title: Ascorbic acid absorption in Crohn's disease. Studies using L-[carboxyl-14C]ascorbic acid.
abstract: Total body pool and intestinal absorption of ascorbic acid were studied in 12 patients undergoing operation for Crohn's disease (six with fistulae and six without) and in six control patients undergoing operation for reasons other than Crohn's disease. L-[carboxyl-14C]Ascorbic acid, 0.19-0.40 megabecquerels (MBq), was given orally. After a period of equilibration, the labeled ascorbic acid was flushed out of the patient's body tissues using large doses of unlabeled ascorbic acid. Intestinal absorption of ascorbic acid, assessed from the total cumulative urinary 14C recovery, was found to be similar in patients with fistulizing Crohn's disease (73.9 +/- 8.45%), those without fistulas (72.8 +/- 11.53%), and in controls (80.3 +/- 8.11%). Total body pools of ascorbic acid, calculated using the plasma 14C decay curves, were similar in patients with Crohn's disease with fistulas (17.1 +/- 5.91 mg/kg), patients without fistulas (9.6 +/- 3.58 mg/kg), and in controls (13.3 +/- 4.28 mg/kg). The results indicate that ascorbic acid absorption is normal in patients with both fistulizing and nonfistulizing Crohn's disease. The results suggest that routine supplements of vitamin C are not necessary unless oral ascorbic acid intake is low.
authors.affiliation: Department of Surgery, Hope Hospital, University of Manchester School of Medicine, Salford, United Kingdom.
authors.forename: S H
authors.initials: SH
authors.lastname: Pettit
authors.forename: J L
authors.initials: JL
authors.lastname: Shaffer
authors.forename: C W
authors.initials: CW
authors.lastname: Johns
authors.forename: R J
authors.initials: RJ
authors.lastname: Bennett
authors.forename: M H
authors.initials: MH
authors.lastname: Irving
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000378:metabolism*; D002250:Carbon Radioisotopes; D003424:Crohn Disease / Q000150:complications / Q000378:metabolism*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007412:Intestinal Fistula / Q000209:etiology / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D002250:Carbon Radioisotopes; D001205:Ascorbic Acid