Quantification of the effects of chlorpromazine on performance under delayed matching to sample in pigeons.
The effects of four doses of chlorpromazine (dose range 0.5 to 12.5 mg/kg) on performance under a delayed matching-to-sample procedure in pigeons was investigated, using the exponential model of memory (White, 1985). Performance was measured using a bias-free measure of discriminability, log d (Davison & Tustin, 1978), and negative exponential functions were fitted to individual-subject and group data at each dose level. A decrease in matching accuracy was found to be caused by an increase in the rate of forgetting, b, and a decrease in the initial discriminability, log d0. Changes in rate of forgetting and discriminability occurred at doses that had no statistically significant effect on response latency. The exponential model of memory accounted well for the data and provided a useful way of quantifying the effects of chlorpromazine on the processes involved in delayed matching-to-sample performance.
Watson
J E
JE
Rhode Island Hospital, Brown University, Providence 02903.
Blampied
N M
NM
D000818:Animals; D001288:Attention / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology*; D003118:Color Perception / Q000187:drug effects*; D010856:Columbidae; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects
D002746:Chlorpromazine