Effects of occupational exposure and smoking on respiratory symptomatology and PFT in healthy panelists and COPD patients.
A panel of 377 healthy adults and 920 COPD patients aged 30-65 years, is annually interviewed (ATS-NHLI health questionnaire) and performs pulmonary function test (PFT), which includes: FVC, FEV1, FEV1/FVC, PEF, FEF50 and FEF75. Baseline data analysis showed a more significant excess in respiratory symptoms (8.8% to 21.4%) and lower PFT (2.4% to 8.0%) among patients occupationally exposed to dust, than among healthy exposed panelists (-0.7% to 7.7% excess symptomatology and -0.3 to 5.8% lower PFT). Among patients a significant correlation between PFT and degree of occupational dust exposure was found. Significantly lower FEV1/FVC and excess in respiratory symptoms (with relative risks of 2.47-16.38) was present in healthy smokers vs. non smokers as compared with COPD patients.
Goren
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Research Institute for Environmental Health Ministry of Health and Sackler School of Medicine, Tel Aviv, Israel.
Bruderman
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D000328:Adult; D000368:Aged; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D003031:Coal / Q000009:adverse effects; D004391:Dust / Q000009:adverse effects; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000209:etiology*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology*; D011210:Power Plants; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*
D000395:Air Pollutants, Occupational; D003031:Coal; D004391:Dust