Oral clonidine: an effective growth hormone provocative test.
Twenty normal statured healthy children (8 M; 12 F) aged 9-16 years were subjected to growth hormone (GH) provocative tests. The mean basal GH level was 2.0 +/- 0.42 ng/ml (+/- SEM). The mean peak levels of GH were 11.9 +/- 2.19 ng/ml (+/- SEM) after exercise, 9.82 +/- 2.81 ng/ml (+/- SEM) after insulin and 15.2 +/- 2.54 ng/ml (+/- SEM) after oral clonidine. A significant rise (peak level greater than 7 ng/ml) of serum GH was found in 70, 80 and 85% of children after exercise, insulin and oral clonidine tests, respectively. The observation in the present study indicates that oral clonidine test, a safer, easier and more economical test than insulin hypoglycemia, is equally potent and can be done in out patients.
Singh
S K
SK
Hatwal
A
A
Agrawal
J K
JK
Bajpai
H S
HS
Singh
S K
SK
D000284:Administration, Oral; D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D003000:Clonidine / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D008297:Male; D005082:Physical Exertion
D001786:Blood Glucose; D007328:Insulin; D013006:Growth Hormone; D003000:Clonidine