title: [Detection and determination of the biological activity of IgG Fc receptors in strains of streptococci isolated from carriers and patients].
abstract: Mechanism of anti-IgG induction during the immunization of animals by IgG Fc+ streptococcal strains has been studied. Streptococcal proteolytic activity did not influence microbial IgG Fc-receptor ability to induce synthesis of anti-IgG. The induction of anti-IgG by purified Fc-receptors and rabbit IgG, eluted from streptococcal IgG Fc-receptors has been examined. Biological activity of streptococcal IgG Fc+ strains, isolated from carriers and patients with acute streptococcal diseases has been evaluated according to their ability to induce synthesis of anti-IgG; data on the distribution of IgG Fc+ and IgG Fc- streptococcal strains among carriers and patients with streptococcal diseases are presented. IgG Fc+ strains were mostly isolated from patients with streptococcal diseases. Mechanisms of the transformation of rabbit IgG into autoantigen are discussed.
authors.forename: L A
authors.initials: LA
authors.lastname: Burova
authors.forename: I V
authors.initials: IV
authors.lastname: Koroleva
authors.forename: A A
authors.initials: AA
authors.lastname: Totolian
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis; D002353:Carrier State / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D011817:Rabbits; D011961:Receptors, Fc / Q000276:immunology*; D013290:Streptococcal Infections / Q000276:immunology*; D013297:Streptococcus pyogenes / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D011961:Receptors, Fc
vernacular_title: Vyiavlenie i otsenka biologicheskoĭ aktivnosti IgG Fc-retseptorov u shtammov streptokokkov, vydelennykh ot nositeleĭ i bol'nykh.