Presence of a basic amino acid residue at either position 66 or 122 is a condition for enzymic activity in the ribonuclease superfamily.
Some members of the ribonuclease superfamily differ at more than 50% of the amino acid positions. Although the three-dimensional structures probably are very similar and the active-site residues have been conserved, other substrate-binding regions have changed considerably. Several proteins in the superfamily are active ribonucleases while other exhibit practically no enzymic activity. The presence of a basic residue at either position 66 or 122 appears to be a condition for ribonuclease activity.
Beintema
J J
JJ
Biochemisch Laboratorium, Groningen, The Netherlands.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D001665:Binding Sites; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011506:Proteins / Q000032:analysis; D012259:Ribonuclease, Pancreatic / Q000032:analysis*; D012260:Ribonucleases / Q000032:analysis*; D013045:Species Specificity; D014426:Turtles
D000596:Amino Acids; D011506:Proteins; D012260:Ribonucleases; C046366:angiogenin; D012259:Ribonuclease, Pancreatic