Prevention of Salmonella typhimurium colonization of broilers with D-mannose.
Broiler chickens can be contaminated by Salmonella typhimurium, which is a food safety concern. It has been previously shown that D-mannose blocks S. typhimurium adherence to chicken intestine in vitro. One-day-old broiler chickens were fed normal drinking water or drinking water supplemented with 2.5% mannose for 10 days. On Day 3, both groups were challenged orally with 1 x 10(8) S. typhimurium [ST-10 (Animal Diagnostics Laboratory, Ames, IA)] resistant to Nal and Nov (Sigma, St. Louis, MO). On Day 10 the birds' caecal contents were examined for the antibiotic-marked S. typhimurium. Two additional groups of birds were provided normal drinking water or mannose but were not challenged with the bacteria. Salmonella-challenged control chickens were 78, 82, and 93% colonized whereas Salmonella-challenged mannose-treated chickens were only 28, 21, and 43% colonized. Moreover, the mean log10 counts of control and mannose groups were significantly (P less than .001) reduced by at least 99%. Mannose-supplemented drinking water had no effect on weight gains. Certain carbohydrates may provide a means to reduce S. typhimurium contamination in broilers.
Oyofo
B A
BA
U.S. Department of Agriculture, Veterinary Toxicology and Entomology Research Laboratory, College Station, Texas 77840.
DeLoach
J R
JR
Corrier
D E
DE
Norman
J O
JO
Ziprin
R L
RL
Mollenhauer
H H
HH
D000284:Administration, Oral; D000818:Animals; D002432:Cecum / Q000382:microbiology; D002645:Chickens; D004326:Drinking; D008297:Male; D008358:Mannose / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000517:prevention & control*; D012481:Salmonella Infections, Animal / Q000517:prevention & control*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000254:growth & development; D015430:Weight Gain
D008358:Mannose