[Effect of a single dose of captopril on left-ventricular function in patients with chronic congestive cardiomyopathy].
In 15 patients with mild, chronic congestive heart failure the effect of a single dose of captopril (25 mg/m2 b.s.) on heart rate, systolic and diastolic blood pressure as well as on left ventricular function was studied at rest and after a submaximal physical effort. Preejection period (PEP), left ventricular ejection time (LVET) and the contractility index PEP/LVET were polycardiographically determined++. Left ventricular end diastolic volume (DVol), and systolic volume (SVol), ejection fraction (EF), stroke volume index (SVI) and cardiac index (CI) were estimated using two-dimensional echocardiography. Obtained data indicate, that in patients with chronic, congestive heart failure, a single dose of captopril lowers blood pressure at rest without significant changes of hemodynamic parameters, but improves left ventricular function during physical effort.
Markiewicz
K
K
Górski
L
L
Cholewa
M
M
Dryjański
T
T
Bratkowska
B
B
D000328:Adult; D002216:Captopril / Q000008:administration & dosage*; D002302:Cardiac Output / Q000187:drug effects* / Q000502:physiology; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D005260:Female; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology
D002216:Captopril
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