Mechanisms of endogenous nitrosation.
Endogenous formation of N-nitroso compounds has been demonstrated in both humans and experimental animals. The extent of this process has been estimated by measurement of urinary N-nitrosoproline and has been shown to be modulated by dietary precursors and inhibitors. It is now also recognized that other (non-gastric) pathways of endogenous nitrosation, including those catalysed by bacteria and mammalian cells, may exist. The mammalian cell catalysed pathway utilizes arginine as a precursor for the nitrosating agent and may occur in macrophages or endothelial cells. The estimated contribution of this pathway to normal basal endogenous nitrosation is approximately 20 nmol of N-nitrosoproline/day.
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Division of Toxicology, Massachusetts Institute of Technology, Cambridge 02139.
Wishnok
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JS
Tannenbaum
S R
SR
D000818:Animals; D001419:Bacteria / Q000378:metabolism; D004727:Endothelium / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D015538:Nitrosation; D009603:Nitroso Compounds / Q000138:chemical synthesis / Q000378:metabolism*
D009603:Nitroso Compounds