title: [The effect of diltiazem (Lachema) on transmural non-homogeneity of histochemical changes due to the Ca-paradox].
abstract: Calcium paradox was induced by 2.5 min perfusion of the rat heart (Langedorf's system) at 37 degrees C with calcium-free Krebs--Henseleit solution and subsequent 10 min reperfusion with the same solution containing calcium. Ca2+ depletion itself did not affect the activities of the histochemically studied enzymes (succinate dehydrogenase, lactate dehydrogenase, beta-hydroxybutyric dehydrogenase, phosphorylase, and ATPases). Ca paradox was histochemically characterized by decrease and even disappearance of activities of the given enzymes and by marked transmural nonhomogeneity of these changes exhibiting a decreasing trend towards the endocardium. Diltiazem in the concentration of 0.4 and particularly of 4.0 mumol.l-1 exerted a protective effect manifested by a better preservation of the enzymatic activities.
authors.forename: N
authors.initials: N
authors.lastname: Tribulová
authors.forename: J
authors.initials: J
authors.lastname: Slezák
authors.forename: T
authors.initials: T
authors.lastname: Ravingerová
authors.forename: J
authors.initials: J
authors.lastname: Okolicány
authors.forename: A
authors.initials: A
authors.lastname: Ziegelhöffer
authors.forename: V
authors.initials: V
authors.lastname: Holec
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004110:Diltiazem / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004110:Diltiazem; D002118:Calcium
vernacular_title: Transmurálna nehomogénnost' histochemických zmien po Ca-paradoxe a po jeho ovplyvnení diltiazemom (Lachema).