Enhanced clearance of vancomycin by hemodialysis in a child.
Clearance of vancomycin by hemodialysis has previously been reported to be negligible. We describe a child undergoing chronic hemodialysis using a hollow fiber dialyzer with cellulose acetate membrane. When the patient was treated with intravenous vancomycin for staphylococcal bacteremia, the serum vancomycin half-life was found to decrease by more than 90% during each course of hemodialysis. We conclude that, contrary to prevailing opinion, vancomycin can be rapidly cleared by hemodialysis in the small pediatric patient, and that the dosage should be adjusted accordingly.
Schoumacher
R
R
Department of Pediatrics, University of Virginia, Medical Center, Charlottesville 22908.
Chevalier
R L
RL
Gomez
R A
RA
Rogol
A D
AD
Cummings
R
R
Spyker
D A
DA
D002648:Child; D005260:Female; D006207:Half-Life; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy; D006435:Renal Dialysis; D014640:Vancomycin / Q000493:pharmacokinetics*
D014640:Vancomycin