Failure to immortalise human AML cells using human recombinant GMCSF in vitro and in vivo.
We have failed to find any evidence that human recombinant GM-CSF can immortalize human AML cells grown in liquid culture or as nodules in immune deprived mice. In previous clinical studies and a controlled trial currently underway there is no evidence of irreversible acceleration of the disease.
Clutterbuck
R
R
Leukaemia Unit, Royal Marsden Hospital, Sutton, U.K.
Newman
A
A
Powles
R
R
Kwong
Y
Y
Millar
J
J
Shepherd
V
V
Smith
C
C
D000818:Animals; D016026:Bone Marrow Transplantation; D002455:Cell Division / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000009:adverse effects* / Q000627:therapeutic use; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000009:adverse effects* / Q000627:therapeutic use; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D016032:Randomized Controlled Trials as Topic
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016178:Granulocyte-Macrophage Colony-Stimulating Factor