Drug-induced acute pancreatitis. A critical review.
Acute pancreatitis has a high morbidity and significant mortality. Among its many causes ethanol is pre-eminent, but many other drugs have also been incriminated. This article begins with a definition of the mechanisms, pathogenesis and clinical features of acute pancreatitis; it then critically reviews the evidence for drugs, excluding ethanol, as being causative. The drugs which have been implicated are considered under 3 headings: definite associations, probable associations and unlikely associations. A brief outline of possible treatment, strategies and prognosis associated with acute pancreatitis concludes the article.
Banerjee
A K
AK
Department of Surgery, M.R.C. Clinical Research, Centre London, England.
Patel
K J
KJ
Grainger
S L
SL
D000208:Acute Disease; D000818:Animals; D006801:Humans; D010195:Pancreatitis / Q000139:chemically induced* / Q000503:physiopathology