[The use of markers for determination of the activity of microsomal enzymes connected with cytochrome p-450].
The mixed-function oxidases, among them cytochrome P-450, are participating in the metabolism of many xenobiotics. Using marker drugs it is possible to assess the induction or inhibition of these oxidases. The paper described the usefulness of use of certain drugs metabolised by this system in various liver diseases. Data from the literature are presented concerning the use of marker drugs labelled with C14 and determination of the effectiveness of the mixed-function oxidases by measurement of 14CO2 activity in exhaled air.
Krajewska
B
B
Lutz
W
W
D001944:Breath Tests; D002250:Carbon Radioisotopes; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy*; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*
D002250:Carbon Radioisotopes; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases
Zastosowanie zwiazków markerowych dla oznaczania aktywności enzymów mikrosomalnych zwiazanych z cytochromem P-450.