Mapping minor H genes.
The manner in which minor histocompatibility (H) antigens have been defined in mouse and man, in vivo and in vitro, is considered. Chromosomal mapping of minor H genes using T-cell clones is illustrated, with particular reference to the H-Y antigen gene, using the sex-reversing translocation Sxr of mouse and the Sxr' mutation derived from it. A number of minor H antigen-specific T-cell clones restricted by class I or class II major histocompatibility complex (MHC) molecules are described, together with information about their phenotypes and T-cell receptor usage.
Simpson
E
E
MRC Clinical Research Centre, Transplantation Biology Section, Harrow, Middlesex, U.K.
Tomonari
K
K
D000818:Animals; D002874:Chromosome Mapping; D006801:Humans; D051379:Mice; D008912:Minor Histocompatibility Loci