[Enhancement of cancer growth and metastasis by host reactive cells and their secreting factors].
Proliferation and metastasis of cancer are affected by the interactions between cancer cells and the host cells; in particular, host reactive cells regulate proliferation and metastasis or cancer cells directly through various soluble factors. However, recent studies revealed that cytokines and growth factors released by macrophages and lymphocytes promote proliferation and metastasis of cancer cells, whereas they act for controlling infection or healing wounds. For example, transforming growth factor (TGF) released by lymphocytes and macrophages induces transformation of normal cells to malignant cells; and TGF-alpha promotes the production of PDGF & TGF-beta, which results in the proliferation of cancer cells. It is also known that TGF-beta suppresses proliferation of T.B lymphocytes and production of TNF-alpha. Oxygen radicals are also considered to be involved in the transformation that cancer cells increase their malignancy. This paper will deal with the host-tumor interactions, introducing our experimental results.
Takeichi
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Laboratory of Pathology, Hokkaido University School of Medicine.
D000818:Animals; D006224:Cricetinae; D005609:Free Radicals; D006133:Growth Substances / Q000378:metabolism* / Q000502:physiology; D006789:Host vs Graft Reaction; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D015291:Transforming Growth Factors / Q000378:metabolism / Q000502:physiology
D005609:Free Radicals; D006133:Growth Substances; D015291:Transforming Growth Factors; D010100:Oxygen