title: Amyloid plaques, neurofibrillary tangles and their relevance for the study of Alzheimer's disease.
abstract: The relevance of plaques and tangles to the study of Alzheimer's disease is considered. Recent results concerning isoforms of microtubule-associated protein tau, their expression and incorporation into paired helical filaments, are discussed.
authors.affiliation: Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.
authors.forename: M
authors.initials: M
authors.lastname: Goedert
authors.forename: R A
authors.initials: RA
authors.lastname: Crowther
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000682:Amyloid / Q000378:metabolism*; D016229:Amyloid beta-Peptides; D006801:Humans; D009454:Neurofibrils / Q000378:metabolism* / Q000473:pathology
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides