Drug-reinforced responding: rapid determination of dose-response functions.
Rhesus monkeys were conditioned to press on levers and receive intravenous infusions of cocaine or ketamine. Experimental conditions provided several different doses of drug during each of two daily 130 min sessions; as a result, a dose-response curve relating rate of responding to dose/injection for self-administered drug was obtained within each session. Relative rate-maintaining effects of nomifensine and cocaine in monkeys on baseline conditions of cocaine self-administration, and rate-maintaining effects of ketamine, phencyclidine and MK-801 in monkeys on baseline conditions of ketamine self-administration, compared favorably with relative rate-maintaining effects of these substances obtained in more traditional paradigms.
Winger
G
G
Department of Pharmacology, University of Michigan, Ann Arbor 48109.
Palmer
R K
RK
Woods
J H
JH
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001070:Appetitive Behavior / Q000187:drug effects*; D001143:Arousal / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D003986:Dibenzocycloheptenes / Q000494:pharmacology; D016291:Dizocilpine Maleate; D004305:Dose-Response Relationship, Drug; D005260:Female; D007275:Injections, Intravenous; D007649:Ketamine / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male; D009042:Motivation; D009627:Nomifensine / Q000494:pharmacology; D010622:Phencyclidine / Q000494:pharmacology; D012646:Self Administration
D000927:Anticonvulsants; D003986:Dibenzocycloheptenes; D009627:Nomifensine; D007649:Ketamine; D016291:Dizocilpine Maleate; D003042:Cocaine; D010622:Phencyclidine