title: [Hyperkeratosis lenticularis perstans (Flegel)].
abstract: The case of a female patient, 67 years old, with hyperkeratotic papules in the lower extremities which are characteristic of hyperkeratosis lenticularis perstans is reported. The clinical, histological and ultrastructural findings are shown. We have recorded the absence of Odland bodies in the area of the lesion, the persistence of desmosomes in the stratum corneum and lymphocytes with cerebriform nuclei within the inflammatory cell infiltrate. She was satisfactorily treated with etretinate and topical 5-fluorouracil We have reviewed the existing literature on this subject.
authors.affiliation: Hospital Universitario de Valladolid.
authors.forename: I
authors.initials: I
authors.lastname: Sánchez Jacob
authors.forename: A
authors.initials: A
authors.lastname: Miranda
authors.forename: N
authors.initials: N
authors.lastname: Pérez Oliva
authors.forename: P A
authors.initials: PA
authors.lastname: Quiñones
mesh_terms: D000368:Aged; D005260:Female; D005533:Foot Dermatoses / Q000473:pathology*; D006801:Humans; D007642:Keratosis / Q000473:pathology*; D007868:Leg Dermatoses / Q000473:pathology*; D012872:Skin Diseases, Vesiculobullous / Q000473:pathology*
vernacular_title: Hiperqueratosis lenticularis perstans (Flegel).