Effect of oligomannoside-type glycopeptides in diarrheal disease of rabbits induced by Escherichia coli strain RDEC-1.
We examined the effects of a soluble receptor-like complex carbohydrate (an oligomannoside-type glycopeptide) on adherence of a type 1 fimbriated rabbit enteropathogen, Escherichia coli strain RDEC-1. Oligomannoside-type glycopeptide, but not a non-glycosylated peptide mixture used as control, inhibited adherence of type 1 fimbriated RDEC-1 to both rabbit ileal brush borders and guinea pig erythrocytes in vitro. In contrast, during RDEC-1 infection of rabbits the receptor-like oligomannoside did not affect the presence and severity of diarrhea, fecal shedding of organisms, luminal colonization by RDEC-1, or enteroadherence of organisms.
Sherman
P
P
Department of Pediatrics, Hospital for Sick Children, University of Toronto, Canada.
Soni
R
R
Del Vedovo
S
S
Neeser
J R
JR
D000818:Animals; D001422:Bacterial Adhesion; D002240:Carbohydrate Sequence; D046508:Culture Techniques; D003967:Diarrhea / Q000382:microbiology*; D004927:Escherichia coli Infections / Q000378:metabolism*; D005243:Feces / Q000382:microbiology; D006020:Glycopeptides / Q000378:metabolism*; D006168:Guinea Pigs; D008871:Microvilli; D009844:Oligosaccharides / Q000378:metabolism*; D011817:Rabbits
D006020:Glycopeptides; D009844:Oligosaccharides; C028569:oligomannoside