title: A multicenter, randomized, double-blind study comparing once-daily bedtime administration of famotidine and ranitidine in the short-term treatment of active duodenal ulcer.
abstract: The efficacy and safety of famotidine and ranitidine in the treatment of active duodenal ulcer were compared in a multicenter, randomized double-blind study. The study was carried out at 5 centers and involved a total of 143 patients with endoscopically documented active duodenal ulcer. The patients received either famotidine (1 40 mg tablet at night) or ranitidine 2 150 mg tablets at night). Endoscopic examinations were performed at 4 and 6 weeks of active treatment. Day and nocturnal pain were also monitored, and the laboratory and clinical profiles evaluated. One hundred and thirty-three patients fulfilled the evaluation criteria (66 patients in the famotidine group and 67 in the ranitidine group). Healing rates at weeks 4 or 6 of treatment showed no significant differences between the famotidine group and the ranitidine group. The healing rates were 78% at week 4 and 96% at week 6 in the famotidine group, and 76% at week 4 and 95% at week 6 in the ranitidine group. Similar results were observed in both treatment groups with regard to pain resolution, decrease in antacid intake and safety profile.
authors.affiliation: Hospital Gregorio Marañón, Madrid.
authors.forename: R
authors.initials: R
authors.lastname: Alcalá Santaella
authors.forename: J
authors.initials: J
authors.lastname: Guardia
authors.forename: J
authors.initials: J
authors.lastname: Pajares
authors.forename: J
authors.initials: J
authors.lastname: Pique
authors.forename: L
authors.initials: L
authors.lastname: Pita
authors.forename: E
authors.initials: E
authors.lastname: Alvárez
authors.forename: P
authors.initials: P
authors.lastname: Castellanos
authors.forename: L
authors.initials: L
authors.lastname: Guarner
authors.forename: J
authors.initials: J
authors.lastname: Ortiz
authors.forename: R
authors.initials: R
authors.lastname: Pesquera
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000188:drug therapy*; D015738:Famotidine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011897:Random Allocation; D011899:Ranitidine / Q000008:administration & dosage* / Q000627:therapeutic use; D013844:Thiazoles / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000897:Anti-Ulcer Agents; D013844:Thiazoles; D015738:Famotidine; D011899:Ranitidine