Protooncogene structure in the cancer family syndrome.
Protooncogene loci in constitutional DNA from affected members of a kindred with the cancer family syndrome were studied by Southern blot hybridization analysis. No structural rearrangements or amplification of 16 protooncogenes were detected. These studies demonstrated that gross structural alteration of the tested protoocongenes is not responsible for cancer susceptibility in this syndrome.
Loughran
A
A
Department of Medicine, State University of New York, Stony Brook 11794-8174.
Johnson
B
B
Tierney
J
J
Viola
M V
MV
D002874:Chromosome Mapping; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D006801:Humans; D009154:Mutation; D011519:Proto-Oncogenes