title: Penetration of the fragrance compounds, cinnamaldehyde and cinnamyl alcohol, through human skin in vitro.
abstract: The delivery of cinnamaldehyde and cinnamyl alcohol in fragrance through human skin has been investigated by in vitro penetration studies using full thickness human skin. Cinnamaldehyde was transformed to cinnamyl alcohol and cinnamic acid in the skin. The transformation took place in model protein solution, bovine serum albumin, as well as in skin homogenates. After conjugation of cinnamaldehyde with the protein, a lag time was observed after which cinnamyl alcohol and cinnamic acid were released. On the other hand, cinnamyl alcohol was not transformed in detectable amounts to either cinnamaldehyde or cinnamic acid during penetration of the skin.
authors.affiliation: Pharmaceutical Research and Development Department, Pharmacia AS, Hillerød, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Weibel
authors.forename: J
authors.initials: J
authors.lastname: Hansen
mesh_terms: D000433:1-Propanol / Q000493:pharmacokinetics; D000171:Acrolein / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D000447:Aldehydes / Q000493:pharmacokinetics*; D001711:Biotransformation; D066298:In Vitro Techniques; D010476:Perfume; D010539:Permeability; D020005:Propanols; D012710:Serum Albumin, Bovine / Q000378:metabolism; D012869:Skin Absorption; D013997:Time Factors
chemical_list: D000447:Aldehydes; D010476:Perfume; D020005:Propanols; D012710:Serum Albumin, Bovine; D000171:Acrolein; D000433:1-Propanol; C012843:cinnamaldehyde; C020722:cinnamyl alcohol