title: An open label trial of the possible analgesic effects of dipyridamole.
abstract: There is experimental evidence that adenosine and the adenosinergic agent dipyridamole may inhibit the activity of nociceptive neurons. Dipyridamole was given to 15 patients with chronic pain in an open uncontrolled investigation. Eleven patients tolerated the drug well and seven of these patients obtained subjective benefit. The results are held to justify further investigation under controlled blind conditions. A possible ceiling effect of dipyridamole was noted.
authors.forename: H
authors.initials: H
authors.lastname: Merskey
authors.forename: J T
authors.initials: JT
authors.lastname: Hamilton
mesh_terms: D000328:Adult; D000700:Analgesics; D002908:Chronic Disease; D004176:Dipyridamole / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*
chemical_list: D000700:Analgesics; D004176:Dipyridamole