The effects of dexamethasone on periarticular swelling and joint stiffness following fracture in a rabbit hindlimb model.
An established rabbit hindlimb model was used to determine the effects of systemic steroid administration on posttraumatic limb swelling and joint stiffness. Dexamethasone acetate was administered intramuscularly to the test rabbits in one of four doses two hours following fracture as well as one and two weeks later. Dexamethasone did not produce a significant decrease in swelling but did produce a statistically significant dose-dependent decrease in ankle stiffness compared to controls. Tibia torsional strength to failure was not adversely affected.
Grauer
J D
JD
Wadsworth Veterans Administration Hospital, Los Angeles, CA.
Kabo
J M
JM
Dorey
F J
FJ
Meals
R A
RA
D000818:Animals; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006614:Hindlimb; D007273:Injections, Intramuscular; D007719:Knee Joint / Q000187:drug effects / Q000502:physiology*; D009068:Movement / Q000187:drug effects; D011817:Rabbits; D013978:Tibial Fractures / Q000150:complications* / Q000601:surgery
D003907:Dexamethasone