Tranylcypromine in depression resistant to cyclic antidepressions.
1. Non-responders to cyclic antidepressants were treated with the MAO-inhibitor tranylcypromine in two studies: the first study in an open comparison with L-5-hydroxytryptophan (L-5HTP), the second study in a double blind comparison with nomifensine. 2. While both L-5HTP and nomifensine appeared to be ineffective, tranylcypromine was effective in 26 out of 45 patients. 3. It is concluded that besides ECT also MAO-inhibitors such as tranylcypromine are an effective alternative for depressed patients not responding to cyclic antidepressants.
Nolen
W A
WA
Department of Biological Psychiatry, Psychiatric Centre Bloemendaal, The Hague, The Netherlands.
D006916:5-Hydroxytryptophan / Q000627:therapeutic use*; D000328:Adult; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009627:Nomifensine / Q000627:therapeutic use*; D014191:Tranylcypromine / Q000627:therapeutic use*
D009627:Nomifensine; D014191:Tranylcypromine; D006916:5-Hydroxytryptophan