title: [Radiotherapy of carcinoma of the oropharynx. Results of 10 years' experience at the University Hospital Center, Tours].
abstract: In our centre, the vast majority of patients with oropharyngeal tumours are treated by irradiation. Over a period of 10 years, between 1976 and 1986 we treated 305 patients with squamous carcinomas of the oropharynx. The mean age was 58.2 years. There were 24 women and 281 men. 59% of the patients had advanced tumours, classified as T3 or T4, 54% of the patients showed the presence of adenopathy at the first examination. All patients received radiation therapy. 69 patients had surgical treatment of the tumour or glands. 21 patients had implant therapy (most often combined with transcutaneous irradiation). 165 patients had induction chemotherapy. Local tumour control was obtained in 124 patients (41%), i.e. 82, 56, 31 and 4% for T1, T2, T3 and T4 respectively. The 5 years survival rate of the overall population was 28%. The principle causes of failure were local progression for T3 and T4 tumours and metastases and second cancers in patients with T1 or T2 tumours. The prognostic factors were gland involvement and general health. The site of the tumour, sex and histological type were not prognostic factors. Induction chemotherapy did not improve the results of treatment.
authors.affiliation: Clinique d'Oncologie et Radiothérapie, CHRU de Tours.
authors.forename: G
authors.initials: G
authors.lastname: Calais
authors.forename: D
authors.initials: D
authors.lastname: Goga
authors.forename: G
authors.initials: G
authors.lastname: Garand
authors.forename: P
authors.initials: P
authors.lastname: Beutter
authors.forename: O
authors.initials: O
authors.lastname: Le Floch
mesh_terms: D002277:Carcinoma / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D010610:Pharyngeal Neoplasms / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents
chemical_list: D011838:Radiation-Sensitizing Agents
vernacular_title: Radiothérapie des carcinomes de l'oropharynx. Résultats de 10 ans d'expérience au CHU de Tours.