[Effect of taktivin on diuresis and tubular cardiotrast secretion in the kidney].
The effect of a new immunomodulator taktivin (7-20 micrograms/kg subcutaneously, for 6 days) on the diuresis and tubular transport of cardiotrast (diodrast) was studied on rats. taktivin was shown to increase the tubular transport of the xenobiotic without significant changes in glomerular filtration and renal excretion of water, sodium, potassium, uric acid and creatinine. Possible mechanism of taktivin's action on the tubular transport of xenobiotics is discussed.
Arion
V Ia
VIa
Berkhin
E B
EB
Galiuteva
G I
GI
Ul'ianov
G P
GP
Sanina
I V
IV
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007468:Iodopyracet / Q000493:pharmacokinetics*; D007684:Kidney Tubules / Q000187:drug effects* / Q000502:physiology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D013949:Thymus Extracts / Q000494:pharmacology*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin; D007468:Iodopyracet
Vliianie taktivina na mocheotdelenie i kanal'tsevuiu sekretsiiu kardiotrasta v pochke.