Factors affecting the response of lung clearance systems to acid aerosols: role of exposure concentration, exposure time, and relative acidity.
The ability of the lungs to clear deposited material is essential for maintenance of lung homeostasis. Acid aerosols have been shown to alter the efficiency of this process. This paper assesses the role of acid aerosol exposure concentration (C), exposure time (T), and relative acidity in producing changes in clearance from both the tracheobronchial tree and respiratory region of the lungs of rabbits. The response was found to be due to total exposure, i.e., some combination form of C x T, and was also related to relative acidity.
Schlesinger
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RB
Institute of Environmental Medicine, New York University Medical Center, NY 10016.
D015258:Acid Rain / Q000633:toxicity*; D000336:Aerosols; D000393:Air Pollutants / Q000633:toxicity*; D000645:Ammonium Sulfate / Q000633:toxicity; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006863:Hydrogen-Ion Concentration; D008168:Lung / Q000187:drug effects*; D008297:Male; D009079:Mucociliary Clearance / Q000187:drug effects*; D011817:Rabbits; D012307:Risk Factors; D013464:Sulfuric Acids / Q000633:toxicity
D015258:Acid Rain; D000336:Aerosols; D000393:Air Pollutants; D013464:Sulfuric Acids; C034007:ammonium bisulfate; C033158:sulfuric acid; D000645:Ammonium Sulfate