Immunotherapy with dog and cat allergen preparations in dog-sensitive and cat-sensitive asthmatics.
Standardized dog and cat allergen preparations with defined allergen composition were used for immunotherapy (IT) in dog-sensitive and/or cat-sensitive adult patients. Seventeen patients completed 1 year of IT. Eleven patients were treated with dog allergen, five with cat allergen, and one with both dog and cat allergen. The treatment was well tolerated, with increased subjective tolerance. After 3 months of IT there was a significant decrease in conjunctival (p less than .05) and skin sensitivity (p less than .05). Specific IgE decreased significantly within 1 year as assayed by RAST and IgE-crossed radioimmunoelectrophoresis. Specific IgG increased in all patients. The results indicate that IT with potent and standardized dog and cat allergens influence the sensitivity to these allergens.
Bucur
J
J
Medical Dept. Angelholm Hospital, Sweden.
Dreborg
S
S
Einarsson
R
R
Ljungstedt-Påhlman
I
I
Nilsson
J E
JE
Persson
G
G
D000485:Allergens / Q000592:standards / Q000627:therapeutic use*; D000818:Animals; D000918:Antibody Specificity; D002415:Cats / Q000276:immunology*; D003228:Conjunctiva / Q000276:immunology; D004285:Dogs / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D005069:Evaluation Studies as Topic; D006801:Humans; D006967:Hypersensitivity / Q000628:therapy*; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007167:Immunotherapy; D011852:Radioallergosorbent Test; D012882:Skin Tests
D000485:Allergens; D007074:Immunoglobulin G; D007073:Immunoglobulin E