title: [Comparative studies of the effect of mictonorm (propiverin hydrochloride) and Spasuret (flavoxate hydrochloride) on the bladder detrusor muscle].
abstract: 46 patients suffering from urgency/urge incontinency were treated with Mictonorm and Spasuret in a crossing-over study. In consideration of the placebo effect in this disease both agents were tested versus a non-verum. The application period was 4 weeks and the dosage was 45 mg/d Mictonorm and 300 mg/d Spasuret, respectively. Both with Mictonorm and with Spasuret a significant reduction of micturition frequency and an increase of the compliance could be observed, whereas the placebo was ineffective. A markedly growth of the maximal bladder capacity (16.9%) was obtained only by Mictonorm. Both agents keep likewise to an improvement of the symptoms or urgency/urge incontinency. Side effects could observed in a small size without a breaking-off of the treatment.
authors.affiliation: Klinik für Urologie, Medizinischen Akademie Carl Gustav Carus, Dresden.
authors.forename: J
authors.initials: J
authors.lastname: Wehnert
authors.forename: S
authors.initials: S
authors.lastname: Sage
mesh_terms: D001561:Benzilates / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D005419:Flavonoids / Q000008:administration & dosage*; D005422:Flavoxate / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D010276:Parasympatholytics / Q000008:administration & dosage*; D001743:Urinary Bladder / Q000187:drug effects*; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy*; D014549:Urinary Incontinence / Q000188:drug therapy*; D014563:Urodynamics / Q000187:drug effects
chemical_list: D001561:Benzilates; D005419:Flavonoids; D010276:Parasympatholytics; D005422:Flavoxate; C015586:propiverine
vernacular_title: Vergleichende Untersuchungen zur Wirkung von Mictonorm (Propiverin hydrochlorid) und Spasuret (Flavoxat hydrochlorid) auf den Detrusor vesicae.