Changes in prostaglandin renal synthesis in cardiovascular disease.
We investigated the factors able to stimulate (hormones, drugs, fluid volume changes and prostaglandin precursors) or inhibit (NSAIDs) renal prostaglandin synthesis. We then assessed the effects of NSAIDs on: A) the efficacy of certain drugs (furosemide, ACE-inhibitors), whose action is mediated by a stimulation of prostaglandin synthesis; B) the physiopathology of cardiovascular diseases such as myocardial infarction and heart failure, in which renal and circulatory output is reduced; C) arterial hypertension.
Fontana
F
F
Guardigli
G
G
Ruffini
M
M
Chiarella
M
M
Spagnolo
N
N
de Collibus
C
C
Bastagli
L
L
Bernardi
P
P
D002318:Cardiovascular Diseases / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis*
D011453:Prostaglandins