title: Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p.
abstract: We used molecular genetic techniques and multipoint linkage analyses to locate the gene responsible for cutaneous malignant melanoma-dysplastic nevus. We evaluated 99 relatives and 26 spouses in six families with a predisposition to melanoma. Thirty-four family members had cutaneous malignant melanoma, and 31 of these 34 also had histologically confirmed dysplastic nevi. Twenty-four family members had dysplastic nevi alone. An analysis of the cosegregation of the cutaneous malignant melanoma-dysplastic nevus trait with 26 polymorphic DNA markers on the short arm of chromosome 1 demonstrated the presence of a gene for susceptibility to melanoma. The gene was located between an anonymous DNA marker (D1S47) and the gene locus for pronatrodilatin, a commonly used reference gene (PND), in chromosome band 1p36. The odds were greater than 260,000:1 in favor of linkage at this location.
authors.affiliation: Family Studies Section, National Cancer Institute, Bethesda, Md. 20892.
authors.forename: S J
authors.initials: SJ
authors.lastname: Bale
authors.forename: N C
authors.initials: NC
authors.lastname: Dracopoli
authors.forename: M A
authors.initials: MA
authors.lastname: Tucker
authors.forename: W H
authors.initials: WH
authors.lastname: Clark
authors.forename: M C
authors.initials: MC
authors.lastname: Fraser
authors.forename: B Z
authors.initials: BZ
authors.lastname: Stanger
authors.forename: P
authors.initials: P
authors.lastname: Green
authors.forename: H
authors.initials: H
authors.lastname: Donis-Keller
authors.forename: D E
authors.initials: DE
authors.lastname: Housman
authors.forename: M H
authors.initials: MH
authors.lastname: Greene
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004416:Dysplastic Nevus Syndrome / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D008545:Melanoma / Q000235:genetics*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000235:genetics*