title: [Prevention of stomatitis induced by anti-cancer drugs].
abstract: A randomized control trial study was carried out to evaluate the effect of allopurinol mouth wash on stomatitis induced by chemotherapy in gynecologic patients. Chemotherapeutics used consisted of 5-FU+CDDP (PF) given to 10 patients and vincristine and actinomycin-D+cyclophosphamide (VAC) given to 5. Allopurinol mouth wash was prepared for patients to rinse their mouth with the solution 4-5 times daily before and after treatment with anti-cancer drugs. The Japan Society For Cancer Therapy's criteria for stomatitis were used. In the control group, stomatitis occurred in 9 of the 10 patients receiving PF therapy and in all of the 5 receiving VAC. In contrast, stomatitis was observed in only 2 of the 10 patients receiving PF therapy and 2 of the 5 VAC in the allopurinol-treated group. Allopurinol mouth wash showed a marked effect on stomatitis induced by chemotherapy.
authors.affiliation: Dept. of Gynecology, Faculty of Medicine, Kagoshima University.
authors.forename: H
authors.initials: H
authors.lastname: Dozono
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Motoya
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: R
authors.initials: R
authors.lastname: Shinmura
authors.forename: K
authors.initials: K
authors.lastname: Miwa
authors.forename: M
authors.initials: M
authors.lastname: Ishibashi
authors.forename: Y
authors.initials: Y
authors.lastname: Nagata
mesh_terms: D000493:Allopurinol / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D003609:Dactinomycin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D005833:Genital Neoplasms, Female / Q000188:drug therapy; D006801:Humans; D009061:Mouth Mucosa; D009067:Mouthwashes; D011897:Random Allocation; D013280:Stomatitis / Q000139:chemically induced / Q000517:prevention & control*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D009067:Mouthwashes; D003609:Dactinomycin; D014750:Vincristine; D000493:Allopurinol; D003520:Cyclophosphamide; D005472:Fluorouracil