Trichothiodystrophy and the relationship between DNA repair and cancer.
The identification of cellular deficiencies in the ability to repair damage in DNA in individuals with several cancer-prone genetic disorders, has led to the idea that defective DNA repair results in cancer. In patients with trichothiodystrophy, however, a recently discovered defect in the repair of ultraviolet damage in DNA is not associated with cancer-proneness. Thus our previous ideas about the connections between DNA repair capacity and cancer susceptibility need to be reevaluated.
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D002648:Child; D003057:Cockayne Syndrome / Q000150:complications / Q000235:genetics; D004260:DNA Repair; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006201:Hair Diseases / Q000150:complications / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000209:etiology / Q000235:genetics*; D014983:Xeroderma Pigmentosum / Q000150:complications / Q000235:genetics