Kinetic analysis of excitation-contraction coupling.
Recent studies of isolated muscle membrane have enabled induction and monitoring of rapid Ca2+ release from sarcoplasmic reticulum (SR)5 in vitro by a variety of methods. On the other hand, various proteins that may be directly or indirectly involved in the Ca2+ release mechanism have begun to be unveiled. In this mini-review, we attempt to deduce the molecular mechanism by which Ca2+ release is induced, regulated, and performed, by combining the updated information of the Ca2+ release kinetics with the accumulated knowledge about the key molecular components.
Ikemoto
N
N
Department of Muscle Research, Boston Biomedical Research Institute, Massachusetts 02114.
Ronjat
M
M
Mészáros
L G
LG
D000818:Animals; D002118:Calcium / Q000502:physiology*; D007700:Kinetics; D009119:Muscle Contraction; D009132:Muscles / Q000502:physiology*; D015388:Organelles / Q000502:physiology; D012519:Sarcoplasmic Reticulum / Q000502:physiology*; D015398:Signal Transduction
D002118:Calcium