title: [Detection of cellular proto-oncogenes and oncogenes].
abstract: Detection of proto-oncogenes in normal cells and oncogenes in cells of solid tumors and in leukemic cells confirmed the assumption on the genetic basis of neoplastic cell transformation. Proto-oncogenes constitute a specific group of genes involved in physiological processes of the cell. Inappropriately expressed forms of proto-oncogenes are referred to as oncogenes. Proto-oncogenes and oncogenes were detected either by means of animal oncogenic viruses, in in vitro transfection experiments, or by means of some cytological methods revealing chromosomal abnormalities. Proto-oncogenes were detected in cells of phylogenetically very distant species, suggesting their importance in the regulation of the cell cycle.
authors.forename: E
authors.initials: E
authors.lastname: Weismanová
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D005821:Genetic Techniques; D006801:Humans; D007938:Leukemia / Q000235:genetics; D051379:Mice; D009369:Neoplasms / Q000235:genetics; D009857:Oncogenes / Q000502:physiology; D011519:Proto-Oncogenes / Q000502:physiology; D014162:Transfection; D014178:Translocation, Genetic
vernacular_title: Detekcia bunkových proto-onkogénov a onkogénov.