Antisperm antibodies are more prevalent in men with low sperm motility.
Fifty-six men with low sperm motility (less than or equal to 40% of sperm with forward progression) who attended our infertility clinic were tested for antisperm antibodies (IgG and IgA) using the indirect immunobead test. Nineteen (34%) of these men were found to be positive (greater than 10% binding). This was significantly higher (P less than 0.01) than the incidence (5%) of antibodies in men who attended our infertility clinic with high sperm motility (greater than 40% of sperm with forward progression). It is concluded that significantly more men with low sperm motility have antisperm antibodies. The functional significance of these antibodies warrants further investigation.
Barratt
C L
CL
Harris Birthright Research Centre, Reproductive Medicine, Jessop Hospital for Women, Sheffield, U.K.
Havelock
L M
LM
Harrison
P E
PE
Cooke
I D
ID
D001323:Autoantibodies / Q000032:analysis*; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000276:immunology; D008297:Male; D012661:Semen / Q000276:immunology; D013081:Sperm Motility; D013094:Spermatozoa / Q000276:immunology*
D001323:Autoantibodies