Tracheobronchial clearance in asthma-discordant monozygotic twins.
Tracheobronchial clearance and bronchial reactivity were studied in 6 asthma-discordant monozygotic twin pairs, and in 3 concordant pairs as controls. Clearance of 6-microns Teflon particles labeled with 99mTc was followed for 2 h. The results indicate that clearance in the larger airways is usually not severely impaired in mild to moderate asthma, and that it may be increased as well as decreased. Bronchial reactivity correlated with clearance in the nonasthmatics.
Svartengren
M
M
Department of Environmental Hygiene, Karolinska Institute, Stockholm, Sweden.
Ericsson
C H
CH
Philipson
K
K
Mossberg
B
B
Camner
P
P
D000280:Administration, Inhalation; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects / Q000502:physiology; D001249:Asthma / Q000000981:diagnostic imaging / Q000235:genetics* / Q000503:physiopathology; D001980:Bronchi / Q000000981:diagnostic imaging; D004200:Diseases in Twins; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000494:pharmacology; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects / Q000502:physiology*; D011138:Polytetrafluoroethylene / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D013667:Technetium; D014132:Trachea / Q000000981:diagnostic imaging; D014427:Twins; D014430:Twins, Monozygotic; D014797:Vital Capacity / Q000187:drug effects
D008688:Methacholine Compounds; D016210:Methacholine Chloride; D013667:Technetium; D011138:Polytetrafluoroethylene