title: The chemical stability of captopril capsules.
abstract: Captopril therapy is effective in the management of congestive heart failure. The development of hypotension, using low or standard doses, frequently precludes many patients from continuing therapy. The use of 1 mg "microdose" captopril capsules has been used for dose titration to avoid complications associated with hypotension. This study evaluated the chemical stability of 1 mg microdose captopril capsules, extemporaneously prepared from commercially available captopril tablets for a period of 60 days which were stored in an amber vial at standard room temperature conditions. Captopril samples were analyzed in triplicate using high pressure liquid chromatographic method on days 0, 30, and 60 following perparation. There was no degradation observed on any of the sampling days. Therefore, the formulation of 1 mg captopril capsules remain stable for a period of 60 days.
authors.affiliation: Hartford Hospital, Department of Clinical Pharmacy, University of Connecticut, Storrs.
authors.forename: R D
authors.initials: RD
authors.lastname: Colucci
authors.forename: R
authors.initials: R
authors.lastname: Auty
authors.forename: J
authors.initials: J
authors.lastname: Scavone
authors.forename: L
authors.initials: L
authors.lastname: Glassner-Cohen
mesh_terms: D002214:Capsules; D002216:Captopril / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D010130:p-Aminohippuric Acid / Q000032:analysis
chemical_list: D002214:Capsules; D002216:Captopril; D010130:p-Aminohippuric Acid