title: Use of phenytoin in healing of war and non-war wounds. A pilot study of 25 cases.
abstract: Nineteen patients with war-related missile wounds and six with refractory civilian ulcers were treated with topical phenytoin sodium powder daily for up to 4 weeks. The mean healing time was 2 weeks for missile wounds, compared to historical controls requiring 6-8 weeks. Healing time was 4 weeks for civilian ulcers that had been unresponsive to any treatment over the previous 5 months. Twenty-two patients had complete healing, three required skin grafts. Wider use of this safe, inexpensive, readily available and easy-to-use agent is suggested because of its positive effect on wound healing and rapid pain relief.
authors.affiliation: Department of Orthopedic Surgery, Shahid Rahnomoon Hospital, University of Medical Science of Iran, Tehran.
authors.forename: S
authors.initials: S
authors.lastname: Modaghegh
authors.forename: B
authors.initials: B
authors.lastname: Salehian
authors.forename: M
authors.initials: M
authors.lastname: Tavassoli
authors.forename: A
authors.initials: A
authors.lastname: Djamshidi
authors.forename: A S
authors.initials: AS
authors.lastname: Rezai
mesh_terms: D002986:Clinical Trials as Topic; D006097:Granulation Tissue / Q000473:pathology; D006801:Humans; D010672:Phenytoin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010865:Pilot Projects; D012883:Skin Ulcer / Q000188:drug therapy*; D014857:Warfare; D014945:Wound Healing; D014947:Wounds and Injuries / Q000188:drug therapy*
chemical_list: D010672:Phenytoin