title: Regularly alternating L,D-peptides. III. Hexacyclic peptides from valine or phenylalanine.
abstract: In the present paper we describe the single-crystal x-ray analyses of two cyclic hexapeptides containing an equal number of alternating L,D-residues as putative analogues of the metal binding compounds, enniatin and beauvericine. Both the molecules of c(L-Val-D-Val)3 and C(L-Phe-D-Phe)3 retain in the solid state the center of symmetry and crystallize with six and eight trifluoroacetic acid molecules, respectively. The peptides are strongly hydrogen bonded to the solvent molecules. We estimate, on the basis of the molecular geometry and spatial arrangement of the peptide carbonyl groups and in comparison with other metal binding cyclic peptides, the ability of these molecules to interact with metal ions as 1:1 complexes.
authors.forename: V
authors.initials: V
authors.lastname: Pavone
authors.forename: E
authors.initials: E
authors.lastname: Benedetti
authors.forename: B
authors.initials: B
authors.lastname: Di Blasio
authors.forename: A
authors.initials: A
authors.lastname: Lombardi
authors.forename: C
authors.initials: C
authors.lastname: Pedone
authors.forename: L
authors.initials: L
authors.lastname: Tomasich
authors.forename: G P
authors.initials: GP
authors.lastname: Lorenzi
mesh_terms: D007536:Isomerism; D009842:Oligopeptides; D010456:Peptides, Cyclic; D010649:Phenylalanine; D011487:Protein Conformation; D014633:Valine; D014961:X-Ray Diffraction
chemical_list: D009842:Oligopeptides; D010456:Peptides, Cyclic; D010649:Phenylalanine; D014633:Valine