title: Decreased essential antioxidants and increased lipid hydroperoxides following high-dose radiochemotherapy.
abstract: The blood from 19 patients having bone marrow transplantation was examined for the essential antioxidants alpha-tocopherol and beta-carotene as well as lipid hydroperoxides before, at and after bone marrow transplantation (BMT). Conditioning therapy, preceding BMT in order to achieve marrow ablation and immunosuppression, consists of high-dose chemotherapy which is mostly combined with total body irradiation (TBI). In order to see a possible difference between patients with and without additional TBI, we divided the patients up into two groups; patients receiving TBI (RT+) and patients without TBI (RT-). All patients required total parenteral nutrition beginning one week prior to BMT. After conditioning therapy plasma levels of absolute and lipid-standardized alpha-tocopherol and beta-carotene decreased in both groups, presumably as a result of an enhanced breakdown of these antioxidants. The loss of these lipid-soluble antioxidants has to be considered as a possible cause for early post-transplant toxicity. Lipid hydroperoxides increase significantly in the group of patients with additional TBI, whereas the other group, receiving no additional TBI, showed no significant change. We suggest high-dose supplementation of essential antioxidants for patients undergoing BMT.
authors.affiliation: Eberhard-Karls-Universität Tübingen, Federal Republic of Germany.
authors.forename: M R
authors.initials: MR
authors.lastname: Clemens
authors.forename: C
authors.initials: C
authors.lastname: Ladner
authors.forename: H
authors.initials: H
authors.lastname: Schmidt
authors.forename: G
authors.initials: G
authors.lastname: Ehninger
authors.forename: H
authors.initials: H
authors.lastname: Einsele
authors.forename: E
authors.initials: E
authors.lastname: Bühler
authors.forename: H D
authors.initials: HD
authors.lastname: Waller
authors.forename: K F
authors.initials: KF
authors.lastname: Gey
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002338:Carotenoids / Q000097:blood*; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D014810:Vitamin E / Q000097:blood*; D014916:Whole-Body Irradiation; D019207:beta Carotene
chemical_list: D000970:Antineoplastic Agents; D008054:Lipid Peroxides; D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids