title: Development and optimisation of a high-performance liquid chromatographic assay for tioconazole and its potential impurities. Part II. Selection of detection conditions for potential impurities.
abstract: An optimised high-performance liquid chromatographic separation developed for the assay of tioconazole and its potential impurities has been applied to real-world samples where tioconazole is in excess. As severe peak tailing interferes with the assay of two of the impurity peaks, changes in detection wavelength have been examined as a means to discriminate between this interference. The resulting enhancement of resolution has been exploited in the optimisation of analysis time.
authors.forename: A G
authors.initials: AG
authors.lastname: Wright
authors.forename: J C
authors.initials: JC
authors.lastname: Berridge
authors.forename: A F
authors.initials: AF
authors.lastname: Fell
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D007093:Imidazoles / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D007093:Imidazoles; C020527:tioconazole