Efficacy of prophylactic antibiotics for the prevention of endomyometritis after forceps delivery.
The purpose of this prospective randomized controlled clinical trial was to determine whether prophylactic antibiotics reduce the incidence of endomyometritis after forceps delivery. Of the 393 patients studied, 192 received 2 gm of intravenous cefotetan after forceps delivery, and 201 patients received no antibiotics. There were seven cases of endomyometritis in the group given no antibiotic and none in the cefotetan group, a statistically significant difference (P less than .01). We conclude that prophylactic antibiotics are effective in reducing the incidence of endomyometritis after forceps delivery. We believe this is the first published study demonstrating this benefit.
Heitmann
J A
JA
Department of Obstetrics and Gynecology, University Hospital of Jacksonville, FL 32209.
Benrubi
G I
GI
D000328:Adult; D015313:Cefotetan / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004716:Endometritis / Q000517:prevention & control*; D005113:Extraction, Obstetrical / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009772:Obstetrical Forceps; D011247:Pregnancy; D011292:Premedication; D011446:Prospective Studies; D011645:Puerperal Infection / Q000517:prevention & control*; D011897:Random Allocation
D015313:Cefotetan