title: [Neutrophil dysfunction in chronic neutrophilic leukemia without rearrangements of bcr and immunoglobulin heavy chain genes].
abstract: A 67-year-old man was admitted to our hospital with abdominal distension due to hepatosplenomegaly. The peripheral blood revealed Hb content 6.5 g/dl, platelet count 4.7 x 10(4)/microliter, and WBC count 105.8 x 10(3)/microliter with 88% of mature neutrophils. The neutrophil alkaline phosphatase score was 421. Bone marrow aspiration revealed hypercellularity with increased megakaryocytes and myeloid hyperplasia. 46, XY, del 20(q 11) without Philadelphia chromosome was identified by cytogenetic study. The patient was diagnosed as having chronic neutrophilic leukemia and was successfully treated with busulfan, but he died of atypical mycobacteriosis about 20 months later. Analysis of neutrophil function demonstrated diminution of deformability, random mobility, and chemotaxis, but almost normal phagocytosis and bactericidal capacity. Southern analysis showed no rearrangements of breakpoint cluster region (bcr) gene and immunoglobulin heavy chain gene.
authors.forename: S
authors.initials: S
authors.lastname: Okada
authors.forename: Y
authors.initials: Y
authors.lastname: Miyoshi
authors.forename: Y
authors.initials: Y
authors.lastname: Takizawa
authors.forename: S
authors.initials: S
authors.lastname: Hagiwara
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Niikura
authors.forename: H
authors.initials: H
authors.lastname: Terada
authors.forename: S
authors.initials: S
authors.lastname: Tsunawaki
authors.forename: S
authors.initials: S
authors.lastname: Mizutani
authors.forename: T
authors.initials: T
authors.lastname: Kuratsuji
mesh_terms: D000368:Aged; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D006801:Humans; D015467:Leukemia, Neutrophilic, Chronic / Q000235:genetics* / Q000276:immunology; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051562:Proto-Oncogene Proteins c-bcr; D011519:Proto-Oncogenes
chemical_list: D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; C496613:BCR protein, human; D051562:Proto-Oncogene Proteins c-bcr