Eimeria vermiformis and E. mitis: inhibition of development in vivo by cyclosporin A.
Treatment of the host (Mus musculus, Gallus domesticus) with cyclosporin A during infection with Eimeria vermiformis or E. mitis resulted in a reduction in the numbers of oocysts passed in the feces and/or a delay in patency. The general immunosuppressive effects of the treatment were confirmed in chickens by monitoring their antibody responses to human erythrocytes and lymphoproliferative responses to phytohemagglutinin. Nevertheless, mice and chickens treated with cyclosporin A during a primary infection with E. vermiformis or E. mitis, respectively, were immune to subsequent challenge with these organisms. Thus, cyclosporin A did not interfere with priming. The antiparasite effect of the drug did not allow an evaluation of its effect on established immunity to the coccidia when it was administered at the time of challenge. In an exceptional treated chicken, however, delayed patency of the challenge infection was followed by the production of a number of oocysts similar to that found in unprimed animals. This suggests that the mechanisms of immunity to challenge may be susceptible to disruption by cyclosporin A.
Rose
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ME
Houghton Laboratory, Institute for Animal Health, Huntingdon, England, United Kingdom.
Hesketh
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D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy / Q000276:immunology* / Q000469:parasitology; D003524:Cyclosporins / Q000494:pharmacology* / Q000627:therapeutic use; D004539:Eimeria / Q000187:drug effects* / Q000254:growth & development; D005260:Female; D006386:Hemagglutination Tests; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C
D003524:Cyclosporins