title: Familial congenital diaphragmatic hernia is an autosomal recessive variant.
abstract: Forty families that have had more than one sibling with a congenital diaphragmatic hernia have been identified. The 85 children among the 40 families describe a subset of congenital diaphragmatic hernia displaying an autosomal recessive inheritance mode. The chance of a diaphragmatic hernia among siblings within this subset is 25%.
authors.affiliation: Department of Surgery, Oklahoma Children's Memorial Hospital, University of Oklahoma, Oklahoma City.
authors.forename: D C
authors.initials: DC
authors.lastname: Hitch
authors.forename: J A
authors.initials: JA
authors.lastname: Carson
authors.forename: E I
authors.initials: EI
authors.lastname: Smith
authors.forename: D C
authors.initials: DC
authors.lastname: Sarale
authors.forename: O M
authors.initials: OM
authors.lastname: Rennert
mesh_terms: D015331:Cohort Studies; D000013:Congenital Abnormalities / Q000453:epidemiology / Q000235:genetics; D004200:Diseases in Twins; D005260:Female; D005808:Genes, Recessive; D006548:Hernia, Diaphragmatic / Q000453:epidemiology / Q000235:genetics; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010375:Pedigree