Mechanisms of adaptive supersensitivity in smooth muscles vs cardiac muscle: a brief review.
1. Depending upon the type of cell being studied, adaptive supersensitivity has been traced to molecular changes in receptors, the Na+/K+ pump or the G-protein/adenylate cyclase system. 2. Evidence is reviewed that indicates that adaptive supersensitivity in guinea-pig atria is the result of changes in the G-protein/adenylate cyclase system.
Fleming
W W
WW
Department of Pharmacology and Toxicology, West Virginia University Health Sciences Center, Morgantown.
D000818:Animals; D006321:Heart / Q000502:physiology*; D006801:Humans; D009130:Muscle, Smooth / Q000502:physiology*; D009132:Muscles / Q000502:physiology*