title: Control of G2 delay by the rad9 gene of Saccharomyces cerevisiae.
abstract: In response to DNA damage, Saccharomyces cerevisiae cells arrest the cell cycle in the G2 phase. Arrest is defective in rad9 mutants; rad9 cells divide and die without repairing the damage. Several cell cycle mutants that are defective in DNA replication arrest in G2 at the restrictive temperature; this arrest is due to the RAD9 control function. Thus RAD9 is responsible for the fact that mitosis is normally dependent upon DNA replication, a function we term a 'checkpoint'. Four additional genes have been identified that are also components of the RAD9 checkpoint.
authors.affiliation: Department of Genetics, University of Washington, Seattle 98195.
authors.forename: T
authors.initials: T
authors.lastname: Weinert
authors.forename: L
authors.initials: L
authors.lastname: Hartwell
mesh_terms: D004249:DNA Damage; D004261:DNA Replication; D004271:DNA, Fungal; D005800:Genes, Fungal; D007399:Interphase; D008938:Mitosis; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000528:radiation effects
chemical_list: D004271:DNA, Fungal