Effects of preoptic area lesions on muramyl dipeptide-induced sleep and fever.
Lesions of the preoptic area of rabbits caused hyperthermia, although they did not alter sleep-coupled changes in brain temperature, and reduced slow-wave sleep, rapid eye movement sleep, and amplitudes of electroencephalographic slow waves during slow wave sleep. The direction and magnitude of the muramyl dipeptide-induced responses were similar before and after the lesions, although the baseline values upon which the changes were superimposed had shifted.
Shoham
S
S
Department of Physiology and Biophysics, University of Tennessee, Memphis 38163.
Blatteis
C M
CM
Krueger
J M
JM
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D004569:Electroencephalography; D005334:Fever / Q000503:physiopathology*; D008297:Male; D011301:Preoptic Area / Q000502:physiology* / Q000503:physiopathology; D011817:Rabbits; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D012894:Sleep Stages / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D000119:Acetylmuramyl-Alanyl-Isoglutamine