title: Caffeine pharmacokinetics in preterm infants older than 2 weeks.
abstract: We studied 17 preterm infants receiving caffeine, and measured their plasma levels of caffeine and the theophylline metabolite by high-pressure liquid chromatography. The half-life was calculated by computer analysis using the least-square method. The mean gestational age of our patients was 29.7 +/- 1.9 weeks (mean +/- SD) and they were studied at 20.7 +/- 6.6 days (mean +/- SD) postnatal age. The caffeine half-life was 52.03 +/- 23.87 h (means +/- SD) and the theophylline half-life was 77.04 +/- 65.01 h (mean +/- SD).
authors.affiliation: Department of Pediatrics, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.
authors.forename: S A
authors.initials: SA
authors.lastname: Pearlman
authors.forename: C
authors.initials: C
authors.lastname: Duran
authors.forename: M A
authors.initials: MA
authors.lastname: Wood
authors.forename: M J
authors.initials: MJ
authors.lastname: Maisels
authors.forename: C M
authors.initials: CM
authors.lastname: Berlin
mesh_terms: D002110:Caffeine / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D012891:Sleep Apnea Syndromes / Q000188:drug therapy; D013806:Theophylline / Q000097:blood / Q000378:metabolism
chemical_list: D002110:Caffeine; D013806:Theophylline