Cytosolic ferritin and lipid-associated ferritin are metabolically different in guinea-pig livers.
A distinct pool of liver ferritin has been described in man, guinea pigs and rats [Cham, Roeser, Nikles & Ridgway (1986) Clin. Chim. Acta 158, 71-79]. This ferritin accounts for approx. 30% of total intracellular ferritin. It differs from previously described cytosolic and 'microsomal-fraction' ferritin by its firm association with lipid and by the absence of heat-stability at 75 degrees C. The present study demonstrates that cytosolic ferritin and lipid-associated ferritin in guinea-pig livers have distinctly different rates of turnover. Cytosolic ferritin has a rate of turnover approx. 3.5 times as high as lipid-associated ferritin. The apparent metabolic heterogeneity suggests that the two forms of ferritin may have different functional roles.
Cham
B E
BE
Department of Medicine, University of Queensland, Royal Brisbane Hospital, Australia.
Roeser
H P
HP
Nikles
A C
AC
D000818:Animals; D002451:Cell Compartmentation; D003600:Cytosol / Q000378:metabolism; D005293:Ferritins / Q000276:immunology / Q000378:metabolism*; D006168:Guinea Pigs; D007158:Immunologic Techniques; D007700:Kinetics; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male
D005293:Ferritins