Lipid abnormalities and diuretics.
Diuretic-based treatment regimens for hypertension have consistently reduced blood pressure and the morbidity and mortality due to stroke and overall cardiovascular disease. Studies have been less consistent in showing a beneficial effect on morbidity and mortality from coronary heart disease. However, speculations that possible adverse effects of diuretics on lipids may have contributed to the lack of a consistent beneficial effect on coronary heart disease are not substantiated by long-term clinical trials.
Moser
M
M
Yale University School of Medicine, New Haven, Connecticut.
D001581:Benzothiadiazines; D002318:Cardiovascular Diseases / Q000097:blood / Q000188:drug therapy*; D002784:Cholesterol / Q000097:blood*; D004232:Diuretics; D005260:Female; D006801:Humans; D008297:Male; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects*
D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D002784:Cholesterol