In vivo antigenic variation of Campylobacter flagellin.
Campylobacter coli VC167 cells producing either antigenic phase 1 (P1) or phase 2 (P2) flagellins (as determined by characteristic protein and DNA patterns) were used to infect rabbits by the removable intestinal tie-adult rabbit diarrhea (RITARD) procedure. Rabbits infected with P2 cells shed predominantly P2 cells throughout the infection; in rabbits infected with P1 cells, a transition of fecal isolates from P1 to P2 was observed.
Logan
S M
SM
Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada.
Guerry
P
P
Rollins
D M
DM
Burr
D H
DH
Trust
T J
TJ
D000818:Animals; D000940:Antigenic Variation; D000942:Antigens, Bacterial / Q000235:genetics / Q000302:isolation & purification*; D001426:Bacterial Proteins / Q000302:isolation & purification*; D002167:Campylobacter / Q000276:immunology*; D004269:DNA, Bacterial / Q000302:isolation & purification; D003967:Diarrhea / Q000382:microbiology; D005408:Flagellin / Q000235:genetics / Q000302:isolation & purification*; D011817:Rabbits
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D005408:Flagellin