Towards the development of antimicrobial drugs acting by inhibition of pathogen attachment to host cells: a need for polyvalency.
The development of inhibitors of microbial attachment to target cells has been proposed recently as a possible novel approach to antimicrobial chemoprophylaxis and treatment. In this paper an attempt is made to contend that such artificial inhibitors must be polyvalent, i.e. capable of binding to the pathogen or its target by multiple bonds.
Matrosovich
M N
MN
Institute of Poliomyelitis and Viral Encephalitides, USSR Academy of Medical Sciences, Region.
D000268:Adhesiveness; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001422:Bacterial Adhesion / Q000187:drug effects*; D011991:Receptors, Virus / Q000187:drug effects; D014780:Viruses / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D011991:Receptors, Virus