Glutathione in Tetrahymena thermophila.
In Tetrahymena, glutathione is synthesized from the same precursors as it is in higher animals and is present in similar intracellular concentrations. The intracellular thiol-disulfide ratio is also identical to that of mammalian tissues, due to the activity of glutathione reductase. The intracellular GSH-level was found to be dependent on the sulfur-containing amino acids in the chemically defined medium.
Wagner
B
B
Institute of Biochemistry, University of Heidelberg, Federal Republic of Germany.
D000818:Animals; D003553:Cystine / Q000494:pharmacology; D003593:Cytoplasm / Q000032:analysis; D005978:Glutathione / Q000032:analysis* / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D008715:Methionine / Q000494:pharmacology; D013768:Tetrahymena / Q000032:analysis* / Q000187:drug effects / Q000201:enzymology
D003553:Cystine; D008715:Methionine; D005980:Glutathione Reductase; D005978:Glutathione