[Treatment of patients with acute nonlymphoblastic leukemia with low doses of cytarabine].
The analysis has been presented of the treatment of 35 patients (mainly middle-aged) with acute non-lymphoblastic leukemia, 27 of them untreated. Repeated 2-3-week courses of subcutaneous injections of cytarabine were used (10 mg/m2, twice a day). A total of 5 complete and 4 partial remissions were recorded. The frequency of complete remissions among the patients who received 2 and more courses of the drug therapy comprised 38.8%. Complete remissions were observed in primary patients with initially lowered or normal leucocyte count in the blood, with partially retained granulocytopoiesis, and a relatively slow progressing of the disease. The mechanisms of action of low doses of cytarabine has been considered.
Shvidel'
L M
LM
Iavorkovskiĭ
L I
LI
Zile
M A
MA
Klutse
G K
GK
D000368:Aged; D003561:Cytarabine / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction
D003561:Cytarabine
Lechenie bol'nykh ostrymi nelimfoblastnymi leĭkozami malymi dozami tsitozara.