Rodent models of cerebral ischemia.
The use of physiologically regulated, reproducible animal models is crucial to the study of ischemic brain injury--both the mechanisms governing its occurrence and potential therapeutic strategies. Several laboratory rodent species (notably rats and gerbils), which are readily available at relatively low cost, are highly suitable for the investigation of cerebral ischemia and have been widely employed for this purpose. We critically examine and summarize several rodent models of transient global ischemia, resulting in selective neuronal injury within vulnerable brain regions, and focal ischemia, typically giving rise to localized brain infarction. We explore the utility of individual models and emphasize the necessity for meticulous experimental control of those variables that modulate the severity of ischemic brain injury.
Ginsberg
M D
MD
Department of Neurology, University of Miami School of Medicine, FL 33101.
Busto
R
R
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000150:complications; D002545:Brain Ischemia / Q000209:etiology / Q000503:physiopathology; D002536:Cerebral Arteries; D015170:Cerebrospinal Fluid Pressure; D002561:Cerebrovascular Disorders / Q000209:etiology; D004195:Disease Models, Animal; D005849:Gerbillinae; D002534:Hypoxia, Brain / Q000209:etiology; D002542:Intracranial Embolism and Thrombosis / Q000139:chemically induced; D008027:Light; D009462:Neurology / Q000379:methods; D011838:Radiation-Sensitizing Agents; D051381:Rats; D011918:Rats, Inbred SHR
D011838:Radiation-Sensitizing Agents