[Possible protective role of calcium inhibitors in drug nephrotoxicity].
Many experimental studies have shown that calcium channel blockers could prevent drug-induced acute renal failure. In dog, nifedipine and verapamil prevent decreasing blood flow produced by contrast material. In rat, administration of verapamil has beneficial effects on gentamycin nephrotoxicity. Verapamil improves renal function in rats with acute renal failure due to cyclosporine. Calcium channel blockers have various effects on cisplatinum nephrotoxicity: in rat, nifedipine worsens nephrotoxicity; in man, verapamil prevents nephrotoxicity due to cisplatinum. In addition, nifedipine seems to improve renal function in transplanted patients treated with cyclosporine. In 2 control studies, we did not find any effect of diltiazem on prevention of renal toxicity due to methotrexate and cisplatinum. Calcium channel blockers could prevent nephrotoxicity by reducing calcium transfer across cell membranes and/or inhibiting the action of vasoconstrictive hormones.
Deray
G
G
Dubois
M
M
Martinez
F
F
Baumelou
A
A
Jacobs
C
C
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control
D002121:Calcium Channel Blockers
Rôle protecteur éventuel des inhibiteurs calciques sur la néphrotoxicité médicamenteuse.