title: Hypercholesterolaemia in treated hypertensives: a controlled trial of intensive dietary advice.
abstract: We evaluated dietary counselling by dietitians in hypercholesterolaemic hypertensives over 6 months. A total of 141 patients were randomly assigned to intensive advice or usual care. Body weight fell significantly in the intervention group, but did not in the controls. There was a modest but significant fall in total cholesterol from 7.1 to 6.8 and 7.1 to 6.9 mmol/l in the diet and the control groups, respectively (4 and 3%). A similar pattern emerged from the triglyceride measurements. Low-density lipoprotein fell in both groups, but only achieved significance (P less than 0.05) in the intervention group. High-density lipoprotein did not change. There was a more marked change in cholesterol when serum levels during the study were compared with the previous annual review. These falls occurred after selection for the study but before random allocation to groups. They are unlikely to reflect regression to the mean as the lipids were stable for 2 or more years before the study, but may reflect spontaneous changes in diet after the patients were labelled hypercholesterolaemic. Dietary advice can lower total cholesterol but the magnitude of this decrease is small. Additional approaches are likely to be required to reduce plasma cholesterol to a normal range.
authors.affiliation: Department of Materia Medica, University of Glasgow, UK.
authors.forename: J L
authors.initials: JL
authors.lastname: Curzio
authors.forename: S S
authors.initials: SS
authors.lastname: Kennedy
authors.forename: H L
authors.initials: HL
authors.lastname: Elliott
authors.forename: E
authors.initials: E
authors.lastname: Farish
authors.forename: J F
authors.initials: JF
authors.lastname: Barnes
authors.forename: C A
authors.initials: CA
authors.lastname: Howie
authors.forename: J
authors.initials: J
authors.lastname: Seymour
authors.forename: J L
authors.initials: JL
authors.lastname: Reid
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D003131:Combined Modality Therapy; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy*; D006973:Hypertension / Q000097:blood / Q000178:diet therapy*; D008074:Lipoproteins / Q000097:blood; D016032:Randomized Controlled Trials as Topic; D014280:Triglycerides / Q000097:blood
chemical_list: D000959:Antihypertensive Agents; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol