title: Genetic and immunopathological findings in a lymphoma family.
abstract: We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin's lymphoma, while a granddaughter had Hodgkin's disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3 level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.
authors.affiliation: Department of Preventive Medicine/Public Health, Creighton University School of Medicine, Omaha, NE 68178.
authors.forename: H T
authors.initials: HT
authors.lastname: Lynch
authors.forename: J N
authors.initials: JN
authors.lastname: Marcus
authors.forename: D D
authors.initials: DD
authors.lastname: Weisenburger
authors.forename: P
authors.initials: P
authors.lastname: Watson
authors.forename: M L
authors.initials: ML
authors.lastname: Fitzsimmons
authors.forename: H
authors.initials: H
authors.lastname: Grierson
authors.forename: D M
authors.initials: DM
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Lynch
authors.forename: D
authors.initials: D
authors.lastname: Purtilo
mesh_terms: D000328:Adult; D000368:Aged; D005190:Family; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008213:Lymphocyte Activation; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D010375:Pedigree
chemical_list: D007074:Immunoglobulin G