Mutagenic action of heavy ions on Escherichia coli cells.
Induction of direct mutations in the lactose operon of E. coli cells by gamma-radiation and accelerated heavy ions with different LET was studied. The experiments were performed with the wild-type PolA and LexA strains. A quadratic dependence of the mutation rate on the dose of different radiations for the wild-type strain and the PolA mutant was observed. However, different types of radiation showed different relative genetic effectivenesses (RGE). The dependence of RGE on LET for the wild-type and PolA strain has a maximum. A LexA strain showed much reduced mutation rates and a linear dose response. The RGE decreased with increasing LET of ionizing radiation.
Tokarova
B
B
Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Moscow, U.S.S.R.
Amirtayev
K G
KG
Kozubek
S
S
Krasavin
E A
EA
D001426:Bacterial Proteins / Q000235:genetics; D004256:DNA Polymerase I / Q000235:genetics; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D004735:Energy Transfer; D004926:Escherichia coli / Q000235:genetics; D005720:Gamma Rays; D007763:Lac Operon; D009154:Mutation; D012697:Serine Endopeptidases; D000099160:LexA Repressor Protein
D001426:Bacterial Proteins; D004256:DNA Polymerase I; D012697:Serine Endopeptidases; D000099160:LexA Repressor Protein