Effect of ether lipids on mouse granulocyte-macrophage progenitor cells.
In this study we determined the potential bone marrow toxicity of the ether lipid derivatives 1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine (OcMe-G-3-PC), 1-0-hexadecyl-propanediol-2-phosphocholine (He-Pr-2-PC), and hexadecylphosphocholine (He-PC). OcMe-G-3-PC inhibited the proliferation of mouse granulocyte-macrophage progenitor cells (GM-CFCs) at a dose of 1 micrograms/ml, whereas He-Pr-2-PC and He-PC started to inhibit the growth of hemopoietic precursors at 5 micrograms/ml. In contrast to this finding, NMRI mice given 10 mg/kg i.v. daily for 4 weeks and 20 or 30 mg/kg for 5 days showed no bone marrow toxicity. We conclude that the dose-dependent toxic effects observed in vitro are within the physiological tolerance in vivo.
Vehmeyer
K
K
Medizinische Universitätsklinik, Abteilung Hämatologie/Onkologie, Göttingen, Federal Republic of Germany.
Kim
D J
DJ
Nagel
G A
GA
Eibl
H
H
Unger
C
C
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D007958:Leukocyte Count; D008244:Lysophosphatidylcholines / Q000494:pharmacology; D051379:Mice; D010742:Phospholipid Ethers / Q000494:pharmacology* / Q000633:toxicity; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000494:pharmacology
D000970:Antineoplastic Agents; D008244:Lysophosphatidylcholines; D010742:Phospholipid Ethers; D010767:Phosphorylcholine; C006065:We 201; C026659:edelfosine; C039128:miltefosine