Progression from steroid-responsive to unresponsive state in breast cancer.
Both steroid-responsive and unresponsive cancers can be identified at first presentation. Endocrine treatment produces remission that, however, is invariably followed by relapse. The role of steroids in the genesis of the pathways involved in producing a steroid-unresponsive cancer is discussed, as are its clinical implications using data from mammary tumour cell lines.
King
R J
RJ
Hormone Biochemistry Laboratory, Imperial Cancer Research Fund, London, UK.
D000818:Animals; D001943:Breast Neoplasms / Q000503:physiopathology*; D002460:Cell Line; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000503:physiopathology*; D013256:Steroids / Q000502:physiology
D013256:Steroids