[Systemic lupus and pregnancy. General review].
The obstetrician is concerned with disseminated lupus because it is a relatively common illness which particularly affects women of reproductive age. This article reviews the literature in order to try to find an answer to the question: what effect pregnancy has on lupus and lupus on pregnancy. As far as the mother is concerned, pregnancy does not seem to increase the likelihood of relapse. Those women are most in danger who had renal disease before the pregnancy and still more if the renal lesions were active at the time of conception. There is no place any more for therapeutic termination of pregnancy nor probably for systematic treatment with cortisone. The prognosis for the fetus is more serious and does not depend on the maternal state. Fetal loss seems to be of the order of 40%, particularly due to non-specific complications of the illness. Neonatal lupus is linked to the presence of anti-Ro antibodies and to a particular HLA type. Finally, the criteria to be observed for looking after the mother and fetus are summarised.
Nizard
V
V
Hôpital International de l'Université de Paris.
D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D011247:Pregnancy; D011248:Pregnancy Complications
Lupus systémique et grossesse. Revue générale.