title: Estrogens and the pathophysiology of Parkinson's disease.
abstract: Two postmenopausal female Parkinsonian patients experienced exacerbation of symptoms including levodopa-induced "On-Off" following withdrawal or reduction of conjugated estrogen therapy. This report supports animal data implicating female sexual hormones in the pathophysiology of Parkinson's disease and levodopa-induced dyskinesias.
authors.affiliation: Department of Neurology, University of Arizona, Tucson 85724.
authors.forename: R
authors.initials: R
authors.lastname: Sandyk
mesh_terms: D004967:Estrogens / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D004967:Estrogens; D007980:Levodopa