Aminopyrine-N-demethylase activity of rat liver after administration of crude cannabis extract.
The effect of cannabis extract, on the hepatic aminopyrine-N-demethylase activity was studied in rats. Daily administration of cannabis extract for 15 consecutive days increased the aminopyrine-N-demethylase activity which was significant on day 15 post-treatment at 2 and 10 mg/kg doses. At 20 mg/kg, a significant increase was observed from day 7 which continued up to day 15. These findings suggest that cannabis extract can induce hepatic aminopyrine-N-demethylase activity.
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D000633:Aminopyrine N-Demethylase / Q000096:biosynthesis*; D000818:Animals; D002186:Cannabinoids / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D051381:Rats
D002186:Cannabinoids; D000633:Aminopyrine N-Demethylase