[Several recent advances in the significance and properties of interleukins].
The interleukins play an important role as intensifying molecules in the activation of the immune system in infections and inflammation processes. Antigens are worked up by macrophages and B-lymphocytes, whereby partly develop particularly intensively antigen-effective compounds. The uptake of antigens in macrophages evokes the formation of interleukin 1 which has multivarious effects. The macrophages and the B-lymphocytes present the antigens worked up after uptake into the cell membrane to certain forms of T-lymphocytes which thus are stimulated to the formation of the interleukins 2 to 6. The interleukins 2 and 4 promote the increase of certain forms of T-lymphocytes and the formation of cytotoxically acting T-lymphocytes. The interleukin 3 is of importance for the increase of stem cells of the bone-marrow and for their differentiation. The interleukins 4, 5, and 6 promote the increase of certain B-lymphocytes. In the liver the interleukins 1 and 6 stimulate the formation of numerous proteins which have influence on inflammation processes.
Kolb
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E
Wissenschaftsbereich Tierbiochemie, Karl-Marx-Universität Leipzig.
D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007239:Infections / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D007378:Interleukins / Q000502:physiology*; D011971:Receptors, Immunologic / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology
D007378:Interleukins; D011971:Receptors, Immunologic
Einige neuere Erkenntnisse zur Bedeutung und zu den Eigenschaften der Interleukine.