A linkage group with FRA16B (the fragile site at 16q22.1).
Polymorphic DNA markers located in bands 16q13, 16q21 and 16q22 were examined for recombination with FRA16B, the fragile site at 16q22.100. A tight linkage cluster D16S10-FRA16B-D16S4-HP was established. There were no recombinants (theta = 0.0, z = 8.3) between D16S10 and D16S4, which flank FRA16B. The markers D16S10 and D16S4 are in close proximity on the genetic map and delineate a small chromosomal segment, which contains the distamycin A-inducible fragile site.
Mulley
J C
JC
Department of Histopathology, Adelaide Children's Hospital, Australia.
Hyland
V J
VJ
Fratini
A
A
Bates
L J
LJ
Gedeon
A K
AK
Sutherland
G R
GR
D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D010375:Pedigree
D005819:Genetic Markers