French national bone marrow donor registry and interaction with foreign files.
A program to obtain volunteer bone marrow donors has been developed. A total of 33.000 HLA-A, B typings were performed. A search for 527 patients has been initiated. Among these, 44% are suffering from chronic myelogenous leukemia. For 23% of the patients no HLA-A, B identical donor has been identified. Out of the 401 patients who had HLA-A, B identical donor 35% (139/401) had one or more HLA-A, B, DR identical donors. In one of the transplant center, when the mixed lymphocyte culture (MLR) was carried out between 219 donors and 79 patients, a transplantation for 20/79 patients has been proposed. Up to now, transplantation has been carried out in 31 patients whom donor searches were initiated.
Raffoux
C
C
GMFT, Laboratoire d'Immunologie et d'Histocompatibilité, Hôpital Saint-Louis, Paris, France.
Rabian
C
C
Gluckman
E
E
D016026:Bone Marrow Transplantation; D005060:Europe; D005602:France; D006650:Histocompatibility Testing; D006801:Humans; D007391:International Cooperation; D012042:Registries; D009927:Tissue and Organ Procurement / Q000458:organization & administration