title: Circulating levels of placental protein 12 and chorionic gonadotrophin following RU 38486 and gemeprost for termination of first trimester pregnancy.
abstract: First trimester termination of pregnancy was successfully induced in ten patients with RU 38486 followed 2 days later by a prostaglandin (Gemeprost) pessary. Human chorionic gonadotrophin (HCG) values remained unaltered until after the abortion. The levels of placental protein 12 (PP12) showed an immediate and significant fall following RU 38486, then rose to values substantially higher than those at the initial visit after 2 days. These findings show that RU 38486 has a direct inhibitory effect on tissues producing PP12 and confirm the progesterone dependency of this protein.
authors.affiliation: Department of Obstetrics and Gynaecology, St Bartholomew's Hospital Medical College, London, UK.
authors.forename: F
authors.initials: F
authors.lastname: Olajide
authors.forename: R J
authors.initials: RJ
authors.lastname: Howell
authors.forename: J A
authors.initials: JA
authors.lastname: Wass
authors.forename: J M
authors.initials: JM
authors.lastname: Holly
authors.forename: H
authors.initials: H
authors.lastname: Bohn
authors.forename: J G
authors.initials: JG
authors.lastname: Grudzinskas
authors.forename: M G
authors.initials: MG
authors.lastname: Chapman
authors.forename: T
authors.initials: T
authors.lastname: Chard
mesh_terms: D000019:Abortifacient Agents / Q000494:pharmacology*; D000020:Abortifacient Agents, Nonsteroidal / Q000494:pharmacology*; D000021:Abortifacient Agents, Steroidal / Q000494:pharmacology*; D000028:Abortion, Induced; D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology; D002352:Carrier Proteins / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000097:blood*; D004963:Estrenes / Q000494:pharmacology*; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1; D018969:Insulin-Like Growth Factor Binding Proteins; D015735:Mifepristone; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*
chemical_list: D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D002352:Carrier Proteins; D006063:Chorionic Gonadotropin; D004963:Estrenes; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D018969:Insulin-Like Growth Factor Binding Proteins; D011257:Pregnancy Proteins; D015735:Mifepristone; C021182:gemeprost; D000527:Alprostadil