title: Hepatic 123I-insulin binding kinetics in non-insulin-dependent (type 2) diabetic patients after i.v. bolus administration.
abstract: Insulin binding kinetics in the liver were studied in non insulin dependent (Type 2) diabetic patients, by i.v. bolus administration of 123I-insulin. Eight Type 2 diabetic patients were compared with six male volunteers. Uptake of 123I-insulin by liver and kidneys was measured by dynamic scintigraphy with a gamma camera during 30 min. Images of liver and kidneys appeared within 2-3 min after administration of 123I-insulin at a dose of 1 mCi (37 MBq). Peak radioactivity for the liver was found 7.5 +/- 0.2 and 6.9 +/- 0.3 min after injection for the healthy and the diabetic subjects, respectively (N.S.). The percentage 123I-insulin hepatic uptake was not significantly different for the diabetic and the healthy subjects. Although a large variation exists for maximal uptake of radioactivity within both groups, the data suggest that binding differences in the liver in Type 2 diabetic patients, as compared to healthy subjects, may not account for hepatic insulin resistance.
authors.affiliation: Department of Endocrinology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Oolbekkink
authors.forename: R J
authors.initials: RJ
authors.lastname: Heine
authors.forename: W
authors.initials: W
authors.lastname: den Hollander
authors.forename: J J
authors.initials: JJ
authors.lastname: Nauta
authors.forename: E A
authors.initials: EA
authors.lastname: van der Veen
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000493:pharmacokinetics*; D007333:Insulin Resistance; D007457:Iodine Radioisotopes; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging
chemical_list: D007328:Insulin; D007457:Iodine Radioisotopes