Antibodies to structural and nonstructural gag-coded proteins of type-D retroviruses in humans with lymphadenopathy and AIDS.
The sera of patients with lymphadenopathies (children, suffering from primary immune deficiencies) and AIDS were analysed for the presence of antibodies against D-type retroviruses by means of radioimmunoprecipitation (RIP) and Western blotting. It was established that these sera contain the antibodies derived against p27, the major structural protein of type-D retroviruses, in a considerable percentage (12/80 for lymphadenopathy (LAP) patients and 9/12 for AIDS patients). Some serum samples reacted in RIP with Pr78gag, the precursor of gag-coded proteins of these viruses. The results obtained for AIDS patients are in contrast with those reported by other research groups. Nevertheless, it seems highly probable that D-type retroviruses are truly associated with human immunodeficiencies, as has been shown for simian ones.
Morozov
V A
VA
All-Union Cancer Research Center AMS, Moscow, USSR.
Ilyinskii
P O
PO
Uckert
W A
WA
Wunderlich
W
W
Ilyin
K V
KV
D000386:AIDS-Related Complex / Q000150:complications* / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology; D000906:Antibodies / Q000276:immunology*; D015153:Blotting, Western; D002648:Child; D002675:Child, Preschool; D015683:Gene Products, gag / Q000276:immunology*; D006801:Humans; D011233:Precipitin Tests; D012190:Retroviridae / Q000276:immunology*
D000906:Antibodies; D015683:Gene Products, gag