Amyloid plaques, neurofibrillary tangles and their relevance for the study of Alzheimer's disease.
The relevance of plaques and tangles to the study of Alzheimer's disease is considered. Recent results concerning isoforms of microtubule-associated protein tau, their expression and incorporation into paired helical filaments, are discussed.
Goedert
M
M
Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.
Crowther
R A
RA
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000682:Amyloid / Q000378:metabolism*; D016229:Amyloid beta-Peptides; D006801:Humans; D009454:Neurofibrils / Q000378:metabolism* / Q000473:pathology
D000682:Amyloid; D016229:Amyloid beta-Peptides