Analgesic nitrous oxide for alcohol withdrawal is better than placebo.
We present data distinguishing the placebo response from the action of analgesic nitrous oxide in alcohol withdrawal. We also discuss the difficulties of undertaking double-blind controlled studies when using analgesic nitrous oxide as an active agent. A novel method of overcoming these problems is presented. The role of the postulated hyperalgesic opioid system in the negative placebo response is mentioned.
Lichtigfeld
F J
FJ
South African Brain Research Institute, Johannesburg.
Gillman
M A
MA
D000328:Adult; D004311:Double-Blind Method; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide / Q000627:therapeutic use*; D010919:Placebos / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D010919:Placebos; D000431:Ethanol; D009609:Nitrous Oxide