title: Type beta transforming growth factor regulates expression of genes encoding bone matrix proteins.
abstract: TGF beta modulates the growth and differentiation of various cell types, in part by regulating the production of extracellular matrix proteins. In rat osteoblast-like cells TGF beta stimulates the production of collagen, osteopontin and osteonectin. On the other hand, TGF beta inhibits the production of osteocalcin, one of the most abundant non-collagenous bone matrix proteins, which is only expressed in osteoblasts. Inhibition of osteocalcin expression by TGF beta in the rat osteoblastic osteosarcoma, ROS 17/2.8 cells, occurs at least in part through transcriptional control.
authors.affiliation: Merck Sharp and Dohme Research Laboratories, West Point, PA.
authors.forename: M
authors.initials: M
authors.lastname: Noda
authors.forename: G A
authors.initials: GA
authors.lastname: Rodan
mesh_terms: D000818:Animals; D001857:Bone Matrix / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis; D005109:Extracellular Matrix / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D015675:Osteocalcin / Q000096:biosynthesis; D015676:Osteonectin / Q000096:biosynthesis; D053495:Osteopontin; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics; D012795:Sialoglycoproteins / Q000096:biosynthesis; D015291:Transforming Growth Factors / Q000502:physiology*
chemical_list: D015676:Osteonectin; D011506:Proteins; D012795:Sialoglycoproteins; C506897:Spp1 protein, rat; D015675:Osteocalcin; D053495:Osteopontin; D015291:Transforming Growth Factors; D003094:Collagen