title: Genetic studies on pancreatic proteinase in Japanese quail.
abstract: A genetic variation was found in pancreatic proteinase of Japanese quail. In eight bands of proteinase isozymes, the variation of band 5 (presence or absence) was detected among quails. Band 5 was identified as a chymotrypsin. The presence and absence of band 5 are controlled by a pair of allelic genes (Prt-5A and Prt-5a) on an autosomal locus, and gene Prt-5A, causing expression of band 5, is dominant to gene Prt-5a, a null allele for band 5. Zymograms of proteinases and their zymogens were also compared; no variation of chymotrypsinogen; corresponding to chymotrypsin Prt 5 were detected. It is suggested that the Prt-5 variant of chymotrypsin may be formed during activation of chymotrypsinogen.
authors.affiliation: Department of Animal Science, Faculty of Agriculture, Kagoshima University, Japan.
authors.forename: D X
authors.initials: DX
authors.lastname: Hou
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: S
authors.initials: S
authors.lastname: Okamoto
authors.forename: T
authors.initials: T
authors.lastname: Hashiguchi
mesh_terms: D000483:Alleles; D000818:Animals; D002918:Chymotrypsin / Q000235:genetics*; D002919:Chymotrypsinogen / Q000235:genetics; D003370:Coturnix / Q000235:genetics*; D010450:Endopeptidases / Q000235:genetics*; D004792:Enzyme Precursors / Q000235:genetics; D005787:Gene Frequency; D005796:Genes; D014644:Genetic Variation; D007527:Isoenzymes / Q000235:genetics; D010179:Pancreas / Q000201:enzymology*; D010641:Phenotype; D011784:Quail / Q000235:genetics*; D014357:Trypsin / Q000235:genetics
chemical_list: D004792:Enzyme Precursors; D007527:Isoenzymes; D002919:Chymotrypsinogen; D010450:Endopeptidases; D002918:Chymotrypsin; D014357:Trypsin