Ethanol and soluble mediators of host response.
Lymphokines serve to modulate host inflammatory response by providing a communication link among cells involved in resistance to infection. In the alcoholic, this system may be impaired due to a combination of the direct effects of ethanol on immunocompetent cells and the soluble factors involved in cell-cell interactions. In this paper, we review the literature on this subject, describe an ethanol-related impairment of migration inhibitory factor activity in the rat, and present a possible mechanism for this alteration.
Roselle
G A
GA
VA Medical Center, Cincinnati, OH 45220.
Mendenhall
C L
CL
Grossman
C J
CJ
D000437:Alcoholism / Q000276:immunology*; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects*; D007376:Interleukin-2 / Q000096:biosynthesis; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects; D008222:Lymphokines / Q000096:biosynthesis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011960:Receptors, Estrogen / Q000187:drug effects; D015375:Receptors, Interleukin-2 / Q000187:drug effects
D007376:Interleukin-2; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; D011960:Receptors, Estrogen; D015375:Receptors, Interleukin-2; D000431:Ethanol