title: Vasopressin excites neurones located in the dorsal cochlear nucleus of the guinea-pig brainstem.
abstract: The effect of arginine vasopressin (AVP) on neurones in the dorsal cochlear nucleus (DCN) of young guinea-pigs of either sex was investigated in brainstem slices. Most impaled neurones fired in a regular manner, either spontaneously or following a depolarizing current injection. AVP, at concentrations of 10-1000 nM, excited 19/19 neurones from male and 16/19 neurones from female animals. This effect of AVP was concentration-dependent and could be mimicked by the V1 agonist [Phe2,Orn8]VT. Oxytocin was less potent than AVP and a selective V2 agonist, deamino-DAVP, was without effect. Thus, a class of DCN neurones is probably endowed with functional V1 vasopressin receptors. By making use of an antibody raised against the vasopressin-related glycopeptide, dense AVP-like immunoreactivity was found in the DCN of young animals of either sex.
authors.affiliation: Department of Physiology, University Medical Center, Geneva, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Charpak
authors.forename: M
authors.initials: M
authors.lastname: Dubois-Dauphin
authors.forename: M
authors.initials: M
authors.lastname: Raggenbass
authors.forename: J J
authors.initials: JJ
authors.lastname: Dreifuss
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D003056:Cochlear Nerve / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D010121:Oxytocin / Q000494:pharmacology
chemical_list: D001127:Arginine Vasopressin; D010121:Oxytocin