title: [Fatal synergism of viral-bacterial infections (a model of influenza-streptococcal infections)].
abstract: A model of virus-bacterial infection involving A (PR-8/34) influenza virus and group B streptococcus is proposed to demonstrate the cyclic manifestations of fatal synergism of the causative agents correlating with either the cyclic detection of influenza virus antigens in the infection focus on administration of avirulent streptococcal Fos4 strain, or with the time-course of activity shown by natural killers on administration of virulent streptococcal Fos8 strain. Based on the presented data on the cyclic character of fatalities, whose dynamics varies only slightly with the biological properties of the second agent, a conclusion has been derived on (1) the simultaneous influence of various factors in the formation of the mechanisms of infection transformation, (2) the capability of the cell receptor apparatus to respond to an external stimulus which is the most important of these mechanisms, and (3) the effects of the biological properties of the causative agents on the fatal effect manifestations.
authors.forename: T Ia
authors.initials: TIa
authors.lastname: Dubrovina
authors.forename: K B
authors.initials: KB
authors.lastname: Grabovskaia
authors.forename: I A
authors.initials: IA
authors.lastname: Ivanova
authors.forename: N K
authors.initials: NK
authors.lastname: Shidlovskaia
authors.forename: R Ia
authors.initials: RIa
authors.lastname: Poliak
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D009980:Influenza A virus / Q000472:pathogenicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000150:complications / Q000401:mortality*; D013290:Streptococcal Infections / Q000150:complications / Q000401:mortality*; D013292:Streptococcus agalactiae / Q000472:pathogenicity*; D014774:Virulence
vernacular_title: Leta'lnyĭ sinergizm virus-bakteria'lnykh infektsiĭ (mode'l: gripp-streptokokk).