[Glucose utilization in adipose tissue of rats in chronic somatotropin deficiency].
Injections of monosodium glutamate to neonate rats induce chronic growth hormone deficiency by hypothalamic lesions in the regions of the nucleus arcuatus and the eminentia mediana. The glutamate treated rats develop massive obesity. By this type of obesity hyperinsulinemia in the dynamic phase is not evident. The adipose tissue of the GOR (glutamate obese rat) is characterized by hypertrophic adipocytes and diminished number of adipocytes. In the GOR glucose oxidation and glucose lipid conversion are increased, but insulin sensitivity of glucose metabolism is diminished. The enhanced glucose utilization in adipose tissue of the GOR is discussed as being the consequence of the chronic growth hormone deficiency.
Wilsdorf
A
A
Institut für Pathologische Biochemie, Karl Marx Universität Leipzig.
Remke
H
H
Müller
F
F
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D005947:Glucose / Q000378:metabolism*; D005971:Glutamates / Q000633:toxicity*; D013006:Growth Hormone / Q000172:deficiency*; D007031:Hypothalamus / Q000187:drug effects / Q000473:pathology*; D007328:Insulin / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D009765:Obesity / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012970:Sodium Glutamate / Q000633:toxicity*
D005971:Glutamates; D007328:Insulin; D013006:Growth Hormone; D005947:Glucose; D012970:Sodium Glutamate
Glukoseverwertung im Fettgewebe von Ratten bei chronischem Somatotropinmangel.