Eye movements induced by microinjection of GABA agonist in the rat substantia nigra pars reticulata.
Injection of muscimol (GABA agonist) in the substantia nigra pars reticulata (SNr) of the alert rat induced a continual repetition of fast eye movements to the contralateral side, each of which was followed by a slow returning movement. The fast eye movements were similar to spontaneous saccades. Larger saccades were accompanied by contralateral neck muscle activity. We suggest that the SNr plays an important role in control of eye movements in the rat.
Sakamoto
M
M
Department of Physiology, Toho University School of Medicine, Tokyo, Japan.
Hikosaka
O
O
D000818:Animals; D004576:Electromyography; D005133:Eye Movements / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D009068:Movement / Q000187:drug effects; D009118:Muscimol / Q000494:pharmacology*; D009334:Neck Muscles / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012438:Saccades / Q000187:drug effects*; D013378:Substantia Nigra / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D009118:Muscimol; D005680:gamma-Aminobutyric Acid