title: [Intracerebroventricular morphine therapy. Apropos of 79 patients].
abstract: The authors report their experience in the treatment of 79 patients suffering from intractable cancer pain with intra-cerebro-ventricular morphine. They obtain a long-lasting analgesia (34.2 hours at the beginning of treatment and 27.9 hours at the end; mean follow-up of 65 days) with a very low daily morphine consumption. The results obtained, good and very good in 95% of the cases, could be explained by patients' selection criteria and quality of the follow-up (prospective sheet given to the patients, regular phone calls and consultations in the pain clinic). The authors discuss the indications of this technique in relation with other neurosurgical procedures, taking into account the neurophysiological mechanism of action of morphine.
authors.affiliation: Service de Neurochirurgie A, Hôpital B, C.H.R., Lille.
authors.forename: S
authors.initials: S
authors.lastname: Blond
authors.forename: J
authors.initials: J
authors.lastname: Meynadier
authors.forename: T
authors.initials: T
authors.lastname: Dupard
authors.forename: R
authors.initials: R
authors.lastname: Assaker
authors.forename: C
authors.initials: C
authors.lastname: Brichard
authors.forename: J L
authors.initials: JL
authors.lastname: Christiaens
authors.forename: A
authors.initials: A
authors.lastname: Demaille
mesh_terms: D005260:Female; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D009369:Neoplasms; D010148:Intractable Pain / Q000188:drug therapy*
chemical_list: D009020:Morphine
vernacular_title: La morphinothérapie intracérébro-ventriculaire. A propos de 79 patients.