title: Detection of reactive free radicals in fresh coal mine dust and their implication for pulmonary injury.
abstract: Freshly ground and aged anthracite and bituminous coal samples were investigated by electron spin resonance (ESR) spectroscopy to detect the presence, concentration and reactivity of free radicals. Freshly ground anthracite coal produced greater concentration of free radicals than the bituminous coal, and the radical reactivity was also greater for the anthracite. The reactivity of the newly produced free radicals in the anthracite dust correlated with the dust's toxicity. Furthermore, similar coal-based free radicals were detected in the lung tissue of autopsied coal miners, suggestive of persistent reactivity by the embedded coal dust leading to the progressive disease process. Results of the studies on the severity of coal workers' pneumoconiosis (CWP) and free radical concentration in lung tissue support this hypothesis.
authors.forename: N S
authors.initials: NS
authors.lastname: Dalal
authors.forename: M M
authors.initials: MM
authors.lastname: Suryan
authors.forename: V
authors.initials: V
authors.lastname: Vallyathan
authors.forename: F H
authors.initials: FH
authors.lastname: Green
authors.forename: B
authors.initials: B
authors.lastname: Jafari
authors.forename: R
authors.initials: R
authors.lastname: Wheeler
mesh_terms: D003031:Coal / Q000009:adverse effects / Q000032:analysis*; D003032:Coal Mining; D004391:Dust / Q000009:adverse effects / Q000032:analysis*; D005609:Free Radicals; D006801:Humans; D008168:Lung / Q000032:analysis*; D011009:Pneumoconiosis / Q000209:etiology*
chemical_list: D003031:Coal; D004391:Dust; D005609:Free Radicals