Comparison of propofol with thiopental and isoflurane for induction and maintenance of general anesthesia.
Propofol, a phenol compound with a short elimination half-life, was compared with thiopental and isoflurane for induction and maintenance of general anesthesia in 60 consenting ASA I, II, and III patients. The study was randomized and open label in design. Hemodynamically, the propofol patients showed a mean +/- SEM decrease in systolic blood pressure in comparison with the thiopental/isoflurane group at 2 (115.1 +/- 4.9 vs. 136.6 +/- 6.0 mmHg), 3 (125.7 +/- 5.1 vs. 149.4 +/- 5.6 mmHg), and 5 min (126.6 +/- 3.8 vs. 144.4 +/- 6.1 mmHg) postinduction and at intubation (135.2 +/- 4.7 vs. 157.8 +/- 6.0 mmHg) (p less than 0.05). The heart rate was lower in the propofol group throughout the induction period (p less than 0.05). Patients who received propofol were ready for discharge from the recovery room sooner (67.9 +/- 4.0 vs. 80.0 +/- 3.6 min) than the thiopental/isoflurane-treated patients (p less than 0.05). Propofol is as safe and effective for induction and maintenance of general anesthesia as thiopental and isoflurane.
Gold
M I
MI
Department of Anesthesiology, Veterans Administration Medical Center, Miami, FL 33125.
Sacks
D J
DJ
Grosnoff
D B
DB
Herrington
C A
CA
D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D004311:Double-Blind Method; D006439:Hemodynamics; D006801:Humans; D007530:Isoflurane; D008875:Middle Aged; D015742:Propofol; D016032:Randomized Controlled Trials as Topic; D013874:Thiopental
D007530:Isoflurane; D013874:Thiopental; D015742:Propofol