[The action of a homologous series of ubiquinols on lipid peroxidation in brain mitochondrial and synaptosomal membranes].
The effects of inhibition of ubiquinols and ubiquinones with various length of isoprenoid chain on the lipid peroxidation in membranes of brain mitochondria and synaptosomes were studied. The efficiency of inhibition effects of ubiquinols depends on the length of isoprenoid chain. Ubiquinols with shorter isoprenoid chains demonstrated more effective inhibition.
Kagan
V E
VE
Tiurin
V A
VA
Kitanova
S A
SA
Serbinova
E A
EA
Quinn
P J
PJ
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D007425:Intracellular Membranes / Q000187:drug effects* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008563:Membrane Lipids / Q000378:metabolism*; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
D008563:Membrane Lipids; D014451:Ubiquinone; C003741:ubiquinol
Deĭstvie gomologicheskogo riada ubikhinolov na perekisnoe okislenie lipidov v membranakh mitokhondriĭ i sinaptosom mozga.