[Body adaptation to stress exposure enhances cardiac resistance to adrenotoxic damage].
Models of adrenergic arrhythmias were produced on isolated rat heart under the adrenalin concentration in the perfusion solution of 5.10(-5) M. The rhythm disturbances were accompanied by a pronounced depression of contractile function. It was shown that preliminary adaptation of animals to short-term stress exposures reduced the duration of arrhythmias more than sixfold the contractile function, being maintained at a higher level than in control. The adaptation cardioprotective effect was compared with the effects of adaptation and propranolol appeared similar.
Malyshev
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IIu
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine / Q000633:toxicity*; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D011433:Propranolol / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
D011433:Propranolol; D004837:Epinephrine
Adaptatsiia organizma k stressornym vozdeĭstviiam povyshaet rezistentnost' serdtsa k adrenotoksicheskomu povrezhdeniiu.