title: MRI of "diffusion" in the human brain: new results using a modified CE-FAST sequence.
abstract: "Diffusion-weighted"MRI in the normal human brain and in a patient with a cerebral metastasis is demonstrated. The method employed was a modified CE-FAST sequence with imaging times of only 6-10 s using a conventional 1.5-T whole-body MRI system (Siemens Magnetom). As with previous phantom and animal studies, the use of strong gradients together with macroscopic motions in vivo causes unavoidable artifacts in diffusion-weighted images of the human brain. While these artifacts are shown to be considerably reduced by averaging of 8-16 images, the resulting diffusion contrast is compromised by unknown signal losses due to motion.
authors.affiliation: Max-Planck-Institut für biophysikalische Chemie, Göttingen, Federal Republic of Germany.
authors.forename: K D
authors.initials: KD
authors.lastname: Merboldt
authors.forename: H
authors.initials: H
authors.lastname: Bruhn
authors.forename: J
authors.initials: J
authors.lastname: Frahm
authors.forename: M L
authors.initials: ML
authors.lastname: Gyngell
authors.forename: W
authors.initials: W
authors.lastname: Hänicke
authors.forename: M
authors.initials: M
authors.lastname: Deimling
mesh_terms: D000368:Aged; D001921:Brain / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism; D004058:Diffusion; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*