Microencapsulation of phenylpropanolamine to achieve sustained release.
Phenylpropanolamine HCl was initially microencapsulated with cellulose acetate butyrate, however, the microcapsules did not show acceptable sustained release. A reduction of the drug particle size prior to microencapsulation resulted in a reduction in drug release rate from the microcapsules. The desired drug release profile was attained only when the drug powder was replaced with a drug-resin complex in the microencapsulation process. The pH of the dissolution media had an effect on the drug release profile.
Prapaitrakul
W
W
College of Pharmacy, University of Cincinnati, OH 45267.
Whitworth
C W
CW
D003692:Delayed-Action Preparations; D004339:Drug Compounding; D006863:Hydrogen-Ion Concentration; D010665:Phenylpropanolamine / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D010665:Phenylpropanolamine