Adenosine-induced respiratory and heart rate changes in young and elderly adults.
The effects of intravenous boluses of adenosine on respiration and heart rate were compared in young and elderly individuals. Respiratory stimulation and biphasic changes in heart rate were confirmed. The dose-response relationship for the effects of adenosine on respiration and heart-rate did not differ significantly between 10 young (mean age 25.2 +/- 4.9 years) and 10 elderly (mean age 66 +/- 3.1 years) drug-free individuals, indicating that age is unlikely to be a major determinant of adenosine responsiveness.
Watt
A H
AH
Department of Pharmacology, University of Wales College of Medicine, Heath Park, Cardiff.
Bayer
A
A
Routledge
P A
PA
Swift
C G
CG
D000241:Adenosine / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D012119:Respiration / Q000187:drug effects*
D000241:Adenosine