title: Cytogenetic analysis of metastatic effusions from breast tumors.
abstract: Chromosome analysis was performed on direct and in vitro cultures of 30 effusions from breast carcinoma. Although in 14 samples normal diploid stem-lines were found, chromosome abnormalities were present in stem- or side-lines of all cases. Recurrent numerical deviations were only verified as gains of Nos. 6 and 7. Rearrangements were seen involving almost all chromosome pairs (except No. 18 and gonosomes), however, Nos. 1, 3, 6 and 11 were those most frequently related to the genesis of markers. Double minutes (DMs) were found in seven samples, and there was a homogeneously staining region (HSR) in one.
authors.affiliation: Department of Genetics, Fundacion Jiménez Díaz, Madrid, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Bello
authors.forename: J A
authors.initials: JA
authors.lastname: Rey
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations / Q000453:epidemiology*; D025063:Chromosome Disorders; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002893:Chromosomes, Human, Pair 3; D002896:Chromosomes, Human, Pair 6; D005122:Exudates and Transudates / Q000166:cytology; D005260:Female; D006801:Humans; D007621:Karyotyping; D009362:Neoplasm Metastasis; D011003:Ploidies