title: Perinatal opiate exposure. Effects on metabolism of xenobiotics and steroids in adult rat liver.
abstract: The effects of perinatal or neonatal morphine exposure on the hepatic steroid and xenobiotic metabolism in adult rats were studied. Early morphine exposure did not affect the 16 alpha-hydroxylation or 5 alpha-reduction of androstenedione in either sex, but decreased the 7 alpha- and 6 beta-hydroxylations in both sexes. Morphine exerted a suppressive effect on the ethoxyresorufin-O-deethylase activity and increased the ethoxycoumarin-O-deethylase activity in both sexes. Morphine exposure did not significantly affect its own N-demethylation or the total cytochrome P-450 content in the liver. Neonatal morphine exposure caused a significant decrease in body and testes weight in the adult male rat. We conclude that the effects of morphine are not confined to sex-differentiated pathways and are similar in both sexes.
authors.affiliation: Department of Medical Nutrition, Karolinska Institute, Huddinge Hospital, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Hansson
authors.forename: B
authors.initials: B
authors.lastname: Näslund
authors.forename: A
authors.initials: A
authors.lastname: Blanck
authors.forename: A
authors.initials: A
authors.lastname: Rane
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001189:Aryl Hydrocarbon Hydroxylases; D001835:Body Weight / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D000072467:Cytochrome P450 Family 2; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D009294:Narcotics / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D039181:Steroid 16-alpha-Hydroxylase; D013256:Steroids / Q000378:metabolism*; D013737:Testis / Q000187:drug effects; D015262:Xenobiotics / Q000378:metabolism*
chemical_list: D009294:Narcotics; D013256:Steroids; D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; C450279:CYP2C11 protein, rat; D000072467:Cytochrome P450 Family 2; D039181:Steroid 16-alpha-Hydroxylase