Comparison of one dose cefazolin versus one dose cefotetan for cesarean section prophylaxis.
During one year, 646 women who delivered by cesarean section entered into a prospective randomized clinical trial to determine if a single intraoperative dose of cefazolin was as effective as cefotetan in the prevention of postoperative endomyometritis. Of 336 patients receiving 2 gm cefazolin intravenously at the time of clamping of the cord, endomyometritis developed in 30 (8.91%), and of 310 patients who received 2 gm cefotetan intravenously at the time of clamping of the cord, endomyometritis developed in 36 (11.6%). There was no statistically significant difference in the incidence of endomyometritis between the two groups (p = .269). We conclude that since the two drugs are equal in efficacy 2 gm of cefazolin is a cost effective method of prophylaxis for cesarean section.
Probst
J R
JR
Benrubi
G I
GI
Sanchez-Ramos
L
L
Todd
M
M
D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000517:prevention & control*; D002437:Cefazolin / Q000008:administration & dosage / Q000627:therapeutic use*; D015313:Cefotetan / Q000008:administration & dosage / Q000627:therapeutic use*; D002585:Cesarean Section / Q000009:adverse effects*; D004716:Endometritis / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic
D015313:Cefotetan; D002437:Cefazolin