First Björn Folkow Award lecture. The role of cardiac output in the control of blood pressure.
Vascular hypertrophy occurs in both primary and secondary hypertension. The degree of hypertrophy is related to the level of blood pressure and its presence can be detected in borderline hypertensives. Hypertrophy causes an increase in resistance to blood flow which is most apparent during exercise. Its presence exaggerates the responses to vasoconstrictor and dilator stimuli and this makes it impossible to estimate vasomotor tone in man. The baroreflex controls variations in blood pressure and, to some extent, the blood pressure level by modifying cardiac output.
Conway
J
J
Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.
D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D001808:Blood Vessels / Q000473:pathology; D002302:Cardiac Output / Q000502:physiology*; D005542:Forearm / Q000098:blood supply; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D006984:Hypertrophy / Q000150:complications / Q000503:physiopathology; D012039:Regional Blood Flow / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology