title: Fast and sensitive multiple sequence alignments on a microcomputer.
abstract: A strategy is described for the rapid alignment of many long nucleic acid or protein sequences on a microcomputer. The program described can handle up to 100 sequences of 1200 residues each. The approach is based on progressively aligning sequences according to the branching order in an initial phylogenetic tree. The results obtained using the package appear to be as sensitive as those from any other available method.
authors.affiliation: Department of Genetics, Trinity College, Dublin, Ireland.
authors.forename: D G
authors.initials: DG
authors.lastname: Higgins
authors.forename: P M
authors.initials: PM
authors.lastname: Sharp
mesh_terms: D000465:Algorithms; D001483:Base Sequence; D008838:Microcomputers; D010449:Peptide Mapping; D010802:Phylogeny; D011237:Predictive Value of Tests; D011381:Programming Languages; D012689:Sequence Homology, Nucleic Acid