title: The influence of the surface energy and roughness of implants on bone resorption.
abstract: We investigated the possibility that the macrophages which are seen around implants may stimulate bone resorption and cause loosening. We found that macrophages release mediators that stimulate bone resorption, and that the amount of resorption increased by between 2.5 and 10 times when the macrophages adhered to a foreign surface. This bone resorption depended on the surface energy and roughness of the foreign surface, varying with these physical properties rather than with the chemical nature of the material. It is concluded that loosening of orthopaedic implants is likely to be influenced by the surface energy and roughness of the implant.
authors.affiliation: Orthopaedic Research Unit, University of Cambridge, Addenbrooke's Hospital, England.
authors.forename: D W
authors.initials: DW
authors.lastname: Murray
authors.forename: T
authors.initials: T
authors.lastname: Rae
authors.forename: N
authors.initials: N
authors.lastname: Rushton
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000209:etiology / Q000503:physiopathology*; D002448:Cell Adhesion; D002478:Cells, Cultured; D015232:Dinoprostone / Q000378:metabolism; D004853:Epoxy Resins; D005549:Foreign-Body Reaction / Q000209:etiology / Q000503:physiopathology*; D008264:Macrophages / Q000378:metabolism / Q000502:physiology; D008768:Methylmethacrylates; D051379:Mice; D011095:Polyethylenes; D011138:Polytetrafluoroethylene; D019736:Prostheses and Implants / Q000009:adverse effects*; D013193:Stainless Steel; D013499:Surface Properties
chemical_list: D004853:Epoxy Resins; D008768:Methylmethacrylates; D011095:Polyethylenes; D013193:Stainless Steel; D011138:Polytetrafluoroethylene; D015232:Dinoprostone