title: The nucleotide sequence of a mouse renin-encoding gene, Ren-1d, and its upstream region.
abstract: The renin-encoding genes have been cloned from high (Ren-1d, Ren-2d)- and low (Ren-1c)-renin-producing strains of mice (DBA/2J and C57BL/10). Each of the genes is approx. 9.6 kb in length and consists of nine exons and eight introns. The entire nucleotide sequence of the Ren-1d gene has been determined and the 5'-flanking regions of the three genes, Ren-1c, Ren-1d and Ren-2d, have been compared. The significance of several potential regulatory signals found in the DNA is discussed.
authors.affiliation: Department of Biochemistry, University of Leicester, U.K.
authors.forename: D W
authors.initials: DW
authors.lastname: Burt
authors.forename: L J
authors.initials: LJ
authors.lastname: Mullins
authors.forename: H
authors.initials: H
authors.lastname: George
authors.forename: G
authors.initials: G
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Brooks
authors.forename: D
authors.initials: D
authors.lastname: Pioli
authors.forename: W J
authors.initials: WJ
authors.lastname: Brammar
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005091:Exons; D005796:Genes; D005809:Genes, Regulator; D007438:Introns; D008099:Liver / Q000201:enzymology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008969:Molecular Sequence Data; D012326:RNA Splicing; D012083:Renin / Q000235:genetics*; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D012984:Software; D013045:Species Specificity
chemical_list: D004247:DNA; D012083:Renin