Primary cerebral neuroblastoma (neurocytoma) in adults.
We report a case of a third ventricular neuroblastoma (neurocytoma) in a 66 year old man. A stereotactic needly biopsy was performed to obtain a tissue diagnosis and was followed by total resection. We elected not to give radiation or chemotherapy and to follow the patient closely with serial CT scans. Presently, 48 months postoperatively, the patient is free of tumor by head CT scan and able to live independently. We reviewed the literature of primary cerebral neuroblastomas/neurocytomas occurring in adults (greater than or equal to 15 years of age) and found 32 cases. Our patient is the oldest of this group with a mean age of 32 +/- 14 years (S.D.). The location of the 33 neoplasms was intraventricular in 17 cases (52%) and intraparenchymal in 16 cases. The male to female ratio was 2:1. Of the 17 patients having a minimal follow-up period of 5 months (mean 51 months), five developed recurrences after 5 to 144 months (mean 50 months) compared to 12 patients without recurrence after a 6- to 72-month follow-up period (mean 52 months). Recurrences occurred statistically significantly more often in parenchymal neuroblastomas/neurocytomas than in intraventricular tumor locations.
Ferreol
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University of Cincinnati, College of Medicine Department of Pathology, Ohio 45267-0533.
Sawaya
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de Courten-Myers
G M
GM
D000368:Aged; D001706:Biopsy; D002551:Cerebral Ventricle Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D009447:Neuroblastoma / Q000473:pathology* / Q000648:ultrastructure