Experimental human exposure to ethylene glycol monomethyl ether.
The uptake of EGME and the urinary excretion of its major metabolite (MAA) was studied in seven male volunteers during experimental exposure to EGME at rest. The exposure concentration was set at 16 mg/m3, the present Threshold Limit Value. A high retention (0.76) remained unchanged during the 4-h exposure period. In combination with a constant pulmonary ventilation and a fixed exposure concentration this resulted in an uptake rate that showed no significant variation in time. The total amount of EGME inhaled corresponded to a dose of only 0.25 mg/kg. During and up to 120 h after the start of the exposure, MAA was detected in the urine. The elimination half-life was on average 77.1 h. The total amount of MAA excreted was calculated by extrapolation and averaged 85.5% of the inhaled EGME. The pharmacokinetic data are compared with those obtained from other human exposure studies to ethylene glycol ethers (EGEE and EGBE).
Groeseneken
D
D
Laboratory of Occupational Hygiene and Toxicology, K.U. Leuven, Belgium.
Veulemans
H
H
Masschelein
R
R
Van Vlem
E
E
D000085:Acetates / Q000652:urine*; D000328:Adult; D005026:Ethylene Glycols / Q000378:metabolism* / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D008297:Male; D012119:Respiration / Q000187:drug effects; D012997:Solvents
D000085:Acetates; D005026:Ethylene Glycols; D012997:Solvents; C013598:methoxyacetic acid; C021296:2-ethoxyethanol