title: Mononuclear phagocytes and the human immunodeficiency virus.
abstract: Macrophages are an important in vivo reservoir for HIV. Conclusive evidence that CNS, pulmonary, lymph node and blood-derived mononuclear phagocytes harbor and support HIV replication is supported by numerous independent studies. HIV variants which preferentially replicate in macrophages have been recovered from infected individuals, suggesting that these cells and variant viruses are involved in the establishment and progression of HIV-related disease.
authors.affiliation: Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland.
authors.forename: H E
authors.initials: HE
authors.lastname: Gendelman
authors.forename: M S
authors.initials: MS
authors.lastname: Meltzer
mesh_terms: D001685:Biological Factors / Q000502:physiology; D002478:Cells, Cultured; D016207:Cytokines; D015967:Gene Expression Regulation, Viral; D006678:HIV / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D015658:HIV Infections / Q000473:pathology; D006801:Humans; D008262:Macrophage Activation; D008264:Macrophages / Q000382:microbiology* / Q000473:pathology; D009000:Monocytes / Q000382:microbiology / Q000473:pathology; D014776:Virus Cultivation; D014779:Virus Replication
chemical_list: D001685:Biological Factors; D016207:Cytokines