Antibodies to 'second colloid antigen.' A study on the prevalence in sporadic forms of congenital hypothyroidism.
Antibodies against the so called 'second colloid antigen' (CA2 antibodies) occurred in 51% of the mothers of hypothyroid children detected by screening for neonatal congenital hypothyroidism in Quebec (N = 49) and in The Netherlands (N = 26). In The Netherlands where corresponding neonatal serum was available, 31% (8 of 26) of the infants with congenital hypothyroidism were positive for antibodies against the second colloid antigen. When during follow-up, 3 to 5 years after diagnosis, the mothers and their children were investigated, 46% (7 of 15) of the mothers were positive for antibodies against the second colloid antigen, whereas 29% (4 of 14) of the hypothyroid children were also positive. Various control groups did not show more than a 12% positivity. This presence of thyroid-reactive antibodies in a proportion of the hypothyroid children 3 to 5 years after diagnosis is not compatible with a mere transplacental passage; it indicates that the antibodies must be produced by the mothers and by the children themselves. We conclude that a thyroid autoimmune response occurs in a considerable part of infants with congenital hypothyroidism and their mothers and that this immune response seems to persist in both of them for years.
van Trotsenburg
P
P
Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
Vulsma
T
T
Bloot
A M
AM
Van der Gaag
R D
RD
Lens
J W
JW
Drexhage
H A
HA
de Vijlder
J J
JJ
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003409:Congenital Hypothyroidism; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007037:Hypothyroidism / Q000453:epidemiology / Q000276:immunology; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D011792:Quebec / Q000453:epidemiology; D013954:Thyroglobulin / Q000276:immunology; D013968:Thyroiditis, Subacute / Q000276:immunology
D000906:Antibodies; D001323:Autoantibodies; D013954:Thyroglobulin