title: Chromosome aberrations in peripheral blood lymphocytes of welders and characterization of their exposure by biological samples analysis.
abstract: Chromosomal aberrations in cultured lymphocytes obtained from 55 welders and 55 matched controls were analyzed. Depending on the welding techniques and the nature of the consumables and metals welded, three separate groups of welders were examined. Chromium, nickel, and manganese levels in serum and urine were measured to assess the exposure to welding fumes. A statistically significant increase of chromosomal aberrations was found in one of the three analyzed groups of welders. This group used the semi-automatic metal active gas welding process with cored wire containing nickel for welding mild steel. These welders had significantly higher concentrations of serum and urine manganese and, unlike the other welders, significantly elevated concentrations of nickel, both in serum and urine. However, no significant correlations between nickel or manganese levels and the frequency of chromosomal aberrations were found. There was a significant correlation between the length of welding employment of these welders and the frequency of chromosomal breaks, although there was no significant correlation between age and the frequency of chromosomal aberrations. The other two groups of welders, for which the analyses of biologic fluids proved chromium and manganese exposure, had no statistically significant higher frequency of chromosomal aberrations. One of these groups used the manual metal arc welding process with coated electrodes for welding mainly mild steel and the other group used the tungsten inert gas welding process for welding stainless steel. A significant correlation between the daily amount of cigarettes smoked and the frequency of chromosomal breakages, in controls as in welders, was observed. The present data indicate that certain welding processes may generate fumes that seem to have a clastogenic activity.
authors.affiliation: Department of Experimental Industrial Toxicology, National Institute for Research and Safety (INRS), Vandoeuvre-les-Nancy, France.
authors.forename: Z
authors.initials: Z
authors.lastname: Elias
authors.forename: J M
authors.initials: JM
authors.lastname: Mur
authors.forename: F
authors.initials: F
authors.lastname: Pierre
authors.forename: S
authors.initials: S
authors.lastname: Gilgenkrantz
authors.forename: O
authors.initials: O
authors.lastname: Schneider
authors.forename: F
authors.initials: F
authors.lastname: Baruthio
authors.forename: M C
authors.initials: MC
authors.lastname: Danière
authors.forename: J M
authors.initials: JM
authors.lastname: Fontana
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D002478:Cells, Cultured; D002857:Chromium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D002869:Chromosome Aberrations; D004784:Environmental Monitoring; D005069:Evaluation Studies as Topic; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000648:ultrastructure*; D008297:Male; D008345:Manganese / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008677:Metaphase; D008875:Middle Aged; D009532:Nickel / Q000097:blood / Q000378:metabolism* / Q000652:urine; D012307:Risk Factors; D012854:Sister Chromatid Exchange; D012907:Smoking / Q000097:blood / Q000378:metabolism / Q000652:urine; D013997:Time Factors; D014896:Welding
chemical_list: D000395:Air Pollutants, Occupational; D002857:Chromium; D008345:Manganese; D009532:Nickel