title: Plasma nitrendipine concentrations in elderly normotensive volunteers after single and multiple dosing.
abstract: An acute and chronic dosing pharmacokinetic study of the calcium antagonist nitrendipine was carried out in 8 normotensive volunteers (mean age 80.1 +/- 3.4 years) to investigate if drug accumulation occurred in the elderly. Subjects received 10 mg nitrendipine once daily by mouth for 8 days. Plasma nitrendipine concentrations before administration and at 0.5, 1, 2, 4, 6 and 8 hours after dosing were measured after the first and last dose. Comparison of the pharmacokinetic data from Days 1 and 8 failed to show any evidence of nitrendipine accumulation in these elderly subjects.
authors.affiliation: Orpington Hospital, Orpington, England.
authors.forename: P
authors.initials: P
authors.lastname: Crome
authors.forename: A
authors.initials: A
authors.lastname: Baksi
authors.forename: J
authors.initials: J
authors.lastname: Edwards
authors.forename: J
authors.initials: J
authors.lastname: Marley
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D009568:Nitrendipine / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D009568:Nitrendipine