title: Role of growth factors in inflammation and repair.
abstract: Mononuclear cells generate a variety of hormone-like proteins termed growth factors that are instrumental in the evolution and resolution of inflammatory reactions. Many of these growth regulatory molecules have multifunctional properties. For example, the mononuclear cell-derived growth factors, platelet-derived growth factor (PDGF), and transforming growth factor beta (TGF-beta), are potent leukocyte chemoattractants. In addition, TGF-beta, a product of platelets, T lymphocytes, and monocytes, appears to induce the transcription of other monocyte-derived growth hormone genes. In this regard, picomolar concentrations of TGF-beta stimulate peripheral blood monocytes to transcribe the genes for PDGF (c-sis), basic fibroblast growth factor (FGF), interleukin 1 (IL-1), and tumor necrosis factor (TNF). Furthermore, levels of mRNA for TGF-beta, which is constitutively expressed in resting monocytes, are also increased by exogenous TGF-beta. Each of these monocyte products exhibits a plethora of biological activities on other cell types. T lymphocytes, in response to antigen, contribute to this network by secreting growth factors and lymphokines that regulate monocyte growth factor production.
authors.affiliation: Cellular Immunology Section, National Institute of Dental Research, Bethesda, Maryland 20892.
authors.forename: S M
authors.initials: SM
authors.lastname: Wahl
authors.forename: H
authors.initials: H
authors.lastname: Wong
authors.forename: N
authors.initials: N
authors.lastname: McCartney-Francis
mesh_terms: D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D014945:Wound Healing
chemical_list: D006133:Growth Substances