title: Regulation of tetrahydrobiopterin synthesis during lectin stimulation of human peripheral blood lymphocytes.
abstract: Lectin stimulation of human T lymphocytes causes a 7-fold increase in the specific activities of GTP-cyclohydrolase and a 4-fold increase in the specific activities of sepiapterin reductase. GTP-cyclohydrolase activities are maximal after 48 h and subsequently decline, whereas sepiapterin reductase activities continue to increase during the 72 h period measured. The specific activities of 6-pyruvoyltetrahydropterin synthase remain unchanged upon stimulation. Tetrahydrobiopterin synthesis during blast transformation is thus directed by both GTP-cyclohydrolase and sepiapterin reductase.
authors.affiliation: GSF-Institut für Experimentelle Hämatologie, München, FRG.
authors.forename: F
authors.initials: F
authors.lastname: Kerler
authors.forename: I
authors.initials: I
authors.lastname: Ziegler
authors.forename: B
authors.initials: B
authors.lastname: Schwarzkopf
authors.forename: A
authors.initials: A
authors.lastname: Bacher
mesh_terms: D000429:Alcohol Oxidoreductases / Q000378:metabolism; D001708:Biopterins / Q000031:analogs & derivatives* / Q000096:biosynthesis; D055598:Chemical Phenomena; D002621:Chemistry; D006136:GTP Cyclohydrolase / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000494:pharmacology*; D019761:Phosphorus-Oxygen Lyases; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D037102:Lectins; D001708:Biopterins; D000429:Alcohol Oxidoreductases; C022630:sepiapterin reductase; D006136:GTP Cyclohydrolase; D019761:Phosphorus-Oxygen Lyases; C043497:6-pyruvoyltetrahydropterin synthase; C003402:sapropterin