[Hemodynamic effects of the treatment of hypertension with the calcium channel blocker diltiazem].
The 1.5-benzotthazepine derivative diltiazem, which blocks slow calcium channels, is an effective hypotensive agent, used for the treatment of moderate hypertension. Treatment with diltiazem alone, its dose adjusted on an individual basis, controlled arterial blood pressure in 58% of the patients. With a 240 mg daily dose, blood pressure was controlled in 12 of 52 patients; when the daily dose was increased to 360 mg, blood pressure was controlled in another 18 patients. In the remaining 22 patients, blood pressure was only controlled after captopril was added in a daily dose of at least 50 mg. The drop of arterial blood pressure was associated with falling total peripheral resistance and end diastolic blood volume, and was accompanied by an increase in left-ventricular ejection fraction and myocardial oxygen want.
Ivleva
A Ia
AIa
Moiseev
V S
VS
Lepakhin
V K
VK
Krasnobaeva
G M
GM
Ogoliuk
L Iu
LIu
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents; D002216:Captopril / Q000008:administration & dosage; D004110:Diltiazem / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D000959:Antihypertensive Agents; D002216:Captopril; D004110:Diltiazem
Gemodinamicheskie éffekty pri lechenii gipertonii blokatorom kal'tsevykh kanalov diltiazemom.