title: Evaluation of cilofungin (LY121019) for treatment of experimental Candida albicans endocarditis in rabbits.
abstract: The efficacy of cilofungin (LY121019) for aortic valve endocarditis caused by Candida albicans in rabbits was studied. Vegetation titers were similar for cilofungin-treated and untreated rabbits. No rabbit survived beyond 5 days in either group. All rabbits given amphotericin B survived, and titers were reduced. Cilofungin was ineffective in this model.
authors.affiliation: Medical Service, San Francisco General Hospital, California.
authors.forename: A
authors.initials: A
authors.lastname: Padula
authors.forename: H F
authors.initials: HF
authors.lastname: Chambers
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001021:Aortic Valve; D002176:Candida albicans; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D054714:Echinocandins; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology; D006207:Half-Life; D006349:Heart Valve Diseases / Q000188:drug therapy / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000627:therapeutic use; D010456:Peptides, Cyclic; D011817:Rabbits
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D010455:Peptides; D010456:Peptides, Cyclic; D000666:Amphotericin B; C042101:cilofungin