Adverse effects of amiodarone. Pathogenesis, incidence and management.
Amiodarone is an extremely effective antiarrhythmic agent for the treatment of both life-threatening ventricular arrhythmias and refractory supraventricular tachyarrhythmias. Subjective minor side effects are common with amiodarone but rarely require discontinuation of therapy and are often handled by dose reduction. Serious end-organ toxicity, including pulmonary fibrosis and drug-induced hepatitis, have been the most common indications for discontinuing amiodarone therapy in these patients.
Naccarelli
G V
GV
Division of Cardiology, University of Texas Medical School, Houston.
Rinkenberger
R L
RL
Dougherty
A H
AH
Fitzgerald
D M
DM
D000638:Amiodarone / Q000009:adverse effects* / Q000633:toxicity; D000818:Animals; D005260:Female; D006801:Humans; D011247:Pregnancy; D013723:Teratogens
D013723:Teratogens; D000638:Amiodarone