title: The effects of iron-mediated oxidative stress in isolated renal cortical brush border membrane vesicles at normothermic and hypothermic temperatures.
abstract: Experiments on renal cortical brush border membrane vesicles have been undertaken in order to assess the involvement of iron in oxidative stress at physiological temperatures and under conditions of hypothermia. A decrease in temperature stimulated iron-induced lipid peroxidation. The results are discussed in relation to the role of the oxidation state of the iron and iron(II)/iron(III) ratios in the initiation of peroxidative events.
authors.affiliation: Department of Biochemistry, Royal Free Hospital School of Medicine, University of London, UK.
authors.forename: R
authors.initials: R
authors.lastname: Horton
authors.forename: C
authors.initials: C
authors.lastname: Rice-Evans
authors.forename: B J
authors.initials: BJ
authors.lastname: Fuller
mesh_terms: D000818:Animals; D003676:Deferoxamine / Q000494:pharmacology; D007035:Hypothermia / Q000378:metabolism*; D007501:Iron / Q000494:pharmacology*; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008871:Microvilli / Q000187:drug effects / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D012016:Reference Values; D013552:Swine; D013696:Temperature
chemical_list: D008054:Lipid Peroxides; D010743:Phospholipids; D007501:Iron; D003676:Deferoxamine