Transcutaneous absorption of naproxen gel.
The kinetics of naproxen was studied in healthy volunteers after cutaneous application of gels containing 5 and 10% of the drug. Bioavailability was estimated from serum concentration and cumulative urinary metabolite excretion data, both determined up to 96 hours after drug administration. The mean bioavailability after the 10% gel was 1.1% (serum data) and 1.0% (urine data), and after the 5% gel it was 2.1% (serum data) and 1.8% (urine data). Despite the small amount of naproxen absorbed, a potential pharmacological effect, due to cutaneous accumulation of the drug following topical administration, may be suggested from the course of the serum concentration-time curves.
van den Ouweland
F A
FA
Department of Medicine, University Hospital Sint Radboud, Nijmegen, The Netherlands.
Eenhoorn
P C
PC
Tan
Y
Y
Gribnau
F W
FW
D000279:Administration, Cutaneous; D000328:Adult; D001682:Biological Availability; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D009288:Naproxen / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D012869:Skin Absorption
D005782:Gels; D009288:Naproxen