title: [Necrosis of the bone marrow and cancer].
abstract: Bone marrow necrosis (BMN) is a rare complication and is characterized by the presence of an eosinophilic amorphous material in the bone marrow. The clinical, analytical and histological characteristics of 4 patients with BMN associated to a neoplastic process are described. One of them was a gastric cancer but the neoplastic origin could not de determined in the other three cases. Three patients presented bone pain, but in all four patients thrombopenia, anemia, leuko-erythroblastic reaction and elevated LDH was found. A literature review is carried out and the possible physiopathological mechanisms are discussed.
authors.forename: J
authors.initials: J
authors.lastname: Feliu
authors.forename: P
authors.initials: P
authors.lastname: González-Peramato
authors.forename: J
authors.initials: J
authors.lastname: Vicente
authors.forename: C
authors.initials: C
authors.lastname: García-Girón
authors.forename: M
authors.initials: M
authors.lastname: González Barón
authors.forename: J M
authors.initials: JM
authors.lastname: Montero
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009369:Neoplasms / Q000150:complications*; D011379:Prognosis
vernacular_title: Necrosis de médula ósea y cáncer.