title: Ibuprofen in the treatment of acute ankle joint injuries. A double-blind study.
abstract: Sixty-eight patients who presented to the casualty ward with acute ankle joint injuries were studied to examine the effect of ibuprofen on pain and ankle swelling. Thirty-two patients were treated with placebo tablets and 36 with 600 mg ibuprofen tablets taken four times a day for 4 to 6 days. All of the patients were immobilized and requested to keep the foot elevated. The results showed that ibuprofen had no effect on the ankle swelling. The need for additional analgesics was not influenced by treatment with ibuprofen, which means that ibuprofen has no effect on pain. The time elapsed from occurrence of the injury to arrival at the casualty ward was negatively correlated to the reduction of ankle joint swelling during the treatment period. Treatment with ice-sprays, icebags, or cold water during the acute stage of injury did not influence the reduction of swelling during the treatment period.
authors.affiliation: Department of Surgery, Viborg Hospital, Denmark.
authors.forename: U
authors.initials: U
authors.lastname: Fredberg
authors.forename: P A
authors.initials: PA
authors.lastname: Hansen
authors.forename: A
authors.initials: A
authors.lastname: Skinhøj
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D016512:Ankle Injuries; D000843:Ankle Joint / Q000503:physiopathology; D002986:Clinical Trials as Topic; D017679:Cryotherapy; D004311:Double-Blind Method; D004487:Edema / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D011897:Random Allocation
chemical_list: D007052:Ibuprofen