The barrier function of the outer membrane of Pseudomonas maltophilia in the diffusion of saccharides and beta-lactam antibiotics.
This paper reports that the efficiency of solute diffusion through the outer membrane of Pseudomonas maltophilia is roughly 3 to 5% of that of Escherichia coli. This is despite the fact that the outer membrane pore(s) is only a little smaller than that of E. coli. These results suggest that P. maltophilia has a low copy number of porin(s). The outer membrane of antibiotic resistant clinical isolates showed even less efficient permeability towards saccharides and antibiotics than the laboratory strains.
Yamazaki
E
E
Department of Cellular Information Sciences, Tokai University School of Medicine, Isehara, Japan.
Ishii
J
J
Sato
K
K
Nakae
T
T
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D002463:Cell Membrane Permeability; D004058:Diffusion; D004926:Escherichia coli / Q000378:metabolism; D007700:Kinetics; D011549:Pseudomonas / Q000378:metabolism* / Q000502:physiology; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams