A gene homologous to plasminogen located on human chromosome 2q11-p11.
A plasminogen probe encoding kringles 1-3 detects homologous loci on human chromosomes 6 and 2 by somatic cell hybrid analysis. Regional localization by in situ hybridization places the loci at 6q26-27 and 2p11-q11. Further analysis by varying washing stringencies of hybridization filters reveals a greater homology with the chromosome 6 locus than with the chromosome 2 locus. These results confirm localization of the plasminogen gene to human chromosome 6q26-27 and indicate that a homologous sequence of unknown identity resides on chromosome 2p11-q11.
Frank
S L
SL
Department of Microbiology, School of Medicine, University of California, Los Angeles 90024.
Klisak
I
I
Sparkes
R S
RS
Lusis
A J
AJ
D002889:Chromosomes, Human, Pair 2; D002896:Chromosomes, Human, Pair 6; D015342:DNA Probes; D006801:Humans; D009693:Nucleic Acid Hybridization; D010958:Plasminogen / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D015342:DNA Probes; D010958:Plasminogen