[Glycerinated myocardiocyte fibers in the rat myocardium as one of the models in a preclinical assessment of antianginal agents].
A number of cardiotropic preparations (verapamil, obsidan, pyroxan) were studied in glycerinated fibres (GF) in the experiments on rats during five twenty four hours after ligation of coronary artery. Their ability in different degree to preserve cardiomyocyte contractile fibers from the injury of ischemic processes is revealed. Positive influence of antianginal therapy was also confirmed in the experiments with coronary artery ligation on awake animals, and in experiments on the identification of actomyosin complex components.
Dzhanpoladian
E G
EG
Sambelian
V M
VM
Kaĭfadzhian
M A
MA
Tatinian
N G
NG
Khoetsian
E L
EL
D000787:Angina Pectoris / Q000188:drug therapy* / Q000209:etiology; D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy / Q000209:etiology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005990:Glycerol / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000166:cytology*; D051381:Rats
D002317:Cardiovascular Agents; D005990:Glycerol
Glitserinizirovannye volokna kardiomiotsitov miokarda krys kak odna iz modeleĭ pri doklinicheskoĭ otsenke antianginal'nykh sredstv.