[Vaginal estradiol and progesterone in climacteric therapy].
Absorption of suppositories containing 0.25 mg micronized oestradiol and 10 mg micronized progesterone was followed over a period of 24 hours in seven postmenopausal women. The peak concentration was achieved after at least six hours and was 345-2,275 pmol/l for oestradiol and 2.0-11.1 nmol/l for progesterone. Treatment for ten days did not alter the rate of absorption. Ten further postmenopausal patients with subjective menopausal symptoms received one suppository daily for three months. None had vasomotor menopausal complaints after three months and many stated that there were effects on mental and urogenital symptoms. One patient abandoned treatment after two months, probably on account of hormone overdosage. No changes in the serum lipid concentration were observed. Seven patients had no vaginal haemorrhage or had only occasional days with spotting. A more extensive and prolonged investigation would be of interest in view of the influence of the suppositories on the endometrial mucosa.
Pedersen
O D
OD
Jensen
H K
HK
D002979:Climacteric / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011374:Progesterone / Q000008:administration & dosage*; D013488:Suppositories; D014621:Vagina
D013488:Suppositories; D011374:Progesterone; D004958:Estradiol
Vaginal østradiol og progesteron ved behandling af klimakteriet.