Determination of saliva: total plasma chloroquine levels relationship by high performance liquid chromatography.
The use of saliva chloroquine concentrations measurement as a noninvasive technique in the evaluation of the pharmacokinetics of the drug was investigated. Chloroquine concentrations in saliva and plasma were measured in eight healthy volunteers after a single oral dose of two tablets of chloroquine sulfate. The saliva: total plasma concentrations (S/P) ratio was found to be approximately constant in the absorption (0.4 +/- 0.07), distribution (0.47 +/- 0.08), and elimination (0.46 +/- 0.05) phases. Thus, saliva sampling for chloroquine concentrations was found to be a useful noninvasive technique for the estimation of all the pharmacokinetic parameters of the drug and hence, for chloroquine pharmacokinetic studies.
Brown-Awala
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EA
Department of Clinical Pharmacy and Biopharmacy, School of Pharmacy, College of Medicine, University of Lagos, Nigeria.
Thomas
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WO
Essien
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EE
Ette
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EI
D000328:Adult; D002738:Chloroquine / Q000032:analysis* / Q000097:blood / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D012463:Saliva / Q000032:analysis*; D013997:Time Factors
D002738:Chloroquine