title: Secretion of islet amyloid polypeptide in response to glucose.
abstract: The content of islet amyloid polypeptide (IAPP) in isolated rat pancreatic islets was determined by a radioimmunoassay. Reverse-phase high-performance liquid chromatography analysis revealed that a main peak of IAPP immunoreactivity in the extracts from the islets corresponded to a synthetic rat IAPP. Secretion of IAPP from the cells is regulated by the extracellular glucose concentration. Thus, IAPP may be a novel regulator for glucose homeostasis and changes in the secretion perhaps relate to insular amyloid deposits and impaired glucose tolerance in type 2 diabetes mellitus.
authors.affiliation: Second Department of Internal Medicine, Chiba University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kanatsuka
authors.forename: H
authors.initials: H
authors.lastname: Makino
authors.forename: H
authors.initials: H
authors.lastname: Ohsawa
authors.forename: Y
authors.initials: Y
authors.lastname: Tokuyama
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Adachi
mesh_terms: D000682:Amyloid / Q000378:metabolism*; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology*; D066298:In Vitro Techniques; D058228:Islet Amyloid Polypeptide; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D000682:Amyloid; D058228:Islet Amyloid Polypeptide; D005947:Glucose