title: A double-blind, placebo-controlled trial of high doses of gangliosides in amyotrophic lateral sclerosis.
abstract: We performed a 3-month, double-blind, placebo-controlled trial of 300 mg of gangliosides (Cronassial) in 40 outpatients with amyotrophic lateral sclerosis (ALS). We evaluated drug effect through physical examinations and symptom scales. Though this dosage had no major toxic effect, Cronassial treatment did not significantly benefit ALS patients.
authors.affiliation: Department de Pharmacologie Clinique Group, Hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Lacomblez
authors.forename: P
authors.initials: P
authors.lastname: Bouche
authors.forename: G
authors.initials: G
authors.lastname: Bensimon
authors.forename: V
authors.initials: V
authors.lastname: Meininger
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005732:Gangliosides / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D010919:Placebos
chemical_list: D005732:Gangliosides; D010919:Placebos