title: Comparative trial of doxycycline plus streptomycin versus doxycycline plus rifampin for the therapy of human brucellosis.
abstract: Effectiveness and therapeutic value of the doxycycline plus streptomycin and doxycycline plus rifampin schedules of treatment of human brucellosis have been assessed by carrying out a prospective study on 111 patients randomly distributed into two groups. Patients in group A were treated with doxycycline plus streptomycin sulphate and those in group B with doxycycline plus rifampin. The temperature of all patients reverted to normal, and 54 patients from group A (91.6%) and 45 from group B (86.5%) achieved total recovery with a single therapeutic cycle. Two therapeutic failures and 3 relapses in group A (8.4%) and 7 relapses in group B (13.46%) were observed. The tolerance to both regimens was good. Although the combination doxycycline plus rifampin offers a more convenient oral administration, in the light of these results, until more extensive research is carried out, it should be considered as an alternative rather than a first choice in the treatment of human brucellosis.
authors.affiliation: Departamento Medicina Interna, Hospital Regional Carlos Haya, Malaga, Espana.
authors.forename: J D
authors.initials: JD
authors.lastname: Colmenero Castillo
authors.forename: S
authors.initials: S
authors.lastname: Hernandez Marquez
authors.forename: J M
authors.initials: JM
authors.lastname: Reguera Iglesias
authors.forename: F
authors.initials: F
authors.lastname: Cabrera Franquelo
authors.forename: F
authors.initials: F
authors.lastname: Rius Diaz
authors.forename: A
authors.initials: A
authors.lastname: Alonso
mesh_terms: D000328:Adult; D002006:Brucellosis / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use*; D013307:Streptomycin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007136:Immunoglobulins; D004318:Doxycycline; D012293:Rifampin; D013307:Streptomycin