title: Antibodies to Plasmodium falciparum ring-infected erythrocyte surface antigen and P. falciparum and P. malariae circumsporozoite proteins: seasonal prevalence in Kenyan villages.
abstract: Two cross-sectional surveys of 954 persons in Asembo Bay and Got Nyabondo, western Kenya, were performed in August-September 1986, after long rains, and in February-March 1987, after a comparatively dry season. Serologic testing was performed using an ELISA with synthetic peptides representing repeat amino acid sequences of the Plasmodium falciparum ring-infected erythrocyte surface antigen (RESA), (EENV)5, (EENVEHDA)4, and (DDEHVEEPTVA)2 and repeat sequences (PNAN)5 and (NAAG)5 of the P. falciparum and P. malariae circumsporozoite proteins. In 1986, 45%, 73%, 72%, 85%, and 59% of the persons in Asembo Bay had antibodies to the respective peptides. In Got Nyabondo, the rates were 44%, 67%, 56%, 36%, and 41%, respectively. All positivity rates increased with age. When next determined in 1987, the positivity rates and levels of reactivity were generally unchanged in Asembo Bay, but were decreased in Got Nyabondo.
authors.affiliation: Centers for Disease Control, Atlanta, Georgia.
authors.forename: P
authors.initials: P
authors.lastname: Deloron
authors.forename: G H
authors.initials: GH
authors.lastname: Campbell
authors.forename: D
authors.initials: D
authors.lastname: Brandling-Bennett
authors.forename: J M
authors.initials: JM
authors.lastname: Roberts
authors.forename: I K
authors.initials: IK
authors.lastname: Schwartz
authors.forename: J S
authors.initials: JS
authors.lastname: Odera
authors.forename: A A
authors.initials: AA
authors.lastname: Lal
authors.forename: C O
authors.initials: CO
authors.lastname: Osanga
authors.forename: V
authors.initials: V
authors.lastname: de la Cruz
authors.forename: T M
authors.initials: TM
authors.lastname: McCutchan
mesh_terms: D000293:Adolescent; D000375:Aging / Q000276:immunology*; D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004912:Erythrocytes / Q000276:immunology / Q000469:parasitology*; D006801:Humans; D007223:Infant; D008288:Malaria / Q000453:epidemiology / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology; D010965:Plasmodium malariae / Q000276:immunology; D012621:Seasons; D016036:Seroepidemiologic Studies
chemical_list: D000913:Antibodies, Protozoan; D000954:Antigens, Surface