Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies.
Ganoderan B increased the plasma insulin level in normal and glucose-loaded mice but elicited no effect on insulin binding to isolated adipocytes. Administration of ganoderan B elicited significant increases of the activities of hepatic glucokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase, decreased the hepatic glucose-6-phosphate and glycogen synthetase activities and did not affect the activities of hexokinase and glycogen phosphorylase. Ganoderan B reduced the glycogen content in the liver but had no influence on total cholesterol and triglyceride levels in the plasma and liver.
Hikino
H
H
Ishiyama
M
M
Suzuki
Y
Y
Konno
C
C
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000097:blood*; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D011134:Polysaccharides / Q000494:pharmacology*; D014280:Triglycerides / Q000378:metabolism
D007328:Insulin; D011134:Polysaccharides; D014280:Triglycerides; D002784:Cholesterol; C047407:ganoderan B; D005947:Glucose