[Selenium levels in erythrocytes of children with celiac disease].
Selenium is the component of the glutationperoxidase one of the most important enzymes in the antioxidant protection of the organism. In preliminary studies the authors found in celiac children increased sensitivity to oxidative stress and biochemical changes referring to decreased activity of glutationperoxidase enzyme. Therefore the selenium content of washed erythrocytes has been determined with fluorimetry in 24 celiac children kept on gluten containing diet and 25 on gluten-free diet. In gluten loading the selenium level was significantly lower than in the healthy control group. The selenium value rose at a small degree in the erythrocytes of celiac children kept on gluten-free diet but did not reach the lower limit of the physiological value. On the basis of these results the malabsorption of selenium was found to play also an important role in the decreased protecting capacity against oxidative stress effects in celiac diseases of childhood. The necessity of supplementing the trace element is raised.
Boda
M
M
Németh
I
I
D002446:Celiac Disease / Q000097:blood / Q000178:diet therapy*; D002675:Child, Preschool; D004912:Erythrocytes / Q000032:analysis; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D012643:Selenium / Q000097:blood*
D005983:Glutens; D012643:Selenium
Coeliakiás gyermekek vörösvértest szelén szintjének vizsgálata.