title: Insulin as a vasodilating agent in the first hour after cardiopulmonary bypass.
abstract: To study the vasodilating effect of insulin after termination of ECC in aortocoronary bypass surgery, 21 patients were randomized to treatment with 7.5 U of fast-acting insulin/kg b.w. as a bolus injection followed by continuous infusion of 15 U/kg b.w. for 1 hour, or to serve as controls. Insulin administration was begun when the last proximal anastomosis had been completed. Cardiac output and central pressures were monitored for 1 hour after termination of ECC. Systemic vascular resistance in both groups was lower at the end of ECC than before surgery (reduction 39% in the controls, 51% in the insulin-treated group). During the following hour the peripheral resistance increased significantly in the controls (from 20 +/- 2 to 29 +/- 2 mmHg X min X m2/l), but no change was found in the insulin group. It is concluded that insulin can maintain a low vascular resistance after aortocoronary bypass surgery.
authors.affiliation: Department of Thoracic Surgery, Sahlgrenska Hospital, Gothenburg, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Svensson
authors.forename: R
authors.initials: R
authors.lastname: Ekroth
authors.forename: F
authors.initials: F
authors.lastname: Nilsson
authors.forename: J
authors.initials: J
authors.lastname: Pontén
authors.forename: G
authors.initials: G
authors.lastname: William-Olsson
mesh_terms: D000328:Adult; D000368:Aged; D002315:Cardiopulmonary Bypass; D002986:Clinical Trials as Topic; D006439:Hemodynamics; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013997:Time Factors; D014655:Vascular Resistance; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D007328:Insulin; D014665:Vasodilator Agents