title: Sister chromatid exchange-related characteristics of excision repair-proficient xeroderma pigmentosum cells.
abstract: A high incidence of skin cancer characterizes patients with xeroderma pigmentosum (XP). XP patients have hereditary defects in repair mechanisms of ultraviolet light (UV)-induced damage to DNA. Progress in elucidating the pathogenesis of cutaneous cancers can be expected by analysis of the biologic defects of cultured cells from XP patients. Such information may also contribute, at least in part, to an understanding of carcinogenesis in general.
authors.affiliation: Department of Pharmacology, Research Institute for Tuberculosis and Cancer, Tohoku University, Sendai, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Oikawa
authors.forename: H
authors.initials: H
authors.lastname: Tohda
mesh_terms: D000328:Adult; D002110:Caffeine / Q000494:pharmacology; D002478:Cells, Cultured; D004247:DNA / Q000187:drug effects* / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D006801:Humans; D008875:Middle Aged; D012854:Sister Chromatid Exchange / Q000187:drug effects* / Q000528:radiation effects; D012878:Skin Neoplasms / Q000235:genetics*; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000235:genetics*
chemical_list: D002110:Caffeine; D004247:DNA