Effects of enterally- and parenterally-administered bombesin on intestinal luminal tryptic activity and protein in the suckling rat.
Because of the presence of bombesin-like immunoreactivity in milk, we investigated if enteral administration of bombesin affects the intestinal luminal content of trypsin and protein in 12-14-day-old rats. Bombesin (40 micrograms/kg), given either orogastrically or subcutaneously, produced a significant elevation in the intestinal content of trypsin activity. Thus, enterally-administered bombesin can produce acute biologic effects in suckling rats.
Pollack
P F
PF
Department of Pediatrics, University of Arizona Health Sciences Center, Tucson 85724.
Adamson
C
C
Koldovsky
O
O
D000284:Administration, Oral; D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism*; D001839:Bombesin / Q000008:administration & dosage / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects; D007700:Kinetics; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014357:Trypsin / Q000378:metabolism*
D011506:Proteins; D014357:Trypsin; D001839:Bombesin