Isolation and structure of corazonin, a cardioactive peptide from the American cockroach.
Corazonin, a new cardioaccelerating peptide, has been isolated from the corpora cardiaca of the American cockroach, Periplaneta americana, and its structure determined to be Glp-Thr-Phe-Gln-Tyr-Ser-Arg-Gly-Trp-Thr-Asn-amide. The peptide stimulated heart beat at concentrations as low as 0.2 nM, which makes it the most potent insect cardioactive neuropeptide.
Veenstra
J A
JA
Department of Biological Organic Chemistry, Centro de Investigación y Desarrollo, CSIC, Barcelona, Spain.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003058:Cockroaches; D006321:Heart / Q000187:drug effects*; D019476:Insect Proteins; D008968:Molecular Conformation; D009479:Neuropeptides / Q000302:isolation & purification* / Q000494:pharmacology; D010455:Peptides / Q000302:isolation & purification*
D019476:Insect Proteins; D009479:Neuropeptides; D010455:Peptides; C060602:corazonin protein, insect