Immunolocalisation of aspartic proteinases in the developing human stomach.
The distribution and time of appearance in the developing human stomach of the 4 aspartic proteinases, pepsinogen, progastricsin, slow-moving protease and cathepsin D, all present in gastric carcinoma, has been determined by the peroxidase-antiperoxidase method on formalin fixed paraffin embedded sections of fetal stomach. Slow-moving protease appears to be the dominant enzyme from 12 weeks gestation onward, although progastricsin is also present at this time. Pepsinogen and cathepsin D do not appear until 17-18 weeks.
Reid
W A
WA
Department of Pathology, University of Leeds, UK.
McGechaen
K
K
Branch
T
T
Gray
H D
HD
Thompson
W D
WD
Kay
J
J
D016282:Aspartic Acid Endopeptidases; D002402:Cathepsin D / Q000032:analysis; D010450:Endopeptidases / Q000378:metabolism*; D004847:Epithelial Cells; D005753:Gastric Mucosa / Q000166:cytology; D005755:Gastrins / Q000032:analysis; D005865:Gestational Age; D006801:Humans; D007124:Immunoenzyme Techniques; D010435:Pepsinogens / Q000032:analysis; D011498:Protein Precursors / Q000032:analysis; D013270:Stomach / Q000166:cytology / Q000196:embryology*
D005755:Gastrins; D010435:Pepsinogens; D011498:Protein Precursors; C013706:big gastrin; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; D002402:Cathepsin D