Effects of fish oil capsules in two dosages on blood pressure, platelet functions, haemorheological and clinical chemistry parameters in apparently healthy subjects.
The effects of a fish oil concentrate with an omega-3 fatty acid content of 42% was determined in two dosages in a double-blind, placebo-controlled study with a parallel group comparison over a period of 5 weeks with 30 healthy subjects. The daily intake chosen was four and eight capsules corresponding to 1.26 or 2.52 g omega-3 fatty acids. Plasma viscosity, erythrocyte rigidity and systolic blood pressure were significantly decreased (p less than 0.01) after a 5-week administration of 2.52 g omega-3 fatty acid daily. The reduction in vitamin E concentration was significant (p less than 0.01) only in the low-dose fish oil group. Lipids and lipoproteins remained unchanged throughout this experiment.
Bach
R
R
Medical Clinic, Department of Internal Medicine III, Homburg/Saar, FRG.
Schmidt
U
U
Jung
F
F
Kiesewetter
H
H
Hennen
B
B
Wenzel
E
E
Schieffer
H
H
Bette
L
L
Heyden
S
S
D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D001794:Blood Pressure; D001809:Blood Viscosity; D002214:Capsules; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004907:Erythrocyte Deformability; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D010974:Platelet Aggregation
D002214:Capsules; D005395:Fish Oils; D008055:Lipids