The effects of lisuride, terguride and bromocriptine on intraocular pressure (IOP).
1. The effects of a single oral dose of the dopaminergic agonists lisuride (0.1 mg), terguride (0.25 mg) and bromocriptine (1.25 mg) on IOP were studied in eight normal volunteers using the non-contact tonometer. 2. Considering all post-dose measurements, compared with placebo, bromocriptine and lisuride but not terguride reduced IOP significantly in both eyes. 3. There was no significant difference between the ocular hypotensive effect of bromocriptine and lisuride. 4. Terguride reduced IOP significantly in the left eye at the 3 h time point after drug administration. 5. The result of this study confirms the reported ocular hypotensive effect of bromocriptine and showed that lisuride is as effective as bromocriptine in reducing IOP. 6. To evaluate the clinical importance of these drugs as ocular hypotensive agents other studies are needed using eye drops.
Al-Sereiti
M R
MR
Department of Clinical Pharmacology, St Bartholomew's Hospital, London.
Turner
P
P
D000328:Adult; D001971:Bromocriptine / Q000494:pharmacology*; D004311:Double-Blind Method; D004873:Ergolines / Q000494:pharmacology*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008090:Lisuride / Q000031:analogs & derivatives / Q000494:pharmacology*; D011897:Random Allocation
D004873:Ergolines; C006208:dironyl; D001971:Bromocriptine; D008090:Lisuride