[Cimetidine treatment of stomach cancer].
The effect of cimetidine treatment in cancer of the stomach was investigated in a double-blind, multicentre study comprising eight departments in Greater Copenhagen. Immediately after operation (or the decision not to operate) 181 patients were subdivided at random to treatment with a placebo or cimetidine in a dosage of 400 mg twice daily for two years or until death. Compliance control was carried out every third month. The mean survival in the cimetidine group (450 days, 1-1,826) was significantly longer (p = 0.02) than in the placebo group (316 days, 1-1,653).
Tønnesen
H
H
Knigge
U P
UP
Bülow
S
S
Damm
P
P
Fischerman
K
K
Hesselfeldt
P
P
Hjortrup
A
A
Pedersen
I K
IK
Pedersen
V M
VM
Siemssen
O J
OJ
D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality
D002927:Cimetidine
Cimetidinbehandling ved cancer ventriculi.