title: [Treatment of pneumonia caused by Legionella, Mycoplasma, Chlamydiae and Rickettsia using ofloxacin].
abstract: To asses the efficacy and the safety of ofloxacin as therapy of pneumonia caused by intracellular pathogens, 35 patients were studied (26 male, 9 female, mean age: 52.5 +/- 16.6 years). Causative pathogens were Chlamydia psittaci (n = 13), Legionella pneumophila (n = 10), Mycoplasma pneumoniae (n = 7) and Coxiella burnetii (n = 5). Ofloxacin was administered orally in 32 cases (200 mg b.i.d. in 80% of cases) and by I.V. route in 3 cases. All patients were cured without any side effects. In conclusion, ofloxacin appears, in our study, as an efficient therapy for these pneumonias. It could be considered as a valuable alternative to other antimicrobial agents with intra-cellular activity.
authors.affiliation: Service Régional des Maladies Infectieuses et Parasitaires, Centre Hospitalier de Tourcoing, France.
authors.forename: O
authors.initials: O
authors.lastname: Leroy
authors.forename: C
authors.initials: C
authors.lastname: Beuscart
authors.forename: C
authors.initials: C
authors.lastname: Chidiac
authors.forename: B
authors.initials: B
authors.lastname: Sivery
authors.forename: E
authors.initials: E
authors.lastname: Senneville
authors.forename: M
authors.initials: M
authors.lastname: Vincent du Laurier
authors.forename: Y
authors.initials: Y
authors.lastname: Mouton
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007877:Legionnaires' Disease / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D015242:Ofloxacin / Q000627:therapeutic use*; D011019:Pneumonia, Mycoplasma / Q000188:drug therapy / Q000453:epidemiology; D011022:Pneumonia, Rickettsial / Q000188:drug therapy* / Q000453:epidemiology; D009956:Psittacosis / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D015242:Ofloxacin
vernacular_title: Traitement des pneumonies dues aux légionelles, mycoplasmes, Chlamydiae et rickettsies par l'ofloxacine.