title: Stimulation of hematopoiesis and antibacterial resistance by interleukin-1.
abstract: The beneficial effects of IL-1 and other cytokines on hematopoiesis and on resistance to infection are profound. IL-1 stimulates proliferation of bone marrow cells in normal mice and potentiates the recovery of peripheral blood neutrophils in mice with drug-induced neutropenia. Prophylactic cytokine administration provides an elevated level of natural resistance to infections which is correlated with increased numbers of phagocytic leukocytes. These studies suggest that IL-1 has potential clinical application as a therapy to limit bone marrow dysfunction and immunosuppression and to augment hematopoiesis and natural immunity. Further research will continue to elucidate the mechanisms whereby interleukins and colony-stimulating factors act, and interact, to promote restoration of leukocyte production and to enhance host resistance.
authors.affiliation: Roche Research Center, Hoffmann-LaRoche Inc., Nutley, NJ 07110.
authors.forename: K W
authors.initials: KW
authors.lastname: McIntyre
authors.forename: J
authors.initials: J
authors.lastname: Unowsky
authors.forename: W
authors.initials: W
authors.lastname: DeLorenzo
authors.forename: N S
authors.initials: NS
authors.lastname: Tare
authors.forename: J M
authors.initials: JM
authors.lastname: Plocinski
authors.forename: W R
authors.initials: WR
authors.lastname: Benjamin
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D007375:Interleukin-1 / Q000494:pharmacology*; D051379:Mice; D013268:Stimulation, Chemical
chemical_list: D007375:Interleukin-1