Genotoxicity testing: phage T7 inactivation test of various furan and arenofuran derivatives.
The genotoxic activities of 28 furan and arenofuran derivatives were tested by the phage T7-inactivation test. The genotoxic activity of the compounds was characterized quantitatively. All the compounds studied have pronounced genotoxic activities in our system. Empirical rules relating structure to genotoxic activity were found. Data obtained with our system were compared with the results of other biological systems (Salmonella assay, SOS Chromotest, CHO/HGPRT, gene amplification) in the case of some compounds included as references.
Ronto
G
G
Institute of Biophysics, Semmelweis Medical University, Budapest, Hungary.
Fekete
A
A
Grof
P
P
Bilger
C
C
Buisson
J P
JP
Tromelin
A
A
Demerseman
P
P
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D005663:Furans / Q000633:toxicity*; D005784:Gene Amplification; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D007700:Kinetics; D009152:Mutagenicity Tests; D009154:Mutation; D013014:SOS Response, Genetics / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D013604:T-Phages / Q000187:drug effects* / Q000254:growth & development; D014775:Virus Activation / Q000187:drug effects
D005663:Furans; D007041:Hypoxanthine Phosphoribosyltransferase