Isoproterenol-induced facilitation of norepinephrine release does not primarily involve a local angiotensin II mechanism in guinea pig pulmonary arteries.
We have attempted to clarify whether or not captopril and 1Sar-8Ile-angiotensin II could protect isoproterenol-induced facilitation of norepinephrine release in guinea pig pulmonary arteries loaded with 3H-norepinephrine. Angiotensin I at 1 nM and 30 nM isoproterenol similarly facilitated evoked release of 3H-norepinephrine at 1 Hz. Captopril at 1 microM and 1Sar-8Ile-angiotensin II at 10 nM completely prevented angiotensin I-induced facilitation, whereas these pretreatments produced no effect on isoproterenol-induced facilitation. Isoproterenol-induced facilitation of norepinephrine release does not primarily involve a local angiotensin II mechanism.
Kuwahara
M
M
Department of Pharmacology, Yokohama City University School of Medicine, Japan.
Kubo
T
T
Misu
Y
Y
D015059:1-Sarcosine-8-Isoleucine Angiotensin II / Q000494:pharmacology; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D002216:Captopril / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism*; D011651:Pulmonary Artery / Q000187:drug effects / Q000378:metabolism / Q000502:physiology
D000804:Angiotensin II; D015059:1-Sarcosine-8-Isoleucine Angiotensin II; D002216:Captopril; D007545:Isoproterenol; D009638:Norepinephrine