title: The muscle in fibromyalgia--a review of Swedish studies.
abstract: In Sweden, several studies have been performed in patients with fibromyalgia to study muscle morphology, chemistry and physiology in order to understand the origin of the most prominent symptoms in fibromyalgia: muscle pain, muscle fatigue and muscle stiffness. These studies have shown changes indicating disturbed microcirculation, mitochondrial damage and a reduced content of high energy phosphates. Thus, there may be an energy deficiency state in the resting painful muscle in fibromyalgia. Pain analysis has supported the idea that there is a nociceptive origin of the pain. Our hypothesis is that any condition that could lead to constant muscle hypoxia, e.g., through establishment of abnormal motor patterns, might be a possible cause of fibromyalgic pain.
authors.affiliation: Department of Internal Medicine, University Hospital, Linköping, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Bengtsson
authors.forename: K G
authors.initials: KG
authors.lastname: Henriksson
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001706:Biopsy; D003238:Connective Tissue / Q000473:pathology; D005356:Fibromyalgia / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008833:Microcirculation; D008954:Models, Biological; D009132:Muscles / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D010146:Pain; D010147:Pain Measurement; D010725:Phosphocreatine / Q000378:metabolism
chemical_list: D010725:Phosphocreatine; D000255:Adenosine Triphosphate