Zidovudine antagonizes the action of pyrimethamine in experimental infection with Toxoplasma gondii.
The effect of zidovudine (azidothymidine; AZT) on the action of pyrimethamine against Toxoplasma gondii was investigated. Zidovudine was found to antagonize the toxoplasmacidal effect of low concentrations of pyrimethamine in vitro, and in vitro synergism of pyrimethamine and sulfadiazine against T. gondii was reversed by zidovudine. Zidovudine also antagonized the therapeutic effect of pyrimethamine in mice acutely infected with T. gondii.
Israelski
D M
DM
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, Palo Alto, California 94301.
Tom
C
C
Remington
J S
JS
D000818:Animals; D002478:Cells, Cultured; D004347:Drug Interactions; D005260:Female; D005347:Fibroblasts; D006801:Humans; D008297:Male; D051379:Mice; D011739:Pyrimethamine / Q000037:antagonists & inhibitors*; D012867:Skin / Q000166:cytology; D014122:Toxoplasma / Q000187:drug effects*; D014124:Toxoplasmosis, Animal / Q000188:drug therapy; D015215:Zidovudine / Q000494:pharmacology*
D015215:Zidovudine; D011739:Pyrimethamine