[Peripheral cholinolytic action--one of the effects of sidnofen].
Intravenous bolus injection of sydnophen (0.002-20 micrograms/kg) resulted in decrease or complete abolition of bradycardia induced by electrical stimulation of vagal peripheral end of anesthetized cats. The cholinolytic effects are dose-dependent. The small dose of sydnophen (0.002 micrograms/kg) which wasn't able to cause any alteration of EEG, heart rate and arterial pressure induced decrease of vagal bradycardia.
Samonina
G E
GE
Mandriko
E V
EV
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004562:Electrocardiography; D004569:Electroencephalography; D006339:Heart Rate / Q000187:drug effects; D010069:Oxadiazoles / Q000494:pharmacology*; D010275:Parasympathetic Nervous System / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D013558:Sydnones / Q000494:pharmacology*; D014630:Vagus Nerve / Q000502:physiology
D010069:Oxadiazoles; D010276:Parasympatholytics; D013558:Sydnones; C013271:sydnophen
Perifericheskoe kholinoliticheskoe deĭstvie--odin iz éffektov sidnofena.