title: Liposomes as cyclosporin A carriers: positively charged lecithin-cholesterol liposomes associated with cyclosporin A do not inhibit biosynthesis of mitochondrial polyglycerophosphatides and microsomal phosphatidylinositol.
abstract: Phosphatidylcholine (from egg yolk)-cholesterol-stearylamine (7:2:2.25, molar ratio) liposomes when associated with cyclosporin A (phosphatidylcholine:cyclosporin A = 2:0.07, molar ratio) do not inhibit significantly the biosynthesis of [3H]polyglycerophosphatides and [3H]phosphatidylinositol in mitochondrial and microsomal membranes, respectively, isolated from rat liver. These results are explained by possible protection of the liposomes by cyclosporin A against phospholipase A2 hydrolysis.
authors.affiliation: Department of Clinical Biochemistry, Banting Institute, Faculty of Medicine, University of Toronto, Ontario, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Stuhne-Sekalec
authors.forename: N Z
authors.initials: NZ
authors.lastname: Stanacev
mesh_terms: D000588:Amines / Q000008:administration & dosage / Q000494:pharmacology; D002784:Cholesterol / Q000008:administration & dosage / Q000494:pharmacology*; D003524:Cyclosporins / Q000008:administration & dosage*; D004337:Drug Carriers; D008081:Liposomes; D008861:Microsomes / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000494:pharmacology*; D010715:Phosphatidylglycerols / Q000096:biosynthesis*; D010716:Phosphatidylinositols / Q000096:biosynthesis*
chemical_list: D000588:Amines; D003524:Cyclosporins; D004337:Drug Carriers; D008081:Liposomes; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D010716:Phosphatidylinositols; C034358:phosphatidylglycerophosphate; D002784:Cholesterol; C009317:stearylamine