title: The use of a hand-held gamma detector improves the safety of isolated limb perfusion.
abstract: We used two hand-held gamma-detecting probes (GDP) (Neoprobe 1000 system) capable of detecting small gamma emissions to monitor leakage in patients undergoing hyperthermic isolated limb perfusion (HILP) who received 800 microCi Technetium 99m pentetate through the perfusate. The percentage of gamma-ray leakage was calculated by a simultaneous reading of two probes at 1-minute intervals (one over the precordial area and one over the thigh) and this was compared to results of simultaneous blood sampling from the perfusate and systemic circulation at 15-minute intervals for gamma well counting (GWC). The percentage of leakage recorded by the GDPs was essentially identical to that detected by the GWC (7.3% and 8.2%, respectively at the conclusion of the perfusion). The GDP gives an immediate and accurate indication of the percentage of leakage during HILP, making it a safer procedure.
authors.affiliation: Ohio State University College of Medicine, Division of Surgical Oncology, Columbus.
authors.forename: A
authors.initials: A
authors.lastname: Sardi
authors.forename: J P
authors.initials: JP
authors.lastname: Minton
authors.forename: C
authors.initials: C
authors.lastname: Mojzisik
authors.forename: C A
authors.initials: CA
authors.lastname: Nieroda
authors.forename: P J
authors.initials: PJ
authors.lastname: Ferrara
authors.forename: G H
authors.initials: GH
authors.lastname: Hinkle
authors.forename: M O
authors.initials: MO
authors.lastname: Thurston
authors.forename: E W
authors.initials: EW
authors.lastname: Martin
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D010478:Chemotherapy, Cancer, Regional Perfusion; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000000981:diagnostic imaging*; D005260:Female; D005534:Foot Diseases / Q000188:drug therapy*; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008545:Melanoma / Q000188:drug therapy*; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011874:Radiometry / Q000295:instrumentation*; D011877:Radionuclide Imaging; D012878:Skin Neoplasms / Q000188:drug therapy*; D013667:Technetium; D016284:Technetium Tc 99m Pentetate
chemical_list: D009942:Organometallic Compounds; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate