title: Ethanol-associated metabolic disorders.
abstract: The ingestion of alcohol, both intermittently and habitually, results in significant patient morbidity and mortality and stresses an already compromised socioeconomic system. Ethanol can interact with normal metabolic pathways to produce a variety of life-threatening abnormalities, particularly in those with underlying poor nutritional status, as is found in many alcohol users. Once identified, the metabolic derangements associated with alcohol use generally respond well to therapeutic interventions. The recurrence rate, however, is extremely high. Any attempt at long-term solutions must involve extensive rehabilitative services. Current research is directed largely toward improving survival from alcohol-related illnesses such as cirrhosis and cardiac disease. We must focus our efforts on the social implications of alcoholism, providing medical support, counseling, and rehabilitation to affected persons. Since alcohol-related problems present most frequently to the Emergency Department, it is appropriate that the emergency physician take the first step in attacking this disease, a step that may be as simple as a referral for detoxification or social services support.
authors.affiliation: New York City Poison Control Center, New York.
authors.forename: R S
authors.initials: RS
authors.lastname: Hoffman
authors.forename: L R
authors.initials: LR
authors.lastname: Goldfrank
mesh_terms: D000138:Acidosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D000437:Alcoholism / Q000150:complications*; D001602:Beriberi / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D000431:Ethanol / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D008275:Magnesium Deficiency / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008659:Metabolic Diseases / Q000209:etiology*; D009525:Niacin / Q000172:deficiency; D010383:Pellagra / Q000175:diagnosis / Q000209:etiology; D013832:Thiamine Deficiency / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
chemical_list: D009525:Niacin; D000431:Ethanol