Effect of captopril on urinary excretion of prostaglandins and renin-angiotensin-aldosterone system in normal subjects.
The effect of captopril on urinary excretion of prostaglandin E2, 6-keto prostaglandin F1 alpha, thromboxane B2 and renin-angiotensin-aldosterone system was studied in 13 healthy volunteers during normal and low sodium diet. Angiotensin converting enzyme inhibition led to marked increase in plasma renin activity during both dietary periods without significant modification of plasma aldosterone during normal sodium diet. Prostaglandin E2 significantly increased after captopril during both sodium intakes. Captopril did not change significantly urinary excretion of 6-keto prostaglandin F1 alpha and thromboxane B2. The results indicate that the hypotensive response to captopril in normal subjects is related to the state of sodium balance. Although renin-angiotensin-aldosterone system is the major contributor to this response, it is possible that prostaglandin E2 mediates at least partly the hypotensive and diuretic response to captopril.
Zacharieva
S
S
Institute of Endocrinology and Gerontology, Medical Academy, Sofia.
Koev
D
D
Andonova
K
K
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D004039:Diet, Sodium-Restricted; D015232:Dinoprostone / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D011453:Prostaglandins / Q000652:urine*; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*; D013929:Thromboxane B2 / Q000378:metabolism
D011453:Prostaglandins; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D002216:Captopril; D012083:Renin; D015232:Dinoprostone