Comparison of two combined diuretics in the treatment of essential hypertension.
The efficacy and safety of two combination drugs, consisting of a diuretic + a K-sparing agent, were investigated in the treatment of essential hypertension. A double-blind, randomized, parallel group study design was employed. After randomization, 14 patients were treated with 10 mg xipamide + 30 mg triamterene (A) and 16 with 25 mg hydrochlorothiazide + 50 mg triamterene (B). The patients suffered from essential hypertension with a systolic blood pressure (SBP) at entry of greater than or equal to 150 mmHg and a diastolic blood pressure (DBP) of greater than or equal to 95 mmHg. After 6 weeks, mean decline in DBP was 12% in group A and 9% in group B, respectively. With treatment A, one patient became hypokalemic and with treatment B one patient became hyperkalemic.
Verhiest
W
W
Department of Internal Medicine, St. Jozefskliniek, Izegem, Belgium.
Baehre
M
M
Volkers
P
P
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D011897:Random Allocation; D014223:Triamterene / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014988:Xipamide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D004232:Diuretics; D014280:Triglycerides; D006852:Hydrochlorothiazide; D014527:Uric Acid; D014988:Xipamide; D002784:Cholesterol; D011188:Potassium; D014223:Triamterene