title: Methylprednisolone versus metoclopramide as antiemetic treatment in patients receiving adjuvant cyclophosphamide, methotrexate, 5-fluorouracil (CMF) chemotherapy: a randomized crossover blind study.
abstract: Nineteen women receiving their first cycle of adjuvant chemotherapy for early breast cancer were randomized between two antiemetic drugs: methylprednisolone (MPN) 125mg and metoclopramide (MCP) 20mg, both given by intravenous push as a single dose. The chemotherapy included: cyclophosphamide, methotrexate and 5-fluorouracil (CMF). The total response rates for MPN and MCP were: complete protection 11% versus 0% and partial protection 63% versus 11% of the patients, respectively (P = 0.007). Eighteen patients (95%) preferred MPN over MCP. Common side effects with both drugs were: drowsiness, headache and diarrhea. MPN is recommended as an antiemetic in patients receiving CMF adjuvant chemotherapy.
authors.affiliation: Department of Oncology, Sharett Institute, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Gez
authors.forename: A
authors.initials: A
authors.lastname: Sulkes
authors.forename: L
authors.initials: L
authors.lastname: Ochayon
authors.forename: C
authors.initials: C
authors.lastname: Gera
authors.forename: S
authors.initials: S
authors.lastname: Nathan
authors.forename: Y
authors.initials: Y
authors.lastname: Cass
authors.forename: E
authors.initials: E
authors.lastname: Rubello
authors.forename: S
authors.initials: S
authors.lastname: Biran
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D003520:Cyclophosphamide / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects; D008775:Methylprednisolone / Q000627:therapeutic use*; D008787:Metoclopramide / Q000627:therapeutic use*; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D003520:Cyclophosphamide; D008787:Metoclopramide; D005472:Fluorouracil; D008775:Methylprednisolone; D008727:Methotrexate