[The effect of denervation on ligandin levels and glutathione S-transferase activity in the rat liver].
The authors studied the effect of liver denervation (transection of the hepatic branch of the vagus nerve and/or both splanchnic nerves) on the content of the marker of highly-differentiated hepatocytes--ligandin and the activity of glutathione S-transferase (GT) in rat liver homogenate. The immunodiffusion method demonstrated a decrease in the ligandin level by 21-22% as compared to the value in intact rats 2 weeks after the operation. GT activity was reduced in rats with denervation of the liver but remained unchanged in sham-operated on animals. The results are evidence of diminished biochemical specialization of the tissue of a denervated liver and confirm the role of the peripheral nervous system, the afferent link in particular, in its regulation.
Spiridonov
V K
VK
Nikiforov
A F
AF
Kaledin
V I
VI
D000818:Animals; D003714:Denervation; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology* / Q000294:innervation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005982:Glutathione Transferase
Vliianie denervatsii na soderzhanie ligandina i aktivnost' gliutation S-transferazy v pecheni krys.