Streptomycetes producing daunomycin and related compounds: do we know enough about them after 25 years?
The growing need of highly potent anticancer agents has stimulated the investigation of streptomycetes producing daunomycin-type anthracyclines. This review compares the features of production strains and their mutants and emphasizes the necessity of application of biochemical and biophysical analytical methods for better understanding these microorganisms and, above all, their further improving and practical usage.
Huk
J
J
Research Institute of Antibiotics and Biotransformation, Prague, Czechoslovakia.
Blumauerova
M
M
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000266:history; D001711:Biotransformation; D003630:Daunorubicin / Q000096:biosynthesis* / Q000266:history; D049673:History, 20th Century; D009154:Mutation; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D003630:Daunorubicin