Obstructive ureteropathy following radiation therapy for carcinoma of the cervix.
Between January 1959 and December 1986, 10 of 328 patients (3%) treated with curative intent using primary radiation therapy for carcinoma of the cervix developed obstructive ureteropathy due to fibrosis. The mean age of the patients with obstructive ureteropathy was 45 years and the median time to obstruction was 26 months. The obstruction was unilateral in 8 cases and involved the parametrial portion of the ureter in at least 5 cases. No predisposing risk factor was found to be associated with the development of obstructive ureteropathy. After corrective surgery, renal function remained normal in 8 patients, and resolution of the hydronephrosis occurred in 4 patients.
Parliament
M
M
Department of Radiation Oncology, Ontario Cancer Foundation, Ottawa General Hospital Division, Canada.
Genest
P
P
Girard
A
A
Gerig
L
L
Prefontaine
M
M
D000230:Adenocarcinoma / Q000532:radiotherapy; D000328:Adult; D001918:Brachytherapy / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000209:etiology; D008875:Middle Aged; D009367:Neoplasm Staging; D011867:Radioisotope Teletherapy / Q000009:adverse effects; D011878:Radiotherapy / Q000009:adverse effects*; D012307:Risk Factors; D014517:Ureteral Obstruction / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*