Influence of captopril on the vasopressor effect of serotonin in pithed rats.
In pithed rats intravenous administration of serotonin (5.0, 10.0, 20.0, 30.0 and 50.0 micrograms/kg) produced a dose-dependent increase in blood pressure. The pressor response to serotonin was significantly reduced by captopril (1.0, 5.0 and 50.0 mg/kg) in a dose-dependent manner. Captopril did not attenuate the response of the isolated tail artery to serotonin (5-HT) and did not amplify the dilator effect of serotonin in pithed rats pretreated with ketanserin (1.0 mg/kg). These data suggest that the action of captopril does not depend on its influence on serotoninergic receptors in blood vessels.
Malinowska
B
B
Department of Pharmacodynamics, Medical School, Białystok, Poland.
Buczko
W
W
D000818:Animals; D001158:Arteries / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology*; D003655:Decerebrate State; D004305:Dose-Response Relationship, Drug; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*; D013623:Tail / Q000098:blood supply
D012701:Serotonin; D007650:Ketanserin; D002216:Captopril