Prenatal diagnosis of HIV infection: two attempts using fetal blood sampling.
Blood samples were studied, prior to medical terminations of pregnancy, in two second trimester fetuses with HIV-positive mothers. Fetal blood was obtained from the umbilical vein under ultrasound guidance. No evidence of infection was found in either fetus. In particular, lymphocyte subpopulations were at normal levels and cultures yielded no reverse transcriptase activity. Postmortem findings were normal. Reliable means for prenatal diagnosis of HIV infection, with a minimal risk of false-negative results, have yet to be developed. However, further studies using fetal blood sampling should be useful for the management of HIV-positive pregnancies.
Daffos
F
F
Service de Médecine et de Biologie Foetales, Hôpital Claude Bernard, Paris, France.
Forestier
F
F
Mandelbrot
L
L
Pialoux
G
G
Rey
M A
MA
Brun-Vezinet
F
F
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis*; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D005315:Fetal Diseases / Q000175:diagnosis*; D015483:HIV Antibodies / Q000032:analysis*; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis; D011296:Prenatal Diagnosis
D015483:HIV Antibodies