Immunohistochemical detection of the c-erbB-2 proto-oncogene product in normal, benign and malignant cartilage tissues.
Benign and malignant cartilage tumours as well as normal cartilage were stained immunohistochemically with antibodies raised to a synthetic peptide from the sequence of the c-erbB-2 protein. Positive staining was present in 18/23 of the chondrosarcomas and in one case of osteochondroma. Normal and benign neoplastic cartilage tissues revealed negative results. It is concluded that expression of the c-erbB-2 protein may contribute to cell transformation in chondrosarcomas; it is not apparent whether the expression of c-erbB-2 protein in chondrosarcomas characterizes a subpopulation of different prognostic significance.
Wrba
F
F
Department of Pathology and Orthopedic Clinic, University of Vienna, Austria.
Gullick
W J
WJ
Fertl
H
H
Amann
G
G
Salzer-Kuntschik
M
M
D002356:Cartilage / Q000276:immunology*; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D002804:Chondroblastoma / Q000175:diagnosis / Q000378:metabolism; D002812:Chondroma / Q000175:diagnosis / Q000378:metabolism; D002813:Chondrosarcoma / Q000175:diagnosis / Q000378:metabolism; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D009372:Neoplasms, Connective Tissue / Q000175:diagnosis / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000032:analysis* / Q000276:immunology
D011518:Proto-Oncogene Proteins