title: Translocation of zinc may contribute to seizure-induced death of neurons.
abstract: Rats were subjected to seizures induced by kainic acid, and the resulting changes in CNS zinc staining were studied with the toluene sulfonamide quinoline fluorescence method. Seizures caused a loss of zinc staining from presynaptic boutons in many limbic and cerebrocortical regions. Simultaneously, the postsynaptic neurons that were degenerating (acidophilic) in those regions as a result of the seizure developed intense fluorescence for zinc. A possible role for zinc in the death of the postsynaptic neurons is suggested.
authors.affiliation: Laboratory for Neurobiology, University of Texas at Dallas, Richardson 75080.
authors.forename: C J
authors.initials: CJ
authors.lastname: Frederickson
authors.forename: M D
authors.initials: MD
authors.lastname: Hernandez
authors.forename: J F
authors.initials: JF
authors.lastname: McGinty
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D002470:Cell Survival; D002531:Cerebellum / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D066298:In Vitro Techniques; D007608:Kainic Acid; D009410:Nerve Degeneration; D011804:Quinolines; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D013449:Sulfonamides; D014050:Toluene; D015032:Zinc / Q000378:metabolism*
chemical_list: D011804:Quinolines; D013449:Sulfonamides; D014050:Toluene; D015032:Zinc; D007608:Kainic Acid