cis-beta-acetylacrylate is a substrate for maleylacetoacetate cis-trans isomerase. Mechanistic implications.
Maleylacetoacetate cis-trans isomerase together with coenzyme glutathione catalyzes cis-trans isomerization of cis-beta-acetylacrylate strongly suggesting that the isomerase directly catalyzes isomerization of the diketo forms in addition to the ketoenol forms of maleylacetone and maleylacetoacetate. The isomerase exhibits wider substrate acceptance than previously thought.
Lee
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HE
Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973.
Seltzer
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D005229:Fatty Acids, Monounsaturated / Q000378:metabolism*; D007535:Isomerases / Q000378:metabolism*; D007700:Kinetics; D013379:Substrate Specificity; D019745:cis-trans-Isomerases
D005229:Fatty Acids, Monounsaturated; C059576:4-oxo-2-pentenoic acid; D007535:Isomerases; D019745:cis-trans-Isomerases; C021531:maleylacetoacetate isomerase