Inhibitors of rat renin and their use in experimental hypertension.
Hydroxy-ethylene dipeptide analogues (Leu[CH(OH)-CH2]Leu and Leu[CH(OH)-CH2]Val) of human substrate peptides are potent in vitro inhibitors of rat renin with IC50 values as low as 0.8 nmol/l. When given to renal hypertensive rats they lower blood pressure and suppress both plasma renin and angiotensin II. There was a divergence between the rapid rebound of renin and blood pressure which remained suppressed.
Beattie
E C
EC
MRC Blood Pressure Unit, Western Infirmary, Glasgow, UK.
Morton
J J
JJ
Leckie
B J
BJ
Sueiras-Diaz
J
J
Jones
D M
DM
Szelke
M
M
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004353:Drug Evaluation, Preclinical; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D009842:Oligopeptides / Q000627:therapeutic use*; D051381:Rats; D012083:Renin / Q000097:blood; D013997:Time Factors; D000092502:Renin Inhibitors
D009842:Oligopeptides; D012083:Renin; D000092502:Renin Inhibitors; C027509:renin inhibitory peptide