[Effect of kavinton on systemic and regional hemodynamics in waking and anesthetized rats].
The effect of cavinton (vinpocetine) on the systemic and regional hemodynamic parameters was studied by the radioactive microsphere technique in experiments on conscious and anesthetized rats. Intravenous administration of cavinton (10 mg/kg) was followed by the development of hypotension and bradycardia in conscious and anesthetized animals. Administration of cavinton to anesthetized rats increased the blood flow both in the brain and in most internal organs. In conscious animals the drug failed to increase the cerebral blood flow but increased the blood flow in the internal organs. It is suggested that dilation of the cerebral vessels under the influence of cavinton only in anesthetized rats could be related to a higher initial resistance of the cerebral vessels in anesthetized animals as compared with conscious ones.
Ivashev
M N
MN
Martynova
E R
ER
Medvedev
O S
OS
D000758:Anesthesia; D000818:Animals; D006328:Cardiac Catheterization; D006439:Hemodynamics / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*; D014748:Vinca Alkaloids / Q000494:pharmacology*; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C044905:nicotinoyl-GABA; C013983:vinpocetine; D005680:gamma-Aminobutyric Acid
Vliianie kavintona na sistemnuiu i regionarnuiu gemodinamiku u bodrstvuiushchikh i narkotizirovannykh krys.