title: RNA editing: the creation of nucleotide sequences in mRNA--a minireview.
abstract: RNA editing changes the nucleotide sequence of mRNAs that are encoded in genes which contain the sequences in an abbreviated form. Editing adds uridines that are not encoded in the gene to the transcripts and less frequently removes encoded uridines. The process appears to be posttranscriptional and to proceed in the 3'-to-5' direction. Some sites may undergo multiple editings until the final sequence is produced; in some cases uridines may be added and subsequently removed. A general hypothesis is proposed that predicts a series of reactions that may occur in association with a macromolecular complex, the editosome, which interacts with a multinucleotide region.
authors.affiliation: Seattle Biomedical Research Institute, WA 98109-1651.
authors.forename: K
authors.initials: K
authors.lastname: Stuart
authors.forename: J E
authors.initials: JE
authors.lastname: Feagin
authors.forename: J M
authors.initials: JM
authors.lastname: Abraham
mesh_terms: D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D004247:DNA / Q000235:genetics; D004722:Endoribonucleases / Q000378:metabolism; D056890:Eukaryota / Q000235:genetics*; D005786:Gene Expression Regulation; D008969:Molecular Sequence Data; D011061:Poly A / Q000235:genetics; D011130:RNA Ligase (ATP) / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D014346:Trypanosoma brucei brucei / Q000235:genetics; D014529:Uridine / Q000235:genetics* / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D011061:Poly A; D004247:DNA; D004722:Endoribonucleases; D011130:RNA Ligase (ATP); D014529:Uridine