title: Immune correlates of stress and depression.
abstract: This paper reviews the evidence for alterations in immunity associated with depression and stressful events. The reviewed studies examine a variety of immune parameters (e.g., mitogen response, natural killer cell activity and number, T-cell, and T-cell subpopulations) in relation to depression and in relation to a number of stressful events (e.g., death of spouse, examinations). There is considerable variability in the findings of the available studies. However, the review finds considerable evidence for an association between a variety of stressful events and lowered immunity and between severe depression and lowered immunity. The clinical relevance of these psychoimmune relationships remains in question.
authors.forename: D L
authors.initials: DL
authors.lastname: Evans
authors.forename: J
authors.initials: J
authors.lastname: Leserman
authors.forename: C A
authors.initials: CA
authors.lastname: Pedersen
authors.forename: R N
authors.initials: RN
authors.lastname: Golden
authors.forename: M H
authors.initials: MH
authors.lastname: Lewis
authors.forename: J A
authors.initials: JA
authors.lastname: Folds
authors.forename: H
authors.initials: H
authors.lastname: Ozer
mesh_terms: D003866:Depressive Disorder / Q000276:immunology*; D006801:Humans; D013315:Stress, Psychological / Q000276:immunology*