title: Isolation and primary structure of rat secretin.
abstract: A major form of rat secretin was purified to homogeneity from small intestine, being detected with a porcine secretin radioimmunoassay throughout 7 chromatographic steps. The sequence of the heptacosapeptide amide H-S-D-G-T-F-T-S-E-L-S-R-L-Q-D-S-A-R-L-Q-R-L-L-Q-G-L-V-NH2 shows that rat secretin has a glutamine residue in position 14 instead of arginine as in pig secretin.
authors.affiliation: Department of Biochemistry and Nutrition, Medical School, Université Libre de Bruxelles, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Gossen
authors.forename: A
authors.initials: A
authors.lastname: Vandermeers
authors.forename: M C
authors.initials: MC
authors.lastname: Vandermeers-Piret
authors.forename: J
authors.initials: J
authors.lastname: Rathé
authors.forename: A
authors.initials: A
authors.lastname: Cauvin
authors.forename: P
authors.initials: P
authors.lastname: Robberecht
authors.forename: J
authors.initials: J
authors.lastname: Christophe
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D004285:Dogs; D006801:Humans; D007421:Intestine, Small / Q000032:analysis*; D008969:Molecular Sequence Data; D051381:Rats; D011919:Rats, Inbred Strains; D012633:Secretin / Q000302:isolation & purification*; D012689:Sequence Homology, Nucleic Acid; D013552:Swine
chemical_list: D012633:Secretin