Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus.
A group of rats was trained to escape low-intensity shock in a shuttle-box test, while another group of yoked controls could not escape but was exposed to the same amount and regime of shock. After 1 week of training, long-term potentiation (LTP) was measured in vitro in hippocampal slices. Exposure to uncontrollable shock massively impaired LTP relative to exposure to the same amount and regime of controllable shock. These results provide evidence that controllability modulates plasticity at the cellular-neuronal level.
Shors
T J
TJ
Department of Psychology, University of Southern California, Los Angeles 90089.
Seib
T B
TB
Levine
S
S
Thompson
R F
RF
D000818:Animals; D001362:Avoidance Learning; D003345:Corticosterone / Q000097:blood; D004597:Electroshock; D004924:Escape Reaction; D006624:Hippocampus / Q000502:physiology*; D007858:Learning / Q000502:physiology; D008297:Male; D008568:Memory / Q000502:physiology; D009473:Neuronal Plasticity; D051381:Rats; D013315:Stress, Psychological / Q000503:physiopathology
D003345:Corticosterone