title: Clinical comparison of 99Tcm-HMPAO labelled leucocytes and 99Tcm-nanocolloid in the detection of inflammation.
abstract: Forty-five patients with various inflammatory diseases were imaged with 99Tcm-HMPAO labelled leucocytes and 99Tcm-nanocolloid within 7 days. The overall sensitivity of 99Tcm-leucocytes was 97% and that of 99Tcm-nanocolloid 59% and both agents had a 100% specificity. The 99Tcm-leucocyte method showed reliable results in various inflammatory and infectious conditions, and seems suitable as a primary imaging method. On the contrary, 99Tcm-nanocolloid cannot be recommended for use in inflammatory bowel diseases, soft tissue abscesses or prosthetic vascular graft infections. However, 99Tcm-nanocolloid gave reliable information in inflammatory and infectious bone and joint diseases in which it had a 90% sensitivity and 100% specificity. In those lesions the 99Tcm-nanocolloid method may be useful, because it is simple, fast and cheap. Yet, further evaluation is needed.
authors.affiliation: Department of Nuclear Medicine, Päijät-Häme Central Hospital, Lahti, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Vorne
authors.forename: T
authors.initials: T
authors.lastname: Lantto
authors.forename: S
authors.initials: S
authors.lastname: Paakkinen
authors.forename: S
authors.initials: S
authors.lastname: Salo
authors.forename: I
authors.initials: I
authors.lastname: Soini
mesh_terms: D000038:Abscess / Q000000981:diagnostic imaging; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001168:Arthritis / Q000000981:diagnostic imaging; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000000981:diagnostic imaging*; D015212:Inflammatory Bowel Diseases / Q000000981:diagnostic imaging; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010000:Osteitis / Q000000981:diagnostic imaging; D010091:Oximes; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013668:Technetium Tc 99m Aggregated Albumin; D019690:Technetium Tc 99m Exametazime
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D013668:Technetium Tc 99m Aggregated Albumin; D019690:Technetium Tc 99m Exametazime