Budesonide reduces sensitivity to antigen but does not alter baseline tone or responsiveness to carbachol, terbutaline, and enprofylline in IgE-sensitized guinea-pig tracheae.
In vitro incubation of IgE-sensitized guinea-pig tracheal rings with 10(-7) M budesonide for 24 h significantly shifted the concentration-response curve to antigen by 5-fold to the right. Smooth muscle characteristics such as baseline tone, muscarinic contraction or relaxation to beta 2-receptor agonists and xanthines were not or only marginally affected by this exposure of airway tissue to a glucocorticoid drug. It is concluded that budesonide reduced anaphylactic IgE-driven release of contractile mediators.
Persson
C G
CG
Department of Clinical Pharmacology, University Hospital of Lund, Sweden.
Andersson
P T
PT
Gustafsson
B
B
D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D019819:Budesonide; D002217:Carbachol / Q000494:pharmacology; D004347:Drug Interactions; D005938:Glucocorticoids / Q000494:pharmacology*; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000502:physiology; D066298:In Vitro Techniques; D010047:Ovalbumin / Q000276:immunology; D011282:Pregnenediones / Q000494:pharmacology*; D013726:Terbutaline / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects / Q000276:immunology; D014970:Xanthines / Q000494:pharmacology
D005938:Glucocorticoids; D011282:Pregnenediones; D014970:Xanthines; D007073:Immunoglobulin E; D019819:Budesonide; D002217:Carbachol; D010047:Ovalbumin; C034347:enprofylline; D013726:Terbutaline