title: Classical conditioning leads to changes in extracellular concentrations of ependymin in goldfish brain.
abstract: ELISA measurements showed that brain extracellular fluid (ECF) levels of ependymin decreased for animals that learned to associate a paired presentation of a light stimulus (CS) with the onset of an electric shock (US), whereas no changes were obtained for control goldfish that received the same number of stimuli delivered in a random unpaired order. Studies of the time course of the changes showed an immediate decrease (19%) after training followed by an increase (20%) above baseline by 5 h and a final return to baseline by 25 h. These data extend the findings of previous experiments, which demonstrated a role for ependymin in two training procedures that involved motor learning, to classical conditioning where no motor learning occurs. Thus it appears that ependymin may have a functional role in molecular mechanisms of learning and memory in general.
authors.affiliation: Ralph Lowell Laboratories, McLean Hospital, Harvard Medical School, Belmont, MA 02178.
authors.forename: V E
authors.initials: VE
authors.lastname: Shashoua
authors.forename: G W
authors.initials: GW
authors.lastname: Hesse
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology*; D003530:Cyprinidae / Q000502:physiology*; D006054:Goldfish / Q000378:metabolism / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000502:physiology*
chemical_list: D009419:Nerve Tissue Proteins; C031632:ependymins