Drug uptake and release by a hydrogel intraocular lens and the human crystalline lens.
Implantation of a hydrogel (IOGEL) intraocular lens in humans has been reported. The polyhydroxyethyl methacrylate (poly HEMA) matrix of this hydrogel is permeable to water soluble drugs and may adsorb agents used intracamerally during cataract extraction or topically during the postoperative period. This study compared the in vitro uptake and release of chloramphenicol, dexamethasone, epinephrine, pilocarpine, and bovine serum albumin by polymethylmethacrylate and hydrogel intraocular lenses with that of the intact crystalline lens of humans and rabbits. An in vivo study compared the uptake and release of chloramphenicol and dexamethasone by hydrogel lenses implanted in the anterior chamber of rabbit eyes with that of the rabbit's crystalline lens. The in vitro uptake and washout of epinephrine and pilocarpine by the hydrogel lens was comparable to the human lens. Uptake of chloramphenicol and dexamethasone by the hydrogel lens exceeded that of the human lens and, following a two-hour washout period, the dexamethasone content of the hydrogel lens remained significantly greater than the human lens. The uptake and washout of bovine serum albumin by the hydrogel lens was half that of the human lens. In vivo, the hydrogel lens efficiently eluted both chloramphenicol and dexamethasone. These studies show that a hydrogel lens will not act as a significant depot for drugs in the eye.
Heyrman
T P
TP
Department of Physiology, Medical College of Wisconsin, Milwaukee.
McDermott
M L
ML
Ubels
J L
JL
Edelhauser
H F
HF
D000818:Animals; D002701:Chloramphenicol / Q000493:pharmacokinetics; D003907:Dexamethasone / Q000493:pharmacokinetics; D004347:Drug Interactions; D004837:Epinephrine / Q000493:pharmacokinetics; D005123:Eye / Q000378:metabolism; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism*; D007910:Lenses, Intraocular; D008768:Methylmethacrylates / Q000494:pharmacology; D010862:Pilocarpine / Q000493:pharmacokinetics; D011102:Polyhydroxyethyl Methacrylate / Q000494:pharmacology*; D011109:Polymethacrylic Acids / Q000494:pharmacology*; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000493:pharmacokinetics
D008768:Methylmethacrylates; D011109:Polymethacrylic Acids; D010862:Pilocarpine; D011102:Polyhydroxyethyl Methacrylate; D012710:Serum Albumin, Bovine; D002701:Chloramphenicol; D003907:Dexamethasone; D004837:Epinephrine