A pragmatic approach to standard setting--the example of coal tar products and asphalt.
This article will outline a pragmatic approach directed to incorporating key elements of a scientific review of the literature and derive a proposal for an occupational exposure standard for coal tar, coal tar pitch, creosote, petroleum pitch, bitumen and asphalt, six substances which contain polynuclear aromatic hydrocarbons. Five approaches to the standard setting process are reviewed and their strengths and weaknesses discussed. Unfortunately there does not exist an acceptable epidemiological data set, other than the coke oven emission studies, on which to base a valid and reliable risk assessment model. Based on comparative potency experiments of complex mixtures, consideration of the state-of-the-art sampling and analytical methods, prevention of acute human health effects, and current existing standards for these substances throughout the world, a set of recommended exposure standards are derived for health policy makers.
Chong
J P
JP
Haines
A T
AT
Verma
D K
DK
D000818:Animals; D002273:Carcinogens / Q000009:adverse effects / Q000592:standards*; D003033:Coal Tar / Q000009:adverse effects / Q000592:standards*; D006801:Humans; D009784:Occupational Diseases / Q000139:chemically induced / Q000517:prevention & control*; D011083:Polycyclic Compounds / Q000009:adverse effects / Q000592:standards*
D002273:Carcinogens; D011083:Polycyclic Compounds; D003033:Coal Tar