title: Synergy of chymopapain and diatrizoate studied in an experimental model.
abstract: The effect of diatrizoate on the chronic toxicity of chymopapain in the epidural space was studied. Chymopapain was injected epidurally into four monkeys; chymopapain plus diatrizoate meglumine, into four. In 3 months, neither group developed significantly more arachnoiditis than a control group of animals that had received epidural injections of physiologic saline. No synergistic effect of chymopapain and diatrizoate on the meninges was detected.
authors.affiliation: Department of Radiology, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee 53226.
authors.forename: V M
authors.initials: VM
authors.lastname: Haughton
authors.forename: K C
authors.initials: KC
authors.lastname: Ho
authors.forename: C M
authors.initials: CM
authors.lastname: Nguyen
mesh_terms: D000818:Animals; D001100:Arachnoiditis / Q000139:chemically induced; D002917:Chymopapain / Q000633:toxicity*; D003974:Diatrizoate Meglumine / Q000633:toxicity*; D004357:Drug Synergism; D007268:Injections, Epidural; D008252:Macaca fascicularis; D008578:Meninges / Q000187:drug effects
chemical_list: D003974:Diatrizoate Meglumine; D002917:Chymopapain