title: DNA replication studies with coliphage 186. II. Depression of host replication by a 186 gene.
abstract: Using pre-labelling rather than pulse-labelling studies to determine rates of replication, we have shown that coliphage 186 infection is accompanied by a depression in host DNA replication. We have isolated mutants of the phage gene involved and mapped them in the early region of the phage genome. Sequencing the mutants ultimately led us to the identification of the gene that we have named the dhr gene.
authors.affiliation: Scripps Clinic and Medical Foundation, La Jolla, CA 92037.
authors.forename: H
authors.initials: H
authors.lastname: Richardson
authors.forename: J B
authors.initials: JB
authors.lastname: Egan
mesh_terms: D001483:Base Sequence; D002455:Cell Division; D002874:Chromosome Mapping; D003090:Coliphages / Q000235:genetics*; D004261:DNA Replication; D004269:DNA, Bacterial / Q000235:genetics*; D005814:Genes, Viral; D008969:Molecular Sequence Data; D009154:Mutation
chemical_list: D004269:DNA, Bacterial