title: Pharmacokinetics of felodipine after intravenous and chronic oral administration in patients with congestive heart failure.
abstract: 1. In a randomized, parallel, double-blind study felodipine was administered to 11 and placebo to 12 patients with congestive heart failure. The kinetics of felodipine were studied after acute intravenous administration and after chronic oral treatment for 8 weeks. The relationship between cardiac output and pharmacokinetics was analyzed. The pharmacokinetic data were compared with data from young healthy individuals and hypertensive patients. 2. After oral therapy, significant correlations were found between cardiac output and AUC and systemic bioavailability (F). Furthermore, cardiac output before therapy was also significantly correlated with absorption characteristics. No relationship could be demonstrated between cardiac output and i.v. pharmacokinetics. A comparison of patients with heart failure and young healthy individuals revealed that the AUC was three times higher in heart failure patient, while Vss and the ratio of the AUC of the pyridine metabolite to that of felodipine were similar. Oral clearance was reduced by 50% and the terminal half-life was concomitantly increased. Pharmacokinetic data for felodipine are similar in patients with heart failure to published data from elderly hypertensive patients. 3. An increase in liver blood flow during chronic oral therapy, induced by felodipine itself, appears to explain an increase in bioavailability and thus to higher plasma drug concentrations. Thus, it is advisable to start felodipine treatment at a low dosage in patients with congestive heart failure.
authors.affiliation: Department of Cardiology, Groningen University, The Netherlands.
authors.forename: P H
authors.initials: PH
authors.lastname: Dunselman
authors.forename: B
authors.initials: B
authors.lastname: Edgar
authors.forename: A H
authors.initials: AH
authors.lastname: Scaf
authors.forename: C E
authors.initials: CE
authors.lastname: Kuntze
authors.forename: H
authors.initials: H
authors.lastname: Wesseling
mesh_terms: D000284:Administration, Oral; D000368:Aged; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002302:Cardiac Output / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D015736:Felodipine; D005260:Female; D006333:Heart Failure / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011897:Random Allocation
chemical_list: D002121:Calcium Channel Blockers; D009568:Nitrendipine; D015736:Felodipine