A prospective randomized trial of schedules for sclerosing esophageal varices. 1-versus 2-week intervals.
A prospective randomized trial was performed to compare the efficacy and complications of 1-week (20 patients) and 2-week (20 patients) interval schedules of endoscopic injection sclerotherapy for patients with esophageal varices; 6 were acute, 3 were elective and 31 were prophylactic cases. There were no significant differences between the 1-week and 2-week interval groups with regard to total number of sclerotherapy sessions, total volume of the sclerosant used (5% ethanolamine oleate) or rate of complications such as pyrexia, stricture and pleural effusion. The incidence of ulcer and/or slough formation after EIS was the same in the two groups. Neither early nor recurrent bleeding occurred in any patient in the two groups. Eradication of varices in the 2-week interval group was achieved significantly earlier (p less than 0.05) than in the 1-week interval group.
Higashi
H
H
Department of Surgery II, Kyushu University, Faculty of Medicine, Fukuoka, Japan.
Kitano
S
S
Hashizume
M
M
Yamaga
H
H
Sugimachi
K
K
D000208:Acute Disease; D004334:Drug Administration Schedule; D004932:Esophageal and Gastric Varices / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012597:Sclerosing Solutions / Q000008:administration & dosage; D015911:Sclerotherapy; D013997:Time Factors
D012597:Sclerosing Solutions