title: Inhibitors of rat renin and their use in experimental hypertension.
abstract: Hydroxy-ethylene dipeptide analogues (Leu[CH(OH)-CH2]Leu and Leu[CH(OH)-CH2]Val) of human substrate peptides are potent in vitro inhibitors of rat renin with IC50 values as low as 0.8 nmol/l. When given to renal hypertensive rats they lower blood pressure and suppress both plasma renin and angiotensin II. There was a divergence between the rapid rebound of renin and blood pressure which remained suppressed.
authors.affiliation: MRC Blood Pressure Unit, Western Infirmary, Glasgow, UK.
authors.forename: E C
authors.initials: EC
authors.lastname: Beattie
authors.forename: J J
authors.initials: JJ
authors.lastname: Morton
authors.forename: B J
authors.initials: BJ
authors.lastname: Leckie
authors.forename: J
authors.initials: J
authors.lastname: Sueiras-Diaz
authors.forename: D M
authors.initials: DM
authors.lastname: Jones
authors.forename: M
authors.initials: M
authors.lastname: Szelke
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004353:Drug Evaluation, Preclinical; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D009842:Oligopeptides / Q000627:therapeutic use*; D051381:Rats; D012083:Renin / Q000097:blood; D013997:Time Factors; D000092502:Renin Inhibitors
chemical_list: D009842:Oligopeptides; D012083:Renin; D000092502:Renin Inhibitors; C027509:renin inhibitory peptide