Relation of serum molindone levels to serum prolactin levels and antipsychotic response.
The antipsychotic drug molindone is considered to be atypical in its mode of action and to have mild side effects. Currently no data are available on the range of serum levels of this drug during treatment. By means of a high performance liquid chromatographic technique, serum molindone levels were measured in 14 psychotic patients receiving a wide range of doses of this drug. Molindone levels as high as 350 ng/mL were obtained and were not associated with any toxic effects. Significant relations were noted between the serum level of the drug and both serum prolactin level and treatment response. The authors suggest that molindone may have a range of serum levels consistent with therapeutic benefit. Serum molindone and prolactin levels might help assess resistance to molindone treatment.
Pandurangi
A K
AK
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond.
Narasimhachari
N
N
Blackard
W G
WG
Landa
B S
BS
D000328:Adult; D001480:Basal Ganglia Diseases / Q000139:chemically induced; D002851:Chromatography, High Pressure Liquid; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007211:Indoles / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008972:Molindone / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D011388:Prolactin / Q000097:blood*; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D012559:Schizophrenia / Q000188:drug therapy; D012565:Schizophrenic Psychology
D007211:Indoles; D011388:Prolactin; D008972:Molindone