[Scintigraphy of sustained-release agar-embedded insulin suppositories].
In earlier publications [1-3] we reported on the retardation and protective effect of insulin-agar-embeddings in triglyceride suppositories by in vitro and in vivo tests on rabbits. The discovered effects were visually followed by gammascintigraphic test of adequate rectally applied 131I-insulin-specimens in the rectum and thyroid gland and, in relation with the glucose lowering course, the liberation, distribution and bioavailability of the immobilized hormone was illustrated.
Losse
G
G
Sektion Chemie der Technischen Universität Dresden.
Müller
F
F
Fischer
S
S
Wunderlich
G
G
Hacker
E
E
D000362:Agar; D000818:Animals; D002626:Chemistry, Pharmaceutical; D007328:Insulin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008297:Male; D011817:Rabbits; D011877:Radionuclide Imaging; D013488:Suppositories
D007328:Insulin; D013488:Suppositories; D000362:Agar
Szintigraphische Verfolgung der retardierten Insulinliberation aus Agar-Einbettungen in Suppositorien.