[Usefulness of biological tumor markers for early detection of neoplastic changes in the bladder of persons exposed to aromatic amines].
Industrial exposure to aromatic amines may result in bladder cancer, especially in persons characterized by a slow acetylation phenotype. What is particularly important in neoplastics therapies is an early detection of neoplastic changes. Prophylactic and prognostic examination suggest that determination of neoplastic markers may contribute to an early detection of these changes. From the results gathered it emerges that carcinoembryonal antigen (CEA) and tissue polypeptide antigen (TPA) are most useful for an early detection of bladder cancer. It seems reasonable to examine the most seriously exposed ones using methods for CEA and TPA determination. Such an examination performed twice or three times in this group should help to early detect hyperplasia of urinary bladder epithelium.
Hanke
J
J
Instytutu Medycyny Pracy.
Krajewska
B
B
Lutz
W
W
D000328:Adult; D000368:Aged; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D000588:Amines / Q000009:adverse effects*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D002617:Chemical Industry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D010455:Peptides / Q000032:analysis*; D011044:Poland; D013997:Time Factors; D019396:Tissue Polypeptide Antigen; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology
D000395:Air Pollutants, Occupational; D000588:Amines; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D010455:Peptides; D019396:Tissue Polypeptide Antigen
Przydatność biomarkerów nowotworowych dla wczesnej detekcji zmian rakowych w pecherzu moczowym osób esponowanych na aminy aromatyczne.