Serum pancreatic polypeptide and glucagon immunoreactivity in fasting healthy and diabetic children.
Serum pancreatic polypeptide (hPP) concentrations ranged in normal children from 45 pg/ml to 525 pg/ml with mean value at 185 +/- 49 pg/ml. Both hPP and glucagon immunoreactivity (IRG) levels showed age-dependent decrease during childhood. In diabetic children plasma IRG concentrations were significantly increased in comparison with the healthy subjects while hPP concentrations were only slightly elevated. The age dependence of the hormones levels was completely effaced in diabetics. No significant serum hPP norm IRG values dependence on the duration of diabetes was found. IRG/hPP relations correlated with age in healthy children despite those in diabetic ones.
Walczak
M
M
Mrozikiewicz
D
D
Dmochowski
K
K
Rewers
M
M
Cichy
W
W
D000293:Adolescent; D000375:Aging / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D005215:Fasting; D005934:Glucagon / Q000097:blood*; D006801:Humans; D007223:Infant; D007328:Insulin / Q000627:therapeutic use; D010191:Pancreatic Polypeptide / Q000097:blood*; D011863:Radioimmunoassay
D007328:Insulin; D010191:Pancreatic Polypeptide; D005934:Glucagon