title: Cytogenetic studies on three pheochromocytomas derived from patients with von Hippel-Lindau syndrome.
abstract: Chromosomal analyses of three pheochromocytomas from patients with von Hippel-Lindau syndrome are reported. One pheochromocytoma revealed a normal karyotype, another tumor showed a trisomy 7 as the only chromosomal abnormality, whereas in a further sample a polyclonal chromosome constitution was detected. In addition to a normal 46,XX cell line, four distinct chromosomally abnormal cell lines could be identified. One cell line revealed partial trisomy for the long arm of chromosome 1 and additionally exhibited the phenomenon of telomeric association. Most interestingly, three further cell clones showed rearrangements of chromosome 3 including the region where the von Hippel-Lindau gene was mapped; three rearrangements resulted in a partial or total trisomy of 3p. Our findings are discussed in relation to previously reported cytogenetic and molecular results regarding von Hippel-Lindau syndrome.
authors.affiliation: Institut für Humangenetik und Anthropologie, Universität, Freiburg, Federal Republic of Germany.
authors.forename: M
authors.initials: M
authors.lastname: Kiechle-Schwarz
authors.forename: H P
authors.initials: HP
authors.lastname: Neumann
authors.forename: H J
authors.initials: HJ
authors.lastname: Decker
authors.forename: C
authors.initials: C
authors.lastname: Dietrich
authors.forename: B
authors.initials: B
authors.lastname: Wullich
authors.forename: W
authors.initials: W
authors.lastname: Schempp
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000235:genetics*; D000328:Adult; D000798:Angiomatosis / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000648:ultrastructure*; D005134:Eye Neoplasms / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D010673:Pheochromocytoma / Q000235:genetics*; D014407:Tumor Cells, Cultured; D006623:von Hippel-Lindau Disease / Q000235:genetics*