Examination stress, platelet peripheral benzodiazepine binding sites, and plasma hormone levels.
The maximal binding capacity (Bmax) and the equilibrium dissociation constant (KD) values for [3H]PK 11195 binding to peripheral benzodiazepine binding sites were measured in the platelets of subjects immediately after examination stress and 10 days later, as well as in unstressed controls. Increased (52%; p less than 0.05) Bmax, but unaltered KD, values were observed immediately after the stress as compared to the controls. Ten days after the stress, a slight decrease (15%) in the number of peripheral benzodiazepine binding sites was observed, but their values remained higher (29%) in comparison to unstressed controls. Levels of plasma stress hormones (cortisol, growth hormone, and prolactin) did not differ in the stressed subjects from those of the controls.
Karp
L
L
Geha Psychiatric Hospital, Beilinson Medical Center, Petah-Tiqva, Israel.
Weizman
A
A
Tyano
S
S
Gavish
M
M
D000328:Adult; D001569:Benzodiazepines / Q000378:metabolism*; D001665:Binding Sites; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism; D008297:Male; D010808:Physical Examination; D011569:Psychiatric Status Rating Scales; D012016:Reference Values; D013312:Stress, Physiological / Q000097:blood* / Q000209:etiology / Q000378:metabolism
D006728:Hormones; D007546:Isoquinolines; D001569:Benzodiazepines; C037850:PK 11195