Two sequence-specific binding proteins from the promoter region of the c-Ha-ras-I oncogene.
The role of sequence-specific binding proteins in transcriptional control in higher eukaryotes is unclear. We have investigated the control region of the c-Ha-ras-I protooncogene containing upstream sequences from the transcriptional initiation point. Two proteins, which bind these sequences, with molecular weights of 20 K and 43 K were found. The possible role in the process of transformation is discussed.
Dimitrov
T
T
Institute of General and Comparative Pathology, Bulgarian Academy of Sciences, Sofia.
D000818:Animals; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000502:physiology*; D004591:Electrophoresis, Polyacrylamide Gel; D005786:Gene Expression Regulation; D011905:Genes, ras; D011233:Precipitin Tests; D011401:Promoter Regions, Genetic; D051381:Rats; D015183:Restriction Mapping; D014158:Transcription, Genetic; D014170:Transformation, Genetic
D004268:DNA-Binding Proteins