[Human monocytic colony-stimulating factor].
Human monocytic colony-stimulating factor (hM-CSF) is a glycoprotein which stimulates monocyte production in the bone marrow. It enhances CSF (such as G- and GM-CSF) production of monocytes and megakaryocyte-potentiating activity (Meg-POT). It also enhances tumor-killing activity of monocytes against several leukemic cell lines such as K562, U937, HL60 and Daudi. In the clinical studies, it was shown that hM-CSF infusions accelerated the recovery from neutropenia as well as thrombopenia after anticancer chemotherapy against hematological, gynecologic and urogenital malignancies. Human M-CSF infusions were tolerable without any serious side effects. It is reported that infusions of G-CSF and GM-CSF cause the increment of leukemic cell counts in some cases, but hM-CSF infusions did not increase leukemic cell counts. These results indicate that hM-CSF may be potentially useful for the treatment of myelosuppression induced by cancer chemotherapy in cancer patients.
Motoyoshi
K
K
Division of Hemopoiesis, Institute of Hematology, Jichi Medical School.
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D003115:Colony-Stimulating Factors / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007938:Leukemia / Q000473:pathology / Q000628:therapy*; D008297:Male; D009000:Monocytes / Q000276:immunology; D009503:Neutropenia / Q000139:chemically induced / Q000628:therapy; D010198:Pancytopenia / Q000139:chemically induced / Q000628:therapy; D014407:Tumor Cells, Cultured / Q000473:pathology
D000970:Antineoplastic Agents; D003115:Colony-Stimulating Factors