title: Acute vincristine neurotoxicity in the presence of hereditary motor and sensory neuropathy type I.
abstract: Acute vincristine neurotoxicity leading to a severe motor and sensory neuropathy has been noted in patients with hereditary motor and sensory neuropathy type I (HMSN-I). The case of a 2-year-old boy with acute lymphocytic leukemia and HMSN-I is reported, and additional cases from the literature are reviewed. Severe vincristine neurotoxicity in patients with HMSN-I may be secondary to impairment of both slow and- fast axonal transport. Vincristine should be used with caution in patients with a family history of polyneuropathy.
authors.affiliation: Department of Neurology, School of Medicine, University of California, Davis 95817.
authors.forename: S A
authors.initials: SA
authors.lastname: McGuire
authors.forename: S M
authors.initials: SM
authors.lastname: Gospe
authors.forename: G
authors.initials: G
authors.lastname: Dahl
mesh_terms: D002607:Charcot-Marie-Tooth Disease / Q000150:complications*; D002675:Child, Preschool; D006801:Humans; D008297:Male; D009134:Muscular Atrophy, Spinal; D010525:Peripheral Nerves / Q000187:drug effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D014750:Vincristine / Q000009:adverse effects*
chemical_list: D014750:Vincristine