title: Noradrenaline turnover in brown adipose tissue and the heart of fed and fasted golden hamsters.
abstract: The effect of fasting on sympathetic activity in tissues of the golden hamster has been investigated using measurements of noradrenaline turnover. Fasting for 60 h did not have a significant effect on noradrenaline turnover, both fractional and total, in brown adipose tissue or the heart. Fasting did, however, result in a functional atrophy of brown adipose tissue; tissue weight, protein content, and cytochrome oxidase activity were each reduced after a 60-h fast. These results suggest that the atrophy of brown adipose tissue induced by fasting in the golden hamster does not relate to a major decrease in sympathetic activity. The findings add further support for the view that the thermogenic capacity of brown adipose tissue is not primarily dependent on sympathetic activity in the golden hamster.
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Trayhurn
authors.forename: A
authors.initials: A
authors.lastname: Howe
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D001835:Body Weight; D006224:Cricetinae; D005215:Fasting; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D013997:Time Factors
chemical_list: D009638:Norepinephrine