title: Self non self discrimination within the immune system: a view from the bridge.
abstract: The author reviews the actual concepts on the mechanisms of self-tolerance. He underlines the complexity and the complementarity of the different phenomenons of clonal deletion, clonal anergy and suppression. In addition, he proposes a new theory on the generation of the immune repertoires based on the presentation of self-antigens by particular antigen-presenting cells, the self-presenting cells.
authors.affiliation: Département de Biologie Moléculaire, Université Libre de Bruxelles, Rhode Saint Genèse.
authors.forename: J
authors.initials: J
authors.lastname: Urbain
authors.forename: G
authors.initials: G
authors.lastname: Urbain-Vansanten
authors.forename: D
authors.initials: D
authors.lastname: De Wit
mesh_terms: D001324:Autoantigens / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001324:Autoantigens