Pharmacologic perturbation strategies in the study of the neurobiology of depression.
1. Psychological, behavioral, physiological, biochemical, and receptor binding measurements are useful as dependent variables when studying the biology of depression and mania. 2. Pharmacological perturbations of cholinergic mechanisms can produce changes mimicking aspects of the neurobiology of affective disorders. 3. These changes can be quantitated by measuring their impact on variables in each of these classes. 4. Pharmacological methods for inducing these changes in cholinergic systems and their application to clinical and basic research in the field of affective disorders are highlighted.
Dilsaver
S C
SC
Department of Psychiatry, Ohio State University, Columbus.
D000818:Animals; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D010275:Parasympathetic Nervous System / Q000187:drug effects