title: High-performance liquid chromatographic evaluation of PCF 39, a new immunomodulator agent.
abstract: An high-performance liquid chromatographic analysis of PCF 39, N2-[5-(hypoxanthin-9-yl)pentyloxycarbonyl]-L-arginine, with ultraviolet detection, has been devised and validated. The main pharmacokinetic results encountered for rats treated intravenously with PCF 39 at a dose of 100 mg/kg are described.
authors.affiliation: Real srl, Como, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Marzo
authors.forename: N
authors.initials: N
authors.lastname: Monti
authors.forename: M
authors.initials: M
authors.lastname: Ripamonti
authors.forename: G
authors.initials: G
authors.lastname: Cardace
authors.forename: E
authors.initials: E
authors.lastname: Arrigoni Martelli
mesh_terms: D000276:Adjuvants, Immunologic / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D002110:Caffeine / Q000097:blood / Q000652:urine; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D007042:Hypoxanthines / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000276:Adjuvants, Immunologic; D007042:Hypoxanthines; C054420:PCF 39; D002110:Caffeine; D001120:Arginine