Automated DNA sequencing and the analysis of the human genome.
The Human Genome Initiative is a complex, multifaceted, international effort to establish a massive data base of map and sequence information for humans and other organisms. The success of this initiative is dependent upon the development of new technologies for the analysis of genomes. In this paper, an overview of the Human Genome Initiative is presented, and the current status of efforts to automate large-scale DNA sequence analysis is reviewed.
Smith
L M
LM
Department of Chemistry, University of Wisconsin-Madison 53706.
D001331:Automation / Q000295:instrumentation; D001483:Base Sequence; D002874:Chromosome Mapping; D001330:Electronic Data Processing; D004591:Electrophoresis, Polyacrylamide Gel; D015894:Genome, Human; D016045:Human Genome Project; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008969:Molecular Sequence Data; D009710:Nucleotide Mapping / Q000295:instrumentation* / Q000379:methods