Effect of sulindac on angiotensin converting enzyme inhibitor-induced cough: randomised placebo-controlled double-blind cross-over study.
The effect of sulindac on ACE inhibitor-induced cough was studied in eight hypertensive subjects in a randomised placebo-controlled double blind cross-over trial. There was no significant improvement in cough or sense of well-being. Blood pressure, renal function, plasma renin and ACE activity were unchanged. Sulindac however, appears to be effective in some individuals in reducing ACE inhibitor-induced cough with acceptable tolerance and few side effects. Further work is needed to elucidate the mechanism of sulindac's interaction with ACE inhibitors.
Gilchrist
N L
NL
Department of Geriatric Medicine, Princess Margaret Hospital, Christchurch, New Zealand.
Richards
A M
AM
March
R
R
Nicholls
M G
MG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D001794:Blood Pressure; D003371:Cough / Q000139:chemically induced* / Q000188:drug therapy; D004311:Double-Blind Method; D006304:Health Status; D006801:Humans; D008875:Middle Aged; D010919:Placebos; D016032:Randomized Controlled Trials as Topic; D012649:Self Concept; D013467:Sulindac / Q000627:therapeutic use*
D000806:Angiotensin-Converting Enzyme Inhibitors; D010919:Placebos; D013467:Sulindac