title: In vivo uptake and retention of fluoride after a brief application of TiF4 to dentin.
abstract: The purpose of this study was to examine the long-term retention of F and Ti in dentin after a brief application of 1% TiF4. Six facets of exposed dentin in each of four beagle dogs were treated for 10 sec or 1 min with a 1% solution of TiF4. Four control facets in a fifth dog were left untreated and extracted after 12 weeks. The TiF4-treated teeth were harvested after 4, 8, and 22 weeks and analyzed for F and Ti with an electron microprobe. The F concentrations in dentin surfaces of specimens retained in the mouth for 4, 8, and 22 weeks were after the 10-sec treatment 0.48% +/- 0.24, 0.51% +/- 0.20, and 0.56% +/- 0.20, respectively, and after the 1-min treatment 0.64% +/- 0.20, 0.66% +/- 0.18, and 0.71% +/- 0.19. High concentrations of Ti were found at the specimen surfaces in all groups. None of the control specimens showed F or Ti contents above the detection limits for the method used. The results showed that a very brief application of 1% TiF4 deposited high concentrations of F and Ti which were retained for at least 22 weeks.
authors.affiliation: Department of Dental Research School of Dentistry, University of Bergen, Norway.
authors.forename: L
authors.initials: L
authors.lastname: Skartveit
authors.forename: A B
authors.initials: AB
authors.lastname: Tveit
authors.forename: B
authors.initials: B
authors.lastname: Klinge
authors.forename: B
authors.initials: B
authors.lastname: Tøtdal
authors.forename: K A
authors.initials: KA
authors.lastname: Selvig
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002118:Calcium / Q000032:analysis; D003804:Dentin / Q000378:metabolism*; D004285:Dogs; D004577:Electron Probe Microanalysis; D005459:Fluorides / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics*; D013997:Time Factors; D014025:Titanium / Q000008:administration & dosage* / Q000032:analysis
chemical_list: D014025:Titanium; D005459:Fluorides; D002118:Calcium; C032240:titanium tetrafluoride