[Effect of nucleotide aggregants and anti-aggregants on the coagulation potential of blood plasma].
The authors studied the influence of adenine and pyridine nucleotides on platelet aggregation and on the time of calcium-induced coagulation of citrate plasma, rich or poor in platelets, with deficiency of membrane fragments and its compensation with exogenous small-dispersed tissue thromboplastin. Calcium ions stimulated the conversion of small-dispersed inactive thromboplastin into a larger and more active substance. The antiaggregation agents AMP and NAD+ inhibited inclusion of phospholipid membrane fragments into the process of recalcified plasma coagulation, i.e. expressed an anticoagulant effect, while the aggregation agents (ADP, NADH) intensified their procoagulant action.
Chumakov
V N
VN
Starchik
T G
TG
Siatkovskiĭ
V A
VA
Vasilenko
L P
LP
Kim
O I
OI
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000249:Adenosine Monophosphate / Q000494:pharmacology*; D000925:Anticoagulants; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D003029:Coagulants; D006801:Humans; D066298:In Vitro Techniques; D009243:NAD / Q000494:pharmacology*; D010949:Plasma / Q000187:drug effects* / Q000502:physiology
D000925:Anticoagulants; D003029:Coagulants; D009243:NAD; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate
O vliianii nukleotidnykh agregantov i antiagregantov na koaguliatsionnyĭ potentsial plazmy krovi.