title: ChlVPP chemotherapy in advanced Hodgkin's disease.
abstract: Between March 1978 and January 1987 54 patients with advanced Hodgkin's disease (HD) or relapse following radiotherapy (RT) for Hodgkin's disease have been treated with combination chemotherapy consisting of chlorambucil, vinblastine, procarbazine and prednisolone (ChlVPP). A subgroup of five patients with bulky mediastinal disease received mantle RT in addition to ChlVPP chemotherapy. Forty-two patients (77.8%) entered complete remission with 33 (61.0%) remaining in unmaintained remission and 44 (81.5%) alive at a median follow up of 51 months (range: 22-103). The treatment was generally well tolerated with minimal toxicity. ChlVPP is effective first-line treatment for Hodgkin's disease with results which may be comparable to those achieved for MOPP but with significantly less toxicity.
authors.affiliation: CRC Wessex Regional Medical Oncology Unit, University of Southampton, Hants, U.K.
authors.forename: J J
authors.initials: JJ
authors.lastname: McKendrick
authors.forename: G M
authors.initials: GM
authors.lastname: Mead
authors.forename: J
authors.initials: J
authors.lastname: Sweetenham
authors.forename: D H
authors.initials: DH
authors.lastname: Jones
authors.forename: C J
authors.initials: CJ
authors.lastname: Williams
authors.forename: R
authors.initials: R
authors.lastname: Ryall
authors.forename: J M
authors.initials: JM
authors.lastname: Whitehouse
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002699:Chlorambucil / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D011344:Procarbazine / Q000008:administration & dosage / Q000009:adverse effects; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D002699:Chlorambucil; D011344:Procarbazine; D014747:Vinblastine; D011239:Prednisolone