Effects of steroid anaesthesia on some liver function tests in goats.
The effect of Saffan, a steroid anaesthetic, on the liver function of goats has been studied. Forty healthy animals were divided into 4 equal groups. The first 2 groups were given 2 and 4 mg Saffan/kg b. wt respectively. A mixture of Saffan (1 mg) and Xylazine (0.1 mg)/kg b. wt was given to the third group and Xylazine alone to the fourth group (0.1 mg/kg b. wt). Serum samples from all groups were analysed for glucose, total protein, total and direct bilirubin and the level of activity of transaminases. Administration of Saffan evoked more hyperglycemia than a mixture with Xylazine, or Xylazine alone. The hyperglycemic effect of both doses of Saffan (2 and 4 mg) was equivocal beyond 2 h. The effect then differed and glucose was increased 4-fold by 2 mg and 3-fold by 4 mg Saffan. Serum total protein, conjugated and total bilirubin, and GPT and GOT were not changed in the four experimental groups. This was good evidence of a normally functioning liver during the course of steroid anaesthesia administration in goats.
Amer
H A
HA
Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Ahmed
A S
AS
Gohar
H M
HM
Abdel Mamid
M A
MA
D000410:Alanine Transaminase / Q000097:blood; D000530:Alfaxalone Alfadolone Mixture / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D006041:Goats; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D008297:Male; D014991:Xylazine / Q000494:pharmacology
D001786:Blood Glucose; D001798:Blood Proteins; D014991:Xylazine; D000530:Alfaxalone Alfadolone Mixture; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin