Determination of selenium in drugs by oxygen flask combustion and ion chromatography.
A method is described for the determination of trace selenium (impurities in medicinal organic compounds) by ion chromatography (IC) after oxygen flask combustion. All selenium compounds formed by oxygen flask combustion are converted to selenate ion by heating with nitric acid and potassium permanganate. The selenate ion is then determined by IC, using a simple recycle system to eliminate interfering ions. The detection limit of selenium is 0.4 nmol in 50 mg of sample. The recoveries of selenium added to seven drugs are ca. 95-103% with relative standard deviations of 1-6%.
Murayama
M
M
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Suzuki
M
M
Takitani
S
S
D002845:Chromatography / Q000379:methods; D010100:Oxygen; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012643:Selenium / Q000032:analysis*
D004364:Pharmaceutical Preparations; D012643:Selenium; D010100:Oxygen