Rapid screening of experimental cardiac drugs using atria and a microcomputer.
The authors investigated the use of a programmable digitizer, multiplexer, and laboratory microcomputer as a rapid and accurate means of evaluating potential inotropic or antiarrhythmic drugs using mammalian atrial preparations.
Timonen
M K
MK
Department of Pharmacology, Orion Pharmaceutica, Espoo, Finland.
Sellin
L C
LC
Törnquist
K
K
Koskinen
L
L
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D016275:Atrial Function; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008838:Microcomputers; D009200:Myocardial Contraction / Q000187:drug effects*
D000889:Anti-Arrhythmia Agents; D002316:Cardiotonic Agents