Dissolution of bile duct stones.
Mono-octanoin can be used either alone or as an adjunct to other techniques to dissolve cholesterol bile duct stones. This solvent can be administered through an existing T tube, through the nasobiliary route, or percutaneously through the liver. Unlike basket extraction, which requires a mature T-tube sinus tract, mono-octanoin can be used immediately postoperatively or for home dissolution therapy. The endoscopic extraction of bile duct stones has a 1 percent mortality rate and a 5 to 7 percent complication rate. Special mixtures of mono-octanoin, bile acids, and ethylene diaminetetraacetic acid (EDTA) are being evaluated to dissolve pigment stones. The use of methyl tert-butyl ether is still experimental but very effective. To be most successful, mono-octanoin treatment must be used in properly selected patients.
Mack
E
E
Department of Surgery, University of Wisconsin Medical School, Madison.
D001647:Bile Acids and Salts / Q000627:therapeutic use; D001649:Bile Duct Diseases / Q000628:therapy; D002210:Caprylates; D002408:Catheters, Indwelling; D002769:Cholelithiasis / Q000032:analysis / Q000628:therapy*; D004987:Ethers / Q000627:therapeutic use; D005989:Glycerides / Q000627:therapeutic use; D006801:Humans; D012997:Solvents / Q000627:therapeutic use*
D001647:Bile Acids and Salts; D002210:Caprylates; D004987:Ethers; D005989:Glycerides; D012997:Solvents; C025343:monooctanoin