Gastrointestinal transit of Sinemet CR in healthy volunteers.
The gastrointestinal transit and systemic absorption of Sinemet CR (50/200) and standard Sinemet (25/100) have been studied in fasting and "fed" healthy human subjects. Both formulations were labeled with a gamma-emitting radionuclide, and their gastric emptying, colon arrival, and in vivo dissolution profiles were monitored using gamma scintigraphy. The standard dosage forms were found to disperse soon after administration and to empty rapidly from both the fasting and the "fed" stomach. The erosion of the controlled-release (CR) system was independent of food. Dosing after a light breakfast altered the gastric emptying profile of the CR formulation and led to significant differences in the plasma levels of levodopa.
Wilding
I R
IR
Department of Pharmaceutical Sciences, School of Pharmacy, University of Nottingham, England.
Davis
S S
SS
Melia
C D
CD
Hardy
J G
JG
Evans
D F
DF
Short
A H
AH
Sparrow
R A
RA
D000978:Antiparkinson Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001682:Biological Availability; D002230:Carbidopa / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004338:Drug Combinations / Q000008:administration & dosage / Q000493:pharmacokinetics; D004435:Eating; D005746:Gastric Emptying / Q000187:drug effects; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008297:Male; D011897:Random Allocation; D013607:Tablets
D000978:Antiparkinson Agents; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D013607:Tablets; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa