title: Acetylator phenotype in psoriasis.
abstract: Acetylator phenotype has been determined with sulfamethazine in 64 psoriatic patients and in 157 normal control subjects. Forty patients (62.5%) versus 90 control subjects (57.3%) were slow acetylators (p = NS). However, 81% of the 27 patients with psoriatic siblings were slow acetylators (p less than 0.05). Slow acetylator phenotype may be a genetic risk factor for the development of psoriasis.
authors.affiliation: Department of Medicine, Hospital Universitario San Carlos, Universidad Complutense, Madrid, Spain.
authors.forename: L C
authors.initials: LC
authors.lastname: Jiménez-Nieto
authors.forename: J M
authors.initials: JM
authors.lastname: Ladero
authors.forename: M J
authors.initials: MJ
authors.lastname: Fernández-Gundín
authors.forename: A
authors.initials: A
authors.lastname: Robledo
mesh_terms: D000107:Acetylation; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D013418:Sulfamethazine / Q000378:metabolism
chemical_list: D013418:Sulfamethazine