title: Italian multicenter study on the treatment of chronic obstructive lung disease with bromhexine. A double-blind placebo-controlled trial.
abstract: 237 out-patients suffering from chronic obstructive lung disease (COLD) were selected from 7 Italian clinical centers. They were randomly allocated to either placebo or bromhexine 30 mg b.i.d. p.o., in a double-blind fashion. Sputum volume and quality, facility of expectoration, cough, dyspnea, auscultatory thoracic symptoms, forced expiratory volume, peak expiratory flow rate and residual volume were evaluated. Bromhexine showed a statistically significant therapeutic activity in comparison to placebo. This action was rapid, marked and effective in determining a modulation of bronchial secretions.
authors.affiliation: Institute of Pulmonary Medicine and Surgery, University of Genoa, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Valenti
authors.forename: G
authors.initials: G
authors.lastname: Marenco
mesh_terms: D000328:Adult; D000368:Aged; D001964:Bromhexine / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007558:Italy; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D016032:Randomized Controlled Trials as Topic; D012115:Residual Volume / Q000187:drug effects; D013183:Sputum / Q000187:drug effects / Q000378:metabolism
chemical_list: D001964:Bromhexine