title: Assessment of a new device for laser angioplasty.
abstract: Experimental work has shown that a transparent laser device delivering pulsed energy to an artery results in a smaller area of surrounding damage than does an opaque device with a continuous wave laser. The combination of a transparent ball-tipped device with a pulsed Nd-YAG laser has been investigated. The system delivers pulses of 100 microseconds at a rate of 10 Hz and average energy of 0.5 J per pulse with an energy loss of 5-10% between the output at the laser rail and the fibre tip. The dose/response was measured and showed that on normal aorta under saline the device produces craters with a depth of 5 microns/J and 1.5 mm radius. There is a 100% increase in dose response with diseased aorta and a 50% increase when exposure is carried out under blood. The effect of a varying angle of incidence upon the arterial wall has been measured. Angulation of the device at 10 degrees from the perpendicular reduces the crater depth to 50%, as compared with a 50% reduction at 60 degrees using a bare fibre. As estimated with a thermal camera in air, the device heats up to a maximum of 50 degrees C during a 50 J exposure, compared to 110 degrees C after 5 J for the sapphire device. Artificial circulation experiments were carried out using diseased femoral vessels occluded by a ligature. The new system recanalised 100% of occlusion in straight vessels, and 40% of occlusions in curved vessels at a radius of 2.5 cm.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Surgery, University College, London, U.K.
authors.forename: J A
authors.initials: JA
authors.lastname: Michaels
authors.forename: F W
authors.initials: FW
authors.lastname: Cross
authors.forename: T J
authors.initials: TJ
authors.lastname: Bowker
authors.forename: S G
authors.initials: SG
authors.lastname: Bown
authors.forename: M
authors.initials: M
authors.lastname: Aita
authors.forename: G
authors.initials: G
authors.lastname: Samson
authors.forename: M
authors.initials: M
authors.lastname: Adiseshiah
authors.forename: A
authors.initials: A
authors.lastname: Marston
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology / Q000601:surgery; D001158:Arteries / Q000601:surgery*; D001161:Arteriosclerosis / Q000601:surgery; D006328:Cardiac Catheterization; D003331:Coronary Vessels / Q000601:surgery; D004285:Dogs; D004867:Equipment Design; D004869:Equipment Safety; D005263:Femoral Artery / Q000601:surgery; D005336:Fiber Optic Technology; D006358:Hot Temperature; D053685:Laser Therapy / Q000295:instrumentation*