Comparison of piroxicam with placebo in the management of pain after total hip replacement.
A randomized double-blind controlled study was undertaken to assess the analgesic efficacy of piroxicam. Twenty-four patients underwent total hip replacement under spinal anaesthetic; after operation, they received a 3-day course of either placebo (n = 12) or piroxicam (n = 12). Adequate analgesia was provided for 48 h by a patient-controlled analgesia system delivering morphine. Patients receiving piroxicam required 50% less morphine than the control group (38 mg compared with 76 mg (P less than 0.002]. This technique was tolerated well and there were no significant side effects.
Serpell
M G
MG
Department of Anaesthesia, Ninewells Hospital and Medical School, Dundee.
Thomson
M F
MF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000775:Anesthesia, Spinal; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*; D010894:Piroxicam / Q000627:therapeutic use*; D010919:Placebos; D011897:Random Allocation
D010919:Placebos; D010894:Piroxicam; D009020:Morphine