title: Gingival fluid, beta 2-microglobulin and protein levels as indicators of periodontal disease.
abstract: beta 2-microglobulin (beta 2-m), lysozyme and protein concentrations in gingival fluid were analyzed in 19 patients with severe periodontitis and in 19 controls devoid of any clinical signs of inflammation. A significant increase of the total protein and beta 2-m levels was found in periodontal subjects. In contrast, lysozyme concentration did not reflect the inflammatory status of the periodontium. Statistical analyses showed significant correlations between beta 2-m and protein concentrations in both groups. Furthermore, the values obtained by Periotron 600 closely correlated with the protein and beta 2-m contents, indicating that this method is a reliable aid in assessment of the quantity and quality of crevicular exudate and thus the severity of periodontal disease.
authors.affiliation: Faculty of Dentistry, University of Kuopio, Finland.
authors.forename: S M
authors.initials: SM
authors.lastname: Syrjänen
authors.forename: P
authors.initials: P
authors.lastname: Alakuijala
authors.forename: S O
authors.initials: SO
authors.lastname: Markkanen
authors.forename: H
authors.initials: H
authors.lastname: Markkanen
mesh_terms: D000328:Adult; D003945:Diagnosis, Oral / Q000295:instrumentation; D005883:Gingival Crevicular Fluid / Q000201:enzymology / Q000276:immunology*; D005891:Gingivitis / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D009113:Muramidase / Q000032:analysis; D010518:Periodontitis / Q000201:enzymology / Q000276:immunology*; D011506:Proteins / Q000032:analysis; D001613:beta 2-Microglobulin / Q000032:analysis*
chemical_list: D011506:Proteins; D001613:beta 2-Microglobulin; D009113:Muramidase