Immunoreactive thyroglobulin in sera and saliva of patients with various thyroid disorders: role of autoantibodies.
The present study was designed to assess the transfer of thyroglobulin (Tg) and anti-Tg antibodies (TgAb) to saliva in subjects with positive TgAb in their sera. Group I consisted of normal euthyroid control subjects (n = 10). Group II were patients with various thyroid disorders and no TgAb in their sera (n = 6). Group III were patients with thyroid disorders and TgAb in their sera (n = 31). The mean serum Tg level (+/- SE) and mean TgAb level [mean % binding +/- SE (range)] were as follows: Group I, Tg: 22.0 ng/ml +/- 1.64 (n = 10); TgAb 1.91% +/- 0.34 (range 0.6% to 4%). Group II, Tg: 119.8 ng/ml +/- 28.0 (n = 6) TgAb 1.59% +/- 0.34 (0.64% to 2.7%). Group III Tg 167.9 ng/ml +/- 41.0 (n = 31) TgAb 23.2% +/- 3.87 (4.2% to 67.5%). The mean salivary Tg level (SaTg) and mean TgAb binding (% +/- SE range) in saliva were as follows: Group I SaTg 2.07 ng/ml +/- 0.39 (n = 10) SaTgAb 1.13% +/- 0.38 (0% to 3.1). Group II SaTg 3.41 ng/ml +/- 0.67 (n = 6), SaTgAb 0.55% +/- 0.29 (0-1.9%). Group III SaTg 5.22 ng/ml +/- 0.96 (n = 31), SaTgAb 3.1% +/- 1.58 (0 to 47.7%). Salivary TgAb were only present in 4 out of 31 cases of Group III. Mean serum Tg in group IV-A was 75.01 ng/ml +/- 52.1 (n = 11). Mean serum TgAb in group IV-A was 1.94% +/- 0.31 (n = 11).(ABSTRACT TRUNCATED AT 250 WORDS)
Van Herle
A J
AJ
UCLA School of Medicine, Department of Medicine/Endocrinology 90024.
Rosenblit
P D
PD
Van Herle
T L
TL
Van Herle
P
P
Greipel
M
M
Kellett
K
K
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D011863:Radioimmunoassay; D012463:Saliva / Q000378:metabolism*; D013954:Thyroglobulin / Q000097:blood / Q000378:metabolism*; D013959:Thyroid Diseases / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology
D001323:Autoantibodies; D013954:Thyroglobulin