[Felodipine in arterial hypertension. Double-blind comparison with atenolol].
Felodipine is a new dihydropyridine calcium antagonist which selectively relaxes vascular smooth muscle. It lovers dose-dependently blood pressure in hypertensives patients. In this multicentre double-blind study, 113 patients (mean age 50 +/- 14 years) whose diastolic blood pressure was higher than 95 mmHg after withdrawal of an eventual antihypertensive therapy and a week of placebo administration. The patients received randomly either felodipine (5 mg x 2/j during two weeks and then 10 mg x 2/day) either atenolol (100 mg/day) during two months. Antihypertensive effects of these two drug regimens were not significantly different. Supine blood pressure decreased from 177 +/- 22/107 +/- 8 mmHg to 152 +/- 27/91 +/- 13 mmHg with felodipine and from 176 +/- 19/107 +/- 8 to 152 +/- 24/91 +/- 12 with atenolol. Side effects recorded by means of active questioning were ankle oedemas and headache with felodipine and fatigue and headache with atenolol.
Andrejak
M
M
Witchitz
S
S
Morand
P
P
Lesbre
J P
JP
Raveau-Landon
C
C
D000328:Adult; D000368:Aged; D001262:Atenolol / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004311:Double-Blind Method; D015736:Felodipine; D005260:Female; D005602:France; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009568:Nitrendipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011897:Random Allocation
D002121:Calcium Channel Blockers; D001262:Atenolol; D009568:Nitrendipine; D015736:Felodipine
La félodipine dans l'hypertension artérielle. Comparaison en double aveugle avec l'aténolol.