[Magnesium--a new therapeutic alternative in primary dysmenorrhea].
50 patients suffering from primary dysmenorrhoea were treated with Magnesium (Mg 5-longoral, Artesan GmbH) in a double-blind study. After a six-month period 21 out of 25 women showed a decline of symptoms, only 4 ones reported no therapeutical effect. For monitoring treatment results prostaglandin F2 alpha (PGF2 alpha) was measured every second month. On Mg-therapy conditions we achieved a reduction of PGF2 alpha in menstrual blood to 45% of value before treatment started. As against that 90% of basic concentration were estimated from women who received a placebo. Probably, the specific therapeutical effect of Mg based on inhibition of biosynthesis of PGF2 alpha but also on its direct muscle relaxant and vasodilatory effect. Beside the PG-synthesis and ovulation inhibitors the use of Magnesium is a potential, natural opportunity to treat primary dysmenorrhoea, which is widely free of side effects.
Seifert
B
B
Klinik für Gynäkologie und Geburtshilfe, Medizinischen Akademie Magdeburg.
Wagler
P
P
Dartsch
S
S
Schmidt
U
U
Nieder
J
J
D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D015237:Dinoprost / Q000097:blood; D004311:Double-Blind Method; D004412:Dysmenorrhea / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use*
D001224:Aspartic Acid; D015237:Dinoprost; D008274:Magnesium
Magnesium--eine therapeutische Alternative bei der primären Dysmenorrhoe.