title: [Fetal systolic time intervals in threatened premature labor and their relation to therapeutic efforts].
abstract: In a total of 113 single pregnancies we determined foetal systolic time intervals (pre-ejection period, left ventricular ejection time, a quotient of both) in order to investigate the impact of threatened premature labour and the different therapeutic regimen (betamimetics, maternal O2-inhalation, maternal transcutaneous dorsal nerve stimulation) on the myocardial performance capacity. Prolonged systolic time intervals (significant for pre-ejection period) in threatened premature labour (compared with control) supplement the concept of a chronic respiratory impairment of the foe-to-materno-placental relationships. Therapeutic prolongation of the pregnancy by betamimetics led to further impairment of the myocardial contractility while additional oxygen inhalation brought about a positive effect. As indicated by "no changes" after transcutaneous dorsal nerve stimulation, the decisive effect apparently seems not to be in the improvement of the uteroplacental perfusion but more on the direct influence of the raised O2-provision on the foetal myocardium. Non-demonstrable obvious relations to the cardiotocographic findings, such as to the postnatal evaluation criteria, speak against a serious threat to the foetus as the advantages of a reasonable prolongation of the gestational period by betamimetics preponderate. More than that the foetal myocardial impairments are to be favourably influenced by additional O2-therapy.
authors.affiliation: Klinik für Frauenkrankheiten und Geburtshilfe, Karl-Marx-Universität Leipzig.
authors.forename: K E
authors.initials: KE
authors.lastname: Ruckhäberle
authors.forename: C
authors.initials: C
authors.lastname: Vogtmann
authors.forename: J
authors.initials: J
authors.lastname: Forberg
authors.forename: B
authors.initials: B
authors.lastname: Viehweg
authors.forename: S
authors.initials: S
authors.lastname: Chaikha
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D015148:Cardiotocography; D003131:Combined Modality Therapy; D004599:Electric Stimulation Therapy; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage*; D005865:Gestational Age; D006340:Heart Rate, Fetal / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D009200:Myocardial Contraction / Q000187:drug effects*; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D010102:Oxygen Inhalation Therapy; D011247:Pregnancy; D013599:Systole / Q000187:drug effects*; D004561:Transcutaneous Electric Nerve Stimulation; D014463:Ultrasonography
chemical_list: D005280:Fenoterol
vernacular_title: Fetale systolische Zeitintervalle bei drohender Frühgeburt und deren Abhängigkeit von therapeutischen Bemühungen.