Effect of endothelin on systemic and regional hemodynamics in rats.
In this study we analyzed the changes in systemic haemodynamics induced by endothelin, 1 nmol/kg, given as an i.v. bolus to anaesthetized rats. Endothelin induced a dramatic decrease in cardiac output whereas the total peripheral resistance increased more than two times. In addition, renal blood flow decreased while renal vascular resistance increased to a similar extent. A marked decrease in blood flow to the splanchnic organs was also observed. In conclusion, endothelin seems to modulate peripheral vasomotor tone, at least under certain conditions.
Ais
G
G
Renal Physiopathology Laboratory, Fundación Jiménez Díaz-Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Novo
C
C
López-Farré
A
A
Romeo
J M
JM
López-Novoa
J M
JM
D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D016232:Endothelins; D006439:Hemodynamics / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D016232:Endothelins; D010455:Peptides