title: [A new drug sulfaton in the combined treatment of infections with sulfanilamide derivatives and diaminopyrimidine].
abstract: Derivatives of diaminopyrimidine as potentiators of the effect of the derivatives of sulfanilamide and other antibacterial drugs are discussed. Experimental data on sulfation, a new combined preparation, based on sulfamonomethoxine (a sulfanilamide derivative) and trimethoprim (a diaminopyrimidine derivative) are presented. Brief clinical characteristics of sulfation, its administration routes, doses, dosage advantages and better tolerance as compared to co-trimethoxazole+ (biseptol) are described.
authors.forename: E N
authors.initials: EN
authors.lastname: Padeĭskaia
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents; D001424:Bacterial Infections / Q000188:drug therapy*; D055598:Chemical Phenomena; D002621:Chemistry; D002986:Clinical Trials as Topic; D004338:Drug Combinations / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006801:Humans; D051379:Mice; D011743:Pyrimidines / Q000008:administration & dosage*; D013422:Sulfamonomethoxine / Q000008:administration & dosage* / Q000627:therapeutic use*; D000077145:Sulfanilamide; D013424:Sulfanilamides / Q000008:administration & dosage* / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage* / Q000627:therapeutic use*
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations; D011743:Pyrimidines; D013424:Sulfanilamides; C017205:2,4-diaminopyrimidine; D000077145:Sulfanilamide; C062251:sulfaton; D014295:Trimethoprim; D013422:Sulfamonomethoxine
vernacular_title: Novyĭ preparat su'lfaton v kombinirovannoĭ terapii infektsiĭ proizvodnymi su'lfanilamida i diaminopirimidina.