Inhibitor of normal granulopoiesis produced by cells of MDS patients.
Low-density blood cells from patients with refractory anemia with excess of blasts (RAEB) and RAEB in transformation (RAEB-T) release a high molecular weight inhibitory substance that reduces the entry of normal progenitor cells of granulocytes and macrophages (CFU-GM) into the S-phase. Out of 20 patients with refractory anemia (RA and RAS) only 3 were positive. One patient with CMML was negative. Serial examination of 3 patients (two RA and one CMML) revealed that the production of the inhibitory activity preceded the development of the disease into RAEB, RAEB-T, or AML. With one exception, the inhibitory activity in positive cases was neutralized by antiserum against human placental ferritin.
Cukrová
V
V
Institute of Hematology and Blood Transfusion, Prague, Czechoslovakia.
Neuwirtová
R
R
Cermák
J
J
Neuwirt
J
J
D000753:Anemia, Refractory / Q000209:etiology; D001856:Bone Marrow Examination; D005293:Ferritins / Q000502:physiology; D006098:Granulocytes / Q000502:physiology*; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D008222:Lymphokines / Q000096:biosynthesis*; D008264:Macrophages / Q000502:physiology; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000378:metabolism*
D008222:Lymphokines; C022173:stem cell inhibitory factor; D005293:Ferritins