Aztreonam in the management of gram-negative infections in penicillin-allergic patients: a review.
Penicillins and cephalosporins, which are well-tolerated by most patients, can result in hypersensitivity reactions. This factor not only limits the use of beta-lactam antibiotics but also presents challenges to the selection of alternative drugs because of the potential for cross-reactivity. Evidence suggests that aztreonam, the prototype of the new monobactam class of beta-lactam antibiotics, may be a safe alternative antibiotic for managing Gram-negative infections in penicillin-allergic patients.
Saxon
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Department of Medicine, UCLA School of Medicine 90024.
D001398:Aztreonam / Q000276:immunology / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D002511:Cephalosporins / Q000009:adverse effects*; D003429:Cross Reactions; D004342:Drug Hypersensitivity / Q000276:immunology; D006090:Gram-Negative Bacteria; D006801:Humans; D015394:Molecular Structure; D010406:Penicillins / Q000009:adverse effects* / Q000276:immunology
D002511:Cephalosporins; D010406:Penicillins; D001398:Aztreonam