[Immunohistochemical detection of thyroglobulin].
An antiserum against human thyroglobulin isolated by gelfiltration from the human thyroid gland was raised in rabbits. The specificity of the antiserum to detect human thyroglobulin was determined by an immunoperoxidase technique on formalin-fixed and paraffin-embedded tissue sections of 17 primary thyroid carcinomas and 80 carcinomas of other origins, such as pancreas, colon, breast, bladder, ovary, testis, and larynx. Positive reactions to immunological staining were recorded only from differentiated thyroid carcinomas, while no reactions were exhibited by the other malignant tumours tested in this study.
Sturm
U
U
Institut für Pathologische Anatomie, Medizinischen Akademie Dresden.
Grossmann
H
H
Schuh
D
D
Zotter
S
S
Müller
M
M
D000230:Adenocarcinoma / Q000032:analysis*; D000818:Animals; D002291:Carcinoma, Papillary / Q000032:analysis*; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008297:Male; D011817:Rabbits; D013954:Thyroglobulin / Q000032:analysis*; D013964:Thyroid Neoplasms / Q000032:analysis*
D007106:Immune Sera; D013954:Thyroglobulin
Immunhistochemischer Nachweis von Thyreoglobulin.