title: Potential of wide bore open tubular columns in gas chromatographic analysis of drugs.
abstract: The recent introduction of wide bore flexible fused silica columns and the development of chemically bonded stationary phases for gas chromatography (GC) has opened up new possibilities for carrying out medium resolution capillary GC on packed column instruments. The favourable chromatographic properties of wide bore capillary columns make them ideal for applications in many areas of GC. This review discusses the characteristics of more popular 0.53 mm I.D. wide bore columns, experimental conditions necessary for their use and their applications in the pharmaceutical field with an emphasis on the analysis of drugs in biological fluids.
authors.affiliation: Department of Pharmacy, General Infirmary, Leeds, Yorkshire, U.K.
authors.forename: A C
authors.initials: AC
authors.lastname: Mehta
mesh_terms: D002849:Chromatography, Gas / Q000295:instrumentation*; D004364:Pharmaceutical Preparations / Q000032:analysis*
chemical_list: D004364:Pharmaceutical Preparations