Endotoxin shock in the rat: reduction of arterial blood pressure fall by the bradykinin antagonist B4148.
The selective competitive bradykinin (BK) antagonist (B4148) produced significant inhibition of the hypotensive effect of BK in rats. Using a rat model of endotoxin shock, the fall in mean arterial blood pressure to an intravenous injection of lipopolysaccharide from E. coli was significantly attenuated by the B4148 as compared to controls. These findings suggest that kinins are involved in the hypotensive response to endotoxin shock in rats. The development of potent BK antagonists offers a new experimental approach for evaluating the role of kinins in this and other disease states.
Weipert
J
J
Abteilung für Klinische Chemie und Klinische Biochemie, University of Munich, FRG.
Hoffmann
H
H
Siebeck
M
M
Whalley
E T
ET
D000818:Animals; D001920:Bradykinin / Q000037:antagonists & inhibitors*; D004926:Escherichia coli; D007022:Hypotension / Q000209:etiology / Q000517:prevention & control*; D007609:Kallidin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007700:Kinetics; D008070:Lipopolysaccharides; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology
D008070:Lipopolysaccharides; C056611:B 4148; D007609:Kallidin; D001920:Bradykinin