Dendritic cell ontogeny.
Abundant evidence indicates that dendritic cells arise from the bone marrow. In vitro, precursors that differ phenotypically from mature dendritic cells divide several times to form functional dendritic cells. A soluble factor(s) produced in the supernatants of ConA-stimulated spleen cells enhances the production of dendritic cells. This factor(s) has not been fully characterized. Further maturation of dendritic cells occurs after they are released from the bone marrow; species differences exist. Interrelationships between various types of dendritic cells need to be elucidated.
Bowers
W E
WE
Medical Research Institute, Mary Imogene Bassett Hospital, Cooperstown, New York 13326.
Goodell
E M
EM
D000818:Animals; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology