Irritable bowel syndrome: therapeutic evaluation of indigenous drugs.
Among 169 patients with irritable bowel syndrome (IBS), standard therapy (with clidinium bromide, chlordiazepoxide and isaphaghulla), a compound Ayurvedic preparation (with Aegle marmelos correa plus Bacopa monniere Linn) along with a matching placebo were given in a double blind randomised trial for 6 wk. The Ayurvedic preparation in 57 patients was found effective in 64.9 per cent, while standard therapy (60 patients) was useful in 78.3 per cent. Patients on placebo (52 patients) showed improvement in 32.7 per cent only. Ayurvedic therapy was particularly beneficial in diarrhoea predominant form as compared to placebo. The standard therapy was more useful in the painful form of IBS as compared to placebo and Ayurvedic preparation. In gas predominant form the effect of standard as well as Ayurvedic therapy, was similar to placebo. Long-term follow-up (greater than 6 months) showed that both forms of therapy were no better than placebo in limiting the relapse.
Yadav
S K
SK
Jain
A K
AK
Tripathi
S N
SN
Gupta
J P
JP
D000293:Adolescent; D000328:Adult; D002707:Chlordiazepoxide / Q000627:therapeutic use*; D003109:Colonic Diseases, Functional / Q000188:drug therapy*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008515:Medicine, Ayurvedic; D008875:Middle Aged; D010946:Plants, Medicinal; D011812:Quinuclidines / Q000627:therapeutic use*; D011813:Quinuclidinyl Benzilate / Q000031:analogs & derivatives / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
D011812:Quinuclidines; C100256:clidinium compounds; D011813:Quinuclidinyl Benzilate; D002707:Chlordiazepoxide