Acute effects of low-dose cranial irradiation on regional capillary permeability in experimental brain tumors.
To determine the acute effects of low-dose cranial irradiation (CRT) on regional capillary permeability (RCP) of normal brain, brain tumor and damaged brain surrounding the tumor, we used quantitative autoradiography (QAR) to measure regional blood-to-tissue transport (K) of [14C]aminoisobutyric acid (AIB) in experimental C6 brain tumors 3-4 h after a single dose of 3 Gy CRT. K increased 63% in cortex, 30% in basal ganglia and 31% in brain surrounding the tumor (BST) vs. controls (P less than 0.005). K did not change in the tumor or in the brain adjacent to the tumor (BAT), suggesting that capillaries of normal parenchyma are more sensitive to the acute effects of CRT than capillaries of damaged parenchyma or tumor.
Delattre
J Y
JY
Cotzias Laboratory of Neuro-Oncology, Memorial Sloan-Kettering Cancer Center New York, NY 10021.
Shapiro
W R
WR
Posner
J B
JB
D000621:Aminoisobutyric Acids / Q000493:pharmacokinetics; D000818:Animals; D001932:Brain Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000532:radiotherapy*; D002199:Capillary Permeability / Q000528:radiation effects*; D002560:Cerebrovascular Circulation / Q000528:radiation effects*; D005910:Glioma / Q000098:blood supply / Q000378:metabolism / Q000532:radiotherapy*; D007091:Image Processing, Computer-Assisted; D008297:Male; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000532:radiotherapy*; D051381:Rats; D011919:Rats, Inbred Strains
D000621:Aminoisobutyric Acids; C100049:2-aminoisobutyric acid