First-derivative UV spectrophotometric assay of domperidone.
Domperidone in pure form and in a number of pharmaceutical formulations (Motilium) has been determined in 0.5-N sulphuric acid by employing first-derivative at 294 nm and zero-order at 284 nm spectrophotometric modes. The results obtained by utilizing the first derivative procedure were 99.98 +/- 0.47, 101.70 +/- 0.53, 101.70 +/- 0.53 and 101.15 +/- 1.23 for the tablets, oral suspension, drops and suppositories respectively. In a similar way the results obtained for the zero order technique were 105.38 +/- 1.01, 101.70 +/- 2.57, 108.56 +/- 1.16 and 102.23 +/- 3.37 in the order. The standard addition method was adopted to evaluate the accuracy of the first derivative spectrophotometric mode.
Mohamed
M E
ME
Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
al-Khamees
H A
HA
al-Awadi
M
M
al-Khamis
K I
KI
D004294:Domperidone / Q000031:analogs & derivatives / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet; D013488:Suppositories; D013535:Suspensions; D013607:Tablets
D013488:Suppositories; D013535:Suspensions; D013607:Tablets; D004294:Domperidone