T-cell malignancy following B-cell lymphoma in remission.
A T-cell malignancy developed in a 64-year-old man with recurrent B-cell lymphoma after one and a half years of remission. Immunophenotypic and DNA analyses confirmed clonality and cell lineage of both lymphoid malignancies. Sequential development of B- and T-cell malignancies in this patient may be an example of biclonal lymphoma or treatment-related secondary lymphoma. However, another possibility would be the existence of a transformed lymphoid stem cell that underwent intraclonal conversion from B- to T-cell lines.
Shimizu
K
K
Department of Medicine, Fujita Gakuen Health University, School of Medicine, Japan.
Hirano
M
M
Maruyama
F
F
Itoh
M
M
Hara
K
K
Ino
T
T
Ezaki
K
K
Kunii
A
A
D000914:Antibodies, Viral / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes; D004273:DNA, Neoplasm / Q000032:analysis; D015321:Gene Rearrangement; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D007158:Immunologic Techniques; D008223:Lymphoma / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010641:Phenotype; D012074:Remission Induction; D013601:T-Lymphocytes; D014062:Tongue Neoplasms / Q000473:pathology*
D000914:Antibodies, Viral; D004273:DNA, Neoplasm