Estrogens and the pathophysiology of Parkinson's disease.
Two postmenopausal female Parkinsonian patients experienced exacerbation of symptoms including levodopa-induced "On-Off" following withdrawal or reduction of conjugated estrogen therapy. This report supports animal data implicating female sexual hormones in the pathophysiology of Parkinson's disease and levodopa-induced dyskinesias.
Sandyk
R
R
Department of Neurology, University of Arizona, Tucson 85724.
D004967:Estrogens / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology
D004967:Estrogens; D007980:Levodopa