title: [Effect of the antitumor preparations prospidin and spirobromin on the function of the liver lysosomal apparatus in mice].
abstract: Antitumour drugs prospidine and spirobromine were shown to suppress the activity of the mouse liver lysosome enzymes in vivo and in experiments in vitro. The revealed effect was underlied by a decrease of lysosomal membrane permeability for the corresponding substrates and enzymes rather than a reduction of the catalytic activity of acid hydrolases.
authors.forename: T K
authors.initials: TK
authors.lastname: Kliment'eva
authors.forename: B Iu
authors.initials: BIu
authors.lastname: Sal'nik
authors.forename: G M
authors.initials: GM
authors.lastname: Chamina
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D003902:Detergents / Q000493:pharmacokinetics / Q000494:pharmacology; D006867:Hydrolases / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D017830:Octoxynol; D010879:Piperazines / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000493:pharmacokinetics / Q000494:pharmacology; D011447:Prospidium / Q000493:pharmacokinetics / Q000494:pharmacology*; D013141:Spiro Compounds / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D003902:Detergents; D010879:Piperazines; D013141:Spiro Compounds; D011092:Polyethylene Glycols; D011447:Prospidium; C054863:spirobromin; D017830:Octoxynol; D006867:Hydrolases
vernacular_title: Vliianie protivoopukholevykh preparatov prospidina i spirobromina na sostoianie lizosomal'nogo apparata pecheni mysheĭ.