What's new in the localization of sex steroids in the human ovary and its tumors?
It is important to understand the distribution of steroidogenesis in steroid producing tissues in order to obtain a better understanding of steroid metabolism. Recent advances in purification and subsequent generation of antibodies against cytochromes P-450 specific for steroid hormone biosynthesis have made it possible to localize the sites of steroidogenesis immunohistochemically. This review provides the localization of sex-steroid hormone biosynthesis in normal and pathological human ovaries including sex-cord stromal tumors, hyperthecosis and Brenner tumor, as determined by the tissue distribution of immunoreactivity of individual enzymes specific for different stages of the biosynthetic process.
Sasano
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H
Department of Pathology, Tohoku University School of Medicine, Sendai, Japan.
Sasano
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D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D010053:Ovary / Q000166:cytology / Q000378:metabolism*; D013256:Steroids / Q000378:metabolism*
D013256:Steroids