[Acute promyelocytic leukemia with a history of RAEB in transformation and the 15/17 translocation].
A 34-year old female was admitted to our clinic because of fever and general fatigue on March 26, 1987. On admission, peripheral blood (PB) revealed pancytopenia. Bone marrow smears revealed 9. 0% of promyelocytic cells with or without Auer rods. Diagnosis of RAEB in transformation was made. Chromosome study of the bone marrow cells showed t(15; 17) in 3 out of 20 cells analysed. After 3 months, the leukemic cells were observed in PB and increased in number. Then the patient showed bleeding tendency and fibrin degradation products (FDP) increased up to 40 micrograms/ml. And the leukemic cells were over 30% in PB at the end of July, 1987. The diagnosis of APL with DIC was made. To our knowledge, this is the first case of APL with a history of MDS with t(15; 17).
Ogawa
K
K
Shineha
H
H
Abe
R
R
Shichishima
T
T
Kimura
H
H
Yui
T
T
Kawaguchi
M
M
Matsuda
S
S
Uchida
T
T
Kariyone
S
S
D000328:Adult; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics / Q000473:pathology*; D014178:Translocation, Genetic