[Assay of fructosamine. Value and limits in diabetology].
Fructosamine test using a Nitroblue Tetrazolium (NBT) method offers many advantages: quickness, reproducibility, easy automation and unexpansiveness, but a standardization of the different methods is needed. The results can be expressed in absolute value of equivalent DMF per liter, except in pregnancy where mumol per g of protein is used. The interpretation of the results can be difficult in case of quantitative and/or qualitative proteins abnormalities: icterus and severe chronic renal insufficiency. Fructosamine is significantly higher in diabetic patients. It gives a good correlation with glycated haemoglobin but the provided information is different, concerning a shorter period of 2 to 3 weeks and perhaps more sensitive to recent glycaemic variations. Fructosamine test does not seem to be a good screening test for diabetes and impaired glucose tolerance. The test indications of the assay could be: situations where the dosage of glycated haemoglobin is not interpretable, diabetic pregnancy follow-up and short term evaluation of a therapeutic change on glycaemic control. However, the individual significance of fructosamine concentration remains to be assessed and seems to be less accurate than glycated albumin.
Leutenegger
M
M
Clinique Médicale, Hôpital Robert-Debré, Reims.
Gillery
P
P
Gross
A
A
Pasqual
C
C
Ostermann
G
G
Durlach
V
V
D001681:Biological Assay / Q000379:methods; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D019270:Fructosamine; D006442:Glycated Hemoglobin / Q000032:analysis; D006595:Hexosamines / Q000097:blood*; D006801:Humans; D009580:Nitroblue Tetrazolium; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood
D019270:Fructosamine; D006442:Glycated Hemoglobin; D006595:Hexosamines; D009580:Nitroblue Tetrazolium
Dosage de la fructosamine. Intérêt et limites en diabétologie.