title: [Specific and non-specific contrast media for MRI of tumors. Experimental study of human breast carcinoma].
abstract: MRI has been shown as an adapted non-invasive modality for the detection of tumours in humans. The development of paramagnetic contrast agents could add to the MRI diagnosis. With an experimental model of human breast (MX-1) carcinoma developed in nude mice, two different classes of contrast medium were tested. The first class includes the well-known Gd-DTPA and a new nitroxide compound on going development, representing non specific contrast agents. The specific contrast agents are represented by a metalloporphyrin Mn-TPPS4. Non specific contrast agents can add to the differentiation between well vascularized viable tissue and necrotic areas of tumors. While specific contrast agents may specifically target tumorous tissue.
authors.affiliation: Hôpital Cardio-Vasculaire et Pneumologique, Service de Radiologie, Lyon Montchat.
authors.forename: D
authors.initials: D
authors.lastname: Revel
authors.forename: M
authors.initials: M
authors.lastname: Ogan
authors.forename: H
authors.initials: H
authors.lastname: Paajanen
authors.forename: W
authors.initials: W
authors.lastname: Grodd
authors.forename: W
authors.initials: W
authors.lastname: Couet
authors.forename: W
authors.initials: W
authors.lastname: Rosenau
authors.forename: R C
authors.initials: RC
authors.lastname: Brasch
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D003497:Cyclic N-Oxides; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D008665:Metalloporphyrins; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009374:Neoplasms, Experimental; D009928:Organ Specificity; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011166:Porphyrins; D013997:Time Factors
chemical_list: D003287:Contrast Media; D003497:Cyclic N-Oxides; D008665:Metalloporphyrins; D009942:Organometallic Compounds; D011166:Porphyrins; D004369:Pentetic Acid; C056661:manganese(III)tetraphenylporphine sulfonate; C050028:N-1-hydroxymethyl-2,3-dihydroxypropyl-2,2,5,5-tetramethylpyrrolidin-1-oxyl-3-carboxamide; D019786:Gadolinium DTPA
vernacular_title: Produits de contraste non spécifiques et spécifiques pour l'imagerie par résonance magnétique (I.R.M.) des tumeurs. Etude expérimentale d'un carcinome mammaire humain.