Translational blockade imposed by cytokine-derived UA-rich sequences.
The messenger RNAs specifying certain proteins involved in the inflammatory response and certain oncoproteins contain a conserved UA-rich sequence in the 3' untranslated region. This sequence, which is composed of several interspersed repeats of the octanucleotide UUAUUUAU, has been shown to destabilize mRNA in some eukaryotes. However, this effect is not seen when mRNAs are transferred to Xenopus oocytes, which made it possible to separate stability from translational regulation. For interferon, granulocyte-macrophage colony-stimulating factor, and c-fos RNAs, the UA-rich sequence was observed to preclude mRNA translation.
Kruys
V
V
Département de Biologie Moléculaire, Université Libre de Bruxelles, Belgium.
Marinx
O
O
Shaw
G
G
Deschamps
J
J
Huez
G
G
D000818:Animals; D001483:Base Sequence; D003115:Colony-Stimulating Factors / Q000235:genetics*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000235:genetics*; D007370:Interferon Type I / Q000235:genetics*; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000378:metabolism
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D007370:Interferon Type I; D012333:RNA, Messenger; D016178:Granulocyte-Macrophage Colony-Stimulating Factor