Effects of pancreastatin on insulin and pancreatic polypeptide secretion in the dog.
Porcine pancreastatin (1.19 nmol) was administered into the peripheral vein (i.v.) or the third cerebral ventricle (i.t.v.) of dogs and its effect on the secretion of insulin and pancreatic polypeptide (PP) studied. Neither means of administration had any effect on basal and glucose-induced insulin or PP secretion. However, i.v. pancreastatin did inhibit the i.v. CCK-8-induced insulin but not PP release. Pancreastatin may thus play a role in the regulation of insulin secretion in the canine pancreas.
Inui
A
A
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Okita
M
M
Inoue
T
T
Sakatani
N
N
Oya
M
M
Morioka
H
H
Oimomi
M
M
Tatemoto
K
K
Baba
S
S
D000818:Animals; D053379:Chromogranin A; D004285:Dogs; D007262:Infusions, Intravenous; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D010187:Pancreatic Hormones / Q000494:pharmacology*; D010191:Pancreatic Polypeptide / Q000378:metabolism*; D010194:Pancreatin / Q000378:metabolism
D053379:Chromogranin A; D007328:Insulin; D010187:Pancreatic Hormones; C050836:pancreastatin; D010191:Pancreatic Polypeptide; D010194:Pancreatin