Effects of testosterone on blood leukocytes in plasmodium berghei-infected mice.
Gonadectomized male mice aged 5 weeks were given 5 mg testosterone propionate daily for 14 days. The treatment significantly decreased the number of blood leukocytes. The number of all individual types of leukocytes except basophils in vehicle-treated gonadectomized mice was increased. Testosterone-treated mice consistently had a lower number of leukocytes after being infected with Plasmodium berghei than did vehicle-treated mice. The results suggest that testosterone suppresses the production of leukocytes and that testosterone-treated mice become more susceptible to parasite infection.
Kamis
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AB
Jabatan Zoology, Faculty of Life Sciences, University Kebangsaan Malaysia, Bangi.
Ibrahim
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JB
D000818:Animals; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology*; D008288:Malaria / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009919:Orchiectomy; D010962:Plasmodium berghei; D013739:Testosterone / Q000502:physiology* / Q000627:therapeutic use
D013739:Testosterone