title: Erythema elevatum diutinum: an ultrastructural case study.
abstract: An electron microscopic study was made of a patient with erythema elevatum diutinum, a rare variant of cutaneous leukocytoclastic vasculitis. Biopsies were obtained from early evolving and late fibroproliferative lesions. Early lesions showed vasculitis and a massive dermal infiltrate composed mainly of neutrophils, histiocytes/macrophages and apparently increased Langerhans cells. Later lesions were characterized by a dense fibrosis with a proliferation of fibroblasts and myofibroblasts and a dermal infiltrate in which lymphocytes and histiocytes/macrophages predominated. Even in later lesions, dermal Langerhans cells were observed in great number. Langerhans cells may be involved in the evolution of this rare disease.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: A Y
authors.initials: AY
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
authors.forename: T
authors.initials: T
authors.lastname: Nogita
authors.forename: Y
authors.initials: Y
authors.lastname: Ishibashi
mesh_terms: D004890:Erythema / Q000473:pathology*; D005355:Fibrosis; D006801:Humans; D007124:Immunoenzyme Techniques; D007801:Langerhans Cells / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000032:analysis; D012867:Skin / Q000648:ultrastructure*
chemical_list: D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins