[Effect of pimobendan on peripheral hemodynamics].
Peripheral hemodynamics and some metabolic parameters were studied in 20 patients with coronary artery disease (x = 59 +/- 9 y) and in 20 healthy volunteers (x = 25 +/- 3 y) at rest and after isometric handgrip exercise both before and after administration of pimobendan or placebo using a randomized, double-blind study. Forearm blood flow was measured using venous occlusion plethysmography. In pimobendan treated patients and volunteers an increase in forearm blood flow between 9% and 38% could be noticed. The increase in forearm blood flow was significant in comparison to placebo only, in volunteers under resting conditions. Heart rate increased significantly by 14-19% in all groups after administration of pimobendan. There were no alterations in blood pressure. Local resistance in forearm fell by 13-22%. Pimobendan did not change metabolic parameters.
Peters
P
P
Medizinische Klinik Holweide, Universität zu Köln.
Saborowski
F
F
Kothe
A
A
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy*; D004311:Double-Blind Method; D005080:Exercise Test; D005542:Forearm / Q000098:blood supply; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D011724:Pyridazines / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use*
D011724:Pyridazines; D014665:Vasodilator Agents; C041648:pimobendan
Einfluss von Pimobendan auf die periphere Hämodynamik.