[Alpha-tocopherol protection of erythrocytes from hemolysis induced by thermal injury].
It is shown that skin burn is accompanied by activation of lipid peroxidation (accumulation of TBA-reactive substances and of fluorescent end-products) in the blood of experimental animals. The decrease in red blood cell membrane stability was demonstrated exerting as increase in the rate of spontaneous hemolysis, content of extraerythrocyte++ haemoglobin and increased sensitivity to exogenous oleic acid. It is estimated that alpha-tocopherol possesses protective stabilizing effect on red blood cell membrane. This stabilizing action is observed when alpha-tocopherol was injected both before the skin burn and immediately after it. It is concluded that two different mechanisms are responsible for stabilizing effect of tocopherol, namely: 1) antiradical, realized via inhibition of lipid peroxidation, and 2) non-antioxidant, caused by interaction of tocopherol with phospholipid hydrolysis products by phospholipases A2 (free fatty acids and lysophospholipids).
Bekiarova
G I
GI
Markova
M P
MP
Kagan
V G
VG
D000818:Animals; D002056:Burns / Q000097:blood / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009829:Oleic Acids / Q000494:pharmacology; D010741:Phospholipases A / Q000097:blood; D010743:Phospholipids / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000627:therapeutic use*
D009829:Oleic Acids; D010743:Phospholipids; D014810:Vitamin E; D008315:Malondialdehyde; D010741:Phospholipases A
Zashchita al'fa-tokoferolom éritrotsitov ot gemoliza, indutsirovannogo termicheskoĭ travmoĭ.