Codon preference and primary sequence structure in protein-coding regions.
The stochastic complexity of a data base of 365 protein-coding regions is analysed. When the primary sequence is modeled as a spatially homogeneous Markov source, the fit to observed codon preference is very poor. The situation improves substantially when a non-homogeneous model is used. Some implications for the estimation of species phylogeny and substitution rates are discussed.
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D000596:Amino Acids / Q000032:analysis; D001483:Base Sequence; D003062:Codon; D008433:Mathematics; D008957:Models, Genetic; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger
D000596:Amino Acids; D003062:Codon; D011506:Proteins; D012333:RNA, Messenger