Lateralization of dementia of depression in stroke patients.
In a group of stroke patients with left-hemisphere lesions, those with major depression performed significantly below nondepressed patients on four of nine cognitive domains examined with a neuropsychological test battery. Among patients with right-hemisphere stroke, those with major depression did not perform below nondepressed patients on any of the nine cognitive domains. The differential effect of depression on cognitive performance between left- and right-hemisphere lesion groups could not be accounted for by demographic variables, neurological symptoms, lesion location, or lesion size. Poststroke major depression appeared to produce a decline in cognitive performance or dementia of depression that depended on the laterality of the lesion.
Bolla-Wilson
K
K
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore 21224.
Robinson
R G
RG
Starkstein
S E
SE
Boston
J
J
Price
T R
TR
D001921:Brain / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000150:complications*; D003704:Dementia / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D003866:Depressive Disorder / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D014057:Tomography, X-Ray Computed