Uroporphyrinogen decarboxylase and porphyrins in the tissue of human clear-cell renal carcinoma and in its maternal renal cortex.
The activity of uroporphyrinogen decarboxylase and porphyrin concentration were determined in human clear-cell renal carcinomas and in their maternal renal cortex without evidence of malignancy in 24 men and 8 women. The obtained results were compared with the degree of morphological malignancy of various tumors. No positive correlation was found between the activity of uroporphyrinogen decarboxylase and the concentration of porphyrins in the studied tissues. There was no significant correlation between the activity of this enzyme and the porphyrin level and the degree of morphological malignancy of the tumors. However, in most cases the combined concentrations of three porphyrin fractions (uroporphyrin, coproporphyrin and protoporphyrin) were lower in carcinomas than in the unchanged renal cortex of the same kidney.
Zawirska
B
B
Department of Pathological Anatomy, Medical Academy of Wrocław, Poland.
D014408:Biomarkers, Tumor / Q000032:analysis; D002262:Carboxy-Lyases / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000032:analysis* / Q000201:enzymology / Q000473:pathology; D005260:Female; D006801:Humans; D007672:Kidney Cortex / Q000032:analysis* / Q000201:enzymology; D007680:Kidney Neoplasms / Q000032:analysis* / Q000201:enzymology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011166:Porphyrins / Q000032:analysis*; D012737:Sex Factors; D014575:Uroporphyrinogen Decarboxylase / Q000378:metabolism*
D014408:Biomarkers, Tumor; D011166:Porphyrins; D002262:Carboxy-Lyases; D014575:Uroporphyrinogen Decarboxylase