title: What's new in the localization of sex steroids in the human ovary and its tumors?
abstract: It is important to understand the distribution of steroidogenesis in steroid producing tissues in order to obtain a better understanding of steroid metabolism. Recent advances in purification and subsequent generation of antibodies against cytochromes P-450 specific for steroid hormone biosynthesis have made it possible to localize the sites of steroidogenesis immunohistochemically. This review provides the localization of sex-steroid hormone biosynthesis in normal and pathological human ovaries including sex-cord stromal tumors, hyperthecosis and Brenner tumor, as determined by the tissue distribution of immunoreactivity of individual enzymes specific for different stages of the biosynthetic process.
authors.affiliation: Department of Pathology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sasano
authors.forename: N
authors.initials: N
authors.lastname: Sasano
mesh_terms: D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D010053:Ovary / Q000166:cytology / Q000378:metabolism*; D013256:Steroids / Q000378:metabolism*
chemical_list: D013256:Steroids