title: [Somatomedins: growth and differentiation factors. Clinical implications].
abstract: This review focuses on the action of somatomedins IGF-1 and IGF-2, and in particular the role of IGF-1 in cell multiplication and differentiation. A brief overview is given of the factors controlling IGF-1 flow rate expression in the tissues. Factors influencing IGF-1 plasma levels, i.e. age, and insufficiency or excess of growth hormone, are discussed.
authors.affiliation: INSERM U 307, hôpital Debrousse, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Chatelain
authors.forename: M
authors.initials: M
authors.lastname: Nicolino
authors.forename: L
authors.initials: L
authors.lastname: De Parscau
authors.forename: J
authors.initials: J
authors.lastname: Saez
authors.forename: R
authors.initials: R
authors.lastname: Francois
mesh_terms: D000375:Aging / Q000502:physiology; D002454:Cell Differentiation; D002455:Cell Division; D005260:Female; D013006:Growth Hormone / Q000502:physiology; D006801:Humans; D011247:Pregnancy; D011627:Puberty / Q000502:physiology; D011863:Radioimmunoassay; D013002:Somatomedins / Q000032:analysis / Q000235:genetics / Q000502:physiology*
chemical_list: D013002:Somatomedins; D013006:Growth Hormone
vernacular_title: Somatomédines: facteurs de croissance et différenciation. Implications cliniques.