Cutaneous reactions to drugs used for rheumatologic disorders.
Cutaneous reactions to medications probably represent the most common manifestation of drug reactions. The diversity of cutaneous eruptions produced by drugs provide a challenge in searching for the mechanisms producing the reaction. Many eruptions are due to a form of allergic hypersensitivity, while others may be idiosyncratic, due to a metabolic abnormality, or represent a cumulative phenomenon. This article discusses the diagnosis of drug-induced cutaneous reactions by reviewing specific drugs commonly used in rheumatologic therapy.
Roth
D E
DE
Department of Dermatology, University of Louisville School of Medicine, Kentucky.
Spencer
L V
LV
Ahrens
E M
EM
D000085:Acetates / Q000009:adverse effects / Q000627:therapeutic use; D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000962:Antimalarials / Q000009:adverse effects / Q000627:therapeutic use; D000963:Antimetabolites / Q000009:adverse effects / Q000627:therapeutic use; D003524:Cyclosporins / Q000009:adverse effects / Q000627:therapeutic use; D006046:Gold / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D010396:Penicillamine / Q000009:adverse effects / Q000627:therapeutic use; D010894:Piroxicam / Q000009:adverse effects / Q000627:therapeutic use; D011422:Propionates / Q000009:adverse effects / Q000627:therapeutic use; D011720:Pyrazoles / Q000009:adverse effects / Q000627:therapeutic use; D012176:Retinoids / Q000009:adverse effects / Q000627:therapeutic use; D012216:Rheumatic Diseases / Q000188:drug therapy; D012459:Salicylates / Q000009:adverse effects / Q000627:therapeutic use; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D062367:ortho-Aminobenzoates / Q000009:adverse effects / Q000627:therapeutic use
D000085:Acetates; D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D000962:Antimalarials; D000963:Antimetabolites; D003524:Cyclosporins; D011422:Propionates; D011720:Pyrazoles; D012176:Retinoids; D012459:Salicylates; D062367:ortho-Aminobenzoates; D010894:Piroxicam; D006046:Gold; D010396:Penicillamine