title: A double-blind study of topical 1 alpha,25-dihydroxyvitamin D3 in psoriasis.
abstract: Several open studies with active forms of vitamin D3 have been reported to be effective in the treatment of psoriasis. We report a double-blind study of 1 alpha,25-dihydroxycholecalciferol in psoriasis using 0.5 microgram of active substance applied topically twice daily. In contrast to previous studies, the present investigation does not provide evidence of clinical efficacy for the drug at that dosage and with the vehicle that was used.
authors.affiliation: Department of Dermatology, University Hospital, Nijmegen, The Netherlands.
authors.forename: P C
authors.initials: PC
authors.lastname: van de Kerkhof
authors.forename: M
authors.initials: M
authors.lastname: van Bokhoven
authors.forename: M
authors.initials: M
authors.lastname: Zultak
authors.forename: B M
authors.initials: BM
authors.lastname: Czarnetzki
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D002117:Calcitriol / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000473:pathology
chemical_list: D002117:Calcitriol