[Dependence of the radioprotective effect of beta-mercaptoethylamine on the thiol level of the outer cell membrane].
In experiments with Ehrlich ascites tumor cells with the use of a specific thiol blocker, 6,6'-dithiodinicotinic acid, it was shown that thiols of a cell plasmic membrane are necessary for the radioprotective effect of mercaptoethylamine to be realized.
Konstantinova
M M
MM
Dontsova
G V
GV
Koroleva
N M
NM
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism* / Q000532:radiotherapy; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D002869:Chromosome Aberrations; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D008624:Mercaptoethylamines / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009539:Nicotinic Acids / Q000494:pharmacology; D011837:Radiation-Protective Agents; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013439:Sulfhydryl Reagents / Q000494:pharmacology; D013997:Time Factors; D014407:Tumor Cells, Cultured
D008624:Mercaptoethylamines; D009539:Nicotinic Acids; D011837:Radiation-Protective Agents; D013438:Sulfhydryl Compounds; D013439:Sulfhydryl Reagents; C001102:6,6'-dithiodinicotinic acid
Zavisimost' radiozashchitnogo éffekta beta-merkaptoétilamina ot urovnia tiolov naruzhnoĭ kletochnoĭ membrany.