Effect of chloride on blood pressure and sympathetic nervous system activity in deoxycorticosterone acetate-treated rats.
The effect of selective chloride loading on blood pressure and sympathetic nervous system activity was studied in deoxycorticosterone acetate (DOCA)-treated rats. The rats fed a normal sodium-high chloride and fed a high sodium chloride diet had higher blood pressure and lower cardiac norepinephrine concentrations than those fed a normal sodium chloride diet. Furthermore, cardiac norepinephrine concentrations were significantly correlated with systolic blood pressure. These data suggest that selective chloride loading can raise blood pressure in DOCA-treated rats due to augmented sympathetic nervous system activity.
Miki
T
T
First Department of Internal Medicine, Kobe University School of Medicine, Japan.
Sano
H
H
Suzuki
H
H
Kawahara
J
J
Hattori
K
K
Saito
K
K
Furuta
Y
Y
Fukuzaki
H
H
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000097:blood; D002712:Chlorides / Q000494:pharmacology*; D003900:Desoxycorticosterone / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000187:drug effects*
D002712:Chlorides; D003900:Desoxycorticosterone; D002118:Calcium; D009638:Norepinephrine