title: Posterior vitreous fluorophotometry. II. Comparison of diabetic patients and controls with the use of a new analysis procedure.
abstract: We used a new computerized procedure to analyze posterior vitreous fluorophotometry scans, obtained with a commercial fluorophotometer (Fluorotron Master Coherent, Palo Alto, Calif), in insulin-dependent diabetic patients and controls. Diabetic patients with minimal retinopathy had significantly higher effective fluorescein vitreous diffusivity and 30-minute 3-mm vitreous fluorescence values than either controls or diabetic patients with no retinopathy. However, there was no significant difference between the groups for the apparent permeability of the blood-retinal barrier to fluorescein. These results suggest the possibility that the higher 3-mm fluorescence levels found in the diabetic patients with minimal retinopathy may result in part from enhanced movement of fluorescein through the vitreous.
authors.affiliation: Clinical Branch, National Eye Institute, Bethesda, MD 20892.
authors.forename: M S
authors.initials: MS
authors.lastname: Roy
authors.forename: P M
authors.initials: PM
authors.lastname: Bungay
authors.forename: R F
authors.initials: RF
authors.lastname: Bonner
mesh_terms: D000328:Adult; D001813:Blood-Retinal Barrier; D002199:Capillary Permeability; D003920:Diabetes Mellitus / Q000378:metabolism*; D003936:Diagnosis, Computer-Assisted; D005260:Female; D019793:Fluorescein; D005452:Fluoresceins; D005453:Fluorescence; D005470:Fluorometry; D006801:Humans; D008297:Male; D010783:Photometry; D012016:Reference Values; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D005452:Fluoresceins; D019793:Fluorescein