title: Decreased lymphocyte function-associated antigen-1 molecule expression on peripheral blood lymphocytes from patients with Graves' disease.
abstract: Humoral and cellular abnormalities have been described in autoimmune thyroid diseases, but a deficient cooperation between humoral and cellular systems has been poorly investigated in such diseases. Lymphocyte function-associated antigen-1 (LFA-1), a glycoprotein expressed on T- and B-lymphocytes, plays an important role in cell-cell interaction mechanisms and is involved in the homing phenomenon. The expression of this molecule was investigated on peripheral blood lymphocytes from patients suffering from various thyroid disorders. Decreased numbers of LFA-1-positive cells were observed in 30 patients with Graves' disease, while normal values were present in 8 patients with Hashimoto's thyroiditis and 37 subjects with nonautoimmune thyroid disorders. Treatment-induced improvement of Graves' disease was associated with an increase in LFA-1-positive cell number.
authors.affiliation: Service d'Endocrinologie, Vandoeuvre les Nancy, France.
authors.forename: V
authors.initials: V
authors.lastname: Guerin
authors.forename: M C
authors.initials: MC
authors.lastname: Bene
authors.forename: C
authors.initials: C
authors.lastname: Amiel
authors.forename: P
authors.initials: P
authors.lastname: Hartemann
authors.forename: J
authors.initials: J
authors.lastname: Leclere
authors.forename: G
authors.initials: G
authors.lastname: Faure
mesh_terms: D000328:Adult; D000943:Antigens, Differentiation / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D006111:Graves Disease / Q000097:blood / Q000276:immunology*; D006801:Humans; D016169:Lymphocyte Function-Associated Antigen-1; D008214:Lymphocytes / Q000145:classification / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013959:Thyroid Diseases / Q000276:immunology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D000943:Antigens, Differentiation; D016169:Lymphocyte Function-Associated Antigen-1; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine