title: Bronchial responsiveness to exercise after human cardiopulmonary transplantation.
abstract: Heart-lung transplant (HLT) recipients characteristically display marked bronchial hyperresponsiveness (BHR) to inhaled methacholine, but their bronchial responsiveness (BR) to exercise has not been reported. We measured BR to exercise in 13 stable HLT recipients, 13 normal control (NC) subjects and 13 asthmatic patients (AS). All subjects exercised for eight minutes on a bicycle ergometer at a work level designed to obtain and maintain 80 percent maximum heart rate, or to tolerance. The postexercise fall in FEV1 was equivalent in the HLT group and the NC group (0 +/- 0.2 L vs 0 +/- 0.2 L:p = NS) in contrast to the AS group (-0.6 +/- 0.5 L:p less than 0.01). Stable HLT recipients do not exhibit BHR to exercise at tolerable work loads. This observation supports the hypothesis that BHR to methacholine after HLT is due to denervation hypersensitivity of muscarinic receptors rather than other causes.
authors.affiliation: Department of Medicine, Stanford University School of Medicine, CA.
authors.forename: A R
authors.initials: AR
authors.lastname: Glanville
authors.forename: G M
authors.initials: GM
authors.lastname: Gabb
authors.forename: J
authors.initials: J
authors.lastname: Theodore
authors.forename: E D
authors.initials: ED
authors.lastname: Robin
mesh_terms: D000293:Adolescent; D000328:Adult; D001250:Asthma, Exercise-Induced / Q000175:diagnosis; D001985:Bronchial Provocation Tests; D001986:Bronchial Spasm / Q000209:etiology*; D005080:Exercise Test; D005260:Female; D005541:Forced Expiratory Volume; D016027:Heart Transplantation; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds; D005082:Physical Exertion; D012123:Pulmonary Ventilation; D013997:Time Factors
chemical_list: D008688:Methacholine Compounds; D016210:Methacholine Chloride