title: Double blind study of a valerian preparation.
abstract: Valerian root contains two substances of special pharmacological interest--valepotriates and sesquiterpenes. The former, which has been used for standardization of the drug, is cytotoxic. The latter has no such effect. Both have sedative effects. A double blind test has been carried out on a preparation (VALERINA NATT) containing primarily sesquiterpenes. When compared with placebo it showed a good and significant effect on poor sleep (p less than 0.001). Forty-four percent reported perfect sleep and 89% reported improved sleep from the preparation. No side effects were observed.
authors.affiliation: Foellinge Health Center, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Lindahl
authors.forename: L
authors.initials: L
authors.lastname: Lindwall
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004339:Drug Compounding; D005260:Female; D006801:Humans; D039823:Iridoids; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D011714:Pyrans / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000032:analysis / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects*; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D014632:Valerian
chemical_list: D039823:Iridoids; D010936:Plant Extracts; D011714:Pyrans; D012717:Sesquiterpenes; C009643:valtrates (combination)