Regulation of breast cancer cells by hormones and growth factors: effects on proliferation and basement membrane invasiveness.
The current understanding of the regulation of breast cancer cell proliferation and invasiveness by hormones and growth factors is reviewed. It has been shown that polypeptide growth factors are involved in hormone-independent breast cancer, and are sometimes oestrogen-regulated in hormone-responsive models. Basement-membrane invasiveness, relating to the metastatic potential of these cells, is also stimulated by oestrogen in hormone-dependent models, elevated in hormone-independent models, and is growth factor sensitive. Further understanding of the differential effects of growth factors on breast cancer cell proliferation and invasiveness should facilitate better therapeutic exploitation of regulation at this level.
Thompson
E W
EW
Vincent T Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, D.C.
Martin
M B
MB
Saceda
M
M
Clarke
R
R
Brunner
N
N
Lippman
M E
ME
Dickson
R B
RB
D000818:Animals; D001485:Basement Membrane / Q000502:physiology; D001943:Breast Neoplasms / Q000503:physiopathology*; D002455:Cell Division / Q000502:physiology; D002460:Cell Line; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000503:physiopathology*