Transcription in vaccinia virus.
Transcription of poxvirus genes is temporally regulated and takes place in the cytoplasm of the infected cell. Virus-encoded enzymes produce capped, methylated and polyadenylated mRNA. The virus transcriptional apparatus recognises promoter sequences within the virus genome which bear little resemblance to either eukaryotic or prokaryotic promoter regions. mRNA's produced late in infection possess 5'poly (A) sequences which are not encoded in the genome. The process of transcription in poxviruses is reviewed using vaccinia virus as the prototype.
Kent
R
R
Department of Pathology, University of Cambridge, U.K.
D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics*; D015967:Gene Expression Regulation, Viral; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic / Q000502:physiology*; D014616:Vaccinia virus / Q000235:genetics*
D004279:DNA, Viral