Studies on antifungal agents. 20. Effect of the nitrogen substitution on the in vitro activity of novel 3,5-substituted isoxazolidines.
The effect of the nitrogen substitution on the in vitro antifungal activity of a series of novel cis-3,5-substituted isoxazolidine derivatives is investigated. The 2-(N-methyl) analogues 4-6 were found to be the most active compounds when tested in vitro against Trichophyton rubrum, Aspergillus fumigatus and Candida albicans, with MIC values ranging between 0.7 and 70 micrograms/ml.
Swift
P A
PA
Department of Organic Chemistry, Pennwalt Corporation, Rochester, N.Y.
Mullen
G B
GB
Mitchell
J T
JT
Allen
S D
SD
St Georgiev
V
V
D000935:Antifungal Agents; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007555:Isoxazoles / Q000494:pharmacology*; D009584:Nitrogen; D010080:Oxazoles / Q000494:pharmacology*; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D007555:Isoxazoles; D010080:Oxazoles; D009584:Nitrogen