[The effect of pain caused by multiple trauma on gamma-aminobutyric acid metabolism and the functional condition of animals].
Multiple injury to the bone tissue in rats caused changes of gamma-aminobutyric acid (GABA) metabolism manifested first by activation of its synthesis and then by inhibition of enzymatic inactivation and increase in GABA content in the brain. The initial reaction of the GABA system was attended by a loss of total body and thymus weight, increase in adrenal weight, and bicocculin- and picrotoxin-sensitive hypoalgesia in the tail-flick test. The subsequent changes of GABA-ergic transmission developed during restoration of the animals' functional condition but body weight loss persisted. It is suggested that activation of the GABA system is a defence reaction tending to intensify the inhibition processes and increase the activity of the brain antinociceptive systems.
Ignatov
Iu D
IuD
Andreev
B V
BV
Makarova
E P
EP
Avrunin
A S
AS
D000818:Animals; D001921:Brain / Q000378:metabolism; D008297:Male; D009104:Multiple Trauma / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D010146:Pain / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid
Vliianie bolevogo vozdeĭstviia, vyzvannogo politravmoĭ, na obmen gamma-aminomaslianoĭ kosloty i funktsional'noe sostoianie zhivotnykh.