Monooxygenation of N-acetylhistamine mediated by L-ascorbate.
In the presence of molecular oxygen and a catalytic amount of copper(II) ion, ascorbate almost completely degraded histamine (approx. 72%). The reaction was shown to occur at the imidazole group but not at the primary amino group in histamine. 4-[2-(Acetylamino)ethyl]-2,3-dihydroimidazol-2-one, a monooxygenated form of N-acetylhistamine, was first isolated as the primary product.
Uchida
K
K
Department of Food Science and Technology, Nagoya University, Japan.
Mitsui
M
M
Kawakishi
S
S
D001205:Ascorbic Acid; D002851:Chromatography, High Pressure Liquid; D006632:Histamine / Q000031:analogs & derivatives*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction
C021606:N-acetylhistamine; D006632:Histamine; D001205:Ascorbic Acid