Bioequivalence (bioavailability) of generic topical corticosteroids.
A new, quantitative modification of the vasoconstrictor assay was used to measure bioavailability of generic topical corticosteroid products in two categories: betamethasone valerate 0.1% cream and triamcinolone 0.1% cream. Betamethasone valerate products could be separated into two distinct categories, and triamcinolone acetonide products could be grouped into three categories of activity. A survey of local pharmacies showed that generic substitution would be made for the prescribed brand of betamethasone valerate in 58% of cases and for the prescribed triamcinolone acetonide 75% of the time. Because of the prevalence of generic substitution of products that may not have equivalent bioavailability, some standardization of the bioavailability of topical products is needed.
Jackson
D B
DB
Department of Dermatology, College of Medicine, University of Arkansas for Medical Sciences.
Thompson
C
C
McCormack
J R
JR
Guin
J D
JD
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000493:pharmacokinetics* / Q000494:pharmacology; D001682:Biological Availability; D004311:Double-Blind Method; D006801:Humans; D010594:Pharmacies; D013810:Therapeutic Equivalency; D014661:Vasoconstriction / Q000187:drug effects
D000305:Adrenal Cortex Hormones