title: Quantification and kinetics of purine catabolism in Dalmatian dogs at low and high purine intakes.
abstract: 1. In eight Dalmatian dogs low and high purine intakes resulted in plasma urate levels from 25 to 185 mumol/l. 2. The relationship between purine intake and excretion of uric acid and allantoin per day was described by linear regression equations. 3. The elimination of endogenous purines was 1.8 mmol/day for urate and 1.7 mmol/day for allantoin. Exogenous purines increased renal excretion by 0.57 mmol/mmol. 4. Kinetic measurements with [2(-14)C]uric acid infused continuously into each of two dogs on low and high purine revealed increases of plasma pool (urate + allantoin) of 3.3 fold and entry rate of 4.0 fold. Conversion of urate into allantoin increased from 20 to 36%. 5. Renal elimination of catabolites increased 3.3 fold and exhalation rate of purine-CO2 379 fold. Extra-renal elimination at high purine intake was quantitatively similar to humans and closely related to pool size.
authors.affiliation: Institut für Physiologie, Physiologische Chemie und Ernährungsphysiologie, Universität München, FRG.
authors.forename: D
authors.initials: D
authors.lastname: Giesecke
authors.forename: S
authors.initials: S
authors.lastname: Gaebler
authors.forename: M
authors.initials: M
authors.lastname: Stangassinger
mesh_terms: D000481:Allantoin / Q000652:urine; D000818:Animals; D004032:Diet; D004285:Dogs; D005260:Female; D007262:Infusions, Intravenous; D008297:Male; D011687:Purines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014527:Uric Acid / Q000008:administration & dosage / Q000652:urine
chemical_list: D011687:Purines; D014527:Uric Acid; D000481:Allantoin