title: Effects of progesterone and oestradiol-17 beta on 17 beta-ol-dehydrogenase activity in stromal cells of human endometrium under in-vitro conditions.
abstract: A 17 beta-ol-dehydrogenase activity could be demonstrated in fibroblast monolayer cell cultures of proliferative human endometrium. After 24 h incubation 100 nCi [6,7-3H]oestradiol-17 beta was completely oxidized to oestrone. Progesterone was not able to enhance the metabolizing velocity. In contrast, progesterone incubation revealed a decreasing oxidation rate with increasing molarity. Histological changes after transformation of the endometrium are discussed to explain in-vivo results showing an increased 17 beta-ol-dehydrogenase activity in the secretory phase of the cycle.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Freiburg, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Neulen
authors.forename: B
authors.initials: B
authors.lastname: Wagner
authors.forename: U
authors.initials: U
authors.lastname: Flecken
authors.forename: M
authors.initials: M
authors.lastname: Breckwoldt
mesh_terms: D015067:17-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D002478:Cells, Cultured; D004717:Endometrium / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D004958:Estradiol / Q000378:metabolism / Q000494:pharmacology*; D004960:Estradiol Dehydrogenases / Q000378:metabolism*; D004970:Estrone / Q000378:metabolism; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D008597:Menstrual Cycle; D011374:Progesterone / Q000494:pharmacology*
chemical_list: D004970:Estrone; D011374:Progesterone; D004958:Estradiol; D015067:17-Hydroxysteroid Dehydrogenases; D004960:Estradiol Dehydrogenases