title: Mutagenic action of heavy ions on Escherichia coli cells.
abstract: Induction of direct mutations in the lactose operon of E. coli cells by gamma-radiation and accelerated heavy ions with different LET was studied. The experiments were performed with the wild-type PolA and LexA strains. A quadratic dependence of the mutation rate on the dose of different radiations for the wild-type strain and the PolA mutant was observed. However, different types of radiation showed different relative genetic effectivenesses (RGE). The dependence of RGE on LET for the wild-type and PolA strain has a maximum. A LexA strain showed much reduced mutation rates and a linear dose response. The RGE decreased with increasing LET of ionizing radiation.
authors.affiliation: Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Moscow, U.S.S.R.
authors.forename: B
authors.initials: B
authors.lastname: Tokarova
authors.forename: K G
authors.initials: KG
authors.lastname: Amirtayev
authors.forename: S
authors.initials: S
authors.lastname: Kozubek
authors.forename: E A
authors.initials: EA
authors.lastname: Krasavin
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D004256:DNA Polymerase I / Q000235:genetics; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D004735:Energy Transfer; D004926:Escherichia coli / Q000235:genetics; D005720:Gamma Rays; D007763:Lac Operon; D009154:Mutation; D012697:Serine Endopeptidases; D000099160:LexA Repressor Protein
chemical_list: D001426:Bacterial Proteins; D004256:DNA Polymerase I; D012697:Serine Endopeptidases; D000099160:LexA Repressor Protein