DNA methylation in aging and cancer.
DNA methylation processes appear to be disturbed in senescing mice and also in some tumor cells. Although it is possible that age-related demethylation of DNA could predispose cells to carcinogenic transformation, present evidence does not favor this hypothesis.
Mays-Hoopes
L L
LL
Biology Department, Occidental College, Los Angeles.
D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology; D004247:DNA / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008745:Methylation
D002273:Carcinogens; D004247:DNA