A comparison of the effects of chromate, molybdate and cadmium oxide on respiration in the yeast Saccharomyces cerevisiae.
Growth of Saccharomyces cerevisiae on non-fermentable medium was more sensitive to inhibition by chromate than growth on fermentable medium. Chromate was selectively toxic against oxygen uptake in cells grown in non-fermentable medium and also induced petite mutations. CdO demonstrated similar but lesser effects on growth and respiration. However, molybdate had little toxicity to yeast non-fermentable growth and stimulated oxygen uptake in cells grown in fermentable and non-fermentable media. These results suggest that chromate, a carcinogen, may act more directly against the mitochondria of S. cerevisiae than related chemical species, CdO and molybdate.
Henderson
G
G
School of Biological Sciences and Environmental Health, Thames Polytechnic, London, UK.
D002104:Cadmium / Q000633:toxicity*; D019187:Cadmium Compounds; D002840:Chromates / Q000633:toxicity*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D008982:Molybdenum / Q000633:toxicity*; D009154:Mutation; D010087:Oxides; D010101:Oxygen Consumption / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
D019187:Cadmium Compounds; D002840:Chromates; D010087:Oxides; D002104:Cadmium; C029663:cadmium oxide; C044659:molybdate; D008982:Molybdenum