Vitamin A deficiency and tri-iodothyronine action at the cellular level in the rat.
Young rats were given a diet with or without vitamin A for a period of 7 weeks. In rats on the vitamin A-deficient diet, the formation of tri-iodothyronine (T3) complexes with nuclear proteins was reduced, and Scatchard analysis showed a decreased capacity of nuclear T3 receptors. In these rats, a decrease in growth and a decrease in the activity of lipogenic enzymes (glucose-6-phosphate dehydrogenase, phosphogluconate dehydrogenase and L-malate dehydrogenase) occurred, which could be related to the decreased formation of T3-nuclear protein complexes.
Higueret
P
P
Département Alimentation et Nutrition, Université de Bordeaux I, Talence, France.
Pailler
I
I
Garcin
H
H
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011988:Receptors, Thyroid Hormone / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism*; D014802:Vitamin A Deficiency / Q000201:enzymology / Q000378:metabolism*
D011988:Receptors, Thyroid Hormone; D014284:Triiodothyronine