Preparation of microencapsulated liposomes, II. Systems containing nylon-gelatin and nylon-gelatin-acacia walling material.
Liposome suspension was encapsulated and isolated in nylon-gelatin and nylon-gelatin-acacia walled microcapsules. The resulting liposomal microcapsules could be stored in the dry state as a free-flowing powder. Liposomes remained intact after the microencapsulation, and encapsulation efficiency was greater than 90 per cent. The release of drug from microcapsules was retarded in the presence of drug-loaded liposomes.
Nixon
J R
JR
Chelsea Department of Pharmacy, King's College London, U.K.
Yeung
V W
VW
D000045:Acacia; D002214:Capsules; D004337:Drug Carriers; D005780:Gelatin; D008081:Liposomes / Q000032:analysis; D008855:Microscopy, Electron, Scanning; D009757:Nylons; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010599:Pharmacokinetics; D014197:Trees
D002214:Capsules; D004337:Drug Carriers; D008081:Liposomes; D009757:Nylons; D004364:Pharmaceutical Preparations; D005780:Gelatin