[Acute peptic lesions of the gastroduodenal mucosa in patients with obstructive jaundice].
Complex study of the gastric acid-producing activity, the condition of the gastroduodenal mucosa, and the serum gastrin concentration in 80 patients with obstructive jaundice showed that the appearance of acute erosive-ulcerative injuries of the mucosa of the gastroduodenal zone depended on the increase of activity of the peptic factor of the gastric medium. Peptic complications occurred in 27.1% of patients with initial normo and hyperacidity and a high level of blood gastrin. The absence of bile in the duodenum (obstructive jaundice, by-pass biliodigestive anastomoses) stimulated the peptic factor. This is evidently linked with secretin deficiency (absence of the effect of bile on the secretin producing S-cells) leading to weakened inhibiting effect of secretin on the serum gastrin content, which results in hypergastrinemia and hyperacidity.
Upyrev
A V
AV
Gusev
E Iu
EIu
Il'ichev
V A
VA
Gorchakov
V K
VK
Muratova
O A
OA
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002779:Cholestasis / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000209:etiology*
Ostrye pepticheskie porazheniia slizistoĭ gastroduodenal'noĭ zony u bol'nykh s obturatsionnoĭ zheltukhoĭ.