[Changes in the peripheral blood, liver and spleen during the long-term experimental administration of modified hemoglobin].
The study of chronic toxicity of polymerized hemoglobin solutions (PHb) has demonstrated the relationship between the dose of the solution administered and the level of functional and morphological changes induced in various organs of experimental animals. Lower doses (1.8 g/kg) of PHb had no effect on the values of protein and carbohydrate metabolism, while the high doses (10-15 g/kg) of PHb resulted in the impairment of protein synthesis, morphological changes in the spleen and lymphatic nodes.
Selivanov
E A
EA
Shabalin
V N
VN
Bystrova
I M
IM
Molokovskaia
I E
IE
Rugal'
V I
VI
D000818:Animals; D001769:Blood / Q000187:drug effects*; D001802:Blood Substitutes / Q000633:toxicity*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006454:Hemoglobins / Q000633:toxicity*; D008099:Liver / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D000091402:Prohibitins; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D013154:Spleen / Q000187:drug effects*
D001802:Blood Substitutes; D006454:Hemoglobins; C000717332:Phb protein, rat; D000091402:Prohibitins; C037158:polyhemoglobin; C030939:polyhemoglobin-pyridoxal-5-phosphate; D011732:Pyridoxal Phosphate
Izmeneniia v perifericheskoĭ krovi, pechni i selezenke pri dlitel'nom vvedenii modifitsirovannogo gemoglobina v éksperimente.