The hypotensive response to des-Arg9-bradykinin increases during E. coli septicemia in the pig.
The sensitivity to des-Arg9-bradykinin of the cardiovascular system was largely increased in piglets with E. coli bacteremia. However, the sensitivity to bradykinin was unchanged under the same condition. These findings indicate the appearance of the kinin B1-receptor in the systemic circulation of the pig during septicemia. Bradykinin induced responses suggest a stable effect mediated by the classical B2-receptor.
Siebeck
M
M
Chirurgische Klinik Innenstadt, University of Munich, West Germany.
Whalley
E T
ET
Hoffmann
H
H
Weipert
J
J
Fritz
H
H
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004927:Escherichia coli Infections / Q000503:physiopathology*; D012016:Reference Values; D018805:Sepsis / Q000503:physiopathology*; D013552:Swine
C024626:bradykinin, des-Arg(9)-; D001920:Bradykinin