Antimicrobial and immunomodulating effects of some phenolic glycosides.
Several phenolic glycosides, i.e. acteoside, desrhamnosyl acteoside, and purpureaside A, B and C, exerted weak antibacterial effects on Escherichia coli. Acteoside had antiplasmid effects, including F'lac plasmid elimination, and inhibited kanamycin resistance transfer in E. coli. Acteoside, desrhamnosyl acteoside and purpureaside A displayed antiviral effect on Aujeszky virus. All of the phenolic glycosides decreased some human leucocyte functions, including rosette formation, mitogen-induced blast transformation and phagocytic activity in vitro. The purpureaside C had significant proinflammatory action, however, other phenolic glycosides showed neither proinflammatory nor antiinflammatory effect on carrageenin-induced inflammation in vivo.
Molnár
J
J
Institute of Microbiology, University Medical School, Szeged, Hungary.
Gunics
G
G
Mucsi
I
I
Koltai
M
M
Petri
I
I
Shoyama
Y
Y
Matsumoto
M
M
Nishioka
I
I
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000920:Antibody-Dependent Cell Cytotoxicity; D000998:Antiviral Agents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006027:Glycosides / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D010587:Phagocytosis / Q000187:drug effects*; D010636:Phenols / Q000494:pharmacology*; D010957:Plasmids / Q000187:drug effects*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000998:Antiviral Agents; D006027:Glycosides; D010636:Phenols