Myotonic dystrophy is closely linked to the gene for muscle-type creatine kinase (CKMM).
We have studied genetic linkage between the gene for creatine kinase muscle type (CKMM) and the gene for myotonic dystrophy (DM). In a panel of 65 myotonic dystrophy families from Canada and the Netherlands, a maximum lod score (Zmax) of 22.8 at a recombination frequency (theta) of 0.03 was obtained. Tight linkage was also demonstrated for CKMM and the gene for apolipoprotein C2 (ApoC2). This establishes CKMM as a useful marker for myotonic dystrophy.
Brunner
H G
HG
Department of Human Genetics, University of Nijmegen, Radboud Hospital, The Netherlands.
Korneluk
R G
RG
Coerwinkel-Driessen
M
M
MacKenzie
A
A
Smeets
H
H
Lambermon
H M
HM
van Oost
B A
BA
Wieringa
B
B
Ropers
H H
HH
D053304:Apolipoprotein C-II; D001056:Apolipoproteins C / Q000235:genetics; D002888:Chromosomes, Human, Pair 19; D003402:Creatine Kinase / Q000235:genetics*; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007527:Isoenzymes; D009223:Myotonic Dystrophy / Q000235:genetics*; D011995:Recombination, Genetic
D053304:Apolipoprotein C-II; D001056:Apolipoproteins C; D005819:Genetic Markers; D007527:Isoenzymes; D003402:Creatine Kinase