Intracranial microinfusion of pancreastatin elevates blood glucose, free fatty acids, and corticosterone in rats.
Pancreastatin, a novel peptide recently isolated from porcine pancreas, significantly inhibits insulin and somatostatin release and augments glucagon release from the isolated perfused rat pancreas. This implies a role for endogenous pancreatic pancreastatin in the regulation of blood glucose and free fatty acids, the two major metabolic fuels. Since many peptides have similar biological effects when administered centrally and peripherally, the effects of centrally administered pancreastatin on blood glucose and free fatty acids were examined in 3 studies. Corticosterone was also measured in two of these studies. Intraventricular microinfusion of pancreastatin significantly elevated blood glucose, free fatty acid, and corticosterone concentrations in a dose-related manner. None of these effects was seen after subcutaneous injection of the same doses. Centrally administered pancreastatin appears to produce its effects on glucose and free fatty acids through actions in the brain, and either the brain, the median eminence, and/or pituitary for corticosterone.
Gunion
M W
MW
Geriatric Research, Education, and Clinical Center, Sepulveda Veterans Administration Medical Center, CA 91343.
Rosenthal
M J
MJ
Tatemoto
K
K
Morley
J E
JE
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D053379:Chromogranin A; D003345:Corticosterone / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000097:blood*; D008297:Male; D008845:Microinjections; D010187:Pancreatic Hormones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001786:Blood Glucose; D053379:Chromogranin A; D005227:Fatty Acids; D010187:Pancreatic Hormones; C050836:pancreastatin; D003345:Corticosterone