Psychotoxic effects of ofloxacin.
Two cases of organic psychosis, induced by the new chemotherapeutic agent ofloxacin (Tarivid), are described. According to DSM-III-R and ICD 10 (draft, 1987) both cases present as different, yet well-defined diagnostic categories: the new diagnostic systems appear to be superior and markedly more differentiated than ICD-9, since they provide a more exact and comprehensive description and more specific diagnostic allocation, especially in substance-specific syndromes. The possible involvement of GABAergic and monaminergic mechanisms in this psychotic symptomatology and their relationship to hypersynchronous states are discussed in detail.
Zaudig
M
M
Max Planck Institute for Psychiatry, Munich, FRG.
von Bose
M
M
Weber
M M
MM
Bremer
D
D
Zieglgänsberger
W
W
D000328:Adult; D003866:Depressive Disorder / Q000139:chemically induced / Q000523:psychology; D005260:Female; D006801:Humans; D008875:Middle Aged; D015242:Ofloxacin / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000523:psychology*
D015242:Ofloxacin