title: [Substantia innominata kindling in rats].
abstract: With a combination of electrolytic lesion and choline acetyltransferase histochemistry, Kimura et al. suggested that cholinergic neurons in the substantia innominata (SI) plays an important role in accessing non-motor structure, such as the amygdala (AM), to the motor system during AM kindling. More recent studies demonstrated that intra-SI injection of GABAergic agent or excitatory amino acid antagonist suppresses the kindled generalized convulsion without blocking afterdischarge (AD) generation in the AM. In order to gain further insight into the role played by the SI in AM kindling, we examined the comparative electroclinical features of AM and SI kindling in addition to the transferability of the SI to the ipsilateral AM. Male Wistar rats were electrically kindled at the left AM or the left SI at the AD threshold (ADT) until five consecutive Stage 5 generalized convulsions were evoked. Subsequently, the stimulus intensity was gradually reduced and the last intensity to induce Stage 5 seizure was designated as the generalized seizure triggering threshold (GST). Following the determination of the GST, the SI stimulation was switched to the ipsilateral AM. All the animals were perfused and electrode placements were identified histologically. The electrode placements distributed in the medial SI (N = 5), lateral SI (N = 9), Globus Pallidum (GP) (N = 5) and Nucleus Accumbens (NA) (N = 2). All electrodes of the AM (N = 9) were located within the AM. The 3/5 of GP rats kindled, while the 2/5 did not kindle. The 2/2 of NA rats kindled.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical College, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hoshino
authors.forename: N
authors.initials: N
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Kumashiro
mesh_terms: D000679:Amygdala / Q000503:physiopathology; D000818:Animals; D001479:Basal Ganglia / Q000503:physiopathology*; D004558:Electric Stimulation; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology; D013377:Substantia Innominata / Q000503:physiopathology*