A close relationship between microvilli and metabolic cooperation deficiency in embryonal carcinoma cells.
A revertant clone has been isolated from the metabolic cooperation-deficient embryonal carcinoma clone PT2md1. In PT2md1, its cooperation-competent parent, and its cooperation-competent revertant an inverse correlation has been demonstrated between cooperation competence and the incidence of microvilli. This demonstration, together with a similar correlation previously reported in an independently isolated series of cell lines, establishes a close causal relationship between the incidence of microvilli and communication deficiency.
Purcell
I F
IF
Department of Pathology, University Medical School, Edinburgh, Scotland.
Smith
T A
TA
Patek
C E
CE
Hooper
M L
ML
D000818:Animals; D002450:Cell Communication; D007365:Intercellular Junctions / Q000502:physiology*; D008871:Microvilli / Q000502:physiology*; D013499:Surface Properties; D013724:Teratoma / Q000378:metabolism* / Q000648:ultrastructure; D014407:Tumor Cells, Cultured