title: [In vitro susceptibility of pathogenic Nocardia to beta-lactam antibiotics, especially imipenem, a carbapenem antibiotic].
abstract: In vitro antibacterial activity of 30 beta-lactam antibiotics including 2 beta-lactamase inhibitors (clavulanic acid and sulbactam) against 2 major pathogenic Nocardia, i.e. Nocardia asteroides group and Nocardia brasiliensis was studied. Among the antibiotics tested, a newly developed carbapenem antibiotic, imipenem (IPM), was found to be the most active, followed by oxacephem group antibiotic flomoxef (FMOX). IPM exhibited activity against only N. asteroides group (N. asteroides, Nocardia farcinica and Nocardia nova). On the other hand, FMOX showed activity against all pathogenic Nocardia tested. A 2- to 30-fold decreases in minimum inhibitory concentration (MIC) for N. asteroides, N. brasiliensis and N. farcinica was noted when antibiotics and beta-lactamase inhibitors were combined compared to antibiotics alone. Further combination and enzymatic studies indicated that all pathogenic Nocardia possess beta-lactamase except for a half of the strains of N. nova. These species' specific sensitivity patterns of pathogenic Nocardia are discussed in this paper with references to their taxonomic positions.
authors.affiliation: Department of Experimental Chemotherapy, Research Center for Pathogenic Fungi.
authors.forename: K
authors.initials: K
authors.lastname: Yazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Mikami
authors.forename: K
authors.initials: K
authors.lastname: Otozai
authors.forename: J
authors.initials: J
authors.lastname: Uno
authors.forename: T
authors.initials: T
authors.lastname: Arai
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002969:Clavulanic Acids / Q000494:pharmacology; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000187:drug effects*; D009616:Nocardia asteroides / Q000187:drug effects; D013407:Sulbactam / Q000494:pharmacology; D065093:beta-Lactamase Inhibitors
chemical_list: D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D065093:beta-Lactamase Inhibitors; D015378:Imipenem; D013407:Sulbactam