[Effect of propiverine hydrochloride on the function of the bladder in dogs].
Propiverine hydrochloride (P-4) is a new derivative of benzilic acid. The effect of P-4 on the function of the bladder in anesthetized dogs was studied in comparison with flavoxate, which is clinically used for the treatment of pollakiuria. P-4 (4 mg/kg, i.v.) caused a significant increase in maximum vesical volume (Vmax), which was estimated by a cystometrogram. A similar effect was also observed following intravenous administration of verapamil (1 mg/kg), while flavoxate (4 mg/kg, i.v.) caused no significant changes in Vmax. P-4 significantly decreased the frequency of rhythmic bladder contractions at doses higher than 1 mg/kg, i.v., whereas flavoxate first revealed a significant decrease at 4 mg/kg, i.v. Thus the inhibitory effect of P-4 on the micturition movements of the bladder is more potent than that of flavoxate. These findings indicate that P-4 is a useful drug for the treatment of pollakiuria.
Kaneko
S
S
Biol. Res. Lab. Taiho Pharm. Co., Ltd., Tokushima, Japan.
Haruno
A
A
Suzuki
N
N
Kitazato
K
K
Yamazaki
Y
Y
Nagai
M
M
Iriki
M
M
Tsuchiya
K
K
Kosaka
M
M
D000818:Animals; D001561:Benzilates / Q000494:pharmacology* / Q000627:therapeutic use; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005422:Flavoxate / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology* / Q000627:therapeutic use; D011141:Polyuria / Q000188:drug therapy; D001743:Urinary Bladder / Q000187:drug effects*; D014554:Urination / Q000187:drug effects*
D001561:Benzilates; D010276:Parasympatholytics; D005422:Flavoxate; C015586:propiverine