[Secondary L-carnitine deficiency in chronic hemodialysis patients].
L-carnitine is an essential substance for the decomposition of long-chain fatty acids and thus for the obtaining of energy in the mitochondria. The L-carnitine fractions in the serum were analysed in 10 patients undergoing haemodialysis before and after the dialysis treatment. 4 patients received a substitution of L-carnitine by oral application of 3.0 and 1.0 g, respectively, after every dialysis or as addition to the dialysate (ca. 62 mumol/l) for in each case 4 weeks. In patients undergoing dialysis the serum carnitine fractions were in many cases already clearly diminished before the dialysis. During the treatment the total L-carnitine levels decreased by ca. 50%, the free L-carnitine values by ca. 70%. Particularly distinct carnitine depletions were found in patients with catabolic metabolic condition, incompatibility of dialysis and post-dialysis syndrome. All forms of application and dosages chosen led to a good correction of the serum carnitine concentrations. 2 patients with oral L-carnitine substitution of 3.0 g and resulting from this serum carnitine levels highly significantly lying above the normal region mentioned ameliorations of the subjective lipid parameters cholesterol, HDL-cholesterol and triglycerides could not be changed in the short period of observation by substitution of L-carnitine.
Achenbach
H
H
Klinik für Innere Medizin, Karl-Marx-Universität Leipzig.
Würzberger
G
G
Seim
H
H
Löster
H
H
Strauss
B
B
D000328:Adult; D002331:Carnitine / Q000008:administration & dosage / Q000172:deficiency*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D002331:Carnitine
Untersuchungen zum sekundren L-Carnitinmangel bei chronischen Hämodialysepatienten.