title: The effect of perinatal 60Co gamma radiation on brain weight in beagles.
abstract: Beagle dogs were given single, whole-body 60Co gamma-radiation exposures at one of three prenatal (8, 28, or 55 days postcoitus) or three postnatal (2, 70, or 365 days postpartum) ages to evaluate the relative radiosensitivity of various stages of brain development. A total of 387 dogs received mean doses ranging from 0.16 to 3.83 Gy, and 120 dogs were sham-irradiated. Groups of dogs were sacrificed at preselected times from 70 days to 11 years of age. Brain weight decreased significantly with increasing dose in dogs irradiated at 28 or 55 days postcoitus or at 2 days postpartum. Irradiations at 28 days postcoitus were dramatically more effective in causing a reduction in brain weight than those at 55 days postcoitus or 2 days postpartum. Among dogs given 1.0 Gy or more and followed for up to 4 years, there was a radiation effect evident at all three sensitive exposure ages. Among dogs given lower doses and followed for up to 11 years, there was a significant decrease in brain weight in dogs given 0.80-0.88 Gy at 28 days postcoitus. All decreases in brain weight were present after normalization for radiation-induced reductions in skeletal (body) size. No specific morphologic changes were noted in the brains which showed the radiation-related reductions in size.
authors.affiliation: Collaborative Radiological Health Laboratory, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
authors.forename: B F
authors.initials: BF
authors.lastname: Hamilton
authors.forename: S A
authors.initials: SA
authors.lastname: Benjamin
authors.forename: G M
authors.initials: GM
authors.lastname: Angleton
authors.forename: A C
authors.initials: AC
authors.lastname: Lee
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000528:radiation effects*; D003037:Cobalt Radioisotopes; D004285:Dogs; D005260:Female; D005720:Gamma Rays; D008297:Male; D009929:Organ Size / Q000528:radiation effects; D011247:Pregnancy; D011836:Radiation Tolerance; D014916:Whole-Body Irradiation
chemical_list: D003037:Cobalt Radioisotopes