Minor burns: treatment using a new drug delivery system with silver sulfadiazine.
We investigated a new product for treatment of burn wounds in outpatients. The product is a drug delivery system composed of polyethylene glycol 400, poly-2-hydroxyethyl methacrylate, and dimethyl sulfoxide into which silver sulfadiazine is incorporated for sustained release. It is applied to the wound and changed every four to five days until the wound has epithelialized. Of the 20 patients we treated by this method, none had wound infections. Most patients had partial-thickness injuries that epithelialized without difficulty. One patient with full-thickness injuries required subsequent excision and grafting. Application of the product over joint surfaces facilitated range of motion. The product was easy to apply, it diminished pain, and it produced no abnormal effects except for an occasional bad odor.
Cruse
C W
CW
Department of Surgery, College of Medicine, University of South Florida, Tampa.
Daniels
S
S
D000179:Acrylates / Q000008:administration & dosage*; D000268:Adhesiveness; D002056:Burns / Q000188:drug therapy*; D002648:Child; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage* / Q000627:therapeutic use; D004338:Drug Combinations / Q000008:administration & dosage / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008689:Methacrylates / Q000008:administration & dosage* / Q000627:therapeutic use; D009779:Occlusive Dressings; D010342:Patient Acceptance of Health Care; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000627:therapeutic use; D012837:Silver Sulfadiazine / Q000008:administration & dosage* / Q000627:therapeutic use; D013411:Sulfadiazine / Q000008:administration & dosage*
D000179:Acrylates; D003692:Delayed-Action Preparations; C059435:Dimac-SSD; D004338:Drug Combinations; D008689:Methacrylates; D013411:Sulfadiazine; D011092:Polyethylene Glycols; D012837:Silver Sulfadiazine; D004121:Dimethyl Sulfoxide