[Cortisol contents in maternal and umbilical artery blood during delivery of low birth weight fetuses].
Cortisol was measured in 50 parturients with low birthweight (LBW) fetuses in the course of vaginal delivery (n-18) and cesarean section (n-32). Twenty normal parturients whose pregnancy and labor were uncomplicated were taken as controls. In the main group, low birthweights corresponded to gestational age in 30 parturients, and fetal growth retardation (FGR) was diagnosed in 20. In the course of vaginal delivery, maternal cortisol level increased significantly, the rise being higher in parturients with the FGR syndrome. In both groups, blood cortisol levels were higher in the umbilical artery as compared to umbilical vein; in FGR cases, umbilical-artery cortisol level approached the respective values in control newborns. Following cesarean section, LBW fetuses showed considerably lower umbilical cortisol levels. Separate examination of cortisol fractions has demonstrated that free cortisol goes up in the maternal blood both at vaginal and abdominal delivery. The effect of corticosteroids, used to prevent respiratory distress syndrome, on maternal adrenal activity and LBW fetuses has been evaluated.
Chernukha
E A
EA
Komissarova
L M
LM
Malysheva
V A
VA
Abubakirova
A M
AM
Galstian
A A
AA
D000328:Adult; D002585:Cesarean Section; D036861:Delivery, Obstetric; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D005317:Fetal Growth Retardation / Q000175:diagnosis*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011247:Pregnancy; D014469:Umbilical Arteries; D014471:Umbilical Veins
D006854:Hydrocortisone
Soderzhanie kortizola v materinskoĭ i pupovinnoĭ krovi pri rodorazreshenii zhenshchin s malovesnymi plodami.