title: Improvement of tear lysosomal enzyme levels after treatment with bone marrow transplantation in a patient with I-cell disease.
abstract: We examined the lysosomal enzyme levels in tear fluids from a patient with I-cell disease after treatment by bone marrow transplantation. Acid phosphatase, beta-D-glucuronidase, N-acetyl-beta-D-glucosaminidase, alpha-L-fucosidase and alpha-D-mannosidase activities were reduced to normal or nearly normal levels after the treatment. We believe that the measurement of tear enzyme levels in I-cell disease is useful for knowing the efficacy of the bone marrow transplantation.
authors.affiliation: Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: S
authors.initials: S
authors.lastname: Hayasaka
authors.forename: S
authors.initials: S
authors.lastname: Hara
authors.forename: I
authors.initials: I
authors.lastname: Kurobane
authors.forename: K
authors.initials: K
authors.lastname: Tada
mesh_terms: D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D007223:Infant; D008247:Lysosomes / Q000201:enzymology*; D009081:Mucolipidoses / Q000201:enzymology* / Q000601:surgery; D013666:Tears / Q000201:enzymology*; D013997:Time Factors