title: The combined effect of cisplatin and furosemide on hearing function in guinea pigs.
abstract: The effect of the combined administration of cisplatin and furosemide on the electrophysiological hearing thresholds and endocochlear DC potential (EP) was studied in guinea pigs. A lack of interaction was found in animals given repeated intraperitoneal injections of a low dose of cisplatin with a pharmacological dose of furosemide. An ototoxic interaction occurred when a moderately high dose of cisplatin was administered intravenously at a time when the strial function was most affected by a very high dose of furosemide. The interaction was seen both as a decreased EP and a pronounced shift of auditory thresholds. It is concluded that the stria vascularis plays a role in the ototoxic mechanism of cisplatin.
authors.affiliation: Institute of Physiology II, Karolinska Institute, Stockholm, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Laurell
authors.forename: B
authors.initials: B
authors.lastname: Engström
mesh_terms: D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects*; D001933:Brain Stem / Q000187:drug effects; D002945:Cisplatin / Q000633:toxicity*; D003055:Cochlear Microphonic Potentials / Q000187:drug effects; D003056:Cochlear Nerve / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005665:Furosemide / Q000633:toxicity*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects; D013316:Stria Vascularis / Q000187:drug effects
chemical_list: D005665:Furosemide; D002945:Cisplatin