Altered gene expression in Alzheimer's disease brain tissue.
We review the evidence for altered gene expression in Alzheimer's disease brain and identify alternative molecular approaches for isolating additional novel markers. One marker, pADHC-9, was isolated from a human hippocampal cDNA library by differential screening with AD and control cDNA probes. This clone hybridizes to a 2 Kb RNA which is increased 2 fold in AD hippocampus. The deduced amino acid sequence of pADHC-9 codes for a 52 kDAL protein similar to a testicular sulfated glycoprotein secreted by rat Sertoli cells. The normal function of this protein in brain and whether that function is altered in Alzheimer's disease is unknown.
May
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Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191.
Johnson
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Poirier
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Lampert-Etchells
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Finch
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D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism; D000941:Antigens / Q000235:genetics* / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D005786:Gene Expression Regulation; D006023:Glycoproteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans
C056167:Alzheimer's disease antigen; D000941:Antigens; D006023:Glycoproteins