title: Cell-mediated and humoral immune responses in mice during experimental infection with Mycoplasma pulmonis.
abstract: Cell-mediated and humoral immune responses in mice after challenge exposure with Mycoplasma pulmonis were investigated. The cell-mediated immune response was determined by means of the delayed-type footpad swelling and the humoral immune response by means of the indirect haemagglutination test. Delayed-type footpad swelling and serum antibody titres were detected at one week after the challenge exposure and persisted for 7 weeks until the end of the experiment. However, there was a poor correlation between the degree of delayed-type footpad swelling and that of serum antibody titre. Delayed-type footpad swelling in mice with gross pneumonic lesions was less than that of mice with no gross lesions. A weak negative linear correlation was observed between the delayed-type footpad swelling and the number of M. pulmonis isolated from lungs.
authors.affiliation: Hokkaido Branch Laboratory, National Institute of Animal Health, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kishima
authors.forename: C
authors.initials: C
authors.lastname: Kuniyasu
authors.forename: M
authors.initials: M
authors.lastname: Eguchi
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial; D006386:Hemagglutination Tests; D006968:Hypersensitivity, Delayed / Q000276:immunology / Q000382:microbiology; D007111:Immunity, Cellular; D008168:Lung / Q000473:pathology; D009174:Mycoplasma / Q000302:isolation & purification; D009175:Mycoplasma Infections / Q000209:etiology / Q000276:immunology* / Q000382:microbiology; D011014:Pneumonia / Q000276:immunology / Q000382:microbiology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial