Evaluation of dialyzers used in shortened dialysis.
The clearance of urea and beta 2-microglobulin are important considerations along with biocompatibility in selecting membranes for use in shortened dialysis. During 3 hr of dialysis we have measured the in vivo urea clearances, pre- and post-beta 2-M levels, plasma clearance and simultaneous dialysance of beta 2-M. Leucopenia was compared after 15 min of dialysis on a cellulose acetate (CA) dialyzer and a polyacrylonitrile dialyzer (PAN). Clearance of urea was similar in both dialyzers. In contrast to CA, PAN removed beta 2-M and exhibited minimal leucopenia. The dialysance of beta 2-M was significantly less than the simultaneous blood side clearance. The disparity between blood clearance and dialysance by PAN membranes suggests removal of beta 2-M by adsorption and diffusion. We conclude that in comparison with CA dialyzers, PAN membranes remove beta 2-M, have equivalent urea clearances, and are more biocompatible.
Petersen
J
J
Division of Nephrology, Stanford University, California.
Ramsey
K D
KD
Kang
M S
MS
Yeh
I T
IT
D000180:Acrylic Resins; D002482:Cellulose / Q000031:analogs & derivatives*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D007688:Kidneys, Artificial; D007958:Leukocyte Count; D008567:Membranes, Artificial; D008657:Metabolic Clearance Rate; D009504:Neutrophils; D014508:Urea / Q000097:blood*; D001613:beta 2-Microglobulin / Q000378:metabolism*
D000180:Acrylic Resins; D008567:Membranes, Artificial; D001613:beta 2-Microglobulin; C010504:polyacrylonitrile; C005062:acetylcellulose; D014508:Urea; D002482:Cellulose