The application of automated metaphase scanning to direct preparations of chorionic villi.
In order to increase the speed of analysis of metaphases from chorionic villi direct preparations, we have investigated the use of two automatic scanning devices, the Magiscan II and a version of Metafip (the research laboratory precursor of Cytoscan). The speed, efficiency, and ranking system have been compared to manual scanning. Results show that both machines detect approximately 80 per cent of the total analysable metaphases detected by a trained cytogeneticist. There appears to be reasonable agreement in ranking between methods.
Zahed
L
L
Division of Medical and Molecular Genetics, United Medical School of Guy's Hospital, London, U.K.
Murer-Orlando
M
M
Bobrow
M
M
D002824:Chorionic Villi / Q000166:cytology*; D015193:Chorionic Villi Sampling; D002875:Chromosomes / Q000032:analysis; D003936:Diagnosis, Computer-Assisted; D005260:Female; D006801:Humans; D007621:Karyotyping; D008677:Metaphase; D011247:Pregnancy