[Effects of therapy and pregnancy on hyperprolactemia caused by a pituitary adenoma. A clinical case].
A woman who presented with amenorrhea and galactorrhea with a large prolactinoma (8.5 mm) which regressed on bromocriptine therapy is described. When treatment with bromocriptine was instituted (10 mg/daily) mean serum prolactin concentration fell from 490 ng/ml to 108 ng/ml. Despite a progressive reduction in size up to disappearance of the adenoma after the first 5 years of therapy, prolactin levels remained high. Bromocriptine treatment was stopped after 6 years, when pregnancy was diagnosed. Pregnancy proceeded without complications and lactation was initiated and maintained. After 8 months of breast-feeding, menstrual function resumed spontaneously and bromocriptine therapy was no longer required. Bromocriptine can cause not only a decrease in serum prolactin levels but also a regression in the size of prolactinomas in hyperprolactinemic women. No problems associated with pregnancy and/or breast-feeding were noted in these patients.
Pasinetti
E
E
Schivardi
M R
MR
Falsetti
L
L
Gastaldi
A
A
D000328:Adult; D000568:Amenorrhea / Q000209:etiology; D001971:Bromocriptine / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D005687:Galactorrhea / Q000209:etiology; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D010911:Pituitary Neoplasms / Q000150:complications / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000188:drug therapy*; D011388:Prolactin / Q000097:blood; D015175:Prolactinoma / Q000097:blood / Q000150:complications / Q000188:drug therapy*
D001971:Bromocriptine; D011388:Prolactin
Effetti della terapia e della gravidanza nella iperprolattinemia da adenoma ipofisario. Caso clinico.