title: The Cancer Research Campaign trials of adjuvant therapy for early breast cancer.
abstract: It is now assumed that for many women there has already been dissemination of tumour at the time of diagnosis of their early breast cancer. Systemic treatment is required if a cure is sought. The use of perioperative cyclophosphamide and long-term tamoxifen, either as single agents or in combination, has been investigated in the Cancer Research Campaign Breast Adjuvant Trial. A total of 2,230 women were recruited to the study. A benefit has been seen for both agents. The implications of these results for the current treatment of women with early breast cancer and for the design of future trials are discussed.
authors.affiliation: Cancer Research Campaign Clinical Trials Centre, London, England.
authors.forename: M
authors.initials: M
authors.lastname: Baum
authors.forename: S R
authors.initials: SR
authors.lastname: Ebbs
authors.forename: J
authors.initials: J
authors.lastname: Houghton
authors.forename: R P
authors.initials: RP
authors.lastname: A'Hern
authors.forename: D
authors.initials: D
authors.lastname: Riley
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015413:Mastectomy, Simple; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D013629:Tamoxifen / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D013629:Tamoxifen; D003520:Cyclophosphamide