[Pancreatoduodenal transplantation with and without the spleen in an animal experiment].
It is a report on the heterotop transplantation of the pancreas with duodenum with or without spleen to diabetic mini-pigs. 7 days after a total resection of the pancreas the truncus coeliacus of the transplant is anastomosed end-to-side with the distal aorta. The same is done with the vena cava inferior. After having closed the duodenum orally the pancreatic juice is drained through on anus praeter. The immunosuppression is reached by giving Cyclosporin A and prednisolone after having analyzed the blood picture. The postoperative laboratory tests as well as affection tests including selective angiographic and nuclear medical in vivo controls show the efficiency of this transplantation variant to control a diabetic metabolic level for several weeks without an external insulin supply. The transplantation model described is technically uncomplicated and it is the basis for further studies.
Friess
P
P
Klinik für Chirurgie, Bereiches Medizin (Charité) der Humboldt-Universität zu Berlin.
Lippert
H
H
D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002445:Celiac Artery / Q000601:surgery; D003524:Cyclosporins / Q000008:administration & dosage; D003921:Diabetes Mellitus, Experimental / Q000601:surgery*; D004386:Duodenum / Q000637:transplantation*; D005260:Female; D008297:Male; D010179:Pancreas / Q000098:blood supply; D016035:Pancreas Transplantation; D010180:Pancreatectomy; D011169:Portal Vein / Q000601:surgery; D011183:Postoperative Complications / Q000175:diagnosis; D013154:Spleen / Q000637:transplantation*; D013536:Suture Techniques; D013552:Swine; D013556:Swine, Miniature; D013927:Thrombosis / Q000175:diagnosis; D014682:Vena Cava, Inferior / Q000601:surgery
D001786:Blood Glucose; D003524:Cyclosporins
Pankreatoduodenale Transplantation mit und ohne Milz im Tierexperiment.