Design of specific mechanism-based inactivators of hepatic and adrenal microsomal cytochromes P-450 responsible for progesterone 21-hydroxylation.
Halpert
J R
JR
Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson 85721.
Jaw
J Y
JY
Johnson
E F
EF
D000311:Adrenal Glands / Q000201:enzymology*; D000818:Animals; D065607:Cytochrome P-450 Enzyme Inhibitors; D006801:Humans; D008861:Microsomes / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology*; D011374:Progesterone / Q000378:metabolism*; D013255:Steroid 21-Hydroxylase / Q000037:antagonists & inhibitors*; D013250:Steroid Hydroxylases / Q000037:antagonists & inhibitors*
D065607:Cytochrome P-450 Enzyme Inhibitors; D011374:Progesterone; D013250:Steroid Hydroxylases; D013255:Steroid 21-Hydroxylase