Regulation of tetrahydrobiopterin synthesis during lectin stimulation of human peripheral blood lymphocytes.
Lectin stimulation of human T lymphocytes causes a 7-fold increase in the specific activities of GTP-cyclohydrolase and a 4-fold increase in the specific activities of sepiapterin reductase. GTP-cyclohydrolase activities are maximal after 48 h and subsequently decline, whereas sepiapterin reductase activities continue to increase during the 72 h period measured. The specific activities of 6-pyruvoyltetrahydropterin synthase remain unchanged upon stimulation. Tetrahydrobiopterin synthesis during blast transformation is thus directed by both GTP-cyclohydrolase and sepiapterin reductase.
Kerler
F
F
GSF-Institut für Experimentelle Hämatologie, München, FRG.
Ziegler
I
I
Schwarzkopf
B
B
Bacher
A
A
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D001708:Biopterins / Q000031:analogs & derivatives* / Q000096:biosynthesis; D055598:Chemical Phenomena; D002621:Chemistry; D006136:GTP Cyclohydrolase / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000494:pharmacology*; D019761:Phosphorus-Oxygen Lyases; D013601:T-Lymphocytes / Q000378:metabolism*
D037102:Lectins; D001708:Biopterins; D000429:Alcohol Oxidoreductases; C022630:sepiapterin reductase; D006136:GTP Cyclohydrolase; D019761:Phosphorus-Oxygen Lyases; C043497:6-pyruvoyltetrahydropterin synthase; C003402:sapropterin