[Liver glycogen and glucose tolerance in rats with prenatal development under hypoglycemic conditions].
Insulin injections to pregnant rats (1 ME/100 g body weight) induced obvious hypoglycaemia of the mother and its foetus, an increase of glycogen in the liver of foetus. At the reproductive age and the beginning of ageing of the litter, hyperglycaemia and a decrease of liver glycogen were observed. At the beginning of puberty, the glycaemic curves had a diabetic character. The adequate supply of foetus with glucose through the mother blood seems to be an important factor, determining the normal development of neuroendocrine regulation mechanisms of the carbohydrate metabolism.
Drzhevetskaia
I A
IA
Gubareva
L I
LI
D000375:Aging / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005333:Fetus; D007003:Hypoglycemia / Q000139:chemically induced / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D008112:Liver Glycogen / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011916:Rats, Inbred F344
D001786:Blood Glucose; D007328:Insulin; D008112:Liver Glycogen
Glikogen pecheni i tolerantnost' k gliukoze u krys s prenatal'nym razvitiem v usloviiakh gipoglikemii.