title: ets-1 and ets-2 proto-oncogene expression in human leukemia cells and cell lines.
abstract: c-ets-1 and c-ets-2 are 2 proto-oncogenes known to be possibly involved in some human myelomonocytic leukemias. However, very few studies concern c-ets-1 and c-ets-2 RNA expression in human hematologic malignancies. We have studied 18 leukemic patients, and 10 cell lines for their ets RNA contents. c-ets-1 was strongly expressed in 5 and c-ets-2 in 8 of the 18 patients. All the cell lines expressed both c-ets-1 and c-ets-2 RNAs. This expression was highly variable from one patient to another, and from one cell line to another, regardless of the cellular leukemia subtype. The variability of this expression in patients may reflect differences in the proliferative potential of leukemic cells.
authors.affiliation: Laboratoire d'Immunologie et Virologie des Tumeurs, INSERM U152, Hôpital Cochin, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Dreyfus
authors.forename: F
authors.initials: F
authors.lastname: Picard
authors.forename: S
authors.initials: S
authors.lastname: Gisselbrecht
authors.forename: B
authors.initials: B
authors.lastname: Varet
authors.forename: P E
authors.initials: PE
authors.lastname: Tambourin
authors.forename: S
authors.initials: S
authors.lastname: Fichelson
mesh_terms: D000328:Adult; D000368:Aged; D015342:DNA Probes; D004268:DNA-Binding Proteins; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D000090063:Proto-Oncogene Mas; D050784:Proto-Oncogene Protein c-ets-1; D050787:Proto-Oncogene Protein c-ets-2; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D050783:Proto-Oncogene Proteins c-ets; D012333:RNA, Messenger / Q000235:genetics; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D014407:Tumor Cells, Cultured
chemical_list: D015342:DNA Probes; D004268:DNA-Binding Proteins; C107465:ERF protein, human; C494041:ETS1 protein, human; C494069:ETS2 protein, human; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D050784:Proto-Oncogene Protein c-ets-1; D050787:Proto-Oncogene Protein c-ets-2; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D012333:RNA, Messenger; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors