Binding of drugs to alpha 1-acid glycoprotein and its desialylated form. Influence on hepatic disposition and implications for drug targeting to the liver.
Meijer
D K
DK
Department of Pharmacology and Therapeutics, University Center of Pharmacy, Groningen, The Netherlands.
van der Sluijs
P
P
D000818:Animals; D037263:Asialoglycoprotein Receptor; D004705:Endocytosis / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D019158:N-Acetylneuraminic Acid; D009961:Orosomucoid / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D011971:Receptors, Immunologic / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D012794:Sialic Acids / Q000378:metabolism
D037263:Asialoglycoprotein Receptor; D009961:Orosomucoid; D004364:Pharmaceutical Preparations; D011971:Receptors, Immunologic; D012709:Serum Albumin; D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid