[Pharmacologic possibility of limiting the energy-dependent accumulation of calcium by mitochondria of the ischemic myocardium].
In experiments with total ischemia of the isolated rat heart it was found that a preliminary administration of preparations with malonate-like action to the animals exerts, unlike isoptin, cold-like effect on the time-course of calcium levels in mitochondria of the ischemic myocardium and limits the process of accumulation and release of calcium by organelles.
Zamost'ianova
G B
GB
Urakov
A L
AL
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism*; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism; D066298:In Vitro Techniques; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D016293:Moricizine; D010208:Papaverine / Q000031:analogs & derivatives / Q000627:therapeutic use; D010640:Phenothiazines / Q000627:therapeutic use; D051381:Rats; D013696:Temperature; D014665:Vasodilator Agents / Q000627:therapeutic use; D014700:Verapamil / Q000627:therapeutic use
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D014665:Vasodilator Agents; D016293:Moricizine; C005317:drotaverin; D014700:Verapamil; D010208:Papaverine; C046818:ethacizine; D002118:Calcium
Farmakologicheskaia vozmozhnost' ogranicheniia énergozavisimoĭ akkumuliatsii kal'tsiia mitokhondriiami ishemizirovannogo miokarda.