Excitotoxin-induced myocardial necrosis.
The excitotoxins, kainic acid and N-methyl-D-aspartic acid (NMDA), were injected bilaterally into the paraventricular hypothalamus of rats. Kainic acid elicited pressor responses, tachycardia and sudden cardiac death in Nembutal-anesthetized rats. Injections of NMDA caused cardiovascular stimulation on cessation of halothane anesthesia. Intramyocardial hemorrhage, hyaline myocardial necrosis and predominantly mononuclear inflammation were evident 48 h following NMDA. Labetalol pretreatment did not protect from nor did i.v. NMDA cause these changes. Intrahypothalamic excitotoxin injections cause deleterious myocardial changes.
Rockhold
R W
RW
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216.
Acuff
C G
CG
Clower
B R
BR
D000818:Animals; D001224:Aspartic Acid / Q000008:administration & dosage / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000473:pathology; D006339:Heart Rate / Q000187:drug effects; D007033:Hypothalamus, Middle; D007267:Injections; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D009206:Myocardium / Q000473:pathology*; D016202:N-Methylaspartate; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains
D001224:Aspartic Acid; D016202:N-Methylaspartate; D007608:Kainic Acid