[Study of general principles of humoral immune response in viral infection by sample analysis of the properties of specific immunoglobulins].
Humoral immunity in murine experimental influenza was specified using experimental mathematical modelling intended for further systemic analysis of dynamics of immunological processes. The methodology of the proposed approach was based on the choice of affinity as an indicator of the function of specific antibodies, and on the concept of discrete functional structure of the immune system. The data were obtained by calculating affinity and antibody heterogeneity indices and by evaluating the distribution of functions by affinity. The successions of active antibody subpopulations with affinities varying in the course of infection and the presence in the plasma of protein fractions capable of low-affinity binding with influenza virus in non-infected animals were demonstrated. The relationship between the detected plasma protein populations and corresponding antibody-producing cells was confirmed. The mathematical modelling results were verified by physicochemical and immunochemical methods. The mechanisms by which the observed phenomena may be realized were considered from the viewpoint of the current theory of immunity.
Voĭtsekhovskiĭ
B L
BL
Meringova
L F
LF
Dukhin
A I
AI
Agafonova
I I
II
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis / Q000276:immunology*; D000915:Antibody Affinity / Q000276:immunology; D000918:Antibody Specificity / Q000276:immunology; D000921:Antibody-Producing Cells / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D001666:Binding Sites, Antibody; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis / Q000276:immunology*; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000473:pathology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007074:Immunoglobulin G
Issledovanie obshchikh zakonomernosteĭ gumora'lnogo immunnogo otveta pri virusnoĭ infektsii posredstvom diskretnogo analiza svoĭstv spetsificheskikh immunoglobulinov.