Ranitidine fails to suppress the growth in vitro of haemopoietic progenitors from human peripheral blood or bone marrow.
Ranitidine was added in various concentrations (25-1600 ng/ml) to clonal assays of haemopoietic progenitors of normal human peripheral blood or bone marrow. Although a significant reduction in colonies forming from granulocyte-macrophage progenitors (CFU-GM) was demonstrated at the lowest drug concentration, no significant growth suppression was seen at higher concentrations. There was no evidence for growth inhibition of either erythroid progenitors (BFU-E) or pluripotent progenitors (CFU-mix) at any of the drug concentrations studied. A direct toxic effect of ranitidine on normal haemopoietic progenitors thus appears an unlikely cause of cytopenias observed during treatment.
Reid
C D
CD
Section of Haematology, Northwick Park Hospital, Harrow, Middlesex, UK.
Kirk
A
A
D001854:Bone Marrow Cells; D002478:Cells, Cultured; D004912:Erythrocytes; D005260:Female; D006098:Granulocytes; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D008264:Macrophages; D008297:Male; D011899:Ranitidine / Q000494:pharmacology*
D011899:Ranitidine