[Effect of gamma-aminobutyric acid on the development of catatonia-like states in mice].
Catatony-like states including periods of tonic immobility and locomotor paroxysms were induced in mice by a single pinch at the scruff of the neck. GABA-positive drugs (aminooxyacetic acid 20 mg/kg, muscimol 0.5 mg/kg) increased the duration of periods of immobility as compared with control. GABA-negative drugs (thiosemicarbazide 5 mg/kg, bicuculline 3 mg/kg in combination with aminooxyacetic acid) increased only the number and duration of locomotor paroxysms.
Kudriavtseva
N N
NN
Bakshtanovskaia
I V
IV
D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D002389:Catatonia / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009118:Muscimol / Q000494:pharmacology; D012663:Semicarbazides / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000494:pharmacology*
D012663:Semicarbazides; D000625:Aminooxyacetic Acid; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; C005151:thiosemicarbazide; D001640:Bicuculline
Vliianie gamma-aminomaslianoĭ kisloty na razvitie katatonopodobnykh sostoianiĭ u mysheĭ.