The cell biology of the insulin receptor.
Following initial binding to specific cell surface receptors insulin is internalized in target cells. The fate of the internalized insulin-receptor complexes and how the processes involved are regulated is reviewed. The implications of these events in the effects of insulin on its target cells and in the physiopathology of diabetes and insulin resistance states are also considered.
Carpentier
J L
JL
Institute of Histology and Embryology, University of Geneva, Switzerland.
D000818:Animals; D003920:Diabetes Mellitus / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000502:physiology*; D007333:Insulin Resistance; D008962:Models, Theoretical; D011972:Receptor, Insulin / Q000502:physiology*
D007328:Insulin; D011972:Receptor, Insulin