title: [Leukinferon in the combined therapy of infection in neonates and infants].
abstract: Leikinferon was used in multimodality treatment of sepsis caused by gram-negative microorganisms and staphylococci in 33 neonates and infants. It was injected in a dose of 10,000 IU and was given in courses of 4-6 intramuscular administrations with an interval of 48 hours. The treatment with leikinferon promoted a steady improvement of the clinical status, associated with pronounced activation of the interferon system and neutrophilic phagocytosis. The use of the drug in septic shock did not produce any noticeable affect. Fever was the only side effect induced by drug administration. In some children, the temperature rose by 1-1.5 degrees C. It returned to normal after 10-14 hours.
authors.forename: G I
authors.initials: GI
authors.lastname: Nizharadze
authors.forename: V P
authors.initials: VP
authors.lastname: Kuznetsov
authors.forename: A Sh
authors.initials: ASh
authors.lastname: Gamkhitashvili
authors.forename: K G
authors.initials: KG
authors.lastname: Chitaishvili
authors.forename: I V
authors.initials: IV
authors.lastname: Pavlenishvili
mesh_terms: D000367:Age Factors; D001424:Bacterial Infections / Q000276:immunology / Q000628:therapy*; D004338:Drug Combinations; D004756:Enterobacteriaceae Infections / Q000276:immunology / Q000628:therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007370:Interferon Type I / Q000627:therapeutic use*; D008297:Male; D012706:Serratia marcescens; D013203:Staphylococcal Infections / Q000276:immunology / Q000628:therapy; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D007370:Interferon Type I
vernacular_title: Leĭkinferon v kompleksnom lechenii sepsisa u novorozhdennykh i u deteĭ grudnogo vozrasta.