ATH-3, a new gene for atherosclerosis in the mouse.
Mice derived from resistant A/J (A) and susceptible C57BL/6J (B) strains have been used to study the genetics of diet-induced atherosclerosis. A comparison of lesion scores between the parental strains, the F1 offspring of A x B and B x A matings and the offspring of (B x A)F1 hybrids backcrossed to either parent strain, indicates that a single major gene with alleles for resistance and susceptibility is responsible for the difference in response of A/J and C57BL/6J mice to a high fat, high cholesterol diet. By comparing the strain distribution pattern of susceptibility with known genetic markers in 30 A x B and B x A recombinant inbred (RI) strains, this gene, designated Ath-3, has been mapped close to a coat colour gene, c, on chromosome 7. Although a single gene may be primarily responsible for the difference in susceptibility to diet-induced atherosclerosis in these mice, the results of the breeding experiments indicate that its expression is probably modified by one or more additional genes.
Stewart-Phillips
J L
JL
Montreal General Hospital Research Institute, Quebec.
Lough
J
J
Skamene
E
E
D000818:Animals; D001011:Aorta / Q000473:pathology*; D001161:Arteriosclerosis / Q000235:genetics*; D003433:Crosses, Genetic; D004036:Diet, Atherogenic; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D008805:Mice, Inbred A / Q000235:genetics*; D008810:Mice, Inbred C57BL / Q000235:genetics*