[Fluorescence diagnosis of porphyrin-marked urothelial tumors. Status of experimental development].
On the basis of selective storage of fluorescing hematoporphyrin derivative (HpD) in tumors, a method has been developed that enables the endoscopic detection of early-stage cancer by monitoring fluorescent images. The contrast-reducing portion of the superposed tissue autofluorescence is suppressed by the use of two-wavelength excitation and subsequent image processing in realtime. The amount of photosensitizing HpD necessary for diagnostic purposes is considerably reduced by means of sensitive detection devices. A clear distinction between benign and malignant bladder tissue seems possible according to the results of animal studies.
Jocham
D
D
Urologische Klinik und Poliklinik LMU München.
Baumgartner
R
R
Fuchs
N
N
Lenz
H
H
Stepp
H
H
Unsöld
E
E
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000175:diagnosis*; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced / Q000175:diagnosis*; D020684:Cystoscopes; D005453:Fluorescence; D006415:Hematoporphyrins; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D007834:Lasers; D051381:Rats; D011919:Rats, Inbred Strains; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000175:diagnosis*
D006415:Hematoporphyrins
Die Fluoreszenzdiagnose Porphyrin-markierter urothelialer Tumoren. Stand der experimentellen Entwicklung.