title: [Basic aspects of the preventive use of antibiotics in general surgery].
abstract: Antibiotics are administered prophylactically before operation (at induction of anesthesia) in order to achieve sufficient tissue concentrations when contamination happens. Antibiotic prophylaxis is usually given as a single dose. It is clearly indicated in abdominal surgery. It is also recognized in association with the use of prosthesis in cardiac, vascular, and bone surgery although there is no proven benefit. According to definition, administration of antibiotics in a perforated hollow viscus or an open fracture is not a prophylaxis. First and second generation cephalosporines are recommended for prophylactic use. In abdominal surgery, aminoglycosides too, combined with a drug directed against anaerobic bacteria are widely used.
authors.affiliation: Department Chirurgie, Universitätsspitals Zürich.
authors.forename: H P
authors.initials: HP
authors.lastname: Simmen
authors.forename: F
authors.initials: F
authors.lastname: Largiadèr
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000517:prevention & control*; D006801:Humans; D011292:Premedication; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Grundsätzliches zur Antibiotikaprophylaxe in der Allgemeinchirurgie.