The effects of iron-mediated oxidative stress in isolated renal cortical brush border membrane vesicles at normothermic and hypothermic temperatures.
Experiments on renal cortical brush border membrane vesicles have been undertaken in order to assess the involvement of iron in oxidative stress at physiological temperatures and under conditions of hypothermia. A decrease in temperature stimulated iron-induced lipid peroxidation. The results are discussed in relation to the role of the oxidation state of the iron and iron(II)/iron(III) ratios in the initiation of peroxidative events.
Horton
R
R
Department of Biochemistry, Royal Free Hospital School of Medicine, University of London, UK.
Rice-Evans
C
C
Fuller
B J
BJ
D000818:Animals; D003676:Deferoxamine / Q000494:pharmacology; D007035:Hypothermia / Q000378:metabolism*; D007501:Iron / Q000494:pharmacology*; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008871:Microvilli / Q000187:drug effects / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D012016:Reference Values; D013552:Swine; D013696:Temperature
D008054:Lipid Peroxides; D010743:Phospholipids; D007501:Iron; D003676:Deferoxamine