title: Serotonin and depression: old problems and new data.
abstract: 1. Several lines of evidence implicating some dysfunction or alteration to brain serotonergic systems in depressive states are summarized. 2. Some aspects of the interactions between the 5-HT and catecholamine pathways in the action of antidepressant drugs are examined. 3. Finally, the important role of NA modulation of serotonergic activity in the action of antidepressants is suggested.
authors.affiliation: Department of Pharmacology and Physiology of the Nervous System, Psychoneurological Institute, Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Plaznik
authors.forename: W
authors.initials: W
authors.lastname: Kostowski
authors.forename: T
authors.initials: T
authors.lastname: Archer
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D003866:Depressive Disorder / Q000378:metabolism*; D006801:Humans; D012701:Serotonin / Q000378:metabolism*
chemical_list: D002395:Catecholamines; D012701:Serotonin