title: Use of a trypsin, Peru balsam, and castor oil spray on the oral mucosa: case report and review of the literature.
abstract: Granulex is an aerosolized spray (Dow B. Hickman Pharmaceuticals, Sugar Land, TX 77487) that contains trypsin, Peru balsam, and castor oil. It has been available for many years as a topical spray for the treatment of decubitus ulcers. We used Granulex to promote tissue healing of a necrotic ulcer of the oral mucosa in a patient with advanced oropharyngeal squamous cell carcinoma.
authors.affiliation: Department of Pharmacy Practice, College of Pharmacy, University of South Carolina, Columbia 29208.
authors.forename: T A
authors.initials: TA
authors.lastname: Noble
authors.forename: D S
authors.initials: DS
authors.lastname: Carr
authors.forename: M F
authors.initials: MF
authors.lastname: Gonzalez
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001453:Balsams / Q000008:administration & dosage / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D002368:Castor Oil / Q000008:administration & dosage / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D004338:Drug Combinations / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage; D009061:Mouth Mucosa; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D009910:Oral Hygiene; D014357:Trypsin / Q000008:administration & dosage / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D001453:Balsams; D004338:Drug Combinations; C062801:Granulex; D003561:Cytarabine; D002368:Castor Oil; D014357:Trypsin; D002945:Cisplatin; D006918:Hydroxyurea