Protective effect of a synthetic peptide comprising the complete preS2 region of the hepatitis B virus surface protein.
A peptide was synthesized containing the entire 55 amino acid residue sequence of the hepatitis B virus (HBV) surface antigen preS2 region (ad subtype). The unconjugated peptide was inoculated into four chimpanzees. Following multiple injections, all of the animals developed specific antipeptide antibodies that reacted with intact surface antigen particles bearing the preS2 moiety. All four peptide-inoculated animals were found to be protected from infection after intravenous challenge with live HBV of either the ad or ay subtypes.
Emini
E A
EA
Department of Virus and Cell Biology, Merck, Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486.
Larson
V
V
Eichberg
J
J
Conard
P
P
Garsky
V M
VM
Lee
D R
DR
Ellis
R W
RW
Miller
W J
WJ
Anderson
C A
CA
Gerety
R J
RJ
D000818:Animals; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000096:biosynthesis; D006514:Hepatitis B Surface Antigens / Q000138:chemical synthesis / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D002679:Pan troglodytes; D011498:Protein Precursors / Q000138:chemical synthesis / Q000276:immunology*; D014612:Vaccines / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D011498:Protein Precursors; D014612:Vaccines; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines; C050807:presurface protein 2, hepatitis B surface antigen