Effect of indomethacin and prednisolone on the disruption of the blood-aqueous barrier after hyperthermia on the rabbit eye by focused ultrasound.
In 24 rabbits both eyes were treated in the perilimbic area with hyperthermia by focussed ultrasound at a frequency of 4.65 MHz. The intra-ocular pressure (IOP) decreased significantly in all eyes. The effect of pre-treatment with indomethacin and prednisolone on the inflammatory response induced by the insonification was assessed by determination of protein in the aqueous humour 2 h after ultrasound treatment. Local pre-treatment with indomethacin but not with prednisolone was followed by less increase in protein concentration of the aqueous humour as compared to placebo-treated controls. The IOP was not influenced significantly by the drug pre-treatments.
van Hees
C L
CL
Department of Ophthalmology, University Medical Centre, Leiden, The Netherlands.
van Delft
J L
JL
Sterk
C C
CC
van Haeringen
N J
NJ
Oosterhuis
J A
JA
D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects / Q000378:metabolism*; D001769:Blood / Q000378:metabolism*; D005123:Eye / Q000098:blood supply / Q000187:drug effects; D006979:Hyperthermia, Induced; D007213:Indomethacin / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects; D011239:Prednisolone / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D011817:Rabbits; D014465:Ultrasonics
D011506:Proteins; D011239:Prednisolone; D007213:Indomethacin