Localization of hepatitis B virus in a primary testicular cancer.
An embryonal carcinoma of the testicle developed in a 29-year-old white man 3 months after recovery from hepatitis B surface antigen-positive hepatitis. Microscopic sections prepared with formalin-fixed tumor tissue were stained with anti-hepatitis B surface antibody and examined by fluorescent microscopy. Appropriate control procedures, including absorption techniques, were also performed. The carcinoma cells contained hepatitis B surface antigen; controls, including sections from normal testicles and three other testicular tumors, were negative. The result indicates that the hepatitis B virus in this case was localized in the tumor cells. The patient was alive and well 4 years after undergoing orchiectomy and chemotherapy.
Somlo
F
F
Department of Laboratories, St Mary's Hospital Center, Montreal, Canada.
D000328:Adult; D005455:Fluorescent Antibody Technique; D006509:Hepatitis B / Q000150:complications; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D013724:Teratoma / Q000150:complications / Q000382:microbiology*; D013736:Testicular Neoplasms / Q000150:complications / Q000382:microbiology*
D006514:Hepatitis B Surface Antigens