title: Biosynthesis and secretion of insulin.
abstract: The mechanisms involved in the biosynthesis, storage and secretion of insulin in the normal pancreatic B-cell have been the subject of intensive investigation during the last twenty years. As a result of this activity a relatively clear picture has emerged about the basic processes involved, and increasing information is available of their regulation and integration. Most of this information is derived from studies with rodent islets, but in general it appears to be applicable to the human B-cell. The article attempts to provide an overview from the vast literature on pancreatic B-cell function; it cannot be entirely comprehensive within the space available.
authors.forename: S L
authors.initials: SL
authors.lastname: Howell
authors.forename: G S
authors.initials: GS
authors.lastname: Bird
mesh_terms: D002118:Calcium / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000096:biosynthesis* / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism
chemical_list: D007328:Insulin; D005947:Glucose; D002118:Calcium