title: A brain-specific transcription activator.
abstract: We have identified a DNA binding protein, named BETA, that interacts with the same (B) transcriptional regulatory sequence as the known transcription factor NF-kappa B. BETA is found only in gray matter throughout the brain, and not in a variety of other rat tissues. Two binding sites for BETA are present adjacent to the promoter of the rat proenkephalin gene. Transfection of primary brain cultures that express BETA, with a reporter gene driven by the SV40 promoter linked to BETA DNA binding sites, results in transcriptional activation. We infer that BETA is a brain-specific transcription activator.
authors.affiliation: Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Korner
authors.forename: A
authors.initials: A
authors.lastname: Rattner
authors.forename: F
authors.initials: F
authors.lastname: Mauxion
authors.forename: R
authors.initials: R
authors.lastname: Sen
authors.forename: Y
authors.initials: Y
authors.lastname: Citri
mesh_terms: D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004586:Electrophoresis; D004745:Enkephalins / Q000235:genetics; D016328:NF-kappa B; D009474:Neurons / Q000378:metabolism; D011401:Promoter Regions, Genetic; D011498:Protein Precursors / Q000235:genetics; D051381:Rats; D014018:Tissue Distribution; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D004745:Enkephalins; D016328:NF-kappa B; D011498:Protein Precursors; D014157:Transcription Factors; C029992:proenkephalin