title: Effect of renal failure on the pharmacokinetics of ethyl loflazepate (Victan) in man.
abstract: The kinetics of ethyl loflazepate were studied in patients with various degrees of renal failure. A strong correlation was noted between urinary excretion of metabolite loflazepate and creatinine clearance. In contrast, elimination half-life and total plasma clearance of the sum of loflazepate + descarboxyloflazepate seemed to be independent of the degree of renal impairment. These results indicate the absence of a risk of accumulation of the 2 main and active metabolites of ethyl loflazepate in patients with renal failure.
authors.affiliation: INSERM U 278, Faculté de Pharmacie, Marseille, France.
authors.forename: B B
authors.initials: BB
authors.lastname: Ba
authors.forename: A
authors.initials: A
authors.lastname: Iliadis
authors.forename: A
authors.initials: A
authors.lastname: Durand
authors.forename: Y
authors.initials: Y
authors.lastname: Berger
authors.forename: J
authors.initials: J
authors.lastname: Necciari
authors.forename: J P
authors.initials: JP
authors.lastname: Cano
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C029617:ethyl loflazepate