title: [Respiratory insufficiency and its treatment in threatened multiple organ failure].
abstract: Multiple organ failure (MOF) is nowadays a frequent cause of death in the ICU. The pathophysiology is similar to that of ARDS: a generalized inflammatory reaction, a sepsis syndrome and a permeability disorder of the GI tract play major roles. Respiratory failure can cause or aggravate MOF, and pulmonary gas exchange must be improved and stabilized rapidly. However, ventilatory support may cause pulmonary problems able to trigger or maintain MOF, for instance bronchopulmonary superinfection or barotrauma. Side effects of positive pressure ventilation on other organ function must be avoided or treated. It seems clear today that MOF is associated with a systemic oxygen extraction defect. However, the beneficial effect of an artificial increase in oxygen transport has to be confirmed in these patients.
authors.affiliation: Department of Anesthesiology University Hospital of Geneva.
authors.forename: P M
authors.initials: PM
authors.lastname: Suter
mesh_terms: D003131:Combined Modality Therapy; D003422:Critical Care / Q000379:methods*; D006801:Humans; D009102:Multiple Organ Failure / Q000628:therapy*; D011175:Positive-Pressure Respiration; D011379:Prognosis; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D012131:Respiratory Insufficiency / Q000628:therapy*
vernacular_title: Respiratorische Insuffizienz und ihre Behandlung beim drohenden Multiorganversagen.