title: Therapeutic monitoring of metipamide during antihypertensive therapy.
abstract: The aim of our study was to monitor metipamide during a two-month period of treatment and to determine whether the whole-blood levels estimated by high-performance liquid chromatography provide a relevant indicator of possible accumulation of the drug. We also analysed antihypertensive activity and biochemical changes in the blood of twenty hypertonic patients. The results of our clinical trial showed that metipamide is an effective first-line antihypertensive agent, in that it combines satisfactory reduction of blood pressure with a low frequency of side-effects and a simple once-daily dosage regime.
authors.affiliation: Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia.
authors.forename: J
authors.initials: J
authors.lastname: Klíma
authors.forename: J
authors.initials: J
authors.lastname: Grafnetterová
authors.forename: Z
authors.initials: Z
authors.lastname: Kubelka
authors.forename: J
authors.initials: J
authors.lastname: Klíma
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000097:blood / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D007190:Indapamide / Q000031:analogs & derivatives / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; C050506:metipamide; D007190:Indapamide