[The effect of high glucose concentrations on the osmotic and mechanical resistance of human erythrocytes].
Incubation of citrated or heparinized blood samples with 25 or 50 mmoles/l glucose for 1 hour at 37 degrees C results in a decrease in the osmotic and mechanical resistance of red blood cells as well as in an increase in the red blood cell volume measured as increase in haematocrit. Fructose, but not sorbitol or saccharose has effects on red blood cells that are similar to those of glucose. It is discussed that an uptake of glucose into red blood cells with subsequent water influx results in swelling and decreased stability of the cells.
Lösche
W
W
Michel
E
E
Lull
K
K
Kreutzfeld
B
B
Heptinstall
S
S
Till
U
U
D004911:Erythrocyte Volume / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology*; D006400:Hematocrit; D006801:Humans; D009994:Osmolar Concentration
D005947:Glucose
Die Wirkung hoher Glucosekonzentrationen auf die osmotische und mechanische Resistenz humaner Erythrozyten.