title: Ranitidine-induced chest pain.
abstract: A 45-year-old woman with no history of heart disease twice experienced chest pain after consuming a dose of ranitidine. The chest pain, which lasted about one hour, was substernal, left of midline, dull, and pounding. H2-receptors are present in cardiovascular tissues. Although several studies have not noted an effect of ranitidine on cardiac indices there have been case reports indicating a cardiac effect. There are no reports of chest pain associated with H2-blocker ingestion; however, both bradycardia and hypotension (reported effects) might cause chest pain. A discussion of the possible mechanisms is presented.
authors.affiliation: College of Pharmacy, Ann Arbor, MI 48109.
authors.forename: L A
authors.initials: LA
authors.lastname: Shimp
authors.forename: M A
authors.initials: MA
authors.lastname: Smith
authors.forename: D W
authors.initials: DW
authors.lastname: Wahr
mesh_terms: D002637:Chest Pain / Q000139:chemically induced*; D004381:Duodenal Ulcer / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D011899:Ranitidine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D011899:Ranitidine