title: [Preoperative irradiation, cisplatin sensitization and radical surgery of primarily operable carcinomas of the oral cavity. Results of a prospective DOSAK treatment study].
abstract: 165 patients with carcinomas of the oral cavity or oropharynx, clinically appearing operable, were treated between 1985 and 1987 within the framework of a prospective multicenter study. The treatment concept consisted in preoperative irradiation with 32 Gy, cisplatin sensitization with 5 X 20 mg per m2 body surface area and subsequent radical removal of the primary tumor and the regional cervical lymph nodes. Regarding recurrence and survival rates the patient data were analyzed using one- and multi-dimensional statistical methods. The observed survival rates were compared with those assessed with the aid of the treatment-dependent prognosis index TPI (Platz et al. 1982). After 1 years the survival rates under the selected combination therapy were 12% and after 2 years 19% above the assessed survival rates under radical surgery alone.
authors.forename: C
authors.initials: C
authors.lastname: Mohr
authors.forename: W
authors.initials: W
authors.lastname: Bohndorf
authors.forename: H
authors.initials: H
authors.lastname: Gremmel
authors.forename: H
authors.initials: H
authors.lastname: Härle
authors.forename: J E
authors.initials: JE
authors.lastname: Hausamen
authors.forename: H
authors.initials: H
authors.lastname: Hirche
authors.forename: M
authors.initials: M
authors.lastname: Molls
authors.forename: K H
authors.initials: KH
authors.lastname: Renner
authors.forename: J
authors.initials: J
authors.lastname: Reuther
authors.forename: H
authors.initials: H
authors.lastname: Sack
mesh_terms: D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D015337:Multicenter Studies as Topic; D010610:Pharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*
chemical_list: D002945:Cisplatin
vernacular_title: Pröperative Radiatio, Cisplatin-Sensibilisierung und radikale Resektion primär operabler Mundhöhlenkarzinome. Ergebnisse einer prospektiven Therapiestudie des DOSAK.