[Dexfenfluramine and feeding behavior. Clinical and pharmacoclinical studies].
Dexfenfluramine is undoubtedly the most studied molecule in the field of feeding behaviour and it has increased our fundamental knowledge of food intake and body mass regulation. Animal and human studies have shown that dexfenfluramine increases the degree of satiety induced by food intake. Dexfenfluramine seems to act directly on the fundamental mechanisms of energetic regulation. Dexfenfluramine also has an original effect on some food intake disorders. In "carbohydrate cravers", dexfenfluramine reduces total food intake by selectively reducing carbohydrate snacks without reducing protein intake significantly.
Fantino
M
M
Université de Bourgogne, Département de Physiologie, Faculté de Médecine, Dijon.
D000818:Animals; D003863:Depression / Q000209:etiology; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D005277:Fenfluramine / Q000494:pharmacology*; D006801:Humans; D006963:Hyperphagia / Q000503:physiopathology; D008954:Models, Biological; D009765:Obesity / Q000503:physiopathology; D012701:Serotonin / Q000502:physiology
D005277:Fenfluramine; D012701:Serotonin
Dexfenfluramine et comportements alimentaires. Etudes cliniques et pharmacocliniques.