Application of adsorptive stripping voltammetry to the study of immunoglobulin A and its interaction with benzodiazepine drugs.
The adsorptive stripping voltammetric behaviour of immunoglobulin A has been optimised with respect to accumulation time, accumulation potential, scan rate and drop size and its interaction with benzodiazepine drugs in 0.05 M phosphate buffer (pH 7.4) has been studied. Immunoglobulin A was observed to form a strongly reducible complex with diazepam and a labile non-reducible complex with flurazepam.
Rodríguez
J
J
Vinagre
F
F
Borrachero
A
A
Sánchez
A
A
D001569:Benzodiazepines / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D004563:Electrochemistry; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*
D007070:Immunoglobulin A; D001569:Benzodiazepines