title: Genetic resistance of hosts and its influence on epidemiology.
abstract: Evidence for the genetic control of resistance of sheep to gastrointestinal nematode infections was reviewed and compared with that of cattle to infestation with the cattle tick. Variation within sheep breeds in resistance to nematode infection is as great as that between breeds, is moderately heritable, and selection of lines of resistant sheep should result in animals carrying worm burdens around 10%-20% of those of unselected animals. The consequences of genetically resistant sheep for the epidemiology of Trichostrongylus colubriformis infection were examined with the aid of a simulation model. Predicted results were similar to those observed in cattle herds resistant to Boophilus microplus; seasonal peaks in parasite burdens were greatly reduced, and larval numbers on pasture were reduced even further. The use of genetically resistant hosts should permit a reduced frequency of anthelmintic treatment, and hence reduce the rate of development of anthelmintic resistance in the parasite.
authors.affiliation: CSIRO Division of Animal Health, Pastoral Research Laboratory, Armidale NSW, Australia.
authors.forename: I A
authors.initials: IA
authors.lastname: Barger
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000276:immunology*; D007113:Immunity, Innate; D009349:Nematode Infections / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology / Q000276:immunology*; D013984:Tick Infestations / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*