title: [Effectiveness of local delivery of ofloxacin using controlled-release strips (PT-01) in periodontal patients. Part 1. PT-01 application among treatment plans for periodontal disease].
abstract: Three different sites which have more than 5 mm pocket were randomly selected in each periodontal patient and were divided into three groups: PT-01 treated site, placebo treated site and control site. After application of either PT-01 or placebo twice for two weeks, subgingval scaling and root planing were performed. Then PT-01 and the placebo were applied weekly to the periodontal pocket for four weeks and clinical and microbiological evaluations were made. The results obtained were as follows: 1. On clinical evaluation, significant improvement was found in the PT-01 treated site in comparison with the placebo treated and/or control site. 2. On microbiological evaluation, slight improvement was found in the PT-01 treated site, whereas there was no significant difference among the three sites.
authors.forename: M
authors.initials: M
authors.lastname: Ueda
authors.forename: Y
authors.initials: Y
authors.lastname: Teranishi
authors.forename: T
authors.initials: T
authors.lastname: Kitamura
authors.forename: K
authors.initials: K
authors.lastname: Makigusa
authors.forename: T
authors.initials: T
authors.lastname: Shirai
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Higashi
authors.forename: S
authors.initials: S
authors.lastname: Ohashi
authors.forename: S
authors.initials: S
authors.lastname: Minamibayashi
authors.forename: A
authors.initials: A
authors.lastname: Yamaoka
mesh_terms: D003692:Delayed-Action Preparations; D012534:Dental Scaling; D006801:Humans; D015242:Ofloxacin / Q000008:administration & dosage*; D010510:Periodontal Diseases / Q000628:therapy*; D014092:Tooth Root / Q000601:surgery
chemical_list: D003692:Delayed-Action Preparations; D015242:Ofloxacin