The history of corticosteroids.
The development from the discovery of the structure of cholesterol, the precursor of all steroids, to the first application of a topically effective steroid in 1952 took about 20 years. Thereafter the development of more potent topically effective steroids accelerated and the third generation of potent steroids with a topical activity of about 10 to 20 times that of hydrocortisone was already available about 10 years later. Today the newly developed non-fluorinated non-symmetric 16 alpha, 17 alpha-acetal derivate budesonide could perhaps be considered as the sixth generation.
Murray
J R
JR
Blackmore Partners, Shaftesbury, UK.
D000305:Adrenal Cortex Hormones / Q000266:history* / Q000627:therapeutic use; D002621:Chemistry; D002784:Cholesterol / Q000266:history; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans
D000305:Adrenal Cortex Hormones; D002784:Cholesterol