title: [The significance of thrombolytic therapy in acute myocardial infarct in advanced age].
abstract: The thromboticgenesis and the close time dependence of the development of the acute myocardial infarction (AMI) are decisive findings of the dynamic development in the past ten years. Therapy started in time including the elimination of the thrombotic coronary occlusion as soon as possible leads to the reperfusion of the vessel affected by the infarction and thus to the limitation of the size of the myocardial infarction. Because of the temporally limited tolerance of ischaemia of the myocardium, an efficient thrombolytic therapy (TT) with an objectifiable improvement of the left-ventricular function (ejection fraction global-EFg) is possible up to the 4th ApS hour. The median value of the maximum creatine kinase activity (CKmax) time was 11.8 h with effective TT; with ineffective TT 21.5 h (p less than 0.001). There is no significant difference of the CKmax-t between the age groups (less than 60 and greater than 60 years). CKmax significantly differentiates between the deceased and ineffective/effective TT (p less than 0.001). Monitoring the EFg shows significant differences in the deceased (16.3), ineffective TT (34.0), and effective TT (42.5%) both in the acute phase and in the first weeks after AMI by the dynamism of the EFg. So, - EFg was verified to be 6% with effective TT to - EFg to be 1.6% (absolute) with ineffective TT. The percentage of cases of death was restricted also for patients greater than 60 years. After effective TT less patients are found in the high and medium risk group after AMI. 70% of the patients had an effective TT.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Universitätsklinik für Innere Medizin, Bereiches Medizin (Charité) der Humboldt-Universität zu Berlin.
authors.forename: K
authors.initials: K
authors.lastname: Kothe
authors.forename: B
authors.initials: B
authors.lastname: Porstmann
authors.forename: R
authors.initials: R
authors.lastname: Aurisch
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003402:Creatine Kinase / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D015716:Electrocardiography, Ambulatory / Q000187:drug effects; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D011446:Prospective Studies; D013300:Streptokinase / Q000008:administration & dosage*; D013318:Stroke Volume / Q000187:drug effects*
chemical_list: D003402:Creatine Kinase; D013300:Streptokinase
vernacular_title: Bedeutung der Thrombolyse-Therapie beim akuten Myokardinfarkt im höheren Lebensalter.