title: Effect of nicarbazin and narasin-nicarbazin combinations on broiler pigmentation.
abstract: An experiment was conducted with young battery-reared chickens to evaluate the effects of graded levels of nicarbazin (0, 40, 80, 120, and 160 ppm) on plasma pigmentation in the presence and absence of coccidial infection. A second experiment was also performed to determine whether nicarbazin (50 ppm) and the narasin nicarbazin combination anticoccidial (50 ppm each) affected pigmentation values in coccidia-infected and healthy chicks. Pigmentation values were expressed as micrograms beta-carotenoid equivalents per milliliter of plasma (beta-CE). Results of these studies indicated that nicarbazin improved beta-CE in both parasitized and coccidia-free chicks, but the magnitude of improvement was greater in coccidia-infected animals. Linear responses to nicarbazin additions were observed in both groups. The second experiment revealed that the effects produced in healthy chicks receiving the narasin nicarbazin combination were equivalent to those which received nicarbazin alone, indicating that the nicarbazin response in beta-CE is manifested with the combination anticoccidial as well.
authors.affiliation: Lilly Research Laboratories, Eli Lily and Company, Greenfield, Indiana 46140.
authors.forename: K W
authors.initials: KW
authors.lastname: Bafundo
mesh_terms: D000818:Animals; D002224:Carbanilides / Q000494:pharmacology*; D002338:Carotenoids / Q000097:blood; D002645:Chickens / Q000097:blood / Q000502:physiology*; D003048:Coccidiosis / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary; D003049:Coccidiostats / Q000494:pharmacology*; D004338:Drug Combinations; D008297:Male; D009528:Nicarbazin / Q000494:pharmacology*; D010858:Pigmentation / Q000187:drug effects*; D011201:Poultry Diseases / Q000188:drug therapy / Q000503:physiopathology; D011714:Pyrans / Q000494:pharmacology*
chemical_list: D002224:Carbanilides; D003049:Coccidiostats; D004338:Drug Combinations; D011714:Pyrans; D009528:Nicarbazin; D002338:Carotenoids; C013612:narasin