title: The slow inward calcium current is responsible for a part of the contraction of patch-clamped rat myoballs.
abstract: The slow inward calcium current and the contractile response were simultaneously recorded in voltage clamped (whole cell patch clamp recording) rat myoballs in primary culture. The shape of the contraction(T)/potential(V) relationship and the application of the inorganic calcium channel blocker cadmium (1.5 mM), which suppresses a part of the contractile activity, demonstrate the existence of two components of contraction. One of them is related to the slow calcium current.
authors.affiliation: Laboratory of General Physiology, CNRS U.A. 290, University of Poitiers, France.
authors.forename: M
authors.initials: M
authors.lastname: Rivet
authors.forename: C
authors.initials: C
authors.lastname: Cognard
authors.forename: G
authors.initials: G
authors.lastname: Raymond
mesh_terms: D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D019256:Cadmium Chloride; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D004553:Electric Conductivity; D008564:Membrane Potentials / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000166:cytology; D051381:Rats
chemical_list: D002104:Cadmium; D019256:Cadmium Chloride; D002118:Calcium