Effect of antisecretory drugs on experimentally induced weanling diarrhoea in piglets.
In 45 newly-weaned 3 to 4-week-old piglets, diarrhoea was induced by a combined infection with transmissible gastroenteritis (TGE) virus and enterotoxigenic E. coli (ETEC) strains. In untreated control animals this dual inoculation resulted in profuse diarrhoea, vomiting, hypovolaemic shock and death of 77% of the animals within five days of TGE virus inoculation. Antisecretory drugs were administered intramuscularly for three consecutive days after experimental infection. The neurolepticum chlorpromazine, at 2 mg/kg/24 h, resulted in a significant inhibition of diarrhoea and vomiting, and in an increase in weight gain and survival. Sedation and hypothermia, however, were serious side-effects. The alpha 2 agonist clonidine, at 80 micrograms/kg/12 h, induced a significant antidiarrhoeal effect and a reduction in mortality. The drug, however, provoked decreased activity of alpha 2-adrenergic excitation and incoordination. The beta-adrenergic antagonist propranolol, at 0.33 mg/kg/8 h, and the calcium channel blocker verapamil, at 2 mg/kg/8 h, had no beneficial effect on the experimentally induced diarrhoea.
Cox
E
E
Laboratory of Veterinary Physiology, University of Antwerp, State University Centre, Belgium.
Cools
V
V
Houvenaghel
A
A
D000818:Animals; D000831:Animals, Newborn; D002746:Chlorpromazine / Q000627:therapeutic use; D003000:Clonidine / Q000627:therapeutic use; D003967:Diarrhea / Q000188:drug therapy / Q000662:veterinary*; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D005761:Gastroenteritis, Transmissible, of Swine / Q000188:drug therapy*; D011433:Propranolol / Q000627:therapeutic use; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy*; D014700:Verapamil / Q000627:therapeutic use
D011433:Propranolol; D014700:Verapamil; D003000:Clonidine; D002746:Chlorpromazine