[Clinico-pharmacologic study of a new sustained-release oral salbutamol preparation in patients with obstructive airway disease].
A new sustained release preparation of oral salbutamol (8 mg) was compared to salbutamol (8 mg) and placebo in 15 patients suffering from chronic obstructive airways disease in a randomized double-blind cross-over trial. Changes in airways resistance and amplitude of finger tremor as well as subjective assessment of side effects (tremors, unrest, palpitations) revealed a longer lasting effect following the sustained release preparation of salbutamol.
Bauer
K
K
I. Medizinischen Universitätsklinik, Wien.
Lorenz
P R
PR
Seibel
K
K
Neiss
A
A
Eandi
M
M
Kaik
G
G
D000328:Adult; D000420:Albuterol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012129:Respiratory Function Tests
D001786:Blood Glucose; D003692:Delayed-Action Preparations; D000420:Albuterol
Klinisch-pharmakologische Untersuchungen mit einem neuen retardierten oralen Salbutamol bei Patienten mit obstruktiver Atemwegserkrankung.