title: [Nephrogenous diabetes insipidus caused by amphotericin B].
abstract: A patient on systemic amphotericin B therapy developed polyuria with low osmolarity of the urine probably due to nephrogenic diabetes insipidus. This rarely reported side effect of amphotericin B appears not to necessitate discontinuation of the treatment provided adequate fluid intake can be guaranteed. The diabetes insipidus is reversible in 2-6 months after cessation of the treatment: in our patient the polyuria and the low urine osmolarity disappeared within a few days.
authors.forename: P P
authors.initials: PP
authors.lastname: Bender
authors.forename: A M
authors.initials: AM
authors.lastname: Dumas
authors.forename: A P
authors.initials: AP
authors.lastname: Brinkhorst
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000009:adverse effects* / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy; D003919:Diabetes Insipidus / Q000139:chemically induced*; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D011141:Polyuria / Q000139:chemically induced*; D014556:Urine
chemical_list: D000666:Amphotericin B
vernacular_title: Door amfotericine B opgewekte nefrogene diabetes insipidus.