[A new highly active proteolytic myelin enzyme and its possible role in the mechanism of the demyelinating process].
The study of the myelin in the rabbit brain and in biological fluids of patients with multiple sclerosis has revealed the presence of a new highly active proteolytic enzyme. The article describes the physicochemical properties of this enzyme. Its role in the pathogenesis of the demyelinizing process is emphasized: normally being coupled with an inhibitor the enzyme is released as a result of the demyelinizing process and becomes active. This leads to the destruction of myelin proteins. Possible factors of enzyme activation are considered. The authors discuss the significance of differences in the activities depending on the stage of the process and the course of multiple sclerosis.
Savchenko
Iu N
IuN
Zavalishin
I A
IA
Zakharova
M N
MN
Khrustaleva
N A
NA
Khokhlov
A P
AP
D000293:Adolescent; D000328:Adult; D000626:Aminopeptidases / Q000097:blood / Q000134:cerebrospinal fluid / Q000302:isolation & purification*; D000818:Animals; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000201:enzymology*; D009186:Myelin Sheath / Q000201:enzymology*; D011817:Rabbits
D000626:Aminopeptidases
Novyĭ vysokoaktivnyĭ proteoliticheskiĭ ferment mielina i ego vozmozhnaia rol' v mekhanizme demieliniziruiushchego protsessa.