Decreased essential antioxidants and increased lipid hydroperoxides following high-dose radiochemotherapy.
The blood from 19 patients having bone marrow transplantation was examined for the essential antioxidants alpha-tocopherol and beta-carotene as well as lipid hydroperoxides before, at and after bone marrow transplantation (BMT). Conditioning therapy, preceding BMT in order to achieve marrow ablation and immunosuppression, consists of high-dose chemotherapy which is mostly combined with total body irradiation (TBI). In order to see a possible difference between patients with and without additional TBI, we divided the patients up into two groups; patients receiving TBI (RT+) and patients without TBI (RT-). All patients required total parenteral nutrition beginning one week prior to BMT. After conditioning therapy plasma levels of absolute and lipid-standardized alpha-tocopherol and beta-carotene decreased in both groups, presumably as a result of an enhanced breakdown of these antioxidants. The loss of these lipid-soluble antioxidants has to be considered as a possible cause for early post-transplant toxicity. Lipid hydroperoxides increase significantly in the group of patients with additional TBI, whereas the other group, receiving no additional TBI, showed no significant change. We suggest high-dose supplementation of essential antioxidants for patients undergoing BMT.
Clemens
M R
MR
Eberhard-Karls-Universität Tübingen, Federal Republic of Germany.
Ladner
C
C
Schmidt
H
H
Ehninger
G
G
Einsele
H
H
Bühler
E
E
Waller
H D
HD
Gey
K F
KF
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002338:Carotenoids / Q000097:blood*; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D014810:Vitamin E / Q000097:blood*; D014916:Whole-Body Irradiation; D019207:beta Carotene
D000970:Antineoplastic Agents; D008054:Lipid Peroxides; D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids