title: Effect of timolol on the amplitude and dynamics of accommodation.
abstract: There is still debate about whether the ciliary muscle is innervated by the sympathetic nervous system. We investigated the amplitude and the dynamics of accommodation under influence of the non-selective beta-blocker timolol. For this purpose the variations in thickness of the human lens during step-like changes in accommodation were measured with high-resolution A-scan echography. Results showed that the dynamics of accommodation, expressed in the time constants of the response, were affected as well as the amplitude.
authors.affiliation: Department of Medical Physics, Free University, Amsterdam, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Weber
authors.forename: A E
authors.initials: AE
authors.lastname: Tuinenburg
authors.forename: G L
authors.initials: GL
authors.lastname: van der Heijde
mesh_terms: D000065:Accommodation, Ocular / Q000187:drug effects* / Q000502:physiology; D000328:Adult; D002924:Ciliary Body / Q000294:innervation*; D006801:Humans; D007908:Lens, Crystalline / Q000033:anatomy & histology / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D013999:Timolol / Q000494:pharmacology*; D014463:Ultrasonography
chemical_list: D013999:Timolol