title: Clinical course and surgical prognosis of 33 cases of intracranial epidermoid tumors.
abstract: Thirty-three cases of intracranial epidermoid tumors treated during the past 25 years were analyzed with regard to clinical manifestations, recurrence rates related to the extent of surgery, and long-term survival rates. Epidermoid tumors caused various symptoms, especially in the cerebellopontine angle (15 cases), of which a transient remission of symptoms was observed in 4 cases (23.5%). The average time from initial symptoms to surgery was much shorter in suprasellar region and third ventricular locations (average of 11 months) than in other locations (average of 7 years). In 28 patients (84.9%), the tumor was removed totally or subtotally. Most of the patients could lead an independent and useful life after operation (93.1%). Among the 29 patients in a long-term follow-up survey, seven tumors recurred after an average interval of 8 years and 10 months (from the first to second operation) and 12 years and 6 months (from the second to third operation). Patients with recurrent tumors were successfully treated, and excellent functional prognosis was observed even after the second or third operation. The 20-year survival rate was 92.8% (Kaplan-Meier method).
authors.affiliation: Department of Neurosurgery, University of Tokyo Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamakawa
authors.forename: N
authors.initials: N
authors.lastname: Shitara
authors.forename: S
authors.initials: S
authors.lastname: Genka
authors.forename: S
authors.initials: S
authors.lastname: Manaka
authors.forename: K
authors.initials: K
authors.lastname: Takakura
mesh_terms: D000293:Adolescent; D000328:Adult; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D002648:Child; D004814:Epidermal Cyst / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D014057:Tomography, X-Ray Computed