title: Incidence of reflux nephropathy (RN) in ESRD and effect of nephrectomy in RN on blood pressure and haematocrit following renal transplantation.
abstract: One hundred and fifty cases of end stage renal disease (ESRD) on pretransplant workup showed vesicoureteric reflux (VUR) in 21 (14%). Of these, 15 were primary reflux nephropathy (PRN) whereas 6 were secondary VUR. All patients in PRN group showed grade III to IV reflux while secondary VUR ranged between grade I to II. In the PRN group 38.5% had severe, 23% moderate and 23% mild hypertension; 53.3% were nonoliguric and 46.7% were oliguric. Mean plasma renin activity (PRA) was 6.6 and 2.85 ng/ml/hr in PRN and secondary VUR groups respectively. All cases of PRN and 2 from secondary VUR underwent nephrectomy and a month later renal transplantation. Following surgery blood pressure normalised without therapy in 50% and another 50% required lesser drugs in comparison to age matched non nephrectomised controls who showed hypertension in 100% cases, 60% requiring 3 to 4 drugs combination (p less than 0.05). Risk of low haematocrit in nephrectomised patients was insignificant.
authors.forename: S K
authors.initials: SK
authors.lastname: Agarwal
authors.forename: S C
authors.initials: SC
authors.lastname: Dash
authors.forename: K K
authors.initials: KK
authors.lastname: Malhotra
authors.forename: S C
authors.initials: SC
authors.lastname: Tiwari
authors.forename: S N
authors.initials: SN
authors.lastname: Mehta
authors.forename: I K
authors.initials: IK
authors.lastname: Dhawan
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications*; D000328:Adult; D001794:Blood Pressure; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D006400:Hematocrit; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D009392:Nephrectomy; D011704:Pyelonephritis / Q000150:complications*; D014718:Vesico-Ureteral Reflux / Q000150:complications*