title: [Immunomodulation by cryosurgery in malignant melanoma].
abstract: Cryosurgery is a well-known, established method for the local destruction of tumor tissue by freezing. The assumption that, in addition to a physical and blood vascular phase, an immunological phase exists, has been discussed by many authors and tested using animal models. These results can only be transferred to humans in a limited sense. During the last year, we initiated a randomized study "Cryosurgery versus Conventional Surgery", whereby the peripheral blood and the normal skin from the areas surrounding the resection were compared. We were able to demonstrate in the peripheral blood of 8 cryosurgery patients a postoperative increase in the total and helper T-cells, HLA-DR-positive cells, and the ratio helper/suppressor T-cells in comparison to preoperative values. In the 8 patients treated with conventional surgery, these parameters decreased slightly or remained the same. The differences were highly significant (p = 0.001) to significant (p = 0.01). The results from the first 16 are patients studied presented and discussed here.
authors.affiliation: Universitätshautklinik Hamburg.
authors.forename: U
authors.initials: U
authors.lastname: Weyer
authors.forename: I
authors.initials: I
authors.lastname: Petersen
authors.forename: C
authors.initials: C
authors.lastname: Ehrke
authors.forename: A
authors.initials: A
authors.lastname: Carstensen
authors.forename: A
authors.initials: A
authors.lastname: Nüssgen
authors.forename: C
authors.initials: C
authors.lastname: Russ
authors.forename: B
authors.initials: B
authors.lastname: Göttsch
authors.forename: L
authors.initials: L
authors.lastname: Kowalzick
authors.forename: R
authors.initials: R
authors.lastname: Arndt
authors.forename: E W
authors.initials: EW
authors.lastname: Breitbart
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D003452:Cryosurgery; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D007958:Leukocyte Count; D008297:Male; D008545:Melanoma / Q000276:immunology / Q000601:surgery*; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012878:Skin Neoplasms / Q000276:immunology / Q000601:surgery*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal
vernacular_title: Immunmodulation durch Kryochirurgie beim malignen Melanom.