[Immunocorrective treatment of idiopathic thrombocytopenic purpura by plasmapheresis].
Patients with idiopathic thrombocytopenic purpura (ITP) tolerated well plasmapheresis. In no cases hemorrhage intensification was observed. An immediate clinical effect was recorded in all patients that correlated with the immunological parameters improvement in most of them. The platelet count significantly rose only in one patient immediately after the plasmapheresis course. The follow-up of the patients during 11-20 months has enabled revealing not only immediate clinical but also late hematological effect of plasmapheresis, that was manifest in a delayed rise of the platelet levels in most patients, and abolished resistance to glucocorticoids in one of them. It has been concluded that plasmapheresis produces immunocorrecting effect and could be used for the treatment of ITP patients.
Kovaleva
L G
LG
Reshetnikova
M E
ME
Kalinin
N N
NN
Petrova
V I
VI
Iakovleva
O N
ON
D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000209:etiology / Q000276:immunology / Q000628:therapy*
D001323:Autoantibodies
Immunokorrigiruiushchee lechenie idiopaticheskoĭ trombotsitopenicheskoĭ purpury putem plazmafereza.