[The relationship of disorders of glucose tolerance in patients with chronic hepatitis and liver cirrhosis to the severity of the pathological process].
Altogether 155 patients with different clinical types of liver lesions were examined: 73 with chronic persistent hepatitis (CPH), 39 with chronic active hepatitis (CAH), and 43 with liver cirrhosis (LC). The patients with chronic liver diseases demonstrated hyperinsulinemia and a decrease in glucose tolerance, a frequency and degree of this decrease growing with the severity of a pathological process. It is postulated taking experiments with partial hepatectomy of rats by way of example that intolerance to glucose and hyperinsulinemia is caused by partial loss of glycogen synthetic function by the liver resulting from a decrease in the number of functionally active cell elements. Experience with 8 LC patients with secondary diabetes mellitus has shown that the addition of the latter is connected with the reduction of secretory capacity of pancreatic beta-cells and with the development of relative insulin insufficiency.
Abdurakhmanova
A M
AM
Rakhimov
N R
NR
Kosovskiĭ
M I
MI
D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002096:C-Peptide / Q000097:blood; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D005767:Gastrointestinal Diseases / Q000097:blood; D005951:Glucose Tolerance Test; D006498:Hepatectomy; D006521:Hepatitis, Chronic / Q000097:blood*; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000209:etiology; D007328:Insulin / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D051381:Rats
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin
Zavisimost' narusheniĭ tolerantnosti k gliukoze u bol'nykh khronicheskimi gepatitami i tsirrozom pecheni ot tiazhesti patologicheskogo protsessa.