title: Deleterious effects of shock in internal mammary artery anastomoses.
abstract: Internal mammary arteries (IMAs) are increasingly used for coronary artery revascularization. However, spastic reactions after IMA-coronary artery anastomoses have been reported. Internal mammary artery flow and the effects of sudden hypovolemia, gradual hypovolemia, papaverine hydrochloride, nitrates, and epinephrine were evaluated in a canine model (n = 10) (body weight, 19 +/- 5 kg) without interference from coronary artery resistance by dissecting the IMA as a pedicle, calibrating the flowmeter during free IMA flow, and anastomosing the IMA to the right atrium. Sudden hypovolemia (withdrawal of 20% of circulating blood volume over 90 seconds) caused significant modifications (p less than 0.01) of the following hemodynamic variables: heart rate (+12%), right atrial pressure (-17%), pulmonary artery pressure (-20%), wedge pressure (-30%), aortic pressure (-49%), cardiac output (-33%), distal IMA pressure (-54%), and IMA flow (-85%). During hypovolemia, IMA flow could not be increased with topical application of papaverine, but baseline values were achieved after retransfusion of the withdrawn blood volume. Gradual hypovolemia and application of large doses of nitrates showed less dramatic effects, and injection of an epinephrine bolus under normovolemic conditions increased aortic pressure and IMA flow. Under sever hypovolemia, however, administration of an epinephrine bolus provoked only a minimal increase in aortic pressure and a contrasting decrease in IMA flow. We conclude that sudden, severe hypovolemia can lead to disproportionate IMA flow reduction and that pharmacological interventions are delicate under these circumstances.
authors.affiliation: Clinic for Cardiovascular Surgery, University Hospital, Zürich, Switzerland.
authors.forename: L K
authors.initials: LK
authors.lastname: von Segesser
authors.forename: K
authors.initials: K
authors.lastname: Lehmann
authors.forename: M
authors.initials: M
authors.lastname: Turina
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007387:Internal Mammary-Coronary Artery Anastomosis; D009566:Nitrates / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D011183:Postoperative Complications / Q000209:etiology*; D011673:Pulsatile Flow / Q000187:drug effects; D012769:Shock / Q000150:complications*
chemical_list: D009566:Nitrates; D010208:Papaverine; D004837:Epinephrine