Diuretic agents related to indapamide. III--Synthesis and pharmacological activity of N-(4-chloro-3-sulfamoylbenzamido)-1,2,3,4-tetrahydroquinolines and 1,2,3,4-tetrahydroisoquinolines.
A series of N-(4-chloro-3-sulfamoylbenzamido)-1,2,3,4-tetrahydroquinoline++ + (IV-1) and isoquinoline (IV-2) have been synthesized and their diuretic and antihypertensive activities evaluated. While none of the test compounds was found to be provided with antihypertensive properties, most of them displayed a diuretic activity comparable to (IV-2 a) or higher (IV-1 a,b) (IV-2 c) than those of indapamide and clopamide, taken as reference drugs.
Landriani
L
L
Istituto Chimico Farmaceutico e Tossicologico, Università di Milano, Italy.
Barlocco
D
D
Pinna
G A
GA
Demontis
M P
MP
Miele
M
M
Enrico
P
P
Anania
V
V
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003005:Clopamide / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000138:chemical synthesis* / Q000494:pharmacology; D007190:Indapamide / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology
D000959:Antihypertensive Agents; D004232:Diuretics; D007546:Isoquinolines; D013449:Sulfonamides; D003005:Clopamide; D007190:Indapamide