Effect of estradiol on the phosphorylation of rat liver ribosome proteins.
The effect of estradiol on phosphorylation with gamma-32P-ATP of ribosome proteins from polyribosome fraction, isolated from female rat liver is found out. Rats (180 g) used were: sham-operated, ovariectomized and treated after ovariectomy for 11 days with 20 micrograms 17 beta-estradiol-dipropionate per 100 g body weight. The estradiol deficiency after ovariectomy decreased phosphorylation, but the estrogenization of ovariectomized rats increases it twice. In vitro the hormone (1-2 mumol/l) [corrected] also stimulated ribosome protein phosphorylation. It is supposed that the hormone may take part in the regulation of protein synthesis in the translational region of the process.
Nikolov
J T
JT
Department of Human and Animal Physiology, Faculty of Biology, University of Sofia, Bulgaria.
Dimitrov
O A
OA
Kabaivanova
S D
SD
Ivanova
V L
VL
Moskova
V V
VV
D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010052:Ovariectomy; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains; D012269:Ribosomal Proteins / Q000378:metabolism*
D012269:Ribosomal Proteins; D004958:Estradiol