title: Reactive astrocytes in lesioned rat spinal cord: effect of neural transplants.
abstract: The astroglial reaction following a laceration-type surgical lesion of rat spinal cord is recognized by hypertrophy of astrocytes. This phenomenon can be readily demonstrated by enhanced immunoreactivity for glial fibrillary acidic protein (GFAP) and a recently discovered 30 kD protein (J1-31 antigen). The results reported in this article lead to the conclusion that the astroglial reaction is not influenced significantly by the transplantation of embryonic neocortical tissue to the cavity of a laceration-type lesion. These observations could be relevant to the assessment of strategies for treatment of spinal cord injury.
authors.affiliation: Department of Pathology, University of Alberta, Edmonton, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Predy
authors.forename: S K
authors.initials: SK
authors.lastname: Malhotra
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology*; D002540:Cerebral Cortex / Q000502:physiology / Q000637:transplantation*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D051381:Rats; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D005904:Glial Fibrillary Acidic Protein