title: [Adverse effects of drug metaphylaxis of urolithiasis].
abstract: The authors examined 133 patients with urolithiasis, treated with hydrochlorothiazide and 81 patients treated with allopurinol. In those treated with hydrochlorothiazide the calciuria and Ca/creat. index declined, and uricaemia rose. After treatment uricosuria increased significantly in 41% patients. The detection of diabetes did not exceed the prevalence in the population. In patients treated with allopurinol the uricaemia and uricosuria declined, a hepatic disorder with supraliminal rise of ALT was recorded in 23% of the patients and led to discontinuation of treatment in 15% of the patients.
authors.forename: J
authors.initials: J
authors.lastname: Tuíková
authors.forename: R
authors.initials: R
authors.lastname: Kocvara
mesh_terms: D000493:Allopurinol / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects* / Q000627:therapeutic use; D014527:Uric Acid / Q000378:metabolism; D014545:Urinary Calculi / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D006852:Hydrochlorothiazide; D014527:Uric Acid; D000493:Allopurinol
vernacular_title: K nĕkterým nezádoucím úcinkům medikamentózní metafylaxe urolitiázy.