title: Risk stratification and management of patients with recurrent ventricular tachycardia and other malignant ventricular arrhythmias.
abstract: Clinical results are reviewed in 269 patients who underwent subendocardial resection for recurrent sustained ventricular tachycardia secondary to ischemic heart disease. Operative mortality is 15%. Factors increasing operative mortality rates are ejection fraction less than 20%, emergency operation, and history of previous heart operation. Use of amiodarone preoperatively does not alter operative risk. Clinical control of ventricular tachycardia is achieved in 93% of operative survivors. Two thirds of these patients do not need antiarrhythmic agents. Five-year actuarial survival is approximately 60%. Patient results with the automatic internal cardioverter defibrillator at the Hospital of the University of Pennsylvania and nationwide are also reviewed. As of June 1987, almost 1,500 patients had one or more devices implanted. Most patients had a prior documented cardiac arrest. Coronary artery disease is the cause of heart disease in over 70% of patients. Operative mortality is low (0.8-3.9%). Approximately 50% of patients have had therapeutic discharge of the device; however, asymptomatic discharge occurs in up to 45% of patients. Incidence of sudden death is 1.5% at 1 year and 5% at 5 years. Five-year actuarial survival is approximately 60%. Long-term mortality is primarily from heart failure.
authors.affiliation: Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104.
authors.forename: W C
authors.initials: WC
authors.lastname: Hargrove
authors.forename: J M
authors.initials: JM
authors.lastname: Miller
mesh_terms: D000206:Actuarial Analysis; D000638:Amiodarone / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures / Q000401:mortality*; D004554:Electric Countershock / Q000295:instrumentation*; D004699:Endocardium / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013610:Tachycardia / Q000601:surgery*
chemical_list: D000638:Amiodarone