Assignment of the feline alpha-L-iduronidase gene to chromosome D4.
The structural gene encoding feline alpha-L-iduronidase has been assigned to chromosome D4 by electrophoretic analysis of feline-hamster somatic cell hybrids. Previously, the human alpha-L-iduronidase gene had been assigned to the chromosomal region 22pter-q11. alpha-L-Iduronidase is the first human gene on chromosome 22 to be comparatively mapped in cats and the localization of the feline gene should facilitate further genetic analysis of the feline MPS I animal model.
Schuchman
E H
EH
Division of Medical and Molecular Genetics, Mount Sinai School of Medicine, New York, New York 10029.
O'Brien
S J
SJ
Desnick
R J
RJ
D000818:Animals; D002415:Cats / Q000235:genetics*; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D005796:Genes; D006026:Glycoside Hydrolases / Q000235:genetics*; D006822:Hybrid Cells; D007068:Iduronidase / Q000235:genetics*
D006026:Glycoside Hydrolases; D007068:Iduronidase