title: Aging and drug-induced optic nerve side effects.
abstract: In this review the authors attempt to explain how aging can determine optic nerve neuropathy and modify the pharmacodynamics and pharmacokinetics of a drug. The major causes of increased drug toxicity in the elderly are discussed. The most frequently used drugs that can cause optic nerve side effects are reported. The authors stress problems related to drug administration in the elderly and push towards the study of this aspect of geriatric ophthalmology.
authors.affiliation: Padua University Eye Clinic, Italy.
authors.forename: M T
authors.initials: MT
authors.lastname: Dorigo
authors.forename: R
authors.initials: R
authors.lastname: Altafini
mesh_terms: D000375:Aging; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000928:Antidepressive Agents / Q000009:adverse effects; D001682:Biological Availability; D001812:Blood-Brain Barrier; D004232:Diuretics / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D009901:Optic Nerve Diseases / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D000928:Antidepressive Agents; D004232:Diuretics