Effect of endothelin-1 on release of arginine-vasopressin from perifused rat hypothalamus.
Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide with potent pressor activity. We studied the effect of ET-1 on release of arginine-vasopressin (AVP) from perifused rat hypothalamus. ET-1 (10(-10) to 10(-8) M) significantly stimulated AVP release. The ET-1-induced AVP release was completely blocked in the presence of nicardipine. Our results suggest a possible involvement of ET in the regulation of AVP release.
Shichiri
M
M
Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Hirata
Y
Y
Kanno
K
K
Ohta
K
K
Emori
T
T
Marumo
F
F
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D016232:Endothelins; D004730:Endothelium, Vascular / Q000502:physiology; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D016232:Endothelins; D010455:Peptides; D001127:Arginine Vasopressin