title: [Pharmacokinetic and clinical studies of cefodizime in the field of obstetrics and gynecology].
abstract: Cefodizime (THR-221, CDZM), a new antibiotic, was studied pharmacokinetically and clinically. The results obtained are summarized as follows: 1. Concentrations of CDZM in internal genital tissues were quite high after an intravenous infusion. 2. Clinical effects of the therapy with CDZM using intravenous infusion twice daily were evaluated in 1 patient with endometritis, 2 patients with pyometra, 1 patient with extragenital abscess and 1 patient with BARTHOLIN'S gland abscess. Clinical responses were good in all 5 patients. No side effects nor abnormal laboratory test values due to the drug were noted.
authors.affiliation: Department of Obstetrics and Gynecology, Nara Medical University.
authors.forename: H
authors.initials: H
authors.lastname: Iioka
authors.forename: I
authors.initials: I
authors.lastname: Moriyama
authors.forename: K
authors.initials: K
authors.lastname: Nabuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Katagami
authors.forename: H
authors.initials: H
authors.lastname: Hisanaga
authors.forename: Y
authors.initials: Y
authors.lastname: Tuji
authors.forename: M
authors.initials: M
authors.lastname: Ichijo
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy*; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004341:Drug Evaluation; D004361:Drug Tolerance; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy* / Q000378:metabolism; D005836:Genitalia, Female / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D014018:Tissue Distribution
chemical_list: D002439:Cefotaxime; C033356:cefodizime