title: [Total intravenous anesthesia in direct laryngoscopy. A comparison of methohexital (Brietal) and thiopental].
abstract: A material of 36 patients to be submitted to direct laryngoscopy was subdivided at random in a double blind investigation to total intravenous anaesthesia with metohexitone or thiopentone. Alfentanil was employed as an analgesic and relaxation was obtained with vecuronium. The anaesthesia was maintained with continuous barbiturate infusion and supplementary alfentanil and vecuronium. The patients in the metohexitone group showed significantly faster recovery with an average of seven minutes as compared with 20 minutes in the thiopentone group and significantly more had Glasgow coma scores of over 12 after 30 minutes. After 60 and 90 minutes, no significant differences could be demonstrated between the groups. It is concluded that thiopentone is unsuitable for total intravenous anaesthesia for direct laryngoscopy whereas metohexitone was particularly suitable. Metohexitone is proposed as an alternative to the more recent and more expensive propofol. The frequency of pain on injection of metohexitone does not differ from that with propofol and this may be reduced by employing a vein in the cubital fossa instead of a vein on the dorsum of the hand.
authors.forename: H
authors.initials: H
authors.lastname: Schou
authors.forename: O B
authors.initials: OB
authors.lastname: Olsen
authors.forename: L
authors.initials: L
authors.lastname: Kjeldsen
mesh_terms: D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D007828:Laryngoscopy; D008723:Methohexital; D008875:Middle Aged; D011897:Random Allocation; D013874:Thiopental
chemical_list: D008723:Methohexital; D013874:Thiopental
vernacular_title: Total intravenøs anaestesi til direkte laryngoskopi. En sammenligning mellem metohexital (Brietal) og tiopental.