title: Evaluation of a single intravitreal injection of 5-fluorouracil in vitrectomy cases.
abstract: To evaluate the efficacy and toxicity of 5-fluorouracil (5-FU) after pars plana vitrectomy, 51 eyes were followed in a prospective and randomized clinical trial in which, upon completion of surgery, 26 eyes received 10 mg intravitreal 5-FU and 25 control eyes did not receive 5-FU. The only possible sign of 5-FU toxicity was prolonged corneal epithelial edema. Visual acuities of 20/200 or better were obtained in 67% of the 5-FU group and 56% of the control group. Successful macular reattachment was obtained in 60% of the 5-FU group and 77% of the control group. None of the eyes in either group developed substantial intraocular proliferation or membranes. The findings indicate that a single 10-mg intravitreal injection of 5-FU is well tolerated without permanent toxic damage.
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33101.
authors.forename: G W
authors.initials: GW
authors.lastname: Blankenship
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000187:drug effects; D002386:Cataract / Q000139:chemically induced; D002986:Clinical Trials as Topic; D003315:Cornea / Q000187:drug effects / Q000473:pathology; D005069:Evaluation Studies as Topic; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000633:toxicity*; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011897:Random Allocation; D014792:Visual Acuity / Q000187:drug effects; D014821:Vitrectomy; D014822:Vitreous Body / Q000187:drug effects*
chemical_list: D005472:Fluorouracil