title: Stereotactic heavy-charged-particle Bragg peak radiosurgery for the treatment of intracranial arteriovenous malformations in childhood and adolescence.
abstract: Forty patients aged 6 to 18 years have now been treated for inoperable intracranial arteriovenous malformations (AVMs) using stereotactic heavy-charged-particle Bragg peak radiosurgery at the Lawrence Berkeley Laboratory 184-inch Synchrocyclotron at the University of California, Berkeley. This paper describes the procedures for selection of patients, the treatment protocol, and the neurological and neuroradiological responses to stereotactic radiosurgery in this age group. The volumes of the treated AVMs ranged from 265 mm3 to 60,000 mm3. The results are favorable: thus far, 20 of 25 patients have experienced greater than or equal to 50% obliteration of their AVMs within 1 year after treatment, and 14 of 18 patients have experienced total obliteration of the AVM by 2 years after treatment. Two patients hemorrhaged from radiosurgically treated AVMs within 12 months after treatment, but none thereafter. Complications include vasogenic edema and arterial occlusion; three patients have had neurological worsening as definite or possible sequelae of treatment. The strengths and limitations of the method are discussed.
authors.affiliation: Donner Pavilion and Donner Laboratory, Lawrence Berkeley Laboratory, University of California, Berkeley.
authors.forename: R P
authors.initials: RP
authors.lastname: Levy
authors.forename: J I
authors.initials: JI
authors.lastname: Fabrikant
authors.forename: K A
authors.initials: KA
authors.lastname: Frankel
authors.forename: M H
authors.initials: MH
authors.lastname: Phillips
authors.forename: J T
authors.initials: JT
authors.lastname: Lyman
mesh_terms: D000293:Adolescent; D002543:Cerebral Hemorrhage / Q000532:radiotherapy; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006371:Helium / Q000627:therapeutic use; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation; D008297:Male; D011446:Prospective Studies; D011868:Radioisotopes / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation; D013238:Stereotaxic Techniques / Q000295:instrumentation*
chemical_list: D011868:Radioisotopes; D006371:Helium