title: In vitro modulation of lymphocyte proliferation by prednisolone and interferon-alpha in patients with HTLV-I-associated myelopathy (HAM).
abstract: One of the hallmarks of human T-lymphotropic virus type I (HTLV-I) infection is the proliferation in vitro of peripheral blood lymphocytes (PBLs) in the absence of growth factors. This phenomenon, the autologous proliferative response (APR), involves spontaneous growth of HTLV-I-infected T-cells and proliferation of T-cells in response to the infected cells. We studied the modulating effect of prednisolone (PSL) and interferon-alpha (IFN) on APR of PBLs obtained from five patients with HTLV-I-associated myelopathy (HAM). APR was significantly inhibited by PSL and IFN suggesting that APR is important in the pathogenesis of HAM.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ijichi
authors.forename: N
authors.initials: N
authors.lastname: Eiraku
authors.forename: M
authors.initials: M
authors.lastname: Osame
authors.forename: S
authors.initials: S
authors.lastname: Izumo
authors.forename: R
authors.initials: R
authors.lastname: Kubota
authors.forename: I
authors.initials: I
authors.lastname: Maruyama
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: S
authors.initials: S
authors.lastname: Sonoda
mesh_terms: D000328:Adult; D000368:Aged; D002455:Cell Division / Q000187:drug effects; D005260:Female; D015490:HTLV-I Infections / Q000150:complications*; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D008214:Lymphocytes / Q000473:pathology*; D008875:Middle Aged; D011239:Prednisolone / Q000494:pharmacology*; D013118:Spinal Cord Diseases / Q000097:blood / Q000209:etiology* / Q000473:pathology
chemical_list: D007370:Interferon Type I; D011239:Prednisolone