title: Alterations produced by sertaconazole on the morphology and ultrastructure of Candida albicans.
abstract: We studied the changes produced in Candida albicans yeast cells after treatment in vitro with sertaconazole, with light microscopy, transmission and scanning electron microscopy. Four different concentrations were evaluated (10(-6) M, 10(-5) M, 10(-4) M, 10(-3) M) and two times of action (12 and 17 h) for each concentration. This new antimycotic agent shows a considerable destructive effect in C. albicans cells. The alterations produced by sertaconazole were already manifested after 12 h at the concentration of 10(-6) M and a strong fungicidal activity recorded at 10(-4) M.
authors.forename: J
authors.initials: J
authors.lastname: Guarro
authors.forename: M J
authors.initials: MJ
authors.lastname: Figueras
authors.forename: J
authors.initials: J
authors.lastname: Cano
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000648:ultrastructure; D007093:Imidazoles / Q000494:pharmacology*; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D013876:Thiophenes; C061131:sertaconazole