Glucocorticoids potentiate kainic acid-induced seizures and wet dog shakes.
Glucocorticoid effects on kainic acid-induced motor seizures and wet dog shakes in rats were investigated by adrenalectomy and dexamethasone treatment. One-day adrenalectomy attenuated kainic acid-induced wet dog shakes and seizure activity. These effects were restored by dexamethasone. Administration of dexamethasone to non-adrenalectomized rats potentiated kainic acid-induced wet dog shakes and severity of seizure activity. These results suggest that glucocorticoids may play an important role in modulating the severity of kainic acid-induced seizures and wet dog shakes.
Lee
P H
PH
Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Grimes
L
L
Hong
J S
JS
D000315:Adrenalectomy; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005938:Glucocorticoids / Q000494:pharmacology / Q000502:physiology*; D007608:Kainic Acid; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology
D005938:Glucocorticoids; D003907:Dexamethasone; D007608:Kainic Acid