title: Procoagulant effects of intraocular sodium hyaluronate (Healon) after phakic diabetic vitrectomy. A prospective, randomized study.
abstract: A procoagulant effect was reported previously after injection of 0.50 to 0.75 ml of sodium hyaluronate (Healon) into the vitreous cavity at the end of phakic diabetic vitrectomies. A multicenter, randomized, prospective trial was done to study this effect. In the treatment group the media was clear in 50% of eyes in the immediate postoperative period compared with only 8% in the control group. At 2 to 6 weeks, there was no statistically significant difference between the two groups. The authors conclude that such sodium hyaluronate injection provides clear media in a significant number of eyes in the immediate postoperative period, potentially allowing thorough postoperative evaluation and early retinal photocoagulation if needed.
authors.affiliation: Department of Ophthalmology, Louisiana State University, New Orleans.
authors.forename: A J
authors.initials: AJ
authors.lastname: Packer
authors.forename: B W
authors.initials: BW
authors.lastname: McCuen
authors.forename: W L
authors.initials: WL
authors.lastname: Hutton
authors.forename: R C
authors.initials: RC
authors.lastname: Ramsay
mesh_terms: D000328:Adult; D003029:Coagulants / Q000009:adverse effects / Q000627:therapeutic use*; D003930:Diabetic Retinopathy / Q000601:surgery*; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D011182:Postoperative Care; D011446:Prospective Studies; D011897:Random Allocation; D014821:Vitrectomy / Q000009:adverse effects; D014823:Vitreous Hemorrhage / Q000188:drug therapy / Q000209:etiology
chemical_list: D003029:Coagulants; D006820:Hyaluronic Acid