Enhancement of c-sis protooncogene transcription in bronchoalveolar mononuclear cells from patients with autoimmune diseases with lung involvement.
The expression of c-sis protooncogene in bronchoalveolar mononuclear cells has been studied in patients with autoimmune diseases with lung involvement. By nuclear run on transcription assay, we examined the transcriptional level of c-sis protooncogene in bronchoalveolar mononuclear cells from the patients. We demonstrated the enhancement of c-sis protooncogene expression in bronchoalveolar mononuclear cells from patients with autoimmune diseases with lung involvement in this study. It could suggest that the enhancement of c-sis transcription, which we first demonstrated, is involved in the existence of activated steps of bronchoalveolar mononuclear cells from patients with autoimmune diseases with lung involvement.
Deguchi
Y
Y
Third Department of Internal Medicine, Osaka University School of Medicine, Japan.
Kishimoto
S
S
D001327:Autoimmune Diseases / Q000235:genetics* / Q000378:metabolism; D015152:Blotting, Northern; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D008171:Lung Diseases / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism*; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D020574:Proto-Oncogene Proteins c-sis; D011519:Proto-Oncogenes; D011650:Pulmonary Alveoli / Q000503:physiopathology; D014158:Transcription, Genetic
D010982:Platelet-Derived Growth Factor; D011518:Proto-Oncogene Proteins; D020574:Proto-Oncogene Proteins c-sis; D011505:Protein-Tyrosine Kinases