Effect of ciprofloxacin on human lymphocytes--laboratory studies.
4-Quinolones affect mammalian cellular functions in vitro in several ways. Inhibition of cell proliferation differ widely among 4-quinolones. Ciprofloxacin is one of the most antiproliferative inhibiting cell growth with about 30% at 20 mg/l. Genotoxicity tests with 4-quinolones are probably "false" positive due to an increased [3H]-thymidine uptake not related to DNA damage. Ciprofloxacin at 10 mg/l and up causes significant DNA strand breaks which seemingly are quickly repaired and not causing mutations or cancerogenesis. Ciprofloxacin at 5 mg/l inhibits immunoglobulin production but the growth factor interleukin 2 (IL-2) is increased by 4-quinolones at the same concentration and hyperinduced at higher concentrations. Thus the effects are very contradictory. Increased IL-2 may contribute to CNS side effects.
Forsgren
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A
Department of Medical Microbiology, University of Lund, Malmö General Hospital, Sweden.
Bredberg
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A
Riesbeck
K
K
D002939:Ciprofloxacin / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects*; D004249:DNA Damage; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007376:Interleukin-2 / Q000096:biosynthesis; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D013936:Thymidine / Q000378:metabolism
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007376:Interleukin-2; D002939:Ciprofloxacin; D004247:DNA; D013936:Thymidine