title: Haloperidol reduction can be assayed in human red blood cells.
abstract: One metabolite of haloperidol present in plasma is "reduced haloperidol." This study demonstrates that human red blood cells are capable of converting haloperidol to reduced haloperidol in vitro. The reductase involved requires NADPH, as does haloperidol (ketone) reductase in human liver cytosol.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, University of Toronto, Ont., Canada.
authors.forename: T
authors.initials: T
authors.lastname: Inaba
authors.forename: W
authors.initials: W
authors.lastname: Kalow
authors.forename: T
authors.initials: T
authors.lastname: Someya
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: S W
authors.initials: SW
authors.lastname: Cheung
authors.forename: S W
authors.initials: SW
authors.lastname: Tang
mesh_terms: D000328:Adult; D000429:Alcohol Oxidoreductases / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D006220:Haloperidol / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008297:Male; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction
chemical_list: D009249:NADP; D000429:Alcohol Oxidoreductases; C063466:haloperidol reductase; D006220:Haloperidol