[Drug-induced priapism--a report of experiences in 101 cases].
Within a period of 3 1/2 years, 101 patients with drug-induced priapism lasting more than 6 h were observed. In 73 of the 101 patients (average age 47.4 years) with an average duration of priapism of 11.9 h priapism was interrupted by means including cavernosal puncture, evacuation, and injection of metaraminol. In 28 patients priapism subsided after an average duration of 8.8 h without medical intervention. Intracavernous blood gas analyses revealed unphysiological acid values with clearly negative excess base values. Nevertheless, in the present series only 3 patients had irreversible damage of cavernosal function as a sequela of priapism of more than 24 h duration. Intracavernosal injection of meta-ramininol was followed by severe hypertensive crisis in 2 patients. These results show convincingly that the demand for early interruption of drug-induced priapism within a time limit of 6 h is not based on objective necessity. Interruption of drug-induced priapism within 6-8 h seems to be adequate. Prostaglandin E1 has proved a reliable means of preventing priapism in the initial test period.
Porst
H
H
Urologische Abteilung, Allgemeines Krankenhaus Harburg, Hamburg.
van Ahlen
H
H
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D007267:Injections; D008297:Male; D008680:Metaraminol / Q000008:administration & dosage; D008875:Middle Aged; D010208:Papaverine / Q000009:adverse effects*; D010646:Phentolamine / Q000009:adverse effects*; D011317:Priapism / Q000139:chemically induced* / Q000188:drug therapy
D008680:Metaraminol; D010208:Papaverine; D010646:Phentolamine
Pharmakon-induzierte Priapismen--ein Erfahrungsbericht über 101 Fälle.