[Isoantigens ABH in bladder tumors as an indicator of malignant potential: a combined study with CEA, BMG, Leu-M1 and H-Ag].
The author performed immunohistochemical staining of blood group antigen (BGA), CEA, BMG, Leu-M1 and H-Ag on 43 patients with primary superficial bladder tumor to evaluate the malignant potential of bladder tumor. There were no obvious relationships among reactivities to BGA, CEA, BMG, Leu-M1 and H-Ag in identical tissue. Although BGA, CEA and Leu-M1 could be used individually as indicators of malignant potential, of the three, BGA was found to be most useful. Concomitant use of Leu-M1 with BGA might compensate for the disadvantages of BGA alone and make prediction of prognosis more objective. Then, a new evaluation criteria for detecting malignant potential of bladder tumor was proposed.
Saegusa
M
M
Department of Urology, Okayama University Medical School.
D000017:ABO Blood-Group System; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000943:Antigens, Differentiation / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000473:pathology*; D001613:beta 2-Microglobulin / Q000032:analysis*
D000017:ABO Blood-Group System; D000943:Antigens, Differentiation; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D001613:beta 2-Microglobulin