title: Pyruvate dehydrogenase activities during the fed-to-starved transition and on re-feeding after acute or prolonged starvation.
abstract: We investigated the temporal relationship between hepatic glycogen depletion and cardiac and hepatic PDH (pyruvate dehydrogenase complex) activities during the acute phase of starvation. There was a striking correlation between the decline in hepatic glycogen and PDH inactivation during the first 10 h of starvation. Re-feeding after 6 h starvation was associated with complete re-activation of PDH in liver and re-activation to approx. 75% of the fed value in heart, whereas in rats previously starved for 24-48 h re-activation was delayed in liver and diminished in heart. The results are discussed with reference to the fate of dietary carbohydrate after re-feeding.
authors.affiliation: Department of Chemical Pathology, London Hospital Medical College, U.K.
authors.forename: M J
authors.initials: MJ
authors.lastname: Holness
authors.forename: M C
authors.initials: MC
authors.lastname: Sugden
mesh_terms: D000818:Animals; D005260:Female; D005502:Food; D008099:Liver / Q000201:enzymology*; D008112:Liver Glycogen / Q000032:analysis / Q000172:deficiency*; D009206:Myocardium / Q000201:enzymology*; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism*; D013997:Time Factors
chemical_list: D008112:Liver Glycogen; D011768:Pyruvate Dehydrogenase Complex