[The vascular response of spontaneously hypertensive and normotensive rats with diabetes mellitus].
Streptozotocin-induced diabetes caused an increase in AP and reactivity to noradrenaline in perfused caudal artery of normotensive rats (WKY). In spontaneously hypertensive rats (SHR) diabetes led to an increase in reactivity not only to noradrenaline but also to alpha 1-agonist phenylephrine; a response to endothelium-dependent agent acetylcholine was decreased. Alterations in function of the vascular endothelium may be one of the factors causing elevation of vasoconstriction in diabetes mellitus.
Storozhevykh
T P
TP
Zadkova
G F
GF
Markov
Kh M
KhM
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001794:Blood Pressure; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000502:physiology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D012621:Seasons; D014661:Vasoconstriction / Q000187:drug effects
D010656:Phenylephrine; D000109:Acetylcholine; D009638:Norepinephrine
Sosudistye reaktsii spontanno gipertensivnykh i normotenzivnykh krys pri sakharnom diabete.