[Recent knowledge of the structure and function of lactoferrin and ferritin].
A survey of recent knowledge on structure and importance of lactoferrin and ferritin is given. Lactoferrin is a symmetrically constructed glycoprotein which appears in the milk and in the body fluids and develops a bacteriostatic efficiency on account of the ability to Fe-binding together with other factors such as the IgA. In a particularly high concentration it is contained in the colostral milk of the woman. In the milk of the cattle the content is small. In the neutrophil granulocytes it is of importance for the functional ability in the phagocytosis. The ferritins are spherically constructed molecules which possess channels through which Fe-ions (up to 4,500 pro molecule) can be taken up or taken off. The ferritin content in the serum is correlated with the Fe-content of the liver and is dependent upon age as well as the Fe-supply. It decreases in Fe-deficiency: it increases in iron overload, in infectious diseases, in inflammation as well as in tumour development.
Kolb
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Wissenschaftsbereich Tierbiochemie, Karl-Marx-Universität Leipzig.
D000818:Animals; D005293:Ferritins / Q000502:physiology*; D006801:Humans; D007239:Infections / Q000276:immunology*; D007781:Lactoferrin / Q000502:physiology*; D007782:Lactoglobulins / Q000502:physiology*; D008895:Milk, Human / Q000276:immunology; D010587:Phagocytosis; D013329:Structure-Activity Relationship; D014168:Transferrin / Q000502:physiology
D007782:Lactoglobulins; D014168:Transferrin; D005293:Ferritins; D007781:Lactoferrin
Neuere Erkenntnisse zur Struktur und zur Funktion des Laktoferrins und des Ferritins.