Comparison of intraoperative versus 24 hour antibiotic prophylaxis in total joint replacement. A controlled prospective study.
One hundred and ninety-six consecutive total joint recipients, including unilateral and bilateral procedures, were studied. Patients were randomly assigned to receive one of two prophylactic protocols. Group A (98 patients) received two intraoperative doses of cefuroxime (1500 mg and 750 mg) intravenously and continued cefuroxime for 24 hours postoperatively (750 mg every eight hours intravenous piggy back). Group B (98 patients) received two intraoperative intravenous doses of cefuroxime (1500 mg and 750 mg) and no postoperative doses. The opening or closing surgical culture was positive for five patients in Group A and 10 patients in Group B. None of these patients had a postoperative infection. Patients were followed for a minimum of one year after surgery. No deep wound infection was reported for either group.
Ritter
M A
MA
Center for Hip and Knee Surgery, Mooresville, Indiana.
Campbell
E
E
Keating
E M
EM
Faris
P M
PM
D000293:Adolescent; D000328:Adult; D000368:Aged; D002444:Cefuroxime / Q000008:administration & dosage*; D002511:Cephalosporins / Q000008:administration & dosage*; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007262:Infusions, Intravenous; D007430:Intraoperative Care / Q000379:methods*; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods*; D011446:Prospective Studies; D011897:Random Allocation; D013997:Time Factors
D002511:Cephalosporins; D002444:Cefuroxime