New derivatives of 5-nitroimidazole: synthesis and antiparasitic activity.
The synthesis and the antiparasitic evaluation of twelve new 5-nitroimidaole derivatives has been carried out. The most effective compounds were the less hydrophilic pyridinium and imidazolium salts (IV), (V) and (X), and above all the tetrahydropyridine derivatives (XII) and (XIII).
Alcalde
E
E
Lab. Quimica Organica, Facultad de Farmacia, Universidad de Barcelona, España.
Maños
L
L
Dinares
I
I
Valls
N
N
Elguero
J
J
Escario
J A
JA
Martinez
A R
AR
Igea
A
A
Osuna
A
A
Ruiz-Perez
L M
LM
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis; D000935:Antifungal Agents / Q000138:chemical synthesis; D000962:Antimalarials / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D004747:Entamoeba / Q000187:drug effects; D005872:Giardia / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014244:Trichomonas / Q000187:drug effects; D014246:Trichomonas vaginalis / Q000187:drug effects; D014344:Trypanocidal Agents / Q000138:chemical synthesis
D000871:Anthelmintics; D000935:Antifungal Agents; D000962:Antimalarials; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C052587:4-nitroimidazole