title: Transient abdominal granulomas in children.
abstract: Space-occupying liver lesions in febrile patients are usually caused by tumor or infection and other causes are seldom encountered. In five patients age 20 months to 12 years who were evaluated for fever of unknown origin, imaging studies revealed hepatic nodules consisting of transient, sterile granulomas for which no cause could be determined. Stellate architecture histologically supported clinical evidence of subacute bacterial infection. Imaging modalities included: 99Tc-sulfur colloid (n = 2) and 67Ga (n = 2) scintigraphy; ultrasound (n = 5); computed tomography (n = 4); and magnetic resonance imaging (n = 2). Peripheral low density, as revealed by computed tomography in one and hyperintense halos on magnetic resonance imaging of another patient are both considered predictive for neoplastic disease but were associated with granulomas. The differential diagnosis of macroscopic liver lesions seen on imaging studies in febrile children should include the possibility of transient, idiopathic granulomas.
authors.affiliation: Department of Radiology, University of Texas Southwestern Medical Center, Dallas 75235-9085.
authors.forename: J L
authors.initials: JL
authors.lastname: Fleckenstein
authors.forename: J C
authors.initials: JC
authors.lastname: Argyle
authors.forename: J M
authors.initials: JM
authors.lastname: Cohen
authors.forename: T P
authors.initials: TP
authors.lastname: Votteler
authors.forename: J D
authors.initials: JD
authors.lastname: Nelson
mesh_terms: D002648:Child; D002675:Child, Preschool; D003952:Diagnostic Imaging; D005260:Female; D006099:Granuloma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D011859:Radiography