title: Vestibulo-ocular abnormalities in spasmodic torticollis before and after botulinum toxin injections.
abstract: In order to establish whether vestibular abnormalities often found in spasmodic torticollis are secondary to the abnormal head posture, the vestibulo-ocular reflex (VOR) was studied in eight patients before and after correction of head posture with botulinum toxin. Eye movements were recorded in the dark during sinusoidal and velocity step rotation. Four patients showed a significantly asymmetric response, with the slow phase of the VOR more active ipsilateral to the torticollis (chin). Despite significant improvement of the head posture in all patients for up to 10 weeks following treatment, no correction of the vestibular asymmetry occurred. This suggests that the VOR abnormalities are not caused by the head posture itself. We interpret the findings as evidence of primary involvement of the vestibular system in torticollis and we postulate a widespread derangement of the sensory-motor mechanisms controlling head posture in this disease.
authors.affiliation: Medical Research Council Neuro-otology Unit, National Hospital for Nervous Diseases, London, UK.
authors.forename: R
authors.initials: R
authors.lastname: Stell
authors.forename: A M
authors.initials: AM
authors.lastname: Bronstein
authors.forename: C D
authors.initials: CD
authors.lastname: Marsden
mesh_terms: D000328:Adult; D001905:Botulinum Toxins / Q000008:administration & dosage*; D004584:Electronystagmography; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D012027:Reflex, Vestibulo-Ocular / Q000187:drug effects*; D013035:Spasm / Q000628:therapy; D014103:Torticollis / Q000628:therapy*; D014724:Vestibular Function Tests
chemical_list: D001905:Botulinum Toxins