Hematological effects in dogs after irradiation of the lower part of the body with a single myeloablative dose.
The lower body of dogs, containing approximately 30% of the total bone marrow, was exposed to 300 kV X-rays with a single myeloablative dose of 11.7 Gy, whereas the upper body was shielded by a lead box. The results of the present study are discussed in connection with recently published results obtained after irradiation of the upper body (UBI), containing approximately 70% of the total bone marrow mass. The main findings are as follows: (1) the nadir in the blood concentration of thrombocytes, lymphocytes, and granulocytes strongly depends on the volume of irradiated bone marrow; (2) apart from some quantitative differences, the time-related pattern of changes in the concentration of granulocyte/macrophage progenitor cells (GM-CFC) in irradiated and shielded bone marrow sites is very similar after irradiation of the lower part of the body (LBI) and UBI, i.e. is apparently independent of the relative amount of damaged bone marrow at volumes applied in the present models; (3) the concentration of GM-CFC in the blood after LBI shows a transient increase during the first phase of most rapid bone marrow GM-CFC regeneration, i.e. between day 7 and day 23; the magnitude of this transient increase obviously depends on the fraction of irradiated bone marrow.
Baltschukat
K
K
Institute of Occupational and Social Medicine, University of Ulm, F.R.G.
Fliedner
T M
TM
Nothdurft
W
W
D000818:Animals; D001772:Blood Cell Count; D001792:Blood Platelets / Q000528:radiation effects; D001853:Bone Marrow / Q000473:pathology / Q000528:radiation effects*; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D006098:Granulocytes / Q000378:metabolism; D008214:Lymphocytes / Q000528:radiation effects; D008264:Macrophages / Q000378:metabolism; D009504:Neutrophils / Q000528:radiation effects; D011835:Radiation Protection