Defibrotide decreases cholesterol amount in hypercholesterolemic rabbit aorta, with no modification of plasma or lipoprotein cholesterol.
Defibrotide, (D) an antithrombotic agent, when administered i.v. to cholesterol-fed rabbits decreased cholesterol in the aorta without changing total plasma cholesterol, triglyceride or phospholipid, nor the cholesterol, triglyceride, phospholipid and protein of plasma lipoproteins. Platelet aggregation was decreased in rabbits treated with D. There were fewer vascular lesions in the hearts and kidneys of animals treated with D than in animals fed cholesterol and treated with placebo. These data suggest that the antithrombotic activity of D and its ability to reduce platelet sensitivity could help to reduce the amount of cholesterol in the cardiovascular system in atherosclerosis-prone situations.
Pescador
R
R
Crinos Biological Research Laboratories, Villa Guardia Como, Italy.
Porta
R
R
Conz
A
A
Mantovani
M
M
Prino
G
G
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D003331:Coronary Vessels / Q000473:pathology; D005343:Fibrinolytic Agents; D006937:Hypercholesterolemia / Q000378:metabolism* / Q000473:pathology; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D010743:Phospholipids / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects; D011089:Polydeoxyribonucleotides / Q000494:pharmacology*; D011817:Rabbits; D012077:Renal Artery / Q000473:pathology; D014280:Triglycerides / Q000097:blood
D005343:Fibrinolytic Agents; D008074:Lipoproteins; D010743:Phospholipids; D011089:Polydeoxyribonucleotides; D014280:Triglycerides; C036901:defibrotide; D000244:Adenosine Diphosphate; D002784:Cholesterol