title: Bioaffinity chromatography: synergy between interactive chromatography and molecular recognition for the separation and analysis of macromolecules.
abstract: Affinity chromatography, commonly regarded as an integral tool in macromolecular separation sciences, also provides an analytical method to study structure-function relationships of macromolecular interaction processes and to design recognition molecules. The latter, as found recently for the case of antisense peptides, may be useful as affinity agents in immobilized forms to effect new types of biomolecular separation.
authors.affiliation: Department of Macromolecular Sciences, Smith Kline and French Research and Development, King of Prussia, PA 19406.
authors.forename: I M
authors.initials: IM
authors.lastname: Chaiken
mesh_terms: D002846:Chromatography, Affinity / Q000379:methods*; D008958:Models, Molecular