[Functional activity of the splenic cells in the late periods after the administration of antitumor preparations with various mechanisms of action].
In experiments on CBA/Lac J mice it was found that the course administration of adriamycin (0.95 mg/kg), vinblastine (0.24 mg/kg) and cyclophosphan (27 mg/kg) in 1/10 LD50.10 causes persistent disturbances of the functional activity of the lymphoid tissue manifesting by inhibition of the proliferative response of the spleen lymphocytes to T- and B-cell mitogens one month and to a lesser extent three months after cytostatic action. The lymphotropic effect of adriamycin is due to the predominant damage of the functional activity of T-lymphocytes. Vinblastin suppresses T- and B-cell link of the immunity system and the inhibitory effect of cyclophosphan is directed mainly to B-cell population.
Zapuskalova
O B
OB
Bogdashin
I V
IV
Novitskiĭ
V V
VV
Gol'dberg
E D
ED
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003520:Cyclophosphamide / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D008934:Mitogens / Q000494:pharmacology; D013154:Spleen / Q000166:cytology / Q000187:drug effects*; D013997:Time Factors; D014747:Vinblastine / Q000494:pharmacology
D000970:Antineoplastic Agents; D008934:Mitogens; D014747:Vinblastine; D004317:Doxorubicin; D003520:Cyclophosphamide
Funktsional'naia aktivnost' kletok selezenki v otdalennye sroki posle vvedeniia protivoopukholevykh preparatov s razlichnym mekhanizmom deĭstviia.