Differential effects of viqualine on alcohol intake and other consummatory behaviors.
Viqualine, a serotonin releaser and uptake inhibitor, was studied for its effects on consummatory behaviors (intake of ethanol and nonalcoholic beverages, cigarette smoking, and changes in body weight) in 29 men who were early-stage problem drinkers between 21 to 55 years of age. Subjects were randomly assigned to receive a placebo and either 100 mg/day viqualine (n = 15) or 200 mg/day viqualine (n = 14) orally in a double-blind crossover study. Viqualine administration and ethanol intake were assessed by self-reports and by measurement of drug and ethanol concentrations in body fluids. Compared with placebo, 100 mg/day viqualine did not decrease ethanol intake. However, 200 mg/day viqualine significantly decreased the total number of drinks consumed in a 14-day period (F1,12 = 5.3; p less than 0.05). An increase in the number of abstinent days was significant only for those subjects who received the placebo first (F1,6 = 11.3, p less than 0.02). Subjects reported a decreased interest in and decreased desire for alcohol during viqualine treatment. Patterns of response varied, but 64% of the subjects decreased the number of alcoholic drinks consumed and/or increased the number of days of abstinence by at least 25% during treatment with 200 mg/day viqualine compared with placebo treatment. Neither dose of viqualine had an effect on cigarette smoking or on consumption of nonalcoholic beverages, but subjects showed significant decreases in body weight with both doses. These findings indicate that viqualine both attenuates ethanol intake and reduces body weight in human beings.
Naranjo
C A
CA
Clinical Pharmacology Program, Addiction Research Foundation Clinical Institute, Toronto, Ontario, Canada.
Sullivan
J T
JT
Kadlec
K E
KE
Woodley-Remus
D V
DV
Kennedy
G
G
Sellers
E M
EM
D000328:Adult; D000428:Alcohol Drinking / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004327:Drinking Behavior / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011804:Quinolines / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D011897:Random Allocation; D012702:Serotonin Antagonists / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D012907:Smoking
D011804:Quinolines; D012702:Serotonin Antagonists; C038919:viqualine