title: A self-tuning Smith predictor applied to the control of blood pressure: simulation studies.
abstract: Significant time-delays occur in the response of blood pressure to drug therapy. The classical Smith predictor algorithm used to eliminate such delays is extended here to the principle of self-tuning under mis-match conditions. Two delay-free controller algorithms are investigated, being a self-tuning pole-placement and a self-tuning PID structure. Extensive simulation studies using the well-known Slate model have demonstrated the good transient performance obtained with this self-tuning Smith principle in various combinations, and under realistic variability of patient dynamics.
authors.affiliation: Department of Control Engineering, University of Sheffield, U.K.
authors.forename: N E
authors.initials: NE
authors.lastname: Mansour
authors.forename: D A
authors.initials: DA
authors.lastname: Linkens
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004360:Drug Therapy, Computer-Assisted; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008432:Mathematical Computing; D013813:Therapy, Computer-Assisted