Cellular basis and oncogene expression of rheumatoid joint destruction.
A new animal model for human rheumatoid arthritis is described, and the unsolved questions regarding the mechanism of primary joint destruction are discussed. Following an analysis of the types of cells and antibodies found in joints affected by rheumatoid arthritis, it is concluded that both expression of oncogenes and the presence of retroviral sequences detectable by monoclonal antibodies to HTLV I p19 and p24 sequences are associated with early abnormal proliferation of apparently transformed cells at the site of initial cartilage and/or bone destruction.
Gay
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Department of Medicine, University of Alabama, Birmingham 35294.
Gay
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D000818:Animals; D001168:Arthritis / Q000473:pathology*; D001169:Arthritis, Experimental / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D001323:Autoantibodies / Q000032:analysis; D002358:Cartilage, Articular / Q000276:immunology / Q000648:ultrastructure*; D002455:Cell Division; D003094:Collagen / Q000276:immunology; D003713:Dendritic Cells / Q000648:ultrastructure; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D015689:Oncogene Protein p21(ras) / Q000032:analysis; D016274:Oncogene Protein p55(v-myc); D011505:Protein-Tyrosine Kinases / Q000032:analysis; D015682:Retroviridae Proteins, Oncogenic / Q000032:analysis; D013583:Synovial Membrane / Q000166:cytology / Q000276:immunology / Q000648:ultrastructure*
D001323:Autoantibodies; D016274:Oncogene Protein p55(v-myc); D015682:Retroviridae Proteins, Oncogenic; D003094:Collagen; D011505:Protein-Tyrosine Kinases; D015689:Oncogene Protein p21(ras)