title: Effects of food intake and body weight on a serotonergic turnover index in rat hypothalamus.
abstract: Absolute levels and ratio of serotonergic compounds in food-related hypothalamic nuclei were determined with a chromatographic method comparing for control (C) versus lean (L) versus obese (O) rats. In all three groups, a second parameter, i.e., fasting (F) versus satiation (S) was superimposed on the body weight factor. Indoleamine levels failed to show statistical differences depending on the body weight and/or the nutritional status. A significant negative correlation between an index of the serotonin turnover, the 5-HIAA/5-HT ratio, and body weight was found for the paraventricular (PVN) nucleus in the C and L groups as well as for the lateral (LH) nucleus for the C and O groups. A positive correlation was found for the ventromedian (VMH) nucleus in the O group. These data suggest that the body weight factor is implicated in the central serotonergic regulation more than the feeding parameter.
authors.affiliation: Laboratoire de Pharmacologie, UA CNRS 594, Faculté de Pharmacie, Chatenay-Malabry, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Gardier
authors.forename: J H
authors.initials: JH
authors.lastname: Trouvin
authors.forename: M
authors.initials: M
authors.lastname: Orosco
authors.forename: S
authors.initials: S
authors.lastname: Nicolaidis
authors.forename: C
authors.initials: C
authors.lastname: Jacquot
mesh_terms: D000818:Animals; D001835:Body Weight; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D007031:Hypothalamus / Q000378:metabolism* / Q000502:physiology / Q000503:physiopathology; D009765:Obesity / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*
chemical_list: D012701:Serotonin