Dendritic cells in health and disease.
Cells with a dendritic morphology that are rich in surface class II histocompatibility antigens (Ia antigens) but lacking in other lymphocytes or monocyte markers constitute a small (less than 1%) proportion of circulating mononuclear cells, but in inflammatory joint effusions they comprise up to 7% of the mononuclear population. Their role as accessory cells in normal autologous and allogenic mixed leukocyte reactions is reviewed and the possible contribution of dendritic cells to intra-articular immunologic processes is considered.
Tsai
V
V
Department of Medicine, University of California, San Diego 92103.
Bergroth
V
V
Zvaifler
N J
NJ
D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D002450:Cell Communication; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D013582:Synovial Fluid / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D007375:Interleukin-1