title: Triethylene melamine-induced sister-chromatid exchange in murine lymphocytes exposed in vivo.
abstract: The induction of sister-chromatid exchange (SCE) by triethylene melamine (TEM), a known animal carcinogen, was investigated in an in vivo exposure/in vitro culture murine lymphocyte assay. Dose-related increases in SCE were observed in B6D2F1 mice following a single i.p. injection of 0.5, 1 or 2 mg/kg TEM. SCE frequencies remained elevated over baseline levels at 24 h post exposure. It is hoped that studies of this nature can determine whether the in vivo/in vitro murine lymphocyte SCE assay is useful for predicting the carcinogenic potential of an agent.
authors.affiliation: Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079.
authors.forename: R E
authors.initials: RE
authors.lastname: Neft
authors.forename: H M
authors.initials: HM
authors.lastname: Schol
authors.forename: D A
authors.initials: DA
authors.lastname: Casciano
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013154:Spleen / Q000166:cytology; D014265:Triethylenemelamine / Q000633:toxicity*
chemical_list: D014265:Triethylenemelamine