Correction of blood drug levels for changes over the day.
A graph-based method is presented to compensate for the influence of variations in drug dosage schedules and blood sampling times upon the blood concentrations of drugs whose elimination half-life is between 7 and 48 hours. This method permits the clinician to interpret blood drug levels drawn at nonstandard times, and to correct blood drug levels for how the daily dose was divided. This method is expected to improve the convenience of monitoring blood drug levels.
Swartz
C M
CM
Department of Psychiatry, University of Health Sciences, Chicago Medical School, IL 60064.
D001800:Blood Specimen Collection; D006207:Half-Life; D006801:Humans; D004364:Pharmaceutical Preparations / Q000097:blood*; D013997:Time Factors
D004364:Pharmaceutical Preparations