Healing of necrobiotic ulcers with antiplatelet therapy. Correlation with plasma thromboxane levels.
Necrobiosis lipoidica in diabetics has been considered to be a cutaneous manifestation of diabetic microangiopathy. Seven diabetic patients with necrobiotic ulcers of recent onset that healed after administration of acetylsalicylic acid and dipyridamole had elevated thromboxane levels. Healing was associated with depression of the elevated thromboxane levels in all seven patients.
Heng
M C
MC
Department of Medicine, Veterans Administration Medical Center, Sepulveda, California 91343.
Song
M K
MK
Heng
M K
MK
D000328:Adult; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use*; D001792:Blood Platelets / Q000502:physiology; D004176:Dipyridamole / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009335:Necrobiosis Lipoidica / Q000097:blood / Q000188:drug therapy*; D011863:Radioimmunoassay; D013929:Thromboxane B2 / Q000097:blood*
D013929:Thromboxane B2; D004176:Dipyridamole; D001241:Aspirin