Penicillin and clindamycin alter some group A streptococcal products.
The effects of subMICs of penicillin and clindamycin on group A streptococcal products were analyzed. Penicillin caused an increase in the expression of the group carbohydrate for the three strains tested; in contrast, clindamycin inhibited the expression in two strains. The M and T proteins were not affected by the drugs. Clindamycin caused an increase in the hyaluronidase activity and both antimicrobial agents inhibited the activity of streptolysin at 1/2 MIC.
Figueiredo
A M
AM
Streptococcal Reference Center, Federal University, Rio de Janeiro, Brazil.
Benchetrit
L C
LC
D000942:Antigens, Bacterial / Q000096:biosynthesis; D002981:Clindamycin / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects; D006821:Hyaluronoglucosaminidase / Q000096:biosynthesis; D010400:Penicillin G / Q000494:pharmacology*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D013301:Streptolysins / Q000378:metabolism
D000942:Antigens, Bacterial; D013301:Streptolysins; D002981:Clindamycin; D006821:Hyaluronoglucosaminidase; D010400:Penicillin G