title: Colcemid effects on homologue pairing and crossing over during fetal mouse oogenesis.
abstract: Colcemid was administered to gestational day 13 female mice to test effects on homologue pairing, synapsis and recombination of fetal oogenesis. Pairing abnormalities were detected in pachytene oocytes by light and electron microscopy examination of bivalents and synaptonemal complexes. Reduction of total chiasmata per treated diplotene oocyte (22.74) compared to controls (31.07) was found.
authors.affiliation: Department of Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University, New York 10032.
authors.forename: G
authors.initials: G
authors.lastname: Jagiello
authors.forename: W K
authors.initials: WK
authors.lastname: Sung
authors.forename: J S
authors.initials: JS
authors.lastname: Fang
authors.forename: M B
authors.initials: MB
authors.lastname: Ducayen
mesh_terms: D000818:Animals; D003434:Crossing Over, Genetic / Q000187:drug effects*; D003703:Demecolcine / Q000494:pharmacology*; D005260:Female; D007621:Karyotyping; D008098:Litter Size / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D009865:Oocytes / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure; D009866:Oogenesis / Q000187:drug effects*; D011247:Pregnancy; D012016:Reference Values; D012744:Sex Ratio / Q000187:drug effects; D013573:Synaptonemal Complex / Q000187:drug effects
chemical_list: D003703:Demecolcine