title: Increased insulin secretion in subjects with impaired glucose tolerance.
abstract: In order to assess the relative roles of insulin deficiency and insulin resistance in the pathogenesis of impaired glucose tolerance (IGT), simultaneous measurement of serum immunoreactive insulin (IRI) and serum immunoreactive C-peptide (IRC) responses during 75 g oral glucose tolerance test were performed in 44 normal-weight adults with IGT (27 men, mean age +/- SEM = 46.1 +/- 1.9 year; 17 women, aged 49.1 +/- 3.3 year) and 44 control subjects (27 men, aged 45.5 +/- 2.1 year; 17 women, aged 47.9 +/- 3.0 year). Subjects with IGT had consistently higher 120-m IRI levels in comparison to corresponding age, sex, and BMI-matched control subjects, i.e. mean +/- SEM = 118.8 +/- 13.7 vs 57.0 +/- 6.9 microU/ml (male, P = 0.0002), and 116.3 +/- 11.8 vs 43.3 +/- 5.8 microU/ml (female, P = 0.0000). Similarly, 120-m IRC levels were higher in subjects with IGT, i.e. 2.12 +/- 0.26 vs 1.35 +/- 0.15 pmol/ml (male, P = 0.0262), and 3.13 +/- 1.01 vs 1.54 +/- 0.19 pmol/ml (female, P = 0.0080). Our findings indicate that increased insulin secretion is present in subjects with IGT, suggesting that insulin resistance is the predominant factor in the pathogenesis of IGT.
authors.forename: G
authors.initials: G
authors.lastname: Puavilai
authors.forename: S
authors.initials: S
authors.lastname: Pensuwan
authors.forename: V
authors.initials: V
authors.lastname: Tiewtranon
authors.forename: A
authors.initials: A
authors.lastname: Sriphrapradang
authors.forename: V
authors.initials: V
authors.lastname: Supitak
authors.forename: S
authors.initials: S
authors.lastname: Chanprasertyotin
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010179:Pancreas / Q000166:cytology
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin