Urinary protein excretion following intravenously administered ionic and non-ionic contrast media in man.
Urinary protein excretion following intravenous administration of the radiographic contrast media (CM) diatrizoate (ionic) and iopromide (non-ionic) was examined in 20 patients with normal renal function. Neither of the two CM had any effect on the 24-h urinary excretion of albumin (a marker of glomerular proteinuria). The 24-h urinary excretion of the retinol-binding protein (a marker of low molecular weight or tubular proteinuria) and the folate binding protein, a protein localized in the brush-border membranes of the proximal tubular cells, showed a statistically significant transient increase the day after diatrizoate injection, whereas no increase was observed after iopromide. Thus, only a minimal and temporary disturbance of the renal proximal tubular function was observed after diatrizoate injection in patients with normal renal function.
Skovgaard
N
N
Department of Radiology, Central Hospital, Falster, Denmark.
Holm
J
J
Hemmingsen
L
L
Skaarup
P
P
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000139:chemically induced; D002352:Carrier Proteins / Q000652:urine; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D003974:Diatrizoate Meglumine / Q000008:administration & dosage / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D058973:Folate Receptors, GPI-Anchored; D006801:Humans; D007275:Injections, Intravenous; D007472:Iohexol / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives; D007668:Kidney / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011507:Proteinuria / Q000139:chemically induced*; D016032:Randomized Controlled Trials as Topic; D011956:Receptors, Cell Surface; D012177:Retinol-Binding Proteins / Q000652:urine
D002352:Carrier Proteins; D003287:Contrast Media; D058973:Folate Receptors, GPI-Anchored; D011956:Receptors, Cell Surface; D012177:Retinol-Binding Proteins; D003974:Diatrizoate Meglumine; D007472:Iohexol; C038192:iopromide