[Significance of endothelin in shock pathogenesis].
Endothelin is a recently discovered bioactive peptide produced by vascular endothelial cells. By means of specific radioimmunoassay we found that plasma endothelin level in patients with late septic shock was significantly increased. And a typical shock model in healthy rats was reproduced by continuous infusion of endothelin (endothelin shock). Infusion of endothelin at a small dose to hemorrhagic shocked rats deteriorated the shock process and resulted in an irreversible development. From these results it is suggested that endothelin may be an endogenous injury-inducing factor, acting as one of the important humoral factors involved in shock pathogenesis.
Tang
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Xie
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Li
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Li
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Song
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Shao
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Tang
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Su
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D000818:Animals; D001794:Blood Pressure; D016232:Endothelins; D006801:Humans; D008297:Male; D010455:Peptides / Q000097:blood* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000188:drug therapy; D012772:Shock, Septic / Q000097:blood* / Q000209:etiology
D016232:Endothelins; D010455:Peptides