title: Dosimetric considerations of stereotactic brain implants.
abstract: Dose distributions of stereotactic brain implants performed by four institutions were analyzed. In these implants 192Ir or 125I sources were used. The analyses involved an evaluation of the isodose distributions in two orthogonal planes, the dose gradient outside, and the dose homogeneity within the target volume. Quantitative evaluation of the dose homogeneity was performed using three volumetric irradiation indices. The dose homogeneity was observed to improve as the number of catheters increased. However, the number of catheters used is influenced by neurosurgical considerations. Thus, it is necessary to make a compromise between dose homogeneity and the maximum number of catheters to be used. The dose gradient, a centimeter outside the target volume, was found to depend on the geometry of the implant and at distances beyond, it was found to depend on the type of radioisotopes used.
authors.affiliation: Department of Radiation Oncology and Nuclear Medicine, Thomas Jefferson University Hospital, Philadelphia, PA 19107.
authors.forename: C B
authors.initials: CB
authors.lastname: Saw
authors.forename: N
authors.initials: N
authors.lastname: Suntharalingam
authors.forename: K M
authors.initials: KM
authors.lastname: Ayyangar
authors.forename: L
authors.initials: L
authors.lastname: Tupchong
mesh_terms: D001918:Brachytherapy; D001932:Brain Neoplasms / Q000532:radiotherapy*; D006801:Humans; D007205:Indium Radioisotopes / Q000627:therapeutic use; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D013238:Stereotaxic Techniques
chemical_list: D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes