title: [Antiphlogistic effect of bromelaine following third molar removal].
abstract: A placebo-controlled double-blind study of 100 patients with impacted and/or dislocated lower wisdom teeth was conducted to examine the tolerance and antiphlogistic efficacy of bromelaine--a mixture of proteolytic enzymes from ananas comosus. Treatment was started 1 day prior to third molar surgery with a daily dose of 3 x 80 mg and was continued for a total of 6 days. On the 1st day following surgery, linear measurement (distance: tragus-pogonion) showed swelling to be 7.5% lower under drug treatment than in the placebo group. Two-dimensional image evaluation increased this difference to 15.9%, which however still failed to attain the significance level of 20%. Between the 3rd and the 7th postoperative day no differences were found between the two groups regarding the extent of soft tissue swelling or the speed of edema resolution.
authors.forename: G
authors.initials: G
authors.lastname: Hotz
authors.forename: T
authors.initials: T
authors.lastname: Frank
authors.forename: J
authors.initials: J
authors.lastname: Zöller
authors.forename: H
authors.initials: H
authors.lastname: Wiebelt
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001963:Bromelains / Q000627:therapeutic use*; D004311:Double-Blind Method; D004487:Edema / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008964:Molar, Third / Q000601:surgery; D011292:Premedication; D016032:Randomized Controlled Trials as Topic; D014081:Tooth Extraction / Q000009:adverse effects*; D014095:Tooth, Impacted / Q000601:surgery
chemical_list: D001963:Bromelains
vernacular_title: Zur antiödematösen Wirksamkeit von Bromelain nach operativer Weisheitszahnentfernung.