title: Changes in the regional brain histamine and histidine levels in postmortem brains of Alzheimer patients.
abstract: In postmortem brains of Alzheimer patients, statistically significant decreases in histamine levels were observed in the frontal (45%), temporal (20%), and occipital cortices (38%) and in the caudate nucleus (25%). Histidine levels were decreased in the frontal (15%), temporal (21%), and occipital cortices (30%) and in the caudate nucleus (25%); the decrease was statistically significant in the last two brain regions. Histamine was determined by the double isotope technique, and histidine was determined fluorometrically by a fluorescamine method. The data indicate that brain histamine regulation is altered in Alzheimer's disease.
authors.affiliation: Department of Pharmacology, Faculty of Health Sciences, University of Ottawa, Ont., Canada.
authors.forename: I M
authors.initials: IM
authors.lastname: Mazurkiewicz-Kwilecki
authors.forename: S
authors.initials: S
authors.lastname: Nsonwah
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D001923:Brain Chemistry; D005260:Female; D006632:Histamine / Q000032:analysis*; D006639:Histidine / Q000032:analysis*; D006801:Humans; D008297:Male
chemical_list: D006639:Histidine; D006632:Histamine