Hyperthermia-induced modulation of killing and mutation by UV and N-methyl-N'-nitro-N-nitrosoguanidine in V79 cells.
Hyperthermic exposures of V79 cells did not affect the killing by UV light, whereas it enhanced MNNG-induced killing. Such hyperthermic exposure increased the mutation induction (resistance to 6-thioguanine) by both UV and MNNG. The timing of heat exposure, before or after the treatments, had no effect on the result in cases of cytotoxicity and mutagenesis.
Banerjee
S
S
Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Calcutta, India.
Bhaumik
G
G
Bhattacharjee
S B
SB
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004260:DNA Repair; D006979:Hyperthermia, Induced; D008769:Methylnitronitrosoguanidine / Q000378:metabolism / Q000633:toxicity*; D009153:Mutagens / Q000378:metabolism; D013997:Time Factors; D014466:Ultraviolet Rays
D009153:Mutagens; D008769:Methylnitronitrosoguanidine