Distribution and anchoring of molecular forms of acetylcholinesterase.
Molecular forms of acetylcholinesterase exhibit tissue-specific distribution, and each form is anchored to the cell surface via a particular post-translational modification of the catalytic subunit. Nibaldo Inestrosa and Alejandra Perelman review evidence that heparan sulphate proteoglycans are the extracellular matrix receptors for the collagen-tailed enzyme, and that a glycolipid which contains phosphatidylinositol and a 20 kDa hydrophobic peptide participate in the anchoring of the hydrophobic globular forms of acetylcholinesterase to the cell surface.
Inestrosa
N C
NC
Perelman
A
A
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D007527:Isoenzymes; D014018:Tissue Distribution
D007527:Isoenzymes; D000110:Acetylcholinesterase