Etiologic factors in renovascular fibromuscular dysplasia. A case-control study.
The role of several factors that have been suggested as being of etiologic importance in renovascular fibromuscular dysplasia was examined in a case-control study of 33 patients with angiographically demonstrated fibromuscular dysplasia and 61 renal transplant donor control subjects with normal renal arteries. The factors studied included use of oral contraceptive agents or markers of sex hormone dysfunction, mechanical stress to the renal artery wall, human lymphocytic antigen (HLA) type, cigarette smoking, history of hypertension for more than 5 years, and family history of cardiovascular disease. The risk of fibromuscular dysplasia was significantly (p = 0.003) increased (odds ratio = 4.1, 95% confidence interval = 1.5-10.9) among cigarette smokers. A significant (p less than 0.001) dose-response relation was noted between cigarette use and the risk of fibromuscular dysplasia developing (odds ratio = 8.6 for those who had smoked more than 10 pack-years). Personal history of hypertension more than 5 years was also associated (odds ratio = 5.0, 95% confidence interval = 1.1-22.8) with a significantly (p = 0.036) increased risk for the development of fibromuscular dysplasia. HLA-DRw6 antigen was more common in the 33 fibromuscular dysplasia patients than in the 61 renal transplant donor control subjects (odds ratio = 3.00, p = 0.067) or a second group of 934 ambulatory control subjects (odds ratio = 2.51, p = 0.031). Adjustment for cigarette smoking increased the odds ratio to 5.0 (95% confidence interval = 1.3-19.6). There was a positive though not statistically significant (odds ratio = 1.7, p = 0.175) association noted between family history of cardiovascular disease and fibromuscular dysplasia.(ABSTRACT TRUNCATED AT 250 WORDS)
Sang
C N
CN
Outpatient Clinical Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
Whelton
P K
PK
Hamper
U M
UM
Connolly
M
M
Kadir
S
S
White
R I
RI
Sanders
R
R
Liang
K Y
KY
Bias
W
W
D000328:Adult; D015901:Angiography, Digital Subtraction; D001157:Arterial Occlusive Diseases / Q000209:etiology*; D002318:Cardiovascular Diseases / Q000235:genetics; D016022:Case-Control Studies; D003276:Contraceptives, Oral / Q000009:adverse effects; D005260:Female; D005352:Fibromuscular Dysplasia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000276:immunology; D005831:Genital Diseases, Female / Q000150:complications; D006680:HLA Antigens / Q000032:analysis / Q000145:classification; D006801:Humans; D006973:Hypertension / Q000150:complications; D007668:Kidney / Q000502:physiology; D008875:Middle Aged; D012077:Renal Artery; D012119:Respiration; D012907:Smoking / Q000009:adverse effects; D014463:Ultrasonography
D003276:Contraceptives, Oral; D006680:HLA Antigens