title: [State of insulin receptors and carbohydrate metabolism in children with diabetes mellitus].
abstract: Diabetes mellitus children demonstrate the lowering of insulin binding by lymphocytes on appearance of the signs of insulin overdosage. After standard breakfast preceded by insulin injection such patients show a lower blood content of ATP as compared to children without metabolic signs of insulin overdosage, which may be of importance in the pathogenesis of insulin resistance development. Patients with type I diabetes mellitus and hyperlactatemia manifested the lowering of glucose assimilation by lymphocytes whatever the presence of the signs of insulin overdosage, pointing to insulin resistance.
authors.forename: L L
authors.initials: LL
authors.lastname: Vakhrusheva
authors.forename: N P
authors.initials: NP
authors.lastname: Mikaelian
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Kniazev
authors.forename: N A
authors.initials: NA
authors.lastname: Sergeeva
mesh_terms: D000255:Adenosine Triphosphate / Q000097:blood; D000293:Adolescent; D050260:Carbohydrate Metabolism; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000378:metabolism*; D007333:Insulin Resistance; D007773:Lactates / Q000097:blood; D008214:Lymphocytes / Q000378:metabolism; D011972:Receptor, Insulin / Q000032:analysis*
chemical_list: D000255:Adenosine Triphosphate; D006442:Glycated Hemoglobin; D007328:Insulin; D007773:Lactates; D011972:Receptor, Insulin
vernacular_title: Sostoianie insulinovykh retseptorov i uglevodnogo obmena u deteĭ, bol'nykh sakharnym diabetom.