title: The Scottish first episode schizophrenia study. VII. Two-year follow-up. Scottish Schizophrenia Research Group.
abstract: Of 49 schizophrenic patients followed up 2 years after their first admission to hospital, 37% were well, 47% had been readmitted to hospital at some time over the 2 years, and 38% showed schizophrenic symptoms at follow-up. A poor outcome at 2 years was associated with male sex, poor outcome after the first 5 weeks of the first admission, negative schizophrenic symptoms on first admission, and a diagnosis of definite or probable schizophrenia using the Feighner criteria. Only 23% were in employment. A small double-blind discontinuation study of maintenance antipsychotic medication during the second year found more relapses in those switched to placebo medication. Repeat psychometric assessment at 2 years confirmed modest improvements found at 12 months; that is, there was no evidence of intellectual decline. Relatives showed no more psychosocial distress than that found in a normal community sample; what distress there was correlated with patients' schizophrenic symptoms.
authors.affiliation: Crichton Royal Hospital, Dumfries, United Kingdom.
authors.forename: R G
authors.initials: RG
authors.lastname: McCreadie
authors.forename: D
authors.initials: D
authors.lastname: Wiles
authors.forename: S
authors.initials: S
authors.lastname: Grant
authors.forename: G T
authors.initials: GT
authors.lastname: Crockett
authors.forename: Z
authors.initials: Z
authors.lastname: Mahmood
authors.forename: M G
authors.initials: MG
authors.lastname: Livingston
authors.forename: J A
authors.initials: JA
authors.lastname: Watt
authors.forename: J G
authors.initials: JG
authors.lastname: Greene
authors.forename: P W
authors.initials: PW
authors.lastname: Kershaw
authors.forename: N A
authors.initials: NA
authors.lastname: Todd
mesh_terms: D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005190:Family; D005475:Flupenthixol / Q000031:analogs & derivatives / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D010868:Pimozide / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D012008:Recurrence; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D012606:Scotland; D012917:Social Adjustment; D013892:Thioxanthenes / Q000627:therapeutic use*
chemical_list: D013892:Thioxanthenes; D010868:Pimozide; C007761:flupenthixol decanoate; D005475:Flupenthixol