Structure-activity relationships among mycotoxins.
Relationships between structural features and biological effects of mycotoxins are reviewed. Structure-activity relationships are characterized at the molecular, subcellular, cellular, or supracellular level. Major chemical and physicochemical factors responsible for bioactivity of mycotoxins are stressed. A variety of chemical families of mycotoxins are then discussed from the point of view of structure-activity relationships. The structurally related families comprise small lactones, macrocyclic lactones, isocoumarin derivatives, aflatoxins and related compounds trichothecenes, anthraquinones, indole-derived tremorgens and selected amino acid-derived mycotoxins such as sporidesmins and cyclosporines. Biological effects of mycotoxins include acute and chronic toxicity, antimicrobial activity, mutagenicity and genotoxicity, carcinogenicity and biochemical modes of action.
Betina
V
V
Department of Environmental Chemistry and Technology, Faculty of Chemistry, Slovak Polytechnical University, Bratislava.
D000818:Animals; D002273:Carcinogens; D009153:Mutagens; D009183:Mycotoxins / Q000494:pharmacology / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013723:Teratogens
D002273:Carcinogens; D009153:Mutagens; D009183:Mycotoxins; D013723:Teratogens