Effect of diabetes and insulin-induced hypoglycemia on hexokinase and glucose-6-phosphate dehydrogenase in red blood cells.
Activities of hexokinase and glucose-6-phosphate dehydrogenase have been measured in red blood cells from control, diabetic and insulin treated rats. After an initial decrease, the enzyme activities increased, but remained lower than control levels. A reversal of the diabetes effect was seen with insulin administration. Insulin induced hypoglycemia increased both enzymes. An overall control of glucose metabolism by insulin in red blood cells was observed.
Nehal
M
M
Hormone and Drug Research Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Baquer
N Z
NZ
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D006593:Hexokinase / Q000097:blood*; D006863:Hydrogen-Ion Concentration; D007003:Hypoglycemia / Q000139:chemically induced / Q000201:enzymology*; D007328:Insulin / Q000627:therapeutic use; D051381:Rats
D007328:Insulin; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase