title: Interleukin 2 as an inducer of proliferation in Klebsiella-stimulated human B cells.
abstract: Klebsiella membranes (KLEBS M), a membrane preparation from Klebsiella pneumoniae, acts as a T-cell independent polyclonal B-cell activator (PBA), stimulating B cells to mature into Ig-secreting cells without prior proliferation. The KLEBS M-activated B cells express Tac antigen. Recombinant interleukin 2, used in costimulation with KLEBS M, induces proliferation and increases the Ig secretion of B cells. On the other hand, KLEBS M-activated B cells do not respond to human BCGF. The lack of proliferation in KLEBS M-stimulated mononuclear cells is shown to be due to the inability of this PBA to induce the production of interleukin 2 in T cells.
authors.affiliation: I. Medizinische Universitätsklinik, Kiel, Federal Republic of Germany.
authors.forename: F
authors.initials: F
authors.lastname: Stüber
authors.forename: M
authors.initials: M
authors.lastname: Ernst
authors.forename: H D
authors.initials: HD
authors.lastname: Flad
authors.forename: W L
authors.initials: WL
authors.lastname: Gross
mesh_terms: D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D015847:Interleukin-4; D007378:Interleukins / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000276:immunology*; D008213:Lymphocyte Activation; D011994:Recombinant Proteins / Q000494:pharmacology; D012397:Rosette Formation
chemical_list: D007376:Interleukin-2; D007378:Interleukins; D011994:Recombinant Proteins; D015847:Interleukin-4