title: [Epistaxis caused by an acquired thrombocytopathy].
abstract: Epistaxis may be the sole manifestation of a platelet aggregation dysfunction. Bleeding time according to Ivy within normal ranges does not exclude a severe disturbance of primary haemostasis. In two women (aged 53 and 76 yr, respectively) persistent epistaxis could not be stopped by local therapy. The bleeding time according to Ivy was within normal ranges in both cases. In one patient a bleeding disorder was not recognized as laboratory screening tests were normal and her situation became life-threatening. Anamnesis, clinical history and platelet aggregation tests led to the correct diagnosis; in one patient the relation with acetylsalicylic acid treatment was clear. After administration of platelet concentrate the bleeding stopped within a few hours in both cases and did not recur.
authors.forename: J A
authors.initials: JA
authors.lastname: Veldhuizen
authors.forename: J T
authors.initials: JT
authors.lastname: de Wolf
authors.forename: C T
authors.initials: CT
authors.lastname: Buiter
authors.forename: H
authors.initials: H
authors.lastname: Cats
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001241:Aspirin / Q000009:adverse effects; D001778:Blood Coagulation Disorders / Q000175:diagnosis; D001780:Blood Coagulation Tests; D001791:Blood Platelet Disorders / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D004844:Epistaxis / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin
vernacular_title: Epistaxis door verworven trombocytopathie.