Antagonism of central and peripheral anorectic effects of caerulein by L-364,718.
The reduction in food intake induced by i.p. injections of the cholecystokinin (CCK) analogue caerulein was antagonised by a low dose (0.25 mumol/kg s.c.) of the selective CCK antagonist L-364,718. To block the anorectic effect of centrally administered caerulein a dose of 25 mumol/kg of L-364,718 was required, demonstrating that central CCK receptors can be blocked effectively in the rat by choosing appropriate doses of L-364,718.
Leighton
G E
GE
Parke-Davis Research Unit, Addenbrookes Hospital Site, Cambridge, U.K.
Griesbacher
T
T
Hill
R G
RG
Hughes
J
J
D000818:Animals; D001067:Appetite Depressants / Q000037:antagonists & inhibitors*; D001570:Benzodiazepinones / Q000494:pharmacology*; D002108:Ceruletide / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D020109:Devazepide; D004435:Eating / Q000187:drug effects; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats
D001067:Appetite Depressants; D001570:Benzodiazepinones; D002108:Ceruletide; D002766:Cholecystokinin; D020109:Devazepide