Failure to induce neoplasia in nude mice by injection of disrupted cells from continuous cell lines.
Nude mice were injected subcutaneously with disrupted cells from three continuous cell lines (HeLa, NCTC clone 2472 and Morris hepatoma). No tumours were observed at either the inoculation site or in other organs taken at 35 or 90 days after injection. Live cells from one line (HeLa) produced tumours at the inoculation site after eight to 12 days.
Wood
G W
GW
Central Veterinary Laboratory, Weybridge, Surrey.
Drury
S E
SE
Done
S H
SH
Thornton
D H
DH
D000818:Animals; D006367:HeLa Cells; D008114:Liver Neoplasms, Experimental; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured