title: Indium-111-labeled platelets in monitoring human pancreatic transplants.
abstract: We have performed 59 111In-labeled platelet scintigraphies in 12 patients with pancreas transplant, and we have compared retrospectively the 111In platelet uptake with the graft immunological situation. A diffuse uptake in the graft was seen in five of six patients with pancreatic rejection. The scans became positive before changes in biochemical tests were detected. No 111In platelet uptake was seen in five of seven normally functioning grafts. Two cases of venous thrombosis and two perigraft hematomas appeared like a focal 111In platelet accumulation. Indium-111-labeled platelet scintigraphy can be a useful method for monitoring pancreas transplants. It may be helpful in the early detection of pancreatic allograft rejection and in the differential diagnosis between this and other complications such as thrombosis or hematomas.
authors.affiliation: Nuclear Medicine Service, Hospital Clinic i Provincial, Barcelona, Spain.
authors.forename: A M
authors.initials: AM
authors.lastname: Catafau
authors.forename: F J
authors.initials: FJ
authors.lastname: Lomeña
authors.forename: M J
authors.initials: MJ
authors.lastname: Ricart
authors.forename: F
authors.initials: F
authors.lastname: Pons
authors.forename: C
authors.initials: C
authors.lastname: Piera
authors.forename: J
authors.initials: J
authors.lastname: Pavía
authors.forename: M
authors.initials: M
authors.lastname: Moragas
authors.forename: A
authors.initials: A
authors.lastname: Garcia
authors.forename: R
authors.initials: R
authors.lastname: Herranz
authors.forename: J
authors.initials: J
authors.lastname: Andreu
mesh_terms: D000328:Adult; D001792:Blood Platelets; D003920:Diabetes Mellitus / Q000601:surgery; D003928:Diabetic Nephropathies / Q000601:surgery; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007205:Indium Radioisotopes; D007668:Kidney / Q000000981:diagnostic imaging / Q000276:immunology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D010179:Pancreas / Q000000981:diagnostic imaging / Q000276:immunology; D016035:Pancreas Transplantation; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging
chemical_list: D007205:Indium Radioisotopes