[Effect of recombinant human alpha-interferon (reaferon) on macrophage functional activity in mice].
The influence of human recombinant alpha 2-interferon (reaferon) on the parameters of the phagocytic activity of mouse peritoneal macrophages (migration, spreading, adhesion and absorption of corpuscular antigen) has been studied. Reaferon in doses of 5-5 X 10(2) I. U./ml has been found to produce a stimulating effect on all parameters under study. The data obtained in this study suggest that a stimulating effect on the functional activity of macrophages is the same for recombinant (alpha 2) interferon and natural alpha-interferon.
Vasilenko
R N
RN
Denisov
L A
LA
Galaktionov
V G
VG
D000042:Absorption; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects / Q000276:immunology; D002465:Cell Movement / Q000187:drug effects / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D008262:Macrophage Activation / Q000187:drug effects* / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D011994:Recombinant Proteins; D012486:Salmonella typhimurium
D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins
Vliianie rekombinantnogo al'fa-interferona cheloveka (reaferona) na funktsional'nuiu aktivnost' makrofagov mysheĭ.