title: [Preventive use of single dose antibiotics in acute appendicitis. Results of a prospective randomized clinical study].
abstract: A prospective randomized clinical trial was performed to determine the efficiency of single-dose antibiotic prophylaxis in preventing septic complications after appendectomy. The infection rate increased significantly in the control group without antibiotic prophylaxis (9.3% to 20.3%). Older patients with severe appendicitis had more advantages from the prophylaxis than younger ones. We have suggested to perform antibiotic prophylaxis individually only in those patients with high risk of septic complications after appendectomy.
authors.affiliation: Klinik für Chirurgie, Medizinischen Akademie Magdeburg.
authors.forename: H G
authors.initials: HG
authors.lastname: Birkigt
authors.forename: H
authors.initials: H
authors.lastname: Beyer
authors.forename: U
authors.initials: U
authors.lastname: Schmidt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000008:administration & dosage*; D001062:Appendectomy; D001064:Appendicitis / Q000601:surgery*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D011292:Premedication; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D008795:Metronidazole; D000667:Ampicillin
vernacular_title: Single-dose-Antibiotikaprophylaxe bei akuter Appendizitis. Ergebnisse einer prospektiven randomisierten klinischen Studie.