title: Effect of methylene blue and cobaltous chloride on the alloxan-induced changes in collagen characteristics in the skin of garden lizard Calotes versicolor.
abstract: In the present study the effect of two chemicals such as methylene blue and CoCl2 on the accelerated ageing of collagen in alloxan-diabetic lizards has been tested. Both methylene blue and CoCl2 have been found to accelerate the ageing of collagen in normal lizards. While methylene blue enhanced the effects of alloxan in alloxanized lizards, CoCl2 tended to reverse it. It appears that methylene blue acts as a potentiator of alloxan; CoCl2, on the contrary, showed clear anti-ageing effects.
authors.affiliation: Postgraduate Department of Zoology, Berhampur University, Orissa, India.
authors.forename: G
authors.initials: G
authors.lastname: Mishra
authors.forename: H N
authors.initials: HN
authors.lastname: Behera
mesh_terms: D000375:Aging / Q000187:drug effects*; D000496:Alloxan / Q000494:pharmacology*; D000818:Animals; D003035:Cobalt / Q000494:pharmacology*; D003094:Collagen / Q000032:analysis / Q000502:physiology*; D004347:Drug Interactions; D008116:Lizards; D008751:Methylene Blue / Q000494:pharmacology*; D012867:Skin / Q000032:analysis*
chemical_list: D003035:Cobalt; D000496:Alloxan; D003094:Collagen; C018021:cobaltous chloride; D008751:Methylene Blue