Lymphomatoid papulosis: ultrastructural, immunohistochemical and gene analytical studies.
Ultrastructural, immunohistochemical and gene analytical studies were carried out on a 39-year-old patient with lymphomatoid papulosis. Two different cell groups were demonstrated in the papulonodular eruptions: large atypical cells with multiple nuclei that were well stained with anti-Tac, but not with Leu 3a, and other cells that possessed prominent hyperchromatic nuclei and which stained well with Leu I and Leu 3a but not with anti-Tac. Gene analytical studies using EcoRI, BamHI and HindIII revealed no rearrangement, indicating a non-clonal T-cell proliferation unlike malignant T-cell lymphoma. These results suggest that the present case was benign.
Matsuyoshi
N
N
Department of Dermatology, Faculty of Medicine, Kyoto University, Japan.
Horiguchi
Y
Y
Tanaka
T
T
Takahashi
K
K
Dosaka
N
N
Fujita
M
M
Miyachi
Y
Y
Imamura
S
S
D000328:Adult; D000954:Antigens, Surface / Q000032:analysis; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D012867:Skin / Q000276:immunology* / Q000648:ultrastructure; D012871:Skin Diseases / Q000235:genetics / Q000276:immunology* / Q000473:pathology
D000954:Antigens, Surface