Clearance of beta-2-microglobulin using continuous ambulatory peritoneal dialysis.
In the 9 continuous ambulatory peritoneal dialysis (CAPD) patients studied, the mean clearance of beta 2-microglobulin was significantly higher using hypertonic as opposed to isotonic exchanges (1 ml/min and 0.75 ml/min, respectively). Clearance of beta 2-microglobulin correlated with the clearance of albumin. The daily mass transfer of beta 2-microglobulin ranged from 19 to 62 mg. Although all the daily production of beta 2-microglobulin is not eliminated in patients on CAPD their serum beta 2-microglobulin levels would be expected to be lower than in patients on haemodialysis. Long-term prospective studies are needed to determine whether lower serum beta 2-microglobulin levels lead to a lower incidence of dialysis amyloid.
Sethi
D
D
Department of Medicine, Charing Cross Hospital, London, UK.
Murphy
C M
CM
Brown
E A
EA
Müller
B R
BR
Gower
P E
PE
D001202:Ascitic Fluid / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism; D008657:Metabolic Clearance Rate; D010531:Peritoneal Dialysis, Continuous Ambulatory; D012709:Serum Albumin / Q000493:pharmacokinetics; D014462:Ultrafiltration; D014508:Urea / Q000378:metabolism; D001613:beta 2-Microglobulin / Q000493:pharmacokinetics*
D012709:Serum Albumin; D001613:beta 2-Microglobulin; D014508:Urea; D003404:Creatinine