Luffolide, a novel anti-inflammatory terpene from the sponge Luffariella sp..
Luffolide (4) is a minor metabolite of the sponge Luffariella sp. from Palau. The structure of luffolide was determined by single crystal X-ray analysis. Luffolide is relatively unstable and undergoes a complex cyclization reaction to give the hexacyclic products 5 and 6. Luffolide (4) has some of the anti-inflammatory properties of manoalide (1): this may help to define the chemical reaction between manoalide (1) and phospholipase A2.
Kernan
M R
MR
Scripps Institution of Oceanography. La Jolla, California.
Faulkner
D J
DJ
Parkanyi
L
L
Clardy
J
J
de Carvalho
M S
MS
Jacobs
R S
RS
D000818:Animals; D007249:Inflammation / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D054467:Phospholipases A2; D011161:Porifera / Q000032:analysis*; D013055:Spectrophotometry, Infrared; D013729:Terpenes / Q000494:pharmacology / Q000627:therapeutic use; D014961:X-Ray Diffraction
D013729:Terpenes; C059349:luffolide; C045673:manoalide; D010741:Phospholipases A; D054467:Phospholipases A2