Assignment of the human intestinal Na+/glucose cotransporter gene (SGLT1) to the q11.2----qter region of chromosome 22.
The chromosomal location of the human intestinal Na+/glucose cotransporter gene (SGLT1) was determined using human cDNA and genomic probes for this transporter gene. Southern blot analysis of genomic DNA from 15 mouse-human somatic cell hybrids showed that the human gene for this transporter resides on chromosome 22. Analysis of hamster-human hybrids selectively retaining chromosome 22 or a portion of it allowed specific assignment of the locus to the q11.2----qter region of chromosome 22. A restriction fragment length polymorphism was identified with EcoRI.
Hediger
M A
MA
Department of Physiology, UCLA School of Medicine 90024-1751.
Budarf
M L
ML
Emanuel
B S
BS
Mohandas
T K
TK
Wright
E M
EM
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22 / Q000648:ultrastructure; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009004:Monosaccharide Transport Proteins / Q000235:genetics*
D009004:Monosaccharide Transport Proteins