title: Ischemic heart disease as copper deficiency.
abstract: Atherosclerosis is a complex process beginning early in life and often leading to death from ischemic heart disease in middle age. Hundreds of factors are said to contribute to this risk. More than 50 similarities between animals deficient in copper and people with ischemic heart disease have been identified. Some of the more important characteristics of this illness have been produced in experiments in which men and women were fed diets low in copper. Diets with similarly low amounts of copper are readily available to the population at large. More aspects of the anatomy, biochemistry, chemistry, epidemiology, pathogenesis and pathophysiology of ischemic heart disease can be explained by considering this illness to be a problem of copper deficiency than by considering any of several other explanations that have been offered.
authors.affiliation: USDA, ARS, Grand Forks Human Nutrition Research Center, N.D.
authors.forename: L M
authors.initials: LM
authors.lastname: Klevay
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D003300:Copper / Q000172:deficiency*; D003327:Coronary Disease / Q000188:drug therapy / Q000378:metabolism*; D004032:Diet; D006801:Humans
chemical_list: D000924:Anticholesteremic Agents; D003300:Copper