The effect on the cornea of alpha cyclodextrin vehicle for cyclosporin eye drops.
We tested four different combinations of alpha-CD and CYA: 0.075% and 80 mg/mL alpha-CD, 0.025% CYA and 40 mg/mL alpha-CD, 0.009% CYA and 20 mg/mL alpha-CD, and 0.003% CYA and 10 mg/mL alpha-CD. We found that 0.025% CYA (alpha-CD[40 mg/mL]) resulted in the least corneal toxicity and penetrated in the cornea 5 to 10 times more than did lipophilic vehicle with CYA.
Kanai
A
A
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan.
Alba
R M
RM
Takano
T
T
Kobayashi
C
C
Nakajima
A
A
Kurihara
K
K
Yokoyama
T
T
Fukami
M
M
D000287:Administration, Topical; D000818:Animals; D003315:Cornea / Q000187:drug effects* / Q000648:ultrastructure; D003505:Cyclodextrins / Q000008:administration & dosage*; D003524:Cyclosporins / Q000008:administration & dosage*; D003912:Dextrins / Q000008:administration & dosage*; D008855:Microscopy, Electron, Scanning; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D011817:Rabbits; D051381:Rats; D013213:Starch / Q000008:administration & dosage*; D047391:alpha-Cyclodextrins
D003505:Cyclodextrins; D003524:Cyclosporins; D003912:Dextrins; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D047391:alpha-Cyclodextrins; D013213:Starch; C032613:alpha-cyclodextrin