title: Intestinal lymphangiectasia markedly improved with antiplasmin therapy.
abstract: A 35-yr-old woman with intestinal lymphangiectasia was treated with trans-4-aminomethyl cyclohexane carboxylic acid. After 6 wk of antiplasmin therapy, her serum total protein increased to normal levels and 131I-polyvinyl pyrrolidone excretion was also normalized. With a daily administration of trans-4-aminomethyl cyclohexane carboxylic acid, the patient has manifested no symptoms for 8 yr up to the present. Throughout the clinical course, the values for euglobulin lysis time showed a close relationship to changes in serum total protein. It was then suggested that increased plasma fibrinolysis may enhance lymphatic permeability to plasma proteins. During this treatment, a decreased percentage of T lymphocytes became normalized together with serum immunoglobulin values. In addition, the therapy has resulted in the disappearance of duodenal lesions observed endoscopically.
authors.affiliation: Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mine
authors.forename: S
authors.initials: S
authors.lastname: Matsubayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Nakai
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
mesh_terms: D000328:Adult; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008201:Lymphangiectasis, Intestinal / Q000175:diagnosis / Q000188:drug therapy*; D011504:Protein-Losing Enteropathies / Q000188:drug therapy*; D014148:Tranexamic Acid / Q000627:therapeutic use*
chemical_list: D003509:Cyclohexanecarboxylic Acids; D014148:Tranexamic Acid