Hematotoxic effects in the rat of a toluene dinitro derivative after short-term exposure.
3,5-Dinitro-4-chloro-alpha,alpha,alpha-trifluorotoluene (DNCTT) is an intermediate in the synthesis of dinitroaniline herbicides and was involved in an episode of ground water pollution in 1977. The compound presents a high environmental persistence, which may have possible implications concerning public health. In one experiment male Sprague-Dawley rats were administered DNCTT for 3 days at a dose level of 150 mg/kg body wt by oral gavage. Groups of rats were sacrificed up to 10 days after the end of the administration, at 2-day intervals. Methemoglobin was increased up to Day 7; white blood cells were also increased both in peripheral blood and in bone marrow smears. Spleen relative weights were observed to increase slightly at Days 7 and 10; microscopic examination revealed marked congestion with an increased density of the spleen's white pulp. In a similar scheduled experiment, but at a dose level of 300 mg/kg body wt, the bone marrow white cell series were not affected initially, but were affected after 3 days at the end of the administration. DNCTT has a definite effect on white cells.
Guastadisegni
C
C
Laboratorio Tossicologia Comparata ed Ecotossicologia, Istituto Superiore di Sanità, Rome, Italy.
Mantovani
A
A
Ricciardi
C
C
Stazi
A V
AV
Maffi
D
D
Salvati
A M
AM
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D002263:Carboxyhemoglobin / Q000378:metabolism; D004137:Dinitrochlorobenzene / Q000031:analogs & derivatives* / Q000633:toxicity; D006402:Hematologic Diseases / Q000139:chemically induced*; D007958:Leukocyte Count; D008297:Male; D008706:Methemoglobin / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010108:Oxyhemoglobins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D004137:Dinitrochlorobenzene; D010108:Oxyhemoglobins; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; C027133:3,5-dinitro-4-chloro-alpha,alpha,alpha-trifluorotoluene; D008706:Methemoglobin; D002263:Carboxyhemoglobin