Alterations produced by sertaconazole on the morphology and ultrastructure of Candida albicans.
We studied the changes produced in Candida albicans yeast cells after treatment in vitro with sertaconazole, with light microscopy, transmission and scanning electron microscopy. Four different concentrations were evaluated (10(-6) M, 10(-5) M, 10(-4) M, 10(-3) M) and two times of action (12 and 17 h) for each concentration. This new antimycotic agent shows a considerable destructive effect in C. albicans cells. The alterations produced by sertaconazole were already manifested after 12 h at the concentration of 10(-6) M and a strong fungicidal activity recorded at 10(-4) M.
Guarro
J
J
Figueras
M J
MJ
Cano
J
J
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000648:ultrastructure; D007093:Imidazoles / Q000494:pharmacology*; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D013876:Thiophenes / Q000494:pharmacology*
D000935:Antifungal Agents; D007093:Imidazoles; D013876:Thiophenes; C061131:sertaconazole