Kynurenic acid antagonizes the excitatory postsynaptic potential elicited in neostriatal neurons in the in vitro slice of the rat.
Stimulation of corpus callosum in rat brain slices evoked an excitatory postsynaptic potential (EPSP) in neostriatal neurons. This EPSP is greatly reduced by exposing the slice to kynurenic acid (KY). The action of KY is reversed when the preparation is bathed in normal Ringer's solution. KY reduces the EPSP amplitude in a dose-dependent fashion, with 1 mM KY attenuating the potential by 86%. The effect is not due to a conductance change, since KY treatment does not alter the neuron's input resistance.
Walsh
J P
JP
Mental Retardation Research, UCLA School of Medicine 90024.
Hull
C D
CD
Levine
M S
MS
Buchwald
N A
NA
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003337:Corpus Callosum / Q000502:physiology*; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007736:Kynurenic Acid / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D007736:Kynurenic Acid