title: [Autoimmune syndrome associated with host versus graft reaction in the mouse].
abstract: The neonatal injection of semi-allogeneic spleen cells in mice induces a state of tolerance which can be demonstrated in mixed lymphocyte culture by the inability of T lymphocytes to proliferate, to secrete interleukin-2 and to generate cytolytic activities towards the injected alloantigens. Tolerant animals develop an autoimmune syndrome characterized by an antibody-mediated glomerulonephritis associated with high levels of IgE, IgG1 and anti-DNA antibodies. This syndrome is linked to the activation of B cells injected at birth by host T cells which escape tolerance induction. Interleukin 4 is one of the mediators of these lymphocytic interactions, which suggests that Th2 cells play an important role in this experimental model of autoimmune glomerulonephritis.
authors.affiliation: Département médico-chirurgical de Néphrologie, Université Libre de Bruxelles.
authors.forename: M
authors.initials: M
authors.lastname: Goldman
authors.forename: D
authors.initials: D
authors.lastname: Abramowicz
authors.forename: J M
authors.initials: JM
authors.lastname: Doutrelepont
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology / Q000637:transplantation; D005921:Glomerulonephritis / Q000276:immunology; D006789:Host vs Graft Reaction / Q000276:immunology*; D007108:Immune Tolerance; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology
vernacular_title: Syndrome autoimmun associé à la réaction de l'hôte contre le greffon chez la souris.