A multisubstrate adduct inhibitor of a purine biosynthetic enzyme with a picomolar dissociation constant.
Inglese
J
J
Chemistry Department, Pennsylvania State University, University Park 16802.
Blatchly
R A
RA
Benkovic
S J
SJ
D000217:Acyltransferases / Q000037:antagonists & inhibitors*; D000970:Antineoplastic Agents / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D019877:Hydroxymethyl and Formyl Transferases; D008968:Molecular Conformation; D051026:Phosphoribosylglycinamide Formyltransferase; D011687:Purines / Q000096:biosynthesis*; D012265:Ribonucleotides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011687:Purines; D012265:Ribonucleotides; C014978:glycineamide ribonucleotide; C059395:ThioGar; D019877:Hydroxymethyl and Formyl Transferases; D051026:Phosphoribosylglycinamide Formyltransferase; D000217:Acyltransferases