title: [Cytogenetic control over the safety of merthiolate].
abstract: The capacity of merthiolate (also known as thimerosal), a mercury organic compound used as preservative in vaccines, to induce chromosomal aberrations was studied in vivo in experiments on mice. The metaphasic method of the registration of anomalies was used. In a dose of 3.3 micrograms/kg body weight merthiolate did not produce a damaging effect on the chromosomes of marrow, spleen and embryonal liver cells. Cyclophosphamide (in a dose of 25-50 micrograms/kg) used as positive control induced a significant rise in the frequency of chromosomal transformations.
authors.forename: G M
authors.initials: GM
authors.lastname: Volgareva
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000009:adverse effects / Q000633:toxicity; D002869:Chromosome Aberrations / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D005035:Ethylmercury Compounds / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010592:Pharmaceutic Aids; D011514:Proteus vulgaris / Q000276:immunology; D013849:Thimerosal / Q000009:adverse effects* / Q000633:toxicity; D013997:Time Factors
chemical_list: D001428:Bacterial Vaccines; D005035:Ethylmercury Compounds; D010592:Pharmaceutic Aids; D013849:Thimerosal
vernacular_title: Tsitogeneticheskiĭ kontrol' bezvrednosti mertiolata.