Relapsing poly(peri)chondritis associated with fibrosing alveolar disease and antibodies to pneumocytes type II and Clara cells.
A 62-year-old man with histological confirmed relapsing polychondritis showed chondritis of ears and nose, arthritis, keratitis and a hemolytic anemia. The bronchoalveolar lavage, computed tomography of the thorax and pulmonary function tests disclosed findings compatible with fibrosing alveolar disease. IgG antibodies to alveolar pneumocytes type II and bronchiolar Clara cells were detected by indirect immunofluorescence of human lung tissue. To our knowledge this is the first report of fibrosing alveolar disease in relapsing polychondritis and detection of antibodies to human pneumocytes type II and Clara cells.
Rauh
G
G
Medizinische Poliklinik der Universität München.
Dörfler
H
H
Erlinger
R
R
Riedel
K G
KG
Zöllner
N
N
D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology; D001980:Bronchi / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010007:Osteochondritis / Q000175:diagnosis*; D011650:Pulmonary Alveoli / Q000276:immunology*; D011658:Pulmonary Fibrosis / Q000175:diagnosis* / Q000276:immunology
D001323:Autoantibodies; D007074:Immunoglobulin G