title: Determination of single and repeated red cell volumes by the indicator dilution method using carbon monoxide as the indicator.
abstract: The use of radioactive isotopes limits clinical applications of blood volume measurement in the ICU. We measured red cell volumes with carbon monoxide-labeled RBC in six dogs and five human volunteers. The measured values obtained on the dogs were compared with the simultaneous measurements with the 51Cr method; the ratio of the carbon monoxide to 51Cr values ranged from 0.86 to 1.17, and the mean ratio was 1.0 +/- 0.1 (SD), r = .93. We infer from these results that the carbon monoxide method has several advantages over the 51Cr method: a) the short labeling time (about 1 min), b) rapidly decreasing background levels of carbon monoxide with FIO2 1.0, and c) repeatability at intervals of several hours.
authors.affiliation: Department of Anesthesiology, Kyoto Prefectural University of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fukui
authors.forename: K
authors.initials: K
authors.lastname: Shigemi
mesh_terms: D000328:Adult; D000818:Animals; D002248:Carbon Monoxide; D002860:Chromium Radioisotopes; D004285:Dogs; D004911:Erythrocyte Volume; D005260:Female; D006801:Humans; D007201:Indicator Dilution Techniques; D008297:Male; D011865:Radioisotope Dilution Technique
chemical_list: D002860:Chromium Radioisotopes; D002248:Carbon Monoxide