Pathogenetic aspects of involutional osteoporosis.
The pathogenetic factors of postmenopausal and senile osteoporosis are reviewed. Both postmenopausal and senile osteoporosis occur as a result of a defective regulation of bone remodelling which leads to a negative uncoupling between bone resorption and bone formation. Systemic and local factors contribute to the development of the phenomenon. While studies of the systemic factors involved in age-related bone loss are well advanced, although still incomplete, the study of the local factors responsible at a tissue level for the negative skeletal balance has barely begun.
Mazzuoli
G F
GF
IV Patologia Medica, University of Rome La Sapienza, Italy.
D'Erasmo
E
E
Minisola
S
S
Tabolli
S
S
Bigi
F
F
Bianchi
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008593:Menopause / Q000502:physiology; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology* / Q000503:physiopathology