Chronic gamma-radiation sensitivity of skin fibroblasts from patients with non-Hodgkin's lymphoma (NHL).
Cultured skin fibroblasts from 11 patients with non-Hodgkin's lymphoma (NHL), 3 with ataxia telangiectasia (AT), 3 AT heterozygotes and 6 healthy subjects were studied for impaired colony-forming ability upon chronic exposure to gamma-radiation. A comparison of survival curves of the different cell lines revealed an AT heterozygote-like response (intermediate radiosensitivity) in 8 (73%) out of 11 NHL patients. These results suggested that the majority of the NHL patients may have an underlying abnormality of DNA repair.
Hannan
M A
MA
Department of Biological and Medical Research, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
Smith
B P
BP
Sigut
D
D
Rabe
E F
EF
Ozand
P T
PT
Ali
M A
MA
Amer
M H
MH
D000293:Adolescent; D000328:Adult; D000368:Aged; D001260:Ataxia Telangiectasia / Q000235:genetics; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D002648:Child; D002675:Child, Preschool; D004260:DNA Repair; D005260:Female; D005347:Fibroblasts / Q000528:radiation effects*; D005720:Gamma Rays; D006579:Heterozygote; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011836:Radiation Tolerance; D012867:Skin / Q000166:cytology / Q000528:radiation effects*