Treatment of 80 patients with Turner's syndrome with recombinant human growth hormone (YM-17798) for one year: the results of a multicentric study in Japan. Committee for the Treatment of Turner's Syndrome.
A total of 80 patients with Turner's syndrome were treated with methionine-free recombinant hGH (r-hGH) for one year. Thirty-nine patients were treated with r-hGH at weekly dosage of 0.5 IU/kg and forty-one were treated with 1.0 IU/kg/w by daily sc injection. Both treatment groups showed a statistically significant growth increase during the treatment from 3.7 +/- 1.0 to 6.0 +/- 1.1 and 7.2 +/- 1.3 (mean +/- SD) cm/year, respectively. Fifty-nine percent of the patients treated with 0.5 IU/kg/w and 87.8% of the patients treated with 1.0 IU/kg/w showed a growth rate more than 2 cm greater than the pretreatment values. Plasma somatomedin C levels were elevated and no remarkable advances in bone age were observed during the treatment in both treatment groups. An antibody against to hGH was observed in 6.8% of the patients. Otherwise, there were no significant changes in physical or laboratory examinations. No glucose intolerance was observed. These results indicate that hGH treatment is useful in accelerating growth velocity in patients with Turner's syndrome.
Takano
K
K
Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical College, Tokyo, Japan.
Shizume
K
K
Hibi
I
I
D000293:Adolescent; D000365:Age Determination by Skeleton; D000917:Antibody Formation; D002648:Child; D005260:Female; D005947:Glucose / Q000378:metabolism; D006128:Growth / Q000187:drug effects*; D013006:Growth Hormone / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D007564:Japan; D015337:Multicenter Studies as Topic; D011994:Recombinant Proteins / Q000276:immunology / Q000627:therapeutic use; D014424:Turner Syndrome / Q000188:drug therapy*
D011994:Recombinant Proteins; D013006:Growth Hormone; D005947:Glucose