Dendritic cells and scavenger macrophages in pancreatic islets of prediabetic BB rats.
Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease whose notorious pathologic feature is insulitis accompanied by destruction of beta-cells. In this morphological study, we examined the pancreatic events during the onset of diabetes in spontaneously diabetic BB/Organon rats. Dendritic cells were the first cells to accumulate around the islets, followed by lymphocytes. Scavenger macrophages and MHC class II-positive beta-cells were only seen late in the disease. These observations suggest a role for antigen-presenting dendritic cells in the onset of the beta-cell-specific autoimmune reaction and emphasize the necessity to distinguish between the several monocyte-macrophage subtypes in studies on the pathogenesis of IDDM.
Voorbij
H A
HA
Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
Jeucken
P H
PH
Kabel
P J
PJ
De Haan
M
M
Drexhage
H A
HA
D000818:Animals; D000911:Antibodies, Monoclonal; D003713:Dendritic Cells / Q000473:pathology*; D003921:Diabetes Mellitus, Experimental / Q000473:pathology; D005260:Female; D007515:Islets of Langerhans / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology*; D008297:Male; D011236:Prediabetic State / Q000473:pathology*; D051381:Rats; D011913:Rats, Inbred BB
D000911:Antibodies, Monoclonal