title: [Acceleration of orthodontically induced tooth movement through the local application of prostaglandin (PGE1)].
abstract: A preliminary study was designed to assess the effect of prostaglandin E1 on tooth movement. In 5 patients palatal attachments were bonded on corresponding upper left and right premolars which were to be extracted later in the course of routine orthodontic treatment. A transpalatal elastic exerted reciprocal force on the teeth. Following local anaesthesia, 0.1 ml of a 0.01% (w/v) PGE1 solution in saline was injected under the mucoperiosteum palatal to the test tooth and 0.1 ml saline palatal to the contralateral control tooth. Injections were repeated at weekly intervals. On average, the PGE1-treated teeth moved 3 times faster than the controls but the rate of movement differed individually. Clinical and x-ray examinations of the teeth involved in the study as well as the surrounding tissues showed no evidence of pathologic changes. No negative side effects were noticed by the patients. Despite positive experiences, this treatment is not to be recommended for use in dental offices yet.
authors.forename: T
authors.initials: T
authors.lastname: Spielmann
authors.forename: L
authors.initials: L
authors.lastname: Wieslander
authors.forename: A F
authors.initials: AF
authors.lastname: Hefti
mesh_terms: D000293:Adolescent; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D009967:Orthodontic Appliances; D010513:Periodontal Ligament; D014087:Tooth Movement Techniques / Q000295:instrumentation / Q000379:methods*
chemical_list: D000527:Alprostadil
vernacular_title: Beschleunigung einer orthodontisch induzierten Zahnbewegung durch lokale Applikation von Prostaglandin (PGE1).