Secretion and membrane assembly.
Cytoplasmic proteins undergo rapid and stable folding which buries their apolar segments. In contrast, precursors of secreted and membrane proteins have apolar segments which are recognized by chaperones and membrane receptors to distinguish them from soluble proteins.
Wickner
W
W
D008565:Membrane Proteins / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*
D008565:Membrane Proteins; D011506:Proteins