[Effect of various forms of diet on the nitrosation of sodium metamizole (analgin tablets) under simulated conditions of the human stomach].
The influence of a simple and a more complex diet on the formation of nitrosometamizole from sodium metamizole (analgin tablets) under simulated human gastric conditions was estimated with extremely different nitrite concentrations. Only with the complex diet and only with low nitrite concentrations, the formation of nitrosometamizole was distinctly lowered. The quantitative estimation of the formed amounts was done by a colorimetric method after extraction with dichloromethane.
Ziebarth
D
D
Zentralinstitut für Krebsforschung der Akademie der Wissenschaften der DDR, Robert-Rössle-Institut, Berlin-Buch.
Kuldmäe
L A
LA
D000632:Aminopyrine / Q000031:analogs & derivatives*; D003124:Colorimetry; D004032:Diet; D004177:Dipyrone / Q000032:analysis / Q000493:pharmacokinetics*; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D009603:Nitroso Compounds / Q000032:analysis / Q000493:pharmacokinetics*; D013607:Tablets; D013997:Time Factors
D009603:Nitroso Compounds; D013607:Tablets; D000632:Aminopyrine; D004177:Dipyrone
Einfluss unterschiedlicher Diätformen auf die Nitrosierung von Metamizol-Natrium (Analgin-Tabletten) unter simulierten Bedingungen des menschlichen Magens.