title: Technetium-99m complexes of dimethylaminomethylene diphosphonate (DMAD)--I. Anion exchange HPLC characterization of 99mTc(NaBH4)-DMAD mixtures.
abstract: Radiopharmaceutical analogs prepared by sodium borohydride reduction of 99mTcO4- in the presence of DMAD have been characterized by anion exchange HPLC (high performance liquid chromatography) separation of the resulting mixture into component 99mTc-DMAD complexes. The distribution of complexes within a radiopharmaceutical formulation can be manipulated by controlling technetium concentration, pH, presence or absence of air, and time post reaction.
authors.affiliation: Department of Chemistry, University of Cincinnati, OH 45221.
authors.forename: M E
authors.initials: ME
authors.lastname: Holland
authors.forename: W R
authors.initials: WR
authors.lastname: Heineman
authors.forename: E
authors.initials: E
authors.lastname: Deutsch
mesh_terms: D001894:Borohydrides / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D004164:Diphosphonates / Q000138:chemical synthesis*; D009942:Organometallic Compounds / Q000138:chemical synthesis*; D015609:Organotechnetium Compounds; D013667:Technetium / Q000032:analysis
chemical_list: D001894:Borohydrides; D004164:Diphosphonates; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; C059662:technetium Tc 99m (sodium borohydride)-dimethylaminomethylene diphosphonate; D013667:Technetium