Effect of oral activated charcoal on quinine elimination.
The effect of repeated dose oral activated charcoal on quinine elimination has been studied following a therapeutic (600 mg) dose of quinine bisulphate to seven normal volunteers. Activated charcoal lowered quinine half-life from 8.23 +/- 0.57 s.d. h to 4.55 +/- 0.15 s.d. h (P less than 0.001) and increased its oral clearance by 56%. Activated charcoal may have a role in the management of quinine poisoning.
Lockey
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Wolfson Unit of Clinical Pharmacology, The University, Newcastle upon Tyne.
Bateman
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DN
D000284:Administration, Oral; D000328:Adult; D002606:Charcoal / Q000008:administration & dosage*; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D011803:Quinine / Q000493:pharmacokinetics* / Q000506:poisoning; D012016:Reference Values
D002606:Charcoal; D011803:Quinine