Cerebral lesions in mice infected with Plasmodium berghei are the result of an immunopathological reaction.
Cerebral lesions in mice with Plasmodium berghei infections can be prevented by timely treatment with immune serum, by splenectomy, and by administration of dexamethasone. T cell deficient mice do not develop cerebral lesions. The results of these studies are compatible with the hypothesis that a pathological reaction is responsible for development of cerebral lesions in mice infected with P. berghei.
Schetters
T
T
Department of Cytology and Histology, Catholic University of Nijmegen, The Netherlands.
Curfs
J
J
van Zon
A
A
Hermsen
C
C
Eling
W
W
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D001921:Brain / Q000276:immunology / Q000473:pathology; D001927:Brain Diseases / Q000276:immunology* / Q000473:pathology; D008288:Malaria / Q000276:immunology* / Q000473:pathology; D051379:Mice; D010962:Plasmodium berghei / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D000953:Antigens, Protozoan; D014409:Tumor Necrosis Factor-alpha