The effects of endothelin on renovascular resistance and renin release.
In the isolated perfused rat kidney, endothelin inhibits renin release and reduces the renal perfusate flow. The half-maximally effective concentrations were 30 and 50 pmol/l, respectively. Both effects are slow in onset and in washout. The calcium channel antagonist nimodipine (2 mumol/l) completely blocks the vasoconstrictor and renin secretion response of a median inhibitory concentration (IC50) of endothelin, indicating that entry of external calcium may play a role. Vasoconstriction and inhibition of renin release by endothelin are attenuated in the presence of a protein kinase C inhibitor, staurosporine, which suggests that protein kinase C helps to mediate the effects of endothelin on renin secretion and vascular resistance.
Münter
K
K
Department of Pharmacology, University of Heidelberg, Federal Republic of Germany.
Hackenthal
E
E
D000818:Animals; D004305:Dose-Response Relationship, Drug; D016232:Endothelins; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006869:Hydronephrosis / Q000503:physiopathology; D066298:In Vitro Techniques; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000032:analysis / Q000378:metabolism*; D014655:Vascular Resistance / Q000187:drug effects* / Q000502:physiology
D016232:Endothelins; D010455:Peptides; D012083:Renin