title: Spinal cord blood flow measured by 14C-iodoantipyrine autoradiography during and after graded spinal cord compression in rats.
abstract: The relations between degree of thoracic spinal cord compression causing myelographic block, reversible paraparesis, and extinction of the sensory evoked potential on one hand, and spinal cord blood flow on the other, were investigated. This was done in rats using the blocking weight-technique and 14C-iodoantipyrine autoradiography. A load of 9 g caused myelographic block. Five minutes of compression with that load caused a reduction of spinal cord blood flow to about 25%, but 5 and 60 minutes after the compression spinal cord blood flow was restored to 60% of the pretrauma value. A load of 35 g for 5 minutes caused transient paraparesis. Recovery to about 30% was observed 5 and 60 minutes thereafter. During compression at a load of 55 g, which caused almost total extinction of sensory evoked potential and irreversible paraplegia, spinal cord blood flow under the load ceased. The results indicate that myelographic block occurs at a load which does not cause irreversible paraparesis and that a load which permits sensory evoked potential to be elicited results in potentially salvageable damage.
authors.affiliation: Department of Neurosurgery, University Hospital, Uppsala, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Holtz
authors.forename: B
authors.initials: B
authors.lastname: Nyström
authors.forename: B
authors.initials: B
authors.lastname: Gerdin
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives*; D001345:Autoradiography; D001794:Blood Pressure; D002250:Carbon Radioisotopes; D008297:Male; D009192:Myelography; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D013116:Spinal Cord / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology; D013117:Spinal Cord Compression / Q000503:physiopathology*
chemical_list: D002250:Carbon Radioisotopes; D000983:Antipyrine; C008135:iodoantipyrine