Acceleration of growth in Turner syndrome patients treated with growth hormone: summary of three-year results.
In 1983, a multicenter, collaborative, prospective study was begun to investigate the efficacy of human growth hormone (hGH), alone and in combination with oxandrolone, in girls with Turner syndrome. While subjects in the control group grew 3.8 cm/yr (-0.1 SD for untreated Turner patients), subjects receiving hGH alone grew 6.6, 5.4 and 4.6 cm/yr in years 1-3, respectively (+3.1, +2.0, +1.4 SD). Subjects in the combination therapy group grew 9.8, 7.4 and 6.1 cm/yr (+6.6, +4.3, +3.0 SD). Turner subjects in both treatment groups showed increased in Bayley-Pinneau predicted adult heights and in Turner projected adult heights.
Rosenfeld
R G
RG
Department of Pediatrics, Stanford University School of Medicine, CA 94305.
D001827:Body Height / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D005260:Female; D006128:Growth / Q000187:drug effects*; D013006:Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D015201:Meta-Analysis as Topic; D010074:Oxandrolone / Q000494:pharmacology / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D014424:Turner Syndrome / Q000188:drug therapy* / Q000503:physiopathology
D004338:Drug Combinations; D010074:Oxandrolone; D013006:Growth Hormone