[Effect of 11-deoxyprostaglandins E on the reproductive system].
The pharmacological properties of 4 derivatives of 11-desoxy-prostaglandins E (uterotonic, luteolytic, hypotensive, anti-inflammatory, diarrhogenic ones and also acute toxicity) were studied. Compound I possessed the uterotonic activity which decreased with an alpha-chain elongation and a radical introduction into a benzene ring. Compounds I and II exhibited the luteotropic properties at low doses and the luteolytic ones at high doses. The compounds under study had the hypotensive activity due to the presence of a benzene ring in a W-chain.
Murinova
M Iu
MIu
Bagaeva
S G
SG
Adler
M E
ME
Davydova
V A
VA
Lazareva
D N
DN
D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects; D003967:Diarrhea / Q000139:chemically induced; D004008:Diclofenac / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy; D005260:Female; D006168:Guinea Pigs; D007022:Hypotension / Q000139:chemically induced; D051379:Mice; D011374:Progesterone / Q000097:blood; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D014590:Uterine Contraction / Q000187:drug effects
D011459:Prostaglandins E, Synthetic; D004008:Diclofenac; D011374:Progesterone; D000527:Alprostadil; C034008:11-deoxyprostaglandin E1
Vliianie 11-dezoksi-prostaglandinov E na reproduktivnuiu sistemu.