[The in-vitro action of chloroquine on the infectivity of gametocytes of Plasmodium berghei Anka].
The influence of chloroquine on the infectivity of gametocytes of P. berghei Anka chloroquino-sensitive was assessed in vitro. It was found that chloroquine could not affect the exflagellation of microgametocytes but prevented the formation of ookinetes at the concentration of 10 micrograms/ml. This activity seemed to be stage and dose dependent.
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Wéry
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D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D010962:Plasmodium berghei / Q000187:drug effects / Q000472:pathogenicity*; D014774:Virulence / Q000187:drug effects
D002738:Chloroquine
Action in vitro de la chloroquine sur l'infectivité des gamétocytes de Plasmodium berghei Anka.