Hepatoprotective activity of silymarin against hepatic damage in Mastomys natalensis infected with Plasmodium berghei.
Silymarin, a flavolignan from the seeds of Silybum marianum, showed significant hepatoprotective activity in P. berghei-induced hepatic damage in M. natalensis, as assessed by changes in several serum and liver biochemical parameters. Changes in lipoprotein-X, GOT, GPT, alkaline phosphatase and bilirubin were found to be protected by silymarin at different doses. Maximum activity was observed at a dose of 5 mg/kg bw, po. Silymarin had no effect on parasitaemia.
Chander
R
R
Kapoor
N K
NK
Dhawan
B N
BN
D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000627:therapeutic use*; D006520:Hepatitis, Animal / Q000517:prevention & control*; D008111:Liver Function Tests; D008288:Malaria / Q000473:pathology*; D008297:Male; D009115:Muridae; D010962:Plasmodium berghei; D012838:Silymarin / Q000627:therapeutic use*
D005419:Flavonoids; D012838:Silymarin