title: Chromosomal location and evolutionary rate variation in enterobacterial genes.
abstract: The basal rate of DNA sequence evolution in enterobacteria, as seen in the extent of divergence between Escherichia coli and Salmonella typhimurium, varies greatly among genes, even when only "silent" sites are considered. The degree of divergence is clearly related to the level of gene expression, reflecting constraints on synonymous codon choice. However, where this constraint is weak, among genes not expressed at high levels, divergence is also related to the chromosomal location of the gene; it appears that genes furthest away from oriC, the origin of replication, have a mutation rate approximately two times that of genes near oriC.
authors.affiliation: Department of Genetics, Trinity College, Dublin, Ireland.
authors.forename: P M
authors.initials: PM
authors.lastname: Sharp
authors.forename: D C
authors.initials: DC
authors.lastname: Shields
authors.forename: K H
authors.initials: KH
authors.lastname: Wolfe
authors.forename: W H
authors.initials: WH
authors.lastname: Li
mesh_terms: D015982:Bias; D005075:Biological Evolution; D002876:Chromosomes, Bacterial; D003062:Codon / Q000235:genetics; D004260:DNA Repair; D004261:DNA Replication; D004269:DNA, Bacterial / Q000235:genetics; D004755:Enterobacteriaceae / Q000235:genetics* / Q000648:ultrastructure; D004926:Escherichia coli / Q000235:genetics / Q000648:ultrastructure; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D009154:Mutation; D012044:Regression Analysis; D012486:Salmonella typhimurium / Q000235:genetics / Q000648:ultrastructure
chemical_list: D003062:Codon; D004269:DNA, Bacterial