Urinary excretion of pentoxifylline and its metabolites by standardbred mares.
The urinary excretion of a sustained-release formulation of pentoxifylline was studied in the horse after the oral administration of 4.0 grams of Trental tablets. Urine samples were collected for 24 hours after dosing and analyzed for pentoxifylline and its metabolites using high-performance liquid chromatography coupled with an ultraviolet detector. Six metabolites of pentoxifylline were identified in horse urine in addition to less than 0.2% of unchanged drug. Concomitant use of gas chromatography/mass spectrometry allowed for the elucidation of the chemical structures of the metabolites. Metabolism of pentoxifylline yields one demethylated derivative, four hydroxylated metabolites and a conjugate of one of the hydroxymetabolites as urine products. The demethylated derivative, 3-methyl-1-(5-oxohexyl)-xanthine, was found to be the predominant metabolite in the urine.
Kwong
E C
EC
CanTest Ltd., Vancouver, British Columbia.
Chen
F C
FC
Young
L M
LM
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D005260:Female; D006736:Horses / Q000652:urine*; D010431:Pentoxifylline / Q000031:analogs & derivatives / Q000378:metabolism / Q000493:pharmacokinetics / Q000652:urine*; D013805:Theobromine / Q000031:analogs & derivatives*; D013997:Time Factors
D003692:Delayed-Action Preparations; D013805:Theobromine; D010431:Pentoxifylline