Does directed exploration influence locomotor activity in a holeboard test?
The effects of three drugs, chosen for their differential effects on directed exploration and locomotion (ethanol, caffeine, and FG 7142), were examined on the locomotor activity of mice in a holeboard apparatus containing either a solid floor or one with four holes in it. The dose-related effect of all three drugs on locomotor activity was not changed by the presence of the holes, although activity was slightly higher when a solid floor was used. The results indicated that the two measures can vary independently and that the directed exploration component (head-dipping) of the holeboard test does not significantly influence the locomotor activity component.
Durcan
M J
MJ
Laboratory of Clinical Studies, NIAAA/DICBR, Bethesda, Maryland 20892.
Lister
R G
RG
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology; D001143:Arousal / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology; D002243:Carbolines / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects
D001067:Appetite Depressants; D002243:Carbolines; D002110:Caffeine; D000431:Ethanol; C035874:FG 7142