Thyroiditis as a model of organ specific autoimmune disease.
In the last few years a great deal of information on the etiopathogenetic aspects of organ-specific autoimmune diseases has been obtained from the extensive study of both animal models of experimental or spontaneous thyroiditis and of human thyroid autoimmune diseases. It has been clearly shown that genetic factors play a fundamental etiologic role. They are responsible for the dysregulation of the immune system and for the target organ susceptibility which favor the onset of the disease. Environmental factors are presumed to act as initiating or precipitating events, leading genetically predisposed individuals to thyroid autoimmunity. A number of immune mechanisms able to trigger autoimmune responses, such as antigenic cross-reactions and the aberrant expression of HLA class II molecules, have been suggested, but the definition of why and how they become operative requires further investigation. Data obtained from experimental models and from human thyroid diseases clearly indicate that the ongoing expansion of autoreactive T cells with specificity for thyroid autoantigens represents the main immunological event responsible for induction and maintenance of thyroid damage. Such autoreactive T cells can induce tissue lesions through activation of different effector systems and secretion of different combinations of lymphokines. In overt thyroid autoimmune diseases autoantibodies directed against functional molecules or cellular receptors can also be involved in the pathogenesis of tissue lesions. However, the pathogenesis of inflammatory destructive lesions of the thyroid is more complex and not yet fully elucidated. It is worthy of note that a large proportion of T cells present in inflammatory human thyroid infiltrates are apparently not directed against the thyroid autoantigens recognized so far.(ABSTRACT TRUNCATED AT 250 WORDS)
Del Prete
G F
GF
Allergology and Clinical Immunology, University of Florence, Italy.
Tiri
A
A
Mariotti
S
S
Parronchi
P
P
Pinchera
A
A
Romagnani
S
S
Ricci
M
M
D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology; D003602:Cytotoxicity, Immunologic; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008222:Lymphokines / Q000096:biosynthesis; D008954:Models, Biological; D009928:Organ Specificity; D013967:Thyroiditis, Autoimmune / Q000209:etiology*
D008222:Lymphokines