title: Plant antimutagenic agents, 7. Structure and antimutagenic properties of cymobarbatol and 4-isocymobarbatol, new cymopols from green alga (Cymopolia barbata).
abstract: Two new compounds, cymobarbatol and 4-isocymobarbatol, were isolated from the marine alga Cymopolia barbata. The complete structures and absolute stereochemistries of these compounds were elucidated by a variety of spectroscopic techniques and X-ray crystallography. Both compounds were found to be nontoxic over a broad concentration range to Salmonella typhimurium strains T-98 and T-100. Both compounds exhibited strong inhibition of the mutagenicity of 2-aminoanthracene and ethyl methanesulfonate toward, respectively, the T-98 strain plus a metabolic activator and T-100.
authors.affiliation: Research Triangle Institute, Research Triangle Park, North Carolina 27709.
authors.forename: M E
authors.initials: ME
authors.lastname: Wall
authors.forename: M C
authors.initials: MC
authors.lastname: Wani
authors.forename: G
authors.initials: G
authors.lastname: Manikumar
authors.forename: H
authors.initials: H
authors.lastname: Taylor
authors.forename: T J
authors.initials: TJ
authors.lastname: Hughes
authors.forename: K
authors.initials: K
authors.lastname: Gaetano
authors.forename: H W
authors.initials: HW
authors.lastname: Gerwick
authors.forename: A T
authors.initials: AT
authors.lastname: McPhail
authors.forename: D R
authors.initials: DR
authors.lastname: McPhail
mesh_terms: D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology*; D000460:Chlorophyta / Q000032:analysis*; D008958:Models, Molecular; D015394:Molecular Structure; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D001578:Benzopyrans; C062201:cymobarbatol