Investigations on the antiproliferative effects of amino acid antagonists targeting for aminoacyl-tRNA synthetases. Part I--The antibacterial effect.
Amino acid antagonists with proven or potentially inhibitory activities on aminoacyl-tRNA synthetases were tested for their antiproliferative effect against E. coli B. The compounds 4- and 6-fluoro-tryptophan, 5-methyltryptophan, selenocystine and beta-(2-thienyl)alanine gave strong growth inhibition in minimal medium, which disappeared after addition of structurally related natural amino acids or in an enriched broth. The inhibitory effect on amino-acyl-tRNA synthetases and the minimal inhibitory concentration for growth inhibition in minimal medium could not be correlated.
Laske
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R
Schönenberger
H
H
Holler
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E
D000596:Amino Acids / Q000037:antagonists & inhibitors*; D000604:Amino Acyl-tRNA Synthetases / Q000037:antagonists & inhibitors*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*
D000596:Amino Acids; D000604:Amino Acyl-tRNA Synthetases