Serotonin and depression: old problems and new data.
1. Several lines of evidence implicating some dysfunction or alteration to brain serotonergic systems in depressive states are summarized. 2. Some aspects of the interactions between the 5-HT and catecholamine pathways in the action of antidepressant drugs are examined. 3. Finally, the important role of NA modulation of serotonergic activity in the action of antidepressants is suggested.
Plaznik
A
A
Department of Pharmacology and Physiology of the Nervous System, Psychoneurological Institute, Warsaw, Poland.
Kostowski
W
W
Archer
T
T
D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D003866:Depressive Disorder / Q000378:metabolism*; D006801:Humans; D012701:Serotonin / Q000378:metabolism*
D002395:Catecholamines; D012701:Serotonin