Cellulose sulfate increases blood concentration of kinins in rats.
Intravenous injection of cellulose sulfate (CS) in rats induced a dose-dependent decrease of blood pressure accompanied by a concomitant increase of circulating levels of immunoreactive bradykinin (BK) from a level of 52 pg/mL of blood in control animals to 400 pg/mL in the group injected with 3.0 mg/kg of CS. An increase of desArg9BK was also observed while the blood concentration of BK(1-7) remained constant. Kinins contents in acidic extracts of lungs increased slightly while renal kinins from the same animals showed a slight decrease. The results suggest that plasma kallikrein-kinin system mediates CS-induced hypotension and that glandular kallikreins do not participate to the hypotensive action of CS.
Barabé
J
J
Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Québec, Canada.
Huberdeau
D
D
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002482:Cellulose / Q000031:analogs & derivatives* / Q000494:pharmacology; D007610:Kallikreins / Q000097:blood; D007668:Kidney / Q000378:metabolism; D007705:Kinins / Q000097:blood*; D008168:Lung / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007705:Kinins; D002482:Cellulose; C020254:cellulose sulfate; D007610:Kallikreins