title: Stretch of vascular smooth muscle activates tone and 45Ca2+ influx.
abstract: A number of blood vessels develop and maintain an active tone when stretched in vitro. The magnitude of this tone is related to the concentration of extracellular Ca2+. We propose that stretch-induced tone is primarily associated with 45Ca2+ influx, and is minimally affected by the release of intracellular stores of Ca2+. The characteristics of stretch-induced 45Ca2+ influx and tone are distinct from those due to depolarization with K+ and are not dependent on the endothelium. Stretch-induced tone was not altered by increases in the extracellular concentration of K+ nor by removal of the endothelium. Activators of protein kinase C increased, while inhibitors of the enzyme attenuated, stretch-induced tone. We propose that in some blood vessels, stretch per se allows the Ca2+ influx that leads to tone. Stretch-induced tone may be regulated by protein kinase C.
authors.affiliation: University of Vermont, Department of Pharmacology, Burlington 05405.
authors.forename: I
authors.initials: I
authors.lastname: Laher
authors.forename: J A
authors.initials: JA
authors.lastname: Bevan
mesh_terms: D000818:Animals; D001488:Basilar Artery; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D009119:Muscle Contraction; D009129:Muscle Tonus / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D011188:Potassium / Q000494:pharmacology; D011493:Protein Kinase C / Q000502:physiology
chemical_list: D002132:Calcium Radioisotopes; D011493:Protein Kinase C; D011188:Potassium; D002118:Calcium