title: Elongation factor EF-1 alpha gene dosage alters translational fidelity in Saccharomyces cerevisiae.
abstract: Changes in the dosage of genes encoding elongation factor EF-1 alpha were shown to cause parallel changes in the misreading of nonsense codons. Higher amounts of EF-1 alpha were correlated with increased nonsense suppression, suggesting that the level of EF-1 alpha is critically involved in translational fidelity.
authors.affiliation: Department of Biological Sciences, University of Illinois, Chicago 60680.
authors.forename: J M
authors.initials: JM
authors.lastname: Song
authors.forename: S
authors.initials: S
authors.lastname: Picologlou
authors.forename: C M
authors.initials: CM
authors.lastname: Grant
authors.forename: M
authors.initials: M
authors.lastname: Firoozan
authors.forename: M F
authors.initials: MF
authors.lastname: Tuite
authors.forename: S
authors.initials: S
authors.lastname: Liebman
mesh_terms: D003001:Cloning, Molecular; D005784:Gene Amplification / Q000502:physiology; D010303:Paromomycin / Q000494:pharmacology; D020648:Peptide Elongation Factor 1; D010445:Peptide Elongation Factors / Q000096:biosynthesis / Q000235:genetics*; D014176:Protein Biosynthesis / Q000502:physiology*; D015183:Restriction Mapping; D012441:Saccharomyces cerevisiae / Q000235:genetics; D013489:Suppression, Genetic / Q000502:physiology
chemical_list: D020648:Peptide Elongation Factor 1; D010445:Peptide Elongation Factors; D010303:Paromomycin