title: [The climacteric--physiology or pathology?].
abstract: Nearly 30 years of a woman's life is spent after cessation of the reproductive function and about 30% of the female population in Europe is postmenopausal. The medical infirmities resulting from estrogen deprivation among postmenopausal women take a high toll. The greatest number of hip fractures because of osteoporosis occur in this group, resulting in a high death (20%-30%) and morbidity rate. Estrogen deprivation leads to a change of the lipid metabolism with acceleration of arteriosclerosis. While the "estrogen forever" era closed with a striking rise in the incidence of adenocarcinoma of the endometrium, combined estrogen-gestagen treatment drastically decreases the incidence of endometrial and breast carcinoma. Therefore, physicians must be aware of the benefits of estrogen-gestagen treatment and act appropriately.
authors.affiliation: Universitäts-Frauenklinik Düsseldorf.
authors.forename: W
authors.initials: W
authors.lastname: Distler
mesh_terms: D002979:Climacteric / Q000187:drug effects*; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control; D012307:Risk Factors
chemical_list: D004967:Estrogens; D008055:Lipids
vernacular_title: Klimakterium--Physiologie oder Pathologie?