title: Alterations in acid-base status and blood gas dynamics during progressive hyperkalaemia in neonatal calves.
abstract: Alterations in acid-base status and blood-gas dynamics were studied during induced progressive hyperkalaemia in neonatal calves. The hyperkalaemia was associated initially with respiratory alkalosis in arterial blood when plasma K+ was increased to 6.08 +/- 1.02 mmol litre-1. The rise of plasma K+ above 6.08 +/- 1.02 mmol litre-1 led to the development of metabolic acidosis in arterial and venous blood. There was partial respiratory compensation. Plasma K+ concentrations at or above 11.03 +/- 0.34 mmol litre-1 were associated with a decrease in arterial oxygen tension and arterial oxygen saturation. The oxygen extraction ratio was increased during hyperkalaemia.
authors.affiliation: Department of Veterinary Physiology, Punjab Agricultural University, Ludhiana, India.
authors.forename: A
authors.initials: A
authors.lastname: Singh
authors.forename: S S
authors.initials: SS
authors.lastname: Randhawa
authors.forename: M S
authors.initials: MS
authors.lastname: Setia
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000378:metabolism / Q000662:veterinary*; D000472:Alkalosis, Respiratory / Q000378:metabolism / Q000662:veterinary; D000818:Animals; D000831:Animals, Newborn; D001784:Blood Gas Analysis / Q000662:veterinary; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D006947:Hyperkalemia / Q000378:metabolism / Q000662:veterinary*