title: Efficacy, safety, and tolerability of ioversol in intra-arterial digital subtraction angiography.
abstract: Twenty-two women and 18 men undergoing intra-arterial digital subtraction angiography were enrolled in an open-label, noncomparative study to assess the efficacy, safety, and patient tolerance of the contrast medium ioversol. The quality of radiographs generated was excellent in 60.0% of the studies, diagnostic in 37.5%, and nondiagnostic in 2.5%. There were no clinically significant drug-related changes in vital signs or laboratory tests among the patients, and no drug-related adverse effects were reported. Heat and pain related to injection of ioversol were graded on a four-point scale, with 0 indicating none and 3 indicating severe. The average scores were 1.3 for heat and 0.1 for pain. In this study, ioversol was a safe and effective contrast medium for angiography and was associated with a low incidence of patient discomfort.
authors.affiliation: Department of Radiology, University of Utah Medical Center, Salt Lake City 84132.
authors.forename: F J
authors.initials: FJ
authors.lastname: Miller
authors.forename: S R
authors.initials: SR
authors.lastname: Pollei
authors.forename: A G
authors.initials: AG
authors.lastname: Osborn
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography / Q000379:methods; D001831:Body Temperature / Q000187:drug effects; D003287:Contrast Media; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D007463:Iodobenzoates; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D013382:Subtraction Technique; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000633:toxicity
chemical_list: D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; C054871:ioversol