title: [Fibrodysplasia ossificans progressiva or Münchmeyer's disease].
abstract: Fibrodysplasia ossificans progressiva is a heritable and generalized disorder of connective tissue, characterized by the appearance of bony tissue within the striated muscles, tendons and ligaments; moreover, some skeletal abnormalities may also occur, mainly microdactyly of the big toes. This is a very rare disease, which presents in early life; its course is unavoidably progressive, producing a sort of petrifaction of the patient some years after the first symptoms. It is defined as an autosomal dominant trait, being due in most cases to a new mutation. At present no known treatment is available to stop the course of the disease, but sometimes disodium etidronate may be effective in preventing calcification of heterotopic bony tissue.
authors.forename: G
authors.initials: G
authors.lastname: Galvagno
authors.forename: L
authors.initials: L
authors.lastname: Marchi
authors.forename: D
authors.initials: D
authors.lastname: Manachino
authors.forename: V
authors.initials: V
authors.lastname: Biarese
authors.forename: P
authors.initials: P
authors.lastname: Lovisetto
mesh_terms: D006801:Humans; D009221:Myositis Ossificans
vernacular_title: La fibrodisplasia ossificante progressiva o malattia di Münchmeyer.