Three actin-binding proteins are developmentally regulated in rat liver plasma membranes.
Actin-binding membrane proteins (linking microfilaments to the cell membrane) are involved in cytoskeleton-membrane interactions which are supposed to undergo profound changes during cell proliferation and development. In this study 8 polypeptides were shown to bind F-actin directly in the liver cell membranes of mature rats. From these, the abundance of three polypeptides, of 130, 50 and 36 kDa, was observed to increase considerably during postnatal development, which indicates a developmental change in the cytoskeleton-membrane interactions.
Keresztes
M
M
Institute of Biochemistry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
D000818:Animals; D000831:Animals, Newborn; D002462:Cell Membrane / Q000378:metabolism*; D002846:Chromatography, Affinity; D003599:Cytoskeleton / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D008099:Liver / Q000254:growth & development / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D008840:Microfilament Proteins / Q000378:metabolism* / Q000502:physiology; D010455:Peptides / Q000032:analysis; D051381:Rats
D008565:Membrane Proteins; D008840:Microfilament Proteins; D010455:Peptides