title: Hemopoietins for eosinophils. Glycoprotein hormones that regulate the development of inflammation in eosinophilia-associated disease.
abstract: Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5) are T lymphocyte-derived glycoproteins that stimulate the development of eosinophils from bone marrow precursors. These eosinophil hemopoietins also regulate functions of mature eosinophils, enhancing their ability to infiltrate tissues and to secrete biologically active substances at the tissue site. In these ways, the eosinophil hemopoietins have a major impact on the development of eosinophilia-associated disease.
authors.affiliation: Department of Medicine, Harvard Medical School, Boston, Massachusetts.
authors.forename: D S
authors.initials: DS
authors.lastname: Silberstein
authors.forename: K F
authors.initials: KF
authors.lastname: Austen
authors.forename: W F
authors.initials: WF
authors.lastname: Owen
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D002454:Cell Differentiation / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003524:Cyclosporins / Q000627:therapeutic use; D016207:Cytokines; D004802:Eosinophilia / Q000188:drug therapy / Q000503:physiopathology; D004804:Eosinophils / Q000187:drug effects* / Q000502:physiology; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007249:Inflammation
chemical_list: D001685:Biological Factors; D003524:Cyclosporins; D016207:Cytokines