title: A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles.
abstract: Neurofibrillary tangles and neuritic plaques are the neuropathological hallmarks of Alzheimer's disease. The latter consist of a core of A4 amyloid protein. We now report that some neurofibrillary tangles ('tombstone tangles') are also A4 immunoreactive. This observation is consistent with the hypothesis that A4 amyloid accumulation is a component of both neurofibrillary tangles and neuritic plaques.
authors.affiliation: Department of Neurology, University of Iowa College of Medicine, Iowa City 52242.
authors.forename: B T
authors.initials: BT
authors.lastname: Hyman
authors.forename: G W
authors.initials: GW
authors.lastname: Van Hoesen
authors.forename: K
authors.initials: K
authors.lastname: Beyreuther
authors.forename: C L
authors.initials: CL
authors.lastname: Masters
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000682:Amyloid / Q000378:metabolism*; D016229:Amyloid beta-Peptides; D006801:Humans; D007150:Immunohistochemistry; D009454:Neurofibrils / Q000378:metabolism* / Q000473:pathology
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides