title: A new operation for the prevention and treatment of amputation neuromas.
abstract: A stump neuroma is caused by the disorganised growth of axon cylinders into proliferating granulation tissue, but this is stopped by an undamaged epineural sleeve. We report experiments in the rat in which the epineural sleeve of the stump of the sciatic nerve was freed from nerve fascicles for about 5 mm and then sealed with a synthetic tissue adhesive. Neuroma formation was largely prevented in comparison with the results of other methods. This new technique has been used to treat 68 painful neuromas in 36 patients. All but three of the patients were cured or improved and none were made worse.
authors.affiliation: Department of Hand Surgery, Orthopaedic University Hospital, Heidelberg, West Germany.
authors.forename: A
authors.initials: A
authors.lastname: Martini
authors.forename: B
authors.initials: B
authors.lastname: Fromm
mesh_terms: D000671:Amputation, Surgical / Q000379:methods*; D000818:Animals; D003238:Connective Tissue / Q000601:surgery / Q000648:ultrastructure; D004659:Enbucrilate / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D009412:Nerve Fibers / Q000648:ultrastructure; D009463:Neuroma / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000601:surgery*; D014014:Tissue Adhesives / Q000627:therapeutic use*
chemical_list: D014014:Tissue Adhesives; D004659:Enbucrilate