Substances with antineoplastic activity. XCVI. Some pharmacological properties and therapeutic synergism of 6-purinyl-N-(2-chloroethyl)thiocarbamate with cytosine arabinoside.
The cancerostatic effect of 6-purinyl-N-(2-chloroethyl)thiocarbamate (Cloturin VUFB, VUFB-15686) was studied in detail in mice and rats bearing transplantable tumors. The cytotoxic activities were measured by determining the incorporation rate of 5-iodo-2'-deoxy[6-3H]uridine and uniformly labeled [U-14C]amino acid mixture into trichloroacetic acid-insoluble fraction of Yoshida ascites reticulosarcoma cells during a short-term incubation with the drug. From the results obtained it follows that the new substance is therapeutically more effective in comparison with 6-mercaptopurine (NSC-755). A therapeutic synergism of Cloturin with cytosine arabinoside (NSC-63978) was observed.
Mĕlka
M
M
Research Institute for Pharmacy and Biochemistry, Prague, Czechoslovakia.
Krepelka
J
J
Miko
M
M
Pokorná
S
S
Kejhová
I
I
Reichlová
R
R
Beitová
M
M
Grimová
J
J
Kargerová
A
A
Sedivá
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage / Q000627:therapeutic use*; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects; D005260:Female; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000378:metabolism; D008546:Melanoma, Experimental / Q000188:drug therapy; D015122:Mercaptopurine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL; D009150:Mustard Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D012334:RNA, Neoplasm / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D009150:Mustard Compounds; D012334:RNA, Neoplasm; D003561:Cytarabine; C057648:Cloturin; D015122:Mercaptopurine