title: [Airway responsiveness measured by body plethysmograph connecting a circuit of an inhalation system of serially concentrated bronchoconstrictant].
abstract: We developed a new methodology to examine the bronchial response to the bronchoconstrictants, acetylcholine and methacholine. An inhalation device was connected to the body plethysmograph circuit so that a minute inhalation of serially concentrated bronchoconstrictant could be quickly switched to the circuit of the measurement of the airway resistance. The following were calculated: airway responsiveness in terms of sensitivity, provocative dose to increase the airway resistance up to 35% from the baseline. PC35 or PD35 and the reactivity, the slope of the declining specific airway conductance and %delta SGaw. The airway responsiveness was examined in asthmatics, COPD outgrew -childhood asthma patients and normal subjects. These three groups were categorised differently from each other in both sensitivity and reactivity.
authors.forename: Y
authors.initials: Y
authors.lastname: Uno-Komase
authors.forename: S
authors.initials: S
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Kudo
authors.forename: Y
authors.initials: Y
authors.lastname: Sano
authors.forename: J
authors.initials: J
authors.lastname: Kabe
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage; D000280:Administration, Inhalation; D000403:Airway Resistance; D001249:Asthma / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects* / Q000503:physiopathology; D001985:Bronchial Provocation Tests / Q000379:methods; D002648:Child; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000008:administration & dosage; D009330:Nebulizers and Vaporizers; D010993:Plethysmography, Whole Body
chemical_list: D008688:Methacholine Compounds; D016210:Methacholine Chloride; D000109:Acetylcholine