Effect of systemic and orally administered iota-carrageenan on ovalbumin-specific antibody response in the rat.
Iota-carrageenans are high molecular weight polygalactans commonly used in the food industry. Their immunomodulating effects were examined on the reaginic and IgG ovalbumin-specific responses after systemic or oral administration to Brown Norway rats. Intraperitoneal injection of ovalbumin with either iota-carrageenan or alum induced both a reaginic and IgG response. Reaginic antibodies were detected in the primary response with alum, but only in the secondary response with iota-carrageenan. Oral tolerance to ovalbumin was similarly induced whether the protein was given alone or admixed in solution with iota-carrageenan. These results confirmed the systemic adjuvant action of iota-carrageenan described earlier, and showed that this effect did not take place when orally administered.
Coste
M
M
Institut National de la Recherche agronomique, Laboratoire des Sciences de la Consommation, Jouy-en-Josas, France.
Dubuquoy
C
C
Tomé
D
D
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002351:Carrageenan / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D010047:Ovalbumin / Q000276:immunology*; D051381:Rats; D011914:Rats, Inbred BN
D000276:Adjuvants, Immunologic; D002351:Carrageenan; D010047:Ovalbumin