title: Metabolic control of food intake.
abstract: A specific biochemical mechanism for the metabolic control of food intake has not been identified. However, a theory based on a signal generated from the oxidation of metabolic fuels and detected in the liver offers a powerful, integrative framework that helps explain a number of phenomena related to feeding behavior. In addition to providing a metabolic basis for the formation of conditioned food flavor preferences, a control of food intake by fuel oxidation provides a mechanism for overeating in the dynamic phase of obesity and hyperphagia produced by high-fat diets.
authors.forename: M I
authors.initials: MI
authors.lastname: Friedman
mesh_terms: D005247:Feeding Behavior / Q000502:physiology*; D006801:Humans; D006963:Hyperphagia / Q000378:metabolism / Q000503:physiopathology*; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology*