title: HIV-2 in rhesus monkeys: serological, virological and clinical results.
abstract: Diseases induced by animal retroviruses are not considered to be good models for the human acquired immunodeficiency syndrome (AIDS) at present. The lack of an animal model for the human immunodeficiency virus (HIV) infection presents a main problem in the complete understanding of the pathogenesis of HIV-mediated diseases. Because of the homologies between simian immunodeficiency virus (SIV) and HIV-2, we inoculated rhesus monkeys with HIV-2 and HIV-2 adapted in vitro to monkey cells. One of the ten animals inoculated developed clinical symptoms that might be related to the infection with HIV-2.
authors.affiliation: Centre de Recherche du Service de Santé des Armées, Fontenay-aux-Roses, France.
authors.forename: D
authors.initials: D
authors.lastname: Dormont
authors.forename: J
authors.initials: J
authors.lastname: Livartowski
authors.forename: S
authors.initials: S
authors.lastname: Chamaret
authors.forename: D
authors.initials: D
authors.lastname: Guetard
authors.forename: D
authors.initials: D
authors.lastname: Henin
authors.forename: R
authors.initials: R
authors.lastname: Levagueresse
authors.forename: P F
authors.initials: PF
authors.lastname: van de Moortelle
authors.forename: B
authors.initials: B
authors.lastname: Larke
authors.forename: P
authors.initials: P
authors.lastname: Gourmelon
authors.forename: R
authors.initials: R
authors.lastname: Vazeux
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000382:microbiology* / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004569:Electroencephalography; D015483:HIV Antibodies / Q000096:biosynthesis*; D015498:HIV-2 / Q000276:immunology* / Q000502:physiology; D008214:Lymphocytes / Q000382:microbiology; D008251:Macaca; D008253:Macaca mulatta; D014779:Virus Replication
chemical_list: D015483:HIV Antibodies