Clinical evaluation of W14859 (liquid thrombin) on upper gastro-intestinal haemorrhage--comparative study of W14859 versus topical thrombin.
W14859 (liquid thrombin) was used to treat upper gastro-intestinal haemorrhage confirmed by endoscopy. Haemostatic effects were compared with those of topical thrombin. W14859 was administered directly under endoscopy and/or orally in 29 patients with upper gastro-intestinal haemorrhage. Haemostasis was achieved using direct application and subsequent oral thrombin in 17/19 (89.5%) cases, and direct or oral treatment alone in 4/6 (66.7%) cases. The efficacy rate was higher in non-transfused patients. In all 25 stomach biopsy patients, haemostasis was achieved within 60 s of directly applying W14859. There was no significant difference between the mean time taken by W14859 (17.7 +/- 2.1 s) and topical thrombin (14.6 +/- 2.0 s) and no adverse events were observed in any of the patients. It is, therefore, believed that W14859 can be routinely used in clinical practice.
Nakajima
T
T
Keiseikai Hospital, Higashi-Osaka City, Japan.
Himeno
S
S
D000287:Administration, Topical; D002986:Clinical Trials as Topic; D004304:Dosage Forms; D004381:Duodenal Ulcer / Q000628:therapy; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D008297:Male; D012996:Solutions; D013276:Stomach Ulcer / Q000628:therapy; D013917:Thrombin / Q000008:administration & dosage / Q000627:therapeutic use*
D004304:Dosage Forms; D012996:Solutions; D013917:Thrombin