[Modifying effect of oxolinic acid on the radiation-induced hemorrhagic syndrome].
The radioprotective effect of oxolinic acid (200 mg/kg) was studied in irradiated guinea pigs (3 Gy, 0.83 cGy/min) by the following criteria: survival rate, hemorrhage severity, and homeostasis disturbance. Oxolinic acid was found to decrease the death rate, severity of hemorrhage and the degree of thrombo- and leukopenia, and to reduce the injury to blood coagulation and vascular wall of irradiated animals.
Tartakovskiĭ
V N
VN
Pukhov
V V
VV
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects / Q000528:radiation effects; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006470:Hemorrhage / Q000097:blood / Q000401:mortality / Q000517:prevention & control*; D051379:Mice; D010093:Oxolinic Acid / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000401:mortality / Q000517:prevention & control*; D011837:Radiation-Protective Agents; D013577:Syndrome; D013997:Time Factors
D011837:Radiation-Protective Agents; D010093:Oxolinic Acid
Modifitsiruiushchee vliianie oksolinovoĭ kisloty na luchevoĭ gemorragicheskiĭ sindrom.