title: An immunocytochemical study on the distribution of ferritin and other markers in 36 cases of malignant histiocytosis.
abstract: The distribution of ferritin in 36 autopsy cases of malignant histiocytosis was investigated by immunocytochemical staining, together with the detection of alpha 1-antichymotrypsin, alpha 1-antitrypsin, lysozyme, S-100 protein, and ricinus communis agglutinin in the consecutive sections. The results showed that ferritin-positive tumor cells were present in every case. The quantity of cellular ferritin in well-differentiated histiocytes was higher than that in atypical histiocytes. Double labeling showed that ferritin and alpha 1-antichymotrypsin might be located either in one tumor cell or in separate cells. Our data suggest that ferritin may be a tumor associated antigen in malignant histiocytosis, playing a regulatory role for tumor cell differentiation.
authors.affiliation: Department of Pathology, Fourth Military Medical College, Shaanxi, People's Republic of China.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Ji
authors.forename: Y F
authors.initials: YF
authors.lastname: Liu
authors.forename: B Y
authors.initials: BY
authors.lastname: Wang
authors.forename: D Y
authors.initials: DY
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D005293:Ferritins / Q000032:analysis*; D054747:Histiocytic Sarcoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008938:Mitosis; D009113:Muramidase / Q000032:analysis; D010587:Phagocytosis; D009418:S100 Proteins / Q000032:analysis; D000514:alpha 1-Antichymotrypsin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D009418:S100 Proteins; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D005293:Ferritins; D009113:Muramidase