Effects of central administration of insulin in normal and VMH (ventromedial hypothalamus) lesioned rats on food intake.
Central effects of insulin on 20 min. food intake were studied in rats. Insulin administration in the lateral ventricular cerebrospinal fluid (CSF) did not alter food intake in the intact or lesioned ventromedial hypothalamus (VMH) rats. Whereas, after insulin injection in VMH there was a decrease in food intake. In VMH lesioned rats, subcutaneous injection of insulin increased food intake.
Thombre
D P
DP
Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry.
Bharathi
S
S
Krishnamurthy
N
N
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000502:physiology*; D007276:Injections, Intraventricular; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D014697:Ventromedial Hypothalamic Nucleus / Q000502:physiology*
D007328:Insulin