title: Muscarinic pharmacology of the spinal cord of the neonatal rat in vitro.
abstract: The pharmacology of two muscarinic responses, recorded from the ventral roots of the spinal cord in the neonatal rat, have been compared: the depolarising response and the inhibition of the monosynaptic compound action potential (CAP). Pirenzepine was more potent than AF-DX 116 in antagonising the depolarising response. However, the potencies of these compounds indicated that this response may be mediated by neither M1 nor M2 (cardiac-like) receptors. The drug AF-DX 116 (1 microM), but not pirenzepine, selectively reduced the inhibitory effect. It is concluded that the receptors mediating these two responses are different.
authors.affiliation: Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, U.K.
authors.forename: N R
authors.initials: NR
authors.lastname: Newberry
authors.forename: G P
authors.initials: GP
authors.lastname: Connolly
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D001285:Atropine / Q000494:pharmacology; D066298:In Vitro Techniques; D009116:Muscarine / Q000494:pharmacology*; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*
chemical_list: D010890:Pirenzepine; D001285:Atropine; D009116:Muscarine; C048593:otenzepad