Role of 99mTc-disofenin in duodenal and gastric aspirates in the evaluation of persistent neonatal cholestasis.
A prospective study was undertaken on 49 infants with prolonged neonatal cholestasis to determine whether the specificity, sensitivity, and accuracy of 99mTc-disofenin scintigraphy can be improved by performing simultaneous radioactivity measurements on duodenal and gastric aspirates along with routine imaging. Specificity of routine scintigraphy was improved by this modification from 45.7 to 76.4%. Accuracy of the test was also superior in improving from 55% with routine scintigraphy to 78.4% by counting additional radioactivity on both duodenal and gastric aspirates. We suggest that this modified technique be applied in the evaluation of infants with conjugated hyperbilirubinemia so that invasive procedures such as open liver biopsy and operative cholangiogram may be avoided.
Tolia
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G.I. Procedure Unit, Children's Hospital of Michigan, Wayne State University, Detroit 48201.
Kuhns
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Dubois
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RS
D004386:Duodenum / Q000000981:diagnostic imaging*; D005750:Gastric Juice / Q000000981:diagnostic imaging*; D006801:Humans; D007098:Imino Acids; D007223:Infant; D007231:Infant, Newborn; D007419:Intestinal Secretions / Q000000981:diagnostic imaging*; D007567:Jaundice, Neonatal / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D019785:Technetium Tc 99m Disofenin
D007098:Imino Acids; D015609:Organotechnetium Compounds; D019785:Technetium Tc 99m Disofenin