Sensitivity of ERG components from dark-adapted goldfish retinas treated with APB.
The electroretinogram (ERG) of the dark-adapted goldfish was examined before and after intravitreal injection of DL-2-amino-4-phosphonobutyric acid (APB). APB abolished the b-wave and decreased absolute sensitivity of the remaining waveform, which was composed of a vitreal-negative component followed by a vitreal-positive component. The sensitivity, time course and amplitude of these components differed from ERGs obtained from animals treated with sodium aspartate. Spectral sensitivity of both post-APB components closely resembled that of the normal dark-adapted b-wave. The results suggest that APB does not act selectively on any particular class of photoreceptors or photoreceptor pathways in the dark-adapted goldfish retina.
DeMarco
P J
PJ
Department of Psychology, Vanderbilt University, Nashville, TN 37240.
Powers
M K
MK
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology; D003530:Cyprinidae / Q000502:physiology*; D003624:Darkness; D006054:Goldfish / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D010775:Photic Stimulation; D012160:Retina / Q000187:drug effects / Q000502:physiology*; D012684:Sensory Thresholds / Q000187:drug effects
D000613:Aminobutyrates; D001224:Aspartic Acid; C012729:2-amino-4-phosphonobutyric acid