[Homografts in the human brain. Current data].
Since 1982, grafting of human nervous tissue on human central nervous system has been realized, mainly in Parkinson's disease. The present article reviews the theoretical basis of such procedures, i.e., the remarkable experimental work that began around the turn of the century. New approaches, e.g., using hydroxydopamine or MTPP, have greatly enlarged the field of experimental research. In man, grafts of adrenal medulla and, in a few cases, of fetal substantia nigra, have been realized in several hundreds of patients. The known results invite great caution. Brain grafting has also been considered in Huntington's chorea, trauma of the spinal cord and even schizophrenia. In animals, transplants of hypothalamus and pre-optic area have counteracted genetic endocrine disorders. Experimental researches are of high interest but their application to man raises major problems of efficiency and fundamental ethical and legal questions.
Gautier
J C
JC
D000818:Animals; D006801:Humans; D009417:Nerve Tissue / Q000637:transplantation*; D010300:Parkinson Disease / Q000601:surgery*; D014184:Transplantation, Homologous
Homogreffes dans le cerveau humain. Données actuelles.