Basosquamous papilloma. A benign epithelial skin tumor with multiple cytogenetic clones.
Cytogenetic analysis of short-term cultures from a basosquamous papilloma revealed the following mosaic karyotype: 46,XX,t(2;5)(q31;q31),t(8;15)(p21;q21)/46,XX,t(7;17)(p13;p13)/47,XX, t(3;20)(q12;p13),+7/46,XX,t(1:12)(p12;q13). The finding of four abnormal, cytogenetically unrelated clones suggests a multicellular origin of this benign skin tumor. None of the structural rearrangements encountered have previously been associated with neoplasia.
Mertens
F
F
Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.
Heim
S
S
Jin
Y S
YS
Johansson
B
B
Mandahl
N
N
Biörklund
A
A
Wennerberg
J
J
Jonsson
N
N
Mitelman
F
F
D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D010212:Papilloma / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*