title: [Glucose tolerance and electrolyte metabolism in nifedipine and nifedipine dihydroergotoxin treated healthy subjects].
abstract: The effects of three oral doses of nifedipine 20 mg or nifedipine 20 mg/dihydroergotoxin 2 mg (Pontuc, HN 85) during three subsequent days on an oral glucose load (100 g) were compared to placebo. Neither drug altered the glucose load or inhibited the secretion of insulin or C-peptide. The fall of serum potassium was also identical to controls. Basal plasma norepinephrine concentrations were lower following nifedipine/dihydroergotoxine than after nifedipine alone (2 p less than 0.05). A decrease of the serum sodium concentration by 2 mmol/l was observed with nifedipine but not with the combined drugs.
authors.affiliation: Abteilung Klinische Endokrinologie und Stoffwechsel der Albert-Ludwigs-Universität Freiburg/Brsg.
authors.forename: K G
authors.initials: KG
authors.lastname: Petersen
authors.forename: R
authors.initials: R
authors.lastname: Ortgiese
authors.forename: G
authors.initials: G
authors.lastname: Schuler
authors.forename: N
authors.initials: N
authors.lastname: Khalaf
authors.forename: B
authors.initials: B
authors.lastname: Schliebs
authors.forename: L
authors.initials: L
authors.lastname: Kerp
mesh_terms: D000328:Adult; D002096:C-Peptide / Q000097:blood; D004088:Dihydroergotoxine / Q000008:administration & dosage / Q000494:pharmacology*; D004573:Electrolytes / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D009638:Norepinephrine / Q000097:blood; D012083:Renin / Q000097:blood
chemical_list: D002096:C-Peptide; D004573:Electrolytes; D007328:Insulin; D004088:Dihydroergotoxine; D012083:Renin; D009543:Nifedipine; D005947:Glucose; D009638:Norepinephrine
vernacular_title: Glukose-Toleranz und Elektrolytstoffwechsel unter Nifedipin und Nifedipin-Dihydroergotoxin bei Gesunden.