Vesicular pemphigoid--ultrastructural and immunoelectron microscopic study.
We report a patient with vesicular pemphigoid who showed clinically numerous small vesicles and figurate erythema over the trunk and extremities. Although large blisters were absent, immunofluorescent study revealed IgG and C3 deposition at the basement membrane zone of the lesional skin. The patient responded well to the combined use of corticosteroid and dapsone. Immunoelectron microscopy showed IgG and C3 deposition at the undersurface membrane of the basal cells and the lamina lucida. Electron microscopy of the nonvesiculated early erythematous skin showed small vacuoles and lacunae along the uppermost portion of the dermis. Although the clinical features of this patient and the good therapeutic response to dapsone were atypical, the results of immunopathology and immunoelectron microscopy were consistent with typical pemphigoid.
Hayakawa
K
K
Department of Dermatology, Keio University, School of Medicine, Tokyo, Japan.
Shimizu
H
H
Amagai
M
M
Harada
T
T
Nishikawa
T
T
Yamasaki
Y
Y
D000368:Aged; D001485:Basement Membrane / Q000032:analysis / Q000276:immunology; D003176:Complement C3 / Q000032:analysis; D003622:Dapsone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008854:Microscopy, Electron; D010391:Pemphigoid, Bullous / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use; D012872:Skin Diseases, Vesiculobullous / Q000473:pathology*
D003176:Complement C3; D007074:Immunoglobulin G; D003622:Dapsone; D011239:Prednisolone