title: The influence of experimental conditions on the spectrin-hemoglobin interaction.
abstract: Human spectrin, when isolated, purified and stored in such conditions that preserve its tetrameric form, is able to associate with human hemoglobin as it is clearly shown by gel filtration. However, this hemoglobin-spectrin association does not seem to have a significant effect on hemoglobin oxygenation as indicated by equilibrium and rapid kinetics measurements.
authors.affiliation: Laboratoire de Chimie Générale I, Université libre de Bruxelles.
authors.forename: J
authors.initials: J
authors.lastname: Vincentelli
authors.forename: A
authors.initials: A
authors.lastname: Fraboni
authors.forename: C
authors.initials: C
authors.lastname: Paul
authors.forename: A G
authors.initials: AG
authors.lastname: Schnek
mesh_terms: D000268:Adhesiveness; D001667:Binding, Competitive / Q000187:drug effects; D002850:Chromatography, Gel; D006454:Hemoglobins; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009994:Osmolar Concentration; D010100:Oxygen / Q000502:physiology; D013049:Spectrin / Q000494:pharmacology
chemical_list: D006454:Hemoglobins; D013049:Spectrin; D010100:Oxygen