title: Volume related configurational changes in the aetiology of pelvi-ureteric junction obstruction.
abstract: The aetiology of pelivi-ureteric junction (PUJ) obstruction is controversial. We present four patients who had normal or equivocal intravenous pyelograms and non-obstructive Whitaker tests in whom complete pelvi-ureteric obstruction was precipitated by more rapid distension of the renal pelvis. We speculate that in vivo physiological urine flow rates and temporary kinking of PUJ produces a critical increase in pelvic volume and subsequent valvular kinking of the upper ureter, which cannot be usually achieved by maximal urine flow rates alone. Co-existence of vesico-ureteric reflux (VUR) may be a contributory factor to critical pelvic distension and tortuous PUJ. Volume related configurational changes of this type are probably a more frequent cause of PUJ obstruction than is generally recognised.
authors.forename: J
authors.initials: J
authors.lastname: De Campo
authors.forename: R
authors.initials: R
authors.lastname: Fowler
mesh_terms: D002648:Child; D002675:Child, Preschool; D004108:Dilatation, Pathologic / Q000150:complications; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007682:Kidney Pelvis; D014517:Ureteral Obstruction / Q000209:etiology*