title: [Synthesis and pharmacologic study of pyridazino[4,5-b]carbazoles].
abstract: Cyclization reaction of hydrazine with carbazole-2,3-methyl dicarboxylates gave 1,4-dioxo-1,2,3,4-tetrahydropyridazino[4,5-b]carbazoles. Chlorodehydroxylation provided 1,4-dichloropyridazino[4,5-b]carbazoles and nucleophilic substitution gave 1,4-dialkoxy pyridazino[4,5-b]carbazoles. These compounds were tested for cytotoxic activity against L1210 leukemia in mice.
authors.forename: H
authors.initials: H
authors.lastname: Landelle
authors.forename: D
authors.initials: D
authors.lastname: Laduree
authors.forename: M
authors.initials: M
authors.lastname: Cugnon de Sevricourt
authors.forename: M
authors.initials: M
authors.lastname: Robba
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D009153:Mutagens; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles; D009153:Mutagens; D011724:Pyridazines
vernacular_title: Synthèse et etude pharmacologique de pyridazino[4,5-b]carbazoles.