title: Human mast cell proteases and mast cell heterogeneity.
abstract: Mast cell neutral proteases are distinctive markers of the MC(T) and MC(TC) cells in humans. Measurements of tryptase levels in vivo serve as an overall indicator of mast cell activity. Further research is needed to evaluate the functional role of these proteases as well as each mast cell type in situations related to both health and disease.
authors.affiliation: Department of Medicine, Medical College of Virginia, Richmond.
authors.forename: J S
authors.initials: JS
authors.lastname: Miller
authors.forename: L B
authors.initials: LB
authors.lastname: Schwartz
mesh_terms: D015415:Biomarkers; D002268:Carboxypeptidases / Q000378:metabolism; D053818:Chymases; D006801:Humans; D008407:Mast Cells / Q000166:cytology / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000378:metabolism
chemical_list: D015415:Biomarkers; D002268:Carboxypeptidases; D010447:Peptide Hydrolases; C023073:tosylarginine methyl ester hydrolase; D012697:Serine Endopeptidases; D053818:Chymases