Cardiovascular regulation and lipoprotein profile during administration of co-dergocrine in essential hypertension.
Co-dergocrine has recently been demonstrated acutely to lower plasma norepinephrine (NE) and blood pressure (BP) in patients with essential hypertension, and similar results have been obtained during chronic administration of co-dergocrine to healthy men. The present study investigated the effect of 3 weeks of treatment with co-dergocrine 4 mg/day on BP, plasma catecholamines, certain other BP-regulating factors and serum lipoproteins in patients with essential hypertension. Compared to placebo conditions, co-dergocrine decreased supine BP and heart rate by -7% and the upright plasma NE level by -24%. Supine plasma NE also fell (-24%). Total cholesterol and the LDL + VLDL-cholesterol lipoprotein fraction were lowered by -6%. No significant change was observed in plasma renin activity, angiotensin II, aldosterone and epinephrine levels, whole blood and plasma volume, exchangeable sodium, and the cardiovascular responsiveness to NE, angiotensin II and isoproterenol. The findings suggest that in patients with essential hypertension, chronic treatment with co-dergocrine may slightly decrease sympathetic outflow and, at least in the short-term, lower the potentially atherogenic serum LDL + VLDL - cholesterol fraction.
Uehlinger
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DE
Medizinische Poliklinik, University of Berne, Switzerland.
Weidmann
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P
Gnaedinger
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MP
D000328:Adult; D000368:Aged; D000804:Angiotensin II / Q000097:blood / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004088:Dihydroergotoxine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005919:Glomerular Filtration Rate; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D007262:Infusions, Intravenous; D007545:Isoproterenol / Q000494:pharmacology; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood / Q000494:pharmacology; D012079:Renal Circulation / Q000187:drug effects
D000959:Antihypertensive Agents; D008074:Lipoproteins; D004088:Dihydroergotoxine; D000804:Angiotensin II; D007545:Isoproterenol; D009638:Norepinephrine