title: Chromosomes of malaria parasites.
abstract: The advent of pulsed field gradient electrophoresis has proved remarkably useful for studying chromosomes of the genetically intractable malaria parasite Plasmodium falciparum. Advances include determination of the karyotype, a linkage map and restriction maps of individual chromosomes that enable the ordering of genes. The structural basis underlying a frequently occurring form of chromosome size polymorphism is now understood and other polymorphisms are providing tantalizing clues to the mechanisms underlying drug resistance.
authors.forename: S J
authors.initials: SJ
authors.lastname: Foote
authors.forename: D J
authors.initials: DJ
authors.lastname: Kemp
mesh_terms: D000818:Animals; D002875:Chromosomes; D004351:Drug Resistance / Q000235:genetics; D010963:Plasmodium falciparum / Q000235:genetics*; D011110:Polymorphism, Genetic; D015183:Restriction Mapping