[Extreme hypogammaglobulinemia disclosing large granular lymphocytes with hepatosplenorenal infiltration].
We report a case of large granular lymphocytosis, or chronic "natural killer" lymphocytosis, a newly described entity. We were able to demonstrate the proliferative character of the disease by the finding of karyotype abnormalities. This case was remarkable for the pre-existence, for at least three years, of severe hypogammaglobulinaemia, for the very slow course of the proliferative process and for the progressive and tumoral infiltration of the spleen and liver, then kidney.
Harlé
J R
JR
Clinique médicale B, hôpital de la Timone, Marseille.
Quinsat
D
D
Durand
J M
JM
Horchowski
N
N
Nicolino
M
M
Kaplanski
S
S
Farnarier
C
C
Fossat
C
C
Mongin
M
M
Weiller
P J
PJ
D000361:Agammaglobulinemia / Q000209:etiology*; D006801:Humans; D007680:Kidney Neoplasms / Q000556:secondary; D007694:Killer Cells, Natural / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000150:complications*; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D013160:Splenic Neoplasms / Q000556:secondary; D013997:Time Factors
Hypogammaglobulinémie extrême révélant une leucémie à grands lymphocytes granuleux avec infiltration hépato-spléno-rénale.