[Clinical study on LRH-A contraception by luteolysis].
Thirty-eight healthy female volunteers, aged 26-38 years with regular menstrual cycles entered into a clinical trial for contraception with Chinese made superactive stimulatory analog of LRH i.e., (D-Ala, des-GLY-EA10)-LRH yielding luteolysis. LRH-A 1 mg a day was administered by intranasal spray from the 15th through 25th day of the menstrual cycle for 1-12 consecutive cycles. During LRH-A administration no additional contraceptive was used. Luteolysis refers to reduction in plasma progesterone and shortening of the luteal phase. The results showed that luteolysis occurred in 154/158 cycles, 4 pregnancies occurred due to faulty administration. No severe side-effects were observed during administration and apparently normal cycles occurred immediately after the withdrawal of LRH-A spray. The above data indicated that LRH-A may provide a fairly good luteolytic effect. More intensive study is required for clinical application in contraceptive practice.
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D000281:Administration, Intranasal; D003271:Contraceptive Agents, Female / Q000008:administration & dosage*; D003338:Corpus Luteum / Q000187:drug effects; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans
D003271:Contraceptive Agents, Female; D007987:Gonadotropin-Releasing Hormone; C050812:LHRH, Ala(6)-