Photosensitization with derivatives of chlorophyll.
The properties of several chlorophyll derivatives were examined: the methyl esters of pheophorbide A, pheophorbide B and pheophytin. In spite of structural differences, all products were equally effective sensitizers in vitro and were localized equally well by murine tumors in vivo after 1 h. But only the pheophytins persisted at neoplastic loci for 24 h. There was no evidence of hydrolysis of the methyl esters, but the phytyl ester linkage was labile in vivo.
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D000818:Animals; D002470:Cell Survival / Q000187:drug effects* / Q000528:radiation effects; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000473:pathology; D008027:Light; D051379:Mice; D011838:Radiation-Sensitizing Agents; D013050:Spectrometry, Fluorescence; D014407:Tumor Cells, Cultured / Q000166:cytology* / Q000187:drug effects / Q000528:radiation effects
D011838:Radiation-Sensitizing Agents; D002734:Chlorophyll