title: Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies.
abstract: Ganoderan B increased the plasma insulin level in normal and glucose-loaded mice but elicited no effect on insulin binding to isolated adipocytes. Administration of ganoderan B elicited significant increases of the activities of hepatic glucokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase, decreased the hepatic glucose-6-phosphate and glycogen synthetase activities and did not affect the activities of hexokinase and glycogen phosphorylase. Ganoderan B reduced the glycogen content in the liver but had no influence on total cholesterol and triglyceride levels in the plasma and liver.
authors.forename: H
authors.initials: H
authors.lastname: Hikino
authors.forename: M
authors.initials: M
authors.lastname: Ishiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: C
authors.initials: C
authors.lastname: Konno
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000097:blood*; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D011134:Polysaccharides / Q000494:pharmacology*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D007328:Insulin; D011134:Polysaccharides; D014280:Triglycerides; D002784:Cholesterol; C047407:ganoderan B; D005947:Glucose