Evaluation of the carcinogenicity of different preparations of areca nut in mice.
Areca nut has been used as a masticatory since antiquity and it is estimated that more than 10% of the world population chews it in a variety of forms. We have evaluated the carcinogenicity of different preparations of areca nut: ripe-unprocessed-sundried nut (R-UP-SD), ripe-processed-sundried nut (R-P-SD), unripe-processed-sundried nut (UR-P-SD), ripe-unprocessed-sundried-water-soaked nut (R-UP-SD-WS) and ripe-unprocessed-undried-water-soaked nut (R-UP-UD-WS) in mice following diet-feeding or oral feeding for 12 months. Only unprocessed areca nuts (R-UP-SD, R-UP-SD-WS and R-UP-UD-WS), at high doses, displayed a very weak carcinogenicity.
Rao
A R
AR
Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Das
P
P
D000284:Administration, Oral; D000818:Animals; D001114:Areca; D002273:Carcinogens / Q000633:toxicity*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000453:epidemiology / Q000209:etiology; D008297:Male; D051379:Mice; D009754:Nuts; D009824:Ointments; D010946:Plants, Medicinal; D011230:Precancerous Conditions / Q000453:epidemiology / Q000209:etiology; D013997:Time Factors
D002273:Carcinogens; D009824:Ointments