[The origin of lipofuscin granules in a hybridoma cell culture].
The ultrastructure of lipofuscin granules (LG) in hybridoma cells is described. Based on the electron microscopic evidence and literature data the possibility of generation of LG from cell endoplasmic reticulum (ER) is discussed. It is proposed that the production of LG is connected with disturbances in glycosylation of proteins and lipids on the ER membranes.
Tatariunas
A B
AB
D000818:Animals; D002478:Cells, Cultured; D003594:Cytoplasmic Granules / Q000378:metabolism* / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000378:metabolism / Q000648:ultrastructure; D006031:Glycosylation; D006825:Hybridomas / Q000378:metabolism* / Q000648:ultrastructure; D008062:Lipofuscin / Q000378:metabolism*; D051379:Mice; D008854:Microscopy, Electron; D010860:Pigments, Biological / Q000378:metabolism*
D008062:Lipofuscin; D010860:Pigments, Biological
Proiskhozhdenie lipofustsinovykh granul v kul'ture gibridomnykh kletok.