Increased concentrations of liver cholesterol in rats fed lactulose.
The disaccharide lactulose (beta-D-galactopyranosyl-(1-4)-D-fructofuranose) is thought to be poorly hydrolized by intestinal enzymes but is broken down by microorganisms in the colon. Thus lactulose shares with pectin similar characteristics. Lactulose is used in the food industry and in the treatment of constipation. There is preliminary evidence that dietary lactulose (5%, w/w) causes increased concentrations of serum and liver cholesterol in rats when compared with pectin. This paper describes dose-response relationships between dietary lactulose and cholesterol in either serum or liver.
Beynen
A C
AC
Department of Laboratory Animal Science, State University, Utrecht, The Netherlands.
D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D004032:Diet; D004187:Disaccharides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007792:Lactulose / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004187:Disaccharides; D007792:Lactulose; D002784:Cholesterol