[Effect of endothelial and smooth muscle cells and the extracellular matrix produced by them on hematopoiesis].
The influence of endothelial and smooth muscle cells and their extracellular matrices on hemopoiesis in long-term bone marrow cultures was investigated. In contract to smooth muscle cells, the enrichment of adherent cell layer with endothelial cells led to the stimulation of hemopoietic cell and granulocyte-macrophage progenitor (CFU-GM) production. The extracellular matrices of both smooth muscle and endothelial cell origin also produced a stimulating effect on the culture, although they were not so effective as endothelial monolayers. The cultures from cryopreserved bone marrow could be established only with the help of endothelial cells or any types of extracellular matrices.
Sadovnikova
E Iu
EIu
Deriugina
E I
EI
Drize
N I
NI
Chertkov
I L
IL
D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D006410:Hematopoiesis; D006801:Humans; D009130:Muscle, Smooth / Q000166:cytology / Q000502:physiology*
Vliianie éndotelial'nykh i gladkomyshechnye kletok i produtsiruemogo imi vnekletochnogo matriksa na krovetvorenie.