Menhaden-fish oil in a vitamin E-deficient diet: protection against chloroquine-resistant malaria in mice.
Feeding a vitamin E-deficient diet containing 5% menhaden oil to mice affords significant protection against both a chloroquine-sensitive and a chloroquine-resistant line of the malarial parasite. Nutritional manipulation may offer a new approach to the problem of drug-resistant malaria, a rapidly emerging global threat to public health.
Levander
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Beltsville Human Nutrition Research Center, US Department of Agriculture, MD 20705.
Ager
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Morris
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May
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D000818:Animals; D002738:Chloroquine / Q000494:pharmacology; D004032:Diet; D004351:Drug Resistance; D005395:Fish Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D008288:Malaria / Q000517:prevention & control*; D008297:Male; D051379:Mice; D010963:Plasmodium falciparum / Q000187:drug effects; D014810:Vitamin E / Q000008:administration & dosage*; D014811:Vitamin E Deficiency
D005395:Fish Oils; D014810:Vitamin E; C033266:Menhaden oil; D002738:Chloroquine