Electrophysiological effects of the new antiarrhythmic drug 3-(diisopropylaminoethylamino)-2',6'-dimethylpropionanilide++ + on dog cardiac muscle.
The effects of 3-(diisopropylaminoethylamino)-2',6'-dimethylpropionanilide (AN-132), a new antiarrhythmic drug, on the electrical activities of dog ventricular muscles and Purkinje fibers were studied using standard microelectrode techniques. In ventricular muscles, AN-132 (10(-5)-10(-4) mol/l) decreased the overshoot potential and the maximum rate of rise of the action potential without changing the resting membrane potential, the plateau potential and the action potential duration at a driving rate of 0.5 Hz. These results indicate that AN-132 belongs to class 1 antiarrhythmic drugs. Lidocaine (10(-6)-10(-4) mol/l) failed to affect these parameters under the same conditions. In Purkinje fibers, both drugs decreased the plateau potential and shortened the action potential duration. To subclassify AN-132 among class 1 antiarrhythmic drugs, the kinetics of onset of rate-dependent effect of AN-132 (10(-4) mol/l) was compared with that of lidocaine (10(-4) mol/l), and AN-132 was found to have the slower onset kinetics than lidocaine.
Sato
Y
Y
Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
Iijima
T
T
Taira
N
N
D000200:Action Potentials / Q000187:drug effects; D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D004285:Dogs; D005029:Ethylenediamines / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D011690:Purkinje Fibers / Q000187:drug effects
C053205:3-(diisopropylaminoethylamino)-2',6'-dimethylpropionanilide, diphosphoric acid; D000813:Anilides; D000889:Anti-Arrhythmia Agents; D005029:Ethylenediamines; D008012:Lidocaine