Haemopoietic growth factor control of normal and neoplastic cellular proliferation.
Endotoxin induces the appearance of granulocyte colony stimulating factor (G-CSF) and macrophage (M)-CSF in the serum of mice. No GM-CSF was detectable in endotoxin serum. Phytohaemagglutinin stimulated human T-lymphocytes to secrete three major forms of GM-CSF. All of the haemopoietic growth factors (HGFs) are active in vivo, but the cellular responses are different for each HGF. Prolonged administration of G-CSF increases the number of circulating neutrophils and does not lead to adverse side-effects. Chronic exposure to GM-CSF induces an accumulation of activated macrophages which can cause considerable tissue destruction. Although the 'src-like' oncogenes induce HGF production by chicken myeloblasts, factor-dependent murine cells can be converted to a tumorigenic phenotype without autocrine growth factor production.
Burgess
A W
AW
Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia.
Cebon
J
J
Smith
S
S
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology*; D006410:Hematopoiesis; D016298:Hematopoietic Cell Growth Factors; D006412:Hematopoietic Stem Cells / Q000502:physiology; D007938:Leukemia / Q000209:etiology; D051379:Mice; D008938:Mitosis; D013601:T-Lymphocytes / Q000378:metabolism
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016298:Hematopoietic Cell Growth Factors