title: The genetics of Crohn disease: complex segregation analysis of a family study with 265 patients with Crohn disease and 5,387 relatives.
abstract: We have analysed the pedigrees of 265 probands with Crohn disease, collected from a specialty clinic at the University of Düsseldorf. Complex segregation analysis suggests the presence of a recessive gene with incomplete penetrance for susceptibility to the disease with no residual causes of family resemblance. However, a proportion of the isolated cases are probably due to phenocopies, this proportion being greatest among cases with an advanced age of onset.
authors.affiliation: Department of Dermatology, University of Düsseldorf, Federal Republic of Germany.
authors.forename: W
authors.initials: W
authors.lastname: Küster
authors.forename: L
authors.initials: L
authors.lastname: Pascoe
authors.forename: J
authors.initials: J
authors.lastname: Purrmann
authors.forename: S
authors.initials: S
authors.lastname: Funk
authors.forename: F
authors.initials: F
authors.lastname: Majewski
mesh_terms: D002874:Chromosome Mapping; D003424:Crohn Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005808:Genes, Recessive; D005860:Germany, West; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype