[Effect of sinestrol on the course of the myodystrophic process in progressive Duchenne muscular dystrophy].
Therapeutic effect of sinestrol was investigated in 15 patients with progressive muscular dystrophy of Duchenne (PMDD) aged 7 to 10 years, at stage II of the disease. The drug was given orally 1 mg twice a day for 3 weeks. Control group consisted of 14 patients with PMDD aged 7 to 9 years. By the end of the course a several relief of motor constraint was noted in 10 patients with functional tests improved, tendon reflexes increased. The results of clinico-electromyographic investigation performed 6 months after the sinestrol withdrawal evidenced progressive course of the disease, though its rate was significantly lower in sinestrol-treated group. The treatment did not produce considerable changes in the baseline hormonal profile (gonadotropins, prolactin, sexual steroids).
Zavadenko
N N
NN
Kamennykh
L N
LN
D000284:Administration, Oral; D002648:Child; D002986:Clinical Trials as Topic; D004028:Dienestrol / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009136:Muscular Dystrophies / Q000188:drug therapy* / Q000503:physiopathology; D010636:Phenols / Q000008:administration & dosage*; D013997:Time Factors
D010636:Phenols; D004028:Dienestrol
Issledovanie vliianiia sinéstrola na techenie miodistrofi- cheskogo protsessa pri progressiruiushcheĭ myshechnoĭ distrofii Diushenna.