title: Leiomyosarcoma of the kidney. Immunohistological and ultrastructural findings with special emphasis on the growth fraction.
abstract: This report deals with a case of renal smooth muscle tumour. Considering the low mitotic rate, this neoplasm would have been classified as leiomyoma. However, it displayed a relatively large growth fraction by immunostaining with the monoclonal antibody Ki-67. This led us to the diagnosis "leiomyosarcoma", which is in line with the unfavourable clinical course. We suggest that assessment of the growth fraction with Ki-67 seems to be more objective than the conventional criteria for determining the malignant potential of smooth muscle tumours.
authors.affiliation: Department of Urology, Free University of Berlin, Federal Republic of Germany.
authors.forename: R H
authors.initials: RH
authors.lastname: Krech
authors.forename: V
authors.initials: V
authors.lastname: Loy
authors.forename: K P
authors.initials: KP
authors.lastname: Dieckmann
authors.forename: J
authors.initials: J
authors.lastname: Gerdes
authors.forename: H
authors.initials: H
authors.lastname: Stein
mesh_terms: D000368:Aged; D006801:Humans; D007159:Immunologic Tests; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure; D008297:Male