Induction of gastric cancer in monkeys by N-methyl-N-nitro-N-nitrosoguanidine (MNNG).
N-methyl-N-nitro-N-nitrosoguanidine (MNNG) was administered to 9 Macaca fascicularis monkeys (7 males and 2 females) through a tube at a dose of 40 mg/kg body weight 3 times a month. Tumors of the pyloric part of the stomach were observed in 2 male monkeys after MNNG doses of 800 and 848 mg/kg body weight, with a latent period of tumor development of 49 and 50 weeks, respectively. Histologically, in one case the tumor was a solid carcinoma, and in the other it had a mixed structure showing alternating solid and signet ring cell carcinoma areas.
Sharashidze
L K
LK
Oncological Research Center, Ministry of Health of the Georgian SSR, Tbilisi.
Beniashvili
D Sh
DSh
Sherenesheva
N I
NI
Turkia
N G
NG
D000818:Animals; D005260:Female; D008252:Macaca fascicularis; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology
D008769:Methylnitronitrosoguanidine