title: Serum thymic hormone thymulin activity is normal in children with asthma.
abstract: In asthma, it has been hypothesized that suppressor T-lymphocytes play a protective role and have been reported to be functionally abnormal. Thymic hormone thymulin plays a role in the differentiation of T-lymphocytes and plasmatic thymulin concentration and is related to the functional state of the thymus. To assess the participation of the thymus in the impairment of T-lymphocyte function, we measured plasma thymulin activity in children with allergic asthma (N = 40). The plasma thymulin activity was compared with plasma thymulin activity of children with nonallergic asthma (N = 6), children with atopic dermatitis (N = 9) or allergic rhinitis (N = 7), and in age-matched healthy control children (N = 18) (age range of children studied, 2 to 19 years). Thymulin activity was found within the normal range (1/16 to 1/64) in all control children and in all children with allergic asthma and allergic rhinitis, as well as in all children with intrinsic asthma and atopic dermatitis. Our findings are at variance with the low thymulin activity previously reported in allergic asthma, and we could not explain these discrepancies. (Both studies used the same bioassay, and the population studied did not appear to be different.) T-lymphocyte abnormalities in subjects with asthma must be assessed by other means than measurement of thymic function.
authors.affiliation: Hôpital Cochin, Département de Pneumologie, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Lurie
authors.forename: M
authors.initials: M
authors.lastname: Chaussain
authors.forename: F
authors.initials: F
authors.lastname: Raynaud
authors.forename: G
authors.initials: G
authors.lastname: de Montis
authors.forename: G
authors.initials: G
authors.lastname: Strauch
authors.forename: A
authors.initials: A
authors.lastname: Lockhart
authors.forename: J
authors.initials: J
authors.lastname: Marsac
authors.forename: M
authors.initials: M
authors.lastname: Dardenne
mesh_terms: D000293:Adolescent; D000818:Animals; D001249:Asthma / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007073:Immunoglobulin E / Q000378:metabolism; D007223:Infant; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012882:Skin Tests; D013601:T-Lymphocytes / Q000503:physiopathology; D013935:Thymic Factor, Circulating / Q000378:metabolism*; D013951:Thymus Hormones / Q000378:metabolism*
chemical_list: D013951:Thymus Hormones; D007073:Immunoglobulin E; D013935:Thymic Factor, Circulating