title: Indomethacin reduces the risks of severe intraventricular hemorrhage.
abstract: A prospective, random selection, double-blind clinical trial was carried out to determine the efficacy of indomethacin in preventing periventricular-intraventricular hemorrhage (PV-IVH). Babies who were born in our institution, had birth weights less than or equal to 1500 gm, and had no PV-IVH or grade 1 PV-IVH were given either placebo (n = 70) or indomethacin (n = 71), 0.2 mg/kg intravenously at 6 hours of age and 0.1 mg/kg at 18 and 30 hours. Two major outcomes were determined: the development of grades 2 to 4 PV-IVH and the development of severe PV-IVH (i.e., hemorrhages with blood filling greater than 50% of the ventricles and in some cases with associated parenchymal echodensities). Grades 2 to 4 PV-IVH occurred in 16 (23%) of the indomethacin group and 27 (39%) of the placebo group (p less than 0.03). The incidence of severe PV-IVH was 3% in the indomethacin-treated babies and 14% in the control group (p less than 0.02). The influence of other perinatal factors on the incidence of grades 2 to 4 or severe PV-IVH was determined by stepwise logistic regression. Placebo use, early grade 1 PV-IVH, lower birth weight, and higher fraction of inspired oxygen at 6 hours of life were associated with higher estimated odds of the development of grades 2 to 4 PV-IVH. Placebo use, male gender, lower 5-minute Apgar score, and a large base deficit were predictive of severe PV-IVH. Estimated odds ratios of severe PV-IVH with placebo use and male gender were 11.25:1 and 9:1, respectively. Thus indomethacin prophylaxis reduced the relative risk of grades 2 to 4 PV-IVH and severe PV-IVH, but other perinatal variables contributed significantly to the overall risk of PV-IVH.
authors.affiliation: Department of Pediatrics, University of Tennessee, Memphis.
authors.forename: H S
authors.initials: HS
authors.lastname: Bada
authors.forename: R S
authors.initials: RS
authors.lastname: Green
authors.forename: M
authors.initials: M
authors.lastname: Pourcyrous
authors.forename: C W
authors.initials: CW
authors.lastname: Leffler
authors.forename: S B
authors.initials: SB
authors.lastname: Korones
authors.forename: H L
authors.initials: HL
authors.lastname: Magill
authors.forename: K
authors.initials: K
authors.lastname: Arheart
authors.forename: C W
authors.initials: CW
authors.lastname: Fitch
authors.forename: G D
authors.initials: GD
authors.lastname: Anderson
authors.forename: G
authors.initials: G
authors.lastname: Somes
mesh_terms: D001034:Apgar Score; D001724:Birth Weight; D002543:Cerebral Hemorrhage / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D011446:Prospective Studies; D011897:Random Allocation; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D007213:Indomethacin