Histopathological studies on experimental marine toxin poisoning--III. Morphological changes in the liver and thymus of male ICR mice induced by goniodomin A, isolated from the dinoflagellate Goniodoma pseudogoniaulax.
The i.p. LD50 values of goniodomin A, a novel polyether macrolide, in male ICR mice were 1.2 and 0.7 mg/kg at 24 and 48 hr, respectively. Histologically, perihepatitis, non-fatty vacuoles in the hepatocytes, central necrosis of the liver and massive necrosis of lymphocytes, in the cortical layer of the thymus, were prominent.
Terao
K
K
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Ito
E
E
Murakami
M
M
Yamaguchi
K
K
D000818:Animals; D004141:Dinoflagellida / Q000378:metabolism*; D004987:Ethers / Q000506:poisoning*; D008099:Liver / Q000473:pathology*; D018942:Macrolides; D008297:Male; D008387:Marine Toxins / Q000506:poisoning*; D051379:Mice; D008813:Mice, Inbred ICR; D013950:Thymus Gland / Q000473:pathology*
D004987:Ethers; D018942:Macrolides; D008387:Marine Toxins; C059668:goniodomin A