[Serum hippurate levels in patients with liver cirrhosis under basal conditions and after glucose administration].
In a group of 12 healthy volunteers and 10 patients with livers cirrhosis the concentration of glucose, insulin, and hippurate was studied during glucose tolerance test after peroral administration of 75 g glucose. Basal values of glycemia and insulin were increased. The course of the glycemic curve was pathological in all intervals studied (p less than 0.001). After a slight latency, the insulin level exhibited a sharp rise in the 30th min (p 0.001). The basal hippurate level was slightly diminished and its decrease in the course of the oral glucose tolerance test was similar to that seen in the volunteers. Reduced hippurate synthesis in the liver and its alternative synthesis in the kidneys is being documented.
Spustová
V
V
Kupcová
V
V
Brixová
E
E
D001786:Blood Glucose / Q000032:analysis; D005951:Glucose Tolerance Test; D006626:Hippurates / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood*
D001786:Blood Glucose; D006626:Hippurates; D007328:Insulin
Hladina hipuranu v sére u pacientov s cirhózou pecene za bazálnych podmienok a po podaní glukózy.