Splenopentin (DAc SP-5)-accelerated reconstitution of antibody formation after syngeneic bone marrow transplantation.
Sublethally irradiated AB/Bln, mice (800 c Gy) and supplemented with syngeneic bone marrow cells were treated with or without a splenopentin derivative (DAc SP-5) and compared for their capacity to produce antibodies. In bone marrow cell plus DAc SP-5 treated animals antibody forming cells were found earlier and in a higher frequency than in mice treated with bone marrow cells only. These findings demonstrate that DAc SP-5 is able to induce bone marrow cell maturation.
Eckert
R
R
Institute of Medical Immunology, Medical School (Charité), Humboldt University, Berlin, GDR.
Diezel
W
W
Schmidt
R
R
Forner
K
K
Volk
H D
HD
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D016026:Bone Marrow Transplantation / Q000276:immunology*; D005260:Female; D007075:Immunoglobulin M / Q000096:biosynthesis; D051379:Mice; D008815:Mice, Inbred Strains; D010446:Peptide Fragments / Q000494:pharmacology*; D013946:Thymopoietins / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D007075:Immunoglobulin M; D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; C041898:splenopentin