Effect of insulin on the production of interleukin 2 by T lymphocytes.
The effect of insulin on interleukin 2 (IL-2) production was investigated. The results showed that insulin alone did not stimulate the resting T lymphocytes to produce IL-2, but enhanced the production of IL-2 by T lymphocytes and interleukin 1 (IL-1) by macrophages in the presence of lectin. Insulin augmented the response of T lymphocytes to IL-1 in the presence of Con A. The peak time of IL-2 production was not affected by insulin.
Luo
Y
Y
Feng
Z H
ZH
Wang
R D
RD
Chen
Z C
ZC
D000818:Animals; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis*; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000378:metabolism*
D007328:Insulin; D007375:Interleukin-1; D007376:Interleukin-2