[Antiviral activity of ribamidyl in experimental infections with California encephalitis group viruses].
A preparation of ribamydil, an analogue of natural nucleosides, synthesized at the Latvian SSR Institute of Organic Chemistry showed a sufficiently high activity against bunyaviruses of California encephalitis complex both in vitro and in vivo. Various modifications of the enzyme immunoassay may be used for control of the effectiveness of treatment with this drug. Some advantages of the subcutaneous route over the intramuscular one were found. Ribamydil may be useful for treatment of infections of California encephalitis complex.
Berezina
L K
LK
Bystrova
E A
EA
Shliankevich
A M
AM
Abramova
L N
LN
Gushchina
E A
EA
Korbukh
I A
IA
Nekrasova
E B
EB
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D000998:Antiviral Agents / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D002522:Chlorocebus aethiops; D002141:Encephalitis Virus, California / Q000187:drug effects / Q000276:immunology; D004671:Encephalitis, Arbovirus; D004670:Encephalitis, California / Q000188:drug therapy* / Q000276:immunology; D007124:Immunoenzyme Techniques; D051379:Mice; D011817:Rabbits; D012254:Ribavirin / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D012263:Ribonucleosides / Q000494:pharmacology*
D000956:Antigens, Viral; D000998:Antiviral Agents; D012263:Ribonucleosides; D012254:Ribavirin
Protivovirusnaia aktivnost' ribamidila pri éksperimental'nykh infektsiiakh virusami kompleksa kaliforniĭskogo éntsefalita.