[Possible approaches to creating phospholipid preparations--acceptors of membrane cholesterol].
The capability of liposomes with plant phosphatidylcholine to extract cholesterol from erythrocyte membrane was investigated. It was shown, that plant phosphatidylcholine extracted 42% of membrane cholesterol, without causing haemolysis. This cholesterol extraction was responsible for the decrease of membrane microviscosity and for the increase of Na+, K+-ATPase activity. It is suggested that it is possible to create the extractive agent of cholesterol with plant phosphatidylcholine.
Khalilov
E M
EM
Torkhovskaia
T I
TI
Fortinskaia
E S
ES
Kaliman
A M
AM
Kochetova
M M
MM
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood / Q000302:isolation & purification*; D004337:Drug Carriers; D015195:Drug Design; D004355:Drug Stability; D004655:Emulsions; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D008081:Liposomes; D008563:Membrane Lipids / Q000097:blood / Q000302:isolation & purification*; D010713:Phosphatidylcholines / Q000494:pharmacology*; D011817:Rabbits
D000924:Anticholesteremic Agents; D004337:Drug Carriers; D004655:Emulsions; D008081:Liposomes; D008563:Membrane Lipids; D010713:Phosphatidylcholines; D002784:Cholesterol
Vozmozhnye podkhody k sozdaniiu fosfolipidnykh preparatov--aktseptorov membrannogo kholesterina.