title: [Current views on the role of disorders of hormonal regulation in the development of altered sensitivity and reactivity of the bronchi].
abstract: Altered bronchial sensitivity and reactivity are the basis of different variations of bronchospasm. In addition to exogenous agents, endogenous regulation factors such as adrenal and ovarian hormones are believed to make an important contribution to their development. Asthmatics showed the lowest sensitivity and the highest hyperreactivity to acetylcholine as compared to patients with preasthmatic conditions or chronic bronchitis and healthy consanguins of asthmatic patients. Disturbances of glucocorticoid homeostasis, related to various (adrenal, extra-adrenal (transcortin) and cellular) mechanisms of corticosteroid insufficiency, occurred in the majority of asthmatics and asthmatic bronchitis patients. Identification of various mechanisms of glucocorticoid insufficiency opens up actual approaches to increasing the efficiency of an individual therapy.
authors.forename: G B
authors.initials: GB
authors.lastname: Fedoseev
authors.forename: V I
authors.initials: VI
authors.lastname: Trofimov
authors.forename: T M
authors.initials: TM
authors.lastname: Sinitsina
authors.forename: N L
authors.initials: NL
authors.lastname: Shaporova
authors.forename: D P
authors.initials: DP
authors.lastname: Lebedeva
mesh_terms: D001249:Asthma / Q000209:etiology*; D001980:Bronchi / Q000503:physiopathology*; D001986:Bronchial Spasm / Q000209:etiology*; D006706:Homeostasis; D006801:Humans; D006854:Hydrocortisone / Q000172:deficiency*; D011965:Receptors, Glucocorticoid / Q000502:physiology*
chemical_list: D011965:Receptors, Glucocorticoid; D006854:Hydrocortisone
vernacular_title: Sovremennye predstavleniia o roli narusheniĭ gormonal'noĭ reguliatsii v razvitii izmenennykh chuvstvitel'nosti i reaktivnosti bronkhov.