Darier's disease: an immunohistochemical study using antibodies to proteases.
The expression of plasminogen activators, plasminogen and fibrinogen was investigated in 10 specimens of normal skin and in the involved skin of seven males with Darier's disease, using immunohistochemical techniques. Changes in the localization of proteases were found in the involved skin of Darier's disease, plasminogen being expressed by suprabasal cells and fibrinogen being detected in the keratotic plug.
Burge
S M
SM
Department of Dermatology, Slade Hospital, Oxford, U.K.
Ryan
T J
TJ
Cederholm-Williams
S A
SA
D007644:Darier Disease / Q000201:enzymology*; D005340:Fibrinogen / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D010958:Plasminogen / Q000378:metabolism*; D010960:Plasminogen Activators / Q000378:metabolism*; D012867:Skin / Q000201:enzymology*
D005340:Fibrinogen; D010958:Plasminogen; D010960:Plasminogen Activators