Reliability of salt-sensitivity testing in normotensive subjects.
We examined the reliability of dietary salt-sensitivity testing by repeatedly studying the effects of a high (220 mmol/day) and low (20 mmol/day) salt diet in 15 normotensive subjects. Reliability of classification of salt-sensitivity as described by the kappa statistic was 0.87 implying an almost perfect strength of agreement between the two parts of the study. Whereas only 20% of the subjects with negative familial histories of hypertension were salt-sensitive, this was the case with 68% of the subjects with positive familial histories. Our results show that salt-sensitivity can be reliably tested in normotensive subjects and that it is related to a familial history of hypertension.
Sharma
A M
AM
Abteilung für Allgemeine Innere Medizin und Nephrologie, Universitätsklinikum Steglitz, Freie Universität Berlin.
Schattenfroh
S
S
Kribben
A
A
Distler
A
A
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002986:Clinical Trials as Topic; D006801:Humans; D006973:Hypertension / Q000178:diet therapy / Q000235:genetics*; D008297:Male; D011897:Random Allocation; D012307:Risk Factors; D012982:Sodium, Dietary / Q000008:administration & dosage
D012982:Sodium, Dietary