title: [Captopril and hydrochlorothiazide combined in the treatment of mild-to-moderate hypertension. Evaluation of sugar and lipid metabolism in a long-term study].
abstract: Ten hypertensive patients (I-IIWHO) were treated for a period of three months with captopril 50 mg + hydrochlorothiazide 25 mg once or twice daily, with the aim of evaluating the antihypertensive effectiveness of this association and the lack of influences on lipid and mainly glucose metabolism. Blood pressure and heart rate were evaluated every month, while chemical tests were performed at the beginning and at the end of the trial. Besides before and after treatment were studied blood glucose and insulin levels during oral glucose tolerance test, at times 0, 15', 30', 60', 90', 120', 180'. Our data show that captopril combined with hydrochlorothiazide has a good antihypertensive action, and doesn't alter lipid and glucose metabolism either after oral glucose tolerance test.
authors.affiliation: Divisione Medica III, Ospedale L. Sacco, Milano.
authors.forename: E
authors.initials: E
authors.lastname: Malacco
authors.forename: M
authors.initials: M
authors.lastname: Magenta
authors.forename: E
authors.initials: E
authors.lastname: Noia
authors.forename: E
authors.initials: E
authors.lastname: Renesto
authors.forename: C
authors.initials: C
authors.lastname: Sartini
authors.forename: G F
authors.initials: GF
authors.lastname: Botta
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002216:Captopril / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology / Q000627:therapeutic use*; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D008055:Lipids; D006852:Hydrochlorothiazide; D002216:Captopril
vernacular_title: Captopril e idroclorotiazide associati nel trattamento della ipertensione lieve-moderata. Valutazione del metabolismo glucidico e lipidico in uno studio a lungo termine.