Pharmacokinetics of oxytetracycline in the turkey: evaluation of biliary and urinary excretion.
Oxytetracycline (OTC) pharmacokinetic values in plasma and bile were ascertained after IV administration of the drug. At 6 hours after administration of 1 mg of OTC/kg of body weight, 2.15% of the dose was found in the bile and 37.6% was found in the urine. At 2 hours after administration, the peak bile-to-plasma OTC concentration ratio was 60:1. Bioavailability of OTC was 47.6% when it was administered orally to fasted turkeys and was 9.4% when administered to fed turkeys.
Dyer
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Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Iowa State University, Ames 50011.
D000042:Absorption; D000818:Animals; D001646:Bile / Q000032:analysis*; D001682:Biological Availability; D008297:Male; D010118:Oxytetracycline / Q000493:pharmacokinetics* / Q000652:urine; D014422:Turkeys / Q000378:metabolism*
D010118:Oxytetracycline