Cytoskeletal rearrangement by oxidative stress.
The cytoskeleton is susceptible to oxidative stress and this occurs prior to membrane blebbing and cell lysis. Vimentin intermediary filaments in rheumatoid synoviocytes are more susceptible than in normal synoviocytes and this may have pathological significance. They are however no more susceptible to heat shock than other cell types.
Rogers
K R
KR
London Hospital Medical College, England.
Morris
C J
CJ
Blake
D R
DR
D002478:Cells, Cultured; D003599:Cytoskeleton / Q000187:drug effects* / Q000648:ultrastructure; D004591:Electrophoresis, Polyacrylamide Gel; D005455:Fluorescent Antibody Technique; D006358:Hot Temperature; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity*; D010084:Oxidation-Reduction; D014746:Vimentin / Q000032:analysis
D014746:Vimentin; D006861:Hydrogen Peroxide