title: Motor and cognitive testing of bone marrow transplant patients after chemoradiotherapy.
abstract: Assessment of cognitive and motor performance of bone marrow transplant patients prior to, during, and following intensive toxic chemoradiotherapy may provide an important adjunct to measures of physiological and medical status. The present study is an attempt to assess whether, as side-effects, these aggressive treatments result in cognitive performance deficits, and if so, whether such changes recover posttreatment. Measurement of cognitive ability in this situation presents special problems not encountered with one-time tests intended for healthy adults. Such tests must be sensitive to changes within a single individual, which emphasizes the crucial importance of high reliability, stability across repeated-measures, and resistance to confounding factors such as motivation and fatigue. The present research makes use of a microbased portable test battery developed to have reliable and sensitive tests which were adapted to study the special requirements of transplant patients who may suffer cognitive deficits as a result of treatment. The results showed slight but significant changes in neuropsychological capacity when compared to baseline levels and controls, particularly near the beginning of treatment. The sensitivity of the battery in detecting such subtle temporary changes is discussed in terms of past research showing effects of other stressors, such as stimulated high altitude and ingestion of alcohol, on these measures.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: P
authors.initials: P
authors.lastname: Parth
authors.forename: W P
authors.initials: WP
authors.lastname: Dunlap
authors.forename: R S
authors.initials: RS
authors.lastname: Kennedy
authors.forename: J M
authors.initials: JM
authors.lastname: Ordy
authors.forename: N E
authors.initials: NE
authors.lastname: Lane
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D001921:Brain / Q000528:radiation effects; D002648:Child; D003072:Cognition Disorders / Q000209:etiology*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007938:Leukemia / Q000601:surgery*; D008297:Male; D019965:Neurocognitive Disorders / Q000209:etiology*; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000209:etiology*; D011596:Psychomotor Disorders / Q000209:etiology*; D011832:Radiation Injuries / Q000209:etiology; D019966:Substance-Related Disorders / Q000209:etiology; D014916:Whole-Body Irradiation
chemical_list: D003520:Cyclophosphamide