Successful treatment of progressive disseminated histoplasmosis with amphotericin B methyl ester.
Amphotericin B methyl ester (AME) has been used to treat fungal infections, most often those caused by Coccidioides immitis. We describe the only patient with disseminated histoplasmosis who has been treated with AME. After having had alarming reactions to amphotericin B, the patient was treated and cured with AME without adverse drug effect or later relapse.
Neihart
R E
RE
Division of Infectious Diseases, University of Kansas Medical Center, College of Health Sciences and Hospital, Kansas City 66103.
Hinthorn
D R
DR
Hoeprich
P D
PD
Liu
C
C
D000368:Aged; D000666:Amphotericin B / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D004361:Drug Tolerance; D006660:Histoplasmosis / Q000188:drug therapy*; D006801:Humans; D008297:Male
D000935:Antifungal Agents; C017501:methylamphotericin B; D000666:Amphotericin B