Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p.
We used molecular genetic techniques and multipoint linkage analyses to locate the gene responsible for cutaneous malignant melanoma-dysplastic nevus. We evaluated 99 relatives and 26 spouses in six families with a predisposition to melanoma. Thirty-four family members had cutaneous malignant melanoma, and 31 of these 34 also had histologically confirmed dysplastic nevi. Twenty-four family members had dysplastic nevi alone. An analysis of the cosegregation of the cutaneous malignant melanoma-dysplastic nevus trait with 26 polymorphic DNA markers on the short arm of chromosome 1 demonstrated the presence of a gene for susceptibility to melanoma. The gene was located between an anonymous DNA marker (D1S47) and the gene locus for pronatrodilatin, a commonly used reference gene (PND), in chromosome band 1p36. The odds were greater than 260,000:1 in favor of linkage at this location.
Bale
S J
SJ
Family Studies Section, National Cancer Institute, Bethesda, Md. 20892.
Dracopoli
N C
NC
Tucker
M A
MA
Clark
W H
WH
Fraser
M C
MC
Stanger
B Z
BZ
Green
P
P
Donis-Keller
H
H
Housman
D E
DE
Greene
M H
MH
D000293:Adolescent; D000328:Adult; D000368:Aged; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004416:Dysplastic Nevus Syndrome / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D008545:Melanoma / Q000235:genetics*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000235:genetics*