Prophylaxis in caesarean section with cefmetazole and cefoxitin.
A prospective, randomized, open comparison of three 1 g doses of cefmetazole with three 2 g doses of cefoxitin for non-elective Caesarean section was performed. Sixty-nine patients were evaluated. The two groups were comparable with respect to labour characteristics that might influence risk of postoperative infectious morbidity. Similarly, the nature of the bacterial contamination/infection of the amniotic fluid at the time of Caesarean section was comparable in the two groups. The only infectious morbidity noted was endomyometritis. The incidence was the same in both groups, 5/50 (10%) in the cefmetazole group and 2/19 (10.5%) in the cefoxitin group. Febrile morbidity, as reflected in the fever index, was not significantly different between the groups, 10.2 +/- 18.5 degree hours in the cefmetazole group and 7.5 +/- 11.7 degree hours in the cefoxitin group. Cefmetazole appeared to be equivalent to cefoxitin in reducing post-Caesarean section endomyometritis.
Crombleholme
W R
WR
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco.
Green
J R
JR
Ohm-Smith
M
M
DeKay
V
V
Klaisle
C
C
Luft
J
J
Robbie
M
M
Dahrouge
D
D
Sweet
R L
RL
D000293:Adolescent; D000328:Adult; D000653:Amniotic Fluid / Q000382:microbiology; D001420:Bacteria, Aerobic / Q000302:isolation & purification; D001421:Bacteria, Anaerobic / Q000302:isolation & purification; D015311:Cefmetazole / Q000627:therapeutic use*; D002440:Cefoxitin / Q000627:therapeutic use*; D002585:Cesarean Section; D004717:Endometrium / Q000382:microbiology; D005260:Female; D006801:Humans; D011247:Pregnancy; D011292:Premedication; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*
D015311:Cefmetazole; D002440:Cefoxitin