Evidence that SE is distal to LU on chromosome 19q.
Analysis of a family informative for chromosome 19 loci establishes that the Lutheran blood group locus (LU) lies between the third component of human complement (C3) and the secretor loci (SE). Previously published lod scores for C3:LU are increased from 2.94 to 3.80. The linkage relationships (zeta and theta) between C3, LU, and SE are examined, and the proposed order and approximate genetic distances are determined to be: pter--C3-10.6cM-cen-7.4cM-LU-9cM-SE--qter.
Zelinski
T
T
Department of Pediatrics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Coghlan
G
G
Greenberg
C R
CR
McAlpine
P J
PJ
Lewis
M
M
D002888:Chromosomes, Human, Pair 19; D003176:Complement C3 / Q000235:genetics; D008040:Genetic Linkage; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000235:genetics*; D008126:Lod Score; D008188:Lutheran Blood-Group System / Q000235:genetics*; D010375:Pedigree
D003176:Complement C3; D007983:Lewis Blood Group Antigens; D008188:Lutheran Blood-Group System