Inactivity of ethyl acrylate in the mouse bone marrow micronucleus assay.
We report ethyl acrylate to be inactive as a micronucleus-inducing agent in the bone marrow of mice following its i.p. injection in either corn oil or water. These data contrast with a strong positive response in this assay reported earlier. This discrepancy is discussed.
Ashby
J
J
ICI Central Toxicology Laboratory, Macclesfield, Cheshire, UK.
Richardson
C R
CR
Tinwell
H
H
D000179:Acrylates / Q000633:toxicity*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism; D002273:Carcinogens; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D015162:Micronucleus Tests; D009153:Mutagens
D000179:Acrylates; D002273:Carcinogens; D009153:Mutagens; C040833:ethyl acrylate