title: Oxalato-platinum or 1-OHP, a third-generation platinum complex: an experimental and clinical appraisal and preliminary comparison with cis-platinum and carboplatinum.
abstract: A new platinum complex, oxalatoplatin or l-OHP, which, at the same metal dose in experimental tests is as efficient as cisplatin, and is more so at a lower metal dose than carboplatin; which is as efficient in human tumors of the testis and ovary as these other analogs, and more so in melanoma and breast cancer; which is not nephrotoxic, cardiotoxic or mutagenic, and hardly hematotoxic and neurotoxic, is described and compared with the above-mentioned platinum complexes. Combined with 5Fu, it induces a high number of remissions in colorectal cancer, and has brought about cures in inoperable gastric cancers. Combined with carboplatin, it has resulted in a high proportion of cures in L1210-carrying mice, which no other two-by-two combination of these complexes has achieved.
authors.affiliation: Départment des Maladies Sanguines, Immunitaires et Tumorales & ICIG, Hôpital Paul-Brousse, Villejuif, France.
authors.forename: G
authors.initials: G
authors.lastname: Mathé
authors.forename: Y
authors.initials: Y
authors.lastname: Kidani
authors.forename: M
authors.initials: M
authors.lastname: Segiguchi
authors.forename: M
authors.initials: M
authors.lastname: Eriguchi
authors.forename: G
authors.initials: G
authors.lastname: Fredj
authors.forename: G
authors.initials: G
authors.lastname: Peytavin
authors.forename: J L
authors.initials: JL
authors.lastname: Misset
authors.forename: S
authors.initials: S
authors.lastname: Brienza
authors.forename: F
authors.initials: F
authors.lastname: de Vassals
authors.forename: E
authors.initials: E
authors.lastname: Chenu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016190:Carboplatin; D002945:Cisplatin / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004341:Drug Evaluation; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000077150:Oxaliplatin; D010215:Papio
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D016190:Carboplatin; D002945:Cisplatin; D005472:Fluorouracil