title: Histiocytosis syndromes in children: II. Approach to the clinical and laboratory evaluation of children with Langerhans cell histiocytosis. Clinical Writing Group of the Histiocyte Society.
abstract: Langerhans cell histiocytosis (LCH) has presented problems in diagnosis and in treatment. The definitive diagnosis is a pathologic one. To advance thorough and uniform assessment of these patients, the elements of a complete clinical and laboratory evaluation are presented by the Histiocyte Society. Adoption of a uniform clinical/laboratory approach to these children, coupled with agreed-upon steps to the pathologic identification of LCH, should result in a better understanding and ultimately better and more rational therapies for the disease.
authors.affiliation: Department of Pediatrics, UCLA School of Medicine 90024.
authors.forename: V
authors.initials: V
authors.lastname: Broadbent
authors.forename: H
authors.initials: H
authors.lastname: Gadner
authors.forename: D M
authors.initials: DM
authors.lastname: Komp
authors.forename: S
authors.initials: S
authors.lastname: Ladisch
mesh_terms: D002648:Child; D002986:Clinical Trials as Topic; D005500:Follow-Up Studies; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006801:Humans