[Inhibition of Candida albicans transformation from the yeast form to the mycelial form by 2-alkylthio-6-amino- and 2-alkylthio-6-formamido- benzothiazoles].
The inhibitory effectiveness of 2-alkylthio-6-amino- and 2-alkylthio-6-formamidobenzothiazoles (19 derivatives altogether) on the transformation of the yeast-like form of Candida albicans into the mycelial form (1 strain from the collection and 2 clinical isolates) was investigated. Most derivatives tested, similarly as the standard 2-mercaptobenzothiazole (Dermacid), did not exert any difference between the inhibitory effectiveness on filamentation and the inhibition of the growth and reproduction of the yeast-like form. However, the best derivative, 6-amino-2-n-pentylthiobenzothiazole, showed as much as 25-fold higher inhibitory effectiveness on the transformation of the yeast-like form into the mycelial one than MIC.
Kuchta
T
T
Straková
H
H
Sidóová
E
E
D000588:Amines / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D005559:Formamides / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
D000588:Amines; D005559:Formamides; D013844:Thiazoles
Inhibícia transformácie kvasinkovitej formy Candida albicans na mycéliovú formu 2-alkyltio-6-amino- a 2-alkyltio-6-formamidobenzotiazolmi.