[Pathological changes in cartilage of the knees in rabbits immunized with Escherichia coli 0:14].
Pathological changes in the articular cartilage were found in the knees of rabbits immunized with heat-killed Escherichia coli for 8-10 months at significantly higher rate (33.3%, 12 of 36 knees, p less than 0.05) than in those immunized for 1-4 months (17.6%, 6 of 34). Cartilage degeneration showed two types which were pannus invasion at the cartilage-synovial junction, and degeneration at superficial layer of the articular cartilage as seen in rheumatoid arthritis of human. Depositions of immunoglobulin were found in 10 out of 16 knees (62.5%) with the pannus invaded lesion and 5 out of 8 knees (75%) with the degenerated superficial layer of articular cartilage.
Sakai
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N
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000473:pathology*; D002358:Cartilage, Articular / Q000473:pathology*; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000276:immunology*; D005260:Female; D011817:Rabbits