Multicentre experience in the treatment of burns with autologous and allogenic cultured epithelium, fresh or preserved in a frozen state.
This report describes the clinical results obtained from a multicentre experience of the use of autologous and allogenic cultured human epidermal cells in the treatment of partial and full skin thickness burns. A laboratory has been organized to supply cultured epithelium to Burns Units in different cities. From May 1986 to December 1988, 58 patients with an age range of 1 to 59 years, and with burns covering between 7 and 95 per cent of the body surface area, have been treated. Graftable cultured epithelium can be frozen and remain viable if stored in a skin bank. Such grafts were used successfully to treat patients with partial and full skin thickness wounds.
De Luca
M
M
Laboratory of Cell Differentiation, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
Albanese
E
E
Bondanza
S
S
Megna
M
M
Ugozzoli
L
L
Molina
F
F
Cancedda
R
R
Santi
P L
PL
Bormioli
M
M
Stella
M
M
D000293:Adolescent; D000328:Adult; D001458:Bandages; D001684:Biological Dressings; D002056:Burns / Q000473:pathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D046508:Culture Techniques; D005615:Freezing; D006085:Graft Survival; D006801:Humans; D007223:Infant; D008854:Microscopy, Electron; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011183:Postoperative Complications / Q000473:pathology; D012867:Skin / Q000473:pathology; D016038:Skin Transplantation; D014021:Tissue Preservation; D014945:Wound Healing