title: Effect of estradiol on the phosphorylation of rat liver ribosome proteins.
abstract: The effect of estradiol on phosphorylation with gamma-32P-ATP of ribosome proteins from polyribosome fraction, isolated from female rat liver is found out. Rats (180 g) used were: sham-operated, ovariectomized and treated after ovariectomy for 11 days with 20 micrograms 17 beta-estradiol-dipropionate per 100 g body weight. The estradiol deficiency after ovariectomy decreased phosphorylation, but the estrogenization of ovariectomized rats increases it twice. In vitro the hormone (1-2 mumol/l) [corrected] also stimulated ribosome protein phosphorylation. It is supposed that the hormone may take part in the regulation of protein synthesis in the translational region of the process.
authors.affiliation: Department of Human and Animal Physiology, Faculty of Biology, University of Sofia, Bulgaria.
authors.forename: J T
authors.initials: JT
authors.lastname: Nikolov
authors.forename: O A
authors.initials: OA
authors.lastname: Dimitrov
authors.forename: S D
authors.initials: SD
authors.lastname: Kabaivanova
authors.forename: V L
authors.initials: VL
authors.lastname: Ivanova
authors.forename: V V
authors.initials: VV
authors.lastname: Moskova
mesh_terms: D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010052:Ovariectomy; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains; D012269:Ribosomal Proteins / Q000378:metabolism*
chemical_list: D012269:Ribosomal Proteins; D004958:Estradiol