Hormonal imprinting in adults: insulin exposure during regeneration alters the later binding capacity of the hepatic insulin receptors.
Insulin treatment following subtotal hepatectomy caused a long lasting change in the binding capacity of hepatic insulin receptors. The insulin binding increased in females and decreased in males in the insulin treated animals (during regeneration) fourteen days after the operation. The tendency of changes was very similar to those which had been caused by neonatal insulin treatment.
Csaba
G
G
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Inczefi-Gonda
A
A
Dobozy
O
O
D000818:Animals; D002454:Cell Differentiation; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008115:Liver Regeneration / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000187:drug effects* / Q000378:metabolism
D007328:Insulin; D011972:Receptor, Insulin