title: [Midazolam for premedication of infants. A comparison of the effect between oral and rectal administration].
abstract: Midazolam (M) has been successfully used in oral and rectal premedication of children of one to six years of age. The following study was designed to investigate the efficacy of both methods when used as premedication "on demand". 60 children (1-6 years) were randomly assigned to 0.3 mg/kg bw M orally and 0.5 mg/kg bw M rectally. Psychological, behavioural and physiological parameters were measured at special time intervals and special stressful events (separation from the mother or father, induction of anaesthesia). Rectally premedicated children were found to be better prepared concerning psychological and behavioural parameters. This can be due to the dosage as well as the faster absorption of M. In the postoperative period orally premedicated children experienced significantly more nausea and vomiting. This might be due to the preparation with saccharin, peppermint oil and ethanol. - In "premedication on demand" rectal Midazolam must be preferred to orally administered Midazolam in the preparation mentioned above.
authors.affiliation: Klinik für Anästhesiologie der Med. Fak. der RWTH Aachen.
authors.forename: W
authors.initials: W
authors.lastname: Tolksdorf
authors.forename: D
authors.initials: D
authors.lastname: Bremerich
authors.forename: U
authors.initials: U
authors.lastname: Nordmeyer
mesh_terms: D000284:Administration, Oral; D000285:Administration, Rectal; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008874:Midazolam / Q000008:administration & dosage*; D011229:Preanesthetic Medication; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D016037:Single-Blind Method
chemical_list: D008874:Midazolam
vernacular_title: Midazolam zur Prämedikation von Kleinkindern. Ein Wirkungsvergleich zwischen der oralen und rektalen Applikation.