[Individual differences in PCA response in the guinea pig].
Experiments were carried out to determine the cause of individual differences in the passive cutaneous anaphylaxis (PCA) response in guinea pigs. The intensity of 4-h homologous PCA produced by anti-penicillin G serum was not markedly different among eight reactive sites on the back of a specified animal, whereas considerable individual differences were observed in the PCA response, even at a specified reactive site. PCA was significantly inhibited by an antihistaminic agent, promethazine, and the tissue histamine content was significantly reduced after PCA, suggesting histamine release as a mediator. The intensity of PCA in individual animals was highly correlated with that of the histamine-induced cutaneous reaction elicited at a site adjoining the PCA but was unrelated to skin histamine content. These results suggest that the difference in susceptibility to histamine has a considerable effect on individual differences in the PCA response in guinea pigs.
Yoshida
J
J
Kyoto Research Laboratories, Kaken Pharmaceutical Co. Ltd., Japan.
Kuriyama
K
K
Nagatahira
R
R
Kubo
K
K
Yoshinaka
I
I
D000818:Animals; D006168:Guinea Pigs / Q000276:immunology*; D006632:Histamine / Q000276:immunology / Q000378:metabolism; D007106:Immune Sera / Q000276:immunology; D008297:Male; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D010400:Penicillin G / Q000276:immunology; D011398:Promethazine / Q000494:pharmacology; D012867:Skin / Q000276:immunology / Q000378:metabolism
D007106:Immune Sera; D006632:Histamine; D011398:Promethazine; D010400:Penicillin G