Childhood Ki-1 lymphoma. A report of two cases.
Two cases of childhood Ki-1 lymphoma occurred with the expression of Ki-1+/HLA-DR+/IL-2R+/EMA+/Leu-M1-/pan-T antigens-/pan-B antigens- in neoplastic cells. Patient 1 with nodular skin lesions expressed Leu-2a+ in the neoplastic cells and died 14 months later. Patient 2 with lymph node swelling and hepatosplenomegaly exhibited Leu-3a+ in the neoplastic cells and remains free of disease. The Leu-2a+ (case 1) or Leu-3a+ (case 2) findings suggest that the neoplastic cells in both cases were derived from T-lymphocyte lineage. However, Southern's blot analysis did not reveal any clonal rearrangements of T-cell receptor genes in the autopsy material from case 1. The Leu-3a+/Mcs-2+ finding in case 2 may indicate that the neoplastic cells were derived from monocyte/macrophage lineage.
Oka
K
K
Section of Clinical Laboratory, National Institute of Radiological Sciences Hospital, Chiba, Japan.
Mori
N
N
Kojima
M
M
Iijima
T
T
Hanada
T
T
Tsuchida
M
M
D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D054747:Histiocytic Sarcoma / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000473:pathology*; D008297:Male; D010641:Phenotype