Failure of in vitro ethanol to inhibit LHRH release from the hypothalamus.
The reproductive alterations induced by ethanol (ETOH) in the male rodent have been intensively investigated. Although gonadal effects are well characterized, the impact of ETOH on the hypothalamic peptide luteinizing hormone-releasing hormone (LHRH) has been less well defined. The releasability of hypothalamic LHRH in the presence of ETOH has not been directly studied. We report here that ETOH in concentrations of 50 mg% to 400 mg% failed to inhibit LHRH release in vitro.
Emanuele
M A
MA
Research and Medical Services, Veterans Administration Hospital, Hines, IL 60141.
Tentler
J
J
Reda
D
D
Kirsteins
L
L
Emanuele
N V
NV
Lawrence
A M
AM
D000818:Animals; D002478:Cells, Cultured; D000431:Ethanol / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D007987:Gonadotropin-Releasing Hormone; D000431:Ethanol; D011188:Potassium