title: Clinical testing of a new, low-flux polysulfone membrane. Results of a 26-week study.
abstract: In a 6-month study, a new hollow-fiber (HF) dialyzer with a modified polysulfone (PS) membrane was evaluated in 12 hemodialysis patients. Seven of them had previously used a cuprophane (CU) HF and five a polymethylmethacrylate (PMMA) HF dialyzer. The PS dialyzer reduced the concentration of serum creatinine by 54 +/- 5% (SD), that of urea by 59 +/- 5%, that of urate by 62 +/- 6% and that of phosphate by 40 +/- 12%; the mean urea index (Kt/V) was 0.9. Heparin consumption diminished with the PS dialyzer compared with the PMMA dialyzer. The serum predialysis beta-2-microglobulin (beta 2M) concentrations rose by 5.4 mg/l (mean). The intradialytic beta 2M measurements showed insignificant changes in all the membranes studied. Eosinophilia was initially observed in 4/12 (33%) of the patients, all using an ethylene oxide (ETO)-sterilized CU dialyzer. At the end of the study this figure had decreased to 1/12 (8%). The serum IgE concentrations also decreased significantly. IgE class antibodies to ETO were initially detected in 2 patients. The level decreased clearly in 1 of them after switching to the PS dialyzer. The new PS dialyzer was found to be effective, possibly less allergenic and, owing to its moderate hydraulic permeability, suitable for routine dialyses.
authors.affiliation: Helsinki University Central Hospital, Fourth Department of Medicine, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Honkanen
authors.forename: C
authors.initials: C
authors.lastname: Grönhagen-Riska
authors.forename: A M
authors.initials: AM
authors.lastname: Teppo
authors.forename: U
authors.initials: U
authors.lastname: Hiltunen
mesh_terms: D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D004802:Eosinophilia / Q000097:blood; D005027:Ethylene Oxide / Q000276:immunology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism; D007958:Leukocyte Count; D008137:Longitudinal Studies; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010976:Platelet Count; D011108:Polymers; D006435:Renal Dialysis / Q000295:instrumentation*; D013450:Sulfones; D014508:Urea / Q000097:blood; D001613:beta 2-Microglobulin / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; D001613:beta 2-Microglobulin; C017662:polysulfone P 1700; D007073:Immunoglobulin E; D014508:Urea; D005027:Ethylene Oxide