title: Effect of starvation and insulin in vivo on the activity of the pyruvate dehydrogenase complex in rat skeletal muscles.
abstract: The in vivo responses of pyruvate dehydrogenase (PDH) complex to starvation and insulin was assessed in heart, diaphragm and red quadriceps muscle. PDH complex activity was decreased by starvation (3.4-10.2-fold), the magnitude of change depending on muscle type. Insulin increased PDH activity in all muscle types. In fed rats, this effect was relatively small (1.25-1.29-fold). In starved rats there were effects in heart (4.3-fold) and red quadriceps (1.7-fold) but no effect in diaphragm. These results demonstrate that PDH complex in different groups of muscle has different insulin sensitivity (particularly in tissues from starved animals).
authors.affiliation: Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: G S
authors.initials: GS
authors.lastname: Denyer
authors.forename: D
authors.initials: D
authors.lastname: Lam
authors.forename: G J
authors.initials: GJ
authors.lastname: Cooney
authors.forename: I D
authors.initials: ID
authors.lastname: Caterson
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000201:enzymology; D000818:Animals; D002950:Citrate (si)-Synthase / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D008931:Mitochondria, Muscle / Q000187:drug effects* / Q000201:enzymology; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation
chemical_list: D007328:Insulin; D011768:Pyruvate Dehydrogenase Complex; D002950:Citrate (si)-Synthase