Plant antimutagenic agents, 7. Structure and antimutagenic properties of cymobarbatol and 4-isocymobarbatol, new cymopols from green alga (Cymopolia barbata).
Two new compounds, cymobarbatol and 4-isocymobarbatol, were isolated from the marine alga Cymopolia barbata. The complete structures and absolute stereochemistries of these compounds were elucidated by a variety of spectroscopic techniques and X-ray crystallography. Both compounds were found to be nontoxic over a broad concentration range to Salmonella typhimurium strains T-98 and T-100. Both compounds exhibited strong inhibition of the mutagenicity of 2-aminoanthracene and ethyl methanesulfonate toward, respectively, the T-98 strain plus a metabolic activator and T-100.
Wall
M E
ME
Research Triangle Institute, Research Triangle Park, North Carolina 27709.
Wani
M C
MC
Manikumar
G
G
Taylor
H
H
Hughes
T J
TJ
Gaetano
K
K
Gerwick
H W
HW
McPhail
A T
AT
McPhail
D R
DR
D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology*; D000460:Chlorophyta / Q000032:analysis*; D008958:Models, Molecular; D015394:Molecular Structure; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects
D001578:Benzopyrans; C062201:cymobarbatol