The effect of cyclosporin A on the endocrine pancreas of rats.
Treatment with the immunosuppressive agent Cyclosporin A frequently gives rise to alteration of function in the Langerhans islet which may result in diabetes. Light microscopy, immunocytochemical, and electron microscopic investigations demonstrate degranulation and vacuolization of B endocrine pancreatic cells in treated animals. Similar changes, but to a milder degree, are observed in the A-cells. The morphological alterations described are likely to result from an inhibition of the synthesis and secretion of B-cells.
Jablenska
R
R
Department of Anatomy and Histology, Medical Academy, Sofia, Bulgaria.
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology*; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D007328:Insulin