In vitro effect of ivermectin on Pseudoterranova decipiens survival.
Third larval stages (L3) removed from fish fillets, fourth larval stages (L4) raised in in vitro culture, and adults of Pseudoterranova decipiens, collected from grey seal (Halichoerus grypus) stomachs, were exposed to the broad spectrum anthelmintic, ivermectin. L3 and L4 parasites were exposed, in vitro, to 500, 100, 50, 20, 5 and 1 micrograms/ml concentrations of the drug, in culture media. Adult P. decipiens were exposed in vitro to a concentration of 500 micrograms/ml ivermectin, only. Controls consisted of parasites placed in culture media alone or culture media plus drug vehicle. These three developmental stages of P. decipiens were all found to be susceptible to the effects of ivermectin.
Manley
K M
KM
Department of Microbiology, Dalhousie University, Halifax, Nova Scotia, Canada.
Embil
J A
JA
D000818:Animals; D010872:Caniformia / Q000469:parasitology*; D003470:Culture Media; D005393:Fish Diseases / Q000469:parasitology*; D005399:Fishes; D007559:Ivermectin / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D008297:Male; D009348:Nematoda / Q000187:drug effects*; D009349:Nematode Infections / Q000469:parasitology / Q000662:veterinary*; D046048:Seals, Earless / Q000469:parasitology*
D003470:Culture Media; D007559:Ivermectin