Development of antiviral drugs for the treatment of AIDS: strategies and prospects.
This review makes it clear that there are numerous possibilities for the development of antiviral drugs for the treatment of AIDS. Drug design based on a profound understanding of specific enzymatic regulatory proteins and structural requirements for virus replication is possible. Information regulating these specific processes is increasing rapidly and will further speed preclinical drug design. Over time, this concerted effort to develop anti-AIDS drugs will radically alter the approach to the design of drugs for the treatment of other diseases.
Haseltine
W A
WA
Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000998:Antiviral Agents / Q000627:therapeutic use*; D004261:DNA Replication; D015195:Drug Design; D005814:Genes, Viral; D015497:HIV-1 / Q000235:genetics / Q000502:physiology; D006801:Humans; D008967:Molecular Biology; D011533:Proviruses / Q000502:physiology; D014158:Transcription, Genetic; D014759:Viral Envelope Proteins / Q000502:physiology
D000998:Antiviral Agents; D014759:Viral Envelope Proteins