Methazolamide-associated temporary leukopenia and thrombocytopenia.
A three-week course of methazolamide therapy for chronic open-angle glaucoma resulted in marked leukopenia and thrombocytopenia. Prompt discontinuation of therapy resulted in complete recovery of white blood cell and platelet counts within five days. The recommendations for patients receiving carbonic anhydrase inhibitors for blood count control at six-month intervals are discussed.
Cohen
A M
AM
Department of Medicine B, Sackler Medical School, Tel Aviv University, Israel.
Prialnik
M
M
Ben-Nissan
D S
DS
Savir
H
H
D000368:Aged; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced* / Q000150:complications; D008297:Male; D008704:Methazolamide / Q000009:adverse effects*; D013830:Thiadiazoles / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications; D013997:Time Factors
D013830:Thiadiazoles; D008704:Methazolamide