Review of dose-response studies of NSAIDs in rheumatoid arthritis.
Double-blind dose-response studies of aspirin, phenylbutazone, indomethacin, ibuprofen, naproxen, piroxicam, diclofenac, diflunisal, and tolfenamic acid were reviewed, using pain and a combined effect measure as outcome variables. The increase in effect obtained with the highest doses of the drugs was small, and as a general rule, NSAIDs should be used at the lower end of the recommended dose ranges.
Gøtzsche
P C
PC
Liver Unit, Hvidovre Hospital, Copenhagen.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010147:Pain Measurement
D000894:Anti-Inflammatory Agents, Non-Steroidal