title: [Ionized calcium, total calcium and albumin corrected calcium in the serum in 1213 patients with suspected calcium metabolic diseases. A prospective multicenter study].
abstract: The correlation between serum ionized calcium, serum total calcium and albumin corrected total calcium was investigated in a prospective multicentre investigation of 1,213 patients with suspected calcium metabolic disease. 31.0% of the patients were misclassified when serum total calcium was measured instead of serum ionized calcium. The diagnostic discrepancy between the two methods decreased with the calculation of albumin corrected total calcium or calculated ionized calcium (17.9%). On justing for the analytical error connected with the measurement of ionized calcium, 11.2% of the patients were still misclassified. It is not possible precisely to predict serum ionized calcium from the measurement of serum total calcium and we recommend measurement of serum ionized calcium in patients believed to have calcium metabolic disease.
authors.forename: J
authors.initials: J
authors.lastname: Thode
authors.forename: B
authors.initials: B
authors.lastname: Juul-Jørgensen
authors.forename: H M
authors.initials: HM
authors.lastname: Bhatia
authors.forename: M
authors.initials: M
authors.lastname: Kjaerulf-Nielsen
authors.forename: P D
authors.initials: PD
authors.lastname: Bartels
authors.forename: N
authors.initials: N
authors.lastname: Fogh-Andersen
authors.forename: O
authors.initials: O
authors.lastname: Siggaard-Andersen
mesh_terms: D002118:Calcium / Q000097:blood*; D002128:Calcium Metabolism Disorders / Q000097:blood*; D003718:Denmark; D006801:Humans; D015337:Multicenter Studies as Topic; D011446:Prospective Studies; D012709:Serum Albumin / Q000032:analysis
chemical_list: D012709:Serum Albumin; D002118:Calcium
vernacular_title: Ioniseret calcium, totalcalcium og albumin-korrigeret calcium i serum hos 1.213 patienter mistaenkt for calciummetabolisk sygdom. En prospektiv multicenterundersøgelse.