Lipid peroxidation in human diseases: evidence of red cell oxidative stress after circulatory shock.
Erythrocytes obtained from human patients with circulatory shock of different aetiology consistently showed a strong increase in lipid peroxidation-derived aldehydes in comparison with red cells of normal adults. The highly toxic compound 4-hydroxynonenal has been recovered exclusively in the erythrocytes of the patients.
Poli
G
G
Department of Experimental Medicine and Oncology of the University, Torino, Italy.
Biasi
F
F
Chiarpotto
E
E
Dianzani
M U
MU
De Luca
A
A
Esterbauer
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000447:Aldehydes / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010084:Oxidation-Reduction; D012769:Shock / Q000097:blood*; D012770:Shock, Cardiogenic / Q000097:blood; D013053:Spectrophotometry
D000447:Aldehydes; D008315:Malondialdehyde; C027576:4-hydroxy-2-nonenal