Metabolic effects of intraruminal administration of 1,3-butanediol or tributyrin in lactating goats.
Acute effects of dietary 1,3-butanediol and tributyrin on concentrations of glucose, beta-hydroxybutyrate, and insulin in plasma were compared in lactating goats. In Experiment 1, glucose was decreased by intraruminal administration of 75 or 150 g of 1,3-butanediol or by 84 or 168 g of tributyrin. Tributyrin caused transient hyperglycemia immediately after administration. beta-Hydroxybutyrate was increased in a dose-dependent manner by tributyrin and increased independently of dose by 1,3-butanediol. Tributyrin, but not 1,3-butanediol. Tributyrin, but not 1,3-butanediol, caused large increases of insulin in plasma. In Experiment 2, 75 g of 1,3-butanediol or 84 g of tributyrin administered intraruminally decreased glucose, whereas 73 g of butyric acid (pH 5.6) increased glucose compared with water or 25.6 g of glycerol. All treatments produced transient hyperglycemia immediately after administration. Tributyrin, butyric acid, or 1,3-butanediol greatly increased beta-hydroxybutyrate compared with administration of water or glycerol. Concentrations of beta-hydroxybutyrate in both experiments increased more slowly for 1,3-butanediol than for tributyrin. Both 1,3-butanediol and tributyrin decreased glucose and increased beta-hydroxybutyrate. Because 1,3-butanediol does not stimulate increases of insulin in plasma, it may be more desirable than tributyrin for inducing metabolic changes characteristic of lactation ketosis.
Drackley
J K
JK
Department of Animal Science, Iowa State University, Ames 50011.
Zhang
Y
Y
Amaral
D M
DM
Young
J W
JW
D020155:3-Hydroxybutyric Acid; D000138:Acidosis / Q000139:chemically induced*; D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002072:Butylene Glycols / Q000494:pharmacology*; D005260:Female; D015511:Goat Diseases / Q000139:chemically induced / Q000378:metabolism; D006041:Goats / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000097:blood; D007328:Insulin / Q000097:blood; D007662:Ketosis / Q000139:chemically induced* / Q000378:metabolism / Q000662:veterinary; D007774:Lactation / Q000378:metabolism*; D011247:Pregnancy; D012417:Rumen; D014280:Triglycerides / Q000494:pharmacology*
D001786:Blood Glucose; D002072:Butylene Glycols; D006885:Hydroxybutyrates; D007328:Insulin; D014280:Triglycerides; C028491:1,3-butylene glycol; C005830:tributyrin; D020155:3-Hydroxybutyric Acid