title: Estimating the superiority of a drug to a placebo when all and only those patients at risk are treated with the drug.
abstract: It is shown that, under certain assumptions, one can estimate the difference between the effect of a treatment and that of a placebo even when the treatment has been given to all and only those patients who are at risk (as evidenced by a screening examination).
authors.affiliation: Department of Statistics, Rutgers University, New Brunswick, NJ 08903.
authors.forename: H
authors.initials: H
authors.lastname: Robbins
authors.forename: C H
authors.initials: CH
authors.lastname: Zhang
mesh_terms: D004358:Drug Therapy; D006801:Humans; D008433:Mathematics; D010919:Placebos; D012307:Risk Factors
chemical_list: D010919:Placebos