Microbial influences on urinary polyamine excretion.
We determined diamines, polyamines, their monoacetylated conjugates and some of their catabolites in urines of healthy persons during decontamination of the gastrointestinal tract and patients with urinary tract infections. The compounds were also measured after in vitro incubation of urines from healthy persons and patients. During decontamination the urinary excretion of total putrescine decreased by a small amount. This fall was for the greater part accountable to monoacetylated putrescine. Free putrescine levels were increased in urines of patients with urinary tract infections, decreased after therapy, and increased after incubation of the pretherapeutical samples. Total cadaverine decreased during decontamination and increased during recontamination. The changes were partly accountable to monoacetylated cadaverine. Free cadaverine levels of patients with urinary tract infections were normal and did not change after therapy. These data show that, under normal conditions, a small part of monoacetylated putrescine and a considerable part of monoacetylated cadaverine originate from the gastrointestinal tract, and that urinary tract infections lead to an increase of free putrescine. The microbial synthesis of putrescine in the gastrointestinal- and urinary tracts, should therefore be taken into account for the interpretation of urinary putrescine levels as a parameter for body cell turnover.
Satink
H P
HP
Central Laboratory for Clinical Chemistry, University Hospital University of Groningen, The Netherlands.
Hessels
J
J
Kingma
A W
AW
van den Berg
G A
GA
Muskiet
F A
FA
Halie
M R
MR
D000328:Adult; D001419:Bacteria / Q000187:drug effects; D002509:Cephaloridine / Q000494:pharmacology; D004064:Digestive System / Q000382:microbiology*; D006801:Humans; D011073:Polyamines / Q000652:urine*; D011112:Polymyxin B / Q000494:pharmacology; D014552:Urinary Tract Infections / Q000382:microbiology / Q000652:urine*
D011073:Polyamines; D011112:Polymyxin B; D002509:Cephaloridine