Contributions of experimental tumors to the relationship between carcinogenesis and differentiation.
Brain tumors are experimentally inducible in adult and newborn animals and in the offspring by transplacental administration of brain-specific carcinogens, such as Methylnitrosourea (MNU) and Ethylnitrosourea (ENU). These compounds are quite reliable in producing tumors in the offspring with a well-defined pattern. These NU-induced tumors can be considered an important model-system mainly for the investigation of the early stages in the tumorigenesis of endocranic neoplasias.
Schiffer
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Clinica Neurologica II, Università di Torino, Italy.
D000818:Animals; D001921:Brain / Q000254:growth & development; D001932:Brain Neoplasms / Q000139:chemically induced / Q000473:pathology*; D002454:Cell Differentiation; D005038:Ethylnitrosourea; D008770:Methylnitrosourea; D051381:Rats
D008770:Methylnitrosourea; D005038:Ethylnitrosourea