title: The biodistribution of [75Se]bis-[beta-(N,N,N-trimethylamino)ethyl]selenide diiodide in adult guinea pigs.
abstract: The biodistribution of [75Se]BISTAES was studied in guinea pigs. A higher concentration of radioactivity was observed in articular cartilage than in other tissues or organs. A minimal amount of radioactivity was found in the blood, muscle and bone. The compound was excreted rapidly in urine. The target to background ratios were encouraging. [75Se]BISTAES has potential as an articular cartilage imaging agent and further studies in osteoarthritic animals are merited.
authors.affiliation: School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana.
authors.forename: W K
authors.initials: WK
authors.lastname: Yu
authors.forename: S M
authors.initials: SM
authors.lastname: Shaw
authors.forename: J M
authors.initials: JM
authors.lastname: Bartlett
authors.forename: D C
authors.initials: DC
authors.lastname: Van Sickle
authors.forename: B H
authors.initials: BH
authors.lastname: Mock
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000000981:diagnostic imaging* / Q000378:metabolism; D006168:Guinea Pigs; D010003:Osteoarthritis / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D012644:Selenium Radioisotopes / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D012644:Selenium Radioisotopes; C055707:bis(N,N,N-trimethylamino)ethylselenide-Se iodide