title: The evolutionary conservation of eukaryotic gene transcription.
abstract: The basic components required for eukaryotic gene transcription have been highly conserved in evolution. Structural and functional homology has now been documented among promoters, promoter factors, regulatory proteins, and RNA polymerases from eukaryotes as diverse as yeast and mammals. The ability of these proteins and DNA sequences to function across phylogenetic boundaries demonstrates that common molecular mechanisms underlie gene control in all eukaryotic cells, and provides the basis for powerful new approaches to the study of eukaryotic gene transcription.
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0448.
authors.forename: M
authors.initials: M
authors.lastname: Schena
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002477:Cells / Q000378:metabolism*; D004247:DNA / Q000235:genetics; D004259:DNA-Directed DNA Polymerase; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics; D005786:Gene Expression Regulation; D011401:Promoter Regions, Genetic / Q000235:genetics; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D005656:Fungal Proteins; D014157:Transcription Factors; D004247:DNA; D012321:DNA-Directed RNA Polymerases; D004259:DNA-Directed DNA Polymerase