Comparative in vitro activities of six new fluoroquinolones and other oral antimicrobial agents against Campylobacter pylori.
The in vitro susceptibilities of 56 clinical isolates of Campylobacter pylori to six new fluoroquinolones and other oral antimicrobial agents were determined by an agar dilution technique. Ciprofloxacin was the most active of the fluoroquinolones (MIC for 90% of strains tested [MIC90], 0.05 microgram/ml). Other fluoroquinolones had variable activities, although most isolates were moderately susceptible to fleroxacin (MIC90, 4 micrograms/ml) and lomefloxacin (MIC90, 4 micrograms/ml).
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Department of Microbiology, Mount Sinai Hospital, University of Toronto, Ontario, Canada.
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D000667:Ampicillin / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002167:Campylobacter / Q000187:drug effects*; D002939:Ciprofloxacin / Q000494:pharmacology; D015169:Colony Count, Microbial; D004917:Erythromycin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009582:Nitrofurantoin / Q000494:pharmacology; D013420:Sulfamethoxazole / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D004917:Erythromycin; D000667:Ampicillin; D009582:Nitrofurantoin; D014295:Trimethoprim; D013752:Tetracycline; D013420:Sulfamethoxazole