Thrombocytosis associated with a myeloproliferative disorder in a dog.
A dog with a myeloproliferative disorder and thrombocytosis had clinical signs that were consistent with a diagnosis of essential thrombocythemia. The dog was treated with aspirin, radioactive phosphorus, and melphalan. Eighteen months after referral, the disorder progressed to chronic granulocytic leukemia, and treatment was switched to hydroxyurea. Fourteen months later, the dog was euthanatized because of uncontrollable atrial fibrillation.
Degen
M A
MA
Small Animal Internal Medicine Service, Veterinary Medical Teaching Hospital, University of California, Davis 95616.
Feldman
B F
BF
Turrel
J M
JM
Goding
B
B
Kitchell
B
B
Mandell
C P
CP
D000818:Animals; D001792:Blood Platelets / Q000648:ultrastructure; D003131:Combined Modality Therapy; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D006918:Hydroxyurea / Q000627:therapeutic use; D008297:Male; D008854:Microscopy, Electron; D009196:Myeloproliferative Disorders / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D010761:Phosphorus Radioisotopes / Q000627:therapeutic use; D011859:Radiography; D013163:Splenomegaly / Q000000981:diagnostic imaging / Q000662:veterinary; D013922:Thrombocytosis / Q000150:complications / Q000662:veterinary*
D010761:Phosphorus Radioisotopes; D006918:Hydroxyurea