Vitamin K-dependent coagulation parameters during the first six days of life: incidence of PIVKA II in newborns.
The vitamin K-dependent carboxylation of the prothrombin precursor PIVKA II (protein induced by vitamin K absence analogous to Factor II) is essential for the synthesis of prothrombin. The noncarboxylated precursor is found in peripheral blood in the presence of vitamin K deficiency. In this study prothrombin time, Factor II and Factor VII activity, and PIVKA II were investigated in 57 newborns without vitamin K prophylaxis in order to assess their vitamin K status. Two-dimensional immunoelectrophoresis demonstrated the presence of PIVKA II in 21% of the newborns, predominantly on the second day. The PIVKA-II positive group showed significantly lower prothrombin times than the PIVKA II-negative group. An oral dose of 3 mg vitamin K (Konakion) was administered to 35 healthy newborns in a second group with the first feeding. On the second day of life, these infants showed significantly higher vitamin K-dependent laboratory parameters than the group not given vitamin K; only 9% of the treated infants were positive for PIVKA II.
Boos
J
J
Department of Pediatrics, University of Münster, F.R.G.
Pollmann
H
H
Dominick
H C
HC
D015415:Biomarkers; D005167:Factor VII / Q000032:analysis; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn / Q000097:blood* / Q000254:growth & development; D011498:Protein Precursors / Q000032:analysis*; D011516:Prothrombin / Q000032:analysis*; D011517:Prothrombin Time; D012016:Reference Values; D014812:Vitamin K / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D014813:Vitamin K Deficiency / Q000378:metabolism
D015415:Biomarkers; D011498:Protein Precursors; D014812:Vitamin K; C008208:acarboxyprothrombin; D005167:Factor VII; D011516:Prothrombin