Non-neurogenic stimulation of adrenomedullary secretion during endotoxicosis in the one day old rat.
In both newborn and twenty day old rats, bacterial (S. enteritidis) endotoxin caused a marked decrease in adrenal epinephrine and norepinephrine. Catecholamine release was prevented by ganglionic blockade in 20 day old, but not 1 day old animals, indicating that the release in the neonatal rat is "non-neurogenic." The amount released was physiologically significant: equivalent to 20 micrograms/kg by i.v. administration. Two possible mechanism known to promote non-neurogenic secretion are hypoxia or histamine release, both of which can occur during endotoxicosis.
Seidler
F J
FJ
Dept. of Pharmacology, Duke University Medical Center, Durham, NC 27710.
Mills
E
E
D000313:Adrenal Medulla / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002714:Chlorisondamine / Q000494:pharmacology; D004731:Endotoxins / Q000633:toxicity*; D004837:Epinephrine / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012477:Salmonella enteritidis
D004731:Endotoxins; D002714:Chlorisondamine; D009638:Norepinephrine; D004837:Epinephrine