title: The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial.
abstract: We evaluated an anti-inflammatory enzyme drug Danzen (Serrapeptase: Takeda Chemical Industries, Ltd.) on 70 patients complaining of breast engorgement. These patients were randomly divided into 2 groups, a treatment group and a placebo group. A single observer, unaware of the group the patients were in, assessed the severity of each of the symptoms and signs of breast engorgement before treatment was commenced, and daily for 3 days, during which therapy was administered. Danzen was noted to be superior to placebo for improvement of breast pain, breast swelling and induration and while 85.7% of the patients receiving Danzen had "Moderate to Marked" improvement, only 60.0% of the patients receiving placebo had a similar degree of improvement. "Marked" improvement was found in 22.9% of the treatment group and 2.9% of the placebo group. These differences were statistically significant (P less than 0.05). No adverse reactions were reported with the use of Danzen. Danzen is a safe and effective method for the treatment of breast engorgement.
authors.forename: W H
authors.initials: WH
authors.lastname: Kee
authors.forename: S L
authors.initials: SL
authors.lastname: Tan
authors.forename: V
authors.initials: V
authors.lastname: Lee
authors.forename: Y M
authors.initials: YM
authors.lastname: Salmon
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001942:Breast Feeding; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007774:Lactation / Q000187:drug effects*; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D011247:Pregnancy; D011644:Puerperal Disorders / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010447:Peptide Hydrolases; C022640:serratiopeptidase