Competitive effects of long-chain-triglyceride emulsion on the metabolism of medium-chain-triglyceride emulsions.
This study was conducted to assess the potential metabolic competitive interactions of intravenous medium-chain-triglyceride (MCT) and long-chain-triglyceride (LCT) lipid emulsions. To assess this competition increasing concentrations of LCT emulsion were added to an intravenous dose of MCT emulsion of 3.0 g/kg body wt up to a maximum dose of 3.0 g LCTs/kg body wt. Blood samples were assessed for competitive interactions by analyzing the following metabolites: glucose, insulin, lactate, pyruvate, ketones (acetoacetate, beta-hydroxybutyrate), elimination of triglycerides, and free fatty acids. Evaluation of the data showed a strong competitive interaction between the MCT and LCT emulsions. This competition was evident as soon as LCTs were added to the MCT infusions and appeared to favor LCTs for removal and metabolism over MCTs. This appears to indicate that there is a peripheral, strong affinity site for LCT removal and metabolism and a shared peripheral site and specific visceral site for MCT removal and metabolism.
Cotter
R
R
Baxter Healthcare Corporation, Round Lake, IL.
Johnson
R C
RC
Young
S K
SK
Lin
L I
LI
Rowe
W B
WB
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D001667:Binding, Competitive; D001786:Blood Glucose / Q000032:analysis; D004285:Dogs; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007328:Insulin / Q000032:analysis; D007659:Ketones / Q000032:analysis; D007773:Lactates / Q000032:analysis; D008657:Metabolic Clearance Rate; D011773:Pyruvates / Q000032:analysis; D013997:Time Factors; D014280:Triglycerides / Q000008:administration & dosage / Q000493:pharmacokinetics*
D001786:Blood Glucose; D005217:Fat Emulsions, Intravenous; D007328:Insulin; D007659:Ketones; D007773:Lactates; D011773:Pyruvates; D014280:Triglycerides