title: Clonidine transdermal patches for use in outpatient opiate withdrawal.
abstract: We conducted a study to assess the clinical usefulness of transdermal clonidine for heroin detoxification in an outpatient drug treatment clinic. Twenty-two young otherwise healthy heroin addicts participated. Outcome was assessed on the basis of (a) hypotension and other side effects of clonidine; (b) patient retention; (c) concomitant drug use; (d) subjective symptoms of withdrawal; and (e) objective signs of withdrawal. Side effects were present but in no case necessitated discontinuation of treatment. Drop-out rates were equal to conventional treatment offered at the clinic. The availability of clonidine broadens the therapeutic options available to patients and clinicians in treating the opiate-addicted patient. Transdermal clonidine offers several advantages over the oral form: patches can be applied weekly, fewer supplemental medications are required, and patches supply an even blood level of medication. A protocol for use is recommended.
authors.affiliation: Adult Outpatient Chemical Dependency Center, Mills-Peninsula Hospital, Burlingame, CA 94010.
authors.forename: L
authors.initials: L
authors.lastname: Spencer
authors.forename: M
authors.initials: M
authors.lastname: Gregory
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000553:Ambulatory Care; D002986:Clinical Trials as Topic; D003000:Clonidine / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D003932:Heroin / Q000009:adverse effects*; D006556:Heroin Dependence / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D013375:Substance Withdrawal Syndrome / Q000534:rehabilitation*
chemical_list: D003932:Heroin; D003000:Clonidine