title: [L-DOPA interaction with the brain tissue DNA of rats].
abstract: The possibility of direct interaction of L-DOPA with DNA isolated from rat brain tissue has been considered. The spectral and viscosity data suggest conformational changes in L-DOPA-treated DNA in conditions excluding the accumulation of L-DOPA oxidation products.
authors.forename: T M
authors.initials: TM
authors.lastname: Tret'iak
authors.forename: V N
authors.initials: VN
authors.lastname: Biriukov
authors.forename: T I
authors.initials: TI
authors.lastname: Smol'ianinova
mesh_terms: D000818:Animals; D001483:Base Sequence / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004247:DNA / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D066298:In Vitro Techniques; D007980:Levodopa / Q000378:metabolism / Q000494:pharmacology*; D008970:Molecular Weight; D009690:Nucleic Acid Conformation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007980:Levodopa; D004247:DNA
vernacular_title: Vzaimodeĭstvie L-DOFA s DNK tkani goloovnogo mozga krys.