Effect of salt-loading on erythrocyte deformability in spontaneously hypertensive and Wistar-Kyoto rats.
Effects of salt-loading on erythrocyte and erythrocyte ghost deformabilities were measured by laser diffractometry using a flat cell and a helium-neon laser in spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY). Salt-loading did not affect the deformability of erythrocytes in SHR and WKY, although a significantly reduced deformability was observed in salt-loaded SHR compared with values in control WKY and salt-loaded WKY (p less than 0.05, p less than 0.05, respectively). In contrast, salt-loading significantly reduced the deformability of erythrocyte ghosts in WKY and SHR (p less than 0.05, p less than 0.05, respectively). Our results suggest that salt-loading reduces erythrocyte membrane viscoelasticity in both WKY and SHR, and that the observed reduction of ghost deformability induced by salt-loading may influence the peripheral circulation.
Murakawa
K
K
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Kohno
M
M
Yasunari
K
K
Yokokawa
K
K
Kurihara
N
N
Nagasawa
T
T
Kinoshita
Y
Y
Takeda
T
T
D000818:Animals; D003584:Cytological Techniques; D004907:Erythrocyte Deformability / Q000187:drug effects*; D006973:Hypertension / Q000097:blood*; D007834:Lasers; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012965:Sodium Chloride / Q000494:pharmacology*
D012965:Sodium Chloride