title: Effects of hypergravity environment on the parathyroid gland of the isoproterenol-treated hamster.
abstract: The ultrastructure of the parathyroid glands of hamsters subjected to 5 g environment after an intraperitoneal injection of isoproterenol was studied. In the isoproterenol-treated hamsters exposed to hypergravity environment, the Golgi complexes, cisternae of the granular endoplasmic reticulum and lipid droplets were significantly increased and secretory granules were significantly decreased compared with those of the control group. In addition, many chief cells contained numerous prosecretory granules in the Golgi areas and several secretory granules were situated close to the plasma membrane of the chief cells. These results suggest that the synthesis and release of parathyroid hormone may be markedly stimulated in the parathyroid glands of the isoproterenol-treated hamsters exposed to hypergravity environment.
authors.affiliation: Department of Anatomy, Gifu University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shoumura
authors.forename: S
authors.initials: S
authors.lastname: Emura
authors.forename: N
authors.initials: N
authors.lastname: Ishizaki
authors.forename: T
authors.initials: T
authors.lastname: Yamahira
authors.forename: H Y
authors.initials: HY
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Isono
mesh_terms: D000818:Animals; D006224:Cricetinae; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D006112:Gravitation; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008647:Mesocricetus; D008854:Microscopy, Electron; D010280:Parathyroid Glands / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure*
chemical_list: D007545:Isoproterenol