title: Pharmacokinetics of felodipine in patients with impaired renal function.
abstract: 1. The pharmacokinetics of felodipine and its effects on blood pressure and heart rate were studied in eight male patients aged between 28 and 57 years with a glomerular filtration rate, GFR, between 8 and 68 ml min-1, following single i.v. and oral administration. 2. Clearance, Cmax, AUC, Vss and V, of felodipine were unaffected by the renal disease. The metabolite excretion (14C-labelled) was slower than in healthy subjects. Initial renal clearance of these metabolites correlated with individual GFR values. The total amount of the dose excreted in the urine was also decreased.
authors.affiliation: Department of Clinical Pharmacology, University of Göteborg, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Edgar
authors.forename: C G
authors.initials: CG
authors.lastname: Regårdh
authors.forename: P O
authors.initials: PO
authors.lastname: Attman
authors.forename: M
authors.initials: M
authors.lastname: Aurell
authors.forename: H
authors.initials: H
authors.lastname: Herlitz
authors.forename: G
authors.initials: G
authors.lastname: Johnsson
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics* / Q000494:pharmacology; D015736:Felodipine; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006977:Hypertension, Renal / Q000378:metabolism*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D002121:Calcium Channel Blockers; D009568:Nitrendipine; D015736:Felodipine