[Oncogenes and arterial hypertension].
Phospholipase C activity governs translocation of Ca2+ from intracellular sites of storage via IP3 (inositol triphosphate) and cell differentiation and growth via DG (diacylglycerol). Phospholipase C responsiveness to various agonists (thrombin, angiotensin II, growth factor) was shown to be increased in various tissues of SHR as compared to WKY (platelets, aortic cultured smooth muscle cells, aortic fibroblasts). The constancy of the response and its physiological significance suggest that this membrane biochemical change plays a crucial role in the pathogenesis of hypertension. Phospholipase C responsiveness was also tested in platelets of untreated hypertensive patients. Half of the sample exhibited an hyperreactivity similar to that observed in SHR rats. This finding confirms the heterogeneity of human essential hypertension and suggests that a proportion of patients have a biological pattern close to that of SHR.
Meyer
P
P
INSERM U 7 et CNRS UA 318, Département de Pharmacologie, Hôpital Necker, Paris.
D000818:Animals; D002455:Cell Division; D006973:Hypertension / Q000201:enzymology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D009857:Oncogenes; D051381:Rats; D010738:Type C Phospholipases / Q000235:genetics / Q000378:metabolism*
D010738:Type C Phospholipases
Oncogènes et hypertension artérielle.