Statistical interpretation of concentrations of magnesium, zinc, calcium, potassium, cholesterols, and creatine kinase isoenzymes in men at different stages of ischemic heart disease.
We present a statistical interpretation of plasma (Pl) and (or) erythrocyte (Erc) concentrations of magnesium, zinc, calcium, potassium, and total high-density lipoprotein (HDL) cholesterol, as well as of the activity of total creatine kinase (CK) and its CK-MB isoenzyme, in 26 men with pre-infarction syndrome (PIS) and 34 men with acute myocardial infarction (MI). Discriminant analysis allowed overall comparison of both groups and determination of the most significant variables: CK and Pl-Zn. By non-hierarchical cluster analysis we defined three homogeneous subgroups among MI men, with CK, CK-MB, and Pl-Zn differing significantly between the groups. In PIS men, Pl-Zn was correlated with Pl-Ca, whereas in MI men Pl-Zn was correlated with Pl-Mg. Stepwise regression indicated that Pl-Zn was the most significant regressor of CK in PIS men and of CK-MB in MI men. All these statistical interpretations support a special role of Pl-Zn in diagnosis and perhaps prognosis. After MI, interleukin-1 release may possibly mediate observed hypozincemia via formation of a heart Zn-metallothionein.
Speich
M
M
Laboratoire de Biochimie Pharmaceutique, Faculté de Pharmacie, Nantes, France.
Auget
J L
JL
Arnaud
P
P
D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology; D003402:Creatine Kinase / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood*; D011379:Prognosis; D013223:Statistics as Topic; D015032:Zinc / Q000097:blood*
D008076:Cholesterol, HDL; D007527:Isoenzymes; D003402:Creatine Kinase; D008274:Magnesium; D015032:Zinc; D011188:Potassium; D002118:Calcium