Plasma nitrendipine concentrations in elderly normotensive volunteers after single and multiple dosing.
An acute and chronic dosing pharmacokinetic study of the calcium antagonist nitrendipine was carried out in 8 normotensive volunteers (mean age 80.1 +/- 3.4 years) to investigate if drug accumulation occurred in the elderly. Subjects received 10 mg nitrendipine once daily by mouth for 8 days. Plasma nitrendipine concentrations before administration and at 0.5, 1, 2, 4, 6 and 8 hours after dosing were measured after the first and last dose. Comparison of the pharmacokinetic data from Days 1 and 8 failed to show any evidence of nitrendipine accumulation in these elderly subjects.
Crome
P
P
Orpington Hospital, Orpington, England.
Baksi
A
A
Edwards
J
J
Marley
J
J
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D009568:Nitrendipine / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
D009568:Nitrendipine