title: [Effect and tolerance of ofloxacin in bronchopulmonary infections in comparison with amoxicillin].
abstract: Ofloxacin and amoxicillin in the treatment of 121 bronchopulmonary infections were compared in a randomized, open clinical trial. 64% of the infections were pneumonias. S. pneumoniae, H. influenzae and B. catarrhalis accounted for 76% of the etiologic agents. The clinical and bacteriological responses were positive in more than 90% of the patients and comparable in both groups. None of the isolated agents was resistant to ofloxacin, whereas 21% were amoxicillin-resistant. Ofloxacin was used without randomization in the treatment of 26 atypical pneumonias and opportunistic infections, all of which were cured or improved. Occurrence of side-effects was rarely observed in either treatment group.
authors.affiliation: Service de médecine interne, Hôpital cantonal, Fribourg.
authors.forename: C
authors.initials: C
authors.lastname: Chuard
authors.forename: C
authors.initials: C
authors.lastname: Regamey
mesh_terms: D000368:Aged; D000658:Amoxicillin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D015242:Ofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D011014:Pneumonia / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic; D012141:Respiratory Tract Infections / Q000188:drug therapy*
chemical_list: D000658:Amoxicillin; D015242:Ofloxacin
vernacular_title: Wirksamkeit und Verträglichkeit von Ofloxacin bei bronchopulmonalen Infektionen im Vergleich zu Amoxicillin.