Genes of susceptibility to cancer.
As opposed to dominantly-acting oncogenes, antioncogenes represent a new class of tumor suppressor genes, the prototype of which is the gene for retinoblastoma. Hereditary predisposition to cancer can be due to alteration of one copy of an antioncogene, while a tumor will develop only when the second copy is altered by a somatic mutation.
Junien
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INSERM, Unité 73, Paris, France.
D000818:Animals; D004198:Disease Susceptibility; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes; D013489:Suppression, Genetic