Zidovudine-related mania.
Two patients with the acquired immunodeficiency syndrome (AIDS), who had no past psychiatric history, developed a mania-like illness soon after commencing treatment with zidovudine. The neurotoxic effects of zidovudine have been described previously, but to our knowledge no reports of a psychiatric disorder that is related to the drug have appeared. Our report emphasizes the need to monitor patients with AIDS for neuropsychiatric problems.
Wright
J M
JM
Prince Henry Hospital, Little Bay, NSW.
Sachdev
P S
PS
Perkins
R J
RJ
Rodriguez
P
P
D000328:Adult; D001714:Bipolar Disorder / Q000139:chemically induced*; D006679:HIV Seropositivity / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015215:Zidovudine / Q000009:adverse effects*
D015215:Zidovudine