Erythrocyte insulin binding in a family with hereditary motor sensory neuropathy (Charcot-Marie-Tooth) with superimposed insulin-dependent type I diabetes mellitus.
Studies on erythrocyte insulin receptors were performed in a family with hereditary motor sensory neuropathy (Charcot-Marie-Tooth) with superimposed type I diabetes mellitus. The maximum specific insulin binding of the erythrocytes was high and the increase was shown to be due to increased affinity of the insulin receptor to erythrocytes.
Ivarsson
S A
SA
Department of Pediatrics, University of Lund, Malmö General Hospital, Sweden.
Bjerre
I
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D002096:C-Peptide / Q000097:blood; D002607:Charcot-Marie-Tooth Disease / Q000097:blood* / Q000150:complications / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications / Q000235:genetics; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D009134:Muscular Atrophy, Spinal / Q000097:blood*; D011972:Receptor, Insulin / Q000378:metabolism*; D012016:Reference Values
D002096:C-Peptide; D007328:Insulin; D011972:Receptor, Insulin