Influence of adrenalectomy on the development of the neonatal thymus in the rat.
Adrenalectomy of 1-, 6-, 11- and 16-day-old male and female rats did not cause any changes in the weight of thymus 5 days later. Adrenalectomy on days 21, 26, 31 and 81 of age induced a significant hypertrophy of the thymus 5 days later. These results indicate that after about the time of weaning, the thymus is under some inhibitory regulation by the adrenal gland.
Inomata
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Department of Laboratory Animal Science, Azabu University, School of Veterinary Medicine, Kanagawa, Japan.
Nakamura
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D000315:Adrenalectomy; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight; D005260:Female; D006984:Hypertrophy; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012737:Sex Factors; D013950:Thymus Gland / Q000254:growth & development* / Q000473:pathology