Short-term effect of captopril and nifedipine on micro-albuminuria induced by exercise in hypertensive diabetic patients.
Physical exercise can induce micro-albuminuria, a urinary albumin excretion rate of 20-200 micrograms/min, in diabetics without micro-albuminuria at rest (stage II of diabetic nephropathy). The aim of the present study was to evaluate the acute effects of captopril, an angiotensin converting enzyme (ACE) inhibitor, and nifedipine, a calcium channel blocker, on exercise-induced micro-albuminuria in hypertensive diabetics with stage II nephropathy. Eleven hypertensive World Health Organisation (WHO) stages I-II non-obese diabetics (five insulin-dependent diabetics, six non-insulin dependent diabetics) underwent five submaximal cycloergometric tests, the first two in basal conditions, the other three after 24-h administration of captopril (25 mg twice a day), placebo (1 tablet twice a day) or nifedipine AR (20 mg twice a day) according to a randomized double-blind design. Our results demonstrate that despite a lower reduction in exercise blood pressure, captopril is more effective than nifedipine in blunting diabetic exercise-induced micro-albuminuria.
Romanelli
G
G
Cattedra di Patologia Speciale Medica, University of Brescia, Italy.
Giustina
A
A
Agabiti-Rosei
E
E
Bossoni
S
S
Girelli
A
A
Muiesan
M L
ML
Muiesan
G
G
Giustina
G
G
D000419:Albuminuria / Q000188:drug therapy* / Q000209:etiology / Q000652:urine; D002216:Captopril / Q000627:therapeutic use*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000188:drug therapy* / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000652:urine; D004341:Drug Evaluation; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000652:urine; D009543:Nifedipine / Q000627:therapeutic use*
D002216:Captopril; D009543:Nifedipine