Hepatoprotective effects of Wedelia calendulacea.
The alcoholic extract of whole plant Wedelia calendulacea exhibited protective activity against carbon tetrachloride-induced liver injury in vivo. The extract also increased the bile flow in rats suggesting a stimulation of liver secretory capacity. The minimum lethal dose was greater than 200 mg/kg p.o. in mice.
Sharma
A K
AK
Regional Research Laboratory, Jammu, India.
Anand
K K
KK
Pushpangadan
P
P
Chandan
B K
BK
Chopra
C L
CL
Prabhakar
Y S
YS
Damodaran
N P
NP
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors / Q000633:toxicity; D006591:Hexobarbital / Q000037:antagonists & inhibitors / Q000633:toxicity; D007194:India; D008099:Liver / Q000187:drug effects* / Q000293:injuries; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D051379:Mice; D010946:Plants, Medicinal; D011517:Prothrombin Time; D051381:Rats; D012018:Reflex / Q000187:drug effects; D013448:Sulfobromophthalein / Q000493:pharmacokinetics
D013448:Sulfobromophthalein; D006591:Hexobarbital; D002251:Carbon Tetrachloride