title: Mitochondrial RNA polymerase: dual role in transcription and replication.
abstract: Mitochondrial RNA polymerases from humans, Xenopus laevis and Saccharomyces cerevisiae are very similar in protein composition and function. They consist of a nonspecific core RNA polymerase and a protein factor that confers promoter selectivity on the core component, and they participate in transcription as well as in DNA replication. Amino acid sequence comparisons indicate that the yeast mitochondrial core component is related to bacteriophage T3 and T7 RNA polymerases; mitochondrial and phage polymerases may therefore belong to a family of related polymerases.
authors.forename: A H
authors.initials: AH
authors.lastname: Schinkel
authors.forename: H F
authors.initials: HF
authors.lastname: Tabak
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004261:DNA Replication; D004272:DNA, Mitochondrial / Q000096:biosynthesis* / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000201:enzymology*; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
chemical_list: D004272:DNA, Mitochondrial; D012321:DNA-Directed RNA Polymerases