Pancreatic cytoprotection: a survey.
The author gives a brief survey on the concept of cytoprotection, the generation of prostaglandins and the mechanism of their action. The effect of exogenous prostaglandins and the mechanism of their action. The effect of exogenous prostaglandins on pancreatic vasculature, secretion, ductal permeability and their therapeutic effect on experimentally induced acute pancreatitis is discussed. Pancreatic "self-defence" mechanism is also discussed the mechanism of which may be rather different from that of cytoprotection. In such pancreatic "self-defense" mechanism decrease in pancreatic protein synthesis and secretion induced by pancreatic duct ligation or decrease in sensibility of pancreatic acinar cells or their receptors against specific stimulants may participate.
Papp
M
M
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.
D000818:Animals; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D010195:Pancreatitis / Q000517:prevention & control; D011453:Prostaglandins / Q000096:biosynthesis / Q000494:pharmacology*
D011453:Prostaglandins