title: Diagnostic accuracy of the immunocytochemical study of body fluids.
abstract: The diagnostic accuracy of the immunocytochemical characterization of body fluids was evaluated in 100 specimens (35 pleural, 40 peritoneal, 7 pericardial and 18 cerebrospinal [CSF] fluids) in comparison with routine morphologic examination. The immunochemical markers used for all specimens were common-leukocyte antigen, epithelial membrane antigen, epithelial keratin and desmin. Additional immunocytochemical studies for neurofilaments, glial fibrillary acidic protein, vimentin and melanoma-associated antigen were performed on the CSF specimens. The study confirmed the accuracy of the immunocytochemical characterization of cells in body fluids using a panel of immunocytochemical stains. These methods are recommended as an adjunct to improve the accuracy of the cytologic diagnosis of body fluids, especially in cases with diagnostically difficult morphologic features.
authors.affiliation: Division of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905.
authors.forename: C Y
authors.initials: CY
authors.lastname: Li
authors.forename: S C
authors.initials: SC
authors.lastname: Ziesmer
authors.forename: Y C
authors.initials: YC
authors.lastname: Wong
authors.forename: L T
authors.initials: LT
authors.lastname: Yam
mesh_terms: D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis; D001202:Ascitic Fluid / Q000166:cytology / Q000276:immunology; D001826:Body Fluids / Q000166:cytology*; D002555:Cerebrospinal Fluid / Q000166:cytology / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry / Q000379:methods*; D007159:Immunologic Tests; D009369:Neoplasms / Q000175:diagnosis* / Q000276:immunology; D010496:Pericardium / Q000166:cytology / Q000276:immunology; D010994:Pleura / Q000166:cytology
chemical_list: D000911:Antibodies, Monoclonal; D000941:Antigens