title: Sarcoidosis: correlation of pulmonary parenchymal pattern at CT with results of pulmonary function tests.
abstract: The appearances of the lungs on radiographs and computed tomographic (CT) scans were correlated with degree of uptake on gallium scans and results of pulmonary function tests (PFTs) in 27 patients with sarcoidosis. CT scans were evaluated both qualitatively and quantitatively. Patients were divided into five categories on the basis of the pattern of abnormality at CT: 1 = normal (n = 4); 2 = segmental air-space disease (n = 4); 3 = spherical (alveolar) masslike opacities (n = 4); 4 = multiple, discrete, small nodules (n = 6); and 5 = distortion of parenchymal structures (fibrotic end-stage sarcoidosis) (n = 9). The percentage of the volume judged to be abnormal (CT grade) was correlated with PFT results for each CT and radiographic category. CT grades were also correlated with gallium scanning results and percentage of lymphocytes recovered from bronchoalveolar lavage (BAL). Patients in CT categories 1 and 2 had normal lung function, those in category 3 had mild functional impairment, and those in categories 4 and 5 showed moderate to severe dysfunction. The overall CT grade correlated well with PFT results expressed as a percentage of the predicted value. In five patients, CT scans showed extensive parenchymal disease not seen on radiographs. CT grades did not correlate with the results of gallium scanning or BAL lymphocytes. The authors conclude that patterns of parenchymal sarcoidosis seen at CT correlate with the PFT results and can be used to indicate respiratory impairment.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, NC.
authors.forename: C J
authors.initials: CJ
authors.lastname: Bergin
authors.forename: D Y
authors.initials: DY
authors.lastname: Bell
authors.forename: C L
authors.initials: CL
authors.lastname: Coblentz
authors.forename: C
authors.initials: C
authors.lastname: Chiles
authors.forename: G
authors.initials: G
authors.lastname: Gamsu
authors.forename: N R
authors.initials: NR
authors.lastname: MacIntyre
authors.forename: R E
authors.initials: RE
authors.lastname: Coleman
authors.forename: C E
authors.initials: CE
authors.lastname: Putman
mesh_terms: D000402:Airway Obstruction / Q000503:physiopathology; D005260:Female; D005355:Fibrosis / Q000000981:diagnostic imaging; D005541:Forced Expiratory Volume; D005710:Gallium Radioisotopes; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D010994:Pleura / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012129:Respiratory Function Tests; D012507:Sarcoidosis / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed
chemical_list: D005710:Gallium Radioisotopes