title: The great GATC: DNA methylation in E. coli.
abstract: In Escherichia coli the methylation of the adenine in the sequence 5'-GATC-3' is catalysed by the dam gene product, a DNA adenine methylase. We review the proposed roles for this methylation, and the sequence it modifies, in mismatch repair, DNA-protein interaction, gene expression, the initiation of chromosome replication, chromosome segregation, chromosome structure and the occurrence of mutational hotspots.
authors.forename: F
authors.initials: F
authors.lastname: Barras
authors.forename: M G
authors.initials: MG
authors.lastname: Marinus
mesh_terms: D001483:Base Sequence; D002876:Chromosomes, Bacterial; D015254:DNA Modification Methylases / Q000378:metabolism*; D004261:DNA Replication; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics*; D005786:Gene Expression Regulation; D008745:Methylation
chemical_list: D004269:DNA, Bacterial; D015254:DNA Modification Methylases