title: The utility of the panic disorder concept.
abstract: In this paper we discuss the theory that agoraphobic avoidances are central and spontaneous panics an epiphenomenon to the development of agoraphobia. Moreover we discuss the theory that posits a fixed cognitive-catastrophizing set as causal for panic. We conclude these theories do not fit the facts. We argue that it is important to distinguish between spontaneous panic and chronic or anticipatory anxiety and avoidance. Such a distinction allows for an understanding of the roles of anti-spontaneous panic medications such as tricyclics and MAOI's as well as exposure therapy, in the treatment of panic disorder with agoraphobia. The former serves the purpose of blocking panic attacks while the latter undermines phobic avoidance, but only after the panic attacks have ceased through proper medication. We conclude that recognizing the key role of spontaneous panic and its variants in anxiety nosology is a necessary guide for etiological, psychophysiological and therapeutic research in this rapidly developing area.
authors.affiliation: Department of Psychiatry, Columbia University College of Physicans and Surgeons, New York, NY.
authors.forename: D F
authors.initials: DF
authors.lastname: Klein
authors.forename: H M
authors.initials: HM
authors.lastname: Klein
mesh_terms: D000379:Agoraphobia / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000175:diagnosis / Q000503:physiopathology; D003937:Diagnosis, Differential; D006801:Humans; D010698:Phobic Disorders / Q000503:physiopathology*
chemical_list: D000928:Antidepressive Agents