Protein A protects mice from depletion of biotransformation enzymes and mortality induced by Salmonella typhimurium endotoxin.
Changes in hepatic microsomal mixed-function oxidase enzyme levels (aniline hydroxylase, aminopyrine demethylase, glutathione S-transferase), glutathione content, total sulphydryl content, and plasma enzyme levels of aspartate transaminase, alanine transaminase and alkaline phosphatase were studied in male Swiss albino mice exposed to Salmonella typhimurium endotoxin (50-150 micrograms per mouse, LC50 141.82 micrograms). Animals exposed to the same dose of endotoxin but pretreated with protein A of Staphylococcus aureus (5 micrograms/per mouse) protected the animals from both mortality and depletion of biotransformation enzymes.
Dwivedi
P D
PD
Immunobiology Division, Industrial Toxicology Research Centre, Lucknow, India.
Verma
A S
AS
Mishra
A
A
Singh
K P
KP
Prasad
A K
AK
Saxena
A K
AK
Dutta
K K
KK
Mathur
N
N
Ray
P K
PK
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001427:Bacterial Toxins / Q000633:toxicity*; D001711:Biotransformation / Q000187:drug effects; D005978:Glutathione / Q000032:analysis; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000032:analysis; D012486:Salmonella typhimurium; D013205:Staphylococcal Protein A / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000032:analysis
D001427:Bacterial Toxins; D013205:Staphylococcal Protein A; D013438:Sulfhydryl Compounds; D006899:Mixed Function Oxygenases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D005978:Glutathione