Estimate of anti-Plasmodium falciparum sporozoite activity in humans vaccinated with synthetic circumsporozoite protein (NANP)3.
A mathematical model was defined to estimate the degree of in vivo activity against Plasmodium falciparum sporozoites expressed by volunteers vaccinated with a synthetic peptide comprising the immunodominant epitope of the circumsporozoite protein. Relative to the course of infection in non-immunized controls, infections in vaccinated volunteers corresponded to the neutralization or delay of development of greater than 99% of challenge sporozoites.
Davis
J R
JR
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201.
Murphy
J R
JR
Baqar
S
S
Clyde
D F
DF
Herrington
D A
DA
Levine
M M
MM
D000818:Animals; D006801:Humans; D008288:Malaria / Q000517:prevention & control*; D008962:Models, Theoretical; D009842:Oligopeptides / Q000008:administration & dosage*; D010963:Plasmodium falciparum / Q000254:growth & development* / Q000276:immunology; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000627:therapeutic use
D009842:Oligopeptides; D014614:Vaccines, Synthetic; C052953:(asparaginyl-alanyl-asparaginyl-proline)3