title: New derivatives of 5-nitroimidazole: synthesis and antiparasitic activity.
abstract: The synthesis and the antiparasitic evaluation of twelve new 5-nitroimidaole derivatives has been carried out. The most effective compounds were the less hydrophilic pyridinium and imidazolium salts (IV), (V) and (X), and above all the tetrahydropyridine derivatives (XII) and (XIII).
authors.affiliation: Lab. Quimica Organica, Facultad de Farmacia, Universidad de Barcelona, España.
authors.forename: E
authors.initials: E
authors.lastname: Alcalde
authors.forename: L
authors.initials: L
authors.lastname: Maños
authors.forename: I
authors.initials: I
authors.lastname: Dinares
authors.forename: N
authors.initials: N
authors.lastname: Valls
authors.forename: J
authors.initials: J
authors.lastname: Elguero
authors.forename: J A
authors.initials: JA
authors.lastname: Escario
authors.forename: A R
authors.initials: AR
authors.lastname: Martinez
authors.forename: A
authors.initials: A
authors.lastname: Igea
authors.forename: A
authors.initials: A
authors.lastname: Osuna
authors.forename: L M
authors.initials: LM
authors.lastname: Ruiz-Perez
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis; D000935:Antifungal Agents / Q000138:chemical synthesis; D000962:Antimalarials / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D004747:Entamoeba / Q000187:drug effects; D005872:Giardia / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014244:Trichomonas / Q000187:drug effects; D014246:Trichomonas vaginalis / Q000187:drug effects; D014344:Trypanocidal Agents / Q000138:chemical synthesis
chemical_list: D000871:Anthelmintics; D000935:Antifungal Agents; D000962:Antimalarials; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C052587:4-nitroimidazole