title: Physical characterization of the methanol solvate of urapidil.
abstract: The methanol solvate of urapidil was prepared and characterized by means of differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, X-ray powder diffraction, intrinsic dissolution rate, and solution calorimetry. The stoichiometry of the urapidil:methanol solvate was found to be 1:1. The crystal and molecular structures were determined from three-dimensional X-ray data. The stability of the solvate under different storage conditions was also determined.
authors.affiliation: Research Institute for Industrial Pharmacy, Potchefstroom University for C.H.E., South Africa.
authors.forename: S A
authors.initials: SA
authors.lastname: Botha
authors.forename: M R
authors.initials: MR
authors.lastname: Caira
authors.forename: J K
authors.initials: JK
authors.lastname: Guillory
authors.forename: A P
authors.initials: AP
authors.lastname: Lötter
mesh_terms: D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006860:Hydrogen Bonding; D000432:Methanol; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D008968:Molecular Conformation; D010879:Piperazines / Q000032:analysis*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D010879:Piperazines; C015568:urapidil; D000432:Methanol