[The captopril test as a part of the examination in arterial hypertension. Value and immediate complications].
The results and immediate complications of oral administration of 6.25 mg captopril in 47 patients with arterial hypertension are described. The blood pressure was measured every 15 minutes for 90 minutes and the plasma renin concentration was measured before the test and at the conclusion of the test. Eleven of the patients had stenosis of the renal arteries. This investigation rendered it possible to differentiate this group from other patients with hypertension from other causes. Patients with renovascular hypertension had thus significant decrease in diastolic blood pressure and significant increase in plasma renin concentration in contrast to the remaining patients. Seven patients developed cerebral symptoms in connection with the decrease in blood pressure. Angiographic examination in two of these patients revealed stenosis of the vessels in the neck. Angiotensin converting enzyme inhibitors should be avoided in patients with recognized poor cerebral circulation or murmurs over the vessels in the neck.
Hansen
B P
BP
Garsdal
P
P
Fruergaard
P
P
D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply; D002216:Captopril / Q000009:adverse effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis*; D006978:Hypertension, Renovascular / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood
D002216:Captopril; D012083:Renin
Captopril-test som led i udredningen af hypertensio arterialis. Vaerdien heraf og umiddelbare komplikationer.