The tumor-associated antigens BR55-2, GA73-3 and GICA 19-9 in normal and corresponding neoplastic human tissues, especially gastrointestinal tissues.
Immunohistochemical analysis with a monoclonal antibody, anti-BR55-2, was carried out on 163 tumors with their adjacent normal tissues and on 51 normal tissues from various organs by the ABC method. The expression of the antigen BR55-2 was compared with the expression of the colorectal carcinoma (CRC) associated antigens, GA73-3 and GICA19-9. BR55-2 was expressed in most normal epithelial tissues, whereas in the colon it seems to be exclusively a tumor-associated antigen. MAb55-2 might be of value in studying dysplastic lesions of the colon and in assessing the depth of invasion of CRC. In CRC, the expression of BR55-2 was complementary to that of GA73-3. MAb55-2 may therefore be of value in immunotherapy of CRC.
Shetye
J
J
Department of Pathology, Karolinska Hospital, Stockholm, Sweden.
Christensson
B
B
Rubio
C
C
Rodensjö
M
M
Biberfeld
P
P
Mellstedt
H
H
D000911:Antibodies, Monoclonal / Q000276:immunology; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis; D002454:Cell Differentiation; D004064:Digestive System / Q000276:immunology*; D005770:Gastrointestinal Neoplasms / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007983:Lewis Blood Group Antigens / Q000276:immunology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D007983:Lewis Blood Group Antigens