title: Basosquamous papilloma. A benign epithelial skin tumor with multiple cytogenetic clones.
abstract: Cytogenetic analysis of short-term cultures from a basosquamous papilloma revealed the following mosaic karyotype: 46,XX,t(2;5)(q31;q31),t(8;15)(p21;q21)/46,XX,t(7;17)(p13;p13)/47,XX, t(3;20)(q12;p13),+7/46,XX,t(1:12)(p12;q13). The finding of four abnormal, cytogenetically unrelated clones suggests a multicellular origin of this benign skin tumor. None of the structural rearrangements encountered have previously been associated with neoplasia.
authors.affiliation: Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Mertens
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: Y S
authors.initials: YS
authors.lastname: Jin
authors.forename: B
authors.initials: B
authors.lastname: Johansson
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: A
authors.initials: A
authors.lastname: Biörklund
authors.forename: J
authors.initials: J
authors.lastname: Wennerberg
authors.forename: N
authors.initials: N
authors.lastname: Jonsson
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D010212:Papilloma / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*