title: Progress in medical defense against nerve agents.
abstract: For nearly 50 years, nerve agents have constituted a serious threat that has stimulated extensive efforts to develop effective medical countermeasures. Recent progress in producing pharmacologic defenses suggests that humans can be largely protected from the lethal and prolonged incapacitating effects of these compounds on a chemical battlefield. Current research on new approaches to binding and inactivating nerve agents may further decrease their potential as a threat against protected persons.
authors.affiliation: US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Md 21010-5425.
authors.forename: M A
authors.initials: MA
authors.lastname: Dunn
authors.forename: F R
authors.initials: FR
authors.lastname: Sidell
mesh_terms: D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000627:therapeutic use*; D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors / Q000009:adverse effects; D006801:Humans; D009420:Nervous System / Q000187:drug effects*; D010091:Oximes / Q000008:administration & dosage / Q000494:pharmacology*; D011041:Poisoning / Q000188:drug therapy; D011729:Pyridostigmine Bromide / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D010091:Oximes; D001285:Atropine; D011729:Pyridostigmine Bromide