Effects of dilazep (Comelian) on the central purinergic system: inhibitory effects on clonidine-induced aggressive behavior.
Mice given clonidine (20-50 mg/kg i.p. and 5 micrograms i.c.v.) exhibited aggressive behavior. Dilazep as well as N6-(L-phenylisopropyl) adenosine (adenosine agonist) inhibited this behavior. Dilazep combined with N6-(L-phenylisopropyl) adenosine markedly inhibited the behavior at low doses that were without effect when given alone whereas the inhibitory effect of dilazep on the behavior was reversed by caffeine and 8-phenyltheophylline, which are adenosine antagonists. The results suggest that the inhibitory action of dilazep on clonidine-induced aggressive behavior can be substantially attributed to central purinoceptor stimulation.
Ushijima
I
I
Department of Neuropsychiatry, Yamaguchi University, School of Medicine, Ube, Japan.
Mizuki
Y
Y
Hara
T
T
Kaneyuki
H
H
Mashimoto
S
S
Kajimura
N
N
Yamada
M
M
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology*; D004109:Dilazep / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D010660:Phenylisopropyladenosine / Q000494:pharmacology; D011687:Purines / Q000502:physiology*; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology
D001381:Azepines; D011687:Purines; D010660:Phenylisopropyladenosine; D002110:Caffeine; D013806:Theophylline; C028322:8-phenyltheophylline; D004109:Dilazep; D003000:Clonidine