title: Pharmacology of the colony-stimulating factors.
abstract: Leukocyte production is influenced by a family of glycoproteins called colony-stimulating factors. Two of these have been purified, cloned and produced in quantities sufficient for clinical use. Granulocyte colony-stimulating factor (G-CSF) preferentially stimulates neutrophil production and has been shown to reduce the duration of neutropenia following chemotherapy. G-CSF therapy also has beneficial effects in a variety of other neutropenic states. Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates neutrophil, monocyte and eosinophil production and function. GM-CSF is associated with more diverse haematological and clinical effects. George Morstyn and colleagues summarize the promising results from the early clinical trials with these new therapeutic agents.
authors.forename: G
authors.initials: G
authors.lastname: Morstyn
authors.forename: G J
authors.initials: GJ
authors.lastname: Lieschke
authors.forename: W
authors.initials: W
authors.lastname: Sheridan
authors.forename: J
authors.initials: J
authors.lastname: Layton
authors.forename: J
authors.initials: J
authors.lastname: Cebon
mesh_terms: D000818:Animals; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D006801:Humans
chemical_list: D003115:Colony-Stimulating Factors