A specific diagnostic antigen of Echinococcus granulosus with an apparent molecular weight of 8 kDA.
An echinococcus antigen with an apparent molecular weight of 8 kDa was identified as diagnostically important. An immunoblot assay using this antigen was 91% sensitive for surgically confirmed Echinococcus granulosus hydatid disease of the liver. Specificity was 100% for echinococcosis. Marked cross-reactivity was observed with serum specimens from patients with E. multilocularis and E. vogeli infections. The 8 kDa component was not related to the widely recognized echinococcus antigen 5.
Maddison
S E
SE
Division of Parasitic Diseases, Centers for Disease Control, Atlanta, Georgia.
Slemenda
S B
SB
Schantz
P M
PM
Fried
J A
JA
Wilson
M
M
Tsang
V C
VC
D000818:Animals; D000911:Antibodies, Monoclonal; D000947:Antigens, Helminth / Q000302:isolation & purification*; D002162:Camelus; D002417:Cattle; D003670:Deer; D004443:Echinococcosis / Q000175:diagnosis* / Q000378:metabolism; D004446:Echinococcus / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D015151:Immunoblotting; D008970:Molecular Weight; D012698:Serologic Tests / Q000379:methods; D012756:Sheep
D000911:Antibodies, Monoclonal; D000947:Antigens, Helminth