title: 5-(2-bromoethyl)-2'-deoxyuridine: a selective inhibitor of herpes simplex viruses in vitro.
abstract: A new pyrimidine analog, 5-(2-bromoethyl)-2'-deoxyuridine (BEUdR), was tested in vitro for antiviral activity on Herpes simplex virus types 1 and 2. As reference compounds, ACG, BVUdR and PAA were used. Compared to ACG and BVUdR, BEUdR resulted less potent on both HSV-1 and HSV-2. However, a 50% inhibition of the multiplication of uninfected cells could be obtained only at very high BEUdR concentration (ID50 = 8500 microM). This makes BEUdR the least toxic analog known and gives it a selective index comparable to, if not better, than of ACG and BVUdR.
authors.affiliation: Institute of Microbiology, University of Cagliari, Italy.
authors.forename: P
authors.initials: P
authors.lastname: La Colla
authors.forename: A
authors.initials: A
authors.lastname: Pani
authors.forename: M E
authors.initials: ME
authors.lastname: Marongiu
authors.forename: M V
authors.initials: MV
authors.lastname: Corrias
authors.forename: O
authors.initials: O
authors.lastname: Flore
authors.forename: C
authors.initials: C
authors.lastname: Marcello
authors.forename: U
authors.initials: U
authors.lastname: Lecca
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006561:Herpes Simplex / Q000188:drug therapy*; D006801:Humans
chemical_list: D000998:Antiviral Agents; C020235:brivudine; D001973:Bromodeoxyuridine