[Role of calcium blockers in protecting the myocardium in cardiac surgery].
Calcium plays an essential role in ischemic events observed during cardiac surgery. Many experiments have studied the effects of calcium channel blockers on intracellular calcium overload during the periods of cardiac ischemia and reperfusion. Calcium channel blockers are no longer used before and during cardiac surgery because hypothermia inhibits their pharmacological action. However, during the post-operative period, calcium channel blockers are the drugs of choice to control coronary spasm, and arterial hypertension which is secondary to peripheral vasoconstriction.
Piwnica
A
A
Menasche
P
P
D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures; D009202:Cardiomyopathies / Q000517:prevention & control*; D002314:Cardioplegic Solutions / Q000627:therapeutic use; D006801:Humans; D007432:Intraoperative Period; D011184:Postoperative Period
D002121:Calcium Channel Blockers; D002314:Cardioplegic Solutions
Rôle des inhibiteurs calciques dans la protection du myocarde en chirurgie cardiaque.