title: Signal transduction by p21ras.
abstract: Experiments using the physical loading of purified recombinant p21 ras proteins into quiescent normal cells to analyze how the proteins stimulate DNA synthesis and morphological transformation are reviewed. The results indicate that oncogenic p21ras proteins rapidly activate a protein-kinase-C-dependent pathway and a protein-kinase-C-independent pathway. The activation of protein kinase C is absolutely required for p21ras to stimulate DNA synthesis but is not required for morphological transformation.
authors.affiliation: Institute of Cancer Research, Royal Cancer Hospital, Chester Beatty Laboratories, London, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Marshall
authors.forename: A C
authors.initials: AC
authors.lastname: Lloyd
authors.forename: J D
authors.initials: JD
authors.lastname: Morris
authors.forename: H
authors.initials: H
authors.lastname: Paterson
authors.forename: B
authors.initials: B
authors.lastname: Price
authors.forename: A
authors.initials: A
authors.lastname: Hall
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004789:Enzyme Activation; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology; D051379:Mice; D015689:Oncogene Protein p21(ras) / Q000502:physiology*; D011493:Protein Kinase C / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D015398:Signal Transduction
chemical_list: D011518:Proto-Oncogene Proteins; D007334:Insulin-Like Growth Factor I; D004247:DNA; D011493:Protein Kinase C; D015689:Oncogene Protein p21(ras)