The slow inward calcium current is responsible for a part of the contraction of patch-clamped rat myoballs.
The slow inward calcium current and the contractile response were simultaneously recorded in voltage clamped (whole cell patch clamp recording) rat myoballs in primary culture. The shape of the contraction(T)/potential(V) relationship and the application of the inorganic calcium channel blocker cadmium (1.5 mM), which suppresses a part of the contractile activity, demonstrate the existence of two components of contraction. One of them is related to the slow calcium current.
Rivet
M
M
Laboratory of General Physiology, CNRS U.A. 290, University of Poitiers, France.
Cognard
C
C
Raymond
G
G
D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D019256:Cadmium Chloride; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D004553:Electric Conductivity; D008564:Membrane Potentials / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000166:cytology; D051381:Rats
D002104:Cadmium; D019256:Cadmium Chloride; D002118:Calcium