title: Low molecular weight immunosuppressors secreted by adult Nematospiroides dubius.
abstract: Adult Nematospiroides dubius excretory-secretory products (ES) were collected from worms cultured in vitro, separated by sodium dodecyl sulphate--polyacrylamide gel electrophoresis (SDS-PAGE) into four fractions (FI-IV), electroeluted and assessed for their ability to inhibit the proliferation of mouse lymphocytes stimulated by mitogens in vitro. The proliferation of mitogen- and ES-stimulated mouse spleen lymphocytes from normal and infected mice was inhibited by low mol. wt ES F-IV (less than 26,000).
authors.forename: F G
authors.initials: FG
authors.lastname: Monroy
authors.forename: C
authors.initials: C
authors.lastname: Dobson
authors.forename: J H
authors.initials: JH
authors.lastname: Adams
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D005260:Female; D006369:Heligmosomatoidea / Q000276:immunology*; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D009351:Nematospiroides dubius / Q000276:immunology*
chemical_list: D000947:Antigens, Helminth