Evidence for a sex chromosome locus for schizophrenia.
The sex chromosomes are strong candidates for a genetic locus for schizophrenia and the affective psychoses. Gender differences in the clinical expression of illness and familial risks, concordance for gender and illness in relatives, and an association of X chromosome anomalies with psychosis suggest an X chromosome locus. The presence of male-to-male transmission in some families, in the face of a lack of strong evidence for heterogeneity, specifically focuses the search within the pseudoautosomal region of the X and Y chromosomes where sequence homology and recombination takes place.
DeLisi
L E
LE
Dept. of Psychiatry, SUNY, Stony Brook 11974.
Crow
T J
TJ
D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000150:complications / Q000235:genetics*; D012729:Sex Chromosome Aberrations / Q000235:genetics; D012730:Sex Chromosomes; D014960:X Chromosome