title: Immunolocalisation of aspartic proteinases in the developing human stomach.
abstract: The distribution and time of appearance in the developing human stomach of the 4 aspartic proteinases, pepsinogen, progastricsin, slow-moving protease and cathepsin D, all present in gastric carcinoma, has been determined by the peroxidase-antiperoxidase method on formalin fixed paraffin embedded sections of fetal stomach. Slow-moving protease appears to be the dominant enzyme from 12 weeks gestation onward, although progastricsin is also present at this time. Pepsinogen and cathepsin D do not appear until 17-18 weeks.
authors.affiliation: Department of Pathology, University of Leeds, UK.
authors.forename: W A
authors.initials: WA
authors.lastname: Reid
authors.forename: K
authors.initials: K
authors.lastname: McGechaen
authors.forename: T
authors.initials: T
authors.lastname: Branch
authors.forename: H D
authors.initials: HD
authors.lastname: Gray
authors.forename: W D
authors.initials: WD
authors.lastname: Thompson
authors.forename: J
authors.initials: J
authors.lastname: Kay
mesh_terms: D016282:Aspartic Acid Endopeptidases; D002402:Cathepsin D / Q000032:analysis; D010450:Endopeptidases / Q000378:metabolism*; D004847:Epithelial Cells; D005753:Gastric Mucosa / Q000166:cytology; D005755:Gastrins / Q000032:analysis; D005865:Gestational Age; D006801:Humans; D007124:Immunoenzyme Techniques; D010435:Pepsinogens / Q000032:analysis; D011498:Protein Precursors / Q000032:analysis; D013270:Stomach / Q000166:cytology / Q000196:embryology*
chemical_list: D005755:Gastrins; D010435:Pepsinogens; D011498:Protein Precursors; C013706:big gastrin; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; D002402:Cathepsin D