The contribution of HLA to rheumatoid arthritis.
The contribution of genes within the major histocompatibility complex to rheumatoid arthritis has been calculated (Rotter & Landaw 1984). Separate data from hospital- and population-based studies of monozygotic twin concordance rates and sibling recurrence risks have been used, along with material from published haplotype-sharing studies. Using either source of information gives the same result, a contribution of 37%.
Deighton
C M
CM
Department of Rheumatology, Royal Victoria Infirmary, Newcastle University, Newcastle-upon-Tyne, England.
Walker
D J
DJ
Griffiths
I D
ID
Roberts
D F
DF
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D004200:Diseases in Twins; D005190:Family; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D014430:Twins, Monozygotic
D006680:HLA Antigens