title: Alterations in distribution of cardiac output in experimental diabetes in rats.
abstract: Alterations in blood flow distribution in streptozotocin-induced diabetes in the rat were examined. Blood flow between tissues was estimated by the distribution of radiolabeled microspheres, and a second series of experiments examined skeletal muscle microcirculation by in vivo microscopy. Studies were performed in anesthetized rats 1-8 wk after induction of diabetes. Cardiac index was transiently increased in diabetic animals (29.6 +/- 1.0 ml.min-1.100 g-1) in comparison with control animals (23.0 +/- 1.4 ml.min-1.100 g-1) at 2-wk duration. Cardiac index was similar in both groups of animals at all other time points studied. The increased cardiac index coincided with transiently increased blood flow to diaphragm and abdominal wall and a significant vasodilatation of small cremaster muscle arterioles. Blood flow to skin and some skeletal muscles was thereafter significantly decreased in the diabetic animals. Blood flow (ml.min-1.100 g-1) to the brain and main thoracic and abdominal organs was similar in nonfasting control and diabetic animals throughout the period of study. As a result of hyperplasia, blood flow to the small intestine (%cardiac output) was increased in the diabetic animals (at 4 wk of diabetes, 34.5 +/- 2.1 vs. 17.5 +/- 0.8%, P less than 0.001). Despite reduction in blood flow to the intestine, by dietary restriction, flow to skin and skeletal muscle remained significantly decreased. Insulin treatment, at a dose aimed at preventing body weight loss but maintaining hyperglycemia, led to renal hyperperfusion in comparison with untreated diabetic and control animals. The alterations in regional blood flow appear progressive in nature and are not simply related to each other but may reflect tissue adaptation to the metabolic disorder.
authors.affiliation: Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Victoria, Australia.
authors.forename: M A
authors.initials: MA
authors.lastname: Hill
authors.forename: R G
authors.initials: RG
authors.lastname: Larkins
mesh_terms: D000818:Animals; D001158:Arteries / Q000187:drug effects*; D001160:Arterioles / Q000187:drug effects* / Q000503:physiopathology; D001794:Blood Pressure; D002302:Cardiac Output; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003927:Diet, Diabetic; D006321:Heart / Q000503:physiopathology; D007328:Insulin / Q000494:pharmacology; D007421:Intestine, Small / Q000098:blood supply*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012039:Regional Blood Flow / Q000187:drug effects; D012079:Renal Circulation / Q000187:drug effects; D014655:Vascular Resistance
chemical_list: D007328:Insulin