Interleukin-6 induced at mucosal surfaces by gram-negative bacterial infection.
Interleukin-6 (IL-6) was produced in response to mucosal and systemic infection of mice with gram-negative bacteria. The IL-6 response was controlled by the lipopolysaccharide gene, Lps; in C3H/HeN mice (Lpsn/Lpsn), the urinary IL-6 levels increased within 30 min after challenge with Escherichia coli, but no response occurred in C3H/HeJ mice (Lpsd/Lpsd). In lipopolysaccharide-responder mice, the levels of local and systemic IL-6 were related to the degree of infection. The urinary response dominated after intravesical challenge, and the serum response dominated after intraperitoneal challenge. The results demonstrate that IL-6 is activated as part of lipopolysaccharide-induced mucosal and systemic responses to gram-negative bacterial infections.
de Man
P
P
Department of Clinical Immunology, University of Göteborg, Sweden.
van Kooten
C
C
Aarden
L
L
Engberg
I
I
Linder
H
H
Svanborg Edén
C
C
D000818:Animals; D004927:Escherichia coli Infections / Q000235:genetics / Q000382:microbiology / Q000503:physiopathology*; D005796:Genes; D007375:Interleukin-1 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000652:urine; D007668:Kidney / Q000382:microbiology; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008809:Mice, Inbred C3H; D009092:Mucous Membrane / Q000276:immunology / Q000382:microbiology; D013997:Time Factors; D001743:Urinary Bladder / Q000382:microbiology; D014552:Urinary Tract Infections / Q000382:microbiology / Q000503:physiopathology*
D007375:Interleukin-1; D015850:Interleukin-6; D008070:Lipopolysaccharides