[Cisplatin (platidiam) and the prospects for using complex platinum compounds in the clinical chemotherapy of malignant tumors].
The paper discusses the results of combination chemotherapy of 652 patients using platinum derivatives. The treatment proved effective in patients with metastatic tumors (79.7%), ovarian cancer (71.2%) and breast carcinoma (71.2%). Longer survival was obtained in cases of complete regression of ovarian tumor and in effectively treated patients with breast cancer. Response was registered in 30.8% of cases of osteogenic sarcoma. Application of cisplatin in chemoradiation treatment for inoperable bladder cancer resulted in regression of tumor in 57.4%. Literature data on some newly developed platinum derivatives undergoing phase-I and -II clinical trials outside the USSR are discussed.
Gorbunova
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VA
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000401:mortality; D009944:Organoplatinum Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D010984:Platinum / Q000009:adverse effects / Q000627:therapeutic use*; D012074:Remission Induction
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D010984:Platinum; D002945:Cisplatin
Tsiplatin (platidiam) i perspektivy ispol'zovaniia kompleksnykh soedineniĭ platiny v klinicheskoĭ khimioterapii zlokachestvennykh opukholeĭ.