[Somatomedins: growth and differentiation factors. Clinical implications].
This review focuses on the action of somatomedins IGF-1 and IGF-2, and in particular the role of IGF-1 in cell multiplication and differentiation. A brief overview is given of the factors controlling IGF-1 flow rate expression in the tissues. Factors influencing IGF-1 plasma levels, i.e. age, and insufficiency or excess of growth hormone, are discussed.
Chatelain
P
P
INSERM U 307, hôpital Debrousse, Lyon, France.
Nicolino
M
M
De Parscau
L
L
Saez
J
J
Francois
R
R
D000375:Aging / Q000502:physiology; D002454:Cell Differentiation; D002455:Cell Division; D005260:Female; D013006:Growth Hormone / Q000502:physiology; D006801:Humans; D011247:Pregnancy; D011627:Puberty / Q000502:physiology; D011863:Radioimmunoassay; D013002:Somatomedins / Q000032:analysis / Q000235:genetics / Q000502:physiology*
D013002:Somatomedins; D013006:Growth Hormone
Somatomédines: facteurs de croissance et différenciation. Implications cliniques.