Hand-mirror (HM) cells in acute lymphoblastic leukaemia (A.L.L.). An attempt at cellular classification by morphometric analytical parameters using the S.A.M. (Shape Analytical Morphometry) system.
A morphometric study of the nuclear and cytoplasmic shape of a blastic population in a case of HM-A.L.L. was performed by comparing the two differently shaped populations with and without HM configuration. The results obtained using analytical size-independent parameters created by the S.A.M. work-station enable us to characterize the shape of both blastic cell populations quantitatively, and strongly suggest the existence of shape modulation from one cellular type toward the other. Thus a possible sequence from blastic cells (having regular, rather round nuclei) to HM cells (characterized by high distortion of both nucleus and cytoplasm) was proposed.
Ricco
R
R
Institute of Pathological Anatomy, Haematology, University of Bari, Italy.
Liso
V
V
Specchia
G
G
Pavone
V
V
Marzano
N
N
Lettini
T
T
Pesce Delfino
V
V
Pennella
A
A
D002467:Cell Nucleus / Q000473:pathology; D003584:Cytological Techniques; D003593:Cytoplasm / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*