[Experimental study of a new biological preparation for treating E. coli infection and Proteus dysbacteriosis in young infants].
The action of a new biological preparation intended for the treatment of E. coli infection and Proteus dysbacteriosis in children has been studied in experiments on mice and suckling rabbits. The protective activity of anti-E. coli and anti-Proteus lactoglobulin has been found to exceed that of normal lactoglobulin 6- to 13-fold. When subjected to the action of proteolytic enzymes of the gastrointestinal tract, the preparation retains its preventive properties on the level of the native preparation, which confirms the possibility of the oral administration of the preparation in clinical practice without protecting it from the proteolytic action of the enzymes of the gastrointestinal tract.
Soboleva
S V
SV
Mineeva
L D
LD
Rabinovich
V D
VD
Fedorova
T A
TA
D000818:Animals; D000833:Animals, Suckling; D004353:Drug Evaluation, Preclinical; D004355:Drug Stability; D004926:Escherichia coli / Q000187:drug effects / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000382:microbiology / Q000628:therapy*; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D007782:Lactoglobulins / Q000187:drug effects / Q000627:therapeutic use*; D051379:Mice; D010447:Peptide Hydrolases / Q000494:pharmacology; D011512:Proteus Infections / Q000382:microbiology / Q000628:therapy*; D011513:Proteus mirabilis / Q000187:drug effects / Q000472:pathogenicity; D011817:Rabbits; D014774:Virulence / Q000187:drug effects
D007782:Lactoglobulins; D010447:Peptide Hydrolases
Eksperimental'noe izuchenie novogo biologicheskogo preparata dlia lecheniia koli-infektsii i proteĭnogo disbakterioza u deteĭ rannego vozrasta.