[Effect of prostaglandin E2 on the development of myocardial damage in rats with various resistance to hypoxia].
Experiments conducted on male rats with congenital high and low resistance to hypoxia (HH and LH, respectively) have revealed, that injection of prostaglandin E2 (PHE2) 15 min before the injection of adrenalin essentially decreases the activity of lipid peroxidation in myocardium as compared with animals which have been injected to only adrenalin. This modulative effect (PHE2) on the action of adrenalin was more pronounced in LH-rats. Consequently, the activity of the prostaglandin stress-limiting system determines to a great extent the organism resistance to hypoxia.
Markova
E A
EA
Misula
I R
IR
Datsko
A I
AI
D000818:Animals; D009202:Cardiomyopathies / Q000517:prevention & control*; D015232:Dinoprostone / Q000494:pharmacology*; D004837:Epinephrine / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000860:Hypoxia / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats
D015232:Dinoprostone; D004837:Epinephrine
Vliianie prostaglandina E2 na razvitie adrenalinovogo povrezhdeniia miokarda u krys s razlichnoĭ ustoĭchivost'iu k gipoksii.