title: [Carbohydrate tolerance and the blood levels of insulin and cortisol in the nonnative population of Chukotia].
abstract: Changes in endocrine-metabolic interrelationships (changes in blood hormone levels, the level of glycemia and carbohydrate tolerance) can be observed in a person moving to high altitude areas. The purpose of the present study was to investigate glucose tolerance disorders (GTD) in Chukot migrants and to examine the relationships of GTD development with blood insulin and cortisol levels. A representative sampling of male population aged 30 to 59 was examined. Carbohydrate metabolism was estimated using the GTT. Blood hormone levels were determined by a radioimmunoassay. Various types of GTD were revealed in 16% of the examinees. In persons with GTD total insulinemia after carbohydrate tolerance testing was higher than that in the examinees without GTD. GTD frequency was unassociated with basal insulinemia. Blood cortisol levels in the examenees with GTD were higher then those in the examinees without GTD. GTD frequency was higher in the examinees with the level of cortisol over 220 ng/ml. A conclusion is that a high frequency of GTD in Chukot migrants is associated, to a great extent, with an increased level of blood cortisol in relative insulin insufficiency.
authors.forename: E G
authors.initials: EG
authors.lastname: Stepanova
authors.forename: V P
authors.initials: VP
authors.lastname: Babin
authors.forename: E O
authors.initials: EO
authors.lastname: Stepkina
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D005215:Fasting; D005951:Glucose Tolerance Test; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012800:Siberia; D013997:Time Factors; D014171:Transients and Migrants
chemical_list: D001786:Blood Glucose; D007328:Insulin; D006854:Hydrocortisone
vernacular_title: Tolerantnost' k uglevodam i uroven' insulina i kortizola v krovi u prishlogo naseleniia Chukotki.