Efficacy of long-acting oxytetracycline alone or in combination with streptomycin for treatment of Brucella ovis infection of rams.
Twenty-four rams inoculated with Brucella ovis by conjunctival and preputial routes were treated with a long-acting oxytetracycline alone or in combination with dihydrostreptomycin sulfate. The combined treatment eliminated Brucella ovis from 11 of 12 (91.6%) treated rams. Only 4 of 12 (33.3%) rams treated with oxytetracycline alone were bacteriologically negative. Neither treatment resolved clinical epididymitis in 2 rams affected before treatment. Many rams had pathologic lesions in the epididymis and ampullae, which limited the efficacy of antibiotic treatment.
Marín
C M
CM
Departamento de Producción Animal, SIA-DGA, Zaragoza, Spain.
Jiménez de Bagués
M P
MP
Barberán
M
M
Blasco
J M
JM
D000818:Animals; D002002:Brucella / Q000302:isolation & purification; D002006:Brucellosis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D008297:Male; D010118:Oxytetracycline / Q000627:therapeutic use*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000382:microbiology; D013307:Streptomycin / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D010118:Oxytetracycline; D013307:Streptomycin