title: A substance resembling somatomedin C in the American cockroach.
abstract: Material antigenically resembling somatomedin C (type I insulin-like growth factor, IGF-I) is demonstrated in the American cockroach Periplaneta americana by means of a monoclonal antibody immunoperoxidase technique. It was localized histochemically in neuronal cell somata and axonal fibers (probably interneurons) of the central nervous/neuroendocrine system and in 'endocrine-type' cells lining the midgut epithelium. The IGF-I-like substance is different from vertebrate insulin and also distinct from materials immunostained by different insulin antibodies in the brain and neurohaemal complex of this insect species. These findings are viewed in the light of recent reports on the presence and action of insulin-like chemicals in insects, and with respect to the existence of an insect brain-midgut system similar to the mammalian brain-gastroenteropancreatic system.
authors.affiliation: University of Waterloo, Department of Biology, Ont., Canada.
authors.forename: P D
authors.initials: PD
authors.lastname: Verhaert
authors.forename: R G
authors.initials: RG
authors.lastname: Downer
authors.forename: R
authors.initials: R
authors.lastname: Huybrechts
authors.forename: A
authors.initials: A
authors.lastname: De Loof
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D001923:Brain Chemistry; D003058:Cockroaches / Q000378:metabolism*; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D013002:Somatomedins / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I