[Study of mechanisms of neurotropic action of middle molecular weight peptides in the blood of intact blood and dogs with burns].
The authors studied the role of changes of lipid peroxidation and monoamine oxidase activity in the brain of mice under the effect of various fractions of middle-mass peptides (MMP) obtained from blood of intact dogs and dogs with burns. A marked neurotropic effect of MMP was manifested by changes of the behavior of rats in the "open field". The blood of dogs with burns was found to contain an MMP fraction whose neurotropic effect was caused by changes of the monoamine oxidase activity of the brain. The results bear evidence that the prooxidant action of MMP of blood of intact animals on brain tissue is associated with the neurotropic effect of these compounds. The data obtained is discussed from the standpoint of burn encephalopathy.
Volchegorskiĭ
I A
IA
Val'dman
B M
BM
Puzhevskiĭ
A S
AS
Lifshits
R I
RI
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D002056:Burns / Q000097:blood*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D008970:Molecular Weight; D008995:Monoamine Oxidase / Q000378:metabolism; D010455:Peptides / Q000097:blood / Q000494:pharmacology*
D010455:Peptides; D008995:Monoamine Oxidase
Issledovanie mekhanizmov neĭtrotropnogo deĭstviia srednemolekuliarnykh peptidov krovi intaktnykh i obozhzhennykh sobak.