Pharmacokinetic properties of sustained-release theophylline (Theolair-SR) in relation to timing of doses after low-fat meals.
Pharmacodynamic and pharmacokinetic properties of sustained-release anyhdrous theophylline (Theolair-SR) were similar when doses were given either immediately after or two hours after low-fat meals in children with moderate asthma requiring daily theophylline maintenance. Asthma and pulmonary function values were maintained and approached values for healthy subjects during both treatment regimens.
Welsh
P W
PW
Division of Allergic Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota.
O'Connell
E J
EJ
Sachs
M I
MI
Moyer
T P
TP
Wick
K A
KA
Harrison
L I
LI
McCarville
S E
SE
Kvam
D C
DC
D000293:Adolescent; D001249:Asthma / Q000188:drug therapy; D002648:Child; D003692:Delayed-Action Preparations; D004041:Dietary Fats / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D005540:Forced Expiratory Flow Rates; D005541:Forced Expiratory Volume; D005652:Functional Residual Capacity; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D004041:Dietary Fats; D013806:Theophylline