Chemoprophylaxis of trypanosomiasis, due to Trypanosoma (Nannomonas) congolense, in rabbits using a slow release device containing homidium bromide.
The prophylactic activity of a subcutaneously implanted slow release device, containing homidium bromide, was assessed in rabbits, challenged with different stocks of T. congolense, and compared with the classical treatment of 1 mg homidium bromide/kg b.w. intramuscularly. The prophylactic activity of the intramuscular injection was less than a month, while the slow release device protected the rabbits against seven challenges with T. congolense during a period of more than 300 days.
De Deken
R
R
Geerts
S
S
Kageruka
P
P
Ceulemans
F
F
Brandt
J
J
Schacht
E
E
Pascucci
C
C
Lootens
C
C
D000818:Animals; D002417:Cattle; D003692:Delayed-Action Preparations; D004996:Ethidium / Q000008:administration & dosage* / Q000627:therapeutic use; D011817:Rabbits / Q000469:parasitology; D014348:Trypanosoma congolense / Q000302:isolation & purification; D014354:Trypanosomiasis, Bovine / Q000517:prevention & control*
D003692:Delayed-Action Preparations; D004996:Ethidium