Inhibition of rat heart and liver microsomal lipid peroxidation by nifedipine.
Lipid peroxidation in rat heart and liver microsomes was induced by an NADPH-generating system or by ascorbate in the presence of an ADP-iron complex. Microsomal lipid peroxidation, as measured by malonaldehyde formation, was inhibited by nifedipine over a wide range of concentrations (47 microM to 6 mM). Nifedipine also decreased the oxygen consumption of cardiac and hepatic microsomes in a concentration-dependent manner. These results indicate that nifedipine may perturb microsomal electron transport systems. Nifedipine may have the potential to alter the sensitivity of cardiac and hepatic membranes to peroxidative damage.
Engineer
F
F
Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia 29208.
Sridhar
R
R
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008861:Microsomes / Q000187:drug effects* / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D009543:Nifedipine / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D011506:Proteins / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D011506:Proteins; D009249:NADP; D009543:Nifedipine; D001205:Ascorbic Acid