Chromosomal aberrations in bone marrow and peripheral blood cells from the same rats.
Spontaneous cytogenetic aberrations were analyzed in bone-marrow cells and cultured peripheral lymphocytes from the same animals. No significant differences in the total number of cells with aberrations or total aberrations were detected between the bone-marrow cells and cultured lymphocytes. It was concluded that short-term culture does not contribute significantly to in vivo aberration yield within the experimental conditions used.
Sinha
A K
AK
Lake Jackson Research Center, Dow Chemical Company, Freeport, TX 77541.
Linscombe
V A
VA
Gollapudi
B B
BB
D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D008677:Metaphase; D051381:Rats; D011919:Rats, Inbred Strains