Advancing age and acute infection influence the kinetics of ceftazidime.
The pharmacokinetics of ceftazidime were studied after single intravenous injections of 2 g in 10 healthy, elderly male volunteers (63-76 years old). None of the subjects were on concurrent drug treatment and all had normal age-correlated glomerular filtration rate. Mean values for major pharmacokinetic variables were: terminal half-life 2.63 h, area under the serum concentration curve 417.6 h mg/l, total clearance 74.6 ml/(min 1.73 m2), renal clearance 53.6 ml/(min 1.73 m2), urinary recovery/12 h 71.7% of dose and apparent volume of distribution (Vss) 15.0 l/1.73 m2. Data were compared with our earlier findings in studies of young male volunteers and elderly, acutely ill male patients. Advanced age was accompanied by a reduction in clearance of ceftazidime, while no significant age-related changes in distribution were noted. Acute infection was associated with increased Vss and enhanced renal clearance; alterations possibly caused by fever-induced changes in vascular permeability and renal blood-flow.
Ljungberg
B
B
Department of Infectious Diseases, University of Lund, Sweden.
Nilsson-Ehle
I
I
D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000368:Aged; D001424:Bacterial Infections / Q000378:metabolism*; D002442:Ceftazidime / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged
D002442:Ceftazidime