Transfer of low level trimethoprim resistance in faecal isolates obtained from apparently healthy Nigerian students.
Twenty-four of 63 enteric Gram-negative organisms (38.1%) which were isolated from 35 apparently healthy Nigerian students were found to have low trimethoprim resistance (MIC less than 1000 mg/l). These isolates were also found to be resistant to several other antibiotics and trimethoprim resistance was found to be transferable from 15 (62.5%) of the trimethoprim resistant organisms into E. coli EC 1005. It is likely that the high percentage of trimethoprim resistance encountered in this study is related to the high rate of resistance transfer which was observed.
Lamikanra
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Department of Pharmaceutics, Obafemi Awolowo University, Ile-Ife, Nigeria.
Fayinka
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Olusanya
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D000328:Adult; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D005243:Feces / Q000382:microbiology*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D009549:Nigeria; D011815:R Factors; D014296:Trimethoprim Resistance / Q000235:genetics*