Genetic polymorphisms of drug metabolism. Possible implications during development.
Genetic polymorphisms of drug metabolism can affect phase I and phase II reactions. Polymorphisms of cytochrome P450 activity or inducibility have been implicated in drug toxicity and in cancerogenesis. Polymorphisms of the detoxification processes may be important in the appearance of adverse responses to conventional doses of drugs. Pharmacogenetics now opens new ways to investigate the relations between genetic factors, xenobiotics and teratogenesis.
Jacqz-Aigrain
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INSERM U120, Le Vésinet, France.
D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D006801:Humans; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011110:Polymorphism, Genetic
D004364:Pharmaceutical Preparations