Low molecular weight immunosuppressors secreted by adult Nematospiroides dubius.
Adult Nematospiroides dubius excretory-secretory products (ES) were collected from worms cultured in vitro, separated by sodium dodecyl sulphate--polyacrylamide gel electrophoresis (SDS-PAGE) into four fractions (FI-IV), electroeluted and assessed for their ability to inhibit the proliferation of mouse lymphocytes stimulated by mitogens in vitro. The proliferation of mitogen- and ES-stimulated mouse spleen lymphocytes from normal and infected mice was inhibited by low mol. wt ES F-IV (less than 26,000).
Monroy
F G
FG
Dobson
C
C
Adams
J H
JH
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D005260:Female; D006369:Heligmosomatoidea / Q000276:immunology*; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D009351:Nematospiroides dubius / Q000276:immunology*
D000947:Antigens, Helminth