Clinical assessment and performance tasks in depression: a comparison of amitriptyline and trazodone.
Depression, anxiety and psychomotor performance were assessed in 20 depressed patients during double-blind treatment with amitriptyline or trazodone. There was no difference in onset of antidepressant or anxiolytic action. No decrement or improvement on computerised tasks was found. Dry mouth was significantly more frequent and severe with amitriptyline.
Botros
W A
WA
St. Mary's Hospital Medical School, London.
Ankier
S I
SI
Priest
R G
RG
McManus
I C
IC
Steinert
J
J
Samir
Z Y
ZY
D000293:Adolescent; D000328:Adult; D000368:Aged; D000639:Amitriptyline / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011340:Problem Solving / Q000187:drug effects*; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000187:drug effects*; D016032:Randomized Controlled Trials as Topic; D011930:Reaction Time / Q000187:drug effects*; D014196:Trazodone / Q000627:therapeutic use*
D000639:Amitriptyline; D014196:Trazodone