Furnace-generated acid aerosols: speciation and pulmonary effects.
Guinea pigs were exposed to ultrafine aerosols (less than 0.1 micron) of zinc oxide with a surface layer of sulfuric acid. These acid-coated aerosols are typical of primary emissions from smelters and coal combustors. Repeated daily 3-hr exposures for 5 days produce decrements in lung volumes and pulmonary diffusing capacity and elevations of lung weight/body weight ratio, protein, and number of neutrophils in pulmonary lavage fluid at concentrations of 20 micrograms/m3. A single 1-hr exposure to 20 micrograms/m3 causes increased bronchial reactivity. Higher concentrations of conventionally generated sulfuric acid mist are required to produce responses of similar magnitude.
Amdur
M O
MO
Department of Applied Biological Science, Massachusetts Institute of Technology, Cambridge 02139.
Chen
L C
LC
D015258:Acid Rain / Q000633:toxicity*; D000336:Aerosols; D000393:Air Pollutants / Q000633:toxicity*; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D003031:Coal / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006361:Heating; D008176:Lung Volume Measurements; D010316:Particle Size; D011650:Pulmonary Alveoli / Q000187:drug effects*; D013458:Sulfur Dioxide / Q000633:toxicity; D013464:Sulfuric Acids / Q000633:toxicity*; D015034:Zinc Oxide / Q000633:toxicity
D015258:Acid Rain; D000336:Aerosols; D000393:Air Pollutants; D003031:Coal; D013464:Sulfuric Acids; D013458:Sulfur Dioxide; C033158:sulfuric acid; D015034:Zinc Oxide