[The effect of oxygen deficiency on the stability of the yeast Saccharomyces cerevisiae to the polyenic antibiotic nystatin].
Oxygen deficiency was shown to affect the resistance of different Saccharomyces cerevisiae strains to nystatin, a polyenic antibiotic. This resistance decreased upon oxygen deficiency in the wild-type strains alpha'1 and 7A-P192 as well as in the mutant strains NYS 2, NYS 3 and NYS 4, but remained unchanged in the mutants NYS-1 and NYS 5. The qualitative composition of sterols was studied in the strains with a modified ergosterol synthesis, which were grown under the conditions of oxygen deficiency. Such conditions exerted a considerable effect on the accumulation of intermediate products in ergosterol biosynthesis.
Ekhvalova
T V
TV
Mikhaĭlova
N P
NP
Ogorodnikova
T E
TE
V'iunov
K A
KA
D015687:Cell Hypoxia; D004352:Drug Resistance, Microbial / Q000235:genetics*; D004875:Ergosterol / Q000096:biosynthesis; D005800:Genes, Fungal; D009154:Mutation; D009761:Nystatin / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*
D009761:Nystatin; D004875:Ergosterol
Vliianie defitsita kisloroda na ustoĭchivost' drozhzheĭ Saccharomyces cerevisiae k polienovomu antibiotiku nistatinu.