Functional evolutionary divergence of proteolytic enzymes and their inhibitors.
The amino acid residues of protease inhibitors that interact directly with proteases are hypervariable, suggesting recent positive evolutionary selection for functional differences between them. A similar hypervariability is apparent in some proteases, which may be co-evolving with the inhibitors.
Creighton
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Darby
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D000818:Animals; D001665:Binding Sites; D005075:Biological Evolution; D005796:Genes; D014644:Genetic Variation; D006801:Humans; D010447:Peptide Hydrolases / Q000235:genetics* / Q000378:metabolism; D011480:Protease Inhibitors / Q000378:metabolism; D011487:Protein Conformation; D012641:Selection, Genetic
D011480:Protease Inhibitors; D010447:Peptide Hydrolases