Treatment of glioma with intratumoral instillation of autologous lymphocytes.
Autologous lymphocytes were instilled into the tumor in a girl 15 years of age who had presented with a recurrent left frontoparietal astrocytoma 1.5 years after surgery, radiation, and chemotherapy. She had remissions for 5 weeks, 5 months, and 20 months after the first, second, and third instillations, respectively. The usefulness of intratumoral instillation of autologous lymphocytes [or preferably lymphokine activated killer (LAK) cells with interleukin-2 is demonstrated in such recurrent astrocytomas.
Bhagwati
S N
SN
Medical Research Center, Bombay Hospital, India.
D000293:Adolescent; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D017710:Lymphocyte Transfusion; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D014057:Tomography, X-Ray Computed; D014182:Transplantation, Autologous