title: Sutureless nerve repair at the fascicular level using a nerve coupler.
abstract: Peripheral nerves are transected in many traumatic injuries of the extremities. Satisfactory functional regeneration of such nerves often fails to occur after repair with sutures. Possible reasons for these failures include poor alignment of nerves or fascicles, intrusion of scar tissue into the nerve junction, and outgrowth of nerve tissue from the repair site. This animal study describes an experimental method of sutureless, monofascicular peripheral nerve repair using a resorbable nerve coupler in the rat model. The first version of this coupler shows approximately equal performance to suture repair. Histology and electrophysiology assessments after regeneration showed that the polyglycolic acid (PGA) tube repairs were functionally equal to monofascicular suture junctions as well as being quicker and simpler to perform. Modified coupler designs based on this and other work show greater promise. Collateral studies are using similar versions of the nerve coupler as a vehicle for the insertion of chemical and neuro-electronic factors that may enhance nerve regeneration.
authors.affiliation: Stanford University School of Medicine, Div. of Plastic and Reconstructive Surgery, CA 94305.
authors.forename: D M
authors.initials: DM
authors.lastname: Marshall
authors.forename: M
authors.initials: M
authors.lastname: Grosser
authors.forename: M C
authors.initials: MC
authors.lastname: Stephanides
authors.forename: R D
authors.initials: RD
authors.lastname: Keeley
authors.forename: J M
authors.initials: JM
authors.lastname: Rosen
mesh_terms: D000818:Animals; D008297:Male; D008722:Methods; D009412:Nerve Fibers / Q000601:surgery*; D009416:Nerve Regeneration; D051381:Rats; D011919:Rats, Inbred Strains