[Sodium and lithium transport and steroid hormones of the adrenal glands].
Erythrocyte Na-Li countertransport was determined in 42 patients with essential hypertension (EH), 36 patients with hypertensive chronic diffuse glomerulonephritis, 47 patients with chronic pyelonephritis, 19 patients with renovascular hypertension and 9 patients with primary aldosteronism (PA). None of PA patients was treated with verospiron. Individual assessment of Na-Li exchange was made in 15 patients with nonspecific aorto-arteritis (NAA), untreated by steroid hormones, and in 2 glucocorticoid-treated NAA patients. Na-Li exchange parameters were compared before and after surgery in 7 patients with arterial hypertension (AH). Mean rate of Na-Li countertransport was nearly twice as high in EH patients as compared to the respective rate in patients with renal AH, whereas the difference in mean countertransport rates was not significant between EH and PA patients. Increased Na-Li exchange rate went down to normal values in a PA patient, while postoperative hydrocortizone treatment increased this rate in a patient with pheochromocytoma. In the remaining patients with symptomatic hypertensions (renovascular hypertension, pyelonephritic granular kidney, aortic coarctation, pheochromocytoma), Na-Li exchange remained unchanged after surgery. The rate of Na-Li exchange was increased in prednisolone-treated NAA patients, as compared to NAA patients receiving no glucocorticoids. The level of Na-Li exchange was stable over 9-18 months in AH patients with normal plasma aldosterone levels. No effects of obsidan, corinfar, clophelin, furosemide, hypothiazide and triampur on Na-Li exchange were identified.
Eliseev
A O
AO
Petrov
V V
VV
Chikhladze
N M
NM
Domba
G Iu
GIu
Kaĭkov
M I
MI
D000328:Adult; D001692:Biological Transport / Q000187:drug effects; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008094:Lithium / Q000097:blood*; D008297:Male; D012964:Sodium / Q000097:blood*; D013268:Stimulation, Chemical
D008094:Lithium; D012964:Sodium; D006854:Hydrocortisone
Transport natriia i litiia i steroidnye gormony nadpochechnikov.