[Cellular electrolyte metabolism and regulation of vascular tonus. Clinical aspects].
In the pathogenesis of essential hypertension the role of intracellular Na+ concentrations due to the secretion of a yet unidentified natriuretic factor is being discussed. Proceeding from the role of Ca++ in vascular smooth muscle contraction the hypothesis of increased intracellular free Ca++ concentrations in essential hypertension has been proposed. The measurements described here first revealed increased cellular concentrations of free Ca++ in essential hypertensives. Furthermore in essential hypertensives and in the spontaneously hypertensive rat a circulating factor was demonstrated increasing blood pressure and stimulating cellular Ca++ uptake.
Zidek
W
W
Medizinische Universitäts-Poliklinik, Münster/Westf.
D000818:Animals; D004573:Electrolytes / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology*; D009129:Muscle Tonus; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D009318:Natriuresis; D051381:Rats; D012964:Sodium / Q000378:metabolism
D004573:Electrolytes; D012964:Sodium
Zellulärer Elektrolythaushalt und Regulation des Gefässtonus. Klinische Aspekte.