title: Clinical signs and biochemical changes in calves caused by injection of ivermectin.
abstract: Eight-month-old Jersey bull calves given ivermectin intravenously or subcutaneously showed signs of depression, ataxia, difficulty in breathing, tachycardia, salivation, diarrhoea, miosis, and an increase in pseudocholinesterase activity. The clinical signs were severe in calves given the drug intravenously. The findings suggest that the cholinergic nervous system may be involved in some of the adverse effects of ivermectin observed in calves.
authors.affiliation: Department of Paraclinical Veterinary Studies, University of Zimbabwe, Mount Pleasant, Harare.
authors.forename: C D
authors.initials: CD
authors.lastname: Basudde
mesh_terms: D000818:Animals; D001259:Ataxia / Q000139:chemically induced / Q000662:veterinary; D002091:Butyrylcholinesterase / Q000097:blood; D002417:Cattle / Q000502:physiology*; D002418:Cattle Diseases / Q000139:chemically induced* / Q000503:physiopathology; D003967:Diarrhea / Q000139:chemically induced / Q000662:veterinary; D004573:Electrolytes / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D007501:Iron / Q000097:blood; D007559:Ivermectin / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D012119:Respiration / Q000187:drug effects; D012472:Salivation / Q000187:drug effects
chemical_list: D004573:Electrolytes; D007559:Ivermectin; D007501:Iron; D002091:Butyrylcholinesterase