title: The transmission ratio distortion of the th2-haplotype in vivo and in vitro.
abstract: The th2-haplotype is transmitted at low frequencies (less than 0.30) by +/th2 males in normal matings. In the studies described here, the transmission frequency of the th2-haplotype from Rb7/th2 males was determined for normal and delayed matings and in vitro inseminations. The data show the transmission frequency from the two in vivo inseminations to be less than 0.30 and to be statistically equivalent. However, the in vitro transmission frequency (0.80) is significantly greater than either of the in vivo frequencies. The results show that the environment in which fertilization occurs affects the transmission frequency of this specific t-haplotype significantly.
authors.forename: W
authors.initials: W
authors.lastname: Garside
authors.forename: N
authors.initials: N
authors.lastname: Hillman
mesh_terms: D000818:Animals; D005307:Fertilization in Vitro; D006239:Haplotypes; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains