Perinephritis hypertension in Macaca fascicularis (cynomolgus monkey): studies of the renin-angiotensin-aldosterone axis and renal hemodynamic function.
The purpose of the present study was to characterize the etiology of bilateral perinephritis hypertension in the non-human primate. Hypertension was induced in female cynomolgus (Macaca fascicularis) monkeys by wrapping both kidneys under sterile surgical procedures. Mean arterial pressure (MAP), plasma renin activity (PRA), plasma aldosterone concentration (ALDO), para-aminohippurate (PAH) clearance, glomerular filtration rate (GFR), urine volume, and sodium and potassium excretion were measured before and weekly after induction of the hypertension. MAP increased progressively from 108 +/- 1 to 135 +/- 4 mmHg during the first 6 weeks; thereafter, MAP remained at this elevated level, PRA was elevated two- to fivefold for up to 10 weeks after the hypertension and ALDO was elevated during 1 (139%), 4 (60%), 6 (196%), 8 (249%) and 10 (148%) weeks of the hypertension. PAH clearance and GFR were significantly reduced during week 1 of the hypertension, but returned to control values by week 2. Urine volume was increased significantly during the first week of the hypertension, while sodium and potassium excretion were not changed. Captopril (15 mumol/kg, intravenously) normalized the blood pressure regardless of the severity or duration of the disease. Additionally, captopril lowered ALDO and increased PRA. It is concluded that bilateral perinephritis hypertension in the monkey is dependent on increased activity of the renin-angiotensin-aldosterone axis.
DeForrest
J M
JM
Department of Pharmacology, Squibb Institute for Medical Research, Princeton, NJ 08543-4000.
Scalese
R J
RJ
Oehl
R S
RS
Waldron
T L
TL
Mitch
S
S
Brittain
R J
RJ
Free
C A
CA
Asaad
M
M
Burkett
D
D
D000818:Animals; D002216:Captopril / Q000494:pharmacology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006977:Hypertension, Renal / Q000209:etiology* / Q000378:metabolism; D007677:Kidney Function Tests; D008252:Macaca fascicularis; D010501:Perinephritis / Q000150:complications* / Q000378:metabolism; D012084:Renin-Angiotensin System
D002216:Captopril