[Comparative studies of the recombinogenic action of some pesticides on yeasts in the absence and presence of metabolic activation].
Recombinogenic activity of five pesticides (dimatyph, endosulfan, cypermethrin, picloram and crotoxyphos) has been studied on yeasts Saccharomyces cerevisiae under conditions of metabolic activation and without it. Treatment of yeasts by microsomal activating mixtures (S9 fractions of hens and rats) promoted no formation of active metabolites. Active pesticides (dimatyph, endosulfan, picloram) under conditions of metabolic activation induced the detoxication process.
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D000818:Animals; D001711:Biotransformation; D002645:Chickens; D009153:Mutagens / Q000493:pharmacokinetics; D010575:Pesticides / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D011995:Recombination, Genetic / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*
D009153:Mutagens; D010575:Pesticides
Sravnitel'noe izuchenie na drozhzhakh rekombinogennogo deĭstviia riada pestitsidov pri otsutstvii i nalichii metabolichesskoĭ aktivatsii.