[Effect of liposome-incorporated tubocurarine on the EEG of experimental animals].
The effect of tubocurarine enclosed in phosphatidylcholine and cholesterol liposomes on EEG of cats and rats was studied. Five to 15 minutes after its intravenous administration EEGs showed polyspike complexes as well as "peak-wave" complexes. Similar EEG changes were recorded on intracerebroventricular injection of tubocurarine solution. The absence of EEG changes after the injection is related to its poor permeability through the blood-brain barrier. The results obtained suggest that encapsulation of tubocurarine into liposomes facilitates its penetration through the blood-brain barrier.
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Filippov
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D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002415:Cats; D004337:Drug Carriers; D004569:Electroencephalography; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008081:Liposomes; D008297:Male; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology; D014403:Tubocurarine / Q000008:administration & dosage / Q000494:pharmacology*
D004337:Drug Carriers; D008081:Liposomes; D014403:Tubocurarine
O vliianii tubokurarina, vkliuchennogo v liposomy, na EEG éksperimental'nykh zhivotnykh.