[Biosynthesis of oleandomycin by cultures of Streptomyces antibioticus obtained after regeneration and fusion of protoplasts].
The ability of Streptomyces antibioticus strains to synthesize oleandomycin is studied under the effect of regeneration and fusion of protoplasts. The production of strains-regenerants with an increased (by 30-50%) synthesis of oleandomycin is possible. Regenerants of mutants resistant to the proper antibiotic retain a high level of the oleandomycin synthesis more stably. Variations in the antibiotic-production ability are considered in regenerant populations of various generations.
Shevchenko
A A
AA
Matseliukh
B P
BP
Sobachkina
I S
IS
Tyshchenko
A F
AF
Orekhova
V M
VM
D009827:Oleandomycin / Q000096:biosynthesis*; D011523:Protoplasts; D013302:Streptomyces / Q000378:metabolism*; D013303:Streptomyces antibioticus / Q000378:metabolism*
D009827:Oleandomycin
Biosintez oleandomitsina kul'turami Streptomyces antibioticus, poluchennymi posle regeneratsii i sliianiia protoplastov.