Effect of anti-diabetic treatment on high density lipoprotein-composition and lecithin:cholesterol acyltransferase activity--a comparison between insulin, sulfonylurea and diet alone treatments.
To determine the effect of diabetic treatment on plasma high density lipoprotein (HDL) composition and lecithin: cholesterol acyltransferase (LCAT) activity, 196 diabetic patients admitted to our hospital to receive diabetic control were divided into three groups according to the type of treatments; insulin treated group (91 patients), sulfonylurea group (56) and diet alone group (49). Plasma lipids, lipoproteins, apolipoproteins and LCAT activity were measured before and after the admission for 2-3 weeks. As compared with the pre-admission, the following results were obtained at the time of discharge in each group. 1) Body weight, fasting blood glucose, triglyceride, total cholesterol, apolipoproteins (A-I, A-II, C-II, C-III, E) were significantly decreased in each group. 2) Apoliprotein A-I/A-II ratio was significantly increased from 4.9 to 5.3 in insulin treated group (p less than 0.001). 3) Total HDL-cholesterol was significantly decreased in diet alone and sulfonylurea groups, however HDL 3-cholesterol was significantly decreased in sulfonylurea and insulin group. Then HDL 2-cholesterol/HDL 3-cholesterol ratio was significantly increased from 4.8 to 5.1 (p less than 0.001) in insulin group. 4) LCAT activity were significantly decreased from 790 to 637 (nmol/ml.h) (p less than 0.05) in insulin group, but did not change in other two groups. In conclusion, compared to diet alone and sulfonylurea groups, insulin group made significant reduction of HDL 3-cholesterol and LCAT activity during hospitalization.
Iizuka
T
T
Institute for Diabetes Care and Research, Asahi Life Foundation, Tokyo, Japan.
D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood* / Q000628:therapy; D003927:Diet, Diabetic; D005260:Female; D006760:Hospitalization; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D013453:Sulfonylurea Compounds; D014280:Triglycerides; D007862:Phosphatidylcholine-Sterol O-Acyltransferase