Brain tumor imaging with synthesized 18F-fluorophenylalanine and positron emission tomography.
Two patients with cerebral gliomas were studied with 18F-fluorophenylalanine, newly synthesized by the electrophilic substitution reaction, using positron emission tomography. The tracer accumulated markedly in the tumor lesion and delineated the extent of the lesion. This new tracer will be promising in the diagnosis of gliomas.
Mineura
K
K
Neurosurgical Service, Akita University Hospital, Japan.
Kowada
M
M
Shishido
F
F
D001254:Astrocytoma / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D005462:Fluorine Radioisotopes; D005910:Glioma / Q000000981:diagnostic imaging*; D006801:Humans; D008875:Middle Aged; D010649:Phenylalanine / Q000031:analogs & derivatives*; D014055:Tomography, Emission-Computed; D010135:p-Fluorophenylalanine
D005462:Fluorine Radioisotopes; D010649:Phenylalanine; D010135:p-Fluorophenylalanine