title: Eosinophil responses in sheep selected for high and low responsiveness to Trichostrongylus colubriformis.
abstract: A breeding programme, based on selection for faecal egg counts, has produced lines of sheep which demonstrate either increased resistance (high responder) or susceptibility (low responder) to challenge infection with T. colubriformis after vaccination with irradiated larvae. Circulating blood eosinophilia, a hallmark of helminth infections, was examined in third generation lambs from two separate selective matings and random bred control lambs. Numbers of eosinophils were higher in high responder lambs when compared to low responders after vaccination and challenge infections. Analysis of eosinophil counts confirmed a strong line effect and there was no evidence of a sex effect. Random bred lambs showed wide individual variations in eosinophil numbers and their response to infection. It was concluded that peripheral eosinophilia was more a measure of host responsiveness to infection than an indicator of helminthiasis. As such the eosinophil may serve as an indicator of the hosts ability to respond to T. colubriformis vaccination and infection.
authors.forename: H J
authors.initials: HJ
authors.lastname: Dawkins
authors.forename: R G
authors.initials: RG
authors.lastname: Windon
authors.forename: G K
authors.initials: GK
authors.lastname: Eagleson
mesh_terms: D000818:Animals; D004198:Disease Susceptibility; D004802:Eosinophilia / Q000276:immunology / Q000662:veterinary*; D005260:Female; D007113:Immunity, Innate; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D012737:Sex Factors; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology*; D014252:Trichostrongyloidiasis / Q000662:veterinary*; D014253:Trichostrongylosis / Q000276:immunology / Q000662:veterinary*