title: Synthesis and biological activity of a series of piperazine-2,3-dione containing penicillins and 6 alpha-formamidopenicillins. I. Derivatives substituted at C(5) or C(6) of the piperazine ring.
abstract: The synthesis and antibacterial activity of a series of penicillins and 6 alpha-formamidopenicillins containing a C(5) or C(6)-substituted piperazine-2,3-dione moiety in the C(6)-beta-sidechain is described.
authors.affiliation: Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Surrey, U.K.
authors.forename: D T
authors.initials: DT
authors.lastname: Davies
authors.forename: F P
authors.initials: FP
authors.lastname: Harrington
authors.forename: S J
authors.initials: SJ
authors.lastname: Knott
authors.forename: R
authors.initials: R
authors.lastname: Southgate
mesh_terms: D010406:Penicillins / Q000138:chemical synthesis* / Q000494:pharmacology; D010879:Piperazines / Q000138:chemical synthesis; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D010406:Penicillins; D010879:Piperazines