title: An approach to noninvasive fiber type determination by NMR.
abstract: In vivo 31P NMR spectroscopy was used to determine the ratios of creatine phosphate (PCr) to adenosine triphosphate (ATP) and inorganic phosphate (Pi) in leg and arm muscles of four sprinters, one marathon runner, and two sedentary subjects. Both ratios were definitely higher in the sprinters indicating that, since muscle ATP and Pi concentrations are constant, the PCr muscle content of these athletes is higher than usual. Sprinters are known to have higher percentages of fast-twitch fibers, which are richer in PCr than slow-twitch fibers. It is concluded that measurements of muscle ATP, PCr, and Pi through in vivo NMR spectroscopy could be used to determine muscle fiber composition.
authors.affiliation: IRCCS San Raffaele, Milano, Italy.
authors.forename: C A
authors.initials: CA
authors.lastname: Boicelli
authors.forename: A M
authors.initials: AM
authors.lastname: Baldassarri
authors.forename: C
authors.initials: C
authors.lastname: Borsetto
authors.forename: F
authors.initials: F
authors.lastname: Conconi
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D001132:Arm; D006801:Humans; D007866:Leg; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009132:Muscles / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus; D014142:Track and Field
chemical_list: D010710:Phosphates; D010725:Phosphocreatine; D010758:Phosphorus; D000255:Adenosine Triphosphate