[Structure and properties of lipoteichoic acid of group A Streptococcus type M 29].
Lipoteichoic acid (LTA) of group A streptococci, type M 29 was studied. Chemical and 13C NMR spectroscopic analysis showed that the polymer contained poly(glycerophosphate) chain consisting of 12-14 glycerophosphate elements united by the 1----3 type phosphodiether bond and diglucosylglyceride. Oleic, stearic, palmitic and palmitoleic fatty acids predominated in the polymer composition. The content of the fatty acids amounted approximately to 2 per cent of LTA dry weight. The poly(glycerophosphate) chain contained 6-7 ether linked alanyl moieties. The results of the LTA biological study were analyzed in comparison to the data on a previous study of antitumor and cardiotoxic properties of teichoic acid from Streptomyces levoris K-3053 which is structurally close to the LTA hydrophilic moiety. It was assumed that the molecule negative charge had an effect on the cardiotoxic and antitumor activity.
Vylegzhanina
E S
ES
Dmitrieva
N F
NF
Naumova
I B
IB
Chekanova
Iu I
IuI
Epishin
Iu N
IuN
Oksman
T M
TM
D002462:Cell Membrane / Q000378:metabolism; D002854:Chromatography, Paper; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism; D005994:Glycerophosphates / Q000032:analysis / Q000378:metabolism; D008070:Lipopolysaccharides / Q000032:analysis* / Q000302:isolation & purification / Q000378:metabolism; D008968:Molecular Conformation; D013297:Streptococcus pyogenes / Q000378:metabolism*; D013682:Teichoic Acids / Q000302:isolation & purification / Q000378:metabolism
D005227:Fatty Acids; D005994:Glycerophosphates; D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid
Stroenie i svoĭstva lipoteĭkhoevoĭ kisloty streptokokka gruppy A tipa M 29.