title: Effects of high frequency jet ventilation on the pulmonary clearance of 99mTc-DTPA in respiratory failure in rabbits.
abstract: The effects of high frequency jet ventilation (HFJV) at 2 and 15 Hz on the pulmonary clearance of technetium 99m diethylene triamine pentaacetate (99mTc-DTPA) were compared with conventional volume-controlled (VC) ventilation with positive end-expiratory pressure (PEEP), in a model of respiratory failure induced by two lung lavages in adult rabbits. In group 1 the lungs were ventilated with HFJV at 2 Hz, and in group 2 ventilation was with HFJV at 15 Hz; group 3 underwent conventional VC ventilation. Group 4 also had conventional ventilation, but without previous lung lavage and functioned as a control group. In all groups, mean airway pressure was maintained at a value to ensure PaO2 greater than 25 kPa. The measured half-life time (T1/2) of the 99mTc-DTPA (mean (SD] was: group 1, 28 (7.8) min; group 2, 73.5 (7.9) min; group 3, 56.5 (12.4) min and group 4, 92.6 (13.2) min. Assuming that conventional VC with PEEP ventilation causes no additional harm to surfactant depleted lungs, it is concluded that HFJV at 2 Hz leads to further damage of the lungs, whereas HFJV at 15 Hz improves reparative processes, by keeping the lungs constantly inflated.
authors.affiliation: Department of Anesthesiology, Erasmus University, Rotterdam, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Bos
authors.forename: W
authors.initials: W
authors.lastname: Schairer
authors.forename: J T
authors.initials: JT
authors.lastname: Schaffers
authors.forename: R
authors.initials: R
authors.lastname: Tenbrinck
authors.forename: A A
authors.initials: AA
authors.lastname: TenHave-Opbroek
authors.forename: W H
authors.initials: WH
authors.lastname: Bakker
authors.forename: P
authors.initials: P
authors.lastname: Wollmer
authors.forename: B
authors.initials: B
authors.lastname: Lachmann
mesh_terms: D000771:Anesthesia, Intravenous; D000818:Animals; D006611:High-Frequency Jet Ventilation / Q000009:adverse effects; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D004369:Pentetic Acid / Q000493:pharmacokinetics*; D011650:Pulmonary Alveoli / Q000473:pathology; D011817:Rabbits; D012131:Respiratory Insufficiency / Q000378:metabolism* / Q000473:pathology; D016284:Technetium Tc 99m Pentetate
chemical_list: D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate