Usefulness of nifedipine for myocardial ischemia and the nifedipine gastrointestinal therapeutic system.
Although conventional treatment of angina pectoris with nifedipine capsules involves frequent daily dosing, a new vehicle for the once-daily delivery of this potent but insoluble calcium channel blocking agent has been developed. With the gastrointestinal therapeutic system (GITS) formulation, constant effective drug levels of nifedipine are delivered for a full 24-hour period. When nifedipine GITS 30, 60 or 90 mg was administered once daily to patients with stable angina pectoris taking beta blockers, clinical effectiveness was demonstrated both by an increase in time to angina and by exercise time compared with placebo. Improvement was noted to be more significant with the higher doses of nifedipine administered once daily. This study indicates that nifedipine GITS provides additional antianginal protection in patients with exercise-induced angina secondary to coronary artery disease who are receiving a fixed dose of beta blocker.
Bittar
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Section of Cardiology, University of Wisconsin, Madison.
D000787:Angina Pectoris / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D003327:Coronary Disease / Q000150:complications*; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004562:Electrocardiography; D005080:Exercise Test; D006801:Humans; D015337:Multicenter Studies as Topic; D009543:Nifedipine / Q000008:administration & dosage* / Q000097:blood
D003692:Delayed-Action Preparations; D009543:Nifedipine