Clinical value of deconvolution analysis in radionuclide renal study.
Deconvolution analysis was applied to radionuclide renal study. The purpose of this study was to clarify the underlying renal physiology that determines the shape and values of the transfer function. Analysis of the renal models revealed that the initial height of the transfer function is the ratio of the radioactivity extracted by the kidney to that in the input function. In addition, the shape of the transfer function displayed the distribution of the transit times and enabled us to evaluate the percentage of nephrons having a particular transit time. Based on the relation between the input and output function, a new method for measuring GFR or ERPF was developed in which the input function was corrected by the plasma radioactivity at 5 min after injection of the tracer. As one of the advantages of the transfer function, it was proved clinically that the contribution of the blood background is automatically eliminated from the amplitude of the transfer function. From these findings, our method for the measurement of GFR was considered superior to that proposed by Gates and highly useful for routine radionuclide renal study.
Nakagawa
T
T
Department of Radiology, School of Medicine, Mie University, Japan.
Maeda
H
H
Terada
N
N
Ono
M
M
Ohi
M
M
Ito
T
T
Takeda
K
K
Tagami
T
T
Matsushita
T
T
D005919:Glomerular Filtration Rate; D006626:Hippurates; D006801:Humans; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging / Q000503:physiopathology; D007457:Iodine Radioisotopes; D007668:Kidney / Q000503:physiopathology; D008432:Mathematical Computing; D008954:Models, Biological; D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D011866:Radioisotope Renography; D012079:Renal Circulation; D016284:Technetium Tc 99m Pentetate
D006626:Hippurates; D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D004369:Pentetic Acid; C030514:hippuric acid; D016284:Technetium Tc 99m Pentetate