Altered cellular responses to chemical carcinogens in aged animals.
The well-known increase in cancer incidence during aging is examined with a view toward establishing a cellular basis for the changes that might contribute to age-dependent carcinogenesis. It is hypothesized that during aging some tissues may enter into an altered state of growth regulation resembling that of tumor promotion. Entry into this state could be an event that precipitates cancer development in cells that already have been initiated.
Zimmerman
J A
JA
Department of Biological Sciences, St. John's University, New York, NY.
Carter
T H
TH
D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology* / Q000633:toxicity; D009374:Neoplasms, Experimental / Q000139:chemically induced*
D002273:Carcinogens