A case of bullous pemphigoid induced by tiobutarit (D-penicillamine analogue).
A 61-year-old woman with severe rheumatoid arthritis developed bullous lesions on the trunk, conjunctiva, and oral mucosa during treatment with tiobutarit, a new antirheumatic drug analogus to D-penicillamine. Histology showed a subepidermal blister, and circulating antibodies to the basement membrane zone were detected. The bullous lesions improved rapidly after discontinuation of tiobutarit. However, 3 years later, she was re-exposed to tiobutarit and the bullous lesions recurred within a week. This is the first confirmed case of tiobutarit-induced BP.
Yamaguchi
R
R
Oryu
F
F
Hidano
A
A
D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003545:Cysteine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010391:Pemphigoid, Bullous / Q000139:chemically induced* / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*
D000893:Anti-Inflammatory Agents; D003545:Cysteine; C026535:bucillamine