title: Extension of multiple drug resistant Plasmodium falciparum malaria in Africa: report of a Central African case.
abstract: A 24-year-old Caucasian male, living in the Central African Republic, presented with fever due to Plasmodium falciparum infection, although he steadily took chloroquine and sulfadoxine-pyrimethamine chemoprophylaxis. Despite treatment with the same drugs at high doses, the parasitaemia persisted. Clinical and parasitological recovery was obtained by the use of quinine. Chloroquine-resistant Plasmodium falciparum strains have spread in all tropical areas. Multiple drug resistance, already described in Asia, has also begun to appear in Africa.
authors.affiliation: Institut Pasteur de Bangui, Bangui, Central African Republic.
authors.forename: L
authors.initials: L
authors.lastname: Belec
authors.forename: P
authors.initials: P
authors.lastname: Bouree
authors.forename: J
authors.initials: J
authors.lastname: Testa
authors.forename: J
authors.initials: J
authors.lastname: Delmont
authors.forename: B
authors.initials: B
authors.lastname: Quenum
authors.forename: A J
authors.initials: AJ
authors.lastname: Georges
mesh_terms: D000328:Adult; D000818:Animals; D002738:Chloroquine / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D010963:Plasmodium falciparum; D011739:Pyrimethamine / Q000627:therapeutic use*; D011803:Quinine / Q000627:therapeutic use*; D013413:Sulfadoxine / Q000627:therapeutic use*; D013424:Sulfanilamides / Q000627:therapeutic use*
chemical_list: D013424:Sulfanilamides; D013413:Sulfadoxine; D002738:Chloroquine; D011803:Quinine; D011739:Pyrimethamine