The nucleotide sequence of a mouse renin-encoding gene, Ren-1d, and its upstream region.
The renin-encoding genes have been cloned from high (Ren-1d, Ren-2d)- and low (Ren-1c)-renin-producing strains of mice (DBA/2J and C57BL/10). Each of the genes is approx. 9.6 kb in length and consists of nine exons and eight introns. The entire nucleotide sequence of the Ren-1d gene has been determined and the 5'-flanking regions of the three genes, Ren-1c, Ren-1d and Ren-2d, have been compared. The significance of several potential regulatory signals found in the DNA is discussed.
Burt
D W
DW
Department of Biochemistry, University of Leicester, U.K.
Mullins
L J
LJ
George
H
H
Smith
G
G
Brooks
J
J
Pioli
D
D
Brammar
W J
WJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005091:Exons; D005796:Genes; D005809:Genes, Regulator; D007438:Introns; D008099:Liver / Q000201:enzymology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008969:Molecular Sequence Data; D012326:RNA Splicing; D012083:Renin / Q000235:genetics*; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D012984:Software; D013045:Species Specificity
D004247:DNA; D012083:Renin