Prenatal and postnatal effects of low-level lead exposure: integrated summary of a report to the U.S. Congress on childhood lead poisoning.
This article provides an integrated summary of a report to Congress from the Federal government (ATSDR) on childhood lead poisoning in the United States, with particular reference to low-level lead exposure and its effects on the fetus and the preschool child. As mandated by Section 118(f)(1)(C) of the 1986 Superfund Amendments and Reauthorization Act (SARA), ATSDR has examined the full spectrum of human in utero and postnatal lead toxicity, with emphasis on low-level neurotoxicity and adverse impacts on growth indices in risk populations. Especially important has been assessment of the relative persistence of these effects in later life as discernible from a number of longitudinal studies now under way around the world. Included in the Congressional report were discussions of dose-effect and dose-response relationships using blood lead levels as the indicator of lead dose.
Mushak
P
P
Department of Pathology, University of North Carolina, Chapel Hill 27514.
Davis
J M
JM
Crocetti
A F
AF
Grant
L D
LD
D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007854:Lead / Q000378:metabolism / Q000633:toxicity*; D007855:Lead Poisoning / Q000453:epidemiology* / Q000473:pathology; D009420:Nervous System / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D014481:United States
D007854:Lead