Effects of some antidepressant drugs on the activity of glial cell enzymes in culture.
An oligodendrocyte-enriched culture was incubated with the antidepressant drugs, amitriptyline, desipramine, mianserin and citalopram, in a concentration of 3 X 10(-6) M for 24 h and 14 days. The activity of glycerol-3-phosphate dehydrogenase (G3PDH), lactate dehydrogenase (LDH), pyruvate carboxylase (PC) and the incorporation of [3H]thymidine was measured. An increase in both the incorporation of [3H]thymidine into DNA and the activities of G3PDH and PC was observed. However, LDH activity decreased after a 2-week incubation. The above results indicate that the antidepressant drugs change the metabolism of glial cells.
Bal-Klara
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Institute of Pharmacology, Polish Academy of Sciences, Poland.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D009457:Neuroglia / Q000201:enzymology*; D009836:Oligodendroglia / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D000928:Antidepressive Agents; D004247:DNA; D005954:Glucosephosphate Dehydrogenase; D013936:Thymidine