title: Adverse effects of amiodarone. Pathogenesis, incidence and management.
abstract: Amiodarone is an extremely effective antiarrhythmic agent for the treatment of both life-threatening ventricular arrhythmias and refractory supraventricular tachyarrhythmias. Subjective minor side effects are common with amiodarone but rarely require discontinuation of therapy and are often handled by dose reduction. Serious end-organ toxicity, including pulmonary fibrosis and drug-induced hepatitis, have been the most common indications for discontinuing amiodarone therapy in these patients.
authors.affiliation: Division of Cardiology, University of Texas Medical School, Houston.
authors.forename: G V
authors.initials: GV
authors.lastname: Naccarelli
authors.forename: R L
authors.initials: RL
authors.lastname: Rinkenberger
authors.forename: A H
authors.initials: AH
authors.lastname: Dougherty
authors.forename: D M
authors.initials: DM
authors.lastname: Fitzgerald
mesh_terms: D000638:Amiodarone / Q000009:adverse effects* / Q000633:toxicity; D000818:Animals; D005260:Female; D006801:Humans; D011247:Pregnancy; D013723:Teratogens
chemical_list: D013723:Teratogens; D000638:Amiodarone