title: [Modification of blood coagulation by the anti-arrhythmia drug prajmalium bitartrate in vivo].
abstract: We studied the effects of prajmaliumbitartrate (PBT, Neo-Gilurytmal, Giulini Pharma, Hannover, FRG), an antiarrhythmic drug on some parameters of blood coagulation in patients. PBT, 20 mg given three times a day, significantly prolonged template bleeding time and ex vivo thrombus formation time in a modified Chandler's loop. Ex vivo platelet aggregation using different agonists and tests of the plasmatic coagulation system remained unchanged.
authors.affiliation: Medizinische Kliniken III, Ludwig-Maximilians-Universität, München.
authors.forename: H
authors.initials: H
authors.lastname: Riess
authors.forename: F
authors.initials: F
authors.lastname: Bauer
authors.forename: E
authors.initials: E
authors.lastname: Hoffmann
authors.forename: G
authors.initials: G
authors.lastname: Steinbeck
authors.forename: E
authors.initials: E
authors.lastname: Hiller
mesh_terms: D000404:Ajmaline / Q000031:analogs & derivatives*; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000188:drug therapy*; D001760:Bleeding Time; D001780:Blood Coagulation Tests; D006801:Humans; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010976:Platelet Count / Q000187:drug effects; D010979:Platelet Function Tests; D011219:Prajmaline / Q000627:therapeutic use*
chemical_list: D000404:Ajmaline; D011219:Prajmaline
vernacular_title: Beeinflussung der Blutgerinnung durch das Antiarrhythmikum Prajmaliumbitartrat in vivo.