Histologic findings of Hailey-Hailey disease in a patient with bullous pemphigoid.
The association of bullous pemphigoid with other immune-mediated diseases has been described; however, coexistence with other bullous dermatoses is unusual. We describe a patient with longstanding localized bullous pemphigoid and the recent finding of a Hailey-Hailey-like histologic pattern in a biopsy specimen obtained at a site of active pemphigoid involvement, as confirmed by immunofluorescence studies. Although this case suggests the possibility of coexistence of two bullous diseases, the Hailey-Hailey-like pattern more likely represents an incidental microscopic finding or a solitary acantholytic lesion.
Mehregan
D A
DA
Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
Umbert
I J
IJ
Peters
M S
MS
D000368:Aged; D000369:Aged, 80 and over; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D010391:Pemphigoid, Bullous / Q000150:complications / Q000473:pathology*; D010392:Pemphigus / Q000150:complications / Q000473:pathology*; D012872:Skin Diseases, Vesiculobullous / Q000473:pathology*