Opossum insulin, glucagon and pancreatic polypeptide: amino acid sequences.
Pancreatic hormones have been purified from the opossum, a New World marsupial. Opossum insulin contains a Leu substitution at the N-terminus of the B-chain in place of the Phe that is generally present in mammalian insulins. In addition, there are two other amino acid substitutions in the opossum insulin A-chain (positions 8 and 18) compared to pig insulin. Opossum glucagon is identical to chicken glucagon with both differing from the usual mammalian glucagon by Ser in place of Asn at its penultimate C-terminal position. Opossum PP differs from the porcine peptide in only 3 sites (position 3, 19 and 30).
Yu
J H
JH
Solomon A. Berson Research Laboratory, Veterans Administration Medical Center, Bronx, NY 10468.
Eng
J
J
Rattan
S
S
Yalow
R S
RS
D000595:Amino Acid Sequence; D000818:Animals; D005934:Glucagon / Q000302:isolation & purification; D007328:Insulin / Q000302:isolation & purification; D008322:Mammals; D008969:Molecular Sequence Data; D009893:Opossums; D010191:Pancreatic Polypeptide / Q000302:isolation & purification; D011863:Radioimmunoassay; D013045:Species Specificity; D013552:Swine
D007328:Insulin; D010191:Pancreatic Polypeptide; D005934:Glucagon