title: Musculoskeletal neoplasms: static and dynamic Gd-DTPA--enhanced MR imaging.
abstract: Static and dynamic magnetic resonance imaging studies were performed in 69 patients with bone and soft-tissue tumors. T1-weighted spin-echo (SE) imaging after intravenous administration of gadolinium diethylenetriaminepentaacetic acid (DTPA) improved the differentiation of necrotic from viable areas; the contrast-to-noise ratio (C/N) between tumor and muscle was an average of 44% lower compared with that in T2-weighted SE imaging. The C/N between tumor and bone marrow or fatty tissue was 43% and 37% lower, respectively, compared with that in nonenhanced T1-weighted SE imaging. Dynamic changes of signal intensity (SI) after Gd-DTPA enhancement were assessed with fast low-angle shot imaging. Of malignant tumors, 84.1% exhibited slopes higher than 30% per minute; 72% of benign tumors showed slopes lower than 30% per minute. The dynamic technique enabled assessment of the malignant potential of a tumor with some overlap (accuracy, 79.7%). Necrotic areas and peritumorous edema showed significantly lower and more gradual increases in SI than adjacent neoplastic tissue.
authors.affiliation: Department of Clinical Radiology, Westfälischen Wilhelms-Universität, Munster, Federal Republic of Germany.
authors.forename: R
authors.initials: R
authors.lastname: Erlemann
authors.forename: M F
authors.initials: MF
authors.lastname: Reiser
authors.forename: P E
authors.initials: PE
authors.lastname: Peters
authors.forename: P
authors.initials: P
authors.lastname: Vasallo
authors.forename: B
authors.initials: B
authors.lastname: Nommensen
authors.forename: C R
authors.initials: CR
authors.lastname: Kusnierz-Glaz
authors.forename: J
authors.initials: J
authors.lastname: Ritter
authors.forename: A
authors.initials: A
authors.lastname: Roessner
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000175:diagnosis*; D004487:Edema / Q000175:diagnosis; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000175:diagnosis; D009336:Necrosis / Q000175:diagnosis; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011446:Prospective Studies; D012983:Soft Tissue Neoplasms / Q000175:diagnosis*
chemical_list: D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA