[Use of prazosin and capoten in the treatment of heart failure in patients with ischemic heart disease].
Eighty eight patients with ischemic heart disease were studied. There was a significant increase in pulmonary blood flow time (Tp), pulmonary blood volume (BVp). mean pulmonary pressure (MPP), and total pulmonary resistance (TPR). as regarded as initial signs of heart failure, in group 1 that comprised 35 patients out of 65 after a graded isometric loading test. After prazosin therapy, these patients showed a significant decrease in blood pressure, only moderate reduction in MPP and TPR, and a rise of the cardiac index (CI). There was a significant decrease in Tp, BVp, MPP, TPR during the loading test following the therapy. From group 2, 23 patients were treated with capoten. The monotherapy was beneficial in 9 patients, capoten was discontinued in 1 case; 13 patients received a combined therapy with glycosides and saluretics. In all the cases, a positive clinical and hemodynamic effect (lower blood pressure, total peripheral resistance, BVp, higher CI with virtually unchanged heart rate) was achieved.
Burduli
F U
FU
Khadzhidis
P K
PK
Vatsadze
T G
TG
Tabidze
G A
GA
D000328:Adult; D002216:Captopril / Q000627:therapeutic use*; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000150:complications*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D011224:Prazosin / Q000627:therapeutic use*; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D002216:Captopril; D011224:Prazosin
Primenenie prazozinai kapotena dlia lecheniia serdechnoĭ nedostatochnosti u bo'lnykh ishemicheskoĭ bolez'niu serdtsa.