[Response to antitumoral agents of a human medulloblastoma implanted into the chorioallantoic membrane of a chick embryo].
In a previous study the authors have reported on a correlation between the effects of drugs on gliomas grown in the eggs and in the nude mice, and in this study, they have observed the antineoplastic effects of ACNU or combined chemotherapy (CAP-cyclophosphamide, adriamycin, cisplatin) against a medulloblastoma applied onto the chorioallantoic membrane (CAM) of a chick embryo. In this model, ACNU was thought to be ineffective because of an intracerebral dissemination that occurred in spite of the administration of ACNU. ACNU also proved ineffective against the medulloblastoma that grew on the CAM. There seemed to be correlation between the results of this test and the clinical course of this model. Thus this sensitivity test is thought to be useful in the screening of drugs against gliomas.
Nakamura
O
O
Dept. of Neurosurgery, Tokyo Metropolitan Komagome Hospital.
Sasaki
T
T
Tanaka
M
M
Endo
Y
Y
Tamura
A
A
Matsutani
M
M
Takakura
K
K
D000293:Adolescent; D000482:Allantois; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D002528:Cerebellar Neoplasms / Q000473:pathology* / Q000628:therapy; D002642:Chick Embryo; D002945:Cisplatin / Q000494:pharmacology; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000473:pathology* / Q000628:therapy; D009368:Neoplasm Transplantation; D015376:Nimustine / Q000494:pharmacology*
D015376:Nimustine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin