Age-related digoxin-verapamil interactions in the adult rat.
We have previously described a method for inducing atrial ectopic tachycardia (AET) in the anesthetized adult rat using digoxin, 30 mg/kg s.c. In this study, we used this model to study digoxin-verapamil interactions in young and older male rats and have found age-related differences in their responses to digoxin alone and to digoxin-verapamil interactions as well. Overall, 90% of the animals of both groups combined that developed AET, developed a ventricular proarrhythmic response to verapamil. Thus, this model might broaden the pre-clinical evaluation of anti-arrhythmic agents and predict which drugs are most likely to have a proarrhythmic effect.
Weinhouse
E
E
Medical College of Wisconsin, Department of Pediatrics, Milwaukee.
Kaplanski
J
J
Jarenwattananon
M
M
Nudel
D B
DB
D000375:Aging / Q000502:physiology*; D000818:Animals; D004077:Digoxin / Q000494:pharmacology*; D004347:Drug Interactions; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013610:Tachycardia / Q000139:chemically induced; D014700:Verapamil / Q000494:pharmacology*
D004077:Digoxin; D014700:Verapamil