An immunohistochemical study of beta-protein in Alzheimer-type dementia brains.
An immunohistochemical study with a polyclonal anti-beta-protein antiserum was performed in order to understand the mechanism of deposition of amyloid fibrils in senile plaques in Alzheimer-type dementia (ATD). Serial cortical sections cut from ATD brains were necessary to investigate the structural correlation between senile plaques and blood vessels. The senile plaques were stained well and a blood vessel or capillary-like structure was found in most of beta-protein-immunoreactive deposits. These findings may suggest an involvement of blood vessels in the formation of at least some of the amyloid deposits in ATD brains.
Arai
H
H
Department of Psychopharmacology, Psychiatric Research Institute of Tokyo, Japan.
Sagi
N
N
Noguchi
I
I
Haga
S
S
Ishii
T
T
Makino
Y
Y
Kosaka
K
K
D000544:Alzheimer Disease / Q000378:metabolism*; D000682:Amyloid / Q000032:analysis*; D016229:Amyloid beta-Peptides; D001923:Brain Chemistry; D002196:Capillaries / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D009419:Nerve Tissue Proteins / Q000032:analysis*
D000682:Amyloid; D016229:Amyloid beta-Peptides; D009419:Nerve Tissue Proteins