title: Double-blind placebo-controlled study of milnacipran in hospitalized patients with major depressive disorders.
abstract: Fifty-eight inpatients with a DSM-III diagnosis of major depressive disorder participated in a 5-week double-blind trial of milnacipran and placebo. Milnacipran was superior to placebo on all measures of depression. The first index of milnacipran superiority was the difference of dropouts due to treatment failure between milnacipran (10.3%) and placebo (55.2%). All patients were evaluated up to day 14. The improvement with milnacipran was statistically significant at day 14. Side effects were identical for milnacipran and placebo.
authors.affiliation: Department of Psychiatry, University of Liège, Belgium.
authors.forename: J P
authors.initials: JP
authors.lastname: Macher
authors.forename: J P
authors.initials: JP
authors.lastname: Sichel
authors.forename: C
authors.initials: C
authors.lastname: Serre
authors.forename: R
authors.initials: R
authors.lastname: Von Frenckell
authors.forename: J C
authors.initials: JC
authors.lastname: Huck
authors.forename: J P
authors.initials: JP
authors.lastname: Demarez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents; D003521:Cyclopropanes / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000078764:Milnacipran; D010556:Personality Tests; D016032:Randomized Controlled Trials as Topic; D016037:Single-Blind Method
chemical_list: D000928:Antidepressive Agents; D003521:Cyclopropanes; D000078764:Milnacipran