title: Degradation of trimethoprim.
abstract: Trimethoprim undergoes thermally and photochemically catalyzed hydrolysis or oxidation to give rise to at least five products. The structures of these compounds were determined by physical methods and it was found that the resonance of C-5 in the 13C NMR spectrum is indicative of the substitution pattern of the resultant amino hydroxy pyrimidines.
authors.affiliation: Department of Pharmaceutical Chemistry, Potchefstroom University for Christian Higher Education, South Africa.
authors.forename: J J
authors.initials: JJ
authors.lastname: Bergh
authors.forename: J C
authors.initials: JC
authors.lastname: Breytenbach
authors.forename: P L
authors.initials: PL
authors.lastname: Wessels
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010777:Photochemistry; D014295:Trimethoprim / Q000032:analysis*
chemical_list: D014295:Trimethoprim