title: Dendritic cell ontogeny.
abstract: Abundant evidence indicates that dendritic cells arise from the bone marrow. In vitro, precursors that differ phenotypically from mature dendritic cells divide several times to form functional dendritic cells. A soluble factor(s) produced in the supernatants of ConA-stimulated spleen cells enhances the production of dendritic cells. This factor(s) has not been fully characterized. Further maturation of dendritic cells occurs after they are released from the bone marrow; species differences exist. Interrelationships between various types of dendritic cells need to be elucidated.
authors.affiliation: Medical Research Institute, Mary Imogene Bassett Hospital, Cooperstown, New York 13326.
authors.forename: W E
authors.initials: WE
authors.lastname: Bowers
authors.forename: E M
authors.initials: EM
authors.lastname: Goodell
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology