title: The nasopharyngeal bacterial flora in the sudden infant death syndrome.
abstract: The nasopharyngeal bacterial flora in babies who had died of the sudden infant death syndrome (SIDS) (n = 46) and in healthy infants aged 2 weeks to 6 months (n = 46) is described. Of those who had died, 41.3% carried Staphylococcus aureus (95% confidence limits: 27.3-55.3%) compared with 28.3% of healthy infants (95% confidence limits: 15.3-41.3%). The isolation rate of streptococci was 78.3% in cases (95% confidence limits: 66.4-90.2%) and 32.6% in healthy infants (95% confidence limits: 19.1-46.1%) (significant difference P less than 0.0001). Enterobacteria were isolated from 45.6% of cases (95% confidence limits: 31.2-60%) but only 2.2% of healthy infants (95% confidence limits 0-6.4%) (significant difference, P less than 0.0001). These results indicate a disordered nasopharyngeal flora in SIDS. They also provide baseline data for investigating the hypothesis that common bacterial toxins are involved in the pathogenesis of SIDS.
authors.affiliation: Lancaster Moor Hospital, U.K.
authors.forename: D R
authors.initials: DR
authors.lastname: Telford
authors.forename: J A
authors.initials: JA
authors.lastname: Morris
authors.forename: P
authors.initials: P
authors.lastname: Hughes
authors.forename: A R
authors.initials: AR
authors.lastname: Conway
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: A J
authors.initials: AJ
authors.lastname: Barson
authors.forename: D B
authors.initials: DB
authors.lastname: Drucker
mesh_terms: D001419:Bacteria / Q000302:isolation & purification*; D001427:Bacterial Toxins / Q000032:analysis; D004755:Enterobacteriaceae / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009305:Nasopharynx / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013291:Streptococcus / Q000302:isolation & purification; D013398:Sudden Infant Death / Q000382:microbiology*
chemical_list: D001427:Bacterial Toxins