The association of posterior capsular lens opacities with bilateral acoustic neuromas in patients with neurofibromatosis type 2.
This study of 47 patients from 11 families with neurofibromatosis type 2 (NF 2) confirms our previously reported association between posterior capsular cataract and NF 2. A highly significant statistical association was found between the presence of posterior capsular lens opacities and the presence of NF 2 as determined by magnetic resonance imaging or pathologic diagnosis. This association was not present for other types of lens opacities that could be the result of age-related or nonspecific changes. When considering the diagnosis of NF 2, this finding now makes it essential to use a careful dilated biomicroscopic examination of the lens to evaluate known, suspected, or at-risk individuals for this potentially early associated manifestation.
Kaiser-Kupfer
M I
MI
Clinical Branch, National Eye Institute, Bethesda, MD 20892.
Freidlin
V
V
Datiles
M B
MB
Edwards
P A
PA
Sherman
J L
JL
Parry
D
D
McCain
L M
LM
Eldridge
R
R
D002386:Cataract / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009464:Neuroma, Acoustic / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D010375:Pedigree; D010781:Photography