CA 125 in the epithelium closely related to the embryonic ectoderm: the periderm and the amnion.
The amnion is believed to be derived from either cytotrophoblastic cells or embryonic ectoderm. However, it produces and secretes CA 125, which is considered a differentiation antigen of fetal coelomic epithelium derived from the mesoderm of germ cells. To verify this, the immunohistochemical localization of CA 125 in human fetal tissues (between 7 and 23 weeks of gestation) derived from the ectoderm, endoderm, or mesoderm, and in the fetal membranes and placenta was studied. Among the mesoderm-derived tissues, only the fetal coelomic epithelium-related tissues were positive for anti-CA 125 from 15 weeks of gestation. The endoderm-derived tissues did not react with anti-CA 125. However, among the ectoderm-derived tissues, only the periderm reacted with anti-CA 125 from 7 weeks until it sloughed from the stratum intermedium by 23 weeks of gestation. Among the fetal membranes and placenta, only the amnion reacted with anti-CA 125 from 9 weeks to term. These findings indicate that the amnion and the periderm, both of which constitute the epithelia covering the amniotic cavity, in addition to the fetal coelomic epithelium-related tissues, produce CA 125.
Nanbu
Y
Y
Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Japan.
Fujii
S
S
Konishi
I
I
Nonogaki
H
H
Mori
T
T
D000650:Amnion / Q000276:immunology*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D004475:Ectoderm / Q000276:immunology*; D004707:Endoderm / Q000276:immunology; D004848:Epithelium / Q000276:immunology; D005321:Extraembryonic Membranes / Q000276:immunology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008297:Male; D008648:Mesoderm / Q000276:immunology; D010920:Placenta / Q000276:immunology; D011247:Pregnancy
D015295:Antigens, Tumor-Associated, Carbohydrate