Release of acetylcholinesterase from the guinea-pig substantia nigra during peripheral nerve stimulation.
A soluble form of acetylcholinesterase is released from the substantia nigra in both a spontaneous and drug-induced fashion. The aim of this study was to see whether this phenomenon was also sensitive to a non-pharmacological event. During electrical stimulation of the intact sciatic nerve, there was an increase in the activity of acetylcholinesterase, measured in perfusates of the guinea-pig substantia nigra in vivo. This increase was not due to spontaneous fluctuations in acetylcholinesterase release, plasma contamination, tissue damage or release of acetylcholinesterase from a non-specific site. The possible pathways mediating this phenomenon are discussed.
Taylor
S J
SJ
University Laboratory of Pharmacology, Oxford, U.K.
Greenfield
S A
SA
D000110:Acetylcholinesterase / Q000378:metabolism*; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D006168:Guinea Pigs; D012584:Sciatic Nerve / Q000502:physiology*; D013378:Substantia Nigra / Q000201:enzymology* / Q000502:physiology; D013997:Time Factors
D000110:Acetylcholinesterase