[Effect of trimecaine and its quaternary derivative G-103 on myocardial action potentials].
The conventional microelectrode technique was used to study the effects of trimecaine and its quaternary derivative G-103 on the action potential in the rat myocardium. G-103 suppressed the maximal rate of the action potential depolarization at lower concentrations than trimecaine although its effect developed slower: t 1/2 = 25 and 5 min, respectively. G-103 abolished the tonic component of trimecaine-induced blockade and failed to alter the rate-dependent component.
Sosunov
E A
EA
Balashov
V P
VP
Kostin
Ia V
IaV
Gendenshteĭn
E I
EI
D000083:Acetanilides / Q000031:analogs & derivatives*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D014288:Trimecaine / Q000031:analogs & derivatives* / Q000494:pharmacology
D000083:Acetanilides; D014288:Trimecaine
Vliianie trimekaina i ego chetvertichnogo proizvodnogo Zh-103 na potentsial deĭstviia miokarda.