Soluble extracts from larval Ostertagia ostertagi modulating immune function.
BALB/c mice were immunized with Ostertagia ostertagi antigens and keyhole limpet hemocyanin (KLH) or sheep erythrocytes (SR) for evaluation of antibody production by enzyme linked immunosorbent assay (ELISA) or modified Jerne plaque assay. One semi-purified larval antigen caused both decreased anti-KLH serum antibody levels and fewer anti-SR IgM-secreting B cells. This antigen was shown to depress lymphocyte blastogenesis to Concanavalin A when added to cultured BALB/c splenic lymphocytes.
Cross
D A
DA
Klesius
P H
PH
D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis*; D000947:Antigens, Helminth / Q000276:immunology*; D007814:Larva / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010028:Ostertagia / Q000276:immunology*
D000909:Antibodies, Helminth; D000947:Antigens, Helminth