title: [Initial symptoms of malignant thyroid tumors: the effect of age and sex in an iodine-deficient region. Experiences with 1116 patients].
abstract: Initial symptoms of thyroid cancer were collected and analysed for 1116 patients with thyroid cancer in an iodine-deficient region, retrospectively for the period 1960-80 (604 patients), prospectively for 1981-87 (512). Using the WHO classification, 56.1% of patients had papillary, 32.7% follicular, 4.8% C-cell, 3.7% anaplastic and 2.7% various other malignant tumours. In 40% of all patients the initial sign had been a solitary intrathyroid nodule. Cervical lymph node swelling as initial sign had been significantly more frequent in men (21.1%) than in women (10.3%; P less than 0.003). In patients aged under 40 years the cervical lymph node signs were three times as common as among those over 50 years. Distant metastases as initial sign of papillary carcinoma were seen only in those over 60 years. Tumour stages T3 and T4 were seen significantly more frequently in over 60-year-old (42.2%) than under 40-year-old (25.1%; P less than 0.001), independent of histological type. Composition and initial signs of this patient cohort in an iodine-deficient region differed only slightly from those in an iodine-rich region.
authors.affiliation: Abteilung für klinische Endokrinologie der Medizinischen Klinik und Poliklinik, Universitätsklinik Essen.
authors.forename: D
authors.initials: D
authors.lastname: Reinwein
authors.forename: G
authors.initials: G
authors.lastname: Benker
authors.forename: R
authors.initials: R
authors.lastname: Windeck
authors.forename: F W
authors.initials: FW
authors.lastname: Eigler
authors.forename: L D
authors.initials: LD
authors.lastname: Leder
authors.forename: M L
authors.initials: ML
authors.lastname: Mlynek
authors.forename: H
authors.initials: H
authors.lastname: Creutzig
authors.forename: C
authors.initials: C
authors.lastname: Reiners
mesh_terms: D000367:Age Factors; D004197:Disease Reservoirs; D005260:Female; D005860:Germany, West; D006801:Humans; D007455:Iodine / Q000172:deficiency*; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging; D011446:Prospective Studies; D012189:Retrospective Studies; D012737:Sex Factors; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology
chemical_list: D007455:Iodine
vernacular_title: Erstsymptome bei Schilddrüsenmalignomen: Einfluss von Alter und Geschlecht in einem Jodmangelgebiet. Erfahrungen an 1116 Patienten.