[Verruciform xanthoma. Presentation of a case and review of the literature].
We describe a patient with a lesion on the nose, which clinically seemed a filiform wart; when the histological examination was performed we diagnosed a verruciform xanthoma. Looking at the literature we saw that the clinical diagnosis of this lesion had never been possible. Moreover, the histopathology always showed a peculiar pattern: a very dense infiltrate of foamy cells which completely removed the upper dermis and stopped at the basis of the rete ridges. Hyperlipemia was found in no cases, when specific tests were performed. Most cases reported were in the oral cavity. Age, sex and race do not seem to be relevant. The etiology of this lesion is unknown. Authors always discuss the pathogenesis, i.e. whether the first damage responsible for the formation of the foamy cells is in the epidermis or in the dermis. Other hypothesis have been suggested. Nevertheless, the majority of the Authors agree about the histiocytic origin of the xanthoma cells.
Manzini
B M
BM
Landthaler
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D003937:Diagnosis, Differential; D006801:Humans; D007642:Keratosis / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009668:Nose Diseases / Q000175:diagnosis / Q000473:pathology*; D009669:Nose Neoplasms / Q000175:diagnosis; D014860:Warts / Q000175:diagnosis; D014973:Xanthomatosis / Q000175:diagnosis / Q000473:pathology*
Xantoma verruciforme. Presentazione di un caso e revisione della letteratura.