title: Prediction approaches to sequentially searching for an optimal dose.
abstract: The search for an optimal dose of a drug has been investigated in a sequential setting to ensure the safety level by Eichhorn and Zacks (1973, Journal of the American Statistical Association 68, 594-598; 1981, Communications in Statistics--Theory and Methods A10, 931-953), Eichhorn (1974, Communications in Statistics 3, 263-271), and Robinson (1978, Biometrika 65, 75-78). In this paper the procedure proposed by Robinson is given a new interpretation in terms of mean coverage tolerance prediction, and a new procedure in terms of guaranteed coverage tolerance prediction is proposed. The new procedure has better properties and is more stringent, and hence more desirable for safety consideration.
authors.affiliation: Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065-0914.
authors.forename: W J
authors.initials: WJ
authors.lastname: Shih
mesh_terms: D001699:Biometry / Q000379:methods*; D002986:Clinical Trials as Topic; D004361:Drug Tolerance; D006801:Humans; D015233:Models, Statistical; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
chemical_list: D004364:Pharmaceutical Preparations