The B subunit of coagulation factor XIII is linked to renin and the Duffy blood group to alpha-spectrin on human chromosome 1.
Family linkage studies were used to detect two linkage relationships on human chromosome 1. The B subunit of coagulation factor XIII showed significant linkage to renin with a maximum lod score of 5.071 at a distance of 10 cM. Significant linkage was also shown between the Duffy blood group and alpha-spectrin with linkage results giving a combined lod score of 3.194 at 5 cM.
Griffiths
L R
LR
Department of Medicine, University of Sydney, Australia.
Board
P G
PG
Zwi
M B
MB
Morris
B J
BJ
McLeod
J G
JG
Nicholson
G A
GA
D001789:Blood Group Antigens / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004375:Duffy Blood-Group System / Q000235:genetics*; D005176:Factor XIII / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D011995:Recombination, Genetic; D012083:Renin / Q000235:genetics*; D013049:Spectrin / Q000235:genetics*
D001789:Blood Group Antigens; D004375:Duffy Blood-Group System; D005819:Genetic Markers; D013049:Spectrin; D005176:Factor XIII; D012083:Renin