The significance of chemically-induced hepatocellular altered foci in rat liver and application to carcinogen detection.
This review describes the pathogenesis and significance of chemically-induced hepatocellular altered foci in rat liver. The measurement of induction of foci can be used for carcinogen detection and the measurement of the modulation of foci by chemicals other than the inducing agent identifies enhancers or inhibitors of liver carcinogenesis.
Williams
G M
GM
American Health Foundation, Valhalla, New York 10595.
D000818:Animals; D015197:Carcinogenicity Tests; D008099:Liver / Q000473:pathology* / Q000648:ultrastructure; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D051381:Rats