What is the relationship between the endothelium derived relaxant factor and nitric oxide?
Nitric oxide gas in solution (NO) relaxes blood vessels with similar actions and pharmacodynamics as the endothelium derived relaxant factor (EDRF) and has been proposed to be a component of the materials released from stimulated endothelial cells. Certain data however suggest that EDRF and NO may not be identical. In some non-vascular smooth muscles, NO and EDRF exhibit markedly different pharmacologic profiles. Furthermore the interaction of EDRF and NO with anion exchange resins differ. The hypothesis that EDRF is identical to nitric oxide gas in solution or a nitrogen oxide containing compound is discussed.
Long
C J
CJ
Department of Pharmacology, Smith Kline and French Laboratories, King of Prussia, PA 19406-2799.
Berkowitz
B A
BA
D000818:Animals; D001685:Biological Factors / Q000032:analysis / Q000378:metabolism* / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009569:Nitric Oxide / Q000032:analysis / Q000378:metabolism* / Q000494:pharmacology
D001685:Biological Factors; D009569:Nitric Oxide