title: [Development of chloroquine resistance in Plasmodium falciparum in Gabon between 1984 and 1987-88 (in vivo evaluation in a school environment)].
abstract: Unknown in 1980, suspected in 1983 and scarcely present in 1984-85, Plasmodium falciparum resistance to chloroquine as studied in vivo in schoolchildren in Gabon, has strongly developed in 4 years time. In 1987-88, administration of 25 mg/kg of chloroquine leaves one strain out of four with a parasitic load greater than 10/1.000 red blood cells examined by thick drop technique. The present, unfortunately provisional attitude tends to maintain chloroquine at efficient doses for as long as the resistant strains are ethically and practically controllable. The dispersion without strict control of new and for the time being very efficient drugs might rapidly give rise to a polychemoresistance which would leave us without defence.
authors.forename: D
authors.initials: D
authors.lastname: Richard-Lenoble
authors.forename: M
authors.initials: M
authors.lastname: Kombila
authors.forename: M
authors.initials: M
authors.lastname: Martz
authors.forename: B
authors.initials: B
authors.lastname: Lefèvre
authors.forename: J
authors.initials: J
authors.lastname: Chandenier
authors.forename: F
authors.initials: F
authors.lastname: Gay
authors.forename: X
authors.initials: X
authors.lastname: Billiault
authors.forename: M
authors.initials: M
authors.lastname: Thérizol-Ferly
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000494:pharmacology* / Q000627:therapeutic use; D004351:Drug Resistance; D005681:Gabon; D008288:Malaria / Q000188:drug therapy; D010963:Plasmodium falciparum / Q000187:drug effects*; D012424:Rural Population; D014505:Urban Population
chemical_list: D002738:Chloroquine
vernacular_title: Evolution de la résistance de Plasmodium falciparum à la chloroquine au Gabon entre 1984 et 1987-88 (evaluation in vivo en milieu scolaire).