[Macrophages in central nervous canine distemper: friends or foes?].
Brain macrophages play an important role in the CNS. We review some biological aspects of brain macrophages in vivo and in vitro. The criteria and methods used for the identification of these cells are considered. They include some morphological features such as the use of histochemical and immunocytochemical techniques for internal and surface components. In the second part of this review, we describe the role of brain macrophages in canine distemper encephalitis as proposed earlier by us. Studies in cultured dog glial cells infected with canine distemper virus (CDV) have shown that brain macrophages stimulated by anti-CDV antibodies will release reactive oxygen species as measured by chemiluminescence. This response depends on the presence of viral antigens on the surfaces of infected cells and is mediated by the interaction of antigen-bound antibodies with Fc receptors on brain macrophages. These observations support the hypotheses that brain macrophages may contribute to the damage of the white matter observed in canine distemper encephalitis.
Griot
C
C
Bürge
T
T
Brigger
S
S
Richard
A
A
Peterhans
E
E
Vandevelde
M
M
D000818:Animals; D001921:Brain / Q000473:pathology*; D004216:Distemper / Q000473:pathology*; D004285:Dogs; D008264:Macrophages / Q000502:physiology*
Makrophagen bei der zentralnervösen Hundestaupe: Freunde oder Feinde?