[Naf/nap-1, a new peptide which activates neutrophil leukocytes].
NAF/NAP-1 is a novel tissue-derived chemotactic peptide. It consists of 72 amino acids and has no sequence homology to known cytokines. NAF/NAP-1 is produced by a wide variety of cells after stimulation with interleukin-1, tumor necrosis factor or endotoxin, and has the properties of a local mediator of neutrophil recruitment into diseased tissues. There are indications that NAF/NAP-1 is important in the pathophysiology of inflammatory conditions such as psoriasis, idiopathic pulmonary fibrosis, asbestosis, adult respiratory distress syndrome and different forms of arthritis.
Baggiolini
M
M
Theodor-Kocher-Institut, Universität Bern.
Walz
A
A
D000595:Amino Acid Sequence; D002630:Chemotactic Factors / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D016209:Interleukin-8; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects*; D010452:Peptide Biosynthesis; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology*
D002630:Chemotactic Factors; D016209:Interleukin-8; D010455:Peptides
NAF/NAP-1, ein neues Peptid, das neutrophile Leukozyten aktiviert.