Relapse of gastric ulcers after healing with omeprazole and cimetidine. A double-blind follow-up study. Danish Omeprazole Study Group.
Two hundred and seventeen gastric ulcer patients whose ulcers had healed during omeprazole (30 mg) or cimetidine (1 g) treatment entered a follow-up study for 6 months. Endoscopy was performed after 6 months, or earlier if the patient had a symptomatic relapse. Both the initial treatment and the follow-up study were double-blind. Ulcers recurred in 35% of the omeprazole-treated patients and in 41% of the cimetidine-treated patients (p greater than 0.05; log-rank test). The recurrence rate was 45% among smokers, compared with 25% among non-smokers (p less than 0.05). Ulcers also recurred more rapidly (p less than 0.05) in patients with a healed prepyloric ulcer (49%) than in patients with a healed corpus ulcer (23%).
D000293:Adolescent; D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*; D012008:Recurrence; D012907:Smoking; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000473:pathology
D002927:Cimetidine; D009853:Omeprazole