[Pharmacologic effects of peripheral vasodilators in patients with secondary pulmonary hypertension].
A single dose of capoten (25 mg) and prazosin (I mg) was given to 82 patients with stable pulmonary hypertension and chronic non-specific pulmonary diseases and to 34 patients with the above condition and arterial hypertension. Systolic and diastolic pressure in the system of the pulmonary artery and total pulmonary and total peripheral resistance were decreased; capoten exhibited more pronounced hypotensive effect. Unidirectional changes were revealed in the course treatment. Combined use of capoten, prazosin and euphilline produced the additional hypotensive effect on pulmonary circulation. Capoten and prazosin had no direct broncholytic effect.
Kukes
V G
VG
Tsoĭ
A N
AN
Abrosimov
A G
AG
Nasyrov
Sh N
ShN
Belov
A M
AM
D000293:Adolescent; D000328:Adult; D000368:Aged; D002216:Captopril / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008173:Lung Diseases, Obstructive / Q000150:complications; D008875:Middle Aged; D011224:Prazosin / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents; D002216:Captopril; D011224:Prazosin
Farmakologicheskie éffekty perifericheskikh vazodilatatorov u bo'lnykh so vtorichnoĭ legochnoĭ gipertenzieĭ.