beta-eudesmol (a main component of Atractylodes lancea)-induced potentiation of depolarizing neuromuscular blockade in diaphragm muscles of normal and diabetic mice.
Potentiating effects of beta-eudesmol on neuromuscular blockade were investigated in phrenic nerve-diaphragm muscles of normal and alloxan-diabetic mice. Pretreatment with beta-eudesmol potentiated the blocking effects of succinylcholine to a greater extent in diabetic muscles than in normal ones. This effect was saturated after 30-min pretreatment in normal muscles. Further potentiation was observed after 60-min pretreatment in diabetic muscles. These results suggest that beta-eudesmol modifies the sensitivity of diabetic mice to depolarizing blockers so that they have a higher susceptibility to these compounds.
Muroi
M
M
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Tanaka
K
K
Kimura
I
I
Kimura
M
M
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008297:Male; D051379:Mice; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010791:Phrenic Nerve / Q000187:drug effects; D012132:Respiratory Muscles / Q000187:drug effects*; D045787:Sesquiterpenes, Eudesmane; D013390:Succinylcholine / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D009466:Neuromuscular Blocking Agents; D045787:Sesquiterpenes, Eudesmane; D013729:Terpenes; C051082:beta-eudesmol; D013390:Succinylcholine