Evidence for central phenomena participating in the changes of responses of ventrobasal thalamic neurons in arthritic rats.
In this study performed in the Freund's adjuvant-induced arthritic rat, a local injection of lidocaine in one hind paw strongly depressed the ventrobasal thalamic neuronal responses to mild stimulation of both ankles. In parallel, a behavioral study provided evidence for a bilateral hypoalgesia, tested by the vocalization threshold to paw pressure, after a unilateral anesthetic block. The involvement of central phenomena in the changes of neuronal responsivity described in this model of experimental pain is therefore suggested.
Guilbaud
G
G
Unité de Recherche en Physiopharmacologie du Système nerveux U 161 INSERM, Paris, France.
Benoist
J M
JM
Eschalier
A
A
Kayser
V
V
Gautron
M
M
Attal
N
N
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001168:Arthritis / Q000503:physiopathology*; D004837:Epinephrine / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013788:Thalamus / Q000503:physiopathology*
D008012:Lidocaine; D004837:Epinephrine