Studies of the mechanisms of nuclear control over the synthesis of mitochondrial DNA in sea urchin eggs.
We have studied the contribution of nuclear genomic activity and of the cytoskeletal integrity in the negative control operated by the nucleus over the mitochondrial genome. We have found that the nuclear control is exerted even in the presence of nuclei that have undergone heavy irradiation such as to block at least DNA replication and in the absence of intact microtubules. Data are presented which suggest some implication of ion (Ca++) movements in this negative control.
Rinaldi
A M
AM
Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Italy.
Salcher-Cillari
I
I
D000818:Animals; D002467:Cell Nucleus / Q000502:physiology*; D002701:Chloramphenicol / Q000494:pharmacology; D004272:DNA, Mitochondrial / Q000096:biosynthesis*; D003703:Demecolcine / Q000494:pharmacology; D008297:Male; D008870:Microtubules / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism; D008938:Mitosis / Q000187:drug effects; D010063:Ovum / Q000378:metabolism*; D012617:Sea Urchins
D004272:DNA, Mitochondrial; D002701:Chloramphenicol; D003703:Demecolcine