[Role of methylprednisolone pulse therapy of nephroses in children].
Methylprednisolone (MP) pulse therapy (1 g/1.73 m2 x 3) has been used without side effects in 16 children with steroid dependent or resistant nephrosis. MP allowed a complete remission in 6 patients (group I: 37.5%), after a mean duration of 12 days; 2 of them experienced early relapse; the other patients had either a too short or no follow-up. One child was on partial remission (group II: 6%). The other patients were resistant to therapy (group III: 56%); 8 of them had a renal biopsy which showed focal glomerulosclerosis in 6 (75%). The authors point out that the main interest of methylprednisolone pulse therapy is to confirm steroid resistance.
Khiari
M
M
Clinique médicale infantile, hôpital Mustapha, Alger, Algérie.
Oulebsir
A
A
Bensalah
L
L
Keddari
M
M
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007277:Injections, Jet; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D009401:Nephrosis / Q000188:drug therapy*; D013997:Time Factors
D008775:Methylprednisolone
Place des embols de méthylprednisolone dans les néphroses de l'enfant.