Plasmodium falciparum: inhibitor sensitivity of the endogenous superoxide dismutase.
Plasmodium falciparum, unlike P. berghei, contains two superoxide dismutases (SOD). We have previously found that the major isozyme is cyanide sensitive and appears, like the P. berghei SOD, to be adopted from its host, whereas the minor isozyme was found to be cyanide insensitive. We now report that the minor parasite-associated enzyme is peroxide insensitive, suggesting that it is manganese containing.
Ranz
A
A
Department of Microbiology, City University of New York Medical School, City College, New York 10031.
Meshnick
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SR
D000818:Animals; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007527:Isoenzymes / Q000032:analysis*; D008345:Manganese / Q000032:analysis; D010963:Plasmodium falciparum / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000032:analysis* / Q000037:antagonists & inhibitors
D007527:Isoenzymes; D008345:Manganese; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase