title: Regulation of the mitochondrial multienzyme complexes in complex metabolic systems.
abstract: During the past two decades, I and the members of my laboratory have enjoyed very much contributing to the body of knowledge concerning the alpha-keto acid dehydrogenase complexes. We would hope that some of our work has allowed those interested in this area a perception as to how these interesting enzyme complexes are regulated in intact metabolic systems. And last, but certainly not least, I have treasured both my professional relationship and my personal friendship with Lester Reed. His work and his presence in this field of inquiry serve as a gold standard for all of us.
authors.affiliation: Department of Biochemistry, University of Texas Health Science Center, San Antonio 78284-7760.
authors.forename: M S
authors.initials: MS
authors.lastname: Olson
mesh_terms: D042942:3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); D050960:Aminomethyltransferase; D000818:Animals; D006706:Homeostasis; D019877:Hydroxymethyl and Formyl Transferases; D007658:Ketone Oxidoreductases / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology*; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000378:metabolism*; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D014166:Transferases / Q000378:metabolism
chemical_list: D009097:Multienzyme Complexes; D011768:Pyruvate Dehydrogenase Complex; D007658:Ketone Oxidoreductases; D042942:3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); D014166:Transferases; D019877:Hydroxymethyl and Formyl Transferases; D050960:Aminomethyltransferase