title: [Stereotactically targeted radiotherapy of cerebral arteriovenous malformations].
abstract: A report is given about radiotherapy in 41 patients suffering from cerebral vessel anomalies. A modified linear accelerator was used in a moving field technique with multiple pendulum planes to apply single doses between 8 and 28 Gy by means of stereotaxis into the angiographically determined target volume. The medium follow-up is 23 months. The latency of radiogenic effects is between one and two years. Radiological controls with an interval of more than 18 months after therapy are available in 17 out of 41 patients. Angiographic investigation showed complete obliterations of pathological vessels in six out of these patients and partial obliterations in six patients; five patients remained unchanged. There were no acute complications. Seven patients presented neurological deficiencies with a latency of 6 to 12 months, however, in all cases but one they regressed completely. Even taking into consideration the small number of patients and the short time of observation, a comparison with the results of other radiotherapeutical proceedings allows to draw the conclusion that the presented technique of stereotaxic convergent-beam irradiation represents a relatively simple, reliable and, in case of precise indication, efficient method for the therapy of cerebral arteriovenous malformations.
authors.affiliation: Radiologische Klinik der Universität Heidelberg.
authors.forename: B
authors.initials: B
authors.lastname: Kimmig
authors.forename: R
authors.initials: R
authors.lastname: Engenhart
authors.forename: B
authors.initials: B
authors.lastname: Wowra
authors.forename: K H
authors.initials: KH
authors.lastname: Höver
authors.forename: M
authors.initials: M
authors.lastname: Marin-Grez
authors.forename: V
authors.initials: V
authors.lastname: Sturm
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D010315:Particle Accelerators; D010347:Patient Care Planning / Q000379:methods; D011827:Radiation; D011879:Radiotherapy Dosage; D012074:Remission Induction; D013238:Stereotaxic Techniques; D014057:Tomography, X-Ray Computed
vernacular_title: Stereotaktisch gezielte Strahlentherapie zerebraler arteriovenöser Gefässmissbildungen.