Acetylator phenotype in psoriasis.
Acetylator phenotype has been determined with sulfamethazine in 64 psoriatic patients and in 157 normal control subjects. Forty patients (62.5%) versus 90 control subjects (57.3%) were slow acetylators (p = NS). However, 81% of the 27 patients with psoriatic siblings were slow acetylators (p less than 0.05). Slow acetylator phenotype may be a genetic risk factor for the development of psoriasis.
Jiménez-Nieto
L C
LC
Department of Medicine, Hospital Universitario San Carlos, Universidad Complutense, Madrid, Spain.
Ladero
J M
JM
Fernández-Gundín
M J
MJ
Robledo
A
A
D000107:Acetylation; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D013418:Sulfamethazine / Q000378:metabolism
D013418:Sulfamethazine