Effect of folic acid supplementation on small-for-gestational-age infants born at term.
The effect of 250 micrograms folic acid (FA)/day or placebo given to 21 small-for-gestational-age infants born at term was studied during the first 3 months of life. The design of the study was double blind with random allocation. No randomization was performed in respect of breast-feeding or formula-feeding with a folate content of 60-70 micrograms/l. No significant differences were observed in haemoglobin concentration, haematocrit, weight and length between FA-supplemented and non-supplemented infants. A negative correlation was demonstrated between gestational age and erythrocyte folate (E-folate) concentration at 1 week. E-folate content was higher when no supplement was given in breast-fed than in formula-fed infants.
Foged
N
N
Department of Paediatrics, Odense University Hospital, Denmark.
Lillquist
K
K
Rolschau
J
J
Blaabjerg
O
O
D001903:Bottle Feeding; D001942:Breast Feeding; D004311:Double-Blind Method; D004920:Erythropoiesis / Q000187:drug effects; D005492:Folic Acid / Q000627:therapeutic use*; D006128:Growth / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D016032:Randomized Controlled Trials as Topic
D005492:Folic Acid