title: Synthesis and antiinflammatory/analgesic activities of N-heterocyclic carboxamides of thiopyrano-1,2-benzothiazine.
abstract: We report the synthesis of N-heterocyclic carboxamides of 5-methyl-4-oxo-2,3,4,5-tetrahydrothiopyrano [3,2-c][1,2]benzothiazine 6,6-dioxide, their antiinflammatory and analgesic activities and the attempts to obtain a corresponding sulfoxidate series. Compounds (II c) and (II l) showed a good antiinflammatory activity which is comparable to that of piroxicam. No compound showed any significant analgesic activity.
authors.affiliation: Istituto di Chimica Farmaceutica, Università di Perugia.
authors.forename: F
authors.initials: F
authors.lastname: Schiaffella
authors.forename: R
authors.initials: R
authors.lastname: Fringuelli
authors.forename: V
authors.initials: V
authors.lastname: Cecchetti
authors.forename: A
authors.initials: A
authors.lastname: Fravolini
authors.forename: G
authors.initials: G
authors.lastname: Bruni
authors.forename: F M
authors.initials: FM
authors.lastname: Runci
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D010084:Oxidation-Reduction; D010894:Piroxicam / Q000494:pharmacology; D011714:Pyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D013440:Sulfides / Q000138:chemical synthesis / Q000494:pharmacology; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006571:Heterocyclic Compounds; D011714:Pyrans; D013440:Sulfides; D013843:Thiazines; D010894:Piroxicam