Translocation of zinc may contribute to seizure-induced death of neurons.
Rats were subjected to seizures induced by kainic acid, and the resulting changes in CNS zinc staining were studied with the toluene sulfonamide quinoline fluorescence method. Seizures caused a loss of zinc staining from presynaptic boutons in many limbic and cerebrocortical regions. Simultaneously, the postsynaptic neurons that were degenerating (acidophilic) in those regions as a result of the seizure developed intense fluorescence for zinc. A possible role for zinc in the death of the postsynaptic neurons is suggested.
Frederickson
C J
CJ
Laboratory for Neurobiology, University of Texas at Dallas, Richardson 75080.
Hernandez
M D
MD
McGinty
J F
JF
D000679:Amygdala / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D002470:Cell Survival; D002531:Cerebellum / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D066298:In Vitro Techniques; D007608:Kainic Acid; D009410:Nerve Degeneration; D011804:Quinolines; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D013449:Sulfonamides; D014050:Toluene; D015032:Zinc / Q000378:metabolism*
D011804:Quinolines; D013449:Sulfonamides; D014050:Toluene; D015032:Zinc; D007608:Kainic Acid