title: Anti-thyroid peroxidase antibody activity in sera of patients with systemic lupus erythematosus.
abstract: Although patients with SLE have autoantibodies to thyroid peroxidase (TPO), IgG from sera of SLE patients does not inhibit TPO activities, in contrast with IgG from sera of patients with thyroid disorders. This finding suggests that the specificities of anti-TPO autoantibodies in SLE are different from those in cases of thyroid disorders. These autoantibodies to TPO should be considered when searching for associations between SLE and autoimmune thyroid disorders.
authors.affiliation: Department of Pediatrics, School of Medicine, Chiba University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kohno
authors.forename: N
authors.initials: N
authors.lastname: Naito
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: A
authors.initials: A
authors.lastname: Hoshioka
authors.forename: H
authors.initials: H
authors.lastname: Niimi
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Hosoya
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology*; D005260:Female; D006111:Graves Disease / Q000276:immunology; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D013961:Thyroid Gland / Q000503:physiopathology; D013967:Thyroiditis, Autoimmune / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007453:Iodide Peroxidase