Early events in lymphopoiesis: the role of interleukins 1 and 7.
This article summarizes evidence that interleukins 1 and 7 play a critical role in the early stages of lymphopoiesis. IL-1 has been demonstrated to be identical to the growth factor previously termed haemopoietin-1 and appears to cause the growth of haemapoietic stem cells. Interleukin-7, originally described as a pre-B-cell growth factor, also has proliferative activity on T cells. It is proposed that IL-7 acts on lymphoid stem cells.
Henney
C S
CS
Immunex Corporation, Seattle, WA 98101.
D000818:Animals; D003114:Colony-Forming Units Assay; D006410:Hematopoiesis; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000494:pharmacology*; D015851:Interleukin-7; D007378:Interleukins / Q000494:pharmacology*; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology
D007375:Interleukin-1; D015851:Interleukin-7; D007378:Interleukins