[Neurochemical perspectives of the function of monoamine oxidases].
Monoamine oxidase (MAO) and its subtypes MAO-A and MAO-B show different distribution in post mortem human brain areas. While MAO-B is the predominant type in glial tissue, intraneuronal MAO is either of type A (locus coeruleus, only 10% of substantia nigra neurons stain MAO-A), while raphe neurons contain entirely MAO-B. Inhibition of MAO-subtypes leads to accumulation of biogenic amines in glial tissue while there is a selective intraneuronal influence differing between various brain areas. Generation of toxic end-products (eg. aldehydes, hydrogen peroxide, ammonia) may contribute to trigger or at least to progress Parkinson's disease.
Riederer
P
P
Klinische Neurochemie, Univ-Nervenklinik, Würzburg.
Konradi
C
C
Hebenstreit
G
G
D000818:Animals; D001921:Brain / Q000201:enzymology*; D006801:Humans; D007527:Isoenzymes / Q000502:physiology*; D008995:Monoamine Oxidase / Q000502:physiology*; D009474:Neurons / Q000201:enzymology; D010300:Parkinson Disease / Q000201:enzymology*
D007527:Isoenzymes; D008995:Monoamine Oxidase
Neurochemische Perspektiven zur Funktion der Monoaminoxidase.