Antihepatotoxic principles of Solanum capsicastrum.
Two new steroidal alkaloids named capsimine and isocapsicastrine were isolated from the root bark of Solanum capsicastrum. Their structures were elucidated by chemical degradation and spectral data as (22R, 25R)-22,26-epiminocholest-5-ene-3 beta, 16 alpha-diol and (22S,25S)-O(3)-beta-D-glucopyranosyl-22,26-epiminocholest-5-ene-3 beta-16 alpha-diol, respectively. Capsicastrine, capsicastrine acetate, isoteinemine acetate, and etioline exhibited strong activity against liver damage induced by CCl4.
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D000818:Animals; D008107:Liver Diseases / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D012991:Solanaceous Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*
D012991:Solanaceous Alkaloids; C059671:capsimine; C059672:isocapsicastrine