title: Rate-controlled rectal absorption enhancement of cefoxitin by co-administration of sodium salicylate or sodium octanoate in healthy volunteers.
abstract: 1. The effects of sodium octanoate and sodium salicylate on the rectal absorption of cefoxitin were investigated in healthy volunteers. Drug solutions were given either as a bolus or as a zero-order infusion. 2. On rectal infusion sodium octanoate and sodium salicylate both enhanced mean cefoxitin bioavailability (+/- s.d.) from 5.0 +/- 1.2% to 9.1 +/- 1.3% and 9.2 +/- 1.5%, respectively. After rectal bolus delivery octanoate increased the mean cefoxitin bioavailability from 7 +/- 3% to 17 +/- 3%, whereas bolus salicylate did not produce a statistically significant effect. All formulations were well tolerated by the volunteers. 3. It is concluded that both octanoate and salicylate are capable of enhancing rectal cefoxitin absorption in man; rate of delivery seems to be an important factor.
authors.affiliation: Division of Pharmacology, Sylvius Laboratories, State University of Leiden, The Netherlands.
authors.forename: E J
authors.initials: EJ
authors.lastname: Van Hoogdalem
authors.forename: A T
authors.initials: AT
authors.lastname: Wackwitz
authors.forename: A G
authors.initials: AG
authors.lastname: De Boer
authors.forename: A F
authors.initials: AF
authors.lastname: Cohen
authors.forename: D D
authors.initials: DD
authors.lastname: Breimer
mesh_terms: D000042:Absorption; D000285:Administration, Rectal; D000328:Adult; D001682:Biological Availability; D002210:Caprylates / Q000008:administration & dosage* / Q000494:pharmacology; D002440:Cefoxitin / Q000493:pharmacokinetics*; D004357:Drug Synergism; D006801:Humans; D008297:Male; D012007:Rectum / Q000378:metabolism*; D012016:Reference Values; D012980:Sodium Salicylate / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D002210:Caprylates; D002440:Cefoxitin; C031492:octanoic acid; D012980:Sodium Salicylate