Anti-thyroid peroxidase antibody activity in sera of patients with systemic lupus erythematosus.
Although patients with SLE have autoantibodies to thyroid peroxidase (TPO), IgG from sera of SLE patients does not inhibit TPO activities, in contrast with IgG from sera of patients with thyroid disorders. This finding suggests that the specificities of anti-TPO autoantibodies in SLE are different from those in cases of thyroid disorders. These autoantibodies to TPO should be considered when searching for associations between SLE and autoimmune thyroid disorders.
Kohno
Y
Y
Department of Pediatrics, School of Medicine, Chiba University, Japan.
Naito
N
N
Saito
K
K
Hoshioka
A
A
Niimi
H
H
Nakajima
H
H
Hosoya
T
T
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology*; D005260:Female; D006111:Graves Disease / Q000276:immunology; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D013961:Thyroid Gland / Q000503:physiopathology; D013967:Thyroiditis, Autoimmune / Q000276:immunology
D001323:Autoantibodies; D007453:Iodide Peroxidase