Blood pressure response to norepinephrine and angiotensin II in the offspring of parathyroidectomized mother rats.
1. The basal blood pressure and the drug-stimulated pressor response were studied in male offspring in the sixth generation (5d-PTx-F6) of rats parathyroidectomized on day 5 of pregnancy. 2. The systolic blood pressure in conscious 5d-PTx-F6 rats measured by a tail cuff was significantly higher (P less than 0.001) than in control rats. 3. Venous plasma renin activity was significantly lower (P less than 0.001) in the 5d-PTx-F6 rats. Plasma levels of calcium, sodium, and potassium in the 5d-PTx-F6 rats and in the controls did not differ. 4. Systolic arterial pressure response to intravenously (i.v.) administered angiotensin II (150 ng/kg) in the 5d-PTx-F6 rats was significantly greater than in the controls (P less than 0.05), when blood pressure was measured directly through a pressure transducer under anaesthesia. 5. Pressor responses to norepinephrine (5 micrograms/kg, i.v.) in the 5d-PTx-F6 rats were significantly lower (P less than 0.05) than in the controls, when blood pressure was measured directly under anaesthesia. 6. The findings suggest that the 5d-PTx-F6 rats undergo functional alterations of the renin-angiotensin and sympathetic nervous systems for cardiovascular regulations.
Nakanishi
H
H
Department of Pharmacology, Teiko University School of Medicine, Tokyo, Japan.
Fujii
T
T
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010280:Parathyroid Glands / Q000502:physiology*; D011188:Potassium / Q000097:blood; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood
D000804:Angiotensin II; D012964:Sodium; D012083:Renin; D011188:Potassium; D002118:Calcium; D009638:Norepinephrine