[Effect of the antitumor preparations prospidin and spirobromin on the function of the liver lysosomal apparatus in mice].
Antitumour drugs prospidine and spirobromine were shown to suppress the activity of the mouse liver lysosome enzymes in vivo and in experiments in vitro. The revealed effect was underlied by a decrease of lysosomal membrane permeability for the corresponding substrates and enzymes rather than a reduction of the catalytic activity of acid hydrolases.
Kliment'eva
T K
TK
Sal'nik
B Iu
BIu
Chamina
G M
GM
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D003902:Detergents / Q000493:pharmacokinetics / Q000494:pharmacology; D006867:Hydrolases / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D017830:Octoxynol; D010879:Piperazines / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000493:pharmacokinetics / Q000494:pharmacology; D011447:Prospidium / Q000493:pharmacokinetics / Q000494:pharmacology*; D013141:Spiro Compounds / Q000493:pharmacokinetics / Q000494:pharmacology*
D000970:Antineoplastic Agents; D003902:Detergents; D010879:Piperazines; D013141:Spiro Compounds; D011092:Polyethylene Glycols; D011447:Prospidium; C054863:spirobromin; D017830:Octoxynol; D006867:Hydrolases
Vliianie protivoopukholevykh preparatov prospidina i spirobromina na sostoianie lizosomal'nogo apparata pecheni mysheĭ.