[Future perspectives of kidney transplant: towards a specific immunosuppression?].
The current status of immunosuppression in renal transplants is reviewed: non-specific (corticosteroids and cytostatics), lymphocyte-specific (polyclonal antilymphocyte globulin), T-specific (cyclosporine, antithymocyte polyclonal gamma globulin) with special attention to the OKT3 and monoclonal antibodies. Supported by the current experience of the use of PAN-T (OKT3) antiidiotypic monoclonal antibodies in the graft rejection treatment, a hypothesis is elaborated--feasible to demonstrate--to determine what would happen if anti-clonotypic monoclonal antibodies (the idiotypes of T lymphocytes) are used when looking for a specific immunosuppression. We conclude that the immunosuppression with anti-idiotypes, if it is confirmed, would be almost ideal.
Ortiz Arduan
A
A
Gutiérrez
J R
JR
Méndez
A
A
Ortiz
A
A
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D005544:Forecasting; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D016030:Kidney Transplantation; D014181:Transplantation Immunology
D000911:Antibodies, Monoclonal
Perspectivas futuras del trasplante renal: hacia una inmunosupresión específica?