[Epidemiology of Horton's disease. Is there an environmental factor, infective in particular?].
Epidemiological studies of temporal arteritis have essentially only been reported in the English literature. The authors of this study were concerned with this aspect of temporal arteritis in the Loire-Atlantique region of France over a period of 10 years (1970-1979). The high prevalence in white races has been confirmed. The annual incidence in France is comparable to that seen in Northern Europe and the USA. The incidence of the disease is especially high between 70 and 80 years. The apparent female predominance is related to the greater life expectancy in women. The study of several conjugal cases does not suggest the intervention of an infectious agent. The same is true for isolated cases where the responsibility of a bacterial or viral agent has not been demonstrated. Other environmental factors (sun exposure, life-style, socio-professional classification) do not affect the incidence of the disease. The genetic background would seem to be of particular importance. This study found a significantly higher prevalence of HLA DR4 antigen, confirming the results of American and British studies. However, in contrast to previous studies, this series did not confirm an increase in HLA B8 antigen.
Barrier
J H
JH
Service de Médecine Interne II, Hôtel-Dieu, C.H.U., Nantes.
Ponge
T
T
Billaudel
S
S
de Haldat du Lys
F
F
Mussini
J M
JM
Grolleau
J Y
JY
D004777:Environment; D005260:Female; D013700:Giant Cell Arteritis / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000382:microbiology; D006801:Humans; D008297:Male
Epidémiologie de la maladie de Horton. Existe-t-il un facteur d'environnement, en particulier infectieux?