Alcohol, cancer, and immunomodulation.
There is a great deal of epidemiological evidence indicating that chronic, excessive alcohol consumption is a major risk factor for cancers in humans. However, the experimental basis for the increased cancer risk associated with alcohol intake is not clear. Since it appears that ethanol alone is not carcinogenic, ethanol effects must be explained in terms of its modifying the actions of other causal agents. Current studies indicate that ethanol and its congeners may act as tumor promoters, thereby enhancing the effect of initiating carcinogens from the environment. Available evidence also shows that ethanol is immunosuppressive. Clearly, cirrhosis due to high, prolonged alcohol intake is an indicator of the immunosuppressive effects of ethanol. It is less clear that more moderate intakes of alcohol could have as profound an effect on immune systems. However, changes do occur yielding alterations in lymphocyte sensitivity to alcohol in vitro and in cell development, as shown by increased NK cell function at low concentrations. Since other conditions, such as cytotoxic drugs which suppress cellular immune functions, are clearly associated with increased cancer risk. It is intriguing to think that prolonged exposure to ethanol-induced immunosuppression may be a cofactor in the promotion of cancer. The tumor promotion may take place via a variety of mechanisms as discussed in this paper, including reduced host defenses by direct effects of ethanol, its metabolites, and/or malnutrition. It may be beneficial to test methods for immunostimulation in prolonged alcohol abusers, where cessation of use is unsuccessful or residual immunosuppression remains, to reduce the risk of development or growth of initiated tumors.
Mufti
S I
SI
Department of Pharmacology-Toxicology, College of Pharmacy, University of Arizona, Tucson 85724.
Darban
H R
HR
Watson
R R
RR
D000437:Alcoholism / Q000150:complications* / Q000276:immunology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003043:Cocarcinogenesis; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D051379:Mice; D009369:Neoplasms / Q000139:chemically induced / Q000209:etiology*; D051381:Rats
D000431:Ethanol