Effects of dietary protein and butylated hydroxytoluene on the kidneys of rats.
Semipurified diet using Na-caseinate or lactalbumin as the only protein source was given to female rats to study the influence of nephrocalcinosis on butylated hydroxytoluene (BHT) induced kidney damage. The study showed, that BHT induces nephropathy in female rats irrespective of the diet used. Pronounced nephrocalcinosis was only found in rats fed the Na-caseinate diet. Thus, this study does not indicate a connection between the development of the BHT-nephropathy and nephrocalcinosis. The results from this study once more stress the influence of the diet on reaction of the animal to experimental procedures.
Meyer
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OA
Institute of Toxicology, National Food Agency, Søborg, Denmark.
Kristiansen
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E
Würtzen
G
G
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000633:toxicity*; D002364:Caseins / Q000009:adverse effects; D004044:Dietary Proteins / Q000009:adverse effects*; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D007674:Kidney Diseases / Q000209:etiology* / Q000503:physiopathology / Q000652:urine; D007768:Lactalbumin / Q000009:adverse effects; D009397:Nephrocalcinosis / Q000150:complications / Q000503:physiopathology / Q000652:urine; D051381:Rats
D002364:Caseins; D004044:Dietary Proteins; D002084:Butylated Hydroxytoluene; D007768:Lactalbumin