title: Detection of high-risk groups and individuals for periodontal diseases: laboratory markers from analysis of saliva.
abstract: The use of saliva as a source of components that may identify subjects at risk of developing destructive periodontitis, or provide markers of disease potential or activity, has been reviewed. It was concluded that bacteria, their constituents or products are unlikely to be rewarding and that host-derived salivary factors such as enzymes cannot identify risk, as deficiency states for these do not exist. Secretory IgA, plasma IgA and IgG isotype levels and specific antibodies may be associated with risk, but probably only if levels fall below those which are protective or a specific antibody response is absent. More work is needed to distinguish between monomeric and dimeric IgA antibodies and to identify IgG antibodies in longitudinal clinical studies. In general, although saliva may prove to be useful as a source of indicators of current disease activity or as a means of assessing responses to treatment, it is unlikely to provide evidence for the existence of risk factors.
authors.affiliation: Medical Research Council, Dental Research Unit, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Wilton
authors.forename: M A
authors.initials: MA
authors.lastname: Curtis
authors.forename: I R
authors.initials: IR
authors.lastname: Gillett
authors.forename: G S
authors.initials: GS
authors.lastname: Griffiths
authors.forename: M F
authors.initials: MF
authors.lastname: Maiden
authors.forename: J A
authors.initials: JA
authors.lastname: Sterne
authors.forename: D T
authors.initials: DT
authors.lastname: Wilson
authors.forename: N W
authors.initials: NW
authors.lastname: Johnson
mesh_terms: D015415:Biomarkers / Q000032:analysis; D006089:Gram-Negative Anaerobic Bacteria / Q000201:enzymology / Q000302:isolation & purification; D006801:Humans; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes / Q000032:analysis; D008070:Lipopolysaccharides / Q000032:analysis; D008403:Mass Screening; D009504:Neutrophils / Q000032:analysis; D010510:Periodontal Diseases / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology; D012307:Risk Factors; D012463:Saliva / Q000032:analysis* / Q000201:enzymology / Q000382:microbiology
chemical_list: D015415:Biomarkers; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D008070:Lipopolysaccharides