title: Otrivine-antistin-pupil, corneal and conjunctival responses to topical administration.
abstract: The ocular effects of Otrivine-Antistin eyedrops have been measured in a placebo controlled single-blind study in sixteen healthy volunteers. The drops produced mild sympathomimetic responses in the eye but had no effect on corneal sensitivity or on intraocular pressure. The evidence indicates that use of Otrivine-Antistin imposes no risk to the subject.
authors.affiliation: Division of Pharmacological Sciences and Toxicology, United Medical School, St. Thomas's Campus, London.
authors.forename: D R
authors.initials: DR
authors.lastname: Trew
authors.forename: L A
authors.initials: LA
authors.lastname: Wright
authors.forename: S E
authors.initials: SE
authors.lastname: Smith
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000704:Analysis of Variance; D000865:Antazoline / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D016009:Chi-Square Distribution; D002986:Clinical Trials as Topic; D003228:Conjunctiva / Q000098:blood supply / Q000187:drug effects*; D003315:Cornea / Q000187:drug effects*; D004338:Drug Combinations / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011680:Pupil / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D007093:Imidazoles; D009883:Ophthalmic Solutions; C018116:antazoline, xylometazoline drug combination; D000865:Antazoline