The ototoxic effect of cisplatin on guinea pigs in relation to dosage.
The effect on the electrophysiological hearing thresholds and the endocochlear DC potential (EP) was studied in four groups of guinea pigs receiving different doses of cisplatin. By multiple low-dose intraperitoneal injections a permanent hearing loss was produced without a permanent decrease of the EP. On the other hand, when cisplatin was given as a single high-dose intravenous injection, there was an impairment of the electrophysiological hearing thresholds and EP, depending upon the level of cisplatin dose. It is concluded that cisplatin-induced hearing loss is not necessarily a sequela to a loss of EP.
Laurell
G
G
Institute of Physiology II, Karolinska Institute, Stockholm, Sweden.
Engström
B
B
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects*; D001933:Brain Stem / Q000187:drug effects; D002945:Cisplatin / Q000633:toxicity*; D003056:Cochlear Nerve / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects; D007274:Injections, Intraperitoneal
D002945:Cisplatin