Deficiency of the corpus callosum: incomplete penetrance and substrain differentiation in BALB/c mice.
In a foundation population of BALB/c mice used to establish a colony at Waterloo in 1977, about 11% of adults showed either total absence or gross deficiency of the corpus callosum. Comparisons between parents and offspring, between progenies of different males, and between 13 separate lines established by full-sib inbreeding showed that variation in the adult corpus callosum reflected a genuine incomplete penetrance in a genetically uniform population. However, after seven generations of inbreeding, a spontaneous change occurred in one line (BALB/cWah 1), resulting in more than 50% of adults with deficient corpus callosum, among which about 20% have complete absence of callosal axons traversing the hemispheres.
Wahlsten
D
D
Dept. of Psychology, Univ. of Waterloo, Ontario, Canada.
D061085:Agenesis of Corpus Callosum; D000818:Animals; D003337:Corpus Callosum / Q000033:anatomy & histology; D003433:Crosses, Genetic; D005260:Female; D005838:Genotype; D007178:Inbreeding; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics*; D008957:Models, Genetic; D015233:Models, Statistical