Effects of endothelin on renal function and renin secretion in anesthetized rats.
The infusion of endothelin into the renal artery of anesthetized rats at 1 ng/kg per min, a dose with no influence on renal function, had no effect on the basal levels of plasma renin activity (PRA) and renin secretory rate (RSR), but significantly inhibited the isoproterenol-induced increases in PRA and RSR. Endothelin, 2 ng/kg per min, elicited significant decreases in renal hemodynamics and in urine formation but the mean arterial pressure was not affected. The possibility that endothelin may participate in controlling renal function and renin secretion in vivo warrants further attention.
Matsumura
Y
Y
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Japan.
Hisaki
K
K
Ohyama
T
T
Hayashi
K
K
Morimoto
S
S
D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D016232:Endothelins; D005919:Glomerular Filtration Rate; D007444:Inulin; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000187:drug effects; D012083:Renin / Q000097:blood*; D013997:Time Factors; D014563:Urodynamics / Q000187:drug effects
D016232:Endothelins; D010455:Peptides; D007444:Inulin; D012083:Renin