title: Multistage models for carcinogenesis.
abstract: The multistage model is tested on several human and animal data sets. It fits in some cases but not in others. With human lung cancer data, there is a drop in risk for ex-smokers quite different from the predictions of the model. The results are not conclusive but are compatible with the view that the multistage model provides a family of curves that often fit cancer incidence data, but may not capture the underlying biological reality.
authors.affiliation: Statistics Department, University of California, Berkeley 94720.
authors.forename: D A
authors.initials: DA
authors.lastname: Freedman
authors.forename: W C
authors.initials: WC
authors.lastname: Navidi
mesh_terms: D000367:Age Factors; D000818:Animals; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology*; D012306:Risk; D012907:Smoking / Q000009:adverse effects; D013997:Time Factors