title: Endoscopic sclerosis of the cardia affects gastroesophageal reflux.
abstract: Gastroesophageal reflux disease remains a disorder of unknown etiology associated with abnormal function of the lower esophageal sphincter (LES) and other physiological co-factors of the pathologic reflux. Effective operations for reflux are designed to reinforce the anti-reflux barrier and alter the tendency towards abnormal reflux. We have postulated that the most important component of these procedures is the prevention of distraction of the lowermost components of the LES at the onset of a potential reflux episode. Distraction of the LES causes shortening of the effective sphincter mechanism and can initiate experimental reflux events. In this study we used endoscopic sclerosis of the submucosal space at the cardia as a means of reducing distraction of the cardia in the hope that this would reduce abnormal reflux events. Canine gastroesophageal reflux was induced by intravenous atropine and monitored by continuous esophageal pH monitoring. Sclerosis of the cardia prevented gastroesophageal reflux, without measurable effect on the LES pressure or length. Endoscopic sclerosis of the cardia may be a useful technique in the control of human gastroesophageal reflux.
authors.affiliation: Department of Surgery, Cook County Hospital, Chicago, Illinois 60612.
authors.forename: P E
authors.initials: PE
authors.lastname: Donahue
authors.forename: P
authors.initials: P
authors.lastname: Carvalho
authors.forename: J
authors.initials: J
authors.lastname: Yoshida
authors.forename: I
authors.initials: I
authors.lastname: Miidla
authors.forename: Y J
authors.initials: YJ
authors.lastname: Shen
authors.forename: C T
authors.initials: CT
authors.lastname: Bombeck
authors.forename: L M
authors.initials: LM
authors.lastname: Nyhus
mesh_terms: D000818:Animals; D002299:Cardia; D004285:Dogs; D004943:Esophagogastric Junction / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000517:prevention & control*; D012597:Sclerosing Solutions / Q000627:therapeutic use*; D012976:Sodium Morrhuate / Q000627:therapeutic use
chemical_list: D012597:Sclerosing Solutions; D012976:Sodium Morrhuate