Lack of effect of paracetamol on the pharmacokinetics of chloramphenicol.
The effect of oral paracetamol (1 g) on the pharmacokinetics of oral chloramphenicol (500 mg) was examined in five adult male Zimbabwean patients with normal hepatic and renal function. No significant alteration of half-life, area under the concentration-time curve or peak concentration of chloramphenicol was observed. The previously reported, potentially serious interaction between chloramphenicol and paracetamol administered intravenously was not observed with the more commonly used oral preparations.
Stein
C M
CM
Department of Clinical Pharmacology, Godfrey Huggins School of Medicine, University of Zimbabwe, Avondale, Harare.
Thornhill
D P
DP
Neill
P
P
Nyazema
N Z
NZ
D000082:Acetaminophen / Q000008:administration & dosage / Q000494:pharmacology*; D000284:Administration, Oral; D000328:Adult; D002701:Chloramphenicol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged
D000082:Acetaminophen; D002701:Chloramphenicol