title: [Giant cell tumors developing in Paget's disease. Presentation of 2 cases with an ultrastructural study].
abstract: We report two cases of giant cell tumor of bone (osteoclastoma) associated with Paget's disease. One appeared on the left cubitus in a 68-year-old male patient while the second involved the right maxillary sinus in a 79-year-old woman. Histopathological study was completed by ultrastructural and immunocytological studies. They were demonstrated to contain intranuclear virus-like filamentous inclusions in the osteoclasts. However, we cannot obtain positive response with antisera against measles virus and respiratory syncitial virus. These data are confronted to the hypothesis for a viral aetiology of Paget's disease and giant cell tumor of bone, associated or not to Paget's disease.
authors.affiliation: Service d'Anatomie Pathologique, Université de Bordeaux II, C.H.R. de Bordeaux.
authors.forename: D
authors.initials: D
authors.lastname: Carles
authors.forename: J
authors.initials: J
authors.lastname: Rivel
authors.forename: F
authors.initials: F
authors.lastname: Devars
authors.forename: J L
authors.initials: JL
authors.lastname: Honton
authors.forename: M F
authors.initials: MF
authors.lastname: Baslé
authors.forename: M
authors.initials: M
authors.lastname: Coquet
authors.forename: J M
authors.initials: JM
authors.lastname: Coindre
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000150:complications* / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D005870:Giant Cell Tumors / Q000150:complications* / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D010001:Osteitis Deformans / Q000150:complications* / Q000473:pathology
vernacular_title: Tumeurs à cellules géantes développées sur une maladie de Paget. Présentation de deux observations avec étude ultrastructurale.