Chloroquine resistance in Plasmodium falciparum in KwaZulu, 1983-1988.
Patients with Plasmodium falciparum infections in northern KwaZulu adjacent to the Mozambique border were treated with chloroquine 25 mg/kg. Persistent parasitaemias increased from nil in 1983 to 21.2% and 16.1% for hospital and field treatments respectively in 1987. After a change to sulfadoxine-pyrimethamine (Fansidar; Roche) treatment (adults 1,500 mg and 75 mg respectively) these rates fell in March 1988 to 6.9% and 0.4%.
Hansford
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Department of National Health and Population Development, Tzaneen, Tvl.
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D002738:Chloroquine / Q000494:pharmacology / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D004351:Drug Resistance; D008288:Malaria / Q000188:drug therapy*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000627:therapeutic use*; D013019:South Africa; D013413:Sulfadoxine / Q000627:therapeutic use*; D013424:Sulfanilamides / Q000627:therapeutic use*
D000962:Antimalarials; D004338:Drug Combinations; D013424:Sulfanilamides; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D002738:Chloroquine; D011739:Pyrimethamine