High-performance liquid chromatographic evaluation of PCF 39, a new immunomodulator agent.
An high-performance liquid chromatographic analysis of PCF 39, N2-[5-(hypoxanthin-9-yl)pentyloxycarbonyl]-L-arginine, with ultraviolet detection, has been devised and validated. The main pharmacokinetic results encountered for rats treated intravenously with PCF 39 at a dose of 100 mg/kg are described.
Marzo
A
A
Real srl, Como, Italy.
Monti
N
N
Ripamonti
M
M
Cardace
G
G
Arrigoni Martelli
E
E
D000276:Adjuvants, Immunologic / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D002110:Caffeine / Q000097:blood / Q000652:urine; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D007042:Hypoxanthines / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000276:Adjuvants, Immunologic; D007042:Hypoxanthines; C054420:PCF 39; D002110:Caffeine; D001120:Arginine