[Central serotonin administration and post-stress damage of the gastric mucosa in inbred mice during various seasons].
The severity of neurogenic damage to the gastric mucosa (GM) induced by emotional stress (ES) in administration of serotonin or its precursor in biosynthesis--5-hydroxytryptophan into the lateral ventricle of the brain was studied in experiments on mice of inbred strains. The development of lesions in the GM in the form of erosions and hemorrhages proved to be dependent on many factors, first of all on the time of administration of the preparations--before or after ES. The effect of 5-hydroxytryptophan on the formation of GM stress damage was less marked than that of serotonin. The intensifying effect of exogenous serotonin on post-stress GM damage was mainly manifested in the spring, which is associated with ES induced activation of the brain serotonergic system. The effect of exogenous serotonin on the degree of the neurogenous damage to the GM caused by ES is determined to a great measure by the genotype differences in the sensitivity of the central serotonergic mechanisms to the stimulating effect.
Koriakina
L A
LA
Serova
L I
LI
D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012621:Seasons; D012701:Serotonin / Q000494:pharmacology*; D013315:Stress, Psychological / Q000473:pathology*
D012701:Serotonin
Tsentral'noe vvedenie serotonina i poststressornye povrezhdeniia slizistoĭ obolochki zheludka mysheĭ inbrednykh liniĭ v raznye sezony.