title: Treatment options in early breast cancer.
abstract: Conservative management of early breast cancer with limited surgical excision and radiotherapy is now being accepted as a viable alternative to mutilating surgical procedures. In this paper, the major steps in the historical development of conservative management are traced, and the results of the current randomized trials are summarized. An innovative method used at the University of Kansas Medical Center delivers a "boost" dose to the tumor bed with interstitial Ir-192 immediately following resection of the primary tumor mass. The results obtained in terms of local control and cosmesis with this technique are presented, and the current state of the art is discussed.
authors.affiliation: Department of Radiation Oncology, University of Kansas Medical Center, Kansas City 66103.
authors.forename: L
authors.initials: L
authors.lastname: Krishnan
authors.forename: E C
authors.initials: EC
authors.lastname: Krishnan
authors.forename: C M
authors.initials: CM
authors.lastname: Mansfield
authors.forename: E K
authors.initials: EK
authors.lastname: Reddy
authors.forename: J H
authors.initials: JH
authors.lastname: Thomas
authors.forename: W R
authors.initials: WR
authors.lastname: Jewell
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic