[Evaluation of the treatment of ovarian infertility in women with moderate hyperprolactinemia].
The authors evaluated the therapy by means of clomiphene++ and hCG in a group of 34 menstruating women aged 18-41 who suffered from ovarian infertility and hyperprolactinaemia not exceeding 100 ng/ml. Previous treatment of the women by means of bromoergocryptine decreasing the prolactin concentration did not provoked ovulation. It was found that moderate hyperprolactinaemia still blocked ovulation in one third of the women undergoing therapy. In a group of patients with a concentration of PRL from 50 to 100 ng/ml of blood serum there was a lower percentage of ovulation (62% v 67%) and subsequent pregnancies (23% v 33%). The authors did not find hypofunction of corpus luteum in women who reacted to the therapy. The average progesterone concentration amounted to 11.2 +/- 2.6 ng/ml of blood serum. The hormone concentration was significantly lower in a group of women with prolactinaemia exceeding 50 ng/ml (10.4 +/- 2.5 ng/ml vs 12.6 +/- 3.1 t = 1.86, p less than 0.1). The course of subsequent pregnancies in all cases, also in the group of women with prolactinaemia exceeding 50 ng/ml, was favourable.
Jakowicki
J
J
Postawski
K
K
Kozdra-Kucharczyk
B
B
D000293:Adolescent; D000328:Adult; D000858:Anovulation / Q000150:complications / Q000188:drug therapy*; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D002996:Clomiphene / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006728:Hormones / Q000008:administration & dosage; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications*; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D010062:Ovulation Induction
D006063:Chorionic Gonadotropin; D006728:Hormones; D002996:Clomiphene
Ocena leczenia niepłodności jajnikowej u kobiet z mierna hyperprolaktynemia.