title: Release of acetylcholinesterase from the guinea-pig substantia nigra during peripheral nerve stimulation.
abstract: A soluble form of acetylcholinesterase is released from the substantia nigra in both a spontaneous and drug-induced fashion. The aim of this study was to see whether this phenomenon was also sensitive to a non-pharmacological event. During electrical stimulation of the intact sciatic nerve, there was an increase in the activity of acetylcholinesterase, measured in perfusates of the guinea-pig substantia nigra in vivo. This increase was not due to spontaneous fluctuations in acetylcholinesterase release, plasma contamination, tissue damage or release of acetylcholinesterase from a non-specific site. The possible pathways mediating this phenomenon are discussed.
authors.affiliation: University Laboratory of Pharmacology, Oxford, U.K.
authors.forename: S J
authors.initials: SJ
authors.lastname: Taylor
authors.forename: S A
authors.initials: SA
authors.lastname: Greenfield
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D006168:Guinea Pigs; D012584:Sciatic Nerve / Q000502:physiology*; D013378:Substantia Nigra / Q000201:enzymology* / Q000502:physiology; D013997:Time Factors
chemical_list: D000110:Acetylcholinesterase