title: Acanthosis nigricans: a cutaneous marker of tissue resistance to insulin.
abstract: Tissue resistance to insulin is a major feature underlying the development of acanthosis nigricans in many patients. We report two unusual cases of acanthosis nigricans with contrasting forms of insulin resistance and propose an algorithm for the evaluation of patients with acanthosis nigricans. Further, we present a schematic framework that emphasizes the role of insulin and insulin growth factors in the pathogenesis of acanthosis nigricans.
authors.affiliation: Department of Dermatology, University of Texas Health Science Center, Dallas 75235.
authors.forename: M I
authors.initials: MI
authors.lastname: Rendon
authors.forename: P D
authors.initials: PD
authors.lastname: Cruz
authors.forename: R D
authors.initials: RD
authors.lastname: Sontheimer
authors.forename: P R
authors.initials: PR
authors.lastname: Bergstresser
mesh_terms: D000052:Acanthosis Nigricans / Q000150:complications / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000465:Algorithms; D015415:Biomarkers; D005260:Female; D006801:Humans; D007333:Insulin Resistance
chemical_list: D015415:Biomarkers