[Lowering of bactericidal activity of mouse peritoneal macrophages under combined use of staphylococcal enterotoxin type A and endotoxin].
The present study investigated the effect of staphylococcal enterotoxin type A (SEA) and endotoxin Serratia marcescens (LPS) on the phagocytosis and killing of Staphylococcus aureus by mouse peritoneal macrophages. Two hours after enterotoxin intraperitoneal injection phagocytic and bactericidal activity were depressed. 24 hours later there was increased functional activity of macrophages by SEA and LPS, apart. But when two toxins were administered together (LPS four hours later enterotoxin) marked inhibition of bacterial killing was observed. When peritoneal macrophages were treated in vitro for 24 hours with the same toxins they were also markedly suppressed in bactericidal activity.
Riabichenko
E V
EV
Ezepchuk
Iu V
IuV
D000818:Animals; D004731:Endotoxins / Q000008:administration & dosage*; D004768:Enterotoxins / Q000008:administration & dosage*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D010529:Peritoneal Cavity; D010587:Phagocytosis; D012706:Serratia marcescens; D013211:Staphylococcus aureus
D004731:Endotoxins; D004768:Enterotoxins
Snizhenie bakterial'noĭ aktivnosti peritoneal'nykh makrofagov mysheĭ v usloviiakh sochetannogo primeneniia stafilokokkovogo énterotoksina tipa A i éndotoksina.