title: Localization and structure of the muscarinic receptor ligand binding site.
abstract: A conserved aspartic acid residue in transmembrane helix 3 of the muscarinic acetylcholine receptors is important in binding the headgroup of muscarinic ligands. This acidic amino acid probably points into a relatively hydrophilic cavity whose walls are formed by the amphipathic transmembrane helices of the receptor. Amino acid side chains within this cavity contribute to ligand binding.
authors.forename: E C
authors.initials: EC
authors.lastname: Hulme
authors.forename: C A
authors.initials: CA
authors.lastname: Curtis
authors.forename: M
authors.initials: M
authors.lastname: Wheatley
authors.forename: A
authors.initials: A
authors.lastname: Aitken
authors.forename: A C
authors.initials: AC
authors.lastname: Harris
mesh_terms: D001665:Binding Sites; D006801:Humans; D008024:Ligands; D011976:Receptors, Muscarinic / Q000032:analysis* / Q000235:genetics
chemical_list: D008024:Ligands; D011976:Receptors, Muscarinic