title: [The rate of injection of succinylcholine and onset of neuromuscular action, serum potassium or myoglobin levels. Studies in men during halothane anesthesia].
abstract: Succinylcholine was injected at different speeds to 60 men in halothane anesthesia, to see whether the rate of injection influenced the effects. METHODS. Sixty men (ASA I and II, mean age 28.6 years) undergoing surgery without muscle trauma were studied. They were treated uniformly with respect to premedication, anesthesia, venipuncture (cubital), and concentration (1%) and dosage (1 mg/kg) of succinylcholine (SCh). The only difference lay in the speed of injection of the relaxant: 20 mg/s, 8 mg/s, 4 mg/s, 2 mg/s and 1 mg/s, 12 patients being randomly allocated to each. The injection rate was controlled by a preprogrammed microprocessor pump system (XD 5500, HC Ulrich, D-7900 Ulm, Donau). The neuromuscular transmission was monitored by the adductor pollicis twitch technique using indirect supramaximal stimulation (Accelograph, biometer, DK-5120 Odense). The recorded twitch response allowed determination of the total onset time (TOT) from the beginning of the injection to the maximal twitch depression, its components, latent and manifest onset times (LOT and MOT), and the twitch depression factor ki. Blood samples for measurement of potassium and myoglobin levels (RIA, sensitive to 5 ng/ml) were taken before and 5, 15, and 30 min after SCh administration. For determination of the course (difference between two values before and after SCh), the maximum level up to 30 min was recorded. RESULTS. The twitch depression amounted to 100% in 57 patients and to 93% or 98% in the remaining 3. Reducing the speed of injection led to significant prolongation of TOT and LOT (Table 3) and significant differences in the onset characteristic in regard to twitch depression factor ki (Table 4). No significant influence on the increase in potassium (Table 7) and myoglobin (Table 8) was observed. CONCLUSION. These findings give no cause to inject SCh more slowly than usual in healthy adults.
authors.affiliation: Institut für Anaesthesiologie, Klinikum Bamberg.
authors.forename: J
authors.initials: J
authors.lastname: Plötz
authors.forename: N
authors.initials: N
authors.lastname: Kutz
authors.forename: C
authors.initials: C
authors.lastname: Sommerburg
authors.forename: J
authors.initials: J
authors.lastname: Braun
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D002986:Clinical Trials as Topic; D006221:Halothane; D006801:Humans; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood*; D009469:Neuromuscular Junction / Q000187:drug effects*; D011188:Potassium / Q000097:blood*; D011897:Random Allocation; D013390:Succinylcholine / Q000008:administration & dosage*
chemical_list: D009211:Myoglobin; D013390:Succinylcholine; D011188:Potassium; D006221:Halothane
vernacular_title: Injektionsgeschwindigkeit von Succinylcholin und neuromuskulärer Wirkungseintritt, Serumkalium- bzw. -myoglobinkonzentration. Untersuchungen bei Männern in Halothannarkose.