title: Aminopyrine-N-demethylase activity of rat liver after administration of crude cannabis extract.
abstract: The effect of cannabis extract, on the hepatic aminopyrine-N-demethylase activity was studied in rats. Daily administration of cannabis extract for 15 consecutive days increased the aminopyrine-N-demethylase activity which was significant on day 15 post-treatment at 2 and 10 mg/kg doses. At 20 mg/kg, a significant increase was observed from day 7 which continued up to day 15. These findings suggest that cannabis extract can induce hepatic aminopyrine-N-demethylase activity.
authors.forename: N
authors.initials: N
authors.lastname: Sethi
authors.forename: P K
authors.initials: PK
authors.lastname: Agnihotri
authors.forename: S
authors.initials: S
authors.lastname: Srivastava
mesh_terms: D000633:Aminopyrine N-Demethylase / Q000096:biosynthesis*; D000818:Animals; D002186:Cannabinoids / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D051381:Rats
chemical_list: D002186:Cannabinoids; D000633:Aminopyrine N-Demethylase