title: Granulomatous eruption after BCG vaccine immunotherapy for malignant melanoma.
abstract: In a patient receiving intralesional bacille Calmette-Guérin vaccine injections for recurrent cutaneous metastases of malignant melanoma of the right leg, a striking eruption developed on that limb only. The eruption consisted of multiple 1 to 2 mm, reddish brown, flat-topped papules, with confluence into plaques. Histopathologic examination showed multiple tuberculoid granulomas within the papillary and reticular dermis; special stains and cultures were negative for mycobacteria.
authors.affiliation: Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston 02114.
authors.forename: C R
authors.initials: CR
authors.lastname: Shea
authors.forename: M J
authors.initials: MJ
authors.lastname: Imber
authors.forename: T G
authors.initials: TG
authors.lastname: Cropley
authors.forename: A B
authors.initials: AB
authors.lastname: Cosimi
authors.forename: A J
authors.initials: AJ
authors.lastname: Sober
mesh_terms: D001500:BCG Vaccine / Q000009:adverse effects*; D005260:Female; D006099:Granuloma / Q000209:etiology*; D006801:Humans; D007868:Leg Dermatoses / Q000209:etiology*; D008545:Melanoma / Q000628:therapy*; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000209:etiology*; D009165:Mycobacterium Infections, Nontuberculous / Q000209:etiology*; D012878:Skin Neoplasms / Q000628:therapy*
chemical_list: D001500:BCG Vaccine