Free calcium rise and mitogenesis in glial cells caused by endothelin.
The peptide endothelin causes a biphasic rise in intracellular free calcium levels in cultured Type-1 astrocytes and C6 glioma cells, suggesting that glial cells may be the physiological target of endothelin in the brain. Endothelin also causes a calcium-dependent increase [3H]thymidine incorporation in primary cultures of rat cerebellum, indicating that, among other possible roles, this peptide may mediate mitogenesis in brain.
Supattapone
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University Laboratory of Physiology, Oxford, U.K.
Simpson
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Ashley
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D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism; D001572:Benzofurans; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D002525:Cerebellar Cortex / Q000166:cytology* / Q000196:embryology; D016232:Endothelins; D004730:Endothelium, Vascular; D005456:Fluorescent Dyes; D016257:Fura-2; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014757:Viper Venoms / Q000494:pharmacology
D001572:Benzofurans; D016232:Endothelins; D005456:Fluorescent Dyes; D010455:Peptides; D014757:Viper Venoms; C057354:sarafotoxins s6; D002118:Calcium; D016257:Fura-2