title: Monthly injectable steroid contraceptives and cervical carcinoma.
abstract: The World Health Organization Collaborative Study of Neoplasia and Steroid Contraceptives is a large multinational hospital-based case-control study of steroid contraceptives and gynecologic, hepatobiliary, and mammary neoplasms. Monthly injectable steroid contraceptives which contained the long-acting progestogen dihydroxyprogesterone acetofenide plus a shorter-acting estrogen (usually estradiol enanthate) were used by women in two of the countries (Chile and Mexico) from which data were collected. In preliminary analyses of data from Chile (1979-1983), a strong association was observed between use of these products and invasive cervical cancer. Therefore, three additional data sets from these two countries were analyzed in further detail for this report. Analyses of additional data from Chile on invasive cervical cancer (1983-1985) and cervical carcinoma in situ (1979-1986) and of data on invasive cervical cancer from Mexico (1979-1986) failed to confirm the initially observed association. The original finding was probably due to chance, but a causal interpretation cannot be confidently ruled out, and additional studies are warranted.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
authors.forename: D B
authors.initials: DB
authors.lastname: Thomas
authors.forename: R
authors.initials: R
authors.lastname: Molina
authors.forename: H
authors.initials: H
authors.lastname: Rodriguez Cuevas
authors.forename: R M
authors.initials: RM
authors.lastname: Ray
authors.forename: G
authors.initials: G
authors.lastname: Riotton
authors.forename: A
authors.initials: A
authors.lastname: Dabancens
authors.forename: S
authors.initials: S
authors.lastname: Benavides
authors.forename: L
authors.initials: L
authors.lastname: Martinez
authors.forename: O
authors.initials: O
authors.lastname: Salas
authors.forename: J A
authors.initials: JA
authors.lastname: Pallet
mesh_terms: D000463:Algestone Acetophenide / Q000008:administration & dosage / Q000009:adverse effects; D002277:Carcinoma / Q000139:chemically induced* / Q000175:diagnosis; D002677:Chile; D002986:Clinical Trials as Topic; D003270:Contraceptive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D007267:Injections; D008800:Mexico; D015337:Multicenter Studies as Topic; D011795:Surveys and Questionnaires; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D003270:Contraceptive Agents; D004338:Drug Combinations; D004967:Estrogens; D000463:Algestone Acetophenide