Release of mutagens from finished leather.
Extracts of a leather widely used in the furniture and dress-making industries were tested for their mutagenic activity in the Salmonella/microsome assay. Extracts obtained after vigorous treatment of leather samples in a Soxhlet apparatus with toluene or ethanol were mutagenic in strain TA98 of S. typhimurium in the absence of S9 mix. The analysis of extracts of leather at various intermediate stages of processing showed that the mutagenic activity appeared after the coloration process. The responsible compound was identified to be an azo dye (Color Index: Acid Brown 83) whose mutagenic potency was about 4 revertants/micrograms.
Clonfero
E
E
Institute of Occupational Health, University of Padua, Italy.
Montini
R
R
Venier
P
P
Levis
A G
AG
D001391:Azo Compounds / Q000633:toxicity*; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D009152:Mutagenicity Tests; D009153:Mutagens / Q000493:pharmacokinetics; D012486:Salmonella typhimurium / Q000235:genetics; D012775:Shoes; D013633:Tanning
D001391:Azo Compounds; D009153:Mutagens