Identification of and changes in the expression of troponin T isoforms in developing avian and mammalian heart.
Immunochemical studies have shown the presence of a single isoform of troponin T, the adult form, in all chambers of adult chicken and rat hearts. An additional isoform, the embryonic form, was detected during early development of the cardiac muscle. As the amount of adult isoform increased, the embryonic form decreased and was finally suppressed during early post-natal or post-hatch period. The replacement of the embryonic isoform by the adult form appeared slower in the atrium than in the ventricle. While the adult isoform of troponin T was not detected until late in gestation in the rat heart, this isoform of troponin T was present in the chicken heart even at 4 days in ovo.
Sabry
M A
MA
Department of Immunology, Medical School, University of Birmingham, UK.
Dhoot
G K
GK
D000818:Animals; D000911:Antibodies, Monoclonal; D002642:Chick Embryo; D002645:Chickens; D006321:Heart / Q000254:growth & development; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D014336:Troponin / Q000276:immunology / Q000378:metabolism*; D020107:Troponin T
D000911:Antibodies, Monoclonal; D014336:Troponin; D020107:Troponin T