title: [ACPA reaction in atypical Wegener's disease. Diagnostic test].
abstract: Clinical and biopsy findings in six patients (aged 29-64 years), suspected of having Wegener's granulomatosis, were not diagnostic. Cardinal signs were skin necroses, isolated deficits of cranial nerves, sudden amaurosis, renal failure with shunt sepsis and lung opacities suspicious of tumour. Only positive tests for anti-cytoplasmatic antibodies (ACPA) in serum made the diagnosis and led to appropriate treatment. This simple yet highly specific immunofluorescence test should be performed in every case of vasculitis of uncertain cause, even if typical clinical signs of Wegener's granulomatosis are at first absent.
authors.affiliation: Medizinische Klinik, Universität Freiburg.
authors.forename: J A
authors.initials: JA
authors.lastname: Rump
authors.forename: H
authors.initials: H
authors.lastname: Laaff
authors.forename: B
authors.initials: B
authors.lastname: Lang
authors.forename: S
authors.initials: S
authors.lastname: Schön
authors.forename: M
authors.initials: M
authors.lastname: Kuhlmann
authors.forename: U
authors.initials: U
authors.lastname: Solzbach
authors.forename: P
authors.initials: P
authors.lastname: Vaith
authors.forename: P
authors.initials: P
authors.lastname: Schollmeyer
authors.forename: H H
authors.initials: HH
authors.lastname: Peter
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012867:Skin / Q000473:pathology
chemical_list: D001323:Autoantibodies
vernacular_title: ACPA-Reaktion bei atypischem Morbus Wegener. Diagnoseweisender Test.