Visual evoked potentials in dementia: a meta-analysis and empirical study of Alzheimer's disease patients.
A meta-analytic review of flash and pattern reversal visual evoked potential research indicates that elderly demented patients have longer P100 latencies than age-matched control subjects. In the present empirical research, patients with research diagnoses of probable Alzheimer's disease were compared with sex- and age-matched control subjects using P100 latencies of visual evoked potentials (VEP) elicited by flash and pattern reversal. As compared to control subjects, Alzheimer's disease patients showed significantly longer P100 latencies of the VEP elicited by pattern reversal; the flash P100 only marginally distinguished them. These findings are discussed within the context of VEP recording practices, patient selection, sex and age matching of control subjects, and the visual system.
Pollock
V E
VE
Department of Psychiatry and the Behavioral Sciences University of Southern California, School of Medicine, Los Angeles.
Schneider
L S
LS
Chui
H C
HC
Henderson
V
V
Zemansky
M
M
Sloane
R B
RB
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000503:physiopathology*; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D009410:Nerve Degeneration; D011930:Reaction Time / Q000502:physiology; D014793:Visual Cortex / Q000503:physiopathology*; D014795:Visual Pathways / Q000503:physiopathology