title: Bidirectional stimulation of the white-opaque transition of Candida albicans by ultraviolet irradiation.
abstract: Most strains of Candida albicans are capable of switching spontaneously and at high frequency between a number of phenotypes distinguishable by colony morphology. The switching frequency of Candida albicans strain WO-1 between two predominant phenotypes, 'white' and 'opaque', and a minor phenotype, 'fuzzy', increased dramatically with low doses of ultraviolet irradiation that killed less than 20% of the population. The ultraviolet irradiation effect continued to be expressed over many generations as evidenced by stimulated sectoring. Ultraviolet irradiation stimulated switching in both the white-to-opaque and opaque-to-white direction, suggesting that a common mechanism functions in both directions.
authors.affiliation: Department of Biology, University of Iowa, Iowa City 52242.
authors.forename: B
authors.initials: B
authors.lastname: Morrow
authors.forename: J
authors.initials: J
authors.lastname: Anderson
authors.forename: J
authors.initials: J
authors.lastname: Wilson
authors.forename: D R
authors.initials: DR
authors.lastname: Soll
mesh_terms: D002176:Candida albicans / Q000254:growth & development / Q000528:radiation effects*; D010641:Phenotype; D014466:Ultraviolet Rays