title: [Treatment of unstable diabetes mellitus in children and adolescents using insulin administered by a semi-automated syringe, NovoPen].
abstract: An insulin device, NovoPen, incorporating human actrapid insulins was used in a group of 6 poor--controlled diabetic adolescents, aged 15 years (mean 8-18.7) with duration of diabetes 8.2 +/- 4.8 years (mean +/- S.D). The study was carried out in insulin-dependent diabetic young-people, to test the efficacy and acceptance of an intensified insulin therapy (an injection of short-acting insulin before each of the three meals using NovoPen plus an evening injection of human ultratard insulin from a conventional syringe) in the hope of achieving the improved control. All patients completed a 6-months NovoPen-therapy and preferred to continue with the multiple injection regimen in the long term. Metabolic control was improved, the values of haemoglobin A1c decreased from 16.8% to 13.4% (statistically significant) during the study. The use of the NovoPen injection device proved to be a safe and acceptable method of therapy; it offered the patients a marked freedom and liberalization of everyday life.
authors.forename: S
authors.initials: S
authors.lastname: Necić
authors.forename: M
authors.initials: M
authors.lastname: Nikezić
authors.forename: S
authors.initials: S
authors.lastname: Sajić
authors.forename: S
authors.initials: S
authors.lastname: Radmanović
mesh_terms: D000293:Adolescent; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous / Q000295:instrumentation*; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male
chemical_list: D007328:Insulin
vernacular_title: Lecenje nestabilonog dijabetes melitusa kod dece i adolescenata insulinom uz pomoć poluautomatske brizgalice-NovoPen.