Hypolipemic activity of K12.148 in rats, marmosets and pigs.
The hypolipemic effect of K12.148, a new hypolipemic compound, was examined in normolipemic rats, marmosets and pigs. It could be demonstrated that this compound reduced serum lipids, and in particular serum cholesterol, very effectively in all tested animal species. The analysis of the lipids of the pig give evidence that the hypocholesterolemic effect is due to a reduction of LDL only. In vitro experiments with rat liver homogenates suggest that the hypocholesterolemic effect is brought about by the inhibition of hepatic cholesterol synthesis.
Schliack
M
M
Klinge Pharma GmbH, Department of Biochemical Research, Munich, F.R.G.
Löser
R
R
Seibel
K
K
Blay
K H
KH
D000818:Animals; D000440:Butanols / Q000008:administration & dosage / Q000494:pharmacology*; D002144:Callithrix; D002784:Cholesterol / Q000096:biosynthesis / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D062385:Hydroxybenzoates / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine; D014280:Triglycerides / Q000097:blood*
D000440:Butanols; D008078:Cholesterol, LDL; D062385:Hydroxybenzoates; D014280:Triglycerides; C059343:lifibrol; D002784:Cholesterol