[Does Ph'-negative chronic myeloleukemia exist?].
The authors have presented the current data on so-called Ph'-negative chronic myeloleukemia (CML). A detailed clinico-hematologic analysis has proved that most of patients with unchanged chromosome 22 have other myeloproliferative disease, most often it is chronic myelomonocytic leukemia. In some CML patients Ph'-chromosome is masked as a result of translocations, in other patients, although chromosome 22 is unchanged, the molecular-genetic marker of CML--chimera bcr/c-abl-gene, is detected on chromosome 22 or some other chromosome. It has been noted that only in rare cases of typical CML characteristic cytogenetic and molecular-genetic changes are absent. Further investigations should be conducted in the group of patients studied.
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D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D002908:Chronic Disease; D006801:Humans; D007621:Karyotyping; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic
Sushchestvuet li Ph'-otritsatel'nyĭ khronicheskiĭ mieloleĭkoz?