Enhanced transcription of c-myc proto-oncogene in spleen lymphocytes from lupus-prone mice during the growing process.
The expression of c-myc proto-oncogene in spleen lymphocytes has been studied in lupus-prone mice (MRL/Mp-lpr/lpr), an animal model for the human autoimmune disease systemic lupus erythematosus, during the growing process, in comparison to control mice (MRL/Mp-+/+). By Northern blot assay and nuclear run on transcription assay, we demonstrated the enhancement of c-myc proto-oncogene expression in spleen lymphocytes from lupus-prone mice in comparison to control mice and the level of expression of c-myc proto-oncogene increased during the growing process and deterioration of lupus symptoms, such as production of autoantibodies and lymphoproliferation, in this study.
Deguchi
Y
Y
Third Department of Internal Medicine, Osaka University School of Medicine, Japan.
Kishimoto
S
S
D000818:Animals; D015152:Blotting, Northern; D002467:Cell Nucleus / Q000502:physiology; D005786:Gene Expression Regulation; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008214:Lymphocytes / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains / Q000254:growth & development*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc; D013154:Spleen / Q000502:physiology; D014158:Transcription, Genetic
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc