Reduction potentials of anthelmintic drugs: possible relationship to activity.
Electrochemical data were acquired for several categories of anthelmintic agents, namely, iminium-type ions, metal derivatives and chelators, quinones and iminoquinones, and nitroheterocycles. Reductions usually were in the favorable range of +0.2 to -0.7 V versus normal hydrogen electrode. The drug effect is believed to result in part from either the catalytic production of oxidative stress or disruption of helminth electron transport systems. Relevant literature results are discussed.
Kovacic
P
P
Department of Chemistry, University of Wisconsin-Milwaukee 53201.
Ames
J R
JR
Rector
D L
DL
Jawdosiuk
M
M
Ryan
M D
MD
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology; D000965:Antimony; D001151:Arsenic / Q000494:pharmacology; D001562:Benzimidazoles / Q000494:pharmacology; D001645:Biguanides / Q000494:pharmacology; D002251:Carbon Tetrachloride / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004396:Coloring Agents / Q000494:pharmacology; D004563:Electrochemistry; D006376:Helminths / Q000187:drug effects; D006835:Hydrazones / Q000494:pharmacology; D009574:Nitro Compounds / Q000494:pharmacology; D010084:Oxidation-Reduction; D010545:Peroxides / Q000494:pharmacology; D010640:Phenothiazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011809:Quinones / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000871:Anthelmintics; D001562:Benzimidazoles; D001645:Biguanides; D004396:Coloring Agents; D006835:Hydrazones; D009574:Nitro Compounds; D010545:Peroxides; D010640:Phenothiazines; D011725:Pyridines; D011809:Quinones; D000965:Antimony; D002251:Carbon Tetrachloride; C031637:phenothiazine; D001151:Arsenic