[Endolymphatic antibiotic therapy of allergic vasculitis].
Inadequacy of the routine methods for therapy of infectious allergic vasculitides and the necessity of sanitizing the foci of infection have prompted the application of endolymphatic administration of antibiotics. Studies of ampicillin pharmacokinetics have demonstrated that a single endolymphatic injection in a dose of 1 x 10(6) U is sufficient to maintain the therapeutic concentration of the drug in the blood serum for 24 hrs. Ampicillin has been injected into the lymph vessels of both soles in the above dose once daily for 5-7 days to 10 patients suffering from allergic vasculitis for a long time. The pathologic elements regressed by the end of the course of therapy in all the cases; only two patients have developed relapses in several months, that have been rapidly arrested.
Anton'ev
A A
AA
Batkaev
E A
EA
Rutshteĭn
L G
LG
Grigorian
A G
AG
D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001424:Bacterial Infections / Q000097:blood / Q000188:drug therapy; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007272:Injections, Intralymphatic / Q000295:instrumentation / Q000379:methods; D012008:Recurrence; D013997:Time Factors; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000097:blood / Q000188:drug therapy*
D000667:Ampicillin
Endolimfaticheskaia antibiotikoterapiia allergicheskikh vaskulitov.