[Endoscopic studies of gastroduodenal tolerance of 100 mg versus 500 mg acetylsalicylic acid daily: a randomized double-blind study with healthy probands].
Acetylsalicylic acid (ASS) is increasingly used in the prevention of cardiovascular diseases. In recent years lower daily ASS-doses (100-300 mg) have been given for this indication. However, only marginal knowledge is available about the upper GI-tolerability of ASS in this dosage regiment. In a randomized double-blind study we have evaluated the gastroduodenal tolerability of 100 mg ASS and 500 mg ASS daily in 20 healthy volunteers using upper GI-endoscopy. Both ASS-dosages have been taken over a period of 4 weeks. Endoscopic controls were performed at entry and repeated after 7, 14 and 28 days of treatment. 100 mg ASS daily induced during the whole period significant less gastroduodenal damages than 500 mg ASS daily (p less than 0.05). The lesion score of both groups on day 7 and day 28 were almost identical. Our data suggest that even low doses of ASS (100 mg daily) produced gastroduodenal injuries and that no adaptative phenomena did occur during the treatment period.
Müller
P
P
Medizinische Universitätsklinik Heidelberg, Gastroenterologische Abteilung.
Dammann
H G
HG
Marinis
E
E
Simon
B
B
D000328:Adult; D001241:Aspirin / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004386:Duodenum / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects*; D008297:Male; D016032:Randomized Controlled Trials as Topic
D001241:Aspirin
Endoskopische Untersuchungen zur gastroduodenalen Verträglichkeit von 100 mg versus 500 mg Azetylsalizylsäure täglich: Eine randomisierte Doppelblindstudie an gesunden Probanden.