Changes of lipofuscin-like pigments in erythrocytes and spleen after whole-body gamma irradiation of rats.
Whole-body gamma irradiation of rats induced the formation of lipofuscin-like pigments in erythrocytes. Erythrocytes that were damaged by oxidation were scavenged in the spleen, and lipofuscin-like pigments were transferred from erythrocytes to the spleen during this process. The time course of lipofuscin-like pigments in erythrocytes and spleen indicates that the pigments were not induced by the action of free radicals produced by ionizing radiation but rather were a sequela of postirradiation metabolic changes.
Wilhelm
J
J
Laboratory for Endocrinology and Metabolism, Charles University, Praha, Czechoslovakia.
Brzák
P
P
Rejholcová
M
M
D000818:Animals; D015415:Biomarkers; D003037:Cobalt Radioisotopes; D004912:Erythrocytes / Q000378:metabolism / Q000528:radiation effects*; D005720:Gamma Rays; D008062:Lipofuscin; D008297:Male; D010860:Pigments, Biological / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000378:metabolism / Q000528:radiation effects*; D014916:Whole-Body Irradiation
D015415:Biomarkers; D003037:Cobalt Radioisotopes; D008062:Lipofuscin; D010860:Pigments, Biological