Blood pressure and intracellular ion transport in childhood.
The available data on the association between the cellular handling of sodium and high BP indicate that alteration of these parameters could be linked to the level of high BP. Limited data are available with regard to the association between BP and these aspects of the intracellular ion metabolism in childhood. The study of intracellular ion metabolism in children could help clarify the pathogenesis and etiology of essential hypertension by providing an opportunity to study this relationship before the effects of possible determinants of adult BP (ie, age, body weight, diet, physical activity) affect ion transport and modify its effect on BP. Specifically, familial predisposition to hypertension, growth and maturation, and the various components of body size need to be studied further to determine their role in the relationship between Na-Li CT and RBC Na and BP. Better understanding of this complex association could help elucidate the pathophysiology of essential hypertension.
Trevisan
M
M
Department of Social and Preventive Medicine, State University of New York, Buffalo 14214.
Krogh
V
V
Dorn
J
J
De Santo
N G
NG
D001692:Biological Transport; D002648:Child; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008094:Lithium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*
D008094:Lithium; D012964:Sodium