Splenopentin--influence on antibody formation in immunosuppressed animals and on phagocytic capability of human granulocytes.
Sublethally x-ray irradiated C57 Bl/6 Bln. mice (whole body irradiation with 600 cGy) were treated with or without a splenopentin derivative (DA SP-5: N alpha-acetyl-L-arginyl)-(N alpha-acetyl-L-lysyl)-L-glutamyl-L-valyl-L-tyrosine and compared for their capacity to produce antibodies against target sheep red blood cells. As demonstrated DA SP-5 treated mice produced antibodies earlier and in a higher level than animals untreated. Furthermore, DA SP-5 influences the phagocytic capability of human granulocytes in a dose dependent matter.
Diezel
W
W
Department of Dermatology, Medical School (Charité), Humboldt University, Berlin.
Eckert
R
R
Müller
G M
GM
Forner
K
K
Sönnichsen
N
N
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D007109:Immunity / Q000187:drug effects / Q000528:radiation effects*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*; D013946:Thymopoietins / Q000138:chemical synthesis / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; C060485:berlopentin