Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production.
Effects of transforming growth factor beta (TGF-beta) on IgA production by LPS-stimulated B cells have been studied. TGF-beta itself could augment polyclonal IgA production in concomitant inhibition of polyclonal IgM and IgG1 production. Furthermore, TGF-beta and IL-5 additively augmented IgA production. TGF-beta exerted its activity early in the culture (by 2 d in a 5-d culture) and IL-5 was required late in the culture. Surface IgA- (sIgA-) B cells responded to TGF-beta for the development of IgA-secreting cells. By contrast, sIgA+ B cells, but not sIgA- B cells, responded to IL-5 for IgA production. These results suggest that TGF-beta has a differential role in the induction of IgA production from IL-5 on murine-activated B cells.
Sonoda
E
E
Department of Biology, Kumamoto University Medical School, Japan.
Matsumoto
R
R
Hitoshi
Y
Y
Ishii
T
T
Sugimoto
M
M
Araki
S
S
Tominaga
A
A
Yamaguchi
N
N
Takatsu
K
K
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007158:Immunologic Techniques; D015848:Interleukin-5 / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D015291:Transforming Growth Factors / Q000494:pharmacology*
D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015848:Interleukin-5; D008070:Lipopolysaccharides; D015291:Transforming Growth Factors