Metabolic activation of aromatic amine carcinogens in vitro and in vivo.
Beland
F A
FA
National Center for Toxicological Research, Jefferson, Arkansas 72079.
D015073:2-Acetylaminofluorene / Q000378:metabolism / Q000633:toxicity; D000107:Acetylation; D000588:Amines / Q000378:metabolism / Q000493:pharmacokinetics*; D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism / Q000493:pharmacokinetics*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006900:Hydroxylation; D007527:Isoenzymes / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000139:chemically induced / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009928:Organ Specificity; D051381:Rats; D013379:Substrate Specificity; D001743:Urinary Bladder / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000378:metabolism
D000588:Amines; D002273:Carcinogens; D007527:Isoenzymes; D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D015073:2-Acetylaminofluorene