title: [Clinical studies and sputum levels of ceftriaxone once daily administration in respiratory tract infection].
abstract: Ceftriaxone (CTRX), a new cephalosporin, was investigated by once daily administration for its clinical efficacy and safety on respiratory tract infections. The results obtained are summarized as follows: 1. Clinical responses to CTRX of a total of 39 cases with respiratory tract infections were excellent in 12 cases, good in 23, fair in 3, poor in 1 with an efficacy rate of 89.7%. Against acute bronchitis, lung abscess, bronchiectasis, chronic bronchitis and obstructive pneumonia, efficacy rates were 100%. 2. Serum levels and urinary excretion rates of CTRX were investigated in 2 cases after intravenous drip infusion of the drug at doses of 1 g and 2 g, respectively. Although urinary excretion rate tended to decrease with the deterioration of renal functions, prolongation of serum half-life was slight in those patients with normal liver function. In 1 case, it remained at 1.9 micrograms/ml at 12 hours and in another at 0.9 microgram/ml at 22 hours in sputum. According to the results, it appears that once daily administration of CTRX is effective and well tolerated in patients with acute respiratory infections.
authors.affiliation: Department of Internal Medicine, Hiroshima Prefectural Hiroshima Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Kuwabara
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: H
authors.initials: H
authors.lastname: Fukuhara
authors.forename: H
authors.initials: H
authors.lastname: Arita
authors.forename: T
authors.initials: T
authors.lastname: Inamizu
authors.forename: K
authors.initials: K
authors.lastname: Sadamoto
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Yamane
authors.forename: M
authors.initials: M
authors.lastname: Shigemoto
authors.forename: M
authors.initials: M
authors.lastname: Kawamoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002443:Ceftriaxone / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000378:metabolism; D013183:Sputum / Q000378:metabolism*
chemical_list: D002443:Ceftriaxone