title: Effect of indomethacin and prednisolone on the disruption of the blood-aqueous barrier after hyperthermia on the rabbit eye by focused ultrasound.
abstract: In 24 rabbits both eyes were treated in the perilimbic area with hyperthermia by focussed ultrasound at a frequency of 4.65 MHz. The intra-ocular pressure (IOP) decreased significantly in all eyes. The effect of pre-treatment with indomethacin and prednisolone on the inflammatory response induced by the insonification was assessed by determination of protein in the aqueous humour 2 h after ultrasound treatment. Local pre-treatment with indomethacin but not with prednisolone was followed by less increase in protein concentration of the aqueous humour as compared to placebo-treated controls. The IOP was not influenced significantly by the drug pre-treatments.
authors.affiliation: Department of Ophthalmology, University Medical Centre, Leiden, The Netherlands.
authors.forename: C L
authors.initials: CL
authors.lastname: van Hees
authors.forename: J L
authors.initials: JL
authors.lastname: van Delft
authors.forename: C C
authors.initials: CC
authors.lastname: Sterk
authors.forename: N J
authors.initials: NJ
authors.lastname: van Haeringen
authors.forename: J A
authors.initials: JA
authors.lastname: Oosterhuis
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects / Q000378:metabolism*; D001769:Blood / Q000378:metabolism*; D005123:Eye / Q000098:blood supply / Q000187:drug effects; D006979:Hyperthermia, Induced; D007213:Indomethacin / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects; D011239:Prednisolone / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D011817:Rabbits; D014465:Ultrasonics
chemical_list: D011506:Proteins; D011239:Prednisolone; D007213:Indomethacin