Hyaluronate in healing of corneal alkali wound in the rabbit.
The effect of topically applied 1% and 2% sodium hyaluronate was studied on the healing of a standardized rabbit corneal alkali wound. The healing of the epithelium, the stroma, and the endothelium was evaluated separately by applying quantitative methods. The healing was followed for 8 weeks. Both 1% and 2% sodium hyaluronate have a statistically significant positive influence on the epithelial re-surfacing, especially during the late healing phase. Furthermore, sodium hyaluronate has a positive healing influence on the stromal healing at a certain time interval during the observation period. This was reflected as a better maintained stromal dry mass level compared to control. The stromal healing was parallel to a faster re-surfacing of the endothelium.
Chung
J H
JH
Department of Ophthalmology, Karolinska Hospital, Stockholm, Sweden.
Fagerholm
P
P
Lindström
B
B
D000287:Administration, Topical; D000468:Alkalies; D000818:Animals; D002057:Burns, Chemical / Q000188:drug therapy*; D065306:Corneal Injuries; D003319:Corneal Stroma / Q000187:drug effects; D004728:Endothelium, Corneal / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects; D005126:Eye Burns / Q000139:chemically induced* / Q000188:drug therapy; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D012972:Sodium Hydroxide; D014945:Wound Healing / Q000187:drug effects*
D000468:Alkalies; D012972:Sodium Hydroxide; D006820:Hyaluronic Acid