Micronodular cirrhosis after thiabendazole.
Hepatotoxicity secondary to the administration of thiabendazole has been rare since this drug was produced in 1964. In 14 of 15 patients reported previously in the literature, severe intrahepatic cholestasis resolved within seven months of the onset of illness. A recent report documented the progression to cirrhosis in a 15th patient. We report the second case of a patient with intrahepatic cholestasis that developed after treatment with thiabendazole and progressed to severe micronodular cirrhosis.
Roy
M A
MA
Department of Gastroenterology, Lahey Clinic Medical Center, Burlington, Massachusetts 01805.
Nugent
F W
FW
Aretz
H T
HT
D001706:Biopsy; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged; D013827:Thiabendazole / Q000009:adverse effects*
D013827:Thiabendazole