Glucose metabolism and insulin secretion in infants with symptomatic ventricular septal defect.
Nineteen infants with symptomatic ventricular septal defect (VSD) were examined on, altogether, 26 occasions, when each was given an intravenous glucose tolerance test (IVGTT); concentrations of insulin- and C-peptide in plasma were determined. Comparisons were made with 14 healthy infants of the same age. The VSD infants were growth retarded with lower weight/age and length/age ratios. Glucose tolerance as indicated by glucose fasting levels and response to intravenous glucose tolerance test, including glucose disappearance rate, did not differ between the two groups. In response to the glucose load, insulin in plasma was significantly less in VSD infants. In response to the IVGTT, insulin secretion rate calculated from C-peptide levels in plasma was significantly elevated in the VSD group. We conclude that compared to healthy infants, those with symptomatic VSD have normal glucose tolerance, increased secretion rate of insulin, but decreased levels of circulating insulin in response to an intravenous glucose load. We suggest this is so because binding of insulin to peripheral receptors and/or insulin extraction in the liver somehow increases.
Lundell
K H
KH
Department of Paediatrics, Central Hospital of Jönköping, Gothenburg, Sweden.
Sabel
K G
KG
Eriksson
B O
BO
Mellgren
G
G
D001786:Blood Glucose / Q000032:analysis*; D002096:C-Peptide / Q000097:blood; D005947:Glucose / Q000008:administration & dosage; D005951:Glucose Tolerance Test; D006345:Heart Septal Defects, Ventricular / Q000097:blood* / Q000601:surgery; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007275:Injections, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D005947:Glucose