Apomorphine-induced inhibition of substantia nigra dopamine neurons: effects of unilateral injection through the internal carotid artery.
Possible indirect components in the inhibition of firing of A9 dopamine neurons induced by systemic apomorphine were studied using unilateral drug administration through the internal carotid artery, known to irrigate only the ipsilateral mid- and forebrain. When compared to intravenous injection, unilateral intracarotid administration inhibited ipsilateral neurons with a marked decrease of both the latency (less than 1 s) and the dose required for complete inhibition, whereas contralateral neurons were not affected. This suggests a first-pass central effect of apomorphine, presumably associated with brain extraction. Thus, peripheral and hindbrain targets do not seem to contribute to the inhibitory effect of low doses of systemic apomorphine. An intranigral possible mode of action is discussed in view of the particular arrangement of dopaminergic dendrites within the zona reticulata.
Akaoka
H
H
INSERM U171-CNRS UA1195, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
Vitte
P A
PA
Lestage
P
P
Saunier
C F
CF
Bobillier
P
P
Chouvet
G
G
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002339:Carotid Arteries; D004298:Dopamine / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D007269:Injections, Intra-Arterial; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*
D001058:Apomorphine; D004298:Dopamine