Synthesis and antileukemic activity of 1-[(quinolizidinylalkyl)amino]4/7-R-thioxanthen-9-ones.
Fifteen 1-(quinolizidinylalkyl)amino derivatives of thioxanthenone bearing different substituents on position 4 and 7 were prepared and tested in mice against lymphocytic leukemia P 388. These compounds were inactive or displayed only borderline activity (compounds 1, 10, 15).
Boido Canu
C
C
Istituto di Sicenze Farmaceutiche, Università di Genova, Italy.
Iusco
G
G
Boido
V
V
Sparatore
F
F
Sparatore
A
A
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007941:Leukemia P388 / Q000188:drug therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D011807:Quinolizines / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013892:Thioxanthenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D011807:Quinolizines; D013892:Thioxanthenes