Quantitation of renal renin and renin mRNA in Dahl rats in response to provocative stimuli.
It is known that inbred Dahl salt-sensitive (S) rats carry a different renin allele than inbred Dahl salt-resistant (R) rats. The levels of, and responses of, renal renin and renal renin mRNA to sodium deficient diet and to sodium deficient diet plus Captopril treatment were compared in S and R rats. S rats had lower renal renin and lower renal renin mRNA than R rats on control (1% NaCl) diet. Sodium deficient diet caused a modest increase, and sodium deficient diet plus Captopril caused a very large increase in both renal renin and renal renin mRNA in both strains. In general, both S and R strains appeared to regulate renin similarly in response to provocative stimuli.
Dene
H
H
Department of Medicine, Medical College of Ohio, Toledo 43699.
McIlwain
C
C
Rapp
J P
JP
D000818:Animals; D002216:Captopril / Q000494:pharmacology; D004039:Diet, Sodium-Restricted; D004198:Disease Susceptibility; D004351:Drug Resistance; D006973:Hypertension / Q000139:chemically induced / Q000235:genetics* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000235:genetics / Q000378:metabolism*; D012965:Sodium Chloride
D012333:RNA, Messenger; D012965:Sodium Chloride; D002216:Captopril; D012083:Renin