title: Lipid peroxidation during the oxidation of haemoproteins by hydroperoxides. Relation to electronically excited state formation.
abstract: The formation of electronically excited states during hydroperoxide metabolism is analysed in terms of recombination reactions involving secondary peroxyl radicals and scission of the O-O bond of peroxides by haemoproteins, mainly myoglobin. Both processes may be sequentially interrelated, for the cleavage of H2O2 by metmyoglobin leads to the formation of a strong oxidizing equivalent with the capability to promote peroxidation of polyunsaturated fatty acids. The decomposition of lipid hydroperoxides by ferryl-hydroxo complexes, as that formed during the oxidation of metmyoglobin by H2O2, is a source of peroxyl radicals, the recombination of which proceeds with elimination of a conjugated triplet carbonyl or singlet oxygen.
authors.affiliation: Department of Pathology II, University of Linköping, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Cadenas
mesh_terms: D000818:Animals; D005609:Free Radicals; D006420:Hemeproteins / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D015227:Lipid Peroxidation; D008163:Luminescent Measurements; D010084:Oxidation-Reduction
chemical_list: D005609:Free Radicals; D006420:Hemeproteins; D006861:Hydrogen Peroxide