[Lipid peroxidation and the endogenous DNA polymerase activity of fractions of isolated liver chromatin in rats].
Lipids which enter the composition of actively transcribed and repressed chromatin fractions are found to undergo a peroxidation. The peroxidation induction results in a depression of the endogenous DNA polymerase activity of these fractions. Tetrachloromethane increases the intensity of lipid peroxidation processes and induces a more marked depression of the DNA polymerase activity in all repressed chromatin fractions. It is assumed that selective action of tetrachloromethane on the studied indices of this chromatin fraction may be related to the differences of lipid composition of actively transcribed and repressed chromatin.
Gubskiĭ
Iu I
IuI
Levitskiĭ
E L
EL
Gol'dshteĭn
N B
NB
Litoshenko
A Ia
AIa
D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D002843:Chromatin / Q000187:drug effects / Q000201:enzymology*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects
D002843:Chromatin; D002251:Carbon Tetrachloride; D004259:DNA-Directed DNA Polymerase
Perekisnoe okislenie lipidov i éndogennaia DNK-polimeraznaia aktivnost' fraktsiĭ izolirovannogo khromatina pecheni krys.