New glutarimide antibiotics, S-632-B1 and B2. I. Taxonomy of producing strain, fermentation and biological properties.
Strain S-632 was found to produce new glutarimide antibiotics, S-632-B1 and B2, which were isolated from the culture fluid. A taxonomic study on strain S-632 was carried out, and the taxonomic characterization demonstrated that it belonged to the species Streptomyces hygroscopicus. The strain was given the name S. hygroscopicus S-632. These antibiotics were active against Saccharomyces sp., but inactive against filamentous fungi and bacteria, and had cytotoxic activity against KB tissue culture cells.
Otani
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Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan.
Sasaki
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Minami
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Marunaka
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Yu
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QW
D000935:Antifungal Agents / Q000096:biosynthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002473:Cell Wall / Q000032:analysis; D003513:Cycloheximide / Q000494:pharmacology; D003960:Diaminopimelic Acid / Q000032:analysis; D005285:Fermentation; D008855:Microscopy, Electron, Scanning; D010881:Piperidones / Q000096:biosynthesis / Q000494:pharmacology; D012440:Saccharomyces / Q000187:drug effects; D013302:Streptomyces / Q000145:classification* / Q000502:physiology / Q000648:ultrastructure; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D010881:Piperidones; C059802:antibiotic S 632-B1; D003960:Diaminopimelic Acid; D003513:Cycloheximide