title: [Mutations and cancer].
abstract: The relationships between mutations, in a general sense, and cancer are reviewed with a special emphasis on the description of hereditary tumors. These rare diseases provide good biological models to better understand cancer initiation at the molecular level. Tumors transmitted with a recessive mode are usually linked with DNA repair deficiencies. Tumors transmitted with a dominant mode are usually linked with deletions in anti-oncogene sequences.
authors.forename: A
authors.initials: A
authors.lastname: Sarasin
mesh_terms: D000818:Animals; D004260:DNA Repair; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*
vernacular_title: Mutations et cancer.