[Equation of the dose-time-effect relations in cases of a single intake of xenobiotics].
Proceeding from chemical and biologic kinetic characteristics an equation for dose/time/effect dependence was derived for the considered case. Effect dependence on the dose (as a difference logarythm of maximum and instantaneous effects) was described by a line and on time by a curve exponentially striving for limit. A dose/effect equation was given for the period of 2 weeks, thus the constant speed of interaction of xenobiotics and receptors was identified in a critical organ.
Pavlov
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D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006838:Hydrocarbons / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D008433:Mathematics; D008954:Models, Biological; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
D006838:Hydrocarbons
Uravnenie zavisimosti doza-vremia-éffekt dlia sluchaia odnokratnogo postupleniia ksenobiotika v organizm.