title: Inflammation and immunity in dermatophytosis.
abstract: Infections by dermatophytes (dermatophytosis) naturally stimulate the immune system as in those by other microorganisms to induce various immunological phenomena. However, differing from other infections, the infecting organisms cannot become a direct target of antibody response or phagocytosis because they reside only in the barrier membrane of the body surface, i.e. in the stratum corneum. Thus, the immunity against dermatophytes is relative as compared with the absolute one noted in other infections such as measles and mumps. In dermatophytosis, a unique behavior of the epidermis as noted in contact dermatitis plays an important role in the defense against infection. Dermatitic changes induced by fungal products, particularly those due to contact sensitivity to a fungal antigen, trichophytin, enhance epidermopoiesis, which leads to increased turnover of the epidermis with their resultant elimination from the skin surface. Furthermore, the dermatophytes in the stratum corneum provoke transepidermal leukocyte chemotaxis by generating chemotactic C5a anaphylatoxin in exudating serum via alternative complement pathway activation in addition to a release of low molecular weight chemotactic factors. Such neutrophilic migration with the formation of subcorneal pustules also enhances epidermal proliferation as in psoriasis.
authors.affiliation: Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tagami
authors.forename: K
authors.initials: K
authors.lastname: Kudoh
authors.forename: H
authors.initials: H
authors.lastname: Takematsu
mesh_terms: D000818:Animals; D002455:Cell Division; D002634:Chemotaxis, Leukocyte; D002908:Chronic Disease; D003877:Dermatitis, Contact / Q000276:immunology; D003881:Dermatomycoses / Q000276:immunology*; D004195:Disease Models, Animal; D004817:Epidermis / Q000276:immunology; D006168:Guinea Pigs; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007108:Immune Tolerance; D007249:Inflammation / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D010328:Patch Tests / Q000379:methods; D011565:Psoriasis / Q000503:physiopathology; D013997:Time Factors; D014248:Trichophytin / Q000276:immunology
chemical_list: D014248:Trichophytin