[Changes in quantitative characteristics of mitochondria of the cortical tubules of the kidneys with compensatory hypertrophy in the blocking of autonomic mediation].
To elucidate the significance of neuromediators in ergotrophic provision of duct cells of the compensatory-hypertrophying kidney mitochondrial apparatuses of cortical nephron segments epithelium in a single kidney of Wistar rats have been morphometrically studied under conditions of continuous 90-day blockade of vegetative nerves by administration of both guanetidine and atropine. It is shown that distal duct mitochondria have undergone the most pronounced regressive changes in the experimental series that is accounted for by specificity and power capacity of the transport processes in this segment. Lagging of the principal morpho-functional mitochondrial characteristics in other cortical nephron portions behind those of a single kidney is a direct evidence of the active trophic influence of the vegetative nervous system mediators on adaptive reconstruction of compensatory-hypertrophying kidney metabolism.
Barinov
E F
EF
Kot
A G
AG
D000818:Animals; D001285:Atropine; D001341:Autonomic Nervous System / Q000187:drug effects*; D006145:Guanethidine; D006984:Hypertrophy; D007684:Kidney Tubules / Q000648:ultrastructure*; D007686:Kidney Tubules, Distal / Q000294:innervation / Q000473:pathology / Q000648:ultrastructure*; D007687:Kidney Tubules, Proximal / Q000294:innervation / Q000473:pathology / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure*; D009392:Nephrectomy; D009407:Nerve Block; D051381:Rats; D011919:Rats, Inbred Strains
D001285:Atropine; D006145:Guanethidine
Izmeneniia kolichestvennykh kharakteristik mitokhondriĭ kortikal'nykh kanal'tsev kompensatorno gipertrofiruiushcheĭsia pochki v usloviiakh narusheniia vegetativnoĭ mediatsii.