title: [Lichen planus pemphigoides--report of a case and binding sites of circulating anti-basement membrane zone antibodies].
abstract: In this paper, we initially report a case which had clinical, histological and immuno-histochemical features consistent with the diagnosis of lichen planus pemphigoides (LPP). We then examined in vitro binding sites of circulating anti-basement membrane zone (BMZ) antibodies (Ab) from the patient using skin substrate separated through the lamina lucida by incubation in 1.0 M NaCl in order to study the localization of the LPP antigen. In indirect immunofluorescence examination, binding of anti-BMZ Ab from this patient was observed along the epidermal side of the separated skin in a linear pattern. When an indirect immunoelectron microscopy was performed on the separated skin, immune-reaction products were localized at basal cells from cytomembrane to hemidesmosomes in a massive and discontinuous fashion. These findings suggest that the binding sites of anti-BMZ Ab in LPP (localization of LPP antigen) are quite different from those of epidermolysis bullosa acquisita Ab, and show an intracellular association with hemidesmosomes in a fashion similar to those of bullous pemphigoid Ab.
authors.forename: Y
authors.initials: Y
authors.lastname: Song
authors.forename: K
authors.initials: K
authors.lastname: Naito
authors.forename: H
authors.initials: H
authors.lastname: Yaguchi
authors.forename: R
authors.initials: R
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Ikeda
authors.forename: S
authors.initials: S
authors.lastname: Morioka
authors.forename: H
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D001485:Basement Membrane / Q000276:immunology*; D001666:Binding Sites, Antibody; D002462:Cell Membrane / Q000276:immunology; D003896:Desmosomes / Q000276:immunology; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000276:immunology*; D008875:Middle Aged; D010391:Pemphigoid, Bullous / Q000276:immunology*; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology*
chemical_list: D001323:Autoantibodies