title: Susceptibility of Plasmodium falciparum strains to chloroquine and mefloquine in the Amazonas Federal Territory of Venezuela.
abstract: The susceptibilities of 27 Plasmodium falciparum strains to chloroquine and mefloquine were studied in the area of Puerto Ayacucho, Amazonas Federal Territory of Venezuela, to determine their levels of resistance in vivo and in vitro. 50% of these strains showed chloroquine resistance in vivo. No grade III chloroquine resistance was found. 25% of the strains were resistant to chloroquine in vitro and 9% were resistant to mefloquine in vitro. Preliminary results suggest that strains resistant to Fansidar may also be found.
authors.affiliation: Laboratoire d'Hématologie, Centre Hospitalier Universitaire du Bocage, Dijon, France.
authors.forename: M
authors.initials: M
authors.lastname: Maynadié
authors.forename: C
authors.initials: C
authors.lastname: Peceño
authors.forename: P L
authors.initials: PL
authors.lastname: Noriega
authors.forename: L
authors.initials: L
authors.lastname: Yarzabal
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000494:pharmacology* / Q000627:therapeutic use; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D015767:Mefloquine / Q000494:pharmacology* / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects*; D014687:Venezuela
chemical_list: D002738:Chloroquine; D015767:Mefloquine