title: Methylreductic acid and hydroxymethylreductic acid: oxygen radical-forming agents in heated starch.
abstract: Two compounds forming oxygen radicals were isolated from heated starch by monitoring the potency to form 8-hydroxydeoxyguanosine from deoxyguanosine during purification procedures. These compounds were identified as hydroxymethylreductic acid and methylreductic acid. The former compound was mutagenic to Salmonella strains TA100, TA102 and TA104 and the latter compound induced sister-chromatid exchanges in human NL3 cells. Hydroxymethylreductic acid was found to be a novel compound. Considerable amounts of these compounds were detected in various heat-processed foods.
authors.affiliation: Biology Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kasai
authors.forename: M
authors.initials: M
authors.lastname: Nakayama
authors.forename: N
authors.initials: N
authors.lastname: Toda
authors.forename: Z
authors.initials: Z
authors.lastname: Yamaizumi
authors.forename: J
authors.initials: J
authors.lastname: Oikawa
authors.forename: S
authors.initials: S
authors.lastname: Nishimura
mesh_terms: D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D003517:Cyclopentanes / Q000633:toxicity*; D005609:Free Radicals; D006358:Hot Temperature; D009152:Mutagenicity Tests; D009153:Mutagens; D010100:Oxygen / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D013213:Starch
chemical_list: D003517:Cyclopentanes; D005609:Free Radicals; D009153:Mutagens; C060824:hydroxymethylreductic acid; C060823:methylreductic acid; D013213:Starch; D010100:Oxygen