title: Protection by recombinant human superoxide dismutase in lethal rat endotoxemia.
abstract: In summary as mechanism of the overall protective effect of r-HSOD in lethal rat endotoxemia, inhibition of hemoconcentration, a tendency of a decreased leukocyte activation and attenuation of consumption coagulopathy could be established.
authors.affiliation: Department of Pharmacology, Grünenthal GmbH, Aachen, FRGermany.
authors.forename: J
authors.initials: J
authors.lastname: Schneider
authors.forename: E
authors.initials: E
authors.lastname: Friderichs
authors.forename: H
authors.initials: H
authors.lastname: Giertz
mesh_terms: D000818:Animals; D004731:Endotoxins / Q000097:blood; D004926:Escherichia coli; D005340:Fibrinogen / Q000378:metabolism; D006400:Hematocrit; D006801:Humans; D007958:Leukocyte Count; D010976:Platelet Count; D051381:Rats; D011994:Recombinant Proteins; D018805:Sepsis / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D004731:Endotoxins; D011994:Recombinant Proteins; D005340:Fibrinogen; D013482:Superoxide Dismutase