Estrogen-induced expression of mouse lactate dehydrogenase-A gene.
The synthesis of lactate dehydrogenase-A isoenzyme was shown to increase significantly in the uterus of immature mice treated by diethylstilbestrol. The expression of the mouse LDH-A promoter and cat fusion gene in Chinese hamster ovary cells was also induced by 17 beta-estradiol and diethylstilbestrol.
Li
S S
SS
Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Hou
E W
EW
D000818:Animals; D006224:Cricetinae; D003412:Cricetulus; D004054:Diethylstilbestrol / Q000494:pharmacology; D004926:Escherichia coli; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D010053:Ovary / Q000166:cytology / Q000378:metabolism; D010957:Plasmids; D011401:Promoter Regions, Genetic / Q000187:drug effects; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D014162:Transfection; D014599:Uterus / Q000166:cytology / Q000378:metabolism
D004967:Estrogens; D007527:Isoenzymes; D011993:Recombinant Fusion Proteins; D004054:Diethylstilbestrol; D007770:L-Lactate Dehydrogenase