title: Controlled trial of the prophylactic administration of antibiotics in sclerotherapy of esophageal varices.
abstract: The aim of this controlled trial was to determine the usefulness of chemoprophylaxis in sclerotherapy of ruptured esophageal varices. Sixty patients bleeding from esophageal varices, without signs of infection at admission, were included in a randomized open trial of one-year duration. Thirty patients received, along with the usual standard therapy (infusions, transfusions) 4x1 g ampicillin intravenously over 3 days, and 30 patients received the standard therapy only. Bleeding varices of the esophagus were sclerosed transendoscopically intravenously using 1% polidocanol solution. Body temperature, general condition, white blood count, differential blood count and sedimentation rate were followed-up over three days. There were no statistically significant differences between the groups in the mean values of the mentioned parameters. There was no correlation between the dose of sclerosant used and body temperature or leukocyte count. Chemoprophylaxis proved to have no effect in this indication.
authors.affiliation: Clinical Hospital Center, Department of Medicine, Zagreb, Yugoslavia.
authors.forename: R
authors.initials: R
authors.lastname: Pulanić
authors.forename: B
authors.initials: B
authors.lastname: Vrhovac
authors.forename: B
authors.initials: B
authors.lastname: Jereb
authors.forename: N
authors.initials: N
authors.lastname: Jokić
mesh_terms: D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000517:prevention & control; D002986:Clinical Trials as Topic; D004932:Esophageal and Gastric Varices / Q000628:therapy*; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D015911:Sclerotherapy
chemical_list: D000667:Ampicillin