title: Osteoclast-type giant cell tumor of the endometrium. An immunohistochemical study.
abstract: We present a rare case of a 55 year old female with an osteoclast-type giant cell tumor of the endometrium associated with leiomyoma and adenomyosis. Multinucleated giant cells and mononuclear stromal cells reacted with vimentin and alpha-1-antichymotrypsin (AACT) using the immunoperoxidase method. Epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), and keratin exhibited negative immunoreaction in these tumor cells. Our immunohistochemical results do not support the epithelial origin of an osteoclast-type giant cell tumor and mesenchymal derivation appeared more likely, suggesting histiocytic origin.
authors.affiliation: Department of Pathology, Nagasaki University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kawai
authors.forename: M
authors.initials: M
authors.lastname: Senba
authors.forename: H
authors.initials: H
authors.lastname: Tagawa
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Matsuo
authors.forename: H
authors.initials: H
authors.lastname: Tsuchiyama
mesh_terms: D005260:Female; D005870:Giant Cell Tumors / Q000032:analysis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology; D014594:Uterine Neoplasms / Q000032:analysis* / Q000209:etiology / Q000473:pathology; D014746:Vimentin / Q000032:analysis; D000514:alpha 1-Antichymotrypsin / Q000032:analysis
chemical_list: D014746:Vimentin; D000514:alpha 1-Antichymotrypsin