Molecular basis of complement deficiencies.
Genetically determined human complement deficiencies and genetic deficiencies of the corresponding proteins in other species have been recognized for many years. In the past decade, molecular cloning methods have been utilized to deduce the complete primary structure of most of the complement proteins, determine the structure and chromosomal localization of many complement genes, and to define the basis for complement genetic variants including null alleles.
Perlmutter
D H
DH
Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110.
Colten
H R
HR
D002874:Chromosome Mapping; D003165:Complement System Proteins / Q000172:deficiency* / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex; D011951:Receptors, Complement / Q000172:deficiency / Q000235:genetics
D011951:Receptors, Complement; D003165:Complement System Proteins