Cod liver oil inhibits neutrophil and monocyte chemotaxis in healthy males.
Epidemiological evidence suggests a reduced rate of chronic inflammatory diseases and ischaemic heart disease in populations with a high consumption of fish. This has been ascribed to the high content in sea food of polyunsaturated fatty acids (PUFAs), belonging to the n - 3 family. We have studied neutrophil and monocyte chemotaxis in 12 healthy males before and after 6 weeks supplementation with cod liver oil, corresponding to 5.3 g n - 3 PUFAs daily. Neutrophil and monocyte chemotaxis were investigated using the under agarose technique with N-formyl-methionyl-leucyl-phenylalanine (N-FMLP) and autologous serum as chemoattractants. Neutrophil chemotaxis towards both chemoattractants and monocyte chemotaxis towards N-FMLP were significantly reduced after supplementation with cod liver oil.
Schmidt
E B
EB
Department of Clinical Chemistry, Aalborg Hospital, Denmark.
Pedersen
J O
JO
Ekelund
S
S
Grunnet
N
N
Jersild
C
C
Dyerberg
J
J
D000328:Adult; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003060:Cod Liver Oil / Q000494:pharmacology*; D005395:Fish Oils / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009504:Neutrophils / Q000187:drug effects
D005395:Fish Oils; D009240:N-Formylmethionine Leucyl-Phenylalanine; D003060:Cod Liver Oil