Comparison of chlortenoxicam and indomethacin on frusemide-induced diuresis.
A single oral dose of chlortenoxicam 4 mg, a new non-steroidal anti-inflammatory drug, significantly antagonized the diuretic and natriuretic actions of frusemide when compared with placebo in normal human volunteers. Indomethacin 50 mg significantly reduced the natriuretic, but not diuretic action of frusemide.
Hitoglou-Makedou
A
A
Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK.
Lawson
M
M
Turner
P
P
Ferber
H P
HP
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D005665:Furosemide / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000494:pharmacology; D010919:Placebos; D011188:Potassium / Q000652:urine; D016032:Randomized Controlled Trials as Topic; D012964:Sodium / Q000652:urine; D014556:Urine
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010919:Placebos; D010894:Piroxicam; D005665:Furosemide; D012964:Sodium; C059451:lornoxicam; D011188:Potassium; D007213:Indomethacin