Platelet activating factor: effects on bronchomotor tone and bronchial responsiveness in human beings.
Platelet-activating factor (PAF) is a newly discovered lipid mediator of inflammation. When inhaled by normal volunteers, it induces bronchoconstriction associated with facial flushing and with a transient fall in circulating neutrophils. Of greater interest is its ability to induce prolonged increases in bronchial responsiveness to methacholine. These observations support an important role for PAF in asthama; the availability of specific PAF antagonists will allow us to test this hypothesis.
Chung
K F
KF
Department of Thoracic Medicine, National Heart and Lung Institute, Brompton Hospital, London, England.
Cuss
F M
FM
Barnes
P J
PJ
D000403:Airway Resistance / Q000187:drug effects; D001249:Asthma / Q000503:physiopathology*; D001985:Bronchial Provocation Tests / Q000379:methods*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D016210:Methacholine Chloride; D008688:Methacholine Compounds; D009130:Muscle, Smooth / Q000503:physiopathology; D010972:Platelet Activating Factor / Q000502:physiology* / Q000031:analogs & derivatives
D008688:Methacholine Compounds; C029271:O-deacetyl platelet activating factor; D010972:Platelet Activating Factor; D016210:Methacholine Chloride