title: Does ergometric stress test induce a procoagulative condition in patients with previous myocardial infarction?
abstract: A regularly scheduled physical training program seems to have antithrombotic effects. Moreover, the hemostatic changes occurring in patients with coronary artery disease during acute exercise have not been clearly elucidated. Since stress testing is routinely performed in clinical cardiology, it would be helpful to assess whether patients with coronary artery disease are exposed to acute coronary thrombosis during or soon after sustained physical exercise. This study was designed to evaluate the effect of acute physical exercise (stress test by bicycle ergometer) on blood coagulation in a group of patients with previous myocardial infarction, and to determine whether the antithrombotic therapy commonly administered favorably influences hemostatic equilibrium. Our results suggest that exercise testing is not harmful to patients with previous myocardial infarction in regard to hemostasis and fibrinolysis and that antithrombotic therapy reduces postexercise increase in platelets.
authors.affiliation: Istituto di Clinica Medica IV, Università degli Studi di Firenze, Florence, Italy.
authors.forename: M
authors.initials: M
authors.lastname: De Scalzi
authors.forename: D
authors.initials: D
authors.lastname: Rafanelli
authors.forename: V
authors.initials: V
authors.lastname: de Leonardis
authors.forename: A
authors.initials: A
authors.lastname: Becucci
authors.forename: S
authors.initials: S
authors.lastname: Cinotti
authors.forename: E
authors.initials: E
authors.lastname: Filimberti
authors.forename: G
authors.initials: G
authors.lastname: Longo
authors.forename: C
authors.initials: C
authors.lastname: Lusini
authors.forename: L
authors.initials: L
authors.lastname: Brardi
authors.forename: P
authors.initials: P
authors.lastname: Cinelli
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use; D001777:Blood Coagulation; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy
chemical_list: D000925:Anticoagulants