[Does immunoscintigraphy improve early diagnosis of metastatic or recurrent cancer?].
In 42 patients with suspicion of recurrent colorectal cancer results of conventional diagnostic methods were compared to those of immunoscintigraphy. In 69% of all cases the intraoperative findings of a second-look operation served for validation, in 31% the follow-up was controlled. Localization of recurrent tumors was successful in 83% using conventional methods versus 57% by immunoscintigraphy. This procedure disappointed especially by a low sensitivity (23%) and low predictive parameters (pos.: 33%; neg.: 37%) in regard to diagnosis of extrahepatic tumors compared to results of conventional methods (77%), 94% respectively 79%). The quote of false positive results was surprisingly high in immunoscintigraphy (n = 12), 83% of these especially in localization of extrahepatic tumors. Therefore, the validity of immunoscintigraphy as an additive diagnostic tool for early detection of recurrent colorectal cancer must be regarded critically.
Hölting
T
T
Sektion für Chir. Onkologie, Universitätsklinik Heidelberg.
Steinbächer
M
M
Kretzschmar
U
U
Georgi
P
P
Schlag
P
P
D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D006801:Humans; D007457:Iodine Radioisotopes; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000601:surgery; D011877:Radionuclide Imaging; D012086:Reoperation
D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen; D007457:Iodine Radioisotopes
Verbessert die Immunszintigraphie die Frühdiagnostik des metastasierten oder rezidivierten Karzinoms?