title: Cytogenetics in patients with chronic myelogenous leukemia treated with bone marrow transplantation.
abstract: Cytogenetic data are reported from 16 patients with Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) treated with bone marrow transplantation (BMT). The usefulness of cytogenetic investigations for the assessment of marrow engraftment is stressed. The significance of persistence or reappearance of Ph after BMT, possibly due to a defective leukemic clone eradication by the conditioning regimen, is also discussed. Generally, Ph-positive cells are damaged and disappear within the first year of BMT. Sometimes, however, the cells may repair the damage and proliferate again, resulting in disease relapse. Rarely, clinical and hematologic relapse does not follow Ph-positive clone expansion although leukemic cells represent more than 50% of marrow metaphases examined. Finally, the effect of interferon on Ph-positive clones after BMT and random chromosome changes, that appear transiently after BMT and are of uncertain significance, are discussed.
authors.affiliation: University of Chieti, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Calabrese
authors.forename: P
authors.initials: P
authors.lastname: Di Bartolomeo
authors.forename: L
authors.initials: L
authors.lastname: Stuppia
authors.forename: P
authors.initials: P
authors.lastname: Guanciali Franchi
authors.forename: G
authors.initials: G
authors.lastname: Parruti
authors.forename: M
authors.initials: M
authors.lastname: Ciancarelli
authors.forename: F
authors.initials: F
authors.lastname: Angrilli
authors.forename: L
authors.initials: L
authors.lastname: Geraci
authors.forename: G
authors.initials: G
authors.lastname: Palka
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D006085:Graft Survival; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012008:Recurrence