[A multicenter randomized study of fusidic acid ophthalmic gel and rifamycine eyedrops in acute conjunctivitis].
A total of 163 patients with acute, presumably bacterial, conjunctivitis were included in a randomized trial, comparing: 1% fusidic acid viscous eye drops, a new ophthalmic formulation of fusidic acid instilled twice daily with rifamycin eye drops, four times daily. Both drugs were given 7 days long. Bacterial origin of the conjunctivitis, mainly staphylococcal, was proved in 75% of the cases. Overall, at the end of the treatment, a satisfactory response, on bacteriological and clinical grounds, was recorded for 87.3 and 89.5% of the patients in the Fucidin gel and rifamycin groups respectively. 9 and 12% of the patients in each group respectively, had a clinical recurrence 15 days after the treatment. No significant difference between the groups clinically and bacteriologically was noted. Side effects, mainly burning and smarting were noted by the investigators in 8 and 11 patients treated by fusilic acid and rifamycin respectively. Two patients were taken out of the study in the rifamycin group because of allergy. The difference between the groups is not significant. The use of fusidic acid viscous eye drops as compared to rifamycin eye drops was judged significantly easier by the patients (P less than 0.02), especially because of the reduced number of applications, the lack of color, and the lase of application.
Adenis
J P
JP
Centre hospitalier universitaire, Limoges.
Arrata
M
M
Gastaud
P
P
Limon
S
S
Massin
M
M
D000208:Acute Disease; D000328:Adult; D000368:Aged; D003234:Conjunctivitis, Bacterial / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D005672:Fusidic Acid / Q000627:therapeutic use*; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009883:Ophthalmic Solutions; D016032:Randomized Controlled Trials as Topic; D012294:Rifamycins / Q000627:therapeutic use*
D005782:Gels; D009883:Ophthalmic Solutions; D012294:Rifamycins; D005672:Fusidic Acid
Etude randomisée multicentrique acide fusidique gel ophtalmique et rifamycine collyre dans les conjonctivites aiguës.