title: Intrauterine resuscitation with tocolysis. An alternate month clinical trial.
abstract: Fifty patients were compared for the purpose of investigating the usefulness of intrauterine resuscitation with tocolysis (IURT). Terbutaline was given, as an intravenous bolus, to 31 women in labor in whom fetal distress was diagnosed and urgent delivery by cesarean section was indicated. In alternate months, a control group of 19 women with similar diagnoses was urgently delivered after standard interventions such as maternal positioning, oxygen administration, hydration, and discontinuation of oxytocin. Improvement in perinatal outcome was shown in infants after IURT. Apgar scores were less than 7 in 42% of the study group and in 71% of the control group at 1 minute (P = .04). Five-minute Apgar scores less than 7 occurred in 7% of the study group and 24% of the control group. A low venous pH was seen in 55% of the control group compared with 29% of the infants resuscitated with terbutaline. Estimated maternal blood loss and hematocrit change was not different in the two groups. Maternal blood pressure and pulse changes following IURT were modest and of doubtful significance. We conclude that intravenous terbutaline administered as a bolus injection at the time of fetal distress in labor improves infant outcome as evidenced by more vigorous Apgar scores and less acidemia without significant adverse physiologic effects on the mother.
authors.affiliation: Department of Obstetrics and Gynecology, Denver General Hospital, CO.
authors.forename: M S
authors.initials: MS
authors.lastname: Burke
authors.forename: R P
authors.initials: RP
authors.lastname: Porreco
authors.forename: D
authors.initials: D
authors.lastname: Day
authors.forename: J D
authors.initials: JD
authors.lastname: Watson
authors.forename: A D
authors.initials: AD
authors.lastname: Haverkamp
authors.forename: M
authors.initials: M
authors.lastname: Orleans
authors.forename: D
authors.initials: D
authors.lastname: Luckey
mesh_terms: D002986:Clinical Trials as Topic; D005260:Female; D005316:Fetal Distress / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007744:Obstetric Labor Complications / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D011247:Pregnancy; D011446:Prospective Studies; D013726:Terbutaline / Q000627:therapeutic use*; D015145:Tocolysis
chemical_list: D013726:Terbutaline