[Prevention of stomatitis induced by anti-cancer drugs].
A randomized control trial study was carried out to evaluate the effect of allopurinol mouth wash on stomatitis induced by chemotherapy in gynecologic patients. Chemotherapeutics used consisted of 5-FU+CDDP (PF) given to 10 patients and vincristine and actinomycin-D+cyclophosphamide (VAC) given to 5. Allopurinol mouth wash was prepared for patients to rinse their mouth with the solution 4-5 times daily before and after treatment with anti-cancer drugs. The Japan Society For Cancer Therapy's criteria for stomatitis were used. In the control group, stomatitis occurred in 9 of the 10 patients receiving PF therapy and in all of the 5 receiving VAC. In contrast, stomatitis was observed in only 2 of the 10 patients receiving PF therapy and 2 of the 5 VAC in the allopurinol-treated group. Allopurinol mouth wash showed a marked effect on stomatitis induced by chemotherapy.
Dozono
H
H
Dept. of Gynecology, Faculty of Medicine, Kagoshima University.
Nakamura
K
K
Motoya
T
T
Nakamura
S
S
Shinmura
R
R
Miwa
K
K
Ishibashi
M
M
Nagata
Y
Y
D000493:Allopurinol / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D003609:Dactinomycin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D005833:Genital Neoplasms, Female / Q000188:drug therapy; D006801:Humans; D009061:Mouth Mucosa; D009067:Mouthwashes; D011897:Random Allocation; D013280:Stomatitis / Q000139:chemically induced / Q000517:prevention & control*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
D009067:Mouthwashes; D003609:Dactinomycin; D014750:Vincristine; D000493:Allopurinol; D003520:Cyclophosphamide; D005472:Fluorouracil