title: [Role of nitrates in the pharmacologic treatment of heart insufficiency].
abstract: Following a brief historical synopsis on the role of nitrates in clinical practice, their intracellular and general mechanisms of action are reviewed, pointing out the current views on the problem of nitrate tolerance. The present indications for nitrate therapy and their future trends are then discussed. Finally, nitrate formulations, doses and routes of administration are presented and the need of their cautions selection is stressed in order to get the last therapeutic result in each particular clinic setting.
authors.forename: A N
authors.initials: AN
authors.lastname: Diogo
mesh_terms: D001775:Blood Circulation / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D009566:Nitrates / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D009566:Nitrates
vernacular_title: O lugar dos nitratos na terapêutica farmacológica da insuficiência cardíaca.