The lipid environment of the nicotinic acetylcholine receptor in native and reconstituted membranes.
Detailed knowledge of the membrane framework surrounding the nicotinic acetylcholine receptor (AChR) is key to an understanding of its structure, dynamics, and function. Recent theoretical models discuss the structural relationship between the AChR and the lipid bilayer. Independent experimental data on the composition, metabolism, and dynamics of the AChR lipid environment are analyzed in the first part of the review. The composition of the lipids in which the transmembrane AChR chains are inserted bears considerable resemblance among species, perhaps providing this evolutionarily conserved protein with an adequate milieu for its optimal functioning. The effects of lipids on the latter are discussed in the second part of the review. The third part focuses on the information gained on the dynamics of AChR and lipids in the membrane, a section that also covers the physical properties and interactions between the protein, its immediate annulus, and the bulk lipid bilayer.
Barrantes
F J
FJ
Institute of Biochemistry, CONICET, Universidad Nac. del Sur, Bahia Blanca, Argentina.
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D002462:Cell Membrane / Q000032:analysis / Q000502:physiology*; D015640:Ion Channel Gating; D008051:Lipid Bilayers / Q000032:analysis; D008954:Models, Biological; D011978:Receptors, Nicotinic / Q000502:physiology*
D008051:Lipid Bilayers; D011978:Receptors, Nicotinic; D000109:Acetylcholine