The influence of various amino acids on the extrahepatic bile ducts in newborn mice--an experimental study.
Excess proline in adult animals is associated with extrahepatic biliary hyperplasia. Possible therapeutic application of this amino acid in biliary atresia was postulated. In order to test whether excess proline had an influence on the development of the extrahepatic bile ducts, pregnant mice were injected daily with various amino acids. One day and 1 week after delivery, the extrahepatic bile ducts of the newborn mice were studied and the number of epithelial cells per cross section was determined. Neither proline nor any other amino acid had an influence on the proliferation of extrahepatic bile ducts.
Schier
F
F
Department of Pediatric Surgery, University of Münster, West Germany.
Schier
C
C
Szabo
E
E
D000596:Amino Acids / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D001652:Bile Ducts / Q000166:cytology*; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011392:Proline / Q000494:pharmacology
D000596:Amino Acids; D011392:Proline