Histopathology of Lyme arthritis in LSH hamsters.
The authors studied the histopathologic evolution of arthritis in nonirradiated and irradiated hamsters infected with Borrelia burgdorferi. Nonirradiated hamsters injected in the hind paws with B. burgdorferi developed an acute inflammatory reaction involving the synovium, periarticular soft tissues, and dermis. This acute inflammatory reaction was short-lived and was replaced by a mild chronic synovitis as the number of detectable spirochetes in the synovium, periarticular soft tissues, and perineurovascular areas diminished. Exposing hamsters to radiation before inoculation with B. burgdorferi exacerbated and prolonged the acute inflammatory phase. Spirochetes also persisted longer in the periarticular soft tissues. A major histopathologic finding was destructive and erosive bone changes of the hind paws, which resulted in deformation of the joints. These studies should be helpful in defining the immune mechanism participating in the onset, progression, and resolution of Lyme arthritis.
Hejka
A
A
Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison 53706.
Schmitz
J L
JL
England
D M
DM
Callister
S M
SM
Schell
R F
RF
D000818:Animals; D001170:Arthritis, Infectious / Q000473:pathology; D006224:Cricetinae; D005720:Gamma Rays; D006614:Hindlimb; D007596:Joints / Q000473:pathology* / Q000528:radiation effects; D008193:Lyme Disease / Q000473:pathology*; D013583:Synovial Membrane / Q000473:pathology / Q000528:radiation effects