title: [Bacteriological investigation on an outbreak of acute enteritis associated with verotoxin-producing Escherichia coli O111:H-].
abstract: An outbreak of acute enteritis in children aged one to thirty-three months occurred from June 10th to 23rd, 1986, at a private orphanage in Matsuyama City. Twenty-two out of 23 children suffered from diarrhea. Nine of the 22 children excreted bloody stool. Fever and vomiting were observed with a few patients. One of them, a 33-month-old girl, developed hemolytic uremic syndrome, and died twelve days after the admission. Escherichia coli O111:H- was isolated from fecal specimens of 7 out of 15 patients. The culture filtrate of the isolate caused fluid accumulation in ligated ileal loops in a rabbit, and was lethal to mice. It was found that all isolates produced two kinds of Vero toxins (VT1 and VT2, or shiga-like toxin I and II). The amount of VT2 produced in vitro was about 10 times more than that of VT1.
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Ohseto
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: N
authors.initials: N
authors.lastname: Shinohara
authors.forename: H
authors.initials: H
authors.lastname: Inoue
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kakihara
authors.forename: T
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: T
authors.initials: T
authors.lastname: Yutsudo
authors.forename: Y
authors.initials: Y
authors.lastname: Oku
mesh_terms: D000208:Acute Disease; D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis* / Q000276:immunology / Q000633:toxicity; D002675:Child, Preschool; D004196:Disease Outbreaks; D004751:Enteritis / Q000453:epidemiology / Q000209:etiology*; D004926:Escherichia coli / Q000378:metabolism*; D004927:Escherichia coli Infections; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D051379:Mice; D011817:Rabbits; D022622:Shiga Toxin 1
chemical_list: D001427:Bacterial Toxins; D022622:Shiga Toxin 1