Renin inhibition with A-64662: effect on blood pressure and hormonal response in man.
We studied the effects of intravenous injections of the renin inhibitor A-64662 on blood pressure, plasma renin activity (PRA), angiotensin II (Ang II) and aldosterone levels in patients with essential hypertension. While PRA was completely suppressed with doses as small as 0.001 microgram/kg, blood pressure was affected only in a few instances in doses of 0.4-1.0 mg/kg. In the six patients in whom Ang II and aldosterone results were available these hormones were concomitantly reduced with PRA, although the PRA inhibition lasted much longer (up to 24 h). There was little relationship between the blood pressure changes and plasma levels of renin activity, Ang II and aldosterone, suggesting that the plasma pool of these variables may not be the crucial factor determining blood pressure responses in patients with essential hypertension.
Bursztyn
M
M
Department of Medicine, Boston University School of Medicine, Massachusetts 02118.
Gavras
I
I
Tifft
C P
CP
Bauer
J H
JH
Melby
J C
JC
Gavras
H
H
D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000097:blood / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004151:Dipeptides / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D007275:Injections, Intravenous; D012083:Renin / Q000097:blood; D013997:Time Factors; D000092502:Renin Inhibitors
D000450:Aldosterone; D000804:Angiotensin II; D004151:Dipeptides; D012083:Renin; D000092502:Renin Inhibitors; C056622:enalkiren