title: [Prenatal diagnosis of premature closure of the ductus arteriosus with subsequent development of a non-immunologic hydrops fetalis].
abstract: The premature closure of the ductus arteriosus (pcDA) due to maternal tocolysis with indomethacin in the 34th week of gestation was diagnosed in a twin pregnancy. The pcDA was detected using Doppler 24 hours before both fetuses developed pleural effusion. Pathologic waveforms in the fetal aorta with end-diastolic zero-flow were registered. A no-delay caesarean section with optimal neonatologic intensive care were successful for the survival of the neonates. The authors postulate, that the amount of pcDA as a cause of NIHF is higher than generally supposed. Furthermore a tocolysis with indomethacin should not be performed after the 34th week of gestation.
authors.affiliation: Klinik und Poliklinik für Gynäkologie und Geburtshilfe des Bereichs Medizin (Charité) Humboldt-Universität zu Berlin.
authors.forename: R
authors.initials: R
authors.lastname: Chaoui
authors.forename: H
authors.initials: H
authors.lastname: Hoffmann
authors.forename: R
authors.initials: R
authors.lastname: Bollmann
authors.forename: R
authors.initials: R
authors.lastname: Wauer
mesh_terms: D000328:Adult; D002585:Cesarean Section; D003251:Constriction, Pathologic / Q000139:chemically induced; D004373:Ductus Arteriosus / Q000187:drug effects*; D005260:Female; D006801:Humans; D015160:Hydrops Fetalis / Q000139:chemically induced* / Q000175:diagnosis; D007213:Indomethacin / Q000008:administration & dosage / Q000009:adverse effects*; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D011272:Pregnancy, Multiple / Q000187:drug effects*; D011296:Prenatal Diagnosis; D015145:Tocolysis; D014463:Ultrasonography
chemical_list: D007213:Indomethacin
vernacular_title: Pränatale Diagnose eines vorzeitigen Verschlusses des Ductus arteriosus mit nachfolgender Entwicklung eines nichtimmunologischen Hydrops fetalis (NIHF).