Neutrophil activation during hemodialysis.
Oxidative metabolism of PMNs of uremic patients is enhanced due to unknown serum (plasma) factors which are removed during hemodialysis. Respiratory burst activity is diminished in both PMA-stimulated and unstimulated states compared to healthy controls. Hemodialysis normalizes stimulated and decreases unstimulated hydrogen peroxide production. Several authors found that resting and stimulated chemiluminescence (CL) during hemodialysis correlates with complement activation, whereas other authors describe CL using dialyzer membranes with only mild anaphylatoxin formation. Alterations of PMN carbohydrate metabolism in uremic patients improves during HD with polysulfone. HD with PMMA, however, activates glycogenolysis. These alterations may be responsible for disturbance in phagocytosis. Degranulation during HD also occurs in absence of complement activation. Calcium channel blockers decrease activation of PMNs using dialyzers with only little anaphylatoxin formation.
Haag-Weber
M
M
Department of Medicine, University of Freiburg, FRG.
Schollmeyer
P
P
Hörl
W H
WH
D050260:Carbohydrate Metabolism; D006801:Humans; D008213:Lymphocyte Activation; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology*; D010587:Phagocytosis; D010762:Phosphorylase a / Q000378:metabolism; D006435:Renal Dialysis; D014511:Uremia / Q000503:physiopathology
D010762:Phosphorylase a