title: Use of antimicrobial agents in renal failure.
abstract: Many antimicrobial agents are excreted primarily by the kidneys, and hence, to avoid toxicity and maintain efficacy, dosage adjustments are necessary. After estimating a patient's creatinine clearance, an appropriate dosage adjustment is easily accomplished. The adjustments for aminoglycosides are simplified by the use of a suggested once-daily, or once every other day dosage regimen.
authors.affiliation: Oregon Health Sciences University, Portland.
authors.forename: D N
authors.initials: DN
authors.lastname: Gilbert
authors.forename: W M
authors.initials: WM
authors.lastname: Bennett
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000378:metabolism / Q000628:therapy; D008297:Male; D006435:Renal Dialysis
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003404:Creatinine