Localization of human c-mos to chromosome band 8q11 in leukemic cells with the t(8;21) (q22;q22).
Chromosome in situ hybridization studies locate c-mos to chromosome band 8q11 in leukemic cells carrying the t(8;21) (q22;q22). This amends the previous assignment of c-mos to chromosome band 8q22 and conforms with its recent assignment to 8q11 in normal cells and in a cell line with a structurally abnormal chromosome 8. C-mos lies proximally to, and distant from, the breakpoint at 8q22 in the t(8;21) and is unlikely to have a role in the onset of acute myeloid leukemia characterized by this translocation.
Morris
C M
CM
Cancer Society of New Zealand Cytogenetic and Molecular Oncology Unit, Christchurch Hospital, New Zealand.
Bowen
J
J
Fitzgerald
P H
PH
D000328:Adult; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D004273:DNA, Neoplasm / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes; D014178:Translocation, Genetic
D004273:DNA, Neoplasm