title: Antihepatotoxic principles of Solanum capsicastrum.
abstract: Two new steroidal alkaloids named capsimine and isocapsicastrine were isolated from the root bark of Solanum capsicastrum. Their structures were elucidated by chemical degradation and spectral data as (22R, 25R)-22,26-epiminocholest-5-ene-3 beta, 16 alpha-diol and (22S,25S)-O(3)-beta-D-glucopyranosyl-22,26-epiminocholest-5-ene-3 beta-16 alpha-diol, respectively. Capsicastrine, capsicastrine acetate, isoteinemine acetate, and etioline exhibited strong activity against liver damage induced by CCl4.
authors.forename: C N
authors.initials: CN
authors.lastname: Lin
authors.forename: K H
authors.initials: KH
authors.lastname: Gan
mesh_terms: D000818:Animals; D008107:Liver Diseases / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D012991:Solanaceous Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D012991:Solanaceous Alkaloids; C059671:capsimine; C059672:isocapsicastrine