Mutagenicity of ptaquiloside, the carcinogen in bracken, and its related illudane-type sesquiterpenes. I. Mutagenicity in Salmonella typhimurium.
Ptaquiloside, a potent carcinogen of an illudane-type sesquiterpene glycoside isolated from Pteridium aquilinum, and its related compounds, hypolosides having the same nucleus isolated from the Pteridaceae, exhibited marked mutagenicity in the modified Ames test with Salmonella typhimurium TA98 and TA100 using a preincubation at pH 8.5. Illudins M and S, sesquiterpenes of the same illudane type from basidiomycetes, also exhibited mutagenicity. The structural requirements for mutagenicity are discussed.
Nagao
T
T
Meiji College of Pharmacy, Tokyo, Japan.
Saito
K
K
Hirayama
E
E
Uchikoshi
K
K
Koyama
K
K
Natori
S
S
Morisaki
N
N
Iwasaki
S
S
Matsushima
T
T
D066298:In Vitro Techniques; D007189:Indans; D009152:Mutagenicity Tests; D009153:Mutagens; D000081223:Polycyclic Sesquiterpenes; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012717:Sesquiterpenes / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000633:toxicity*
D007189:Indans; D009153:Mutagens; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D013729:Terpenes; C008105:illudin S; C043680:ptaquiloside