Analysis of fetal loss after transcervical chorionic villus sampling--a review of 719 patients.
Chorionic villus sampling was performed under real-time ultrasonographic direction on a study group of 719 patients from September 9, 1985, through May 5, 1988. Follow-up of 714 of these patients who would have reached 28 weeks' gestation on September 1, 1988, revealed "an unintended" abortion rate of 4.1% by 20 weeks' gestation. Nine patients had a fetal loss less than 4 weeks after the procedure; 19 had losses up to 12 weeks after the procedure and before 20 weeks' gestation. This study revealed a significantly increased risk of fetal loss with an increase in the number of catheter insertions (p less than 0.001). The risk of fetal loss after one sampling attempt was 3%, 7.8% after two attempts, and 14.3% after three attempts.
Wade
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RV
Department of Obstetrics and Gynecology, University of South Carolina School of Medicine, Columbia.
Young
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SR
D000022:Abortion, Spontaneous / Q000209:etiology*; D000328:Adult; D015193:Chorionic Villi Sampling / Q000009:adverse effects*; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D007621:Karyotyping; D008423:Maternal Age; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D018566:Pregnancy, High-Risk; D011296:Prenatal Diagnosis / Q000379:methods*; D012307:Risk Factors; D014463:Ultrasonography