Synthesis of cis-bicyclo[4.3.0]non-2-ene derivatives. The potent homoisocarbacyclin analogs.
Synthesis of homoisocarbacyclin has been achieved efficiently by a general strategy with stereo- and regiochemical control. One of homoisocarbacyclin derivatives, 3-oxa homoisocarbacyclin analog (4), was shown to be potently active in inhibiting gastric ulcer. Another analog, conjugated diene derivative (5), was found to have a biological profile similar to prostacyclin.
Shibasaki
M
M
Takahashi
A
A
Aoki
T
T
Sato
H
H
Narita
S
S
D000897:Anti-Ulcer Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D011464:Epoprostenol / Q000138:chemical synthesis* / Q000494:pharmacology / Q000031:analogs & derivatives
D000897:Anti-Ulcer Agents; C061101:bicyclo(4.3.0)non-2-ene homoisocarbacyclin; C061100:3-oxahomoisocarbacyclin; C061099:homoisocarbacyclin; D011464:Epoprostenol