Transient diabetes insipidus of pregnancy.
Transient diabetes insipidus (DI) is a disease of late pregnancy, that has been reported with increasing frequency. Although initially thought to be nephrogenic, the etiology of this syndrome is most likely excess vasopressinase activity. The disease is associated with preeclampsia with liver involvement. Infants of mothers with the syndrome are predominantly male. Management may be with deamino D arginine vasopressin (dDAVP) during gestation and postpartum since vasopressinase does not break down dDAVP. The copious urine output may disguise preeclampsia. Fluid restriction should be avoided as it will lead to dehydration and hemoconcentration.
Krege
J
J
Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill.
Katz
V L
VL
Bowes
W A
WA
D000328:Adult; D010122:Cystinyl Aminopeptidase / Q000378:metabolism; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000201:enzymology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000503:physiopathology; D007231:Infant, Newborn; D008099:Liver / Q000503:physiopathology; D011141:Polyuria / Q000201:enzymology / Q000503:physiopathology; D011225:Pre-Eclampsia / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D013577:Syndrome
D010122:Cystinyl Aminopeptidase; D003894:Deamino Arginine Vasopressin