title: [The significance and treatment of late distant metastasis in breast cancer].
abstract: More than half of the patients relapsing with breast cancer will do so after 3 years. Disease free survival is negatively influenced by tumor size and increasing numbers of positive axillary lymph nodes. Small primaries, negative nodes and positive estrogen receptors predict long overall survival. Many additional prognostic factors exist, however, they are not yet in general use. Similarly to early relapses, patients with late relapses do better with skeletal than with visceral metastases. Women with liver metastases should therefore be treated with chemotherapy, whereas bone disease may respond for prolonged periods to hormonal manipulation.
authors.forename: R
authors.initials: R
authors.lastname: Obrist
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D011379:Prognosis
vernacular_title: Bedeutung und Behandlung spät auftretender Fernmetastasen beim Mammakarzinom.