title: [Biosynthesis of somatotropin in a recombinant strain of Escherichia coli].
abstract: A recombinant Escherichia coli K-12 strain was grown in the regime of chemostat with glucose limitation at a different flow rate and in the regime of turbidostat. The stability of its population and the dynamics of somatotropin biosynthesis were studied. The plasmid-containing strain became less stable as the flow rate in the fermenter dropped down, which was due, apparently, to a greater limitation. The level of somatotropin biosynthesis was higher at a low dilution rate (D = 0.075, 0.17 and 0.34 h-1). Possible factors responsible for this phenomenon are discussed.
authors.forename: N V
authors.initials: NV
authors.lastname: Gorlatova
authors.forename: N V
authors.initials: NV
authors.lastname: Eroshina
authors.forename: V M
authors.initials: VM
authors.lastname: Anan'in
authors.forename: L M
authors.initials: LM
authors.lastname: Baryshnikova
authors.forename: L V
authors.initials: LV
authors.lastname: Akimenko
mesh_terms: D003001:Cloning, Molecular; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D013006:Growth Hormone / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics; D011995:Recombination, Genetic
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone
vernacular_title: Biosintez somatotropina rekombinantnym shtammom Escherichia coli.