[Further studies of diabetic microangiopathy in children with insulin-dependent diabetes mellitus. Electron microscopy studies].
Electronmicroscopy examinations of the skin vessels were performed in 20 well compensated children with insulin-dependent diabetes mellitus (14 girls and 6 boys ages from 4 to 18 years). The results were compared with 10 healthy ones. In 17 patients the electron-microscopic picture was pathologic, with varying of intensity. Structurally, the most relevant changes were represented by thickening of the basal membrane (in some cases with its multiplication), swelling of endothelial cells, decrease in number of pinocytic vesicules and presence of deposits with increased electron density in the pericarion and the perivascular space. Vascular disturbances may develop very early, sometimes in the first month after manifestation of the disease. The authors suggest, that further investigations are necessary to elucidate the nature of the observed changes. An intensification of insulin therapy would be also considered.
Cisło
M
M
Wasikowa
R
R
Sporniak
M
M
Iwanicka
Z
Z
Słomka
A
A
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000473:pathology*; D003925:Diabetic Angiopathies / Q000473:pathology*; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009131:Muscle, Smooth, Vascular / Q000473:pathology*
Weitere Forschungen zur diabetischen Mikroangiopathie bei Kindern mit insulinabhängigem Diabetes mellitus. Elektronenmikroskopische Untersuchungen.