MRS of the kidney.
Many of the first magnetic resonance spectroscopy (MRS) studies ever conducted on intact biologic tissues were on the mammalian kidney. These early studies and subsequent investigations have concentrated on the evaluation of the viability and metabolic function of the kidney in vitro and in vivo. This brief overview will discuss the type of information that has been obtained on the kidney, using model systems as well as man. In these studies, MRS has provided new physiologic and biochemical data on the kidney. These include the determination of the heterogeneity of intracellular pH and the discovery of organic solutes that protect the kidney from the hostile extracellular environment it manufactures. Clinical studies have been precipitated by favorable model studies, but are still in early stages of development.
Balaban
R S
RS
Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, Bethesda, MD 20892.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D006801:Humans; D006859:Hydrogen; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D010710:Phosphates / Q000378:metabolism; D010758:Phosphorus; D012964:Sodium
D010710:Phosphates; D010758:Phosphorus; D006859:Hydrogen; D000255:Adenosine Triphosphate; D012964:Sodium