[Immunization with partner's lymphocytes of women subject to recurrent early spontaneous abortions].
In the early 1980s a new, although still empirical therapy was proposed for women undergoing recurrent spontaneous abortions of unknown origin, where an immunologic cause is suspected. The treatment consists in immunization of the women with human lymphocytes. We report here on our own first experience with this modality and discuss the results in light of the different immunologic tests which were performed before and after immunization with paternal lymphocytes. 11/13 treated women belong to the group with abortions of alloimmune origin, 6/11 patients were delivered of a normal baby in the 40th week of gestation (median), one patient is pregnant in the 36th week of gestation, 2 had abortions again and two women are not yet pregnant. Further investigations suggest that 2/13 women had abortions of autoimmune origin; one of these women had a normal baby in the 33rd week of gestation and the other is pregnant in the 18th week.
Soulier-Lauper
M
M
Hämatologisches Zentrallabor, Universität, Inselspital Bern.
Pichler
W
W
Jeannet
M
M
von Felten
A
A
Brun del Re
G
G
D000026:Abortion, Habitual / Q000276:immunology / Q000517:prevention & control*; D000328:Adult; D001324:Autoantigens / Q000276:immunology; D005220:Fathers; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007114:Immunization / Q000379:methods*; D007519:Isoantigens; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D011257:Pregnancy Proteins / Q000276:immunology
D001324:Autoantigens; D006680:HLA Antigens; D007519:Isoantigens; D011257:Pregnancy Proteins; C055067:trophoblast-lymphocyte cross-reactive antigens
Immunisation de 13 femmes sujettes à des avortements spontanés précoces à répétition par des lymphocytes du partenaire.