The pattern-evoked electroretinogram (PERG): age-related alterations and changes in glaucoma.
Pattern-onset electroretinograms (PERGs) were studied in 147 normal subjects of different ages (14-79 years) and in 110 eyes of 65 patients with glaucoma or ocular hypertension. The responses showed an increase (P less than 0.001) in peak latency with increasing age and a decrease (P less than 0.001) in amplitude which approximately parallels the loss of ganglion cells estimated by other authors. Many glaucoma eyes showed a loss of the normally present spatial tuning. In the age group above 50 years 50% of the onset responses were significantly diminished and the peak latencies were not significantly different. A negative correlation (P less than 0.001) was found between the size of the PERG and the cup/disc ratio and a positive correlation (P less than 0.001) with the area of the neuroretinal rim of the optic disc. The PERG decreased (P less than 0.01) with increasing visual field losses.
Korth
M
M
Augenklinik der Universität, Erlangen, Federal Republic of Germany.
Horn
F
F
Storck
B
B
Jonas
J
J
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D004596:Electroretinography / Q000379:methods*; D005074:Evoked Potentials, Visual; D005901:Glaucoma / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D014794:Visual Fields