[Inhibitory effects of jian pi li qi Chinese medicinal herbs on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in rats].
Chinese medicinal herbs with Jian Pi Li Qi action were tested for their effects in inhibiting the precancerous lesions, gamma-GT positive hepatocellular foci and the expression of oncogenes (N-ras, Ha-ras) in male SD rats. The rats were given one i.p. dose of initiator DEN within 24 hours after 2/3 partial hepatectomy. The livers of sacrificed rats were processed to gamma-GT histochemical staining and measuring of oncogenic expression. The results of these two parameters showed that Chinese medicinal herbs with Jian Pi Li Qi action are effective in inhibiting the precursory lesions of liver cancer in rats.
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D000818:Animals; D004052:Diethylnitrosamine; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005786:Gene Expression Regulation / Q000187:drug effects; D011905:Genes, ras / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D011230:Precancerous Conditions / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
D004365:Drugs, Chinese Herbal; D004052:Diethylnitrosamine