title: Diabetic fibrous breast disease.
abstract: Women with long-standing insulin-dependent diabetes mellitus (IDDM) and radiographically dense mammary glandular tissue can have benign breast masses clinically resembling cancer. The authors have identified 36 patients, aged 20-54 years, with this little-known condition, which the authors call diabetic fibrous breast disease (DFBD). For a diagnosis of DFBD, the patient must fulfill certain stringent requirements: a long-term history of IDDM; radiographically dense glandular tissue; and one or more hard, irregular, easily movable, discrete, painless, palpable breast masses with strong ultrasonographic acoustical shadowing and firm resistance to the back-and-forth motion of the needle used for fine-needle aspiration cytology (FNAC). Patients meeting all criteria can be monitored with serial FNAC procedures to prevent them from undergoing multiple surgical biopsies. During an average of 6 years of monitoring these 36 women, breast cancer did not develop in any mass fulfilling all requirements for DFBD.
authors.affiliation: Breast Clinic of Rochester, NY 14620.
authors.forename: W W
authors.initials: WW
authors.lastname: Logan
authors.forename: N Y
authors.initials: NY
authors.lastname: Hoffman
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D001940:Breast / Q000473:pathology; D001941:Breast Diseases / Q000175:diagnosis / Q000209:etiology*; D001943:Breast Neoplasms / Q000175:diagnosis; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D014463:Ultrasonography