Intracellular traffic of secreted peptides--a morphological point of view.
Secretory proteins follow an intracellular pathway, from their site of synthesis inside the cell to their site of release at the cell surface, within several membrane-bound compartments. Along this route, other exported proteins and membrane proteins travel to their final extracellular or intracellular destination, which implies sorting mechanisms. Morphological observations, performed in our laboratory on normal and tumoral pituitary prolactin cells in culture as well as studies from others on ACTH- and insulin-secreting cells, will be reviewed.
Tougard
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Groupe de Neuroendocrinologie Cellulaire et Moléculaire, Collège de France, URA CNRS 1115, Paris.
D000818:Animals; D006728:Hormones / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007425:Intracellular Membranes / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology; D010455:Peptides / Q000378:metabolism* / Q000502:physiology
D006728:Hormones; D008565:Membrane Proteins; D010455:Peptides