Binucleate cells in the Ehrlich ascites tumor. Autoradiographic labeling.
An autoradiographic study was performed on binucleate and mitotic cells in the Ehrlich ascites tumor (EAT) untreated and after treatment with 5-fluorouracil (FU). The number of binucleate cells was greater in the treated tumor than in the controls. It was also observed that the number of labeled mitoses was greater in the Fu-treated tumor. Autoradiographic labeling showed that the cells that proved to be binucleate had previously passed through S-phase; thus, these cells belonged to the proliferative compartment.
Pertusa
J
J
Departamento de Biologia Animal y Celular, Genetica y Parasitologia, Universitat de Valencia, Spain.
Pellicer
J A
JA
Alcober
V
V
D000818:Animals; D001345:Autoradiography; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology / Q000648:ultrastructure*; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D008940:Mitotic Index; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D014316:Tritium; D005472:Fluorouracil; D013936:Thymidine