Nasal decongestant effect of oxymetazoline in the common cold: an objective dose-response study in 106 patients.
Oxymetazoline has been used as decongesting nosedrops for more than 25 years but so far no objective dose-response study of the drug has been published. In this double-blind clinical trial the decongestant effect on the nasal mucosa by the doses and concentrations traditionally used of oxymetazoline were studied. In 106 men with acute infectious rhinitis, a significant dose-response relationship was found when the decongestant effect was measured objectively by anterior rhinomanometry and subjectively by symptom scores. The concentration and volumes of the drug recommended from clinical experience seem to be adequate.
Akerlund
A
A
Department of Otorinolaryngology, Central Hospital, Sköevde, Sweden.
Klint
T
T
Olén
L
L
Rundcrantz
H
H
D000328:Adult; D002986:Clinical Trials as Topic; D003139:Common Cold / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D008297:Male; D010109:Oxymetazoline / Q000008:administration & dosage* / Q000627:therapeutic use; D011897:Random Allocation
D007093:Imidazoles; D010109:Oxymetazoline