title: Pressure and flow limitations of anesthesia ventilators.
abstract: The effect of increasing airway pressure on the mean inspiratory flow and maximum minute ventilation (VE) capabilities of five anesthesia ventilators (Ohio Anesthesia, Airshields Ventimeter, Ohmeda 7000, Draeger AV-E and Siemens 900D) was compared to identify mechanical factor(s) limiting intraoperative ventilation of the lungs of patients with acute respiratory failure. The effect of increasing airway pressure on mean inspiratory flow was determined by cycling each ventilator through increasing restrictors. Maximum VE was measured under three study conditions using a test lung: 1) low compliance (10-30 ml/cmH2O) and minimal airflow resistance; 2) positive end-expiratory pressure (PEEP) of 0, 10, and 20 cmH2O at a compliance of 20 ml/cmH2O with minimal airflow resistance; and 3) increased resistance (19 +/- 11 cmH2O.1(-1).s-1) and compliance of 30 ml/cmH2O. As airway pressure increased from 0 to 80 cmH2O, mean inspiratory flow decreased markedly for all ventilators except the Siemens. The Siemens ventilator delivered the greatest VE under all three conditions and maintained VE when airway pressure increased due to decreased compliance or the application of PEEP; all other ventilators markedly decreased VE under these conditions. The addition of airway resistance reduced maximal VE for all ventilators by limiting the maximal inspiratory duty cycle (T1/TTOT). Thus, mean inspiratory flow of conventional anesthesia ventilators decreases with increasing airway pressure. The decreased inspiratory flow limits maximum VE when airway pressure is elevated because of decreased lung-thorax compliance and/or increased airway resistance, such as that characterizing patients with acute respiratory failure. Significant airway resistance further limits maximum VE by limiting the maximal T1/TTOT that can be used without increasing end-expiratory lung pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesia, University of California, San Francisco.
authors.forename: J D
authors.initials: JD
authors.lastname: Marks
authors.forename: A
authors.initials: A
authors.lastname: Schapera
authors.forename: R W
authors.initials: RW
authors.lastname: Kraemer
authors.forename: J A
authors.initials: JA
authors.lastname: Katz
mesh_terms: D000403:Airway Resistance; D000776:Anesthesiology / Q000295:instrumentation*; D005069:Evaluation Studies as Topic; D006801:Humans; D008170:Lung Compliance; D011175:Positive-Pressure Respiration; D011312:Pressure; D012123:Pulmonary Ventilation; D012122:Ventilators, Mechanical