Noradrenergic systems in human cerebellum.
Thin, beaded axons, immunostained with antisera to human dopamine beta-hydroxylase (DBH), were present in all layers of the anterior vermis of human cerebellum. This plexus appears similar to that described in rodents and provides information complementary to receptor autoradiographic studies that show significant noradrenergic innervation of mammalian cerebellum. Moreover, in two aged controls, we demonstrated abnormal, swollen, tortuous axons not visualized in young controls.
Powers
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Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.
O'Connor
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Price
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D000328:Adult; D000367:Age Factors; D000368:Aged; D002531:Cerebellum / Q000166:cytology / Q000378:metabolism*; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism*
D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine