[The trial use of alpha-IFN in treating a case of chronic myelomonocytic leukemia with splenic infarction].
A 75-year-old man, previously diagnosed as having chronic myelomonocytic leukemia, suffered an attack of severe left hypochondralgia in July 1986. A splenic infarction was diagnosed by both ultrasound tomography and computerized tomography. The patient was treated with alpha-Interferon (600 M.U./day i.m.) for cytoreduction in order to prevent a recurrence of the splenic infarction. Twenty-one days later, the peripheral white blood cell count decreased from 44,110 microliters to 9800/microliters and the monocytoid immature cells disappeared. However, severe dementia appeared and so alpha-Interferon therapy was abandoned. In this report the beneficial effects and side effects of alpha-interferon in the treatment of chronic myelomonocytic leukemia are discussed.
Kimura
S
S
1st Dept. of Int. Med., Kyoto Prefectural Univ. of Med.
Yokoo
K
K
Ozawa
M
M
Kobayashi
Y
Y
Horiuchi
H
H
Kondo
M
M
D000368:Aged; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D015477:Leukemia, Myelomonocytic, Chronic / Q000097:blood / Q000150:complications / Q000628:therapy*; D007958:Leukocyte Count; D007964:Leukocytosis / Q000097:blood / Q000150:complications / Q000628:therapy; D008297:Male; D012008:Recurrence; D013159:Splenic Infarction / Q000097:blood / Q000209:etiology* / Q000517:prevention & control
D007370:Interferon Type I