title: Structure of conformationally constrained peptides: from model compounds to bioactive peptides.
abstract: The use of backbone conformational constraints has acquired increasing importance in the design and synthesis of structurally restricted agonists and antagonists of bioactive peptides. Here I discuss the preferred conformations of four among the most popular types of such peptide surrogates: (a) Peptides from C alpha, alpha-dialkylated residues, (b) tetrazolyl peptides, (c) (gamma- and delta-) lactam-containing peptides, and (d) thiated peptides. Emphasis is given to conformational energy computations and x-ray diffraction analyses of selected model compounds and analogues of small bioactive peptides such as the formylmethionyl tripeptide chemoattractant and MIF.
authors.forename: C
authors.initials: C
authors.lastname: Toniolo
mesh_terms: D008958:Models, Molecular; D009842:Oligopeptides / Q000138:chemical synthesis; D011487:Protein Conformation
chemical_list: D009842:Oligopeptides