[Improved life expectancy by prevention of atherosclerosis. Results of intervention studies for treatment of lipid metabolism disorders].
An elevated serum cholesterol level is one of the main risk factors for the development of atherosclerosis. In primary and secondary intervention trials it was shown that a reduction of total cholesterol in serum was accompanied by a reduction of the coronary risk: 1 percent decrease of serum cholesterol levels resulted in a reduction of coronary risk by 2 percent. Furthermore an increase of the antiatherogenic HDL cholesterol and lowering serum triglycerides cause a further decrease of the risk for the development of coronary heart disease. By controlled use of antilipidemic diets and drugs a prevention of atherosclerosis is possible resulting in an increase of life quality and expectancy.
Richter
W O
WO
Schwandt
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P
D000328:Adult; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003324:Coronary Artery Disease / Q000401:mortality / Q000517:prevention & control*; D004311:Double-Blind Method; D005860:Germany, West / Q000453:epidemiology; D006801:Humans; D006937:Hypercholesterolemia / Q000401:mortality / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008017:Life Expectancy; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D000960:Hypolipidemic Agents
Verbesserte Lebenserwartung durch Prävention der Atherosklerose. Ergebnisse von Interventionsstudien zur Behandlung von Fettstoffwechselstörungen.