title: A linkage group with FRA16B (the fragile site at 16q22.1).
abstract: Polymorphic DNA markers located in bands 16q13, 16q21 and 16q22 were examined for recombination with FRA16B, the fragile site at 16q22.100. A tight linkage cluster D16S10-FRA16B-D16S4-HP was established. There were no recombinants (theta = 0.0, z = 8.3) between D16S10 and D16S4, which flank FRA16B. The markers D16S10 and D16S4 are in close proximity on the genetic map and delineate a small chromosomal segment, which contains the distamycin A-inducible fragile site.
authors.affiliation: Department of Histopathology, Adelaide Children's Hospital, Australia.
authors.forename: J C
authors.initials: JC
authors.lastname: Mulley
authors.forename: V J
authors.initials: VJ
authors.lastname: Hyland
authors.forename: A
authors.initials: A
authors.lastname: Fratini
authors.forename: L J
authors.initials: LJ
authors.lastname: Bates
authors.forename: A K
authors.initials: AK
authors.lastname: Gedeon
authors.forename: G R
authors.initials: GR
authors.lastname: Sutherland
mesh_terms: D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D010375:Pedigree
chemical_list: D005819:Genetic Markers