title: Transabdominal ultrasonography plus urine cytology in control of benign bladder tumours.
abstract: Transabdominal ultrasonography can detect bladder tumours down to 5 mm in diameter, and in combination with urine cytology it is a potential alternative to cystoscopy for control of bladder tumour patients. This modality was compared with cystoscopy in 260 investigations on patients with previous non-invasive tumours. Of 153 negative ultrasonographies 55 (21%) were false negative, overlooking 15 tumours above 5 mm (including 5 flat papillomatous areas), 30 tumours 5 mm or less and 10 flat dysplastic lesions (diagnostic sensitivity 64%). In 14 of the false negative ultrasonographies urine cytology was abnormal, increasing the combined diagnostic sensitivity to 73%. Most overlooked tumours above 5 mm were in bladder neck, anterior wall and dome. Of 89 positive ultrasonographies 15 were false positive (diagnostic specificity 83%). Two patients developed invasive tumours in the study period. One was detected by ultrasound and urine cytology, the other - a flat muscle invasive tumour - was not. Ultrasonography plus urine cytology is only acceptable for control of patients with very little risk of invasive and few non-invasive recurrences, i.e. patients with previous Ta, grade I or II transitional cell tumours and no recurrences after 1 or 2 control cystoscopies.
authors.affiliation: Department of Abdominal Surgery, Aarhus, Denmark.
authors.forename: S E
authors.initials: SE
authors.lastname: Petersen
authors.forename: F
authors.initials: F
authors.lastname: Lundbeck
authors.forename: O
authors.initials: O
authors.lastname: Brandsborg
authors.forename: V
authors.initials: V
authors.lastname: Steensskov
authors.forename: P
authors.initials: P
authors.lastname: Siem-Jørgensen
authors.forename: N
authors.initials: N
authors.lastname: Harving
authors.forename: H
authors.initials: H
authors.lastname: Wolf
mesh_terms: D000005:Abdomen; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography / Q000379:methods*; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*; D014556:Urine / Q000166:cytology*