title: Effect of histamine on chemotaxis and phagocytosis of human alveolar macrophages and blood monocytes.
abstract: We studied in vitro the effect of histamine on the chemotactic and phagocytic abilities of human blood monocytes and alveolar macrophages. The chemotactic response to activated autologous serum, leukotriene B4 or N-formyl-methionine-L-phenylalanine was similar for macrophages and monocytes. Incubation of monocytes with histamine in picomolar concentrations caused a significant chemotactic inhibition (about 25%). This effect was antagonized by cimetidine but not by promethazine. Histamine did not have an effect on alveolar macrophages chemotaxis or phagocytosis. Thus, histamine, in minute concentrations, exerts, in vitro, a partial inhibitory effect on monocyte chemotaxis through activation of H2-type receptors.
authors.affiliation: Division of Respiratory Medicine, CHU Sart-Tilman, State University of Liège, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Radermecker
authors.forename: T
authors.initials: T
authors.lastname: Bury
authors.forename: P
authors.initials: P
authors.lastname: Saint-Remy
mesh_terms: D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008264:Macrophages / Q000502:physiology*; D009000:Monocytes / Q000502:physiology*; D010587:Phagocytosis / Q000187:drug effects*; D011650:Pulmonary Alveoli / Q000166:cytology
chemical_list: D006632:Histamine