title: Selective effector coupling of muscarinic acetylcholine receptor subtypes.
abstract: Attempts have been made by means of recombinant DNA technology to understand the molecular basis of the functional heterogeneity of the muscarinic acetylcholine receptor (mAChR). Molecularly defined mAChR subtypes have been produced from the cloned DNAs in Xenopus oocytes and NG108-15 neuroblastoma-glioma hybrid cells as transient and stable expression systems, respectively, and agonist-induced cellular responses have been examined. The results obtained provide evidence that mAChR subtypes are selectively coupled with different effector systems, albeit not exclusively.
authors.forename: K
authors.initials: K
authors.lastname: Fukuda
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: A
authors.initials: A
authors.lastname: Maeda
authors.forename: I
authors.initials: I
authors.lastname: Akiba
authors.forename: H
authors.initials: H
authors.lastname: Bujo
authors.forename: J
authors.initials: J
authors.lastname: Nakai
authors.forename: M
authors.initials: M
authors.lastname: Mishina
authors.forename: H
authors.initials: H
authors.lastname: Higashida
authors.forename: E
authors.initials: E
authors.lastname: Neher
authors.forename: A
authors.initials: A
authors.lastname: Marty
mesh_terms: D000818:Animals; D003001:Cloning, Molecular; D006801:Humans; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000235:genetics*; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000235:genetics*
chemical_list: D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic