Genetic and immunopathological findings in a lymphoma family.
We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin's lymphoma, while a granddaughter had Hodgkin's disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3 level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.
Lynch
H T
HT
Department of Preventive Medicine/Public Health, Creighton University School of Medicine, Omaha, NE 68178.
Marcus
J N
JN
Weisenburger
D D
DD
Watson
P
P
Fitzsimmons
M L
ML
Grierson
H
H
Smith
D M
DM
Lynch
J
J
Purtilo
D
D
D000328:Adult; D000368:Aged; D005190:Family; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008213:Lymphocyte Activation; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D010375:Pedigree
D007074:Immunoglobulin G