title: Prophylaxis in gynaecological surgery: a prospective randomized comparison between single dose prophylaxis with amoxycillin/clavulanate and the combination of cefuroxime and metronidazole.
abstract: A prospective randomized comparison of a single pre-operative dose of 2.2 g amoxycillin/clavulanate versus the combination of 1.5 g cefuroxime plus 0.5 g metronidazole was conducted in 467 women, who underwent gynaecological surgery. The incidence of febrile morbidity, urinary tract infection, wound infection and the use of post-operative antimicrobial agents was similar in the two groups. Amoxycillin/clavulanate is as effective as a combination of cefuroxime and metronidazole and less expensive.
authors.affiliation: Department of Obstetrics and Gynaecology, Stichting Ignatius Ziekenhuis, Breda, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Friese
authors.forename: F T
authors.initials: FT
authors.lastname: Willems
authors.forename: S M
authors.initials: SM
authors.lastname: Loriaux
authors.forename: J M
authors.initials: JM
authors.lastname: Meewis
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use*; D002444:Cefuroxime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002969:Clavulanic Acids / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005836:Genitalia, Female / Q000601:surgery*; D006801:Humans; D007044:Hysterectomy; D007045:Hysterectomy, Vaginal; D007813:Laparotomy; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D011292:Premedication; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014552:Urinary Tract Infections / Q000517:prevention & control
chemical_list: D002511:Cephalosporins; D002969:Clavulanic Acids; D008795:Metronidazole; D000658:Amoxicillin; D002444:Cefuroxime