title: Randomized comparison of outcome after propofol-nitrous oxide or enflurane-nitrous oxide anaesthesia in operations of long duration.
abstract: A randomized, prospective, comparative study was performed to evaluate induction characteristics, haemodynamic changes and recovery in 60 ASA I-II patients undergoing mainly gynaecological laparotomies with either propofol or thiopentone-enflurane anaesthesia. The propofol group (n = 30) received 2 mg.kg-1 propofol for induction of anaesthesia followed by propofol infusion. The thiopentone-enflurane group (n = 30) received thiopentone 4 mg.kg-1 for induction followed by enflurane (0.5-2 per cent). All patients received nitrous oxide (66 per cent] in oxygen begun one minute after tracheal intubation, and fentanyl (1.5 micrograms.kg-1) four minutes prior to induction. Other drugs administered during or after anaesthesia were similar among the groups. Haemodynamic measurements were similar between propofol and enflurane groups except after tracheal intubation when the mean arterial pressure was lower in the propofol group (P less than 0.05). The propofol group had significantly less (P less than 0.01) emesis in the recovery room than the enflurane group. The propofol group experienced significantly less (P less than 0.05) dizziness, depression/sadness and hunger than the enflurane group in the postoperative period as assessed with a visual analogue questionnaire. We conclude that propofol provided better outcome than enflurane in terms of these nonvital but annoying outcome measures after relatively long intra-abdominal operations.
authors.affiliation: Department of Anesthesia and Critical Care, University of Chicago, Illinois.
authors.forename: K
authors.initials: K
authors.lastname: Korttila
authors.forename: P L
authors.initials: PL
authors.lastname: Ostman
authors.forename: E
authors.initials: E
authors.lastname: Faure
authors.forename: J L
authors.initials: JL
authors.lastname: Apfelbaum
authors.forename: M
authors.initials: M
authors.lastname: Ekdawi
authors.forename: M F
authors.initials: MF
authors.lastname: Roizen
mesh_terms: D000328:Adult; D000758:Anesthesia; D001794:Blood Pressure / Q000187:drug effects; D004737:Enflurane / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D015742:Propofol / Q000009:adverse effects; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced
chemical_list: D004737:Enflurane; D009609:Nitrous Oxide; D015742:Propofol