title: Vulvo-vaginal condylomatosis and relapse: combined treatment with electrocauterization and beta-interferon.
abstract: The therapeutical effectiveness of beta-interferon and the possibility of reducing the incidence of relapses were evaluated by selecting three groups of patients affected with three forms of condylomatosis and submitting then to various treatments. In the first group of sixty patients treated with beta-interferon, we obtained the best results in micro-condylomatosis (a 100% response), while florid condylomatosis responded less well to the treatment (72% with no response). In the second group of ten patients, electrocoagulation of florid condylomata determined a complete response (CR) in seven cases (70%). Moreover, immunoperoxidase identified three case of sub-clinical infection, two of which relapsed. In the third group of ten patients, we combined electrocoagulation with beta-interferon. This combination showed the effectiveness of beta-interferon in decreasing relapses. This result is evident if we consider that only one out of four patients with immunoperoxidase-positive biopsy relapsed.
authors.affiliation: Department of Gynaecology Obstetrics and Physiopathology of Human Reproduction II Faculty of Medicine, University of Naples, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Piccoli
authors.forename: M G
authors.initials: MG
authors.lastname: Santoro
authors.forename: C
authors.initials: C
authors.lastname: Nappi
authors.forename: M
authors.initials: M
authors.lastname: Capodanno
authors.forename: V
authors.initials: V
authors.lastname: De Santis
authors.forename: P C
authors.initials: PC
authors.lastname: La Torre
authors.forename: S
authors.initials: S
authors.lastname: Costa
authors.forename: U
authors.initials: U
authors.lastname: Montemagno
mesh_terms: D000293:Adolescent; D000328:Adult; D002425:Cautery; D003218:Condylomata Acuminata / Q000145:classification / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008875:Middle Aged; D012008:Recurrence; D014625:Vaginal Neoplasms / Q000145:classification / Q000473:pathology / Q000628:therapy*; D014846:Vulvar Neoplasms / Q000145:classification / Q000473:pathology / Q000628:therapy*
chemical_list: D007370:Interferon Type I