Action of the ketoconazole-alkylaminoethylglycine combination on Candida albicans.
High concentrations of ketoconazole (Ktc) exhibit poor antimicrobial activity in microbicidal test. Alkylaminoethylglycine (AAEG), an amphoteric surface-active agent, employed in subinhibitory concentrations, can enhance the action of ketoconazole. The Ktc-AAEG combination causes a higher rate of potassium ion release compared to both drugs separately. The increased ketoconazole activity may be ascribed to the membrane damage indicated by increased permeability to potassium ions.
Villa
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Institute of Microbiology, Faculty of Pharmacy, University La Sapienza of Rome.
Simonetti
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Retico
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D002176:Candida albicans / Q000187:drug effects*; D002463:Cell Membrane Permeability / Q000187:drug effects; D004338:Drug Combinations; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007654:Ketoconazole / Q000008:administration & dosage / Q000494:pharmacology*
D004338:Drug Combinations; D007654:Ketoconazole; D005998:Glycine