title: Urinary excretion of beta-2-microglobulin in patients with active metabolic stone disease.
abstract: The aim of the present work is to evaluate the function of the proximal tubule in patients with active metabolic stone disease (a.m.s.d.), recognizing the urinary excretion of beta-2-microglobulin (B2-M) as a sensitive marker of that function. The investigated group included 30 patients with a.m.s.d. accompanied by chronic pyelonephritis (CP) and 31 patients with a.m.s.d. without CP. The serum and urinary B2-M concentrations were estimated by radioimmunoassay. The clearance of B2-M (CB2-M) and the tubular reabsorption of B2-M (TRB2-M) were estimated. Patients with a.m.s.d. and CP showed an increased excretion of B2-M, significantly higher values of CB2-M and a significantly lower TRB2-M. The results indicate that the proximal tubular dysfunction in the group of patients with a.m.s.d. is a result of a chronic inflammatory process in the urinary tract.
authors.affiliation: Department of Cardiology, K. Marcinkowski Medical Academy, Poznań, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Musialik
mesh_terms: D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008659:Metabolic Diseases / Q000150:complications / Q000503:physiopathology / Q000652:urine*; D008875:Middle Aged; D011704:Pyelonephritis / Q000150:complications / Q000503:physiopathology / Q000652:urine*; D014545:Urinary Calculi / Q000150:complications / Q000503:physiopathology / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine*
chemical_list: D001613:beta 2-Microglobulin