title: Postoperative active-specific immunotherapy of lymph node micrometastasis in a guinea pig tumor model.
abstract: Strain 2 guinea pigs bearing the transplanted intradermally growing line 10 tumor underwent surgical tumor excision at a time when the tumor had already metastasized to the first draining lymph node. Postoperative active-specific immunotherapy (ASI) consisted of two vaccinations with either Newcastle disease virus (NDV) modified or BCG-admixed line 10 tumor cells. 32% of the animals were cured of residual lymphatic micrometastasis by ASI with NDV-modified tumor cells while ASI with BCG was successful in 45%. No synergistic effect was observed when both ASI procedures were combined. Vaccine preparations with mitomycin C inactivated tumor cells proved to be less (NDV) or noneffective (BCG) compared to those with irradiated tumor cells.
authors.affiliation: Department of Otorhinolaryngology, Klinikum Mannheim, FRG.
authors.forename: H
authors.initials: H
authors.lastname: Bier
authors.forename: G
authors.initials: G
authors.lastname: Armonat
authors.forename: J
authors.initials: J
authors.lastname: Bier
authors.forename: V
authors.initials: V
authors.lastname: Schirrmacher
authors.forename: U
authors.initials: U
authors.lastname: Ganzer
mesh_terms: D000818:Animals; D002460:Cell Line / Q000276:immunology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D007110:Immunity, Active; D007167:Immunotherapy / Q000379:methods*; D008114:Liver Neoplasms, Experimental / Q000276:immunology / Q000601:surgery / Q000628:therapy*; D008207:Lymphatic Metastasis; D009163:Mycobacterium bovis / Q000276:immunology; D009522:Newcastle disease virus / Q000276:immunology; D011184:Postoperative Period; D014407:Tumor Cells, Cultured / Q000276:immunology