title: [Lipid peroxidation in the synaptosomal and mitochondrial fractions of separate brain structures in hypoxia].
abstract: The paper studies intensification of lipid peroxide oxidation in separate brain structures (the medulla oblongata, cerebellum, visual and sensomotor cortex), synaptosomal and mitochondrial fractions under hypoxia. It has been established that acute hypoxia increases accumulation of lipid peroxidation (LPO) products, hydroperoxide and malonyl dialdehyde. Intensification of LPO in synaptosomes and mitochondria is more pronounced as compared to the whole structures. Preliminary treatment with antioxidants (vitamin E and ionol) considerably suppressed LPO intensity under both hypoxia and hypoxia with reoxygenation. Intensification of LPO in synaptosomes and mitochondria is suggested to be the key point in structural-functional disturbances of the nervous system under hypoxia and ischemia.
authors.forename: A I
authors.initials: AI
authors.lastname: Dzhafarov
authors.forename: N M
authors.initials: NM
authors.lastname: Magomedov
authors.forename: Kh F
authors.initials: KhF
authors.lastname: Babaev
authors.forename: G Sh
authors.initials: GSh
authors.lastname: Akhmedova
mesh_terms: D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D000860:Hypoxia / Q000378:metabolism* / Q000517:prevention & control; D015227:Lipid Peroxidation / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D014810:Vitamin E; D002084:Butylated Hydroxytoluene
vernacular_title: Perekisnoe okislenie lipidov v sinaptosomal'noĭ i mitokhondrial'noĭ fraktsiiakh otdel'nykh struktur mozga pri gipoksii.