title: An antifungal constituent from the stem bark of Butea monosperma.
abstract: The petroleum and ethyl acetate extracts of the stem bark from Butea monosperma displayed antifungal activity against Cladosporium cladosporioides. The active constituent of low polarity was isolated by bioassay-monitored chromatographic fractionation, and identified as (-)-medicarpin by comparison of physical data. The antifungal activity of (-)-medicarpin was found to be greater than that of Benlate, a standard fungicide, while (-)-medicarpin acetate also exhibited significant activity against C. cladosporiodes.
authors.affiliation: Department of Chemistry, University of Peradeniya, Sri Lanka.
authors.forename: B M
authors.initials: BM
authors.lastname: Bandara
authors.forename: N S
authors.initials: NS
authors.lastname: Kumar
authors.forename: K M
authors.initials: KM
authors.lastname: Samaranayake
mesh_terms: D000085:Acetates; D000935:Antifungal Agents / Q000302:isolation & purification*; D001578:Benzopyrans / Q000302:isolation & purification; D002963:Cladosporium / Q000187:drug effects; D010578:Petroleum; D010946:Plants, Medicinal / Q000032:analysis*; D036343:Pterocarpans; D000094162:Phytoalexins
chemical_list: D000085:Acetates; D000935:Antifungal Agents; D001578:Benzopyrans; D010578:Petroleum; D036343:Pterocarpans; C047353:medicarpin; D000094162:Phytoalexins; C007650:ethyl acetate