Caffeine pharmacokinetics in preterm infants older than 2 weeks.
We studied 17 preterm infants receiving caffeine, and measured their plasma levels of caffeine and the theophylline metabolite by high-pressure liquid chromatography. The half-life was calculated by computer analysis using the least-square method. The mean gestational age of our patients was 29.7 +/- 1.9 weeks (mean +/- SD) and they were studied at 20.7 +/- 6.6 days (mean +/- SD) postnatal age. The caffeine half-life was 52.03 +/- 23.87 h (means +/- SD) and the theophylline half-life was 77.04 +/- 65.01 h (mean +/- SD).
Pearlman
S A
SA
Department of Pediatrics, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.
Duran
C
C
Wood
M A
MA
Maisels
M J
MJ
Berlin
C M
CM
D002110:Caffeine / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D012891:Sleep Apnea Syndromes / Q000188:drug therapy; D013806:Theophylline / Q000097:blood / Q000378:metabolism
D002110:Caffeine; D013806:Theophylline