Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells.
Only a few of the genes involved in DNA repair in mammalian cells have been isolated, and induction of a DNA repair gene in response to DNA damage has not yet been established. DNA polymerase beta (beta-polymerase) appears to have a synthetic role in DNA repair after certain types of DNA damage. Here we show that the level of beta-polymerase mRNA is increased in CHO cells after treatment with several DNA-damaging agents.
Fornace
A J
AJ
Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892.
Zmudzka
B
B
Hollander
M C
MC
Wilson
S H
SH
D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004249:DNA Damage; D004256:DNA Polymerase I / Q000096:biosynthesis / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects / Q000528:radiation effects; D008741:Methyl Methanesulfonate; D008769:Methylnitronitrosoguanidine; D010053:Ovary; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics*; D014466:Ultraviolet Rays
D012333:RNA, Messenger; D008769:Methylnitronitrosoguanidine; D008741:Methyl Methanesulfonate; D004256:DNA Polymerase I