Reactivity of CO17-1A and B72.3 in benign and malignant pancreatic diseases.
The immunoreactivity of two monoclonal antibodies, CO17-1A (recognizing 17-1A antigen) and B72.3 (recognizing TAG-72), was examined in pancreatic tissues from individuals without pancreatic disease and from those with benign and malignant pancreatic disease. 17-1A antigen was found in all cells in the normal tissue, whereas TAG-72 was present in the duct cells in only one case. Both antigens were present in benign diseases; however, in some cells and in some conditions, TAG-72 was significantly less common (P less than .01 to .001) than 17-1A antigen. In pancreatic cancer, 17-1A antigen was present in 87% of cases and TAG-72 antigen was present in 92% of cases. The results indicate that B72.3 is more specific to pancreatic cancer than C017-1A.
Takiyama
Y
Y
The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha 68105.
Tempero
M A
MA
Takasaki
H
H
Onda
M
M
Tsuchiya
R
R
Büchler
M
M
Ness
M
M
Colcher
D
D
Schlom
J
J
Pour
P M
PM
D000208:Acute Disease; D000230:Adenocarcinoma / Q000032:analysis / Q000473:pathology*; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002908:Chronic Disease; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D010179:Pancreas / Q000032:analysis / Q000166:cytology* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000032:analysis / Q000473:pathology*; D010195:Pancreatitis / Q000473:pathology*; D012016:Reference Values
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006023:Glycoproteins; C050928:carcinoma-associated antigen 17-1A; C047052:tumor-associated antigen 72