title: Radial and tibial nerve pathology of two lactating ewes with "kangaroo gait".
abstract: Radial and tibial nerves of two ewes with clinical signs of chronic "kangaroo gait" were examined by qualitative and quantitative techniques and compared to the same nerves of a clinically normal ewe in late lactation. In affected ewes, there was extensive axonal degeneration of myelinated fibres in the radial nerve. Large and small myelinated fibres were affected equally and unmyelinated fibres were normal. Nerve fibre regeneration was present. In contrast, tibial nerve changes in the "kangaroo gait" ewes were minimal. The chronic nature of the radial nerve pathology was consistent with the clinical time course of "kangaroo gait". Regeneration may account for gradual improvement with eventual recovery in most chronically affected ewes. An episode of bilateral severe compression of a proximal radial nerve site is proposed as an explanation for the neuropathy, although the specific mechanism of this trauma is not known.
authors.affiliation: Pathology Department, Central Veterinary Laboratory, New Haw, Weybridge, Surrey, U.K.
authors.forename: D
authors.initials: D
authors.lastname: O'Toole
authors.forename: G A
authors.initials: GA
authors.lastname: Wells
authors.forename: R B
authors.initials: RB
authors.lastname: Green
authors.forename: S A
authors.initials: SA
authors.lastname: Hawkins
mesh_terms: D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D005260:Female; D005684:Gait; D007774:Lactation; D008854:Microscopy, Electron; D009069:Movement Disorders / Q000473:pathology / Q000662:veterinary*; D009410:Nerve Degeneration; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009416:Nerve Regeneration; D011247:Pregnancy; D011826:Radial Nerve / Q000473:pathology*; D012756:Sheep; D012757:Sheep Diseases / Q000473:pathology*; D013979:Tibial Nerve / Q000473:pathology*