[Kinetics of the oxidative deamination reaction in the preconvulsive period of oxygen-induced epilepsy].
Kinetic parameters of monoamine oxidative deamination in compensatory and preconvulsive periods of oxygen epilepsia were studied. It was shown that in rat brain MAO's affinity for serotonin reduced from the 5th minute of exposure to hyperbaric oxygen and went on reducing on the 15th minute. In rat heart the affinity of MAO for serotonin firstly decreased and then returned to normal meaning. Dopamine deamination in rat brain in compensatory period of epilepsia was activated and then was inhibited. In rat heart from the 5th minute of exposure to oxygen dopamine and 2-phenylethylamine deamination was blocked. Tyramine deamination in preconvulsive period of epilepsia changed in a complex manner. It is concluded that the kinetic parameters of monoamine deamination change in the initial phases of exposure to hyperbaric oxygen, and the most distinct modifications take place in rat heart, but not in rat brain.
Gol'dina
O A
OA
Gankina
E M
EM
Mansil'ia
V A
VA
Koloskov
Iu B
IuB
Demurov
E A
EA
D000818:Animals; D001273:Atmosphere Exposure Chambers; D001921:Brain / Q000201:enzymology; D003641:Deamination; D004298:Dopamine / Q000378:metabolism; D004827:Epilepsy / Q000139:chemically induced / Q000201:enzymology*; D007700:Kinetics; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology; D010084:Oxidation-Reduction; D010100:Oxygen / Q000633:toxicity*; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000201:enzymology*; D012701:Serotonin / Q000378:metabolism; D013379:Substrate Specificity; D013997:Time Factors
D012701:Serotonin; D008995:Monoamine Oxidase; D010100:Oxygen; D004298:Dopamine
Kinetika reaktsii okislitel'nogo dezaminirovaniia v dosudorozhnom periode kislorodnoĭ épilepsii.