[Assessment of tolerability and antihypertensive efficacy of aceplus mite (captopril (CPT) 50 mg + hydrochlorothiazide (HCTZ) 15 mg): a double-blind study vs. HCTZ in diabetic hypertensive patients. A report on three treatments].
Thirty hypertensive diabetic patients were randomly, double blindly, treated with Captopril (CPT) 50 mg + hydrochlorothiazide (HCTZ) 15 mg (No 19) or HCTZ 25 mg alone (No 11) for 3 months, to assess blood pressure control and some metabolic modifications. The results indicate that CPT + a low dose of HCTZ maintains the synergistic effect of the two drugs, minimizing the metabolic problems related to HCTZ in hypertensive diabetic patients.
Santucci
A
A
De Cesaris
R
R
Buoninconti
R
R
Botta
G F
GF
D000328:Adult; D000368:Aged; D002216:Captopril / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D048909:Diabetes Complications; D004311:Double-Blind Method; D004338:Drug Combinations; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D011897:Random Allocation
D004338:Drug Combinations; D006852:Hydrochlorothiazide; D002216:Captopril
Valutazione della sicurezza, tollerabilità ed efficacia anti-ipertensiva dell'aceplus mite [captopril (CPT) 50 mg + idroclorotiazide (HCTZ) 15 mg]: studio in doppio cieco vs. HCTZ in pazienti diabetici ipertesi. Rapporto a 3 mesi di trattamento.