Twenty-four hour excretion of urinary C-peptide in gestational diabetic women before and after treatment with diet or diet and insulin.
24-h urinary C-peptide excretion was studied in 119 women with gestational diabetes before and after treatment with diet or diet and insulin. The 24-h urinary C-peptide excretion in normal-weight gestational diabetic women at diagnosis was also compared to that of a healthy reference group. There was a wide variation in urinary C-peptide values which tended to be higher in normal-weight women with gestational diabetes at diagnosis compared to the reference group, but it did not reach statistical significance. Post partum gestational diabetic women had significantly higher urinary C-peptide excretion (p less than 0.002) than the reference group, indicating insulin resistance in women with gestational diabetes at this time. In 29 overweight women with gestational diabetes 24-h urinary C-peptide excretion did not significantly differ from that in normal-weight women with gestational diabetes. In 32 women with a more marked deviation in glucose tolerance (area greater than or equal to 46 mmol/l) 24-h urinary C-peptide values were significantly (p less than 0.05) higher than in 58 women with gestational diabetes with an area between 42 and 45.9 mmol/l. Both treatment alternatives, diet and diet plus insulin, significantly reduced postprandial blood glucose values (p less than 0.05) and urinary C-peptide excretion was significantly decreased (p less than 0.05).
Nordlander
E
E
Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden.
Hanson
U
U
Stangenberg
M
M
Persson
B
B
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000652:urine*; D003920:Diabetes Mellitus / Q000652:urine*; D003927:Diet, Diabetic; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D009765:Obesity; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000178:diet therapy / Q000188:drug therapy / Q000652:urine*; D012016:Reference Values
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin