Topic; D012636:Secretory Rate / Q000187:drug effects; D013997:Time Factors
D005768:Gastrointestinal Hormones; D053772:Oxyntomodulin; D010446:Peptide Fragments; D004763:Glucagon-Like Peptides; D010418:Pentagastrin