Effects of complex experience on somatic growth and organ development in rats.
Rats kept in complex environments (EC) show an array of brain changes relative to animals housed individually (IC). These effects have been explained as due to (a) information storage, (b) chronic stress that causes brain damage, or (c) neuroendocrine effects on brain maturation. Complex experience also affects somatic growth and organ development, and these may be related to the EC/IC brain differences. We have compared somatic growth and internal organs of 315 weanling and adult rats with various histories. (a) Young EC rats showed slower skeletal and visceral growth, while many brain components expand. (b) Although thymus and spleen were lighter in young ECs, immunocompetence was nonsignificantly (p less than .07) higher than in ICs. (c) Somatic growth of adult rats was slow and not very responsive to experience, whereas studies have shown EC/IC brain effects similar to those in young rats. (d) Males had slightly greater EC/IC somatic and visceral differences. (e) The stress index, adrenal weight, varied across age and experience, so chronic stress can not explain EC/IC brain differences. Training paradigms show brain changes similar to those from complex experience, occurring specifically with learning and in brain regions using the information. Learning and memory, therefore remain the best explanation of the EC brain effects.
Black
J E
JE
College of Medicine, University of Illinois, Urbana-Champaign.
Sirevaag
A M
AM
Wallace
C S
CS
Savin
M H
MH
Greenough
W T
WT
D000311:Adrenal Glands / Q000254:growth & development; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D001835:Body Weight / Q000502:physiology*; D001846:Bone Development; D001842:Bone and Bones / Q000033:anatomy & histology; D001921:Brain / Q000254:growth & development*; D005260:Female; D007668:Kidney / Q000254:growth & development; D007858:Learning / Q000502:physiology*; D008099:Liver / Q000254:growth & development; D008297:Male; D008568:Memory / Q000502:physiology*; D009929:Organ Size; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics; D013154:Spleen / Q000254:growth & development; D013312:Stress, Physiological / Q000150:complications*; D013950:Thymus Gland / Q000254:growth & development; D013997:Time Factors