[The use of human insulin in cases of insulin allergy].
The authors treated 14 insulin-allergic diabetic patients in 1985-87. Previous short-term therapy with conventional insulins could be verified in 12 cases. The "presensitizing" effect of this transient treatment seems highly probable. Five of the 14 patients were allergic to all animal insulins incl. monospecies porcine monocomponent (MC) preparations. Surprisingly, all these patients proved to be allergic to biosynthetic human insulin (Huminsulin Normal and Huminsulin Basal) preparations too, but two of them could be treated with semisynthetic human insulins (Actrapid HM and Monotard HM). Another patient was able to receive Monotard HM exclusively. The remaining two patients proved to be allergic to all human insulins used. One of them was desensitized but the insulin therapy had to be supplemented with steroid drugs for two years. The fifth patient continued the oral treatment but her metabolism is poorly controlled. These results show that some diabetics with allergy to animal insulins are allergic to human insulins as well. As a prevention, transient therapy with conventional preparations should be avoided. If, however, there is an absolute indication for it (e.g. gestational diabetes or surgical intervention), it should be carried out with human insulin, or, if that is not available, with monospecies porcine MC insulin.
Gerö
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Kerényi
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Bányai
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Tamás
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D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D061389:Insulin, Regular, Pork
D007004:Hypoglycemic Agents; D007328:Insulin; D061389:Insulin, Regular, Pork; C000006:insulin, neutral
Humán insulin alkalmazása insulin-allergia eseteiben.