In vivo and in vitro genotoxic evaluation of indorenate.
5-Methoxytryptamine, beta-methylcarboxylate hydrochloride (indorenate) is a new antihypertensive serotonin derivative. We evaluated its genotoxic activity using the mouse bone marrow and cytogenetic test and the human lymphocyte culture cytogenetic assay. As endpoints we measured chromosomal aberrations, sister-chromatid exchanges and cellular proliferation kinetics. Our results agree in both systems showing that indorenate is a non-genotoxic agent in these assays.
Madrigal-Bujaidar
E
E
Depto. de Morfología, Escuela Nacional de Ciencias Biológicas, I.P.N. Carpio y Plan de Ayala, Mexico, D.F.
Rosas-Planaguma
E
E
D008735:5-Methoxytryptamine / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002455:Cell Division / Q000187:drug effects; D002869:Chromosome Aberrations; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D012701:Serotonin / Q000031:analogs & derivatives*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D012701:Serotonin; D008735:5-Methoxytryptamine; C033600:indorenate