title: [Effect of brain extracts from rats subjected to korazol kindling on generalized epileptic activity].
abstract: The pharmacological kindling was induced in rats by corazol repeated injections in subthreshold doses. The peptide-containing fraction was emitted from animal brains by the help of hot acetic acid on the stage of generalized clonic-tonic seizures development. Intraperitoneal injection of brain extracts of kindled rats significantly increased corazol and picrotoxin induced seizure severity in mice. The effect was removed by preliminary injection of naloxone or by preventive incubation of extracts with pronase. Intraventricular injection of extracts to intact rats increased the seizure severity which was provoked by corazol and in high doses induced in rats generalized seizure reactions.
authors.forename: G N
authors.initials: GN
authors.lastname: Kryzhanovskiĭ
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Karganov
authors.forename: A A
authors.initials: AA
authors.lastname: Shandra
authors.forename: L S
authors.initials: LS
authors.lastname: Godlevskiĭ
authors.forename: V K
authors.initials: VK
authors.lastname: Lutsenko
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D004347:Drug Interactions; D004827:Epilepsy / Q000139:chemically induced* / Q000503:physiopathology; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009270:Naloxone / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010455:Peptides / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009270:Naloxone; D010433:Pentylenetetrazole; D010455:Peptides; D010852:Picrotoxin
vernacular_title: Vliianie ékstraktov mozga krys, podvergshikhsia korazolovomu kindlingu, na generalizovannuiu épilepticheskuiu aktibnost'.