title: The response of normal and failing heart to externally applied vibration in the canine open chest preparation.
abstract: We examined the left ventricular functional response to externally applied vibration using four canine open chest preparations. A sinusoidal 30 Hz vibration (2.7 mm in amplitude) was applied to the ventricular epicardium at each level of propranolol-induced myocardial depression. External vibration in control conditions induced no significant change either in peak left ventricular pressure (LVP) or in stroke volume (SV). With propranolol, 0.1 and 0.3 mg/kg, peak LVP and SV were depressed by the application of external vibration, even though there was no significant change of these values in the nonvibrating condition compared to control. We conclude that the ventricular response to vibration depends on the underlying myocardial viability.
authors.affiliation: First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Koiwa
authors.forename: N
authors.initials: N
authors.lastname: Hoshi
authors.forename: T
authors.initials: T
authors.lastname: Ohyama
authors.forename: T
authors.initials: T
authors.lastname: Takagi
authors.forename: J
authors.initials: J
authors.lastname: Kikuchi
authors.forename: H
authors.initials: H
authors.lastname: Honda
authors.forename: T
authors.initials: T
authors.lastname: Takishima
mesh_terms: D000818:Animals; D004285:Dogs; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D011433:Propranolol / Q000494:pharmacology; D014732:Vibration
chemical_list: D011433:Propranolol