title: Effect of simvastatin on plasma lipids, apolipoproteins and lipoprotein particles in patients with primary hypercholesterolaemia.
abstract: The effect of treatment with simvastatin, a new HMG-CoA reductase inhibitor, has been investigated in 27 patients with primary hypercholesterolaemia. It produced a significant decrease of cholesterol and phospholipids in plasma, LDL and apolipoprotein B-containing lipoproteins. Plasma apolipoproteins B, C-III and E were also significantly lowered. The concentration of lipoprotein particles recognized by monoclonal antibodies (BL3, BL5 and BL7), associated with atherosclerotic disease, was also lowered by the treatment. Lipoproteins LpA-II:A-I were not changed, while LpA-I, which has been suggested to be the protective fraction of the apo A-I-containing lipoproteins, was slightly and inconsistently increased.
authors.affiliation: Serlia, Institut Pasteur, Lille, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Bard
authors.forename: G
authors.initials: G
authors.lastname: Luc
authors.forename: P
authors.initials: P
authors.lastname: Douste-Blazy
authors.forename: P
authors.initials: P
authors.lastname: Drouin
authors.forename: O
authors.initials: O
authors.lastname: Ziegler
authors.forename: B
authors.initials: B
authors.lastname: Jacotot
authors.forename: C
authors.initials: C
authors.lastname: Dachet
authors.forename: J L
authors.initials: JL
authors.lastname: De Gennes
authors.forename: J C
authors.initials: JC
authors.lastname: Fruchart
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001053:Apolipoproteins / Q000097:blood*; D002784:Cholesterol / Q000096:biosynthesis* / Q000097:blood; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006937:Hypercholesterolemia / Q000188:drug therapy*; D007124:Immunoenzyme Techniques; D008074:Lipoproteins / Q000097:blood*; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood*; D019821:Simvastatin; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D001053:Apolipoproteins; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008074:Lipoproteins; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol; D008148:Lovastatin; D019821:Simvastatin