title: Mapping minor H genes.
abstract: The manner in which minor histocompatibility (H) antigens have been defined in mouse and man, in vivo and in vitro, is considered. Chromosomal mapping of minor H genes using T-cell clones is illustrated, with particular reference to the H-Y antigen gene, using the sex-reversing translocation Sxr of mouse and the Sxr' mutation derived from it. A number of minor H antigen-specific T-cell clones restricted by class I or class II major histocompatibility complex (MHC) molecules are described, together with information about their phenotypes and T-cell receptor usage.
authors.affiliation: MRC Clinical Research Centre, Transplantation Biology Section, Harrow, Middlesex, U.K.
authors.forename: E
authors.initials: E
authors.lastname: Simpson
authors.forename: K
authors.initials: K
authors.lastname: Tomonari
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D006801:Humans; D051379:Mice; D008912:Minor Histocompatibility Loci