title: [Optimized interval treatment of eczema with fluprednidene. A multicenter double-blind study].
abstract: In a multicenter double-blind study, 44 patients suffering from eczema were bilaterally treated with 0.1% fluprednidene-21-acetate over 21 days. Continuous application twice a day was compared with intermittent therapy, i.e. 1 day intermission (15 patients), 2 days intermission (16 patients) and 3 days intermission (13 patients) using the cream base. Final evaluation was based on 11 criteria. All regimens, continuous and intermittent, proved effective (at least 90% reduction of the lesions). Treatment with 3 days intermission showed the same favorable results as continuous application, although the amount of glucocorticoids applied was 75% less. Measurements of the skin fold thickness (SFT) in healthy controls did not indicate any atrophy after treatment with fluprednidene under the same conditions as the eczema patients or under occlusion for up to 21 days. Clobetasol-17-propionate, in contrast, significantly reduced the SFT already after application of only 1 week.
authors.affiliation: Universitäts-Hautklinik Köln.
authors.forename: G
authors.initials: G
authors.lastname: Mahrle
authors.forename: U
authors.initials: U
authors.lastname: Wemmer
authors.forename: C
authors.initials: C
authors.lastname: Matthies
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001284:Atrophy; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004485:Eczema / Q000188:drug therapy*; D005260:Female; D005938:Glucocorticoids; D006801:Humans; D008297:Male; D008875:Middle Aged; D011246:Pregnadienetriols / Q000008:administration & dosage* / Q000009:adverse effects; D016032:Randomized Controlled Trials as Topic; D012867:Skin / Q000473:pathology; D012885:Skinfold Thickness
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D011246:Pregnadienetriols; C100064:fluprednidene acetate
vernacular_title: Die optimierte Intervallbehandlung des Ekzems mit Flupredniden. Eine Multizenter-Doppelblind-Studie.