[Experimental study of normal liver regeneration in hepatic arterial infusion with degradable starch microspheres (DSM)].
Influence of hepatic arterial infusion with degradable starch microspheres (DSM) or with anti-cancer drug or with both for normal liver regeneration in rat was determined by histological and microautoradiographical examination and liquid scintilation before or after 70% hepatectomy. DSM was seen in interlobular artery in early phase after hepatic arterial infusion, but disappeared into the central vein by degrees for 2 hours later. Adriamycin (ADM) in serum was detected for a long time after hepatic arterial infusion with DSM + ADM. In the heart muscle, a significantly lower concentration of ADM was seen in the DSM + ADM group than in the ADM only group. In the case of hepatic arterial infusion with DSM only after hepatectomy, there was no influence on normal liver regeneration. No significant difference was seen between hepatic arterial infusion and intravenous infusion with ADM only. However, in the case of hepatic arterial infusion with DSM + ADM after hepatectomy, a significant difference was seen in the inhibition of liver regeneration from any other groups.
Yoshinaka
K
K
Dept. of Surgery, Hiroshima University.
Kodama
H
H
Saeki
T
T
Kin
T
T
Jinushi
K
K
Takagami
S
S
Kirihara
Y
Y
Niimoto
M
M
Hattori
T
T
D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D006498:Hepatectomy; D006499:Hepatic Artery; D007261:Infusions, Intra-Arterial; D008099:Liver / Q000187:drug effects; D008115:Liver Regeneration / Q000187:drug effects*; D008863:Microspheres; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013213:Starch / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D014018:Tissue Distribution
D004317:Doxorubicin; D013213:Starch