Nucleotide sequence of an OXA-2 beta-lactamase gene from the R-plasmid R1767 derived plasmid pBP11 and comparison to closely related resistance determinants found in R46 and Tn2603.
Plasmid pBP11 contains a sequence homologous to Tn21-like element Tn2410 encoding dihydropteroate synthetase and beta-lactamase OXA-2. The nucleotide sequence of a 1.5 kb segment of this region has been determined including the bla gene. It reveals strong sequence homology with the OXA-2 operon of plasmid R46. The implications of an additional 319 bp segment in pBP11 for the different evolution of R46/pKM101 and pBP11 are discussed.
Nücken
E J
EJ
Institut für Bodenbiologie, Bundesforschungsanstalt für Landwirtschaft, FRG.
Henschke
R B
RB
Schmidt
F R
FR
D001483:Base Sequence; D004269:DNA, Bacterial / Q000032:analysis; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D010403:Penicillin Resistance / Q000235:genetics*; D011815:R Factors / Q000235:genetics*; D012486:Salmonella typhimurium / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics*
D004269:DNA, Bacterial; C039404:beta-lactamase OXA-2; D001618:beta-Lactamases