title: Effect of cannabinoids on spasticity and ataxia in multiple sclerosis.
abstract: The chronic motor handicaps of a 30-year-old multiple sclerosis patient acutely improved while he smoked a marihuana cigarette. This effect was quantitatively assessed by means of clinical rating, electromyographic investigation of the leg flexor reflexes and electromagnetic recording of the hand action tremor. It is concluded that cannabinoids may have powerful beneficial effects on both spasticity and ataxia that warrant further evaluation.
authors.affiliation: Department of Clinical Neurophysiology, University of Göttingen, Federal Republic of Germany.
authors.forename: H M
authors.initials: HM
authors.lastname: Meinck
authors.forename: P W
authors.initials: PW
authors.lastname: Schönle
authors.forename: B
authors.initials: B
authors.lastname: Conrad
mesh_terms: D000328:Adult; D001259:Ataxia / Q000188:drug therapy* / Q000209:etiology; D002186:Cannabinoids / Q000627:therapeutic use*; D002188:Cannabis; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy*; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology
chemical_list: D002186:Cannabinoids