title: [The use of digoxin, lasix and finoptin in treating circulatory failure in hypertension].
abstract: As many as 118 middle-aged and elderly patients suffering from essential hypertension with different stages of circulatory failure (CF) were examined. In elderly patients suffering from CF, the activity of the renin-angiotensin-aldosterone system turned out lower while the adenylate cyclase system was activated earlier than in middle-aged patients. Introduction of verapamil into a complex of therapeutic measures promoted stabilization or reduction of aldosterone concentration in plasma, induced prolonged diuresis, and diminished acute losses of electrolytes. These circumstances formed the basis for combined use of digoxin, furosemide and verapamil in the treatment of elderly patients suffering from circulatory failure.
authors.forename: M A
authors.initials: MA
authors.lastname: Orynchak
mesh_terms: D000368:Aged; D000450:Aldosterone / Q000097:blood; D004077:Digoxin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009712:Nucleotides, Cyclic / Q000097:blood; D011188:Potassium / Q000097:blood; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood; D014700:Verapamil / Q000627:therapeutic use*
chemical_list: D009712:Nucleotides, Cyclic; D000450:Aldosterone; D004077:Digoxin; D005665:Furosemide; D012964:Sodium; D014700:Verapamil; D012083:Renin; D011188:Potassium
vernacular_title: Primenenie digoksina, laziksa i finoptina dlia lecheniia nedostatochnosti krovoobrashcheniia pri gipertonicheskoĭ bolezni.