[The application of insulin-agar embedding in suppositories for controlled hormone liberation and dose lowering].
By embedding of insulin in agar a significant retardation as well as a protective effect for the hormone is obtained. As demonstrated on in vivo animal experiments, this embedding method in dependence on the insulin concentration and particle size of the polymeric matrix allows to prepare rectal insulin applications with remarkable depot effects. Alternatively in combination with resorption promoting tensides it permits to lower the administered hormone doses to a order of magnitude reaching those used for parenteral insulin applications.
Losse
G
G
Sektion Chemie der Technischen Universität Dresden, Wissenschaftsbereich Lebensmittelchemie und Technische Biochemie.
Müler
F
F
Kossowicz
J
J
Hacker
E
E
D000362:Agar; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D007328:Insulin / Q000008:administration & dosage* / Q000032:analysis; D011817:Rabbits; D013488:Suppositories
D001786:Blood Glucose; D007328:Insulin; D013488:Suppositories; D000362:Agar
Uber die Verwendung von Insulin-Agar-Einbettungen in Suppositorien zur verzögerten Hormonliberation und Dosissenkung.