title: [The trial use of alpha-IFN in treating a case of chronic myelomonocytic leukemia with splenic infarction].
abstract: A 75-year-old man, previously diagnosed as having chronic myelomonocytic leukemia, suffered an attack of severe left hypochondralgia in July 1986. A splenic infarction was diagnosed by both ultrasound tomography and computerized tomography. The patient was treated with alpha-Interferon (600 M.U./day i.m.) for cytoreduction in order to prevent a recurrence of the splenic infarction. Twenty-one days later, the peripheral white blood cell count decreased from 44,110 microliters to 9800/microliters and the monocytoid immature cells disappeared. However, severe dementia appeared and so alpha-Interferon therapy was abandoned. In this report the beneficial effects and side effects of alpha-interferon in the treatment of chronic myelomonocytic leukemia are discussed.
authors.affiliation: 1st Dept. of Int. Med., Kyoto Prefectural Univ. of Med.
authors.forename: S
authors.initials: S
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Yokoo
authors.forename: M
authors.initials: M
authors.lastname: Ozawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Horiuchi
authors.forename: M
authors.initials: M
authors.lastname: Kondo
mesh_terms: D000368:Aged; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D015477:Leukemia, Myelomonocytic, Chronic / Q000097:blood / Q000150:complications / Q000628:therapy*; D007958:Leukocyte Count; D007964:Leukocytosis / Q000097:blood / Q000150:complications / Q000628:therapy; D008297:Male; D012008:Recurrence; D013159:Splenic Infarction / Q000097:blood / Q000209:etiology* / Q000517:prevention & control
chemical_list: D007370:Interferon Type I