[Prevention of iron-deficiency anemia in pregnancy using early iron supplementation: a controlled trial].
An iron supplementation trial versus placebo was performed in double blind on 191 attending at 3 month the antenatal clinic of Poissy maternity. Iron status of mothers and newborns was assessed at 3, 5, 7 month, during the delivery and 2 months after the delivery, using biochemical indicators (hemoglobin level, serum ferritin). The compliance was good in 165 pregnant women (86% of the initial sample): 81 in the iron group, 84 in the placebo group. Among the placebo group, anemia (Hb less than 11 g/dl) was observed at the end of the pregnancy in 30% of women. Depletion of iron stores started at 5 month. In the iron group, hemoglobin level increased significantly during the pregnancy and anemia was observed only in 3% of women at the delivery. Iron status of newborns and two months after delivery was related to mothers iron status at delivery and particularly at the 7th month of pregnancy.
De Benaze
C
C
Centre de Recherche sur les Anémies Nutritionnelles, CNAM, Paris.
Galan
P
P
Wainer
R
R
Hercberg
S
S
D000328:Adult; D000747:Anemia, Hypochromic / Q000097:blood / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005293:Ferritins / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007501:Iron / Q000627:therapeutic use*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*
D006454:Hemoglobins; D005293:Ferritins; D007501:Iron
Prévention de l'anémie ferriprive au cours de la grossesse par une supplémentation martiale précoce: un essai contrôlé.