title: Cocaine and lidocaine as topical urethral anesthetics.
abstract: To evaluate the efficacy of topical cocaine combined with lidocaine as a urethral anesthetic, a double-blind, randomized, prospective study was performed comparing lidocaine combined with cocaine or placebo in male outpatient cystoscopy. Evaluations were based on a scale of 1 to 10, with 1 representing no discomfort and 10 extreme discomfort as judged by the patient, and 1 representing the best tolerance and 10 extreme intolerance as judged by the physician. Patients who received lidocaine plus cocaine reported a mean score of 3.33 for over-all discomfort of cystoscopy. This was not significantly different than for lidocaine alone. This finding indicates a lack of a summation effect in combining topical anesthetics. Patients undergoing repeat examinations were no more comfortable than those undergoing initial cystoscopy but older patients tolerated the procedure significantly better than younger patients.
authors.affiliation: Urology Service, Department of Surgery, Honolulu Army Medical Center, Tripler, Hawaii.
authors.forename: M J
authors.initials: MJ
authors.lastname: Pliskin
authors.forename: K J
authors.initials: KJ
authors.lastname: Kreder
authors.forename: P M
authors.initials: PM
authors.lastname: Desmond
authors.forename: M L
authors.initials: ML
authors.lastname: Dresner
mesh_terms: D000772:Anesthesia, Local; D000779:Anesthetics, Local; D003042:Cocaine; D003558:Cystoscopy; D004311:Double-Blind Method; D006801:Humans; D008012:Lidocaine; D008297:Male; D010147:Pain Measurement; D011897:Random Allocation; D014521:Urethra
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine; D003042:Cocaine