title: Octanoate transport in the isolated, perfused rat liver.
abstract: The multiple indicator dilution technique was used to investigate octanoate transport in the isolated, perfused rat liver. The form of the octanoate outflow profiles depends on albumin concentration. The steady-state intracellular octanoate concentration and the rate of uptake increase when the albumin concentration is decreased. At physiological albumin concentrations, the intracellular concentration of octanoate is only 7% of the extracellular concentration. Exchange between the intra- and extracellular space, however, is very rapid, irrespective of the albumin concentration and consequently exchange is not rate limiting for metabolism.
authors.affiliation: Laboratório de Metabolismo Hepático, Universidade Estadual de Maringá, Brasil.
authors.forename: J
authors.initials: J
authors.lastname: Constantin
authors.forename: M G
authors.initials: MG
authors.lastname: Souza
authors.forename: O
authors.initials: O
authors.lastname: Ferraresi
authors.forename: M L
authors.initials: ML
authors.lastname: Ferraresi
authors.forename: E L
authors.initials: EL
authors.lastname: Ishii-Iwamoto
authors.forename: A
authors.initials: A
authors.lastname: Bracht
mesh_terms: D000418:Albumins / Q000378:metabolism*; D000818:Animals; D002210:Caprylates / Q000493:pharmacokinetics*; D007201:Indicator Dilution Techniques; D008099:Liver / Q000378:metabolism*; D008433:Mathematics; D051381:Rats; D013995:Time
chemical_list: D000418:Albumins; D002210:Caprylates; C031492:octanoic acid