Peripheral nerve injury causes transient expression of MHC class I antigens in rat motor neurons and skeletal muscles.
After a peripheral nerve lesion (rat facial and sciatic) an induction of major histocompatibility complex (MHC) antigens class I was detected immunohistochemically in skeletal muscle fibers and motor neurons. This MHC expression was transient after a nerve crush, when regeneration occurred, but persisted after a nerve cut, when regeneration was prevented. Since the time course of MHC class I expression correlates to that of regeneration a role for this cell surface molecule in regeneration may be considered.
Maehlen
J
J
Department of Pathology and Neurology, Karolinska Institutet, Huddinge, Sweden.
Nennesmo
I
I
Olsson
A B
AB
Olsson
T
T
Schröder
H D
HD
Kristensson
K
K
D000818:Animals; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D008297:Male; D009046:Motor Neurons / Q000276:immunology* / Q000502:physiology; D009132:Muscles / Q000276:immunology* / Q000502:physiology; D009416:Nerve Regeneration; D059348:Peripheral Nerve Injuries; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D015395:Histocompatibility Antigens Class I