Genotoxic carcinogenic risk of a new non-tobacco-burning cigarette.
The recent development of a non-tobacco-burning cigarette has led to much controversy. In the present study, we analyzed the DNA-modifying ('genotoxic') potential of the emissions of this 'new' cigarette. Based upon the reported results of short-term tests (mutagenicity, clastogenicity, DNA damage), the 'new' cigarette has a greatly decreased potential for genotoxic carcinogenicity when compared to the 'regular' cigarette. The analysis does not address the possibility of cancer induction by a non-genotoxic or promotional mechanism, nor the cardiovascular and addictive risks of cigarette smoking.
Rosenkranz
H S
HS
Department of Environmental Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.
Ennever
F K
FK
D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens; D004247:DNA / Q000187:drug effects; D004249:DNA Damage; D051381:Rats; D012306:Risk; D012907:Smoking / Q000009:adverse effects*
D002273:Carcinogens; D004247:DNA