title: Treatment of acute uncomplicated urinary tract infections with single daily doses of cefuroxime axetil.
abstract: Cefuroxime axetil in a single daily dose of 250 mg for ten days was given to 75 women with symptoms of acute uncomplicated urinary tract infections. Fifty-nine women were found to have significant bacteriuria but one was excluded as urethral catheterization was required. The dose was taken at night with a milk drink. Ninety-five per cent of women had a clear urine during treatment. Compliance studies showed that antimicrobial activity was detectable in early morning urines up to 8-10 h after the dose. Post treatment, 93% of women were clear of their original infecting organism but five women had become reinfected with a different strain of Escherichia coli. At the six week follow up 98% of women were still clear although one further reinfection had occurred. The overall cure rate was 86%, including 11% reinfection. Adverse events developed in 17 (23%) of the 75 women with candida vaginitis (8) and diarrhoea (4) being most common. Cefuroxime axetil is a valuable therapy for the treatment of urinary tract infection particularly when due to beta-lactamase producing bacteria.
authors.affiliation: Department of Microbiology, Wycombe General Hospital, Bucks, UK.
authors.forename: D A
authors.initials: DA
authors.lastname: Leigh
authors.forename: G E
authors.initials: GE
authors.lastname: Joy
authors.forename: S
authors.initials: S
authors.lastname: Tait
authors.forename: K
authors.initials: K
authors.lastname: Harris
authors.forename: B
authors.initials: B
authors.lastname: Walsh
mesh_terms: D000208:Acute Disease; D002444:Cefuroxime / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D002511:Cephalosporins; D002444:Cefuroxime; C040738:cefuroxime axetil