The influence of bromocriptine on the ultrastructure of cultured T47D (human breast cancer) cells.
Following a previous ultrastructural study of untreated T47D human breast cancer cells, we studied the influence of bromocriptine on the same cell line with the electron microscope. Our results suggest that bromocriptine exerts a direct effect on the morphology of T47D cells, which after treatment were better preserved. Some morphological evidence was noted hinting that colchicine and bromocriptine may have some similar properties. It is possible that the T47D cell line is biologically responsive to bromocriptine and therefore it is a potentially useful model for studies on the mechanism of action of bromocriptine on the morphological level in human breast cancer.
Polyzonis
M
M
Symeonidis Research Center, Theagenion Cancer Institute, Thessaloniki, Greece.
Kortsaris
A
A
Stravoravdi
P
P
D001943:Breast Neoplasms / Q000648:ultrastructure*; D001971:Bromocriptine / Q000494:pharmacology*; D002460:Cell Line; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000648:ultrastructure*
D001971:Bromocriptine