New glutarimide antibiotics, S-632-B1 and B2. II. Isolation, physico-chemical properties and chemical structure.
Antifungal antibiotics S-632-A1,A2,B1 and B2 were extracted with ethyl acetate from the filtered broth of Streptomyces hygroscopicus S-632 and isolated through a combination of conventional and reversed-phase silica gel column chromatography. On the basis of the spectral data, S-632-B1 and B2 were found to be new members of the glutarimide family of antibiotics. The chemical structures of these components were elucidated as two stereo-isomers of 3-(5,7-dimethyl-8,9-epoxy-2-hydroxy-4-oxo-6-decenyl)glutarimide.
Otani
T
T
Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan.
Minami
Y
Y
Matsumoto
H
H
Marunaka
T
T
Lou
Z X
ZX
Yu
Q W
QW
D000935:Antifungal Agents / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D015394:Molecular Structure; D010881:Piperidones / Q000302:isolation & purification; D013053:Spectrophotometry; D013237:Stereoisomerism; D013302:Streptomyces / Q000378:metabolism
D000935:Antifungal Agents; D010881:Piperidones; C059802:antibiotic S 632-B1; C007864:glutarimide