[Effect of the administration of hepato stimulating substance in acute hepatic insufficiency].
The effect of hepatic stimulator substance (HSS) on liver regeneration was evaluated after 68% partial hepatectomy in the rat by measuring the incorporation of tritiated thymidine into regenerating hepatocytes. Moreover, a liver failure model was established by 98% hepatectomy and different schedules of HSS administration were followed for studying the effect of the substance on the survival of the treated rats. A 40% survival was observed one week after hepatectomy, in the group of rats administered with the highest dosage of HSS (n = 10), as compared to a survival value of 13% in the control group (n = 15). Thus, hepatotrophic and hepatostimulating substances contained in HSS, could play a therapeutic role in experimental, and possibly clinical, acute liver failure.
Gorini
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P
D000818:Animals; D004353:Drug Evaluation, Preclinical; D006498:Hepatectomy; D015850:Interleukin-6; D008107:Liver Diseases / Q000188:drug therapy* / Q000401:mortality; D008115:Liver Regeneration / Q000187:drug effects*; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew
D015850:Interleukin-6; D011506:Proteins
Effetto della somministrazione di sostanza epatostimolante (HSS) in corso di insufficienza epatica acuta.