Radiation-associated cerebral gliomas. A report of two cases and review of the literature.
Two cases are reported in which a cerebral glioma developed after radiation therapy for a different primary tumor. The first case was a boy, who presented a right thalamic anaplastic astrocytoma 7 years after irradiation for a left temporal polymorphic cell sarcoma. The second case was a woman, with a right temporal anaplastic astrocytoma occurring 8 years after irradiation for a GH-secreting pituitary adenoma. Thirty-five other cases of radiation-associated cerebral gliomas had already been reported in the literature. The possible causal role of radiation therapy in inducing cerebral gliomas is discussed on the basis of these observations.
Zampieri
P
P
Division of Neurosurgery, General Hospital, Padova, Italy.
Zorat
P L
PL
Mingrino
S
S
Soattin
G B
GB
D000236:Adenoma / Q000532:radiotherapy; D001254:Astrocytoma / Q000000981:diagnostic imaging / Q000473:pathology*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002648:Child; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000532:radiotherapy; D011859:Radiography; D012509:Sarcoma / Q000532:radiotherapy