Two types of GABA-containing axon terminals in cerebellar glomeruli of cat: an immunogold-EM study.
Immunogold demonstration of GABA was used in ultrathin sections of cerebellar cortex of cat to identify GABA(+) profiles in cerebellar glomeruli. In addition to small, GABA-containing axonal varicosities found at the periphery of all glomeruli, a few complex glomeruli were found to contain a second type of GABA(+) terminal, with a mossy ending appearance. GABA(+) type "I" axon terminals, which were identified as the axonal arborization of local Golgi cells, contained ovoid, small synaptic vesicles. GABA(+) type "II" terminals, however, exhibited large, spheroid synaptic vesicles. Experimental evidence is provided that type "II" GABA(+) mossy like terminals are the endings of nucleocortical fibers.
Hámori
J
J
Ist Department of Anatomy, Semmelweis University Medical School, Budapest, Hungary.
Takács
J
J
D000818:Animals; D002415:Cats; D002531:Cerebellum / Q000166:cytology* / Q000378:metabolism; D006046:Gold; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009411:Nerve Endings / Q000378:metabolism* / Q000648:ultrastructure; D013572:Synaptic Vesicles / Q000648:ultrastructure; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D006046:Gold