title: The Salmonella typhimurium glycine cleavage enzyme system.
abstract: A glycine cleavage enzyme system, inducible by glycine, has been demonstrated in Salmonella typhimurium. The induced enzyme levels, however, are only about 20% of the induced levels found in Escherichia coli. Starting with a serine auxotroph, mutants were isolated that grow with a serine supplement, but not with a glycine supplement. Three independently isolated mutants have reduced or nondetectable glycine cleavage enzyme levels. The new mutations, designated gcv, were mapped between the serA and lys genes at 62.5 min on the S. typhimurium chromosome.
authors.affiliation: Department of Microbiology, University of Iowa, Iowa City 52242.
authors.forename: G V
authors.initials: GV
authors.lastname: Stauffer
authors.forename: L T
authors.initials: LT
authors.lastname: Stauffer
authors.forename: M D
authors.initials: MD
authors.lastname: Plamann
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000096:biosynthesis* / Q000235:genetics; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000235:genetics; D002874:Chromosome Mapping; D004926:Escherichia coli / Q000235:genetics; D005998:Glycine / Q000378:metabolism; D009097:Multienzyme Complexes / Q000096:biosynthesis* / Q000235:genetics; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D014161:Transduction, Genetic; D014166:Transferases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D002352:Carrier Proteins; D009097:Multienzyme Complexes; C064525:glycine cleavage system; D000594:Amino Acid Oxidoreductases; D014166:Transferases; D005998:Glycine