Splenopentin-induced reconstitution of the immune response after total body irradiation: optimization of treatment regime.
In former investigations our group obtained an immuno-reconstituting effect in mice treated by immunosuppression after a continuous treatment with splenopentin (SP5). The goal of the present study was to test whether a small number of injections right after immunosuppression possibly produces the same result in the sense of an initial effect. Although a short-term therapy induced an increase of antibody formation which was measurable after 4 weeks, the study clearly showed that only a continuous treatment by SP5 led to an optimum, i.e. complete reconstitution of antibody formation.
Eckert
R
R
Institute of Medical Immunology, Medical School (Charité), Humboldt University, Berlin, GDR.
Schmidt
R
R
Volk
H D
HD
Diezel
W
W
Sönnichsen
N
N
von Baehr
R
R
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D010446:Peptide Fragments / Q000494:pharmacology*; D013946:Thymopoietins / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D000276:Adjuvants, Immunologic; D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; C041898:splenopentin