Effects of membrane acting-drugs on plasmodium species and sickle cell erythrocytes.
The effects of several membrane-acting drugs on malaria and sickle cell anemia was studied. In the initial experiments, propranolol and W-7 were shown to increase red cell density. In vitro, these drugs inhibited the growth of P. falciparum. However, in vivo experiments using the murine malarial parasite, P. vinckei, demonstrated little, if any, anti-parasite activity with the doses of drugs employed. Subsequently, prostaglandin oligomeric derivatives were found to inhibit the growth of P. falciparum in vitro and P. vinckei in vivo. Since prostaglandin oligomers inhibited the formation of dense, dehydrated cells (irreversible sickle cells), they may also have therapeutic efficacy in sickle cell anemia.
Ohnishi
S T
ST
Membrane Research Institute, Philadelphia, PA 19104.
Sadanaga
K K
KK
Katsuoka
M
M
Weidanz
W P
WP
D000527:Alprostadil / Q000031:analogs & derivatives*; D000755:Anemia, Sickle Cell / Q000188:drug therapy / Q000503:physiopathology*; D000818:Animals; D001399:Azure Stains; D002462:Cell Membrane / Q000187:drug effects; D002499:Centrifugation, Density Gradient; D004912:Erythrocytes / Q000187:drug effects*; D008288:Malaria / Q000188:drug therapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010963:Plasmodium falciparum / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology*; D011453:Prostaglandins / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology*
D001399:Azure Stains; D011453:Prostaglandins; D013449:Sulfonamides; C060276:MR 356; C017967:W 7; D011433:Propranolol; D000527:Alprostadil