Neuropeptides and neural cell adhesion molecule (NCAM) in CSF from patients with ALS.
In 10 patients with amyotrophic lateral sclerosis (ALS), the CSF content of the neuropeptides vasoactive intestinal polypeptide (VIP) and cholecystokinin (CCK) as well as neural cell adhesion molecule (NCAM) was investigated. Compared with normal controls, no deviations were found in CCK or NCAM, while the values of VIP were significantly lower in ALS patients. This finding may reflect a loss of motor neurons.
Werdelin
L
L
Department of Neurology, Righospitalet, Copenhagen, Denmark.
Gjerris
A
A
Boysen
G
G
Fahrenkrug
J
J
Jørgensen
O S
OS
Rehfeld
J F
JF
D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000134:cerebrospinal fluid*; D000954:Antigens, Surface / Q000134:cerebrospinal fluid*; D010244:Bulbar Palsy, Progressive / Q000134:cerebrospinal fluid; D015815:Cell Adhesion Molecules; D002766:Cholecystokinin / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009133:Muscular Atrophy / Q000134:cerebrospinal fluid; D014660:Vasoactive Intestinal Peptide / Q000134:cerebrospinal fluid
D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D014660:Vasoactive Intestinal Peptide; D002766:Cholecystokinin