title: Contribution of hydroxyapatite to the tensile strength of the isobutyl-2-cyanoacrylate-bone bond.
abstract: The bonding strength between bone and alpha-2-cyanoacrylate polymers, with or without the addition of powdered hydroxyapatite, was determined. The tensile strength of a bone-cyanoacrylate bond was measured for each polymer: 4.31 +/- 0.88 MPa (methyl-), 5.74 +/- 0.62 MPa (ethyl-), and 8.33 +/- 0.41 MPa (isobutyl-). The tensile strength of the isobutyl-2-cyanoacrylate bond increased to 12.03 +/- 0.72 MPa with the addition of 10% (w/v) hydroxyapatite before decreasing to 7.89 +/- 0.58 MPa on addition of 15% (w/v) hydroxyapatite. An optimal concentration of hydroxyapatite significantly increased the tensile strength of a bone-cyanocacrylate bond in vitro in a manner comparable to reinforced bone replacement materials.
authors.affiliation: Department of Orthopaedics, University of Illinois, Chicago 60680.
authors.forename: F J
authors.initials: FJ
authors.lastname: Papatheofanis
mesh_terms: D000818:Animals; D001843:Bone Cements; D002015:Bucrylate; D003487:Cyanoacrylates; D006882:Hydroxyapatites; D066298:In Vitro Techniques; D008422:Materials Testing; D051381:Rats; D013718:Tensile Strength; D013977:Tibia
chemical_list: D001843:Bone Cements; D003487:Cyanoacrylates; D006882:Hydroxyapatites; D002015:Bucrylate