title: Binding of drugs to alpha 1-acid glycoprotein and its desialylated form. Influence on hepatic disposition and implications for drug targeting to the liver.
authors.affiliation: Department of Pharmacology and Therapeutics, University Center of Pharmacy, Groningen, The Netherlands.
authors.forename: D K
authors.initials: DK
authors.lastname: Meijer
authors.forename: P
authors.initials: P
authors.lastname: van der Sluijs
mesh_terms: D000818:Animals; D037263:Asialoglycoprotein Receptor; D004705:Endocytosis / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D019158:N-Acetylneuraminic Acid; D009961:Orosomucoid / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D011971:Receptors, Immunologic / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D012794:Sialic Acids / Q000378:metabolism
chemical_list: D037263:Asialoglycoprotein Receptor; D009961:Orosomucoid; D004364:Pharmaceutical Preparations; D011971:Receptors, Immunologic; D012709:Serum Albumin; D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid