Atypical scleroderma associated with multiple myeloma.
A case of atypical scleroderma associated with multiple myeloma is reported. The patient was a 50-year-old male; morphea-like plaques with brownish pigmentation were scattered on the whole body and sclerodactylia-like changes, contracture of fingers and polymyositis were observed. Histological findings in the sclerotic lesions were consistent with scleroderma. One year later, M-protein (IgG, kappa-chain) appeared in the serum and 3 years from the onset, the patient was diagnosed as multiple myeloma by bone marrow examination. It is speculated that abnormal immunological reactions related to multiple myeloma caused scleroderma-like lesions.
Nakanishi
H
H
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
Takehara
K
K
Soma
Y
Y
Ishibashi
Y
Y
D003094:Collagen; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000473:pathology*; D010859:Pigmentation Disorders / Q000473:pathology; D012594:Scleroderma, Localized / Q000150:complications / Q000473:pathology*; D012867:Skin / Q000473:pathology
D003094:Collagen