title: A uterine leiomyoma showing both t(12;14) and del(7) abnormalities.
abstract: The involvement of chromosomes 12 and 14 in uterine leiomyomas has been well established. However, in a recent report of only a del(7)(q22.1q31.32) or (q11.2q22.3) in two cases of typical uterine leiomyoma, Boghosian et al. hypothesized that this could represent a cytogenetic subgroup of uterine leiomyomas. We report a case of uterine leiomyoma with both the t(12;14) and del(7) in all the cells examined and discuss the implications of this in terms of critical chromosomal rearrangements underlying the route to benign cellular proliferation.
authors.affiliation: Cancer Center, Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
authors.forename: S N
authors.initials: SN
authors.lastname: Sait
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: S
authors.initials: S
authors.lastname: Ovanessoff
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
mesh_terms: D002872:Chromosome Deletion; D002881:Chromosomes, Human, Pair 12; D002883:Chromosomes, Human, Pair 14; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000235:genetics*; D008875:Middle Aged; D014178:Translocation, Genetic; D014594:Uterine Neoplasms / Q000235:genetics*