Antigenical alterations of hepatocyte membrane in rats after long-term administration of ethanol and carbon tetrachloride.
The presence of IgG over the hepatocyte's surfaces in ethanol- and/or carbon tetrachloride-pretreated rats was demonstrated as a very thin lineal fluorescent deposition around the membrane. The percentage of parenchymal IgG-positive liver cells ranged between 15 and 100% in all animals of treated groups. This suggests that ethanol may induce hepatic injury mediated by IgG autoantibodies which may be a response to an antigenical determinant present in hepatocytes altered by ethanol and/or carbon tetrachloride treatment.
Parafita
M A
MA
Department of Physiology, University of Santiago de Compostela, Spain.
Pazo
J A
JA
Alfonso
M
M
Beiras
E
E
D000437:Alcoholism / Q000276:immunology*; D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D002252:Carbon Tetrachloride Poisoning / Q000276:immunology*; D002462:Cell Membrane / Q000187:drug effects / Q000276:immunology; D004334:Drug Administration Schedule; D007074:Immunoglobulin G / Q000032:analysis*; D008099:Liver / Q000187:drug effects* / Q000276:immunology / Q000648:ultrastructure; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001323:Autoantibodies; D007074:Immunoglobulin G