Side effects of the trypanocidal chemotherapeutics trypan blue and suramin.
Both the uptake of C3-opsonized and of nonopsonized bakers' yeast is inhibited by 1 mM trypan blue. This effect may be explained by inactivation of the C3bi-receptor. But trypan blue also inhibited the uptake of other non-opsonized particles lacking specially binding domains for this receptor. - Suramin has antiphagocytic properties at 1 mM concentration which were explained by its anticomplementary activity. However, the uptake of nonopsonized particles is also inhibited by suramin. The importance of these effects for therapeutic utilization is discussed.
Ehlers
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Department of Zoology, Ernst Moritz Arndt University, Greifswald, GDR.
D000818:Animals; D006168:Guinea Pigs; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D009895:Opsonin Proteins; D010587:Phagocytosis / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000276:immunology*; D013498:Suramin / Q000009:adverse effects*; D014343:Trypan Blue / Q000009:adverse effects*
D009895:Opsonin Proteins; D013498:Suramin; D014343:Trypan Blue