title: Membranoproliferative glomerulonephritis in a patient with congenital deficiency of the third component of complement: effect of treatment with plasma.
abstract: A 21-year-old woman with a known congenital complement component 3 (C3) deficiency developed membranoproliferative glomerulonephritis. The kidney biopsy exhibited deposits of immunoglobulins and complement components despite the C3 deficiency. The administration of fresh frozen plasma was without therapeutic benefit. Corticosteroid treatment was followed by an improvement in kidney function.
authors.affiliation: University Hospital for Children and Youth, Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Roord
authors.forename: R A
authors.initials: RA
authors.lastname: van Diemen-van Steenvoorde
authors.forename: H J
authors.initials: HJ
authors.lastname: Schuurman
authors.forename: G T
authors.initials: GT
authors.lastname: Rijkers
authors.forename: B J
authors.initials: BJ
authors.lastname: Zegers
authors.forename: F H
authors.initials: FH
authors.lastname: Gmelig Meyling
authors.forename: J W
authors.initials: JW
authors.lastname: Stoop
mesh_terms: D000328:Adult; D001706:Biopsy; D001803:Blood Transfusion; D003176:Complement C3 / Q000172:deficiency*; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007668:Kidney / Q000473:pathology; D010949:Plasma; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D003176:Complement C3; D011241:Prednisone