Clear-cell syringoma. Immunohistochemistry and electron microscopy study.
Clear-cell syringoma is a histologic variant of syringoma that is otherwise clinically indistinguishable from ordinary syringoma. This variant is formed by cells that have pale or clear cytoplasm as a result of glycogen accumulation. There is a high association of clear-cell syringoma and diabetes mellitus. A case of clear-cell syringoma associated with diabetes mellitus is described. Electron microscopic examination revealed that periluminal cells showed intra- and extracytoplasmic multivesicular bodies that may be characteristic of the clear-cell variant. Immunohistochemistry for carcinoembryonic antigen (CEA) showed ordinary syringomas as in the presence of CEA within and surrounding duct-like spaces.
Ambrojo
P
P
Department of Dermatology, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Spain.
Requena Caballero
L
L
Aguilar Martínez
A
A
Sánchez Yus
E
E
Furió
V
V
D000236:Adenoma / Q000032:analysis / Q000648:ultrastructure*; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003593:Cytoplasm / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004848:Epithelium / Q000648:ultrastructure; D005142:Eyelid Neoplasms / Q000032:analysis / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D013544:Sweat Gland Neoplasms / Q000032:analysis / Q000648:ultrastructure*
D002272:Carcinoembryonic Antigen