title: Effects of long-term immunization against LHRH and androgen treatment on gonadal function.
abstract: The possibility of immunological suppression of spermatogenesis while normal libido is maintained by exogenous androgen supplementation was tested in male rats. Neither short- nor long-term treatment with androgen (testosterone-17-trans-4-N-butyl-cyclohexane carboxylate) alone influenced fertility. Active immunization against LHRH administered simultaneously with exogenous androgen supplement caused infertility in 100% of the tested animals, all of which displayed normal sexual behavior. The atrophy of the testes and accessory sex organs was reversible.
authors.affiliation: Population Council, New York, NY 10021.
authors.forename: A
authors.initials: A
authors.lastname: Ladd
authors.forename: Y Y
authors.initials: YY
authors.lastname: Tsong
authors.forename: G
authors.initials: G
authors.lastname: Prabhu
authors.forename: R
authors.initials: R
authors.lastname: Thau
mesh_terms: D000818:Animals; D001284:Atrophy; D003267:Contraception; D003269:Contraception, Immunologic; D005298:Fertility / Q000187:drug effects; D005837:Genitalia, Male / Q000473:pathology; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D007114:Immunization; D007989:Libido / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013091:Spermatogenesis; D013737:Testis / Q000187:drug effects / Q000473:pathology; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: C050320:testosterone 4-n-butylcyclohexylcarboxylic acid; D007987:Gonadotropin-Releasing Hormone; C060880:LHRH, Gly(10)-; D013739:Testosterone