Prothymosin alpha is not a nuclear polypeptide.
Using a radioimmunoassay for the NH2-terminus of prothymosin alpha, the crossreactive material was measured in subcellular fractions of calf thymus and liver. No significant amount of crossreactive material was found in the nucleus. This provides experimental evidence against a recent hypothesis, based on structural evidence, that prothymosin alpha is a nuclear polypeptide.
Tsitsiloni
O E
OE
Zoological Laboratory, Faculty of Sciences, University of Athens, Greece.
Yialouris
P P
PP
Sekeri-Pataryas
K
K
Haritos
A A
AA
D000818:Animals; D002417:Cattle; D002467:Cell Nucleus / Q000032:analysis*; D003593:Cytoplasm / Q000032:analysis; D008099:Liver / Q000648:ultrastructure; D011498:Protein Precursors / Q000032:analysis*; D011863:Radioimmunoassay; D013947:Thymosin / Q000031:analogs & derivatives* / Q000032:analysis; D013950:Thymus Gland / Q000648:ultrastructure
D011498:Protein Precursors; C040782:prothymosin alpha; D013947:Thymosin