title: Kawasaki disease--the Singapore experience.
abstract: 50 children with Kawasaki disease were seen between September 1983 to March 1988. Their ages ranged from 3 months to 10 years with a mean age of 25 months. Male to Female ratio was 2.3 to 1. The diagnosis of Kawasaki disease was made between the fourth to fifteenth day of illness. Marked thrombocytosis, raised erythrocyte sedimentation rate, leucocytosis, mild anemia and sterile pyuria were common features. All patients had a normal ECG and chest X-ray. 2D echocardiogram was done in the sub-acute phase of the illness in every patient. Sixteen patients (32%) had coronary artery dilatation. Thirteen of these had serial 2D echocardiograms done over a period of more than one year. Twelve had echocardiographic resolution of the coronary lesion within 18 months of follow up. Patients with coronary artery dilatation were significantly younger. All had full clinical recovery with aspirin therapy. Kawasaki disease afflicts mostly young children and can present as a diagnostic problem. Coronary artery involvement is common, and except for age, it is not predictable by any clinical or laboratory parameter. Serial echocardiographic examinations are necessary in the management of these patients.
authors.affiliation: Department of Cardiology, Singapore General Hospital.
authors.forename: M P
authors.initials: MP
authors.lastname: Ng
authors.forename: K Y
authors.initials: KY
authors.lastname: Wong
authors.forename: C L
authors.initials: CL
authors.lastname: Tan
authors.forename: K W
authors.initials: KW
authors.lastname: Tan
mesh_terms: D000367:Age Factors; D001241:Aspirin / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003331:Coronary Vessels / Q000473:pathology; D004108:Dilatation, Pathologic / Q000175:diagnosis; D004452:Echocardiography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D012846:Singapore; D013922:Thrombocytosis / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D001241:Aspirin