title: [Shock. Antioxidant immunologico-therapeutic replacement].
abstract: Shock is a specific reaction to a non specific severe injury. The organic reaction is a biphasic (excitation/depression) threefold response: haemodynamic, hemostatic and immunologic. The physiopathology is related with changes produced by injury on macrophages, neutrophils, platelets and endothelial cells. The release of enzymes and certain vasoactive compounds enhance activation of neutrophils, which produce great amounts of free oxygen radicals. Therapy must be basically substitutive, including immunologic substitution. Therapeutic trends are based on the use of substances which can avoid the overproduction or nocive effects of free oxygen radicals.
authors.forename: J
authors.initials: J
authors.lastname: Cochs
authors.forename: E
authors.initials: E
authors.lastname: Buendia
authors.forename: A
authors.initials: A
authors.lastname: Sabaté
authors.forename: M
authors.initials: M
authors.lastname: Mestre
authors.forename: F
authors.initials: F
authors.lastname: Martínez-Brotons
authors.forename: J R
authors.initials: JR
authors.lastname: Oncins
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy; D008214:Lymphocytes / Q000145:classification / Q000276:immunology; D012769:Shock / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D012772:Shock, Septic / Q000276:immunology / Q000503:physiopathology / Q000628:therapy
chemical_list: D000975:Antioxidants
vernacular_title: Consideraciones acerca del shock. Substitución inmunológica-terapéutica antioxidante.