title: Molecular basis of cisplatin resistance in human carcinomas: model systems and patients.
abstract: In this review, cisplatin resistance will be summarized. We will discuss characteristics of potential mechanisms of resistance in tissues from patients with ovarian, colon and breast carcinoma. Secondly, a new molecular biology assay will be discussed which detects changes in gene expression in cisplatin-resistant cells. Finally, based on the biochemical and molecular properties of cisplatin-resistant tumors, new strategies to exploit or circumvent cisplatin resistance in human tumors will be entertained.
authors.affiliation: Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA 91010.
authors.forename: K J
authors.initials: KJ
authors.lastname: Scanlon
authors.forename: M
authors.initials: M
authors.lastname: Kashani-Sabet
authors.forename: H
authors.initials: H
authors.lastname: Miyachi
authors.forename: L C
authors.initials: LC
authors.lastname: Sowers
authors.forename: J
authors.initials: J
authors.lastname: Rossi
mesh_terms: D002945:Cisplatin / Q000627:therapeutic use*; D004260:DNA Repair; D004261:DNA Replication; D004351:Drug Resistance; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D009857:Oncogenes; D013940:Thymidylate Synthase / Q000378:metabolism
chemical_list: D013940:Thymidylate Synthase; D002945:Cisplatin