Ontogeny of cholecystokinin gene expression in the rat thalamus--a hybridization histochemical study.
We examined the ontogeny of cholecystokinin (CCK) gene expression in the rat thalamus using hybridization histochemistry. Maturation of CCK gene expression occurred over the course of a month, beginning in the medial geniculate nucleus on the 17th day of gestation. CCK mRNA was found in the caudal nuclei first, later in the rostral; the ventral were followed by the dorsal; and the lateral by the medial. In some nuclei, such as the medial geniculate, CCK mRNA was present prior to the full differentiation of the neurons; whereas in others, such as the mediodorsal, the neurons differentiated to almost adult morphology before CCK mRNA was detected.
Burgunder
J M
JM
Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892.
Young
W S
WS
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002766:Cholecystokinin / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D005314:Embryonic and Fetal Development; D005786:Gene Expression Regulation; D006651:Histocytochemistry; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013788:Thalamus / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*
D012333:RNA, Messenger; D002766:Cholecystokinin