[Study of immunoregulating properties of an interferon inducer in animals with various reactions to the antigen].
Influence of dsRNA isolated from killer yeast of S. cerevisiae on humoral and cellular immune responses in mice CBA/CaY and C57Bl/6Y with opposing reaction to the antigen was studied. It was shown that after administration of the yeast dsRNA preparation to the animals simultaneously with the antigen there was an increase in the number of the antibody forming cells in the spleen and the titer of hemolytic antibodies in blood serum of the animals with high and low reactions to the antigen. After sensitization with different doses of sheep red blood cells (10(7) and 10(8)) the preparation had immunomodulating action on development of DTH in mice CBA/CaY. The effect of the dsRNA preparation on the immunity system depended on the preparation dose, antigen loading and animal genotype and was the most marked in mice CBA/CaY with interferon levels in blood serum 2-3 times higher than those in mice C57Bl/6Y.
Sysoeva
G M
GM
Razvorotnev
V A
VA
Fadina
V A
VA
Kostomakha
A N
AN
D000276:Adjuvants, Immunologic; D000818:Animals; D000921:Antibody-Producing Cells / Q000166:cytology; D000941:Antigens / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D007114:Immunization; D007369:Interferon Inducers / Q000276:immunology / Q000494:pharmacology*; D007370:Interferon Type I / Q000096:biosynthesis*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012330:RNA, Double-Stranded / Q000276:immunology / Q000494:pharmacology*; D012331:RNA, Fungal / Q000276:immunology / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae; D012756:Sheep; D013154:Spleen / Q000166:cytology
D000276:Adjuvants, Immunologic; D000941:Antigens; D007369:Interferon Inducers; D007370:Interferon Type I; D012330:RNA, Double-Stranded; D012331:RNA, Fungal
Issledovanie immunoreguliatornykh svoĭstv induktora interferona u oppozitnoreagiruiushchikh na antigen zhivotnykh.