title: A randomized trial to develop criteria for administering erythrocyte transfusions to anemic preterm infants 1 to 3 months of age.
abstract: A randomized trial of erythrocyte transfusion vs no transfusion was performed in 16 preterm infants 1 to 3 months old with hematocrits of less than or equal to 0.29 L/L. To determine which (if any) such patients definitely benefit from transfusion, an analysis of outcome variables was performed. Factors that prospectively identified patients who would benefit from transfusions included a heart rate of greater than 152 beats per minute (P less than .01), apnea/bradycardia (heart rate less than 90/min) requiring intervention to increase the heart rate (P less than .01), and a blood lactate level above the reference range (P less than .02). Additional investigations were performed to determine the cause of the low hematocrits in the study patients. All had diminished, rather than accelerated, erythropoiesis. However, neither the anemia of chronic disorders nor iron deficiency anemia contributed to the diminished erythropoiesis. In all cases, serum erythropoietin levels were below the predicted range (P less than .001). Thus, at least some preterm infants aged 1 to 3 months with hematocrits less than or equal to 0.29 L/L definitely derive benefit from erythrocyte transfusion. The presence of tachycardia, apnea/bradycardia, or an elevated blood lactate may prospectively identify such patients.
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84132.
authors.forename: M P
authors.initials: MP
authors.lastname: Ross
authors.forename: R D
authors.initials: RD
authors.lastname: Christensen
authors.forename: G
authors.initials: G
authors.lastname: Rothstein
authors.forename: J M
authors.initials: JM
authors.lastname: Koenig
authors.forename: M A
authors.initials: MA
authors.lastname: Simmons
authors.forename: N A
authors.initials: NA
authors.lastname: Noble
authors.forename: R E
authors.initials: RE
authors.lastname: Kimura
mesh_terms: D000751:Anemia, Neonatal / Q000097:blood / Q000150:complications / Q000628:therapy*; D001049:Apnea / Q000209:etiology / Q000628:therapy; D001803:Blood Transfusion; D001919:Bradycardia / Q000209:etiology / Q000628:therapy; D017707:Erythrocyte Transfusion; D004920:Erythropoiesis; D006339:Heart Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood / Q000628:therapy*; D007773:Lactates / Q000097:blood; D011237:Predictive Value of Tests; D016032:Randomized Controlled Trials as Topic; D015430:Weight Gain
chemical_list: D007773:Lactates