title: The logical structure and validity of experimental designs in pharmacokinetics and clinical pharmacology.
abstract: Much of the literature on research design in clinical pharmacology and pharmacokinetics emphasizes statistical concerns, thus suggesting that a primary ingredient of a valid research design is an appropriate plan for statistical analysis of data. However, statistical validity is only one of several ways to evaluate an experimental study. The present paper reviews the underlying logic and sources of invalidity of experimental drug research suggesting influences and factors which may deceive or lure an experimenter into erroneous conclusions.
authors.affiliation: Department of Educational & Counseling Psychology, University of Kentucky, Lexington.
authors.forename: E J
authors.initials: EJ
authors.lastname: Mason
authors.forename: M
authors.initials: M
authors.lastname: Bialer
mesh_terms: D008954:Models, Biological; D010599:Pharmacokinetics; D010600:Pharmacology; D012107:Research Design