[Correlation of changes in compound action potential (CAP) tuning curves and cochlear lesion in guinea pigs after explosion].
The purpose of the present study was to investigate the sensitivity of compound action potential (CAP) tuning curves to changes of the cochlear status in guinea pigs after explosion and their ability to reflect specific histological variations. The results were as follows: 1. The CAP tuning curves were abnormally broad and the Q 10 dB values were reduced by a factor of 1 after explosion, indicating wider tuning. 2. The degree of broadening of the CAP tuning curves seemed to increase as the hair cell loss increased. 3. After explosion, the tip of the tuning curve shifted to frequencies significantly higher or lower than that of the signal, it might be related to the location of hair cell loss in the cochlea. 4. In animals for which damage was restricted to only three rows of outer hair cells, changes of the CAP tuning curves were observed. It provides further evidence that the tuning properties of cochlear nerve fibers are dependent upon the integrity of the outer hair cells even though the great majority of fibers innervate inner hair cells only.
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D000818:Animals; D003051:Cochlea / Q000293:injuries* / Q000503:physiopathology; D003055:Cochlear Microphonic Potentials; D004594:Electrophysiology; D005107:Explosions; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000503:physiopathology; D008297:Male