Interconversion of polyamines in wild-type strains and mutants of yeasts and the effects of polyamines on their growth.
Yeasts of wild-type strains, such as Saccharomyces cerevisiae, Schizosaccharomyces pombe and Candida albicans were shown to have the ability to form aminopropylcadaverine and aminopropylhomospermidine from cadaverine and homospermidine, respectively. A polyamine autotroph S. cerevisiae 179-5, which lacks ornithine decarboxylase, produced both aminopropylcadaverine and aminopropylhomospermidine, while another mutant S. cerevisiae Y 260 A, which lacks spermine synthase, formed only aminopropylcadaverine. Naturally-occurring triamines and tetraamines except norspermidine and norspermine stimulated the growth of S. cerevisiae 179-5. All the six aliphatic diamines with carbon chain length ranging from one to six were effective in activating the growth of S. cerevisiae 179-5, though all of them were not converted to either triamines or tetraamines.
Hamana
K
K
College of Medical Care and Technology, Gunma University, Maebashi, Japan.
Matsuzaki
S
S
Hosaka
K
K
Yamashita
S
S
D002176:Candida albicans / Q000187:drug effects / Q000235:genetics / Q000254:growth & development*; D002851:Chromatography, High Pressure Liquid; D009154:Mutation; D011073:Polyamines / Q000032:analysis / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics / Q000254:growth & development*; D004718:Saccharomycetales / Q000254:growth & development*; D012568:Schizosaccharomyces / Q000187:drug effects / Q000235:genetics / Q000254:growth & development*
D011073:Polyamines