title: Pharmacokinetic properties of sustained-release theophylline (Theolair-SR) in relation to timing of doses after low-fat meals.
abstract: Pharmacodynamic and pharmacokinetic properties of sustained-release anyhdrous theophylline (Theolair-SR) were similar when doses were given either immediately after or two hours after low-fat meals in children with moderate asthma requiring daily theophylline maintenance. Asthma and pulmonary function values were maintained and approached values for healthy subjects during both treatment regimens.
authors.affiliation: Division of Allergic Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: P W
authors.initials: PW
authors.lastname: Welsh
authors.forename: E J
authors.initials: EJ
authors.lastname: O'Connell
authors.forename: M I
authors.initials: MI
authors.lastname: Sachs
authors.forename: T P
authors.initials: TP
authors.lastname: Moyer
authors.forename: K A
authors.initials: KA
authors.lastname: Wick
authors.forename: L I
authors.initials: LI
authors.lastname: Harrison
authors.forename: S E
authors.initials: SE
authors.lastname: McCarville
authors.forename: D C
authors.initials: DC
authors.lastname: Kvam
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000188:drug therapy; D002648:Child; D003692:Delayed-Action Preparations; D004041:Dietary Fats / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D005540:Forced Expiratory Flow Rates; D005541:Forced Expiratory Volume; D005652:Functional Residual Capacity; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D003692:Delayed-Action Preparations; D004041:Dietary Fats; D013806:Theophylline