Physiological doses of epinephrine in the human: chronotropic but not hyperglycemic or catecholaminotropic.
Single physiological doses of epinephrine did not affect the blood sugar level of human volunteers though they caused a marked tachycardia that was accompanied by a strong transient sensation, typically described as fullness in the chest. Epinephrine did not cause the release of norepinephrine and/or dopamine in man, in contrast to three other vertebrates (lamprey, eel, and rat). In the human, as in the rat and cyclostomes, the glycemic effect of epinephrine occurs only during stress and/or unphysiological conditions, while the chronotropic effects are probably physiological from cyclostomes to man.
Epple
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Department of Anatomy, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Bertoni
J M
JM
Hathaway
C B
CB
D000328:Adult; D002395:Catecholamines / Q000097:blood*; D004562:Electrocardiography; D004837:Epinephrine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D008297:Male
D002395:Catecholamines; D004837:Epinephrine