title: [A study of the proliferative activity of DNA polymerase alpha immunoreactivity in breast cancer].
abstract: DNA polymerase alpha activity is associated with cell proliferation, independently of the cell cycle phase, and a simple and reproducible method for the immunohistochemical demonstration of DNA polymerase alpha has been developed. In an analysis of a total of 76 human breast cancer tissues using this procedure, the clinico-pathological findings revealed that only the estrogen receptor (ER) significantly correlated with the DNA polymerase alpha activity. Therefore, this suggests that ER-negative tumors had a higher proliferative activity.
authors.affiliation: Dept. of Surgery, Kumamoto Municipal Hospital.
authors.forename: R
authors.initials: R
authors.lastname: Nishimura
authors.forename: K
authors.initials: K
authors.lastname: Nagao
authors.forename: M
authors.initials: M
authors.lastname: Matsuda
authors.forename: K
authors.initials: K
authors.lastname: Baba
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: Y
authors.initials: Y
authors.lastname: Ueno
authors.forename: H
authors.initials: H
authors.lastname: Morinaga
authors.forename: H
authors.initials: H
authors.lastname: Nagase
authors.forename: O
authors.initials: O
authors.lastname: Miyayama
authors.forename: T
authors.initials: T
authors.lastname: Hamada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000032:analysis / Q000201:enzymology* / Q000473:pathology; D002455:Cell Division; D004257:DNA Polymerase II / Q000032:analysis / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D011960:Receptors, Estrogen; D004257:DNA Polymerase II