title: Is diazepam an antidepressant?
abstract: In double-blind sequential study, diazepam was compared with the proven antidepressant moclobemide, in patients with atypical depression. Both agents significantly improved depression ratings over eight weeks of treatment. Diazepam was a significantly better antidepressant than moclobemide at four week, although not at eight weeks. All patients ceased diazepam within one year and none reported withdrawal reactions. These data suggest the need to reconsider that benzodiazepines may be antidepressants and to study their possible antidepressant actions.
authors.affiliation: Department of Psychiatry, Univerisity of Melbourne.
authors.forename: J W
authors.initials: JW
authors.lastname: Tiller
authors.forename: I
authors.initials: I
authors.lastname: Schweitzer
authors.forename: K P
authors.initials: KP
authors.lastname: Maguire
authors.forename: B
authors.initials: B
authors.lastname: Davis
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000523:psychology; D001143:Arousal / Q000187:drug effects; D001549:Benzamides / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D003975:Diazepam / Q000627:therapeutic use*; D006801:Humans; D020912:Moclobemide; D011569:Psychiatric Status Rating Scales; D016032:Randomized Controlled Trials as Topic
chemical_list: D000928:Antidepressive Agents; D001549:Benzamides; D020912:Moclobemide; D003975:Diazepam