c-myc oncogene product expression and prognosis in operable breast cancer.
The 62 kDa protein product of the c-myc oncogene (p62 c-myc) is thought to be involved in the control of normal cellular proliferation and differentiation. We have measured oncoprotein levels using a flow cytometric assay in 141 operable breast cancers and have correlated levels with prognostic variables, patient survival and disease free intervals. High levels of p62 c-myc were associated with well differentiated tumours. There was no correlation with tumour DNA index, lymph node or oestrogen receptor status. C-myc oncoprotein levels were not predictive of patient survival or disease free interval. This relationship of oncoprotein levels with tumour histological grade is in keeping with the suggestion that the c-myc oncogene is important in the control of cellular differentiation. The other findings imply that measurement of c-myc oncoprotein levels does not yield useful prognostic information.
Locker
A P
AP
Nottingham City Hospital, UK.
Dowle
C S
CS
Ellis
I O
IO
Elston
C W
CW
Blamey
R W
RW
Sikora
K
K
Evan
G
G
Robins
R A
RA
D001943:Breast Neoplasms / Q000032:analysis* / Q000235:genetics / Q000401:mortality; D006801:Humans; D008207:Lymphatic Metastasis; D011003:Ploidies; D011379:Prognosis; D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc; D011519:Proto-Oncogenes; D011960:Receptors, Estrogen / Q000032:analysis
D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc; D011960:Receptors, Estrogen