[Malignant peritoneal mesothelioma in a child. Diagnostic difficulties in a locally "non tumoral" form, revealed by cervical lymph node metastasis].
We report the unusual case-history of a ten-year-old girl who presented with enlarged cervical and supraclavicular lymph nodes apparently due to sinus histiocytosis upon initial histological evaluation. However, they were shown to be nodal metastases from an epithelial form of malignant mesothelioma coexpressing keratin, vimentin, and desmin. Exploratory laparotomy disclosed a diffuse "non tumoral" peritoneal mesothelioma. The neoplastic cells were so highly differentiated that analysis of peritoneal fluid pointed to reactive mesothelial hyperplasia. Intensive combination chemotherapy failed to achieve complete remission, but the child's condition was satisfactory after two and a half years follow-up. On the basis of data from the literature, we review the course, immunohistochemical features, and differential diagnosis of malignant peritoneal mesothelioma.
Bellocq
J P
JP
Chenard-Neu
M P
MP
Marcellin
L
L
Lassabe-Roth
C
C
Lutz
P
P
Clavert
J M
JM
Batzenschlager
A
A
D002648:Child; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology*; D008654:Mesothelioma / Q000175:diagnosis* / Q000473:pathology; D009333:Neck; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000473:pathology
Mésothéliome malin péritonéal chez un enfant. Difficultés diagnostiques devant une forme localement "non tumorale", à présentation métastatique ganglionnaire cervicale.