The Mlvi-1 locus involved in the induction of rat T-cell lymphomas and the pvt-1/Mis-1 locus are identical.
Mlvi-1 defines a locus of proviral integration in rat thymomas induced by Moloney murine leukemia virus. pvt-1/Mis-1 represents an independently identified locus which becomes rearranged either by chromosomal translocation in murine plasmacytomas or by provirus insertion in retrovirus-induced murine and rat thymic lymphomas. Although it had been claimed that pvt-1/Mis-1 and Mlvi-1 represent two different loci, we present here evidence showing that they are identical. This finding demonstrates the need for rigorous characterization of any newly identified common regions of integration in retrovirus-induced neoplasms.
Koehne
C F
CF
Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Lazo
P A
PA
Alves
K
K
Lee
J S
JS
Tsichlis
P N
PN
O'Donnell
P V
PV
D000818:Animals; D015139:Blotting, Southern; D002472:Cell Transformation, Viral; D002874:Chromosome Mapping; D015342:DNA Probes; D008223:Lymphoma / Q000235:genetics* / Q000382:microbiology; D051379:Mice; D008979:Moloney murine leukemia virus / Q000235:genetics*; D051381:Rats; D012045:Regulatory Sequences, Nucleic Acid; D015183:Restriction Mapping; D013945:Thymoma / Q000235:genetics* / Q000382:microbiology
D015342:DNA Probes