title: Molecular mechanisms of cutaneous aging. Age-associated connective tissue alterations in the dermis.
abstract: Clinically detectable, age-associated cutaneous changes result from two independent processes: chronologic aging and actinic irradiation. Several lines of evidence suggest that these two processes have different biologic, biochemical, and molecular mechanisms. This review summarizes the current understanding of age-associated alterations in the biochemistry and molecular biology of the extracellular matrix.
authors.affiliation: Department of Dermatology, Jefferson Medical College, Philadelphia, PA 19107.
authors.forename: J
authors.initials: J
authors.lastname: Uitto
authors.forename: M J
authors.initials: MJ
authors.lastname: Fazio
authors.forename: D R
authors.initials: DR
authors.lastname: Olsen
mesh_terms: D000368:Aged; D000375:Aging / Q000235:genetics / Q000473:pathology* / Q000502:physiology; D003094:Collagen / Q000096:biosynthesis; D004549:Elastin / Q000096:biosynthesis / Q000235:genetics / Q000648:ultrastructure; D006801:Humans; D012867:Skin / Q000648:ultrastructure*; D012879:Skin Physiological Phenomena; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D003094:Collagen; D004549:Elastin