Nephrotoxicity of contrast media in patients with diabetes mellitus. A comparative urographic and angiographic study with iohexol and metrizoate.
A double-blind urographic and angiographic study was done with the ionic contrast medium meglumine metrizoate and the non-ionic iohexol in 90 patients with diabetes mellitus. Twenty patients were insulin dependent, and 70 non-insulin dependent diabetics. Diabetic patients with decreased as well as normal renal function prior to the examination sustained a reversible and small increase in the plasma creatinine level postexamination. The small increase caused by meglumine metrizoate was significantly higher than the increase caused by iohexol. There was also a significantly higher increase in plasma creatinine among the patients with diabetic nephropathy compared with those without nephropathy.
Billström
A
A
Department of Diagnostic Radiology, University Hospital, Umeå, Sweden.
Hietala
S O
SO
Lithner
F
F
Merikanto
J
J
Wirell
M
M
Wirell
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D002986:Clinical Trials as Topic; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000000981:diagnostic imaging*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000000981:diagnostic imaging*; D004311:Double-Blind Method; D006801:Humans; D007463:Iodobenzoates / Q000009:adverse effects*; D007472:Iohexol / Q000009:adverse effects*; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced*; D008794:Metrizoic Acid / Q000009:adverse effects* / Q000031:analogs & derivatives; D008875:Middle Aged; D011446:Prospective Studies; D014567:Urography
D007463:Iodobenzoates; D007472:Iohexol; D008794:Metrizoic Acid; C021342:methylglucamine metrizoate