[The effect of hydrocortisone and dopamine on the activity of some lysosomal liver enzymes in experimental endotoxic shock].
The influence of hydrocortisone and dopamine to the course of the organic functional changes and the activity of same lysosomal hepatic enzymes were tested in 30 dogs in endotoxic shock. A continuous lowering of the blood pressure and the central venous pressure were observed in the non-treated group. The hemodynamic impairments turned out in the treated groups in a less acute course. The coupled treatment with hydrocortisone and dopamine in the experimental endotoxic shock seems to reduce the activity of the lysosomal enzymes in the liver and in the peripheral blood.
Trochimowicz
L
L
Klinik für allgemeine Chirurgie, Medizinischen Akademie in Białystok, Polen.
Puchalski
Z
Z
Barczyk
J
J
Ladny
J R
JR
D000135:Acid Phosphatase / Q000097:blood / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure; D002403:Cathepsins / Q000097:blood / Q000378:metabolism; D002496:Central Venous Pressure; D004285:Dogs; D004298:Dopamine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006854:Hydrocortisone / Q000627:therapeutic use*; D008247:Lysosomes / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology; D012772:Shock, Septic / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology
D000135:Acid Phosphatase; D002403:Cathepsins; D004298:Dopamine; D006854:Hydrocortisone
Einfluss des Hydrokortisons und Dopamins auf die Aktivität einiger lysosomaler Leberenzyme im experimentellen Endotoxinschock.