title: Notes on the routine intravenous use of isometamidium in the control of bovine trypanosomiasis on the Kenya coast.
abstract: Various chemotherapeutic regimes were used to control trypanosomiasis in 3,000 Boran cattle on an estate on the Kenya coast. Recently the therapeutic use of isometamidium by the intravenous route was adopted to treat individual trypanosome-infected cattle. This was in order to overcome tissue reactions encountered after intramuscular injection and also to control a "thin cow" syndrome attributed to chronic trypanosomiasis. Toxic side effects were eliminated by careful attention to the intravenous technique which was safely used in calves, pregnant cattle and bulls. Weekly blood sampling and treatments of infected individuals resulted in a reduction of cases from 2,187 to 208 out of 46,495 and 46,329 samples examined in 1985 and 1986 respectively. The standard of management was very high and although this routine successfully controlled bovine trypanosomiasis on this estate its application elsewhere is likely to be limited.
authors.affiliation: Vipingo Estate Ltd, Kenya.
authors.forename: M E
authors.initials: ME
authors.lastname: Dowler
authors.forename: D
authors.initials: D
authors.lastname: Schillinger
authors.forename: R J
authors.initials: RJ
authors.lastname: Connor
mesh_terms: D000818:Animals; D001724:Birth Weight; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D007275:Injections, Intravenous / Q000662:veterinary; D007630:Kenya; D008297:Male; D010617:Phenanthridines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011247:Pregnancy; D012307:Risk Factors; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014353:Trypanosomiasis, African / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary; D014354:Trypanosomiasis, Bovine / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D014370:Tsetse Flies
chemical_list: D010617:Phenanthridines; D014344:Trypanocidal Agents; C000702:isometamidium chloride