[Kaposi's sarcoma after kidney transplantation].
A Kaposi's sarcoma of the skin with nodular and follicular lesions but no visceral involvement developed in a 44-year-old man nine months after transplantation of an haplo-identical kidney (a relative as donor). He was on an immunosuppressive regimen of daily 10 mg methylprednisolone and 2.5 mg/kg cyclosporin A. No HIV antibodies were demonstrated. After reduction of the dosage to 4 mg methylprednisolone and 1 mg/kg cyclosporin A no further growth of the skin lesions was observed, while transplant function was maintained. The lesions regressed after radiation of two areas in the right lower leg with 48 Gy. Ten months later the sarcoma again progressed and required further radiotherapy, which arrested growth, while there was no change in transplant function.
Heering
P
P
Abteilung für Nephrologie, Medizinische Universitätsklinik und Poliklinik, Düsseldorf.
Meschig
R
R
Glück
S
S
Kreusser
W
W
Plewig
G
G
Grabensee
B
B
D000328:Adult; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000532:radiotherapy; D012074:Remission Induction; D012514:Sarcoma, Kaposi / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000532:radiotherapy; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000532:radiotherapy; D013997:Time Factors
D003524:Cyclosporins; D008727:Methotrexate
Kaposi-Sarkom nach Nierentransplantation.