title: Comparison of the effects of continuous intrapleural vs epidural administration of 0.5% bupivacaine on pain, metabolic response and pulmonary function following cholecystectomy.
abstract: Twenty patients undergoing elective cholecystectomy were prospectively randomised to receive either intrapleural (bolus 20 ml followed by 10 ml/h) or thoracic epidural (bolus 9 ml followed by 5 ml/h) bupivacaine 0.5% for 8 h postoperatively to assess the effect of these two techniques on pain, pulmonary function and the surgical stress response. As assessed by the visual analogue scale (VAS), both groups received good but not total pain relief. Both groups had a 50% reduction in forced expiratory volume (FEV1), forced vital capacity (FVC) and peak expiratory flow rate (PEFR) after operation, and there was no observed effect on the stress response as measured by plasma glucose and cortisol. It is concluded that while both techniques provide good analgesia, the degree and extent of nerve blockade are not sufficient to affect the afferent neurogenic stimuli responsible for the observed effects on pulmonary function and the stress response.
authors.affiliation: Department of Surgical Gastroenterology and Anaesthesiology, Hvidovre University Hospital, Copenhagen, Denmark.
authors.forename: N B
authors.initials: NB
authors.lastname: Scott
authors.forename: T
authors.initials: T
authors.lastname: Mogensen
authors.forename: D
authors.initials: D
authors.lastname: Bigler
authors.forename: H
authors.initials: H
authors.lastname: Kehlet
mesh_terms: D000328:Adult; D015360:Analgesia, Epidural; D001786:Blood Glucose / Q000378:metabolism; D002045:Bupivacaine / Q000008:administration & dosage* / Q000009:adverse effects; D002763:Cholecystectomy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012129:Respiratory Function Tests; D013312:Stress, Physiological / Q000097:blood / Q000188:drug therapy*
chemical_list: D001786:Blood Glucose; D009020:Morphine; D006854:Hydrocortisone; D002045:Bupivacaine