Peripheral nerve regeneration in quail-chick spinal cord chimeras treated with oral ciclosporin.
Regeneration of chimeric wing nerves in 2 quail-chick spinal cord chimeras is reported. The large DNA-containing quail nucleolar marker could not be distinguished in flattened cells, and in particular, in perineurial cell nuclei of chimeric nerves. With oral ciclosporin treatment, rejection of graft-derived nervous system tissues was acute and florid in one chimera, but followed a chronic, remitting course in the other.
Uzman
B G
BG
VA Medical Center, Memphis, Tenn.
Suzuki
K
K
Villegas
G M
GM
D000284:Administration, Oral; D000818:Animals; D002642:Chick Embryo; D002678:Chimera; D003524:Cyclosporins / Q000008:administration & dosage / Q000494:pharmacology*; D006084:Graft Rejection / Q000187:drug effects; D008854:Microscopy, Electron; D009416:Nerve Regeneration / Q000187:drug effects*; D010525:Peripheral Nerves / Q000254:growth & development*; D011784:Quail; D013116:Spinal Cord / Q000637:transplantation*
D003524:Cyclosporins