[Correlation of complement activation, cytokine liberation and beta 2 microglobulin in the use of various dialysis and hemofiltration membranes].
The release of biological active factors from blood cells, e.g. interleukin 1, is of importance with regard to the bioavailability testing of membranes for extracorporeal blood purification. The data from an in vitro system of cytokine release may show a connection between complement activation and cytokine (interleukin) release of membranes. In contrast the results of the generation rate of beta 2-microglobulin did show no definite reference to complement activation or cytokine release. Further time-dependent investigations of the generation rate beta 2-microglobulin are necessary.
Falkenhagen
D
D
Klinik für Innere Medizin, Wilhelm-Pieck-Universität, Rostock, DDR.
Thomaneck
U
U
Brown
G S
GS
Werner
H
H
Klinkmann
H
H
D001672:Biocompatible Materials; D003167:Complement Activation / Q000276:immunology*; D006440:Hemofiltration / Q000295:instrumentation*; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000628:therapy; D007688:Kidneys, Artificial; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008567:Membranes, Artificial; D013499:Surface Properties; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D001613:beta 2-Microglobulin / Q000378:metabolism*
D001672:Biocompatible Materials; D007375:Interleukin-1; D008567:Membranes, Artificial; D014409:Tumor Necrosis Factor-alpha; D001613:beta 2-Microglobulin
Zusammenhang zwischen Komplementaktivierung, Zytokinfreisetzung und beta 2-Mikroglobulin bei der Anwendung verschiedener Dialyse- bzw. Hämofiltrations-Membranen.