[Antibody formation to autologous erythrocytes following the immunization with rat erythrocytes of normal animals and mice tolerant to the immunizing antigen].
(CBA X C57B1/6)F1 mice immunized three times with rat erythrocytes produced antibodies both to this antigen and to autologous erythrocytes. Most of the antibodies to rat erythrocytes belonged to IgM isotype while antibodies to autologous red cells were of IgG isotype. Combined injection of thymectomized (CBA X C57B1/6)F1 mice with a massive dose of rat spleen cells and cyclophosphamide induced in animals stable tolerance to rat cells. Inducibility of antibodies to autologous red cells in tolerant mice injected 3-5 times with rat erythrocytes was drastically reduced. Nonspecific suppression (thymectomy and cyclophosphamide) did not prevent production of autoantibodies.
Prigozhina
T B
TB
Chulkova
N V
NV
Fontalin
L N
LN
Nagurskaia
E V
EV
Cherniakhovskaia
I Iu
IIu
D000818:Animals; D000941:Antigens / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis / Q000096:biosynthesis*; D003429:Cross Reactions; D004912:Erythrocytes / Q000276:immunology*; D007108:Immune Tolerance; D007114:Immunization / Q000379:methods*; D007074:Immunoglobulin G / Q000032:analysis; D007132:Immunoglobulin Isotypes / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000941:Antigens; D001323:Autoantibodies; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M
Formirovanie antitel k autologichnym éritrotsitam posle immunizatsii éritrotsitami krysy normal'nykh zhivotnykh i mysheĭ, tolerantnykh k immuniziruiushchemu antigenu.