title: [A case of pneumonitis due to serrapeptase].
abstract: A case of pneumonitis due to Serrapeptase was described. A 69-year-old man was treated with Serrapeptase for 16 days because of common cold, then fever, nonproductive cough and dyspnea developed and chest X-ray revealed diffuse fine granular shadows in bilateral lung fields. Once the administration of Serrapeptase was halted, symptoms, chest X-ray abnormalities and laboratory data improved markedly. The fraction of lymphocytes increased in bronchoalveolar lavage fluid and OKT4/T8 decreased. Microscopic examination of transbronchial lung biopsy showed interstitial pneumonia. Both leukocyte migration inhibition test and sensitized hemagglutination test were positive for Serrapeptase. Based on these findings, we diagnosed this case as Serrapeptase-induced pneumonitis.
authors.forename: K
authors.initials: K
authors.lastname: Hirahara
authors.forename: T
authors.initials: T
authors.lastname: Saitoh
authors.forename: I
authors.initials: I
authors.lastname: Terada
authors.forename: K
authors.initials: K
authors.lastname: Uno
authors.forename: A
authors.initials: A
authors.lastname: Nagai
authors.forename: S
authors.initials: S
authors.lastname: Kioi
authors.forename: M
authors.initials: M
authors.lastname: Arakawa
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002464:Cell Migration Inhibition; D006386:Hemagglutination Tests; D006801:Humans; D008297:Male; D010447:Peptide Hydrolases / Q000009:adverse effects*; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010447:Peptide Hydrolases; C022640:serratiopeptidase