title: Is the demonstration of bronchial hyperreactivity the sine qua non for diagnosing symptomatic bronchial asthma?
abstract: Bronchial hyperreactivity, a fundamental feature of bronchial asthma, is universally present in patients with symptomatic asthma. It can be reliably and safely demonstrated in the pulmonary function laboratory through pharmacological bronchoprovocation challenge testing. Furthermore, in the patient suspected of having symptomatic asthma, the laboratory determination of the presence of bronchial hyperreactivity is diagnostically of greater predictive value than findings on history, physical examination, routine spirometry, or the measurement of the total blood eosinophil count.
authors.affiliation: Division of Pulmonary Medicine, University of Massachusetts Medical School, Worcester 01605.
authors.forename: M R
authors.initials: MR
authors.lastname: Pratter
authors.forename: R S
authors.initials: RS
authors.lastname: Irwin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000175:diagnosis*; D001985:Bronchial Provocation Tests / Q000379:methods*; D001986:Bronchial Spasm / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds; D008875:Middle Aged; D011446:Prospective Studies; D012130:Respiratory Hypersensitivity / Q000175:diagnosis*; D012135:Respiratory Sounds / Q000209:etiology
chemical_list: D008688:Methacholine Compounds; D016210:Methacholine Chloride