[Spermatozoal antibodies in cervical mucus and in the luminal fluid of the uterus in sterile patients].
Poor postcoital tests in infertile patients may be due to dysmucurrhoea, low sperm count, or specific antibodies against spermatozoa. Using a latex agglutination test ("Sperm-antibody-slide-test", Fa. Biotec, Hannover), we examined the cervical and uterine secretions of the patients for sperm antibodies. The results showed a close correlation between a positive sperm-antibody-test and a poor postcoital test, especially in those couples with regular sperm quality. Also in cases with normal postcoital tests, positive sperm-antibody titers can be observed. Therefore, the sperm-antibodies may disturb fertilization in infertile patients even without causing immobilization or agglutination of the spermatozoa in the female genital tract fluids. The determination of the spermatozoa-antibody content in the cervical and uterine secretions must be regarded as an improvement in the diagnostic procedure in human infertility.
Maas
D H
DH
Frauenklinik der Medizinischen Hochschule Hannover.
Timm
G
G
Mesrogli
M
M
Degenhardt
F
F
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D000918:Antibody Specificity; D002582:Cervix Mucus / Q000276:immunology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000276:immunology*; D007841:Latex Fixation Tests; D008297:Male; D008875:Middle Aged; D013094:Spermatozoa / Q000276:immunology*; D014599:Uterus / Q000276:immunology*
D000906:Antibodies
Spermatozoen-Antikörper im zervikalen Mukus und in der luminalen Flüssigkeit des Uterus bei Sterilitätspatientinnen.