title: [Not meningitis but septic shock as the killer in acute meningococcal disease].
abstract: The symptoms and clinical course of meningococcaemia in 14 cases are described; 10 patients died; in one of the four survivors amputations were inevitable for necrosis of hands and feet. The foremost symptoms at the first time that a doctor was contacted were fever, lethargy, petechiae and purpura. The fulminant course is shown by the high number of resuscitation at the time of admission or in the first hours after admission, and by the time between first symptoms and death. The mortality of meningococcaemia is mostly not due to meningitis. Most patients die of septic shock even before signs of meningitis can develop. The early signs of meningococcaemia are not those of meningitis, but those of sepsis. Meningism and headache are rare symptoms. The severest symptoms are fever and lethargy, in combination with petechiae and purpura. The fulminant course of the disease requires immediate admission. Treatment of infection and septic shock may be lifesaving.
authors.forename: G D
authors.initials: GD
authors.lastname: Vos
authors.forename: A
authors.initials: A
authors.lastname: Wiegman
authors.forename: J A
authors.initials: JA
authors.lastname: Romijn
authors.forename: A M
authors.initials: AM
authors.lastname: Meurs
authors.forename: M J
authors.initials: MJ
authors.lastname: Bruins-Stassen
authors.forename: R P
authors.initials: RP
authors.lastname: Bijlmer
authors.forename: J J
authors.initials: JJ
authors.lastname: van Lieshout
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003422:Critical Care; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D008585:Meningitis, Meningococcal / Q000401:mortality; D008589:Meningococcal Infections / Q000401:mortality / Q000628:therapy; D012772:Shock, Septic / Q000209:etiology* / Q000401:mortality / Q000628:therapy
vernacular_title: Niet nekkramp, maar septische shock als schrikbeeld acute meningokokkenziekte.