[Acetylcholinesterase negativity in the lamina propria in the first 8 weeks of life does not exclude Hirschsprung disease].
In a total of 34 children with Hirschsprung's disease, 7 cases showed at first biopsy a normal lamina propria mucosae without aberrant acetylcholine esterase (ACHE)-positive fibres. In further biopsies all 7 cases showed the typical pattern of abundant ACHE-positive nerve fibres in the lamina propria, the last one at the age of 8 weeks. This data suggests that in children with Hirschsprung's disease who have not yet attained their 8th week of life, approximately one-third are without the typical aberrant nerves in the lamina propria. Therefore, we emphasize that a biopsy taken before the 8th week of life showing a negative morphological result should be repeated if the clinical suspicion remains. The late sprouting of the pathological nerves should be considered especially if there are abundant ACHE-positive fibres in the lamina muscularis mucosae.
Novak
N
N
Institut für Hirnforschung der Universität Tübingen.
Peiffer
J
J
D000110:Acetylcholinesterase / Q000032:analysis*; D001706:Biopsy; D006627:Hirschsprung Disease / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007413:Intestinal Mucosa / Q000473:pathology*; D012007:Rectum / Q000473:pathology
D000110:Acetylcholinesterase
Acetylcholinesterase-Negativität der Lamina propria spricht in den ersten acht Lebenswochen nicht gegen Morbus Hirschsprung.