Calicheamicin gamma 1I and DNA: molecular recognition process responsible for site-specificity.
Calicheamicin gamma 1I is a recently discovered diyne-ene-containing antitumor antibiotic that cleaves DNA in a double-stranded fashion, a rarity among drugs, at specific sequences. It is proposed that the cutting specificity is due to a combination of the complementarity of the diyne-ene portion of the aglycone with DNA secondary structures and stabilization by association of the thiobenzoate-carbohydrate tail with the minor groove.
Zein
N
N
Cyanamid Company, Medical Research Division, Lederle Laboratories, Pearl River, NY 10965.
Poncin
M
M
Nilakantan
R
R
Ellestad
G A
GA
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D000903:Antibiotics, Antineoplastic; D001483:Base Sequence; D001565:Benzoates; D001665:Binding Sites; D002241:Carbohydrates; D002417:Cattle; D003198:Computer Simulation; D004247:DNA / Q000378:metabolism*; D053281:Enediynes; D008958:Models, Molecular; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D013329:Structure-Activity Relationship
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001565:Benzoates; D002241:Carbohydrates; D053281:Enediynes; C055955:calicheamicin gamma(1)I; D004247:DNA