[Reduction of mortality in acute myocardial infarction with streptokinase and aspirin therapy. Results of ISIS-2].
This investigation includes 17,187 patients in 417 hospitals in 16 countries admitted within 24 hours of the commencement of symptoms of acute myocardial infarction (AMI). The patients were allotted at random to the following treatments 1) intravenous infusion of 1.5 million International Units streptokinase (SK) during one hour, 2) 160 mg acetyl salicylic acid (ASA) daily for 30 days, 3) both SK and ASA and 4) placebo treatment only. The five-week cardiovascular mortality was reduced by 25% following infusion of streptokinase from 12.0% to 9.2% and by 23% during ASA treatment from 11.8% to 9.4%. The combination of SK and ASA resulted in 42% reduction in the cardiovascular mortality after five weeks compared with the placebo. The effect of SK was greatest if treatment was instituted within six hours but effects were obtained after all of the first 24 hours. The preliminary results show that the reduction in mortality obtained by both SK and ASA appears to continue during the subsequent one to two years. SK treatment resulted in haemorrhage requiring treatment in 0.5% as compared with 0.2% in the placebo group, more cases of proved cerebral haemorrhage, 0.1% as compared with 0.0%, but fewer cases of cerebral apoplexy, 0.7% as compared with 0.8%. It is concluded that thrombolysis with SK combined with prophylaxis of repeated thrombosis with ASA is the indicated treatment in cases of AMI and less than 6-24 hours duration.
Madsen
J K
JK
Pedersen
F
F
Amtoft
A
A
Deding
A
A
Grande
P
P
Hansen
J N
JN
Hilden
M
M
Hornum
I
I
Jensen
T
T
Lindskov
J
J
D000368:Aged; D001241:Aspirin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009203:Myocardial Infarction / Q000150:complications / Q000401:mortality*; D011897:Random Allocation; D013300:Streptokinase / Q000627:therapeutic use*; D013927:Thrombosis / Q000517:prevention & control*
D004338:Drug Combinations; D013300:Streptokinase; D001241:Aspirin
Mortalitetsreduktion med streptokinase og acetylsalicylsyrebehandling ved akut myokardieinfarkt. Resultater af ISIS-2.