title: [Bactericidal effect of cefotaxime-sulbactam and imipenem combined with gentamicin and/or ciprofloxacin against CTX-1 producing Klebsiella pneumoniae].
abstract: Bactericidal activity of gentamicin, imipenem, ciprofloxacin and cefotaxime associated with sulbactam are studied on 36 beta lactamase CTX-1 (TEM-3) producing Klebsiella pneumoniae strains isolated of sputum samples and urines, among patients of intensive care units, in Rangueil hospital (Toulouse). Gentamicin, imipenem, cefotaxime associated with sulbactam have a bactericidal activity at serum levels, obtained with usual therapeutic doses. Ciprofloxacin has a bactericidal activity at concentrations obtained in urine and into lung tissue. Killing curve method was used to study bactericidal activity of these antibiotics alone and in combination, on a representative sample. Alone gentamicin showed the most rapid bactericidal activity (2 hours). The associations with gentamicin are also rapidly bactericidal. The associations with ciprofloxacin and imipenem, ciprofloxacin and cefotaxime/sulbactam are synergistic.
authors.affiliation: Laboratoire de Bactériologie-Virologie, Toulouse.
authors.forename: M
authors.initials: M
authors.lastname: Archambaud
authors.forename: E
authors.initials: E
authors.lastname: Labau
authors.forename: D
authors.initials: D
authors.lastname: Clave
authors.forename: C
authors.initials: C
authors.lastname: Suc
mesh_terms: D002439:Cefotaxime / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000494:pharmacology*; D015378:Imipenem / Q000494:pharmacology*; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D013407:Sulbactam / Q000494:pharmacology*
chemical_list: D005839:Gentamicins; D002939:Ciprofloxacin; D015378:Imipenem; D002439:Cefotaxime; D013407:Sulbactam
vernacular_title: Activité bactéricide de céfotaxime-sulbactam et imipénème associés à gentamicine et/ou ciprofloxacine sur Klebsiella pneumoniae, produisant CTX-1.