Safety of maprotiline in treatment of cardiac patients with left anterior hemiblock.
Based on the reports that maprotiline has a relatively low cardiotoxicity, two depressed patients who had conduction abnormalities of the heart were treated with this medication. In both patients the conduction abnormalities were not affected adversely by maprotiline 100 to 150 mg daily for six weeks. In one patient premature ventricular beats disappeared after maprotiline treatment. In modest dosages, maprotiline seems relatively safe in depressed cardiac patients.
Ghadirian
A M
AM
Ananth
J
J
D000873:Anthracenes / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D004562:Electrocardiography; D005260:Female; D006327:Heart Block / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000627:therapeutic use*; D008875:Middle Aged
D000873:Anthracenes; D008376:Maprotiline