[Species-specific reactions of succinate dehydrogenase of lymphocytes in animals to acute hypoxic hypoxia and its relation to the radiation resistance of the body].
Experiments on rats and dogs showed that acute hypoxic hypoxia caused an increase of succinate dehydrogenase (SDH) in blood lymphocytes. The rate of SDH increase (VSDH) depended on the oxygen concentration in the breathing hypoxic mixture (BHM) and the animal species. In dogs it proved to be lower than in rats. Experiments on mice, rats and dogs were carried out to study the correlation between the level of the dose decrease factor (DDF) of the BHM and the animal species. The radiation resistance of the animal body in a hypoxic environment was evaluated with respect to the severity of the hypoxic state. A formula has been developed that can help determine ionizing radiation resistance of the animal in a hypoxic state. The formula based on the lymphocyte VSDH is as follows: DDF of BHM = 0.97 + 0.215 VSDH. By calculating the radioprotective effect of the BHM as a function of oxygen consumption, the applicability of the formula to such animal species as rats and dogs has been verified.
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Gaĭdamakin
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D000818:Animals; D003037:Cobalt Radioisotopes / Q000008:administration & dosage*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D000860:Hypoxia / Q000097:blood*; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D051379:Mice; D010100:Oxygen / Q000008:administration & dosage*; D011829:Radiation Dosage; D011836:Radiation Tolerance; D051381:Rats; D013045:Species Specificity; D013385:Succinate Dehydrogenase / Q000097:blood*
D003037:Cobalt Radioisotopes; D013385:Succinate Dehydrogenase; D010100:Oxygen
Vidovye osobennosti reaktsii suktsinatdegidrogenazy limfotsitov u zhivotnykh na ostruiu gipoksicheskuiu gipoksiiu i ee sviaz' s radiorezistentnost'iu organizma.