A case-control study of cancer among du pont employees with potential for exposure to dimethylformamide.
This case-control study was undertaken to determine whether the risk of developing cancers of the buccal cavity and pharynx (N = 39), liver (N = 6), prostate (N = 43), testis (N = 11), or malignant melanoma of the skin (N = 39) is related to exposure to dimethylformamide (DMF). Case and control subjects were obtained from four Du Pont plants. DMF is produced at one plant and used at the other three. Cancer cases identified from the company Cancer Registry comprise those reported among active male employees at the study plants during 1956 to 1985. For each case, two control subjects were selected, matched on sex, payroll class (wage or salary), birth year, and plant. To determine whether an employee could have been exposed to DMF during his career at the plant, all jobs with potential for exposure to DMF were identified. Each job was assigned an exposure ranking based on DMF industrial hygiene air monitoring, DMF metabolite (measured as N-methylformamide in urine) monitoring, and knowledge of the evolution of manufacturing processes and workplace exposure controls. Each employee's DMF exposure pattern was then characterized as (a) ever v never having been exposed to DMF and (b) highest DMF exposure experienced. Summary analyses for all plants combined showed no statistically significant association between ever having been exposed to DMF and subsequent development of cancers of the buccal cavity and pharynx, liver, malignant melanoma, prostate, and testis. Examined by plant site, prostate cancer at one plant was significantly elevated, based on three case subjects exposed out of four.(ABSTRACT TRUNCATED AT 250 WORDS)
Walrath
J
J
E. I. Du Pont de Nemours and Company, Wilmington, DE 19898.
Fayerweather
W E
WE
Gilby
P G
PG
Pell
S
S
D000328:Adult; D000368:Aged; D002617:Chemical Industry; D015331:Cohort Studies; D004126:Dimethylformamide / Q000009:adverse effects* / Q000652:urine; D005069:Evaluation Studies as Topic; D005153:Facial Neoplasms / Q000139:chemically induced / Q000652:urine; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced / Q000652:urine; D008297:Male; D008545:Melanoma / Q000139:chemically induced / Q000652:urine; D008875:Middle Aged; D009369:Neoplasms / Q000139:chemically induced* / Q000652:urine; D009784:Occupational Diseases / Q000139:chemically induced* / Q000652:urine; D010610:Pharyngeal Neoplasms / Q000139:chemically induced / Q000652:urine; D011471:Prostatic Neoplasms / Q000139:chemically induced / Q000652:urine; D012044:Regression Analysis; D012307:Risk Factors; D012494:Sampling Studies; D012878:Skin Neoplasms / Q000139:chemically induced / Q000652:urine; D013736:Testicular Neoplasms / Q000139:chemically induced / Q000652:urine; D013997:Time Factors
D004126:Dimethylformamide