title: Functional evolutionary divergence of proteolytic enzymes and their inhibitors.
abstract: The amino acid residues of protease inhibitors that interact directly with proteases are hypervariable, suggesting recent positive evolutionary selection for functional differences between them. A similar hypervariability is apparent in some proteases, which may be co-evolving with the inhibitors.
authors.forename: T E
authors.initials: TE
authors.lastname: Creighton
authors.forename: N J
authors.initials: NJ
authors.lastname: Darby
mesh_terms: D000818:Animals; D001665:Binding Sites; D005075:Biological Evolution; D005796:Genes; D014644:Genetic Variation; D006801:Humans; D010447:Peptide Hydrolases / Q000235:genetics* / Q000378:metabolism; D011480:Protease Inhibitors / Q000378:metabolism; D011487:Protein Conformation; D012641:Selection, Genetic
chemical_list: D011480:Protease Inhibitors; D010447:Peptide Hydrolases