[Regulation of the RNAse activity of the saliva in healthy subjects and in stomach cancer].
Acidic and alkaline RNase activity from healthy humans and gastric cancer patients has been studied. A decrease in daily saliva production and an increase in RNase activity was detected saliva of cancer patients. This suggests the existence of RNase inhibitors in healthy humans. This supposition is further confirmed by comparative analysis of total, joint fractional and reconstituted RNase activity. A considerable increase in acidic RNase inhibitors and disappearance of alkaline RNase inhibitor was observed in cancer patients. The specificity, mechanisms and clinical significance of this phenomena has been discussed.
Kharchenko
S V
SV
Shpakov
A A
AA
D002940:Circadian Rhythm; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012260:Ribonucleases / Q000032:analysis* / Q000037:antagonists & inhibitors; D012463:Saliva / Q000032:analysis / Q000201:enzymology*; D012471:Salivary Proteins and Peptides / Q000032:analysis; D013274:Stomach Neoplasms / Q000201:enzymology*
D012471:Salivary Proteins and Peptides; D012260:Ribonucleases
Izuchenie reguliatsii aktivnosti RNKaz rotovoĭ zhidkosti u zdorovykh liudeĭ i pri rake zheludke.