title: Morphogen gradients and the control of body pattern in insect embryos.
abstract: The basic body plan of insects is set up in response to determinants initially localized at the anterior and posterior poles of the egg. Early in development, these determinants give rise to a series of morphogen gradients which in turn trigger a cascade of molecular signals determining the body pattern. This signalling process is outlined and recent experiments testing the roles of these gradient systems in determining anterior and posterior pattern are described. The results of these experiments suggest that anterior pattern is controlled by a single instructive gradient, whereas posterior pattern depends on the overlap of several gradients, each providing only one or a few distinct responses.
authors.affiliation: Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032.
authors.forename: G
authors.initials: G
authors.lastname: Struhl
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004330:Drosophila / Q000196:embryology / Q000235:genetics; D005796:Genes; D007301:Insect Hormones / Q000235:genetics*; D007313:Insecta / Q000196:embryology* / Q000235:genetics; D009024:Morphogenesis; D014158:Transcription, Genetic
chemical_list: D007301:Insect Hormones