title: Sinoaortic denervation attenuates the reflex responses to hypotension in fetal sheep.
abstract: Hypotension in fetal sheep stimulates reflex decreases in heart rate and increases in the secretion of several hormones, including adrenocorticotropin (ACTH), cortisol, vasopressin, and renin. However, little is known about the afferent limb(s) of the reflex(es) controlling these responses. Fetal sheep between 122 and 134 days gestation were prepared with chronic vascular catheters, intravascular balloon-tipped catheters, and amniotic fluid catheters. Seven fetal sheep were also subjected to sinoaortic denervation, and nine remained intact. After recovery from surgery for 2-5 days, fetuses were subjected to a 10-min period of hypotension produced by vena caval obstruction, produced by inflation of balloons in the superior and inferior venae cavae. Vena caval obstruction produced decreases in fetal heart rate and increases in fetal plasma ACTH, vasopressin, and renin activity, which were related to the degree of hypotension. Prior sinoaortic denervation attenuated all of these responses. It is concluded that afferent fibers in the carotid sinus and/or aortic depressor nerves mediate part of the heart rate, ACTH, vasopressin, and renin responses to vena caval obstruction in late-gestation fetal sheep.
authors.affiliation: Department of Physiology, University of Florida College of Medicine, Gainesville 32610.
authors.forename: C E
authors.initials: CE
authors.lastname: Wood
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology*; D001784:Blood Gas Analysis; D002346:Carotid Sinus / Q000502:physiology*; D003251:Constriction, Pathologic; D003714:Denervation; D005260:Female; D005312:Fetal Blood; D005333:Fetus / Q000502:physiology*; D006728:Hormones / Q000097:blood; D006863:Hydrogen-Ion Concentration; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology*; D011247:Pregnancy; D012018:Reflex / Q000502:physiology*; D012756:Sheep; D014684:Venae Cavae
chemical_list: D006728:Hormones