An update on digoxin.
This review deals briefly with recent developments in the therapeutic drug monitoring of digoxin. Strategies for decreasing the interference by digoxin metabolites, digoxin-like factors, and spironolactone metabolites in immunoassays of digoxin are discussed. Other issues addressed include the development of alternative methods of analysis, such as receptor assays and "high-pressure" liquid chromatography; digoxin-like factors in hypertension; drug-drug interactions; redistribution of digoxin stores in the body; and forensic considerations.
Stone
J A
JA
Children's Hospital National Medical Center Research Foundation, Washington, DC 20010.
Soldin
S J
SJ
D004077:Digoxin / Q000627:therapeutic use*; D006801:Humans; D008991:Monitoring, Physiologic
D004077:Digoxin