In vivo anaphylaxis in the rat: effects of phosphodiesterase inhibitors.
On the basis of their inhibitory capacities on the phosphodiesterase enzyme system, we studied the anti-anaphylactic effect of milrinone and sulmazole in comparison with theophylline. For this purpose anaphylactic shock was induced in actively sensitised, spontaneously breathing rats. Milrinone, sulmazole and theophylline reduced anaphylactic bronchoconstriction without affecting the antigen induced fall in blood pressure. Surprisingly, sulmazole reduced mortality significantly.
Post
M J
MJ
Department of Pharmacotherapy, Faculty of Pharmacy, University of Ultrecht, The Netherlands.
te Biesebeek
J D
JD
Wemer
J
J
van Rooij
H H
HH
Porsius
A J
AJ
D000707:Anaphylaxis / Q000188:drug therapy*; D000818:Animals; D000941:Antigens / Q000276:immunology; D002319:Cardiovascular System / Q000187:drug effects; D007093:Imidazoles / Q000627:therapeutic use; D008168:Lung / Q000187:drug effects; D008297:Male; D020105:Milrinone; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D011728:Pyridones / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D013806:Theophylline / Q000627:therapeutic use
D000941:Antigens; D007093:Imidazoles; D010726:Phosphodiesterase Inhibitors; D011728:Pyridones; D013806:Theophylline; C029758:sulmazole; D020105:Milrinone