Influence of food on bioavailability from two controlled-release granules of theophylline.
The bioavailability and absorption pattern of theophylline from Theolong granule and Theodur-G were studied in five healthy volunteers both in fasting conditions and after taking two different meals. In all the subjects, no dose-dumping effect was observed with a standard- or a fat-rich breakfast on these preparations. Postprandial administration delayed the absorption of theophylline and a fat-rich breakfast significantly reduced the area under the curve (AUC0-26) for both preparations. The mean AUC decreased by 14.0% for the former and 19.7% for the latter when the fat-rich breakfast was administered. Intake of a standard breakfast resulted in a decrease in the AUC0-26 by 10.6% for Theolong granules but there was little effect observed with the Theodur-G granules.
Tada
H
H
Department of Pharmaceutical Science, Akita University Hospital, Japan.
Ishikawa
M
M
Sato
E
E
Suzuki
T
T
Unno
K
K
Miura
K
K
Ohmiya
Y
Y
Nakai
K
K
D000328:Adult; D001682:Biological Availability; D003692:Delayed-Action Preparations; D005260:Female; D005502:Food; D006207:Half-Life; D006801:Humans; D008297:Male; D012995:Solubility; D013806:Theophylline / Q000008:administration & dosage / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D013806:Theophylline