title: Effect of prenatal and postnatal fluoride on the human deciduous dentition. A literature review.
abstract: Fluoride passes from the mother to fetal teeth. Much of the fluoride is taken up in secretory enamel, probably by the forming mineral apatite crystals. Some is retained with residual proteins. The low concentration of fluoride in the inner enamel is incorporated mainly during the secretory stage, while the enhanced concentration in the surface enamel is produced during the much longer maturation stage. Mature, hard enamel is generally absent during fetal life. The clinical question is whether prenatal fluoride imparts an additional benefit to the universally accepted effect of postnatal fluoride. In general, surface enamel fluoride levels of deciduous teeth increase with increasing pre- and postnatal fluoride administration. A consistent level of caries protection has been reported with pre- and postnatal administration of fluoride unrelated to the acquisition of fluoride in the surface enamel. Many children develop enamel opacities in their deciduous dentition related by various factors to enamel mineralization disturbances in drinking water areas even low in fluoride. Accumulation of fluoride due to an increased fluoride intake is a feature of fluorosed enamel in the deciduous as well as permanent dentition. The resulting mature fluorosed enamel retains a relatively high proportion of immature matrix proteins onto the crystal surface. The degree of fluorosis of the deciduous dentition is less compared with that of the permanent dentition, due probably to a partial protection afforded by the maternal loss of fluoride, formerly known as the "placental barrier".
authors.forename: I
authors.initials: I
authors.lastname: Gedalia
authors.forename: L
authors.initials: L
authors.lastname: Shapira
mesh_terms: D003743:Dental Enamel / Q000187:drug effects / Q000254:growth & development*; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000494:pharmacology*; D009050:Fluorosis, Dental / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D014094:Tooth, Deciduous / Q000187:drug effects / Q000254:growth & development*
chemical_list: D005459:Fluorides