title: [Structure and properties of lipoteichoic acid of group A Streptococcus type M 29].
abstract: Lipoteichoic acid (LTA) of group A streptococci, type M 29 was studied. Chemical and 13C NMR spectroscopic analysis showed that the polymer contained poly(glycerophosphate) chain consisting of 12-14 glycerophosphate elements united by the 1----3 type phosphodiether bond and diglucosylglyceride. Oleic, stearic, palmitic and palmitoleic fatty acids predominated in the polymer composition. The content of the fatty acids amounted approximately to 2 per cent of LTA dry weight. The poly(glycerophosphate) chain contained 6-7 ether linked alanyl moieties. The results of the LTA biological study were analyzed in comparison to the data on a previous study of antitumor and cardiotoxic properties of teichoic acid from Streptomyces levoris K-3053 which is structurally close to the LTA hydrophilic moiety. It was assumed that the molecule negative charge had an effect on the cardiotoxic and antitumor activity.
authors.forename: E S
authors.initials: ES
authors.lastname: Vylegzhanina
authors.forename: N F
authors.initials: NF
authors.lastname: Dmitrieva
authors.forename: I B
authors.initials: IB
authors.lastname: Naumova
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Chekanova
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Epishin
authors.forename: T M
authors.initials: TM
authors.lastname: Oksman
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D002854:Chromatography, Paper; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism; D005994:Glycerophosphates / Q000032:analysis / Q000378:metabolism; D008070:Lipopolysaccharides / Q000032:analysis* / Q000302:isolation & purification / Q000378:metabolism; D008968:Molecular Conformation; D013297:Streptococcus pyogenes / Q000378:metabolism*; D013682:Teichoic Acids / Q000302:isolation & purification / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D005994:Glycerophosphates; D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid
vernacular_title: Stroenie i svoĭstva lipoteĭkhoevoĭ kisloty streptokokka gruppy A tipa M 29.