Acute renal failure due to uric acid nephropathy in a patient with renal hypouricemia.
This report is about a 23-year-old man who required hemodialysis in connection with an acute renal failure resulting from uric acid nephropathy without hyperuricemia. After recovering renal function he showed extreme hypouricemia (0.1-0.3 mg/dl) and elevated uric acid clearance (100-300 ml/min). The fractional excretion of uric acid (Cua/Ccr) could be suppressed by oral pyrazinamide and enhanced by probenecid. As no other renal tubular or metabolic abnormalities were detected, it is suggested that a markedly increased renal tubular urate secretion was responsible for the hypouricemia and also for the rare side-effect of an uric acid nephropathy in this patient.
Erley
C M
CM
St. Joseph-Krankenhaus I, Medizinische Abteilung II, Berlin.
Hirschberg
R R
RR
Hoefer
W
W
Schaefer
K
K
D058186:Acute Kidney Injury / Q000473:pathology*; D000328:Adult; D003404:Creatinine / Q000097:blood; D006801:Humans; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D009395:Nephritis, Interstitial / Q000473:pathology; D006435:Renal Dialysis; D014527:Uric Acid / Q000378:metabolism*
D014527:Uric Acid; D003404:Creatinine