[Detection of endotoxin in synovial tissue of patients with inflammatory-rheumatic diseases].
The etiology of inflammatory rheumatic diseases is unknown. The hypothesis, that bacteriae may play a part in the induction of a rheumatic synovialitis is further substantiated by the detection of Endotoxin (Lipid A) in the synovial membranes of five of eleven patients with early synovitis (disease duration shorter than 6 months) by using anti Lipid A monoclonal antibodies. Endotoxin (Lipid A) is a component of gram-negative bacteriae and Chlamydiae. It is a potent immunogen, and could be the link between infection of the gut or the urogenital system and the rheumatic synovialitis.
Wagener
P
P
Medizinische Hochschule Hannover, Zentrum Innere Medizin, Abteilung Rheumatologie.
Hammer
M
M
Schedel
I
I
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D001170:Arthritis, Infectious / Q000473:pathology*; D001172:Arthritis, Rheumatoid / Q000473:pathology*; D001182:Arthroscopy; D001706:Biopsy; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007719:Knee Joint / Q000473:pathology; D008050:Lipid A / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000473:pathology*; D013583:Synovial Membrane / Q000473:pathology; D013585:Synovitis / Q000473:pathology*
D000911:Antibodies, Monoclonal; D008050:Lipid A
Nachweis von Endotoxin im Synovialgewebe von Patienten mit entzündlich-rheumatischen Erkrankungen.