Effect of norharman on the mutagenicity of toluidine metabolites.
Among the different metabolites of o-toluidine only the nitroso and hydroxylamino derivatives were found to be very potent frameshift mutagens in the presence of the co-mutagen norharman and S9. In the absence of norharman and S9 they are only base pair mutagens. Norharman failed to evoke the mutagenicity of the non-carcinogenic m- and p-toluidine and their respective nitroso and hydroxylamino metabolites. This report highlights that norharman plays a role in the appearance of mutagenicity of certain carcinogenic amines and metabolites.
Gupta
R L
RL
Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Kaur
I P
IP
Gupta
A K
AK
Pathak
D P
DP
Juneja
T R
TR
D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D002243:Carbolines; D004347:Drug Interactions; D006247:Harmine / Q000031:analogs & derivatives / Q000633:toxicity*; D007536:Isomerism; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D014052:Toluidines / Q000378:metabolism / Q000633:toxicity*
D000470:Alkaloids; D002243:Carbolines; D009153:Mutagens; D014052:Toluidines; D006247:Harmine; C010262:norharman