The discovery of gene amplification in mammalian cells: to be in the right place at the right time.
The constancy of the genome structure of an organism has been accepted dogma for a number of decades. The genetic variegation of maize as described by McClintock in the 1940s and subsequently shown to be mediated by transposable elements indicated a degree of genomic fluidity not appreciated previously. The discovery of gene amplification in somatic mammalian cells in 1977 has added a new component to the phenomenon of genomic fluidity, which has implications for various subdisciplines of biology.
Schimke
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D000818:Animals; D002478:Cells, Cultured; D003001:Cloning, Molecular; D003582:Cytogenetics; D004247:DNA / Q000235:genetics; D005784:Gene Amplification; D008322:Mammals / Q000235:genetics*
D004247:DNA