[ICO-63 monoclonal antibodies to the differentiation antigen of hemopoietic cells suitable for immunophenotyping of human solid tumors].
ICO-63, new monoclonal antibodies (MCAB), used for immunodiagnosis, were produced by the standard hybridoma technique ICO-63 MCAB reacted with 50% granulocytes, 20% thrombocytes and endothelial cells, whereas they did not react with peripheral blood mononuclear cells, thymocytes and erythrocytes. The molecular weight of ICO-63 MCAB-identified antigen was about 100 kD. ICO-63 MCAB reacted with 12 out of 15 neuroblastomas, with some solid tissue sarcomas and melanomas, but did not react with tumours of the epithelial origin.
Baryshnikov
A Iu
AIu
Kadyrov
Kh P
KhP
Tupitsyn
N N
NN
Kadagidze
Z G
ZG
Petrovichev
N N
NN
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000302:isolation & purification; D000943:Antigens, Differentiation / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D007124:Immunoenzyme Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D009369:Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000276:immunology; D010641:Phenotype
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm
Monoklonal'nye antitela IKO-63 k differentsirovochnomu antigenu gemopoéticheskikh kletok, prigodnye dlia immunofenotipirovaniia solidnykh opukholeĭ cheloveka.