A brain-specific transcription activator.
We have identified a DNA binding protein, named BETA, that interacts with the same (B) transcriptional regulatory sequence as the known transcription factor NF-kappa B. BETA is found only in gray matter throughout the brain, and not in a variety of other rat tissues. Two binding sites for BETA are present adjacent to the promoter of the rat proenkephalin gene. Transfection of primary brain cultures that express BETA, with a reporter gene driven by the SV40 promoter linked to BETA DNA binding sites, results in transcriptional activation. We infer that BETA is a brain-specific transcription activator.
Korner
M
M
Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.
Rattner
A
A
Mauxion
F
F
Sen
R
R
Citri
Y
Y
D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004586:Electrophoresis; D004745:Enkephalins / Q000235:genetics; D016328:NF-kappa B; D009474:Neurons / Q000378:metabolism; D011401:Promoter Regions, Genetic; D011498:Protein Precursors / Q000235:genetics; D051381:Rats; D014018:Tissue Distribution; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D004745:Enkephalins; D016328:NF-kappa B; D011498:Protein Precursors; D014157:Transcription Factors; C029992:proenkephalin