[Physicochemical and toxicologic aspects of partial glycerides as carrier systems for transdermal systems].
Lipid containing carrier systems are increasingly important for an intercellular transport of drugs. Out of the numerous lipids, triglycerides and partial glycerides of medium chain fatty acids have become of particular interest as absorption promoters. Their chemical and physical properties as well as their analysis are described. Being lipids which are endogenous or very similar to those, they are distinguished by a very low oral and dermal toxicity and a good tolerance. Also at mucous membranes no morphological changes occur.
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Abteilung Forschung-Entwicklung-Anwendungstechnik der Hüls AG, Werk Witten.
D000279:Administration, Cutaneous; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004337:Drug Carriers; D005989:Glycerides / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D008055:Lipids
D004337:Drug Carriers; D005989:Glycerides; D008055:Lipids
Physikochemische und toxikologische Aspekte von Partialglyceriden als Wirkstoffträger für Transdermalsysteme.