Interleukin 2 as an inducer of proliferation in Klebsiella-stimulated human B cells.
Klebsiella membranes (KLEBS M), a membrane preparation from Klebsiella pneumoniae, acts as a T-cell independent polyclonal B-cell activator (PBA), stimulating B cells to mature into Ig-secreting cells without prior proliferation. The KLEBS M-activated B cells express Tac antigen. Recombinant interleukin 2, used in costimulation with KLEBS M, induces proliferation and increases the Ig secretion of B cells. On the other hand, KLEBS M-activated B cells do not respond to human BCGF. The lack of proliferation in KLEBS M-stimulated mononuclear cells is shown to be due to the inability of this PBA to induce the production of interleukin 2 in T cells.
Stüber
F
F
I. Medizinische Universitätsklinik, Kiel, Federal Republic of Germany.
Ernst
M
M
Flad
H D
HD
Gross
W L
WL
D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D015847:Interleukin-4; D007378:Interleukins / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000276:immunology*; D008213:Lymphocyte Activation; D011994:Recombinant Proteins / Q000494:pharmacology; D012397:Rosette Formation
D007376:Interleukin-2; D007378:Interleukins; D011994:Recombinant Proteins; D015847:Interleukin-4