Superficial spreading melanoma with a nodular area: antigenic phenotype of the radial and vertical growth areas.
We investigated antigenic features associated with different tumor progression steps in primary melanoma, interpreted as different patterns of growth (radial and vertical) in the same and in different lesions. Thirty-eight primary melanomas were examined: 18 superficial spreading malanomas, 13 superficial spreading melanomas with a nodular area and 7 nodular melanomas. 225.28,763.74, CL.203, VF19LL209, VF19LL217, Q5.13, W6.32 and anti-HLA-DR monoclonal antibodies were used. Phenotypic differences between radial and vertical growth areas were observed but no statistical significance could be found.
Brogelli
L
L
Clinica Dermatologica II dell'Università degli Studi di Frienze, Italy.
Moretti
S
S
Giannotti
B
B
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D008545:Melanoma / Q000276:immunology* / Q000473:pathology; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000032:analysis; D010641:Phenotype
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D006684:HLA-DR Antigens; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins