[Acute effects of propionyl-L-carnitine on anomalies of parietal kinetics of the left ventricle induced by atrial pacing in patients with ischemic heart disease. A bidimensional echocardiographic study].
This double-blind randomized placebo (PL) controlled study was undertaken to evaluate, by 2D echo transesophageal atrial pacing (TAP), the effects of acute iv administration of a new compound propionyl-L-carnitine (PLC) on atrial pacing (AP) induced left ventricular wall motion abnormalities. Twelve male patients with coronary artery disease and normal regional motion at rest, after a preliminary 2D echo-TAP, on the eight and thirteenth day of trial were subjected to 2D echo-TAP 30 min after iv administration of 15 mg/Kg PLC or PL. For analysis, the left ventricle was divided into 11 segments. A wall motion score (WMS), evaluated at 130 b/min and at 150 b/min, was derived by adding together the scores assigned to each segment. Wall motion was graded +2 (normokinetic), +1 (hypokinetic), 0 (akinetic), -1 (dyskinetic). Left ventricular ejection fraction (EF) was evaluated at rest and at 150 b/min. Statistical analysis of the results was performed using a 2-way analysis of variance. The WMS at 130 b/min improved significantly after PLC vs PL from 18.66 +/- 2.46 to 19.50 +/- 2.77 (p less than 0.02). The WMS at 150 b/min improved significantly after PLC vs PL from 16.00 +/- 2.95 to 16.91 +/- 3.47 (p less than 0.01). The EF at rest was not significantly unchanged after PLC. The EF at 150 b/min was significantly different after PLC vs PL, from 53.6 +/- 7.36 to 55.6 +/- 6.45 (p less than 0.05). The blood pressure and the double product at rest and at 150 b/min were not unchanged after PLC.(ABSTRACT TRUNCATED AT 250 WORDS)
Ricci
A
A
Caiati
C
C
Galantino
A
A
Scrutinio
D
D
Valentini
G
G
Chiddo
A
A
Rizzon
P
P
D000328:Adult; D002304:Cardiac Pacing, Artificial; D002331:Carnitine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D004452:Echocardiography; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D013318:Stroke Volume
C003223:propionylcarnitine; D002331:Carnitine
Effetti acuti della propionil-L-carnitina sulle anomalie della cinetica parietale del ventricolo sinistro indotte dal pacing atriale in pazienti con cardiopatia ischemica. Studio ecocardiografico bidimensionale.