Localization of the murine macrophage colony-stimulating factor gene to chromosome 3 using interspecific backcross analysis.
The chromosomal location of the murine macrophage colony-stimulating factor (Csfm) gene was determined by interspecific backcross analysis. We mapped Csfm to mouse chromosome 3, 2.5 cM distal to Ngfb and Nras and 1.3 cM proximal to Amy-2. CSFM maps to human chromosome 5q, while AMY2, NGFB, and NRAS map to human chromosome 1p. The chromosomal location of Csfm thus disrupts a previously identified conserved linkage group between mouse chromosome 3 and human chromosome 1. The location of Csfm also identifies yet another mouse chromosome that shares synteny with human chromosome 5q, a region involved in several different types of myeloid disease.
Buchberg
A M
AM
Mammalian Genetics Laboratory, NCI-Frederick Cancer Research Facility, Maryland 21701.
Jenkins
N A
NA
Copeland
N G
NG
D000818:Animals; D015139:Blotting, Southern; D002895:Chromosomes, Human, Pair 5; D003115:Colony-Stimulating Factors / Q000235:genetics*; D003433:Crosses, Genetic; D008040:Genetic Linkage; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000235:genetics*; D006801:Humans; D008264:Macrophages; D051379:Mice / Q000235:genetics*; D008810:Mice, Inbred C57BL; D015183:Restriction Mapping
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016178:Granulocyte-Macrophage Colony-Stimulating Factor