[3H]-acetylcholine release from rat atria in chronic chagasic cardiopathy.
Isolated superfused rat atria release [3H]-acetylcholine when depolarized with 57 mM potassium. The depolarization-induced [3H]-acetylcholine overflow was significantly reduced in atria from chronically T. cruzi-infected rats with electrocardiographically characterized cardiopathy. This fact suggests the occurrence of functional alterations of cardiac parasympathetic control in these animals, probably related to cardiac ganglion cell destruction.
Figuerêdo-Silva
J
J
Departamento de Patologia, Universidade Federal de Pernambuco, Recife, PE, Brasil.
Coutinho-Netto
J
J
Bestetti
R B
RB
Oliveira
J S
JS
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002598:Chagas Cardiomyopathy / Q000503:physiopathology*; D005726:Ganglia, Parasympathetic / Q000503:physiopathology; D006325:Heart Atria; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D014316:Tritium
D014316:Tritium; D000109:Acetylcholine