title: Pathogenetic aspects of involutional osteoporosis.
abstract: The pathogenetic factors of postmenopausal and senile osteoporosis are reviewed. Both postmenopausal and senile osteoporosis occur as a result of a defective regulation of bone remodelling which leads to a negative uncoupling between bone resorption and bone formation. Systemic and local factors contribute to the development of the phenomenon. While studies of the systemic factors involved in age-related bone loss are well advanced, although still incomplete, the study of the local factors responsible at a tissue level for the negative skeletal balance has barely begun.
authors.affiliation: IV Patologia Medica, University of Rome La Sapienza, Italy.
authors.forename: G F
authors.initials: GF
authors.lastname: Mazzuoli
authors.forename: E
authors.initials: E
authors.lastname: D'Erasmo
authors.forename: S
authors.initials: S
authors.lastname: Minisola
authors.forename: S
authors.initials: S
authors.lastname: Tabolli
authors.forename: F
authors.initials: F
authors.lastname: Bigi
authors.forename: G
authors.initials: G
authors.lastname: Bianchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008593:Menopause / Q000502:physiology; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology* / Q000503:physiopathology