Effect of anabolic agents on muscle protein metabolism in growing rats treated with glucocorticoids: a short review.
This short review summarizes some of our own results on the effect of glucocorticoids and androgens on the rate of muscle protein turnover as measured by the urinary output of 3-methyl-histidine and 14C-tyrosine constant infusion methods. While high doses of glucocorticoids reduced muscle mass by both increasing protein breakdown and reducing protein synthesis rates, androgens do raise muscle protein by increasing protein synthesis. It is suggested that the anabolic action of androgens could be mediated by their interaction with the glucocorticoid-receptor complex.
Fernández-González
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AL
Departamento de Fisiología, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
Marzo
F
F
Tosar
A
A
Frühbeck
G
G
Santidrián
S
S
D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008762:Methylhistidines / Q000652:urine; D009124:Muscle Proteins / Q000187:drug effects / Q000378:metabolism*; D051381:Rats
D000728:Androgens; D008762:Methylhistidines; D009124:Muscle Proteins; C028118:3-methylhistidine; D003345:Corticosterone