Monoclonal antibody immunoassay in the study of thrombogenicity of preclotted and gelatin-impregnated aortic prostheses.
The Dimertest Enzyme Immunoassay has been used to compare the degree of thrombogenicity of the standard knitted Dacron prosthesis (n = 10) and the gelatin-impregnated Dacron prosthesis (n = 10) after infrarenal aortic reconstruction. After surgery there was a similar rise in cross-linked fibrin degradation products with both types of prostheses. Although on the third day the D-Dimer level in the gelatin-impregnated prosthesis was lower, there was no significant difference in the D-Dimer level at six weeks. This suggests that the potential risk of thrombogenicity in the gelatin-impregnated prosthesis is similar to the standard preclotted type.
Zahrani
H A
HA
Peripheral Vascular Surgery Unit, Glasgow Royal Infirmary, Scotland.
Cuschieri
R J
RJ
Lowe
G D
GD
Douglas
J T
JT
Pollock
J G
JG
D000368:Aged; D000911:Antibodies, Monoclonal; D001012:Aorta, Abdominal / Q000601:surgery*; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D004796:Clinical Enzyme Tests; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology
D000911:Antibodies, Monoclonal; D005338:Fibrin Fibrinogen Degradation Products