title: Complex formation between metronidazole and sodium urate: effect on photodegradation of metronidazole.
abstract: Photodegradation of solutions of metronidazole in the presence and absence of sodium urate was studied. Photodegradation appeared to follow zero-order kinetics and was found to be dependent on the pH, buffer species, sodium urate concentration, and light source. Complex formation between metronidazole and sodium urate accounted for the photostabilization of metronidazole. The dissociation constant for this complex was calculated to be 3.4 x 10(-3) M.
authors.affiliation: College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee 32307.
authors.forename: M J
authors.initials: MJ
authors.lastname: Habib
authors.forename: A F
authors.initials: AF
authors.lastname: Asker
mesh_terms: D000935:Antifungal Agents / Q000493:pharmacokinetics*; D004355:Drug Stability; D008795:Metronidazole / Q000493:pharmacokinetics*; D010775:Photic Stimulation; D014527:Uric Acid / Q000493:pharmacokinetics*
chemical_list: D000935:Antifungal Agents; D008795:Metronidazole; D014527:Uric Acid