title: Management of human keratomycosis with miconazole.
abstract: A prospective clinical study was undertaken to evaluate the efficacy of 1% miconazole in 85 cases of smear-positive fungal corneal ulcers. Miconazole therapy healed 44 ulcers, thereby achieving a success rate of 64.7%. The most common organism encountered was Aspergillus followed by Fusarium, Philophora and Candida. The average healing time was found to be 22 days. The drug was well tolerated by the eye and no symptoms of ocular toxicity were observed. The findings of this study suggest that miconazole is an effective agent for the management of human keratomycosis.
authors.affiliation: Division of Ocular Pharmacology, All India Institute of Medical Sciences, New Delhi.
authors.forename: M
authors.initials: M
authors.lastname: Mohan
authors.forename: A
authors.initials: A
authors.lastname: Panda
authors.forename: S K
authors.initials: SK
authors.lastname: Gupta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003320:Corneal Ulcer / Q000145:classification / Q000382:microbiology / Q000628:therapy*; D015821:Eye Infections, Fungal / Q000382:microbiology / Q000628:therapy*; D005260:Female; D005658:Fungi / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008825:Miconazole / Q000627:therapeutic use*; D008875:Middle Aged; D009181:Mycoses / Q000382:microbiology / Q000628:therapy*; D011446:Prospective Studies; D014792:Visual Acuity
chemical_list: D008825:Miconazole