title: [The nuclear surface area as a malignancy parameter in breast cancer].
abstract: For better characterisation of the degree of malignancy of breast cancers, we have attempted to establish a correlation between nuclear size and prognosis in breast cancer. Karyometric investigations were carried out on biopsies from 200 primary breast cancers. On the basis of the nuclear areas determined, we were able to distinguish three groups of carcinomas: group I: carcinomas with small nuclear areas (n = 33), mean value 97.76 microns 2, group II: carcinomas with intermediate nuclear areas (n = 98), mean value of the nuclear areas 146.5 microns 2, group III: carcinomas with large nuclear areas (n = 69), mean value 190.8 microns 2. After five years, 6% of the patients in group I had died, as compared to 35% in group II and 48% in group III. The median survival time was 45 to 48 months in group I, as compared to 37 months in group II and 28 months in group III. There was a direct correlation between axillary lymph node status and nuclear size: the carcinomas with the small nuclear sizes showed the least involvement. A comparison of the prognostic relevance of nodal status and nuclear area size, reveals a good relevance for the nuclear area similar to that of the nodal status. The results of the biopsy cytology are already available to the surgeon before the operation.
authors.affiliation: Abteilung Gynäkologie und Geburtshilfe, Ketteler-Krankenhaus Offenbach.
authors.forename: H
authors.initials: H
authors.lastname: Schöndorf
authors.forename: G
authors.initials: G
authors.lastname: Bastert
authors.forename: M
authors.initials: M
authors.lastname: Löbel
authors.forename: H
authors.initials: H
authors.lastname: Naujoks
mesh_terms: D001706:Biopsy; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D002467:Cell Nucleus / Q000648:ultrastructure*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007620:Karyometry; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D015411:Mastectomy, Modified Radical
vernacular_title: Die Kernflächengrösse als Malignitätsparameter beim Mammakarzinom.