title: [Diagnosis and treatment of malignant histiocytosis].
abstract: Of twelve patients with malignant histiocytosis admitted between 1974 and 1987, clinical symptoms, diagnostic procedures and the course of the disease were retrospectively evaluated. Predominant findings at physical examination were fever (11/12), splenomegaly (12/12), hepatomegaly (8/12), and lymphadenopathy (8/12). Laboratory findings included anaemia, leukocytopenia, thrombocytopenia, high lactate dehydrogenase, and jaundice. Positive diagnostic procedures included biopsies or aspirates of bone marrow (11/12), spleen (6/10), liver (7/9), lymph node (4/4), skin (1/2), lung (1/1) and blood (2/12). In seven patients treated with combination chemotherapy an average survival of 540 days was observed, while two long-term disease-free survivals were accomplished.
authors.forename: P
authors.initials: P
authors.lastname: Sonneveld
authors.forename: K
authors.initials: K
authors.lastname: van Lom
authors.forename: M E
authors.initials: ME
authors.lastname: Prins
authors.forename: M C
authors.initials: MC
authors.lastname: Kappers-Klunne
authors.forename: J
authors.initials: J
authors.lastname: Abels
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D054747:Histiocytic Sarcoma / Q000097:blood* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D007770:L-Lactate Dehydrogenase
vernacular_title: Diagnostiek en behandeling van maligne histiocytose.