Surgical versus medical treatment of nasal polyps.
Surgical removal of nasal polyps is associated with discomfort and risks for the patient, but is the treatment of choice to most otorhinolaryngologists. Medical treatment alone has been little investigated. In a prospective clinical trial surgical removal followed by continuous topical steroid treatment has been compared with a single dose of steroid deposit followed by continuous topical steroid treatment. During a study period of one year, expiratory nasal peak flow and sense of smell were monitored. In general, the course in the two groups was alike, with a tendency favouring the medically treated group. In another study the clinical efficacy of this medical regimen was further documented experimentally. By acoustic rhinometry the square area of the nasal passages was measured before and a few days after the injection of the steroid deposit. Increased volume was found, corresponding to the instant clinical improvement. It is concluded that primary treatment of nasal polyps should be medical. Surgery is only recommended in cases, resistant to medical therapy.
Lildholdt
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Dept. of O.R.L., Vejle Hospital, Denmark.
D000281:Administration, Intranasal; D000403:Airway Resistance / Q000187:drug effects; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D005500:Follow-Up Studies; D005938:Glucocorticoids; D006801:Humans; D007273:Injections, Intramuscular; D009298:Nasal Polyps / Q000188:drug therapy / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D011446:Prospective Studies; D011897:Random Allocation
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; C028994:betamethasone sodium phosphate; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone