Hemodynamic actions of endothelin in conscious and anesthetized dogs.
The newly described endogenous peptide, endothelin, was administered to five chronically instrumented conditioned dogs. Endothelin produced significant and simultaneous increases in both heart rate (HR) and mean arterial pressure (MAP) in conscious dogs. Endothelin also produced significant increases in MAP in anesthetized animals. Ganglionic suppression induced by hexamethonium (10 mg/kg) and atropine (0.1 mg/kg) blocked HR responses and markedly inhibited the pressor responses to endothelin in conscious animals. These results suggest that endothelin in part acts to elevate blood pressure and heart rate through modification of autonomic nervous system tone. When endothelin and angiotensin II were administered in mole equivalent doses, angiotensin II produced a pressor response of greater magnitude than did endothelin in conscious animals.
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Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112.
Lowe
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Lippton
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Hyman
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Sander
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Giles
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TD
D000768:Anesthesia, General; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D003243:Consciousness; D004285:Dogs; D016232:Endothelins; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D005725:Ganglia, Autonomic / Q000187:drug effects / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects*; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D012016:Reference Values
D016232:Endothelins; D006584:Hexamethonium Compounds; D010455:Peptides; D000804:Angiotensin II; D001285:Atropine