The entry of gossypol across the blood-testis barrier in rats.
This paper presents the experimental data about how different formulations of gossypol enter the blood-testis barrier following intravenous administration in acute experiments on rats. It was found that gossypol encapsulated by liposomes crossed the blood-testis barrier more readily than free gossypol, without affecting its pharmacokinetic pattern in the circulating blood, suggesting that liposomes may be useful as drug carriers and may facilitate the entry of encapsulated gossypol into the seminiferous tubule from the blood.
Wang
J M
JM
Department of Pharmacology, Nanjing Institute of Materia Medica, People's Republic of China.
Wen
G Y
GY
Zhang
Z R
ZR
Wu
X L
XL
Jiang
D H
DH
Tao
L
L
Cao
R Q
RQ
Zhou
Q
Q
D000818:Animals; D006072:Gossypol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007262:Infusions, Intravenous; D008081:Liposomes; D008297:Male; D051381:Rats; D013737:Testis / Q000098:blood supply / Q000378:metabolism*
D008081:Liposomes; D006072:Gossypol