Stimulation of G2-arrested rat liver and pancreas cells by fasting.
The present study complements earlier work that revealed a mitogenic effect of fasting on G2-blocked hepatocytes, demonstrating that the release of hepatocytes from the G2 arrest is maximal at 3 h of fasting and that the phenomenon lasts for 12 h. The mitogenic effect of fasting is not restricted to the liver, as similar results were obtained with the pancreas--suggesting a possible action on other organs as well. A simple physiologic stimulus such as fasting can thus be used in further studies on the properties of G2 cell populations and their possible role in the regulation of normal and abnormal growth processes.
Daoust
R
R
Institut du Cancer de Montréal, Hôpital Notre-Dame, Montréal, Canada.
D000818:Animals; D005215:Fasting; D007399:Interphase; D008099:Liver / Q000166:cytology* / Q000502:physiology; D008297:Male; D008940:Mitotic Index; D010179:Pancreas / Q000166:cytology* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains