Detection of measles virus genome in blood leucocytes of patients with certain autoimmune diseases.
RNA isolated from lymphocytes of peripheral blood was dot-hybridized to a hybrid plasmid containing specific sequences for measles virus nucleocapsid protein. Viral RNA was detected in the lymphocytes of 28 of 34 (82%) patients with systemic lupus erythematosus (SLE) and of 40 of 68 (59%) patients with chronic glomerulonephritis (CGN), and was not detected in 29 control patients.
Andjaparidze
O G
OG
Moscow Research Institute for Viral Preparations, Academy of Medical Sciences, U.S.S.R.
Chaplygina
N M
NM
Bogomolova
N N
NN
Koptyaeva
I B
IB
Nevryaeva
E G
EG
Filimonova
R G
RG
Tareeva
I E
IE
D000911:Antibodies, Monoclonal / Q000276:immunology; D002213:Capsid / Q000235:genetics / Q000276:immunology; D015342:DNA Probes; D005455:Fluorescent Antibody Technique; D005814:Genes, Viral; D005921:Glomerulonephritis / Q000382:microbiology*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D008177:Lupus Vulgaris / Q000382:microbiology*; D008214:Lymphocytes / Q000382:microbiology*; D008459:Measles virus / Q000235:genetics* / Q000302:isolation & purification; D012367:RNA, Viral / Q000032:analysis*; D014758:Viral Core Proteins / Q000235:genetics / Q000276:immunology
D000911:Antibodies, Monoclonal; D015342:DNA Probes; D012367:RNA, Viral; D014758:Viral Core Proteins