title: Prediction of protein secondary structure based on physical theory. Histones.
abstract: Secondary structures of histones H1, H2A, H2B, H3, H4 and H5 have been calculated by the computer program ALB based on a molecular theory of protein secondary structure. The predicted secondary structures of all histones are predominantly alpha-helical. The calculated secondary structure of linker histones H1 and H5 is close to that previously obtained from two-dimensional NMR data. For each of the core histones (H2A, H2B, H3, H4) one long alpha-helix and several short ones have been predicted. These long helices can be identified with rods in the low-resolution electron density map.
authors.affiliation: Institute of Protein Research, Academy of Sciences of the USSR, Moscow.
authors.forename: O B
authors.initials: OB
authors.lastname: Ptitsyn
authors.forename: A V
authors.initials: AV
authors.lastname: Finkelstein
mesh_terms: D003198:Computer Simulation; D006657:Histones; D011237:Predictive Value of Tests; D011487:Protein Conformation
chemical_list: D006657:Histones