Diffuse storage of vegetal wax hydrocarbons of dietary origin. Pathologic and chemical findings in a case.
A 55-year-old man died suddenly, after presenting with unstable angina and an asymptomatic micronodular pulmonary pattern. Autopsy revealed storage of a crystallized fatty substance in the lymph nodes, liver, spleen, adrenal glands, and lungs. In the latter organ, the deposition formed foreign body granulomas, accounting for the radiographic appearance. Mass spectrometry identified the fatty substance as straight-chain saturated hydrocarbons (n-alkanes) of carbon-29 and carbon-31 atoms, which are naturally present in the cuticular wax of many vegetals. The case history and the elimination as causal agent of products manipulated in the patient's work led to the conclusion that the storage was due to excessive consumption of apples, and to a lesser degree of Brussels sprouts. We present the light-microscopic findings and the principal biochemical results. Pathogenic mechanisms are described. As far as we are aware, this is the only observation of vegetal alkane storage to be described to date.
Duboucher
C
C
Department of Pathology, CHU Rangueil, Toulouse, France.
Rocchiccioli
F
F
Lageron
A
A
Nègre
A
A
Salvayre
R
R
Bouissou
H
H
D005547:Foreign Bodies / Q000150:complications / Q000473:pathology; D005602:France; D005638:Fruit / Q000009:adverse effects* / Q000032:analysis; D006099:Granuloma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D006838:Hydrocarbons / Q000009:adverse effects / Q000378:metabolism*; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014018:Tissue Distribution; D014675:Vegetables / Q000009:adverse effects / Q000032:analysis; D014885:Waxes / Q000009:adverse effects / Q000378:metabolism*
D006838:Hydrocarbons; D014885:Waxes