title: Effects of traxanox sodium on blood pressure and serum uric acid in hypertensive patients: a preliminary study.
abstract: The effects of chronic administration of traxanox sodium (traxanox) on blood pressure and serum uric acid level were investigated in 15 patients who had mild to moderate hypertension. Traxanox or its placebo was orally administered in a single-blind protocol. Blood pressure was significantly reduced from baseline after treatment with traxanox. The serum uric acid level after drug administration was significantly lower than with placebo whereas urinary uric acid excretion was significantly greater and uric acid clearance tended to be greater. These results indicate that chronic administration of traxanox reduces serum uric acid level as well as blood pressure in patients with mild to moderate hypertension. This reduction in serum uric acid is due in part to a traxanox-induced elevation of urinary uric acid excretion.
authors.affiliation: Department of Clinical Pharmacology, Oita Medical School, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Fujimura
authors.forename: A
authors.initials: A
authors.lastname: Ebihara
authors.forename: N
authors.initials: N
authors.lastname: Hino
authors.forename: Y
authors.initials: Y
authors.lastname: Koike
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002867:Chromones / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use*; D004573:Electrolytes / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014527:Uric Acid / Q000097:blood*; D014563:Urodynamics / Q000187:drug effects
chemical_list: D002867:Chromones; D004232:Diuretics; D004573:Electrolytes; D014527:Uric Acid; C020178:traxanox