Ocular absorption of benzydamine by the rabbit.
An aqueous solution of 0.15 per cent benzydamine hydrochloride, a non-steroidal anti-inflammatory drug, was applied to the rabbit eye. Following topical application to the cornea, the drug was soon detected in the aqueous fluid of the treated eye, whereas the plasma levels were negligible. The possibility that benzydamine can inhibit inflammatory processes in the eye without the risk of side-effects is discussed.
Catanese
B
B
F. Angelini Research Institute, Rome, Italy.
Valeri
P
P
Lagana
A
A
Curini
L
L
D000042:Absorption; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001591:Benzydamine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005123:Eye / Q000378:metabolism*; D008297:Male; D009883:Ophthalmic Solutions; D011720:Pyrazoles / Q000493:pharmacokinetics*; D011817:Rabbits
D009883:Ophthalmic Solutions; D011720:Pyrazoles; D001591:Benzydamine