Giant cell glioblastoma: a work-up of 2 cases with long survival.
Two patients, in whom visual disturbance (Case 1) and sudden hemiparalysis due to a hemorrhagic lesion (Case 2) had led to craniotomy and histological diagnosis of giant cell glioblastoma, each had an unexpectedly long survival period of 7 and 9 years, respectively. Radiologically, the tumours were well demarcated, but without any distinguishing features, by comparison with glioblastomas in general. The tumours, to a great extent, consisted of cells with large, bizarre multiple nuclei. The highly pleomorphic cells displayed strong cytoplasmic GFAP immunopositivity, which suggested an astroglial origin. Thus, these tumours were considered a variant of glioblastoma ("giant cell glioblastoma") with a more favourable prognosis than experienced by most patients with glioblastoma.
Akslen
L A
LA
Department of Pathology, Gade Institute, Bergen, Norway.
Mørk
S J
SJ
Larsen
J L
JL
Myrseth
E
E
D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000473:pathology; D005910:Glioma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000032:analysis; D010296:Parietal Lobe / Q000473:pathology; D014057:Tomography, X-Ray Computed
D009419:Nerve Tissue Proteins