Monoclonal immunoglobulin gene rearrangement in peripheral lymphocytes of a patient with multiple myeloma.
We analyzed the immunoglobulin (Ig) heavy chain gene rearrangement in the peripheral blood lymphocytes of a patient with multiple myeloma (MM). Although the morphological and immunological examination did not reveal the presence of circulating plasma cells, a monoclonal Ig gene rearrangement was detected. This observation indicates that a monoclonal expansion of circulating B cells was present in the peripheral lymphocytes of this patient.
Palumbo
A P
AP
Department of Medicine and Experimental Oncology, University of Torino, Italy.
Pileri
A
A
Battaglio
S
S
Omedè
P
P
Redoglia
V
V
Massaia
M
M
Dianzani
U
U
Boccadoro
M
M
D004247:DNA / Q000032:analysis; D005260:Female; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics / Q000276:immunology*
D004247:DNA