title: Effect of ketanserin on macrocirculatory and microcirculatory blood flow in patients with intermittent claudication. A prospective randomized study.
abstract: The effect of ketanserin on macrocirculatory and microcirculatory blood flow was investigated in a placebo-controlled, double-blind trial in 11 patients suffering from intermittent claudication using Doppler velocimetry and intravital skin capillary microscopy, respectively. After 1 year of treatment no significant change was observed either in the ketanserin or the placebo group. It appears that ketanserin has no significant effect on macrocirculatory blood flow and microcirculatory nutritional skin blood flow in patients with intermittent claudication.
authors.affiliation: Department of Surgery, University of Limburg, Maastricht, The Netherlands.
authors.forename: R C
authors.initials: RC
authors.lastname: Beckers
authors.forename: P J
authors.initials: PJ
authors.lastname: Jörning
authors.forename: D W
authors.initials: DW
authors.lastname: Slaaf
authors.forename: R S
authors.initials: RS
authors.lastname: Reneman
authors.forename: M J
authors.initials: MJ
authors.lastname: Jacobs
mesh_terms: D000368:Aged; D004311:Double-Blind Method; D006801:Humans; D007383:Intermittent Claudication / Q000188:drug therapy* / Q000503:physiopathology; D007650:Ketanserin / Q000494:pharmacology*; D008833:Microcirculation / Q000187:drug effects*; D008875:Middle Aged; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012039:Regional Blood Flow / Q000187:drug effects*; D012867:Skin / Q000098:blood supply
chemical_list: D007650:Ketanserin