[Effect of fenilin on the enzyme activity of the monooxygenase system in the rat liver during a change in the feeding].
In the August rats kept for 30 days on adequate and low protein diet there was studied the effect of a single intragastric administration of phenyline, an anticoagulant of indirect action, in a dose of 15 mg/kg on parameters of the liver monooxygenase system (N-demethylase of amidopyrine, N-hydroxylase of aniline, content of cytochromes P-450 and B5). The parameters of the rat liver monooxygenase system of the animals kept on low protein diet decreased. Under adequate diet phenyline increased the activity of N-demethylase after 12 and 24 hours. Under low protein diet the preparation normalized some parameters of the liver monooxygenase system after 12 and 24 hours and the activity of N-demethylase and N-hydroxylase after 72 hours increased significantly.
Imambaev
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D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001711:Biotransformation / Q000187:drug effects; D004044:Dietary Proteins / Q000008:administration & dosage; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000201:enzymology; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D010105:Oxygenases / Q000378:metabolism*; D010630:Phenindione / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000925:Anticoagulants; D004044:Dietary Proteins; D010630:Phenindione; D010105:Oxygenases
Vliianie fenilina na aktivnost' fermentov monooksigenaznoĭ sistemy pecheni krys pri razlichnom kharaktere pitaniia.