Action of a semi-synthetic human insulin preparation (30/70 NPH insulin Organon): comparison with another 30/70 NPH (Actraphane Novo).
The action of a new semi-synthetic insulin preparation (30% soluble, 70% NPH insulin from Organon Laboratories Eragny sur Epte France) was studied in 6 healthy male volunteers using the euglycemic clamp technique (Biostator GCIIS) and compared with another 30/70 NPH (Actraphane Novo). Insulin levels, inhibition of C peptide secretion and glucose consumption were determined. There was a time lag between the maximum glucose need (167 +/- 18 mg/Kg/15 min at the 195th minute after the injection) and the peak plasma insulin level (98.3 +/- 8.5 uu/ml at the 105th minute following the injection). The maximum glucose need was followed by a slow fall in insulin levels with a duration of action of 17 hours. The total glucose need was the same as for Actraphane, although Actraphane had a slower action with a lower peak glucose need (144 +/- 18 mg/Kg/15 min at the 280th minute after injection). The two preparations had the same duration of action.
Gin
H
H
Clinique Médicale et des Maladies Infectieuses, Hôpital Pellegrin, Bordeaux.
Nivet
A M
AM
Morlat
P
P
Aubertin
J
J
D001786:Blood Glucose / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000097:blood; D007336:Insulin, Isophane / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D011863:Radioimmunoassay; D013997:Time Factors
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D007336:Insulin, Isophane