title: Contributions of experimental tumors to the relationship between carcinogenesis and differentiation.
abstract: Brain tumors are experimentally inducible in adult and newborn animals and in the offspring by transplacental administration of brain-specific carcinogens, such as Methylnitrosourea (MNU) and Ethylnitrosourea (ENU). These compounds are quite reliable in producing tumors in the offspring with a well-defined pattern. These NU-induced tumors can be considered an important model-system mainly for the investigation of the early stages in the tumorigenesis of endocranic neoplasias.
authors.affiliation: Clinica Neurologica II, Università di Torino, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Schiffer
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development; D001932:Brain Neoplasms / Q000139:chemically induced / Q000473:pathology*; D002454:Cell Differentiation; D005038:Ethylnitrosourea; D008770:Methylnitrosourea; D051381:Rats
chemical_list: D008770:Methylnitrosourea; D005038:Ethylnitrosourea