title: Blood coagulation changes in rats during development of epithelioma.
abstract: Coagulation activity in the blood of rats during the development of Guerin epithelioma was studied. Clotting time, level of fibrinogen and some coagulation factors (II, V, VII + X) in the plasma were determined and thromboelastographic studies were performed. Two periods of blood hypercoagulability were observed in the process of epithelioma development. The first a short-term period, was noticed during the first days following the implantation of the neoplastic tissue. The second took place during the intensive growth of the primary tumor and metastases.
authors.affiliation: Medical Academy, Institute of Environmental Research and Bioanalysis, Department of Biochemistry, Lódź, Poland.
authors.forename: R
authors.initials: R
authors.lastname: Tomasiuk
authors.forename: H
authors.initials: H
authors.lastname: Gawlowska
authors.forename: B
authors.initials: B
authors.lastname: Sawicka
authors.forename: W
authors.initials: W
authors.lastname: Mielicki
authors.forename: R
authors.initials: R
authors.lastname: Wierzbicki
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D002277:Carcinoma / Q000097:blood*; D005165:Factor V / Q000032:analysis; D005167:Factor VII / Q000032:analysis; D005170:Factor X / Q000032:analysis; D005260:Female; D011516:Prothrombin / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
chemical_list: D005165:Factor V; D005167:Factor VII; D011516:Prothrombin; D005170:Factor X