Diminished hypotensive response to isoproterenol in streptozotocin-diabetic rats.
1. The cardiovascular reactivity of streptozotocin-diabetic rats has been evaluated with isoproterenol (ISO), a strong beta-adrenergic agonist able to produce, at large dose, myocardial infarction. 2. In the basal state, diabetic rats presented significantly lower heart rate (P less than 0.001), a decreased systolic (P less than 0.05) and an unaltered diastolic blood pressure compared to non-diabetics. 3. Following ISO stimulation, the chronotropic response was similar in both groups of rats, while the fall in systolic and diastolic pressure was markedly reduced compared to those of non-diabetic rats (P less than 0.001). 4. These results suggest that the vasodilation capacity of diabetic rats is diminished.
Jobidon
C
C
Unité de Recherche sur le Diabète, Le Centre Hospitalier de l'Université Laval, Sainte-Foy, Québec, Canada.
Nadeau
A
A
Tancrède
G
G
Rousseau-Migneron
S
S
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003402:Creatine Kinase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D007527:Isoenzymes; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D007527:Isoenzymes; D003402:Creatine Kinase; D007545:Isoproterenol