title: Management of laryngeal radionecrosis: animal and clinical experience.
abstract: Radiation necrosis of the laryngeal cartilages is an uncommon complication of radiotherapy for laryngeal carcinoma. It is a devastating process for which there is no one acceptable treatment. Medical management offers only temporary, symptomatic relief, which further necessitates surgical treatment. Surgical management may start with a tracheotomy; however, it often ends with a total laryngectomy. Physiologically, the necrotic cartilages are the source of the problem. It is a general surgical principle that nonviable tissue must be excised to promote healing. Therefore, if the affected laryngeal cartilages were removed, the larynx should heal. Total or near total removal of the thyroid and cricoid cartilages with preservation of the endolaryngeal soft tissues has not been reported in the literature. Theoretically, if the entire cartilaginous framework is removed, there would be no structural support for the airway. We have found using animal models, that submucosal resection of the laryngeal cartilages, leaving the perichondrium and endolaryngeal soft tissues intact can result in a competent airway. Animal and clinical experience will be presented.
authors.affiliation: Department of Otolaryngology, SUNY-Health Sciences Center, Brooklyn 11203.
authors.forename: R W
authors.initials: RW
authors.lastname: Oppenheimer
authors.forename: Y P
authors.initials: YP
authors.lastname: Krespi
authors.forename: R K
authors.initials: RK
authors.lastname: Einhorn
mesh_terms: D000818:Animals; D003413:Cricoid Cartilage / Q000601:surgery; D004285:Dogs; D006801:Humans; D007817:Laryngeal Cartilages / Q000293:injuries* / Q000601:surgery; D007822:Laryngeal Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009336:Necrosis; D011832:Radiation Injuries / Q000601:surgery*; D011833:Radiation Injuries, Experimental / Q000601:surgery*