title: Collagen types I and III and fibronectin in healing anterior cruciate ligament after reconstruction with carbon fibre.
abstract: The presence of the connective tissue components fibronectin and collagen types I and III have been demonstrated by immunohistological methods after reconstruction of the anterior cruciate ligament of pigs with carbon fibre. The carbon fibre ligament prosthesis was covered with pediculated fascia lata. During the initial 16-week period, fibronectin was seen both in the surrounding fascial layer and between the carbon fibres of the substitute. Type III collagen was also found, especially in the fascial layer, but collagen was absent from the carbon fibre prosthesis and was seen only in the fascial layer. Results indicate that the tissue in the 'neoligament' after carbon fibre reconstruction consists mostly of granulation tissue with a high amount of fibronectin, and type III collagen from mesenchymal cells without sufficient amount of type I collagen with tensile strength to withstand subsequent mobilization and rehabilitation.
authors.affiliation: Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland.
authors.forename: S E
authors.initials: SE
authors.lastname: Mäkisalo
authors.forename: P P
authors.initials: PP
authors.lastname: Paavolainen
authors.forename: M
authors.initials: M
authors.lastname: Lehto
authors.forename: K
authors.initials: K
authors.lastname: Skutnabb
authors.forename: P
authors.initials: P
authors.lastname: Slätis
mesh_terms: D000818:Animals; D002244:Carbon; D003094:Collagen / Q000032:analysis*; D004195:Disease Models, Animal; D005353:Fibronectins / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D007150:Immunohistochemistry; D008022:Ligaments / Q000032:analysis*; D019736:Prostheses and Implants; D013552:Swine; D014945:Wound Healing
chemical_list: D005353:Fibronectins; D002244:Carbon; D003094:Collagen