Growing human B-cell precursors in vitro: the continuing challenge.
Methods for propagating murine B-cell precursors in vitro have been instrumental in unraveling the cells and molecules regulating murine B-cell ontogeny. However, similar methods are not available for studying human B-cell ontogeny. Here, Tucker LeBien discusses why efforts to grow human B-cell precursors in vitro have been largely unsuccessful and proposes alternative strategies that may prove useful.
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D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D002455:Cell Division; D002478:Cells, Cultured; D006801:Humans; D008722:Methods; D013234:Stem Cells / Q000166:cytology