Physical characterization of the methanol solvate of urapidil.
The methanol solvate of urapidil was prepared and characterized by means of differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, X-ray powder diffraction, intrinsic dissolution rate, and solution calorimetry. The stoichiometry of the urapidil:methanol solvate was found to be 1:1. The crystal and molecular structures were determined from three-dimensional X-ray data. The stability of the solvate under different storage conditions was also determined.
Botha
S A
SA
Research Institute for Industrial Pharmacy, Potchefstroom University for C.H.E., South Africa.
Caira
M R
MR
Guillory
J K
JK
Lötter
A P
AP
D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006860:Hydrogen Bonding; D000432:Methanol; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D008968:Molecular Conformation; D010879:Piperazines / Q000032:analysis*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D010879:Piperazines; C015568:urapidil; D000432:Methanol