title: Idiopathic Heinz body hemolytic anemia in newborn infants.
abstract: Heinz body hemolytic anemia developed in six full-term infants while at home during the first 2 weeks of life. The disorder first manifested as hyperbilirubinemia. However, in all cases, severe anemia (hemoglobin concentration 49-73 g/L) developed during the 4-12 days of hospitalization. The infants had not been exposed to known oxidants, and their erythrocytes were not glucose-6-phosphate dehydrogenase (G6PD) deficient and contained no unstable hemoglobin. It is hypothesized that in these newborn infants, Heinz body hemolytic anemia developed as a result of ingestion of an oxidant contained in feedings. The nature of this agent is as yet unknown.
authors.affiliation: Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Ballin
authors.forename: E J
authors.initials: EJ
authors.lastname: Brown
authors.forename: A
authors.initials: A
authors.lastname: Zipursky
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology* / Q000628:therapy; D004912:Erythrocytes / Q000648:ultrastructure; D006366:Heinz Bodies; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology* / Q000628:therapy; D008297:Male