title: Phosphosugars are potent inhibitors of central nervous system inflammation.
abstract: Adoptively transferred allergic encephalomyelitis can be inhibited by various phosphosugars, particularly mannose-6-phosphate. The sugar specificity suggests that inhibition may be due to depletion of lymphocyte cell-surface lysosomal enzymes, which are essential for the passage of lymphocytes across the vascular endothelium and the entry of lymphocytes into the central nervous system parenchyma.
authors.affiliation: Division of Virology and Cellular Pathology, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T.
authors.forename: D O
authors.initials: DO
authors.lastname: Willenborg
authors.forename: C R
authors.initials: CR
authors.lastname: Parish
authors.forename: W B
authors.initials: WB
authors.lastname: Cowden
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006600:Hexosephosphates / Q000627:therapeutic use*; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000201:enzymology / Q000276:immunology; D008297:Male; D008360:Mannosephosphates / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats
chemical_list: D006600:Hexosephosphates; D008360:Mannosephosphates; C027693:mannose-6-phosphate