title: Variable adaptation of molecular mechanisms in relation to the use of autologous striated muscle to augment myocardial function.
abstract: Significant recent advances in molecular biology and protein biochemistry have allowed the examination of muscle function at gene and protein level. This article reviews the variable adaptation of molecular mechanisms in striated muscle. The adaptation and transformation of fast skeletal muscle in response to chronic electrical stimulation may have considerable importance in relation to the use of autologous skeletal muscle to augment myocardial function.
authors.affiliation: Department of Cardiac Surgery, National Heart and Lung Institute, London.
authors.forename: C W
authors.initials: CW
authors.lastname: Pattison
authors.forename: D V
authors.initials: DV
authors.lastname: Cumming
authors.forename: D G
authors.initials: DG
authors.lastname: Clayton Jones
authors.forename: G
authors.initials: G
authors.lastname: Goldspink
authors.forename: M J
authors.initials: MJ
authors.lastname: Dunn
authors.forename: M H
authors.initials: MH
authors.lastname: Yacoub
mesh_terms: D000220:Adaptation, Biological; D004558:Electric Stimulation; D005786:Gene Expression Regulation; D006321:Heart / Q000502:physiology; D006333:Heart Failure / Q000601:surgery*; D006801:Humans; D008954:Models, Biological; D009119:Muscle Contraction; D009124:Muscle Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D009132:Muscles / Q000502:physiology / Q000637:transplantation*; D009200:Myocardial Contraction; D014182:Transplantation, Autologous
chemical_list: D009124:Muscle Proteins