title: Clinical, psychophysiological, and neurological characteristics of volunteers with impaired smooth pursuit eye movements.
abstract: Two hundred eighty-five volunteers from a community college were screened on campus for accuracy of their smooth pursuit eye movements (SPEM) by electrooculograph (EOG). Those volunteers with the least and the most accurate SPEM were recalled to the laboratory for a comprehensive evaluation of clinical and demographic characteristics, family history, neurological status, and psychophysiological and biological measures, including SPEM [repeat EOG test and infrared (IR) test], an electroencephalogram, auditory and visual evoked potentials, reaction time (RT), the continuous performance task (CPT), platelet monoamine oxidase (MAO), plasma amine oxidase, and dopamine-beta-hydroxylase (DBH). Low-accuracy SPEM was associated with social isolation, inadequate rapport, eccentricity, and a variety of related schizotypal or schizophrenia-like characteristics, but not with generalized psychopathology or other demographic/medical/clinical history variables. Low-accuracy SPEM also was associated with neurological and psychophysiological abnormalities frequently observed in schizophrenic patients. These results suggest that impaired SPEM may reflect an underlying central nervous system dysfunction that is specifically associated with clinical and biological characteristics related to schizophrenia, even in the absence of overt schizophrenia.
authors.affiliation: Laboratory of Clinical Science, National Institutes of Mental Health, Bethesda, MD.
authors.forename: L J
authors.initials: LJ
authors.lastname: Siever
authors.forename: R D
authors.initials: RD
authors.lastname: Coursey
authors.forename: I S
authors.initials: IS
authors.lastname: Alterman
authors.forename: T
authors.initials: T
authors.lastname: Zahn
authors.forename: L
authors.initials: L
authors.lastname: Brody
authors.forename: P
authors.initials: P
authors.lastname: Bernad
authors.forename: M
authors.initials: M
authors.lastname: Buchsbaum
authors.forename: C R
authors.initials: CR
authors.lastname: Lake
authors.forename: D L
authors.initials: DL
authors.lastname: Murphy
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology; D001883:Borderline Personality Disorder / Q000503:physiopathology; D001933:Brain Stem / Q000503:physiopathology; D005072:Evoked Potentials, Auditory; D005074:Evoked Potentials, Visual; D005133:Eye Movements; D006801:Humans; D019965:Neurocognitive Disorders / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales; D011698:Pursuit, Smooth; D011930:Reaction Time / Q000502:physiology; D012569:Schizotypal Personality Disorder / Q000503:physiopathology; D012934:Social Isolation