[Analysis of PO2 in brain tumor and effectiveness of PFC (perfluorochemicals) to increase intratumoral PO2, blood flow and its clinical use].
The presence of hypoxic Zone in clinical brain tumor is verified. The value of intratumoral PO2 is about 16 mmHg under the condition with physiological PaO2. Perfluorocarbon, which can transport rich O2, was used to increase intratumoral PO2. Intratumoral PO2 increased to about 36 mmHg by using Perfluorocarbon with inhalation of O2. I conducted new Protocol, namely, irradiation method should be selected altered dose fractionation when hypoxic cell of the tumor change to normoxic cell. Perfluorocarbon was administered on the day when irradiation dose is high. Clinical result showed much better than previous our result, especially in the group of glioblastoma, the mean survival duration prolonged 8 months to 2 years.
Kayama
T
T
Dept. of Neurosurgery, Sendai National Hospital.
Sakurai
Y
Y
Yoshimoto
T
T
D001932:Brain Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000532:radiotherapy*; D005466:Fluorocarbons / Q000627:therapeutic use*; D005910:Glioma / Q000098:blood supply / Q000378:metabolism / Q000532:radiotherapy; D006801:Humans; D010100:Oxygen / Q000378:metabolism*; D010102:Oxygen Inhalation Therapy; D010313:Partial Pressure; D011838:Radiation-Sensitizing Agents; D011879:Radiotherapy Dosage; D012039:Regional Blood Flow / Q000187:drug effects
D005466:Fluorocarbons; D011838:Radiation-Sensitizing Agents; D010100:Oxygen