title: Prospective, randomized trial of hypertonic sodium lactate versus lactated Ringer's solution for burn shock resuscitation.
abstract: We prospectively randomized 51 adult burned patients on admission to study fluid, electrolyte, and physiologic parameters during burn resuscitation with the use of hypertonic saline (HSL, Na 250 mEq/L, 514 mOsm) or lactated Ringer's solution (LR, Na 130 mEq/L, 268 mOsm). Patients suffered at least 20% total body surface area burns (BSA); the mean BSA injury was 36.7% BSA, with a range of 20 to 74% BSA. All patients were admitted to our Burn Center within at least 12 hours of injury. Laboratory studies included frequent determinations of serum chemistries including osmolalities, and continuous 24-hour urine collections for electrolytes and osmolality determinations. Fluid requirements (cc/kg/% BSA), urine output (cc/kg/hr), sodium intake and excretion (mEq/kg/% BSA), serum and urine osmolality (mOsm/kg), serum creatinine (mg/dl), body weight (kg), and enteral intake (cc/24 hrs and calories/24 hrs) were analyzed for comparison at 24-hour intervals following burn injury. Using Student's t-test, significance was attributed to a p less than 0.05. Nonparametric methods were used to compare non-normalized data. Regression analysis was used to compare sodium intake (mEq/kg) and fluid intake (cc/kg) between the HSL and the LR groups in relation to % BSA. Our data show no advantage of HSL over conventional therapy with LR for burn resuscitation. We were not able to demonstrate decreased fluid requirements, improved tolerance of feedings, or decrease in per cent weight gain.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Surgery, University of California, San Diego Medical Center 92103.
authors.forename: M L
authors.initials: ML
authors.lastname: Gunn
authors.forename: J F
authors.initials: JF
authors.lastname: Hansbrough
authors.forename: J W
authors.initials: JW
authors.lastname: Davis
authors.forename: S R
authors.initials: SR
authors.lastname: Furst
authors.forename: T O
authors.initials: TO
authors.lastname: Field
mesh_terms: D000328:Adult; D002056:Burns / Q000150:complications / Q000628:therapy*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage*; D007773:Lactates / Q000008:administration & dosage*; D019344:Lactic Acid; D008297:Male; D011446:Prospective Studies; D011897:Random Allocation; D012151:Resuscitation; D000077325:Ringer's Lactate; D012462:Saline Solution, Hypertonic; D012769:Shock / Q000209:etiology / Q000628:therapy*; D014882:Water-Electrolyte Balance
chemical_list: D007552:Isotonic Solutions; D007773:Lactates; D000077325:Ringer's Lactate; D012462:Saline Solution, Hypertonic; D019344:Lactic Acid