A new test for specific IgE to inhalant allergens (Phadiatop) in the screening of immediate respiratory hypersensitivity states.
Three hundred recruits were classified as either allergic or nonallergic to inhalant allergens on the basis of history, physical examination, skin testing, and RAST. Forty-nine (16.3%) were classified as allergic as they were affected by oculorhinitis and/or asthma. This diagnosis was compared with results obtained with PRIST and with a new commercially available multi-RAST test for inhalant allergy, Phadiatop (Pharmacia). Sixty subjects (20%), including all 49 allergic subjects, scored positive in the Phadiatop assay (100% sensitivity) while PRIST (cut-off 220 IU/mL) identified only 20/49 allergics (40.8% sensitivity). The correlation between RAST and Phadiatop was excellent. Phadiatop is much more sensitive than PRIST; furthermore, Phadiatop is easier, less expensive, and as reliable as RAST for use in mass screening programs.
Matricardi
P M
PM
Department of Medicine, DASRS, Pratica di Mare, Italy.
Fattorossi
A
A
Nisini
R
R
Le Moli
S
S
Castagliuolo
P P
PP
D'Amelio
R
R
D000293:Adolescent; D000328:Adult; D000485:Allergens; D000918:Antibody Specificity / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007073:Immunoglobulin E / Q000032:analysis*; D007558:Italy; D008297:Male; D008403:Mass Screening / Q000379:methods*; D011852:Radioallergosorbent Test; D011864:Radioimmunosorbent Test; D012130:Respiratory Hypersensitivity / Q000175:diagnosis / Q000517:prevention & control*; D012882:Skin Tests
D000485:Allergens; D007073:Immunoglobulin E