title: Peripheral nerve injury causes transient expression of MHC class I antigens in rat motor neurons and skeletal muscles.
abstract: After a peripheral nerve lesion (rat facial and sciatic) an induction of major histocompatibility complex (MHC) antigens class I was detected immunohistochemically in skeletal muscle fibers and motor neurons. This MHC expression was transient after a nerve crush, when regeneration occurred, but persisted after a nerve cut, when regeneration was prevented. Since the time course of MHC class I expression correlates to that of regeneration a role for this cell surface molecule in regeneration may be considered.
authors.affiliation: Department of Pathology and Neurology, Karolinska Institutet, Huddinge, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Maehlen
authors.forename: I
authors.initials: I
authors.lastname: Nennesmo
authors.forename: A B
authors.initials: AB
authors.lastname: Olsson
authors.forename: T
authors.initials: T
authors.lastname: Olsson
authors.forename: H D
authors.initials: HD
authors.lastname: Schröder
authors.forename: K
authors.initials: K
authors.lastname: Kristensson
mesh_terms: D000818:Animals; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D008297:Male; D009046:Motor Neurons / Q000276:immunology* / Q000502:physiology; D009132:Muscles / Q000276:immunology* / Q000502:physiology; D009416:Nerve Regeneration; D059348:Peripheral Nerve Injuries; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D015395:Histocompatibility Antigens Class I