title: Metoprolol-controlled release, zero order kinetics.
abstract: Metoprolol CR/ZOK (controlled release, zero order kinetics) is a new formulation of an extensively used beta 1-selective, beta-adrenoceptor blocking drug, (beta 1-blocker), designed to provide continuous, even, plasma concentrations in the therapeutic range. It should, therefore, provide an effective well-tolerated treatment for hypertension and angina pectoris and for use in secondary prevention following a myocardial infarct. The purpose of this review is to consider the need for such a formulation, to describe its pharmaceutical development, review its pharmacology and assess its efficacy and tolerability compared with other available agents.
authors.affiliation: Department of Pharmacology, Medical School, Birmingham, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kendall
mesh_terms: D003692:Delayed-Action Preparations; D006801:Humans; D008790:Metoprolol / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D003692:Delayed-Action Preparations; D008790:Metoprolol