Retinal periphlebitis after hormonal treatment.
Two cases, those of a man and a woman, developed retinal periphlebitis after hormonal treatment for infertility and contraceptives, respectively. Both had a unilateral severe decrease in visual acuity, and a central scotoma and defect in color vision were also present. The fundus had retinal edema, especially of the macula, a hyperemic disc with blurred margins, normal arteries, congested veins, and marked sheathing along the main veins, with retinal hemorrhages in the inferior half of the retina. Fluorescein angiography showed a delayed filling of the veins in the affected retina and late staining of these veins. Since there was severe visual impairment in each case, systemic adrenocorticosteroids were administered, and a rapid improvement in visual acuity occurred. In one patient, a trace Marcus-Gunn sign, a few small paracentral scotomas, and a defect in color vision were permanent sequelae.
Rock
T
T
Department of Ophthalmology, Sackler Faculty of Medicine, Tel-Aviv University, Edith Wolfson Medical Center, Holon, Israel.
Dinar
Y
Y
Romem
M
M
D000328:Adult; D002996:Clomiphene / Q000009:adverse effects*; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D010689:Phlebitis / Q000139:chemically induced*; D012166:Retinal Hemorrhage / Q000139:chemically induced; D012170:Retinal Vein Occlusion / Q000139:chemically induced*; D014792:Visual Acuity / Q000187:drug effects
D003276:Contraceptives, Oral; D002996:Clomiphene