Dispersed polaron simulations of electron transfer in photosynthetic reaction centers.
A microscopic method for simulating quantum mechanical, nuclear tunneling effects in biological electron transfer reactions is presented and applied to several electron transfer steps in photosynthetic bacterial reaction centers. In this "dispersed polaron" method the fluctuations of the protein and the electron carriers are projected as effective normal modes onto an appropriate reaction coordinate and used to evaluate the quantum mechanical rate constant. The simulations, based on the crystallographic structure of the reaction center from Rhodopseudomonas viridis, focus on electron transfer from a bacteriopheophytin to a quinone and the subsequent back-reaction. The rates of both of these reactions are almost independent of temperature or even increase with decreasing temperature. The simulations reproduce this unusual temperature dependence in a qualitative way, without the use of adjustable parameters for the protein's Franck-Condon factors. The observed dependence of the back-reaction on the free energy of the reaction also is reproduced, including the special behavior in the "inverted region."
Warshel
A
A
Department of Chemistry, University of Southern California, Los Angeles 90007.
Chu
Z T
ZT
Parson
W W
WW
D001426:Bacterial Proteins / Q000378:metabolism*; D004579:Electron Transport; D007700:Kinetics; D008956:Models, Chemical; D010788:Photosynthesis; D045322:Photosynthetic Reaction Center Complex Proteins; D012241:Rhodopseudomonas / Q000378:metabolism; D013816:Thermodynamics
D001426:Bacterial Proteins; D045322:Photosynthetic Reaction Center Complex Proteins