[Antimalarial serology in 1987-1988 in the Highland Plateaux, the East coast and the South of Madagascar].
We studied 521 serum samples collected in 1987-88 in the Highland Plateaux and the East coast of Madagascar, two areas presenting different levels of malaria endemicity. Total anti-Plasmodium falciparum antibodies were investigated by an indirect immunofluorescence assay (IFA). Antibodies directed to the ring-infected erythrocyte surface antigen (RESA) were investigated by a modified IFA (MIFA). Results were analysed in regards to malariological parameters (parasite and splenomegaly rates) collected simultaneously. IFA appears as a good epidemiological tool as it closely parallels the classical malariological parameters. In selected studies, the presence of P. falciparum parasites in blood was less frequent in individuals presenting with anti-RESA antibody, as detected by MIFA, than in the other individuals were consistently lower in subjects with anti-RESA antibody than in others.
Andriamangatiana-Rason
M D
MD
Unité de Recherche sur le Paludisme, Institut Pasteur de Madagascar.
Lepers
J P
JP
Deloron
P
P
Coulanges
P
P
D000818:Animals; D000913:Antibodies, Protozoan / Q000302:isolation & purification*; D000953:Antigens, Protozoan / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D002648:Child; D005455:Fluorescent Antibody Technique; D006801:Humans; D008270:Madagascar / Q000453:epidemiology; D008288:Malaria / Q000453:epidemiology / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D000954:Antigens, Surface; D015800:Protozoan Proteins; C050256:ring-infected erythrocyte surface antigen (RESA), Plasmodium falciparum
Sérologies antipalustres en 1987-1988 sur les Hauts Plateaux, la côte Est et le Sud de Madagascar.