Adrenal chromaffin cells as transplants in animal models of Parkinson's disease.
The field of neural transplantation has moved rapidly forward in the last decade. Initially, fetal cells were used as implants to investigate their potential to ameliorate deficits in animal models of Parkinson's disease. However, because of the moral and legal problems associated with the use of fetal tissues in humans, alternative sources of donor tissue were sought which possessed the structural and functional characteristics needed to improve motor function in Parkinsonian patients. To date, one of the most promising tissues being investigated is the adrenal medulla, whose chromaffin cells possess an inherent plasticity of form and function. Transplanted chromaffin cells currently are being studied by a variety of approaches, including electron microscopy, in mouse, rat, and primate models of Parkinson's disease. An overview of the role of the chromaffin cell in this exciting and clinically important arena is briefly reviewed, with an emphasis on the fine structure of implanted chromaffin cells.
Hansen
J T
JT
Department of Neurobiology and Anatomy, University of Rochester School of Medicine, New York 14642.
Bing
G Y
GY
Notter
M F
MF
Kordower
J H
JH
Fiandaca
M S
MS
Gash
D M
DM
D000313:Adrenal Medulla / Q000166:cytology* / Q000637:transplantation; D000818:Animals; D001921:Brain / Q000601:surgery*; D002838:Chromaffin System / Q000637:transplantation*; D004195:Disease Models, Animal; D006801:Humans; D009473:Neuronal Plasticity; D010233:Paraganglia, Chromaffin / Q000637:transplantation* / Q000648:ultrastructure; D010300:Parkinson Disease / Q000601:surgery*