title: Kininogens, kinins and kinships.
abstract: This article reviews most recent developments in the field of the multifunctional kininogens which are involved in major physiologic systems such as the blood coagulation cascade, the inflammatory reaction, the inhibitor defense mechanism, and the acute phase response. Particular attention is given to the interaction of kininogens with endothelial cells and platelets, the post-translational modification of kinin(ogen)s by proline hydroxylase, and the placing of kininogens among structurally and functionally related plasma proteins.
authors.affiliation: Department of Clinical Chemistry and Clinical Biochemistry, University of Munich, FRG.
authors.forename: W
authors.initials: W
authors.lastname: Müller-Esterl
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D006801:Humans; D006900:Hydroxylation; D007704:Kininogens / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D007705:Kinins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data
chemical_list: D007704:Kininogens; D007705:Kinins