title: Sensitization to Kathon CG in Geneva and Switzerland.
abstract: Between October 1986 and June 1987 we patch tested 420 patients with Kathon CG at 100 ppm and obtained 23 positive reactions (5.5%). The other 5 Swiss university clinics joined our study between January and June 1987 and obtained sensitization rates ranging from 0.7 to 7.5%. The total mean value including Geneva was 3.6%. We did threshold patch testing in 12 patients with the following Kathon CG dilutions: 100, 50, 25, 15 and 7 ppm. We observed progressively diminishing skin reactions, especially below 25 ppm, but we still obtained slight positive reactions in 2 patients with Kathon CG at 7 ppm. Those reactions were relevant because the dermatitis disappeared when the use of Kathon-containing creams was discontinued.
authors.affiliation: Clinique de Dermatologie, Hôpital Cantonal Universitaire, Genève, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Pasche
authors.forename: N
authors.initials: N
authors.lastname: Hunziker
mesh_terms: D000328:Adult; D000368:Aged; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010592:Pharmaceutic Aids / Q000009:adverse effects*; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D013557:Switzerland; D013844:Thiazoles / Q000009:adverse effects*
chemical_list: D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical; D013844:Thiazoles; C037057:Kathon 886