title: Human leukocyte antigen (HLA) frequency among patients with nasopharyngeal carcinoma in Taiwan.
abstract: In order to assess the association between human leukocyte antigens (HLA) and nasopharyngeal carcinoma (NPC), a total of 10 familial and 10 sporadic NPC patients and 171 unrelated healthy controls were studied. HLA typing was performed using commercial trays which defined 30 specificities of HLA-A, B and C loci and 10 specificities of HLA-D locus according to the method of Tiwari and Terasaki. HLA-A2, B16 and DR1 were found to be higher among patients with NPC than unrelated healthy controls with an odds ratio (OR) and a 95% confidence interval of 5.91 (2.1-16.6), 6.00 (2.0-18.0) and 6.89 (1.3-37.5), respectively. Further analysis showed that A2(+) B16(+) haplotype was significantly associated with a much higher risk of NPC (OR = 15.5) as compared with A2(-) B16(-) haplotype. No difference in frequency distributions of HLA-A, B, C and D antigens was observed between familial and sporadic NPC patients.
authors.affiliation: Institute of Public Health, National Taiwan University College of Medicine, Taipei.
authors.forename: S B
authors.initials: SB
authors.lastname: Wu
authors.forename: S J
authors.initials: SJ
authors.lastname: Hwang
authors.forename: A S
authors.initials: AS
authors.lastname: Chang
authors.forename: T
authors.initials: T
authors.lastname: Hsieh
authors.forename: M M
authors.initials: MM
authors.lastname: Hsu
authors.forename: R P
authors.initials: RP
authors.lastname: Hsieh
authors.forename: C J
authors.initials: CJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis*; D000943:Antigens, Differentiation / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006239:Haplotypes; D006801:Humans; D016169:Lymphocyte Function-Associated Antigen-1; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D016028:Receptors, Leukocyte-Adhesion / Q000032:analysis*; D012016:Reference Values; D013624:Taiwan
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D014408:Biomarkers, Tumor; D006680:HLA Antigens; D016169:Lymphocyte Function-Associated Antigen-1; D016028:Receptors, Leukocyte-Adhesion