[Isomeride and treatment of overweight].
Controlled European studies of 1 315 patients in medium (3 month) and long term (6 month, 1 year) trials have shown the efficacy and safety of Isomeride in the treatment of overweight. Three month studies of Isomeride plus diet versus placebo plus diet have shown an average weight loss of 3 kilograms in the first month and 7 kilograms after 3 months treatment in the Isomeride group. The difference with placebo was significant in the first month and increased in the following months. Drop out was similar in both groups. The safety of Isomeride made possible long term treatment of particularly severe refractory cases of overweight. A 6 month English trial confirmed these results and a research programme is underway to assess the value of 1 year and more therapy with Isomeride.
Louvet
J P
JP
Hôpital Purpan, Toulouse.
D004311:Double-Blind Method; D005060:Europe; D005277:Fenfluramine / Q000627:therapeutic use*; D006801:Humans; D007391:International Cooperation; D015337:Multicenter Studies as Topic; D009765:Obesity / Q000188:drug therapy*; D011897:Random Allocation; D013997:Time Factors
D005277:Fenfluramine
Isoméride et traitement des surcharges pondérales.