title: Some considerations of receptor specificity.
abstract: Since the amino acid sequences for several muscarinic and adrenergic receptors are known, an attempt was made to correlate side chain hydrophobicity surrounding the aspartate anionic groups with binding structure-activity relationships. No positive correlation was found, suggesting that secondary binding effects of head group substituents are non-local. Displacement of aspartate ionization is unlikely to be due to such neighbour effects.
authors.forename: A S
authors.initials: AS
authors.lastname: Burgen
mesh_terms: D000818:Animals; D006801:Humans; D011487:Protein Conformation; D011976:Receptors, Muscarinic / Q000187:drug effects*
chemical_list: D011976:Receptors, Muscarinic