title: Effects of chronic hyperglycemia on electrocortical activity states in unanesthetized fetal lambs.
abstract: Electrocortical activity (ECoG), tracheal pressure and nuchal muscle activity were recorded in utero in 8 chronically hyperglycemic and 10 control unanesthetized fetal lambs to investigate the effects of chronic hyperglycemia on fetal electrocortical activity states. The chronically hyperglycemic state, induced by alloxan administered to the ewes, existed for at least 40 days prior to the experiments. The mean duration of episodes of high voltage (HV) ECoG was significantly increased in the hyperglycemic group (mean +/- SD: 21.8 +/- 9.2 min) compared with the control group (14.8 +/- 3.3 min), but the incidence of low voltage (LV) ECoG was not different between the groups. ECoG power spectra were not different between the groups. During LV ECoG, the proportions of time with neck movements were significantly less in the hyperglycemic than in the control group. No difference in percentages of time with long neck muscle activity was seen during the HV state in both groups. The incidence of breathing movements was equal in both groups, during HV as well as LV ECoG. No differences in breathing interval were observed.
authors.affiliation: Institute of Obstetrics and Gynecology, Catholic University, Nijmegen, The Netherlands.
authors.forename: J P
authors.initials: JP
authors.lastname: Lips
authors.forename: H W
authors.initials: HW
authors.lastname: Jongsma
authors.forename: J J
authors.initials: JJ
authors.lastname: Menssen
authors.forename: A J
authors.initials: AJ
authors.lastname: Crevels
authors.forename: T K
authors.initials: TK
authors.lastname: Eskes
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D004576:Electromyography; D005071:Evoked Potentials; D005260:Female; D005324:Fetal Movement; D006943:Hyperglycemia / Q000503:physiopathology*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D012756:Sheep
chemical_list: D001786:Blood Glucose