[The effect of nerobol and ecdysterone on insulin-dependent processes linked normally and in insulin resistance].
The effect of substances with anabolic activity (metandienone and ecdysterone phytoecdysteroid) on the manifestation of insulin effects was studied on a model of insulin resistance in rats induced by injections of hydrocortisone or by insulin insufficiency caused by alloxan. The sensitivity of the body to i. v. infusion of insulin and the reactivity of isolated fatty tissue to the hormone were increased after administration of these substances to test animals. The above effects of steroids were determined by nonspecific synthesis of total proteins in cells rather than by an increase in insulin secretion.
Kosovskiĭ
M I
MI
Syrov
V N
VN
Mirakhmedov
M M
MM
Katkova
S P
SP
Khushbaktova
Z A
ZA
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D004347:Drug Interactions; D004441:Ecdysterone / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D006854:Hydrocortisone; D007328:Insulin / Q000494:pharmacology*; D007333:Insulin Resistance / Q000502:physiology*; D008066:Lipolysis / Q000187:drug effects / Q000502:physiology; D008297:Male; D008696:Methandrostenolone / Q000494:pharmacology*; D051379:Mice; D014176:Protein Biosynthesis; D011506:Proteins / Q000187:drug effects; D051381:Rats
D000596:Amino Acids; D007328:Insulin; D011506:Proteins; D004441:Ecdysterone; D008696:Methandrostenolone; D005947:Glucose; D006854:Hydrocortisone
Vliianie nerobola i ékdisterona na nekotorye sviazannye insulinzavisimye protsessy v norme i pri insulinorezistentnosti.