title: Neoplasms metastatic to the mouth, jaws and surrounding tissues.
abstract: 5% of all malignancies involve the oral cavity. One percent of these malignancies are secondary to neoplasms that are usually found below the level of the clavicles. As it is widely accepted that the jaws do not contain a lymphatic system, it is believed that metastases there occur via the blood stream, a fact that is supported by the occurrence of metastatic foci in areas where spongiosa and slowing of the circulation favour the entrapment of metastatic emboli. This however does not explain why most of the metastases occur in the lower jaw (and in particular in the premolar-molar area) and not in the maxilla, where the spongiosa is more abundant. Batson's plexus has also been mentioned as a possible route of metastasis to the head and neck, thus explaining why, in some cases of metastases, the lungs are not involved, as the blood has not been filtered through the pulmonary bed before reaching the head and neck. In our review of the literature we found 422 metastatic lesions in the mouth, jaws and the surrounding tissues in 365 patients equally divided between men and women. 56.5% of the cases were above the age of 50. In 228 cases there were other metastases as well, whereas in 114 cases the only metastasis found was the one under study. In 22% of the cases, the metastatic focus in our area was the first indication of the existence of an undiagnosed primary malignant tumour somewhere else.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Oral and Maxillofacial Clinic, General Peripheral Hospital of Attica, Kifissia, Athens, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Zachariades
mesh_terms: D001943:Breast Neoplasms; D006801:Humans; D007573:Jaw Neoplasms / Q000556:secondary*; D007680:Kidney Neoplasms; D008175:Lung Neoplasms; D009062:Mouth Neoplasms / Q000556:secondary*; D009382:Neoplasms, Unknown Primary