title: Emptying of the gastric substitute after total gastrectomy. Jejunal interposition versus Roux-y esophagojejunostomy.
abstract: Emptying of the gastric substitute and small bowel transit time of a 99mTc-labeled solid test meal were measured in 20 tumor-free patients 13 to 63 (median, 35) months after total gastrectomy with Roux-y (n = 11) and jejunal interposition (n = 9) reconstruction. The emptying half-times ranged from 2 minutes to greater than 20 minutes. Rapid emptying was associated with dumping symptoms (p less than 0.03) and shorter orocoecal transit-time (p less than 0.05). Serum glucose concentrations rose more quickly in jejunal interposition, but the areas under the curve were identical in both groups. The median insulin-to-glucose ratio (areas under the curve) during the 20 minutes after the meal was 11.4 in jejunal interposition and 7.1 in Roux-y esophagojejunostomy (NS). Interposition cases had regained a significantly higher percentage (89%) of their premorbid weight than patients with Roux-y (78%; p less than 0.05). The weight/height2 ratio was above the 50th centile in 45% of interpositions, but below the 50th centile in all patients after the Roux-y mode of reconstruction (p less than 0.05). It is concluded that the emptying velocity of the gastric substitute has no impact on postoperative weight gain. The authors contend that the concept of a gastric substitute pouch is not supported by the findings of this study.
authors.affiliation: Klinik für Abdominal- und Transplantationschirurgie, Abteilung für Nuklearmedizin und spezielle Biophysik, Federal Republic of Germany.
authors.forename: J
authors.initials: J
authors.lastname: Miholic
authors.forename: H J
authors.initials: HJ
authors.lastname: Meyer
authors.forename: J
authors.initials: J
authors.lastname: Kotzerke
authors.forename: J
authors.initials: J
authors.lastname: Balks
authors.forename: H
authors.initials: H
authors.lastname: Aebert
authors.forename: J
authors.initials: J
authors.lastname: Jähne
authors.forename: A
authors.initials: A
authors.lastname: Weimann
authors.forename: R
authors.initials: R
authors.lastname: Pichlmayr
mesh_terms: D000713:Anastomosis, Roux-en-Y; D001786:Blood Glucose / Q000032:analysis; D004947:Esophagus / Q000601:surgery*; D005260:Female; D005743:Gastrectomy; D005746:Gastric Emptying; D006801:Humans; D007328:Insulin / Q000097:blood; D007583:Jejunum / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011178:Postgastrectomy Syndromes / Q000097:blood / Q000503:physiopathology; D011877:Radionuclide Imaging; D013274:Stomach Neoplasms / Q000601:surgery
chemical_list: D001786:Blood Glucose; D007328:Insulin