Regulation of the Escherichia coli glyA gene by the metR gene product and homocysteine.
The methionine component of glyA gene regulation in Escherichia coli K-12 was investigated. The results indicate that the glyA gene is positively controlled by the metR gene product. Activation of glyA by the MetR protein requires homocysteine, an intermediate in methionine biosynthesis. The positive-acting metR regulatory system functions independently of a regulatory system shown previously to control glyA gene expression.
Plamann
M D
MD
Department of Microbiology, University of Iowa, Iowa City 52242.
Stauffer
G V
GV
D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D005786:Gene Expression Regulation; D005796:Genes / Q000187:drug effects; D005798:Genes, Bacterial / Q000187:drug effects; D005838:Genotype; D012696:Glycine Hydroxymethyltransferase / Q000096:biosynthesis / Q000235:genetics*; D006710:Homocysteine / Q000494:pharmacology*; D008715:Methionine; D009154:Mutation; D012486:Salmonella typhimurium / Q000235:genetics; D014166:Transferases / Q000235:genetics*
D006710:Homocysteine; D008715:Methionine; D014166:Transferases; D012696:Glycine Hydroxymethyltransferase