Ticarcillin/clavulanic acid versus clindamycin and gentamicin in the treatment of post-cesarean endometritis following antibiotic prophylaxis.
One hundred fifty-two women who received cefazolin prophylaxis and subsequently developed postpartum endometritis were randomized to treatment with either ticarcillin/clavulanic acid (75) or clindamycin-gentamicin (77). Bacteria isolated from the endometrium were predominantly facultative anaerobic bacteria. The ratio of facultative anaerobes to obligate anaerobes was 3:1. Nineteen percent of the women were bacteremic, with mycoplasma the organism most frequently isolated from venous blood specimens. Cure rates were similar for both groups: ticarcillin/clavulanic acid 85% and clindamycin-gentamicin 81%. The advantages of ticarcillin/clavulanic acid are an increased spectrum of activity against beta-lactamase-producing bacteria, less toxicity, and lower cost.
Faro
S
S
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
Martens
M
M
Hammill
H
H
Phillips
L E
LE
Smith
D
D
Riddle
G
G
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002585:Cesarean Section / Q000009:adverse effects; D002969:Clavulanic Acids / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004716:Endometritis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D011247:Pregnancy; D011645:Puerperal Infection / Q000188:drug therapy*; D011897:Random Allocation; D013982:Ticarcillin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D005839:Gentamicins; D002981:Clindamycin; D013982:Ticarcillin