[Tetraphenylporphyrin-Sn4+ induction of cytochrome P-450].
TPP-Sn4+ was administered intraperitoneally (25 mg/kg body weight). The study was performed for 1-30 days. A day after administration the increase in the hemoprotein level 1.4 times was observed, as well as an increase in the level of p-hydroxylation of aniline. On 7-14 days the greatest increase in cytochrome P-450 content was observed. To clarity the mechanism of TPP-Sn4+ effect on cytochrome P-450, we studied its effect on the activity of heme oxygenase and LP rate. This compound is an inhibitor of heme oxygenase activity and reduces the rate of LP in the microsomes which regulates porphyrin metabolism in the organism.
Golovenko
N Ia
NIa
Galkin
B N
BN
Filippova
T O
TO
ZHilina
Z I
ZI
Tiunov
L A
LA
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D006419:Heme Oxygenase (Decyclizing) / Q000032:analysis / Q000037:antagonists & inhibitors; D006900:Hydroxylation; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008665:Metalloporphyrins / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010105:Oxygenases / Q000032:analysis; D051381:Rats; D013997:Time Factors; D014001:Tin / Q000494:pharmacology*
D008665:Metalloporphyrins; C059581:tin tetraphenylporphyrin; D014001:Tin; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D006419:Heme Oxygenase (Decyclizing)
Induktsiia tetrafenilporfirinom-Sn4+ tsitokhroma P-450.