title: Effect of fenbendazole and pyrantel tartrate on the induction of protective immunity in pigs naturally or experimentally infected with Ascaris suum.
abstract: An experiment was conducted with 96 weanling pigs (avg initial wt 18.5 kg) divided into six treatment with two replicates of eight pigs each. Pigs in Treatments 1, 2 and 3 were penned in outside pens with dirt lots that previously were contaminated with A. suum ova to induce a natural ascaris infection. Pigs in Treatments 4, 5 and 6 were penned in an open-front building with solid concrete floors and were experimentally infected with 2,000 embryonated A. suum. ova on d 1, 15 and 29 of the experiment. Pigs in Treatments 1 and 4 were medicated with fenbendazole (FBZ, 3 mg/[kg BW.d]) for three consecutive days during three consecutive time periods. Pigs in Treatments 2 and 5 were medicated with pyrantel tartrate (PT, 106 mg/kg feed) for 28 d. Pigs in Treatments 3 and 6 served as infected, unmedicated controls. All pigs were challenged with 100 A. suum eggs 7 d after termination of the final FBZ treatment. All pigs were killed 66 d after challenge and worms were recovered. Fenbendazole treatment resulted in greater (P less than .07) average daily gain than PT treatment in pigs penned outside. Among inside pigs, FBZ treatment resulted in better (P less than .02) feed utilization than in controls. The FBZ and PT treatments reduced (P less than .03) the total number of A. suum, the length and weight of female ascarids and the length of male ascarids compared with controls. A natural continual infection with A. suum was less effective than experimental infection in inducing protective immunity in pigs.
authors.affiliation: Louisiana State University Agricultural Center, Baton Rouge.
authors.forename: L L
authors.initials: LL
authors.lastname: Southern
authors.forename: T B
authors.initials: TB
authors.lastname: Stewart
authors.forename: E
authors.initials: E
authors.lastname: Bodak-Koszalka
authors.forename: D L
authors.initials: DL
authors.lastname: Leon
authors.forename: P G
authors.initials: PG
authors.lastname: Hoyt
authors.forename: M E
authors.initials: ME
authors.lastname: Bessette
mesh_terms: D000818:Animals; D001196:Ascariasis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D001562:Benzimidazoles / Q000627:therapeutic use*; D005260:Female; D005273:Fenbendazole / Q000627:therapeutic use*; D006799:Housing, Animal; D008099:Liver / Q000254:growth & development; D008168:Lung / Q000254:growth & development; D008297:Male; D009929:Organ Size; D010270:Parasite Egg Count / Q000662:veterinary; D011715:Pyrantel / Q000031:analogs & derivatives*; D011717:Pyrantel Tartrate / Q000627:therapeutic use*; D011897:Random Allocation; D013552:Swine; D013553:Swine Diseases / Q000276:immunology* / Q000517:prevention & control; D015430:Weight Gain
chemical_list: D001562:Benzimidazoles; D011715:Pyrantel; D005273:Fenbendazole; D011717:Pyrantel Tartrate