[Glucose tolerance and electrolyte metabolism in nifedipine and nifedipine dihydroergotoxin treated healthy subjects].
The effects of three oral doses of nifedipine 20 mg or nifedipine 20 mg/dihydroergotoxin 2 mg (Pontuc, HN 85) during three subsequent days on an oral glucose load (100 g) were compared to placebo. Neither drug altered the glucose load or inhibited the secretion of insulin or C-peptide. The fall of serum potassium was also identical to controls. Basal plasma norepinephrine concentrations were lower following nifedipine/dihydroergotoxine than after nifedipine alone (2 p less than 0.05). A decrease of the serum sodium concentration by 2 mmol/l was observed with nifedipine but not with the combined drugs.
Petersen
K G
KG
Abteilung Klinische Endokrinologie und Stoffwechsel der Albert-Ludwigs-Universität Freiburg/Brsg.
Ortgiese
R
R
Schuler
G
G
Khalaf
N
N
Schliebs
B
B
Kerp
L
L
D000328:Adult; D002096:C-Peptide / Q000097:blood; D004088:Dihydroergotoxine / Q000008:administration & dosage / Q000494:pharmacology*; D004573:Electrolytes / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D009638:Norepinephrine / Q000097:blood; D012083:Renin / Q000097:blood
D002096:C-Peptide; D004573:Electrolytes; D007328:Insulin; D004088:Dihydroergotoxine; D012083:Renin; D009543:Nifedipine; D005947:Glucose; D009638:Norepinephrine
Glukose-Toleranz und Elektrolytstoffwechsel unter Nifedipin und Nifedipin-Dihydroergotoxin bei Gesunden.