title: Carrageenan-induced acute inflammatory response in chicks.
abstract: Carrageenan from two commercial sources was used in varying concentrations to evoke an acute inflammatory response in the foot pad of chickens. Oedema formation and increased vascular permeability were less severe using this experimental model than with turpentine-induced injury. Inflammation was monophasic, of short duration and apparently mediated by histamine and serotonin as their respective antagonists diminished the response. Prostaglandins seemed to play only a minor role as indomethacin blocked only the later phase of oedema. Bothrops jararaca venom did not potentiate the inflammatory response, implying that bradykinin was not a significant mediator.
authors.affiliation: Faculdade de Medicina Veterinária e Zootecnica da USP, Departamento de Patologia-Ornitopatologia, Sao Paulo, Brazil.
authors.forename: N M
authors.initials: NM
authors.lastname: Ito
authors.forename: A M
authors.initials: AM
authors.lastname: Noronha
authors.forename: G M
authors.initials: GM
authors.lastname: Bohm
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D002351:Carrageenan; D002645:Chickens; D003435:Crotalid Venoms / Q000494:pharmacology; D004487:Edema / Q000662:veterinary; D007249:Inflammation / Q000503:physiopathology / Q000662:veterinary*; D011201:Poultry Diseases / Q000503:physiopathology; D013997:Time Factors
chemical_list: D003435:Crotalid Venoms; C030961:botrocetin; D002351:Carrageenan