title: HPA axis disturbance in obsessive-compulsive disorder.
abstract: Twenty nondepressed outpatients with DSM-III obsessive-compulsive disorder entered a 10-week placebo-controlled study of clomipramine and underwent a 1-mg dexamethasone suppression test (DST) at baseline; 11 had a repeat DST at the end of treatment: Nonsuppression was rare. When compared to 82 previously described outpatients with panic disorder studied in a similar fashion, OCD patients had postdexamethasone cortisol values that were substantially lower and more stable over time. Results within the OCD group closely resembled those from a group of never-ill controls.
authors.affiliation: Department of Psychiatry, University of Iowa, Iowa City 52242.
authors.forename: W H
authors.initials: WH
authors.lastname: Coryell
authors.forename: D W
authors.initials: DW
authors.lastname: Black
authors.forename: M W
authors.initials: MW
authors.lastname: Kelly
authors.forename: R
authors.initials: R
authors.lastname: Noyes
mesh_terms: D002986:Clinical Trials as Topic; D002997:Clomipramine / Q000627:therapeutic use; D003907:Dexamethasone / Q000493:pharmacokinetics; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D010913:Pituitary-Adrenal System / Q000503:physiopathology*
chemical_list: D003907:Dexamethasone; D002997:Clomipramine; D006854:Hydrocortisone