Long lasting respiratory depression induced by morphine-6-glucuronide?
We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome. The plasma concentrations of the active metabolite M6G were more than 10 times those normally seen and the half-lives of M6G and morphine were prolonged.
Hasselström
J
J
Department of Clinical Pharmacology, Huddinge Hospital, Karolinska Institute, Sweden.
Berg
U
U
Löfgren
A
A
Säwe
J
J
D002648:Child; D003864:Depression, Chemical; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000150:complications / Q000601:surgery; D006801:Humans; D009022:Morphine Derivatives / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy; D012120:Respiration Disorders / Q000139:chemically induced*
D009022:Morphine Derivatives; C035349:morphine-6-glucuronide; C018108:morphine-3-glucuronide