Chorionic villus sampling--short-term versus long-term culture in a subtle 2; 18 translocation.
Prenatal diagnosis on chorionic villous tissue was performed for a woman with the karyotype 46,XX,t(2;18)(q32;q12)--a subtle 'difficult' translocation. The case illustrates the necessity of good quality cytogenetics for accurate prenatal diagnosis. For chorionic villi this can be obtained only with long-term culture.
Smith
A
A
Cytogenetics Unit, Oliver Latham Laboratory, Department of Health, N.S.W., Australia.
Cohen
M
M
den Dulk
G
G
Guirguis
A
A
D015193:Chorionic Villi Sampling / Q000379:methods*; D002887:Chromosomes, Human, Pair 18; D002889:Chromosomes, Human, Pair 2; D005260:Female; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D013997:Time Factors; D014178:Translocation, Genetic