Enhanced acetylcholine release from denervated atria: intrinsic neural supersensitivity.
Atrial tissue from denervated dog hearts was incubated with [3H]choline. When compared with controls, nicotine released more acetylcholine (ACh) from denervated atria at 10(-5) and 2 x 10(-5) M, but not at 5 x 10(-5) M. In parallel contractility studies using tissue from these same atria, the negative inotropic response to nicotine was enhanced at 5 x 10(-6) and 10(-5) M, but not at 2 x 10(-5) or 5 x 10(-5) M nicotine. These results indicate that denervation (i.e. decentralization) supersensitivity of the intrinsic cardiac nerves of canine hearts is characterized by enhanced release of ACh.
Smith
D C
DC
Department of Physiology, School of Medicine, University of New Mexico, Albuquerque 87131.
Priola
D V
DV
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D004285:Dogs; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D009121:Muscle Denervation; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D009538:Nicotine / Q000494:pharmacology
D009538:Nicotine; D000109:Acetylcholine