title: Metabolic control and effect on secondary complications of diabetes mellitus by pancreatic transplantation.
abstract: After successful pancreatic transplantation blood glucose can be normalized without exogenous insulin, although oral and intravenous glucose tolerance remains impaired in 10-45% of the patients. There is no significant deterioration of glucose control with time in most patients. Since most recipients of pancreatic grafts have far advanced secondary diabetic lesions and the observation time after grafting is rather short, the effects of pancreatic transplantation on these complications are difficult to interpret. However, the development of diabetic nephropathy can be prevented, skin microcirculation improves significantly, while autonomic and peripheral neuropathy and diabetic retinopathy remain stable or improve slightly in most patients. But these ameliorations may be in part due to elimination of uraemia, since in almost all patients combined pancreas/kidney transplantations were performed. It is concluded that pancreas grafting probably has to be performed much earlier in the course of diabetes, although the improvement in the quality of life is striking even in the end-stage diabetics studied so far.
authors.forename: R
authors.initials: R
authors.lastname: Landgraf
authors.forename: J
authors.initials: J
authors.lastname: Nusser
authors.forename: R
authors.initials: R
authors.lastname: Scheuer
authors.forename: A
authors.initials: A
authors.lastname: Fiedler
authors.forename: A
authors.initials: A
authors.lastname: Scheider
authors.forename: E
authors.initials: E
authors.lastname: Meyer-Schwickerath
authors.forename: W
authors.initials: W
authors.lastname: Müller-Felber
authors.forename: W D
authors.initials: WD
authors.lastname: Illner
authors.forename: D
authors.initials: D
authors.lastname: Abendroth
authors.forename: W
authors.initials: W
authors.lastname: Land
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000601:surgery*; D003928:Diabetic Nephropathies / Q000517:prevention & control; D003929:Diabetic Neuropathies / Q000517:prevention & control; D003930:Diabetic Retinopathy / Q000517:prevention & control; D006801:Humans; D016035:Pancreas Transplantation; D011788:Quality of Life
chemical_list: D001786:Blood Glucose