title: [Local anesthetics (LA). Introduction (1)].
abstract: A brief historical review of man's attempts to produce pain relief is presented, from physical measures: compression, application of cold, to anesthetic gases and up to the introduction of cocaine and its synthetic derivatives. These offer us now a wide range of drugs with characteristics and properties of local anesthetics which are more and more effective and at the same time with fewer undesirable side effects.
authors.forename: S
authors.initials: S
authors.lastname: Rubio Alonso
authors.forename: C
authors.initials: C
authors.lastname: Burgos Sanchez-Escribano
authors.forename: A J
authors.initials: AJ
authors.lastname: Chaparro Heredia
mesh_terms: D000766:Anesthesia, Dental / Q000266:history*; D000779:Anesthetics, Local / Q000266:history*; D003042:Cocaine; D049672:History, 19th Century; D049673:History, 20th Century; D008012:Lidocaine; D009609:Nitrous Oxide
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine; D003042:Cocaine; D009609:Nitrous Oxide
vernacular_title: Anestésicos locales (AL). Introducción (I).