title: [Sensitivity of Plasmodium falciparum to different antimalarials. A study in 1988 in a village in the Hauts-Plateaux of Madagascar].
abstract: Since a few years, malaria has reappeared in the Central Highland Plateaux of Madagascar. From 1983 to 1987, Plasmodium falciparum resistance to chloroquine remained stable, with a low frequency of R2 therapeutic failures. In 1988, a study was conducted in the village of Manarintsoa, 15 km from Tananarive. Ninety-one WHO in vivo standard tests were performed. In vitro efficacy of amodiaquine and quinine was also studied. In vitro, the efficacy of chloroquine, quinine, and mefloquine was measured against 104, 64, and 23 P. falciparum isolates, respectively, by an isotopic semi-microtest.
authors.affiliation: Institut Pasteur de Madagascar, Tananarive.
authors.forename: J P
authors.initials: JP
authors.lastname: Lepers
authors.forename: P
authors.initials: P
authors.lastname: Deloron
authors.forename: M D
authors.initials: MD
authors.lastname: Andriamangatiana-Rason
authors.forename: J A
authors.initials: JA
authors.lastname: Ramanamirija
authors.forename: P
authors.initials: P
authors.lastname: Coulanges
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D006801:Humans; D008270:Madagascar; D015767:Mefloquine / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D011803:Quinine; D015767:Mefloquine
vernacular_title: Sensibilité de Plasmodium falciparum à divers antimalariques. Etude en 1988 dans un village des Hauts-Plateaux malgaches.