title: The primary structure of bovine monoamine oxidase type A. Comparison with peptide sequences of bovine monoamine oxidase type B and other flavoenzymes.
abstract: We have isolated cDNA clones believed to encompass the full-length coding sequences for a subunit of bovine monoamine oxidase type A (MAO-A). The clones code for an apoprotein of 527 amino acid residues corresponding to a molecular mass of 59,806 Da. The inferred protein sequences show an overall similarity of 68% with partial amino acid sequences of bovine type B MAO (about 41% of the total sequence), as well as a greater similarity (greater than 90%) with some regions including that for the published sequence of the flavin-binding region. Sequence comparisons indicate that these two forms of MAO are encoded by distinct genes. Comparison of this sequence with other flavoenzymes showed similarity with regions associated with non-covalent flavin-binding sites. Analysis of mRNAs coding for MAO enzymes showed a heterogeneity of transcripts consistent with several different forms of monoamine oxidase.
authors.affiliation: Neurobiologie Cellulaire et Moleculaire, C.R.N.S., Gif-sur-Yvette, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Powell
authors.forename: Y P
authors.initials: YP
authors.lastname: Hsu
authors.forename: W
authors.initials: W
authors.lastname: Weyler
authors.forename: S A
authors.initials: SA
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Salach
authors.forename: K
authors.initials: K
authors.lastname: Andrikopoulos
authors.forename: J
authors.initials: J
authors.lastname: Mallet
authors.forename: X O
authors.initials: XO
authors.lastname: Breakefield
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D008969:Molecular Sequence Data; D008995:Monoamine Oxidase
chemical_list: D008995:Monoamine Oxidase