Effect of orally-administered epidermal growth factor on intestinal iron absorption and mucosal permeability.
A progressive increase in intestinal 59Fe3+ absorption was observed on oral feeding of mice with physiological doses of EGF/UGO. Maximal changes were apparent after 3d and appeared to be dose-dependent. In addition to a small increase in intestinal cell proliferation, as reflected by increased ornithine decarboxylase activity, EGF/UGO-feeding increased mucosal permeability (evaluated with [51Cr]-EDTA): the latter could account for the increase in iron absorption. Sialoadenectomy, to remove the major source of endogenous EGF/UGO, had no appreciable effect on the intestinal absorption of iron.
Raja
K B
KB
Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middlesex, U.K.
Simpson
R J
RJ
Gregory
H
H
Peters
T J
TJ
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000008:administration & dosage* / Q000502:physiology; D004909:Erythrocyte Indices / Q000187:drug effects; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009955:Ornithine Decarboxylase / Q000378:metabolism; D013363:Submandibular Gland / Q000502:physiology; D000520:alpha-Glucosidases / Q000378:metabolism
D004815:Epidermal Growth Factor; D007501:Iron; D000520:alpha-Glucosidases; D009955:Ornithine Decarboxylase