title: A case of bullous pemphigoid induced by tiobutarit (D-penicillamine analogue).
abstract: A 61-year-old woman with severe rheumatoid arthritis developed bullous lesions on the trunk, conjunctiva, and oral mucosa during treatment with tiobutarit, a new antirheumatic drug analogus to D-penicillamine. Histology showed a subepidermal blister, and circulating antibodies to the basement membrane zone were detected. The bullous lesions improved rapidly after discontinuation of tiobutarit. However, 3 years later, she was re-exposed to tiobutarit and the bullous lesions recurred within a week. This is the first confirmed case of tiobutarit-induced BP.
authors.forename: R
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: F
authors.initials: F
authors.lastname: Oryu
authors.forename: A
authors.initials: A
authors.lastname: Hidano
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003545:Cysteine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010391:Pemphigoid, Bullous / Q000139:chemically induced* / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*
chemical_list: D000893:Anti-Inflammatory Agents; D003545:Cysteine; C026535:bucillamine