Involvement of chromosome 22 in a Merkel cell carcinoma in a patient with a previous meningioma.
The relatively simple cytogenetic findings in an aggressive metastatic Merkel cell carcinoma are reported. Deletion 2p was found in 100% of the cells. Nevertheless, this was considered a secondary (metastatic?) change because the same aberration has been found in several other kinds of malignancy. The involvement of chromosome 22 [del(22q) and -22] in 85% of the cells seemed more intriguing, considering the fact that the Merkel cell carcinoma followed a previous meningioma.
Shabtai
F
F
B. Gattegno Research Institute, Hasharon Hospital, Golda Medical Center, Petach Tikva, Israel.
Sternberg
A
A
Klar
D
D
Reiss
R
R
Halbrecht
I
I
D015266:Carcinoma, Merkel Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics*; D008579:Meningioma / Q000235:genetics*; D008875:Middle Aged