[Determination of Candida albicans mannan antigen in serum].
An enzyme-linked immunosorbent assay (ELISA) for detection of Candida albicans mannan antigen in sera pretreated with pronase was used for investigation of antigenemia in 3 groups of patients: Group A: No antigen was detected in patients (n = 270), which were under control by a mycological surveillance programme. They were clinically not suspicious of candidosis and had no remarkable mycological findings. Group B: Candida antigen was detected in 13 cases of 158 patients (= 8.2%), which suffered from unclear clinical symptoms. Therefore a mycological laboratory diagnosis was performed yielding no remarkable findings neglecting the positive antigen detection. Group C: Candida antigen was also detected in 9 cases of 64 patients (= 14.0%), which were suspicious of candidosis and/or had remarkable mycological laboratory findings. The difference between the frequency of antigenemia in group B and C was not significant. According to our preliminary experiences the detection of Candida mannan antigen may support the early diagnosis of invasive candidosis. Yet antigen findings should not be separately interpreted but included in all available clinical and mycological results.
Helbig
J H
JH
Blaschke-Hellmessen
R
R
Lück
P C
PC
D000328:Adult; D000946:Antigens, Fungal / Q000097:blood*; D002176:Candida albicans / Q000276:immunology; D002177:Candidiasis / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008351:Mannans / Q000097:blood*
D000946:Antigens, Fungal; D008351:Mannans
Bestimmung von Candida albicans-Mannan-Antigen im Serum.