title: c-myc oncogene expression and clinical outcome in carcinoma of the cervix.
abstract: The expression of the c-myc oncogene was studied in paraffin-embedded specimens of cervical biopsies using a monoclonal antibody which binds to the 62,000 Dalton protein encoded by the c-myc gene. A range of cervical cancers from intraepithelial neoplasia to advanced grade IV tumours were studied together with normal cervical biopsies; c-myc status was correlated to clinical progress. There was no correlation seen between the clinical stage of the disease at presentation and c-myc expression. The 15 patients with c-myc negative cervical cancers were shown to have better disease free (mean--95.4 mos) and total survival (mean 118.0--mos) compared to the 16 patients that were c-myc positive 28.4 and 48.4 mos respectively). The pattern of recurrence differed between the two groups with c-myc positive tumours more likely to develop extra pelvic metastatic disease. The c-myc status of cervical cancer offers a prognostic indicator that could be useful in guiding treatment decisions.
authors.affiliation: Department of Clinical Oncology, Hammersmith Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Sowani
authors.forename: G
authors.initials: G
authors.lastname: Ong
authors.forename: S
authors.initials: S
authors.lastname: Dische
authors.forename: C
authors.initials: C
authors.lastname: Quinn
authors.forename: J
authors.initials: J
authors.lastname: White
authors.forename: P
authors.initials: P
authors.lastname: Soutter
authors.forename: J
authors.initials: J
authors.lastname: Waxman
authors.forename: K
authors.initials: K
authors.lastname: Sikora
mesh_terms: D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc