Localization and structure of the muscarinic receptor ligand binding site.
A conserved aspartic acid residue in transmembrane helix 3 of the muscarinic acetylcholine receptors is important in binding the headgroup of muscarinic ligands. This acidic amino acid probably points into a relatively hydrophilic cavity whose walls are formed by the amphipathic transmembrane helices of the receptor. Amino acid side chains within this cavity contribute to ligand binding.
Hulme
E C
EC
Curtis
C A
CA
Wheatley
M
M
Aitken
A
A
Harris
A C
AC
D001665:Binding Sites; D006801:Humans; D008024:Ligands; D011976:Receptors, Muscarinic / Q000032:analysis* / Q000235:genetics
D008024:Ligands; D011976:Receptors, Muscarinic