Renal denervation alters forebrain hexokinase activity in neurogenic hypertensive rats.
The effect of afferent renal nerve transection (tARN) on the metabolic activity of forebrain structures the activity of which was altered after aortic depressor nerve transection (tADN) was studied using the hexokinase (HK) histochemical method in the rat. In tADN-sham (s) ARN rats, increases in HK activity were observed in the medial septum (MS), median preoptic nucleus (MnPO), subfornical organ, supraoptic nucleus, nucleus circularis (Nc), magnocellular, and dorsal and medial (mpPVH) parvocellular components of paraventricular nucleus, the anterior, lateral, and dorsomedial (DMH) hypothalamus, and in the central and medial nuclei of the amygdala. In addition, a decrease in HK activity was seen in the dorsal arcuate nucleus (dArc). Similarly, increases in HK activity were seen in sADN-tARN rats in all the above structures except MS, Nc, and DMH, where no changes were observed, and dArc, where an increase in HK activity was noted. The bed nucleus of the stria terminalis, lateral preoptic nucleus (POA), and ventral (v) Arc also showed elevated HK activity. In contrast, the increased HK activity after either tADN or tARN alone was returned to levels not different from sADN-sARN rats in all structures in the tADN-tARN rats, except MnPO, mpPVH, and dArc, where the level of HK activity was only attenuated, and MS, POA, and vArc, where it remained elevated. These data suggest that similar forebrain structure are associated with the hypertension after tADN and are involved in the integration of ARN information and that these sites of interaction are involved in the maintenance and the reversal of the neurogenic hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)
Simon
J K
JK
Department of Physiology, University of Western Ontario, London, Canada.
Zhang
T X
TX
Ciriello
J
J
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000201:enzymology*; D003714:Denervation; D006593:Hexokinase / Q000378:metabolism*; D006973:Hypertension / Q000201:enzymology*; D007668:Kidney / Q000294:innervation*; D008297:Male; D011311:Pressoreceptors / Q000502:physiology; D051381:Rats; D012018:Reflex / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology
D006593:Hexokinase