Induction of ovulation with gonadotrophin-releasing hormone--life-table analysis of 50 courses of treatment.
Ovulation induction by means of the pulsatile subcutaneous administration of gonadotrophin-releasing hormone by way of an infusion pump is described. The clinical outcome in 50 courses of treatment, which totalled 116 treatment cycles, was analysed and was compared with the pregnancy rates that were obtained with the administration of human pituitary gonadotrophins. We found that the pregnancy rates for these two treatments were similar. We also have shown that for those women who ovulated as a result of such treatment the conception rates were similar to those in ovulatory women who had discontinued contraception. We conclude that gonadotrophin-releasing hormone has an important place among the ovulation-induction agents.
Kovacs
G T
GT
Medical Research Centre, Prince Henry's Hospital Campus, Monash Medical Centre, Melbourne, VIC.
Phillips
S
S
Healy
D L
DL
Burger
H G
HG
D000206:Actuarial Analysis; D000328:Adult; D000858:Anovulation / Q000503:physiopathology; D001824:Body Constitution; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007279:Injections, Subcutaneous; D010060:Ovulation / Q000187:drug effects; D010062:Ovulation Induction / Q000379:methods; D010906:Pituitary Hormone-Releasing Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D012189:Retrospective Studies
D010906:Pituitary Hormone-Releasing Hormones