Disulfide-linked gamma delta T cell antigen receptors expressed on T cells derived from patients with primary immunodeficiency disorders.
T cell lines or clones from two patients, one with a partial DiGeorge syndrome and one with severe common variable immunodeficiency expressed disulfide-linked gamma delta T cell antigen receptor (TCR) comprised of a gamma-chain polypeptide of 40-43 kD, and a delta-chain polypeptide of 37-40 kD. This gamma delta TCR appears to be similar to that found on T cell clones, and lines derived from peripheral blood lymphocytes from normal donors. Previous studies have shown that T cell lines derived from the peripheral blood of patients with immunodeficiency disorders express non-disulfide-linked gamma delta TCR. In contrast to the latter and coincident with findings in the present study, the vast majority of T cell lines and clones derived from the peripheral blood of normal donors express disulfide-linked gamma delta TCR.
Seki
H
H
Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Nanno
M
M
Day
N K
NK
Good
R A
RA
Platsoucas
C D
CD
D015703:Antigens, CD / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D002478:Cells, Cultured; D004062:DiGeorge Syndrome / Q000276:immunology*; D004220:Disulfides; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007163:Immunosorbent Techniques; D046911:Macromolecular Substances; D008970:Molecular Weight; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D000954:Antigens, Surface; D004220:Disulfides; D046911:Macromolecular Substances; D011948:Receptors, Antigen, T-Cell