Animal models of renal cell carcinoma.
Animal models are extremely valuable in studying disease processes and evaluating new therapeutic modalities. RCC in men is resistant to any type of chemo- or hormonal therapeutic regimens. Developing appropriate models is therefore important to test new therapeutic modalities or to understand basic mechanisms of this malignancy. From our review renal cell tumors appear spontaneously with a certain frequency in humans, rats, mice, and hamsters, but are extremely rare in rabbits and have not been described in guinea pigs. Some tumors have been used as renal carcinoma models, such as the VX-2 in the rabbit or a mouse tumor described by Myers, which on further evaluation do not represent true RCC. The tumors described here are either chemically induced or spontaneous tumors in a variety of species and will serve investigators as a valuable resource regarding the origin and the biologic characteristics to be applied to specific experiments.
Rangel
M C
MC
Department of Urology, Cleveland Clinic Foundation, OH.
Pontes
J E
JE
D000818:Animals; D002292:Carcinoma, Renal Cell; D004195:Disease Models, Animal; D006801:Humans; D007680:Kidney Neoplasms