[Inderal as a means of preventing damage to vitally important organs in the case of mechanical asphyxiation, accompanied by clinical death].
The effect of mechanical asphyxia and the following resuscitation on the metabolism of the vital organs (brain, heart, liver, and lungs) has been experimentally studied in male rats. It has been shown that excessive activation of lipid peroxidation leading to the damage of membrane structures is one of the key factors causing bioenergetic disturbances. In clinical conditions it is manifested in hyperenzymemia, while in isolated isovolumetrically contracting heart it is manifested in massive enzyme outflow from cardiomyocytes into the coronary duct and reduction of glucose uptake per unit of cardiac work performed. These changes closely correlate with contractility function disturbances both in normal and accelerated heart rate. Preadministration of 0.2 mg/kg propranolol increased survival in the early postasphyxia period, decreased considerably metabolic disturbances in vital organs and improved myocardial contractility.
Dolgikh
V T
VT
Meerson
F Z
FZ
D000818:Animals; D001237:Asphyxia / Q000209:etiology* / Q000517:prevention & control; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D011183:Postoperative Complications / Q000517:prevention & control*; D011433:Propranolol / Q000627:therapeutic use*; D051381:Rats; D012151:Resuscitation
D011433:Propranolol; D010100:Oxygen
Inderal kak sredstvo preduprezhdeniia povrezhdeniĭ zhiznenno vazhnykh organov pri mekhanicheskoĭ asfiksii, soprovozhdaiushcheĭsia klinicheskoĭ smert'iu.