title: cis-beta-acetylacrylate is a substrate for maleylacetoacetate cis-trans isomerase. Mechanistic implications.
abstract: Maleylacetoacetate cis-trans isomerase together with coenzyme glutathione catalyzes cis-trans isomerization of cis-beta-acetylacrylate strongly suggesting that the isomerase directly catalyzes isomerization of the diketo forms in addition to the ketoenol forms of maleylacetone and maleylacetoacetate. The isomerase exhibits wider substrate acceptance than previously thought.
authors.affiliation: Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973.
authors.forename: H E
authors.initials: HE
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Seltzer
mesh_terms: D005229:Fatty Acids, Monounsaturated / Q000378:metabolism*; D007535:Isomerases / Q000378:metabolism*; D007700:Kinetics; D013379:Substrate Specificity; D019745:cis-trans-Isomerases
chemical_list: D005229:Fatty Acids, Monounsaturated; C059576:4-oxo-2-pentenoic acid; D007535:Isomerases; D019745:cis-trans-Isomerases; C021531:maleylacetoacetate isomerase