Autoregulation of interleukin 6 and granulocyte-macrophage colony-stimulating factor in the differentiation of myeloid leukemic cells.
Induction of differentiation in one type of clone of mouse myeloid leukemic cells by mouse or human interleukin 6 (IL-6) and in another type of clone by mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) was found to be associated with induction of IL-6 and GM-CSF mRNA and protein. The results indicated that IL-6 and GM-CSF could positively autoregulate their own gene expression during myeloid cell differentiation. It is suggested that this autoregulation may serve to enhance and prolong the signal induced by these proteins in cells transiently exposed to IL-6 or GM-CSF.
Shabo
Y
Y
Department of Genetics, Weizmann Institute of Science, Rehovot, Israel.
Lotem
J
J
Sachs
L
L
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000235:genetics*; D005786:Gene Expression Regulation; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000235:genetics*; D006706:Homeostasis; D006801:Humans; D015850:Interleukin-6; D007378:Interleukins / Q000235:genetics* / Q000494:pharmacology; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D051379:Mice; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D015850:Interleukin-6; D007378:Interleukins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor