title: [Improving venous tone and capillary sealing. Effect of a combination of Ruscus extract and hesperidine methyl chalcone in healthy probands in heat stress].
abstract: The drug combination of Ruscus-extract and hesperidine methyl chalcone (HMC) involves two basic mechanisms in the treatment of venous diseases: increase in venous tonicity and edema protection. This was shown in a double-blind study on 20 healthy volunteers by comparing the effectiveness of the individual substances, the combination and a placebo on the venous hemodynamics and the volume of the foot. Ruscus-extract augments the tonicity of the venous wall. This is expressed by a decrease in venous capacity (p less than 0.01), a reduction in the blood pool in the lower leg under orthostatic conditions, and a decrease in tissue volume of the foot and ankle (p less than 0.01). HMC lowers the capillary filtration rate (p less than 0.01) but augmented the blood pool. The increase in blood volume can be explained by dehydration of the tissue of the lower leg lowering the pressure of tissue on the venous system and increasing the blood pool in the limb. After administration of the combination, the blood volume was between the Ruscus and HMC volumes, while the effects on filtration rate, venous capacity and tissue volume corresponded to the changes seen after administration of HMC and Ruscus extract alone.
authors.forename: G
authors.initials: G
authors.lastname: Rudofsky
mesh_terms: D000328:Adult; D002199:Capillary Permeability / Q000187:drug effects*; D002599:Chalcone / Q000031:analogs & derivatives / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D005528:Foot / Q000098:blood supply*; D006439:Hemodynamics / Q000187:drug effects; D006569:Hesperidin / Q000031:analogs & derivatives / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D011427:Propiophenones / Q000494:pharmacology*; D011897:Random Allocation; D014680:Veins / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D005419:Flavonoids; D010936:Plant Extracts; D011427:Propiophenones; C035564:phlebodril; D002599:Chalcone; D006569:Hesperidin
vernacular_title: Venentonisierung und Kapillarabdichtung. Die Wirkung der Kombination aus Ruscus-Extrakt und Trimethylhesperidinchalkon bei gesunden Probanden unter Wärmebelastung.