Increase of neuropeptide Y-like immunoreactivity in the paraventricular nucleus of fasting rats.
The paraventricular nucleus (PVH) of the hypothalamus is a key region for the control of food intake. It presents a very high neuropeptide Y (NPY)-like positive innervation. In this paper we have studied the modifications of NPY-positive innervation in the PVH of 72 h starved rats vs control rats by means of semiquantitative immunocytochemistry. We observed a significant increase of NPY-like immunoreactivity in fasting rats. This result suggests a physiological role of NPY in the food intake regulation at the PVH level.
Calzá
L
L
Institute of Human Physiology, Cagliari, Italy.
Giardino
L
L
Battistini
N
N
Zanni
M
M
Galetti
S
S
Protopapa
F
F
Velardo
A
A
D000818:Animals; D005215:Fasting; D005455:Fluorescent Antibody Technique; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D009478:Neuropeptide Y