title: Developmental toxicity testing with FETAX: evaluation of five compounds.
abstract: The teratogenic potential of five compounds was evaluated with FETAX (Frog Embryo Teratogenesis Assay: Xenopus). Early embryos of Xenopus laevis were exposed for 96 h to 6-aminonicotinamide (6-AN), isoniazid (INH), urethane, nitrilotriacetate (NTA) or sodium cyclamate, in two separate static-renewal tests of each compound. Based on Teratogenic Index values, growth endpoints and the types and severity of the induced malformations, 6-AN, INH and urethane scored as having strong teratogenic potential. NTA and sodium cyclamate had little or no teratogenic potential. The results support continued evaluation of FETAX as a screening assay for chemical teratogens.
authors.affiliation: Department of Zoology, Oklahoma State University, Stillwater 74078.
authors.forename: D A
authors.initials: DA
authors.lastname: Dawson
authors.forename: D J
authors.initials: DJ
authors.lastname: Fort
authors.forename: D L
authors.initials: DL
authors.lastname: Newell
authors.forename: J A
authors.initials: JA
authors.lastname: Bantle
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D007928:Lethal Dose 50; D013723:Teratogens / Q000633:toxicity*; D013997:Time Factors; D014982:Xenopus laevis
chemical_list: D013723:Teratogens