Osteopenia in inhabitants with renal dysfunction induced by exposure to environmental cadmium.
Bone density was measured in 28 women with itai-itai disease, 92 men and 114 women with cadmium-induced renal dysfunctions and 44 men and 66 women living in the three different non-polluted areas using a microdensitometer. The values of both indices corresponding to cortical width and bone mineral content were significantly lower in itai-itai disease patients than the cadmium-exposed women with renal dysfunctions and the non-exposed subjects. The cadmium-exposed women also showed a decrease in bone density compared with the non-exposed subjects. A significant decrease in bone density was also observed between cadmium-exposed men and the non-exposed subjects, although the difference was not as clear as in the women. The present study indicates that exposure to cadmium could cause marked osteopenia, particularly in the women.
Kido
T
T
Department of Hygiene, Kanazawa Medical University, Ishikawa, Japan.
Nogawa
K
K
Yamada
Y
Y
Honda
R
R
Tsuritani
I
I
Ishizaki
M
M
Yamaya
H
H
D000368:Aged; D001851:Bone Diseases, Metabolic / Q000139:chemically induced* / Q000473:pathology; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology; D002104:Cadmium / Q000009:adverse effects; D002105:Cadmium Poisoning / Q000150:complications* / Q000473:pathology; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007564:Japan; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D012737:Sex Factors
D002104:Cadmium