title: Simulation of the diffusion of the beta-globin variants in the Old World.
abstract: The distributions of the major hemoglobin variants found in the Old World are simulated assuming that each of the S, C, and E variants had a single origin and that beta-thalassemia occurred as many different mutations. The present distributions of these variants are considered unstable and were best approximated after about 100-150 generations of diffusion and selection. The model is considered to approximate the distributions of these variants better than hypotheses based on multiple mutations.
authors.forename: F B
authors.initials: FB
authors.lastname: Livingstone
mesh_terms: D000354:Africa, Western; D001210:Asia, Southeastern; D003198:Computer Simulation; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D005914:Globins / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics; D049691:History, Medieval; D006801:Humans; D007194:India; D008288:Malaria / Q000235:genetics; D008877:Middle East; D011110:Polymorphism, Genetic / Q000235:genetics*; D013789:Thalassemia / Q000235:genetics / Q000266:history
chemical_list: D006455:Hemoglobins, Abnormal; D005914:Globins