The effect of antioxidants on the rejection of Nippostrongylus brasiliensis.
The effect of the antioxidants, butylated hydroxy anisole (BHA) and vitamin E, on the rejection of Nippostrongylus brasiliensis from the small intestine of the rat was investigated. Worm expulsion was inhibited by BHA. Malonyldialdehyde production in the small intestines and free radical generation by peritoneal leucocytes from infected rats were also inhibited by BHA. Vitamin E, although inhibiting malonyldialdehyde production, did not prevent worm expulsion. Significantly, vitamin E was much less effective than BHA at reducing free radical generation by rat leucocytes in response to N. brasiliensis.
Smith
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Department of Zoology, Australian National University, Canberra.
Bryant
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C
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D005260:Female; D005609:Free Radicals; D007107:Immune System / Q000187:drug effects; D007421:Intestine, Small / Q000276:immunology / Q000378:metabolism / Q000469:parasitology; D007962:Leukocytes / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D009349:Nematode Infections / Q000276:immunology* / Q000378:metabolism / Q000469:parasitology; D009559:Nippostrongylus; D010529:Peritoneal Cavity / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D005609:Free Radicals; D014810:Vitamin E; D002083:Butylated Hydroxyanisole; D008315:Malondialdehyde