Influence of carrageenan on peritoneal macrophages.
BALB/c mice were given five intraperitoneal (i.p.) injections of lambda carrageenan (CGN lambda). Following this treatment, the viability, phagocytic capacity, bactericidal activity, interleukin 1 (IL-1)-producing ability and Ia+ cell content of the peritoneal plastic-adherent macrophage population was analysed. The present study demonstrates the enhancement of bactericidal activity, inhibition of the augmented Ia+ cell content after priming with sheep red blood cells (SRBC), and impairment of IL-1 production by peritoneal macrophages, although their viability and phagocytic function remained unaltered.
Vijayakumar
R K
RK
Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, India.
Palanivel
V
V
Muthukkaruppan
V R
VR
D000818:Animals; D002351:Carrageenan / Q000494:pharmacology*; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D007165:Immunosuppression Therapy; D007375:Interleukin-1 / Q000096:biosynthesis; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010529:Peritoneal Cavity / Q000166:cytology; D010587:Phagocytosis; D012486:Salmonella typhimurium / Q000276:immunology
D000949:Histocompatibility Antigens Class II; D007375:Interleukin-1; D002351:Carrageenan