Developmental toxicity testing with FETAX: evaluation of five compounds.
The teratogenic potential of five compounds was evaluated with FETAX (Frog Embryo Teratogenesis Assay: Xenopus). Early embryos of Xenopus laevis were exposed for 96 h to 6-aminonicotinamide (6-AN), isoniazid (INH), urethane, nitrilotriacetate (NTA) or sodium cyclamate, in two separate static-renewal tests of each compound. Based on Teratogenic Index values, growth endpoints and the types and severity of the induced malformations, 6-AN, INH and urethane scored as having strong teratogenic potential. NTA and sodium cyclamate had little or no teratogenic potential. The results support continued evaluation of FETAX as a screening assay for chemical teratogens.
Dawson
D A
DA
Department of Zoology, Oklahoma State University, Stillwater 74078.
Fort
D J
DJ
Newell
D L
DL
Bantle
J A
JA
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D007928:Lethal Dose 50; D013723:Teratogens / Q000633:toxicity*; D013997:Time Factors; D014982:Xenopus laevis
D013723:Teratogens