title: Induction of gastric cancer in monkeys by N-methyl-N-nitro-N-nitrosoguanidine (MNNG).
abstract: N-methyl-N-nitro-N-nitrosoguanidine (MNNG) was administered to 9 Macaca fascicularis monkeys (7 males and 2 females) through a tube at a dose of 40 mg/kg body weight 3 times a month. Tumors of the pyloric part of the stomach were observed in 2 male monkeys after MNNG doses of 800 and 848 mg/kg body weight, with a latent period of tumor development of 49 and 50 weeks, respectively. Histologically, in one case the tumor was a solid carcinoma, and in the other it had a mixed structure showing alternating solid and signet ring cell carcinoma areas.
authors.affiliation: Oncological Research Center, Ministry of Health of the Georgian SSR, Tbilisi.
authors.forename: L K
authors.initials: LK
authors.lastname: Sharashidze
authors.forename: D Sh
authors.initials: DSh
authors.lastname: Beniashvili
authors.forename: N I
authors.initials: NI
authors.lastname: Sherenesheva
authors.forename: N G
authors.initials: NG
authors.lastname: Turkia
mesh_terms: D000818:Animals; D005260:Female; D008252:Macaca fascicularis; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology
chemical_list: D008769:Methylnitronitrosoguanidine