Pharmacokinetics of prednisolone in children with acute lymphoblastic leukaemia.
The pharmacokinetics of soluble oral prednisolone were studied during induction therapy in six children with acute lymphoblastic leukaemia. There was a three- to four-fold variation in the pharmacokinetics of total and free prednisolone. For total prednisolone, the mean elimination half-life was relatively short (1.37 h) and the total clearance, relatively high (15.1 ml min-1 kg-1). The mean free fraction was high (0.37).
Choonara
I
I
Department of Paediatrics and Child Health, St. Jame's University Hospital, Leeds, U.K.
Wheeldon
J
J
Rayner
P
P
Blackburn
M
M
Lewis
I
I
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000188:drug therapy; D011239:Prednisolone / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011241:Prednisone / Q000008:administration & dosage
D011239:Prednisolone; D011241:Prednisone