Inhibitory histamine H3-receptors on cholinergic nerves in human airways.
The histamine H3-agonist, (R)-alpha-methylhistamine (alpha-MeHA) caused a dose-dependent inhibition of cholinergic contractile responses to electrical field stimulation in human bronchi without affecting the basal tone. alpha-MeHA, but, did not alter the response to acetylcholine. Blockade of H1- and H2-receptors, or alpha- and beta-adrenoceptors failed to prevent the inhibitory effect of alpha-MeHA, whereas the specific H3-antagonist, thioperamide, was effective. Our results indicate that H3-receptors modulate cholinergic neurotransmission in human airways.
Ichinose
M
M
Department of Thoracic Medicine, National Heart and Lung Institute, London, U.K.
Barnes
P J
PJ
D000109:Acetylcholine / Q000494:pharmacology; D000328:Adult; D000368:Aged; D001980:Bronchi / Q000187:drug effects / Q000294:innervation; D004558:Electric Stimulation; D006801:Humans; D066298:In Vitro Techniques; D008761:Methylhistamines / Q000494:pharmacology; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009474:Neurons / Q000502:physiology*; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D011968:Receptors, Histamine / Q000187:drug effects*
D008761:Methylhistamines; D011968:Receptors, Histamine; D000109:Acetylcholine; C048140:N-methylhistamine