Interleukin 4 induces selective production of interleukin 6 from normal human B lymphocytes.
In this paper we have shown that extensively purified human B lymphocytes respond to IL-4 treatment with a marked production of IL-6. Addition of anti-mu potentiated the effect of IL-4 on IL-6 production. Other cytokines tested like TNF-alpha and-beta, IFN-gamma, IL-1, IL-2, and IL-5 did not induce IL-6 secretion when given to resting B cells. Although B cells generally also produced TNF-alpha and TNF-beta upon stimulation, IL-4 did not induce TNF secretion and seemingly had a specific effect on IL-6 production.
Smeland
E B
EB
Department of Pathology, Institute for Cancer Research, Montebello, Oslo, Norway.
Blomhoff
H K
HK
Funderud
S
S
Shalaby
M R
MR
Espevik
T
T
D001402:B-Lymphocytes / Q000502:physiology*; D001685:Biological Factors / Q000494:pharmacology; D016207:Cytokines; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D015847:Interleukin-4 / Q000494:pharmacology*; D015850:Interleukin-6 / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D010703:Phorbol Esters / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D001685:Biological Factors; D016207:Cytokines; D015850:Interleukin-6; D010703:Phorbol Esters; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4