Estimating the superiority of a drug to a placebo when all and only those patients at risk are treated with the drug.
It is shown that, under certain assumptions, one can estimate the difference between the effect of a treatment and that of a placebo even when the treatment has been given to all and only those patients who are at risk (as evidenced by a screening examination).
Robbins
H
H
Department of Statistics, Rutgers University, New Brunswick, NJ 08903.
Zhang
C H
CH
D004358:Drug Therapy; D006801:Humans; D008433:Mathematics; D010919:Placebos; D012307:Risk Factors
D010919:Placebos