title: Cerebral lesions in mice infected with Plasmodium berghei are the result of an immunopathological reaction.
abstract: Cerebral lesions in mice with Plasmodium berghei infections can be prevented by timely treatment with immune serum, by splenectomy, and by administration of dexamethasone. T cell deficient mice do not develop cerebral lesions. The results of these studies are compatible with the hypothesis that a pathological reaction is responsible for development of cerebral lesions in mice infected with P. berghei.
authors.affiliation: Department of Cytology and Histology, Catholic University of Nijmegen, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Schetters
authors.forename: J
authors.initials: J
authors.lastname: Curfs
authors.forename: A
authors.initials: A
authors.lastname: van Zon
authors.forename: C
authors.initials: C
authors.lastname: Hermsen
authors.forename: W
authors.initials: W
authors.lastname: Eling
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D001921:Brain / Q000276:immunology / Q000473:pathology; D001927:Brain Diseases / Q000276:immunology* / Q000473:pathology; D008288:Malaria / Q000276:immunology* / Q000473:pathology; D051379:Mice; D010962:Plasmodium berghei / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D000953:Antigens, Protozoan; D014409:Tumor Necrosis Factor-alpha