Update of mortality among chemical workers with potential exposure to the higher chlorinated dioxins.
This study provided 2 additional years of follow-up through 1984 for a previously studied cohort of 2192 employees potentially exposed to chlorinated dioxins. A separate analysis was done of the subgroup of 323 workers who had chloracne. No clear evidence was found for a causal association between any cause of death and potential occupational exposures to the higher chlorinated phenols, derivative products, or the chlorinated dioxins. Particular focus was directed at mortality from cancers of the stomach, liver, connective and other soft tissue, nasal and nasopharynx, and the lymphomas. Analyses by various indices of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and hexa- to octachlorinated dioxins did not show deaths from these cancers to have been disproportionately distributed among the workers considered to have had the highest exposures.
Bond
G G
GG
Dow Chemical Company, Department of Epidemiology, Midland, MI 48674.
McLaren
E A
EA
Lipps
T E
TE
Cook
R R
RR
D015331:Cohort Studies; D004147:Dioxins / Q000009:adverse effects*; D006801:Humans; D007536:Isomerism; D008113:Liver Neoplasms / Q000139:chemically induced; D008223:Lymphoma / Q000139:chemically induced; D009303:Nasopharyngeal Neoplasms / Q000139:chemically induced; D009369:Neoplasms / Q000139:chemically induced* / Q000401:mortality; D009669:Nose Neoplasms / Q000139:chemically induced; D009784:Occupational Diseases / Q000139:chemically induced* / Q000401:mortality; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000139:chemically induced; D013329:Structure-Activity Relationship; D014481:United States
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins