Recovery from polyclonal tolerance: simulation analysis.
Mathematical model of immunological tolerance was applied to polyclonal B cell tolerance induced in mice by treatment with bacterial lipopolysaccharide (LPS) followed by the application of cyclophosphamide (CY). Satisfactory simulation results were obtained with the life-span of lymphocytes shorter than the experimentally observed one. It could be assumed that the massive decrease of lymphocyte population in polyclonal tolerance would elicit a compensatory reaction. Therefore it was postulated that some kind of feedback mechanism increased the influx of B lymphocytes. Having this factor included in the model, satisfactory agreement of the simulation results with experimental data was obtained for experimentally determined life-span of B cells.
Dolezal
J
J
Institute of Information Theory and Automation, Czechoslovak Academy of Sciences, Praha.
Fontalin
L N
LN
Kondratieva
T K
TK
Hraba
T
T
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D003520:Cyclophosphamide / Q000494:pharmacology; D007108:Immune Tolerance; D008070:Lipopolysaccharides / Q000276:immunology; D008212:Lymphocyte Depletion; D008433:Mathematics; D051379:Mice; D008954:Models, Biological; D012706:Serratia marcescens / Q000276:immunology; D013997:Time Factors
D008070:Lipopolysaccharides; D003520:Cyclophosphamide