title: Superficial spreading melanoma with a nodular area: antigenic phenotype of the radial and vertical growth areas.
abstract: We investigated antigenic features associated with different tumor progression steps in primary melanoma, interpreted as different patterns of growth (radial and vertical) in the same and in different lesions. Thirty-eight primary melanomas were examined: 18 superficial spreading malanomas, 13 superficial spreading melanomas with a nodular area and 7 nodular melanomas. 225.28,763.74, CL.203, VF19LL209, VF19LL217, Q5.13, W6.32 and anti-HLA-DR monoclonal antibodies were used. Phenotypic differences between radial and vertical growth areas were observed but no statistical significance could be found.
authors.affiliation: Clinica Dermatologica II dell'Università degli Studi di Frienze, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Brogelli
authors.forename: S
authors.initials: S
authors.lastname: Moretti
authors.forename: B
authors.initials: B
authors.lastname: Giannotti
mesh_terms: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D008545:Melanoma / Q000276:immunology* / Q000473:pathology; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000032:analysis; D010641:Phenotype
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D006684:HLA-DR Antigens; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins