title: Cyclosporin A in nontransplant-related liver disease.
abstract: Cyclosporin A is a potent immunosuppressive agent that has revolutionized the care of organ transplant recipients. Recently, the use of cyclosporin A has been extended beyond the transplant setting to include certain disorders that are thought to be immunologically mediated. This review focuses on the results of cyclosporin A in the treatment of nontransplant-related liver disorders including primary biliary cirrhosis, autoimmune chronic active (lupoid) hepatitis, primary sclerosing cholangitis, schistosomiasis, acute fulminant hepatitis, and chronic granulomatous liver disease.
authors.affiliation: Department of Medicine, University of Manitoba, Winnipeg, Canada.
authors.forename: G Y
authors.initials: GY
authors.lastname: Minuk
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy; D015209:Cholangitis, Sclerosing / Q000188:drug therapy; D003524:Cyclosporins / Q000627:therapeutic use*; D006521:Hepatitis, Chronic / Q000188:drug therapy; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000188:drug therapy; D008107:Liver Diseases / Q000188:drug therapy*
chemical_list: D003524:Cyclosporins