Suppression of resistance to Salmonella typhimurium in young chickens inoculated with Corynebacterium parvum.
The effect of Corynebacterium parvum on resistance to Salmonella typhimurium infection was evaluated in young chickens. One-day-old chickens were inoculated subcutaneously (SC) or intraperitoneally (IP) with 1.4 mg killed C. parvum and challenged by IP injection with 5.0 X 10(7) S. typhimurium 4 days later. Spleen and bursa of Fabricius weights were not altered in the C. parvum-inoculated chickens. A transient increase in thymus weight occurred 3 days after inoculation with C. parvum. Phytohemagglutinin-elicited cutaneous hypersensitivity was significantly suppressed in the C. parvum-inoculated chickens. Morbidity due to Salmonella infection increased significantly from 15% and 21% in the control groups to 43% and 46% in the chickens inoculated IP or SC with C. parvum. The results indicated that inoculation of 1-day-old chickens with C. parvum suppressed cell-mediated immune responsiveness and decreased resistance to peritoneal infection with S. typhimurium.
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U.S. Department of Agriculture, Veterinary Toxicology and Entomology Research Laboratory, College Station, Texas 77840.
Ziprin
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D000818:Animals; D002645:Chickens / Q000276:immunology*; D007108:Immune Tolerance; D008297:Male; D009929:Organ Size; D011425:Propionibacterium acnes / Q000276:immunology; D012481:Salmonella Infections, Animal / Q000276:immunology*; D012486:Salmonella typhimurium / Q000276:immunology*