title: Electrophysiologic actions and antifibrillatory efficacy of subacute left stellectomy in a conscious, post-infarction canine model of ischemic ventricular fibrillation.
abstract: The autonomic nervous system appears to modulate ventricular arrhythmias associated with acute myocardial ischemia. This study investigated the electrophysiologic effects and antifibrillatory actions of subacute left stellectomy in a conscious, post-infarction canine model of sudden cardiac death. Twenty-two dogs with a previous anterior wall myocardial infarction and inducible ventricular arrhythmias were randomized to undergo either left stellectomy (n = 12) or remain as sham-denervated controls (n = 10). Five to 7 days post left stellectomy, there were no significant changes in heart rate, electrocardiographic intervals or ventricular refractoriness compared to sham-denervated controls. Acute posterolateral ischemia was produced in left stellectomy and sham-denervated dogs by anodal current-induced thrombosis via a previously positioned electrode in the left circumflex coronary artery. Ventricular fibrillation developed within 1 hour of the onset of ischemia (early ventricular fibrillation) in 3/12 (25%) left stellectomy dogs versus 8/10 (80%) sham-denervated controls (P less than 0.05). However, 24-hour mortality rate was 5/12 (42%) after left stellectomy versus 8/10 (80%) after sham denervation (P = 0.072). Small differences in regional myocardial norepinephrine content, which is a marker for neuronal integrity, occurred in the mid-posterolateral and mid-anteroseptal regions of the left ventricle after left stellectomy. Overall norepinephrine concentration after left stellectomy was 409.70 +/- 9.90 ng/g vs 428.07 +/- 10.84 ng/g in sham controls (P = NS). In summary, subacute left stellectomy significantly reduces the incidence of ventricular fibrillation occurring within 1 hour of the onset of acute posterolateral ischemia at a distance to a previous myocardial infarction in conscious dogs, and tends to reduce the ischemic post-infarction mortality at 24 hours after the onset of ischemia. This protective effect of left stellectomy is not due to any alteration in cardiac electrophysiologic parameters measured prior to the development of acute posterolateral ischemia, nor is it related to regional denervation as determined by myocardial tissue concentration of residual norepinephrine.
authors.affiliation: Department of Pharmacology, University of Michigan Medical School, Ann Arbor.
authors.forename: S D
authors.initials: SD
authors.lastname: Nelson
authors.forename: J J
authors.initials: JJ
authors.lastname: Lynch
authors.forename: D
authors.initials: D
authors.lastname: Sanders
authors.forename: D G
authors.initials: DG
authors.lastname: Montgomery
authors.forename: B R
authors.initials: BR
authors.lastname: Lucchesi
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004594:Electrophysiology; D006352:Heart Ventricles / Q000032:analysis / Q000294:innervation; D009203:Myocardial Infarction / Q000150:complications*; D009638:Norepinephrine / Q000032:analysis; D013233:Stellate Ganglion / Q000601:surgery*; D013564:Sympathetic Nervous System / Q000601:surgery; D014693:Ventricular Fibrillation / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*
chemical_list: D009638:Norepinephrine