title: Crotonaldehyde is mutagenic in Salmonella typhimurium TA100.
abstract: The mutagenicity of crotonaldehyde in Salmonella typhimurium TA100 cannot be demonstrated in the standard plate incorporation assay. However, as reported earlier by our group, this alpha, beta-unsaturated aldehyde is clearly mutagenic in the liquid assay modification of this testing procedure. Carried out because of the doubts recently expressed by Cooper et al. (Environ Mutagen 9:289-295, 1987) concerning the observed mutagenicity of crotonaldehyde in S. typhimurium TA100, this study confirms that this compound is clearly a direct (without activation by mammalian microsomes)-acting mutagen in S. typhimurium TA100 under appropriate conditions in the preincubation assay. The observed mutagenicity is increased by extended preincubation time and increased bacterial cell densities.
authors.affiliation: Institute of Toxicology, University of Würzburg, Federal Republic of Germany.
authors.forename: T
authors.initials: T
authors.lastname: Neudecker
authors.forename: E
authors.initials: E
authors.lastname: Eder
authors.forename: C
authors.initials: C
authors.lastname: Deininger
authors.forename: D
authors.initials: D
authors.lastname: Henschler
mesh_terms: D000447:Aldehydes / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics*
chemical_list: D000447:Aldehydes; D009153:Mutagens; C012796:2-butenal