Use of telemetry to record body temperature and activity in mice.
A complete, commercially available, integrated telemetry and data acquisition system is described, which is used to record core temperature and activity in mice. The system is comprised of a telemetry transmitter (implanted in the peritoneal cavity), a receiver (placed underneath the cage) connected to a computer with software (Dataquest), which converts the transmitter signals directly into core temperature and activity. The information is stored on either a floppy diskette or a hard disk in the computer. The effects of anesthesia (sodium pentobarbital, halothane), handling, aggregation, restraint, a cholinergic agonist (oxotremorine), and an anticholinesterase agent, soman (pinacolyl methylphosphonofluoridate), on core temperature and activity were examined. The telemetry system for the recording of core temperature and activity provides a more accurate assessment of the temporal effects of various drugs and is more efficient and less labor intensive than the use of a rectal temperature probe.
Clement
J G
JG
Biomedical Defence Section, Defence Research Establishment Suffield, Ralston, Alberta, Canada.
Mills
P
P
Brockway
B
B
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010095:Oxotremorine / Q000494:pharmacology; D012149:Restraint, Physical; D012919:Social Behavior; D012999:Soman / Q000494:pharmacology; D013686:Telemetry / Q000295:instrumentation*
D010095:Oxotremorine; D012999:Soman