title: Ticarcillin/clavulanic acid versus clindamycin and gentamicin in the treatment of post-cesarean endometritis following antibiotic prophylaxis.
abstract: One hundred fifty-two women who received cefazolin prophylaxis and subsequently developed postpartum endometritis were randomized to treatment with either ticarcillin/clavulanic acid (75) or clindamycin-gentamicin (77). Bacteria isolated from the endometrium were predominantly facultative anaerobic bacteria. The ratio of facultative anaerobes to obligate anaerobes was 3:1. Nineteen percent of the women were bacteremic, with mycoplasma the organism most frequently isolated from venous blood specimens. Cure rates were similar for both groups: ticarcillin/clavulanic acid 85% and clindamycin-gentamicin 81%. The advantages of ticarcillin/clavulanic acid are an increased spectrum of activity against beta-lactamase-producing bacteria, less toxicity, and lower cost.
authors.affiliation: Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
authors.forename: S
authors.initials: S
authors.lastname: Faro
authors.forename: M
authors.initials: M
authors.lastname: Martens
authors.forename: H
authors.initials: H
authors.lastname: Hammill
authors.forename: L E
authors.initials: LE
authors.lastname: Phillips
authors.forename: D
authors.initials: D
authors.lastname: Smith
authors.forename: G
authors.initials: G
authors.lastname: Riddle
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002585:Cesarean Section / Q000009:adverse effects; D002969:Clavulanic Acids / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004716:Endometritis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D011247:Pregnancy; D011645:Puerperal Infection / Q000188:drug therapy*; D011897:Random Allocation; D013982:Ticarcillin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D005839:Gentamicins; D002981:Clindamycin; D013982:Ticarcillin