title: Stepwise progression of kindling: perspectives from the kindling antagonism model.
abstract: What is the nature of the kindling process? We hypothesize that kindling is a discontinuous process involving discrete, stepwise transitions from one state of neural organization to another. Our data from the kindling antagonism paradigm argue that there are two critical transitions in the kindling process. These transitions constitute major steps in kindled seizure development. They act as "gates" controlling the ability of afterdischarge (AD) activity to effect the necessary reorganization of neural function which drives the kindling process. We identify two critical gates: 1) a forebrain gate which is dependent on norepinephrine (NE) and effects a discrete transition from nonconvulsive, stage 1 and 2 behaviors to stage 3 seizures, and 2) a brainstem gate which is also NE-dependent and effects a transition from stage 3 seizures to stage 4 and 5 seizures. These gates separate the kindling process into 3 "phases" which are different from, but overlap, the traditional behavioral stages of kindling defined by Racine. Current data suggest that these phases involve independent neural circuitry. They may also involve different physiological mechanisms, but this remains to be determined. This hypothesis is designed to provide a framework for the kindling process within which to search for kindling mechanisms.
authors.affiliation: Department of Neurology, University of Rochester School of Medicine, NY 14642.
authors.forename: J L
authors.initials: JL
authors.lastname: Burchfiel
authors.forename: C D
authors.initials: CD
authors.lastname: Applegate
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D007696:Kindling, Neurologic; D008959:Models, Neurological