Renal transplantation using cyclosporine with and without regard to HLA matching: a randomized prospective unicenter study.
A randomized prospective unicenter study produced no significant difference in 2-year outcome between the use of well matched cadaver renal allografts shared among transplantation centers, and the use of organs of local origin matched only for blood group. Graft and patient survival rates, transplant function and incidence of rejection were compared. On the basis of 1 and 2-year outcome with well matched and shared allografts we conclude that cyclosporine therapy makes HLA matching unnecessary.
Harfmann
P
P
Department of Urology, University of Hamburg, Federal Republic of Germany.
Dittmer
R
R
Busch
R
R
Arndt
R
R
Krämer-Hansen
H
H
Huland
H
H
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003524:Cyclosporins / Q000627:therapeutic use*; D006085:Graft Survival; D006680:HLA Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D008875:Middle Aged; D009026:Mortality; D011183:Postoperative Complications; D011446:Prospective Studies; D011897:Random Allocation
D003524:Cyclosporins; D006680:HLA Antigens