Noncollagenous matrix proteins and their role in mineralization.
Improved technologies have led to the isolation of a large number of noncollagenous matrix proteins from the mineralized connective tissues. These proteins have been postulated to have many functions, but few of their suggested roles have been verified. Many of the noncollagenous matrix proteins are thought to regulate the deposition of hydroxyapatite mineral. In this review the current information on the role of these proteins in the mineralized and mineralizing connective tissues is presented along with a synopsis of the methods currently being used to elucidate these functions.
Boskey
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Laboratory for Ultrastructural Biochemistry, Hospital for Special Surgery, New York, NY 10021.
D000818:Animals; D005109:Extracellular Matrix / Q000032:analysis* / Q000502:physiology; D006801:Humans; D008903:Minerals / Q000378:metabolism*; D011506:Proteins / Q000032:analysis / Q000502:physiology*
D008903:Minerals; D011506:Proteins