Relation between the location of elements in the periodic table and various organ-uptake rates.
Fifty four elements and 65 radioactive compounds were examined to determine the organ uptake rates for rats 3, 24 and 48 h after i.v. injection of these compounds. They were prepared as carrier free nuclides, or containing a small amount of stable nuclide. Generally speaking, behaviors of K, Rb, Cs and Tl in all the organs were very similar to one another, but they differed from that of Na. Bivalent hard acids were avidly taken up into bone; therefore, uptake rates in soft tissues were very small. Hard acids of tri-, quadri- and pentavalence which were taken up into the soft tissue organs decreased more slowly from these organs than other ions. Soft acids such as Hg2+ were bound very firmly to the component in the kidney. Anions (with few exceptions), GeCl4 and SbCl3 were rapidly excreted in urine, so that the uptake rates in organs were low.
Ando
A
A
School of Allied Medical Professions, Kanazawa University, Japan.
Ando
I
I
Hiraki
T
T
Hisada
K
K
D000818:Animals; D004602:Elements / Q000145:classification* / Q000493:pharmacokinetics; D009928:Organ Specificity; D011877:Radionuclide Imaging; D051381:Rats; D012517:Sarcoma, Yoshida / Q000000981:diagnostic imaging; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
D004602:Elements