[Inhibition of free-radical lipid oxidation in the mechanisms of immediate and long-term adaptation to stress].
The literary data and own results concerning the stages of free radical lipid oxidation inhibition during the adaptation of animals to stress are reviewed. Using the chronic stress models such as immobilization, experimental neurosis, it has been shown, that in general adaptation syndrome the stage of permanent adaptation to stress corresponds to a permanent inhibition of free radical processes in animal tissues. This stage is accompanied by the activation of superoxide radical scavenging and corresponding changes of lipid composition. similar results are obtained on the model of the development of permanent compensation processes after brain injury. Studying the acute stress it has been found, that during first minutes the inhibition of lipid peroxidation which precedes its further activation takes place. This stage corresponds to the realization of urgent adaptation phase to stress. The role of inhibition of free radical processes in mechanisms of urgent and permanent adaptation to stress is under discussion.
Guliaeva
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NV
D000222:Adaptation, Physiological; D000818:Animals; D005609:Free Radicals; D005790:General Adaptation Syndrome / Q000503:physiopathology; D015227:Lipid Peroxidation; D010146:Pain / Q000503:physiopathology; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
D005609:Free Radicals
Ingibirovanie svobodnoradikal'nogo okisleniia lipidov v mekhanizmakh srochnoĭ i dolgovremennoĭ adaptatsii k stressu.