The influence of insulin loading tests per os on insulin and glucose concentrations in blood of piglets within 40 hours from birth.
Experiments were conducted to elucidate the time required was showing in what time for postnatal absorption (within 40 hours from birth) and, occurrence of hypoglycaemic activity of exogenous insulin, when high concentrations of the hormone had been present in sow colostrum before parturition, 5 days after parturition, and, occasionally during lactation. The mean insulin concentration in piglet plasma samples from 11 litters amounted to 116.48 pmol/l +/- 101.11 (n = 115), and the glucose concentration was 4.69 pmol/l +/- 1.65 (n = 115), before insulin loading. Oral insulin loading (1.0 I.U./kg body weight) was applied to 10 litters. The piglet litters were separately tested, at different periods, 1, 2, 3, 5, 10, 15, 20, 25, 30, 40 hours after birth. After insulin loading, the mean hormone concentration in plasma samples increased to 447.11 pmol/l +/- 277.01 (n = 83) (P less than 0.001), and the glucose concentration dropped to 2.55 mmol/l +/- 1.08 (n = 83) (P less than 0.001). Insulin absorption from the alimentary tract to blood stopped completely in piglets of litters 10 and 11 examined in 30 and 40 hours after birth. 22 piglets had separated from litters Nos. 4 to 11 and were given intramuscularly injections of 1.0 I.U. insulin. The average hormone concentration in their plasma samples increased to 645.51 pmol/l +/- 44.2 (n = 22) (P less than 0.001), while their average glucose concentration dropped to 2.82 mmol/l +/- 0.13 (n = 22) (P less than 0.001). 24 piglets with hypoglycaemic symptoms from litters orally loaded with insulin and 1 piglet of the intramuscular group, were reanimated by intraperitoneal administration of glucose.(ABSTRACT TRUNCATED AT 250 WORDS)
Nowak
J
J
D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis*; D007328:Insulin / Q000008:administration & dosage / Q000097:blood*; D013552:Swine / Q000097:blood*
D001786:Blood Glucose; D007328:Insulin