A feeding regime for the study of the interaction of ethanol and aging.
A suitable model for the study of the interaction of the aging process and prolonged treatment with ethanol is described. Animals were given 15% ethanol in the drinking water for up to 25 months. There was little disruption in the growth of the animals. Ethanol treatment resulted in a number of neurological and morphological changes some of which persisted throughout the treatment period. Both young and old animals displayed metabolic tolerance by the criteria of resistance to ethanol-induced hypothermia and increased metabolism of [14C]ethanol. The regime used has proved useful in the study of the interaction of ethanol and aging in the rat.
Pietrzak
E R
ER
Department of Biochemistry, University of Queensland, St Lucia, Australia.
Wilce
P A
PA
Ward
L C
LC
Shanley
B C
BC
D000375:Aging / Q000502:physiology*; D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002149:Energy Intake / Q000187:drug effects; D000431:Ethanol / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D008297:Male; D008954:Models, Biological; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol