Ha-ras oncogene product in human oral squamous cell carcinoma.
The expression of Ha-ras oncogene product (Ha-ras p21) in the biopsy or operation materials derived from 70 oral squamous cell carcinomas, 10 oral leukoplakias and 10 normal oral mucosae was examined immunohistochemically using anti-Ha-ras p21 antibody. Ha-ras p21 was detected in 43 (61%) of 70 carcinomas, 3 (30%) of 10 oral leukoplaskias and 3 (30%) of 10 normal oral mucosae. Patients with Ha-ras p21-positive carcinomas had a significantly worse prognosis than those with Ha-ras p21-negative carcinomas. These observations strongly suggest that the expression of Ha-ras p21 is a common event in oral squamous cell carcinomas, and that Ha-ras p21 serves as a tissue tumor marker for determining the prognosis of patients with oral squamous cell carcinomas.
Oku
N
N
Shimada
K
K
Itoh
H
H
D002294:Carcinoma, Squamous Cell / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007972:Leukoplakia, Oral / Q000032:analysis; D009061:Mouth Mucosa / Q000032:analysis; D009062:Mouth Neoplasms / Q000032:analysis*; D015689:Oncogene Protein p21(ras) / Q000032:analysis*; D011379:Prognosis
D015689:Oncogene Protein p21(ras)