Arginine vasopressin mediates cardiovascular responses to hypoxemia in fetal sheep.
Acute hypoxemia results in hypertension, bradycardia, and cardiac output redistribution in fetal sheep. The blood flow redistribution is produced by differential changes in vascular resistance of various fetal organs. alpha-Adrenergic activity is one of the few vasoconstrictor mechanisms thus far identified in the hypoxemic fetal sheep. Arginine vasopressin (AVP) is a potent vasoconstrictor in adults. Since AVP administration to the normoxic fetus mimics some of the fetal cardiovascular responses to hypoxemia and fetal plasma AVP levels increase with hypoxemia, we examined the hypothesis that AVP modifies the fetal cardiovascular response to hypoxemia by changing the vascular resistance of some fetal vascular beds. To test this we determined fetal systemic arterial pressure and fetal cardiac output and its distribution during hypoxemia with and without the V1 AVP antagonist d(CH2)5-Tyr(Me)AVP. Fourteen fetal sheep (0.79-0.90 of gestation) were chronically catheterized. Five days after surgery fetal hypoxemia was induced by introducing a mixture of 95% N2-5% CO2 (10-20 l/min) into a maternal tracheal catheter. The hypoxemia was maintained for 40 min. Fetal heart rate, systemic arterial blood pressure, and combined ventricular output and its distribution (radiolabeled microspheres) were measured before hypoxemia, at 20 min of hypoxemia alone, and at 20 min of hypoxemia plus either AVP antagonist (n = 5) or NaCl 0.9% (n = 5, controls). Fetal hypertension and bradycardia were partially reversed after the AVP antagonist administration during hypoxia.(ABSTRACT TRUNCATED AT 250 WORDS)
Peréz
R
R
Departamento de Preclínicas, Facultad de Medicina, Universidad de Chile, Santiago.
Espinoza
M
M
Riquelme
R
R
Parer
J T
JT
Llanos
A J
AJ
D000136:Acid-Base Equilibrium; D000818:Animals; D001127:Arginine Vasopressin / Q000502:physiology*; D001784:Blood Gas Analysis; D001794:Blood Pressure; D002302:Cardiac Output; D002319:Cardiovascular System / Q000503:physiopathology*; D005260:Female; D005312:Fetal Blood; D006339:Heart Rate; D000860:Hypoxia / Q000503:physiopathology*; D011247:Pregnancy; D012756:Sheep
D001127:Arginine Vasopressin