[Effect of nifedipine on effective renal plasma flow, plasma renin activity and serum aldosterone, noradrenaline and adrenaline levels in healthy persons and in patients with primary moderate arterial hypertension].
Blood pressure, plasma renin activity, and serum aldosterone, adrenaline and noradrenaline were investigated in healthy individuals and patients with the primary moderate hypertension following a single oral dose of 10 mg nifedipine. It was found that the drug is hypotensive in both healthy individuals and hypertensive patients. It does not affect the effective plasma flow throughout the kidneys as well as serum aldosterone and adrenaline whereas serum noradrenaline and plasma renin activity are increased.
Halawa
B
B
Mazurek
W
W
D000328:Adult; D000450:Aldosterone / Q000097:blood; D004837:Epinephrine / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D009638:Norepinephrine / Q000097:blood*; D012016:Reference Values; D012079:Renal Circulation / Q000187:drug effects* / Q000502:physiology; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects* / Q000502:physiology
D000450:Aldosterone; D012083:Renin; D009543:Nifedipine; D009638:Norepinephrine; D004837:Epinephrine
Wpływ nifedypiny na efektywny przepływ osocza przez nerki, aktywność reninowa osocza, stezenie aldosteronu, noradrenaliny i adrenaliny w surowicy osób zdrowych i chorych na nadciśnienie tetnicze pierwotne umiarkowane.