Circumventricular organs in chronic serum sickness: a model for cerebral lupus.
The pathogenesis of the CNS manifestations of systemic lupus erythematosus (SLE) has been the subject of considerable investigation. The focus of many of these studies has concerned immune complex deposition within the choroid plexus (CP). Involvement of the other brain fenestrated vascular beds, the small, paraventricular circumventricular organs, has not been ascertained. For this purpose, chronic serum sickness, a good immunopathological experimental model of naturally occurring systemic immunological disorders such as SLE, was induced in Wistar rats by prolonged immunization with bovine serum albumin (BSA). The involvement of circumventricular vascular beds by immune deposits was ascertained immunohistochemically. The choroid plexus was found to be the most intensely involved circumventricular structure. Immune complex deposits were also present, in descending order of frequency, in the area postrema, subfornical organ, and pineal gland.
Peress
N S
NS
Department of Pathology, VA Medical Center, Northport, NY.
Perillo
E
E
Fenstermacher
J D
JD
D000818:Animals; D001812:Blood-Brain Barrier; D001925:Brain Damage, Chronic / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology*; D002831:Choroid Plexus / Q000473:pathology; D003176:Complement C3 / Q000032:analysis*; D004195:Disease Models, Animal; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis*; D007678:Kidney Glomerulus / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000473:pathology*; D008297:Male; D019965:Neurocognitive Disorders / Q000473:pathology*; D010286:Paraventricular Hypothalamic Nucleus / Q000473:pathology*; D010870:Pineal Gland / Q000473:pathology; D010902:Pituitary Gland / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012710:Serum Albumin, Bovine / Q000032:analysis*; D012713:Serum Sickness / Q000473:pathology*; D013356:Subfornical Organ / Q000473:pathology
D003176:Complement C3; D007074:Immunoglobulin G; D012710:Serum Albumin, Bovine