title: A competitive exclusion principle for pathogen virulence.
abstract: For a modified Anderson and May model of host parasite dynamics it is shown that infections of different levels of virulence die out asymptotically except those that optimize the basic reproductive rate of the causative parasite. The result holds under the assumption that infection with one strain of parasite precludes additional infections with other strains. Technically, the model includes an environmental carrying capacity for the host. A threshold condition is derived which decides whether or not the parasites persist in the host population.
authors.affiliation: Department of Biophysics, University of California, Berkeley 94720.
authors.forename: H J
authors.initials: HJ
authors.lastname: Bremermann
authors.forename: H R
authors.initials: HR
authors.lastname: Thieme
mesh_terms: D000818:Animals; D008954:Models, Biological; D010271:Parasites / Q000472:pathogenicity*