title: Day-long glucose, insulin, and fructose responses of hyperinsulinemic and nonhyperinsulinemic men adapted to diets containing either fructose or high-amylose cornstarch.
abstract: Ten hyperinsulinemic and 11 nonhyperinsulinemic men consumed a typical American diet containing 20% of calories either as fructose or as high-amylose cornstarch for 5 wk in a crossover design to determine their effects on indices of glucose tolerance. Blood glucose, insulin, and fructose were determined before and 30, 60, 90, 120 and 180 min after breakfast, lunch, and dinner. Glucose responses were significantly lower 60 and 120 min and the insulin response lower 60 min after the meals containing fructose. Hyperinsulinemic men showed a tendency toward decreased insulin sensitivity after consuming fructose on the basis of an increased insulin-to-glucose ratio and decreased insulin binding to erythrocytes. These results generally show a beneficial effect of fructose on glucose tolerance; however, recommendations for including large amounts of fructose in the diet should also be based on a complete evaluation of the effect on other metabolic risk factors.
authors.affiliation: Beltsville Human Nutrition Research Center, US Department of Agriculture, MD 20705.
authors.forename: S
authors.initials: S
authors.lastname: Reiser
authors.forename: A S
authors.initials: AS
authors.lastname: Powell
authors.forename: D J
authors.initials: DJ
authors.lastname: Scholfield
authors.forename: P
authors.initials: P
authors.lastname: Panda
authors.forename: M
authors.initials: M
authors.lastname: Fields
authors.forename: J J
authors.initials: JJ
authors.lastname: Canary
mesh_terms: D000328:Adult; D000688:Amylose / Q000008:administration & dosage*; D001786:Blood Glucose / Q000032:analysis*; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004912:Erythrocytes / Q000378:metabolism; D005632:Fructose / Q000008:administration & dosage / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood*; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011972:Receptor, Insulin / Q000097:blood; D013213:Starch / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin; D005632:Fructose; D013213:Starch; D000688:Amylose; D011972:Receptor, Insulin