A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles.
Neurofibrillary tangles and neuritic plaques are the neuropathological hallmarks of Alzheimer's disease. The latter consist of a core of A4 amyloid protein. We now report that some neurofibrillary tangles ('tombstone tangles') are also A4 immunoreactive. This observation is consistent with the hypothesis that A4 amyloid accumulation is a component of both neurofibrillary tangles and neuritic plaques.
Hyman
B T
BT
Department of Neurology, University of Iowa College of Medicine, Iowa City 52242.
Van Hoesen
G W
GW
Beyreuther
K
K
Masters
C L
CL
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000682:Amyloid / Q000378:metabolism*; D016229:Amyloid beta-Peptides; D006801:Humans; D007150:Immunohistochemistry; D009454:Neurofibrils / Q000378:metabolism* / Q000473:pathology
D000682:Amyloid; D016229:Amyloid beta-Peptides