Pharmacokinetics of the antidepressant rolipram in healthy volunteers.
1. The pharmacokinetics of rolipram were studied in healthy male volunteers using 3H-rolipram and a radioimmunoassay for measurement of unchanged drug. 2. Rolipram was rapidly and completely absorbed after an oral dose of 1 mg. Bioavailability was 73%. 3. Plasma levels of the unchanged drug declined with a terminal half-life of 2 h. The total clearance of rolipram was 2 ml/min per kg. 4. Labelled rolipram was excreted rapidly and completely. The main route of elimination was via the urine.
Krause
W
W
Schering AG, Berlin, F.R. Germany.
Kühne
G
G
Matthes
H
H
D000284:Administration, Oral; D000928:Antidepressive Agents / Q000493:pharmacokinetics*; D001682:Biological Availability; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011760:Pyrrolidinones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011865:Radioisotope Dilution Technique; D012016:Reference Values; D020889:Rolipram; D014316:Tritium
D000928:Antidepressive Agents; D011760:Pyrrolidinones; D014316:Tritium; D020889:Rolipram