Variations in serum alkaline DNase activity in rats during growth and treatment of tumors sensitive or resistant to therapy.
Serum alkaline DNase activity (SADA) was investigated in rats receiving s.c. transplants of tumor cells sensitive or resistant to chemotherapy. Serum samples from each animal were collected before transplantation, during the development of tumors and after therapy. Within a few days after transplantation of both tumor lines (sensitive or resistant), SADA levels decreased progressively to 52% of the normal pre-transplantation level (p less than 0.01). This decrease in SADA preceded by 4 to 5 days the appearance of any palpable tumor mass. In all untreated animals as well as in treated rats bearing resistant tumors, SADA remained at a low level until death. In rats bearing tumors sensitive to therapy a progressive increase in SADA was observed after treatment, paralleling tumor regression. When tumor regression was complete, SADA resumed the levels of activity measured prior to transplantation.
Economidou-Karaoglou
A
A
Unité de Biochimie Toxicologique et Cancérologique, UCL 7369, Faculté de Médecine, Université de Louvain, Brussels, Belgium.
Brasseur
F
F
Lans
M
M
Taper
H S
HS
Roberfroid
M B
MB
D000230:Adenocarcinoma / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology*; D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood; D003520:Cyclophosphamide / Q000627:therapeutic use*; D003851:Deoxyribonucleases / Q000097:blood*; D004351:Drug Resistance; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D014747:Vinblastine / Q000627:therapeutic use*
D014408:Biomarkers, Tumor; D014747:Vinblastine; D003520:Cyclophosphamide; D003851:Deoxyribonucleases