New antitumor antibiotic, FR-900462. II. Production, isolation, characterization and biological activity.
FR-900462 is a new antitumor antibiotic produced by Streptomyces tokashikiensis No. 7124. It was highly active against leukemia P388 and melanoma B16. Furthermore, it has weak antimicrobial activity against some Gram-positive bacteria.
Iwami
M
M
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Nakayama
O
O
Okuhara
M
M
Terano
H
H
Kohsaka
M
M
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification / Q000627:therapeutic use; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005260:Female; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D009368:Neoplasm Transplantation; D009930:Organic Chemicals; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D009930:Organic Chemicals; C059808:FR 900462