[Characteristics of the normal gluconeogenesis effect of prostaglandin F2 alpha and in myocardial infarct].
The effect of PGF2 alpha on glucose synthesis de novo in a healthy rat organism and those with coronary occlusion-myocardial infarction was studied. There was observed prostaglandin's metabolic action simultaneously at one direction: there was increased the concentration of non-nitric precursors of gluconeogenesis in blood of animals of both groups, final disintegration product of tissue proteins, the gluconeogenic activity of key enzymes and therefore the concentration of newly formed glucose went up as so as glycogen in liver, cardiac and skeletal muscle. Seemingly, PGF2 alpha stimulates the intensity not only of gluco-, but glyconeogenesis having cardioprotective action. At the same time metabolic effect of PGF2 alpha is strongly marked in coronary occlusion rat with myocardial infarction.
Blinov
V A
VA
Minnulina
N R
NR
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D015237:Dinoprost / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005943:Gluconeogenesis / Q000187:drug effects*; D007672:Kidney Cortex / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D001786:Blood Glucose; D015237:Dinoprost
Kharakteristika gliukoneogennogo éffekta prostaglandina F2 al'fa v norme i pri infarkte miokarda.