Plasma homocysteine and methionine tolerance in early-onset vascular disease.
In three different studies we tested the hypothesis that early-onset vascular disease is associated with impaired homocysteine metabolism which could contribute to the development of arteriosclerosis and thrombosis. In patients with occlusive vascular disease before the age of 60, a post-methionine load increase of plasma homocysteine exceeding the highest value for comparable healthy control subjects was found in 1 of 21 with myocardial infarction (5%), 14 of 37 with aorto-iliac disease (38%), and 17 of 53 with cerebrovascular disease (32%). This might indicate heterozygosity for homocystinuria due to cystathionine beta-synthase deficiency. Concentrations of serum vitamin B12 and red cell folate had an important modulating effect on plasma homocysteine concentrations in the fasting state.
Brattström
L
L
Department of Neurology, University Hospital, Lund, Sweden.
Israelsson
B
B
Hultberg
B
B
D004361:Drug Tolerance; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008715:Methionine / Q000493:pharmacokinetics*; D012307:Risk Factors; D014652:Vascular Diseases / Q000097:blood*
D006710:Homocysteine; D008715:Methionine