[Novel non-tumorigenic cell variants showing potentially different susceptibility to v-src induced metastasis].
Two non-tumorigenic variant cells were isolated from UV-irradiated BALB/c 3T3 cells according to their morphological responsiveness to phorbol ester tumor promoters. They exhibited remarkably different metastatic behavior after intravenous injections of their v-src transformants into nude mice; phorbol ester-resistant variant TR 4 cells transformed by v-src were hyper-metastatic, whereas v-src transformants of phorbol ester sensitive variant TR 5 cells were not metastatic at all. No different metastatic responses were observed with v-k-ras induced transformants of the variants. These non-tumorigenic variant cells may pre-acquire the genetic alteration of certain src-specific specific and metastasis-associated factors. This system may be useful for genetic analysis of the induction of metastasis.
Enomoto
T
T
Dept. of Oncogene Research, Osaka University.
Ayaki
H
H
D000818:Animals; D002461:Cell Line, Transformed; D014644:Genetic Variation; D051379:Mice; D008807:Mice, Inbred BALB C; D009362:Neoplasm Metastasis / Q000235:genetics* / Q000473:pathology; D009368:Neoplasm Transplantation; D009857:Oncogenes; D013755:Tetradecanoylphorbol Acetate
D013755:Tetradecanoylphorbol Acetate