title: Effect of some novel synthetic analogues of CCK-4 on insulin and glucagon secretion.
abstract: The biologic activities of three synthetic analogues of CCK-4 (Trp-Met-Asp-Phe-NH2) in which (i) the C-terminal residue Phe was N-methylated (peptide I); (ii) the C-terminal Phe residue was N-methylated and Ser is substituted for Met in position 2 (peptide II); (iii) Pro was substituted for Trp in position 1 and the C-terminal amino nitrogen was methylated (peptide III), have been described. Peptides I and II have been found to inhibit the release of both insulin and glucagon, while peptide III was found to be a potent releasing agent for insulin and an inhibitor for glucagon.
authors.affiliation: Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: P
authors.initials: P
authors.lastname: Khalid
authors.forename: S
authors.initials: S
authors.lastname: Chaturvedi
authors.forename: M M
authors.initials: MM
authors.lastname: Khan
authors.forename: A K
authors.initials: AK
authors.lastname: Rastogi
authors.forename: B
authors.initials: B
authors.lastname: Kundu
authors.forename: F
authors.initials: F
authors.lastname: Ahmad
authors.forename: K B
authors.initials: KB
authors.lastname: Mathur
authors.forename: J R
authors.initials: JR
authors.lastname: Kidwai
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005755:Gastrins / Q000494:pharmacology*; D005934:Glucagon / Q000378:metabolism*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008969:Molecular Sequence Data; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship; D013758:Tetragastrin / Q000494:pharmacology*
chemical_list: D005755:Gastrins; D007328:Insulin; D013758:Tetragastrin; D005934:Glucagon