High levels of the c-myc protein in cell lines of Bloom's syndrome origin.
Lymphoblastoid cell lines derived from cancer prone Bloom's Syndrome patients differ from cell lines representative of several other disorders by exhibiting a constitutive elevation in the level of the c-myc protein. This may be a contributing factor in the strong predisposition to malignancy observed in Bloom's syndrome.
Sullivan
N F
NF
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hert, U.K.
Willis
A E
AE
Moore
J P
JP
Lindahl
T
T
D001816:Bloom Syndrome / Q000201:enzymology / Q000235:genetics*; D002460:Cell Line; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D011505:Protein-Tyrosine Kinases / Q000032:analysis*; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D016271:Proto-Oncogene Proteins c-myc; D011519:Proto-Oncogenes
D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc; D011505:Protein-Tyrosine Kinases