[The effect of almagel, gastrotsepin and food on the acidity and protease activity of the stomach and duodenum in peptic ulcer].
Patients with duodenal ulcers were examined for the degree and duration of the effect of almagel, gastrocepin and food on pH and protein digestion by various enzymes of the contents of the stomach and initial part of the duodenum. Acidity and protein digestion were determined in vitro with 3 values of the substrate pH. It was established that almagel and food efficiently reduced the acidity and protein digestion in the stomach and duodenum. Gastrocepin decreased those indicators to a lesser degree but throughout a longer period of time. The data obtained can be used for optimizing the treatment of patients suffering from duodenal ulcers.
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Grigor'eva
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IN
D000536:Aluminum Hydroxide / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001566:Benzocaine / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D004341:Drug Evaluation; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000201:enzymology; D004386:Duodenum / Q000201:enzymology*; D005215:Fasting; D005502:Food; D005745:Gastric Acidity Determination; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000627:therapeutic use*; D008276:Magnesium Hydroxide / Q000627:therapeutic use*; D008297:Male; D010447:Peptide Hydrolases / Q000378:metabolism*; D010890:Pirenzepine / Q000627:therapeutic use*; D013270:Stomach / Q000201:enzymology*; D013997:Time Factors
D000897:Anti-Ulcer Agents; D004338:Drug Combinations; C010016:aluminum hydroxide, benzocaine, magnesium hydroxide drug combination; D010890:Pirenzepine; D000536:Aluminum Hydroxide; D010447:Peptide Hydrolases; D008274:Magnesium; D008276:Magnesium Hydroxide; D001566:Benzocaine
Vliianie al'magelia, gastrotsepina i pishchi na kislotnost' i aktivnost' proteaz v zheludke i dvenadtsatiperstnoĭ kishke pri iazvennoĭ bolezni.