Interaction of meropenem with humoral and phagocytic defences.
Meropenem and imipenem were compared for their capacity to kill intracellular Staphylococcus aureus, to alter the pattern of lysis of serum-sensitive or resistant Escherichia coli, and to affect the uptake and intracellular killing of opsonized S. aureus by human neutrophils and mouse peritoneal macrophages. Meropenem killed intracellular S. aureus at concentrations equal to eight times the MBC while imipenem did not. Neither antibiotic had any significant effect on any of the other interactions studied.
Easmon
C S
CS
Department of Medical Microbiology, Wright-Fleming Institute, St. Mary's Hospital Medical School, London, UK.
D000917:Antibody Formation / Q000187:drug effects*; D015780:Carbapenems / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D015378:Imipenem / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D009504:Neutrophils / Q000187:drug effects; D009895:Opsonin Proteins / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects; D013845:Thienamycins / Q000494:pharmacology*
D015780:Carbapenems; D009895:Opsonin Proteins; D013845:Thienamycins; D015378:Imipenem; D000077731:Meropenem