title: [Immune granulocytopenia in children].
abstract: Immune neutropenia in infancy comprises alloimmune neutropenia and autoimmune neutropenia. Both diseases are caused by granulocyte-specific antibodies. Patients are newborns and children, often being younger than three years. Neutropenia usually leads to recurrent mild bacterial infections. Beside the blood count and the bone-marrow smear demonstration of granulocyte-specific antibodies is typical. As neutropenia is self-limiting, most patients require only conservative management. In more severe cases interventions with high-doses of intravenous immunoglobulin or corticoid-therapy are indicated.
authors.affiliation: Institut für Klinische Immunologie und Transfusionsmedizin, Justus-Liebig-Universität Giessen.
authors.forename: J
authors.initials: J
authors.lastname: Bux
authors.forename: C
authors.initials: C
authors.lastname: Mueller-Eckhardt
mesh_terms: D000380:Agranulocytosis / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007958:Leukocyte Count; D009503:Neutropenia / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D001324:Autoantigens
vernacular_title: Immungranulozytopenien im Kindesalter.