title: Objective measures of swallowing in patients with primary Sjogren's syndrome.
abstract: Primary Sjogren's syndrome (SS) is an autoimmune disorder primarily affecting salivary and lacrimal glands. Durational measures of the oral phase of swallowing were obtained on 34 patients with primary SS and 34 age-matched controls from analyses of ultrasound scans. Two conditions were examined: a basal (BA) swallow (only endogeneous secretions present in the subjects' mouths) and a 10 ml water bolus (WB) swallow. The patients with SS produced swallowing durations significantly longer (p less than 0.05) than those of the controls for each of the two conditions. Moreover, unlike normals, over 40% of the patients with SS produced WB swallows that were longer than their BA swallows. For further analyses, patients with SS were classified into two groups based on the difference in duration between their BA and WB swallows. These two groups differed from each other on clinical evaluations of oral motor function and presenting complaints. No significant differences were found between these two groups for salivary function or immunologic profile. These findings support the hypothesis that dysphagia can result from conditions leading to salivary gland dysfunction and document the need for the assessment of swallowing function in patients with Sjogren's syndrome.
authors.forename: A J
authors.initials: AJ
authors.lastname: Caruso
authors.forename: B C
authors.initials: BC
authors.lastname: Sonies
authors.forename: J C
authors.initials: JC
authors.lastname: Atkinson
authors.forename: P C
authors.initials: PC
authors.lastname: Fox
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003679:Deglutition; D006801:Humans; D008875:Middle Aged; D012463:Saliva / Q000378:metabolism; D012859:Sjogren's Syndrome / Q000503:physiopathology*; D014463:Ultrasonography