Influence of urography on renal function in children. A double blind study with metrizoate and iohexol.
Thirty-two children were given either metrizoate or iohexol for urography in a double blind study. Mild to moderate adverse reactions were observed in all patients receiving metrizoate (15/15) and in 4 receiving iohexol (4/17). Alkaline phosphatase in urine was significantly increased 4 hours after the injection of both media, but had returned to pre-injection levels 16 hours later. The excretion of beta 2-microglobulin and albumin was not altered. In 9 children in the metrizoate group and 11 in the iohexol group the glomerular filtration rate (GFR) was determined before urography by the single injection 99Tcm-DTPA-technique and 3 to 4 hours after urography by measuring the plasma disappearance of the contrast medium with the x-ray fluorescence technique. No reduction of GFR was observed.
Stake
G
G
Department of Pediatric Radiology, University Hospital, Oslo, Norway.
Monn
E
E
Rootwelt
K
K
Golman
K
K
Monclair
T
T
D000293:Adolescent; D000419:Albuminuria / Q000139:chemically induced; D000469:Alkaline Phosphatase / Q000652:urine; D002648:Child; D003404:Creatinine / Q000097:blood / Q000652:urine; D004311:Double-Blind Method; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007223:Infant; D007463:Iodobenzoates / Q000009:adverse effects*; D007472:Iohexol / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008794:Metrizoic Acid / Q000009:adverse effects*; D014567:Urography / Q000009:adverse effects*; D001613:beta 2-Microglobulin / Q000652:urine
D007463:Iodobenzoates; D001613:beta 2-Microglobulin; D007472:Iohexol; D003404:Creatinine; D008794:Metrizoic Acid; D000469:Alkaline Phosphatase