Technetium-99m complexes of dimethylaminomethylene diphosphonate (DMAD)--I. Anion exchange HPLC characterization of 99mTc(NaBH4)-DMAD mixtures.
Radiopharmaceutical analogs prepared by sodium borohydride reduction of 99mTcO4- in the presence of DMAD have been characterized by anion exchange HPLC (high performance liquid chromatography) separation of the resulting mixture into component 99mTc-DMAD complexes. The distribution of complexes within a radiopharmaceutical formulation can be manipulated by controlling technetium concentration, pH, presence or absence of air, and time post reaction.
Holland
M E
ME
Department of Chemistry, University of Cincinnati, OH 45221.
Heineman
W R
WR
Deutsch
E
E
D001894:Borohydrides / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D004164:Diphosphonates / Q000138:chemical synthesis*; D009942:Organometallic Compounds / Q000138:chemical synthesis*; D015609:Organotechnetium Compounds; D013667:Technetium / Q000032:analysis
D001894:Borohydrides; D004164:Diphosphonates; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; C059662:technetium Tc 99m (sodium borohydride)-dimethylaminomethylene diphosphonate; D013667:Technetium