Surgical manoeuvres to reduce the impact of corneal allograft rejection.
Allograft rejection is the major obstacle to successful corneal transplantation in high-risk cases. The risk factors are well recognized. Within the high-risk group, surgeons can influence graft survival by MHC antigen matching, by immunosuppression, by decreasing the number of antigen-presenting cells gaining access to the graft, and by avoiding up-regulation of MHC expression through the suppression of post-operative inflammation.
Coster
D J
DJ
Department of Ophthalmology, Flinders University of South Australia, Adelaide.
Williams
K A
KA
D000818:Animals; D003315:Cornea / Q000601:surgery; D016039:Corneal Transplantation; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D011182:Postoperative Care / Q000379:methods; D011817:Rabbits; D012307:Risk Factors; D014181:Transplantation Immunology