title: Hepatic dysfunction in multiple systems organ failure as a manifestation of altered cell-cell interaction.
abstract: Multiple organ failure continues to be the primary cause of death after trauma and sepsis. This clinical syndrome follows shock and resusitation and the transition from a hypermetabolic response to a syndrome of progressive organ failures and death. Risk factors include: perfusion deficits, persistent foci of dead or injured tissue, an uncontrolled focus of infection, the presence of the respiratory distress syndrome, and preexisting fibrotic liver disease. The imitation of the syndrome represents the clinical manifestation of hepatic failure. It is hypothesized that this hepatic failure results from paracrine amplification with Kupffer cell induced hepatocyte cytotoxicity. The best treatment remains prevention and rapid control of risk factors including restoration of oxygen transport and aggressive nutrition support. There seems to be no treatment "magic bullet" either experimentally or clinically once the syndrome has occurred.
authors.affiliation: Department of Surgery, University of Minnesota Medical School, Minneapolis 55455.
authors.forename: F B
authors.initials: FB
authors.lastname: Cerra
authors.forename: M
authors.initials: M
authors.lastname: West
authors.forename: T R
authors.initials: TR
authors.lastname: Billiar
authors.forename: R T
authors.initials: RT
authors.lastname: Holman
authors.forename: R
authors.initials: R
authors.lastname: Simmons
mesh_terms: D000818:Animals; D002450:Cell Communication; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D006801:Humans; D007728:Kupffer Cells / Q000187:drug effects / Q000502:physiology; D008099:Liver / Q000503:physiopathology*; D008262:Macrophage Activation; D009102:Multiple Organ Failure / Q000503:physiopathology*; D018805:Sepsis / Q000150:complications; D014947:Wounds and Injuries / Q000150:complications
chemical_list: D005231:Fatty Acids, Unsaturated