Response to alternative antidepressants in imipramine nonresponders with bulimia nervosa.
The authors report the results of open-label antidepressant trials in a series of normal weight bulimic women who showed an inadequate response to an initial trial of imipramine hydrochloride as part of a treatment comparison study. The results indicate that a significant percentage of subjects responded to a second trial of an alternative agent. Overall, 47% had a complete remission of symptoms during the second trial, usually with a monoamine oxidase inhibitor or fluoxetine. The authors stress the importance of persisting in trials of alternative agents if bulimic patients fail to respond to an initial trial.
Mitchell
J E
JE
Department of Psychiatry, University of Minnesota Hospital, Minneapolis.
Pyle
R L
RL
Eckert
E D
ED
Hatsukami
D
D
Pomeroy
C
C
Zimmerman
R
R
D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002032:Bulimia / Q000188:drug therapy* / Q000523:psychology; D002986:Clinical Trials as Topic; D003891:Desipramine / Q000627:therapeutic use; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use; D009661:Nortriptyline / Q000627:therapeutic use; D011897:Random Allocation
D000928:Antidepressive Agents; D008996:Monoamine Oxidase Inhibitors; D005473:Fluoxetine; D009661:Nortriptyline; D007099:Imipramine; D003891:Desipramine