Haloperidol reduction can be assayed in human red blood cells.
One metabolite of haloperidol present in plasma is "reduced haloperidol." This study demonstrates that human red blood cells are capable of converting haloperidol to reduced haloperidol in vitro. The reductase involved requires NADPH, as does haloperidol (ketone) reductase in human liver cytosol.
Inaba
T
T
Department of Pharmacology, Faculty of Medicine, University of Toronto, Ont., Canada.
Kalow
W
W
Someya
T
T
Takahashi
S
S
Cheung
S W
SW
Tang
S W
SW
D000328:Adult; D000429:Alcohol Oxidoreductases / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D006220:Haloperidol / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008297:Male; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction
D009249:NADP; D000429:Alcohol Oxidoreductases; C063466:haloperidol reductase; D006220:Haloperidol