title: Substances with antineoplastic activity. XCVI. Some pharmacological properties and therapeutic synergism of 6-purinyl-N-(2-chloroethyl)thiocarbamate with cytosine arabinoside.
abstract: The cancerostatic effect of 6-purinyl-N-(2-chloroethyl)thiocarbamate (Cloturin VUFB, VUFB-15686) was studied in detail in mice and rats bearing transplantable tumors. The cytotoxic activities were measured by determining the incorporation rate of 5-iodo-2'-deoxy[6-3H]uridine and uniformly labeled [U-14C]amino acid mixture into trichloroacetic acid-insoluble fraction of Yoshida ascites reticulosarcoma cells during a short-term incubation with the drug. From the results obtained it follows that the new substance is therapeutically more effective in comparison with 6-mercaptopurine (NSC-755). A therapeutic synergism of Cloturin with cytosine arabinoside (NSC-63978) was observed.
authors.affiliation: Research Institute for Pharmacy and Biochemistry, Prague, Czechoslovakia.
authors.forename: M
authors.initials: M
authors.lastname: Mĕlka
authors.forename: J
authors.initials: J
authors.lastname: Krepelka
authors.forename: M
authors.initials: M
authors.lastname: Miko
authors.forename: S
authors.initials: S
authors.lastname: Pokorná
authors.forename: I
authors.initials: I
authors.lastname: Kejhová
authors.forename: R
authors.initials: R
authors.lastname: Reichlová
authors.forename: M
authors.initials: M
authors.lastname: Beitová
authors.forename: J
authors.initials: J
authors.lastname: Grimová
authors.forename: A
authors.initials: A
authors.lastname: Kargerová
authors.forename: J
authors.initials: J
authors.lastname: Sedivá
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage / Q000627:therapeutic use*; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects; D005260:Female; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000378:metabolism; D008546:Melanoma, Experimental / Q000188:drug therapy; D015122:Mercaptopurine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL; D009150:Mustard Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D012334:RNA, Neoplasm / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D009150:Mustard Compounds; D012334:RNA, Neoplasm; D003561:Cytarabine; C057648:Cloturin; D015122:Mercaptopurine