Adenoviruses as vectors for the transfer of genetic information and for the construction of new type vaccines.
At present many types of corpuscular nondefective, conditional-defective and helper-dependent expressing adenoviral vectors are available which can be used in constructing gene-engineered live or inactivated viral vaccines. In particular, promising results have been obtained with live recombinant human adenoviruses expressing the S antigen of hepatitis B virus, capsid protein of rotaviruses and gB protein of herpes virus. These recombinants are proper candidates for testing as corresponding vaccine strains, a good alternative to well-known recombinant vaccine virus.
Tikchonenko
T I
TI
Institute of Agricultural Biotechnology, Academy of Agricultural Sciences, Moscow, USSR.
D000256:Adenoviridae / Q000235:genetics* / Q000276:immunology*; D000818:Animals; D005822:Genetic Vectors; D006801:Humans; D014614:Vaccines, Synthetic / Q000276:immunology; D014765:Viral Vaccines
D014614:Vaccines, Synthetic; D014765:Viral Vaccines