[Study of the relation of various genetic and pathophysiologic factors participating in the regulation of blood pressure in patients with hypertension].
A study of 35 patients with uncomplicated essential hypertension (EH) (labile hypertension, stages IB-IIA or stable hypertension, stage IIB) demonstrated a higher rate of Na+-Li+ countertransport in patients with hypertensive hereditary predisposition to EH (group 1), as compared to those with unaggravated heredity (group 2). A suppression of plasma renin activity (53%), and a higher rate of hyperlipoproteinemia (55%) were observed in group 1, as opposed to group 2 where Na+-Li+ countertransport was lower, plasma renin activity was normal, and hyperlipoproteinemia occurred in 33%. There was a direct correlation between Na+-Li+ countertransport and renin-angiotensin-aldosterone components in group 2. A conclusion is made that aggravated heredity, RAAS components and hyperlipoproteinemia should be taken into account in the assessment of Na+-Li+ countertransport in hypertensive patients.
Shkhvatsabaia
I K
IK
Zharova
E A
EA
Vil'chinskaia
M Iu
MIu
Kaĭkov
M I
MI
Petrov
V V
VV
D000328:Adult; D017920:Antiporters; D001692:Biological Transport; D001794:Blood Pressure; D002352:Carrier Proteins / Q000097:blood*; D002463:Cell Membrane Permeability; D004198:Disease Susceptibility; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System
D017920:Antiporters; D002352:Carrier Proteins; C045885:sodium-lithium countertransporter; D012083:Renin
Izuchenie vzaimosviazi mezhdu nekotorymi geneticheskimi i patofiziologicheskimi faktorami, uchastvuiushchimi v reguliatsii arterial'nogo davleniia u bol'nykh gipertonicheskoĭ bolezn'iu.