[Interleukin-1-inducing activity of the polysaccharide-containing antigens of the cell wall in Yersinia pestis].
The induction of the synthesis of interleukin-1 (IL-1) in human monocytes under the influence of the endotoxic preparations (LPS) and Y. pestis basis somatic antigen has been experimentally studied. The results obtained in this study make it possible to come to the conclusion that the capacity of the endotoxin of Y. pestis cell wall, consisting of LPS of type R, for inducing the synthesis of IL-1 in human monocytes is not different from the corresponding capacity of Salmonella and Shigella LPS, type S. Y. pestis O-specific polysaccharide in a discrete state has considerably greater IL-1-inducing activity in comparison with other preparations used in this experimental study. Such typical changes, characteristic of the initial stage of Y. pestis infection, as a sharp rise in temperature, transitory neutropenia, significant primary suppression of the oxygen-dependent metabolism of polymorphonuclear neutrophils are probably due to the induction of the synthesis of IL-1 by the polysaccharide-containing antigen of Y. pestis cell wall (LPS, basic somatic antigen) in cells of the mononuclear phagocytizing system.
Isin
Zh M
ZhM
Tugambaev
T I
TI
Tleulieva
R T
RT
Beliaev
N N
NN
Filimonov
N G
NG
D000942:Antigens, Bacterial / Q000494:pharmacology*; D002473:Cell Wall / Q000276:immunology; D002478:Cells, Cultured / Q000187:drug effects / Q000276:immunology; D003208:Concanavalin A / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D012486:Salmonella typhimurium / Q000276:immunology; D012763:Shigella flexneri / Q000276:immunology; D015010:Yersinia pestis / Q000276:immunology*
D000942:Antigens, Bacterial; D007375:Interleukin-1; D008070:Lipopolysaccharides; C009136:pyrogenal; D003208:Concanavalin A
Interleĭkin-1--indutsiruiushchaia aktivnost' polisakharidsoderzhashchikh antigenov kletochnoĭ stenki Yersinia pestis.