Kinetics of drug decomposition by heat conduction calorimetry.
The application of heat conduction calorimetry to the determination of decomposition mechanisms and rates for drugs is shown to be a rapid and generally useful method. The application of the method to determine the nature of the decomposition reaction, sources of systematic errors in the method, the equations relating the calorimetric signal to the kinetics of the reaction, and some examples of results are presented and discussed.
Hansen
L D
LD
Department of Chemistry, Brigham Young University, Provo, Utah 84602.
Lewis
E A
EA
Eatough
D J
DJ
Bergstrom
R G
RG
DeGraft-Johnson
D
D
D002151:Calorimetry; D004355:Drug Stability; D008956:Models, Chemical; D013696:Temperature