[Long-term therapy with nitrates. How can continuous effectiveness be achieved?].
Due to rapidly occurring tolerance, "continuous" administration of nitrates can no longer be considered justified. The development of tolerance can be avoided and, thus, the antiischemic effect maintained during long-term treatment only by providing a nitrate-free interval. Dosing regimens with documented effectiveness in long-term controlled studies are available for both isosorbide dinitrate and isosorbide 5-mononitrate as well as for transdermal nitroglycerin systems.
Rudolph
W
W
Dirschinger
J
J
Reiniger
G
G
Beyerle
A
A
D000279:Administration, Cutaneous; D000787:Angina Pectoris / Q000188:drug therapy*; D003327:Coronary Disease / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives; D009566:Nitrates / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D009566:Nitrates; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate
Langzeittherapie mit Nitraten. Wie ist eine anhaltende Effektivität zu gewährleisten?