title: [The results of a modified FAMeth chemotherapy protocol in metastatic stomach carcinoma].
abstract: Fifty patients with locally far progressed or metastasizing gastric carcinoma were treated with 5-fluorouracil, adriamycin and methotrexate using a slight modification of the FAMeth schema. Full remission was achieved in four patients, confirmed at a second-look operation. Partial remission was achieved in 13 patients, two of whom went into full remission after operative removal of residual tumour. Median duration of remission for the six patients in full remission was 21 months, for those in partial remission five months. Median survival of all 50 patients was seven months, of those in full and partial remission 12 months, and those without remission four months. The results indicate that this protocol of combined operation and chemotherapy can further improve the results of treating metastasizing gastric carcinoma.
authors.affiliation: Abteilung für Onkologie und Hämatologie, II. Medizinische Klinik und Poliklinik, Universitätskrankenhaus Eppendorf, Hamburg.
authors.forename: H J
authors.initials: HJ
authors.lastname: Weh
authors.forename: D
authors.initials: D
authors.lastname: Platz
authors.forename: M
authors.initials: M
authors.lastname: Garbrecht
authors.forename: B
authors.initials: B
authors.lastname: Kremer
authors.forename: D
authors.initials: D
authors.lastname: Henne-Bruns
authors.forename: W
authors.initials: W
authors.lastname: Crone-Münzebrock
authors.forename: D K
authors.initials: DK
authors.lastname: Hossfeld
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D009362:Neoplasm Metastasis; D011446:Prospective Studies; D012074:Remission Induction; D012086:Reoperation; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D013997:Time Factors
chemical_list: D004317:Doxorubicin; D005472:Fluorouracil; D008727:Methotrexate
vernacular_title: Ergebnisse eines modifizierten FAMeth-Chemotherapieprotokolls beim metastasierten Magenkarzinom.