Molecular basis of cisplatin resistance in human carcinomas: model systems and patients.
In this review, cisplatin resistance will be summarized. We will discuss characteristics of potential mechanisms of resistance in tissues from patients with ovarian, colon and breast carcinoma. Secondly, a new molecular biology assay will be discussed which detects changes in gene expression in cisplatin-resistant cells. Finally, based on the biochemical and molecular properties of cisplatin-resistant tumors, new strategies to exploit or circumvent cisplatin resistance in human tumors will be entertained.
Scanlon
K J
KJ
Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA 91010.
Kashani-Sabet
M
M
Miyachi
H
H
Sowers
L C
LC
Rossi
J
J
D002945:Cisplatin / Q000627:therapeutic use*; D004260:DNA Repair; D004261:DNA Replication; D004351:Drug Resistance; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D009857:Oncogenes; D013940:Thymidylate Synthase / Q000378:metabolism
D013940:Thymidylate Synthase; D002945:Cisplatin