Role of Ca2+ in toxic cell killing.
Recent work has shown that a sustained increase in cytosolic Ca2+ concentration is often linked to the onset of cytotoxicity. Sten Orrenius and colleagues describe several biochemical mechanisms that are stimulated by such a Ca2+ increase and can directly mediate cell death by causing disruption of the cytoskeleton, DNA fragmentation and extensive damage to other cell components.
Orrenius
S
S
McConkey
D J
DJ
Bellomo
G
G
Nicotera
P
P
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002470:Cell Survival; D006801:Humans
D002118:Calcium