Effects of prednisolone and dexamethasone on (pro)insulin biosynthesis and insulin release by rat islets of Langerhans.
Administration of either prednisolone or dexamethasone (10 mg/kg body wt/day/oral) to rats for 21 days resulted in inhibition of (pro)insulin biosynthesis and immunoreactive insulin release by isolated islets. A gradual reversal of prednisolone's effect was obtained after exposing islets to increasing glucose concentrations but glucose challenges failed to influence dexamethasone's effect.
Chandrasekar
B
B
Mukherjee
S K
SK
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011239:Prednisolone / Q000494:pharmacology*; D011384:Proinsulin / Q000096:biosynthesis*; D051381:Rats
D007328:Insulin; D003907:Dexamethasone; D011384:Proinsulin; D011239:Prednisolone