Comparison of hydroxypropyl methylcellulose 2% (Adatocel) and hyaluronic acid 1% (Healon).
Hydroxypropyl methylcellulose solutions (2% HPMC) were examined for impurities. There was no evidence of any particulate matter in two solutions from different sources: one prepared by a hospital pharmacy, the other industrially prepared (Adatocel). In a controlled clinical study, Adatocel was compared with Healon (1% hyaluronic acid solution). The postoperative irritation (cellular response) in the anterior chamber was the same in both groups.
Fechner
P U
PU
Department of Ophthalmology, Robert Koch Hospital, Hannover-Gehrden, West Germany.
Rimpler
M
M
D000368:Aged; D000369:Aged, 80 and over; D000596:Amino Acids / Q000032:analysis; D000867:Anterior Chamber / Q000187:drug effects*; D002387:Cataract Extraction; D002986:Clinical Trials as Topic; D004340:Drug Contamination; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects / Q000032:analysis / Q000494:pharmacology*; D065347:Hypromellose Derivatives; D007910:Lenses, Intraocular; D008297:Male; D008747:Methylcellulose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000032:analysis / Q000494:pharmacology; D008875:Middle Aged; D011446:Prospective Studies; D011897:Random Allocation
D000596:Amino Acids; D065347:Hypromellose Derivatives; D006820:Hyaluronic Acid; D008747:Methylcellulose