Comparative study on ethanol elimination and blood acetaldehyde between alcoholics and control subjects.
Factors influencing ethanol elimination rate and blood acetaldehyde concentration with regard to age, blood ethanol concentration, and degrees of alcoholic liver disorder were studied in alcoholic patients vis-à-vis healthy subjects. Ninety-four male alcoholic patients were divided into five groups according to age and into three groups according to blood ethanol concentration which ranged between 4.21 and 0.29 mg/ml. It was noted that as age increased, blood ethanol concentration decreased. Groups A, B, and C consisted of subjects whose ethanol levels were more than 2.5, between 1.0 and 2.5, and less than 1.0 mg/ml, respectively. Average values of ethanol elimination rate in Groups A, B, and C were 0.26, 0.23, and 0.18 mg/ml/hr, respectively. The rate increased as blood ethanol concentration elevated. The rate in Group B was significantly higher than that in the healthy control subjects who had blood ethanol levels between 1.0 and 2.5 mg/ml. The rate of ethanol elimination was independent of liver disorder judged by liver function test values. Blood acetaldehyde concentrations in the patients were less than 1.48 micrograms/ml, with an average value of 0.58 microgram/ml, and were significantly correlated with blood ethanol levels in both alcoholics and healthy subjects.
Adachi
J
J
Department of Legal Medicine, Kobe University School of Medicine, Japan.
Mizoi
Y
Y
Fukunaga
T
T
Ogawa
Y
Y
Imamichi
H
H
D000079:Acetaldehyde / Q000097:blood*; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000201:enzymology*; D000444:Aldehyde Dehydrogenase / Q000097:blood*; D000431:Ethanol / Q000493:pharmacokinetics*; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000201:enzymology; D008111:Liver Function Tests; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged
D000431:Ethanol; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde