title: Adverse effects of a proposed equine sublethal endotoxin model.
abstract: Commercially available Escherichia coli 055: B5 lipopolysaccharide was administered intravenously experimentally at a dosage of 10 micrograms/kg to 2 horses. Various clinical and clinico-pathological parameters were monitored before and after the endotoxin administration. Because of a hopeless prognosis, and for humane reasons, euthanasia was applied on both horses 6 h after administration. Values recorded for the different parameters, including the blood lactate level, were consistent with a lethal condition. It would appear that an intravenous dose of 10 micrograms/kg of endotoxin is potentially lethal to horses.
authors.affiliation: Department of Medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort.
authors.forename: P
authors.initials: P
authors.lastname: Stadler
authors.forename: S R
authors.initials: SR
authors.lastname: Van Amstel
mesh_terms: D000818:Animals; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D005260:Female; D006734:Horse Diseases / Q000097:blood* / Q000473:pathology; D006736:Horses; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male
chemical_list: D004731:Endotoxins; D008070:Lipopolysaccharides