Vitamin E stimulates endotoxin-inhibited monocyte migration and phagocytosis in vivo.
Intravenous administration of E. coli endotoxin (LPS, 30 micrograms/kg, iv) inhibited thioglycollate-stimulated accumulation of monocytes into the rat peritoneal cavity, measured 48 and 72 h later, by about 40%. Pretreatment of animals with vitamin E (50 mg/kg, im) restored thioglycollate-induced monocyte migration in LPS-challenged rats to control levels. Vitamin E also partially reversed LPS-induced inhibition of monocyte phagocytosis in vivo. The results suggest that vitamin E could be beneficial in restoring leukocyte function in septicemic states.
Rocha
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NP
Departamento de Farmacologia, Universidade Estadual Paulista, Botucatu, SP, Brasil.
D000818:Animals; D002464:Cell Migration Inhibition; D002465:Cell Movement / Q000187:drug effects; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D008297:Male; D009000:Monocytes / Q000502:physiology*; D010529:Peritoneal Cavity / Q000166:cytology*; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000494:pharmacology*
D004731:Endotoxins; D014810:Vitamin E