[Effect of alpha-hydroxydimethyl-gamma-aminopropylidene bisphosphonate on the bone tissue of rats during hypokinesia].
The preventive effect of alpha-hydroxydimethyl-gamma-aminopropylidene bis-phosphonate was investigated histomorphometrically. The agent was injected subcutaneously to rats before hypokinesia at a dose of 5 mg/kg or during 35-day hypokinesia at a dose of 0.005 or 0.01 mg/kg daily. Regardless of the treatment protocol, the agent prevented osteoporosis and did not affect the epiphyseal growth plate. The agent modified significantly the bone cell count: osteoblasts decreased and osteoclasts increased. It is concluded that when compared to xydiphone (hydroxyethylidene bis-phosphoric acid), the agent proves several hundred times more effective. It is assumed that the agent modifies the relation between bone formation and bone resorption. Its osteotropic effect manifests as inhibition of bone resorption.
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D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology; D002452:Cell Count / Q000187:drug effects; D004164:Diphosphonates / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical; D007103:Immobilization; D007279:Injections, Subcutaneous; D010006:Osteoblasts / Q000187:drug effects* / Q000473:pathology; D010010:Osteoclasts / Q000187:drug effects* / Q000473:pathology; D010024:Osteoporosis / Q000517:prevention & control*; D010919:Placebos; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004164:Diphosphonates; D010919:Placebos; C055774:olpadronic acid
Vliianie alpha-oksidimetil-gamma-aminopropilidena bisfosfonata na kostnuiu tkan' krys pri gipokinezii.