[The diagnostic value of serum PABA determination in pancreatic disease and in relation to anticholinergic medication].
PABA-serum and urine-concentration were studied in patients with normal, pathologic and pharmacologically inhibited pancreatic function. Secretin-pancreozymine test was selected as reference method. In patients with normal pancreas function and volunteers, PABA-serum-concentration was characterized by a rapid increase during the first 1 1/2 hours. A maximum increase of 32.42 +/- 10.04 mumol/l was reached after 90 minutes. In patients with exocrine pancrease insufficiency, difference to the control group was greatest after 30, 60, 90, and 120 min. Pharmacologic inhibition of the exocrine pancreas using pirenzepine also resulted in a significantly reduced PABA-serum-concentration after 30, 60 and 90 min. In correspondence to the delayed and smaller serum PABA increase, urine-PABA-concentrations were also diminished. Our results indicate that the optimal interval to differentiate between normal and impaired pancreas function with use of serum PABA determination is at 90 min after test begin.
von Kleist
D
D
Abteilung für Gastroenterologie, Universitätsklinikums Rudolf Virchow der Freien Universität Berlin.
Rössler
W
W
Janisch
H D
HD
Hampel
K E
KE
D010129:4-Aminobenzoic Acid / Q000493:pharmacokinetics*; D000328:Adult; D002766:Cholecystokinin; D004305:Dose-Response Relationship, Drug; D010188:Exocrine Pancreatic Insufficiency / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010186:Pancreatic Function Tests / Q000379:methods*; D010890:Pirenzepine / Q000494:pharmacology*; D016032:Randomized Controlled Trials as Topic; D011899:Ranitidine / Q000494:pharmacology*; D012633:Secretin
D012633:Secretin; D010890:Pirenzepine; D011899:Ranitidine; D002766:Cholecystokinin; D010129:4-Aminobenzoic Acid
Untersuchungen zum diagnostischen Wert der Serum-PABA-Bestimmung bei Pankreaserkrankung und unter Anticholinerger Medikation.