Effect of endothelin as a coronary vasoconstrictor in the Langendorff-perfused rat heart.
The effects of endothelin on coronary circulation were studied in isolated rat heart using a constant-flow system. Endothelin (10 fmol to 20 pmol/g heart weight) elevated the coronary perfusion pressure in a dose-dependent manner. Nifedipine (100 nM) inhibited the vasoconstriction and shifted the dose-response curve to the right. These results indicate that endothelin is a potent coronary vasoconstrictor and that its action is possibly mediated by the nifedipine-dependent Ca2+ channel.
Fukuda
K
K
Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Hori
S
S
Kusuhara
M
M
Satoh
T
T
Kyotani
S
S
Handa
S
S
Nakamura
Y
Y
Oono
H
H
Yamaguchi
K
K
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016232:Endothelins; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D014661:Vasoconstriction / Q000187:drug effects*
D002121:Calcium Channel Blockers; D016232:Endothelins; D010455:Peptides; D009543:Nifedipine