[Effect of sodium depletion on the renin-angiotensin-aldosterone system and prostaglandins in patients with insulin-dependent diabetes mellitus].
The effects of 5 days sodium-free diet associated with furosemide administration were studied in 12 diabetic patients with insulin-dependent diabetes mellitus and 12 healthy control subjects. Plasma renin activity was significantly lower in diabetics compared with that of normal subjects. Plasma aldosterone was similar in both groups. Urinary excretion of prostaglandin E2 was significantly lower in diabetics before and after sodium depletion in comparison with normal subjects. Urinary excretion of 6-keto prostaglandin F1 alpha and thromboxane B2 was similar in both groups. It is concluded that the lower excretion of prostaglandin E2 in diabetics is related to the decreased activity of renin-angiotensin system. Decreased production of prostaglandin E2 may contribute to the development of arterial hypertension in the diabetes mellitus.
Koev
D
D
Institut d'endocrinologie et gérontologie, Académie de médecine, Sofia, Bulgarie.
Zachariéva
S
S
Andonova
K
K
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D004039:Diet, Sodium-Restricted / Q000009:adverse effects*; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000503:physiopathology; D008297:Male; D011453:Prostaglandins / Q000097:blood*; D012084:Renin-Angiotensin System / Q000187:drug effects*
D011453:Prostaglandins; D005665:Furosemide
Influence de la déplétion sodée sur le système rénine-angio-tensine-aldostérone et les prostaglandines chez des malades atteints de diabète sucré, insulino-dépendant.