Euglycemic hyperinsulinemia increases glucose 1,6-bisphosphate in human skeletal muscle.
1. The effects of physiologic concentrations of insulin on the contents of glucose 1,6-bisphosphate (glucose 1,6-P2) and regulators of glucose 1,6-P2 synthase in intact human skeletal muscle have been investigated. 2. Insulin increased glucose 1,6-P2 from a basal value of 70 +/- 6 to 135 +/- 12 mumol/kg dry wt (P less than 0.001). 3. Activation of synthase could not be associated with changes in its inhibitors (fructose 1,6-P2, Pi, citrate) or its substrate glucose 6-P.
Katz
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A
Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive and Kidney Diseases, Phoenix, AZ 85016.
Nyomba
B L
BL
Bogardus
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C
D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives*; D005958:Glucosephosphates / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000494:pharmacology; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism
D001786:Blood Glucose; D005958:Glucosephosphates; D007328:Insulin; D010710:Phosphates; D019298:Glucose-6-Phosphate; C016473:glucose-1,6-bisphosphate