Synthesis and biological activity of a series of piperazine-2,3-dione containing penicillins and 6 alpha-formamidopenicillins. I. Derivatives substituted at C(5) or C(6) of the piperazine ring.
The synthesis and antibacterial activity of a series of penicillins and 6 alpha-formamidopenicillins containing a C(5) or C(6)-substituted piperazine-2,3-dione moiety in the C(6)-beta-sidechain is described.
Davies
D T
DT
Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Surrey, U.K.
Harrington
F P
FP
Knott
S J
SJ
Southgate
R
R
D010406:Penicillins / Q000138:chemical synthesis* / Q000494:pharmacology; D010879:Piperazines / Q000138:chemical synthesis; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D010406:Penicillins; D010879:Piperazines