title: T-zone histiocytes and recurrence of papillary urothelial bladder carcinoma.
abstract: We have studied the histologic distribution and prognostic significance of T-zone histiocytes (TZH) in 89 papillary urothelial bladder carcinomas (PUC), 3 cases of nonspecific cystitis (NC) and 4 cases of follicular cystitis (FC) by immunohistochemical determination of S-100 protein. Nineteen (21.37%) of the PUC cases have been found to have TZH S-100-positive with a variable density intratumor, along the papillary axis, or in the lymphoid aggregates of the vesical wall. All four FC cases were also TZH-positive, with a distribution and density similar to those of follicular dendritic cells of lymph nodes, although none of the 3 NC cases presented TZH. The recurrence-free period was significantly (p less than 0.05) longer in TZH-positive patients.
authors.affiliation: Anatomical Pathology Unit, Faculty of Medicine, University of Cordoba, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Lopez-Beltran
authors.forename: C
authors.initials: C
authors.lastname: Morales
authors.forename: C
authors.initials: C
authors.lastname: Reymundo
authors.forename: M
authors.initials: M
authors.lastname: Toro
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000378:metabolism / Q000473:pathology*; D003556:Cystitis / Q000473:pathology; D006644:Histiocytes / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D011379:Prognosis; D009418:S100 Proteins / Q000032:analysis; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D009418:S100 Proteins