[Excretion of porphyrin and porphyrin precursor during ethylene oxide inhalation].
The effect of chronic inhalation of ethylene oxide on urinary coproporphyrin and delta-aminolevulinic acid were studied. When Wistar male rats were exposed to 500 ppm ethylene oxide three times a week, daily urine volume was increased by 200-300% from the first week to the fifth week of the experimental period. After exposure, daily coproporphyrin excretion and urinary coproporphyrin per mg of creatinine increased by 250% and 141%, respectively. On the other hand, daily excretion of delta-aminolevulinic acid in urine tended to increase but did not increase significantly by creatinine-correction. We think this is the first report of ethylene oxide induced experimental porphyria.
Fujishiro
K
K
Department of Environmental Toxicology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Inoue
N
N
Mori
K
K
Ikeda
M
M
Hori
H
H
D000280:Administration, Inhalation; D000622:Aminolevulinic Acid / Q000652:urine*; D000818:Animals; D003306:Coproporphyrins / Q000652:urine*; D003404:Creatinine / Q000652:urine; D005027:Ethylene Oxide / Q000008:administration & dosage / Q000009:adverse effects*; D007982:Levulinic Acids / Q000652:urine*; D008297:Male; D011164:Porphyrias / Q000139:chemically induced / Q000652:urine; D011166:Porphyrins / Q000652:urine*; D051381:Rats; D013997:Time Factors
D003306:Coproporphyrins; D007982:Levulinic Acids; D011166:Porphyrins; D000622:Aminolevulinic Acid; D003404:Creatinine; D005027:Ethylene Oxide