title: Effects of aflatoxin, deoxynivalenol, and their combinations in the diets of growing pigs.
abstract: In 2 studies, the effects of dietary aflatoxin (AF) and deoxynivalenol (DON) were evaluated in growing crossbred barrows. The first study consisted of 4 treatments of 5 barrows each (6 weeks old) at dosages of 0 mg of DON and AF (control), 2.5 mg of DON/kg of feed, 0.75 mg of AF/kg of feed, and 2.5 mg of DON + 0.75 mg of AF/kg of feed. Pigs were fed their respective diets for 21 days. Treatment with DON caused decreases in weight gains, but no other treatment-related differences could be attributed to diets. In a second study, the experimental design consisted of 4 treatments of 5 barrows each (6 weeks old) at dosages of 0 mg of DON and AF (control), 3 mg of DON/kg of feed, 3 mg of AF/kg of feed, and 3 mg of DON + 3 mg of AF/kg of feed fed ad libitum for 28 days. The pigs were observed twice daily for clinical signs, hematologic and serum biochemical measurements were made weekly, and body weights and feed consumption were determined weekly. Body weight gains were significantly depressed by the AF and the AF + DON treatments for days 7, 14, 21, and 28. Body weights and body weight gains were only slightly reduced in the DON treatment. Changes in serum enzymatic activities of alkaline phosphatase, aspartate transaminase, creatine kinase, and gamma-glutamyl transferase were noticed in pigs given treatments with AF alone and those given AF + DON.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: USDA, Agricultural Research Service, Veterinary Toxicology and Entomology Research Laboratory, College Station, TX 77841.
authors.forename: R B
authors.initials: RB
authors.lastname: Harvey
authors.forename: L F
authors.initials: LF
authors.lastname: Kubena
authors.forename: W E
authors.initials: WE
authors.lastname: Huff
authors.forename: D E
authors.initials: DE
authors.lastname: Corrier
authors.forename: D E
authors.initials: DE
authors.lastname: Clark
authors.forename: T D
authors.initials: TD
authors.lastname: Phillips
mesh_terms: D000348:Aflatoxins / Q000633:toxicity*; D000821:Animal Feed; D000818:Animals; D001772:Blood Cell Count; D001774:Blood Chemical Analysis / Q000662:veterinary; D004798:Enzymes / Q000097:blood; D008297:Male; D012717:Sesquiterpenes / Q000633:toxicity*; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D014255:Trichothecenes / Q000633:toxicity*; D015430:Weight Gain
chemical_list: D000348:Aflatoxins; D004798:Enzymes; D012717:Sesquiterpenes; D014255:Trichothecenes; C007262:deoxynivalenol