[Various indicators of brain metabolism during hypoxia and hyperthermia].
Hypoxic, thermal and radiation tolerance of rats exposed to hypoxia and overheating for 4 to 22 days was measured. Activities of succinic dehydrogenase, lactate dehydrogenase and alkaline phosphomonoesterase as well as water content in the brain were examined biochemically and histochemically. Brain tolerance and metabolism varied in a phasic manner. Both specific and nonspecific adaptive reactions were identified. A direct correlation was established between hypoxic tolerance and aerobic oxidation decrease as well as enzyme-dependent transport in cerebral vascular walls. A relationship between CNS radiation tolerance and permeability of the blood-brain barrier was detected.
Razinkin
S M
SM
Kordenko
A N
AN
Ushakov
I B
IB
Dukhovich
V M
VM
D000222:Adaptation, Physiological / Q000528:radiation effects; D000469:Alkaline Phosphatase / Q000378:metabolism / Q000528:radiation effects; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000528:radiation effects; D003037:Cobalt Radioisotopes / Q000008:administration & dosage*; D005260:Female; D006358:Hot Temperature; D002534:Hypoxia, Brain / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism / Q000528:radiation effects; D011836:Radiation Tolerance; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism / Q000528:radiation effects
D003037:Cobalt Radioisotopes; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000469:Alkaline Phosphatase
Nekotorye pokazateli metabolizma v golovnom mozge pri gipoksii i perenagrevanii.