title: Thyroidectomy for Graves' disease: is hypothyroidism inevitable?
abstract: The outcome of 234 patients with Graves' disease treated by subtotal thyroidectomy over a 12-year period is analysed with specific reference to hypothyroidism. Of definite hypothyroid cases, 98% occurred within 2 years. Failure to develop hypothyroidism was statistically related to large remnant size and a large goitre preoperatively. Histological review showed that any degree of lymphocytic infiltration was associated with the development of hypothyroidism (50% vs 22%). Late onset hypothyroidism occurred rarely and is not an inevitable outcome of thyroid surgery in our hands.
authors.affiliation: Royal Hallamshire Hospital, Sheffield.
authors.forename: M
authors.initials: M
authors.lastname: Davenport
authors.forename: C H
authors.initials: CH
authors.lastname: Talbot
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology*; D012307:Risk Factors; D013965:Thyroidectomy; D013997:Time Factors
chemical_list: D001323:Autoantibodies