title: Endomyocardial biopsies after heart transplantation. The presence of immunoglobulin/immune complex deposits.
abstract: A series of 221 endomyocardial biopsies (EMB), taken from 21 patients after heart transplantation, was analyzed for the presence of immunoglobulin/immune complex deposits. Data were correlated with histology (grading following Billingham) and cytoimmunologic monitoring (CIM) on blood samples (grading into negative, rejection, or infection, based on leukocyte morphology and T cell phenotype). IgM deposits and IgG/IgM complexes in blood capillaries around myocyte fibrils were found in 78 and 40 EMB, respectively. This feature was more prevalent in EMB with a histology of rejection (39 out of 52 biopsies).
authors.affiliation: Heart Transplant Team Utrecht, Groningen, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: Schuurman
authors.forename: F H
authors.initials: FH
authors.lastname: Meyling
authors.forename: P L
authors.initials: PL
authors.lastname: Wijngaard
authors.forename: A
authors.initials: A
authors.lastname: van der Meulen
authors.forename: P J
authors.initials: PJ
authors.lastname: Slootweg
authors.forename: G
authors.initials: G
authors.lastname: Jambroes
mesh_terms: D000906:Antibodies / Q000032:analysis*; D000936:Antigen-Antibody Complex / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006084:Graft Rejection; D016027:Heart Transplantation; D006801:Humans; D009206:Myocardium / Q000276:immunology*
chemical_list: D000906:Antibodies; D000936:Antigen-Antibody Complex