The third histamine receptor. Highly potent and selective ligands.
The third histamine receptor was first identified on brain neurons and seems also to be present in other cells such as the lung mast cells. Hence the novel and potent H3 receptor agonist (R)-alpha-methylhistamine might find therapeutic applications in allergic diseases.
Arrang
J M
JM
Unité 109 de Neurobiologie et Pharmacologie, Centre Paul-Broca, INSERM, Paris, France.
Garbarg
M
M
Lancelot
J C
JC
Lecomte
J M
JM
Pollard
H
H
Robba
M
M
Schunack
W
W
Schwartz
J C
JC
D000818:Animals; D001921:Brain / Q000502:physiology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008024:Ligands; D008168:Lung / Q000502:physiology; D008407:Mast Cells / Q000502:physiology; D008761:Methylhistamines / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D011968:Receptors, Histamine / Q000145:classification / Q000187:drug effects / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D008024:Ligands; D008761:Methylhistamines; D010880:Piperidines; D011968:Receptors, Histamine; C052075:thioperamide