title: Convenient oxidation of phenothiazine salts to their sulfoxides with aqueous nitrous acid.
abstract: A simple method is reported for the preparation of gram quantities of phenothiazine sulfoxides by aqueous nitrous acid oxidation of phenothiazines at room temperature. The chiral levomepromazine gave rise to diastereoisomeric products analogous to those reported for thioridazine sulfoxidation.
authors.affiliation: St. Louis University, MO.
authors.forename: M L
authors.initials: ML
authors.lastname: Owens
authors.forename: E C
authors.initials: EC
authors.lastname: Juenge
authors.forename: A
authors.initials: A
authors.lastname: Poklis
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D009608:Nitrous Acid; D010084:Oxidation-Reduction; D010640:Phenothiazines / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013454:Sulfoxides / Q000138:chemical synthesis
chemical_list: D010640:Phenothiazines; D013454:Sulfoxides; D009608:Nitrous Acid