title: Tallow and the time capsule: Claude Bernard's discovery of the pancreatic digestion of fat.
abstract: In 1848, Claude Bernard discovered that pancreatic secretion could emulsify and saponify fatty substances. He would eventually attribute these reactions to an enzyme that was later named 'pancreatic lipase'. This essay has three goals: 1) to examine Bernard's previously overlooked research on the pancreas; 2) to explore the equally ignored history of lipid digestion and metabolism; 3) to reconstruct Bernard's discovery of pancreatic lipase through a parallel analysis of his laboratory notebooks and his publications. This method reveals a discrepancy between the sequence and motivation of events as they were reported by Bernard in his publications and as they appear in his laboratory notebooks.
authors.forename: A C
authors.initials: AC
authors.lastname: de Romo
mesh_terms: D000818:Animals; D004063:Digestion; D005223:Fats / Q000266:history*; D049672:History, 19th Century; D006801:Humans; D050356:Lipid Metabolism; D010179:Pancreas / Q000378:metabolism*; D010827:Physiology / Q000266:history*
chemical_list: D005223:Fats