[The effects of dopamine and amrinone on myocardial oxygen demand-supply relationship in dogs with coronary artery stenosis].
This study examined the effects of dopamine (DA) and amrinone (AM) on myocardial oxygen demand-supply relationship in coronary artery stenotic areas (40-60% reduction of coronary blood flow by a constrictor) by measuring myocardial oxygen tension (PmO2) after administration of either DA or AM in twelve dogs. The results were as follow; 1) PmO2 showed no significant changes with either DA or AM, but it showed a significant inverse correlation with HR with DA or AM. Thus changes in HR affected the myocardial oxygen balance. 2) AM showed strong coronary vasodilating action in non-stenotic areas and possibly led to 'steal'. 3) Looking at indicators of myocardial ischemia, MAP/HR was significantly correlated with PmO2, and it reflected the myocardial oxygen demand-supply relationship better than RPP or DPTI/TTI. When DA or AM is used in patients with coronary artery disease, both drugs seem to maintain myocardial oxygen balance unless they cause tachycardia. Caution is required in the administration of AM because of the possibility of 'steal'.
Fujigaki
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D000676:Amrinone / Q000627:therapeutic use*; D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism; D004285:Dogs; D004298:Dopamine / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*
D000676:Amrinone; D010100:Oxygen; D004298:Dopamine