title: The role of "negative" epidemiology data in the evaluation of risk.
abstract: The identification and quantification of risk is a complex process that depends upon a variety of different disciplines. All contribute, but none provides a complete and comprehensive perspective. In the past, emphasis has been placed upon the limitations of each individually. Toxicology, for example, is plagued by low predictive value positive; epidemiology, by qualitative measures of exposure. Focusing instead upon the contributions of each to the whole, and the contributions of all of the data--both "positive" and "nonpositive"--a better understanding of potential hazards can be achieved. Examples are provided for styrene and phenoxy herbicides.
authors.affiliation: Dow Chemical Company, Health and Environmental Sciences, Midland, Michigan 48674.
authors.forename: R R
authors.initials: RR
authors.lastname: Cook
mesh_terms: D000818:Animals; D002273:Carcinogens; D004812:Epidemiologic Methods; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology*; D009784:Occupational Diseases / Q000453:epidemiology; D012306:Risk
chemical_list: D002273:Carcinogens