Bicyclic peptides: solution conformation and Ca2+ binding of the heterodetic bicyclic decapeptide cyclo(Glu1-Leu2-Pro3-Gly4-Ser5-Ile6-Pro7-Ala8)- cyclo(1 gamma----5 beta)Phe9-Gly10.
The conformational behavior of a heterodetic bicyclic decapeptide (BCPLT) in the absence and in the presence of calcium ions has been studied by means of mono and two-dimensional nmr techniques. Free BCPLT possesses a quite compact structure stabilized by intramolecular bonds and turns. In the structure a cluster of carbonyls is located in a cavity that is supposed to be the cation binding site.
Zanotti
G
G
Pinnen
F
F
Lucente
G
G
Paolillo
L
L
D'Auria
G
G
Trivellone
E
E
D'Alagni
M
M
D000595:Amino Acid Sequence; D002118:Calcium; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic; D011485:Protein Binding; D011487:Protein Conformation
D010456:Peptides, Cyclic; D002118:Calcium