Sequential model to describe the nicotinic synaptic current.
An analytical formula is derived to describe the synaptic end plate current (epc) at the nicotinic receptor. Various concurrently occurring underlying processes, including (a) diffusion, (b) hydrolysis of acetylcholine, and (c) its binding to the dimeric receptor, were considered in order to develop the equation. Numeric solution of the equations that describe the events underlying the epc showed that these events occur in sequence, rather than concurrently. This sequential occurrence of the processes allowed for simplifications, which were used as the basis for the new description of the epc. The resulting formula serves as a tool for evaluating the relative contribution of the various processes in formation of the natural occurring transient epc.
Parnas
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Otto Loewi Center for Cellular and Molecular Neurobiology Hebrew University of Jerusalem, Israel.
Flashner
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Spira
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ME
D000818:Animals; D003198:Computer Simulation; D007700:Kinetics; D008433:Mathematics; D008959:Models, Neurological; D011978:Receptors, Nicotinic / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
D011978:Receptors, Nicotinic