title: Proarrhythmia: a paradoxic response to antiarrhythmic agents.
abstract: Antiarrhythmic drugs may effectively terminate and prevent symptomatic tachycardias, but they may also provoke life-threatening rhythm disturbances. The electrophysiologic mechanisms responsible for proarrhythmia can be extrapolated from the existing models of reentry and abnormal automaticity. Although all antiarrhythmic drugs may cause proarrhythmia with seemingly similar frequency, the profile of the disturbance with each class of agents appears somewhat distinct. All agents may cause an increased frequency of premature beats or new or worsened ventricular tachycardia, but the classic form of proarrhythmia due to type la agents is torsades de pointes. Recent information has provided clues to the underlying mechanism of drug-induced torsades de pointes and has provided a clinical picture of patients with this adverse effect. Types lb and lc agents only rarely precipitate torsades de pointes. The latter, however, may cause a rapid, sustained, monomorphic ventricular tachycardia in certain high-risk patients that can be resistant to resuscitation efforts. Amiodarone may cause a broad variety of arrhythmias that are complicated by their extended duration and difficulty in distinguishing proarrhythmia from simple inefficacy. Proarrhythmia is a relatively common, paradoxic side effect that necessitates the clinician to make careful risk-benefit decisions in choosing antiarrhythmic drug therapy.
authors.affiliation: Department of Pharmacy Practice, University of Illinois, Chicago 60612.
authors.forename: P L
authors.initials: PL
authors.lastname: McCollam
authors.forename: R B
authors.initials: RB
authors.lastname: Parker
authors.forename: K J
authors.initials: KJ
authors.lastname: Beckman
authors.forename: R J
authors.initials: RJ
authors.lastname: Hariman
authors.forename: J L
authors.initials: JL
authors.lastname: Bauman
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans
chemical_list: D000889:Anti-Arrhythmia Agents