Intraperitoneal P-32 after negative second-look laparotomy in ovarian carcinoma.
Thirty-one patients underwent a negative second-look laparotomy between 1976 and 1986. Fourteen patients received intraperitoneal chromic phosphate (P-32) after a negative second-look laparotomy. There has been no local recurrence (zero of 14) and no deaths attributable to recurrent disease. Local control and disease-free survival are 100%, with a minimum follow-up of 2 years and a mean follow-up of 4 years. Seventeen patients received no further therapy because of patient refusal, poor diffusion, or other contraindications to P-32 installation. Four of 17 patients undergoing negative second-look procedures without the addition of P-32 have subsequently recurred. This difference is highly suggestive (P = .076). There have been no major complications with the addition of P-32. The use of intraperitoneal P-32 after negative second-look laparotomies on ovarian carcinoma is well tolerated and effective in preventing recurrence.
Spencer
T R
TR
Medical University of South Carolina, Department of Radiation Oncology, Charleston 29425.
Marks
R D
RD
Fenn
J O
JO
Jenrette
J M
JM
Lutz
M H
MH
D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007263:Infusions, Parenteral; D007813:Laparotomy; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D010051:Ovarian Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D010761:Phosphorus Radioisotopes / Q000008:administration & dosage*; D012086:Reoperation
D010761:Phosphorus Radioisotopes