Non-enzymic post-translational modification of proteins in aging. A review.
Various non-enzymic post-translational changes to proteins occur in vivo and some of these progress with aging. These changes are reviewed and linked to a number of age-related diseases, and to alterations in the charge distribution on protein surfaces. Modification by cyanate and by glucose 6-phosphate causes a partial unfolding of proteins, with loss of tertiary structure but retention of secondary structure. These products are reminiscent of the intermediate state observed during folding and unfolding of some proteins.
Harding
J J
JJ
Nuffield Laboratory of Ophthalmology, University of Oxford, U.K.
Beswick
H T
HT
Ajiboye
R
R
Huby
R
R
Blakytny
R
R
Rixon
K C
KC
D000368:Aged; D000375:Aging / Q000502:physiology*; D000818:Animals; D006801:Humans; D051379:Mice; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D051381:Rats