The effect of cholecystokinin octapeptide and glucagon (1-29) on food intake of weanling rats.
Cholecystokinin octapeptide (CCK-8) and glucagon (GLG) decrease food intake of a number of species. However, the responsiveness of rats to the food intake effects of these peptides may develop differentially due to sex, age and/or developmental state. Male and female weanling rats decreased early dark cycle food intake following the administration of 5 and 10 micrograms/kg CCK-8 and male rats were more responsive than female rats, p less than 0.05. GLG did not decrease early dark cycle food intake of either male or female weanling rats. Weanling male rats increased plasma glucose and insulin levels in response to GLG administration, p less than 0.05. Male rats were retested with GLG (250 and 500 micrograms/kg) at 6, 9 and 22 weeks of age. GLG did not decrease food intake of these rats until they reached 9 weeks of age and they were still responsive at 22 weeks of age, p less than 0.05.
Wager-Srdar
S A
SA
Neuroendocrine Laboratory, Veterans Administration Medical Center, Minneapolis, MN 55417.
Levine
A S
AS
D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001786:Blood Glucose / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D012844:Sincalide / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D012844:Sincalide