title: Role of Ca2+ in toxic cell killing.
abstract: Recent work has shown that a sustained increase in cytosolic Ca2+ concentration is often linked to the onset of cytotoxicity. Sten Orrenius and colleagues describe several biochemical mechanisms that are stimulated by such a Ca2+ increase and can directly mediate cell death by causing disruption of the cytoskeleton, DNA fragmentation and extensive damage to other cell components.
authors.forename: S
authors.initials: S
authors.lastname: Orrenius
authors.forename: D J
authors.initials: DJ
authors.lastname: McConkey
authors.forename: G
authors.initials: G
authors.lastname: Bellomo
authors.forename: P
authors.initials: P
authors.lastname: Nicotera
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D002470:Cell Survival; D006801:Humans
chemical_list: D002118:Calcium