[The role of free fatty acids in the pathogenesis of arteriosclerosis].
Several diseases and functional disturbances (e.g. diabetes mellitus, obesity, phaeochromocytoma, chronic renal functional disturbances, psychosocial stress) marked by a disturbed metabolism of free fatty acids (FFA) and a hyperlipacidaemia correlate with a premature occurrence of arteriosclerotic alterations of the vessels. The FFA do not play an unimportant role as a link in the causal chain between the above-mentioned diseases or functional disturbances on the one hand and the atherogenesis on the other. Therefore an overview is given of the influence of a hyperlipacidaemia on important partial processes of the atherogenesis. In this connection the role of FFA in the lesion of the endothelium and in the formation of foam cells is depicted.
Kuhfahl
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Abteilung Klinische Laboratorien, Bezirkskrankenhauses Dresden-Neustadt.
D001161:Arteriosclerosis / Q000473:pathology*; D004730:Endothelium, Vascular / Q000473:pathology*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006801:Humans; D012307:Risk Factors
D005230:Fatty Acids, Nonesterified
Die Rolle der freien Fettsäuren in der Pathogenese der Arteriosklerose.