Follow-up of infants with obstructive uropathy detected in utero and treated surgically postnatally.
Thirty-four infants with obstructive uropathy detected by prenatal ultrasonography at 34 +/- 0.56 weeks (SE) had surgery during the first 2 years of life. The growth and renal function of the 25 children after being followed for over 1 year are described. Twelve children had unilateral disease, and 13 had bilateral disease. All 12 children with unilateral disease grew at or above the fifth percentile and had normal renal function (glomerular filtration rate, 101 +/- 7 mL/min/1.73 m2). Thirteen children with bilateral disease were followed for 26.1 +/- 3.4 months. Growth was good: 10 of the 13 grew at or above the fifth percentile. The serum creatinine was 0.7 +/- 0.2 mg/dL, and the glomerular filtration rate was 91 +/- 10 mL/min/1.73 m2. One child required chronic dialysis. The prenatal diagnosis of urinary tract anomalies followed by early intervention may improve the long-term outcome of children with obstructive uropathy.
Reznik
V M
VM
Division of Pediatric Nephrology, University of California, San Diego, School of Medicine.
Murphy
J L
JL
Mendoza
S A
SA
Griswold
W R
WR
Packer
M G
MG
Kaplan
G W
GW
D002675:Child, Preschool; D003251:Constriction, Pathologic; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000175:diagnosis* / Q000601:surgery; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014463:Ultrasonography; D014517:Ureteral Obstruction / Q000175:diagnosis* / Q000601:surgery