[Halofantrine in the treatment of malaria. Clinical trial in a semi-rural zone of Cameroon].
Twelve children, 2 to 15 years of age, with falciparum malaria (parasitaemia 4,500 to 170,000/mm3) have taken 24 mg/kg body weight of halofantrine hydrochloride (Halfan) per os in three divided doses given within 12 hours. The symptomatology improved after 24 to 48 hours, with no more fever 5 to 90 hours after treatment and with a decrease of splenomegaly in 80% of the cases. The parasitic clearance was obtained after 24 to 60 hours. The haematocrit started raising again in 58% of the cases. Halofantrine hydrochloride is an efficient antimalarial drug in semi-immune patients. It is well tolerated and well accepted, thus representing an alternative for the cure of chloroquine-resistant falciparum malaria.
Raccurt
C P
CP
Service de Parasitologie de l'Université de Bordeaux, France.
Ribou
G
G
Lambert
M T
MT
Bouloumie
J
J
Macaigne
F
F
Ripert
C
C
D000293:Adolescent; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D002163:Cameroon; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D010616:Phenanthrenes / Q000009:adverse effects / Q000627:therapeutic use*; D010963:Plasmodium falciparum / Q000302:isolation & purification; D012424:Rural Population
D000962:Antimalarials; D010616:Phenanthrenes; C023768:halofantrine
L'halofantrine dans le traitement du paludisme. Essai clinique en zone semi-rurale au Cameroun.