[Adverse effects of drug metaphylaxis of urolithiasis].
The authors examined 133 patients with urolithiasis, treated with hydrochlorothiazide and 81 patients treated with allopurinol. In those treated with hydrochlorothiazide the calciuria and Ca/creat. index declined, and uricaemia rose. After treatment uricosuria increased significantly in 41% patients. The detection of diabetes did not exceed the prevalence in the population. In patients treated with allopurinol the uricaemia and uricosuria declined, a hepatic disorder with supraliminal rise of ALT was recorded in 23% of the patients and led to discontinuation of treatment in 15% of the patients.
Tuíková
J
J
Kocvara
R
R
D000493:Allopurinol / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects* / Q000627:therapeutic use; D014527:Uric Acid / Q000378:metabolism; D014545:Urinary Calculi / Q000188:drug therapy / Q000378:metabolism*
D006852:Hydrochlorothiazide; D014527:Uric Acid; D000493:Allopurinol
K nĕkterým nezádoucím úcinkům medikamentózní metafylaxe urolitiázy.