[Comparative study of short-term antimicrobial chemoprophylaxis in gynecologic surgery: cefotetan versus cefazolin].
The results obtained in 80 patients hospitalized at the University of Obstetrics and Gynecology Clinic in Perugia for abdominal and vaginal hysterectomy are reported and evaluated in a prospective and randomized study of perioperative antibacterial prophylaxis. In the 75 patients available to study a single intravenous dose of 2 g cefotetan was compared with a triple dose of 1 g intravenous cephazolin. A reduction in the incidence of post-operative infections both in abdominal hysterectomy from 24% (cephazolin group) to 11.53% (cefotetan group) and in vaginal hysterectomy from 40% (cephazolin group) to 71.4% (cefotetan group) was noted. These results show that a single intravenous dose of 2 g cefotetan can be considered a valid therapeutic support for antibacterial prophylaxis. In addition the absence of alterations in the parameters considered (haematological, biochemical and urinary) points to the safety, effectiveness and non-toxicity of the drug.
Baldoni
A
A
Cosco
A G
AG
Epicoco
G
G
Affronti
G
G
Giannone
E
E
Gilardi
G
G
D000890:Anti-Infective Agents / Q000008:administration & dosage; D002437:Cefazolin / Q000008:administration & dosage*; D015313:Cefotetan / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D007044:Hysterectomy; D007275:Injections, Intravenous; D011182:Postoperative Care; D011300:Preoperative Care; D013530:Surgical Wound Infection / Q000517:prevention & control*
D000890:Anti-Infective Agents; D015313:Cefotetan; D002437:Cefazolin
Studio comparativo di chemioprofilassi antimicrobica a breve termine in chirurgia ginecologica: cefoteta versus cefazolina.