title: Biochemical timing of peri-intraventricular hemorrhage assessed by perinatal CPK-BB isoenzyme measurements.
abstract: Precise diagnosis of peri-intraventricular hemorrhage (PIVH) requires brain real-time ultrasound imaging procedure (US). However, maximal diagnostic efficiency of US lies between day 4 and 14 since fresh blood may initially appear sonolucent. Because of this supposed interval required for clot formation to become visible on US, serum CPK-BB estimations were performed in the first 60 hours of life to determine precise biochemical timing of PIVH. A group of 50 preterm infants less than 1500 g birth weight (1120 +/- 320 g) and 34 weeks gestation (30 +/- 3.7 weeks) was studied. Serial CPK-BB measurements were performed in serum immediately after birth (T0), then serially at time T1 (6-10 h), T2 (20-30 h), T3 (40-60 h). The incidence of PIVH diagnosed on the third day of life was 30%. Total CPK-BB values at T0 in infants who developed PIVH were significantly higher than those of patients without cerebral bleeding (70.8 +/- 30.5 vs 20.9 +/- 10.7 U/l) (p less than 0.05). The same statistically significant results were not observed analysing the CPK-BB values at T1, T2 and T3. These results suggest that most pathological conditions responsible for enzyme release occur in the pre- or perinatal period.
authors.affiliation: Department of Obstetrics and Gynecology, University of Berne, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Amato
authors.forename: P
authors.initials: P
authors.lastname: Hüppi
authors.forename: R
authors.initials: R
authors.lastname: Gambon
authors.forename: H
authors.initials: H
authors.lastname: Schneider
mesh_terms: D001921:Brain / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000175:diagnosis*; D003402:Creatine Kinase; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007527:Isoenzymes; D008297:Male; D014463:Ultrasonography; D006475:Vitamin K Deficiency Bleeding / Q000175:diagnosis*
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase