title: [Relation of hepatitis B virus markers in the serum and hepatic tissue in chronic carriers of HBsAg].
abstract: The authors studied 23 chronic carriers of HBsAg, to classify them in terms of serology, histopathologic findings and behaviour of markers HBsAg and HBcAg in hepatic tissue. Immunohistochemical techniques were used to establish possible relations between these parameters. Among patients with positive HBeAg found all exhibited HBcAg in hepatic tissue, but in 16 patients in which HBeAg was negative, liver HBcAg was positive in 3 cases (18.7%). No correlation was found between the HBeAg system/anti-HBe and histopathologic findings because chronic active hepatitis was observed in 6/8 anti-HBe positive patients (75%). These findings suggest that, the evaluation of chronic carriers of HBsAg, requires a histologic analysis of the liver, including a tissue research for the virus in addition to a complete serologic study of HBV.
authors.forename: M L
authors.initials: ML
authors.lastname: Ferraz
authors.forename: V P
authors.initials: VP
authors.lastname: Lanzoni
authors.forename: A E
authors.initials: AE
authors.lastname: Silva
authors.forename: V N
authors.initials: VN
authors.lastname: Alberti
authors.forename: C A
authors.initials: CA
authors.lastname: Pereira
authors.forename: V
authors.initials: V
authors.lastname: Chiferi Júnior
authors.forename: R X
authors.initials: RX
authors.lastname: Guimarães
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002353:Carrier State / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis* / Q000276:immunology; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis; D006521:Hepatitis, Chronic / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D008099:Liver / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens
vernacular_title: Relação entre marcadores do vírus da hepatite B (VHB) no soro e no tecido hepático em pacientes portadores crônicos do HBsAg.