Regulation of new fat cell formation.
The formation of new adipocytes occurs either at the stage of multiplication or differentiation or both. It seems possible that the formation of new fat cells is dependent on the average cell weight in a given adipose tissue depot, but there may also be other regional, local regulatory factors. Multiplication of fat cells has been suggested to be stimulated by 17-beta-oestradiol while the differentiation of adipocytes is stimulated by growth hormone, glucocorticoids, insulin, insulin-like growth factor and female sex hormones. There are, probably, other factors acting in circulation or locally. The factors promoting growth of new fat cells with overfeeding are at present unknown. Some hypothetical possibilities are discussed.
Sypniewska
G
G
Department of Clinical Nutrition, National Institute of Food and Nutrition, Warsaw.
D000273:Adipose Tissue / Q000166:cytology* / Q000187:drug effects / Q000254:growth & development; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology / Q000502:physiology; D006133:Growth Substances / Q000494:pharmacology / Q000502:physiology; D006728:Hormones / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects
D006133:Growth Substances; D006728:Hormones; D004958:Estradiol