title: Effect of exogenous prostaglandin E2 on plasma antidiuretic hormone in normal man. Role of angiotension II.
abstract: To verify if exogenous prostaglandin E2 (PGE2) is able to release antidiuretic hormone (ADH) and if endogenous angiotensin II plays a role in this eventual PGE2-induced stimulation of vasopressin, increasing doses of PGE2 were infused in 6 normal volunteers before (PGE2 study) and after the administration of 100 mg of captopril (captopril study). PGE2, even at an infusion rate of 40 and 60 ng/kg/min, did not modify blood pressure when it was infused alone; a significant fall of blood pressure was observed, in contrast, in the captopril study. PGE2 alone doubled the plasma levels of ADH. One hour after the subjects had been pre-treated with captopril, plasma levels of ADH fell by about 38%, then they increased by about 60% during the infusion of PGE2. These results suggest that in normal man endogenous angiotensin II is an important non-osmotic regulator of plasma ADH and that exogenous PGE2 can stimulate maximally the release of ADH only when the renin-angiotensin system is not impaired.
authors.affiliation: Ospedale di Leno, Istituto di Chimica, Università di Brescia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Usberti
authors.forename: A
authors.initials: A
authors.lastname: Gargiulo
authors.forename: E
authors.initials: E
authors.lastname: Comberti
authors.forename: S
authors.initials: S
authors.lastname: Campisi
authors.forename: C
authors.initials: C
authors.lastname: Poiesi
authors.forename: M
authors.initials: M
authors.lastname: Brognoli
authors.forename: C
authors.initials: C
authors.lastname: Doregatti
authors.forename: M
authors.initials: M
authors.lastname: Rondina
authors.forename: A
authors.initials: A
authors.lastname: Zaneboni
authors.forename: S
authors.initials: S
authors.lastname: Ghielmi
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D000527:Alprostadil / Q000097:blood / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology; D002395:Catecholamines / Q000652:urine; D004359:Drug Therapy, Combination; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood; D014667:Vasopressins / Q000097:blood*
chemical_list: D002395:Catecholamines; D014667:Vasopressins; D000450:Aldosterone; D002216:Captopril; D012083:Renin; D000527:Alprostadil