[Treatment of somatotropic deficiency with biosynthetic growth hormone].
A total of 21 patients with somatotropic deficiency have been enrolled in a clinical trial of biosynthetic growth hormone (bio-GH) and pituitary growth hormone (pit-GH). Five of them not previously treated (naïve) and 7 previously treated with pit-GH, received bio-GH; 9 received only pit-GH. Biosynthetic-GH was given 12 UI/m2/week. Height velocities during treatment rose, for naïve patients, from 3.6 +/- 0.3 cm/year (before treatment) to 8.7 +/- 1.3 cm/year (after 12 months treatment). For previously treated patients, after a period at least 6 months without any GH therapy, the increase in height was from 2.5 +/- 0.9 cm/year to 6.8 cm/year; and for the patients who received only pit-GH was from 3.4 +/- 1.2 cm/year to 8.0 +/- 1.1 cm/year. No significant difference was observed between the growth velocities obtained with the two preparations. No specific side-effects were noted.
Spagnoli
A
A
Clinica Pediatrica II Università di Roma Tor Vergata, Italia.
Bernardini
S
S
Galasso
C
C
Vaccaro
F
F
Manca Bitti
M L
ML
Scirè
G
G
Cianfarani
S
S
Spadoni
G L
GL
D000293:Adolescent; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy*; D013006:Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male
D006728:Hormones; D013006:Growth Hormone
Trattamento dell'insufficienza somatotropinica con ormone della crescita biosintetico.