Effect of a slow release transcutaneous scopolamine application on salivary flow, pH, buffering action, and salivary levels of Streptococcus mutans and lactobacilli.
A motion sickness plaster releasing a powerful antisialogogic agent, scopolamine, was tested in a double blind clinical trial for its effect on salivary parameters in 14 healthy young men. The agent caused a decline in salivary flow rates, which was most pronounced during unstimulated conditions. Salivary pH and buffer capacity were also reduced. Salivary levels of Streptococcus mutans and lactobacilli showed a tendency to increase during 2 days on the antisialogogic agent, but the effect on S. mutans levels was not statistically significant.
Arneberg
P
P
Department of Cariology, Dental Faculty, Oslo, Norway.
Storhaug
K
K
Sandvik
L
L
D000279:Administration, Cutaneous; D000328:Adult; D002021:Buffers; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D003864:Depression, Chemical; D004311:Double-Blind Method; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007778:Lactobacillus / Q000187:drug effects* / Q000302:isolation & purification; D008297:Male; D010919:Placebos; D012463:Saliva / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D012601:Scopolamine / Q000008:administration & dosage / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects; D013295:Streptococcus mutans / Q000187:drug effects* / Q000302:isolation & purification; D014987:Xerostomia / Q000139:chemically induced
D002021:Buffers; D003692:Delayed-Action Preparations; D010919:Placebos; D012601:Scopolamine