[The effect of dalargin on systemic hemodynamics and microcirculation in experimental traumatic shock].
Experiments were conducted on rats and hamsters to study the effect of the synthetic analogue of leu-enkephalin dalargin injected in the early phase of traumatic shock. In experiments on hamsters, short-term increase in arterial pressure (AP) and improvement of microcirculation occurred in the first minutes after the injection. The AP did not increase in rats. This was followed by reduction of AP, deceleration of the blood flow in the microvessels, and increase in the diameter of arterial vessels. These processes developed more rapidly than in the controls. Survival decreased significantly among rats and had a tendency to reduce among hamsters. It is assumed that the inhibiting effect of dalargin on the higher regulating centres of vegetative functions, which is characteristic of opioid peptides, contributed to aggravation of the pathological processes developing in shock and leading to the death of the animals.
Donskikh
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EA
Kozhevnikova
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IM
D000818:Animals; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D051381:Rats; D012774:Shock, Traumatic / Q000188:drug therapy / Q000503:physiopathology*
D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Deĭstvie dalargina na sistemnuiu gemodinamiku i mikrotsirkuliutsiiu pri éksperimental'nom travmaticheskom shoke.