title: H+/K+-adenosine triphosphatase inhibitors. A new approach to the treatment of acid-peptic diseases.
abstract: Due to its potent and long-lasting antisecretory properties is omeprazole, the first clinically used H+/K+-adenosine triphosphatase inhibitor, highly effective in healing of duodenal and gastric ulcers and reflux oesophagitis. Omeprazole is superior to all other presently available antiulcer drugs in the treatment of Zollinger-Ellison syndrome and refractory ulcers. Short-term administration of the drug is safe. However, serum gastrin and gastric enterochromaffin-like cells should be carefully monitored during long-term treatment with the drug.
authors.affiliation: Department of Gastroenterology, University Hospital, Leiden, The Netherlands.
authors.forename: C B
authors.initials: CB
authors.lastname: Lamers
mesh_terms: D004381:Duodenal Ulcer / Q000188:drug therapy*; D004942:Esophagitis, Peptic / Q000188:drug therapy*; D006801:Humans; D009853:Omeprazole / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000188:drug therapy*
chemical_list: D009853:Omeprazole