title: Comparison of single breath carbon monoxide diffusing capacity and pressure-volume curves in detecting emphysema.
abstract: To evaluate the sensitivity of diffusing capacity (DLCO) and pressure-volume (P-V) curves in the detection of emphysema, these tests were compared with pathologic assessment of emphysema in patients undergoing lung resection for a localized tumor, and with the overall extent of emphysema as assessed by computed tomography (CT). The resected lung specimens were fixed in the inflated state and cut at 1-cm intervals in the horizontal plane. The pathologic extent of emphysema was quantitated by comparison with a standard reference panel of emphysema grading. The overall extent of emphysema on CT was assessed by a visual scoring system in a total of 55 patients, 19 undergoing lung resection and 36 not undergoing lung resection. Analysis of 37 patients by pathology scores revealed 18 with no or trivial emphysema (emphysema grades less than or equal to 5; mean grade, 2.2 +/- SD 2.6) and 19 with emphysema (grades greater than or equal to 10; mean grade, 33.2 +/- SD 24.2). Diffusing capacity, the ratio of DLCO to alveolar volume (DLCO/VA), maximal lung elastic recoil (PLmax), and lung elastic recoil at 90% of total lung capacity (PL90) were significantly different between the two groups, whereas K (the exponential constant describing the shape of the P-V curve) was not. The pathology grade of emphysema showed a significant correlation with (DLCO) (r = -0.53) and DLCO/VA (r = -0.55), which was greater than the correlation with PLmax (r = -0.42) and PL90 (r = -0.43).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pathology, University of British Columbia, Vancouver General Hospital, Canada.
authors.forename: N J
authors.initials: NJ
authors.lastname: Morrison
authors.forename: R T
authors.initials: RT
authors.lastname: Abboud
authors.forename: F
authors.initials: F
authors.lastname: Ramadan
authors.forename: R R
authors.initials: RR
authors.lastname: Miller
authors.forename: N N
authors.initials: NN
authors.lastname: Gibson
authors.forename: K G
authors.initials: KG
authors.lastname: Evans
authors.forename: B
authors.initials: B
authors.lastname: Nelems
authors.forename: N L
authors.initials: NL
authors.lastname: Müller
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002248:Carbon Monoxide; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000503:physiopathology; D008175:Lung Neoplasms / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D011653:Pulmonary Diffusing Capacity / Q000187:drug effects*; D011656:Pulmonary Emphysema / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D014057:Tomography, X-Ray Computed
chemical_list: D002248:Carbon Monoxide