[Clinical significance of the determination of serum fructosamine and albumin in children with diabetes mellitus].
The paper is devoted to a study of the role of serum glycoprotein fructosamine and serum albumin in the pathogenesis of a severe course of insulin dependent diabetes mellitus (IDDM) in children. Fructosamine was determined in 43 pediatric patients with IDDM by direct spectrophotometry using Hoffman-La-Roche kits; albumin, C-peptide and malonic aldehyde were also determined. Disorder of the mechanism of regulation of homeostasis by albumin was shown to play an important role in the pathogenesis of a severe course of IDDM in children. It could be caused by its enhanced glycosylation and a decrease in liver synthesis in some cases as a result of considerable reduction of insulin secretion. A prognostically unfavorable sign was a raised ratio of fructosamine to albumin and enhanced lipid peroxidation against a background of low insulin secretion. The determination of serum levels of fructosamine and albumin can be a valuable diagnostic criterion in examination of children with diabetes mellitus.
Vakhrusheva
L L
LL
Kniazev
Iu A
IuA
Sergeeva
N A
NA
Martynova
M I
MI
Chesnokova
T T
TT
D015415:Biomarkers / Q000097:blood; D002096:C-Peptide / Q000097:blood; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D019270:Fructosamine; D006595:Hexosamines / Q000097:blood*; D006706:Homeostasis; D006801:Humans; D008099:Liver / Q000378:metabolism; D008315:Malondialdehyde / Q000097:blood; D011379:Prognosis; D012709:Serum Albumin / Q000032:analysis*
D015415:Biomarkers; D002096:C-Peptide; D006595:Hexosamines; D012709:Serum Albumin; D019270:Fructosamine; D008315:Malondialdehyde
Klinicheskoe znachenie opredeleniia fruktozamina i al'bumina syvorotki krovi pri sakharnom diabete u deteĭ.