The idiopathic polyradiculoneuropathies: a historical guide to an understanding of the clinical syndromes.
Recognition of the idiopathic polyradiculoneuropathies began with Graves, Landry and Dumenil who, respectively, suggested, implied and established the peripheral nervous system as a site of disease. Over the ensuing decades other neurologists separated the idiopathic disorders from neuropathies of known cause, poliomyelitis and myelopathies. Guillain, Barré and Strohl described the acute benign syndrome and its cerebrospinal fluid abnormalities. Haymaker & Kernohan solidified the features of the acute disorder as did Dyck et al and Prineas & McLeod for the relapsing and chronic conditions. Currently the idiopathic polyradiculoneuropathies are regarded as autoimmune in nature, clinically generalized with some cases having focal involvement, and of varying severity with only occasional fatalities. Neurologists are divided as to whether the acute and chronic disorders represent 2 different conditions or whether they are 2 forms in the spectrum of a single disorder. This author favors the concept of a single disorder with multifarious manifestations.
Horowitz
S H
SH
Department of Neurology, Long Island Jewish Medical Center, New Hyde Park, New York.
D003389:Cranial Nerve Diseases / Q000145:classification / Q000266:history* / Q000503:physiopathology; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D011129:Polyradiculoneuropathy / Q000145:classification / Q000266:history* / Q000503:physiopathology