[Evaluation of the effect of a new polyfungin derivative in chronic infection of albino mice with P-32 labeled Candida albicans].
White mice, Balb/c, were infected intraperitoneally with Candida albicans strains: standard ATCC 1023 and 910 strain isolated from vaginal excretions of patient suffering from genital mycosis. One group of animals was given new Polish polyene antibiotic N-methylglucamine salt of N-glucosylpolyfungin (N-MGP). It was possible to follow a course of infection using our own experimental model of candidiasis with 32P-Candida albicans cell suspension by measuring a degree of radioactivity of organs taken from treated and untreated animals. Statistically significant lower radioactivity values (P less than 0.01) were found in organs of animals treated with N-MGP salt for 20 days in daily dose of 20 mg/kg of body weight. Therapeutic efficacy of N-MGP salt was confirmed in separate experiments where mice were infected intraperitoneally with unlabelled Candida albicans cells. Negative results of mycological examinations were found when several organs homogenates of treated mice were tested. Activity of new polifungin derivative in chronic candidiasis of mice was found using two different ways of evaluation of this new preparation.
Kurnatowska
A
A
Brykalski
D
D
Kowszyk-Gindifer
Z
Z
Kwaśniewska
J
J
Rózga
A
A
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000528:radiation effects; D002177:Candidiasis / Q000188:drug therapy*; D002908:Chronic Disease; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010538:Peritonitis / Q000188:drug therapy*; D010761:Phosphorus Radioisotopes; D011090:Polyenes / Q000627:therapeutic use
D000935:Antifungal Agents; D010761:Phosphorus Radioisotopes; D011090:Polyenes; C003006:polyfungin; C047476:N-glucosylpolyfungin
Próba oceny działania nowej pochodnej polifunginy w przewlekłym zarazeniu białej myszy Candida albicans znakowanej 32P.