title: [Significance of endothelin in shock pathogenesis].
abstract: Endothelin is a recently discovered bioactive peptide produced by vascular endothelial cells. By means of specific radioimmunoassay we found that plasma endothelin level in patients with late septic shock was significantly increased. And a typical shock model in healthy rats was reproduced by continuous infusion of endothelin (endothelin shock). Infusion of endothelin at a small dose to hemorrhagic shocked rats deteriorated the shock process and resulted in an irreversible development. From these results it is suggested that endothelin may be an endogenous injury-inducing factor, acting as one of the important humoral factors involved in shock pathogenesis.
authors.forename: C S
authors.initials: CS
authors.lastname: Tang
authors.forename: X Z
authors.initials: XZ
authors.lastname: Xie
authors.forename: Z P
authors.initials: ZP
authors.lastname: Li
authors.forename: C Y
authors.initials: CY
authors.lastname: Li
authors.forename: Z E
authors.initials: ZE
authors.lastname: Song
authors.forename: L
authors.initials: L
authors.lastname: Shao
authors.forename: J
authors.initials: J
authors.lastname: Tang
authors.forename: J Y
authors.initials: JY
authors.lastname: Su
mesh_terms: D000818:Animals; D001794:Blood Pressure; D016232:Endothelins; D006801:Humans; D008297:Male; D010455:Peptides / Q000097:blood* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000188:drug therapy; D012772:Shock, Septic / Q000097:blood* / Q000209:etiology
chemical_list: D016232:Endothelins; D010455:Peptides