Distribution of alpha-aminoisobutyric acid in tissues of lean and genetically obese mice.
Distribution of tracer amounts of the nonmetabolizable neutral amino acid alpha-[1-14C]aminoisobutyric acid (AIB) between blood and several tissues was measured in lean and ob/ob mice over an 8-hr period. As AIB was injected on the basis of body weight and as ob/ob mice have a relatively low blood volume, absolute concentrations of AIB in blood and tissues were almost always higher in the obese than the lean mice. However, the ratio of AIB concentration in the tissues to that in the blood was clearly higher in skeletal muscle, diaphragm, and brain, and possibly higher in liver of the lean than of the obese animals. Ratios in heart were similar. The results suggest that lean and genetically obese mice differ in their capacity to transport amino acids between blood and various tissues.
Tews
J K
JK
Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison 53706.
Harper
A E
AE
D000621:Aminoisobutyric Acids / Q000378:metabolism* / Q000493:pharmacokinetics; D000818:Animals; D001921:Brain / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009765:Obesity / Q000378:metabolism*; D014018:Tissue Distribution
D000621:Aminoisobutyric Acids; C100049:2-aminoisobutyric acid