[The effect of intravenous administration of butyrate, isobutyrate and isovalerate to lambs aged 8-45 days on the blood plasma content of glucose, insulin, free fatty acids and total alpha-amino-N].
Massive dose injections of butyrate, isobutyrate, and isovalerate (1.25 mmol/kg body weight) as well as of physiological saline solutions were applied to 4 groups of lambs aged 8 to 15, 16 to 22, 23 to 29, and 30 to 45 days. Blood samples were drawn prior to infusion as well as 5, 15, 30, 60, 90, 120, and 180 minutes from mid-infusion. Original glucose and insulin levels in the blood plasma of 87 lambs had been 5.24 +/- 0.85 mmol/l or 191 +/- 106 pmol/l, respectively. Infusion of these solutions led to temporary rise in blood plasma levels of glucose, insulin, and free fatty acids. The highest insulin level increase resulted from isovalerate infusion. Total alpha amino nitrogen in blood plasma went down. It appeared to be obvious that lambs, even before their forestomachs came into action, responded to infusion of volatile fatty acids by increase in insulin secretion.
Düsedau
K
K
Kolb
E
E
Müller
I
I
Lippmann
R
R
Vallentin
G
G
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002087:Butyrates / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005232:Fatty Acids, Volatile / Q000494:pharmacology*; D045782:Hemiterpenes; D007328:Insulin / Q000097:blood*; D058610:Isobutyrates; D009584:Nitrogen / Q000097:blood*; D010421:Pentanoic Acids / Q000494:pharmacology; D012756:Sheep / Q000097:blood*
D001786:Blood Glucose; D002087:Butyrates; D005230:Fatty Acids, Nonesterified; D005232:Fatty Acids, Volatile; D045782:Hemiterpenes; D007328:Insulin; D058610:Isobutyrates; D010421:Pentanoic Acids; C008216:isovaleric acid; C020380:isobutyric acid; D009584:Nitrogen
Untersuchungen über den Einfluss der intravenösen Verabreichung von Butyrat, Isobutyrat und Isovalerat bei Lämmern im Alter von 8-45 Tagen auf den Gehalt des Blutplasmas an Glucose, Insulin, freien Fettsäuren und Gesamt-alpha-Amino-N.