title: Effects of cigarette smoke, carbon monoxide and nicotine on the uptake of fibrinogen by the canine arterial wall.
abstract: An animal model has been used to investigate the effects of cigarette smoke, carbon monoxide and nicotine on the uptake of 125I-labelled fibrinogen by the arterial wall. The uptake of fibrinogen in the smoking group (5.5 +/- 2.8 counts.cm-2 x 10(-4)) and carbon monoxide group (6.1 +/- 2.7 counts.cm-2 x 10(-4)) was greater than the uptake in the control group (4.5 +/- 1.4 counts.cm-2 x 10(-4)) but this difference was not significant. In the nicotine group, there was a highly significant increase in wall uptake of 125I-fibrinogen (9.1 +/- 2.1 counts.cm-2 x 10(-4)) (P less than or equal to 0.001). These results suggest that nicotine, a major constituent of cigarette smoke, increases the retention of 125I-fibrinogen by the arterial wall and that this might be one mechanism by which cigarette smoking exerts its atherogenic effect.
authors.affiliation: Department of Surgery, St. Thomas' Hospital, London, U.K.
authors.forename: D R
authors.initials: DR
authors.lastname: Allen
authors.forename: N L
authors.initials: NL
authors.lastname: Browse
authors.forename: D L
authors.initials: DL
authors.lastname: Rutt
mesh_terms: D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000378:metabolism*; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism; D002248:Carbon Monoxide / Q000494:pharmacology*; D002263:Carboxyhemoglobin / Q000378:metabolism; D002339:Carotid Arteries / Q000378:metabolism; D004285:Dogs; D005340:Fibrinogen / Q000378:metabolism*; D009538:Nicotine / Q000494:pharmacology*; D012907:Smoking / Q000378:metabolism*
chemical_list: D009538:Nicotine; D002248:Carbon Monoxide; D005340:Fibrinogen; D002263:Carboxyhemoglobin