The effect of sex hormones and tamoxifen on the growth of human gastric and colorectal cancer cell lines.
The authors studied the effect of serial concentrations of estradiol, 4-hydroxytamoxifen with estradiol, and 5-dihydrotestosterone on cell lines derived from human gastric and colorectal cancers. Significant stimulation of the gastric and 2 colorectal cell lines occurred at physiologic concentrations of estradiol. Addition of the active metabolite of the estrogen-receptor blocker/partial-agonist 4-hydroxytamoxifen had a stimulating effect on the growth rate of the gastric cell lines. The androgen, 5-dihydrotestosterone, had a modest inhibitory effect on the two gastric cell lines and two of the colorectal cell lines, and a stimulating effect on two further cell lines.
Harrison
J D
JD
Department of Surgery, Queen's Medical Centre, Nottingham, England.
Watson
S
S
Morris
D L
DL
D002460:Cell Line; D002784:Cholesterol / Q000494:pharmacology; D015179:Colorectal Neoplasms / Q000473:pathology*; D013196:Dihydrotestosterone / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006801:Humans; D013274:Stomach Neoplasms / Q000473:pathology*; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology
D012739:Gonadal Steroid Hormones; D013196:Dihydrotestosterone; D013629:Tamoxifen; C016601:afimoxifene; D004958:Estradiol; D002784:Cholesterol