title: Xanthine oxidase status in ethanol-intoxicated rat liver.
abstract: The status of xanthine oxidase in ethanol-induced liver injury has been investigated in the rat, by acute and chronic ethanol treatments. A 38% increase of the enzyme O-form was observed after repeated ethanol administration. Chronic intoxication caused a significant decrease of total xanthine oxidase activity after both prolonged ethanol feeding and life span ethanol ingestion. The intermediate D/O-form of xanthine oxidase (that can act either as an oxidase or as a dehydrogenase, being able to react with O2 as well as with NAD+ as electron acceptor) increased 5.5-fold after prolonged ethanol feeding.
authors.affiliation: Dipartimento di Patologia Sperimentale, Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Abbondanza
authors.forename: M G
authors.initials: MG
authors.lastname: Battelli
authors.forename: M
authors.initials: M
authors.lastname: Soffritti
authors.forename: C
authors.initials: C
authors.lastname: Cessi
mesh_terms: D000435:Alcoholic Intoxication / Q000201:enzymology*; D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D005260:Female; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014969:Xanthine Oxidase / Q000378:metabolism*
chemical_list: D014969:Xanthine Oxidase