title: Drinking saccharin increases food intake and preference--I. Comparison with other drinks.
abstract: To examine the orosensory and postingestive effects of saccharin solution on food intake and food preference, freely feeding rats were given flavored food to eat and a solution to drink for 2 h on eight to ten occasions. Relative to trials with a different flavored food and only water to drink, food intake was increased by drinking 0.2% saccharin or 0.45% NaCl, unaffected by drinking 1% almond extract, and decreased by drinking 10% glucose. Food preference, which was assessed in a choice test with simultaneous access to the two flavored foods, was increased by drinking 0.2% saccharin or 10% glucose and unaffected by drinking 1% almond extract or 0.45% NaCl. These results are consistent with the possibility that a combination of the oral and hydrational properties of saccharin solution increase food intake. Saccharin's sweet taste may be responsible for its effects on food preference.
authors.affiliation: Monell Chemical Senses Center, Philadelphia, PA 19104.
authors.forename: M G
authors.initials: MG
authors.lastname: Tordoff
authors.forename: M I
authors.initials: MI
authors.lastname: Friedman
mesh_terms: D000818:Animals; D004435:Eating; D005421:Flavoring Agents; D005518:Food Preferences; D005947:Glucose / Q000008:administration & dosage; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012439:Saccharin / Q000008:administration & dosage*; D012996:Solutions
chemical_list: D005421:Flavoring Agents; D012996:Solutions; D012439:Saccharin; D005947:Glucose