title: Suprarenal aortic flow reduction versus angiotensin I infusion in fetal sheep.
abstract: In the unanaesthetized fetal sheep, long-term suprarenal aortic blood flow reduction will cause upper body arterial blood pressure to increase. To see if the response to this procedure was entirely due to the concomitant increase in plasma renin activity, we gave an angiotensin I infusion of several days to 7 fetal sheep and compared their responses to those of 4 fetal sheep undergoing partial occlusion of the aorta above the renal arteries. Both protocols caused upper body arterial blood pressure to increase to comparable levels. Angiotensin I infusion had no effect upon venous blood pressure while suprarenal aortic blood flow reduction caused a significant increase in venous blood pressure as early as 1 day after blood flow reduction. Haematocrits were unchanged in the fetuses with flow restriction but increased in the infused fetuses. We conclude that long-term angiotensin I infusion in the fetus does not mimic the entire complex of responses to suprarenal aortic blood flow reduction.
authors.affiliation: Department of Physiology, Oregon Health Sciences University, Portland 97201.
authors.forename: D F
authors.initials: DF
authors.lastname: Anderson
authors.forename: N D
authors.initials: ND
authors.lastname: Binder
mesh_terms: D000803:Angiotensin I / Q000494:pharmacology*; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D006400:Hematocrit; D006973:Hypertension / Q000503:physiopathology; D007262:Infusions, Intravenous; D012079:Renal Circulation / Q000187:drug effects*; D012083:Renin / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology*; D012756:Sheep; D014690:Venous Pressure / Q000187:drug effects
chemical_list: D000803:Angiotensin I; D012083:Renin