Chromatographic methods and selective detectors in pharmacokinetics.
The quantitative evaluation of drugs in biological samples requires them to be estimated at concentrations associated with pharmacological activity, which range between fractions of ng and hundreds of ug per ml of plasma. Chromatographic techniques are generally used in this evaluation. This review deals with the detectors most frequently used in chromatographic apparatus (GLC and HPLC), their selective performance and the derivatization reactions involved in the quantitative evaluation of drugs in biological samples at active therapeutic concentrations.
Marzo
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D002845:Chromatography; D010599:Pharmacokinetics