Quinolone antibacterial agents for the treatment of genitourinary tract infections.
The fluoroquinolones have expanded the therapeutic options available for the treatment of genitourinary tract infections. Their ease of oral administration, favourable pharmacokinetics, low incidence of adverse reactions, and broad spectrum of in vitro activity against aerobic and facultative organisms make them especially suitable for treating bacteriuria, particularly when pathogens are resistant to other available oral agents. Their efficacy has also been established in the treatment of prostatis, gonorrhea and chancroid. They have lower in vitro activity against chlamydia, ureaplasma and anaerobes, and their role in the treatment of non-gonococcal urethritis, vaginitis and acute pelvic inflammatory disease is less well established.
Babinchak
T J
TJ
Ohio State University College of Medicine, Columbus 43210.
Fass
R J
RJ
D042462:4-Quinolones; D000284:Administration, Oral; D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D004755:Enterobacteriaceae / Q000187:drug effects / Q000472:pathogenicity; D006801:Humans; D012749:Sexually Transmitted Diseases / Q000188:drug therapy* / Q000382:microbiology; D014552:Urinary Tract Infections / Q000188:drug therapy*; D014566:Urogenital System / Q000382:microbiology
D042462:4-Quinolones; D000890:Anti-Infective Agents