[The role of membranes in the mechanisms of the anti-carcinogenic effect of retinoids].
The role of cell membrane structures in the mechanism of anticarcinogenic and antiblastic action of retinoids was reviewed on the basis of the authors' results and data from literature. The retinoid action induced a delay and prevention of malignant neoplasms development, which is shown by various experimental models of carcinogenesis and tumour growth. The regulatory effect of retinoids on the membrane-bound enzymic processes was analyzed as very important in the clarification of the retinoid action mechanisms not only as antipromotor agents, but also as those influencing immediately the initiation stage of the tumour process. Improvement of the A-vitamin status of the organism is an important step in realization of the prophylactic programme of the tumor growth.
Piatchanina
T V
TV
Sidorik
E P
EP
D000818:Animals; D000970:Antineoplastic Agents; D002462:Cell Membrane / Q000187:drug effects* / Q000201:enzymology; D009374:Neoplasms, Experimental / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D012176:Retinoids / Q000494:pharmacology*
D000970:Antineoplastic Agents; D012176:Retinoids
Rol' membran v mekhanizmakh antikantserogennogo deĭstviia retinoidov.