title: Anterior and posterior pituitary function in brain-stem-dead donors. A possible role for hormonal replacement therapy.
abstract: Blood samples were obtained, at the time of organ donation, from 31 consecutive brain-stem-dead (BSD) donors referred to one transplant coordinator during a 9-month period. Twenty-four cases (77%) had clinical diabetes insipidus (DI), which was poorly controlled with marked dehydration in a majority of cases (serum osmolality range 268-357; median 302 mOSM/kg). Serum triiodothyronine (T3) was subnormal in 25 (81%); all had normal or high serum reverse T3; and the serum free thyroxine (T4) index was subnormal in 9 (29%), and TSH was subnormal in 7 (23%). In no case were T4 and TSH both subnormal and results were typical of the sick euthyroid syndrome rather than TSH deficiency. Of 21 cases not receiving corticosteroids, 5 (24%) had a serum cortisol above 550 nmol/L (20 micrograms/dl), excluding ACTH deficiency, and only 1 had undetectable cortisol levels. Those with severe hypotension did not have significantly lower serum cortisol (mean 354 vs. 416; P greater than 0.5). Levels of prolactin, growth hormone, gonadotrophins, and gonadal steroids were variable, but only a minority were frankly deficient in these hormones. BSD donors frequently have DI, which is often managed poorly by nonspecialists and requires appropriate replacement therapy. In contrast most patients are not totally deficient in anterior pituitary hormones. Routine hormonal therapy with cortisol and T3 cannot, therefore, be justified on endocrinological grounds. Widespread introduction of such treatment should only follow controlled trials that clearly demonstrate clinically significant improvement in the transplanted organ function, without detriment to the donor.
authors.affiliation: Department of Endocrinology, St Bartholomew's Hospital, London, United Kingdom.
authors.forename: T A
authors.initials: TA
authors.lastname: Howlett
authors.forename: A M
authors.initials: AM
authors.lastname: Keogh
authors.forename: L
authors.initials: L
authors.lastname: Perry
authors.forename: R
authors.initials: R
authors.lastname: Touzel
authors.forename: L H
authors.initials: LH
authors.lastname: Rees
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001926:Brain Death; D001933:Brain Stem / Q000503:physiopathology; D002648:Child; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010903:Pituitary Gland, Anterior / Q000503:physiopathology*; D010904:Pituitary Gland, Posterior / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D006065:Gonadotropins, Pituitary; D006728:Hormones; D013963:Thyroid Hormones; D003894:Deamino Arginine Vasopressin; D006854:Hydrocortisone