title: Platinum disposition after intraarterial and intravenous infusion of cisplatin for osteosarcoma. Cooperative Osteosarcoma Study Group COSS.
abstract: Preoperative chemotherapy according to the COSS 86 protocol, including two courses of cisplatin, was used for high-risk osteosarcoma. Patients were randomised to receive either intraarterial (i.a.) or intravenous (i.v.) cisplatin infusions. As measured by flameless atomic absorption spectroscopy (FAAS), platinum (Pt) levels in serum, ultrafiltrate, and urine did not show a decrease in systemic drug availability with i.a. administration. Tumors were surgically removed 3 weeks after the last cisplatin dose and analysed for Pt content and response to chemotherapy. A correlation could not be demonstrated between Pt levels in tumor tissue samples and the mode of CDDP application or extent of tumor cell destruction.
authors.affiliation: Abteilung für pädiatrische Hämatologie und Onkologie, Universitäts-Kinderklinik Hamburg-Eppendorf, Federal Republic of Germany.
authors.forename: S S
authors.initials: SS
authors.lastname: Bielack
authors.forename: R
authors.initials: R
authors.lastname: Erttmann
authors.forename: G
authors.initials: G
authors.lastname: Looft
authors.forename: C
authors.initials: C
authors.lastname: Purfürst
authors.forename: G
authors.initials: G
authors.lastname: Delling
authors.forename: K
authors.initials: K
authors.lastname: Winkler
authors.forename: G
authors.initials: G
authors.lastname: Landbeck
mesh_terms: D001859:Bone Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D015337:Multicenter Studies as Topic; D012516:Osteosarcoma / Q000188:drug therapy* / Q000378:metabolism; D010984:Platinum / Q000493:pharmacokinetics
chemical_list: D010984:Platinum; D002945:Cisplatin