title: [Churg-Strauss syndrome: 8 cases in the last 10 years].
abstract: The clinical and histopathological findings of 8 patients with a diagnosis of Churg-Strauss syndrome seen in our institution in a 10 year period have been reviewed. All patients had asthma and hypereosinophilia (mean eosinophil count 7.64 x 10(9); range: 0.748 x 10(9)-31.46 x 10(9) eosinophils/l). The organs and systems involved in the late phase of the syndrome (vasculitic phase) were: nervous system (16 cases), respiratory system (5 cases), skin and subcutaneous tissue (5 cases), heart (3 cases), digestive system (3 cases) and kidney (1 case). The diagnosis was made on the basis of the clinical and histopathological findings. In 7 cases necrotizing angiitis was shown, tissue eosinophilia in 4, and extravascular granulomas in 2. In most cases, corticosteroid therapy resulted in a favorable course, but cyclophosphamide was required in two patients. In the discussion, the evolution of the criteria for the diagnosis of this condition is analyzed.
authors.forename: R
authors.initials: R
authors.lastname: Orriols
authors.forename: A
authors.initials: A
authors.lastname: Román
authors.forename: J
authors.initials: J
authors.lastname: Bosch
authors.forename: G
authors.initials: G
authors.lastname: Sampol
authors.forename: L
authors.initials: L
authors.lastname: Bernadó
authors.forename: F
authors.initials: F
authors.lastname: Morell
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D015267:Churg-Strauss Syndrome / Q000175:diagnosis / Q000188:drug therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013997:Time Factors
chemical_list: D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide
vernacular_title: Síndrome de Churg-Strauss. Ocho casos en los últimos diez años.