Effect of neonatal spleen and thymus implants on H-Y incompatible skin grafts.
The transplantation reactivity of adult splenectomized C57BL females to H-Y incompatible skin grafts was significantly reduced by the implantation of spleen and thymus from foetal or 0-1-day-old syngeneic female donors. The thymus implant served as a possible source of natural suppressor cell precursors and the spleen implant as a microenvironment for their maturation.
Skowron-Cendrzak
A
A
Kubera
M
M
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology / Q000601:surgery*; D005260:Female; D006085:Graft Survival; D006182:H-Y Antigen / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012867:Skin / Q000276:immunology; D016038:Skin Transplantation; D013154:Spleen / Q000276:immunology / Q000637:transplantation*; D013156:Splenectomy; D013950:Thymus Gland / Q000276:immunology / Q000637:transplantation*; D013997:Time Factors
D006182:H-Y Antigen