title: Water suppression with B0 field gradient homospoil pulses in high-resolution NMR spectroscopy.
abstract: The combination of a frequency nonselective excitation suppression method (1331 sequence) with selective excitation followed by gradient-induced dephasing of water transverse magnetization yielded suppression ratios of greater than 10,000:1. The need for gradient preemphasis and correction of B0 field shifts is discussed. The suppression efficiency of this method compared favorably to results obtained using the CPMG spin-echo technique to observe metabolite resonances in a urine sample.
authors.affiliation: Department of Chemistry, University of Queensland, St. Lucia, Australia.
authors.forename: I M
authors.initials: IM
authors.lastname: Brereton
authors.forename: J
authors.initials: J
authors.lastname: Field
authors.forename: L N
authors.initials: LN
authors.lastname: Moxon
authors.forename: M G
authors.initials: MG
authors.lastname: Irving
authors.forename: D M
authors.initials: DM
authors.lastname: Doddrell
mesh_terms: D004867:Equipment Design; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D014556:Urine / Q000032:analysis; D014867:Water
chemical_list: D014867:Water