title: Vasoactive intestinal polypeptide stimulates cholecystokinin secretion in perfused rat duodenum.
abstract: We examined the effect of vasoactive intestinal polypeptide (VIP) on cholecystokinin (CCK) secretion from the isolated perfused rat duodenum. VIP stimulated CCK secretion mono-phasically in a concentration-dependent manner in concentrations ranging from 10(-9) to 10(-7) M, and 10(-7) M of VIP led to an increment of 82 +/- 25.8 fmole/3 min. The stimulatory effect of VIP on CCK was not inhibited by 10(-5) M atropine. These results suggest that VIP may directly stimulate CCK secretion from the duodenum and work as a non-cholinergic, peptidergic neurotransmitter.
authors.affiliation: National Kyushu Cancer Center, Fukuoka, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Funakoshi
authors.forename: I
authors.initials: I
authors.lastname: Nakano
authors.forename: K
authors.initials: K
authors.lastname: Miyazaki
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000378:metabolism*; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
chemical_list: D014660:Vasoactive Intestinal Peptide; D002766:Cholecystokinin