[The role of glycosaminoglycans in regulation of medullary hematopoiesis in stress].
The role of the constituents of hematopoiesis inducing bone marrow microenvironment in myelopoiesis regulation was studied. It was found that during the development of the general adaptation syndrome the functional activity of stroma cells and granulomonocytopoiesis precursor cells intensifies and the content of acid glycosaminoglycans in the bone marrow increases. It is shown that acid glycosaminoglycans produce an effect on the myelokaryocytes in intimate interrelationship with the prostaglandin system, changing the level of intracellular calcium and cAMP in the hematopoietic cells.
Dygaĭ
A M
AM
Shakhov
V P
VP
Iushkov
B G
BG
Makeev
O G
OG
Ivasenko
I N
IN
D000818:Animals; D006025:Glycosaminoglycans / Q000378:metabolism / Q000502:physiology*; D006410:Hematopoiesis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013315:Stress, Psychological / Q000503:physiopathology*
D006025:Glycosaminoglycans
Rol' glikozaminoglikanov v reguliatsii kostnomozgovogo krovetvoreniia pri stresse.