title: Attenuation of neurogenic hypertension by chronic converting enzyme inhibition.
abstract: We compared the effects produced by acute and chronic administration of captopril in sinoaortic denervated rats. In conscious undisturbed rats acute administration of captopril (10 mg/kg intravenously) produced acute transient reductions in mean arterial pressure of 16 and 26%, 6 h (mean arterial pressure 148 +/- 4 mmHg) and 24 h (133 +/- 3 mmHg) after the sinoaortic denervation, respectively. Chronic captopril treatment (30 mg/day orally) produced a permanent attenuation of the hypertension induced by sino-aortic denervation, as shown by a beat-to-beat analysis of arterial pressure for 80 min. The attenuation was 11% (131 +/- 7 versus 148 +/- 4 mmHg) and 24% (103 +/- 9 versus 133 +/- 3 mmHg) in rats studied 6 and 24 h after the sinoaortic denervation, respectively. Chronic captopril administration produced no alteration in the tachycardia, nor in the heart rate variability of the sinoaortic denervated rats; the latter was lower than that of normotensive rats. These data show that while acute administration of captopril in sinoaortic denervated rats produced a rapid hypotensive response, chronic administration produced a long-lasting attenuation of hypertension, presumably by interference with sympathetic cardiovascular control.
authors.affiliation: Heart Institute, University Hospital, Faculty of Medicine, University of São Paulo, Brazil.
authors.forename: V L
authors.initials: VL
authors.lastname: Longo
authors.forename: V M
authors.initials: VM
authors.lastname: Farah
authors.forename: M A
authors.initials: MA
authors.lastname: Gutierrez
authors.forename: E M
authors.initials: EM
authors.lastname: Krieger
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002216:Captopril / Q000627:therapeutic use*; D003714:Denervation; D004353:Drug Evaluation, Preclinical; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012850:Sinus of Valsalva / Q000294:innervation; D013997:Time Factors
chemical_list: D002216:Captopril