[Enhanced inhibition of splenic lymphocyte proliferation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57B1/10 (Ah+Ah+) mice compared to DBA/2 (AhAh) mice].
In concanavalin A-treated cultures TCDD (10(-8)M) inhibited proliferation of mouse spleen lymphocytes in cells of C57B1/10/mice by 65% and in cells of DBA/2 mice--by 42%. In phytohaemagglutinin-treated cultures of spleen lymphocytes of both strains TCDD produced no significant decrease in incorporation of 3H-thymidine into DNA. These observations indicate that effects of TCDD on lymphocyte proliferation are mediated by pleiotropic activity of Ah gene.
Pavliak
A L
AL
Wielgosz
S M
SM
Hüttner
E
E
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D003864:Depression, Chemical; D004147:Dioxins / Q000494:pharmacology*; D005796:Genes / Q000187:drug effects*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D008811:Mice, Inbred DBA / Q000235:genetics*; D010835:Phytohemagglutinins / Q000494:pharmacology; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects*
D004147:Dioxins; D010835:Phytohemagglutinins; D000072317:Polychlorinated Dibenzodioxins; D003208:Concanavalin A
Povyshennoe tormozhenie proliferatsii limfotsitov selezenki 2,3,7,8-tetrakhlorodibenzo-p-dioksinom u mysheĭ linii C57B1/10 (Ah+Ah+) po sravneniiu s myshami linii DBA/2 (AhAh).