Liposomes as cyclosporin A carriers: positively charged lecithin-cholesterol liposomes associated with cyclosporin A do not inhibit biosynthesis of mitochondrial polyglycerophosphatides and microsomal phosphatidylinositol.
Phosphatidylcholine (from egg yolk)-cholesterol-stearylamine (7:2:2.25, molar ratio) liposomes when associated with cyclosporin A (phosphatidylcholine:cyclosporin A = 2:0.07, molar ratio) do not inhibit significantly the biosynthesis of [3H]polyglycerophosphatides and [3H]phosphatidylinositol in mitochondrial and microsomal membranes, respectively, isolated from rat liver. These results are explained by possible protection of the liposomes by cyclosporin A against phospholipase A2 hydrolysis.
Stuhne-Sekalec
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Department of Clinical Biochemistry, Banting Institute, Faculty of Medicine, University of Toronto, Ontario, Canada.
Stanacev
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NZ
D000588:Amines / Q000008:administration & dosage / Q000494:pharmacology; D002784:Cholesterol / Q000008:administration & dosage / Q000494:pharmacology*; D003524:Cyclosporins / Q000008:administration & dosage*; D004337:Drug Carriers; D008081:Liposomes; D008861:Microsomes / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000494:pharmacology*; D010715:Phosphatidylglycerols / Q000096:biosynthesis*; D010716:Phosphatidylinositols / Q000096:biosynthesis*
D000588:Amines; D003524:Cyclosporins; D004337:Drug Carriers; D008081:Liposomes; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D010716:Phosphatidylinositols; C034358:phosphatidylglycerophosphate; D002784:Cholesterol; C009317:stearylamine