title: Survival of a child despite unusually high blood ethanol levels.
abstract: A 30-month-old, 13-kg child reportedly ingested up to 16 ounces of a wine containing 20% ethanol. The child was brought into the emergency department by paramedics, and upon arrival was found to be comatose and unresponsive to deep stimuli but breathing spontaneously. The patient remained unconscious and unresponsive for three hours after admission. Despite an initial blood ethanol level of 98.78 mmol/L (455 mg/dL), recovery was complete without sequelae. Treatment consisted of prompt gastric decontamination and maintenance of adequate hydration and euglycemia. Elimination of ethanol was rapid in this child and appeared to follow first-order kinetics instead of the zero-order kinetics usually observed. To our knowledge, this is the highest initial blood ethanol level reported in a child with survival. Additionally, no significant metabolic or cardiorespiratory derangement occurred. Ethanol toxicity, elimination kinetics, and treatment are discussed.
authors.affiliation: Pittsburgh Poison Center, Children's Hospital of Pittsburgh.
authors.forename: G P
authors.initials: GP
authors.lastname: Lopez
authors.forename: D M
authors.initials: DM
authors.lastname: Yealy
authors.forename: E P
authors.initials: EP
authors.lastname: Krenzelok
mesh_terms: D000061:Accidents, Home; D000435:Alcoholic Intoxication / Q000097:blood / Q000628:therapy*; D002675:Child, Preschool; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics; D005751:Gastric Lavage; D006801:Humans; D007700:Kinetics; D008297:Male
chemical_list: D000431:Ethanol