Transmembrane signalling at the epidermal growth factor receptor.
The EGF receptor, which is homologous to the v-erb-B oncogene product, has intrinsic tyrosine kinase activity, and mediates an increase in polyphosphoinositide turnover and [Ca2+]i. Recently, great progress has been made in understanding the mechanism of signal transduction at this receptor. Jacopo Meldolesi and colleagues discuss how this knowledge may lead to a better understanding of the control of cell proliferation.
Pandiella
A
A
Beguinot
L
L
Vicentini
L M
LM
Meldolesi
J
J
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology; D066246:ErbB Receptors / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction
D066246:ErbB Receptors