[Gastric acid secretion plays a role in food and water ingestion in mice].
The influence of blockade of the SAG on food and water intake was studied in the mouse. Proglumide (a gastrin receptor antagonist), the combination of proglumide plus cimetidine (inhibitor of the H2 histamine receptors), proglumide plus vagotomy and the simultaneous action of proglumide plus cimetidine plus vagotomy were used in order to get total inhibition of the gastric acid secretion. Statistical analysis shows that food intake experiences a significant increase by the action of proglumide, proglumide plus cimetidine, proglumide plus vagotomy and proglumide plus cimetidine plus vagotomy in comparison to the control group. However, water intake was significantly lower in proglumide plus cimetidine and proglumide plus vagotomy animals with respect to the other groups studied. In addition, proglumide plus cimetidine plus vagotomy increased significantly water intake in relation to the other groups studied. No changes were found in the body weight of the groups studied. We conclude that SAG plays a role in food and water intake in the mouse and both behaviors are interdependent processes.
Bernardo Alvarez
R
R
Menéndez Abraham
E
E
Velasco Plaza
A
A
Marín
B
B
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D004326:Drinking; D004435:Eating; D005744:Gastric Acid / Q000378:metabolism* / Q000502:physiology; D008297:Male; D051379:Mice; D011377:Proglumide / Q000494:pharmacology; D011949:Receptors, Cholecystokinin / Q000187:drug effects / Q000502:physiology; D015167:Vagotomy, Truncal
D011949:Receptors, Cholecystokinin; D002927:Cimetidine; D011377:Proglumide
La secreción ácida gástrica juega un papel en la ingestión de comida y bebida en el ratón.