title: Steady-state serum pharmacokinetics and bioequivalence of 500 mg oral versus 200 mg intravenous ciprofloxacin.
abstract: The pharmacokinetics of ciprofloxacin were examined after five days of treatment with 500 mg orally and 200 mg intravenously twice a day, in six healthy volunteers in an open, randomized crossover study. The ciprofloxacin concentrations were determined in serum by high performance liquid chromatography. The mean serum peak concentrations were obtained in 1 to 1.5 h by the oral route and the values reached were similar after the oral and intravenous dose (2.56 +/- 0.62 micrograms/ml and 2.6 +/- 0.67 micrograms/ml respectively). The terminal elimination half-life was about 4.5 h for oral form and 5 h for intravenous form. The absolute bioavailability of the oral ciprofloxacin was about 83%.
authors.affiliation: Department of Clinical Pharmacology, Faculty of Medicine, L'Archet Hospital, Nice, France.
authors.forename: R
authors.initials: R
authors.lastname: Garraffo
authors.forename: P
authors.initials: P
authors.lastname: Dellamonica
authors.forename: E
authors.initials: E
authors.lastname: Bernard
authors.forename: H
authors.initials: H
authors.lastname: Etesse
authors.forename: P
authors.initials: P
authors.lastname: Lapalus
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D013810:Therapeutic Equivalency
chemical_list: D002939:Ciprofloxacin