Acute inflammatory effects of a monocyte-derived neutrophil-activating peptide in rabbit skin.
The inflammatory effects of a monocyte-derived neutrophil-activating peptide (MONAP), purified to homogeneity from lipopolysaccharide-stimulated human peripheral blood monocytes, have been evaluated in rabbit skin. Intradermal injection of MONAP alone caused a mild infiltration of polymorphonuclear leucocytes (PMNL) but did not induce any change in plasma extravasation. When combined with prostaglandin E2(PGE2), MONAP caused a marked and synergistic increase in PMNL infiltration and plasma extravasation into the injected skin sites. The increase in vascular permeability induced by MONAP depended on the presence of circulating PMNL. MONAP is a novel cytokine with pro-inflammatory properties and may have physiological and pathophysiological roles in health and disease.
Foster
S J
SJ
ICI Pharmaceuticals, Cheshire U.K.
Aked
D M
DM
Schröder
J M
JM
Christophers
E
E
D000818:Animals; D002199:Capillary Permeability; D002630:Chemotactic Factors / Q000008:administration & dosage*; D002634:Chemotaxis, Leukocyte; D015232:Dinoprostone / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007271:Injections, Intradermal; D016209:Interleukin-8; D007958:Leukocyte Count; D009000:Monocytes / Q000276:immunology*; D009504:Neutrophils / Q000473:pathology; D011817:Rabbits; D012867:Skin / Q000098:blood supply / Q000276:immunology / Q000473:pathology*
D002630:Chemotactic Factors; D016209:Interleukin-8; D015232:Dinoprostone