Synthesis of some thiazoline and thiazolidinone derivatives of 1,4-benzoquinone as potential antimicrobial agents.
Three novel series of benzoquinone derivatives were synthesized, namely: N-(3-aryl-4-phenylthiazolin-2-ylidene)-N-(1,4-benzoquinone carbonyl) hydrazines; N-(3-aryl-5-carbethoxy-4-methylthiazolin-2-ylidene)-N-(1,4- benzoquinone carbonyl)hydrazine and N-(3-arylthiazolin-4-one-2-ylidene)-N-(1,4- benzoquinone carbonyl) hydrazines. These series were prepared by oxidation of the new hydroquinone precursors. The antimicrobial activity of representative compounds of benzoquinone, as well as of hydroquinone derivatives was studied.
el-Khawass
S M
SM
Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Egypt.
Khalil
M A
MA
Chaaban
I
I
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D016227:Benzoquinones; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011809:Quinones / Q000138:chemical synthesis*; D013211:Staphylococcus aureus / Q000187:drug effects; D013844:Thiazoles / Q000138:chemical synthesis*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D016227:Benzoquinones; D011809:Quinones; D013844:Thiazoles; C004532:quinone