title: Protein and energy metabolism during prolonged exercise in trained athletes.
abstract: Eight elite triathlon athletes participated in a laboratory study of the effects of endurance exercise on protein and energy metabolism. The study consisted of 3 h of cycling and 5 h of treadmill running; 3.5 h before beginning the exercise, a primed constant infusion of 1-13C leucine and 6,6(-2)H glucose was begun. Serial blood samples were collected during the rest and exercise periods for isotopic analysis. Respiratory gas exchange was determined every half hour.
  
  
  RESULTS
  the subjects exercised at an average of 53% +/- 3% of peak VO2. During the 8-h exercise period there was a decline in glucose utilization and an increase in lipid oxidation. For the first part of the exercise, most of the glucose oxidized was of muscle origin. Hepatic glucose production increased with exercise from 20 g/h to a maximum of about 60 g/h after 4 h of exercise and then decreased toward the pre-exercise rate. The plasma urea concentration was unchanged during the study. The leucine flux decreased during the first 4 h of exercise and then attained a new plateau about 20% lower than the pre-exercise value indicating an adaptive reduction in protein turnover.
authors.affiliation: Dept. of Surgery, Univ. of Medicine & Dentistry, New Jersey-School of Osteopathic Medicine, Camden.
authors.forename: T P
authors.initials: TP
authors.lastname: Stein
authors.forename: R W
authors.initials: RW
authors.lastname: Hoyt
authors.forename: M O
authors.initials: MO
authors.lastname: Toole
authors.forename: M J
authors.initials: MJ
authors.lastname: Leskiw
authors.forename: M D
authors.initials: MD
authors.lastname: Schluter
authors.forename: R R
authors.initials: RR
authors.lastname: Wolfe
authors.forename: W D
authors.initials: WD
authors.lastname: Hiller
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000097:blood; D001642:Bicycling; D001786:Blood Glucose / Q000378:metabolism; D002986:Clinical Trials as Topic; D004734:Energy Metabolism; D015444:Exercise; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007930:Leucine / Q000097:blood / Q000378:metabolism*; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D010806:Physical Education and Training; D010807:Physical Endurance; D011659:Pulmonary Gas Exchange; D012420:Running
chemical_list: D000596:Amino Acids; D001786:Blood Glucose; D007930:Leucine; D005947:Glucose