Lateralization of neocortical dopamine receptors and dopamine level in normal Wistar rats.
A lateral asymmetry of dopamine receptors (D-1, D-2) and dopamine (DA) level was found in the left and right neocortices of male Wistar rats. The specific D-1 receptor binding (3H-SCH 23390) was by 24% (p less than 0.05), the specific D-2 receptor binding (3H-spiperone)----by 31% (0.1 greater than p greater than 0.05) and the DA level ---- by 80% higher (p less than 0.001) in the right than in the left neocortex. In the other examined brain regions (striatum and limbic system) no lateralization in D-1 or D-2 receptors was observed. The physiological significance of the neocortical lateralization (DA receptors and level) is unknown, yet it is important for experimental and methodological reasons.
Nowak
G
G
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
D000818:Animals; D001552:Benzazepines / Q000378:metabolism; D001667:Binding, Competitive / Q000187:drug effects; D002540:Cerebral Cortex / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D008032:Limbic System / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism
D001552:Benzazepines; D011954:Receptors, Dopamine; D013134:Spiperone; D004298:Dopamine