Effect of sodium artesunate on malaria infected human erythrocytes.
Oxidative stress in malaria infected human erythrocytes is augmented and the anti-oxidant system is attenuated as compared with normal RBC's. Exacerbation of intra-erythrocytic oxidative stress might provide a means to kill the parasites. Sodium artesunate (SA), an effective Chinese anti-malaria drug, markedly increased the levels of active oxygen species and production of malonyldialdehyde in normal red blood cells and, to a greater extent, in malaria infected red blood cells. SA caused a remarkable decrease of unsaturated fatty acids content in normal red blood cell membrane. These suggest that the anti-oxidative system in red blood cells infected with malaria is jeopardized. Certain active oxygen species generated and accumulated in such red blood cells might in turn kill the parasites. SA augmented intracellular O2-. and H2O2 production, and this may partly account for its antimalaria action.
Pan
H Z
HZ
Lin
F B
FB
Zhang
Z A
ZA
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D000975:Antioxidants; D037621:Artemisinins; D000077332:Artesunate; D002478:Cells, Cultured; D004912:Erythrocytes / Q000378:metabolism* / Q000469:parasitology; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D010100:Oxygen / Q000378:metabolism; D010963:Plasmodium falciparum / Q000254:growth & development*; D012717:Sesquiterpenes / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
D000962:Antimalarials; D000975:Antioxidants; D037621:Artemisinins; D012717:Sesquiterpenes; D000077332:Artesunate; D013482:Superoxide Dismutase; D010100:Oxygen