[Effectiveness of local delivery of ofloxacin using controlled-release strips (PT-01) in periodontal patients. Part 1. PT-01 application among treatment plans for periodontal disease].
Three different sites which have more than 5 mm pocket were randomly selected in each periodontal patient and were divided into three groups: PT-01 treated site, placebo treated site and control site. After application of either PT-01 or placebo twice for two weeks, subgingval scaling and root planing were performed. Then PT-01 and the placebo were applied weekly to the periodontal pocket for four weeks and clinical and microbiological evaluations were made. The results obtained were as follows: 1. On clinical evaluation, significant improvement was found in the PT-01 treated site in comparison with the placebo treated and/or control site. 2. On microbiological evaluation, slight improvement was found in the PT-01 treated site, whereas there was no significant difference among the three sites.
Ueda
M
M
Teranishi
Y
Y
Kitamura
T
T
Makigusa
K
K
Shirai
T
T
Tanaka
M
M
Higashi
K
K
Ohashi
S
S
Minamibayashi
S
S
Yamaoka
A
A
D003692:Delayed-Action Preparations; D012534:Dental Scaling; D006801:Humans; D015242:Ofloxacin / Q000008:administration & dosage*; D010510:Periodontal Diseases / Q000628:therapy*; D014092:Tooth Root / Q000601:surgery
D003692:Delayed-Action Preparations; D015242:Ofloxacin