In vitro studies on the invasion of blood vessel wall by choriocarcinoma cells.
The development of metastases represents the lethal event in the clinical course of most neoplastic diseases. The complex mechanism responsible for the spread of cancer are governed by interactions between tumour cells and the host tissues. Choriocarcinoma cells and cultured blood vessels were used to study the interaction between tumour and endothelial cells. Seeding of tumour cells onto blood vessel wall caused retraction of endothelial cells leading to the exposure of underlying tissue. Subsequently, the tumour cells penetrated the sub-endothelial connective tissue and the internal elastic lamina.
Chew
E C
EC
Department of Anatomy, Chinese University of Hong Kong, Shatin, N.T.
Cheung
S L
SL
D000818:Animals; D001808:Blood Vessels / Q000473:pathology*; D002465:Cell Movement; D002822:Choriocarcinoma / Q000473:pathology* / Q000648:ultrastructure; D004730:Endothelium, Vascular / Q000648:ultrastructure; D005260:Female; D006863:Hydrogen-Ion Concentration; D008297:Male; D008854:Microscopy, Electron; D009361:Neoplasm Invasiveness; D051381:Rats