Anti-secretagogue effect of lithium on isolated rat islets of Langerhans.
Administration of lithium carbonate solution (50 mg/kg, po, twice daily) to Charles Foster male albino rats for 45 consecutive days caused an intolerance to oral glucose. Inhibition in (pro)insulin biosynthesis followed by a significant fall in immunoreactive insulin release was seen in islets isolated from identically treated rats. As the activities of acid phosphatase and cathepsin B were unaltered, it is possible that the anti-secretagogue effect is sequential to inhibition of (pro)insulin biosynthesis by lithium.
Chandrasekar
B
B
Mathur
S K
SK
Mukherjee
S K
SK
D000818:Animals; D007328:Insulin / Q000096:biosynthesis / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D051381:Rats
D007328:Insulin; D008094:Lithium