title: Reactivity of CO17-1A and B72.3 in benign and malignant pancreatic diseases.
abstract: The immunoreactivity of two monoclonal antibodies, CO17-1A (recognizing 17-1A antigen) and B72.3 (recognizing TAG-72), was examined in pancreatic tissues from individuals without pancreatic disease and from those with benign and malignant pancreatic disease. 17-1A antigen was found in all cells in the normal tissue, whereas TAG-72 was present in the duct cells in only one case. Both antigens were present in benign diseases; however, in some cells and in some conditions, TAG-72 was significantly less common (P less than .01 to .001) than 17-1A antigen. In pancreatic cancer, 17-1A antigen was present in 87% of cases and TAG-72 antigen was present in 92% of cases. The results indicate that B72.3 is more specific to pancreatic cancer than C017-1A.
authors.affiliation: The Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha 68105.
authors.forename: Y
authors.initials: Y
authors.lastname: Takiyama
authors.forename: M A
authors.initials: MA
authors.lastname: Tempero
authors.forename: H
authors.initials: H
authors.lastname: Takasaki
authors.forename: M
authors.initials: M
authors.lastname: Onda
authors.forename: R
authors.initials: R
authors.lastname: Tsuchiya
authors.forename: M
authors.initials: M
authors.lastname: Büchler
authors.forename: M
authors.initials: M
authors.lastname: Ness
authors.forename: D
authors.initials: D
authors.lastname: Colcher
authors.forename: J
authors.initials: J
authors.lastname: Schlom
authors.forename: P M
authors.initials: PM
authors.lastname: Pour
mesh_terms: D000208:Acute Disease; D000230:Adenocarcinoma / Q000032:analysis / Q000473:pathology*; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002908:Chronic Disease; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D010179:Pancreas / Q000032:analysis / Q000166:cytology* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000032:analysis / Q000473:pathology*; D010195:Pancreatitis / Q000473:pathology*; D012016:Reference Values
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006023:Glycoproteins; C050928:carcinoma-associated antigen 17-1A; C047052:tumor-associated antigen 72