title: Molecular phylogeny of the family of apes and humans.
abstract: The morphological picture of primate phylogeny has not unambiguously identified the nearest outgroup of Anthropoidea and has not resolved the branching pattern within Hominoidea. The molecular picture provides more resolution and clarifies the systematics of Hominoidea. Protein and DNA evidence divides Hominoidea into Hylobatidae (gibbons) and Hominidae, family Hominidae into Ponginae (orangutan) and Homininae, and subfamily Homininae into two tribes, one for Gorilla, and the other for Pan (chimpanzee) and Homo. Parsimony and maximum likelihood analyses, carried out on orthologous noncoding nucleotide sequences from primate beta-globin gene clusters, provide significant evidence for the human-chimpanzee tribe and overwhelming evidence for the human-chimpanzee-gorilla clade. These analyses also indicate that the rate of molecular evolution became slower in hominoids than in other primates and mammals.
authors.affiliation: Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201.
authors.forename: M
authors.initials: M
authors.lastname: Goodman
authors.forename: B F
authors.initials: BF
authors.lastname: Koop
authors.forename: J
authors.initials: J
authors.lastname: Czelusniak
authors.forename: D H
authors.initials: DH
authors.lastname: Fitch
authors.forename: D A
authors.initials: DA
authors.lastname: Tagle
authors.forename: J L
authors.initials: JL
authors.lastname: Slightom
mesh_terms: D000818:Animals; D001483:Base Sequence; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D010802:Phylogeny; D011506:Proteins / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
chemical_list: D011506:Proteins