Gonadotropin-releasing hormone infusion interval: importance in pharmacodynamics.
Circulating gonadotropin-releasing hormone (GnRH) levels were measured during and after intravenous infusion intervals ranging from 0.08 minutes to 5 minutes and doses ranging from 1 to 25 micrograms per pulse. In all dose groups (1 vs. 5 vs. 25 micrograms), the peak levels of GnRH decreased from the 0.08 minute to the 5 minute infusion interval. Our results suggest that the infusion interval over which GnRH is administered has profound effects on the amount, duration, and pattern of GnRH measured in the peripheral circulation.
Schmutzler
R
R
Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Medical College of Hampton Roads, Norfolk.
Elkind-Hirsch
K
K
Hahn
D
D
McGuire
J L
JL
Simon
J A
JA
Danforth
D R
DR
Hodgen
G D
GD
D000818:Animals; D004334:Drug Administration Schedule; D005260:Female; D007260:Infusion Pumps; D008253:Macaca mulatta; D008297:Male; D010906:Pituitary Hormone-Releasing Hormones / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics
D010906:Pituitary Hormone-Releasing Hormones