[Restoration of myocardial contractile function during gradual reperfusion after total ischemia].
Isolated guinea pig hearts subjected to 25-min total normothermic ischemia and 30-min reperfusion with the initial rate exhibited a great rise in isovolumic diastolic pressure while the contractile function recovered to 34 +/- 4% of initial value. Reperfusion with gradually increased rate from 13% of initial rate to 100% resulted in better recovery of the contractile function--to 54 +/- 3% and markedly less rise in the diastolic pressure. This coincided with 28% less inosine loss. More better recovery of the myocardial contractile function (to 80 +/- 5%) was observed in experiments in which gradual reperfusion was combined with recirculation. In both gradual reperfusion series, the recovery of the heart rate and the contractile function were much delayed during first 5 min reperfusion and were associated with a rise in coronary resistance.
Shul'zhenko
V S
VS
Kuz'min
A I
AI
Kapel'ko
V I
VI
D000227:Adenine Nucleotides / Q000032:analysis; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003327:Coronary Disease / Q000503:physiopathology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction; D015425:Myocardial Reperfusion / Q000379:methods*; D013997:Time Factors
D000227:Adenine Nucleotides
Vosstanovlenie sokratitel'noĭ funktsii miokarda pri gradual'noĭ reperfuzii posle total'noĭ ishemii.