Postischemic mechanical and vascular dysfunction (myocardial "stunning" and microvascular "stunning") and the effects of calcium-channel blockers on ischemia/reperfusion injury.
The purpose of this review is to summarize current concepts regarding the sequelae of myocardial ischemia and reperfusion and the effects of calcium-channel blockers. This article will focus on three topics: (1) the phenomenon of postischemic myocardial dysfunction (myocardial "stunning"); (2) the phenomenon of postischemic vascular dysfunction (microvascular "stunning"); (3) the effects of calcium-channel blockers on myocardial ischemia and reperfusion injury.
Bolli
R
R
Experimental Animal Laboratory, Section of Cardiology, Baylor College of Medicine, Houston, Texas 77030.
Triana
F
F
Jeroudi
M O
MO
D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003326:Coronary Circulation / Q000502:physiology*; D004285:Dogs; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology*; D009203:Myocardial Infarction / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000503:physiopathology
D002121:Calcium Channel Blockers