title: Predictive value of cone margins and post-cone endocervical curettage with residual disease in subsequent hysterectomy.
abstract: In 51 of 106 patients (48%) residual disease was identified in hysterectomy specimens performed following cervical conization. Invasive squamous cell carcinoma was found in one patient in spite of clear cone margins. Thirty-nine of sixty-three patients (62%) with cervical intraepithelial neoplasia (CIN) involving the inner (endocervical) margin of the cone biopsy had residual disease. When both the inner margin and post-cone endocervical curettage (ECC) were involved, residual disease was present in 24 of 30 (80%) hysterectomy specimens. When the inner margins of the cone were involved with CIN-III and the post-cone ECC was negative, 36% of hysterectomy specimens contained residual disease compared to 88% when post-cone ECC was positive. These findings indicate that post-cone endocervical curettage has significant predictive value with respect to the presence or absence of residual disease in patients with CIN involving the inner margins of the cervical cone.
authors.affiliation: Department of Obstetrics and Gynecology, University of Cincinnati Medical Center, Ohio 45267-0526.
authors.forename: N
authors.initials: N
authors.lastname: Husseinzadeh
authors.forename: I
authors.initials: I
authors.lastname: Shbaro
authors.forename: T
authors.initials: T
authors.lastname: Wesseler
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery; D002584:Cervix Uteri / Q000473:pathology* / Q000601:surgery; D003475:Curettage; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D011237:Predictive Value of Tests; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery