Immune regulation in IgA nephropathy.
Regulation in IgA nephropathy (IgA N) has been largely studied. We present in this work our recent data which suggest that an abnormal chemical structure and/or molecular form of serum immunoglobulin A (IgA) might contribute to both the mesangial deposition of IgA and the T cell abnormalities which may in turn deregulate the IgA synthesis.
Monteiro
R C
RC
Département de Néphrologie et INSERM U 25, Hôpital Necker, Paris.
Noël
L H
LH
Chevailler
A
A
Halbwachs-Mecarelli
L
L
Lesavre
P
P
D000936:Antigen-Antibody Complex / Q000276:immunology; D005920:Glomerular Mesangium / Q000276:immunology; D005922:Glomerulonephritis, IGA / Q000276:immunology*; D006706:Homeostasis; D006801:Humans; D007109:Immunity; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000276:immunology; D011961:Receptors, Fc / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D011961:Receptors, Fc