High efficiency of ferricenium salts as radiosensitizers of V79 cells in vitro and the KHT tumor in vivo.
Ferricenium salts (Fc+X-) can act as radiosensitizers of hypoxic cells in vitro and of KHT tumor cells in vivo. Sensitization is manifest by a removal of the shoulder of the hypoxic radiation survival curve in vitro. This results in a dose modification factor (DMF) of 2.0 when measured at a surviving fraction of 0.1, for 10 mumol dm-3 FcPF6. In comparison, little sensitization is seen in air. The toxicity of these metal complexes, but not their radiosensitizing ability, can be decreased by including protein (Bovine serum albumin) in the medium. This may be related to the fact that the ferricenium complexes react readily with nucleophiles to generate OH radicals. Ferricenium trichloracetate, when given at a dose of 200 mg/kg to mice with the KHT tumor gives an enhancement ratio of 1.3.
Joy
A M
AM
Chemistry Department, Imperial College of Science and Technology, London, U.K.
Goodgame
D M
DM
Stratford
I J
IJ
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003131:Combined Modality Therapy; D005260:Female; D005296:Ferrous Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D066298:In Vitro Techniques; D051379:Mice; D008809:Mice, Inbred C3H; D009593:Nitroimidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D012513:Sarcoma, Experimental / Q000532:radiotherapy*
D005296:Ferrous Compounds; D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents