Gastroesophageal dysfunction in Cornelia de Lange syndrome.
Children with Cornelia de Lange (CDL) syndrome present with feeding problems related to swallowing incoordination, poor esophageal motility, and gastroesophageal reflux (GER). These abnormalities of esophageal function result in failure to thrive and life-threatening aspiration pneumonia. Severe GER was documented in four patients with CDL syndrome. Three were managed successfully with an antireflux procedure (Nissen fundoplication) and a concomitant feeding gastrostomy. These observations confirm the high incidence of abnormal esophageal function in patients with CDL syndrome, and suggest that an antireflux procedure and feeding gastrostomy are important considerations in their clinical management.
Cates
M
M
Department of Surgery, Indiana University School of Medicine, Indianapolis.
Billmire
D F
DF
Bull
M J
MJ
Grosfeld
J L
JL
D002675:Child, Preschool; D003635:De Lange Syndrome / Q000000981:diagnostic imaging / Q000601:surgery*; D004943:Esophagogastric Junction / Q000601:surgery; D005260:Female; D005764:Gastroesophageal Reflux / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011859:Radiography; D013348:Subclavian Artery / Q000002:abnormalities