[A study of the proliferative activity of DNA polymerase alpha immunoreactivity in breast cancer].
DNA polymerase alpha activity is associated with cell proliferation, independently of the cell cycle phase, and a simple and reproducible method for the immunohistochemical demonstration of DNA polymerase alpha has been developed. In an analysis of a total of 76 human breast cancer tissues using this procedure, the clinico-pathological findings revealed that only the estrogen receptor (ER) significantly correlated with the DNA polymerase alpha activity. Therefore, this suggests that ER-negative tumors had a higher proliferative activity.
Nishimura
R
R
Dept. of Surgery, Kumamoto Municipal Hospital.
Nagao
K
K
Matsuda
M
M
Baba
K
K
Matsuoka
Y
Y
Ueno
Y
Y
Morinaga
H
H
Nagase
H
H
Miyayama
O
O
Hamada
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000032:analysis / Q000201:enzymology* / Q000473:pathology; D002455:Cell Division; D004257:DNA Polymerase II / Q000032:analysis / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis
D014408:Biomarkers, Tumor; D011960:Receptors, Estrogen; D004257:DNA Polymerase II