title: [Oral iron therapy. Bioavailability and therapeutic effectiveness of ferrous iron in effervescent tablets in posthemorrhagic iron deficiency anemia].
abstract: Bio-availability and therapeutic efficacy of two oral ferrous preparations in the form of effervescent tablets (A and A*) were compared. In a randomly controlled trial, postabsorption rise of serum iron was compared intraindividually after oral intake of the effervescent tablets and of an optimally bio-available ferrous ascorbate standard solution (80.5 mg). Afterwards the therapeutic efficacy of both preparations (161 mg daily) was compared with a proprietary iron preparation (B: 150 mg daily) for three months. The trial was conducted on 24 male subjects (aged 20-38 years) who underwent weekly phlebotomies of 500 ml until exhaustion of body iron reserves and development of a mild iron-deficiency anaemia (standard phlebotomy protocol). Relative bioavailability, related to the standard iron solution, was 89% and 104%, respectively, for tablets A and A*. The rise in haemoglobin and ferritin during the three-months treatment was relatively the same for all three preparations: the average daily haemoglobin rise (means +/- SD) was 1.4 +/- 0.5 g/l (A), 1.5 +/- 0.4 g/l (A*) and 1.2 +/- 0.5 g/l (B), respectively, the differences not being statistically significant.
authors.affiliation: Abteilung Hämatologie, Universität Frankfurt/Main.
authors.forename: J P
authors.initials: JP
authors.lastname: Kaltwasser
authors.forename: W
authors.initials: W
authors.lastname: Schwarz-van de Sand
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000747:Anemia, Hypochromic / Q000188:drug therapy* / Q000209:etiology; D001682:Biological Availability; D001815:Bloodletting; D002986:Clinical Trials as Topic; D005293:Ferritins / Q000097:blood; D005296:Ferrous Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006452:Hemoglobinometry; D006470:Hemorrhage / Q000150:complications; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D011897:Random Allocation; D013607:Tablets
chemical_list: D005296:Ferrous Compounds; D013607:Tablets; C020748:ferrous sulfate; D005293:Ferritins; D007501:Iron; C011819:ferrous gluconate
vernacular_title: Orale Eisentherapie. Bioverfügbarkeit und therapeutische Wirksamkeit von Ferro-Eisen als Brausetabletten bei posthämorrhagischer Eisenmangelanämie.