title: Lipopolysaccharide-stimulated rat brain macrophages release NGF in vitro.
abstract: Amoeboid microglial cells purified from primary cultures of embryonic rat brains and stimulated with bacterial lipopolysaccharides released high amounts of nerve growth factor. This finding suggests that brain macrophages play a major neurotrophic role during development, in adulthood, and in the regenerative events that follow localized lesions.
authors.affiliation: INSERUM U114, Collège de France, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Mallat
authors.forename: R
authors.initials: R
authors.lastname: Houlgatte
authors.forename: P
authors.initials: P
authors.lastname: Brachet
authors.forename: A
authors.initials: A
authors.lastname: Prochiantz
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology*; D002452:Cell Count; D002460:Cell Line; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000378:metabolism*; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats
chemical_list: D008070:Lipopolysaccharides; D009414:Nerve Growth Factors