[The biological action of radioactive carbon. The metabolic kinetics and biological effects of the combined action of radioactive carbon (14C-glucose) and sodium nitrite chronically administered].
A study was made of the effect of sodium nitrate (3.1 and 0.3 g/l) on the metabolism kinetics and the biological effects of 14C-glucose (13 kBq/rat/day) that were chronically administered to rats. After both separate and combined administration of the radiation and chemical agents, no substantial changes were detected in the kinetics of metabolism and biological effect of 14C. Six months after the onset of the experiment, the reproductive function of the experimental rats was impaired.
Vasilenko
I Ia
IIa
Osipov
V A
VA
Liaginskaia
A M
AM
Loshchilina
T E
TE
Dement'ev
S I
SI
D000042:Absorption; D000818:Animals; D002250:Carbon Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005947:Glucose / Q000378:metabolism; D008136:Longevity / Q000187:drug effects / Q000528:radiation effects; D008325:Mammary Neoplasms, Experimental / Q000453:epidemiology / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology; D009573:Nitrites / Q000633:toxicity*; D051381:Rats; D012098:Reproduction / Q000187:drug effects / Q000528:radiation effects; D012977:Sodium Nitrite / Q000493:pharmacokinetics / Q000633:toxicity*; D013997:Time Factors; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D009573:Nitrites; D005947:Glucose; D012977:Sodium Nitrite
Biologicheskoe deĭstvie radioaktivnogo ugleroda. Kinetika obmena i biologicheskie éffekty sochetannogo deĭstviia radioaktivnogo ugleroda (14C-gliukozy) i nitrita natriia pri khronicheskom vvedenii.