title: Asymmetric synthesis of 2-substituted-3-aminocarbonyl propionic acid.
abstract: An asymmetric synthetic route to 2-substituted-3-aminocarbonyl propionic acid, which is the significant component of low-molecular-weight renin inhibitors, is described. The key step of this synthesis is diastereoselective alkylation by using chiral oxazolidinone and benzyl bromoacetate.
authors.forename: T
authors.initials: T
authors.lastname: Nishi
authors.forename: M
authors.initials: M
authors.lastname: Sakurai
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Kataoka
authors.forename: Y
authors.initials: Y
authors.lastname: Morisawa
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D011422:Propionates / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D000092502:Renin Inhibitors
chemical_list: D011422:Propionates; D000092502:Renin Inhibitors