Naloxone suppression of self-stimulation is independent of response difficulty.
The action of the opiate antagonist naloxone on relatively easy (nose-poke) and relatively difficult (lever-press) self-stimulation behaviors was compared, in order to determine if opiate antagonists suppress self-stimulation by interfering with the ability of the animal to respond, or by reducing the reinforcement value of the stimulation. Naloxone (0.2, 2.0 and 20 mg/kg) significantly suppressed both nose-poking and lever-pressing self-stimulation rates, and the degree of suppression was virtually identical for both tasks at all doses examined. If naloxone had interfered with the ability of the animal to respond, then lever-pressing--which requires more motor output than nose-poking--should have been more suppressed than nose-poking. The results suggest that opiate antagonists do not interfere with the ability of the animal to respond, and are therefore consistent with the hypothesis that these drugs reduce the reinforcement value of the stimulation.
Trujillo
K A
KA
Department of Pharmacology, College of Medicine, University of California, Irvine 92717.
Belluzzi
J D
JD
Stein
L
L
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004567:Electrodes, Implanted; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000033:anatomy & histology / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation / Q000187:drug effects*; D013238:Stereotaxic Techniques
D009270:Naloxone