title: Long-term effects of altered activity on skeletal muscle.
abstract: This paper is a brief summary of some results obtained by stimulating denervated rat soleus (SOL) and extensor digitorum longus (EDL) muscles in vivo with different patterns of stimuli. It is concluded (1) that appropriate stimulation can maintain and restore normal properties in extrajunctional regions of denervated muscle; (2) that SOL and EDL respond differently to identical stimulation, indicating that the two muscles are intrinsically different; (3) that both frequency and amount of stimulation influence contractile properties but to varying degrees depending on the property and on the type of muscle under study; and (4) that the effects of stimulation on isometric and isotonic speed of shortening can be partly accounted for by its effect on excitation-contraction coupling processes and myosin heavy chain (MHC) expression.
authors.affiliation: Institute of Neurophysiology, University of Oslo, Norway.
authors.forename: T
authors.initials: T
authors.lastname: Lømo
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D007124:Immunoenzyme Techniques; D008297:Male; D009119:Muscle Contraction; D009121:Muscle Denervation; D009132:Muscles / Q000033:anatomy & histology / Q000201:enzymology / Q000502:physiology*; D009218:Myosins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009218:Myosins