[Jet intravenous injection of erythromycin lactobionate. A possible cause of the occurrence of crisis in torsade de pointe].
The authors report one case of torsade de pointe which occurred immediately after fast intravenous injection of a 1-gram dose of erythromycin lactobionate in a female patient who had undergone surgical replacement of the mitral and triscuspid valves 24 hours before. The responsibility of erythromycin was strongly suggested by the clinical data (syncope), electrocardiographic findings (electrocardiogram typical of torsade de pointe, slow rhythm and lengthened QT interval in the basal ECG) and the chronology of the sequence of intravenous injection of the antibiotic and the rhythm disorder. A literature search revealed six similar cases. Its seems that the arrythmogenic property of this drug is related to abnormally elevated serum levels following rapid administration.
Camilleri
J F
JF
Service de Chirurgie Cardiaque, Groupe Hospitalier de la Timone, Marseille.
Deharo
J C
JC
Panagidès
D
D
Broin
P
P
Mésana
T
T
Blin
D
D
Mouly-Bandini
A
A
Dubouloz
C
C
Goudard
A
A
Montiès
J R
JR
D004917:Erythromycin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous / Q000295:instrumentation; D007277:Injections, Jet; D008875:Middle Aged; D013610:Tachycardia / Q000139:chemically induced*
C010948:erythromycin lactobionate; D004917:Erythromycin
Injection en flash intraveineux de lactobionate d'érythromycine. Une cause possible de survenue d'accès de torsade de pointe.