title: [Insulin--its past, present and future].
abstract: Since the invention of insulin and further, the numerous research workers have been trying to get the hormone in the most possible purest form and to make it more convenient for the treatment. By gel-filtration and ion-exchange chromatography can be obtained maximum purified insulin the so-called monocomponent insulin which possesses considerably less antigen characteristics than the conventional insulins. The human insulins obtained by semisynthesis and biosynthesis through genetic engineering the further progress in the treatment of diabetes mellitus by insulin. The intensified insulin therapy is applied nowadays by repeated injections of insulin, through application of insulin pumps in the so-called open systems and by application of artificial pancreas in the so-called closed systems. The complete normalization of glycemia can be achieved only by means of the closed system and that is the system which would work at the principle of glucose-insulin feed back. Unfortunately, these devices are very big and their use for nowadays in everyday practice is not possible yet.
authors.forename: M
authors.initials: M
authors.lastname: Grujić
authors.forename: Z
authors.initials: Z
authors.lastname: Hrisafović
authors.forename: I
authors.initials: I
authors.lastname: Kulenović
mesh_terms: D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use
chemical_list: D007328:Insulin
vernacular_title: Insulin--njegova proslost, sadasnjost i budućnost.