Augmentation of human immunodeficiency virus type 1 gene expression by tumor necrosis factor alpha.
It is now well established that cytokines are involved in the regulation of gene expression from HIV-1 LTR. The present study provides evidence that TNF-alpha stimulates HIV-1 gene expression and that the enhancer sequence within the HIV-1 LTR is involved in the stimulation. These results support the idea that immunologic stimulation and infection may trigger the development of clinical AIDS in individuals latently infected with HIV-1.
Okamoto
T
T
Virology Division, National Cancer Center Research Institute, Tokyo, Japan.
Matsuyama
T
T
Mori
S
S
Hamamoto
Y
Y
Kobayashi
N
N
Yamamoto
N
N
Josephs
S F
SF
Wong-Staal
F
F
Shimotohno
K
K
D000818:Animals; D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics; D004742:Enhancer Elements, Genetic / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D010957:Plasmids; D012333:RNA, Messenger / Q000187:drug effects; D012367:RNA, Viral / Q000187:drug effects; D014162:Transfection; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D012333:RNA, Messenger; D012367:RNA, Viral; D014409:Tumor Necrosis Factor-alpha; D015500:Chloramphenicol O-Acetyltransferase