[A new stage in the development of the membrane concept of the pathogenesis of primary hypertension: the role of cellular oncogenes in the genesis of membrane disorders].
The membrane concept of the primary (essential) hypertension pathogenesis considers the start of the disease as being linked to the characteristic disturbances of the cation-transport function. The membrane alteration result in the increase of the free calcium ion concentration in the cell cytoplasm and are the cause of both the contractile properties alteration of the vascular smooth muscle cells and the alteration of the neuromediator release in the nerve endings. The further stage in the evolution of this concept was the observation of the pathogenetic ling between the membrane "defect" in the primary hypertension and the alteration of the cell oncogenes (proto-oncogenes) function. The presence of such a link may be confirmed by both the indirect proofs considered in the paper and the results of the DNA study in rats with a spontaneous hypertension by method of RFLP analysis.
Postnov
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D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002118:Calcium / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology*; D004910:Erythrocyte Membrane / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D009857:Oncogenes / Q000235:genetics / Q000502:physiology; D010716:Phosphatidylinositols / Q000502:physiology; D011519:Proto-Oncogenes / Q000235:genetics / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013315:Stress, Psychological / Q000150:complications
D010716:Phosphatidylinositols; D002118:Calcium
O novom étape v razvitii membrannoĭ kontseptsii patogeneza pervichnoĭ gipertenzii: rol' kletochnykh onkogenov v geneze membrannykh narusheniĭ.