Effect of yohimbine on xylazine-induced diuresis in rats.
Intraperitoneal (ip) administration of xylazine (1-6 mg/kg) in male rats significantly increased urine flow over a 2-hr period in a dose-dependent manner, while urine osmolality was significantly decreased. Xylazine at 4.5 and 6 mg/kg significantly increased sodium excretion, whereas the 3 and 6 mg/kg doses of xylazine significantly increased potassium excretion. Yohimbine injected ip at 0.5 or 1 mg/kg 15 min before xylazine (6 mg/kg, ip) significantly decreased urine flow by 44% and 64% respectively. Yohimbine also prevented the increase in sodium and potassium excretion induced by xylazine. The data indicate that yohimbine is of value in controlling the diuretic effect of xylazine in rats.
Mohammad
F K
FK
Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Iraq.
Ahmed
F A
FA
Al-Kassim
N A
NA
D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D008297:Male; D009994:Osmolar Concentration; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000494:pharmacology*; D015016:Yohimbine / Q000494:pharmacology*
D013843:Thiazines; D014991:Xylazine; D015016:Yohimbine; D012964:Sodium; D011188:Potassium