Growth stimulation of T47D human breast cancer cells by the anti-progestin RU486.
Our laboratory has previously reported that physiological levels of progestins stimulate growth of the human breast cancer cell line T47D. We have also determined that the antiprogestin RU486 inhibits this stimulation. Here we present the unexpected finding that RU486 alone also stimulates growth of these breast cancer cells. Thus, RU486 exhibits both antagonist and agonist-like activity, in a manner somewhat reminiscent of the antiestrogen tamoxifen. To our knowledge, this is the first report of stimulation of breast cancer growth by RU486.
Bowden
R T
RT
Department of Biochemistry, Marshall University School of Medicine, Huntington, West Virginia 25704.
Hissom
J R
JR
Moore
M R
MR
D001943:Breast Neoplasms / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004963:Estrenes / Q000494:pharmacology*; D006801:Humans; D015735:Mifepristone; D011372:Progestins / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured
D004963:Estrenes; D011372:Progestins; D015735:Mifepristone