title: Comparison of five antimelanoma antibodies for identification of melanocytic cells on tissue sections in routine dermatopathology.
abstract: Five antimelanoma antibodies used on routinely processed tissue sections have been compared for their value in identifying both benign and malignant melanocytic lesions. Antibodies to S-100 protein, NKIC3, HMB45, HMB50, and FKH1 were used. S-100 protein was polyclonal, but the others were monoclonal. The tissue was fixed in neutral buffered formalin and included sections from 15 primary melanomas, 5 secondary melanomas, 10 dysplastic nevi, and 10 compound nevi. Antibodies HMB45 and NKIC3 showed the greatest degree of sensitivity.
authors.affiliation: Department of Dermatology, University of Glasgow, Scotland.
authors.forename: W
authors.initials: W
authors.lastname: Thomson
authors.forename: R M
authors.initials: RM
authors.lastname: MacKie
mesh_terms: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D006801:Humans; D007124:Immunoenzyme Techniques; D008545:Melanoma / Q000276:immunology / Q000473:pathology*; D009506:Nevus / Q000276:immunology / Q000473:pathology*; D009418:S100 Proteins / Q000276:immunology; D014407:Tumor Cells, Cultured
chemical_list: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D009418:S100 Proteins