Effect of antemortem and postmortem factors on [3H]MK-801 binding in the human brain: transient elevation during early childhood.
The effect of a number of antemortem and postmortem factors on [3H]MK-801 binding was investigated under equilibrium conditions in the frontal cortex of human brains of 38 controls. Binding values transiently increased during the early postnatal period reaching a maximum at the age of about 2 years. After age 10 years [3H]MK-801 binding sites disappeared at 5.7% per decade. The storage time of brain tissue had a reducing effect on these binding sites. There was no effect of gender, brain weight or postmortem time interval and the binding sites were bilaterally symmetrically distributed in the frontal cortex.
Kornhuber
J
J
Department of Psychiatry, University of Würzburg, F.R.G.
Mack-Burkhardt
F
F
Konradi
C
C
Fritze
J
J
Riederer
P
P
D000367:Age Factors; D000927:Anticonvulsants / Q000378:metabolism*; D001665:Binding Sites; D003080:Cold Temperature; D003986:Dibenzocycloheptenes / Q000378:metabolism*; D016291:Dizocilpine Maleate; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D011180:Postmortem Changes; D011309:Preservation, Biological; D012737:Sex Factors; D013997:Time Factors
D000927:Anticonvulsants; D003986:Dibenzocycloheptenes; D016291:Dizocilpine Maleate