Radioresistance induced by oncogenic transformation.
Rat embryo cells at various stages of oncogenic transformation are obtained by a combination of X irradiation and transfection with the ras and the myc oncogenes. Transfection with either the ras or the myc oncogenes can lead to increased radioresistance, relative to the parental cells. X-ray-transformed clones of the transfected cells do not show additional alteration in radioresponse. Incorporation of the two oncogenes appears to lead to a higher degree of radioresistance.
Ling
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CC
Physics Division, University of California, San Francisco 94143.
Endlich
B
B
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D011905:Genes, ras; D066298:In Vitro Techniques; D009857:Oncogenes; D011836:Radiation Tolerance / Q000235:genetics*; D051381:Rats; D014162:Transfection