[Penetration of antibiotics into second degree burned skin in rabbits].
This study was designed to determine the concentration of antibiotics administered systemically in second degree burned skin in rabbits. I: Penetration of Sulfobenzyl-penicillin (SBPC) into Deep Dermal Burn (DDB). The concentration of SBPC was determined in the skin and serum of four groups. One group acted as control and the other three had DDB. The rabbits in each were administered 100 mg/kg of SBPC by 2 hour drip infusion. In burn groups SBPC was given on the 1st, 4th and 7th post burn day, respectively. In the control group, peak concentration in the serum and skin was obtained at the end of the drip administration decreasing quickly thereafter. In every burn group, SBPC was detected in the skin and peak concentration was obtained at the end of the drip administration. After drip infusion, the SBPC level in the skin remained longer in the burn groups than in the control group. In the first day burn group, SBPC could not be detected until 1 hour after the initiation of the drip, while in the other two burn groups, SBPC could be detected a little at 30 minutes. The SBPC skin to serum ratio at the end of the drip administration in each burn group was half the value of that in the control group. II: Penetration of Cefpiramide (CPM) into Superficial Dermal Burn (SDB). The concentration of CPM was determined in the skin and serum of five groups. One group acted as control and the other four had SDB. The rabbits in each group were administered 20 mg/kg of CPM intravenously by bolus injection. In burn groups CPM was given at 8, 16, 24 and 48 hours, respectively, after burn inducement. As in the control group, CPM was detected in the SDB at every stage after burn inducement. However, CPM remained in the burned skin longer than in the non-burned skin. In the 16-hour-after-burn-group the CPM level reached its peak at 30 minutes after injection, while in the other three burn groups, the maximum level was achieved at 15 minutes. The CPM concentration in the skin of each burn group was the same or higher than that of the control group. III: Antibiotics systemically administered were determined in second degree burned skin. However, the degree of penetration was different according to the degree of burn.(ABSTRACT TRUNCATED AT 400 WORDS)
Yoshida
T
T
Department of Plastic and Reconstructive Surgery, School of Medicine, Hokkaido University, Sapporo.
D000818:Animals; D002056:Burns / Q000378:metabolism*; D002511:Cephalosporins / Q000493:pharmacokinetics*; D010400:Penicillin G / Q000031:analogs & derivatives*; D011817:Rabbits; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D013408:Sulbenicillin / Q000493:pharmacokinetics*; D013997:Time Factors
D002511:Cephalosporins; C036666:cefpiramide; D013408:Sulbenicillin; D010400:Penicillin G