Bilateral renal agenesis and Mullerian anomalies in a 47,XXX fetus.
Congenital absence of the kidneys (bilateral renal agenesis, BRA) is a genetically heterogeneous condition, and all modes of inheritance have been suggested as causes. The finding of a 47,XXX chromosome constitution in a fetus with BRA and developmental arrest of the mesonephric and paramesonephric systems raises the possibility that X chromosome trisomy also may cause the urogenital adysplasia sequence.
Hogge
W A
WA
Department of Obstetrics, University of Virginia, Charlottesville 22908.
Vick
D J
DJ
Schnatterly
P A
PA
MacMillan
R H
RH
D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000235:genetics*; D005817:Genetic Counseling; D006801:Humans; D007668:Kidney / Q000002:abnormalities*; D009095:Mullerian Ducts / Q000473:pathology*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014314:Trisomy; D014463:Ultrasonography; D014960:X Chromosome