Management of monoamine oxidase inhibitor-associated insomnia with trazodone.
Monoamine oxidase inhibitors (MAOIs) have been reported to cause or exacerbate insomnia, sometimes requiring discontinuation despite adequate therapeutic response. The authors present a series of 13 cases of MAOI-associated insomnia managed with addition of trazodone. Twelve patients (92%) had an initial positive response, with nine (69%) able to continue on the combination of MAOI and trazodone without intolerable side effects.
Nierenberg
A A
AA
Laboratories for Psychiatric Research, Mailman Research Center, McLean Hospital, Belmont, Massachusetts 02178.
Keck
P E
PE
D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects*; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced* / Q000188:drug therapy; D014196:Trazodone / Q000008:administration & dosage*
D008996:Monoamine Oxidase Inhibitors; D014196:Trazodone