title: Dietary animal proteins and cholesterol metabolism in rats.
abstract: The effects on cholesterol metabolism in rats of diets containing various animal proteins or soy protein were studied. The animal proteins tested were casein, whey protein, fish protein, hemoglobin, plasma proteins, ovalbumin, egg-yolk protein, beef protein and chicken-meat protein. The semi-purified diets were isonitrogenous and balanced for residual fat and cholesterol in the protein preparations. The nature of the dietary protein had no effect on serum cholesterol concentration. Group mean liver cholesterol concentration was increased and fecal excretion of bile acids was decreased by all animal proteins when compared with soy protein. This study suggests that carefully balancing diets for components other than protein in the protein preparations prevents protein effects on serum cholesterol in rats but not on liver cholesterol and bile acid excretion.
authors.affiliation: Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Lapré
authors.forename: C E
authors.initials: CE
authors.lastname: West
authors.forename: M R
authors.initials: MR
authors.lastname: Lovati
authors.forename: C R
authors.initials: CR
authors.lastname: Sirtori
authors.forename: A C
authors.initials: AC
authors.lastname: Beynen
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004044:Dietary Proteins / Q000145:classification / Q000494:pharmacology*; D005243:Feces / Q000032:analysis; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats
chemical_list: D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D004044:Dietary Proteins; D002784:Cholesterol