title: [A double-blind comparative study of intracoronary administration of GE-0943 and urokinase: multicenter study].
abstract: Coronary thrombolysis with plasminogen proactivator, GE-0943, was undertaken in patients with acute myocardial infarction and compared with urokinase. Fifty patients were given 6000 units of GE-0943 intracoronary and the totally occluded infarct-related arteries were recanalized in 92.0%. Fifty-four patients who were given 3000 units of GE-0943 intracoronary demonstrated a recanalization rate of 68.2%, while intracoronary administration of urokinase in 54 patients showed a recanalization rate of 70.4%. There was only one patient with hemorrhagic complication among GE-0943 3000-units group, none among GE-0943 6000-units group, and 5 among urokinase group. Thus, intracoronary administration of GE-0943 is very effective and safe with a dose up to 6000 units.
authors.forename: H
authors.initials: H
authors.lastname: Kambara
authors.forename: C
authors.initials: C
authors.lastname: Kawai
authors.forename: N
authors.initials: N
authors.lastname: Kajiwara
authors.forename: K
authors.initials: K
authors.lastname: Kammatsuse
authors.forename: H
authors.initials: H
authors.lastname: Nitani
authors.forename: S
authors.initials: S
authors.lastname: Sasayama
authors.forename: K
authors.initials: K
authors.lastname: Kodama
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Nobuyoshi
authors.forename: M
authors.initials: M
authors.lastname: Nakashima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004792:Enzyme Precursors / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009203:Myocardial Infarction / Q000188:drug therapy*; D010960:Plasminogen Activators / Q000008:administration & dosage / Q000627:therapeutic use*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D004792:Enzyme Precursors; C011074:plasminogen proactivator; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator