CSF-1 induces resorption of embryos in mice.
We have shown previously that C57BL/6J female mice inoculated with the syngeneic BL6-T2 regressor tumor resorb a high proportion of embryos sired by B6D2F1 or DBA/2 males but not embryos engendered by CBA/J or C57BL/6J males. In this present report, we provide a mechanism elucidating the nature of the fetal wastage observed. It was found that the BL6-T2 tumor secretes constitutively GM-CSF and CSF-1. Based on the hypothesis that those cytokines could interfere with normal fetal development, we injected semi-purified GM-CSF or CSF-1 into pregnant females, for five days. Results show that CSF-1 was able to induce a high rate of fetal resorption whereas GM-CSF had no effect.
Tartakovsky
B
B
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
D000019:Abortifacient Agents; D000818:Animals; D003115:Colony-Stimulating Factors / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D005327:Fetal Resorption / Q000139:chemically induced*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000378:metabolism / Q000494:pharmacology; D016173:Macrophage Colony-Stimulating Factor; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000378:metabolism; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000503:physiopathology
D000019:Abortifacient Agents; D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016173:Macrophage Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor