Topical tretinoin and photoaged skin.
Topical tretinoin has been proposed for the treatment of photoaged skin in recent years. In both open and double-blind trials, it has been successful in reversing some of the histologically and clinically apparent changes of photoaging. Many patients will experience a dermatitis due to retinoids during therapy, but are usually able to tolerate the treatment. Although clinical improvement may be modest, most patients are pleased with the result. We have found that optimal improvement is achieved by using tretinoin 0.1 percent cream to the limit of tolerance. By carefully instructing the patient on the application of the medication, the occurrence of initial dermatitis with therapy, and the type of improvement to expect, compliance with and tolerance of tretinoin therapy are greatly enhanced.
Goldfarb
M T
MT
Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109-0314.
Ellis
C N
CN
Weiss
J S
JS
Voorhees
J J
JJ
D000287:Administration, Topical; D000375:Aging; D000818:Animals; D006801:Humans; D051379:Mice; D008812:Mice, Hairless; D010787:Photosensitivity Disorders / Q000188:drug therapy*; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*
D014212:Tretinoin