[The behavior of hGH (human growth hormone) and somatomedin C following anesthesia induction with propofol in comparison with diazepam and thiopental].
It was the aim of present study to examine possible interactions between human growth hormone (hGH) and Somatomedin C (SmC), when inducting anaesthesia with propofol in healthy patients. Moreover these effects of propofol should be compared with that of diazepam and thiopentone. 30 patients scheduled for elective plastic-surgery were divided randomly into 3 groups. Induction of anaesthesia was performed in group 1 with diazepam, in group 2 with thiopentone and in group 3 with propofol. Measurements of hGH, SmC as well as blood glucose were performed at 4 different given times: (1.) preoperatively, (2.) 15 minutes, (3.) 30 minutes, (4.) 60 minutes after inducting anaesthesia. Diazepam and thiopentone lead to increases in hGH secretion already in a very early phase after induction of anesthesia (15 minutes) and remained on elevated level. Concentrations of Somatomedin C, as well as of blood glucose, however, remained unchanged during the whole observation period. In comparison to that findings propofol did not show any influence on hGH and consecutively on Somatomedin C activity at any time. Based on our results we can conclude that propofol should be the induction-agent of choice predominantly when anaesthetizing patients with unknown hormonal state (outpatients scheduled for operation).
Luger
T J
TJ
Klinik für Anaesthesie und Allgemeine Intensivmedizin, Universität Innsbruck.
Fässler
R
R
Gottardis
M
M
Koller
W
W
Mutz
N
N
D000328:Adult; D000768:Anesthesia, General; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D003975:Diazepam; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007260:Infusion Pumps; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D015742:Propofol; D016032:Randomized Controlled Trials as Topic; D013002:Somatomedins / Q000378:metabolism*; D013874:Thiopental
D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D013874:Thiopental; D003975:Diazepam; D015742:Propofol
Das Verhalten von hGH (Wachstumshormon, Human Growth Hormone) und Somatomedin C nach Narkoseeinleitung mit Propofol im Vergleich zu Diazepam und Thiopental.