Therapeutic effect of aspoxicillin on experimental pneumonia with Klebsiella pneumoniae in mice.
The therapeutic effects of aspoxicillin (ASPC) on an experimental pneumonia in mice were compared with those of piperacillin (PIPC) and mezlocillin (MZPC) under various administration schedules. The pneumonia was induced with K. pneumoniae B-54 by the aerosol method. Fifty mg/kg of each penicillin was subcutaneously injected into mice starting from 12 h after infection. At 3- and 6-h interval regimens, ASPC caused the infected mice to survive longer than the other penicillins. The decrease of viable bacterial counts in the lung after a single or repeated injection of ASPC occurred more rapidly than with the other drugs. The concentration of ASPC in the lung after a single injection was higher than that of the other drugs and the concentration was maintained above the MIC for about 2 h. The therapeutic effects of these penicillins on this model reflected well their concentrations in the lung. Among these penicillins, ASPC gave the highest maximum level and persisted longest in the lung, so is shown to have a therapeutic effect superior to PIPC and MZPC on this model of pneumonia. The findings obtained in this experimental pneumonia model were concluded to correlate well with the good clinical efficacy of ASPC compared to PIPC.
Yamaguchi
T
T
Biological Research Laboratory, Tanabe Seiyaku Co. Ltd., Saitama, Japan.
Ishii
N
N
Tani
K
K
Matsushita
T
T
Matsumoto
K
K
D000658:Amoxicillin / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D000818:Animals; D007710:Klebsiella Infections / Q000188:drug therapy* / Q000382:microbiology; D007711:Klebsiella pneumoniae; D008168:Lung / Q000378:metabolism / Q000382:microbiology; D008297:Male; D008802:Mezlocillin / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D010878:Piperacillin / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use
C037485:aspoxicillin; D000658:Amoxicillin; D008802:Mezlocillin; D010878:Piperacillin