title: Advances in cyclosporine pharmacology, measurement, and therapeutic monitoring.
abstract: This review will focus on our current state of understanding of the cellular and molecular mechanisms by which CsA exerts immunosuppression and will present new information on: pharmacokinetic variability of CsA, selection of specimen and method for measuring CsA concentration, identity of CsA metabolites and their immunosuppressive and toxic activity, and the relationship between steady-state pre-dose concentrations of CsA in blood and response to treatment in transplant patients.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104.
authors.forename: L M
authors.initials: LM
authors.lastname: Shaw
mesh_terms: D003524:Cyclosporins / Q000032:analysis / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008991:Monitoring, Physiologic
chemical_list: D003524:Cyclosporins