title: Primary cutaneous follicular centre-cell lymphoma--a lymphoproliferative disease with favourable prognosis.
abstract: In this study the clinico-pathological and immuno-histological features, the methods of treatment and follow-up data of 11 patients with follicular centre-cell (B-cell) lymphoma primarily presenting in the skin are reported. All the patients had nodular, tumorous and/or papulonodular skin lesions on the trunk. In nine patients the disease was confined to a circumscribed area of the back. Small papulonodular or plaque-like lesions, as well as large nodules or tumours, were biopsied in six of 11 patients. No clear-cut correlation between the age and clinical morphology of the lesions and their histological growth pattern was found. Interestingly, however, a different immuno-architectural pattern was observed in large, late lesions compared to small, early lesions. Initial treatment consisted of orthovolt radiotherapy (in two patients associated with surgical excision), resulting in complete remission in all patients. Only one patient developed extracutaneous disease, which was limited to a single drainage lymph node appearing simultaneously with a cutaneous relapse. Five other patients had recurrent disease in the skin close to the initial site. The median disease-free period was 15.5 months. On relapse, radiotherapy alone or in combination with short courses of chemotherapy was performed. This resulted in a second complete remission. All the patients are still alive and in complete remission, with a median survival of 37 months. These results confirm the favourable prognosis of patients affected with primary cutaneous follicular centre-cell lymphoma limited to the trunk. Orthovolt radiotherapy proved to be the most suitable treatment for both initial lesions and relapses limited to the skin.
authors.forename: N
authors.initials: N
authors.lastname: Pimpinelli
authors.forename: M
authors.initials: M
authors.lastname: Santucci
authors.forename: A
authors.initials: A
authors.lastname: Bosi
authors.forename: S
authors.initials: S
authors.lastname: Moretti
authors.forename: C
authors.initials: C
authors.lastname: Vallecchi
authors.forename: A
authors.initials: A
authors.lastname: Messori
authors.forename: B
authors.initials: B
authors.lastname: Giannotti
mesh_terms: D003131:Combined Modality Therapy; D006801:Humans; D008224:Lymphoma, Follicular / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology* / Q000628:therapy