Bioavailability of citrate from two different preparations of potassium citrate.
The bioavailability of citrate from two different preparations of potassium citrate was examined in eighteen normal volunteers during three phases of study. After stabilization on a constant metabolic diet, subjects took a single dose of placebo, "slow-release" potassium citrate tablets (60 meq) or rapid-release liquid potassium citrate preparation (60 meq). Timed urine specimens were collected for 24 hours and analyzed for citrate, potassium, and pH. Similar biochemical findings were observed following administration of the two different preparations with the onset and decline of changes being slightly more rapid for the liquid potassium citrate than the tablet preparation. These equivalent bioavailability data indicate that the liquid preparation is a comparable therapeutic alternative to the tablet form.
Harvey
J A
JA
Center in Mineral Metabolism and Clinical Research, UT Southwestern Medical Center, Dallas 75235.
Zobitz
M M
MM
Pak
C Y
CY
D000328:Adult; D001682:Biological Availability; D002951:Citrates / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D019343:Citric Acid; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000652:urine; D013997:Time Factors
D002951:Citrates; D019343:Citric Acid; D011188:Potassium