[Loss of beta 2 microglobulin from the surface of "dysplastic" and malignant epithelial cells of the uterine cervix].
We studied 75 cervical biopsies (39 cases with CIN I-III and 36 with invasive squamous carcinoma differentiated to various degrees) immunohistochemically to determine the beta 2-m content of the epithelial cells. In cells having CIN we found a clear decrease in beta 2-m with a statistically significant correlation to the degrees of severity of the lesion. All of the invasive carcinomas showed a complete absence of beta 2-m. This finding should be evaluated within the framework of an immunological dedifferentiation, and it supports the views regarding the neoplastic nature of cervical dysplasia. The demonstration of beta 2-m in atypical epithelial cells of the cervix is a possible indication for the intraepithelial localisation of the lesion.
Tseleni-Balafouta
S
S
Pathologischen Institut, Universität Athen.
Balafoutas
A C
AC
Paraskevakou
H
H
D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002584:Cervix Uteri / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011230:Precancerous Conditions / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D001613:beta 2-Microglobulin / Q000032:analysis*
D001613:beta 2-Microglobulin
Verlust von beta 2-Mikroglobulin aus der Oberfläche "dysplastischer" und maligner Epithelzellen der Cervix uteri.