title: Rapid decay of serum IgG recognizing gram-negative cell wall core antigens in neonatal calves.
abstract: Serum immunoglobulins of the IgG isotype recognizing common gram-negative cell core epitopes were serially measured, using a direct ELISA, on samples obtained from 20 neonatal Holstein calves. An R-mutant Escherichia coli (strain J5) was used as a plate antigen in this assay. Total serum IgG concentration was measured using radial immunodiffusion. Half-lives of core antigen-specific IgG (7.56 days) and total serum IgG (22.66 days) were dramatically different (P less than 0.0005). This may be an indication of cross-reactive consumption of core antigen-specific immunoglobulins.
authors.affiliation: Department of Clinical Pathology, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: V L
authors.initials: VL
authors.lastname: Douglas
authors.forename: J S
authors.initials: JS
authors.lastname: Cullor
authors.forename: J W
authors.initials: JW
authors.lastname: Tyler
authors.forename: M C
authors.initials: MC
authors.lastname: Thurmond
authors.forename: R B
authors.initials: RB
authors.lastname: Bushnell
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology*; D002417:Cattle / Q000276:immunology*; D002473:Cell Wall / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D004926:Escherichia coli / Q000276:immunology*; D006207:Half-Life; D007074:Immunoglobulin G / Q000032:analysis* / Q000276:immunology; D013997:Time Factors
chemical_list: D000942:Antigens, Bacterial; D007074:Immunoglobulin G