[Pharmacokinetics of intravenous ketoprofen. Therapeutic value in renal colic].
The pharmacokinetics of intravenous ketoprofen were evaluated in 37 patients suffering from acute ureteral colic. Four studies were established to obtain a rapid and persistent analgesic effect: group I: 100 mg of ketoprofen as bolus; group II: short infusion of 100 mg of ketoprofen (1.5 or 2 hours); group III: loading dose of 35 mg ketoprofen plus an infusion of 25 mg/h and 33 mg/h. Serum concentrations of ketoprofen were measured by high pressure liquid chromatography. The mean (+/- SD) values of pharmacokinetic parameters measured with a 2 open compartment model were as follows: distribution half-life: 0.34 +/- 0.19 h; elimination half-life: 2.05 +/- 0.58 h; kel: 0.96 +/- 0.28 h-1; k21: 0.94 +/- 0.42 h-1; k12: 1.00 +/- 0.70 h-1; volume of central compartment: 5.58 +/- 1.67 l; volume of tissue compartment: 5.14 +/- 2.12 l; plasma clearance: 5.10 +/- 1.14 l. h-1. These results concur with previously published data obtained after oral, rectal or intramuscular administration. Ketoprofen due to its peripheric anti-inflammatory, antiprostaglandins and central actions gives the best results with the intravenous administration. Administration of a ketoprofen bolus suppressed pain within ten minutes in 71% of patients.
Hurault de Ligny
B
B
Service de Néphrologie, C.H.R.U. Clémenceau, Caen.
Debruyne
D
D
Ryckelynck
J P
JP
Levaltier
B
B
Albessard
F
F
Moulin
M
M
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003085:Colic / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006207:Half-Life; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007674:Kidney Diseases / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010666:Phenylpropionates / Q000493:pharmacokinetics*
D010666:Phenylpropionates; D007660:Ketoprofen
Pharmacocinétique du kétoprofène intraveineux. Intérêt thérapeutique dans la colique néphrétique.