[The endothelium as the central control site of the coagulation cascade].
Regulation of coagulation by endothelial cells has been the focus of intense studies during recent years. The importance of cellular receptors for coagulation factors leads to a model of the prethrombotic state and perhaps to the possibility of receptor blockade as an anticoagulant therapy. The prethrombotic state is initiated by stimuli such as interleukin 1, Tumor Necrosis Factor, endotoxin, or norepinephrine. These agents shift the steady state of coagulant reactions on the surface of normal anticoagulant active endothelial cells to a prethrombotic surface, capable of initiating coagulation and promoting clot formation. These stimulated endothelial cells have an increased expression of procoagulant and a decreased expression of anticoagulant binding sites for clotting factors.
Nawroth
P P
PP
Medizinische Klinik, Abt. I, Universität Heidelberg, FRG.
Stern
D M
DM
D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000502:physiology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006133:Growth Substances / Q000502:physiology*; D006474:Hemorrhagic Disorders / Q000097:blood*; D006801:Humans; D013927:Thrombosis / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D001779:Blood Coagulation Factors; D006133:Growth Substances; D014409:Tumor Necrosis Factor-alpha
Das Endothel als zentrale Schaltstelle der Gerinnungskaskade.