[Clinical effectiveness of cefoperazone for respiratory infections of elderly patients, focusing on its safety on renal function].
Clinical effectiveness of cefoperazone (CPZ) was studied for 46 elderly patients with respiratory infections. 1. Clinical efficacy rate of CPZ was 80.6% (29/36). 2. Adverse reactions occurred in 2 patients as systemic rush and fever. Laboratory abnormalities were observed in 5 patients. These included elevation of transaminase value. 3. The serum concentration of CPZ at 12 hours after administration of 2 g CPZ was not reflected in creatinine clearance and total bilirubin, and those 2 values appeared to have little effects on CPZ excretion. 4. The administration of CPZ at 4 g/day for less than 3 weeks had no effects on the renal function. As a result of this study, CPZ was found to have little undesirable effect on renal functions and to be a useful drug for the treatment of respiratory infections in elderly patients.
Tanimoto
H
H
Forth Department of Internal Medicine, Jikei University School of Medicine.
Suzuki
T
T
Sato
T
T
Hirota
Y
Y
Nagai
H
H
Yoneda
R
R
Matsuda
Y
Y
Morozumi
K
K
Kohno
N
N
Kuriyama
T
T
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001663:Bilirubin / Q000097:blood; D002438:Cefoperazone / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000503:physiopathology
D002438:Cefoperazone; D003404:Creatinine; D001663:Bilirubin