A suppressive mechanism counteracts the production of anti-idiotype antibody.
BALB/c mice were repeatedly, at two-week intervals, immunized with monoclonal antibody against hepatitis B surface antigen and their sera were titrated for anti-idiotype antibody. The highest titres appeared after 1-4 immunizations. Further immunizations led to fast disappearance of the anti-idiotype antibody. These data suggest that anti-idiotype antibody production is a rather complicated process in which some suppressive mechanism is involved.
Korec
E
E
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha.
Korcová
J
J
Hlozánek
I
I
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis* / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D007108:Immune Tolerance; D007114:Immunization; D007124:Immunoenzyme Techniques; D051379:Mice; D008807:Mice, Inbred BALB C
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D006514:Hepatitis B Surface Antigens