title: Megakaryocyte colony-stimulating factor and thrombopoiesis.
abstract: Although megakaryocyte differentiation and proliferation is understood to be regulated by "humoral" factors, the molecular identities of such factors have, until recently, been obscure. The "two factor" model of megakaryocytopoiesis/thrombopoiesis is critically reviewed. In this model, "Megakaryocyte Colony-Stimulating Factor" (Meg-CSF) determines the early differentiational events of megakaryocytopoiesis, and "Thrombopoietin" (Tpo) is held responsible for the maturation of the megakaryocyte and the biochemical/cytological events in platelet formation and release. To date, neither of these growth factors have been molecularly cloned. When this occurs, the clarification of the roles Meg-CSF, Tpo and other secondary modulators (such as IL-3 and GM-CSF) play in platelet formation in health and disease will be made manifest.
authors.affiliation: Hipple Cancer Research Center, Dayton, Ohio.
authors.forename: M J
authors.initials: MJ
authors.lastname: Murphy
mesh_terms: D000818:Animals; D001792:Blood Platelets; D002454:Cell Differentiation / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000502:physiology*; D058851:GPI-Linked Proteins; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007377:Interleukin-3 / Q000502:physiology; D008533:Megakaryocytes / Q000187:drug effects*; D008562:Membrane Glycoproteins; D000090204:Mesothelin; D011506:Proteins / Q000502:physiology*; D013926:Thrombopoietin / Q000502:physiology
chemical_list: D003115:Colony-Stimulating Factors; D058851:GPI-Linked Proteins; D007377:Interleukin-3; D008562:Membrane Glycoproteins; D011506:Proteins; D013926:Thrombopoietin; D000090204:Mesothelin