Cytogenetic analysis of in vitro fertilization (IVF) failures.
Cytogenetic studies were carried out on 150 oocytes obtained in a human in vitro fertilization (IVF) program. Although all cells lacked signs of fertilization at light microscopy, 46 (30.7%) appeared to show cytological evidence of fertilization. At least one-third of these cells (with development arrested before first cleavage) had chromosomal aberrations. An aneuploidy rate of 35% was found in unfertilized oocytes. The results of this study explain some of the fertilization failures and of the failures of postfertilization development.
Pieters
M H
MH
Department of Genetics and Cell Biology, University of Limburg, Maastricht, The Netherlands.
Geraedts
J P
JP
Dumoulin
J C
JC
Evers
J L
JL
Bras
M
M
Kornips
F H
FH
Menheere
P P
PP
D000782:Aneuploidy; D002869:Chromosome Aberrations; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D009865:Oocytes / Q000648:ultrastructure*; D011123:Polyploidy