title: Early renal ultrasonographic findings in dogs with experimentally induced ethylene glycol nephrosis.
abstract: Renal ultrasonographic changes were evaluated in 5 dogs administered 10 ml of commercial antifreeze (95% ethylene glycol)/kg of body weight, PO, and in 2 dogs given placebos. Studies were made prior to and after ingestion on an hourly basis over a period of 8 to 10 hours. All dogs were anesthetized immediately after toxin or placebo ingestion for the duration of the study. Renal cortical echogenicity was evaluated in comparison with that of the adjacent liver and spleen. Echogenicity of the renal medulla and definition of the corticomedullary junction were assessed. Within 4 hours after ethylene glycol administration, renal cortical echogenicity of all intoxicated dogs increased from normal to surpass that of liver and approach or equal that of the spleen. Medullary echogenicity in all intoxicated dogs progressively increased over the course of the study, with changes recognized within 5 hours after ethylene glycol administration. An ultrasonographic pattern consisting of nearly equal, marked increase in cortical and medullary echogenicity and relatively hypoechoic corticomedullary junction and central medullary regions was recognized concurrent with the development of anuria in 3 of the 5 intoxicated dogs. Mild, transient increases in cortical and medullary echogenicity were observed in anesthetized control dogs. However, no statistical difference (P less than 0.05) was detected between baseline, peak, and terminal echogenicity values in these dogs. Blood and urine samples were collected hourly from intoxicated dogs to coincide with ultrasonographic studies. Most clinicopathologic values derived from these samples were not statistically different (P less than 0.05) from those reported in a study that used a similar intoxication protocol in nonanesthetized dogs.
authors.affiliation: Department of Rural Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901.
authors.forename: W H
authors.initials: WH
authors.lastname: Adams
authors.forename: R L
authors.initials: RL
authors.lastname: Toal
authors.forename: M A
authors.initials: MA
authors.lastname: Walker
authors.forename: M A
authors.initials: MA
authors.lastname: Breider
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000139:chemically induced* / Q000175:diagnosis; D004285:Dogs; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000506:poisoning*; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009401:Nephrosis / Q000139:chemically induced / Q000175:diagnosis / Q000662:veterinary*; D013997:Time Factors; D014463:Ultrasonography / Q000662:veterinary*
chemical_list: D005026:Ethylene Glycols; D019855:Ethylene Glycol