[Determination of tumor-associated trypsin inhibitor (TATI) in subjects with gastrointestinal diseases. Preliminary data].
Tumor-associated trypsin inhibitor (TATI) is a 6 K dalton protease inhibitor, that was isolated from urine of a patient with ovarian cancer. In our experience, mean serum level of TATI in healthy subjects (n. 120), is 13 micrograms/l (range 5.1-42 micrograms/l). The cut-off point is established in 32 micrograms/l (mean +/- 3 SD). We have examined 357 patients with gastrointestinal diseases: 98 gastric cancer, 50 colon cancers, 52 pancreatic cancers, 32 chronic pancreatitis, 38 IBD, 28 colon polyps, 40 gastric ulcers and 25 non-neoplastic biliary tree diseases. TATI may be a good tumor marker only in gastric cancer. Elevated levels of TATI also occur in obstructive hepatobiliary disease and active pancreatitis or IBD.
Piantino
P
P
Divisione di Gastroenterologia, Ospedale Maggiore San Giovanni Battista Molinette, Torino.
Mosso
R
R
Polloni
R
R
Cerchier
A
A
Gennaretti
G
G
Daziano
E
E
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D014408:Biomarkers, Tumor / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005260:Female; D005767:Gastrointestinal Diseases / Q000097:blood*; D005770:Gastrointestinal Neoplasms / Q000097:blood; D006801:Humans; D008297:Male; D011863:Radioimmunoassay / Q000295:instrumentation; D011933:Reagent Kits, Diagnostic; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000097:blood*; D014361:Trypsin Inhibitors / Q000097:blood*
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D011933:Reagent Kits, Diagnostic; D014361:Trypsin Inhibitors; D014359:Trypsin Inhibitor, Kazal Pancreatic
Dosaggio del tumor associated trypsin inhibitor (TATI) in soggetti con malattie gastrointestinali. Dati preliminari.