Biochemistry of nonheme iron in man. II. Absorption of iron.
The currently accepted concept of iron absorption proposes first the entry of iron into the intestinal mucosal cell through the brush border membrane. It is a relatively slow process. In the cell, the iron may be transferred to plasma or become sequestered by ferritin. The latter becomes unavailable for transfer to plasma and is exfoliated and excreted. In iron deficiency and idiopathic hemochromatosis, the rate of iron uptake into the intestinal mucosal cell is increased and entry into ferritin is decreased, whereas the rate of transfer to plasma remains constant. The reverse occurs in case of secondary iron overload. It is currently accepted that a transferrin, whose levels increase in iron deficiency, enters the intestinal lumen from the liver via bile, where it may sequester iron and bring it into the cells by the process of endocytosis. Iron presented as inorganic ferric or ferrous salts may also be absorbed, though the more soluble ferrous salts are adsorbed much more rapidly. Heme iron is absorbed very effectively, though it is not subject to regulation by the individual's iron status to the same extent as is inorganic iron absorption. Brush border membranes apparently contain saturable iron receptors for inorganic iron, but whether or not the absorption process requires energy is an open question. Absorption of iron may also be affected by its availability; different food components affect iron absorbability to a different extent.
Bezkorovainy
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Department of Biochemistry, Rush Presbyterian-St. Luke's Medical Center, Chicago, Ill.
D000818:Animals; D004285:Dogs; D005260:Female; D005290:Ferric Compounds / Q000378:metabolism; D005293:Ferritins / Q000378:metabolism; D005296:Ferrous Compounds / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D011247:Pregnancy; D014168:Transferrin / Q000378:metabolism
D005290:Ferric Compounds; D005296:Ferrous Compounds; D014168:Transferrin; D005293:Ferritins; D007501:Iron