title: [Intensification of insulin substitution in adolescents and children with type I diabetes mellitus].
abstract: In order to approach the therapeutic goal of normoglycemia in diabetic children and adolescents, new forms of insulin substitution have been developed and subsequently tested as "intensified conventional insulin therapy" or "multiple daily insulin injections". Typical for this therapy are unmodified insulin injections before each main meal, administration of basal delayed insulin at night and if necessary also during the day, regular daily blood sugar analyses as an aid to decisions regarding therapy, and variation of the unmodified doses according to certain general or individual rules. The article reviews the principles of this therapy, indications for it and the method employed, as well as the authors' own results and those published in the literature. It concludes with a discussion of complications in therapy, of controversial aspects of practical management and of the long-term perspectives.
authors.affiliation: Abteilung Allgemeine Pädiatrie der Univ.-Kinderklinik Tübingen.
authors.forename: J
authors.initials: J
authors.lastname: Nothjunge
authors.forename: W
authors.initials: W
authors.lastname: Fesseler
authors.forename: U
authors.initials: U
authors.lastname: Fink
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D008297:Male
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin
vernacular_title: Intensivierung der Insulinsubstitution bei Jugendlichen und Kindern mit Typ-I-Diabetes mellitus.