title: [Which treatment for primary tuberculosis?].
abstract: Primary tuberculosis should be treated in all cases. In adults, the total treatment course for pulmonary tuberculosis can be shortened to 6 months. If the disease is not symptomatic, the rifampicin-isoniazid combination (10 mg/kg/day each) appears to be preferable to single drug therapy. In patients with symptomatic disease, pyrazinamide (30 mg/kg/day) should be added during the first 6-8 weeks and in some cases, corticosteroid therapy is also required. The drugs are usually well tolerated, but hepatic function should be monitored.
authors.affiliation: Clinique médicale infantile, Centre Hospitalier Lyon-Sud, France.
authors.forename: S
authors.initials: S
authors.lastname: Gallet
authors.forename: G
authors.initials: G
authors.lastname: Bellon
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004977:Ethambutol / Q000627:therapeutic use; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D011718:Pyrazinamide / Q000627:therapeutic use; D012293:Rifampin / Q000627:therapeutic use*; D013307:Streptomycin / Q000627:therapeutic use*; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy*
chemical_list: D011718:Pyrazinamide; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin
vernacular_title: Quel traitement pour la tuberculose initiale?