Neomycin prevents indomethacin-induced gastric peristalsis and mucosal injury in the rat.
Inhibition of prostaglandin synthesis together with vagally mediated peristaltic contractions are essential if mucosal injury is to occur in the stomach of indomethacin-treated rats. The neomycin group of antibiotics has been shown to interfere with acetylcholine release. Agents blocking peristalsis have been demonstrated to prevent mucosal injury. We postulated that neomycin might inhibit peristalsis and prevent lesion formation. The effect of oral neomycin and bacitracin on gastric wall tone and peristaltic response to indomethacin were assessed and related to the lesion score. Bacitracin had no effect on either response and severe injury occurred. Neomycin did not block the tonal response to indomethacin but abolished peristalsis and no injury occurred. Induction of peristalsis with insulin in neomycin-indomethacin treated rats restored mucosal injury. It is concluded that neuromuscular blockade by neomycin prevented mucosal lesions by preventing peristalsis and not by impairing the ability of indomethacin to inhibit prostaglandin synthesis.
Mersereau
W A
WA
Division of General Surgery, Montréal General Hospital, Qué., Canada.
Hinchey
E J
EJ
D000818:Animals; D001414:Bacitracin / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007213:Indomethacin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D009355:Neomycin / Q000494:pharmacology*; D010528:Peristalsis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D001786:Blood Glucose; D007328:Insulin; D001414:Bacitracin; D009355:Neomycin; D007213:Indomethacin