title: H DNA amplification in Leishmania resistant to both arsenite and methotrexate.
authors.affiliation: Department of Microbiology and Immunology, University of Health Sciences, Chicago Medical School, IL 60064.
authors.forename: K
authors.initials: K
authors.lastname: Katakura
authors.forename: K P
authors.initials: KP
authors.lastname: Chang
mesh_terms: D000818:Animals; D001151:Arsenic / Q000494:pharmacology*; D018053:Arsenites; D015139:Blotting, Southern; D015342:DNA Probes; D004270:DNA, Circular / Q000032:analysis; D004278:DNA, Superhelical / Q000032:analysis; D004351:Drug Resistance / Q000235:genetics; D004586:Electrophoresis / Q000379:methods; D005784:Gene Amplification; D014644:Genetic Variation; D007891:Leishmania / Q000187:drug effects / Q000235:genetics*; D008727:Methotrexate / Q000494:pharmacology*; D009097:Multienzyme Complexes / Q000235:genetics; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics; D013940:Thymidylate Synthase / Q000235:genetics
chemical_list: D018053:Arsenites; D015342:DNA Probes; D004270:DNA, Circular; D004278:DNA, Superhelical; D009097:Multienzyme Complexes; C056930:thymidylate synthase-dihydrofolate reductase; D013762:Tetrahydrofolate Dehydrogenase; D013940:Thymidylate Synthase; C015001:arsenite; D001151:Arsenic; D008727:Methotrexate