Development and optimisation of a high-performance liquid chromatographic assay for tioconazole and its potential impurities. Part II. Selection of detection conditions for potential impurities.
An optimised high-performance liquid chromatographic separation developed for the assay of tioconazole and its potential impurities has been applied to real-world samples where tioconazole is in excess. As severe peak tailing interferes with the assay of two of the impurity peaks, changes in detection wavelength have been examined as a means to discriminate between this interference. The resulting enhancement of resolution has been exploited in the optimisation of analysis time.
Wright
A G
AG
Berridge
J C
JC
Fell
A F
AF
D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D007093:Imidazoles / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
D007093:Imidazoles; C020527:tioconazole