title: [Monitoring and treatment of toxoplasmosis in the pregnant woman, fetus and newborn].
abstract: A protocol of monitoring and treatment in toxoplasmosis is suggested by the authors. During pregnancy, the administration of spiramycine at a 9 m UI daily dose remains the basic preventive treatment when a seroconversion occurs after a 4 week post-conception period. In the fetus, the antenatal diagnosis is made by ultrasound started on the 18th week after conception and repeated every 4 weeks, amniocentesis and eventually umbilical cord puncture associated with a pyrimethamine-sulfamide drug treatment in case of positive diagnosis. A therapeutic pregnancy termination is considered when lesions have been detected by ultrasound. In the newborn (neonatal or post-natal period), the diagnosis is made by transfontanel ultrasonography, ocular fundi and spinal fluid examination, detection of specific IgM antibodies in cord blood and the evolution and importance of serum antibodies response requiring a drug treatment during 15-18 months with spiramycine and pyrimethamine + sulfadoxine (Fansidar).
authors.affiliation: Laboratoire de parasitologie, Faculté de médecine et de pharmacie, Lyon, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Garin
authors.forename: M
authors.initials: M
authors.lastname: Mojon
authors.forename: M A
authors.initials: MA
authors.lastname: Piens
authors.forename: I
authors.initials: I
authors.lastname: Chevalier-Nuttall
mesh_terms: D000649:Amniocentesis; D002675:Child, Preschool; D005260:Female; D005323:Fetal Monitoring; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008991:Monitoring, Physiologic; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011292:Premedication; D011296:Prenatal Diagnosis; D012173:Retinitis / Q000209:etiology; D015572:Spiramycin / Q000627:therapeutic use*; D014125:Toxoplasmosis, Congenital / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D014463:Ultrasonography
chemical_list: D015572:Spiramycin
vernacular_title: Surveillance et traitement de la toxoplasmose chez la femme enceinte, le foetus et le nouveau-né.