[Effect of carteolol and timolol eyedrops on the pressure tolerance of the optic nerve head].
In a planned, randomized, double blind study ocular perfusion pressures were measured before and after a 3-day regimen of 2% carteolol hydrochloride or 0.5% timolol maleate. A pressure tolerance test was also carried out. The results of this test revealed the critical pressure: it is the artificially increased intraocular pressure at which the visual function (monitored by visually evoked cortical potentials) is reduced to 20% of its initial value. The ocular perfusion pressures are affected by both drugs. They are more clearly reduced by carteolol than by timolol. The critical pressure is affected by both drugs too. After application of carteolol, the critical pressure is clearly lower than after application of timolol. The difference is statistically significant (p less than 0.05).
Stodtmeister
R
R
Universitäts-Augenklinik, Ulm, BRD.
Pillunat
L
L
Wilmanns
I
I
Neubrand
M
M
Finger
B
B
Tobias
G
G
D000222:Adaptation, Physiological / Q000187:drug effects; D000328:Adult; D002354:Carteolol / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D009883:Ophthalmic Solutions; D009898:Optic Disk / Q000187:drug effects* / Q000502:physiology; D011412:Propanolamines / Q000494:pharmacology*; D011897:Random Allocation; D013999:Timolol / Q000494:pharmacology*; D014785:Vision, Ocular / Q000502:physiology
D009883:Ophthalmic Solutions; D011412:Propanolamines; D013999:Timolol; D002354:Carteolol
Wirkung von Carteolol- und Timolol-Augentropfen auf die Drucktoleranz des Sehnervenkopfes.