Genetic defects of lysosomal function in animals.
In this article we have described studies using animals with genetic lysosomal defects with particular emphasis on mutant disorders that have contributed toward understanding of pathogenesis and/or management of analogous human conditions. The development of newer strategies in the production and use of animal models will greatly expand the contribution of this resource to biology and medicine.
Patel
S C
SC
Neurology Service, Veterans Administration Medical Center, Newington, Connecticut 06111.
Pentchev
P G
PG
D000818:Animals; D004195:Disease Models, Animal; D008247:Lysosomes / Q000378:metabolism*; D008661:Metabolism, Inborn Errors / Q000378:metabolism*