Mutagens in urine of non-smoking and smoking workers in an aircraft tyre retreading plant. Skin exposure as a causal factor?
In an aircraft type retreading plant environmental samples taken at several departments showed mutagenic properties. Thursday urine samples of non-smoking and smoking workers showed higher urinary mutagenicity than urine samples collected on Sundays, thus suggesting occupational exposure to mutagenic substances. A relation between urinary mutagenicity on Thursdays and skin contamination measured on Wednesdays was observed. The data suggest that intake through the skin plays an important role in the occupational exposure to mutagenic compounds of rubber workers.
Bos
R P
RP
Department of Toxicology, Faculty of Medicine, University of Nijmegen, The Netherlands.
Kromhout
H
H
Ikink
H
H
de Haan
W
W
Koppejan
J
J
Theuws
J L
JL
D000395:Air Pollutants, Occupational / Q000032:analysis; D002869:Chromosome Aberrations; D003510:Cyclohexanes; D006801:Humans; D009153:Mutagens / Q000652:urine*; D009784:Occupational Diseases / Q000652:urine*; D012408:Rubber; D012907:Smoking; D012997:Solvents
D000395:Air Pollutants, Occupational; D003510:Cyclohexanes; D009153:Mutagens; D012997:Solvents; D012408:Rubber