title: [Physiologic significance of "stringent control" in Escherichia coli under extreme starvation].
abstract: The viability of three isogenic relA+/relA strain pairs of Escherichia coli (CP78/CP79; NF161/NF162; CP107/CP143) was studied during prolonged starvation for amino acids, glucose or phosphate. After amino acid limitation we found a prolonged viability of all relA+ strains which synthesized ppGpp. We suggest that some ppGpp-mediated pleiotropic effects of the stringent response (e.g. glykogen accumulation, enhanced protein turnover) might be involved in this prolongation of survival. After glucose or phosphate starvation there was no difference in the relA+/relA strains either in the ppGpp content or in the survival.
authors.affiliation: Sektion Biologie der Ernst-Moritz-Arndt-Universität, Greifswald, Deutsche Demokratische Republik.
authors.forename: H
authors.initials: H
authors.lastname: Mach
authors.forename: M
authors.initials: M
authors.lastname: Hecker
authors.forename: I
authors.initials: I
authors.lastname: Hill
authors.forename: A
authors.initials: A
authors.lastname: Schroeter
authors.forename: F
authors.initials: F
authors.lastname: Mach
mesh_terms: D004926:Escherichia coli / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure; D006159:Guanosine Tetraphosphate / Q000378:metabolism; D007700:Kinetics; D008854:Microscopy, Electron; D013045:Species Specificity
chemical_list: D006159:Guanosine Tetraphosphate
vernacular_title: Physiologische Bedeutung der "Stringent Control" bei Escherichia coli unter extremen Hungerbedingungen.