title: Rhinorrhea following dopamine agonist therapy of invasive macroprolactinoma.
abstract: We report on the occurrence of CSF rhinorrhea in a group of 17 patients harbouring macroprolactinomas who were treated with a dopamine agonist (DA, bromocriptine) alone or the combination of DA and transcranial operation. In 2 out of 17 cases shrinkage of tumour remnants during therapy with the oral or injectable form of bromocriptine was responsible for delayed occurrence of rhinorrhea. Operative procedures for successful closure of the fistulae were mandatory in both cases.
authors.affiliation: Department of Neurosurgery, University of Giessen, Federal Republic of Germany.
authors.forename: G
authors.initials: G
authors.lastname: Hildebrandt
authors.forename: J
authors.initials: J
authors.lastname: Zierski
authors.forename: P
authors.initials: P
authors.lastname: Christophis
authors.forename: A
authors.initials: A
authors.lastname: Laun
authors.forename: H
authors.initials: H
authors.lastname: Schatz
authors.forename: I
authors.initials: I
authors.lastname: Lancranjan
authors.forename: N
authors.initials: N
authors.lastname: Klug
mesh_terms: D000328:Adult; D000368:Aged; D001971:Bromocriptine / Q000627:therapeutic use*; D002559:Cerebrospinal Fluid Rhinorrhea / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D015175:Prolactinoma / Q000150:complications / Q000188:drug therapy* / Q000601:surgery
chemical_list: D001971:Bromocriptine