Mapping the short arm of human chromosome 16.
Physical mapping of 13 different breakpoints on the short arm of chromosome 16 using previously mapped probes and the subsequent mapping of additional probes enabled the division of this portion of the chromosome into six different intervals. D16S94 was mapped between HBA and D16S80 and is closer to PKD1 than either HBA or D16S80. A tight linkage group which includes FRA16A, D16S8, and D16S79 was identified. Seven breakpoints, including FRA16A, could not be separated by probe localizations. This study provides the basis for the development of detailed maps of the short arm of chromosome 16.
Callen
D F
DF
Cytogenetics Unit, Adelaide Children's Hospital, South Australia.
Hyland
V J
VJ
Baker
E G
EG
Fratini
A
A
Gedeon
A K
AK
Mulley
J C
JC
Fernandez
K E
KE
Breuning
M H
MH
Sutherland
G R
GR
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure; D015342:DNA Probes; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009693:Nucleic Acid Hybridization
D015342:DNA Probes