title: Relationship of skin thickness to duration of diabetes, glycemic control, and diabetic complications in male IDDM patients.
abstract: Skin thickness is primarily determined by collagen content and is increased in insulin-dependent diabetes mellitus (IDDM). We measured skin thickness in 66 IDDM patients aged 24-38 yr and investigated whether it correlated with long-term glycemic control and the presence of certain diabetic complications. With univariate analysis, skin thickness was increased and significantly related to duration of diabetes (P less than .001), previous glycemic control (P less than .001), retinopathy (P less than .001), cheiroarthropathy (P less than .001), and vibration-perception threshold (P less than .05). There was a negative correlation between forced expiratory volume at 1 s (P less than .05) and vital capacity (P less than .05) with duration of diabetes. Neither skin thickness nor ankle arteriomedial wall calcification correlated with abnormal autonomic function tests. When corrected for duration of diabetes, there was a weak correlation between skin thickness and glycemic control (P less than .05) but no correlation with retinopathy, cheiroarthropathy, and vibration-perception threshold. This study confirms that there are widespread connective tissue changes in diabetes mellitus, although the biochemistry needs further elucidation.
authors.affiliation: Diabetic and Dietetic Department, University Department of Medicine, Royal Infirmary, Edinburgh, Scotland, United Kingdom.
authors.forename: A
authors.initials: A
authors.lastname: Collier
authors.forename: A W
authors.initials: AW
authors.lastname: Patrick
authors.forename: D
authors.initials: D
authors.lastname: Bell
authors.forename: D M
authors.initials: DM
authors.lastname: Matthews
authors.forename: C C
authors.initials: CC
authors.lastname: MacIntyre
authors.forename: D J
authors.initials: DJ
authors.lastname: Ewing
authors.forename: B F
authors.initials: BF
authors.lastname: Clarke
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D005541:Forced Expiratory Volume; D006339:Heart Rate; D006801:Humans; D008297:Male; D009460:Neurologic Examination; D012016:Reference Values; D012119:Respiration; D012885:Skinfold Thickness; D014797:Vital Capacity
chemical_list: D001786:Blood Glucose