New antitumor antibiotic, FR-900462. I. Taxonomy of the producing strain.
A new species of the genus Streptomyces, the proposed name of which is Streptomyces tokashikiensis sp. nov., is described. Soil isolate, strain No. 7124, produces a new antitumor antibiotic FR-900462. The organism is characterized by the presence of spores on the substrate hyphae. Strain No. 7124 is closely related to Streptomyces spiralis in morphological and cultural characteristics, but there are differences in spore surface, growth-permissible temperature, and carbohydrate utilization pattern. Therefore, it was decided to designate strain No. 7124 as a new species within the genus Streptomyces.
Iwami
M
M
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Nakayama
O
O
Terano
H
H
Kohsaka
M
M
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D002473:Cell Wall / Q000032:analysis; D003960:Diaminopimelic Acid / Q000032:analysis; D009930:Organic Chemicals; D013302:Streptomyces / Q000145:classification* / Q000166:cytology / Q000502:physiology
D000903:Antibiotics, Antineoplastic; D009930:Organic Chemicals; C059808:FR 900462; D003960:Diaminopimelic Acid