[Bacteriological investigation on an outbreak of acute enteritis associated with verotoxin-producing Escherichia coli O111:H-].
An outbreak of acute enteritis in children aged one to thirty-three months occurred from June 10th to 23rd, 1986, at a private orphanage in Matsuyama City. Twenty-two out of 23 children suffered from diarrhea. Nine of the 22 children excreted bloody stool. Fever and vomiting were observed with a few patients. One of them, a 33-month-old girl, developed hemolytic uremic syndrome, and died twelve days after the admission. Escherichia coli O111:H- was isolated from fecal specimens of 7 out of 15 patients. The culture filtrate of the isolate caused fluid accumulation in ligated ileal loops in a rabbit, and was lethal to mice. It was found that all isolates produced two kinds of Vero toxins (VT1 and VT2, or shiga-like toxin I and II). The amount of VT2 produced in vitro was about 10 times more than that of VT1.
Tanaka
H
H
Ohseto
M
M
Yamashita
Y
Y
Shinohara
N
N
Inoue
H
H
Sasaki
Y
Y
Kakihara
Y
Y
Tsukamoto
T
T
Yutsudo
T
T
Oku
Y
Y
D000208:Acute Disease; D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis* / Q000276:immunology / Q000633:toxicity; D002675:Child, Preschool; D004196:Disease Outbreaks; D004751:Enteritis / Q000453:epidemiology / Q000209:etiology*; D004926:Escherichia coli / Q000378:metabolism*; D004927:Escherichia coli Infections; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D051379:Mice; D011817:Rabbits; D022622:Shiga Toxin 1
D001427:Bacterial Toxins; D022622:Shiga Toxin 1