Genomic alterations in human breast cancer: a review.
We review and discuss data on the genetic alterations documented in human breast carcinomas at the molecular level. These alterations may result in: 1) deletion of genetic material (chromosome 11p, 13q, 3p, 1q, 17p); 2) amplification of genes or entire chromosomal segments (c-myc, c-erb-B2, locus DF3/PUM, loci on 11q13); 3) rearrangements (c-myc); 4) point mutations (c-ras). Presently available informations do not allow the development of cohesive pathogenetic models but indicate that the molecular basis of human breast cancer is heterogeneous.
Mariani-Costantini
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R
Istituto di Patologia Umana e Medicina Sociale, Università G. D'Annunzio, Chieti, Italy.
Merlo
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Frati
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L
D001943:Breast Neoplasms / Q000235:genetics*; D002872:Chromosome Deletion; D005260:Female; D005784:Gene Amplification; D015321:Gene Rearrangement; D011905:Genes, ras; D006801:Humans; D009154:Mutation; D011519:Proto-Oncogenes; D014162:Transfection