title: Morphogens in chick limb development.
abstract: Retinoic acid is a good candidate for a morphogen in chick limb bud development. The challenge now is to determine how retinoic acid interacts with limb bud cells and how the retinoic acid signal is integrated with other signals to mould and pattern the developing limb.
authors.forename: P M
authors.initials: PM
authors.lastname: Brickell
authors.forename: C
authors.initials: C
authors.lastname: Tickle
mesh_terms: D000818:Animals; D002356:Cartilage / Q000187:drug effects; D002450:Cell Communication / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002642:Chick Embryo; D004475:Ectoderm / Q000187:drug effects; D006614:Hindlimb / Q000196:embryology*; D009024:Morphogenesis / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects; D014212:Tretinoin / Q000494:pharmacology*; D014801:Vitamin A / Q000502:physiology; D014921:Wings, Animal / Q000196:embryology
chemical_list: D014801:Vitamin A; D014212:Tretinoin