Induction of cloacal and dermal skin glands of tiger salamander larvae, (Ambystoma tigrinum): effects of testosterone and prolactin.
Treatment of male and female tiger salamander larvae with testosterone (0.3 micrograms/g body weight/day) induced precocious formation of ventral cloacal glands and stimulated proliferation and differentiation of mucous and granular (serous) glands in the ventral dermis of the skin. Lower doses of testosterone produced no visible glandular effects but did cause hyperemia and edema in the cloacal region. Prolactin (0.5 micrograms/g body weight/day) enhanced the action of testosterone on the cloacal glands, increasing both the amount of gland induced and the degree of glandular secretion. There was no apparent effect of prolactin alone on cloacal glands or any effect of prolactin with or without testosterone on the dermal glands. The possible homology of the amphibian ventral cloacal gland to the mammalian prostate gland is discussed.
Norris
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Department of Environmental, University of Colorado, Boulder 80309-0334.
Austin
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Hijazi
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D000557:Ambystoma / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002988:Cloaca; D004702:Endocrine Glands / Q000166:cytology*; D005260:Female; D007814:Larva / Q000166:cytology / Q000502:physiology; D008297:Male; D011388:Prolactin / Q000494:pharmacology*; D012867:Skin; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D011388:Prolactin