title: Treatment of hemoptysis patients by thrombin and fibrinogen-thrombin infusion therapy using a fiberoptic bronchoscope.
abstract: We report the results of a simplified fiberoptic bronchoscopy-based procedure for thrombin and fibrinogen-thrombin infusion therapy in hemoptysis patients. A total of 33 patients with frequent bloody sputum or hemoptysis received either thrombin (19 cases) or fibrinogen-thrombin (14 cases) infusion therapy. Massive hemoptysis was present in ten patients receiving thrombin therapy and nine patients receiving fibrinogen-thrombin therapy. Thrombin therapy was very effective in 14 cases, effective in one case and ineffective in four cases. Fibrinogen-thrombin therapy was very effective in 11 cases and somewhat effective in three cases; two of these three patients had tuberculosis and the third required emergency surgery for removal of a foreign object in the bronchus. We conclude that infusion therapy using a fiberoptic bronchoscope is a simple and effective low-risk technique of choice for the treatment of hemoptysis patients.
authors.affiliation: Department of Internal Medicine, Yamagata Prefectural Central Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D020680:Bronchoscopes; D005336:Fiber Optic Technology / Q000295:instrumentation; D005340:Fibrinogen / Q000008:administration & dosage* / Q000627:therapeutic use; D006469:Hemoptysis / Q000188:drug therapy*; D006489:Hemostatic Techniques; D006801:Humans; D007263:Infusions, Parenteral; D013917:Thrombin / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D005340:Fibrinogen; D013917:Thrombin