Neoplastic meningitis in malignant melanoma: diagnosis with monoclonal antibodies.
Six patients with neoplastic melanomatous meningitis were studied. The diagnosis of this complication of malignant disease rests on the demonstration of malignant cells within the CSF. The addition of monoclonal antibody immunocytology to conventional techniques significantly improved the diagnostic sensitivity of CSF cytology, allowing for earlier and therefore more effective palliative treatment.
Moseley
R P
RP
Department of Neurosurgery, Frenchay Hospital, Bristol, UK.
Davies
A G
AG
Bourne
S P
SP
Popham
C
C
Carrel
S
S
Monro
P
P
Coakham
H B
HB
D000328:Adult; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D000951:Antigens, Neoplasm / Q000276:immunology; D002555:Cerebrospinal Fluid / Q000166:cytology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D058950:Melanoma-Specific Antigens; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D008578:Meninges / Q000473:pathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000276:immunology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins