Dynamic properties of interaction between nucleic acid bases and models of amino acids.
We have discussed the possible hydrogen bonding mode of adenine-uracil base dimers and peptide side chains, together with their characteristic effects on the stability of adenine-uracil base pairing in chloroform solution by using proton nuclear magnetic resonance methods, where acetamide and butyric acid were used as a model of residues of glutamine and glutamic acid, respectively, and were added to an adenine-uracil equimolar mixture. The stability of base pairing was affected significantly when the model compounds approached the adenine-uracil base pairs; that is, the Hoogsteen type was destroyed, while the Watson-Crick type was formed more favorably.
Yu
B S
BS
Laboratory of Physical Pharmacy, College of Pharmacy, Seoul National University, Korea.
Sohn
D H
DH
Goo
G
G
D000081:Acetamides; D000225:Adenine / Q000031:analogs & derivatives*; D000596:Amino Acids; D001482:Base Composition; D002087:Butyrates; D020148:Butyric Acid; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008962:Models, Theoretical; D015394:Molecular Structure; D014498:Uracil / Q000031:analogs & derivatives*
D000081:Acetamides; D000596:Amino Acids; D002087:Butyrates; D020148:Butyric Acid; C001172:9-ethyladenine; D014498:Uracil; C000538:1-cyclohexyluracil; C030686:acetamide; D000225:Adenine