Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2).
We screened a human parotid gland cDNA library with mixed synthetic oligonucleotide probes representing a central coding region common to histatins 1 and 3. Sequence analysis of 12 histatin cDNA clones strongly suggests that the histatin protein family is encoded by at least two closely related loci (HIS1 and HIS2) such that histatins 1 and 3 are primary products of HIS1(1) and HIS2(1) alleles, respectively, and that histatins 4-6 are derived from histatin 3 by proteolysis. We present additional data indicating that histatin 2 may represent the non-phosphorylated form of histatin 1.
Sabatini
L M
LM
Department of Medical Genetics, University of Wisconsin, Madison 53706.
Azen
E A
EA
D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D010306:Parotid Gland / Q000032:analysis; D010750:Phosphoproteins / Q000235:genetics / Q000302:isolation & purification; D010766:Phosphorylation; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D012471:Salivary Proteins and Peptides / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D014158:Transcription, Genetic; D000099053:Histidine-Rich Glycoprotein
D010750:Phosphoproteins; D011506:Proteins; D012471:Salivary Proteins and Peptides; D000099053:Histidine-Rich Glycoprotein; D004247:DNA