Self non self discrimination within the immune system: a view from the bridge.
The author reviews the actual concepts on the mechanisms of self-tolerance. He underlines the complexity and the complementarity of the different phenomenons of clonal deletion, clonal anergy and suppression. In addition, he proposes a new theory on the generation of the immune repertoires based on the presentation of self-antigens by particular antigen-presenting cells, the self-presenting cells.
Urbain
J
J
Département de Biologie Moléculaire, Université Libre de Bruxelles, Rhode Saint Genèse.
Urbain-Vansanten
G
G
De Wit
D
D
D001324:Autoantigens / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D001324:Autoantigens