Primary intracerebral lymphoma in systemic lupus erythematosus treated with immunosuppressives.
A 38-year-old woman suffering from systemic lupus erythematosus was treated with cyclophosphamide and prednisone. Two months later she developed mononeuritis multiplex. After one year, she showed a personality change with aggressiveness and paranoid delusions. Grand mal epileptic fits began to occur. An unenhanced CT-scan showed extensive and bilateral frontal hypodense lesions originally ascribed to vasculitis-caused infarcts. On autopsy, a primary intracerebral lymphoma with extensive necroses was demonstrated. The relationship between SLE, immunosuppressive treatment and primary intracerebral lymphoma is discussed.
Cras
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Laboratory of Neuropathology, Born-Bunge Foundation, University of Antwerp, Wilrijk, Belgium.
Franckx
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C
Martin
J J
JJ
D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D008775:Methylprednisolone / Q000627:therapeutic use*; D009336:Necrosis; D014057:Tomography, X-Ray Computed
D003520:Cyclophosphamide; D008775:Methylprednisolone