title: [Open clinical study of liposomal superoxide dismutase in severe rheumatoid arthritis. Study of a series of 7 cases].
abstract: An open clinical study of treatment of severe rheumatoid arthritis (7 cases) with liposomal bovine copper superoxide dismutase is described. The drug was administered by intramuscular injection twice a week for three months and was well tolerated. Of the seven cases five showed good or very good results with significant amelioration. The absence of toxicity indicates that liposomal superoxide dismutase may be used in future trials with a greater number of patients.
authors.forename: P
authors.initials: P
authors.lastname: Richard
authors.forename: H
authors.initials: H
authors.lastname: Roux
authors.forename: J P
authors.initials: JP
authors.lastname: Mattei
authors.forename: A M
authors.initials: AM
authors.lastname: Michelson
authors.forename: G
authors.initials: G
authors.lastname: Jadot
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D008081:Liposomes; D013482:Superoxide Dismutase
vernacular_title: Etude clinique ouverte de la superoxyde dismutase liposomale dans la polyarthrite rhumatoïde sévère. Etude d'une série de 7 cas.