title: Validity of the mean parenchymal transit time as a screening test for the detection of functional renal artery stenosis in hypertensive patients.
abstract: Functional significance of renal artery stenosis (RAS) was assessed by 99Tcm-DTPA radionuclide scintigraphy, using the mean parenchymal transit time (MPTT) of the tracer as an index of renovascular disorder. Two groups of subjects were investigated retrospectively: eight normal live kidney donors; and 11 patients with hypertension, six with and five without significant RAS. MPTT was 171 +/- 11 s in the kidney donors, and there was a significantly prolonged MPTT in patients with RAS, 313 +/- 27 s (p less than 0.05). MPTT was also prolonged in three hypertensive patients with intrinsic renal disorders. The advantages and limitations of this technique are discussed. It is concluded that prolongation of MPTT can detect functionally significant renovascular disorder without pharmacological challenge.
authors.affiliation: Department of Nuclear Medicine, St Bartholomew's Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: al-Nahhas
authors.forename: A J
authors.initials: AJ
authors.lastname: Marcus
authors.forename: J
authors.initials: J
authors.lastname: Bomanji
authors.forename: C C
authors.initials: CC
authors.lastname: Nimmon
authors.forename: J E
authors.initials: JE
authors.lastname: Dacie
authors.forename: K E
authors.initials: KE
authors.lastname: Britton
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging* / Q000503:physiopathology; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D011859:Radiography; D011866:Radioisotope Renography; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging / Q000503:physiopathology; D012082:Renal Veins; D012083:Renin / Q000097:blood; D012189:Retrospective Studies; D016284:Technetium Tc 99m Pentetate
chemical_list: D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D012083:Renin; D016284:Technetium Tc 99m Pentetate