title: Development of recombinant hirudin as a therapeutic anticoagulant and antithrombotic agent: some objective considerations.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Loyola University Medical Center, Maywood, Illinois 60153.
authors.forename: J M
authors.initials: JM
authors.lastname: Walenga
authors.forename: R
authors.initials: R
authors.lastname: Pifarre
authors.forename: D A
authors.initials: DA
authors.lastname: Hoppensteadt
authors.forename: J
authors.initials: J
authors.lastname: Fareed
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests; D006470:Hemorrhage / Q000139:chemically induced; D024764:Hirudin Therapy; D006629:Hirudins / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity; D011994:Recombinant Proteins / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D013917:Thrombin / Q000037:antagonists & inhibitors; D013927:Thrombosis / Q000517:prevention & control*
chemical_list: D006629:Hirudins; D011994:Recombinant Proteins; D013917:Thrombin