Association of class I major histocompatibility heavy and light chains induced by viral peptides.
We describe a cell in which association of a major histocompatibility complex class I heavy chain with beta 2-microglobulin is induced by a peptide derived from influenza nucleoprotein. Association of antigenic peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with beta 2-microglobulin and transport of the antigen-MHC complex to the cell surface.
Townsend
A
A
Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
Ohlén
C
C
Bastin
J
J
Ljunggren
H G
HG
Foster
L
L
Kärre
K
K
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D002472:Cell Transformation, Viral; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D046911:Macromolecular Substances; D009154:Mutation; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins / Q000276:immunology; D009975:Orthomyxoviridae / Q000235:genetics; D011487:Protein Conformation; D016601:RNA-Binding Proteins; D014758:Viral Core Proteins; D014764:Viral Proteins / Q000276:immunology; D001613:beta 2-Microglobulin / Q000276:immunology / Q000302:isolation & purification
D015395:Histocompatibility Antigens Class I; D046911:Macromolecular Substances; C048842:NP protein, Influenza A virus; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D016601:RNA-Binding Proteins; D014758:Viral Core Proteins; D014764:Viral Proteins; D001613:beta 2-Microglobulin