Immunohistochemical determination of tumour growth fraction in human ovarian carcinoma.
The proportion of proliferating tumour cells in a tumour ('growth fraction') was estimated in 30 patients with primary ovarian carcinoma, using monoclonal antibody Ki-67 which reacts with a nuclear antigen present only in proliferating cells. A positive correlation between the 'growth fraction' and both the clinical stage and histological grade of the tumours was observed. A high 'growth fraction' was observed in advanced, metastatic and poorly differentiated tumours and a low 'growth fraction' with early stage, well-differentiated tumours. This information which has not been available previously to clinicians may be of practical value for determining the prognosis, and influencing treatment recommendation.
Wong
W S
WS
Ludwig Institute for Cancer Research (Sydney Branch), Department of Cancer Medicine, University of Sydney, NSW, Australia.
Tattersall
M H
MH
D000911:Antibodies, Monoclonal; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D002455:Cell Division; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D010053:Ovary / Q000473:pathology
D000911:Antibodies, Monoclonal