Synergy of chymopapain and diatrizoate studied in an experimental model.
The effect of diatrizoate on the chronic toxicity of chymopapain in the epidural space was studied. Chymopapain was injected epidurally into four monkeys; chymopapain plus diatrizoate meglumine, into four. In 3 months, neither group developed significantly more arachnoiditis than a control group of animals that had received epidural injections of physiologic saline. No synergistic effect of chymopapain and diatrizoate on the meninges was detected.
Haughton
V M
VM
Department of Radiology, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee 53226.
Ho
K C
KC
Nguyen
C M
CM
D000818:Animals; D001100:Arachnoiditis / Q000139:chemically induced; D002917:Chymopapain / Q000633:toxicity*; D003974:Diatrizoate Meglumine / Q000633:toxicity*; D004357:Drug Synergism; D007268:Injections, Epidural; D008252:Macaca fascicularis; D008578:Meninges / Q000187:drug effects
D003974:Diatrizoate Meglumine; D002917:Chymopapain