[Synthesis and physicochemical and biological characteristics of phthalazine derivatives].
Further studies in view of obtaining new stable phtalasiniuilides present the synthesis and physico-chemical and biological characterization of certain derivatives obtained through the action of p-phenyl-phenacyl and p-nitro-phenacyl bromides upon R-phtalasine. The structure of the new products was confirmed by physicochemical and spectral analyses. The preliminary biological tests showed a moderate antimicrobial activity of certain studies compounds.
Caproşu
M
M
Stefănescu
E
E
Petrovanu
M
M
Radu
C
C
D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008826:Microbial Sensitivity Tests; D010793:Phthalazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011724:Pyridazines / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D010793:Phthalazines; D011724:Pyridazines
Sinteza şi caracterizarea fizico-chimică şi biologică a unor derivaţi de ftalazină.