The prevention of nitrosomethylurea-induced mammary tumors by d-limonene and orange oil.
The monocyclic monoterpenoid d-limonene and its source, orange oil, were found to prevent rat mammary carcinomas induced by the direct-acting carcinogen nitrosomethylurea. This chemopreventive effect was limited to the promotion/progression stage in this carcinogenesis model.
Maltzman
T H
TH
Department of Human Oncology, University of Wisconsin-Madison 53792.
Hurt
L M
LM
Elson
C E
CE
Tanner
M A
MA
Gould
M N
MN
D000818:Animals; D053138:Cyclohexenes; D005260:Female; D000077222:Limonene; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D008770:Methylnitrosourea / Q000037:antagonists & inhibitors*; D051381:Rats; D011920:Rats, Inbred WF; D013729:Terpenes / Q000494:pharmacology*; D013997:Time Factors
D053138:Cyclohexenes; D013729:Terpenes; D008770:Methylnitrosourea; D000077222:Limonene