title: Sensitivity of bone histomorphometry in the diagnosis of metabolic bone diseases.
abstract: Diagnostic sensitivity of bone histomorphometry was assessed in different metabolic bone diseases, after fixing the specificity at 75%, 90% and 95% reference levels. Sensitivity was particularly high in cases with greatly increased osteoid and/or resorption features, as in renal osteodystrophy (ROD). All the remodeling indicators were highly sensitive toward advanced or severe forms of mixed ROD (mROD). Osteoid indicators were the most sensitive parameters in ROD with predominant osteomalacia (oROD). Osteoclastic and several osteoid indicators were very sensitive in all grades of ROD with predominant hyperparathyroidism (hROD). Sensitivity was generally low in uremic patients without bone changes (wROD) and also in patients with idiopathic osteoporosis (OP). It is our recommendation, however, that for each individual patient the definite diagnosis should be based on both morphological, clinical and metabolic parameters.
authors.affiliation: Department of Human Biopathology, La Sapienza University of Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Ballanti
authors.forename: C
authors.initials: C
authors.lastname: Della Rocca
authors.forename: E
authors.initials: E
authors.lastname: Bonucci
authors.forename: S
authors.initials: S
authors.lastname: Milani
authors.forename: V
authors.initials: V
authors.lastname: Lo Cascio
authors.forename: B
authors.initials: B
authors.lastname: Imbimbo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology; D000704:Analysis of Variance; D001851:Bone Diseases, Metabolic / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000473:pathology; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000473:pathology; D010024:Osteoporosis / Q000473:pathology; D012016:Reference Values; D012044:Regression Analysis; D012680:Sensitivity and Specificity