Cadmium toxicity and bioantioxidants: status of vitamin E and ascorbic acid of selected organs in rat.
Effects of i.p. administered cadmium acetate (Cd, 0.4 mg/kg) was studied on the levels of vitamin E and ascorbic acid in different brain regions, liver, kidney, testis, RBC and plasma at 15, 30 and 60 days intervals in male albino rats (45 +/- 5 g). Exposure to Cd for 15 days decreased the levels of vitamin E significantly in the liver and testis only, while 30 days of treatment resulted in a significant decline in cerebellum, cerebral cortex, corpus striatum, mid-brain + hypothalamus, and plasma. Cadmium administration for 60 days caused a decrease in vitamin E in all tissues. Furthermore, a duration-dependent decrease in hepatic ascorbic acid levels was noticed. The implications of these results are discussed.
Shukla
G S
GS
Industrial Toxicology Research Centre, Lucknow, India.
Chandra
S V
SV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism*; D002104:Cadmium / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D013997:Time Factors; D014810:Vitamin E / Q000378:metabolism*
D000975:Antioxidants; D002104:Cadmium; D014810:Vitamin E; D001205:Ascorbic Acid