Vitamin K1 and K2 in infant human liver.
It is not known to what extent humans store vitamin K in liver. We measured hepatic concentrations of vitamin K1 (phylloquinone) and K2 (menaquinones) in 11 human livers (eight infants and three adults). Relatively small amounts of vitamin K were found in the liver at any age compared to other fat soluble vitamins. Vitamin K1 was the predominant form with much smaller concentrations of vitamin K2. Long-chain menaquinones (vitamin K2) were readily identified in most liver specimens. Hepatic vitamin K2 concentrations also increased with increasing age. These observations have implications for vitamin K supplementation in infants.
Kayata
S
S
Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53201.
Kindberg
C
C
Greer
F R
FR
Suttie
J W
JW
D000328:Adult; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014812:Vitamin K / Q000378:metabolism*; D010837:Vitamin K 1 / Q000378:metabolism*
D014812:Vitamin K; D010837:Vitamin K 1