Fulminant transfusion-associated graft-versus-host disease in a premature infant.
A fatal case of transfusion-associated graft-versus-host disease developed in a premature infant after receiving several blood products, including nonirradiated white blood cells. Transfusion-associated graft-versus-host disease can be prevented. Irradiation of blood products is the least controversial and most effective method. Treatment was unsuccessful in most reported cases of transfusion-associated graft-versus-host disease. Therefore irradiation of blood products before transfusing to patients susceptible to transfusion-associated graft-versus-host disease is strongly recommended.
Berger
R S
RS
Department of Dermatology, Wilford Hall United States Air Force Medical Center, Lackland Air Force Base, Texas.
Dixon
S L
SL
D001769:Blood / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004890:Erythema / Q000209:etiology; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications / Q000209:etiology* / Q000401:mortality / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000209:etiology* / Q000473:pathology; D012867:Skin / Q000473:pathology; D065227:Transfusion Reaction