Renal oncocytoma. A phenotypic and genotypic entity of renal parenchymal tumors.
The light and electron microscopic morphology of two renal parenchymal tumors was consistent with the diagnosis of renal oncocytoma. Both tumors had a mosaic chromosome pattern of cells with normal and abnormal karyotypes. No recurrent chromosome aberration and also no rearrangement of chromosome 3p was found. Restriction analysis of the mitochondrial DNA revealed a new autoradiographic band at about 50 basepairs in size occurring exclusively in oncocytomas. The possible use of these findings in the diagnosis of renal oncocytomas is discussed.
Kovacs
G
G
Institute of Pathology, Hannover Medical School, Federal Republic of Germany.
Welter
C
C
Wilkens
L
L
Blin
N
N
Deriese
W
W
D000236:Adenoma / Q000235:genetics* / Q000648:ultrastructure; D000368:Aged; D002869:Chromosome Aberrations; D002890:Chromosomes, Human, Pair 20; D002893:Chromosomes, Human, Pair 3; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics* / Q000648:ultrastructure; D008875:Middle Aged; D015183:Restriction Mapping
D004273:DNA, Neoplasm