title: Interovarian relationship in the secretion of progesterone during the luteal phase of the capuchin monkey (Cebus apella).
abstract: In basal conditions, progesterone concentrations were similar in the ovarian veins of the ovary +CL (3211 +/- 526 ng/ml) and the ovary -CL (3165 +/- 554 ng/ml), but after blocking the blood flow between the ovary +CL and the uterus, the progesterone values in the vein draining the ovary -CL decreased to 1218 +/- 394 ng/ml (P less than 0.01). When [3H]progesterone was injected in the ovary +CL, the radioactivity appeared earlier and more concentrated in the vein draining the ovary -CL (30 sec, 0.53% of injected dose) than in the femoral vein (150 sec, 0.08% of injected dose). Removal of the ovary +CL was followed by a brief maintenance of peripheral progesterone within luteal-phase levels. The in-vitro progesterone production by a suspension of cells isolated from the corpus luteum was 47.5 +/- 12.8 ng/ml/2 h, whereas luteal-like cells isolated from the ovary -CL secreted 14.3 +/- 6.0 ng/ml/2 h (P less than 0.01) into the medium. We therefore suggest that the symmetrical and high secretion rate of progesterone by the ovaries of the capuchin monkey indicates a between-ovary communication system, and that the luteal-like tissue of the ovary -CL can produce relatively large amounts of progesterone.
authors.affiliation: Centro de Investigaciones en Reproducción Humana y Experimental, Buenos Aires, Argentina.
authors.forename: C A
authors.initials: CA
authors.lastname: Nagle
authors.forename: N
authors.initials: N
authors.lastname: Paul
authors.forename: I
authors.initials: I
authors.lastname: Mazzoni
authors.forename: S
authors.initials: S
authors.lastname: Quiroga
authors.forename: M
authors.initials: M
authors.lastname: Torres
authors.forename: A F
authors.initials: AF
authors.lastname: Mendizabal
authors.forename: Z
authors.initials: Z
authors.lastname: Farinati
mesh_terms: D000818:Animals; D002428:Cebus; D002478:Cells, Cultured; D005260:Female; D008184:Luteal Cells / Q000378:metabolism; D008183:Luteal Phase; D010053:Ovary / Q000098:blood supply / Q000378:metabolism*; D011374:Progesterone / Q000097:blood / Q000378:metabolism*
chemical_list: D011374:Progesterone