The penetration of aztreonam, a monobactam antibiotic, into intra-abdominal abscesses.
We have studied the penetration of aztreonam into pus with a low mortality intra-abdominal abscess model in the Wistar rat. The mean peak serum concentration (standard error) of aztreonam was 74.6 +/- 9.88 mg/l at 30 min falling to 2.31 +/- 1.28 mg/l at 8 h. The mean concentration in pus was 17.04 +/- 2.01 mg/l at 2 h and was 14.47 +/- 2.23 mg/l at 8 h. These concentrations are in excess of the MICs of most Gram-negative aerobic bacilli commonly isolated from intra-abdominal abscesses.
Youngs
D J
DJ
Department of Microbiology, General Hospital, Birmingham, UK.
Burdon
D W
DW
Keighley
M R
MR
D000005:Abdomen; D000038:Abscess / Q000378:metabolism*; D000818:Animals; D001398:Aztreonam / Q000493:pharmacokinetics*; D004926:Escherichia coli / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008297:Male; D008795:Metronidazole / Q000494:pharmacology; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D013492:Suppuration / Q000378:metabolism; D001618:beta-Lactamases / Q000378:metabolism
D008795:Metronidazole; D001618:beta-Lactamases; D001398:Aztreonam