Structure of a mutagen from roasted seeds of Moringa oleifera.
A mutagenic compound was isolated from roasted seeds of Moringa oleifera Lam. Its structure has been elucidated by spectral analysis as 4(alpha-L-rhamnosyloxy)phenylacetonitrile. The results of the Micronucleus Test, an in vivo method, showed that the number of micronucleated polychromatic erythrocytes (PCE)/1000 PCE for this compound is higher than that of the solvent control, dimethylsulfoxide, and approximates that of the positive control, tetracycline. This indicates that 4(alpha-L-rhamnosyloxy)phenylacetonitrile is a genotoxic compound.
Villasenor
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Institute of Chemistry, University of the Philipines, Diliman, Quezon City.
Finch
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Lim-Sylianco
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Dayrit
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D000097:Acetonitriles / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015162:Micronucleus Tests; D009132:Muscles / Q000187:drug effects; D009153:Mutagens / Q000302:isolation & purification*; D012639:Seeds / Q000032:analysis*
D000097:Acetonitriles; D006027:Glycosides; D009153:Mutagens; C059985:4-(rhamnosyloxy)phenylacetonitrile