[Experimental study of Rhizoma drynariae (Gusuibu) in the treatment of streptomycin ototoxicity].
According to Chinese traditional medical theory, kidney governs ear. Gusuibu is a kind of traditional Chinese drug which has nutritive effect to the kidney. The present study was intended to show whether Gusuibu could reduce streptomycin ototoxicity. Changes in cochlear hair cells, the Preyer's reflexes and auditory brain stem responses in guinea pigs were examined. Statistical analysis showed that hair cell loss in Gusuibu group was significantly milder then that in the control group; hearing threshold was also significantly different between these two groups. It was suggested that Gusuibu may have protective effect against streptomycin ototoxicity.
Wang
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D000818:Animals; D001933:Brain Stem / Q000503:physiopathology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects*; D008297:Male; D013307:Streptomycin / Q000009:adverse effects*
D004365:Drugs, Chinese Herbal; D013307:Streptomycin