title: Paleopathological study on malignant bone tumor in Japan. Differential diagnosis on osteolytic lesions in the skull.
abstract: This report concerns a probable case of metastatic malignant bone tumor in the skull of a prehistoric skeleton from Honshu Island in Japan. In gross observation, a fragmental skull of an adult showed many osteolytic lesions without any healing processes which could be also ascertained by roentgenological studies. Besides this case, four cases with a diagnosis of malignant bone tumor have so far been reported among archeological skeletal remains in Japan. This case from the prehistoric "Jomon" period is certainly the oldest case showing such malignant tumorous change in the skeleton. In this report, the osteolytic changes in the "Jomon" skull are described in detail and compared with two other cases showing the same osteolytic changes. The morphology and distribution of the lesions as well as the sex and age of the individual are discussed to make an adequate differential diagnosis for malignant osteolytic lesions in the skeleton.
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D049690:History, Ancient; D006801:Humans; D007564:Japan; D008297:Male; D010164:Paleopathology; D012886:Skull / Q000473:pathology*; D012888:Skull Neoplasms / Q000175:diagnosis* / Q000556:secondary