Polypeptide neutrophil chemoattractants in the skin.
Extracts of stratum corneum samples from psoriatic skin lesions have been shown to contain a group of neutrophil chemoattractant polypeptides, a major portion of which is distinct from C5a (des arg). One of the components may be identical to the novel monocyte-derived neutrophil chemotactic peptide which has recently been purified, sequenced and cloned. Synthesis of this agent may be induced by interleukin 1, this process possibly explaining part of the pro-inflammatory activity of interleukin 1 in the skin. These compounds may be important in the pathogenesis of inflammatory skin disease.
Camp
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RD
Institute of Dermatology, St. Thomas's Hospital, London, UK.
D002630:Chemotactic Factors / Q000032:analysis*; D002634:Chemotaxis, Leukocyte; D006801:Humans; D007249:Inflammation; D007375:Interleukin-1 / Q000276:immunology / Q000502:physiology; D016209:Interleukin-8; D009000:Monocytes; D009504:Neutrophils / Q000276:immunology / Q000502:physiology; D011565:Psoriasis / Q000276:immunology; D012867:Skin / Q000276:immunology*
D002630:Chemotactic Factors; D007375:Interleukin-1; D016209:Interleukin-8