[In vitro effect of combinations of daunorubicin and antibiotics against various bacterial strains].
The associations of daunorubicin with various antibiotics were studied by the broth dilution method ("checkboard" technic). The FIC Index were calculated to evaluate the effect of the various combinations. Antibiotics tested were chosen according to the bacterial species: vancomycin, cefotaxime, oxacillin, tobramycin, rifampicin against 15 isolates of Staphylococcus, ampicillin, piperacillin, vancomycin, rifampicin against 10 isolates of enterococci, piperacillin, ofloxacin, tobramycin against 5 E. coli strains. No antagonistic effect was observed whatever the antibiotic or bacterial strain. Against enterococci, all combinations showed a synergistic or additive effect, the most pronounced effect being demonstrated with rifampicin (FIC Index value around 0.3). Among the combinations tested against Staphylococcus, the combination daunorubicin + tobramycin demonstrated synergy against all but 1 strain tested, the combinations including oxacillin, cefotaxime or rifampicin showed a synergistic or additive effect, combinations including vancomycin showed addition or no drug interaction. Antibiotics tested against E. coli gave a synergistic combined drug effect in some cases, more often an additive effect, some time no interaction, depending on the strain.
Fourche
J
J
Laboratoire de Bactériologie, Service, Groupe Hospitalier Sud Xavier, Arnozan, Pessac.
Maugein
J
J
Pellegrin
J L
JL
Mormede
M
M
D000900:Anti-Bacterial Agents; D003630:Daunorubicin / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D006801:Humans; D013210:Staphylococcus / Q000187:drug effects*; D013291:Streptococcus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D003630:Daunorubicin
Activité in vitro des associations daunorubicine et antibiotiques sur diverses espèces bactériennes.