Diabetes mellitus type I. The present and the future.
Insulin dependent diabetes is an organ specific immunologic disease caused by pancreatic B cell destruction, mediated by T lymphocytes Present knowledge about insulin dependent diabetes immunogenetics and their relationship with the HLA system is reviewed, highlighting the polymorphism of the D area of that system and its connectors with diabetes. Possible therapeutic interventions in the autoimmune destructive process are discussed.
Barbosa
J
J
Santamaria
P
P
D015551:Autoimmunity; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000209:etiology / Q000235:genetics / Q000276:immunology; D003925:Diabetic Angiopathies / Q000150:complications*; D020022:Genetic Predisposition to Disease; D006681:HLA-D Antigens / Q000235:genetics*; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology
D006681:HLA-D Antigens