title: Myotonic dystrophy is closely linked to the gene for muscle-type creatine kinase (CKMM).
abstract: We have studied genetic linkage between the gene for creatine kinase muscle type (CKMM) and the gene for myotonic dystrophy (DM). In a panel of 65 myotonic dystrophy families from Canada and the Netherlands, a maximum lod score (Zmax) of 22.8 at a recombination frequency (theta) of 0.03 was obtained. Tight linkage was also demonstrated for CKMM and the gene for apolipoprotein C2 (ApoC2). This establishes CKMM as a useful marker for myotonic dystrophy.
authors.affiliation: Department of Human Genetics, University of Nijmegen, Radboud Hospital, The Netherlands.
authors.forename: H G
authors.initials: HG
authors.lastname: Brunner
authors.forename: R G
authors.initials: RG
authors.lastname: Korneluk
authors.forename: M
authors.initials: M
authors.lastname: Coerwinkel-Driessen
authors.forename: A
authors.initials: A
authors.lastname: MacKenzie
authors.forename: H
authors.initials: H
authors.lastname: Smeets
authors.forename: H M
authors.initials: HM
authors.lastname: Lambermon
authors.forename: B A
authors.initials: BA
authors.lastname: van Oost
authors.forename: B
authors.initials: B
authors.lastname: Wieringa
authors.forename: H H
authors.initials: HH
authors.lastname: Ropers
mesh_terms: D053304:Apolipoprotein C-II; D001056:Apolipoproteins C / Q000235:genetics; D002888:Chromosomes, Human, Pair 19; D003402:Creatine Kinase / Q000235:genetics*; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007527:Isoenzymes; D009223:Myotonic Dystrophy / Q000235:genetics*; D011995:Recombination, Genetic
chemical_list: D053304:Apolipoprotein C-II; D001056:Apolipoproteins C; D005819:Genetic Markers; D007527:Isoenzymes; D003402:Creatine Kinase