title: Fructose is as good a fuel as glucose for exercise in normal subjects.
abstract: 50 g fructose and 50 g glucose loads, naturally 13C labelled, were orally administered in random order to six healthy subjects submitted to 90 mn exercise at VO2 max/2 on a treadmill. 13CO2/12CO2 variations in the expired air were followed before and after exercise for a total of 240 min. On the whole, fructose appeared to be as good a fuel as glucose during exercise even if slight but significant differences in kinetics were observed: the delta 13C peak values at 90 min were significantly lower with fructose. Between 90 and 240 min, delta 13C remained higher but not significantly with 13C-fructose than with 13C-glucose. During exercise, plasma glucose and insulin levels were significantly lower (p less than 0.05 and p less than 0.01) after fructose than after glucose. We conclude that fructose can be readily used during exercise by healthy subjects.
authors.affiliation: Department of diabetes, Hôtel-Dieu Hospital, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Slama
authors.forename: J
authors.initials: J
authors.lastname: Boillot
authors.forename: I
authors.initials: I
authors.lastname: Hellal
authors.forename: D
authors.initials: D
authors.lastname: Darmaun
authors.forename: S W
authors.initials: SW
authors.lastname: Rizkalla
authors.forename: E
authors.initials: E
authors.lastname: Orvoen-Frija
authors.forename: M F
authors.initials: MF
authors.lastname: Dore
authors.forename: G
authors.initials: G
authors.lastname: Guille
authors.forename: J
authors.initials: J
authors.lastname: Fretault
authors.forename: J
authors.initials: J
authors.lastname: Coursaget
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002247:Carbon Isotopes; D004040:Dietary Carbohydrates / Q000378:metabolism*; D004734:Energy Metabolism; D005260:Female; D005632:Fructose / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D005082:Physical Exertion; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D002247:Carbon Isotopes; D004040:Dietary Carbohydrates; D007328:Insulin; D005632:Fructose; D005947:Glucose