[Clinical and pharmacokinetic study of ceftizoxime in newborn infants and children].
Ceftizoxime was evaluated in the treatment of 49 children and 15 neonates. The average dosage was 150 mg/kg/d for newborns and 115 mg/kg/d for children, administered IV, 3 or 4 times daily. Clinical and bacteriological cure was achieved in 93% children and 92% neonates. The clinical and biological tolerance was very good. Pharmacokinetic parameters were studied in 17 patients, including 2 neonates. In children the mean serum peak was 40 mug/ml and the mean half life was 2.2 +/- 0.6 H, after a dose of 30 mg/kg. In both neonates the half life was 3.1 H and 3.6 H. In urine, mean concentration of 4 g/l has been obtained in the first 2 hours after IV.
Bégué
P
P
Service Médecine Consultations, Hôpital Trousseau, Paris.
Baron
S
S
Borderon
J C
JC
Quinet
B
B
D000293:Adolescent; D001424:Bacterial Infections / Q000188:drug therapy*; D015296:Ceftizoxime / Q000493:pharmacokinetics / Q000627:therapeutic use* / Q000652:urine; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D006207:Half-Life; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015337:Multicenter Studies as Topic
D015296:Ceftizoxime
Etude clinique et pharmacocinétique du ceftizoxime chez le nouveau-né et l'enfant.