[Quantitative estimation of pancreatic islet cells in diabetes mellitus].
Pancreatic tissues from 40 autopsies of diabetes mellitus and 10 surgically resected non-diabetic pancreatic specimens were studied morphologically and immunocytochemically. Slides were stained for insulin(B), glucagon(A), somatostatin(D), and pancreatic polypeptide (PP) producing cells using immunocytochemistry. Morphometric study disclosed a significant decrease in the number of B-cells and a relative increase in the number of A cells, the A/B ratio shifted from 1:2.3 in controls to 1:0.9 in diabetics. No significant change was found in the number of D and PP cells in diabetics as compared with those in controls. The results of this study have further proved the presence of B cell reduction in diabetic patients.
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007328:Insulin / Q000032:analysis; D007515:Islets of Langerhans / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D007328:Insulin