Hyperaluminaemia associated with oral citrate and aluminium hydroxide.
1. A hospitalized patient with renal failure receiving oral aluminium hydroxide was found to have a blood aluminium level of 3124 micrograms/l (116 mumol/l). 2. The extremely high aluminium concentration was attributed to the concurrent use of an oral citrate solution which converted the aluminium to a more soluble and absorbable form. 3. The combination of oral aluminium and citrate should be avoided in patients with poor renal function.
Kirschbaum
B B
BB
Department of Medicine, Medical College of Virginia, Richmond 23298.
Schoolwerth
A C
AC
D000284:Administration, Oral; D000535:Aluminum / Q000097:blood*; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000009:adverse effects*; D002951:Citrates / Q000008:administration & dosage / Q000009:adverse effects*; D019343:Citric Acid; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008875:Middle Aged
D002951:Citrates; D019343:Citric Acid; D000536:Aluminum Hydroxide; D000535:Aluminum