Superwarfarin poisoning.
Superwarfarins consist of two classes of compounds, the 4-hydroxycoumarins and the indandiones. These compounds have replaced warfarin as an anticoagulant rodenticide. This article is a summary of the clinical effects produced by accidental and deliberate ingestions of superwarfarins. Most accidental ingestions occur in childhood and result in a benign outcome. Deliberate overdoses usually involve repeated ingestions of large quantities of superwarfarins that have resulted in prolonged laboratory evidence of interference with clotting; serious bleeding has been rare. This article suggests an approach to the management of patients with accidental and deliberate anticoagulant rodenticide ingestions.
Katona
B
B
Department of Pharmacy, Francis Scott Key Medical Center, Baltimore, MD.
Wason
S
S
D015110:4-Hydroxycoumarins / Q000506:poisoning; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D012378:Rodenticides / Q000506:poisoning*
D015110:4-Hydroxycoumarins; D012378:Rodenticides