Age and blood cell rheology.
The identification of the rheological variables responsible for alterations in capillary blood flow caused by the aging process could help explain why the incidence of vascular disease increases with age. Using new techniques for the separation and micropore filtration of the haemocellular subpopulations in 110 subjects aged 21-84 years, the aim of this study was to show to what extent, if any, age influences blood cell deformability. The filterability of mononuclear leucocytes decreased with age (r = 0.25; p less than 0.001), whereas the filterability of polymorphonuclear leucocytes or erythrocytes did not change significantly with age.
Ciuffetti
G
G
2nd Department of Internal Medicine, Faculty of Medicine, University of Perugia, Italy.
Mercuri
M
M
Rizzo
M T
MT
Lennie
S E
SE
Lowe
G D
GD
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D004907:Erythrocyte Deformability; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology; D012212:Rheology