title: [Changes in collagen connective tissue and fibroblasts in aging].
abstract: Some of the characteristic features of aging skin, such as wrinkling, loss of elasticity, and atrophy, can largely be attributed to dermal changes. The amount of collagen in the skin decreases, while the cross linking increases, and the solubility of collagen is reduced. The total number of fibroblasts decreases, and their metabolism shows characteristic alterations. Some of the functions of fibroblasts in aging skin, such as the synthesis of protein and collagen, but also proliferation and chemotaxis, can be investigated by means of in vitro models. In addition, various syndromes of premature aging (e.g. progeria, Werner's syndrome) have proved useful models and have contributed considerably to the understanding of aging processes.
authors.affiliation: Dermatologische Klinik und Poliklink der Ludwig-Maximilians-Universität, München.
authors.forename: M
authors.initials: M
authors.lastname: Kulozik
authors.forename: T
authors.initials: T
authors.lastname: Krieg
mesh_terms: D000368:Aged; D003094:Collagen / Q000502:physiology*; D003238:Connective Tissue / Q000503:physiopathology; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D012867:Skin / Q000503:physiopathology; D015595:Skin Aging / Q000502:physiology*
chemical_list: D003094:Collagen
vernacular_title: Veränderungen des kollagenen Bindegewebes und der Fibroblasten während des Alterns.