Relation between dopaminergic control of pituitary lactotroph function and deceleration of age-related changes in serum prolactin of diet-restricted rats.
Pituitary lactotroph function has been examined in diet-restricted (6 hr/day) male and female rats and compared with that in animals fed ad lib. After 12 months the age-related increase in serum prolactin concentration was significantly attenuated in diet-restricted female rats. Similar effects were not observed in male rats. Isolated superfused anterior pituitary glands removed from rats on both feeding regimens at 12 or 18 months and challenged with dopamine in vitro (5 microM) did not show differential prolactin secretion. No significant differences were observed in serum prolactin secretion in vivo after administration of bromocriptine (3 mg/kg body weight, sc) or haloperidol (1.75 mg/kg body weight, ip). These results do not support an altered dopamine receptor function in the anterior pituitary lactotrophs. In contrast, central dopamine receptor function in rats 12 months of age was altered by dietary restriction, since the frequency of cataleptic responses to haloperidol injection (2 mg/kg body weight, ip) was significantly depressed in the test animals.
Atterwill
C K
CK
Investigative Toxicology, Smith Kline and French Research Ltd, Welwyn, Herts., England.
Brown
C G
CG
Conybeare
G
G
Holland
C W
CW
Jones
C A
CA
D000375:Aging / Q000097:blood / Q000502:physiology*; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced; D004032:Diet; D004298:Dopamine / Q000097:blood / Q000502:physiology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D010902:Pituitary Gland / Q000032:analysis / Q000166:cytology / Q000502:physiology*; D011388:Prolactin / Q000097:blood*; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*
D011954:Receptors, Dopamine; D001971:Bromocriptine; D011388:Prolactin; D006220:Haloperidol; D004298:Dopamine