Jaundice as a paraneoplastic phenomenon in a T-cell lymphoma.
An adolescent male developed severe unexplained cholestatic jaundice 3 mo before diagnosis of mediastinal non-Hodgkin's lymphoma (T-cell, late thymic phenotype). There was no anatomic obstruction to bile flow, no evidence for an infectious etiology, and no neoplastic involvement of the liver or bile ducts. A paraneoplastic phenomenon is postulated because the jaundice resolved after treatment of the lymphoma. We suggest that occult lymphoma must be added to the differential diagnosis of unexplained intrahepatic cholestasis.
Watterson
J
J
Department of Hematology/Oncology, Children's Hospital of St. Paul, Minnesota.
Priest
J R
JR
D000293:Adolescent; D002780:Cholestasis, Intrahepatic / Q000209:etiology*; D003937:Diagnosis, Differential; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications*; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D013601:T-Lymphocytes