title: Mercury induced time-dependent alterations in lipid profiles and lipid peroxidation in different body organs of cat-fish Heteropneustes fossilis.
abstract: The effects of mercuric chloride (HgCl2) on lipid profiles and lipid peroxidation in different body organs of fresh water cat-fish Heteropneustes fossilis were studied. The daily exposure of HgCl2 0.2 mg/L for 10, 20 and 30 days depleted the total lipids in brain. But the content of phospholipids enhanced significantly at 30 days. Significant diminution in C/P ratio was discernible with 30 days of exposure following mercury toxicosis. Liver exhibited elevated levels of total lipids, phospholipids, cholesterol and C/P ratio. Interestingly kidney showed marked decrease in the concentration of total lipids, cholesterol and C/P ratio at higher exposure. However, the phospholipid values increased during the longer exposure. The content of total lipids and phospholipids was high in muscle but the level of cholesterol and C/P ratio were depleted. Significant increment in lipid peroxidation was discernible in brain, liver and muscle. In kidney the rate of lipid peroxidation was significantly reduced. The results suggest that exposure of HgCl2 enhances the peroxidation of endogenous lipids in brain, liver and muscle. Interestingly the lipid contents are affected differently in different body organs.
authors.affiliation: Interdisciplinary Brain Research Centre, Jawaharlal Nehru Medical College, Aligarh Muslim University, India.
authors.forename: Y
authors.initials: Y
authors.lastname: Bano
authors.forename: M
authors.initials: M
authors.lastname: Hasan
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects; D002397:Catfishes / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects; D008627:Mercuric Chloride / Q000633:toxicity*; D009132:Muscles / Q000187:drug effects; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D008055:Lipids; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D008627:Mercuric Chloride