title: Effects of fish oil capsules in two dosages on blood pressure, platelet functions, haemorheological and clinical chemistry parameters in apparently healthy subjects.
abstract: The effects of a fish oil concentrate with an omega-3 fatty acid content of 42% was determined in two dosages in a double-blind, placebo-controlled study with a parallel group comparison over a period of 5 weeks with 30 healthy subjects. The daily intake chosen was four and eight capsules corresponding to 1.26 or 2.52 g omega-3 fatty acids. Plasma viscosity, erythrocyte rigidity and systolic blood pressure were significantly decreased (p less than 0.01) after a 5-week administration of 2.52 g omega-3 fatty acid daily. The reduction in vitamin E concentration was significant (p less than 0.01) only in the low-dose fish oil group. Lipids and lipoproteins remained unchanged throughout this experiment.
authors.affiliation: Medical Clinic, Department of Internal Medicine III, Homburg/Saar, FRG.
authors.forename: R
authors.initials: R
authors.lastname: Bach
authors.forename: U
authors.initials: U
authors.lastname: Schmidt
authors.forename: F
authors.initials: F
authors.lastname: Jung
authors.forename: H
authors.initials: H
authors.lastname: Kiesewetter
authors.forename: B
authors.initials: B
authors.lastname: Hennen
authors.forename: E
authors.initials: E
authors.lastname: Wenzel
authors.forename: H
authors.initials: H
authors.lastname: Schieffer
authors.forename: L
authors.initials: L
authors.lastname: Bette
authors.forename: S
authors.initials: S
authors.lastname: Heyden
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D001794:Blood Pressure; D001809:Blood Viscosity; D002214:Capsules; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004907:Erythrocyte Deformability; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D010974:Platelet Aggregation
chemical_list: D002214:Capsules; D005395:Fish Oils; D008055:Lipids