title: Genetic regulation of differentiation towards meiosis in the yeast Saccharomyces cerevisiae.
abstract: Normally, meiosis and sporulation in Saccharomyces cerevisiae occur only in diploid strains and only when the cells are exposed to starvation conditions. Diploidy is determined by the mating-type system (the genes MAT, RME1, IME1), whereas the starvation signal is transmitted through the adenylate cyclase - protein kinase pathway (the genes CDC25, RAS2, CDC35 (CYR1), BCY1, TPK1, TPK2, TPK3). The two regulatory pathways converge at the gene IME1, which is a positive regulator of meiosis and whose early expression in sporulating cells correlates with the initiation of meiosis. Sites upstream (5') of IME1 appear to mediate in the repression of the gene by repressors originating from both the mating-type and the cyclase--kinase pathways.
authors.affiliation: Department of Genetics, Hebrew University of Jerusalem, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Simchen
authors.forename: Y
authors.initials: Y
authors.lastname: Kassir
mesh_terms: D000262:Adenylyl Cyclases / Q000502:physiology; D002454:Cell Differentiation / Q000235:genetics; D015966:Gene Expression Regulation, Fungal / Q000502:physiology; D005800:Genes, Fungal / Q000502:physiology; D049770:Genes, Mating Type, Fungal; D008540:Meiosis / Q000235:genetics; D011494:Protein Kinases / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics*; D013172:Spores, Fungal / Q000235:genetics
chemical_list: D011494:Protein Kinases; D000262:Adenylyl Cyclases