title: Monoclonal immunoglobulin gene rearrangement in peripheral lymphocytes of a patient with multiple myeloma.
abstract: We analyzed the immunoglobulin (Ig) heavy chain gene rearrangement in the peripheral blood lymphocytes of a patient with multiple myeloma (MM). Although the morphological and immunological examination did not reveal the presence of circulating plasma cells, a monoclonal Ig gene rearrangement was detected. This observation indicates that a monoclonal expansion of circulating B cells was present in the peripheral lymphocytes of this patient.
authors.affiliation: Department of Medicine and Experimental Oncology, University of Torino, Italy.
authors.forename: A P
authors.initials: AP
authors.lastname: Palumbo
authors.forename: A
authors.initials: A
authors.lastname: Pileri
authors.forename: S
authors.initials: S
authors.lastname: Battaglio
authors.forename: P
authors.initials: P
authors.lastname: Omedè
authors.forename: V
authors.initials: V
authors.lastname: Redoglia
authors.forename: M
authors.initials: M
authors.lastname: Massaia
authors.forename: U
authors.initials: U
authors.lastname: Dianzani
authors.forename: M
authors.initials: M
authors.lastname: Boccadoro
mesh_terms: D004247:DNA / Q000032:analysis; D005260:Female; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics / Q000276:immunology*
chemical_list: D004247:DNA