title: Clear-cell syringoma. Immunohistochemistry and electron microscopy study.
abstract: Clear-cell syringoma is a histologic variant of syringoma that is otherwise clinically indistinguishable from ordinary syringoma. This variant is formed by cells that have pale or clear cytoplasm as a result of glycogen accumulation. There is a high association of clear-cell syringoma and diabetes mellitus. A case of clear-cell syringoma associated with diabetes mellitus is described. Electron microscopic examination revealed that periluminal cells showed intra- and extracytoplasmic multivesicular bodies that may be characteristic of the clear-cell variant. Immunohistochemistry for carcinoembryonic antigen (CEA) showed ordinary syringomas as in the presence of CEA within and surrounding duct-like spaces.
authors.affiliation: Department of Dermatology, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Ambrojo
authors.forename: L
authors.initials: L
authors.lastname: Requena Caballero
authors.forename: A
authors.initials: A
authors.lastname: Aguilar Martínez
authors.forename: E
authors.initials: E
authors.lastname: Sánchez Yus
authors.forename: V
authors.initials: V
authors.lastname: Furió
mesh_terms: D000236:Adenoma / Q000032:analysis / Q000648:ultrastructure*; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003593:Cytoplasm / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004848:Epithelium / Q000648:ultrastructure; D005142:Eyelid Neoplasms / Q000032:analysis / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D013544:Sweat Gland Neoplasms / Q000032:analysis / Q000648:ultrastructure*
chemical_list: D002272:Carcinoembryonic Antigen