title: Single dose safety, tolerance, and pharmacokinetics of HP 029 in healthy young men: a potential Alzheimer agent.
abstract: 1,2,3,4-tetrahydro-9-aminoacridin-1-ol maleate (HP 029) is a new cholinergic compound that has been shown to enhance memory in animals and therefore may be potentially effective in humans for the treatment of Alzheimer's disease (AD). The initial safety, tolerance, and pharmacokinetics of HP 029 after single oral doses were assessed in a randomized, double-blind, placebo controlled study in 70 healthy young men (eight dose groups). The test doses ranged from 5 to 200 mg. There were 9 subjects per dose group, 6 on HP 029 and 3 on placebo. The 5 and 100 mg dose groups had only 8 subjects. Plasma and urine samples were analyzed for nonconjugated HP 029 using an HPLC assay with a detection limit of 1 ng/ml. HP 029 was rapidly absorbed after oral dosing with mean peak plasma levels occurring between 0.75 and 1.2 hours. The mean peak levels ranged from 12.7 and 234.7 ng/ml after the 10 and 200 mg doses, respectively. There were dose related increases in peak plasma levels, AUCs, and the amounts of drug excreted in the urine. The mean plasma half-life was about 2.0 hours and was not affected by dose. About 6 to 11% of the dose was eliminated in the urine. HP 029 was renally cleared at a high rate and independent of dose. There were no clinically important or drug-related changes in any of the physical examinations, audiograms, or ophthalmologic examinations. There were only minor within-subject fluctuations in vital signs, ECGs, and laboratory values, none of which were clinically meaningful or drug related after any of the doses of HP 029.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Clinical Pharmacology Section, Hoechst-Roussel Pharmaceuticals Inc., Somerville, NJ 08876.
authors.forename: S K
authors.initials: SK
authors.lastname: Puri
authors.forename: R S
authors.initials: RS
authors.lastname: Hsu
authors.forename: I
authors.initials: I
authors.lastname: Ho
authors.forename: H B
authors.initials: HB
authors.lastname: Lassman
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000188:drug therapy*; D000609:Aminoacridines / Q000493:pharmacokinetics*; D004311:Double-Blind Method; D004341:Drug Evaluation; D004361:Drug Tolerance; D006801:Humans; D008297:Male; D011897:Random Allocation; D012307:Risk Factors; D013619:Tacrine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives / Q000493:pharmacokinetics*
chemical_list: D000609:Aminoacridines; D013619:Tacrine; C056424:velnacrine