Calicheamicins, a novel family of antitumor antibiotics: taxonomy, fermentation and biological properties.
A novel family of antitumor antibiotics, the calicheamicins, were isolated from the fermentation broth of Micromonospora echinospora subsp. calichensis. These antibiotics exhibited significant activity against Gram-positive and Gram-negative bacteria in vitro. Calicheamicin gamma 1I demonstrated antitumor activity against P388 leukemia and B16 melanoma in vivo.
Maiese
W M
WM
Medical Research Division, American Cyanamid Company, Lederle Laboratories, Pearl River, New York 10965.
Lechevalier
M P
MP
Lechevalier
H A
HA
Korshalla
J
J
Kuck
N
N
Fantini
A
A
Wildey
M J
MJ
Thomas
J
J
Greenstein
M
M
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects*; D003470:Culture Media; D053281:Enediynes; D005285:Fermentation; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice; D008847:Micromonospora / Q000145:classification / Q000254:growth & development / Q000378:metabolism*; D012988:Soil Microbiology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D053281:Enediynes; C055955:calicheamicin gamma(1)I