Regulation of 5-methyltetrahydrofolate synthesis.
After an intraperitoneal injection of 100 mumol of methionine to rats, there is rapid oxidation of the methyl group of hepatic 5-methyltetrahydrofolate to formate and CO2. Recovery of the methylfolate level starts 2.5 h after the methionine injection, when the hepatic methionine level and the S-adenosylmethionine/S-adenosylhomocysteine ratio have returned to baseline values. S-Adenosylmethionine concentration is still elevated at this time.
Lumb
M
M
Haematology Section, M.R.C. Clinical Research Centre, Northwick Park Hospital, Harrow, Middx., U.K.
Bottiglieri
T
T
Deacon
R
R
Perry
J
J
Chanarin
I
I
D000818:Animals; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008715:Methionine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012435:S-Adenosylhomocysteine / Q000032:analysis; D012436:S-Adenosylmethionine / Q000032:analysis; D013763:Tetrahydrofolates / Q000096:biosynthesis*
D013763:Tetrahydrofolates; D012436:S-Adenosylmethionine; D012435:S-Adenosylhomocysteine; D008715:Methionine; C005984:5-methyltetrahydrofolate