title: Effects of steroid anaesthesia on some liver function tests in goats.
abstract: The effect of Saffan, a steroid anaesthetic, on the liver function of goats has been studied. Forty healthy animals were divided into 4 equal groups. The first 2 groups were given 2 and 4 mg Saffan/kg b. wt respectively. A mixture of Saffan (1 mg) and Xylazine (0.1 mg)/kg b. wt was given to the third group and Xylazine alone to the fourth group (0.1 mg/kg b. wt). Serum samples from all groups were analysed for glucose, total protein, total and direct bilirubin and the level of activity of transaminases. Administration of Saffan evoked more hyperglycemia than a mixture with Xylazine, or Xylazine alone. The hyperglycemic effect of both doses of Saffan (2 and 4 mg) was equivocal beyond 2 h. The effect then differed and glucose was increased 4-fold by 2 mg and 3-fold by 4 mg Saffan. Serum total protein, conjugated and total bilirubin, and GPT and GOT were not changed in the four experimental groups. This was good evidence of a normally functioning liver during the course of steroid anaesthesia administration in goats.
authors.affiliation: Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
authors.forename: H A
authors.initials: HA
authors.lastname: Amer
authors.forename: A S
authors.initials: AS
authors.lastname: Ahmed
authors.forename: H M
authors.initials: HM
authors.lastname: Gohar
authors.forename: M A
authors.initials: MA
authors.lastname: Abdel Mamid
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000530:Alfaxalone Alfadolone Mixture / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D006041:Goats; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D008297:Male; D014991:Xylazine / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D014991:Xylazine; D000530:Alfaxalone Alfadolone Mixture; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin