The ketoconazole-cyclosporin interaction in an elderly renal transplant patient.
Administration of ketoconazole to an elderly renal transplant patient who was taking cyclosporin resulted in markedly increased whole blood cyclosporin concentrations and evidence of both renal and hepatic dysfunction.
Charles
B G
BG
Department of Clinical Pharmacology, Princess Alexandra Hospital, Brisbane, Qld.
Ravenscroft
P J
PJ
Rigby
R J
RJ
D003524:Cyclosporins / Q000009:adverse effects / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D007654:Ketoconazole / Q000009:adverse effects* / Q000493:pharmacokinetics; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged
D003524:Cyclosporins; D007654:Ketoconazole