[Design and synthesis of LHRH analogs].
In the hope to find new superagonists of LHRH, here we report the synthesis of six analogs by changing residue 5 of [D-Trp6 (or D-Arg6), des-Gly10]-LHRH-EA. For the convenience of comparison, the known compound [D-Trp6, desGly10]-LHRH-EA was also synthesized.
Chu
J Y
JY
Ding
J F
JF
Liu
Y Z
YZ
Zhu
B T
BT
Chu
Y H
YH
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008184:Luteal Cells / Q000187:drug effects; D011374:Progesterone / Q000378:metabolism; D051381:Rats
D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone