Heterotopic neurons in spinal cord of patients with ALS.
Monoclonal antibody 44.1, an immunocytochemical marker for neurons, identified heterotopically located, multipolar neurons deep within the spinal cord white matter of patients with amyotrophic lateral sclerosis. Displaced neurons were most numerous in the ventral outflow and lateral corticospinal tract regions of all cord levels. These changes may be the result of aberrant neuronal migration during spinal cord development.
Kozlowski
M A
MA
Department of Pathology, University of Southern California School of Medicine, Los Angeles 90033.
Williams
C
C
Hinton
D R
DR
Miller
C A
CA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology*; D000911:Antibodies, Monoclonal; D006801:Humans; D008875:Middle Aged; D009046:Motor Neurons / Q000254:growth & development; D009474:Neurons / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology*
D000911:Antibodies, Monoclonal