The effects of N-methyl-D-aspartate antagonists on the development of vestibular compensation in the guinea pig.
In order to investigate the possible role of the N-methyl-D-aspartate (NMDA) receptor in the development of the behavioural recovery which occurs following unilateral labyrinthectomy (vestibular compensation) in the guinea pig, we administered systemically the specific NMDA receptor/channel antagonists MK801 and CPP (3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid) during the compensation process. MK801 disrupted the development of ocular motor compensation when administered at 18-22 h post-op (1.0 mg/kg i.p.). CPP had a smaller but still significant disruptive effect when injected at this time (1.0 or 5.0 mg/kg i.p.). We conclude that NMDA receptors may contribute to the development of ocular motor compensation in the guinea pig.
Darlington
C L
CL
Department of Physiology, University of Otago, Dunedin, New Zealand.
Smith
P F
PF
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D003986:Dibenzocycloheptenes / Q000494:pharmacology; D016291:Dizocilpine Maleate; D007758:Ear, Inner / Q000502:physiology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D016202:N-Methylaspartate; D009760:Nystagmus, Physiologic / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D000927:Anticonvulsants; D003986:Dibenzocycloheptenes; D010879:Piperazines; D001224:Aspartic Acid; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid