title: Kinetic analysis of excitation-contraction coupling.
abstract: Recent studies of isolated muscle membrane have enabled induction and monitoring of rapid Ca2+ release from sarcoplasmic reticulum (SR)5 in vitro by a variety of methods. On the other hand, various proteins that may be directly or indirectly involved in the Ca2+ release mechanism have begun to be unveiled. In this mini-review, we attempt to deduce the molecular mechanism by which Ca2+ release is induced, regulated, and performed, by combining the updated information of the Ca2+ release kinetics with the accumulated knowledge about the key molecular components.
authors.affiliation: Department of Muscle Research, Boston Biomedical Research Institute, Massachusetts 02114.
authors.forename: N
authors.initials: N
authors.lastname: Ikemoto
authors.forename: M
authors.initials: M
authors.lastname: Ronjat
authors.forename: L G
authors.initials: LG
authors.lastname: Mészáros
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D007700:Kinetics; D009119:Muscle Contraction; D009132:Muscles / Q000502:physiology*; D015388:Organelles / Q000502:physiology; D012519:Sarcoplasmic Reticulum / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D002118:Calcium