Molecular mechanisms of cutaneous aging. Age-associated connective tissue alterations in the dermis.
Clinically detectable, age-associated cutaneous changes result from two independent processes: chronologic aging and actinic irradiation. Several lines of evidence suggest that these two processes have different biologic, biochemical, and molecular mechanisms. This review summarizes the current understanding of age-associated alterations in the biochemistry and molecular biology of the extracellular matrix.
Uitto
J
J
Department of Dermatology, Jefferson Medical College, Philadelphia, PA 19107.
Fazio
M J
MJ
Olsen
D R
DR
D000368:Aged; D000375:Aging / Q000235:genetics / Q000473:pathology* / Q000502:physiology; D003094:Collagen / Q000096:biosynthesis; D004549:Elastin / Q000096:biosynthesis / Q000235:genetics / Q000648:ultrastructure; D006801:Humans; D012867:Skin / Q000648:ultrastructure*; D012879:Skin Physiological Phenomena; D014466:Ultraviolet Rays / Q000009:adverse effects*
D003094:Collagen; D004549:Elastin