title: Necrobacillosis and immunity in mice.
abstract: The study arose from the recent finding that sub-lethal numbers of certain bacterial species greatly enhanced the infectivity of Fusobacterium necrophorum. A severe F. necrophorum infection in mice, cured with metronidazole, produced significant though slight resistance, which was demonstrable by challenge with a minute dose of F. necrophorum (less than 20 organisms) suspended in a sub-lethal dose of Escherichia coli (300 x 10(6) organisms) to enhance fusobacterial infectivity. In an earlier comparable experiment, challenge with F. necrophorum alone, in necessarily large doses (greater than or equal to 3 x 10(6) organisms), failed to demonstrate that a single cured fusobacterial infection gave rise to resistance; such an infection neither protected against the fatal necrobacillosis produced by challenge nor prolonged survival. A sub-lethal E. coli infection was also shown by challenge with a minute dose of F. necrophorum (less than 10 organisms), suspended in a sub-lethal dose of E. coli (152 x 10(6) organisms), to produce significant though slight protection against necrobacillosis. The degrees of resistance demonstrated were too slight to give any encouragement to the prospect of an effective necrobacillosis vaccine.
authors.affiliation: Nuffield Laboratories of Comparative Medicine, Institute of Zoology, Zoological Society of London.
authors.forename: G R
authors.initials: GR
authors.lastname: Smith
authors.forename: L M
authors.initials: LM
authors.lastname: Wallace
authors.forename: D
authors.initials: D
authors.lastname: Till
mesh_terms: D000818:Animals; D004926:Escherichia coli / Q000276:immunology; D004927:Escherichia coli Infections / Q000150:complications / Q000276:immunology*; D005673:Fusobacterium / Q000276:immunology; D005674:Fusobacterium Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000517:prevention & control; D007114:Immunization; D008795:Metronidazole / Q000627:therapeutic use; D051379:Mice
chemical_list: D008795:Metronidazole