Megakaryocyte colony-stimulating factor and thrombopoiesis.
Although megakaryocyte differentiation and proliferation is understood to be regulated by "humoral" factors, the molecular identities of such factors have, until recently, been obscure. The "two factor" model of megakaryocytopoiesis/thrombopoiesis is critically reviewed. In this model, "Megakaryocyte Colony-Stimulating Factor" (Meg-CSF) determines the early differentiational events of megakaryocytopoiesis, and "Thrombopoietin" (Tpo) is held responsible for the maturation of the megakaryocyte and the biochemical/cytological events in platelet formation and release. To date, neither of these growth factors have been molecularly cloned. When this occurs, the clarification of the roles Meg-CSF, Tpo and other secondary modulators (such as IL-3 and GM-CSF) play in platelet formation in health and disease will be made manifest.
Murphy
M J
MJ
Hipple Cancer Research Center, Dayton, Ohio.
D000818:Animals; D001792:Blood Platelets; D002454:Cell Differentiation / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000502:physiology*; D058851:GPI-Linked Proteins; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007377:Interleukin-3 / Q000502:physiology; D008533:Megakaryocytes / Q000187:drug effects*; D008562:Membrane Glycoproteins; D000090204:Mesothelin; D011506:Proteins / Q000502:physiology*; D013926:Thrombopoietin / Q000502:physiology
D003115:Colony-Stimulating Factors; D058851:GPI-Linked Proteins; D007377:Interleukin-3; D008562:Membrane Glycoproteins; D011506:Proteins; D013926:Thrombopoietin; D000090204:Mesothelin