title: Postoperative changes in lipid profile: their relations with inflammatory markers and endocrine mediators.
abstract: Postoperative changes in plasma lipid profile have been studied in six patients undergoing aortobifemoral bypass. The second day after surgery, significant changes were: decreased levels of high density lipoprotein (HDL) cholesterol (by 55%), non HDL cholesterol (by 60%) phospholipid (by 50%), pre-beta-lipoprotein (by 70%), beta-lipoprotein (by 50%), apolipoprotein A1 (by 60%) and apolipoprotein B (by 55%). The magnitude of these changes correlated positively with serum levels of transferrin and negatively with serum levels of C-reactive protein. Triglyceride levels also showed a significant decrease (by 60%) while free fatty acids increased by 70%. Changes in triglyceride levels were not correlated with serum transferrin and C-reactive protein but showed a significant negative correlation with insulin levels. Our results suggest that both inflammatory and endocrine mediators are likely implicated in the postoperative changes in lipid profile.
authors.affiliation: Department of Anesthesiology, University Hospital of Liège, Belgium.
authors.forename: J L
authors.initials: JL
authors.lastname: Canivet
authors.forename: P
authors.initials: P
authors.lastname: Damas
authors.forename: J
authors.initials: J
authors.lastname: Buret
authors.forename: M
authors.initials: M
authors.lastname: Lamy
mesh_terms: D015415:Biomarkers / Q000097:blood; D001807:Blood Vessel Prosthesis; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D011184:Postoperative Period; D014168:Transferrin / Q000032:analysis
chemical_list: D015415:Biomarkers; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D008055:Lipids; D008074:Lipoproteins; D010743:Phospholipids; D014168:Transferrin; D002097:C-Reactive Protein; D002784:Cholesterol