title: Pharmacokinetic interactions of penicillamine in rheumatoid arthritis.
abstract: The pharmacokinetic effect of the combined treatment of penicillamine with indomethacin and chloroquine was investigated in patients with rheumatoid arthritis. The mean plasma penicillamine concentration increased by 26% during indomethacin and 34% during chloroquine treatment. This new pharmacokinetic interaction may have important clinical implications.
authors.affiliation: Department of Internal Medicine, Danderyed Hospital, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Seideman
authors.forename: B
authors.initials: B
authors.lastname: Lindström
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002738:Chloroquine / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011897:Random Allocation
chemical_list: D002738:Chloroquine; D010396:Penicillamine; D007213:Indomethacin