title: Seasonal variation in responsiveness of human eccrine sweat glands to phenylephrine.
abstract: The responses of eccrine sweat glands to intradermally injected phenylephrine were studied in six healthy male volunteers in two experiments carried out in February and June. Phenylephrine (10(-7)-10(-2) M, 50 microliters) had no consistent effect on sweat gland activity during February, but evoked dose-related increases in sweat gland activity during June. Responsiveness to phenylephrine could be antagonized by prazosin (10(-5) and 10(-4) M) added to the injection solution.
authors.affiliation: Department of Psychiatry, University of Manchester.
authors.forename: W M
authors.initials: WM
authors.lastname: Banjar
authors.forename: C M
authors.initials: CM
authors.lastname: Bradshaw
authors.forename: E
authors.initials: E
authors.lastname: Szabadi
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology*; D011224:Prazosin / Q000494:pharmacology; D012621:Seasons; D013545:Sweat Glands / Q000187:drug effects*; D013546:Sweating / Q000187:drug effects
chemical_list: D010656:Phenylephrine; D011224:Prazosin