Current problems associated with toxicity evaluation of medical device materials and future research needs.
The application of toxicology to the evaluation of medical device materials is reviewed. Strengths and weaknesses of systemic and local toxicity models are described. Developments needed to improve the methodology and predictability of assays for immunotoxicity and particulate toxicity are identified. Emerging methods are introduced for assessing adhesion, fibrosis, and blood compatibility.
Northup
S J
SJ
Baxter Healthcare, Inc., Round Lake, Illinois 60073.
D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D004864:Equipment and Supplies; D006801:Humans
D001672:Biocompatible Materials