title: [A clinical study of pulmonary edema on paraquat poisoning by double indicator dilution method using heat and sodium].
abstract: We studied the formation of pulmonary edema on 9 patients with paraquat poisoning using thermal-sodium double indicator dilution method for the measurement of lung water. In survivors group (n = 4) extravascular thermal volume (EVTV) was not almost changes. In non-survivors group (n = 5) EVTV increased about three times as much as that in survivors group on 32 hours after admission. EVTV was correlated with PCP-PCOP in both survivors group and non-survivors group (n = 64, r = 0.665, p less than 0.01). But EVTV in non-survivors group was higher than that in survivors group within same PCP-PCOP. In non-survivors group delta EVTV/delta (PCP-PCOP) in 24 hours after admission was correlated with initial PCP-PCOP (r = 0.984, p less than 0.01). We propose that the formation of pulmonary edema on paraquat poisoning is mainly due to the increased capillary permeability, influenced by the increased pressure gradient of capillary barrier.
authors.forename: I
authors.initials: I
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Sawada
authors.forename: M
authors.initials: M
authors.lastname: Ueyama
authors.forename: T
authors.initials: T
authors.lastname: Hirokane
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Ishibe
authors.forename: K
authors.initials: K
authors.lastname: Oono
authors.forename: T
authors.initials: T
authors.lastname: Yoshimitsu
mesh_terms: D000328:Adult; D000368:Aged; D002199:Capillary Permeability; D005110:Extracellular Space / Q000032:analysis*; D006801:Humans; D007201:Indicator Dilution Techniques; D008875:Middle Aged; D010269:Paraquat / Q000506:poisoning*; D011654:Pulmonary Edema / Q000209:etiology* / Q000378:metabolism
chemical_list: D010269:Paraquat