title: Immunoradiometric assays of total renin and gonadotropins in serum during the menstrual cycle.
abstract: The contribution of the ovary to the circulating total renin pool is linked to its secretory activity in relation with its reproductive function. In a longitudinal study of 13 normal women, total renin levels measured in serum by an immunoradiometric assay were lower in the midfollicular phase (180 +/- 59 pg/ml) than in the midluteal phase (291 +/- 100 pg/ml). Peak levels were encountered 1 day after the luteinizing hormone (LH) surge (375 +/- 97 pg/ml). Rapid circhoral fluctuations were observed in all periods of the cycle, unrelated to the LH pulses. In case of ovarian function inhibition (induced by gonadotropin-releasing hormone agonists), total renin levels were lower than in the midfollicular phase (126 +/- 56 pg/ml). Low levels also were encountered in the prepubertal period (153 +/- 89 pg/ml). Very high levels (17,600 +/- 11,400 pg/ml) were found in follicular fluids from stimulated cycles. These results show that circulating total renin levels follow a complex pattern in which LH, but possibly also follicle-stimulating hormone and gonadal steroid hormones (estradiol and progesterone), may play a role.
authors.affiliation: Physiology of Human Reproduction Research Unit, University of Louvain, School of Medicine, Brussels, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: De Hertogh
authors.forename: L
authors.initials: L
authors.lastname: Vankrieken
authors.forename: M
authors.initials: M
authors.lastname: de Gasparo
authors.forename: K
authors.initials: K
authors.lastname: Thomas
mesh_terms: D000328:Adult; D001826:Body Fluids / Q000378:metabolism; D002648:Child; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006062:Gonadotropins / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008593:Menopause / Q000097:blood; D008597:Menstrual Cycle; D008875:Middle Aged; D006080:Ovarian Follicle / Q000378:metabolism; D010053:Ovary / Q000502:physiology; D011247:Pregnancy; D011627:Puberty / Q000097:blood; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood* / Q000378:metabolism
chemical_list: D012739:Gonadal Steroid Hormones; D006062:Gonadotropins; D007986:Luteinizing Hormone; D012083:Renin