Enhanced conception by stored porcine sperm stimulated with chloroquine.
The effect of chloroquine stimulation on the motility of porcine sperm stored for 6 h and on the subsequent conception rate was assessed. There was a drastic decline in sperm motility after 6 h storage at 4 degrees and 25 degrees C, and a concomitant depression in their conception rate. However, chloroquine stimulation restored these functions towards normal, especially in sperm stored at 25 degrees C. These observations, coupled with the stability of the litter size, regardless of treatment, suggest that chloroquine can be used in an artificial insemination programme involving the utilization of semen several hours after collection and some distance away from the source of the ejaculate.
Egbunike
G N
GN
Department of Animal Science, University of Ibadan, Nigeria.
D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D005260:Female; D007315:Insemination, Artificial / Q000662:veterinary*; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal; D012662:Semen Preservation / Q000662:veterinary*; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D013552:Swine / Q000502:physiology*
D002738:Chloroquine