Immunological findings in patients with chronically recurrent vaginal candidosis and new therapeutic approaches.
Eighteen patients with chronically recurrent vaginal candidosis showed low T-lymphocyte counts twice as frequent as a control group of 55 women. The patients were treated with azoles locally and lymphocyte stimulating pentapeptide thymopentin. The prolongation of disease-free intervals and a cure was mainly seen in the patients with low T-cell values before therapy. In vitro-proliferation assays upon stimulation with Candida albicans bore no correlation with the course of the disease. We suspect a failure in the co-operation of the immune cells, caused by differing strong responses to the Candida albicans stimulation.
Mendling
W
W
Koldovsky
U
U
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy / Q000276:immunology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D010446:Peptide Fragments / Q000627:therapeutic use; D012008:Recurrence; D013601:T-Lymphocytes / Q000276:immunology*; D016305:Thymopentin; D013946:Thymopoietins / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D010446:Peptide Fragments; D013946:Thymopoietins; D016305:Thymopentin