Plant antimutagens, 6. Intricatin and intricatinol, new antimutagenic homoisoflavonoids from Hoffmanosseggia intricata.
Intricatin [1] and intricatinol [2] are new homoisoflavonoids isolated from a desert plant Hoffmanosseggia intricata, which was collected in Baja California, Mexico. The structures of the compounds were elucidated using a variety of spectroscopic techniques. The structure of 1 was shown to be 7,4'-dimethoxy-8-hydroxyhomoisoflavone, and 2 was shown to be 4'-methoxy-7,8-dihydroxyhomoisoflavone. Both compounds 1 and 2 displayed activity in the inhibition of the mutagenicity of 2AN toward Salmonella typhimurium (T98). Compound 2 was much more active than 1 in the case of the inhibition of the mutagenicity of AAF toward S. typhimurium (T98) and the inhibition of EMS towards S. typhimurium (T100). Compounds 1 and 2 are the first examples of antimutagenic activity in homoisoflavones.
Wall
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Research Triangle Institute, North Carolina 27709.
Wani
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MC
Manikumar
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Taylor
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McGivney
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D000818:Animals; D002867:Chromones; D003460:Crystallization; D005419:Flavonoids / Q000302:isolation & purification*; D066298:In Vitro Techniques; D007529:Isoflavones / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009152:Mutagenicity Tests; D009154:Mutation; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics
D002867:Chromones; D005419:Flavonoids; D007529:Isoflavones; C061632:intricatin; C061633:intricatinol