title: What's new in steroid receptor immunocytochemistry in clinical oncology?
abstract: In this review we outline the many practical advantages of immunocytochemistry for estrogen receptors (ER) and the staining intensity index for its interpretation. We discuss the heterogenous distribution of ER in malignant and non-malignant breast tissue and the correlation of ER staining with pathologic features. In predicting the response of breast cancer to endocrine therapy, we conclude that both fine needle aspirates and tissue sections are adequate for the assessment of ER.
authors.affiliation: Department of Clinical Oncology, St. Georges Medical School, London, England.
authors.forename: D
authors.initials: D
authors.lastname: Ricketts
authors.forename: R C
authors.initials: RC
authors.lastname: Coombes
mesh_terms: D001940:Breast / Q000648:ultrastructure; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D011987:Receptors, Steroid / Q000378:metabolism*
chemical_list: D011987:Receptors, Steroid