title: Immunoglobulin therapy in neurologic diseases.
abstract: An overview is given on the use of immunoglobulins in clinical neurology. While 5S-immunoglobulins may be employed in addition to virostatics in viral encephalitis, 7S-immunoglobulins can be used in autoimmune diseases like myasthenia gravis, multiple sclerosis, and the Guillain-Barré syndrome. Refractory childhood epilepsies like the Lennox-Gastaut syndrome responded to 7S-immunoglobulins. Hyperimmunoglobulins are to be given in bacterial infections in which toxins are formed and in viral infections caused by cytomegalovirus and tick-borne encephalitis virus. While some open studies report benefit from the use of immunoglobulins in neurological diseases, controlled evidence for their efficacy is still missing.
authors.affiliation: Neurologische Klinik im Klinikum Mannheim der Universität Heidelberg.
authors.forename: P
authors.initials: P
authors.lastname: Berlit
mesh_terms: D001327:Autoimmune Diseases / Q000628:therapy; D001424:Bacterial Infections / Q000628:therapy; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D007128:Immunoglobulin Fragments / Q000627:therapeutic use; D009422:Nervous System Diseases / Q000628:therapy*; D014777:Virus Diseases / Q000628:therapy
chemical_list: D007128:Immunoglobulin Fragments