[Treatment of upper genital infections in women. Multicenter study of the comparative efficacy and tolerance of an amoxicillin-clavulanic acid combination and of a triple antibiotic combination].
Eighty-two patients with laparoscopically confirmed salpingitis were randomly divided into two groups in a multicentre and prospective trial. Single drug therapy with the amoxicillin-clavulanic acid combination was used in 42 patients (group A). The other 40 patients were given a combination of penicillin, aminoside and metronidazole (group B). For each case a secondary prescription for a tetracycline was discussed. Clinical results were comparable in both groups: sooner (at the end of the hospitalization period) in group A: 10 cured, 30 improved and 2 failures against 9 cured, 30 improved in group B. Later (evaluation after 5 to 8 weeks) a relapse was noted in five patients in group A and included one case of angioedema in group B. It is concluded that amoxicillin-clavulanic acid combination is a satisfactory alternative to the penicillin-aminoside-metronidazole combination, especially as it is simpler to use.
Buisson
P
P
Hôpital Jean-Verdier, Bondy.
Mulard
C
C
Baudet
J
J
Bernard
P
P
Mares
P
P
Montero
M
M
Lerat
M
M
Quereux
C
C
Santarelli
J
J
Valette
C
C
D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use*; D019980:Amoxicillin-Potassium Clavulanate Combination; D002969:Clavulanic Acids / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010303:Paromomycin / Q000627:therapeutic use*; D010406:Penicillins / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation; D012488:Salpingitis / Q000188:drug therapy*
D002969:Clavulanic Acids; D010406:Penicillins; D008795:Metronidazole; D010303:Paromomycin; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin
Traitement des infections génitales hautes de la femme. Etude multicentrique de l'efficacité et de la tolérance comparées de l'association amoxicilline-acide clavulanique et d'une triple association antibiotique.