Fungitoxicity of m-fluorophenylalanine-containing peptides towards Pythium ultimum.
The tripeptide L-m-fluorophenylalanyl-L-alanyl-L-alanine was much more fungitoxic towards Pythium ultimum than the dipeptide L-m-fluorophenylalanyl-L-alanine or m-fluorophenylalanine. The fungitoxicity of the tripeptide was reduced by L-alanyl peptides and phenylalanine, but not by other amino acids. In contrast, the fungitoxicity of m-fluorophenylalanine was unaffected by peptides, and was antagonized by several amino acids. These results suggest the effective delivery of m-fluorophenylalanine into the cell by a tripeptide carrier.
Young
D H
DH
Rohm and Haas Co., Research Laboratories, Spring House, Pennsylvania 19477.
Mehta
R J
RJ
D000409:Alanine / Q000494:pharmacology; D000596:Amino Acids / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D008411:Chytridiomycota / Q000187:drug effects*; D004151:Dipeptides / Q000494:pharmacology; D009842:Oligopeptides / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology; D011775:Pythium / Q000187:drug effects* / Q000378:metabolism
D000596:Amino Acids; D000935:Antifungal Agents; D004151:Dipeptides; D009842:Oligopeptides; C027218:3-fluorophenylalanine; D010649:Phenylalanine; C059347:3-fluorophenylalanyl-alanyl-alanine; D000409:Alanine