title: Metabolism of androstenedione by placental microsomes in pregnancy hypertension.
abstract: The metabolism of [19-3H3]androstenedione by human placental microsomes was studied in vitro by radiometric analysis which distinguishes between 19-hydroxylation and elimination of the C-19 carbon. The ratio of the metabolic products tritiated water/tritiated formic acid is significantly greater for microsomes from patients with pregnancy hypertension when compared with normotensive pregnant women. This indicates that aromatization (2-hydroxylation) is deficient in pregnancy hypertension.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Western Australia.
authors.forename: M E
authors.initials: ME
authors.lastname: Hähnel
authors.forename: J D
authors.initials: JD
authors.lastname: Martin
authors.forename: C A
authors.initials: CA
authors.lastname: Michael
authors.forename: R
authors.initials: R
authors.lastname: Hähnel
mesh_terms: D000735:Androstenedione / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism*; D010084:Oxidation-Reduction; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000378:metabolism*
chemical_list: D000735:Androstenedione