Protection to testicular activity by a combination of 5-hydroxy L-tryptophan with a thiol compound in whole body gamma irradiated rats.
Radiation induced changes in testicular activity were studied by estimating sialic acid content in plasma and testis and 17-ketosteroids in 24 hr urine samples of male Sprague Dawley rats following 8 Gy whole body gamma ray exposure with and without pretreatment with 2-aminoethylisothiuronium bromide hydrobromide (AET) or with a combination of 5-hydroxy L-tryptophan (5-HTP) and AET. Combination of 5-HTP with AET or AET alone in optimum radioprotecting dose has significantly modified the radiation damage to the testis.
Srinivasan
M N
MN
Sarin
R C
RC
Basu
S K
SK
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013737:Testis / Q000378:metabolism* / Q000473:pathology / Q000528:radiation effects; D014916:Whole-Body Irradiation
D013438:Sulfhydryl Compounds; D006916:5-Hydroxytryptophan