An autopsy case of so-called midline malignant reticulosis followed by extensive dissemination with immunohistochemical evidence for its T cell malignancy.
An autopsy case of malignant midline reticulosis (MMR) is reported. The patient, a 42-year-old Japanese male, died after a clinical course of 22 months. Autopsy revealed extensive infiltration of generalized organs by the tumor cells, suggesting that the disease was highly malignant in nature. Staining with monoclonal antibodies against T-cell surface antigens Leu 4 on frozen sections and UCHL1 on paraffin-embedded sections enabled us to examine the phenotype of the tumor cells with good morphological preservation and to verify the T cell nature of the tumor.
Ohta
Y
Y
Department of Pathology, School of Medicine, Tokai University, Isehara, Japan.
Shimamura
K
K
Lertprasertsuke
N
N
Horiuchi
M
M
Osamura
R Y
RY
D000328:Adult; D000911:Antibodies, Monoclonal; D001344:Autopsy; D001853:Bone Marrow / Q000032:analysis / Q000473:pathology; D054747:Histiocytic Sarcoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000032:analysis / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000032:analysis / Q000473:pathology*; D008297:Male; D011379:Prognosis; D013601:T-Lymphocytes / Q000032:analysis / Q000473:pathology*
D000911:Antibodies, Monoclonal