[Clinical significance of cerebrospinal fluid beta 2-microglobulin determination in central nervous system leukemia].
Cerebrospinal fluid (CSF) beta 2-microglobulin (beta 2-MG) level was measured in 72 healthy subjects and the value (means +/- S means) was found to be 1.26 +/- 0.06 mg/L. The CSF beta 2-MG level in 33 patients who had simple acute leukemia without CNS involvement was 1.46 +/- 0.13 mg/L, which was not significantly different from that in the normal controls (P greater than 0.05). In 25 patients who had leukemia with involvement of CNS, the CSF beta 2-MG level (mean +/- S mean) was 3.94 +/- 0.30 mg/L, which was statistically different from that in the healthy controls (P less than 0.01). It is found that beta 2-MG level in CSF was one of the reliable criteria for diagnosis and indication of intrathecal chemotherapy in CNS leukemia.
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D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000134:cerebrospinal fluid*; D008297:Male; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000134:cerebrospinal fluid*; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid*
D001613:beta 2-Microglobulin