title: Antimicrobial agents in the management of urinary tract infection: an experimental evaluation.
abstract: Persistent and recurrent infections of the urinary tract are a formidable clinical problem, but several recently developed antibiotics have properties that suggest an increased ability to eradicate such infections. Three of the new-generation antibiotics were compared with established agents by using animal models of urinary tract infection. Of the antibiotics tested, gentamicin and ceftriaxone alone were capable of eradicating infection from acute and chronically infected kidney tissue. Chronic lower urinary tract infection was best managed by using norfloxacin or ceftriaxone. Gentamicin, aztreonam, cotrimoxazole and ampicillin were much less effective. In subacute pyelonephritis, gentamicin, aztreonam, norfloxacin and ceftriaxone successfully eliminated microorganisms from most of the infected kidneys, whereas ampicillin and cotrimoxazole had little effect on bacterial numbers. The data have provided an experimental basis for the selection of antibiotics in the management of persistent urinary tract infection.
authors.affiliation: Department of Medicine, Auckland Hospital, New Zealand.
authors.forename: J P
authors.initials: JP
authors.lastname: Lecamwasam
authors.forename: T E
authors.initials: TE
authors.lastname: Miller
mesh_terms: D000208:Acute Disease; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D003556:Cystitis / Q000188:drug therapy* / Q000473:pathology; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D008826:Microbial Sensitivity Tests; D011704:Pyelonephritis / Q000188:drug therapy* / Q000473:pathology; D051381:Rats
chemical_list: D000900:Anti-Bacterial Agents