[Effect of captopril on superoxide dismutase (SOD-1) activity and malondialdehyde (MDA) level in blood platelets in patients with arterial hypertension].
18 patients aged 40-50 with diagnosed hypertension (II class by WHO) underwent the study. SOD-1 activity, platelets MDA concentration and degree of platelets aggregation were estimated before and after 1.5 and 24 hours of administration of 12.5 mg captopril single dose. Values of evaluated parameters significantly changed after 1.5 hours of captopril administration: SOD-1 activity increased whereas MDA concentration and platelets aggregation decreased; after 24 hours of drug administration values returned to initial ones. It suggests inhibitory effect of captopril on lipids peroxidation and platelets reactivity.
Tkaczewski
W
W
Kedziora
J
J
Buczyński
A
A
Dziekański
S
S
Ryniec
A
A
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D002216:Captopril / Q000627:therapeutic use*; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008314:Malonates / Q000097:blood*; D008315:Malondialdehyde / Q000037:antagonists & inhibitors / Q000097:blood*; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood*
D008314:Malonates; D008315:Malondialdehyde; D002216:Captopril; D013482:Superoxide Dismutase
Wpływ kaptoprylu na aktywność dysmutazy ponadtlenkowej (SOD-1) oraz stezenie dialdehydu malonowego (MDA) w krwinkach płytkowych u osob z nadciśnieniem tetniczym.