title: Antagonistic effects of caffeine and yohimbine in animal tests of anxiety.
abstract: The effect of a combination of caffeine and yohimbine was investigated in the social interaction, elevated plus-maze and punished-drinking tests of anxiety. Caffeine (40 mg/kg i.p.) had anxiogenic-like effects in the social interaction and plus-maze tests. Yohimbine (2.5 mg/kg i.p.) was anxiogenic-like in the plus-maze and displayed anticonflict activity. Unexpectedly, caffeine and yohimbine antagonized each others' effects in the social interaction and elevated plus-maze tests.
authors.affiliation: Department of Pharmacology, School of Pharmacy, University of London, U.K.
authors.forename: H A
authors.initials: HA
authors.lastname: Baldwin
authors.forename: A L
authors.initials: AL
authors.lastname: Johnston
authors.forename: S E
authors.initials: SE
authors.lastname: File
mesh_terms: D000818:Animals; D001007:Anxiety / Q000523:psychology*; D001522:Behavior, Animal / Q000187:drug effects*; D002110:Caffeine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003220:Conflict, Psychological; D004326:Drinking / Q000187:drug effects; D007398:Interpersonal Relations; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011678:Punishment; D051381:Rats; D015016:Yohimbine / Q000037:antagonists & inhibitors / Q000494:pharmacology*
chemical_list: D015016:Yohimbine; D002110:Caffeine