Asymmetric synthesis of 2-substituted-3-aminocarbonyl propionic acid.
An asymmetric synthetic route to 2-substituted-3-aminocarbonyl propionic acid, which is the significant component of low-molecular-weight renin inhibitors, is described. The key step of this synthesis is diastereoselective alkylation by using chiral oxazolidinone and benzyl bromoacetate.
Nishi
T
T
Sakurai
M
M
Sato
S
S
Kataoka
M
M
Morisawa
Y
Y
D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D011422:Propionates / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D000092502:Renin Inhibitors
D011422:Propionates; D000092502:Renin Inhibitors