title: [Antigenic divergence in a primary rat hepatocyte culture after exposure to the hepatic carcinogen N-diethylnitrosamine].
abstract: Using the indirect immunofluorescence method, the appearance of membrane hetero-organic antigens of kidney origin associated with the Zajdela hepatoma cells was observed on the surface of cells of the rat liver primary culture following a single hepatocarcinogen N-diethylnitrosamine (DENA) treatment before and after explantation. A correlation of antigenic alterations after a single DENA treatment in vivo and in vitro was discovered. No antigens under investigation were discovered in cultured hepatocytes of intact adult rats.
authors.forename: I V
authors.initials: IV
authors.lastname: Nazarov
authors.forename: V A
authors.initials: VA
authors.lastname: Ivanov
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Fel'
mesh_terms: D000818:Animals; D000940:Antigenic Variation / Q000187:drug effects*; D015478:Antigens, Heterophile / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis; D002478:Cells, Cultured; D004052:Diethylnitrosamine / Q000633:toxicity*; D005455:Fluorescent Antibody Technique; D007668:Kidney / Q000276:immunology; D008099:Liver / Q000187:drug effects / Q000276:immunology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology; D008297:Male; D051381:Rats; D013997:Time Factors
chemical_list: D015478:Antigens, Heterophile; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D004052:Diethylnitrosamine
vernacular_title: Antigennaia divergentsiia v pervichnoĭ kul'ture gepatotsitov krys posle vozdeĭstviia gepatokantserogenom N-diétilnitrozaminom.