Serum erythropoietic activity in acute anemia--an animal model.
Serum erythropoietic activity and reticulocyte response to anemia were investigated using a rabbit model. In hemolytic anemia, induced by injections of phenylhydrazine on Day 0 the hemoglobin reached a nadir (mean, 6.23 g/dl) on Day 4 when SEA was maximal (mean, 765 mU/ml). In animals venesected on Day 0 and Day 1 to produce anemia of equal severity, the SEA was maximal (mean 235 mU/ml) on Day 2. In both groups the reticulocyte response peaked on Day 7--at 34% for the hemolytic group and 21% for the venesected group. The 2,3-diphosphoglycerate, measured on Day 4, was significantly reduced in the PHZ-treated group. In the venesected group the 2,3-DPG increased between Day 0 and Day 4. There were no concurrent changes in acid-base balance. These results imply that the degree of anemia is only one of the factors which influence the level of circulating SEA.
McMullin
M F
MF
Department of Haematology, Royal Victoria Hospital, Belfast, Northern Ireland.
Lappin
T R
TR
Elder
G E
GE
Taylor
T
T
Bridges
J M
JM
D000208:Acute Disease; D000743:Anemia, Hemolytic / Q000097:blood*; D000818:Animals; D004195:Disease Models, Animal; D004920:Erythropoiesis; D006454:Hemoglobins / Q000032:analysis; D010659:Phenylhydrazines / Q000494:pharmacology; D011817:Rabbits
D006454:Hemoglobins; D010659:Phenylhydrazines