title: [Magnesium--a new therapeutic alternative in primary dysmenorrhea].
abstract: 50 patients suffering from primary dysmenorrhoea were treated with Magnesium (Mg 5-longoral, Artesan GmbH) in a double-blind study. After a six-month period 21 out of 25 women showed a decline of symptoms, only 4 ones reported no therapeutical effect. For monitoring treatment results prostaglandin F2 alpha (PGF2 alpha) was measured every second month. On Mg-therapy conditions we achieved a reduction of PGF2 alpha in menstrual blood to 45% of value before treatment started. As against that 90% of basic concentration were estimated from women who received a placebo. Probably, the specific therapeutical effect of Mg based on inhibition of biosynthesis of PGF2 alpha but also on its direct muscle relaxant and vasodilatory effect. Beside the PG-synthesis and ovulation inhibitors the use of Magnesium is a potential, natural opportunity to treat primary dysmenorrhoea, which is widely free of side effects.
authors.affiliation: Klinik für Gynäkologie und Geburtshilfe, Medizinischen Akademie Magdeburg.
authors.forename: B
authors.initials: B
authors.lastname: Seifert
authors.forename: P
authors.initials: P
authors.lastname: Wagler
authors.forename: S
authors.initials: S
authors.lastname: Dartsch
authors.forename: U
authors.initials: U
authors.lastname: Schmidt
authors.forename: J
authors.initials: J
authors.lastname: Nieder
mesh_terms: D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D015237:Dinoprost / Q000097:blood; D004311:Double-Blind Method; D004412:Dysmenorrhea / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use*
chemical_list: D001224:Aspartic Acid; D015237:Dinoprost; D008274:Magnesium
vernacular_title: Magnesium--eine therapeutische Alternative bei der primären Dysmenorrhoe.