[Studies on glucose metabolism and pancreatic endocrine function after simultaneous major resection of the liver and pancreas].
Simultaneous major resection of the liver and pancreas has been recently advocated for advanced biliary carcinomas, but the subsequent changes in glucose metabolism and pancreatic endocrine function have not been investigated. In this study, changes in glucose metabolism following simultaneous major hepatic and pancreatic resection were evaluated in dogs, especially changes in pancreatic endocrine function and islet morphology. While adequate IRI levels were maintained in the peripheral blood, the incidence of diabetes was lower in dogs given simultaneous major hepatic and pancreatic resection than in those given pancreatectomy alone. Portal vein IRI levels during arginine loading were significantly higher in the former group. Early after surgery, the volume density of pancreatic islets was increased in both groups, but significantly higher in dogs that did not develop diabetes after simultaneous resection than in dogs given pancreatectomy alone, and the frequency of large pancreatic islets in the former animals was higher than the latter. The incidence of diabetes was lower in dogs after simultaneous resection than after pancreatectomy alone. This seemed to be due to promotion of pancreatic islet regeneration caused by combined hepatic resection, which was demonstrated by a sustained level of IRI secreted by islets and marked islet hypertrophy.
Sanda
M
M
First Department of Surgery, School of Medicine, Mie University, Tsu, Japan.
D000818:Animals; D001120:Arginine; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000503:physiopathology; D004285:Dogs; D005260:Female; D005934:Glucagon / Q000097:blood / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006498:Hepatectomy / Q000379:methods; D006984:Hypertrophy; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism* / Q000473:pathology / Q000502:physiology; D008099:Liver / Q000378:metabolism; D008297:Male; D010180:Pancreatectomy / Q000379:methods; D012038:Regeneration
D007328:Insulin; D005934:Glucagon; D001120:Arginine; D005947:Glucose