Luminal adrenergic agents modulate intestinal transport.
Intestinal transport is controlled by luminal solutes, neural pathways, and paracrine or humoral agents. The current study investigated the effect of luminally administered adrenergic agents on the intestinal transport of water and electrolytes. Dogs with 25-cm jejunal Thiry-Vella loops were studied. The loops were luminally perfused with an isotonic solution containing [14C]PEG, and the fluxes of H2O, Na+, and Cl- were calculated. Each experiment consisted of three 1-hr periods: basal, luminal agent infusion, and recovery. Luminal adrenergic agents did not alter heart rate. Norepinephrine (alpha 1 greater than alpha 2 and beta adrenergic agonist) and phenylephrine (alpha 1 adrenergic agonist) caused significant absorption of water and sodium. Clonidine (alpha 2 adrenergic agonist) and isoproterenol (beta adrenergic agonist) caused significant secretion of water, sodium, and chloride. Luminally administered adrenergic agents can influence small intestinal water and electrolyte transport. Alpha 1 agonists have a proabsorptive effect, while alpha 2 and beta agonists have a secretory effect. Luminally administered proabsorptive adrenergic agents may prove useful in pathologic secretory states such as diabetic diarrhea, small bowel transplantation, or diarrhea-associated endocrinopathies.
Bastidas
J A
JA
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
Schmieg
R E
RE
Yeo
C J
CJ
Zinner
M J
MJ
D000818:Animals; D002712:Chlorides / Q000378:metabolism*; D003000:Clonidine / Q000494:pharmacology; D004285:Dogs; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism*; D013566:Sympathomimetics / Q000494:pharmacology*; D013997:Time Factors; D014867:Water / Q000378:metabolism*
D002712:Chlorides; D013566:Sympathomimetics; D014867:Water; D010656:Phenylephrine; D012964:Sodium; D007545:Isoproterenol; D003000:Clonidine; D009638:Norepinephrine