title: Structure elucidation of ficellomycin.
abstract: The structure of ficellomycin, an antibiotic previously discovered by Argoudelis et al., is elucidated as valyl-2-[4-guanidyl-1-azabicyclo[3.1.0]hexan-2-yl]glycine (1) by NMR, MS, and derivatization studies. The 1-azabicyclo[3.1.0]hexane moiety in 1 represents an unusual ring system making ficellomycin a unique natural product compound.
authors.affiliation: Research Laboratories, Upjohn Company, Kalamazoo, Michigan 49001.
authors.forename: M S
authors.initials: MS
authors.lastname: Kuo
authors.forename: D A
authors.initials: DA
authors.lastname: Yurek
authors.forename: S A
authors.initials: SA
authors.lastname: Mizsak
mesh_terms: D000900:Anti-Bacterial Agents; D055598:Chemical Phenomena; D002621:Chemistry; D036341:Intercellular Signaling Peptides and Proteins; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010455:Peptides
chemical_list: D000900:Anti-Bacterial Agents; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C013532:ficellomycin