title: A fast and sensitive multiple sequence alignment algorithm.
abstract: A two-step multiple alignment strategy is presented that allows rapid alignment of a set of homologous sequences and comparison of pre-aligned groups of sequences. Examples are given demonstrating the improvement in the quality of alignments when comparing entire groups instead of single sequences. The modular design of computer programs based on this algorithm allows for storage of aligned sequences and successive alignment of any number of sequences.
authors.affiliation: European Molecular Biology Laboratory, Heidelberg, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Vingron
authors.forename: P
authors.initials: P
authors.lastname: Argos
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D000818:Animals; D001400:Azurin; D006454:Hemoglobins; D006801:Humans; D008969:Molecular Sequence Data; D010970:Plastocyanin; D011487:Protein Conformation; D012697:Serine Endopeptidases; D012984:Software
chemical_list: D006454:Hemoglobins; D001400:Azurin; D010970:Plastocyanin; D012697:Serine Endopeptidases