[Immunologic assessment of preparations of the RS virus at the stages of its purification and concentration].
The work demonstrates the immunogenic potency of some preparations of RS virus, differing in the degree of their purification and introduced by multiple intranasal administration. The immunogenic potency of these preparations was manifested by the synthesis of antibodies determined in the coagglutination test (the specificity of these antibodies was confirmed in the reaction of the neutralization of RS virus), as well as by sensitization determined in the leukocyte migration inhibition test. Immunization with concentrated virus was more effective than immunization with the preparation of virion fraction. The intranasal administration of live RS virus to mice induced the appearance of a morphologically determined disease which was not prevented by the development of immune response accompanying the disease. The conclusion was made that further improvement in the system of testing the preparations of RS virus was necessary.
Chizhevskaia
M a
Ma
Liashenko
V A
VA
Drozhennikov
V A
VA
Shanin
S S
SS
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002464:Cell Migration Inhibition; D004306:Dose-Response Relationship, Immunologic; D007114:Immunization; D007124:Immunoenzyme Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D009500:Neutralization Tests; D012136:Respiratory Syncytial Viruses / Q000276:immunology* / Q000302:isolation & purification / Q000528:radiation effects; D010253:Respirovirus Infections / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D013997:Time Factors; D014466:Ultraviolet Rays; D014776:Virus Cultivation
D000914:Antibodies, Viral
Immunologicheskaia otsenka preparatov RS-virusa na étapakh ego ochistki i kontsentratsii.