Portal blood flow: measurement with MR imaging.
Portal blood flow was measured by means of direct bolus imaging (DBI), a method of measuring flow velocity with magnetic resonance imaging. DBI allows immediate visualization of fluid movement, thereby enabling calculation of a flow velocity from fluid displacement. In a study of 14 healthy male volunteers, portal blood flow was measured with electrocardiographic gating during the 18 seconds subjects could suspend respiration. These measurements showed a close correlation (r = .968) with those obtained by means of Doppler ultrasound (US). Increases in portal blood flow after oral administration of ethanol and glucose were measured with DBI. Glucose caused a statistically greater increase in portal blood flow volume in healthy control subjects than in patients with chronic hepatitis. Blood sugar, on the other hand, showed a significantly greater increase in these patients, possibly reflecting the greater vascular resistance of the liver. DBI is a useful noninvasive method of measuring portal blood flow without the limitations imposed on Doppler US by obesity and intestinal gas.
Tamada
T
T
First Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
Moriyasu
F
F
Ono
S
S
Shimizu
K
K
Kajimura
K
K
Soh
Y
Y
Kawasaki
T
T
Kimura
T
T
Yamashita
Y
Y
Someda
H
H
D001783:Blood Flow Velocity / Q000187:drug effects; D001810:Blood Volume; D002908:Chronic Disease; D000431:Ethanol / Q000494:pharmacology; D005951:Glucose Tolerance Test; D006505:Hepatitis / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008961:Models, Structural; D011168:Portal System / Q000502:physiology* / Q000503:physiopathology; D011169:Portal Vein / Q000502:physiology; D014463:Ultrasonography
D000431:Ethanol