Synthesis and antiinflammatory/analgesic activities of N-heterocyclic carboxamides of thiopyrano-1,2-benzothiazine.
We report the synthesis of N-heterocyclic carboxamides of 5-methyl-4-oxo-2,3,4,5-tetrahydrothiopyrano [3,2-c][1,2]benzothiazine 6,6-dioxide, their antiinflammatory and analgesic activities and the attempts to obtain a corresponding sulfoxidate series. Compounds (II c) and (II l) showed a good antiinflammatory activity which is comparable to that of piroxicam. No compound showed any significant analgesic activity.
Schiaffella
F
F
Istituto di Chimica Farmaceutica, Università di Perugia.
Fringuelli
R
R
Cecchetti
V
V
Fravolini
A
A
Bruni
G
G
Runci
F M
FM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D010084:Oxidation-Reduction; D010894:Piroxicam / Q000494:pharmacology; D011714:Pyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D013440:Sulfides / Q000138:chemical synthesis / Q000494:pharmacology; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006571:Heterocyclic Compounds; D011714:Pyrans; D013440:Sulfides; D013843:Thiazines; D010894:Piroxicam