title: An immunohistochemical study of beta-protein in Alzheimer-type dementia brains.
abstract: An immunohistochemical study with a polyclonal anti-beta-protein antiserum was performed in order to understand the mechanism of deposition of amyloid fibrils in senile plaques in Alzheimer-type dementia (ATD). Serial cortical sections cut from ATD brains were necessary to investigate the structural correlation between senile plaques and blood vessels. The senile plaques were stained well and a blood vessel or capillary-like structure was found in most of beta-protein-immunoreactive deposits. These findings may suggest an involvement of blood vessels in the formation of at least some of the amyloid deposits in ATD brains.
authors.affiliation: Department of Psychopharmacology, Psychiatric Research Institute of Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: N
authors.initials: N
authors.lastname: Sagi
authors.forename: I
authors.initials: I
authors.lastname: Noguchi
authors.forename: S
authors.initials: S
authors.lastname: Haga
authors.forename: T
authors.initials: T
authors.lastname: Ishii
authors.forename: Y
authors.initials: Y
authors.lastname: Makino
authors.forename: K
authors.initials: K
authors.lastname: Kosaka
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D000682:Amyloid / Q000032:analysis*; D016229:Amyloid beta-Peptides; D001923:Brain Chemistry; D002196:Capillaries / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D009419:Nerve Tissue Proteins / Q000032:analysis*
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D009419:Nerve Tissue Proteins