[Molecular aspects of the mechanism of anti-oxidant activity of vitamin E: features of the action of alpha- and gamma-tocopherol].
Current data on mechanisms of vitamin E action are reviewed with the specific reference to the antioxidant theory. Experimental data relevant to this theory on alpha- and gamma-tocopherols reactions in biological and nonbiological systems are considered. Distinctly lower biological activity of gamma-tocopherol, as compared with that of alpha-tocopherol, was shown not to depend only on dissimilar antiradical properties of these two homologues. Tocopherol-binding proteins, exhibiting high affinity only to alpha-tocopherol, appear to be responsible for realization of the biologically important reactions.
Aĭdarkhanov
B B
BB
Lokshina
E A
EA
Lenskaia
E G
EG
D000818:Animals; D000975:Antioxidants; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000187:drug effects; D051381:Rats; D014810:Vitamin E / Q000378:metabolism / Q000494:pharmacology*
D000975:Antioxidants; D005609:Free Radicals; D014810:Vitamin E
Molekuliarnye aspekty makhanizma antiokislitel'noĭ aktivnost' vitamina E: osobennosti deĭstviia alpha- i gamma-tokoferolov.