title: Hypertriglyceridemia in bone marrow transplant recipients: another side effect of cyclosporine A.
abstract: The incidence and duration of hypertriglyceridemia (HTG) associated with allogeneic HLA-identical bone marrow transplantation (BMT) were investigated in 38 patients with normal triglyceride levels (TG) before BMT and without any evidence of prior liver disorder. Twenty-two (58%) patients developed HTG. The median of TG peak values was 350 mg/dl (range 215-908) and the median actuarial time for HTG appearance was 7 weeks (range 1-12). Among several variables analysed (age, sex, hyperglycemia, total parenteral nutrition, treatment with methylprednisolone, estrogens or cyclosporine A) only cyclosporine A administration was significantly associated with HTG development.
authors.affiliation: Postgraduate School of Haematology, Farreras Valenti Hospital Clínic, University of Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Carreras
authors.forename: N
authors.initials: N
authors.lastname: Villamor
authors.forename: J C
authors.initials: JC
authors.lastname: Reverter
authors.forename: J
authors.initials: J
authors.lastname: Sierra
authors.forename: A
authors.initials: A
authors.lastname: Grañena
authors.forename: C
authors.initials: C
authors.lastname: Rozman
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003524:Cyclosporins / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006648:Histocompatibility; D006801:Humans; D015228:Hypertriglyceridemia / Q000209:etiology* / Q000473:pathology; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008297:Male; D014184:Transplantation, Homologous
chemical_list: D003524:Cyclosporins; D006680:HLA Antigens; D007166:Immunosuppressive Agents