First-trimester amniotic fluid acetylcholinesterase electrophoresis.
Acetylcholinesterase (AChE) gel electrophoresis was performed on normal amniotic fluids obtained at 4-15 weeks of pregnancy. Until 8 weeks, all the fluids were AChE-positive; the percentage of positive specimens decreased from 9 until 11 weeks and no positive specimen was found after 12 weeks. This method may allow early prenatal diagnosis of neural tube defects after the 12th week.
Muller
F
F
Hôpital Ambroise Paré, Boulogne, France.
Oury
J F
JF
Boue
A
A
D000110:Acetylcholinesterase / Q000378:metabolism*; D000653:Amniotic Fluid / Q000201:enzymology*; D004586:Electrophoresis; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis
D000110:Acetylcholinesterase