title: Local anesthetic intolerance due to metabisulfite.
abstract: The case of a 40-year-old woman with severe edema of the face and neck after the injection of a local dental anesthetic is presented. The reaction is attributed to the presence of sodium metabisulfite, and antioxidant, in the local anesthetic. Both the anesthetic and the sodium metabisulfite gave a delayed positive patch-test response.
authors.affiliation: Department of Medical Research (Dermatology), University Hospital, Katholieke Universiteit Leuven, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Dooms-Goossens
authors.forename: A G
authors.initials: AG
authors.lastname: de Alam
authors.forename: H
authors.initials: H
authors.lastname: Degreef
authors.forename: A
authors.initials: A
authors.lastname: Kochuyt
mesh_terms: D000328:Adult; D000766:Anesthesia, Dental / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects; D009638:Norepinephrine / Q000009:adverse effects; D013447:Sulfites / Q000009:adverse effects*; D014667:Vasopressins / Q000009:adverse effects
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D013447:Sulfites; C041373:lidocaine, norepinephrine, vasopressin drug combination; D014667:Vasopressins; C005200:sodium metabisulfite; D008012:Lidocaine; D009638:Norepinephrine