title: Uveal melanoma radiation. 125I brachytherapy versus helium ion irradiation.
abstract: The optimum radiation therapy for uveal melanoma is uncertain. Both helium ion irradiation and 125I brachytherapy have been used to treat this neoplasm. This investigation analyzed the control and complication rates of uveal melanomas treated with helium ions of 125I plaques. In both a retrospective and a prospective dynamically balanced study, the control rates appeared to be similar. There were more posterior segment complications after 125I plaques and more anterior segment complications, including neovascular glaucoma, after helium ion irradiation. The follow-up period is too short to draw definitive conclusions on the radiation complications. Overall, approximately 89% of eyes were retained and less than 4% of treated eyes were removed because of failure to control the tumor.
authors.affiliation: Department of Ophthalmology, University of California, San Francisco 94143.
authors.forename: D H
authors.initials: DH
authors.lastname: Char
authors.forename: J R
authors.initials: JR
authors.lastname: Castro
authors.forename: J M
authors.initials: JM
authors.lastname: Quivey
authors.forename: T L
authors.initials: TL
authors.lastname: Phillips
authors.forename: A R
authors.initials: AR
authors.lastname: Irvine
authors.forename: R D
authors.initials: RD
authors.lastname: Stone
authors.forename: S
authors.initials: S
authors.lastname: Kroll
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects; D005500:Follow-Up Studies; D006371:Helium / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D008545:Melanoma / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary; D008875:Middle Aged; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D016019:Survival Analysis; D014604:Uveal Neoplasms / Q000401:mortality / Q000532:radiotherapy*
chemical_list: D007457:Iodine Radioisotopes; D006371:Helium