title: [Fluorescence diagnosis of porphyrin-marked urothelial tumors. Status of experimental development].
abstract: On the basis of selective storage of fluorescing hematoporphyrin derivative (HpD) in tumors, a method has been developed that enables the endoscopic detection of early-stage cancer by monitoring fluorescent images. The contrast-reducing portion of the superposed tissue autofluorescence is suppressed by the use of two-wavelength excitation and subsequent image processing in realtime. The amount of photosensitizing HpD necessary for diagnostic purposes is considerably reduced by means of sensitive detection devices. A clear distinction between benign and malignant bladder tissue seems possible according to the results of animal studies.
authors.affiliation: Urologische Klinik und Poliklinik LMU München.
authors.forename: D
authors.initials: D
authors.lastname: Jocham
authors.forename: R
authors.initials: R
authors.lastname: Baumgartner
authors.forename: N
authors.initials: N
authors.lastname: Fuchs
authors.forename: H
authors.initials: H
authors.lastname: Lenz
authors.forename: H
authors.initials: H
authors.lastname: Stepp
authors.forename: E
authors.initials: E
authors.lastname: Unsöld
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000175:diagnosis*; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced / Q000175:diagnosis*; D020684:Cystoscopes; D005453:Fluorescence; D006415:Hematoporphyrins; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D007834:Lasers; D051381:Rats; D011919:Rats, Inbred Strains; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000175:diagnosis*
chemical_list: D006415:Hematoporphyrins
vernacular_title: Die Fluoreszenzdiagnose Porphyrin-markierter urothelialer Tumoren. Stand der experimentellen Entwicklung.