title: [Response of the immature brain to changes in the internal and external environment. (30 years' neuro-ontology research at the Physiology Institute)].
abstract: The authors summarize some original results obtained in long-term neuroontogenetic research. Substrate variability of immature CNS tissue, its capacity of ketone bodies utilization are described and basic developmental changes in the composition of amino acids, fatty acids and key enzymes in brain are established. Analysis of immature CNS adaptability and plasticity, especially in relation to hypoxic load is presented. On the contrary the results indicating very low resistance of newborn mammal to insufficient nutrition and its far-reaching consequences concerning regulations and functional capacities are presented.
authors.forename: S
authors.initials: S
authors.lastname: Trojan
authors.forename: J
authors.initials: J
authors.lastname: Mourek
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D005311:Fetal Hypoxia / Q000378:metabolism / Q000503:physiopathology; D002534:Hypoxia, Brain / Q000378:metabolism*; D009473:Neuronal Plasticity; D011247:Pregnancy
vernacular_title: Odpovĕd nezralého mozku na zmĕny vnitrního a zevního prostredí.(30 let neuroontogenetického výzkumu ve Fyziologickém ústavu).