Ceftriaxone-netilmicin combination in single-daily-dose treatment of experimental Escherichia coli endocarditis.
We evaluated the activities of ceftriaxone (15 mg/kg), netilmicin (6 mg/kg), and their combination given intramuscularly once daily for 4 days for the treatment of experimental Escherichia coli endocarditis in rabbits. In vitro, a greater rate of killing and an increased trough serum bactericidal titer (P less than 0.01) were achieved with the combination. In vivo, the combination had a greater bactericidal effect (P less than 0.01) and resulted in a greater number of sterile vegetations (P less than 0.05) than single-drug therapy. Thus, in vivo, an increased effect can be obtained despite a single daily dose of a long-acting cephalosporin and an aminoglycoside.
Fantin
B
B
Institut National de la Santé et de la Recherche Médicale U.13, Hôpital Claude Bernard, Université Paris VII, France.
Pangon
B
B
Potel
G
G
Vallois
J M
JM
Caron
F
F
Bure
A
A
Carbon
C
C
D000818:Animals; D002443:Ceftriaxone / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004338:Drug Combinations; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D009428:Netilmicin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011817:Rabbits
D004338:Drug Combinations; D009428:Netilmicin; D002443:Ceftriaxone