[Evaluation of liver monooxygenase function by the kinetics of antipyrine and its metabolites in liquid media of the body].
The presented findings indicate that the determination in the blood or saliva of antipyrine concentration kinetics as well as the profile and the ratio of the products of its hydroxylation in the urine makes it possible to evaluate under clinical conditions the activity of the hydroxylating (monooxygenase) system of the human liver and, consequently, the state of its main therapeutic-metabolizing function that is undoubtedly important for the optimization of pharmacotherapy.
Zavodnik
L B
LB
Lukienko
P I
PI
Bushma
M I
MI
D000983:Antipyrine / Q000493:pharmacokinetics*; D001826:Body Fluids / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000201:enzymology*; D010105:Oxygenases / Q000378:metabolism*
D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D000983:Antipyrine
Otsenka monooksigenaznoĭ funktsii pecheni po kinetike antipirina i ego metabolitov v zhidkikh sredakh organizma.