[Serotonin, food intake and body weight].
Various animal models of hyperphagia and obesity have made possible the study of the effect on food intake of dexfenfluramine, an agent which both inhibits reuptake and stimulates release of 5 HT. These are chronic overfeeding models (hereditary model: Zucker rat, hormonal origin: insulin, ovariectomy, lesions of the VMH, and models including palatable and varied diet: cafétéria diet) and also acute overfeeding models (deprived rats, tail pinch, "dessert" test, metabolic or neuropharmacologic stimuli). Dexfenfluramine administered by osmotic minipump (3 mg/kg/day for up to 4 weeks) reduces food intake and produces weight loss in most of these models.
Rowland
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NE
Département de Psychologie, Université de Floride, Gainesville 32611.
Souquet
A M
AM
D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D004435:Eating; D005247:Feeding Behavior / Q000187:drug effects; D005277:Fenfluramine / Q000494:pharmacology; D006801:Humans; D006963:Hyperphagia / Q000503:physiopathology; D051379:Mice; D009765:Obesity / Q000209:etiology / Q000503:physiopathology*; D051381:Rats; D012701:Serotonin / Q000502:physiology*
D005277:Fenfluramine; D012701:Serotonin
Sérotonine, prise alimentaire et poids corporel.