Transient cyclic neutropenia following GM-CSF in a patient with chronic granulocytic leukemia transplanted with HLA-identical T cell-depleted donor bone marrow.
Treatment with GM-CSF or G-CSF is becoming widely used in patients with chronic neutropenia, or who are aplastic following chemotherapy or autologous or allogeneic bone marrow transplantation. Recently, some authors have described a phenomenon analogous to cyclic agranulocytosis following treatment with G-CSF in a patient with chronic neutropenia. We wish to describe the same phenomenon in a patient with chronic granulocytic leukemia who received GM-CSF (Sandoz) after T cell depletion in order to accelerate hematological reconstitution.
Gluckman
E
E
Bone Marrow Transplant Unit, Hôpital Saint Louis, Paris, France.
Socie
G
G
Yver
A
A
Esperou
H
H
Devergie
A
A
Stern
A
A
D000380:Agranulocytosis / Q000209:etiology*; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000473:pathology; D003115:Colony-Stimulating Factors / Q000009:adverse effects*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000009:adverse effects*; D006680:HLA Antigens; D006801:Humans; D015466:Leukemia, Myeloid, Chronic-Phase / Q000276:immunology / Q000601:surgery* / Q000628:therapy; D007958:Leukocyte Count; D008212:Lymphocyte Depletion; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood / Q000209:etiology* / Q000473:pathology; D010507:Periodicity; D013601:T-Lymphocytes
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D006680:HLA Antigens; D016178:Granulocyte-Macrophage Colony-Stimulating Factor