The genetics of Crohn disease: complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives.
We have analysed the pedigrees of 265 probands with Crohn disease, collected from a specialty clinic at the University of Düsseldorf. Complex segregation analysis suggests the presence of a recessive gene with incomplete penetrance for susceptibility to the disease with no residual causes of family resemblance. However, a proportion of the isolated cases are probably due to phenocopies, this proportion being greatest among cases with an advanced age of onset.
Küster
W
W
Department of Dermatology, University of Düsseldorf, Federal Republic of Germany.
Pascoe
L
L
Purrmann
J
J
Funk
S
S
Majewski
F
F
D002874:Chromosome Mapping; D003424:Crohn Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005808:Genes, Recessive; D005860:Germany, West; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype