Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin.
Intradermal injection of 100 micrograms of capsaicin in cats excited dorsal horn spinal neurons classified as either 'high threshold' or 'wide dynamic range'. Capsaicin enhanced their responses to innocuous mechanical stimulation. A role for these neurons in mechanical hyperalgesia is suggested.
Simone
D A
DA
Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510.
Baumann
T K
TK
Collins
J G
JG
LaMotte
R H
RH
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D002415:Cats; D005260:Female; D008297:Male; D008465:Mechanoreceptors / Q000187:drug effects / Q000502:physiology*; D010812:Physical Stimulation; D012684:Sensory Thresholds / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*
D002211:Capsaicin