Inhibition by acetylsalicylate of the hyperglycemic response induced in mice by sodium nitroprusside.
The injection of sodium nitroprusside (SNP) into mice induced a hyperglycemic response which was reduced by pretreatment with acetylsalicylate (ASA). The activity of glutamate dehydrogenase was significantly increased in islets from pancreases removed after SNP injection. This effect was prevented by pretreatment with ASA. Isolated mouse islets incubated with SNP exhibited stimulated activity of glutamate dehydrogenase both in the presence of low and high glucose concentrations, whereas the release of insulin was stimulated at low but inhibited at high glucose concentrations. These changes were abolished in the additional presence of ASA. The findings indicate that the hyperglycemic action of SNP may be related to changes in the generation of cyclooxygenase products.
Boquist
L
L
Institute of Parthology, University of Umeå, Sweden.
D000818:Animals; D001241:Aspirin / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D005260:Female; D005292:Ferricyanides; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D006943:Hyperglycemia / Q000139:chemically induced / Q000517:prevention & control*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000201:enzymology; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009599:Nitroprusside
D001786:Blood Glucose; D005292:Ferricyanides; D007328:Insulin; D009599:Nitroprusside; D005969:Glutamate Dehydrogenase; D001241:Aspirin