Breakdown of the blood--aqueous barrier in the rabbit eye by infrared radiation.
Breakdown of the blood-aqueous barrier was produced by infrared radiation (IR) at a heat flux from 24 to 44 J/cm2 in pigmented, but not in albino rabbits. Blood-aqueous barrier breakdown was inhibited by indomethacin and ketamine/xylazine anesthesia mixtures, but not by [D-Trp2,D-Pro7,9]-substance P. The degree of blood-aqueous barrier breakdown could be controlled by IR flux. Two models for accurate determination of the heat flux are presented.
Kurnik
R T
RT
Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri.
Burde
R M
RM
Becker
B
B
D000417:Albinism / Q000378:metabolism; D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D001769:Blood / Q000378:metabolism*; D005123:Eye / Q000098:blood supply / Q000378:metabolism*; D005136:Eye Proteins / Q000378:metabolism; D019793:Fluorescein; D005452:Fluoresceins; D005470:Fluorometry; D007213:Indomethacin / Q000494:pharmacology; D007259:Infrared Rays; D010783:Photometry; D010858:Pigmentation; D011817:Rabbits
D000777:Anesthetics; D005136:Eye Proteins; D005452:Fluoresceins; D019793:Fluorescein; D007213:Indomethacin