Positional signalling and patterning for amelogenesis in mouse molar tooth development.
Oral mandibular epithelium determines the position and number of tooth organs. Cranial neural crest-derived ectomesenchyme provides inductive signals for (i) tooth shape, and (ii) sequential determination and expression of several different epithelial-derived enamel proteins. Inductive signalling follows a precise sequence, can be expressed in serumless, chemically-defined medium in vitro, and appears to be highly conserved during vertebrate evolution.
Slavkin
H C
HC
Department of Basic Sciences (Biochemistry), School of Dentistry, University of Southern California, Los Angeles 90089-0191.
D000566:Amelogenesis / Q000502:physiology*; D000818:Animals; D003746:Dental Enamel Proteins / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression / Q000502:physiology; D051379:Mice; D008963:Molar / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*; D009805:Odontogenesis / Q000502:physiology*
D003746:Dental Enamel Proteins