Crystal structure determination of 4-zinc bovine insulin at 1.9 A resolution.
With the isomorphous difference Fourier method and the restrained least-squares refinement technique, the crystal structure of 4-zinc bovine insulin in space group R3 was determined. The final crystallographic residual is 0.19 at 1.9 A resolution. Based on the refined model, the structural mechanism for prolonged action of 4-zinc insulin is discussed.
Li
M
M
Institute of Biophysics, Academia Sinica, Beijing, PRC.
Wang
D C
DC
Liang
D C
DC
D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D003460:Crystallization; D003692:Delayed-Action Preparations; D007328:Insulin / Q000032:analysis*; D008968:Molecular Conformation; D015032:Zinc / Q000032:analysis*
D003692:Delayed-Action Preparations; D007328:Insulin; D015032:Zinc