title: Hemodynamic effects of blood volume restitution following a hemorrhage in rats with portal hypertension due to cirrhosis of the liver: influence of the extent of portal-systemic shunting.
abstract: The present study investigated whether, in rats with portal hypertension due to cirrhosis of the liver induced by carbon tetrachloride, blood volume restitution following a hemorrhage produces an increase of portal pressure beyond control values, as observed in rats with prehepatic portal hypertension. Since carbon tetrachloride-induced cirrhosis caused mild portal-systemic shunting, in some of the cirrhotic rats (12 of 29 rats) portal-systemic shunting was enhanced by a transient (4 days) partial constriction of the portal vein, which was removed 1 week prior to the study. After baseline measurements of portal pressure and arterial pressure, 15 ml per kg of blood were withdrawn at a rate of 0.3 ml per min and reinfused 15 min later. After blood reinfusion, portal pressure and arterial pressure were measured again, and cardiac output, regional blood flows and portal-systemic shunting were determined using radioactive microspheres. Portal-systemic shunting was 78 +/- 11% of total blood flow in the cirrhotic rats that had temporary portal vein constriction, but only 5 +/- 2% (p less than 0.001) in those that did not. Blood volume restitution in low-portal-systemic shunting rats did not produce any significant modification in splanchnic or systemic hemodynamics. However, in rats with high portal-systemic shunting, blood volume restitution produced a significant increase in portal pressure (from 9.9 +/- 0.9 to 13.5 +/- 0.9 mmHg, p less than 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Hepatic Hemodynamics Laboratory, Hospital Clínic i Provincial, University of Barcelona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Kravetz
authors.forename: J
authors.initials: J
authors.lastname: Bosch
authors.forename: M
authors.initials: M
authors.lastname: Arderiu
authors.forename: M
authors.initials: M
authors.lastname: Pilar Pizcueta
authors.forename: J
authors.initials: J
authors.lastname: Rodés
mesh_terms: D000818:Animals; D001810:Blood Volume; D002251:Carbon Tetrachloride; D003097:Collateral Circulation; D006439:Hemodynamics; D006470:Hemorrhage / Q000503:physiopathology* / Q000628:therapy; D006975:Hypertension, Portal / Q000150:complications / Q000503:physiopathology*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002251:Carbon Tetrachloride