title: Psychotoxic effects of ofloxacin.
abstract: Two cases of organic psychosis, induced by the new chemotherapeutic agent ofloxacin (Tarivid), are described. According to DSM-III-R and ICD 10 (draft, 1987) both cases present as different, yet well-defined diagnostic categories: the new diagnostic systems appear to be superior and markedly more differentiated than ICD-9, since they provide a more exact and comprehensive description and more specific diagnostic allocation, especially in substance-specific syndromes. The possible involvement of GABAergic and monaminergic mechanisms in this psychotic symptomatology and their relationship to hypersynchronous states are discussed in detail.
authors.affiliation: Max Planck Institute for Psychiatry, Munich, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Zaudig
authors.forename: M
authors.initials: M
authors.lastname: von Bose
authors.forename: M M
authors.initials: MM
authors.lastname: Weber
authors.forename: D
authors.initials: D
authors.lastname: Bremer
authors.forename: W
authors.initials: W
authors.lastname: Zieglgänsberger
mesh_terms: D000328:Adult; D003866:Depressive Disorder / Q000139:chemically induced / Q000523:psychology; D005260:Female; D006801:Humans; D008875:Middle Aged; D015242:Ofloxacin / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000523:psychology*
chemical_list: D015242:Ofloxacin