[Potassium cyanate modification of the toxic and mutagenic effects of gamma radiation and benzo(a)pyrene].
In experiments with CHO-AT3-2 cell culture, a study was made of the effect of potassium cyanate (KNCO) on the effect of gamma radiation and benzo(a)pyrene (BP) by the following tests: cell viability, induction of cells with micronuclei and fragmented nuclei and mutations by thymidine kinase (TK) and Na+/K+-ATPase loci. Some tests have revealed the increase in the effect of gamma radiation and BP produced by potassium cyanate. It is suggested that the sensitizing effects are related to repair system inhibition and/or changes in the cell chromatin structure produced by KNCO.
Serebrianyĭ
A M
AM
Sal'nikova
L E
LE
Bakhitova
L M
LM
Pashin
Iu B
IuB
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D003485:Cyanates / Q000494:pharmacology*; D004347:Drug Interactions; D004357:Drug Synergism; D005720:Gamma Rays / Q000009:adverse effects; D015162:Micronucleus Tests; D009154:Mutation; D011830:Radiation Effects
D003485:Cyanates; D001564:Benzo(a)pyrene; C024835:potassium cyanate
Modifikatsiia tsianatom kaliia toksicheskikh i mutagennykh éffektov gamma-izlucheniia i benzo(a)pirena.