Antimicrobial therapy for pediatric patients.
New antimicrobial agents are being introduced for clinical use at an increasingly rapid rate. This has required physicians continually to review relevant data and determine unique properties that might guide selection among any new antibiotics as well as older ones. Efficacy, potential toxicity, and comparative cost (in that order) generally guide selection. The present comprehensive review examines currently available antibiotics along with some under investigation, emphasizing these three basic areas of consideration.
Steele
R W
RW
University of Arkansas for Medical Sciences, Little Rock.
Kearns
G L
GL
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D002511:Cephalosporins / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D002701:Chloramphenicol / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004358:Drug Therapy / Q000191:economics; D015507:Drugs, Investigational; D006311:Hearing Disorders / Q000139:chemically induced; D006801:Humans; D006932:Hyperbilirubinemia / Q000139:chemically induced; D007223:Infant; D007668:Kidney / Q000187:drug effects; D010372:Pediatrics; D013921:Thrombocytopenia / Q000139:chemically induced
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D015507:Drugs, Investigational; D002701:Chloramphenicol