title: [A 3-month, randomized double-blind dose-response study with 0-(beta-hydroxyethyl)-rutoside oral solutions].
abstract: The antioedematous effect of 0-(beta-Hydroxylethyl)-rutoside (HR)-drinking solutions with 600, 900, 1200 and 1500 mg active substance was tested in a randomized double-blind study against placebo with 30 female patients in the change of life. The decrease of the oedemas was measured by recording the change in the leg volume. The patients valued the symptoms "tired and heavy legs", "tenseness" and "tingling sensation". After 3 months the daily taking of HR-drinking solutions showed a significant decrease of leg volume. At the end of the treatment there was no significant difference between the four verum groups.
authors.forename: W
authors.initials: W
authors.lastname: Nocker
authors.forename: W
authors.initials: W
authors.lastname: Diebschlag
authors.forename: W
authors.initials: W
authors.lastname: Lehmacher
mesh_terms: D000284:Administration, Oral; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006896:Hydroxyethylrutoside / Q000008:administration & dosage*; D008209:Lymphedema / Q000188:drug therapy*; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012431:Rutin / Q000031:analogs & derivatives*; D014689:Venous Insufficiency / Q000188:drug therapy*
chemical_list: D006896:Hydroxyethylrutoside; D012431:Rutin
vernacular_title: 3monatige, randomisierte doppelblinde Dosis-Wirkungsstudie mit 0-(Beta-Hydroxyäthyl)-rutosid-Trinklösungen.