Antagonistic effects of caffeine and yohimbine in animal tests of anxiety.
The effect of a combination of caffeine and yohimbine was investigated in the social interaction, elevated plus-maze and punished-drinking tests of anxiety. Caffeine (40 mg/kg i.p.) had anxiogenic-like effects in the social interaction and plus-maze tests. Yohimbine (2.5 mg/kg i.p.) was anxiogenic-like in the plus-maze and displayed anticonflict activity. Unexpectedly, caffeine and yohimbine antagonized each others' effects in the social interaction and elevated plus-maze tests.
Baldwin
H A
HA
Department of Pharmacology, School of Pharmacy, University of London, U.K.
Johnston
A L
AL
File
S E
SE
D000818:Animals; D001007:Anxiety / Q000523:psychology*; D001522:Behavior, Animal / Q000187:drug effects*; D002110:Caffeine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003220:Conflict, Psychological; D004326:Drinking / Q000187:drug effects; D007398:Interpersonal Relations; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011678:Punishment; D051381:Rats; D015016:Yohimbine / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D015016:Yohimbine; D002110:Caffeine