Sensory and motor deficits of central nervous system origin.
The sensory and motor deficits of the CNS are varied, depending on the etiologic factors and the structures involved. Nevertheless, the clinical picture is predictable, provided one has an adequate knowledge of the neuroanatomy and the functions of the different fiber tracts, nuclei, and other specific regions of the brain and spinal cord. The purpose of this section is to provide an overall view of the sensory and motor deficits of the CNS, which will enable the clinician to treat these patients in a more objective and effective manner. Etiologically, the diseases affecting the CNS can be grouped under the following categories: congenital, traumatic, inflammatory, neoplastic, and degenerative. Congenital conditions usually manifest in infancy and childhood. Examples are hydrocephalus, spina bifida, and Arnold-Chiari malformation. There are a host of other conditions, but the discussion in this article is confined to the more common entities. Traumatic conditions such as cerebral concussion, contusion, laceration, hematomas--extradural, subdural, or intracerebral--and spinal cord injuries can occur in any age group, though their incidence is higher during the more active period of life (20 to 35 years). Automobile accidents are by far the most common etiologic factor for the traumatic lesions. Others, such as falls, gunshot and stab wounds, and so forth account for the remainder. Among the inflammatory conditions, three conditions are important: brain abscess, meningitis, and transverse myelitis. Though brain abscess develops by direct extension from an adjacent focus of infection, often it forms as a result of metastatic infection, chiefly from lung abscess or bronchoectasis. It behaves more like an intracranial space occupying lesion. Of the various types of meningitis, meningococcal meningitis is the commonest. Transverse myelitis may be caused by viruses or bacteria. The clinical picture resembles that of spinal cord injury. Neoplasms of the brain and spinal cord present a wide and varied spectrum. They may be benign or malignant. Meningioma and neurofibroma are essentially benign lesions. Malignant tumors can be primary or secondary. Gliomas and specifically astrocytomas are the commonest primary malignant tumors. The commonest sites of metastatic tumors are lung, breast, kidney, and gastrointestinal tract. The clinical picture will depend on the location of the tumor and the structures pressed upon or infiltrated. Any age group can be affected. Many of the malignant tumors are slowly and relentlessly progressive. Complete surgical extirpation where possible, followed by radiation therapy, is the treatment of choice. Chemotherapy has not been of much benefit.(ABSTRACT TRUNCATED AT 400 WORDS)
Aravabhumi
S
S
Temple University School of Medicine, Philadelphia, Pennsylvania.
Izzo
K L
KL
D000328:Adult; D002490:Central Nervous System / Q000033:anatomy & histology / Q000502:physiology / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000145:classification / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D007866:Leg / Q000294:innervation*; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology*; D009369:Neoplasms / Q000150:complications; D011379:Prognosis; D012677:Sensation; D012737:Sex Factors