title: Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs.
abstract: Rat pups were treated with monoamine uptake inhibiting antidepressant drugs, desipramine, imipramine or nomifensine (5 mg/kg) during the second and third postnatal weeks, and their later behavioral "despair," measured by Porsolt's swim test, was examined. At the age of two months, the desipramine-treated rats showed lengthened immobility in the swim test, and thus probably increased behavioral "despair." They also responded to 1 g/kg alcohol by shortening the immobility to the level of control rats. Neonatal treatment with either imipramine or nomifensine did not affect the swim test behavior. The results suggest that a low, stimulatory dose of alcohol was able to reverse the lengthened immobility in the swim test of rats treated with desipramine during the early postnatal period.
authors.affiliation: Centro de Estudios Farmacologicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Buenos Aires, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Fernandez-Pardal
authors.forename: L A
authors.initials: LA
authors.lastname: Hilakivi
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000928:Antidepressive Agents / Q000494:pharmacology*; D003863:Depression / Q000523:psychology*; D003891:Desipramine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009627:Nomifensine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000928:Antidepressive Agents; D009627:Nomifensine; D000431:Ethanol; D007099:Imipramine; D003891:Desipramine