title: Advanced breast cancer. A randomised trial of epidoxorubicin at two different dosages and two administration systems.
abstract: Sixty-two women with advanced breast cancer have been entered into a randomised trial comparing bolus injection with 24-h infusion of epirubicin given as a dose of either 20 mg or 40 mg weekly, of which 57 patients are eligible for analysis. Bolus injection proved significantly more successful than prolonged infusion in response rate, time to first event and survival. No significant differences appeared between the two doses using these measures, however 40 mg weekly was significantly more toxic than 20 mg weekly. Epirubicin given as a weekly 20 mg bolus injection appears both effective and relatively free from toxicity.
authors.affiliation: Department of Surgery, King's College Hospital, London, England.
authors.forename: S R
authors.initials: SR
authors.lastname: Ebbs
authors.forename: J A
authors.initials: JA
authors.lastname: Saunders
authors.forename: H
authors.initials: H
authors.lastname: Graham
authors.forename: R P
authors.initials: RP
authors.lastname: A'Hern
authors.forename: T
authors.initials: T
authors.lastname: Bates
authors.forename: M
authors.initials: M
authors.lastname: Baum
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality; D004334:Drug Administration Schedule; D015251:Epirubicin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic
chemical_list: D015251:Epirubicin