Spinal epidural lipomatosis: a serious complication of iatrogenic Cushing's syndrome.
Our experience and review of the literature demonstrate that spinal epidural lipomatosis is a rare but serious neurologic complication of iatrogenic Cushing's syndrome. Most patients develop slowly progressive paraparesis over months, but a subgroup exists which presents with acute, irreversible paraplegia. We consider therapeutic options.
Kaplan
J G
JG
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461.
Barasch
E
E
Hirschfeld
A
A
Ross
L
L
Einberg
K
K
Gordon
M
M
D000293:Adolescent; D000328:Adult; D003480:Cushing Syndrome / Q000139:chemically induced* / Q000150:complications; D004824:Epidural Space; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007049:Iatrogenic Disease; D007796:Laminectomy; D008068:Lipomatosis / Q000150:complications / Q000209:etiology* / Q000601:surgery; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects; D008875:Middle Aged; D010264:Paraplegia / Q000209:etiology; D011241:Prednisone / Q000009:adverse effects; D013125:Spinal Neoplasms / Q000150:complications / Q000209:etiology* / Q000601:surgery
D005938:Glucocorticoids; D011241:Prednisone; D008775:Methylprednisolone