Albumin microspheres. II: Applications in drug delivery.
Albumin microspheres are colloidal particles which are known to sustain the release of entrapped therapeutic agent(s). The rate at which these particles metabolise in vivo can be manoeuvred by varying their synthetic conditions. These particles alter the in vivo distribution of included drugs and hence this carrier has been extensively investigated for drug delivery and targeting in laboratory animals. Attempts have also been made to use this carrier for the delivery of anti-cancer agents in patients with liver cancer. This review is focused on the experimental and clinical applications of albumin microspheres in drug delivery. An account of the toxicological properties of these particles is also presented.
Gupta
P K
PK
Department of Pharmacy, University of Otago Dunedin, New Zealand.
Hung
C T
CT
D000418:Albumins; D000818:Animals; D002214:Capsules / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D004333:Drug Administration Routes; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy; D051379:Mice; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011817:Rabbits; D051381:Rats; D014018:Tissue Distribution
D000418:Albumins; D002214:Capsules; D004364:Pharmaceutical Preparations