title: Impaired venous return causes circulatory failure in experimental pancreatitic shock in dogs.
abstract: The haemodynamic effects in the early phase of canine acute experimental pancreatitis (AP) were studied using a cardiac catheterization technique. AP was induced in anaesthetized dogs with an infusion of trypsin-sodium-taurocholate into the pancreatic duct. The initial haemodynamic measurements were performed after the preparation of the animal and 5 min after the induction of AP. Thereafter, pressure and volume parameters were measured at 10 min intervals. AP induced significant increases in heart rate, dP/dtmax and mean arterial pressure, but a decrease in Vmax 5 min after the induction of AP. After the initial phase, the heart rate remained significantly increased, while constant and significant decreases of stroke volume, cardiac output, end-diastolic volume and end-diastolic pressure developed. The parameters of the contractility of the left ventricle were not affected to the same extent. It is suggested that the circulatory failure observed in AP, characterised by a prompt reduction of cardiac output, was primarily due to a heavy reduction in preload. This supports the theory that cardiac output is primarily affected by impaired venous return with consequently decreased preload rather than by a loss of ventricular contractility. Hence, the existence of a myocardial depressant factor in the early phase of experimental AP does not gain support from the present results.
authors.affiliation: Department of Anatomy, University of Oulu, Finland.
authors.forename: O J
authors.initials: OJ
authors.lastname: Rämä
authors.forename: P
authors.initials: P
authors.lastname: Rämö
authors.forename: M
authors.initials: M
authors.lastname: Karhunen
authors.forename: H
authors.initials: H
authors.lastname: Kiviniemi
authors.forename: R
authors.initials: R
authors.lastname: Kettunen
mesh_terms: D000208:Acute Disease; D000818:Animals; D004285:Dogs; D006439:Hemodynamics; D009201:Myocardial Depressant Factor / Q000502:physiology; D010195:Pancreatitis / Q000150:complications / Q000503:physiopathology*; D012770:Shock, Cardiogenic / Q000209:etiology* / Q000503:physiopathology
chemical_list: D009201:Myocardial Depressant Factor