The quantitative relationship of lethality between extracellular protease and extracellular haemolysin of Aeromonas salmonicida in Atlantic salmon (Salmo salar L.).
An additive relationship of lethality between purified protease and haemolysin of the extracellular products (ECP) of Aeromonas salmonicida was demonstrated by i.p. injection in Atlantic salmon (Salmo salar L.). The lethal toxicity of the combinations of protease and haemolysin follow a linear regression line y = -54.54x + 2400. The LD50 of protease and haemolysin when injected separately was 2400 ng/g fish and 44 ng protein/g fish, respectively.
Lee
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DAFS Marine Laboratory, Aberdeen, Scotland, U.K.
Ellis
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AE
D000333:Aeromonas / Q000032:analysis / Q000302:isolation & purification; D000818:Animals; D015153:Blotting, Western; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004591:Electrophoresis, Polyacrylamide Gel; D005109:Extracellular Matrix / Q000201:enzymology; D006460:Hemolysin Proteins / Q000302:isolation & purification / Q000633:toxicity*; D007928:Lethal Dose 50; D010447:Peptide Hydrolases / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D012474:Salmon / Q000378:metabolism*
D004338:Drug Combinations; D006460:Hemolysin Proteins; D010447:Peptide Hydrolases