title: [Changes in the number and size of fibrillar centers in nucleolus inactivation during erythropoiesis].
abstract: The size and number of fibrillar centers (FCs) was shown to be proportional to or correlate with the ploidy of the cell, respectively. In the active nucleoli of erythroblasts, the numbers of FCs exceeds several-fold that of nucleoli organizing regions (NORs). In the course of maturation, the number of FCs becomes 3-10 times lower than that of NORs. The total size of FCs decreases three-fold during differentiation, although the size of individual FCs increases. Inactivation of ribosomal genes in the process of erythropoiesis seems to be accompanied by fusion of individual FCs and compaction of their tissue.
authors.forename: O V
authors.initials: OV
authors.lastname: Zatsepina
authors.forename: P V
authors.initials: PV
authors.lastname: Chelidze
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Chentsov
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002466:Cell Nucleolus / Q000648:ultrastructure*; D004912:Erythrocytes / Q000648:ultrastructure; D004920:Erythropoiesis; D007399:Interphase; D008099:Liver / Q000196:embryology / Q000648:ultrastructure; D051379:Mice; D008854:Microscopy, Electron; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D011003:Ploidies; D012335:RNA, Ribosomal / Q000096:biosynthesis
chemical_list: D012335:RNA, Ribosomal
vernacular_title: Izmenenie chisla i razmerov fibrilliarnykh tsentrov pri inaktivatsii iadryshek v protsesse éritropoéza.