title: A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer.
abstract: Epidemiological and experimental evidence indicates that oestrogens are involved in the carcinogenic promotion of human breast cancer. We have undertaken a pilot trial of tamoxifen, an anti-oestrogen, compared to placebo given to 200 women at a high risk of developing breast cancer. The results of this trial show that acute toxicity is low and that accrual and compliance are satisfactory. Furthermore, biochemical monitoring of lipids and clotting factors indicate that tamoxifen may reduce the risk of cardiovascular deaths. At this stage no untoward long-term risks have been identified, and it is therefore proposed that a large multicentre trial should be started.
authors.affiliation: Royal Marsden Hospital, Sutton, Surrey, UK.
authors.forename: T J
authors.initials: TJ
authors.lastname: Powles
authors.forename: J R
authors.initials: JR
authors.lastname: Hardy
authors.forename: S E
authors.initials: SE
authors.lastname: Ashley
authors.forename: G M
authors.initials: GM
authors.lastname: Farrington
authors.forename: D
authors.initials: D
authors.lastname: Cosgrove
authors.forename: J B
authors.initials: JB
authors.lastname: Davey
authors.forename: M
authors.initials: M
authors.lastname: Dowsett
authors.forename: J A
authors.initials: JA
authors.lastname: McKinna
authors.forename: A G
authors.initials: AG
authors.lastname: Nash
authors.forename: H D
authors.initials: HD
authors.lastname: Sinnett
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D013629:Tamoxifen / Q000627:therapeutic use* / Q000633:toxicity
chemical_list: D013629:Tamoxifen