Cloning of rabbit uricase cDNA reveals a conserved carboxy-terminal tripeptide in three species.
cDNA clones encoding uricase have been isolated from a rabbit liver cDNA library. The nucleotide sequences of the cDNAs have been determined and those of the rat uricase cDNA have been revised. In all three uricases, the carboxy-terminal tripeptides are Ser-Arg/Lys-Leu sequences, which have recently been suggested as an essential element of peroxisomal targetting signals for many but not all peroxisomal proteins.
Motojima
K
K
Department of Biochemistry, Faculty of Pharmaceutical Science, Toho University, Funabashi, Japan.
Goto
S
S
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D003062:Codon / Q000235:genetics; D004247:DNA / Q000235:genetics*; D008099:Liver / Q000201:enzymology*; D008969:Molecular Sequence Data; D010944:Plants / Q000201:enzymology / Q000235:genetics; D011817:Rabbits; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D013025:Glycine max; D013045:Species Specificity; D014503:Urate Oxidase / Q000235:genetics*
D003062:Codon; D004247:DNA; D014503:Urate Oxidase