Use of caffeine in the treatment of apnea associated with the Arnold-Chiari malformation.
The occurrence of significant apnea has been reported in infants with Arnold-Chiari malformation (ACM). We report 1 infant with ACM and severe apnea treated with caffeine therapy. There was a marked decrease in apnea frequency, less variability in breathing patterns, and a shift to the left of the CO2 response curve with caffeine. Our findings in 1 infant suggest that caffeine may be an effective adjunct in the treatment of apnea associated with ACM.
Davis
J M
JM
Developmental Pharmacology and Perinatal Research Unit, Montreal Children's Hospital Research Institute, Que., Canada.
Zinman
R
R
Aranda
J V
JV
D001139:Arnold-Chiari Malformation / Q000150:complications*; D002110:Caffeine / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012891:Sleep Apnea Syndromes / Q000188:drug therapy* / Q000209:etiology
D002110:Caffeine