Retinoids and vertebrate limb pattern formation.
It has long been suggested that pattern formation depends in part on signalling molecules known as 'morphogens', diffusible substances that determine cell fate in a concentration-dependent way. Retinoic acid, a small hydrophobic molecule that binds to nuclear receptors, is a candidate morphogen for specifying the anteroposterior pattern of vertebrate limbs.
Eichele
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D000818:Animals; D002642:Chick Embryo; D005121:Extremities / Q000254:growth & development*; D015870:Gene Expression; D009024:Morphogenesis; D015398:Signal Transduction; D014212:Tretinoin / Q000494:pharmacology*
D014212:Tretinoin