Lipopolysaccharide-stimulated rat brain macrophages release NGF in vitro.
Amoeboid microglial cells purified from primary cultures of embryonic rat brains and stimulated with bacterial lipopolysaccharides released high amounts of nerve growth factor. This finding suggests that brain macrophages play a major neurotrophic role during development, in adulthood, and in the regenerative events that follow localized lesions.
Mallat
M
M
INSERUM U114, Collège de France, Paris.
Houlgatte
R
R
Brachet
P
P
Prochiantz
A
A
D000818:Animals; D001921:Brain / Q000166:cytology*; D002452:Cell Count; D002460:Cell Line; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000378:metabolism*; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats
D008070:Lipopolysaccharides; D009414:Nerve Growth Factors