title: Comparison of bone marrow dosimetry and toxic effect of high dose 131I-labeled monoclonal antibodies administered to man.
abstract: 131I-labeled monoclonal antibodies were used in therapeutic trials in two potentially useful clinical situations: disseminated melanoma (intravenously administered Fab fragments; 21 patients) and disseminated peritoneal adenocarcinomatosis (intraperitoneal injection of IgG; 5 patients). Acute toxicity observed is consistent with mild bone marrow suppression of acute radiation syndrome and the observed toxicity is dose related in a manner that conforms to the expected human response to total body irradiation. For single doses of both i.p. administered and intravenously administered 131I-labeled anti-tumor antibodies, 100 rad to red marrow, calculated by the absorbed dose fraction method (MIRD), appeared to be a threshold below which significant acute toxicity was unlikely.
authors.affiliation: Department of Nuclear Medicine, National Institutes of Health, Bethesda, MD 20892.
authors.forename: S M
authors.initials: SM
authors.lastname: Larson
authors.forename: A
authors.initials: A
authors.lastname: Raubitschek
authors.forename: J C
authors.initials: JC
authors.lastname: Reynolds
authors.forename: R D
authors.initials: RD
authors.lastname: Neumann
authors.forename: K E
authors.initials: KE
authors.lastname: Hellstrom
authors.forename: I
authors.initials: I
authors.lastname: Hellstrom
authors.forename: D
authors.initials: D
authors.lastname: Colcher
authors.forename: J
authors.initials: J
authors.lastname: Schlom
authors.forename: E
authors.initials: E
authors.lastname: Glatstein
authors.forename: J A
authors.initials: JA
authors.lastname: Carrasquillo
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy / Q000556:secondary; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001853:Bone Marrow / Q000528:radiation effects*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008545:Melanoma / Q000532:radiotherapy; D009369:Neoplasms / Q000532:radiotherapy*; D010534:Peritoneal Neoplasms / Q000532:radiotherapy / Q000556:secondary; D011878:Radiotherapy / Q000009:adverse effects*
chemical_list: D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes