title: Painless versus painful myocardial ischemia: different left ventricular dysfunction detected by echocardiography.
abstract: The mechanism responsible for the absence of anginal pain in patients who have episodes of both painless and painful myocardial ischemia, still remains unknown. Does the pain depend on an overstimulation of receptive structures or is this symptom the product of the excitation of a well-defined receptive system? The aim of this work is to test the first hypothesis: whether silent attacks are accompanied by the same degree of mechanical impairment as symptomatic ones. The authors compared the echocardiographic left ventricular functional behavior in the same patient (6 patients) during painful and painless myocardial ischemia. The echocardiographic changes observed during silent ischemic attacks were significantly different from those detected during symptomatic attacks. The latter were characterized by a larger extension of the ischemic myocardium and, as a consequence, by a larger functional impairment. Symptomatic and asymptomatic ischemic attacks were recorded echocardiographically in the same patient during repeated attacks on the same day, and were always clearly differentiated by the degree of wall motion abnormalities. The echocardiographic monitoring during the ischemic attack seemed to confirm that the greater functional impairment preceded the onset of pain leading to the occurrence of this symptom. Nevertheless, it was impossible to identify a threshold value above which the ischemic attack will be symptomatic. Our data seem to indicate a close relationship between painful ischemia and a higher degree of ischemic damage. Thus, in patients with predominantly painful myocardial ischemia, the extension and the severity of ischemia could play an important role in determining this symptom.
authors.affiliation: 1st Department of Cardiology, University La Sapienza, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Agati
authors.forename: M
authors.initials: M
authors.lastname: Penco
authors.forename: S
authors.initials: S
authors.lastname: Sciomer
authors.forename: F
authors.initials: F
authors.lastname: Fedele
authors.forename: C P
authors.initials: CP
authors.lastname: Neja
authors.forename: A
authors.initials: A
authors.lastname: Dagianti
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000209:etiology / Q000503:physiopathology*; D003327:Coronary Disease / Q000473:pathology / Q000503:physiopathology*; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000523:psychology