title: Stereotactic radiosurgery for intracranial arteriovenous malformations using a standard linear accelerator.
abstract: We have previously described the development of a technique which utilizes a standard linear accelerator to provide stereotactic, limited field radiation. The radiation is delivered using a modified and carefully calibrated 6 MV linear accelerator. Precise target localization and patient immobilization is achieved using a Brown-Roberts-Wells (BRW) stereotactic head frame which is in place during angiography, CT scanning, and treatment. Seventeen arteriovenous malformations (AVMs) have been treated in 16 patients from February 1986 to July 1988. Single doses of 1500-2500 cGy were delivered using multiple non-coplanar arcs with small, sharp edged x-ray beams to lesions less than 2.7 cm in greatest diameter. The dose distribution from this technique has a very rapid dropoff of dose beyond the target volume. Doses were prescribed at the periphery of the AVMs, typically to the 80-90% isodose line. Eleven of 16 patients have been followed by repeat angiography at least 1 year following treatment. Five of 11 have had complete obliteration of their AVM in 1 year and an additional three patients have achieved complete obliteration by 24 months. There have been no incidences of rebleeding or serious complications in any patient. We conclude that stereotactic radiosurgery using a standard linear accelerator is an effective and safe technique in the treatment of intracranial AVMs and the results compare favorably to the more expensive and elaborate systems that are currently available for stereotactic treatments.
authors.affiliation: Department of Radiation Therapy, Harvard Medical School, Boston, MA 02115.
authors.forename: J S
authors.initials: JS
authors.lastname: Loeffler
authors.forename: E
authors.initials: E
authors.lastname: Alexander
authors.forename: R L
authors.initials: RL
authors.lastname: Siddon
authors.forename: W M
authors.initials: WM
authors.lastname: Saunders
authors.forename: C N
authors.initials: CN
authors.lastname: Coleman
authors.forename: K R
authors.initials: KR
authors.lastname: Winston
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000532:radiotherapy*; D008875:Middle Aged; D010315:Particle Accelerators; D013238:Stereotaxic Techniques