title: In vitro comparison of velocity profiles and turbulent shear distal to polyurethane trileaflet and pericardial prosthetic valves.
abstract: A comparative study of flow dynamics past biomer trileaflet valves and a pericardial bioprosthetic valve under steady and physiological pulsatile flow conditions in vitro is reported in this paper. The velocity profiles and the turbulent shear stresses distal to the valves were measured using laser Doppler anemometry. The authors' results showed that the velocity profiles distal to the trileaflet valves were similar to that measured distal to the pericardial valve. Higher magnitudes of absolute turbulent shear stresses were measured distal to the synthetic valves in comparison to the pericardial valves. However, when the stresses were nondimensionalized with respect to the orifice diameter at the inlet aspect, the stresses were comparable for all of the three valves. With design modifications to increase the orifice diameter at the inlet aspect of the polyurethane valves, the turbulent stresses distal to the valves can be minimized. Such in vitro studies on the flow dynamics past the polyurethane valves can provide information towards design changes to improve the performance characteristics of these valves. Polyurethane valves with flow characteristics comparable to the pericardial valves can be manufactured relatively inexpensively compared to mechanical or tissue valve prosthesis. Hence, the synthetic valves may be a viable alternative for short-term use in total artificial heart devices as a bridge to transplant.
authors.affiliation: Department of Biomedical Engineering, University of Iowa, Iowa City 52242.
authors.forename: K B
authors.initials: KB
authors.lastname: Chandran
authors.forename: R
authors.initials: R
authors.lastname: Fatemi
authors.forename: R
authors.initials: R
authors.lastname: Schoephoerster
authors.forename: D
authors.initials: D
authors.lastname: Wurzel
authors.forename: G
authors.initials: G
authors.lastname: Hansen
authors.forename: G
authors.initials: G
authors.lastname: Pantalos
authors.forename: L S
authors.initials: LS
authors.lastname: Yu
authors.forename: W J
authors.initials: WJ
authors.lastname: Kolff
mesh_terms: D001705:Bioprosthesis; D001783:Blood Flow Velocity; D006350:Heart Valve Prosthesis; D006801:Humans; D066298:In Vitro Techniques; D010496:Pericardium; D011140:Polyurethanes; D011474:Prosthesis Design; D011673:Pulsatile Flow
chemical_list: D011140:Polyurethanes