title: Problems associated with the use of immediately dangerous to life and health (IDLH) values for estimating the hazard of accidental chemical releases.
abstract: The possibility of accidental industrial chemical releases has generated considerable recent attention. One area requiring research for emergency planning is the development of safe exposure concentrations for the public in the event of an inadvertent release. The United States Environmental Protection Agency (EPA) has established a list of extremely hazardous substances and suggested that the toxicity ranking for 92 hazardous materials could be based on the "immediately dangerous to life or health" (IDLH) values developed by the National Institute for Occupational Safety and Health (NIOSH) and the Occupational Safety and Health Administration (OSHA). Eighty-four compounds with IDLH values for which published toxicologic data were available were reviewed to assess the appropriateness of applying such values to accidental release situations. When compared with 30-min animal median lethal concentrations (LC50s), 18 of the IDLHs reviewed were in the same range as lethal levels for animals. For 45 compounds the IDLH values were comparable to concentrations producing severe toxic effects (specifically, unconsciousness, incapacitation, or intolerable irritation). Where available, emergency planning guidelines for the military were compared to IDLHs, and in all 31 cases, the IDLHs exceeded the military exposure guidelines. Twenty compounds also were found to pose a potential cancer risk according to common regulatory guidelines, even under the assumption of a single, 30-min exposure at the IDLH concentration. In addition, the high degree of variability (four orders of magnitude) in the relationship of IDLH values to outcomes of lethality or severe toxicity suggests that the use of IDLH values as emergency planning guidelines for accidental releases is questionable.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Hazard Evaluation Section, California Department of Health Services, Berkeley 94704.
authors.forename: G V
authors.initials: GV
authors.lastname: Alexeeff
authors.forename: M J
authors.initials: MJ
authors.lastname: Lipsett
authors.forename: K W
authors.initials: KW
authors.lastname: Kizer
mesh_terms: D000062:Accidents, Occupational / Q000331:legislation & jurisprudence*; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity; D004189:Disaster Planning / Q000331:legislation & jurisprudence*; D015386:Hazardous Substances / Q000506:poisoning*; D006801:Humans; D008452:Maximum Allowable Concentration
chemical_list: D002273:Carcinogens; D015386:Hazardous Substances