Effects of dihydroergotamine on psychomotor function, neuroendocrine parameters and blood pressure, in healthy volunteers.
Following the infusion of 15 micrograms/kg of dihydroergotamine (DHE) a 50-fold rise in growth hormone plasma levels was observed in 9 healthy volunteers. Prolactin (PRL) secretion was depressed 240 minutes post infusion. For 170 min, diastolic blood pressure was increased reaching a peak of +19 mmHg at the end of the infusion. Mild sedation and nausea were induced by the treatment for a total duration of 60 min.
Danjou
P
P
Service de Pharmacologie, Division Ambroise Paré, Hôpital de la Salpêtrière, Paris, France.
Lacomblez
L
L
Warot
D
D
Puech
A J
AJ
D000328:Adult; D000339:Affect / Q000187:drug effects; D001143:Arousal / Q000187:drug effects*; D001288:Attention / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D002986:Clinical Trials as Topic; D004087:Dihydroergotamine / Q000493:pharmacokinetics / Q000494:pharmacology*; D004311:Double-Blind Method; D005425:Flicker Fusion / Q000187:drug effects; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D011388:Prolactin / Q000097:blood*; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects
D004087:Dihydroergotamine; D011388:Prolactin; D013006:Growth Hormone; D009638:Norepinephrine