title: The major histocompatibility complex in the chicken.
abstract: The chicken B complex is the first non-mammalian MHC characterized at the molecular level. It differs from the human HLA and murine H-2 complexes in the small size of the class I (B-F) and class II (B-L) genes and their close proximity. This proximity accounts for the absence of recombination between B-F and B-L genes and leaves no space for class III genes. Moreover the B-F and B-L genes are tightly linked to unrelated genes absent from mammalian MHCs, such as the polymorphic B-G genes and a member of the G protein beta subunit family. This linkage could form the basis for resistance to viral-induced tumors associated with some B complex haplotypes.
authors.forename: F
authors.initials: F
authors.lastname: Guillemot
authors.forename: J F
authors.initials: JF
authors.lastname: Kaufman
authors.forename: K
authors.initials: K
authors.lastname: Skjoedt
authors.forename: C
authors.initials: C
authors.lastname: Auffray
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D008040:Genetic Linkage; D008285:Major Histocompatibility Complex; D011200:Poultry / Q000235:genetics*