title: The effect of 1% metronidazole gel in routine maintenance of persistent furcation involvement in human beings.
abstract: The aim of this study was to test adjunctive insertion of 1% metronidazole gel into furcation areas during periodontal maintenance. Ten patients were selected with paired, contralateral, Class II or III furcation involvements that also bled on constant force probing. Bleeding on probing (BOP) and gingival crevicular fluid (GCF) were measured as experimental variables. Plaque was assessed by dark-field microscopy (DFM). Following routine subgingival maintenance of these sites, a syringe was used to insert metronidazole or placebo gels into the furcations. Sites were re-examined 1 and 3 months after baseline. There was little change in either BOP or GCF. Marked longitudinal changes were found by DFM for both experimental and control sites. Experimental sites were not significantly different when compared with controls at the 5% level of probability.
authors.affiliation: Department of Oral Medicine and Periodontology, London Hospital Medical College, U.K.
authors.forename: I G
authors.initials: IG
authors.lastname: Needleman
authors.forename: T L
authors.initials: TL
authors.lastname: Watts
mesh_terms: D000328:Adult; D000368:Aged; D001419:Bacteria / Q000187:drug effects; D003131:Combined Modality Therapy; D016001:Confidence Intervals; D003692:Delayed-Action Preparations; D003773:Dental Plaque / Q000382:microbiology*; D005260:Female; D005782:Gels; D005883:Gingival Crevicular Fluid; D005884:Gingival Hemorrhage; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010510:Periodontal Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D013357:Subgingival Curettage / Q000009:adverse effects; D014092:Tooth Root
chemical_list: D003692:Delayed-Action Preparations; D005782:Gels; D008795:Metronidazole