title: Lineage switch and translocation t(9;11) in acute leukemia.
abstract: A boy with acute lymphoblastic leukemia (ALL) who underwent lineage switch at relapse is reported. The second leukemia was myeloid in nature (acute myeloid leukemia, AML), characterized by predominantly My 9 positive blasts at first and at second relapse. Cytogenetic studies at second relapse revealed the translocation (9;11) (p21;q23) in all examined blasts. This is typical for myelomonocytic leukemia. The nature of the relapse and the occurrence of t(9;11) translocations in acute leukemia are discussed.
authors.affiliation: Department of Pediatrics, University Hospital Gasthuisberg, University of Leuven, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Van Lierde
authors.forename: C
authors.initials: C
authors.lastname: Mecucci
authors.forename: M
authors.initials: M
authors.lastname: Casteels-Van Daele
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000473:pathology*; D014178:Translocation, Genetic