title: Management of oral squamous cell carcinoma in situ with topical 5-fluorouracil and laser surgery.
abstract: Oral squamous cell carcinoma in situ has been described as a relatively rare lesion. However, difficult decisions with respect to clinical management of the lesion in this location parallel those reported for other mucosal sites, such as the cervix or the larynx. The lesion, though superficial, may extend over a large area of tissue, and attempts at irradication with surgery or radiation therapy may be associated with a great deal of morbidity. However, the risks in deferral of treatment while "watchfully waiting" may also be unacceptable. A method and rationale for management of oral squamous cell carcinoma in situ with the use of topical 5-fluorouracil and carbon dioxide laser are described in this article. A technique for using an intraoral prosthesis to potentiate drug delivery is also described. Though morbidity can be very significantly reduced, patient compliance is an important consideration for success with this protocol.
authors.affiliation: University of Michigan, Ann Arbor.
authors.forename: B B
authors.initials: BB
authors.lastname: Maxson
authors.forename: R F
authors.initials: RF
authors.lastname: Scott
authors.forename: J T
authors.initials: JT
authors.lastname: Headington
mesh_terms: D000287:Administration, Topical; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*
chemical_list: D005472:Fluorouracil