title: Crystal structure determination of 4-zinc bovine insulin at 1.9 A resolution.
abstract: With the isomorphous difference Fourier method and the restrained least-squares refinement technique, the crystal structure of 4-zinc bovine insulin in space group R3 was determined. The final crystallographic residual is 0.19 at 1.9 A resolution. Based on the refined model, the structural mechanism for prolonged action of 4-zinc insulin is discussed.
authors.affiliation: Institute of Biophysics, Academia Sinica, Beijing, PRC.
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.forename: D C
authors.initials: DC
authors.lastname: Wang
authors.forename: D C
authors.initials: DC
authors.lastname: Liang
mesh_terms: D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D003460:Crystallization; D003692:Delayed-Action Preparations; D007328:Insulin / Q000032:analysis*; D008968:Molecular Conformation; D015032:Zinc / Q000032:analysis*
chemical_list: D003692:Delayed-Action Preparations; D007328:Insulin; D015032:Zinc