[Inhibitory effect of chemically and enzymatically treated erythrocytic membrane on the invasion of Plasmodium falciparum merozoites].
By treating chemically and enzymatically erythrocytic membrane to change its structure and properties, the recognition of merozoite to erythrocyte and the effect of erythrocyte skeleton protein on the invasion of P. falciparum (Fc c-1/HN) were studied. It was found that the invasion of merozoite into erythrocyte digested with trypsin was greatly decreased; merozoite invasion into the erythrocyte treated with neuraminidase or wheat germ agglutinin (WGA) was partially inhibited; erythrocytes treated with cross-linker diamide and depolymerizer colchicine, N-ethyl maleinimide (NEM) of skeleton protein had evident resistance to invasion; the invasion of merozoite into erythrocyte treated with 2.0 mM of NEM was completely blocked.
Lin
F B
FB
Pan
H Z
HZ
D000818:Animals; D003078:Colchicine / Q000494:pharmacology; D003598:Cytoskeletal Proteins; D003958:Diamide / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000469:parasitology*; D006801:Humans; D008565:Membrane Proteins; D009439:Neuraminidase / Q000494:pharmacology; D009479:Neuropeptides; D010963:Plasmodium falciparum / Q000502:physiology*; D014357:Trypsin / Q000494:pharmacology
D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D009479:Neuropeptides; C028841:erythrocyte membrane band 4.1 protein; C120557:erythrocyte membrane protein band 4.1-like 1; D003958:Diamide; D009439:Neuraminidase; D014357:Trypsin; D003078:Colchicine