[Prenatal diagnosis of several hereditary skin diseases].
Twenty-two control women and 5 women at risk for delivering a baby with Brocq's ichthyosiform erythroderma or fatal epidermolysis bullosa were investigated in order to make prenatal diagnosis of inherited fetal skin diseases. Fetal skin abnormalities were detected in 3 of the 5 high-risk patients, and their pregnancies were terminated. There was a spontaneous abortion with a normal fetus in 1 case. In one woman, pregnancy progressed to term delivery of a normal girl. Methodologic aspects of obtaining fetal skin samples and the results of their morphologic studies are discussed.
Bakharev
V A
VA
Karetnikova
N A
NA
Mordovtsev
V N
VN
Aĭvazian
A A
AA
Iantovskiĭ
Iu R
IuR
D001706:Biopsy; D004820:Epidermolysis Bullosa / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007057:Ichthyosis / Q000175:diagnosis* / Q000473:pathology; D007231:Infant, Newborn; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012867:Skin / Q000473:pathology
Prenatal'naia diagnostika nekotorykh nasledstvennykh zabolevaniĭ kozhi.