title: Protein translocation and turnover in eukaryotic cells.
abstract: Although most eukaryotic proteins are synthesized in the cytoplasm from mRNAs originating in the nucleus, many function in specialized compartments and must be specifically translocated co- or post-translationally. A variety of signals contained within the amino acid sequence guide these processes as well as direct turnover by different proteolytic schemes. Several properties of the mature protein are determined as a result of translocation and can serve as predictors of cellular localization.
authors.forename: R A
authors.initials: RA
authors.lastname: Bradshaw
mesh_terms: D001692:Biological Transport; D005057:Eukaryotic Cells / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*
chemical_list: D011506:Proteins