Renal haemodynamics during short-term angiotensin converting enzyme inhibition in normotensive normoalbuminuric insulin dependent diabetics.
Effective renal plasma flow (RPF) and glomerular filtration rate (GFR) were assessed in early insulin dependent diabetics (duration of diabetes less than 10 yr) during short term administration of angiotensin converting enzyme inhibitor. In a double blind randomized study, RPF and GFR were measured in normotensive normoalbuminuric (albumin excretion rate less than 20 micrograms/min) male IDDs before and after two weeks of Captopril 25 mg bd (n = 6) or placebo (n = 6). RPF and GFR were measured by means of a primed constant infusion of 125I iodohippurate and 51CR EDTA, respectively and corrected for 1.73m2 surface area. Supine blood pressure was measured throughout the study period. Mean (+/- SE) systolic and diastolic blood pressures were unchanged in both groups of subjects, being 124 +/- 5 mmHg and 78 +/- 4 mmHg before and 126 +/- 5 mm and 81 +/- 4 mm during Captopril and 121 +/- 6 mm and 79 +/- 4 mm before and 120 +/- 5 mm and 80 +/- 3 mm during placebo administration. RPF and GFR remained unchanged during Captopril administration, from 719 +/- 28 ml/min and 148 +/- 6 ml/min prior to and 721 +/- 26 ml/min and 149 +/- 6 ml/min during therapy. Similarly RPF and GFR were unchanged in the placebo treated group at 634 +/- 24 ml/min and 143 +/- 5 ml/min before end 630 +/- 28 ml/min and 140 +/- 7 ml/min after two weeks. Glycaemic control was unchanged in either group during the study period.(ABSTRACT TRUNCATED AT 250 WORDS)
Vora
J P
JP
Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK.
Hendre
T J
TJ
Atiea
J
J
Owens
D R
DR
D000293:Adolescent; D000328:Adult; D000419:Albuminuria; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology* / Q000652:urine; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D012079:Renal Circulation / Q000187:drug effects*
D002216:Captopril