[Changes in radiation lesions using platinum derivatives. Biological bases and clinical experience].
The biological basis of radiation damage modulation with platinum derivatives are reviewed. Cisplatin and Carboplatin are cytostatic agents used increasingly in the treatment of different human tumours. In vitro and in vivo studies have established the interest of the simultaneous combination of platinum compounds and radiation in tumor cells and neoplastic tissue, describing potentiation, sensitization, and inhibition of sublethal damage repair effects from radiation. Clinical trials have been recently activated in order to explore a possible benefit from the biological modulation with platinum compounds of radiotherapy. In the frame of developmental therapeutic protocols in modern oncology, this approach might explore a positive effect on the therapeutic index of radiotherapy for malignant tumors. The initial clinical results reported indicate that the available platinum derivatives used in human oncology behave as radiopotentiating and radiosensitizing agents.
Calvo
F A
FA
Departamento de Oncología, Facultad de Medicina, Universidad de Navarra, Pamplona, España.
Ortiz de Urbina
D
D
Abuchaibe
O
O
Aristu
J
J
Santos
M
M
D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy; D015687:Cell Hypoxia; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents
D011838:Radiation-Sensitizing Agents; D002945:Cisplatin
Modificación de la lesión por radiación con derivados de platino. Bases biológicas y experiencias clínicas.