title: Neural cell adhesion molecule (N-CAM) expression during cardiac development in the rat.
abstract: Neural cell adhesion molecule (N-CAM) expression was examined in the rat heart using immunohistochemical and immunochemical techniques. N-CAM immunoreactivity was displayed by myocardial cells from embryonic day E12 and by cardiac nerves when first identified at day E18. Myocardial immunostaining increased up until about postnatal day 1 and then declined rapidly thereafter whereas neural immunoreactivity persisted in the adult. N-CAM cardiac isoforms also exhibited developmental changes from the main embryonic moieties (105 and 145 kDa) to the principal postnatal (125 and 155 kDa) and adult isoforms (125 kDa). Cardiac N-CAM expression is therefore subject to temporal regulation and may modulate cellular interactions in the developing heart.
authors.affiliation: Department of Histochemistry, Royal Postgraduate Medical School, London, U.K.
authors.forename: J
authors.initials: J
authors.lastname: Wharton
authors.forename: L
authors.initials: L
authors.lastname: Gordon
authors.forename: F S
authors.initials: FS
authors.lastname: Walsh
authors.forename: T P
authors.initials: TP
authors.lastname: Flanigan
authors.forename: S E
authors.initials: SE
authors.lastname: Moore
authors.forename: J M
authors.initials: JM
authors.lastname: Polak
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism*; D015815:Cell Adhesion Molecules; D005314:Embryonic and Fetal Development; D005786:Gene Expression Regulation; D006321:Heart / Q000196:embryology / Q000254:growth & development*; D008970:Molecular Weight; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000954:Antigens, Surface; D015815:Cell Adhesion Molecules