Physiology and pharmacology of cerebral blood flow and metabolism.
In many critically ill patients, long-term neurologic outcome may depend on the adequacy of regional or global CBF. Despite this possibility, clinical protocols for the management of the cerebral circulation in acute neurologic disease have developed slowly. Perhaps progress in central nervous system monitoring, coupled with recent advances in cerebrovascular pharmacology, will alter the management and prognosis of patients with critical neurologic illness.
Prough
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Section on Critical Care, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Rogers
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AT
D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001927:Brain Diseases / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D003422:Critical Care; D006801:Humans; D010101:Oxygen Consumption; D010600:Pharmacology; D014655:Vascular Resistance