title: [Treatment of peritonitis under continuous ambulatory peritoneal dialysis using intraperitoneal ceftazidime].
abstract: Management of peritonitis related to chronic ambulatory peritoneal ceftazidime. In 15 patients under CAPD, 22 cases of bacterial peritonitis were observed with clinical manifestation in 14. The mean cell count in peritoneal dialysis fluid was 3 580/mm3 with 3 040/mm3 polymorphonuclear leukocytes. Causative pathogens were: Staphylococcus in 11 cases, Streptococcus in 3, Sarcines in 2, Corynebacterium in 2, Micrococcus varians in 1, Gram negative in 3. First choice treatment was a intraperitoneal injection of 1 g of ceftazidime every 48 hours, 54.5% of patients recovered within 5 days. Failures were due to 4 Staphylococcus aureus, 3 Staphylococcus epidermidis, 1 Sarcine, 1 Streptococcus liquefaciens, 1 Corynebacterium hofmanii. Mean ceftazidime concentrations 48 hours after the intraperitoneal injection were 35 mg/l (range = 14-54 mg/l) in serum and 5.5 mg/l (E: 2.8,8 mg/l) in dialysate. These concentrations in dialysate, are not greater than most of ceftazidime'S CMI for susceptible bacteria. A single daily intraperitoneal injection of ceftazidime is desirable.
authors.affiliation: Clinique Médicale et des Maladies Infectieuses, Hôpital Pellegrin-Tripode, Bordeaux.
authors.forename: J M
authors.initials: JM
authors.lastname: Ragnaud
authors.forename: M
authors.initials: M
authors.lastname: Dupon
authors.forename: P
authors.initials: P
authors.lastname: Morlat
authors.forename: M C
authors.initials: MC
authors.lastname: Bezian
authors.forename: C
authors.initials: C
authors.lastname: Wone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002442:Ceftazidime / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010538:Peritonitis / Q000188:drug therapy*
chemical_list: D002442:Ceftazidime
vernacular_title: Traitement des péritonites en dialyse péritonéale ambulatoire continue par la ceftazidime intrapéritonéale.