title: Immunocytochemical studies of astrocytes following injury to the cerebral cortex of the rat.
abstract: The morphological change of cerebral cortex astrocytes from protoplasmic to glial fibrillary acidic protein (GFAP)-containing cells is induced by injury. Protoplasmic astrocytes that contain no detectable amount of GFAP become filled with GFAP and their processes extend to form the glial scar around the wound. It is hypothesized that this transformation is induced by cAMP and neurotransmitters released from damaged neuronal cells. A similar mechanism may be present in other brain regions following injury or disease.
authors.affiliation: Department of Anatomy and Cell Biology, Faculty of Medicine, University of Alberta, Edmonton, Canada.
authors.forename: D N
authors.initials: DN
authors.lastname: Singh
authors.forename: T C
authors.initials: TC
authors.lastname: Mathew
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D002540:Cerebral Cortex / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D002921:Cicatrix / Q000378:metabolism / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D009457:Neuroglia / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005904:Glial Fibrillary Acidic Protein