title: Oophorectomy did not show any additional effect on bone density and mineral content in thyroxine treated mice.
abstract: Experimental hyperthyroidism (thyroxine administration for 21 days) caused a significant decrease in ash mass, bone density and mineral content in the femora of mice, the same degree of reduction in individual measures of bone mass being found in oophorectomized and intact mice treated with thyroxine. It may be suggested that estrogens did not protect the skeleton against the resorbing action of thyroxine or triiodothyronine.
authors.affiliation: Department of Internal Medicine, Medical Faculty of Charles University, Praha, Czechoslovakia.
authors.forename: P D
authors.initials: PD
authors.lastname: Broulik
authors.forename: V
authors.initials: V
authors.lastname: Pacovský
authors.forename: Z
authors.initials: Z
authors.lastname: Límanová
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006980:Hyperthyroidism / Q000378:metabolism*; D051379:Mice; D008903:Minerals / Q000378:metabolism*; D010052:Ovariectomy; D013974:Thyroxine / Q000494:pharmacology*
chemical_list: D008903:Minerals; D013974:Thyroxine