[Monoclonal anti-HIV antibodies in HIV/AIDS research. Diagnosis and therapy].
It will be given an overview on several aspects of structure proteins of the HIV and monoclonal antibodies against these. Monoclonal antibodies (mabs) are helpful in research on structure of the virus and pathogenesis of AIDS. A lot of mabs from mice to env, gag and pol gene products has been established. Published human mabs were directed to gp41 and p25 structures of HIV. In future mabs could be used as helpful therapeutical agents especially as immunotoxins against infected cells or as vaccines in form of antiidiotypic mabs.
Giese
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R
Institut für Medizinische Immunologie des Bereichs Medizin, Humboldt-Universität zu Berlin.
Grunow
R
R
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000628:therapy*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000090266:Chromobox Protein Homolog 5; D005814:Genes, Viral; D006678:HIV / Q000235:genetics / Q000276:immunology*; D015483:HIV Antibodies / Q000276:immunology*; D015488:HIV Antigens / Q000276:immunology*; D006679:HIV Seropositivity / Q000175:diagnosis; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D051379:Mice; D012191:Retroviridae Proteins / Q000276:immunology
D000911:Antibodies, Monoclonal; C000715594:CBX5 protein, human; D015483:HIV Antibodies; D015488:HIV Antigens; D007130:Immunoglobulin Idiotypes; D012191:Retroviridae Proteins; D000090266:Chromobox Protein Homolog 5
Monoklonale Anti-HIV Antikörper in der HIV/AIDS-Forschung. Diagnostik und Therapie.