[L-DOPA interaction with the brain tissue DNA of rats].
The possibility of direct interaction of L-DOPA with DNA isolated from rat brain tissue has been considered. The spectral and viscosity data suggest conformational changes in L-DOPA-treated DNA in conditions excluding the accumulation of L-DOPA oxidation products.
Tret'iak
T M
TM
Biriukov
V N
VN
Smol'ianinova
T I
TI
D000818:Animals; D001483:Base Sequence / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004247:DNA / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D066298:In Vitro Techniques; D007980:Levodopa / Q000378:metabolism / Q000494:pharmacology*; D008970:Molecular Weight; D009690:Nucleic Acid Conformation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D007980:Levodopa; D004247:DNA
Vzaimodeĭstvie L-DOFA s DNK tkani goloovnogo mozga krys.