title: [Determination of tumor-associated trypsin inhibitor (TATI) in subjects with gastrointestinal diseases. Preliminary data].
abstract: Tumor-associated trypsin inhibitor (TATI) is a 6 K dalton protease inhibitor, that was isolated from urine of a patient with ovarian cancer. In our experience, mean serum level of TATI in healthy subjects (n. 120), is 13 micrograms/l (range 5.1-42 micrograms/l). The cut-off point is established in 32 micrograms/l (mean +/- 3 SD). We have examined 357 patients with gastrointestinal diseases: 98 gastric cancer, 50 colon cancers, 52 pancreatic cancers, 32 chronic pancreatitis, 38 IBD, 28 colon polyps, 40 gastric ulcers and 25 non-neoplastic biliary tree diseases. TATI may be a good tumor marker only in gastric cancer. Elevated levels of TATI also occur in obstructive hepatobiliary disease and active pancreatitis or IBD.
authors.affiliation: Divisione di Gastroenterologia, Ospedale Maggiore San Giovanni Battista Molinette, Torino.
authors.forename: P
authors.initials: P
authors.lastname: Piantino
authors.forename: R
authors.initials: R
authors.lastname: Mosso
authors.forename: R
authors.initials: R
authors.lastname: Polloni
authors.forename: A
authors.initials: A
authors.lastname: Cerchier
authors.forename: G
authors.initials: G
authors.lastname: Gennaretti
authors.forename: E
authors.initials: E
authors.lastname: Daziano
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D014408:Biomarkers, Tumor / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005260:Female; D005767:Gastrointestinal Diseases / Q000097:blood*; D005770:Gastrointestinal Neoplasms / Q000097:blood; D006801:Humans; D008297:Male; D011863:Radioimmunoassay / Q000295:instrumentation; D011933:Reagent Kits, Diagnostic; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000097:blood*; D014361:Trypsin Inhibitors / Q000097:blood*
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D011933:Reagent Kits, Diagnostic; D014361:Trypsin Inhibitors; D014359:Trypsin Inhibitor, Kazal Pancreatic
vernacular_title: Dosaggio del tumor associated trypsin inhibitor (TATI) in soggetti con malattie gastrointestinali. Dati preliminari.