title: Effect of naproxen on renal haemodynamics in elderly patients with arthritis.
abstract: The effects of naproxen on renal haemodynamics were observed in ten elderly arthritic patients who were otherwise healthy and without clinical evidence of renal disease. Glomerular filtration rate (GFR,51Cr-EDTA clearance) and effective renal plasma flow (ERPF, 125I-iodohippurate clearance) were measured after 2 weeks' treatment with naproxen 500 mg twice daily and again after 2 weeks off the drug, in random order. Baseline values for GFR and ERPF were within normal limits (mean 72 ml/min/1.73 m2, 110% predicted and 326 ml/min/1.73 m2, 111% predicted, respectively). On naproxen, ERPF and renal blood flow decreased by 10% and 9%, respectively (-32 ml/min/1.73 m2; p = 0.05 and -49 ml/min/1.73 m2; p less than 0.01). These events produced no untoward clinical effects. Nevertheless, this response might impair the kidney's ability to preserve GFR if a further stress were to supervene. Consequently, temporary withdrawal of non-steroidal anti-inflammatory drugs from elderly patients should be considered in response to intercurrent illness or drug therapy likely to compromise renal blood flow.
authors.affiliation: Department of Geriatric Medicine, East Birmingham Hospital.
authors.forename: P J
authors.initials: PJ
authors.lastname: Wallis
authors.forename: R
authors.initials: R
authors.lastname: Lodwick
authors.forename: S K
authors.initials: SK
authors.lastname: Sinha
authors.forename: T J
authors.initials: TJ
authors.lastname: Constable
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D009288:Naproxen / Q000009:adverse effects / Q000494:pharmacology*; D010003:Osteoarthritis / Q000188:drug therapy / Q000503:physiopathology*; D011897:Random Allocation; D012079:Renal Circulation / Q000187:drug effects*
chemical_list: D009288:Naproxen