[Non-invasive follow-up control of tumor therapy following chemotherapy using 31P-MR spectroscopy in whole body tomography].
The 31P Magnetic Resonance Spectroscopy allows to monitor noninvasively and in vivo the energy and phospholipid metabolism of tissue. At present the high technical demand prevents the application of this new modality in the clinical routine. By means of some cases the advantages and limitations of the 31P-MRS are demonstrated. Recent results show that 31P-MRS monitors effects on the metabolism of tumor cells as early as two days after onset of chemotherapy. Further clinical studies and technical developments are necessary to render 31P-MRS a clinic routine examination.
Semmler
W
W
Deutsches Krebsforschungszentrum, Institut für Radiologie und Pathophysiologie, Heidelberg.
Bachert-Baumann
P
P
Gückel
F
F
Gademann
G
G
Zabel
H J
HJ
van Kaick
G
G
D003196:Computer Graphics; D004734:Energy Metabolism / Q000187:drug effects*; D005500:Follow-Up Studies; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation*; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism*; D012815:Signal Processing, Computer-Assisted; D012983:Soft Tissue Neoplasms / Q000188:drug therapy*; D012984:Software
D010725:Phosphocreatine; D010758:Phosphorus
Nicht-invasive Tumortherapieverlaufskontrolle nach Chemotherapie mit Hilfe der 31P-MR-Spektroskopie an einem Ganzkörpertomographen.