Resolution of apparent growth hormone-dependent growth failure during puberty: a case report.
A prepubertal boy with apparent growth hormone (GH)-dependent growth failure displayed a marked increase in growth velocity, normal GH responses to arginine/insulin infusion and a fourfold increase in spontaneous 24-hour GH secretion following the onset of normal puberty. The case supports earlier observations of a transient form of GH insufficiency in some short prepubertal children, but represents the first evidence that puberty restores spontaneous as well as stimulated GH secretion in such patients.
Weissberger
A J
AJ
Garvan Institute of Medical Research, St Vincent's Hospital, Sydney, Australia.
Ho
K Y
KY
Lazarus
L
L
D000293:Adolescent; D001120:Arginine / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D006130:Growth Disorders / Q000503:physiopathology*; D013006:Growth Hormone / Q000097:blood / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000494:pharmacology; D008297:Male; D011627:Puberty / Q000502:physiology*; D011863:Radioimmunoassay
D001786:Blood Glucose; D007328:Insulin; D013006:Growth Hormone; D001120:Arginine