[The induction of stomach cancer in monkeys with N-methyl-N'-nitro-N-nitrosoguanidine].
Gastric tumors were detected in 2 out of 9 apes following MNNG treatment with a total dose of 800-848 mg/kg (40 mg/kg, thrice a month, 49-50 weeks, via gastric probe). The characteristics, course, symptoms and histologic patterns of the tumors proved comparable with similar neoplasms in humans.
Sharashidze
L K
LK
Beniashvili
D Sh
DSh
Sherenesheva
N I
NI
Turkiia
N G
NG
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008252:Macaca fascicularis; D008297:Male; D008992:Monkey Diseases / Q000139:chemically induced* / Q000473:pathology; D009604:Nitrosoguanidines / Q000633:toxicity*; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors
D009604:Nitrosoguanidines
Induktsiia raka zheludka u obez'ian N-metil-N'-nitro-N-nitrozoguanidinom.