[Characteristics of the differentiation of hematopoietic stem cells of the bone marrow in experimental lesions of the liver].
The liver lesion in the CBA mice has been induced by administration of one of three agents five times every day; gamma-globulin fraction of antihepatocytotoxic serum in doses of 4.8 and 7.7 mg of protein per 100 g of body mass; gamma-globulin fraction of normal rabbit serum and bovine serum albumin in a dose of 4.8 mg of protein; three- four- or five-fold introduction of carbon tetrachloride in a dose of 0.5 ml per 100 g of body mass with oil (1:1) each three days; calibrated stenosis of the portal vein was produced. The total number of hemopoietic stem cells in the bone marrow was estimated by the colony-forming unit/spleen assay. Histological analysis of the colony-forming units was applied. The liver lesion was accompanied by a decrease in the ratio of the erythroid/granulocytic colonies.
Alekseeva
I N
IN
Pavlovich
S I
SI
D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology*; D002454:Cell Differentiation / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D051379:Mice; D008808:Mice, Inbred CBA
Osobennosti differentsirovki stvolovykh krovetvornykh kletok kostnogo mozga pri eksperimental'nykh porazheniiakh pecheni.