Age-dependent expression of microtubule-associated protein 2 in the ventromedial nucleus of the hypothalamus.
A distinctive developmental pattern of microtubule-associated protein 2 (MAP2) was detected in the ventromedial hypothalamus of rats. A region of more intense MAP2 immunoreactivity in this nucleus was present at birth, became prominent in a ringed appearance by postnatal day 4 and disappeared in the third postnatal week. This period of selective MAP2 expression in particular subcortical regions may signify important functions of MAP2 in the stabilization of developing dendritic structure.
Crandall
J E
JE
Department of Developmental Neurobiology, E. K. Shriver Center, Waltham, MA 02254.
Tobet
S A
SA
Fischer
I
I
Fox
T O
TO
D000375:Aging / Q000378:metabolism*; D000818:Animals; D005786:Gene Expression Regulation; D007150:Immunohistochemistry; D008869:Microtubule-Associated Proteins / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014697:Ventromedial Hypothalamic Nucleus / Q000254:growth & development / Q000378:metabolism*
D008869:Microtubule-Associated Proteins