A uterine leiomyoma showing both t(12;14) and del(7) abnormalities.
The involvement of chromosomes 12 and 14 in uterine leiomyomas has been well established. However, in a recent report of only a del(7)(q22.1q31.32) or (q11.2q22.3) in two cases of typical uterine leiomyoma, Boghosian et al. hypothesized that this could represent a cytogenetic subgroup of uterine leiomyomas. We report a case of uterine leiomyoma with both the t(12;14) and del(7) in all the cells examined and discuss the implications of this in terms of critical chromosomal rearrangements underlying the route to benign cellular proliferation.
Sait
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Cancer Center, Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
Dal Cin
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P
Ovanessoff
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Sandberg
A A
AA
D002872:Chromosome Deletion; D002881:Chromosomes, Human, Pair 12; D002883:Chromosomes, Human, Pair 14; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000235:genetics*; D008875:Middle Aged; D014178:Translocation, Genetic; D014594:Uterine Neoplasms / Q000235:genetics*