Structure elucidation of ficellomycin.
The structure of ficellomycin, an antibiotic previously discovered by Argoudelis et al., is elucidated as valyl-2-[4-guanidyl-1-azabicyclo[3.1.0]hexan-2-yl]glycine (1) by NMR, MS, and derivatization studies. The 1-azabicyclo[3.1.0]hexane moiety in 1 represents an unusual ring system making ficellomycin a unique natural product compound.
Kuo
M S
MS
Research Laboratories, Upjohn Company, Kalamazoo, Michigan 49001.
Yurek
D A
DA
Mizsak
S A
SA
D000900:Anti-Bacterial Agents; D055598:Chemical Phenomena; D002621:Chemistry; D036341:Intercellular Signaling Peptides and Proteins; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010455:Peptides
D000900:Anti-Bacterial Agents; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C013532:ficellomycin