[Effect of cortisol on estradiol secretion and its reception in the morning and evening hours in 30-day-old female rats].
Cortisol administration (250 micrograms) to 5-day-old female rats was studied for its effect on the diurnal (morning-evening) rhythm of the estradiol secretion and reception on the 30th day of life. This stimulus had no influence on the estradiol level in the morning time. In the evening the estrogen concentration in the control group decreased while in the cortisol-treated group there were no changes. Disturbance of the circadian periodicity in the serum estradiol concentration in cortisol-treated animals was not induced by changes in the secretory ability of adrenals and ovaries, which was estimated by measurement of the estradiol production by glands in vitro. This disturbance was not a result of changes in hormone reception in uterine cytosol. The increased estradiol level in cortisol-treated rats in the evening is in good agreement with effects caused by neonatal glucocorticoid treatment in the reproductive system.
Tinnikov
A A
AA
D000818:Animals; D002940:Circadian Rhythm; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D051381:Rats
D004958:Estradiol; D006854:Hydrocortisone
Vliianie kortizola na sekretsiiu éstradiola i ego retseptsiiu v utrennie i vechernie chasy u samok krys v 30-sytochnom vozraste.