[Respiratory depression following controlled-release morphine sulfate tablets].
Controlled release morphine sulfate (MS Contin) is a relatively new oral preparation for the relief of chronic severe (cancer) pain. We describe a patient with severe neuralgia who experienced respiratory depression after ingestion of one single dose of morphine sulfate (20 mg). Administration of nalorphine chloride resulted in instant normalisation of respiratory function. This case illustrates respiratory depression as an adverse effect of MS Contin.
Hoogslag
P A
PA
van Dijk
B
B
Vinks
A A
AA
D000368:Aged; D003692:Delayed-Action Preparations / Q000009:adverse effects; D005260:Female; D006801:Humans; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects*; D009269:Nalorphine / Q000627:therapeutic use; D009437:Neuralgia / Q000188:drug therapy; D012131:Respiratory Insufficiency / Q000139:chemically induced*
D003692:Delayed-Action Preparations; D009020:Morphine; D009269:Nalorphine
Ademhalingsdepressie na het gebruik van morfinesulfaat-tabletten met gereguleerde afgifte.