Sustained prevention of myocardial and metabolic abnormalities in diabetic rats following withdrawal from oral vanadyl treatment.
Earlier studies revealed a general amelioration of diabetes-induced alterations in the rat following chronic oral vanadyl treatment. Recently, some streptozotocin-diabetic animals treated similarly were observed to remain euglycemic after withdrawal from vanadyl. In the present study, the diabetic profile of these animals (STZ-T) was investigated. After 3 weeks of treatment with vanadyl followed by 13 weeks of withdrawal, plasma concentrations of glucose, insulin, lipids, and thyroid hormones in the STZ-T animals were returned to control levels. Myocardial dysfunction and increased glycerol output from adipose tissue in untreated-diabetic (STZ) rats were also found to be normalized in the STZ-T group. Furthermore, there was no evidence of cataracts in these animals compared with age-matched STZ rats. These findings indicate that short-term oral treatment of diabetic rats with vanadyl induces beneficial changes that persist following withdrawal of the treatment. The results of these studies may suggest a possible new treatment protocol that could be incorporated into the management of diabetes.
Ramanadham
S
S
Division of Pharmacology, University of British Columbia, Vancouver, Canada.
Brownsey
R W
RW
Cros
G H
GH
Mongold
J J
JJ
McNeill
J H
JH
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D046508:Culture Techniques; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005990:Glycerol / Q000378:metabolism; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D013963:Thyroid Hormones / Q000378:metabolism; D014639:Vanadium / Q000494:pharmacology*; D017968:Vanadium Compounds
D001786:Blood Glucose; D007328:Insulin; D013963:Thyroid Hormones; D017968:Vanadium Compounds; D014639:Vanadium; C034028:vanadyl sulfate; D005990:Glycerol