title: [Reduction of A. actinomycetemcomitans in the subgingival microflora of adult advanced periodontitis].
abstract: In 15 adult patients with severely advanced periodontal disease unrelated to localized juvenile periodontitis high numbers of A. actinomycetemcomitans (A. a.) were identified in samples of subgingival plaque (median log CFU 5.13). In order to correlate clinical conditions with bacteriological findings, in every patient 2 deep periodontal pockets were treated with a 3-phase regimen of minocycline administration, mechanical, and surgical periodontal therapy. A. a. was eliminated by minocycline alone in 2 cases. Minocycline in combination with subgingival scaling resulted in 6 patients in A. a. negative samples. Following termination of minocycline therapy, frequently increasing numbers of A. a. were observed. Patients showed significant gain in clinical attachment or reduction of probing pocket depth during different phases of therapy, but only if A. a. was suppressed close to or below the lower limit of detection (5 CFU/ml). Considerable problems with elimination of A.a. may be connected with frequently observed recurrent periodontal disease in these patients.
authors.forename: H P
authors.initials: HP
authors.lastname: Müller
authors.forename: R F
authors.initials: RF
authors.lastname: Müller
authors.forename: D E
authors.initials: DE
authors.lastname: Lange
mesh_terms: D000188:Actinobacillus / Q000187:drug effects*; D000328:Adult; D015169:Colony Count, Microbial; D003773:Dental Plaque / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D008911:Minocycline / Q000627:therapeutic use*; D010510:Periodontal Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D012008:Recurrence
chemical_list: D008911:Minocycline
vernacular_title: Die Reduktion von A. actinomycetemcomitans bei der profunden Parodontitis.