In utero diagnosis of benign fetal macrocephaly.
Benign familial macrocephaly is an autosomal dominant disorder associated with a large absolute circumference of the head. In this disorder serial growth demonstrates a proportional rather than an excessive rate of growth. To date, we are not aware of any published case reports that confirm the diagnosis prenatally. We report a case of benign familial macrocephaly diagnosed in utero by ultrasonographic evaluation. This case report points out the necessity of combining appropriate family history and physical examination in cases of prenatally detected anomalies.
DeRosa
R
R
Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43699-0008.
Lenke
R R
RR
Kurczynski
T W
TW
Persutte
W H
WH
Nemes
J M
JM
D000328:Adult; D001927:Brain Diseases / Q000151:congenital / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D005877:Gigantism / Q000151:congenital / Q000175:diagnosis*; D006257:Head / Q000002:abnormalities*; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014463:Ultrasonography