title: Assignment of the human intestinal Na+/glucose cotransporter gene (SGLT1) to the q11.2----qter region of chromosome 22.
abstract: The chromosomal location of the human intestinal Na+/glucose cotransporter gene (SGLT1) was determined using human cDNA and genomic probes for this transporter gene. Southern blot analysis of genomic DNA from 15 mouse-human somatic cell hybrids showed that the human gene for this transporter resides on chromosome 22. Analysis of hamster-human hybrids selectively retaining chromosome 22 or a portion of it allowed specific assignment of the locus to the q11.2----qter region of chromosome 22. A restriction fragment length polymorphism was identified with EcoRI.
authors.affiliation: Department of Physiology, UCLA School of Medicine 90024-1751.
authors.forename: M A
authors.initials: MA
authors.lastname: Hediger
authors.forename: M L
authors.initials: ML
authors.lastname: Budarf
authors.forename: B S
authors.initials: BS
authors.lastname: Emanuel
authors.forename: T K
authors.initials: TK
authors.lastname: Mohandas
authors.forename: E M
authors.initials: EM
authors.lastname: Wright
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22 / Q000648:ultrastructure; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009004:Monosaccharide Transport Proteins / Q000235:genetics*
chemical_list: D009004:Monosaccharide Transport Proteins