title: A new test for specific IgE to inhalant allergens (Phadiatop) in the screening of immediate respiratory hypersensitivity states.
abstract: Three hundred recruits were classified as either allergic or nonallergic to inhalant allergens on the basis of history, physical examination, skin testing, and RAST. Forty-nine (16.3%) were classified as allergic as they were affected by oculorhinitis and/or asthma. This diagnosis was compared with results obtained with PRIST and with a new commercially available multi-RAST test for inhalant allergy, Phadiatop (Pharmacia). Sixty subjects (20%), including all 49 allergic subjects, scored positive in the Phadiatop assay (100% sensitivity) while PRIST (cut-off 220 IU/mL) identified only 20/49 allergics (40.8% sensitivity). The correlation between RAST and Phadiatop was excellent. Phadiatop is much more sensitive than PRIST; furthermore, Phadiatop is easier, less expensive, and as reliable as RAST for use in mass screening programs.
authors.affiliation: Department of Medicine, DASRS, Pratica di Mare, Italy.
authors.forename: P M
authors.initials: PM
authors.lastname: Matricardi
authors.forename: A
authors.initials: A
authors.lastname: Fattorossi
authors.forename: R
authors.initials: R
authors.lastname: Nisini
authors.forename: S
authors.initials: S
authors.lastname: Le Moli
authors.forename: P P
authors.initials: PP
authors.lastname: Castagliuolo
authors.forename: R
authors.initials: R
authors.lastname: D'Amelio
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens; D000918:Antibody Specificity / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007073:Immunoglobulin E / Q000032:analysis*; D007558:Italy; D008297:Male; D008403:Mass Screening / Q000379:methods*; D011852:Radioallergosorbent Test; D011864:Radioimmunosorbent Test; D012130:Respiratory Hypersensitivity / Q000175:diagnosis / Q000517:prevention & control*; D012882:Skin Tests
chemical_list: D000485:Allergens; D007073:Immunoglobulin E