Alteration in autonomic function and cardiovascular regulation in amyotrophic lateral sclerosis.
Autonomic function mediating cardiovascular regulation was evaluated in amyotrophic lateral sclerosis (ALS) in comparison with Shy-Drager syndrome. The subjects were 14 normal controls and 9 patients each with ALS and Shy-Drager syndrome. To evaluate the autonomic function in detail, a new series of quantitative autonomic function tests was conducted, in conjunction with conventional tests. In patients with ALS, the data indicated subclinical sympathetic hyperfunction and parasympathetic (vagal) hypofunction, probably resulting in cardiovascular dysfunction.
Chida
K
K
Department of Neurology, Nihon University School of Medicine, Tokyo, Japan.
Sakamaki
S
S
Takasu
T
T
D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications* / Q000503:physiopathology; D001285:Atropine / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D001342:Autonomic Nervous System Diseases / Q000150:complications*; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D012791:Shy-Drager Syndrome / Q000150:complications* / Q000503:physiopathology; D014630:Vagus Nerve / Q000503:physiopathology
D001285:Atropine; D007545:Isoproterenol