title: Poly(A) metabolism and aging: a current view.
abstract: Polyadenylation of mRNA is a key step in post-transcriptional control of gene expression. Therefore, age-dependent changes in poly(A) synthesis have to play a crucial role in the course of cellular aging. In this review, the importance of the signal sequence, poly(A), in determining mRNA stability and intracellular distribution of mRNA during aging is discussed.
authors.affiliation: Institut für Physiologische Chemie, Mainz University, F.R.G.
authors.forename: W E
authors.initials: WE
authors.lastname: Müller
authors.forename: R
authors.initials: R
authors.lastname: Wenger
authors.forename: M
authors.initials: M
authors.lastname: Bachmann
authors.forename: D
authors.initials: D
authors.lastname: Ugarković
authors.forename: N C
authors.initials: NC
authors.lastname: Courtis
authors.forename: H C
authors.initials: HC
authors.lastname: Schröder
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D015870:Gene Expression; D011061:Poly A / Q000378:metabolism*; D012333:RNA, Messenger / Q000502:physiology
chemical_list: D012333:RNA, Messenger; D011061:Poly A