Protein components of amyloid-like kidney stones of chronic hemodialysis patients.
We have examined amyloid-like kidney stones, commonly found in patients on maintenance hemodialysis. Extraction of protein from the stones and Western blot analysis were performed. beta 2-Microglobulin (beta 2MG), serum amyloid P component (SAP), lysozyme and PAS-positive substance were identified in the stones. It is suggested that calcium-mediated association of beta 2MG, lysozyme, SAP and PAS-positive substance may have an important role in the process of the formation of kidney stones in chronic hemodialysis patients.
Ozasa
H
H
Kidney Center, Tokyo Women's Medical College, Japan.
Suzuki
T
T
Takahashi
K
K
Ota
K
K
D000328:Adult; D015153:Blotting, Western; D005921:Glomerulonephritis / Q000628:therapy*; D006801:Humans; D007669:Kidney Calculi / Q000032:analysis* / Q000209:etiology; D008297:Male; D009113:Muramidase / Q000032:analysis; D010503:Periodic Acid-Schiff Reaction; D011506:Proteins / Q000032:analysis*; D006435:Renal Dialysis / Q000009:adverse effects*; D000683:Serum Amyloid P-Component / Q000032:analysis*; D001613:beta 2-Microglobulin / Q000032:analysis
D011506:Proteins; D000683:Serum Amyloid P-Component; D001613:beta 2-Microglobulin; D009113:Muramidase