[Determination of unchanged clonazepam in plasma by gas-liquid chromatography].
A gas-liquid chromatography method for unchanged clonazepam determination in plasma using a nitrogen-phosphorus detector is presented. The drug is extracted from buffered plasma at pH 9.0 with benzen. The proposed method is simple, rapid and permits to determine clonazepam with a good precision (delta = 3.10 p. cent) and reproductibility (CV = 3.04 p. cent). The method allows the determination of other benzodiazepins. Plasmatics levels of inchanged clonazepam had been determined on some clinical cases.
Marliac
Y
Y
Laboratoire de Toxicologie, Faculté de Pharmacie, Université de Bordeaux II.
Barazi
S
S
D001569:Benzodiazepines / Q000097:blood; D002849:Chromatography, Gas / Q000295:instrumentation / Q000379:methods*; D002986:Clinical Trials as Topic; D002998:Clonazepam / Q000097:blood*; D005069:Evaluation Studies as Topic; D006801:Humans; D015203:Reproducibility of Results
D001569:Benzodiazepines; D002998:Clonazepam
Dosage du clonazépam inchangé dans le plasma par chromatographie gaz-liquide.