title: [Contact allergy to a new preservative].
abstract: A 43 year old woman with no previous skin disease developed contact eczema on the face and neck after application of a lotion used for "smoothing wrinkels", available as a non-prescription item. Patch testing of the product and of one of its ingredients, Euxyl K 400, revealed strong positive reactions. Upon testing of the individual components of the preservative Euxyl K 400, the substance 1,2-dibromo-2,4-dicyanobutane showed a positive reaction even in the concentration of 0.004%. Due to the increasing use of Euxyl K 400 inclusion of the preservative in the patch test battery should be considered.
authors.affiliation: Universitäts-Hautklinik Essen.
authors.forename: H
authors.initials: H
authors.lastname: Senff
authors.forename: M
authors.initials: M
authors.lastname: Exner
authors.forename: J
authors.initials: J
authors.lastname: Görtz
authors.forename: M
authors.initials: M
authors.lastname: Goos
mesh_terms: D000328:Adult; D003358:Cosmetics / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000209:etiology*; D005026:Ethylene Glycols / Q000009:adverse effects*; D005148:Facial Dermatoses / Q000139:chemically induced*; D005260:Female; D006801:Humans; D009570:Nitriles / Q000009:adverse effects*; D010328:Patch Tests; D010592:Pharmaceutic Aids / Q000009:adverse effects*; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*
chemical_list: D003358:Cosmetics; D005026:Ethylene Glycols; D009570:Nitriles; D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical; C039411:1,2-dibromo-2,4-dicyanobutane
vernacular_title: Kontaktallergie auf einen neuen Konservierungsstoff.