[Non-specific vaginitis and topical treatment. Comparison of flunoxaprofen and benzydamine].
The efficacy and tolerability of a new NSAID-flunoxaprofen-have been evaluated in patients suffering from non specific vaginitis, by topical application for 20 days (vaginal washings with water solution of the preparation). The activity of flunoxaprofen has been compared with that of benzidamine with regard to normalization of bacterial vaginal flora, taking into consideration the increase of Döderlein bacillus. A remarkable significant improvement of all the symptoms has been observed in the group of patients treated with flunoxaprofen with respect to that receiving benzidamine; moreover 57.9% of the subjects treated with flunoxaprofen showed a significant increase of Döderlein bacillus while in the benzidamine group the percentage reached a value of 11.8%. Flunoxaprofen may be considered a useful and active tool for the topical treatment of non specific vaginal diseases.
Cecchini
G
G
Ferutta
P
P
Soldà
A
A
Ragazzi
G
G
D000282:Administration, Intravaginal; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000627:therapeutic use; D001583:Benzoxazoles / Q000008:administration & dosage* / Q000627:therapeutic use; D001591:Benzydamine / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007778:Lactobacillus / Q000502:physiology; D008875:Middle Aged; D011720:Pyrazoles / Q000008:administration & dosage*; D014621:Vagina / Q000382:microbiology; D014627:Vaginitis / Q000188:drug therapy* / Q000382:microbiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001583:Benzoxazoles; D011720:Pyrazoles; D001591:Benzydamine; C045356:flunoxaprofen
Vaginiti aspecifiche e trattamento topico. Confronto tra flunoxaprofene e benzidamina.