title: The influence of intestinal resection on the growth of intestinal neomucosa.
abstract: Intestinal resection stimulates proliferative activity in the intestinal remnant. The aim of this study was to determine the influence of intestinal resection on the growth of intestinal neomucosa. Forty-eight New Zealand white rabbits had 2 x 5-cm ileal defects patched with adjacent cecal serosal surface. Group I (n = 24) served as controls. Group II (n = 24) underwent simultaneous 50% enterectomy. Neomucosal coverage was significantly greater in Group II at 1 week (36 +/- 11% vs 67 +/- 9%, P less than 0.05) and 2 weeks (94 +/- 2% vs 99 +/- 1%, P less than 0.05), but was similar at 3 and 4 weeks. There was significantly more neomucosa at 1 week in the animals that underwent resection (134 +/- 55 mm2 vs 199 +/- 54 mm2, P less than 0.05). Degree of patch contraction, glucose uptake, and disaccharidase activities were similar in each group. Ornithine decarboxylase activity and crypt cell production rate were significantly greater at 1 week in the animals that underwent resection. Intestinal resection results in an early increase in neomucosal growth and increased proliferative activity. Since contraction of the patches occurs to a similar extent in both groups, the total amount of neomucosa was not increased. Thus, performing patching at the time of resection is not necessary for optimal growth.
authors.affiliation: Omaha Veterans Administration Medical Center, Nebraska.
authors.forename: L E
authors.initials: LE
authors.lastname: Bragg
authors.forename: J S
authors.initials: JS
authors.lastname: Thompson
mesh_terms: D000818:Animals; D002455:Cell Division; D002465:Cell Movement; D004186:Disaccharidases / Q000378:metabolism; D004847:Epithelial Cells; D005947:Glucose / Q000378:metabolism; D007413:Intestinal Mucosa / Q000166:cytology / Q000201:enzymology / Q000254:growth & development*; D007422:Intestines / Q000601:surgery*; D009955:Ornithine Decarboxylase / Q000378:metabolism; D011184:Postoperative Period; D011817:Rabbits
chemical_list: D004186:Disaccharidases; D009955:Ornithine Decarboxylase; D005947:Glucose