[Nephrogenous diabetes insipidus caused by amphotericin B].
A patient on systemic amphotericin B therapy developed polyuria with low osmolarity of the urine probably due to nephrogenic diabetes insipidus. This rarely reported side effect of amphotericin B appears not to necessitate discontinuation of the treatment provided adequate fluid intake can be guaranteed. The diabetes insipidus is reversible in 2-6 months after cessation of the treatment: in our patient the polyuria and the low urine osmolarity disappeared within a few days.
Bender
P P
PP
Dumas
A M
AM
Brinkhorst
A P
AP
D000368:Aged; D000666:Amphotericin B / Q000009:adverse effects* / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy; D003919:Diabetes Insipidus / Q000139:chemically induced*; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D011141:Polyuria / Q000139:chemically induced*; D014556:Urine
D000666:Amphotericin B
Door amfotericine B opgewekte nefrogene diabetes insipidus.