[Clofazimine--therapeutic alternative in necrobiosis lipoidica and granuloma anulare].
Twenty patients, ten suffering from disseminated granuloma anulare and ten from necrobiosis lipoidica, were treated with clofazimine 200 mg p.o. daily. Six patients in each group (60%) responded to this regimen, and three of the responders in each group achieved complete remission of the dermatosis. In eight patients (40%) no improvement at all was observed. All the patients treated had reddening of the skin, but this was reversible after the end of therapy, as were the other side-effects, i.e. diarrhoea and dryness of the skin, which were not experienced by all patients.
Mensing
H
H
Universitäts-Hautklinik Hamburg, Eppendorf.
D000284:Administration, Oral; D000328:Adult; D002991:Clofazimine / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006099:Granuloma / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009335:Necrobiosis Lipoidica / Q000188:drug therapy*; D012008:Recurrence; D012871:Skin Diseases / Q000188:drug therapy*
D002991:Clofazimine
Clofazimine--therapeutische Alternative bei Necrobiosis lipoidica und Granuloma anulare.