[Effective revaccination against tetanus in adults].
Immunologic response in persons revaccinated against tetanus was dealt with in this paper. Out of 35 examined patients with the mean age of 47.4 years on the day of revaccination 20% of them had titres of antitetanus antibodies on the lower limit which guaranteed antitetanus protection (0.01-0.02 i.j./m.). Values of titre were below 1.00 i.j./m. in one third of patients. A high degree of negative correlation was statistically established between the age of patients and the height of titre (p less than 0.001). Mean geometric titre (GMT) of the patients amounted to 1.32 i.j./ml on the day of revaccination. Seven days following revaccination GMT was 10.41 i.j./ml and it was the best illustration of immunity "eruption" induced by one dose of Te Al vaccine a 0.5 ml. Optimal values of the titre (over 1.00 i.j./ml) occurred in all examined patients. Dependence of revaccinated titre upon age was of less significance (P = 0.01). A high degree of dependence of revaccinated titre upon the values on the day of revaccination was statistically established (p less than 0.001). It was concluded that by revaccination of persons with the lowest protective titre as well a safe antitetanus protection was provided in a 7-day period. This conclusion also necessitated obligatory immunization against tetanus at an older age too whereby a more expensive active-passive treatment of injured persons would de avoided.
Bozović
M
M
Pavlović
V
V
Krese
M
M
Gajić
M
M
Dotlić
R
R
D000907:Antibodies, Bacterial / Q000032:analysis*; D003017:Clostridium tetani / Q000276:immunology; D006801:Humans; D007117:Immunization, Secondary; D008875:Middle Aged; D013745:Tetanus Toxoid / Q000276:immunology*
D000907:Antibodies, Bacterial; D013745:Tetanus Toxoid
Efekti revakcinacije protiv tetanusa kod odraslih.