[Pharmacokinetic and clinical studies of cefodizime in the field of obstetrics and gynecology].
Cefodizime (THR-221, CDZM), a new antibiotic, was studied pharmacokinetically and clinically. The results obtained are summarized as follows: 1. Concentrations of CDZM in internal genital tissues were quite high after an intravenous infusion. 2. Clinical effects of the therapy with CDZM using intravenous infusion twice daily were evaluated in 1 patient with endometritis, 2 patients with pyometra, 1 patient with extragenital abscess and 1 patient with BARTHOLIN'S gland abscess. Clinical responses were good in all 5 patients. No side effects nor abnormal laboratory test values due to the drug were noted.
Iioka
H
H
Department of Obstetrics and Gynecology, Nara Medical University.
Moriyama
I
I
Nabuchi
K
K
Katagami
Y
Y
Hisanaga
H
H
Tuji
Y
Y
Ichijo
M
M
D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy*; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004341:Drug Evaluation; D004361:Drug Tolerance; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy* / Q000378:metabolism; D005836:Genitalia, Female / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D014018:Tissue Distribution
D002439:Cefotaxime; C033356:cefodizime