[Insulin and glucocorticoid binding by blood cell receptors after hydrocortisone administration in rabbits].
Repeated i.v. administration of hydrocortisone (10 mg/kg) revealed an increase in the resistance against insulin although endogenous corticosterone was decreased in 33 male rabbits. The insulin- and dexamethasone-binding receptors of erythrocytes and mononuclear leucocytes. changed after 3-7 hydrocortisone injections, the binding increasing for insulin and diminishing for dexamethasone.
Tikhonova
N E
NE
Tatarinova
G Sh
GSh
D000818:Animals; D001773:Blood Cells / Q000187:drug effects / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D003345:Corticosterone / Q000097:blood; D003907:Dexamethasone / Q000097:blood; D005938:Glucocorticoids / Q000097:blood*; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000097:blood*; D011817:Rabbits; D011972:Receptor, Insulin / Q000187:drug effects / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
D001786:Blood Glucose; D005938:Glucocorticoids; D007328:Insulin; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone; D011972:Receptor, Insulin; D003345:Corticosterone; D006854:Hydrocortisone
Sviazyvanie insulina i gliukokortikoidov retseptorami kletok krovi posle vvedeniia krolikam gidrokortizona.