[What is the contribution of yeast genetics to tumor biology and tumor diagnosis?].
This short review article discusses methods and results of oncogene research in yeast. Current knowledge of the sequence, expression and biological function of ras-homologous genes of the yeast Saccharomyces cerevisiae is presented, as well as the implications of these findings for oncogene research in mammals. We review recent examples of highly conserved eukaryotic genes involved in growth control and mitosis control, including recent work from our own laboratories.
Breitenbach
M
M
Institut für Mikrobiologie und Genetik, Universität Wien.
Achatz
G
G
Heger
S
S
Hufnagl
P
P
Wallner
J
J
Eichler
M
M
Spevak
W
W
Schweiger
C
C
Rumpold
H
H
D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D011519:Proto-Oncogenes; D012441:Saccharomyces cerevisiae / Q000235:genetics*
D011518:Proto-Oncogene Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)
Welchen Beitrag leistet die Hefegenetik zur Tumorbiologie und Tumordiagnostik?