Postoperative active-specific immunotherapy of lymph node micrometastasis in a guinea pig tumor model.
Strain 2 guinea pigs bearing the transplanted intradermally growing line 10 tumor underwent surgical tumor excision at a time when the tumor had already metastasized to the first draining lymph node. Postoperative active-specific immunotherapy (ASI) consisted of two vaccinations with either Newcastle disease virus (NDV) modified or BCG-admixed line 10 tumor cells. 32% of the animals were cured of residual lymphatic micrometastasis by ASI with NDV-modified tumor cells while ASI with BCG was successful in 45%. No synergistic effect was observed when both ASI procedures were combined. Vaccine preparations with mitomycin C inactivated tumor cells proved to be less (NDV) or noneffective (BCG) compared to those with irradiated tumor cells.
Bier
H
H
Department of Otorhinolaryngology, Klinikum Mannheim, FRG.
Armonat
G
G
Bier
J
J
Schirrmacher
V
V
Ganzer
U
U
D000818:Animals; D002460:Cell Line / Q000276:immunology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D007110:Immunity, Active; D007167:Immunotherapy / Q000379:methods*; D008114:Liver Neoplasms, Experimental / Q000276:immunology / Q000601:surgery / Q000628:therapy*; D008207:Lymphatic Metastasis; D009163:Mycobacterium bovis / Q000276:immunology; D009522:Newcastle disease virus / Q000276:immunology; D011184:Postoperative Period; D014407:Tumor Cells, Cultured / Q000276:immunology