[The new cerebrovascular preparation pikamilon].
Picamilon, a sodium salt of N-nicotinoyl-gamma-aminobutyric acid, was shown to induce a significant increase of cerebral blood flow in conscious cats. Picamilon was found to inhibit neurogenic spasms of cerebral vessels that was followed by suppression of tonic activity and reflectory discharges in sympathetic nerves. Picamilon led to restoration of the initial condition of cerebral hemodynamics disturbed by a previous administration of serotonin.
Mirzoian
R S
RS
Gan'shina
T S
TS
D000818:Animals; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D006439:Hemodynamics / Q000187:drug effects; D002546:Ischemic Attack, Transient / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D012701:Serotonin / Q000494:pharmacology; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology; D014980:Xenon Radioisotopes; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D014980:Xenon Radioisotopes; D012701:Serotonin; D005680:gamma-Aminobutyric Acid
Novyĭ tserebrovaskuliarnyĭ preparat pikamilon.