Lymphokines facilitate maturation of oligodendrocytes in vitro.
As oligodendrocytes develop in vitro, A2B5+ progenitor cells acquire the oligodendrocyte-specific marker, galactocerebroside (GalC), to become A2B5+ GalC+ cells. They then gradually lose reactivity to A2B5, to become A2B5- GalC+ mature oligodendrocytes. By examining this developmental surface antigen expression with and without lymphokine stimuli we found that crude lymphokines, but not interleukin-2 or gamma-interferon, facilitate this maturation process. Thus, lymphokines may have a role in differentiation of oligodendrocytes. The same lymphokine stimuli, however, did not enhance the proliferation of oligodendrocytes.
Suzumura
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Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104.
Silberberg
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DH
D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D005699:Galactosylceramides / Q000276:immunology / Q000378:metabolism; D008222:Lymphokines / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009457:Neuroglia / Q000166:cytology*; D009836:Oligodendroglia / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D005699:Galactosylceramides; D008222:Lymphokines