title: Evaluation method for krypton-81m reservoir administration systems.
abstract: Large variations have been reported in counting rates during lung ventilation studies using different 81mKr administration systems and among different patients. A method was set up to determine the activity utilization efficiency (AUE) using various administration systems. For that purpose a simple lung simulator was developed for combination with reservoir administration systems to be tested. It was found that under normal breathing conditions the AUE is 50% using a reservoir system and only 18% in the absence of a reservoir in the administration system. The measured results were confirmed by a mathematic model. The suggested simulator is suitable for use in hospitals and also enables an indirect check on the 81Rb/81mKr generator performance.
authors.affiliation: Department of Physics, Eindhoven University of Technology, The Netherlands.
authors.forename: A G
authors.initials: AG
authors.lastname: Janssen
authors.forename: F H
authors.initials: FH
authors.lastname: van Weeren
authors.forename: J J
authors.initials: JJ
authors.lastname: de Goeij
authors.forename: G P
authors.initials: GP
authors.lastname: Wijnhoven
authors.forename: T J
authors.initials: TJ
authors.lastname: Witsenboer
mesh_terms: D004867:Equipment Design; D005069:Evaluation Studies as Topic; D006207:Half-Life; D006801:Humans; D007727:Krypton Radioisotopes / Q000008:administration & dosage*; D008168:Lung / Q000000981:diagnostic imaging; D008433:Mathematics; D008954:Models, Biological; D008961:Models, Structural; D011876:Radionuclide Generators / Q000295:instrumentation*; D011877:Radionuclide Imaging; D012119:Respiration
chemical_list: D007727:Krypton Radioisotopes