Engraftment and transfusion requirements after allogeneic marrow transplantation for patients with acute non-lymphocytic leukemia in first complete remission.
This retrospective study analysed factors affecting engraftment and transfusion requirements of platelets and red blood cells in 303 patients transplanted for acute non-lymphocytic leukemia in first remission from HLA-identical or one-antigen mismatched donors. Multivariant analysis showed that the most important factors affecting the speed of engraftment were drugs used for graft-versus-host disease (GVHD) prophylaxis, the development of acute GVHD and HLA matching. Factors affecting only granulocyte recovery included patient age and sex. The radiation regimen used for preparing patients affected the time to platelet independence. Patients transplanted in laminar airflow rooms took longer to achieve red cell independence and required more units of red cells and platelets than patients transplanted in regular rooms. In addition, ABO incompatibility affected red cell transfusion requirements while GVHD prophylaxis and acute GVHD influenced both red blood cells and platelet support.
Bensinger
W
W
Fred Hutchinson Cancer Research Center, Puget Sound Blood Center, Seattle, WA 98104.
Petersen
F B
FB
Banaji
M
M
Buckner
C D
CD
Clift
R
R
Slichter
S J
SJ
Storb
R
R
Thomas
E D
ED
D000328:Adult; D001803:Blood Transfusion; D016026:Bone Marrow Transplantation; D005260:Female; D006086:Graft vs Host Disease / Q000473:pathology; D006648:Histocompatibility; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012074:Remission Induction; D012189:Retrospective Studies; D014184:Transplantation, Homologous