[Effect of the transfusion of blood and hemoderivatives on the prognosis of colorectal cancer].
In recent years in the literature several investigators described a negative effect of perioperative transfusion of blood and hemoderivatives on the prognosis of malignant tumors. Concerning the patients with colorectal carcinoma operated between 1979 and 1983 at Erlangen University Hospital these results could be proven. We observed a significantly worse 5-year survival rate for patients who received perioperative blood transfusion. However, multivariant analysis in Cox-regression model revealed other factors like tumor stage and localisation responsible for the poorer prognosis. Therefore blood transfusion seems not to have any influence on the prognosis itself. Furthermore we observed a significantly poorer prognosis concerning patients who perioperatively received fresh frozen plasma (FFP). Surprisingly multivariant analysis showed that FFP substitution in contrast to blood transfusion has an own prognostic influence. This difference in prognosis cannot be explained by selection criteria. The mechanism of the negative influence of FFP on the prognosis of colorectal carcinoma remains unclear and is investigated currently in prospective studies.
Hermanek
P
P
Chirurgische Klinik und Poliklinik, Universität Erlangen-Nürnberg.
Guggenmoos-Holzmann
I
I
Schricker
K T
KT
Resch
T
T
Freudenberger
K
K
Neidhardt
P
P
Gall
F P
FP
D000368:Aged; D001802:Blood Substitutes / Q000008:administration & dosage*; D001803:Blood Transfusion; D015179:Colorectal Neoplasms / Q000401:mortality / Q000601:surgery*; D017707:Erythrocyte Transfusion; D006801:Humans; D008875:Middle Aged; D010949:Plasma; D011183:Postoperative Complications / Q000401:mortality*; D011300:Preoperative Care; D011379:Prognosis
D001802:Blood Substitutes
Der Einfluss der Transfusion von Blut und Haemoderivaten auf die Prognose des colorectalen Carcinoms.