title: Efficacy of sulbactam/cefoperazone for the treatment of infections in patients with hematologic diseases.
abstract: The efficacy and safety of sulbactam/cefoperazone (SBT/CPZ) was studied in 94 patients with severe infections and concomitant hematologic diseases. All of the study patients were included in the evaluation for safety, and 76 cases were evaluable for efficacy. Clinical efficacy was excellent in 13 cases (17.1%), good in 27 cases (35.5%), fair in seven cases (9.2%), and poor in 29 cases (38.2%). The bacteriologic eradication was 66.7% for Gram-negative bacilli and 50.0% for Gram-positive bacteria. The efficacy rate for neutropenic patients with counts less than 50 mm3 and 100 mm3 were 47.5 and 42.9%, respectively. Efficacy in patients for whom other antibiotic therapy before treatment with SBT/CPZ had been ineffective was 46.2%. Side effects were reported in one case (1.1%), and abnormal serum liver tests in five cases (5.3%); both returned to normal after discontinuation of the study medication. SBT/CPZ was an effective antibiotic for the treatment of severe infections in the presence of concurrent hematologic diseases.
authors.affiliation: Hanshin Study Group of Hematopoietic Disorders and Infections, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Horiuchi
authors.forename: H
authors.initials: H
authors.lastname: Hasegawa
authors.forename: T
authors.initials: T
authors.lastname: Kageyama
authors.forename: T
authors.initials: T
authors.lastname: Yonezawa
authors.forename: T
authors.initials: T
authors.lastname: Kitani
authors.forename: T
authors.initials: T
authors.lastname: Masaoka
authors.forename: K
authors.initials: K
authors.lastname: Yasunaga
authors.forename: H
authors.initials: H
authors.lastname: Kawagoe
authors.forename: K
authors.initials: K
authors.lastname: Nagai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy*; D002438:Cefoperazone / Q000008:administration & dosage*; D002648:Child; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005260:Female; D006090:Gram-Negative Bacteria; D006094:Gram-Positive Bacteria; D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D013407:Sulbactam / Q000008:administration & dosage*
chemical_list: D002438:Cefoperazone; D013407:Sulbactam