Lack of correlation between translocation and biological effects mediated by protein kinase C: an appraisal.
Protein kinase C is involved in the mechanism of action of hormones, growth factors, mitogens and tumour promoters. The correlation between the extent of the biological effects mediated by protein kinase C and its fractional activation shows cell type specific patterns of behaviour. The discrepancy between enzyme activity and biological effects elicited by protein kinase C is particularly relevant to lymphoblastic cells. In B cells, the full expression of some biological responses mediated by protein kinase C may be achieved by activation of less than 5% of the enzyme activity.
Boscá
L
L
Márquez
C
C
Martínez
C
C
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats
D011493:Protein Kinase C