[Synthesis and antimalarial as well as antitumor activities of 1-methyl-2,4-diamino-6-(N-methyl-substituted benzylamion) quinazolinium iodides].
Fourteen 1-methyl-2,4-diamino-6-(N-methyl-substituted benzylamino) quinazolinium iodides (II) were synthesized by treatment of 2,4-diamino-6-substituted benzylaminoquinazolines with methyl iodide. Three compounds (II4,7,10) were shown to produce 100% suppression on Plasmodium berghei in mice at oral dose of 20 mg/kg and II4 was found to inhibit twice as much as methotrexate on L1210 Leukemia cells in culture.
Zhou
W C
WC
Xin
Z M
ZM
Li
B S
BS
Li
G D
GD
Zhang
X P
XP
D000818:Animals; D000962:Antimalarials; D000970:Antineoplastic Agents; D001596:Benzylamines / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003959:Diamines / Q000138:chemical synthesis* / Q000494:pharmacology; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D010962:Plasmodium berghei / Q000187:drug effects; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000962:Antimalarials; D000970:Antineoplastic Agents; D001596:Benzylamines; D003959:Diamines; D011799:Quinazolines