Metabolism of androstenedione by placental microsomes in pregnancy hypertension.
The metabolism of [19-3H3]androstenedione by human placental microsomes was studied in vitro by radiometric analysis which distinguishes between 19-hydroxylation and elimination of the C-19 carbon. The ratio of the metabolic products tritiated water/tritiated formic acid is significantly greater for microsomes from patients with pregnancy hypertension when compared with normotensive pregnant women. This indicates that aromatization (2-hydroxylation) is deficient in pregnancy hypertension.
Hähnel
M E
ME
Department of Obstetrics and Gynaecology, University of Western Australia.
Martin
J D
JD
Michael
C A
CA
Hähnel
R
R
D000735:Androstenedione / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism*; D010084:Oxidation-Reduction; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000378:metabolism*
D000735:Androstenedione