title: Changes in prostaglandin renal synthesis in cardiovascular disease.
abstract: We investigated the factors able to stimulate (hormones, drugs, fluid volume changes and prostaglandin precursors) or inhibit (NSAIDs) renal prostaglandin synthesis. We then assessed the effects of NSAIDs on: A) the efficacy of certain drugs (furosemide, ACE-inhibitors), whose action is mediated by a stimulation of prostaglandin synthesis; B) the physiopathology of cardiovascular diseases such as myocardial infarction and heart failure, in which renal and circulatory output is reduced; C) arterial hypertension.
authors.forename: F
authors.initials: F
authors.lastname: Fontana
authors.forename: G
authors.initials: G
authors.lastname: Guardigli
authors.forename: M
authors.initials: M
authors.lastname: Ruffini
authors.forename: M
authors.initials: M
authors.lastname: Chiarella
authors.forename: N
authors.initials: N
authors.lastname: Spagnolo
authors.forename: C
authors.initials: C
authors.lastname: de Collibus
authors.forename: L
authors.initials: L
authors.lastname: Bastagli
authors.forename: P
authors.initials: P
authors.lastname: Bernardi
mesh_terms: D002318:Cardiovascular Diseases / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis*
chemical_list: D011453:Prostaglandins