title: [Long-term therapy with nitrates. How can continuous effectiveness be achieved?].
abstract: Due to rapidly occurring tolerance, "continuous" administration of nitrates can no longer be considered justified. The development of tolerance can be avoided and, thus, the antiischemic effect maintained during long-term treatment only by providing a nitrate-free interval. Dosing regimens with documented effectiveness in long-term controlled studies are available for both isosorbide dinitrate and isosorbide 5-mononitrate as well as for transdermal nitroglycerin systems.
authors.forename: W
authors.initials: W
authors.lastname: Rudolph
authors.forename: J
authors.initials: J
authors.lastname: Dirschinger
authors.forename: G
authors.initials: G
authors.lastname: Reiniger
authors.forename: A
authors.initials: A
authors.lastname: Beyerle
mesh_terms: D000279:Administration, Cutaneous; D000787:Angina Pectoris / Q000188:drug therapy*; D003327:Coronary Disease / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives; D009566:Nitrates / Q000008:administration & dosage*
chemical_list: D003692:Delayed-Action Preparations; D009566:Nitrates; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate
vernacular_title: Langzeittherapie mit Nitraten. Wie ist eine anhaltende Effektivität zu gewährleisten?