title: [Preventive role of pirenzepine in gastric damage during cytostatic therapy. A controlled randomized double-blind study with placebo].
abstract: Steroids and cytostatic drugs have an undoubtedly damaging action on the gastroduodenal mucosa. The action of pirenzepine was compared with that of the placebo in preventing the gastroduodenal lesions brought on by antiblastic therapy. Sixty patients were separated into two random group under double blind conditions and received 100 mg/die/os of pirenzepine or equivalent placebo for a continuous period of 12 weeks. Antiblastic drugs were administered at the same time. Final endoscopic control and symptomatological findings showed a statistically significant different in favour of the pirenzepine-treated group as early as the 6th week of treatment. No side-effects attributable to pirenzepine were reported.
authors.forename: A
authors.initials: A
authors.lastname: Contu
authors.forename: G
authors.initials: G
authors.lastname: Marenco
authors.forename: P
authors.initials: P
authors.lastname: Pani
authors.forename: M
authors.initials: M
authors.lastname: Meloni
authors.forename: A
authors.initials: A
authors.lastname: Deriu
authors.forename: S
authors.initials: S
authors.lastname: Ortu
authors.forename: N
authors.initials: N
authors.lastname: Olmeo
authors.forename: G M
authors.initials: GM
authors.lastname: Schintu
authors.forename: S
authors.initials: S
authors.lastname: Daniotti
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010890:Pirenzepine / Q000627:therapeutic use*; D010919:Placebos; D016032:Randomized Controlled Trials as Topic; D013272:Stomach Diseases / Q000139:chemically induced* / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents; D010919:Placebos; D010890:Pirenzepine
vernacular_title: Ruolo preventivo della pirenzepina nel danno gastrico in corso di terapia citostatica. Studio in doppio cieco randomizzato controllato con placebo.