title: [The placental barrier: structure, resistance, asymmetry].
abstract: The concept of placental barrier has been evaluated using recent advances in ultrastructure and in transport physiology. On a structural basis, the barrier effect is grounded by the syncytiotrophoblast continuity, and by basal and plasma membrane's electrical charges and by basement membrane porosity. The aqueous phase continuity for diffusion operates through intercellular gap, fenestrations (rat, rabbit) and transcellular channels (guinea pig). However, these connections are not apparent in the human syncytiotrophobast. For the molecular size selectivity, the hemochorial placentas with a pore radius of 10 nm appear much less selective than the epitheliochorial ones. The metabolic capacity of the placental cells (trophoblast, macrophages) participates to the barrier effect by metabolizing or by converting some substrates. Similarly, trophoblast asymmetry in the location of enzymes, carriers and receptors on outer (maternal side) and on basal (fetal side) plasma membranes, and in the release of secretory products, contributes to maintain separate fetal and maternal compartments. The functional polarity of trophoblast is expressed in metabolism (corticostéroids), nutrients (amino acids) and ions (iron) transport, and most of its secretions (hPL, hCG, SP1).
authors.affiliation: Université Pierre-et-Marie Curie, biologie de la reproduction, Paris, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Challier
mesh_terms: D001693:Biological Transport, Active / Q000502:physiology; D002352:Carrier Proteins / Q000378:metabolism; D004730:Endothelium, Vascular / Q000648:ultrastructure; D005260:Female; D006644:Histiocytes / Q000378:metabolism; D006801:Humans; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D008564:Membrane Potentials; D010920:Placenta / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*; D011247:Pregnancy; D014327:Trophoblasts / Q000473:pathology / Q000502:physiology
chemical_list: D002352:Carrier Proteins
vernacular_title: La barrière placentaire: structure, résistance, asymétrie.