Intraventricular administration of neurohypophyseal hormones interferes with the development of tolerance to ethanol.
The effects of intracerebroventricularly (icv.) administered oxytocin (OXT) and lysine-8-vasopressin (LVP) on the development of hypothermic tolerance to ethanol were investigated. Mice equipped with an icv cannula were pretreated with graded doses of OXT or LVP (3 ng, 300 pg, 30 pg or 3 pg/animal) before the daily intraperitoneal ethanol (4 g/kg) injection. Two doses of OXT or LVP (3 ng or 300 pg/animal) blocked the development of hypothermic tolerance to ethanol. Smaller doses of the peptides were ineffective in inhibiting the gradual decrease in hypothermia upon repeated ethanol administration, which effect was observed in the control group. The data presented show that the central administration of these neurohypophyseal peptides blocks the development of tolerance to ethanol.
Szabó
G
G
Department of Pathophysiology, University Medical School, Szeged, Hungary.
Kovács
G L
GL
Telegdy
G
G
D000818:Animals; D001831:Body Temperature; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008236:Lypressin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*
D000431:Ethanol; D010121:Oxytocin; D008236:Lypressin