Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes.
Naturally occurring compounds belonging to two chemical groups were studied for their capacities to inhibit N-nitrosodiethylamine (NDEA)-induced carcinogenesis in female A/J mice. One group consists of organosulfur compounds found in Allium species, including garlic, onions, leeks, and shallots, and the other, two monoterpenes, i.e., D-limonene and D-carvone. In an initial experiment, in which organosulfur compounds were investigated, diallyl disulfide, allyl mercaptan, and allyl methyl disulfide were found to produce a marked inhibition of NDEA-induced neoplasia of the forestomach when the test compounds were administered p.o. 96 and 48 h prior to NDEA. The most potent was diallyl disulfide which reduced forestomach tumor formation by more than 90%. Pulmonary adenoma formation also was inhibited but to a considerably lesser extent, i.e., about 30%. In three additional experiments, test compounds were given p.o. either 15 min or 1 h prior to NDEA. Under these conditions diallyl disulfide and allyl mercaptan again inhibited forestomach tumor formation substantially, i.e., greater than 75%, and pulmonary adenoma formation marginally, i.e., less than 20%. In these experiments D-limonene and D-carvone were tested and reduced forestomach tumor formation by slightly over 60% and pulmonary adenoma formation by about 35%. The results of these studies provide evidence of an increasing diversity of naturally occurring compounds having the capacity to inhibit nitrosamine carcinogenesis.
Wattenberg
L W
LW
Department of Laboratory Medicine, University of Minnesota, Minneapolis 55455.
Sparnins
V L
VL
Barany
G
G
D000490:Allium; D000498:Allyl Compounds; D000818:Animals; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D004052:Diethylnitrosamine; D004220:Disulfides / Q000494:pharmacology; D005260:Female; D000077222:Limonene; D051379:Mice; D039821:Monoterpenes; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013440:Sulfides / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology*
D000498:Allyl Compounds; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D004220:Disulfides; D039821:Monoterpenes; D013440:Sulfides; D013729:Terpenes; D004052:Diethylnitrosamine; C028009:diallyl disulfide; C038491:allyl sulfide; C006923:carvone; D000077222:Limonene