title: [Acute severe myositis due to bezafibrate treatment].
abstract: The second generation fibric acid derivative, bezafibrate (Bezalip, Norlip) is widely used as a hypolipemic agent throughout Europe and Israel. Its side-effects are well documented, and include myositis, which is considered very rare. We report a 55-year-old diabetic woman with hypertension who had mild renal dysfunction (creatinine 2.0 mg/dl) who received 400 mg/d bezafibrate because of combined (Type IIb) hyperlipoproteinemia. She developed acute myositis, with extreme muscle weakness, pain and CPK levels of up to 3500 units. On discontinuation of the drug all clinical and biochemical features ceased and complete cure followed. No other symptoms have appeared during 2 years of followup. The few reports of such cases in the German literature point to a greater prevalence of myositis in those with renal dysfunction. Early diagnosis of bezafibrate-induced myositis is crucial, a discontinuation of the drug results in cure.
authors.forename: D
authors.initials: D
authors.lastname: Yeshurun
authors.forename: N
authors.initials: N
authors.lastname: Dakak
authors.forename: K
authors.initials: K
authors.lastname: Khoury
authors.forename: E
authors.initials: E
authors.lastname: Daher
mesh_terms: D000208:Acute Disease; D001629:Bezafibrate / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy; D007674:Kidney Diseases / Q000150:complications; D008875:Middle Aged; D009220:Myositis / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D001629:Bezafibrate