title: Factors affecting gas transfer across the placenta and the oxygen supply to the fetus.
abstract: The factors that affect placental gas exchange are reviewed, with particular reference to recent measurements of the effect of changes in one or more of these factors on O2 delivery to the fetus and on fetal O2 uptake. Fetal or maternal placental blood flows and blood O2 capacities can be altered by 50% without any major change occurring in fetal O2 uptake: umbilical venous O2 content and fetal O2 delivery fall, but the O2 consumption of the fetus is maintained by increasing the fractional extraction of O2 from the blood. There is evidence that the fetus can also cope with a reduction in blood O2 affinity resulting from replacement of fetal with maternal blood. The critical level of O2 delivery is about 0.6 mmol.min-1.kg-1 in the fetal sheep. When O2 delivery is reduced below this level, by decreasing maternal placental blood flow, raising or lowering fetal haematocrit, decreasing maternal O2 capacity, or decreasing fetal O2 affinity, fetal O2 uptake tends to fall. The resultant tissue hypoxia and inability to maintain oxidative metabolism is reflected in a lowering of arterial blood pH and base excess. Whilst the results of short-term experiments suggest that there exists a large reserve for placental O2 transfer and fetal O2 supply, there is evidence that fetal O2 uptake is more tightly linked to O2 delivery when the latter is reduced for a period of days or weeks. In the long term, restriction of the supply of O2 and nutrients leads to a reduced rate of fetal growth and a reprogramming of tissue development.
authors.affiliation: Department of Physiology, University of Odense, Denmark.
authors.forename: A M
authors.initials: AM
authors.lastname: Carter
mesh_terms: D000818:Animals; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D008431:Maternal-Fetal Exchange; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy
chemical_list: D010100:Oxygen