Phosphosugars are potent inhibitors of central nervous system inflammation.
Adoptively transferred allergic encephalomyelitis can be inhibited by various phosphosugars, particularly mannose-6-phosphate. The sugar specificity suggests that inhibition may be due to depletion of lymphocyte cell-surface lysosomal enzymes, which are essential for the passage of lymphocytes across the vascular endothelium and the entry of lymphocytes into the central nervous system parenchyma.
Willenborg
D O
DO
Division of Virology and Cellular Pathology, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T.
Parish
C R
CR
Cowden
W B
WB
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006600:Hexosephosphates / Q000627:therapeutic use*; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000201:enzymology / Q000276:immunology; D008297:Male; D008360:Mannosephosphates / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats
D006600:Hexosephosphates; D008360:Mannosephosphates; C027693:mannose-6-phosphate