Stimulation of hematopoiesis and antibacterial resistance by interleukin-1.
The beneficial effects of IL-1 and other cytokines on hematopoiesis and on resistance to infection are profound. IL-1 stimulates proliferation of bone marrow cells in normal mice and potentiates the recovery of peripheral blood neutrophils in mice with drug-induced neutropenia. Prophylactic cytokine administration provides an elevated level of natural resistance to infections which is correlated with increased numbers of phagocytic leukocytes. These studies suggest that IL-1 has potential clinical application as a therapy to limit bone marrow dysfunction and immunosuppression and to augment hematopoiesis and natural immunity. Further research will continue to elucidate the mechanisms whereby interleukins and colony-stimulating factors act, and interact, to promote restoration of leukocyte production and to enhance host resistance.
McIntyre
K W
KW
Roche Research Center, Hoffmann-LaRoche Inc., Nutley, NJ 07110.
Unowsky
J
J
DeLorenzo
W
W
Tare
N S
NS
Plocinski
J M
JM
Benjamin
W R
WR
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D007375:Interleukin-1 / Q000494:pharmacology*; D051379:Mice; D013268:Stimulation, Chemical
D007375:Interleukin-1