Cell cycle traverse in NHIK-3025 carcinoma of the uterine cervix after low-dose-rate irradiation.
Theoretically, fractionation schemes could be tailored to the individual pattern of radiation-induced synchronization of cells in the radiosensitive G2 phase, leading to more effective radiotherapy. Using a human cervical carcinoma xenografted to nude mice, the effects of low-dose-rate irradiation on the cell cycle distribution were studied. Flow cytometric analysis demonstrated that cells accumulated in G2 + M phase 35 h after a total dose of 10 Gy of 137Cs irradiation. This accumulation time corresponded closely to the cell cycle time (Tc) (31 h) of this tumor, as determined by autoradiography. Further experiments are planned to determine the potential of fractionation schemes adjusted to the Tc-related accumulation in G2 in improving the effectiveness of radiotherapy.
van Oostrum
I E
IE
Institute of Radiotherapy, University Hospital Utrecht, The Netherlands.
Rutgers
D H
DH
D000818:Animals; D001918:Brachytherapy; D002453:Cell Cycle / Q000528:radiation effects*; D002588:Cesium Radioisotopes / Q000627:therapeutic use; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007399:Interphase; D051379:Mice; D008819:Mice, Nude; D008938:Mitosis; D014183:Transplantation, Heterologous; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*
D002588:Cesium Radioisotopes