Impairment after adult respiratory distress syndrome. An evaluation based on American Thoracic Society recommendations.
To test the hypothesis that impairment after the adult respiratory distress syndrome (ARDS) is uncommon, we evaluated 41 ARDS survivors using ATS standards for determination of impairment. A total of 101 trials of pulmonary function tests were obtained between 1 and 388 wk after the onset of ARDS. It was possible to evaluate impairment at 1 yr or more after ARDS in 27 subjects. Eighteen of the 27 were impaired. The percentage of ARDS survivors who were impaired on the basis of FVC, FEV1, FEV1/FVC, and DLCOsb was 50.0, 61.1, 33.3, and 82.4%, respectively. Impairment was mild in 13 (72.2%), moderate in four (22.2%), and severe in one (5.6%). Smoking status had no predictive value in determining impairment. Physiologic indices of ARDS severity (maximal pulmonary artery pressure, lowest static thoracic compliance, and maximal level of PEEP) were found to be significantly different when those impaired 1 yr or more after ARDS were compared with those not impaired. Symptoms were found to have no association with impairment. We conclude that, using ATS criteria, impairment 1 yr or more after ARDS onset is common. Patient characteristics and symptoms after ARDS have no association with impairment 1 yr or more after ARDS onset, whereas physiologic indices of severity during ARDS do.
Ghio
A J
AJ
Department of Internal Medicine, LDS Hospital, Salt Lake City, UT 84143.
Elliott
C G
CG
Crapo
R O
RO
Berlin
S L
SL
Jensen
R L
RL
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015272:Pulmonary Medicine; D012128:Respiratory Distress Syndrome / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012955:Societies, Medical; D013997:Time Factors; D014481:United States