A genetic linkage study of familial breast-ovarian cancer.
Linkage analysis was conducted in 17 families identified by the familial occurrence of breast and ovarian cancer using a series of 17 serologic and biochemical markers. Lod scores suggestive of linkage of breast/ovarian cancer susceptibility to the RH blood group locus on chromosome 1p were obtained. When the presence of fibrocystic disease of the breast in a first-degree relative of an affected family member was added as an indicator of susceptibility, the evidence for linkage increased. No evidence of linkage to GPT or ABO, both previously suggested to be linked to breast cancer susceptibility, was seen in this study.
Ferrell
R E
RE
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261.
Anderson
D E
DE
Chidambaram
A
A
Marino
T R
TR
Badzioch
M
M
D000367:Age Factors; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D010375:Pedigree; D012307:Risk Factors
D005819:Genetic Markers