Biochemical changes related to aging in the senescence-accelerated mouse.
Several biochemical parameters reflecting the degree of senescence were compared between senile-prone (P) and resistant (R) strains of male senescence-accelerated mouse (SAM) at 11 to 12 months of age. Plasma testosterone in SAM-P amounted to half the concentration in SAM-R. In the liver and brain of SAM-P, the content of malondialdehyde (MDA) and the activity of monoamine oxidase B (MAO-B) were significantly higher than those in SAM-R. Moreover, large amounts of fluorescent lipofuscin were detected in the SAM-P liver. Compared with SAM-R, both membrane and cytosolic fractions from the SAM-P liver contained small amounts of protein and showed less activity of superoxide dismutase (SOD). The present findings suggest that the male SAM-P rapidly acquires biochemical changes which are considered to be part of the normal aging process.
Nomura
Y
Y
Department of Pharmacology, Toyama Medical and Pharmacological University, Japan.
Wang
B X
BX
Qi
S B
SB
Namba
T
T
Kaneko
S
S
D000375:Aging / Q000097:blood / Q000502:physiology*; D000818:Animals; D001923:Brain Chemistry; D008062:Lipofuscin / Q000032:analysis; D008099:Liver / Q000032:analysis* / Q000201:enzymology; D008315:Malondialdehyde / Q000032:analysis; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D011506:Proteins / Q000032:analysis; D013482:Superoxide Dismutase / Q000378:metabolism; D013739:Testosterone / Q000097:blood
D008062:Lipofuscin; D011506:Proteins; D013739:Testosterone; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase