Protection by recombinant human superoxide dismutase in lethal rat endotoxemia.
In summary as mechanism of the overall protective effect of r-HSOD in lethal rat endotoxemia, inhibition of hemoconcentration, a tendency of a decreased leukocyte activation and attenuation of consumption coagulopathy could be established.
Schneider
J
J
Department of Pharmacology, Grünenthal GmbH, Aachen, FRGermany.
Friderichs
E
E
Giertz
H
H
D000818:Animals; D004731:Endotoxins / Q000097:blood; D004926:Escherichia coli; D005340:Fibrinogen / Q000378:metabolism; D006400:Hematocrit; D006801:Humans; D007958:Leukocyte Count; D010976:Platelet Count; D051381:Rats; D011994:Recombinant Proteins; D018805:Sepsis / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000493:pharmacokinetics / Q000627:therapeutic use*
D004731:Endotoxins; D011994:Recombinant Proteins; D005340:Fibrinogen; D013482:Superoxide Dismutase