title: [Role of the contact plasma system in human physiopathology].
abstract: The possible implications of the plasma contact system in several human pathological conditions have been reviewed. The mechanism of activation and the biochemistry of the different components of this physiological system are described. The activation of the plasma contact system and its important physiological consequences are considered. The implication of the plasma contact system in the pathogenesis of different human and experimental pathological conditions (shock, disseminated intravascular coagulation, extracorporeal circulation...) is reviewed. A particular consideration is given to the pathogenesis of glomerulonephritis where the plasma contact system has been more directly implicated.
authors.affiliation: Servicio de Inmunología, Facultad de Medicina, Universidad de Navarra, Pamplona, España.
authors.forename: A
authors.initials: A
authors.lastname: Sánchez-Ibarrola
authors.forename: J
authors.initials: J
authors.lastname: Villaro
authors.forename: M L
authors.initials: ML
authors.lastname: Subirá
mesh_terms: D005172:Factor XI / Q000502:physiology*; D005174:Factor XII / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007704:Kininogens / Q000502:physiology*; D011288:Prekallikrein / Q000502:physiology*; D013499:Surface Properties
chemical_list: D007704:Kininogens; D005174:Factor XII; D005172:Factor XI; D011288:Prekallikrein
vernacular_title: Papel del sistema de contacto plasmático en la fisiopatología humana.