[Effects of prophylactically used latamoxef with tobramycin against postoperative infections on therapeutic drug monitoring and renal function in the field of obstetrics and gynecology].
Latamoxef (LMOX) and tobramycin (TOB) were administered to 50 patients via intravenous drip infusion to prevent postoperative infections in the field of obstetrics and gynecology. Blood levels of TOB were determined, and effects of the combined use of TOB and LMOX on renal functions were clinically studied. The results obtained are summarized as follows: 1. Determination of blood levels of TOB after intravenous drip infusion of 90 mg TOB with 1 g LMOX revealed a peak at the end of drip infusion, and thereafter the levels decreased rapidly. The maximum level and the level upon commencement of the next administration were within the safe range. 2. Clinical laboratory test before and after surgery using markers of renal functions (BUN, creatinine, beta 2-MG and NAG) revealed a tendency for slight increases in BUN and NAG, but no significant differences were shown. 3. There were no abnormalities in other clinical laboratory parameters or any appearance of subjective or objective side effects.
Chimura
T
T
Department of Obstetrics and Gynecology, School of Medicine, Yamagata University.
Hirayama
T
T
Ogawa
T
T
Shiina
Y
Y
D000328:Adult; D001424:Bacterial Infections / Q000517:prevention & control*; D002585:Cesarean Section; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004361:Drug Tolerance; D005260:Female; D005831:Genital Diseases, Female / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007044:Hysterectomy; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007677:Kidney Function Tests; D008875:Middle Aged; D009070:Moxalactam / Q000008:administration & dosage / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D011292:Premedication; D014031:Tobramycin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*
D009070:Moxalactam; D014031:Tobramycin