title: Effects of 3-glucosaminoglycan sulfate on hemorheologic parameters in hyperlipidemic peripheral vascular disease (PVD) patients: a preliminary double-blind crossover study.
abstract: The effects of 3-glucosaminoglycan sulfate on lipids and the hemorheologic parameters were observed in a preliminary double-blind crossover study in 30 hyperlipidemic peripheral vascular disease (PVD) patients. Parenteral administration of the test drug was associated with a reduction in serum lipids, especially in triglyceride levels, and a lowering of fibrinogen, plasma viscosity, and whole blood viscosity levels. These effects justify the drug's use in the treatment of PVD, especially when associated with hypertriglyceridemia and hemorheologic disturbances.
authors.affiliation: 2nd Department of Internal Medicine, Perugia University, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ciuffetti
authors.forename: M
authors.initials: M
authors.lastname: Mercuri
authors.forename: A
authors.initials: A
authors.lastname: Susta
authors.forename: G
authors.initials: G
authors.lastname: Lupattelli
authors.forename: L
authors.initials: L
authors.lastname: Pasqualini
authors.forename: R
authors.initials: R
authors.lastname: Lombardini
authors.forename: E
authors.initials: E
authors.lastname: Mannarino
mesh_terms: D000328:Adult; D001161:Arteriosclerosis / Q000150:complications*; D001809:Blood Viscosity / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006025:Glycosaminoglycans / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D006025:Glycosaminoglycans; D008055:Lipids; C007858:glucuronyl glucosamine glycan sulfate; D005340:Fibrinogen