Solitary midbrain toxoplasmosis and olivary hypertrophy in a patient with acquired immunodeficiency syndrome.
Toxoplasmosis, one of the most common central nervous system lesions in patients with the acquired immunodeficiency syndrome (AIDS), has not been reported as a solitary lesion in the brainstem. This report describes a patient with AIDS that presented with third cranial nerve palsy and contralateral cerebellar signs, who at autopsy had a necrotic midbrain lesion due to toxoplasma. Inferior olivary hypertrophy, due to interruption of olivary afferent fibers by the lesion, in addition to subacute encephalitis and vacuolar myelopathy were other CNS findings.
Kure
K
K
Department of Pathology (Neuropathology) Albert Einstein College of Medicine, Bronx, NY 10461.
Harris
C
C
Morin
L S
LS
Dickson
D W
DW
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology*; D000328:Adult; D001927:Brain Diseases / Q000150:complications / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D006801:Humans; D006984:Hypertrophy; D008297:Male; D008636:Mesencephalon / Q000473:pathology*; D009336:Necrosis; D009474:Neurons / Q000648:ultrastructure; D009847:Olivary Nucleus / Q000473:pathology*; D009894:Opportunistic Infections / Q000150:complications / Q000473:pathology*; D014123:Toxoplasmosis / Q000150:complications / Q000473:pathology*