title: Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine.
abstract: Tests have been carried out with several plant flavonoids to detect their ability to suppress mutagenesis in Salmonella typhimurium strain TA100 NR induced by the direct-acting carcinogen N-methyl-N'-nitro-N-nitrosoguanidine. Among the most effective flavonoids are the isoflavone, biochanin A, the flavanone glycoside, naringin, and its aglycone, naringenin, and several flavonols, e.g. morin, fisetin, kaempferol, gossypetin and quercetin, including a flavonol glycoside, rutin. In particular, naringin possesses exceptional antimutagenic activity, in as much as, less than half the equimolar amount can reduce the mutagenic potency of this carcinogen by 50%. These flavonoids appear to act either by preventing passage of the carcinogen into bacterial cells or by altering some cellular processes.
authors.affiliation: Biochemistry Division, Bhabha Atomic Research Centre, Bombay India.
authors.forename: A R
authors.initials: AR
authors.lastname: Francis
authors.forename: T K
authors.initials: TK
authors.lastname: Shetty
authors.forename: R K
authors.initials: RK
authors.lastname: Bhattacharya
mesh_terms: D005419:Flavonoids / Q000494:pharmacology*; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009154:Mutation; D010944:Plants; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D005419:Flavonoids; D008769:Methylnitronitrosoguanidine