Ependymomas in two sisters and a maternal male cousin with mosaicism with monosomy 22 in tumour.
A family with two sisters and their mother's male cousin had ependymomas. Of note is the fact that chromosome analysis on the tumour of the younger sister showed two cell lines, one a normal female line, the other with monosomy of chromosome 22.
Savard
M L
ML
Department of Pathology, BC Children's Hospital, Vancouver, Canada.
Gilchrist
D M
DM
D000293:Adolescent; D001932:Brain Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D002675:Child, Preschool; D004806:Ependymoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree