title: Use of caffeine in the treatment of apnea associated with the Arnold-Chiari malformation.
abstract: The occurrence of significant apnea has been reported in infants with Arnold-Chiari malformation (ACM). We report 1 infant with ACM and severe apnea treated with caffeine therapy. There was a marked decrease in apnea frequency, less variability in breathing patterns, and a shift to the left of the CO2 response curve with caffeine. Our findings in 1 infant suggest that caffeine may be an effective adjunct in the treatment of apnea associated with ACM.
authors.affiliation: Developmental Pharmacology and Perinatal Research Unit, Montreal Children's Hospital Research Institute, Que., Canada.
authors.forename: J M
authors.initials: JM
authors.lastname: Davis
authors.forename: R
authors.initials: R
authors.lastname: Zinman
authors.forename: J V
authors.initials: JV
authors.lastname: Aranda
mesh_terms: D001139:Arnold-Chiari Malformation / Q000150:complications*; D002110:Caffeine / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012891:Sleep Apnea Syndromes / Q000188:drug therapy* / Q000209:etiology
chemical_list: D002110:Caffeine