title: [Cardiotoxicity induced by 5-fluorouracil. Review of the literature].
abstract: 5-fluorouracil is potentially cardiotoxic to man. To date, 47 patients have been reported with undesired heart disorders after the administration of this cytotoxic drug. The incidence of cardiotoxicity due to 5-FU is 1.6%. Angina-type precordial pain with electrocardiographic changes suggesting myocardial ischemia is the common clinical feature. Generally it disappears spontaneously or after the use of coronary vasodilators. Acute left ventricular failure, pericarditis and rythm disorders are not often found. The pathogenesis is unknown however, cardiac spasm as well as the direct or indirect effect of the drug on myocardium, are possible responsible mechanisms.
authors.forename: J C
authors.initials: JC
authors.lastname: Blázquez Encinar
authors.forename: M
authors.initials: M
authors.lastname: Martín Jiménez
authors.forename: E
authors.initials: E
authors.lastname: Díaz-Rubio García
authors.forename: J
authors.initials: J
authors.lastname: Almenarez
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006331:Heart Diseases / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005472:Fluorouracil
vernacular_title: Cardiotoxicidad inducida por 5-fluorouracilo. Revisión de la literatura.