title: Effects of dilazep (Comelian) on the central purinergic system: inhibitory effects on clonidine-induced aggressive behavior.
abstract: Mice given clonidine (20-50 mg/kg i.p. and 5 micrograms i.c.v.) exhibited aggressive behavior. Dilazep as well as N6-(L-phenylisopropyl) adenosine (adenosine agonist) inhibited this behavior. Dilazep combined with N6-(L-phenylisopropyl) adenosine markedly inhibited the behavior at low doses that were without effect when given alone whereas the inhibitory effect of dilazep on the behavior was reversed by caffeine and 8-phenyltheophylline, which are adenosine antagonists. The results suggest that the inhibitory action of dilazep on clonidine-induced aggressive behavior can be substantially attributed to central purinoceptor stimulation.
authors.affiliation: Department of Neuropsychiatry, Yamaguchi University, School of Medicine, Ube, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Ushijima
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuki
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: H
authors.initials: H
authors.lastname: Kaneyuki
authors.forename: S
authors.initials: S
authors.lastname: Mashimoto
authors.forename: N
authors.initials: N
authors.lastname: Kajimura
authors.forename: M
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology*; D004109:Dilazep / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D010660:Phenylisopropyladenosine / Q000494:pharmacology; D011687:Purines / Q000502:physiology*; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D001381:Azepines; D011687:Purines; D010660:Phenylisopropyladenosine; D002110:Caffeine; D013806:Theophylline; C028322:8-phenyltheophylline; D004109:Dilazep; D003000:Clonidine