title: The brain-specific gene for rat aldolase C possesses an unusual housekeeping-type promoter.
abstract: A DNA fragment encompassing the first exon and about 750 bp of the 5'-flanking sequence has been isolated and sequenced. The gene has multiple start sites of transcription which are dispersed over about 200 bp. The promoter lacks TATA and CAAT boxes and is very G + C-rich, with putative binding sites for the transcriptional factors Sp1 and AP2. Similar features are shared with two other brain-specific genes encoding thy-1 antigen and gamma-enolase. The existence of a conserved block of similarity upstream of the human and rat aldolase C genes suggests that this region could be involved in tissue-specific expression whose mechanism seem to be, at least in part, transcriptional.
authors.affiliation: Institute de Recherches en Génétique et Pathologie Moléculaires, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Vibert
authors.forename: J
authors.initials: J
authors.lastname: Henry
authors.forename: A
authors.initials: A
authors.lastname: Kahn
authors.forename: H
authors.initials: H
authors.lastname: Skala
mesh_terms: D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000201:enzymology*; D003001:Cloning, Molecular; D005091:Exons; D005634:Fructose-Bisphosphate Aldolase / Q000235:genetics*; D005796:Genes; D007527:Isoenzymes / Q000235:genetics*; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D051381:Rats; D015183:Restriction Mapping
chemical_list: D007527:Isoenzymes; D005634:Fructose-Bisphosphate Aldolase