[Immuno-allergic thrombopenias and leukopenias induced by drugs].
Certain types of cytopenia are due to the destruction of blood cells by an antibody, active only in conjunction with a drug which has previously provoked sensitivity in patients when administered in standard doses. Drug-induced thrombocytopenia and leucopenia of allergic origin are relatively rare. They produce characteristic symptoms, i.e. brutal onset and acute development of the disease; healing takes place when the drug in question is withdrawn. Haematological diseases of drug-related aetiology are being brought to light by serological methods which detect the specific antibody for the drug responsible for the accident. The physiopathological mechanism is still not clearly elucidated.
Marcelli-Barge
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Labortoire d'Immunologie et d'Histocompatibilité, Hôpital Saint-Louis, Paris.
D004342:Drug Hypersensitivity; D064420:Drug-Related Side Effects and Adverse Reactions; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology; D011696:Purpura, Thrombocytopenic / Q000139:chemically induced; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology
D006493:Heparin
Thrombopénies et leucopénies immuno-allergiques d'origine médicamenteuse.