title: Hyperfunctioning and nonhyperfunctioning benign adrenal cortical lesions: characterization and comparison with MR imaging.
abstract: The authors evaluated the potential of magnetic resonance (MR) imaging at 0.35 T to permit differentiation of nine hyperfunctioning adrenal cortical lesions from 21 nonhyperfunctioning adrenal cortical adenomas. Both qualitative data (visual assessment) and quantitative data (signal intensity ratios, T1, and T2) were used for tissue characterization. With a 2,000/56-100 sequence (repetition time msec/echo time msec), the majority of lesions were visually isointense to liver. Of 34 quantitative measures, only lesion-liver and lesion-kidney intensity ratios at 2,000/150 showed statistically significant differences among nonhyperfunctioning adenomas, aldosterone-producing lesions, and corticosteroid-producing lesions; however, the authors question the significance of these differences because of the abundant noise associated with the 2,000/150 sequence. The results suggest that nonhyperfunctioning adrenal cortical adenomas cannot be distinguished from benign hyperfunctioning cortical lesions with use of MR imaging at 0.35 T.
authors.affiliation: Department of Radiology, University of Michigan Medical Center, Ann Arbor 48109.
authors.forename: E M
authors.initials: EM
authors.lastname: Remer
authors.forename: R M
authors.initials: RM
authors.lastname: Weinfeld
authors.forename: G M
authors.initials: GM
authors.lastname: Glazer
authors.forename: L E
authors.initials: LE
authors.lastname: Quint
authors.forename: I R
authors.initials: IR
authors.lastname: Francis
authors.forename: M D
authors.initials: MD
authors.lastname: Gross
authors.forename: F L
authors.initials: FL
authors.lastname: Bookstein
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism; D000302:Adrenal Cortex / Q000473:pathology; D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D000308:Adrenocortical Hyperfunction / Q000175:diagnosis* / Q000378:metabolism; D000328:Adult; D000450:Aldosterone / Q000096:biosynthesis; D003937:Diagnosis, Differential; D006801:Humans; D006854:Hydrocortisone / Q000096:biosynthesis; D006965:Hyperplasia / Q000175:diagnosis / Q000378:metabolism; D008279:Magnetic Resonance Imaging
chemical_list: D000450:Aldosterone; D006854:Hydrocortisone