title: Influence of muscle activity on the elastance of the upper airway of rabbits.
abstract: This study sought to assess the effect of variations in upper airway muscle activity on upper airway pressure-volume properties. Upper airway elastance, closing pressure, and reserve volume were measured in the isolated upper airways of anesthetized rabbits under control conditions and after administration of gallamine (2 mg/kg iv) or after 10 min of spontaneous respiration of 7% CO2 in O2. Administration of gallamine to seven animals was associated with a fall in reserve volume from 0.94 +/- 0.24 to 0.69 +/- 0.17 (95% confidence interval) ml (P less than 0.01) and of closing pressure from -7.53 +/- 0.23 to -5.75 +/- 1.05 cmH2O (P less than 0.01), but airway elastance did not change significantly. Hypercapnia in seven animals was associated with a rise in elastance from 7.06 +/- 0.91 to 7.67 +/- 0.86 cmH2O/ml (P less than 0.001) and in reserve volume from 0.68 +/- 0.06 to 0.86 +/- 0.13 ml (P less than 0.05). Closing pressure also changed from -5.88 +/- 0.94 to -7.92 +/- 1.85 cmH2O. This change was correlated with the change in reserve volume but not with the change in elastance. In three animals exposed to hypercapnia, return to room air breathing was associated with return of elastance, reserve volume, and closing pressure to control levels. It is concluded that muscle activity in the upper airway affects both the size and elastance of the airway, but the dominant mechanism by which upper airway muscles increase the resistance of the upper airway to collapse is by increasing airway volume.
authors.affiliation: Faculty of Medicine, University of Newcastle, New South Wales, Australia.
authors.forename: L G
authors.initials: LG
authors.lastname: Olson
authors.forename: L G
authors.initials: LG
authors.lastname: Ulmer
authors.forename: N A
authors.initials: NA
authors.lastname: Saunders
mesh_terms: D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D004548:Elasticity; D005703:Gallamine Triethiodide / Q000494:pharmacology; D006935:Hypercapnia / Q000503:physiopathology; D008176:Lung Volume Measurements; D009119:Muscle Contraction / Q000187:drug effects; D011312:Pressure; D011817:Rabbits; D012132:Respiratory Muscles / Q000187:drug effects / Q000502:physiology*; D012133:Respiratory Paralysis / Q000503:physiopathology
chemical_list: D005703:Gallamine Triethiodide