In vitro modulation of lymphocyte proliferation by prednisolone and interferon-alpha in patients with HTLV-I-associated myelopathy (HAM).
One of the hallmarks of human T-lymphotropic virus type I (HTLV-I) infection is the proliferation in vitro of peripheral blood lymphocytes (PBLs) in the absence of growth factors. This phenomenon, the autologous proliferative response (APR), involves spontaneous growth of HTLV-I-infected T-cells and proliferation of T-cells in response to the infected cells. We studied the modulating effect of prednisolone (PSL) and interferon-alpha (IFN) on APR of PBLs obtained from five patients with HTLV-I-associated myelopathy (HAM). APR was significantly inhibited by PSL and IFN suggesting that APR is important in the pathogenesis of HAM.
Ijichi
S
S
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
Eiraku
N
N
Osame
M
M
Izumo
S
S
Kubota
R
R
Maruyama
I
I
Matsumoto
M
M
Sonoda
S
S
D000328:Adult; D000368:Aged; D002455:Cell Division / Q000187:drug effects; D005260:Female; D015490:HTLV-I Infections / Q000150:complications*; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D008214:Lymphocytes / Q000473:pathology*; D008875:Middle Aged; D011239:Prednisolone / Q000494:pharmacology*; D013118:Spinal Cord Diseases / Q000097:blood / Q000209:etiology* / Q000473:pathology
D007370:Interferon Type I; D011239:Prednisolone