[The role of cellular immunity in the pathogenesis of glomerulonephritis].
In this article, experimental data and clinical observations suggesting the role of cell-mediated immunity in pathogenesis of primary glomerulonephritis have been presented. Serum anti-GBM antibodies have been observed in glomerulopathies mediated by anti-glomerular basement membrane antibodies with the presence of immunoglobulins in glomeruli and in their eluates. The lymphocytes from patients with glomerular disease show cell-mediated immune reactivity against GBM antigens. Cell-mediated immune mechanisms with involvement of mononuclear cells and polymorphonuclear leukocytes may participate in the pathogenesis of various forms of glomerulonephritis and contribute to prompt deterioration of renal function.
Kacprzyk
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F
Orłowski
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D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology / Q000473:pathology; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology* / Q000473:pathology; D009000:Monocytes / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*
D001323:Autoantibodies
Rola odporności komórkowej w patogenezie kłebkowych zapaleń nerek.