Treatment of chronic erosive gastritis: a double-blind trial of pirenzepine and cimetidine.
In a double-blind study, 59 patients with chronic erosive gastritis received 50 mg of pirenzepine twice daily and 55 patients received 400 mg of cimetidine twice daily for six weeks. In both groups, days of pain, of heartburn, and of nausea per week were significantly reduced during treatment (P less than 0.01). After six weeks, 64% of the pirenzepine group and 62% of the cimetidine group were free of symptoms and endoscopy revealed healing of lesions in 78% and 80%, respectively. Differences between groups were not significant.
Dal Monte
P R
PR
Institute of Clinical Medicine and Gastroenterology, University of Bologna, Italy.
D'Imperio
N
N
Barillari
A
A
Vezzadini
P
P
Bensi
G
G
Imbimbo
B P
BP
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D002927:Cimetidine / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005756:Gastritis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010890:Pirenzepine / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
D010890:Pirenzepine; D002927:Cimetidine