Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis).
Four mongrel dogs were intradermically inoculated with 3 x 10(6) Leishmania braziliensis braziliensis promastigotes. Three out of the four animals developed cutaneous lesions respectively 4, 7, and 8 months after. The fourth dog did not develop lesion at the inoculation site, but a mucosal ulcer was seen 16 months after the inoculum. Clinical, histopathological, and serological findings were similar to what is found in natural canine infection as well as in the human disease. These results suggest that dogs may be an useful model for L. b. braziliensis infection.
Pirmez
C
C
Instituto Oswaldo Cruz, Escola Nacional de Saúde Pública--FIOCRUZ, Rio de Janeiro, Brasil.
Marzochi
M C
MC
Coutinho
S G
SG
D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis*; D004285:Dogs; D005260:Female; D005455:Fluorescent Antibody Technique; D007891:Leishmania / Q000276:immunology*; D007892:Leishmania braziliensis / Q000276:immunology*; D007897:Leishmaniasis, Mucocutaneous / Q000175:diagnosis* / Q000473:pathology; D008297:Male
D000913:Antibodies, Protozoan