Poor response to long-term albendazole therapy of hydatid liver cysts.
Seven patients with uncomplicated hepatic hydatid cysts (Echinococcus granulosus) were treated with albendazole 10 mg/kg/day for 2-6 months (mean 4 months). Serial sonographic evaluation showed reduction in cyst size in only 1 patient (the anteroposterior diameter decreased from 16.5 cm to 4.9 cm). Therapy in this patient was discontinued after 4 months due to development of jaundice. Albendazole appears to have a limited role in the treatment of hydatid disease of the liver.
Choudhuri
G
G
Department of Gastroenterology, Indira Gandhi Institute of Medical Sciences, Patna, India.
Prasad
R
R
Tantry
B V
BV
Sharma
M P
MP
Tandon
R K
RK
D000328:Adult; D015766:Albendazole; D000871:Anthelmintics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D004444:Echinococcosis, Hepatic / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography
D000871:Anthelmintics; D001562:Benzimidazoles; D015766:Albendazole