How safe and acceptable is cisapride?
Cisapride has not been found to have a significant frequency of adverse reactions, except for diarrhoea which occurs in about 4% of individuals taking the drug. Cisapride is devoid of antidopaminergic effects (i.e. no neuro-endocrine effects such as prolactin increase; no extrapyramidal reactions). Clinical laboratory data show no effect of cisapride on haematology, blood chemistry, liver and kidney function. It is concluded that cisapride has a favourable safety profile.
Bennett
J R
JR
Hull Royal Infirmary, England.
D000328:Adult; D002648:Child; D020117:Cisapride; D002986:Clinical Trials as Topic; D005500:Follow-Up Studies; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008787:Metoclopramide / Q000009:adverse effects; D010880:Piperidines / Q000009:adverse effects* / Q000627:therapeutic use; D012702:Serotonin Antagonists / Q000009:adverse effects* / Q000627:therapeutic use
D010880:Piperidines; D012702:Serotonin Antagonists; D008787:Metoclopramide; D020117:Cisapride