title: Pharmacokinetics of intraperitoneal ciprofloxacin in patients on CAPD.
abstract: The concentration of ciprofloxacin was assayed in plasma and peritoneal dialysate following intraperitoneal administration of the drug in the absence of bacterial peritonitis. After administration of a single dose of 5 mg/kg, ciprofloxacin was rapidly absorbed, producing a peak plasma concentration of 1.9 +/- 0.6 mg/l after 3-4 h with an apparent bioavailability of 0.84. In a separate study, following the administration of 25 mg/l for eight consecutive CAPD cycles the intraperitoneal concentration of ciprofloxacin fell to a mean of 8.4 +/- 4.6 mg/l after 4 h cycles and to a mean of 3.0 +/- 3.2 mg/l after 12 h cycles. During the period of administration the mean plasma concentration was 0.5 +/- 0.2 mg/l. Analysis of dialysate for 48 h after cessation of drug administration demonstrated ciprofloxacin to be present in effluent from only two of the six patients, confirming its poor peritoneal elimination.
authors.affiliation: Department of Renal Medicine, University of Wales College of Medicine, Cardiff, UK.
authors.forename: D
authors.initials: D
authors.lastname: Dharmasena
authors.forename: D E
authors.initials: DE
authors.lastname: Roberts
authors.forename: G A
authors.initials: GA
authors.lastname: Coles
authors.forename: J D
authors.initials: JD
authors.lastname: Williams
mesh_terms: D002939:Ciprofloxacin / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007263:Infusions, Parenteral; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010538:Peritonitis / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D002939:Ciprofloxacin