title: Penetration of monobactam antibiotics (aztreonam, carumonam) into human prostatic tissue.
abstract: Concomitant concentrations of monobactam antibiotics were measured in plasma and in prostatic tissue obtained by transurethral resection in 25 patients, 60-120 min after dosage. A 1-gram single intravenous injection of aztreonam or carumonam yielded mean prostatic concentrations of 6.0 mg/kg in 20 patients. Five patients who received a 2-gram dose of carumonam demonstrated average prostatic levels of 10 mg/kg. These concentrations significantly exceed MIC values for most common gram-negative urinary tract pathogens.
authors.affiliation: Department of Infectious Diseases, Princess Alexandra Hospital, Brisbane, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Whitby
authors.forename: J
authors.initials: J
authors.lastname: Hempenstall
authors.forename: C
authors.initials: C
authors.lastname: Gilpin
authors.forename: L
authors.initials: L
authors.lastname: Weir
authors.forename: G
authors.initials: G
authors.lastname: Nimmo
mesh_terms: D000368:Aged; D001398:Aztreonam / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011467:Prostate / Q000378:metabolism*
chemical_list: C044145:carumonam; D001398:Aztreonam