The biodistribution of [75Se]bis-[beta-(N,N,N-trimethylamino)ethyl]selenide diiodide in adult guinea pigs.
The biodistribution of [75Se]BISTAES was studied in guinea pigs. A higher concentration of radioactivity was observed in articular cartilage than in other tissues or organs. A minimal amount of radioactivity was found in the blood, muscle and bone. The compound was excreted rapidly in urine. The target to background ratios were encouraging. [75Se]BISTAES has potential as an articular cartilage imaging agent and further studies in osteoarthritic animals are merited.
Yu
W K
WK
School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana.
Shaw
S M
SM
Bartlett
J M
JM
Van Sickle
D C
DC
Mock
B H
BH
D000818:Animals; D002358:Cartilage, Articular / Q000000981:diagnostic imaging* / Q000378:metabolism; D006168:Guinea Pigs; D010003:Osteoarthritis / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D012644:Selenium Radioisotopes / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D012644:Selenium Radioisotopes; C055707:bis(N,N,N-trimethylamino)ethylselenide-Se iodide