Nobel Lecture. The purine path to chemotherapy.
Antimetabolites of purine metabolism have found a use as anti-leukaemic, antiprotozoal and antiviral drugs, in immunosuppression and transplantation, and in gout and hyperuricemia. Their mechanisms of action are reviewed.
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Wellcome Research Laboratories, Burroughs Wellcome Co., Research Triangle Park, NC 27709.
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000963:Antimetabolites / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004358:Drug Therapy; D049673:History, 20th Century; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007938:Leukemia / Q000188:drug therapy; D011687:Purines / Q000266:history / Q000378:metabolism* / Q000627:therapeutic use
D000890:Anti-Infective Agents; D000963:Antimetabolites; D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D011687:Purines