Effect of cancer chemotherapy on dapsone N-acetylation in man.
The effect of cancer chemotherapy on dapsone (DDS) N-acetylation was explored in 28 patients with various malignancies. There was a significant (P = 0.01) increase in plasma monoacetydapsone/dapsone (MADDS/DDS) ratios within 24 h of the start of chemotherapy (CT), indicating an acceleration of N-acetylation.
Philip
P A
PA
Department of Clinical Pharmacology, United Medical, Guy's Hospital, London, U.K.
Harper
P G
PG
Rogers
H J
HJ
D000107:Acetylation; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001711:Biotransformation; D003622:Dapsone / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D010641:Phenotype
D000970:Antineoplastic Agents; D003622:Dapsone