Effect of cefazolin on the corneal endothelium. An experimental study.
Cefazolin sodium was injected into the anterior chamber of the rabbit eye in order to evaluate its effect upon the corneal endothelium. Endothelial toxicity was evaluated by contact specular microscopy and transmission electron microscopy 48 h after injection. The results suggest that doses of 1 and 2 mg of cefazolin are nontoxic to the corneal endothelium. Endothelial toxicity occurred when 5 and 10 mg of cefazolin were injected.
Petroutsos
G
G
Laboratoire d'Ophtalmologie, Unité INSERM 86, Paris, France.
Savoldelli
M
M
Pouliquen
Y
Y
D000818:Animals; D002437:Cefazolin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004728:Endothelium, Corneal / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D007267:Injections; D008854:Microscopy, Electron; D011817:Rabbits
D002437:Cefazolin