Plasma renin activity and aldosterone: correlations with moderate hypohydration.
Adult male test subjects (n = 16) were assigned to one of three clothing configurations (Army fatigues, fatigues with impermeable chemical protective garments, and fatigues with protective garments plus protective masks) prior to exercise (level treadmill, 1.11 m/s, 50 min/h, 6 h) in a moderate (wet bulb globe temperature, WBGT = 23 degrees C) environment with ad lib water consumption. When protective masks were worn, two through-mask drinking systems were evaluated: the current gravity-fed system for fluid delivery and a new system utilizing a small hydraulic pump (Fist-Flex). Antecubital blood samples were taken prior to the start of and subsequent to the completion of exercise and analyzed for fluid-electrolyte regulatory hormones. During all trials with chemical protective garments, plasma renin activity (PRA) and aldosterone levels (PA) were significantly (p less than 0.05) elevated following the exercise protocol while neither was affected during exercise in fatigues only. Individual hypohydration levels during all trials ranged from low (0.84%) to moderate (4.04%). Levels of PRA were closely correlated (r = 0.635, t = 4.35, p less than 0.001) with hypohydration as measured by percentage of body weight lost during the 6 h trial. Likewise, PA was also correlated (r = 0.47, t = 2.81, p less than 0.01) with body weight loss. We concluded from this study that PRA and PA responses were exacerbated in moderate environments by the additional heat stress, sweat rate, and dehydration caused by the impermeable garments. Further, the logistical difficulty inherent in delivering fluid through the chemical protective mask reduced voluntary consumption, increased hypohydration, and elicited the greatest elevations in PRA and PA.(ABSTRACT TRUNCATED AT 250 WORDS)
Francesconi
R P
RP
Heat Research Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760-5007.
Szlyk
P C
PC
Sils
I V
IV
Leva
N
N
Hubbard
R W
RW
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D003681:Dehydration / Q000097:blood*; D015444:Exercise / Q000502:physiology; D006359:Heat Exhaustion / Q000097:blood*; D006801:Humans; D008297:Male; D011481:Protective Clothing / Q000009:adverse effects; D012083:Renin / Q000097:blood*; D014882:Water-Electrolyte Balance / Q000502:physiology
D000450:Aldosterone; D012083:Renin