Studies on the monoamine oxidase (MAO) inhibitory potency of TL-1, isolated from a fungus, Talaromyces luteus.
The compound tentatively named TL-1 was isolated from Talaromyces luteus as a metabolite having monoamine oxidase (MAO) inhibitory potency. TL-1 showed mixed-type inhibition of MAO in mouse liver when kynuramine was used as a substrate, and the IC50 was 6.6 microM. The inhibition constants (Ki) for MAO-A and -B in mouse liver were 39.9 and 7.85 microM, respectively. On the other hand, the Ki values for MAO-A and -B in mouse brain were 74.0 and 0.71 microM, respectively. Despite the marked structural resemblance between TL-1 and 7-episclerotiorin, the latter compound had little inhibitory effect on MAO.
Satoh
Y
Y
Yamazaki
M
M
D000818:Animals; D001203:Ascomycota / Q000378:metabolism*; D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*
D001578:Benzopyrans; D008996:Monoamine Oxidase Inhibitors; C059894:TL 1