Decrease in plasma volume from intraabdominal trauma in rats.
Intraabdominal surgery tends to lower circulating blood volume by mechanisms unrelated to bleeding. This phenomenon was investigated in chloralose anesthetized rats. Plasma volume was determined with radiolabelled albumin. Animals were subjected to a standardized abdominal trauma, eliciting minimal bleeding and evaporation, and others served as controls. The trauma decreased plasma volume and increased hematocrit significantly, whereas the plasma concentration of labelled albumin followed a similar time course in traumatized animals and in controls. It is concluded that experimental abdominal trauma may decrease blood volume by a loss of fluid with virtually the same albumin concentration as that of plasma.
Akerström
G
G
Department of Anesthesiology and Intensive Care, Sahlgren's Hospital, Göteborg, Sweden.
Lundin
S
S
Lisander
B
B
D000005:Abdomen / Q000601:surgery*; D000007:Abdominal Injuries / Q000503:physiopathology*; D000818:Animals; D008297:Male; D008954:Models, Biological; D010953:Plasma Volume; D051381:Rats; D011919:Rats, Inbred Strains