Ranitidine-induced chest pain.
A 45-year-old woman with no history of heart disease twice experienced chest pain after consuming a dose of ranitidine. The chest pain, which lasted about one hour, was substernal, left of midline, dull, and pounding. H2-receptors are present in cardiovascular tissues. Although several studies have not noted an effect of ranitidine on cardiac indices there have been case reports indicating a cardiac effect. There are no reports of chest pain associated with H2-blocker ingestion; however, both bradycardia and hypotension (reported effects) might cause chest pain. A discussion of the possible mechanisms is presented.
Shimp
L A
LA
College of Pharmacy, Ann Arbor, MI 48109.
Smith
M A
MA
Wahr
D W
DW
D002637:Chest Pain / Q000139:chemically induced*; D004381:Duodenal Ulcer / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D011899:Ranitidine / Q000009:adverse effects* / Q000627:therapeutic use
D011899:Ranitidine