Pathogenesis and pathology of graft-vs.-host disease.
Over the past decade, there has been a significant increase in the number of patients with a variety of malignant and nonmalignant disorders referred for bone marrow transplantation. Despite numerous advances in the care of such patients after allogeneic bone marrow transplantation, acute and chronic graft-vs.-host disease continues to be a principal cause of morbidity and mortality. In this article, we will present an overview of the pathogenesis, clinical presentation, and pathological manifestations of these two major complications.
Wagner
J E
JE
Department of Oncology and Pediatrics, Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, MD 21205.
Vogelsang
G B
GB
Beschorner
W E
WE
D000208:Acute Disease; D016026:Bone Marrow Transplantation; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D006801:Humans