title: Evaluation of vitamin D metabolism in patients with bilateral sensorineural hearing loss.
abstract: The possible role of vitamin D in hearing impairment was investigated by the measurement of three metabolites of vitamin D in 28 patients with bilateral sensorineural hearing loss (BSNHL). Twenty-three of 28 patients showed a significantly decreased level of 1,25-dihydroxyvitamin D3, with a normal value of 25-hydroxyvitamin D3. In addition to experimental and clinical reports regarding vitamin D deficiency, the present study suggests that vitamin D deficiency is one of the etiologies of BSNHL, through the calcium metabolism and microcirculation in the cochlea.
authors.affiliation: Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Z
authors.initials: Z
authors.lastname: Itoh
authors.forename: J
authors.initials: J
authors.lastname: Kusakari
authors.forename: T
authors.initials: T
authors.lastname: Takasaka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000378:metabolism; D002648:Child; D005260:Female; D006312:Hearing Loss, Bilateral / Q000209:etiology / Q000378:metabolism; D006319:Hearing Loss, Sensorineural / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014807:Vitamin D / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000150:complications
chemical_list: D014807:Vitamin D; D002117:Calcitriol; D002112:Calcifediol; D002118:Calcium