title: Feline muscular dystrophy with dystrophin deficiency.
abstract: This is the first description of a dystrophin-deficient muscular dystrophy in domestic cats. The disorder appears to be of X-linked inheritance because it affected both males of a litter of four kittens. Immunoblotting and immunofluorescent detection of dystrophin showed dystrophin present in control cat muscle but no detectable dystrophin in either affected cat. The feline muscular dystrophy was progressive and histopathologically resembled human Duchenne/Becker muscular dystrophy except for the lack of fat infiltration and the presence of prominent hypertrophy of both muscle fibers and muscles groups in the feline disorder.
authors.affiliation: Department of Pathology, MSPCA/Angell Memorial Animal Hospital, Boston 02130.
authors.forename: J L
authors.initials: JL
authors.lastname: Carpenter
authors.forename: E P
authors.initials: EP
authors.lastname: Hoffman
authors.forename: F C
authors.initials: FC
authors.lastname: Romanul
authors.forename: L M
authors.initials: LM
authors.lastname: Kunkel
authors.forename: R K
authors.initials: RK
authors.lastname: Rosales
authors.forename: N S
authors.initials: NS
authors.lastname: Ma
authors.forename: J J
authors.initials: JJ
authors.lastname: Dasbach
authors.forename: J F
authors.initials: JF
authors.lastname: Rae
authors.forename: F M
authors.initials: FM
authors.lastname: Moore
authors.forename: M B
authors.initials: MB
authors.lastname: McAfee
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000235:genetics*; D002415:Cats; D016189:Dystrophin; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D015151:Immunoblotting; D008297:Male; D009124:Muscle Proteins / Q000235:genetics; D009132:Muscles / Q000032:analysis / Q000473:pathology; D009137:Muscular Dystrophy, Animal / Q000235:genetics* / Q000473:pathology; D014960:X Chromosome
chemical_list: D016189:Dystrophin; D009124:Muscle Proteins