title: Altered gene expression in Alzheimer's disease brain tissue.
abstract: We review the evidence for altered gene expression in Alzheimer's disease brain and identify alternative molecular approaches for isolating additional novel markers. One marker, pADHC-9, was isolated from a human hippocampal cDNA library by differential screening with AD and control cDNA probes. This clone hybridizes to a 2 Kb RNA which is increased 2 fold in AD hippocampus. The deduced amino acid sequence of pADHC-9 codes for a 52 kDAL protein similar to a testicular sulfated glycoprotein secreted by rat Sertoli cells. The normal function of this protein in brain and whether that function is altered in Alzheimer's disease is unknown.
authors.affiliation: Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191.
authors.forename: P C
authors.initials: PC
authors.lastname: May
authors.forename: S A
authors.initials: SA
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: Poirier
authors.forename: M
authors.initials: M
authors.lastname: Lampert-Etchells
authors.forename: C E
authors.initials: CE
authors.lastname: Finch
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism; D000941:Antigens / Q000235:genetics* / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D005786:Gene Expression Regulation; D006023:Glycoproteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans
chemical_list: C056167:Alzheimer's disease antigen; D000941:Antigens; D006023:Glycoproteins