title: A gene homologous to plasminogen located on human chromosome 2q11-p11.
abstract: A plasminogen probe encoding kringles 1-3 detects homologous loci on human chromosomes 6 and 2 by somatic cell hybrid analysis. Regional localization by in situ hybridization places the loci at 6q26-27 and 2p11-q11. Further analysis by varying washing stringencies of hybridization filters reveals a greater homology with the chromosome 6 locus than with the chromosome 2 locus. These results confirm localization of the plasminogen gene to human chromosome 6q26-27 and indicate that a homologous sequence of unknown identity resides on chromosome 2p11-q11.
authors.affiliation: Department of Microbiology, School of Medicine, University of California, Los Angeles 90024.
authors.forename: S L
authors.initials: SL
authors.lastname: Frank
authors.forename: I
authors.initials: I
authors.lastname: Klisak
authors.forename: R S
authors.initials: RS
authors.lastname: Sparkes
authors.forename: A J
authors.initials: AJ
authors.lastname: Lusis
mesh_terms: D002889:Chromosomes, Human, Pair 2; D002896:Chromosomes, Human, Pair 6; D015342:DNA Probes; D006801:Humans; D009693:Nucleic Acid Hybridization; D010958:Plasminogen / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D015342:DNA Probes; D010958:Plasminogen