Increased galactose clearance after liver transplantation: a measure of increased blood flow through the denervated liver?
This study measured the liver blood flow-dependent index of galactose clearance in patients after liver transplantation, to test the hypothesis that liver blood flow is increased in the denervated liver. Eight normal subjects and 16 patients 1 to 8 months after liver transplant were studied. All patients were stable with no evidence of severe rejection at the time of study. Galactose clearance was measured at steady state during continuous infusion of 75 mg per min of 5% galactose. The results show a statistically significant (p less than 0.01) higher average galactose clearance in the transplant patients (1,187 +/- 316 ml per min per m2) compared to the control group (709 +/- 121 ml per min per m2). The major limiting factor in galactose clearance at low concentrations is liver blood flow, and we interpret these data as evidence for increased blood flow in the transplanted liver. Possible mechanisms for the increased galactose clearance are (i) loss of normal vasomotor tone in the denervated liver, or (ii) persistence of abnormal systemic hemodynamics after transplantation. Elucidation of these mechanisms awaits further study.
Henderson
J M
JM
Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322.
Millikan
W J
WJ
Hooks
M
M
Noe
B
B
Kutner
M H
MH
Warren
W D
WD
D000328:Adult; D003714:Denervation; D005690:Galactose / Q000493:pharmacokinetics; D006801:Humans; D008099:Liver / Q000294:innervation; D008102:Liver Circulation; D016031:Liver Transplantation; D008875:Middle Aged; D014463:Ultrasonography; D014654:Vascular Patency
D005690:Galactose