title: [Clonidine versus a placebo trial in manic disorder].
abstract: Clonidine efficacy was evaluated in 24 manic inpatients, hospitalised in a locked ward. This is a double blind and randomized study. The duration of the trial was 14 days, and the daily dose of clonidine was 0.225 mg/day during the first week, increased to 0.450 mg/day during the second week, in the case of incomplete improvement. There was a trend for a better efficacy of clonidine over placebo, but this did not reach significant, due to an important amelioration of many patients under placebo. The effects of the hospitalisation in a locked ward are discussed.
authors.affiliation: Travail du Service du Pr D. Widlöcher, U 302, Hôpital de la Salpêtrière, Paris.
authors.forename: M C
authors.initials: MC
authors.lastname: Hardy-Bayle
authors.forename: Y
authors.initials: Y
authors.lastname: Lecrubier
authors.forename: S
authors.initials: S
authors.lastname: Lancrenon
authors.forename: J
authors.initials: J
authors.lastname: Laine
authors.forename: J F
authors.initials: JF
authors.lastname: Allilaire
authors.forename: A
authors.initials: A
authors.lastname: Des Lauriers
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy*; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors
chemical_list: D003000:Clonidine
vernacular_title: Essai "clonidine contre placebo" dans la manie.