title: Human telomeres: fusion and interstitial sites.
abstract: The ends of human chromosomes have been shown recently to resemble those of simple organisms. With this in mind, we discuss the nature and possible significance of rare chromosome fusion events thought to involve telomeres, particularly those fusion events found in some tumours. Also we argue that interstitial telomere-like stretches may be particularly prone to recombination, breakage and fragility.
authors.forename: N D
authors.initials: ND
authors.lastname: Hastie
authors.forename: R C
authors.initials: RC
authors.lastname: Allshire
mesh_terms: D000818:Animals; D002877:Chromosomes, Human; D004261:DNA Replication; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid