[Stimulation of immunogenesis by neurotensin, pentagastrin and thymopentin and ways of its realization].
In experiments on mice and in vitro the influence of neurotensin pentagastrin and thymopentin on the immune response, the phagocytosis of staphylococcus aureus by polymorphoneutrophil leucocytes and enzymatic activity of these cells by NBT-test were investigated. It was shown that neurotensin and thymopentin increase enzymatic and phagocytic function of polymorphoneutrophil leucocytes. Pentagastrin, as well as thymopentin stimulates the immune response, enzymatic but not phagocytic function of polymorphoneutrophil leucocytes. Immunostimulating effect of the studied peptides was realized by facility differentiation of mouse bone marrow cells into T-lymphocytes and by the interaction of the peptides with T-cells.
Belokrylov
G A
GA
Molchanova
I V
IV
Popova
O Ia
OIa
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009496:Neurotensin / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology*; D010418:Pentagastrin / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D010587:Phagocytosis; D013211:Staphylococcus aureus; D016305:Thymopentin; D013946:Thymopoietins / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; D009496:Neurotensin; D010418:Pentagastrin; D016305:Thymopentin
Stimuliatsiia immunogeneza neĭrotenzinom, pentagastrinom, timopentinom i puti ee realizatsii.