title: Recombinant human erythropoietin correction of anemia. Dialysis efficiency, waste retention, and chronic dose variables.
abstract: A clinical review of patients who were treated with recombinant human erythropoietin was undertaken to evaluate the effect of partial correction of anemia upon dialysis function and waste retention. Assessment of possible variables that might influence the dosage response was also undertaken, both in a retrospective and prospective manner. Finally, a chart review of patients' symptoms while on dialysis was done to evaluate the effect of correction of anemia. Hematologic improvement was noted in all patients placed on hormone therapy with the correction of hemoglobin and hematocrit. There was no effect on white cell count, although a slight change in the differential was noted at target and one year; platelets rose to a new steady state. Dialysis efficiency was decreased slightly for urea and markedly for creatinine, probable reflecting the distribution characteristics of the latter. Retention of urate, phosphorus, and potassium was noted at target, with a drop toward usual serum levels with minimal dialysis prescription change. Variables such as age, gender, race, and dialysis prescription were compared in an effort to establish dosage variation, but no statistically significant changes were seen. There was an inverse trend in dosage, however, with increasing dialysis efficiency. Patients also seemed to be more tolerant of their dialysis treatments when nonanemic, compared to when anemic. While there is retention of some substances with improvement of anemia, the levels were easily corrected with adjustment of the dialysis prescription. No definite relationship could be seen in any of the variables studied and hormone dose requirements. Attention must be paid to adequate dialysis prescription in the erythropoietin treated patient.
authors.affiliation: Department of Hypertension/Nephrology, Cleveland Clinic Foundation, OH 44195-5176.
authors.forename: E P
authors.initials: EP
authors.lastname: Paganini
authors.forename: M H
authors.initials: MH
authors.lastname: Abdulhadi
authors.forename: J
authors.initials: J
authors.lastname: Garcia
authors.forename: M O
authors.initials: MO
authors.lastname: Magnusson
mesh_terms: D000740:Anemia / Q000097:blood / Q000628:therapy*; D001772:Blood Cell Count; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004921:Erythropoietin / Q000008:administration & dosage*; D006400:Hematocrit; D006452:Hemoglobinometry; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic; D011994:Recombinant Proteins / Q000008:administration & dosage; D006435:Renal Dialysis / Q000379:methods*; D014508:Urea / Q000097:blood*
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin; D014508:Urea; D003404:Creatinine