title: [Alizapride in upper digestive endoscopy. A double-blind study vs metoclopramide and placebo].
abstract: In order to assess the antiemetic properties of alizapride in the specific context of premedication for endoscopy, a double blind test was conducted on 100 patients against both metoclopramide and a placebo. Efficacy was assessed on the basis of the following parameters: technical judgement of the endoscopist; assessment of evident signs of "discomfort" by an outside observer; comparative judgement (better, worse, same) of the patient's condition after the two endoscopies performed. In the case of the first two parameters, alizapride proved significantly more effective than the control substances. The patients themselves only expressed a significant preference for alizapride vis-à-vis the placebo. It is concluded that given its efficacy and the absence of side effects, alizapride is of value in premedication for endoscopy.
authors.forename: A
authors.initials: A
authors.lastname: Bongiorno
authors.forename: M G
authors.initials: MG
authors.lastname: Cataldo
authors.forename: A
authors.initials: A
authors.lastname: Salvia
authors.forename: A
authors.initials: A
authors.lastname: D'Aiuto
authors.forename: C
authors.initials: C
authors.lastname: Ciranni
mesh_terms: D000293:Adolescent; D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004724:Endoscopy; D006801:Humans; D008787:Metoclopramide / Q000627:therapeutic use*; D008875:Middle Aged; D010919:Placebos; D011292:Premedication; D011759:Pyrrolidines / Q000627:therapeutic use*
chemical_list: D000932:Antiemetics; D010919:Placebos; D011759:Pyrrolidines; D008787:Metoclopramide; C033968:alizapride
vernacular_title: L'alizapride in endoscopia digestiva superiore. Studio in doppio cieco contro metoclopramide e contro placebo.