[The role of thrombocyte aggregation function in the mechanism of the antimetastatic action of an extract of Baikal skullcap].
The advancement of Pliss' lymphosarcoma in rats was shown to be associated with disorders of platelet-mediated hemostasis presenting with either lowered or increased aggregation activity of platelets. In the latter case, a direct correlation was observed between functional activity of thrombocytes, on the one hand, and degree of tumor advancement and its metastatic activity, on the other. Extract of Scutellaria baicalensis Georgi was shown to produce a normalizing effect on platelet-mediated hemostasis whatever the pattern of alteration which points to the adaptogenic activity of the drug. This activity is thought to be responsible for the drug's antitumor and, particularly, metastasis-preventing effect.
Razina
T G
TG
Udintsev
S N
SN
Tiutrin
I I
II
Borovskaia
T G
TG
Iaremenko
K V
KV
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D008207:Lymphatic Metastasis; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000188:drug therapy; D008297:Male; D009368:Neoplasm Transplantation; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
Izuchenie roli agregatsionnoĭ funktsii trombotsitov v mekhanizme protivometastaticheskogo deĭstviia ékstrakta shlemnika baĭkal'skogo.