[State of insulin receptors and carbohydrate metabolism in children with diabetes mellitus].
Diabetes mellitus children demonstrate the lowering of insulin binding by lymphocytes on appearance of the signs of insulin overdosage. After standard breakfast preceded by insulin injection such patients show a lower blood content of ATP as compared to children without metabolic signs of insulin overdosage, which may be of importance in the pathogenesis of insulin resistance development. Patients with type I diabetes mellitus and hyperlactatemia manifested the lowering of glucose assimilation by lymphocytes whatever the presence of the signs of insulin overdosage, pointing to insulin resistance.
Vakhrusheva
L L
LL
Mikaelian
N P
NP
Kniazev
Iu A
IuA
Sergeeva
N A
NA
D000255:Adenosine Triphosphate / Q000097:blood; D000293:Adolescent; D050260:Carbohydrate Metabolism; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000378:metabolism*; D007333:Insulin Resistance; D007773:Lactates / Q000097:blood; D008214:Lymphocytes / Q000378:metabolism; D011972:Receptor, Insulin / Q000032:analysis*
D000255:Adenosine Triphosphate; D006442:Glycated Hemoglobin; D007328:Insulin; D007773:Lactates; D011972:Receptor, Insulin
Sostoianie insulinovykh retseptorov i uglevodnogo obmena u deteĭ, bol'nykh sakharnym diabetom.