Effects of the renin inhibitor H77 on angiotensin II, arterial pressure and cardiac function in conscious dogs: comparison with captopril.
The renin inhibitor H77 and the angiotensin I converting enzyme (ACE) inhibitor captopril were compared in separate experiments with infusion of 5% dextrose as a control for the effects on plasma angiotensin II (Ang II) concentration, arterial pressure and cardiac function, measured by Swan-Ganz catheter, in conscious dogs. The effects of a high dose of H77 (10 mg/kg per h) were similar to those of high-dose captopril (6 mg/kg per h). Both reduced plasma Ang II concentration, systemic vascular resistance and arterial pressure; both increased the heart rate; both increased cardiac output but the change was significant only with captopril; neither affected stroke volume, pulmonary artery pressure or pulmonary vascular resistance; both reduced left and right atrial pressures. The similar pattern of effects for the two inhibitors suggests that the mechanism by which they act is the same--reduction in Ang II--and that the cardiovascular effects of H77 are not a specific action of the peptide that is unrelated to the reduction in plasma Ang II concentrations.
Tree
M
M
MRC Blood Pressure Unit, Western Infirmary, Glasgow, UK.
MacArthur
K
K
Inglis
G
G
Leckie
B
B
Lever
A F
AF
Morton
J J
JJ
Szelke
M
M
D000804:Angiotensin II / Q000097:blood*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D012964:Sodium / Q000172:deficiency; D014655:Vascular Resistance / Q000187:drug effects; D000092502:Renin Inhibitors
D000804:Angiotensin II; D002216:Captopril; D009842:Oligopeptides; D012964:Sodium; D000092502:Renin Inhibitors; C034503:H 77