Minaprine: an anticholinergic-free antidepressant? Results of a controlled trial of mianserin.
Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of anticholinergic effects, cardiotoxicity, drowsiness, and weight gain. Minaprine (100 mg t.d.s. and 100 mg b.d.) was compared with mianserin (20 mg t.d.s.) in 117 depressed patients, and all three regimes produced significant reductions in scores on the HRSD at the end of six weeks' treatment. There were no anticholinergic effects, but there was a significantly greater incidence of drowsiness with mianserin than with minaprine.
Wheatley
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Psychopharmacology Research Group, Surrey.
D000928:Antidepressive Agents / Q000008:administration & dosage*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000008:administration & dosage*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011724:Pyridazines / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic
D000928:Antidepressive Agents; D011724:Pyridazines; C006149:minaprine; D008803:Mianserin