Xanthine oxidase status in ethanol-intoxicated rat liver.
The status of xanthine oxidase in ethanol-induced liver injury has been investigated in the rat, by acute and chronic ethanol treatments. A 38% increase of the enzyme O-form was observed after repeated ethanol administration. Chronic intoxication caused a significant decrease of total xanthine oxidase activity after both prolonged ethanol feeding and life span ethanol ingestion. The intermediate D/O-form of xanthine oxidase (that can act either as an oxidase or as a dehydrogenase, being able to react with O2 as well as with NAD+ as electron acceptor) increased 5.5-fold after prolonged ethanol feeding.
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Dipartimento di Patologia Sperimentale, Bologna, Italy.
Battelli
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MG
Soffritti
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Cessi
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D000435:Alcoholic Intoxication / Q000201:enzymology*; D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D005260:Female; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014969:Xanthine Oxidase / Q000378:metabolism*
D014969:Xanthine Oxidase