[The action of inhibitors of sugar transport phlorizin, phloretin and cytochalasin B in model systems].
Phlorizin, phloretin and cytochalasin B are known to be specific sugar transport inhibitors. A study was made of their effects on the carbohydrate-protein interaction in solution as a model system for examining the initial steps of sugar membrane transport. Glycogen precipitation by concanavalin A is inhibited only by alpha-methylmannoside, whereas both phlorizin and phloretin inhibit interactions between hexokinase and glucose, and between glucose-6-phosphate dehydrogenase and glucose-6-phosphate. Cytochalasin B was found to exert no effect on both the concanavalin A--glycogen interaction and the enzyme reactions investigated. The data obtained in the model system examination may suggest that the sites of glucose and cytochalasin binding are, respectively, spatially uncoupled.
Vasianin
S I
SI
D001692:Biological Transport / Q000187:drug effects; D050260:Carbohydrate Metabolism; D003208:Concanavalin A / Q000378:metabolism; D003571:Cytochalasin B / Q000494:pharmacology*; D003864:Depression, Chemical; D004347:Drug Interactions; D006003:Glycogen / Q000378:metabolism; D066298:In Vitro Techniques; D008027:Light; D008954:Models, Biological; D010693:Phloretin / Q000494:pharmacology*; D010695:Phlorhizin / Q000494:pharmacology*; D012542:Scattering, Radiation; D012996:Solutions
D012996:Solutions; D003208:Concanavalin A; D003571:Cytochalasin B; D006003:Glycogen; D010695:Phlorhizin; D010693:Phloretin
Issledovanie deĭstviia ingibitorov transporta sakharov floritsina, floretina i tsitokhalazina B v model'nykh sistemakh.