Vitamin E and cardiovascular disease.
Randomized clinical trials of the effects of Vitamin E on complaints of intermittent claudication and angina pectoris are reviewed, and their methodological shortcomings are considered. Mechanisms by which Vitamin E might act in cardiovascular disease are discussed. The evidence about the possible pharmacological actions of Vitamin E supports the need for randomized clinical trials. It is concluded that Vitamin E may have a positive effect, especially in intermittent claudication.
Kleijnen
J
J
Department of Epidemiology/Health Care Research, University of Limburg, Maastricht, The Netherlands.
Knipschild
P
P
ter Riet
G
G
D000787:Angina Pectoris / Q000188:drug therapy*; D015982:Bias; D004311:Double-Blind Method; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D006801:Humans; D007383:Intermittent Claudication / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use*
D005231:Fatty Acids, Unsaturated; D014810:Vitamin E