title: The CT and MR evaluation of migrational disorders of the brain. Part I. Lissencephaly and pachygyria.
abstract: The migrational disorders are a rare group of congenital malformations of the brain. They consist of the following entities--lissencephaly (agyria-pachygyria), pachygyria, schizencephaly, heterotopia and polymicrogyria. We studied 40 children with migrational disorders radiologically with CT and MR. This article (part I) deals with our patients their characteristic CT and MR findings along with their clinical presentation and course. These patients presented with one or a combination of the following symptoms, hypotonia, seizures, failure to thrive, microcephaly and occasionally hydrocephalus. These two groups of migrational disorders have abnormalities affecting the gyral-sulcal pattern of the cortex and gray-white matter distribution of the brain. MR provided better delineation of these disorders than CT. Because some forms of the migrational disorders can be inherited, it is extremely important for the radiologist to understand the characteristic findings for correct diagnosis which is essential for parental counseling.
authors.affiliation: Department of Radiology, Children's Memorial Hospital, Northweastern University Medical School, Chicago, Illinois.
authors.forename: S E
authors.initials: SE
authors.lastname: Byrd
authors.forename: R E
authors.initials: RE
authors.lastname: Osborn
authors.forename: T P
authors.initials: TP
authors.lastname: Bohan
authors.forename: T P
authors.initials: TP
authors.lastname: Naidich
mesh_terms: D001921:Brain / Q000002:abnormalities*; D002540:Cerebral Cortex / Q000002:abnormalities*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D013577:Syndrome; D014057:Tomography, X-Ray Computed