[Antibiotic prophylaxis in major surgery of the neck and head].
Twenty-two patients undergoing major head and neck surgery were included in a randomized trial to value the efficacy and side effects of parenteral short-term antibiotic prophylaxis of post-operative infections. Two different antibiotic regimens were compared: group A, ceftazidime i.v. (2 g) in three doses (half an hour before surgery, 8 and 16 hours, from the first dose); group B, netilmicin (100 mg) plus clindamycin (600 mg i.v.), following the same chronological schedule. Overall infection rate was 18% (4/22): all post-operative infections occurred in group A patients, including one case of wound infection and 3 mixed infections (wound infection associated with lung infection), with a significant reduction of post-operative infection rate in group B patients (p = 0.045; Fisher's exact test).
Margarino
G
G
Scala
M
M
Gipponi
M
M
Mereu
P
P
Amoretti
G
G
Cafiero
F
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000517:prevention & control; D002442:Ceftazidime / Q000627:therapeutic use*; D002981:Clindamycin / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009428:Netilmicin / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication
D002981:Clindamycin; D009428:Netilmicin; D002442:Ceftazidime
Profilassi antibiotica nella chirurgia maggiore del distretto cervico-cefalico.