Flurbiprofen in post-partum women: plasma and breast milk disposition.
The plasma and milk disposition of flurbiprofen (FB) was assessed in healthy women during the early post-partum period after multiple doses of FB. The results confirmed that a pragmatic study design is an attainable requirement for definitive statements about the excretion of FB in transitional milk. Nine doses of FB (50 mg per dose) were administered during three days. Paired milk and plasma samples were obtained during this period of dosing as well as after the last dose. The plasma data were used to derive an equation, which was then used to simulate cumulative plasma profiles for multiple doses given at unequal time intervals. The observed data corresponded to the simulated cumulative profiles of FB in plasma. The plasma elimination half-life of FB during early lactation was slightly prolonged (mean 4.8 hrs) as compared to reported values for normal adult men. The peak plasma concentrations of FB were comparable to those reported for healthy volunteers. In 10 of 12 women (3-5 days post-partum) the FB concentration in breast milk was less than 0.050 micrograms/ml. In two women the milk concentrations of FB were 0.06, 0.07 and 0.07 micrograms/ml as found in only three samples. We conclude that, on the basis of dose found in milk, FB is safe for women breast feeding their infants in the early post-partum period.
Smith
I J
IJ
Department of Pharmacology, Louisiana State University Medical Center, Shreveport 71130.
Hinson
J L
JL
Johnson
V A
VA
Brown
R D
RD
Cook
S M
SM
Whitt
R T
RT
Wilson
J T
JT
D000328:Adult; D001940:Breast / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005480:Flurbiprofen / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007774:Lactation; D008895:Milk, Human / Q000378:metabolism*; D049590:Postpartum Period; D011247:Pregnancy; D011422:Propionates / Q000493:pharmacokinetics*; D013056:Spectrophotometry, Ultraviolet
D011422:Propionates; D005480:Flurbiprofen