Penetration of monobactam antibiotics (aztreonam, carumonam) into human prostatic tissue.
Concomitant concentrations of monobactam antibiotics were measured in plasma and in prostatic tissue obtained by transurethral resection in 25 patients, 60-120 min after dosage. A 1-gram single intravenous injection of aztreonam or carumonam yielded mean prostatic concentrations of 6.0 mg/kg in 20 patients. Five patients who received a 2-gram dose of carumonam demonstrated average prostatic levels of 10 mg/kg. These concentrations significantly exceed MIC values for most common gram-negative urinary tract pathogens.
Whitby
M
M
Department of Infectious Diseases, Princess Alexandra Hospital, Brisbane, Australia.
Hempenstall
J
J
Gilpin
C
C
Weir
L
L
Nimmo
G
G
D000368:Aged; D001398:Aztreonam / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011467:Prostate / Q000378:metabolism*
C044145:carumonam; D001398:Aztreonam