Ticarcillin-clavulanate therapy for infections with ticarcillin-resistant microorganisms.
In a prospective study, 46 episodes of serious infection with ticarcillin-resistant microorganisms were treated with the combination ticarcillin disodium and clavulanate potassium (Timentin). Clinical cure was achieved in 35 of the 46 episodes (76%), and microbiologic eradication was achieved in 30 (65%). We found no development of resistance to ticarcillin-clavulanate and observed no serious side effects.
Gelfand
M S
MS
Department of Medicine, Methodist Hospitals of Memphis, TN 38104.
Lawson
R D
RD
Baucom
W
W
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000188:drug therapy*; D002969:Clavulanic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010403:Penicillin Resistance; D010406:Penicillins / Q000627:therapeutic use*; D011446:Prospective Studies; D013982:Ticarcillin / Q000494:pharmacology / Q000627:therapeutic use*
D002969:Clavulanic Acids; D010406:Penicillins; C043215:ticarcillin-clavulanic acid; D013982:Ticarcillin