Polymerases and UV mutagenesis in Escherichia coli.
Evidence for and against the involvement of the known nucleic acid polymerases in UV mutagenesis in Escherichia coli is reviewed. There is no evidence that rules out the participation of any of them when they are present but only one, the alpha subunit of DNA polymerase III holoenzyme (polC gene product) has been shown to be essential. It is argued that the PolC protein that functions in UV mutagenesis may not be immediately recognizable as one of the normal cellular polymerases or polymerase complexes.
Bridges
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BA
Medical Research Council Cell Mutation Unit, University of Sussex, Falmer, Brighton, England.
Bates
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H
Sharif
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F
D001426:Bacterial Proteins / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D004269:DNA, Bacterial / Q000235:genetics / Q000528:radiation effects*; D004259:DNA-Directed DNA Polymerase / Q000502:physiology*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics* / Q000528:radiation effects; D005798:Genes, Bacterial / Q000528:radiation effects; D009154:Mutation; D012318:RNA Polymerase I / Q000502:physiology; D014466:Ultraviolet Rays
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D012318:RNA Polymerase I; D004259:DNA-Directed DNA Polymerase