RNA folding: pseudoknots, loops and bulges.
The three-dimensional structures adopted by RNA molecules are crucial to their biological functions. The nucleotides of an RNA molecule interact to form characteristic secondary-structure motifs. Tertiary interactions orient these secondary-structure elements with respect to each other to form the functional RNA. Here we describe the basic structural elements with special emphasis on a novel tertiary motif, the pseudoknot.
Wyatt
J R
JR
Puglisi
J D
JD
Tinoco
I
I
D001483:Base Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D005812:Genes, Switch; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000235:genetics; D012330:RNA, Double-Stranded; D012345:RNA, Transfer, Amino Acid-Specific / Q000235:genetics*; D012360:RNA, Transfer, Phe / Q000235:genetics*
D009841:Oligonucleotides; D012330:RNA, Double-Stranded; D012345:RNA, Transfer, Amino Acid-Specific; D012360:RNA, Transfer, Phe