title: [Acute peptic lesions of the gastroduodenal mucosa in patients with obstructive jaundice].
abstract: Complex study of the gastric acid-producing activity, the condition of the gastroduodenal mucosa, and the serum gastrin concentration in 80 patients with obstructive jaundice showed that the appearance of acute erosive-ulcerative injuries of the mucosa of the gastroduodenal zone depended on the increase of activity of the peptic factor of the gastric medium. Peptic complications occurred in 27.1% of patients with initial normo and hyperacidity and a high level of blood gastrin. The absence of bile in the duodenum (obstructive jaundice, by-pass biliodigestive anastomoses) stimulated the peptic factor. This is evidently linked with secretin deficiency (absence of the effect of bile on the secretin producing S-cells) leading to weakened inhibiting effect of secretin on the serum gastrin content, which results in hypergastrinemia and hyperacidity.
authors.forename: A V
authors.initials: AV
authors.lastname: Upyrev
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Gusev
authors.forename: V A
authors.initials: VA
authors.lastname: Il'ichev
authors.forename: V K
authors.initials: VK
authors.lastname: Gorchakov
authors.forename: O A
authors.initials: OA
authors.lastname: Muratova
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002779:Cholestasis / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000209:etiology*
vernacular_title: Ostrye pepticheskie porazheniia slizistoĭ gastroduodenal'noĭ zony u bol'nykh s obturatsionnoĭ zheltukhoĭ.