[Effect of obzidan on hemodynamic indices and the renin and aldosterone levels of the blood plasma in patients with juvenile hypertension].
Hemodynamic and humoral indices were studied in patients with juvenile hypertension before and after a months treatment course with obsidan. The beginning of the disease was in 18% distinguished by an increased thickness of the wall and interventricular septum. Obsidan treatment (0.5 mg/kg of body weight) resulted already during the first 2-4 weeks and then on the 3 and 6 month in an improvement of the general condition, normalization of the systolic pressure, cessation of tachycardia, reduction of the elevated cardiac index, reduction of the rate of circular shortening of the myocardial fibers, plasma renin activity and amount of blood aldosterone. Resistance to the effect of obsidan was noted in 10.5%. Some patients showed side-effects.
Zanozdra
N S
NS
Chernoguz
L S
LS
Kupchinskaia
S G
SG
Primak
G F
GF
Korchinskaia
O I
OI
D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood*; D004341:Drug Evaluation; D004351:Drug Resistance; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D011433:Propranolol / Q000627:therapeutic use*; D012083:Renin / Q000097:blood*; D013997:Time Factors
D000450:Aldosterone; D011433:Propranolol; D012083:Renin
Vliianie obzidana na pokazateli gemodinamiki, uroven' renina i al'dosterona v plazme krovi bol'nykh s iuvenil'noĭ gipertonieĭ.