Treatment of t(4;11) acute leukemia with aggressive multiagent chemotherapy. Preliminary results.
Acute leukemia patients with a 4;11 translocation have had a poor prognosis in the past, averaging 9 months survival from diagnosis. Three patients from The Children's Hospital of Denver were reported in 1982--all died. This report describes five additional patients who fared better. Aggressive treatment during induction and maintenance with intensive alternating non-cross-resistant chemotherapeutic agents may have contributed to the improved survival.
Hays
T
T
Children's Hospital, Denver, CO 80218.
Morse
H G
HG
Crouse
V L
VL
Odom
L F
LF
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D005819:Genetic Markers; D006801:Humans; D007223:Infant; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics; D011379:Prognosis; D014178:Translocation, Genetic
D005819:Genetic Markers