Correlations between acute lymphoid leukemia (ALL) immunophenotype and clinical and laboratory data at presentation. A study of 350 patients.
The phenotypes of malignant cells from 350 untreated patients with acute lymphoblastic leukemia (ALL) were determined at diagnosis with the use of a panel of monoclonal antibodies to leukocyte antigens. According to the phenotypes seen, the cases were divided into five groups, pre-B ALL, B-ALL, T-ALL, MO-ALL, and undifferentiated ALL. Each group was subdivided, resulting in 11 defined immunologic subtypes. Correlations between clinical and laboratory features were investigated at presentation. ALL of early-B phenotype associated with elevated cell counts occurred more often in female and infant patients than in male patients. Involvement of the central nervous system was frequent in B-ALL, which occurred mostly in male patients. A male prevalence was also seen in ALL of T-lineage in which significant differences regarding clinical characteristics and leukocyte counts appeared among the four subtypes. The clinical relevance of phenotypic subcategorization is supported by our observations.
Garand
R
R
Laboratoire Hématologie, CHR Nantes, France.
Vannier
J P
JP
Bene
M C
MC
Faure
G C
GC
Bernard
A
A
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology; D008297:Male; D015337:Multicenter Studies as Topic; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification* / Q000276:immunology / Q000473:pathology; D011379:Prognosis
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor