title: Relationship between milk composition and pup's growth in mice.
abstract: The effect of lactation numbers (first, second, and third) on milk composition and the relationship between milk composition and pup's growth were examined in four strains of mice (SHN, SLN, C3H/He, and GR/A). Although the percentage of milk fat and moisture increased and decreased, respectively, through the first to third lactations in C3H/He mice, no differences in milk composition among lactation numbers were observed in the other mouse strains. In pooled data derived from the four strains of mice, there was no significant correlation between milk composition and body weight or growth rate of pups on Day 12 or 20 of the first lactation. In contrast, the amount of milk fat and moisture was the positively and negatively, respectively, correlated with the pup's growth parameters during the second and third lactations. This was reflected by a lower fat content and a higher moisture content in the milk of GR/A mice, especially evident during the second and third lactations and reduced pup's growth, when compared with the other mouse strains. Milk lactose and ash content was not correlated with pup's growth parameters. The results of our study stress the importance of milk fat for the growth of mouse pups.
authors.affiliation: Experimental Animal Research Laboratory, Meiji University, Kanagawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nagasawa
authors.forename: T
authors.initials: T
authors.lastname: Naito
authors.forename: K
authors.initials: K
authors.lastname: Kataoka
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001835:Body Weight; D005260:Female; D007774:Lactation; D008055:Lipids / Q000032:analysis; D051379:Mice; D008809:Mice, Inbred C3H; D008892:Milk / Q000032:analysis*; D011247:Pregnancy; D013045:Species Specificity
chemical_list: D008055:Lipids