The role of free radicals in tumor promotion.
A role has been suggested for free radicals and active states of oxygen in tumor promotion. There are a number of lines of support for this hypothesis, but no definitive evidence. The hypothesis has proven of value in leading to the development of models pertinent to understanding the mechanism of action of tumor promoters.
Goldstein
B D
BD
Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854-5635.
Czerniecki
B
B
Witz
G
G
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D005609:Free Radicals; D006801:Humans; D010100:Oxygen / Q000378:metabolism*
D002273:Carcinogens; D005609:Free Radicals; D010100:Oxygen