title: [Biosynthesis of oleandomycin by cultures of Streptomyces antibioticus obtained after regeneration and fusion of protoplasts].
abstract: The ability of Streptomyces antibioticus strains to synthesize oleandomycin is studied under the effect of regeneration and fusion of protoplasts. The production of strains-regenerants with an increased (by 30-50%) synthesis of oleandomycin is possible. Regenerants of mutants resistant to the proper antibiotic retain a high level of the oleandomycin synthesis more stably. Variations in the antibiotic-production ability are considered in regenerant populations of various generations.
authors.forename: A A
authors.initials: AA
authors.lastname: Shevchenko
authors.forename: B P
authors.initials: BP
authors.lastname: Matseliukh
authors.forename: I S
authors.initials: IS
authors.lastname: Sobachkina
authors.forename: A F
authors.initials: AF
authors.lastname: Tyshchenko
authors.forename: V M
authors.initials: VM
authors.lastname: Orekhova
mesh_terms: D009827:Oleandomycin / Q000096:biosynthesis*; D011523:Protoplasts; D013302:Streptomyces / Q000378:metabolism*; D013303:Streptomyces antibioticus / Q000378:metabolism*
chemical_list: D009827:Oleandomycin
vernacular_title: Biosintez oleandomitsina kul'turami Streptomyces antibioticus, poluchennymi posle regeneratsii i sliianiia protoplastov.