Screening an asymptomatic population for colorectal cancer.
The best prospect of realizing a reduction in mortality from colorectal cancer appears to be by presymptomatic detection in a screened population. Presently, the only feasible method of mass population screening is by the detection of faecal occult blood and it is encouraging that all the major trials demonstrate that asymptomatic malignancy may be detected in this way. Furthermore, the screen-detected cancers are generally at an earlier pathological stage than those appearing in control populations. However, a note of caution is required. At the present time it is too early to demonstrate a reduction in mortality from the disease and there is evidence of a length bias, with more of the screen-detected cancers being well differentiated. The results of the large controlled trials will enable the benefits of screening to be viewed objectively and a recommendation for, or against, screening to be made.
Hardcastle
J D
JD
Thomas
W M
WM
D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000517:prevention & control*; D003718:Denmark; D004724:Endoscopy; D006801:Humans; D008403:Mass Screening; D006113:United Kingdom