title: Inflammatory response in bronchoalveolar lavage fluid after inhaling histamine.
abstract: To examine the influence of the histamine chloride challenge test on the bronchoalveolar lavage cell population, lavage fluid from 15 subjects was collected 24 h after the histamine test, and was compared with the lavage fluid from a reference group of 25 subjects. Inhaled histamine is commonly used to quantitate non-specific bronchial responsiveness. Increase in airway responsiveness after exposure to ozone or allergen is associated with airway inflammation. Bronchoalveolar lavage, has therefore become a valuable tool in the study of bronchoalveolar cells and mediators in subjects with asthma and bronchial hyperresponsiveness. The total cell number and differential cell counts in bronchoalveolar lavage fluid 24 h after inhalation challenge test with histamine-chloride were studied. There was a significant increase in lymphocytes, mast cells and neutrophils after histamine test. The conclusion was that inhaled histamine-chloride can induce an inflammatory cell response in the lung. Thus the histamine-chloride test should not be performed before bronchoalveolar lavage.
authors.affiliation: Department of Pulmonary Medicine, University Hospital, Umeå, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Söderberg
authors.forename: R
authors.initials: R
authors.lastname: Lundgren
authors.forename: L
authors.initials: L
authors.lastname: Bjermer
authors.forename: N
authors.initials: N
authors.lastname: Stjernberg
authors.forename: L
authors.initials: L
authors.lastname: Rosenhall
mesh_terms: D000328:Adult; D001985:Bronchial Provocation Tests / Q000009:adverse effects*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D004804:Eosinophils; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes; D008264:Macrophages; D008297:Male; D008407:Mast Cells; D008875:Middle Aged; D009000:Monocytes; D009504:Neutrophils
chemical_list: D006632:Histamine