title: Food effects on the nighttime pharmacokinetics of Theo-Dur tablets.
abstract: A randomized crossover study demonstrated major food effects on the pharmacokinetics of Theo-Dur, two 200-mg theophylline anhydrous sustained-release tablets, as an evening dose. These effects included a higher maximum serum theophylline level and relatively prolonged delay in drug absorption, both significant. The findings, which showed marked individual variation, could be clinically important for patients receiving evening medication.
authors.affiliation: Biodecison Laboratories, Inc., Pittsburgh, Pa 15206.
authors.forename: J
authors.initials: J
authors.lastname: Kann
authors.forename: M J
authors.initials: MJ
authors.lastname: Levitt
authors.forename: J W
authors.initials: JW
authors.lastname: Horodniak
authors.forename: J W
authors.initials: JW
authors.lastname: Pav
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D004435:Eating; D005502:Food; D006801:Humans; D008297:Male; D011897:Random Allocation; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D013806:Theophylline