title: Inhaled terbutaline administered via a spacer fully prevents exercise-induced asthma in young asthmatic subjects: a double-blind, randomized, placebo-controlled study.
abstract: The effects of inhaled terbutaline, a beta 2-adrenergic agonist, administered via a 750-ml spacer device were studied in young asthmatic subjects with exercise-induced asthma. A double-blind, randomized, placebo-controlled study of the effects of inhaled 0.5 mg terbutaline and placebo was conducted in 10 asthmatic children (age range 6-16 years) with documented exercise-induced asthma. Forced expiratory volume in 1 s (FEV1) was measured at baseline, 15 min after inhaling terbutaline or placebo, and at intervals up to 60 min after exercising. Subjects exercised using a cycle ergometer for 5 min at a submaximal, constant work-load while breathing dry air at room temperature. Terbutaline induced bronchodilation at rest in all subject and fully prevented exercise-induced asthma in nine out of the 10 subjects; the exercise-induced fall in FEV1 was markedly reduced in the remaining subject. It is concluded that exercise-induced asthma can be inhibited by pretreatment with inhaled terbutaline, administered via a spacer, in a majority of young asthmatics.
authors.affiliation: Laboratoire d'Explorations Fonctionnelles Respiratoires, Hôpital St Vincent de Paul, Paris, France.
authors.forename: A T
authors.initials: AT
authors.lastname: Dinh Xuan
authors.forename: C
authors.initials: C
authors.lastname: Lebeau
authors.forename: R
authors.initials: R
authors.lastname: Roche
authors.forename: A
authors.initials: A
authors.lastname: Ferriere
authors.forename: M
authors.initials: M
authors.lastname: Chaussain
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D001249:Asthma / Q000188:drug therapy*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy*; D002648:Child; D003627:Data Interpretation, Statistical; D004311:Double-Blind Method; D004867:Equipment Design; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D009330:Nebulizers and Vaporizers; D016032:Randomized Controlled Trials as Topic; D013726:Terbutaline / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D013726:Terbutaline