title: Clinical, histologic and scanning electron microscopic study of the development of chronic candidiasis of the rat tongue.
abstract: In order to examine the development of the chronic candidal lesion of the dorsal rat tongue, 210 rats were given a single oral inoculum of Candida albicans on Day 0 and were sequentially killed over a 20-wk period. Dorsal tongue changes were evaluated using clinical photographs, histologic sections and scanning electron microscopy (SEM). Clinically evident lesions became apparent at 2 wk post-inoculation, and inflammatory changes of the underlying connective tissue were observed by 3 wk post-inoculation. SEM showed a gradient of destruction of the dorsal tongue papillae at the periphery of the candidal lesions. Hyphae were seen infrequently on the lesional surface by SEM, a finding which correlated with the light microscopy.
authors.affiliation: Ohio State University College of Dentistry, Columbus 43210.
authors.forename: C M
authors.initials: CM
authors.lastname: Allen
authors.forename: R
authors.initials: R
authors.lastname: Paulson
authors.forename: R
authors.initials: R
authors.lastname: Duncan
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000648:ultrastructure; D002180:Candidiasis, Oral / Q000473:pathology*; D004848:Epithelium / Q000473:pathology; D005260:Female; D005928:Glossitis / Q000473:pathology*; D008855:Microscopy, Electron, Scanning; D051381:Rats; D011919:Rats, Inbred Strains; D014059:Tongue / Q000473:pathology