title: Use of 31P magnetic resonance spectroscopy to characterize evolving brain damage after perinatal asphyxia.
abstract: We investigated postasphyxial brain damage with 31P magnetic resonance spectroscopy (MRS) and correlated it with neurologic assessment and standard laboratory evaluation during the first 10 months of life in 1 infant, baby G. We compared these observations to 31P MRS data from 7 healthy term newborns, 1 normal infant examined serially over the first 8.5 months of life, and 5 other term infants following perinatal asphyxia. MRS noninvasively provides biochemical correlates of the evolution of brain damage following perinatal asphyxia and suggests that pH derived from the inorganic phosphate peak may serve as a marker for brain injury.
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063.
authors.forename: A R
authors.initials: AR
authors.lastname: Laptook
authors.forename: R J
authors.initials: RJ
authors.lastname: Corbett
authors.forename: R
authors.initials: R
authors.lastname: Uauy
authors.forename: C
authors.initials: C
authors.lastname: Mize
authors.forename: D
authors.initials: D
authors.lastname: Mendelsohn
authors.forename: R L
authors.initials: RL
authors.lastname: Nunnally
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications*; D001921:Brain / Q000473:pathology; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005311:Fetal Hypoxia / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D010758:Phosphorus; D011247:Pregnancy; D012016:Reference Values
chemical_list: D010758:Phosphorus