title: Idiopathic acquired generalized anhidrosis: electron-microscopic and immunohistochemical studies and analysis of lectin-binding pattern of the cell membrane.
abstract: Idiopathic acquired generalized anhidrosis with sudden onset is rare and its pathogenesis is not known. We report a patient with this condition, and the results of electron-microscopic and immunohistochemical studies as well as an analysis of the lectin-binding pattern of the cell membrane. Electron-microscopically, the cells of the eccrine sweat gland showed vacuolar changes. Besides their cytoplasmic changes, the results of a deficient lectin-binding pattern of the glandular cells suggest that there are disturbances in the formation of glycoproteins on their membrane.
authors.affiliation: Tohoku University School of Medicine, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Terui
authors.forename: Y
authors.initials: Y
authors.lastname: Ohkawa
authors.forename: H
authors.initials: H
authors.lastname: Tagami
mesh_terms: D000328:Adult; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007007:Hypohidrosis / Q000473:pathology*; D007150:Immunohistochemistry; D037102:Lectins / Q000378:metabolism; D008854:Microscopy, Electron; D011975:Receptors, Mitogen / Q000032:analysis; D012867:Skin / Q000648:ultrastructure; D014617:Vacuoles / Q000648:ultrastructure
chemical_list: D037102:Lectins; D011975:Receptors, Mitogen