In vitro evaluation of ampicillin-gentamicin interactions.
Ampicillin at a concentration of 100 micrograms/mL was combined in vitro with either gentamicin 10 micrograms/mL in serum, 0.01 mol/L phosphate-buffered saline at 37 degrees C, or water at room temperature (25 degrees C). At these concentrations, which represent the peak prophylactic serum concentrations likely to be achieved by a 70-kg person after parenteral administration of 1.5 mg/kg gentamicin and 2 g of ampicillin, no clinically significant inactivating effects of these antibiotics on each other were observed over a period of six hours.
Van der Bijl
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P
Department of Oral Medicine and Periodontics, Faculty of Dentistry, University of Stellenbosch, Tygerberg, South Africa.
Seifart
H I
HI
D000667:Ampicillin / Q000032:analysis / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D005839:Gentamicins / Q000032:analysis / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D013696:Temperature
D005839:Gentamicins; D000667:Ampicillin