title: The association of posterior capsular lens opacities with bilateral acoustic neuromas in patients with neurofibromatosis type 2.
abstract: This study of 47 patients from 11 families with neurofibromatosis type 2 (NF 2) confirms our previously reported association between posterior capsular cataract and NF 2. A highly significant statistical association was found between the presence of posterior capsular lens opacities and the presence of NF 2 as determined by magnetic resonance imaging or pathologic diagnosis. This association was not present for other types of lens opacities that could be the result of age-related or nonspecific changes. When considering the diagnosis of NF 2, this finding now makes it essential to use a careful dilated biomicroscopic examination of the lens to evaluate known, suspected, or at-risk individuals for this potentially early associated manifestation.
authors.affiliation: Clinical Branch, National Eye Institute, Bethesda, MD 20892.
authors.forename: M I
authors.initials: MI
authors.lastname: Kaiser-Kupfer
authors.forename: V
authors.initials: V
authors.lastname: Freidlin
authors.forename: M B
authors.initials: MB
authors.lastname: Datiles
authors.forename: P A
authors.initials: PA
authors.lastname: Edwards
authors.forename: J L
authors.initials: JL
authors.lastname: Sherman
authors.forename: D
authors.initials: D
authors.lastname: Parry
authors.forename: L M
authors.initials: LM
authors.lastname: McCain
authors.forename: R
authors.initials: R
authors.lastname: Eldridge
mesh_terms: D002386:Cataract / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009464:Neuroma, Acoustic / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D010375:Pedigree; D010781:Photography