Dependence of proliferation of Bacteroides forsythus on exogenous N-acetylmuramic acid.
Bacteroides forsythus is the first wild-type or mutant bacterium found to require exogenous N-acetylmuramic acid for proliferation and maintenance of cell shape. This implies so far unknown pathways for peptidoglycan synthesis and a strict dependence of B. forsythus on other bacteria in its oral habitat. Addition of N-acetylmuramic acid to conventional bacteriological media allows routine cultivation of this fastidious organism.
Wyss
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Department of Oral Microbiology and General Immunology, University of Zurich, Switzerland.
D001439:Bacteroides / Q000187:drug effects / Q000254:growth & development*; D003470:Culture Media / Q000032:analysis; D006133:Growth Substances / Q000032:analysis / Q000494:pharmacology; D009112:Muramic Acids / Q000096:biosynthesis / Q000494:pharmacology*; D013400:Sugar Acids / Q000494:pharmacology*
D003470:Culture Media; D006133:Growth Substances; D009112:Muramic Acids; D013400:Sugar Acids; C031651:N-acetylmuramic acid