[Presumed toxoplasmic chorioretinitis: comparative study of treatment with pyrimethamine and sulfadiazine or clindamycin].
A prospective, randomized study was conducted in 29 patients with presumed toxoplasmic retinochoroiditis to compare the efficacy of oral pyrimethamine and sulfadiazine (P + S) with subconjunctival injections of clindamycin. There was no difference in the mean visual acuity in both groups after treatment; the mean healing time was similar in the two treatment groups, 1.80 months with clindamycin and 1.88 month with P + S. However subjective improvement was obtained earlier with clindamycin. After 14 months' follow up, recurrences of ocular toxoplasmosis developed in both groups, 21% with clindamycin and 36% with P + S, respectively (NS). Other than the discomfort due to topical treatment, clindamycin did not produce any side-effects, which did happened after oral P + S. Subconjunctival injections of clindamycin provide an interesting alternative in the choice of an antitoxoplasmic ocular therapy.
Colin
J
J
Service d'Ophtalmologie, CHR Brest.
Harie
J C
JC
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D002825:Chorioretinitis / Q000188:drug therapy*; D002981:Clindamycin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011739:Pyrimethamine / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D013411:Sulfadiazine / Q000627:therapeutic use*; D014126:Toxoplasmosis, Ocular / Q000188:drug therapy*
D013411:Sulfadiazine; D002981:Clindamycin; D011739:Pyrimethamine
Choriorétinites présumées toxoplasmiques: etude comparative des traitements par pyriméthamine et sulfadiazine ou clindamycine.