[Interpretation of the influence of immunoglobulins and glycine on bacterial sensitivity to antibiotics in vitro].
The effect of human immunoglobulins (Ig) and of glycine, often added to commercial preparations as a stabilizer, have been examined in vitro on the growth of E. coli strains in the absence or presence of antibiotics in subminimal inhibitory concentrations (subMic). The Ig's (= 7S or 5S = F(ab')2 as well as glycine had no effect by themselves on bacterial growth at concentrations up to 32 mg and 4.5 mg per ml respectively. In contrast, in the presence of ampicillin, glycine induced a concentration dependent increase of bacterial sensitivity to antibiotics. This is apparently more pronounced in serosensitive than in seroresistant E. coli strains. Such a synergism could equally be shown with cefadroxil and fosfomycin, i.e. with other antibiotics interacting with cell wall synthesis, but not with those of another mode of action, as ciprofloxacin, polymyxin B or chloramphenicol.
Gillissen
G
G
Institut de Microbiologie Médicale, Faculté de Médecine, Université d'Aix-la-Chapelle.
Melzer
B
B
Breuer-Werle
M
M
D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004926:Escherichia coli / Q000145:classification / Q000187:drug effects*; D005998:Glycine / Q000008:administration & dosage / Q000494:pharmacology*; D007136:Immunoglobulins; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D007136:Immunoglobulins; D000667:Ampicillin; D005998:Glycine
Interprétation de l'influence des immunoglobulines et de la glycine sur la sensibilité des bactéries aux antibiotiques in vitro.