Effect of neonatal or later capsaicin treatment on bronchial reactivity in sensitized rats. Relation to humoral changes.
Treatment of ovalbumin-sensitized rats with capsaicin resulted in altered bronchial reactivity to both ovalbumin and serotonin. The increase in bronchial reactivity to ovalbumin in neonatally capsaicin-treated rats compared to animals only sensitized may be influenced by the changed ratios of IgA, IgE, and IgG antibodies, together with the inflammation in the lung. Thus, capsaicin given neonatally inhibited the formation of antibodies, both specific titers and total levels, in bronchial lavage.
Nilsson
G
G
Department of Allergy and Immunology, Pharmacia Diagnostics, Uppsala, Sweden.
Alving
K
K
Lundberg
J M
JM
Ahlstedt
S
S
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D001980:Bronchi / Q000187:drug effects*; D001985:Bronchial Provocation Tests; D001986:Bronchial Spasm / Q000503:physiopathology*; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis; D002211:Capsaicin / Q000008:administration & dosage*; D007132:Immunoglobulin Isotypes / Q000032:analysis; D051381:Rats; D012701:Serotonin / Q000494:pharmacology
D007132:Immunoglobulin Isotypes; D012701:Serotonin; D002211:Capsaicin