Effects of buprenorphine on motor activity of the sphincter of Oddi in man.
Buprenorphine, (Temgesic), a N-cyclopropylmethyl derivative of oripavine, is both an agonist and antagonist of morphine. Its effect on the motility of the sphincter of Oddi (SO) in humans have been investigated by endoscopic manometry (EM). Buprenorphine leads to a significant decrease in the amplitude of SO contraction waves without altering other parameters. Thus, it has no morphine-like effect on SO motility, but it does act like a partial antagonist of morphine in reducing the amplitude of SO contraction waves.
Cuer
J C
JC
Service d'Hépato-Gastro-Entérologie, Clermont-Ferrand, France.
Dapoigny
M
M
Ajmi
S
S
Larpent
J L
JL
Lunaud
B
B
Ferrier
C
C
Bommelaer
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater / Q000187:drug effects*; D002047:Buprenorphine / Q000494:pharmacology*; D004386:Duodenum / Q000502:physiology; D004724:Endoscopy; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009803:Sphincter of Oddi / Q000187:drug effects*
D002047:Buprenorphine