title: Mechanisms of endogenous nitrosation.
abstract: Endogenous formation of N-nitroso compounds has been demonstrated in both humans and experimental animals. The extent of this process has been estimated by measurement of urinary N-nitrosoproline and has been shown to be modulated by dietary precursors and inhibitors. It is now also recognized that other (non-gastric) pathways of endogenous nitrosation, including those catalysed by bacteria and mammalian cells, may exist. The mammalian cell catalysed pathway utilizes arginine as a precursor for the nitrosating agent and may occur in macrophages or endothelial cells. The estimated contribution of this pathway to normal basal endogenous nitrosation is approximately 20 nmol of N-nitrosoproline/day.
authors.affiliation: Division of Toxicology, Massachusetts Institute of Technology, Cambridge 02139.
authors.forename: C D
authors.initials: CD
authors.lastname: Leaf
authors.forename: J S
authors.initials: JS
authors.lastname: Wishnok
authors.forename: S R
authors.initials: SR
authors.lastname: Tannenbaum
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism; D004727:Endothelium / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D015538:Nitrosation; D009603:Nitroso Compounds / Q000138:chemical synthesis / Q000378:metabolism*
chemical_list: D009603:Nitroso Compounds