title: Ciclosporin A inhibits endothelium-dependent vasodilatation and vascular prostacyclin production.
abstract: Aortic rings dissected from rats treated with ciclosporin A (30 mg/kg per day for five days) showed reduced relaxation induced by the endothelium-dependent vasodilator acetylcholine, but unchanged responses induced by glyceryl trinitrate. After eight weeks of ciclosporin A treatment, the relaxation induced by both acetylcholine and glyceryl trinitrate was inhibited. In addition, phenylephrine-induced contractions were slightly enhanced and vascular prostacyclin production was reduced by more than 80%. These effects may participate in the hypertensive and thrombo-embolic complications associated with the clinical use of ciclosporin A.
authors.affiliation: Department of Cardiology, German Heart Institute Berlin.
authors.forename: C
authors.initials: C
authors.lastname: Bossaller
authors.forename: U
authors.initials: U
authors.lastname: Förstermann
authors.forename: R
authors.initials: R
authors.lastname: Hertel
authors.forename: C
authors.initials: C
authors.lastname: Olbricht
authors.forename: V
authors.initials: V
authors.lastname: Reschke
authors.forename: E
authors.initials: E
authors.lastname: Fleck
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D003524:Cyclosporins / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000502:physiology*; D011464:Epoprostenol / Q000096:biosynthesis*; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D003524:Cyclosporins; D010656:Phenylephrine; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol; D000109:Acetylcholine