[The effect of ibuprofen on the hemodynamics of the lesser circulation in patients with pulmonary hypertension].
The effect of ibuprofen on pulmonary circulation hemodynamics, pulmonary ventilation and blood gaseous metabolism was studied under conditions of cardiac venous catheterization in 8 patients with pulmonary hypertension caused by chronic inflammatory diseases of the lungs. After oral use of ibuprofen in a dose of 0.4 g, there was (in 7 out of the 8 patients) an increase in the right ventricle systolic pressure at an average by 5.9 +/- 2.39 mm Hg (p less than 0.05). The time course of the echocardiographic indices in the majority of the patients was evident of an increase in the right ventricle postload. No definite tendencies in changing of pulmonary ventilation and blood gaseous metabolism were observed. Inhibition of synthesis of prostacyclin and type E prostaglandin having a vasodilating action is the most likely mechanism of the ibuprofen vasoconstrictive effect.
Gavrisiuk
V K
VK
Morozova
N A
NA
Iachnik
A I
AI
Morskaia
N D
ND
D000328:Adult; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D007052:Ibuprofen / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation / Q000187:drug effects*
D007052:Ibuprofen
Vliianie ibuprofena na sostoianie gemodinamiki malogo kruga u bol'nykh s legochnoĭ gipertenzieĭ.