Immune hemolysis after an ABO mismatched renal transplant.
We describe a case of immune hemolysis due to anti-B occurring in a blood group B patient 16 days after a cadaveric renal transplantation from a blood group O donor. Transfusional support was initially required and the direct antiglobulin test (DAT) remained positive for 80 days. Cyclosporin A (CSA), which was used for rejection prophylaxis in this case, has unique immunosuppressive capabilities which protects transplanted organs from rejection, but which might permit this type of 'graft versus host' reaction.
Perkins
A C
AC
Haematology Department, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
Richards
V L
VL
Gibson
J
J
Joshua
D E
DE
Johnson
J R
JR
Kronenberg
H
H
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D003524:Cyclosporins / Q000009:adverse effects / Q000276:immunology; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D016030:Kidney Transplantation; D008297:Male
D000017:ABO Blood-Group System; D001323:Autoantibodies; D003524:Cyclosporins