[The effect of diltiazem manufactured by Lachema on the calcium paradox in the isolated rat heart].
The calcium paradox known as irreversible damage of the metabolism, structure, and function of the heart was used as model for testing the efficacy of diltiazem (Lachema) in the concentrations of 0.4 and 4.0 mumol.l-1. On the isolated rat heart perfused by Langendorff's method, the calcium paradox induced by 2.5 min depletion and subsequent 10 min repletion of calcium was manifested by loss of electric and contractile activity, by drop of coronary flow, and by significant decrease of ATP and ADP content, as well as of the total content of adenine nucleotides in the tissue. Diltiazem (Lachema) in the tested concentrations of 0.4 and 4.0 mumol.l-1 effectively reduced the damage of cardiac function. Its effect was demonstrated by improvement of the hemodynamic and metabolic parameters studied.
Ravingerová
T
T
Ziegelhöffer
A
A
Tribulová
N
N
Slezák
J
J
Okolicány
J
J
D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D004110:Diltiazem / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D051381:Rats; D011919:Rats, Inbred Strains
D004110:Diltiazem; D002118:Calcium
Ovplyvnenie vápnikového paradoxu v izolovanom srdci potkana diltiazemom Lachema.