Penetration of ceftazidime into intracranial abscess.
The penetration of ceftazidime into intracranial abscess was investigated in nine patients receiving intravenous ceftazidime. Concentrations of antibiotic in pus were measured by a microbiological agar diffusion assay (12 samples) and high performance liquid chromatography (8 samples) at varying times following ceftazidime administration. Concentrations of ceftazidime varying between 2.7 and 27.0 mg/l were detected. The role of ceftazidime in the therapy of intra-cranial abscess of otogenic origin is discussed.
Green
H T
HT
Department of Microbiology, Walton Hospital, Liverpool, UK.
O'Donoghue
M A
MA
Shaw
M D
MD
Dowling
C
C
D000328:Adult; D000368:Aged; D001922:Brain Abscess / Q000188:drug therapy / Q000378:metabolism*; D002442:Ceftazidime / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D013492:Suppuration / Q000378:metabolism
D002442:Ceftazidime