title: The isolation and structure of modified bioactive nucleosides from Jaspis johnstoni.
abstract: Two cytotoxic pyrrolo[2,3-d]pyrimidine nucleosides, toyocamycin and 5-(methoxycarbonyl)tubercidin, have been isolated from the Fijian sponge Jaspis johnstoni. The structures were solved primarily by 13C nmr and mass spectral methods and confirmed by comparison to reported values in the literature. Small amounts of the corresponding aglycones were also isolated.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112.
authors.forename: T M
authors.initials: TM
authors.lastname: Zabriskie
authors.forename: C M
authors.initials: CM
authors.lastname: Ireland
mesh_terms: D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D000970:Antineoplastic Agents / Q000302:isolation & purification; D002176:Candida albicans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure; D011161:Porifera / Q000032:analysis*; D011743:Pyrimidines / Q000302:isolation & purification; D011758:Pyrroles / Q000302:isolation & purification; D013057:Spectrum Analysis; D014127:Toyocamycin / Q000302:isolation & purification* / Q000494:pharmacology; D014372:Tubercidin / Q000031:analogs & derivatives / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D011743:Pyrimidines; D011758:Pyrroles; C062902:5-(methoxycarbonyl)tubercidin; D014127:Toyocamycin; D014372:Tubercidin