title: Photosensitization with derivatives of chlorophyll.
abstract: The properties of several chlorophyll derivatives were examined: the methyl esters of pheophorbide A, pheophorbide B and pheophytin. In spite of structural differences, all products were equally effective sensitizers in vitro and were localized equally well by murine tumors in vivo after 1 h. But only the pheophytins persisted at neoplastic loci for 24 h. There was no evidence of hydrolysis of the methyl esters, but the phytyl ester linkage was labile in vivo.
authors.forename: D
authors.initials: D
authors.lastname: Kessel
authors.forename: K
authors.initials: K
authors.lastname: Smith
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects* / Q000528:radiation effects; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000473:pathology; D008027:Light; D051379:Mice; D011838:Radiation-Sensitizing Agents; D013050:Spectrometry, Fluorescence; D014407:Tumor Cells, Cultured / Q000166:cytology* / Q000187:drug effects / Q000528:radiation effects
chemical_list: D011838:Radiation-Sensitizing Agents; D002734:Chlorophyll