The mammalian cdc2 protein kinase: mechanisms of regulation during the cell cycle.
Recent experimental evidence has demonstrated the central role of the cdc2 protein kinase in the transition from G2 to M phase in eukaryotic cells. We shall review our knowledge of the mechanisms which coordinate activation of the kinase with cell cycle-specific events in mammalian cells.
Draetta
G
G
Cold Spring Harbor Laboratory, New York 11724.
Beach
D
D
D000818:Animals; D016203:CDC2 Protein Kinase; D002453:Cell Cycle; D004789:Enzyme Activation; D005656:Fungal Proteins / Q000378:metabolism; D005809:Genes, Regulator; D006801:Humans; D008938:Mitosis; D009687:Nuclear Proteins / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*
D005656:Fungal Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; D011494:Protein Kinases; D016203:CDC2 Protein Kinase