Dual porphyria in double heterozygotes with porphobilinogen deaminase and uroporphyrinogen decarboxylase deficiencies.
A coexistent dual deficiency of porphobilinogen deaminase (PBG-D; EC 4.3.1.8) and uroporphyrinogen decarboxylase (EC 4.1.1.37) in erythrocytes was recognized in five individuals, four males and one female. Clinically, the female and one male were diagnosed as suffering from acute intermittent porphyria (AIP), and the other two males were diagnosed as having porphyria cutanea tarda (PCT). Biochemically, the excretion pattern of urinary and fecal heme precursors exhibited a complex constellation with signs characteristic for both AIP and PCT. A coexistent dual enzyme deficiency of PBG-D and URO-D could be confirmed by repeated studies over 10 years. Clinical courses of both disease manifestations were observed. Family investigations have shown that the two disorders do not consistently segregate together. The findings suggest that the dual porphyria reflects a double heterozygous condition of coexistent AIP and PCT genes in the same individual.
Doss
M O
MO
Department of Clinical Biochemistry, Faculty of Medicine, Philipp University, Marburg, Federal Republic of Germany.
D000368:Aged; D000642:Ammonia-Lyases / Q000172:deficiency*; D002262:Carboxy-Lyases / Q000172:deficiency*; D005260:Female; D006579:Heterozygote; D006801:Humans; D011163:Hydroxymethylbilane Synthase / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D017118:Porphyria, Acute Intermittent; D011164:Porphyrias / Q000201:enzymology / Q000235:genetics*; D012871:Skin Diseases / Q000201:enzymology / Q000235:genetics*; D014575:Uroporphyrinogen Decarboxylase / Q000172:deficiency* / Q000235:genetics
D011163:Hydroxymethylbilane Synthase; D002262:Carboxy-Lyases; D014575:Uroporphyrinogen Decarboxylase; D000642:Ammonia-Lyases