title: Interconversion of polyamines in wild-type strains and mutants of yeasts and the effects of polyamines on their growth.
abstract: Yeasts of wild-type strains, such as Saccharomyces cerevisiae, Schizosaccharomyces pombe and Candida albicans were shown to have the ability to form aminopropylcadaverine and aminopropylhomospermidine from cadaverine and homospermidine, respectively. A polyamine autotroph S. cerevisiae 179-5, which lacks ornithine decarboxylase, produced both aminopropylcadaverine and aminopropylhomospermidine, while another mutant S. cerevisiae Y 260 A, which lacks spermine synthase, formed only aminopropylcadaverine. Naturally-occurring triamines and tetraamines except norspermidine and norspermine stimulated the growth of S. cerevisiae 179-5. All the six aliphatic diamines with carbon chain length ranging from one to six were effective in activating the growth of S. cerevisiae 179-5, though all of them were not converted to either triamines or tetraamines.
authors.affiliation: College of Medical Care and Technology, Gunma University, Maebashi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hamana
authors.forename: S
authors.initials: S
authors.lastname: Matsuzaki
authors.forename: K
authors.initials: K
authors.lastname: Hosaka
authors.forename: S
authors.initials: S
authors.lastname: Yamashita
mesh_terms: D002176:Candida albicans / Q000187:drug effects / Q000235:genetics / Q000254:growth & development*; D002851:Chromatography, High Pressure Liquid; D009154:Mutation; D011073:Polyamines / Q000032:analysis / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics / Q000254:growth & development*; D004718:Saccharomycetales / Q000254:growth & development*; D012568:Schizosaccharomyces / Q000187:drug effects / Q000235:genetics / Q000254:growth & development*
chemical_list: D011073:Polyamines