title: Involvement of chromosome 22 in a Merkel cell carcinoma in a patient with a previous meningioma.
abstract: The relatively simple cytogenetic findings in an aggressive metastatic Merkel cell carcinoma are reported. Deletion 2p was found in 100% of the cells. Nevertheless, this was considered a secondary (metastatic?) change because the same aberration has been found in several other kinds of malignancy. The involvement of chromosome 22 [del(22q) and -22] in 85% of the cells seemed more intriguing, considering the fact that the Merkel cell carcinoma followed a previous meningioma.
authors.affiliation: B. Gattegno Research Institute, Hasharon Hospital, Golda Medical Center, Petach Tikva, Israel.
authors.forename: F
authors.initials: F
authors.lastname: Shabtai
authors.forename: A
authors.initials: A
authors.lastname: Sternberg
authors.forename: D
authors.initials: D
authors.lastname: Klar
authors.forename: R
authors.initials: R
authors.lastname: Reiss
authors.forename: I
authors.initials: I
authors.lastname: Halbrecht
mesh_terms: D015266:Carcinoma, Merkel Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics*; D008579:Meningioma / Q000235:genetics*; D008875:Middle Aged