Interspecific variations of cerebral endothelial cholinesterases in rodents and carnivores.
The cholinesterase equipment of cerebral microvessels was studied in some rodents and carnivores using the Koelle-Friedenwald histochemical method with 3 artificial substrates and specific inhibitors for butyrylcholinesterase or acetylcholinesterase. Our observations reveal a great heterogeneity in cholinesterase types and their distribution in each of the different species studied. Only in the rat, butyrylcholinesterase appears to be a marker for the microvessels provided with a blood-brain barrier.
Trancard
J
J
Centre de Recherche Delalande, Rueil-Malmaison, France.
Delamanche
I S
IS
Ruiz
G
G
Bouchaud
C
C
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000098:blood supply / Q000201:enzymology*; D002091:Butyrylcholinesterase / Q000032:analysis; D002092:Butyrylthiocholine / Q000378:metabolism; D002335:Carnivora / Q000378:metabolism*; D002802:Cholinesterases / Q000032:analysis* / Q000145:classification; D004727:Endothelium / Q000201:enzymology*; D006651:Histocytochemistry; D012377:Rodentia / Q000378:metabolism*; D013045:Species Specificity; D013860:Thiocholine / Q000031:analogs & derivatives / Q000378:metabolism
C009063:propionylthiocholine; D002092:Butyrylthiocholine; D013860:Thiocholine; D002091:Butyrylcholinesterase; D002802:Cholinesterases; D000109:Acetylcholine