title: A trial using early preoperative administration of cefonicid for antimicrobial prophylaxis with hysterectomies.
abstract: A single dose of cefonicid given 3.5-5.0 hours or 0.5-1.0 hour preoperatively was compared with cefoxitin given as five doses beginning 0.5-1.0 hour preoperatively for prophylaxis of infection in 202 patients undergoing vaginal or abdominal hysterectomy. The administration of cefonicid 3.5-5.0 hours preoperatively was intended to simulate situations where surgery may be delayed or prolonged. The trial was double-blind, and patients were randomized to one of the three regimens. Operative site infections were noted in 6.2 percent of patients (7/113) who received cefonicid 3.5-5.0 hours preoperatively, in 7.0 percent of patients (3/43) who received cefonicid 0.5-1.0 hour preoperatively, and in 4.3 percent of patients (2/46) who received cefoxitin (p greater than 0.05). Enterococci were isolated most frequently from operative-site infections. When administered 3.5-5.0 hours preoperatively, cefonicid was as effective as more traditional regimens.
authors.affiliation: Georgetown School of Medicine, Washington, DC.
authors.forename: L J
authors.initials: LJ
authors.lastname: Eron
authors.forename: S F
authors.initials: SF
authors.lastname: Gordon
authors.forename: L K
authors.initials: LK
authors.lastname: Harvey
authors.forename: J G
authors.initials: JG
authors.lastname: Sites
mesh_terms: D000293:Adolescent; D000328:Adult; D015790:Cefonicid / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D011292:Premedication; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D015790:Cefonicid