Total lymphoid irradiation.
Total lymphoid irradiation (TLI) was shown to have potent immunosuppressive effects in patients with Hodgkin's disease. In the last decade a handful of studies assessed the efficacy of TLI in patients with rheumatoid arthritis. A correlation between decline in T-helper cell number and a reduction in disease activity was noted in all studies; however, the toxicity of TLI remains a major problems limiting a more widespread use of this treatment modality.
Helfgott
S M
SM
Harvard Medical School, Boston, Massachusetts.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000532:radiotherapy*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000532:radiotherapy*; D015182:Lymphatic Irradiation / Q000009:adverse effects