Nocardia infection in the acquired immunodeficiency syndrome.
A case of Nocardia asteroides pneumonia in a patient with the acquired immunodeficiency syndrome who was intolerant of sulfadiazine is described. On cefuroxime, the patient had a complete resolution of his Nocardia pneumonia. Disk-diffusion and broth microdilution antibiotic susceptibility testing (MIC less than or equal to 2 micrograms/ml) strongly supported the use of cefuroxime as treatment in this patient. Susceptibility testing with newer cephalosporins should be considered for all significant Nocardia isolates.
Telzak
E E
EE
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Hii
J
J
Polsky
B
B
Kiehn
T E
TE
Armstrong
D
D
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D002444:Cefuroxime / Q000494:pharmacology / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009617:Nocardia Infections / Q000150:complications* / Q000188:drug therapy; D009616:Nocardia asteroides / Q000187:drug effects / Q000302:isolation & purification; D009894:Opportunistic Infections / Q000150:complications* / Q000188:drug therapy; D011014:Pneumonia / Q000150:complications* / Q000188:drug therapy; D013183:Sputum / Q000382:microbiology; D013411:Sulfadiazine / Q000009:adverse effects / Q000627:therapeutic use
D002511:Cephalosporins; D013411:Sulfadiazine; D002444:Cefuroxime