title: Splenopentin--influence on antibody formation in immunosuppressed animals and on phagocytic capability of human granulocytes.
abstract: Sublethally x-ray irradiated C57 Bl/6 Bln. mice (whole body irradiation with 600 cGy) were treated with or without a splenopentin derivative (DA SP-5: N alpha-acetyl-L-arginyl)-(N alpha-acetyl-L-lysyl)-L-glutamyl-L-valyl-L-tyrosine and compared for their capacity to produce antibodies against target sheep red blood cells. As demonstrated DA SP-5 treated mice produced antibodies earlier and in a higher level than animals untreated. Furthermore, DA SP-5 influences the phagocytic capability of human granulocytes in a dose dependent matter.
authors.affiliation: Department of Dermatology, Medical School (Charité), Humboldt University, Berlin.
authors.forename: W
authors.initials: W
authors.lastname: Diezel
authors.forename: R
authors.initials: R
authors.lastname: Eckert
authors.forename: G M
authors.initials: GM
authors.lastname: Müller
authors.forename: K
authors.initials: K
authors.lastname: Forner
authors.forename: N
authors.initials: N
authors.lastname: Sönnichsen
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D007109:Immunity / Q000187:drug effects / Q000528:radiation effects*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*; D013946:Thymopoietins / Q000138:chemical synthesis / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*; D014916:Whole-Body Irradiation
chemical_list: D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; C060485:berlopentin