[New aspects of the diagnosis of pancreatic cancer by determination of granulocyte elastase].
Elastase determination via elastase-alpha 1-antitrypsin-complex is recommended for the prognosis of septic infections. Since it is described that elastase values are increased in the serum of tumor patients it was the aim of the investigations to test elastase in the serum of different surgical tumor patients postoperatively. For comparison patients with septic complications as well as patients without any postoperative complication were also tested. It could be shown that in septic patients elastase values are markedly increased. They were measured at 390 ng/ml in mean, whereas patients without complications after operation had only values of 229 ng/ml. Elastase values in tumor patients were only slightly increased (290 ng/ml). It was, however, generally noticed that patients with pancreas head carcinoma showed regularly markedly increased elastase values (375 ng/ml). From this it was concluded that the determination of elastase values in tumor patients gives no reliable information except in patients with pancreas head carcinoma. In these patients the determination of the elastase could be helpful especially because the normal enzyme diagnosis is often misleading.
Dütschke
P
P
Seifert
J
J
Hamelmann
H
H
D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000097:blood*; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000201:enzymology / Q000601:surgery; D013530:Surgical Wound Infection / Q000175:diagnosis
D010196:Pancreatic Elastase
Neue Aspekte der Pankreaskarzinomdiagnostik durch die Bestimmung der Granulozytenelastase.