title: Immunohistochemical detection of the c-erbB-2 proto-oncogene product in normal, benign and malignant cartilage tissues.
abstract: Benign and malignant cartilage tumours as well as normal cartilage were stained immunohistochemically with antibodies raised to a synthetic peptide from the sequence of the c-erbB-2 protein. Positive staining was present in 18/23 of the chondrosarcomas and in one case of osteochondroma. Normal and benign neoplastic cartilage tissues revealed negative results. It is concluded that expression of the c-erbB-2 protein may contribute to cell transformation in chondrosarcomas; it is not apparent whether the expression of c-erbB-2 protein in chondrosarcomas characterizes a subpopulation of different prognostic significance.
authors.affiliation: Department of Pathology and Orthopedic Clinic, University of Vienna, Austria.
authors.forename: F
authors.initials: F
authors.lastname: Wrba
authors.forename: W J
authors.initials: WJ
authors.lastname: Gullick
authors.forename: H
authors.initials: H
authors.lastname: Fertl
authors.forename: G
authors.initials: G
authors.lastname: Amann
authors.forename: M
authors.initials: M
authors.lastname: Salzer-Kuntschik
mesh_terms: D002356:Cartilage / Q000276:immunology*; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D002804:Chondroblastoma / Q000175:diagnosis / Q000378:metabolism; D002812:Chondroma / Q000175:diagnosis / Q000378:metabolism; D002813:Chondrosarcoma / Q000175:diagnosis / Q000378:metabolism; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D009372:Neoplasms, Connective Tissue / Q000175:diagnosis / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000032:analysis* / Q000276:immunology
chemical_list: D011518:Proto-Oncogene Proteins