title: [The PM-Scl (polymyositis-scleroderma) autoantibody and its nucleolar fluorescence pattern].
abstract: By indirect immunofluorescence studies of antinuclear antibodies on hamster liver imprints as a substrate performed to determine the nuclear staining pattern of sera from patients with connective tissue diseases 10 sera showed a distinct homogeneous nucleolar staining pattern associated with weaker speckled or homogeneous nucleoplasmic fluorescence. In all 10 cases the antibodies revealed the PM-Scl specificity in immunodiffusion. Clinically 9 patients had an acrosclerosis, in 56% overlapped with symptoms of polymyositis. Only one patient had a diffuse scleroderma. The homogeneous nucleolar immunofluorescence pattern of PM-Scl should be distinguished from mixed nucleolar and diffuse reticular nucleoplasmic pattern of Scl-70.
authors.forename: G
authors.initials: G
authors.lastname: Kühn
authors.forename: M
authors.initials: M
authors.lastname: Jarzabek-Chorzelska
authors.forename: M
authors.initials: M
authors.lastname: Blaszczyk
authors.forename: Z
authors.initials: Z
authors.lastname: Kolacinska-Strasz
authors.forename: T P
authors.initials: TP
authors.lastname: Chorzelski
authors.forename: S
authors.initials: S
authors.lastname: Jablonska
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis*; D002466:Cell Nucleolus / Q000648:ultrastructure*; D004264:DNA Topoisomerases, Type I; D005455:Fluorescent Antibody Technique; D006801:Humans; D009220:Myositis / Q000473:pathology*; D009687:Nuclear Proteins / Q000276:immunology*; D012595:Scleroderma, Systemic / Q000473:pathology*
chemical_list: D000974:Antibodies, Antinuclear; D009687:Nuclear Proteins; C048100:Scl 70 antigen, human; D004264:DNA Topoisomerases, Type I
vernacular_title: Der PM-Scl- (Polymyositis-Sklerodermie-) Autoantikörper und sein nukleoläres Fluoreszenzmuster.