title: [Nuclear medicine prediction of histologic tumor response of osteosarcoma].
abstract: The prediction of histologic tumor response to preoperative chemotherapy was assessed by quantitative scintigraphic follow-up examinations of 54 osteosarcomas. Tumor/non-tumor scintimetry using 99mTc labeled diphosphonates allowed accurate prediction of tumor response in 28 of 30 tumors (accuracy = 93%) after completion and in 10 of 12 osteosarcomas (accuracy = 83%) at the half-way stage of preoperative chemotherapy evaluating only those tumors which showed convergent changes of tumor/non-tumor ratios in the perfusion and the mineral phase. At the half-way stage, however, evaluation of chemotherapy effects was complicated in 12 of 23 osteosarcomas by diverging T/NT ratios. In contrast, quantification and mapping of the tumor plasma volume and 99mTc MDP plasma clearance predicted the histologic tumor response to chemotherapy in 12 of 13 tumors (accuracy = 92%) after completion and in all 11 cases (accuracy = 100%) at the half-way stage.
authors.affiliation: Nuklearmedizinische Einrichtungen der Universitäten Hamburg.
authors.forename: J
authors.initials: J
authors.lastname: Knop
authors.forename: G
authors.initials: G
authors.lastname: Delling
authors.forename: M
authors.initials: M
authors.lastname: Salzer-Kuntschik
authors.forename: R
authors.initials: R
authors.lastname: Berberich
authors.forename: U
authors.initials: U
authors.lastname: Feine
authors.forename: H
authors.initials: H
authors.lastname: Feistel
authors.forename: R
authors.initials: R
authors.lastname: Ladenstein
authors.forename: W
authors.initials: W
authors.lastname: Müller-Schauenburg
authors.forename: O
authors.initials: O
authors.lastname: Schober
authors.forename: Z
authors.initials: Z
authors.lastname: Szabo
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002648:Child; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004164:Diphosphonates; D005260:Female; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D010865:Pilot Projects; D011379:Prognosis; D011877:Radionuclide Imaging; D013667:Technetium; D017556:Technetium Compounds
chemical_list: D004164:Diphosphonates; D017556:Technetium Compounds; D013667:Technetium; C029045:technetium Tc 99m diphosphonate
vernacular_title: Nuklearmedizinische Vorhersage des histologischen Tumoransprechens beim Osteosarkom.