[Age-related characteristics of cholinergic regulation of the biomechanical function of the rat heart in hypoxia].
Hypoxia is shown to decrease chronotropic and inotropic responses of the isolated heart of mature rats to stimulation of M-choline receptors. In aged tissue hypoxia has no influence on the inotropic response to carbocholine effect. The results permit a conclusion to be made on the higher resistance of cholinergic mechanisms that regulate the cardiac function to hypoxic effects in aged animals.
Lobanok
L M
LM
Kirienkov
A E
AE
D000367:Age Factors; D000818:Animals; D006321:Heart / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D009200:Myocardial Contraction; D051381:Rats; D011950:Receptors, Cholinergic / Q000502:physiology*
D011950:Receptors, Cholinergic
Vozrastnye osobennosti kholinergicheskoĭ reguliatsii biomekhanicheskoĭ funktsii serdtsa krys v usloviiakh gipoksii.