title: Nitrogen-15 NMR studies of rat liver in vitro and in vivo.
abstract: In the present 2.1 T15N NMR study two different kinds of experiments are presented. In one we show that metabolic reactions of 15N-labelled glycine can be followed in the isolated rat liver. In the second we demonstrate that [15N]glycine can be detected using NMR in vivo. For quantification and identification of glycine and metabolites 15N-isotope analysis (emission spectrometry technique) was used. To our knowledge, this is the first demonstration of 15N NMR for study of the metabolism of 15N-labelled compounds in vivo.
authors.affiliation: Sektion Physik der Karl-Marx-Universität Leipzig, GDR.
authors.forename: W
authors.initials: W
authors.lastname: Gründer
authors.forename: P
authors.initials: P
authors.lastname: Krumbiegel
authors.forename: K
authors.initials: K
authors.lastname: Buchali
authors.forename: H J
authors.initials: HJ
authors.lastname: Blesin
mesh_terms: D000818:Animals; D005998:Glycine / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009587:Nitrogen Isotopes; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009587:Nitrogen Isotopes; D005998:Glycine