title: The evaluation of isoxsuprine hydrochloride for the treatment of navicular disease: a double blind study.
abstract: A randomised double-blind clinical trial of 28 horses was undertaken to evaluate the efficacy of isoxsuprine hydrochloride at four different doses:- 0.0 mg/kg bodyweight (bwt) (placebo), 0.6 mg/kg bwt, 1.2 mg/kg bwt and 1.8 mg/kg bwt for treatment of navicular disease. The results showed that horses treated with isoxsuprine hydrochloride (N = 22) responded significantly with respect to clinical assessment score (P less than 0.01) when compared with the control group (N = 6). Furthermore, there were no dose-related differences in the responses of the horses treated with increasing levels of isoxsuprine. No correlation was found between radiological evidence of the extent of navicular disease and severity of lameness or response to treatment.
authors.affiliation: Department of Clinical Sciences and Biomedical Sciences, Colorado State University, Fort Collins.
authors.forename: A S
authors.initials: AS
authors.lastname: Turner
authors.forename: C M
authors.initials: CM
authors.lastname: Tucker
mesh_terms: D000284:Administration, Oral / Q000662:veterinary; D000818:Animals; D002062:Bursitis / Q000188:drug therapy / Q000662:veterinary; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005534:Foot Diseases / Q000188:drug therapy / Q000662:veterinary; D005552:Forelimb; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007556:Isoxsuprine / Q000008:administration & dosage / Q000627:therapeutic use*; D007794:Lameness, Animal / Q000188:drug therapy*; D010000:Osteitis / Q000188:drug therapy / Q000662:veterinary*; D011897:Random Allocation
chemical_list: D007556:Isoxsuprine