title: Multinucleated giant cells on Bruch's membrane late in recurrent retinal and subretinal hemorrhaging.
abstract: Two cases with a history of recurrent subretinal hemorrhaging are reported. Multinucleated giant cells of macrophage origin were demonstrated on Bruch's membrane in a few stages of their functions of phagocytosis of old blood and storage of blood remnants. Their classification as foreign-body giant cells fails to recognize the important purification, disposal and storage functions of these cells in situations with extensive intraocular hemorrhage, exudation or necrosis.
authors.affiliation: Department of Ophthalmology, University of Michigan Hospitals, Ann Arbor.
authors.forename: J R
authors.initials: JR
authors.lastname: Wolter
authors.forename: G O
authors.initials: GO
authors.lastname: Till
mesh_terms: D002829:Choroid / Q000473:pathology*; D002830:Choroid Neoplasms / Q000150:complications; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology*; D015726:Giant Cells / Q000473:pathology*; D015743:Giant Cells, Foreign-Body / Q000473:pathology* / Q000502:physiology; D015745:Granuloma, Foreign-Body / Q000473:pathology*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000150:complications; D008566:Membranes / Q000473:pathology; D008875:Middle Aged; D010587:Phagocytosis; D012008:Recurrence; D012163:Retinal Detachment / Q000150:complications; D012166:Retinal Hemorrhage / Q000473:pathology*; D012170:Retinal Vein Occlusion / Q000150:complications; D014792:Visual Acuity