[The small intestine in the presence of endotoxins in the blood. Effects of splenectomy].
We have studied the small intestine by morphologic and histochemical methods of mice treated with Serratia marcescens endotoxin (LD50); the half of the control and endotoxemic animals were splenectomized. We have not observed changes in the only splenectomized animals. We have found important alterations during the endotoxemia in the structure of small intestine, specially in the cells of the mucous membrane, as the cytoplasm and the nucleus. There are an increase of hemorrhagic phenomenons and of mucus, hemodynamic disturbances and loss of continuity of the intestinal wall. These changes are more notable in the endotoxemic and splenectomized animals than in the only endotoxemic animals. These results have be ratified by cytometric and statistic studies. The importance of the intestine in the endotoxemia and the function of the spleen are discussed.
López Muñiz
A
A
Díaz Fernández
C
C
Anitua Roldán
M J
MJ
Bengoechea
E
E
Pérez Casas
A
A
D000818:Animals; D004731:Endotoxins / Q000097:blood*; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D051379:Mice; D012706:Serratia marcescens; D013156:Splenectomy
D004731:Endotoxins
El intestino delgado durante la endotoxemia. Efectos de la esplenectomía.