[Mechanism of the action of the delta sleep-inducing peptide against a background of L-DOPA administration].
A reciprocal nature of the shifts in activity of type A and B monoamine oxidases has been observed under the effect of DSIP against the background of L-DOPA administration (50 micrograms/kg) in the subfractions from the rabbit sensorimotor cortex. The results suggest that the activation of type A monoamine oxidase and serotoninergic system is the basis of the adaptive behavior of animals.
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D000110:Acetylcholinesterase / Q000378:metabolism; D000374:Aggression / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001007:Anxiety / Q000503:physiopathology; D002421:Caudate Nucleus / Q000187:drug effects / Q000201:enzymology; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D007980:Levodopa / Q000494:pharmacology*; D008995:Monoamine Oxidase / Q000378:metabolism; D009044:Motor Cortex / Q000187:drug effects / Q000201:enzymology; D010627:Phenethylamines / Q000378:metabolism; D011817:Rabbits; D012701:Serotonin / Q000378:metabolism; D013379:Substrate Specificity / Q000187:drug effects
D010627:Phenethylamines; C044350:4-nitrophenethylamine; D012701:Serotonin; D007980:Levodopa; D003701:Delta Sleep-Inducing Peptide; D008995:Monoamine Oxidase; D000110:Acetylcholinesterase
K mekhanizmu deĭstviia peptida del'ta-sna na fone vvedeniia L-DOFA.