title: Cytochrome P-450 catalysis: radical intermediates and dehydrogenation reactions.
abstract: Cytochrome P-450 appears to catalyse most monooxygenation reactions by sequential one-electron steps rather than by a single, concerted transfer of the ferryl oxygen to the substrate. The radical intermediates, although very short-lived, can rearrange or undergo alternative reactions characteristic of radical species. As Paul Ortiz de Montellano explains, these alternative reactions yield novel metabolites, sometimes result in inactivation of the enzyme, and can provide information on the reaction mechanism.
authors.forename: P R
authors.initials: PR
authors.lastname: Ortiz de Montellano
mesh_terms: D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005609:Free Radicals; D006865:Hydrogenation
chemical_list: D005609:Free Radicals; D003577:Cytochrome P-450 Enzyme System