Effect of serum from diabetes-prone BB/OK rats on neonatal rat pancreatic islets and islet cell suspensions.
Humoral-mediated cytolytic activity against neonatal rat pancreatic islet cells as well as islets of Langerhans was detected in sera of newly diagnosed diabetic BB/OK rats by measurement of enhanced 51Cr-release or insulin leakage. Beta-cell-specific functions of islet cell suspensions such as insulin secretion and (pro)insulin biosynthesis can be affected by BB rat serum in vitro.
Schröder
D
D
Central Institute of Diabetes, Karlsburg, GDR.
Hehmke
B
B
Klöting
I
I
Besch
W
W
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects; D001323:Autoantibodies / Q000276:immunology; D001798:Blood Proteins / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000276:immunology; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D051381:Rats; D011922:Rats, Mutant Strains
D001323:Autoantibodies; D001798:Blood Proteins; C024211:islet cell antibody