[Relation between plasma catecholamines, the severity of the liver disease and hemodynamics in patients with cirrhosis].
Plasma noradrenaline and adrenaline concentrations were measured in 75 patients with cirrhosis in order to attempt to correlate these concentrations and liver failure and hemodynamic changes. The increased noradrenaline concentration was not correlated with the degree of liver failure estimated by Pugh's classification, with the cause of cirrhosis, with the presence of acute alcoholic hepatitis or with the presence of ascites. Adrenaline concentration was higher in cirrhotic patients with acute alcoholic hepatitis than in those without these lesions. Noradrenaline concentration was significantly correlated with heart rate, wedged hepatic venous pressure and renal blood flow. Noradrenaline concentration was also negatively correlated with stroke volume and adrenaline concentration was negatively correlated with cardiac output and stroke volume. These findings confirm the relationships between portal hypertension, sympathetic hyperactivity and renal function in patients with cirrhosis.
Gaudin
C
C
Unité de Recherches de Physiopathologie Hépatique, INSERM U-24, Hôpital Beaujon, Clinchy.
Braillon
A
A
Moreau
R
R
Roulot
D
D
Bacq
Y
Y
Hadengue
A
A
Lebrec
D
D
D000328:Adult; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D012079:Renal Circulation / Q000502:physiology; D012083:Renin / Q000097:blood; D013152:Splanchnic Circulation / Q000502:physiology
D012083:Renin; D009638:Norepinephrine; D004837:Epinephrine
Relations entre les catécholamines plasmatiques et la sévérité de la maladie du foie et l'hémodynamique des malades atteints de cirrhose.