Granulomatous eruption after BCG vaccine immunotherapy for malignant melanoma.
In a patient receiving intralesional bacille Calmette-Guérin vaccine injections for recurrent cutaneous metastases of malignant melanoma of the right leg, a striking eruption developed on that limb only. The eruption consisted of multiple 1 to 2 mm, reddish brown, flat-topped papules, with confluence into plaques. Histopathologic examination showed multiple tuberculoid granulomas within the papillary and reticular dermis; special stains and cultures were negative for mycobacteria.
Shea
C R
CR
Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston 02114.
Imber
M J
MJ
Cropley
T G
TG
Cosimi
A B
AB
Sober
A J
AJ
D001500:BCG Vaccine / Q000009:adverse effects*; D005260:Female; D006099:Granuloma / Q000209:etiology*; D006801:Humans; D007868:Leg Dermatoses / Q000209:etiology*; D008545:Melanoma / Q000628:therapy*; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000209:etiology*; D009165:Mycobacterium Infections, Nontuberculous / Q000209:etiology*; D012878:Skin Neoplasms / Q000628:therapy*
D001500:BCG Vaccine