[Effect of the immune system functioning of the body on the structure of Salmonella typhimurium populations according to the traits of antibiotic resistance and virulence].
The passage of salmonellae through mice with different immune status (intact, immunosuppressed and immunized) has been found to lead to the multidirectional selection of the animals. Passages through intact and immunosuppressed mice lead mainly to the selection of the animals with the minimal number of resistance markers, while passages through immunized mice result in the selection of the animals with the maximal number of the markers of resistance to antibiotics. The ratio of these kinds of cells coincides with the degree of the virulence of the population: salmonellae isolated from immunosuppressed mice have the highest virulence and those isolated from immunized mice have the lowest virulence.
Kalutskiĭ
P V
PV
Bel'skiĭ
V V
VV
D000818:Animals; D004352:Drug Resistance, Microbial; D005472:Fluorouracil; D007107:Immune System / Q000276:immunology* / Q000382:microbiology; D007114:Immunization; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced / Q000276:immunology / Q000382:microbiology; D051379:Mice; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000382:microbiology; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000276:immunology / Q000472:pathogenicity; D012692:Serial Passage; D014774:Virulence
D005472:Fluorouracil
Vliianie sostoianiia immunnoĭ sistemy organizma na strukturu populiatsiĭ Salmonella typhimurium po priznakam antibiotikorezistentnosti i virulentnosti.