[A double-blind randomized comparative study of iopromide and amidotrizoate in the angiocardiography of infants and young children with congenital heart defects].
For 50 sucklings and small infants with cyanotic and acyanotic heart defects the non-ionic contrast medium Iopromide was tested against the ionic contrast medium Amidotrizoate in angiography. With consideration to the applied method the tested cardiospecific enzymes (CK MB, alpha-HBDH, lactate) as well as hematocrit, oxygen content of central venous blood, heart rate, systolic pressures in both ventricles and ECG showed no significant differences. The different end-diastolic pressures in both ventricles and the average pressure in the right atrium, however, showed the cardiotoxicity of Amidotrizoate. Conclusively the use of Iopromide is demanded for infants, small infants and sucklings.
Gliech
V
V
Göldner
B
B
Gola
G
G
Münster
W
W
Kothe
K
K
D000790:Angiocardiography; D003973:Diatrizoate; D004311:Double-Blind Method; D005260:Female; D006321:Heart / Q000187:drug effects*; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007472:Iohexol / Q000031:analogs & derivatives; D008297:Male; D016032:Randomized Controlled Trials as Topic
D003973:Diatrizoate; D007472:Iohexol; C038192:iopromide
Doppelblinde randomisierte Vergleichsstudie von Iopromid und Amidotrizoat bei Angiokardiografie von Säuglingen und Kleinkindern mit konnatalen Herzfehlern.