title: Does membrane-associated DNA play a role in the establishment of hormonal imprinting in the unicellular Tetrahymena?
abstract: Treatment of Tetrahymena with DNase considerably reduced the FITC-insulin binding capacity of the unicellular organism, but a normalization of the binding value followed after 24 h. DNase equally prevented imprinting in Tetrahymena when applied before or after insulin. It appears that membrane-associated DNA plays an important role in the hormone binding of Tetrahymena, and also presumably in the development and/or stabilization of hormonal imprinting.
authors.affiliation: Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Csaba
authors.forename: Z
authors.initials: Z
authors.lastname: Darvas
authors.forename: V
authors.initials: V
authors.lastname: László
authors.forename: P
authors.initials: P
authors.lastname: Kovács
mesh_terms: D000818:Animals; D004247:DNA / Q000502:physiology*; D003851:Deoxyribonucleases; D007328:Insulin / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism*; D013768:Tetrahymena / Q000235:genetics* / Q000502:physiology
chemical_list: D007328:Insulin; D004247:DNA; D011972:Receptor, Insulin; D003851:Deoxyribonucleases