[Effect of a 3-hydroxypyridine-class antioxidant on an ethanol-induced learning disorder in mice and the accumulation of lipofuscin].
Molecular processes of biological aging could interact with molecular effects of ethanol, potentiating each other and culminating in accelerated aging process. According to this premise effect of antioxidant of 3-hydroxypyridine class (3-HP) on behaviour of 3-month-old mice after chronic alcoholisation was investigated. 5-month alcoholisation induced impairment of the process of learning in mice and accelerated accumulation of lipofuscin (age pigment) in the brain. 3-HP consumption (20-25 mg/kg/day in drinking water) during alcoholisation contributed to preservation of learning ability in mice and decreased lipofuscin accumulation in the brain in comparison with alcohol-treated mice. Effect of 3-HP may be due to its antioxidant properties and its ability to increase animals resistance to the extreme factors.
Kutepova
O A
OA
Voronina
T A
TA
Zolotov
N N
NN
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002908:Chronic Disease; D003214:Conditioning, Classical / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D007859:Learning Disabilities / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008062:Lipofuscin / Q000378:metabolism*; D051379:Mice; D010847:Picolines / Q000627:therapeutic use*; D010860:Pigments, Biological / Q000378:metabolism*
D000975:Antioxidants; D008062:Lipofuscin; D010847:Picolines; D010860:Pigments, Biological; D000431:Ethanol; C039550:2-methyl-6-ethyl-3-hydroxypyridine
Vliianie antioksidanta iz klassa 3-oksipiridinov na vyzvannoe étanolom narushenie obucheniia u mysheĭ i nakoplenie lipofustsina.