Assessment of the biological stability of human thyroid stimulating hormone prepared by immunoaffinity chromatography.
This paper reports a comprehensive study of the biological stability of an immunoaffinity purified preparation of human thyroid stimulating hormone (TSH) and provides a reference against which future natural or synthetic preparations may be compared. The stability of the hormone preparation was investigated using the accelerated degradation method. The bioassay of the TSH was carried out in mice using a modified McKenzie method. Analysis of the results showed that the preparation was as stable as other TSH preparations purified by conventional methods.
Blazek
R W
RW
Public Health Laboratory Service, Centre for Applied Microbiology and Research, Salisbury, UK.
Randles
S C
SC
D000818:Animals; D002846:Chromatography, Affinity; D004355:Drug Stability; D051379:Mice; D008807:Mice, Inbred BALB C; D011863:Radioimmunoassay; D013696:Temperature; D013972:Thyrotropin / Q000032:analysis* / Q000276:immunology
D013972:Thyrotropin