[Role of the processes of repair of DNA damage in the repair of cytogenetic disorders. Participation of the repair of DNA single-strand breaks in the repair of cytogenetic disorders].
A comparison was made between the results of the effect of poly(ADP-ribosylation) inhibitors (e.g. nicotinamide and 3-aminobenzamide) and a chromatin proteinase inhibitor, phenylmethylsulfonylfluoride, on the cytogenetic damages repair, by a micronucleus test and DNA repair in Chinese hamster fibroblasts. The values of the repair half-periods (5-7 min for the cytogenetic damages and 5 min for the rapidly repaired DNA damages) and a similar modifying effect with regard to radiation cytogenetic damages and kinetics of DNA damages repair were found to be close. This confirms the contribution of repair of DNA single-strand breaks in the initiation of structural damages to chromosomes.
Rozanova
O M
OM
Zaichkina
S I
SI
Aptikaeva
G F
GF
Ganassi
E E
EE
D000818:Animals; D002875:Chromosomes / Q000528:radiation effects*; D003037:Cobalt Radioisotopes; D006224:Cricetinae; D003412:Cricetulus; D004260:DNA Repair; D004277:DNA, Single-Stranded / Q000528:radiation effects*; D005720:Gamma Rays; D066298:In Vitro Techniques; D015162:Micronucleus Tests
D003037:Cobalt Radioisotopes; D004277:DNA, Single-Stranded
Rol' protsessov reparatsii povrezhdeniĭ DNK v reparatsii tsitogeneticheskikh narusheniĭ. Uchastie reparatsii odnonitevykh razryvov DNK v reparatsii tsitogeneticheskikh narusheniĭ.