title: Renal transplantation is not contraindicated in asymptomatic carriers of hepatitis B surface antigen.
abstract: Recent reports showing that the presence of positive tests for hepatitis B surface antigen (HBsAg) is associated with prohibitively high morbidity and mortality suggest that such patients should not be considered for kidney transplantation. The clinical outcome and serology including hepatitis B DNA assays of 11 patients who were HBsAg-positive at the time of transplantation, as well as the hepatic complications in all 200 kidney transplantations during the same period, were analyzed. In the 11 HBsAg-positive patients, no clinical or laboratory evidence suggesting deterioration in liver function over a mean follow-up period of 8.0 +/- 1.7 years was found. Of six patients with fatal or severe chronic liver disease, only one was HBsAg-positive at the time of transplantation and showed no deterioration over 9 years. Two immunosuppressed patients developed anti-HBs antibodies after acute hepatitis B infection. A review of the literature leads to the conclusion that previous reports of poor patient prognosis may represent patients who first showed HBsAg positivity after transplantation or who had preexisting HBsAg-related liver disease. The present findings suggest that asymptomatic patients with positive tests for HBsAg should not be excluded from kidney transplantation programs.
authors.affiliation: Nephrology Service, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: M M
authors.initials: MM
authors.lastname: Friedlaender
authors.forename: R T
authors.initials: RT
authors.lastname: Kaspa
authors.forename: D
authors.initials: D
authors.lastname: Rubinger
authors.forename: J
authors.initials: J
authors.lastname: Silver
authors.forename: M M
authors.initials: MM
authors.lastname: Popovtzer
mesh_terms: D000328:Adult; D002353:Carrier State; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000150:complications*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D012189:Retrospective Studies
chemical_list: D006514:Hepatitis B Surface Antigens