title: Stability of vinca alkaloid anticancer drugs in three commonly used infusion fluids.
abstract: The chemical stabilities of the vinca alkaloid anticancer drugs vinblastine, vincristine, and vindesine have been studied in three commonly used infusion fluids at 4 and 25 degrees C. The infusion fluids were: 0.9% sodium chloride, 5% dextrose, and Ringer's Lactate injection. Stability has been measured by using a stability-indicating high performance liquid chromatographic assay with ultraviolet detection. At 4 degrees C no significant degradation of the vinca alkaloids occurred within a storage period of three weeks. The stability tests at 25 degrees C also revealed that vinblastine, vincristine, and vindesine are stable (greater than 95% remained) when stored for three weeks at this temperature in 5% dextrose, 0.9% sodium chloride, or Ringer's Lactate infusion fluids.
authors.forename: J H
authors.initials: JH
authors.lastname: Beijnen
authors.forename: D E
authors.initials: DE
authors.lastname: Vendrig
authors.forename: W J
authors.initials: WJ
authors.lastname: Underberg
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D007263:Infusions, Parenteral; D012996:Solutions; D014748:Vinca Alkaloids
chemical_list: D012996:Solutions; D014748:Vinca Alkaloids