title: [The SSPE model: suggestions for an explication of viral persistence].
abstract: The detection of a latent viral flora intrinsic to the central nervous system (CNS) raises the problem to know if some neuropathogenic strains have the property of initiating persistent infections or if the persistence is the result of the immune response particularities at the CNS level. A review is done of the pathogenic explanations of virus persistence in SSPE, followed by the discussion about two pathogenic alternatives issues from the author's studies: the antigenic "drift" hypothesis and the one of the defective interfering particles preferential synthesis.
authors.affiliation: Institut de Virologie Stefan S. Nicolau, Bucarest, Roumanie.
authors.forename: C
authors.initials: C
authors.lastname: Cernescu
mesh_terms: D000940:Antigenic Variation / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D003673:Defective Viruses / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D005814:Genes, Viral; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007111:Immunity, Cellular / Q000276:immunology; D013190:SSPE Virus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D013344:Subacute Sclerosing Panencephalitis / Q000209:etiology / Q000235:genetics / Q000276:immunology / Q000382:microbiology*
chemical_list: D000956:Antigens, Viral
vernacular_title: Le modèle de la PESS: suggestions pour une explication de la persistance du virus.