Cytogenetic effects of phenytoin and/or carbamazepine on human peripheral leukocytes.
The cytogenetic effects of phenytoin (PHT) and/or carbamazepine (CBZ) were studied to determine clastogenic potential. Comparative analysis of chromosome breakage and sister chromatid exchange (SCE) was performed between 18 patients with epilepsy receiving PHT and/or CBZ and 10 healthy nontreated controls. These studies failed to detect a significant increase in chromosome aberrations or SCEs in groups of treated individuals as compared with controls. No correlation was observed between the rate of either chromosome damage or SCEs and age, sex, drug blood level, or daily dose. The results indicate no detectable chromosome damaging effects of PHT alone, CBZ alone, or a combination of these two antiepileptic drugs (AEDs).
Flejter
W L
WL
Department of Obstetrics/Gynecology, School of Medicine, University of Maryland, Baltimore 21201.
Astemborski
J A
JA
Hassel
T M
TM
Cohen
M M
MM
D000293:Adolescent; D000328:Adult; D001773:Blood Cells / Q000187:drug effects*; D002220:Carbamazepine / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D003582:Cytogenetics; D004338:Drug Combinations; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy / Q000235:genetics; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D010672:Phenytoin / Q000627:therapeutic use*; D012016:Reference Values; D012044:Regression Analysis; D012854:Sister Chromatid Exchange / Q000187:drug effects
D004338:Drug Combinations; D002220:Carbamazepine; D010672:Phenytoin