Comparison of different radioactive renal agents in cisplatin-induced tubular toxicity in rats.
The efficacy of five different radiodiagnostic agents for detecting renal tubular dysfunction induced with cisplatin in rats was compared to controls. Diethylenetriaminepentaacetic acid (DTPA) labeled with 99mTc or 111In was administered simultaneously with each of the other four agents [99mTc]glucoheptonate, [99mTc]dimercaptosuccinic acid, [131I]hippuran and [111In]lysozyme) as a standard to normalize for differences in functional impairment from animal to animal from the same dose of cisplatin. The 2-hr plasma clearance and computer-generated 2- to 3-min uptake in the two kidneys with [99mTc]dimercaptosuccinic acid were significantly inferior to similar measurements with the other agents in differentiating abnormal from normal function. The 2-hr uptake of [99mTc]glucoheptonate and [111In]lysozyme proved of no value in this differentiation. The late renal retention of [99mTc]dimercaptosuccinic acid well separated the cisplatin from control rats, but the greatest difference was observed by the 2-hr uptakes of [131I]hippuran and DTPA.
McAfee
J G
JG
Department of Radiology, SUNY Health Science Center, Syracuse 13210.
Subramanian
G
G
Thomas
F D
FD
Hellwig
B
B
Roskopf
M
M
D000818:Animals; D002945:Cisplatin / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D007205:Indium Radioisotopes / Q000493:pharmacokinetics; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007668:Kidney / Q000000981:diagnostic imaging* / Q000378:metabolism; D007684:Kidney Tubules / Q000187:drug effects*; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium / Q000493:pharmacokinetics; D013997:Time Factors; D014018:Tissue Distribution
D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D013667:Technetium; D002945:Cisplatin