title: Mitochondrial and microsomal lipid peroxidation in rat liver after acute acetaldehyde and ethanol intoxication.
abstract: The effects of acetaldehyde and ethanol treatments on hepatic lipid peroxidation are compared in rats after the administration of toxically corresponding doses. Wistar rats were given a single dose of acetaldehyde (0.5 g/kg) or ethanol (5 g/kg) intraperitoneally. The animals were killed 1/2, 1, 2, 4, 6, 9, 12 and 24 h after treatments. The results indicate that acetaldehyde, like ethanol, stimulates hepatic lipid peroxidation and also selectively affects the hepatic mitochondria.
authors.affiliation: Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Uysal
authors.forename: G
authors.initials: G
authors.lastname: Ozdemirler
authors.forename: G
authors.initials: G
authors.lastname: Kutalp
authors.forename: H
authors.initials: H
authors.lastname: Oz
mesh_terms: D000079:Acetaldehyde / Q000633:toxicity*; D000435:Alcoholic Intoxication / Q000378:metabolism*; D000818:Animals; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008315:Malondialdehyde; D000079:Acetaldehyde