Imaging the hamster flank organ by an ultrasonic technique: a new approach to animal tests.
Images of the hamster flank organ were obtained in vivo by high resolution ultrasound (B-scan). The planimetric measurements of the ultrasonic image that determined the size of the flank organ, with a reproducibility of about 10%, highly correlated with the measurements of histological sections. This new method provides a simple and non-invasive method for determining the size of the hamster flank organ after various treatments which does not involve the killing of the animal under investigation.
Combettes
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Laboratoire de Recherches de L'Oreal, Departement de Biophysique, Aulnay-sous-Bois, France.
Durand-Seme
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V
Querleux
B
B
Saint-Leger
D
D
Leveque
J L
JL
D000818:Animals; D006224:Cricetinae; D003534:Cyproterone / Q000494:pharmacology; D005260:Female; D005485:Flutamide / Q000494:pharmacology; D008297:Male; D008647:Mesocricetus; D009919:Orchiectomy; D012627:Sebaceous Glands / Q000033:anatomy & histology* / Q000187:drug effects; D012867:Skin / Q000033:anatomy & histology*; D013148:Spironolactone / Q000494:pharmacology; D013739:Testosterone / Q000494:pharmacology; D014463:Ultrasonography / Q000379:methods*
D013148:Spironolactone; D013739:Testosterone; D005485:Flutamide; D003534:Cyproterone