title: Effects of pancreastatin on insulin and pancreatic polypeptide secretion in the dog.
abstract: Porcine pancreastatin (1.19 nmol) was administered into the peripheral vein (i.v.) or the third cerebral ventricle (i.t.v.) of dogs and its effect on the secretion of insulin and pancreatic polypeptide (PP) studied. Neither means of administration had any effect on basal and glucose-induced insulin or PP secretion. However, i.v. pancreastatin did inhibit the i.v. CCK-8-induced insulin but not PP release. Pancreastatin may thus play a role in the regulation of insulin secretion in the canine pancreas.
authors.affiliation: Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Inui
authors.forename: M
authors.initials: M
authors.lastname: Okita
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: N
authors.initials: N
authors.lastname: Sakatani
authors.forename: M
authors.initials: M
authors.lastname: Oya
authors.forename: H
authors.initials: H
authors.lastname: Morioka
authors.forename: M
authors.initials: M
authors.lastname: Oimomi
authors.forename: K
authors.initials: K
authors.lastname: Tatemoto
authors.forename: S
authors.initials: S
authors.lastname: Baba
mesh_terms: D000818:Animals; D053379:Chromogranin A; D004285:Dogs; D007262:Infusions, Intravenous; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D010187:Pancreatic Hormones / Q000494:pharmacology*; D010191:Pancreatic Polypeptide / Q000378:metabolism*; D010194:Pancreatin / Q000378:metabolism
chemical_list: D053379:Chromogranin A; D007328:Insulin; D010187:Pancreatic Hormones; C050836:pancreastatin; D010191:Pancreatic Polypeptide; D010194:Pancreatin