Comparative efficacy of terbutaline administered by Nebuhaler and by nebulizer in young children with acute asthma.
We compared the use of terbutaline sulphate that was delivered by a nebulizer with its delivery by a Nebuhaler at two dose levels in 27 children (nine children per group) of between three and six years of age with acute asthma. No significant difference was found in the mean baseline clinical score among the three groups, and a significant decline occurred in the mean clinical scores in all groups by 15 minutes which was maintained to 60 minutes after the dose was administered. The decline that was achieved with delivery of the drug by way of a Nebuhaler (at either dose level) was not significantly different from that with a nebulizer, although cooperation with Nebuhaler usage was not universal in the age-group.
Pendergast
J
J
Department of Respiratory Medicine, Children's Hospital Camperdown, NSW.
Hopkins
J
J
Timms
B
B
Van Asperen
P P
PP
D000208:Acute Disease; D000336:Aerosols; D000704:Analysis of Variance; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D009330:Nebulizers and Vaporizers; D011897:Random Allocation; D012720:Severity of Illness Index; D013726:Terbutaline / Q000008:administration & dosage* / Q000627:therapeutic use; D013997:Time Factors
D000336:Aerosols; D003692:Delayed-Action Preparations; D013726:Terbutaline