[Change in the influenza virus upon multiplication in the presence of high concentrations of remantadine].
It was established that classical fowl plague virus Rostock (H7N1) propagated in culture to which 10-25 micrograms/ml of remantadine had been added differed from the original FPV and its remantadine-resistant variant by markedly reduced infectious and hemagglutinating activity and, to a lesser extent, neuraminidase activity, lower amounts of M protein and hemagglutinin, incomplete cleavage of hemagglutinin, and significant loss of spikes on the virion surface.
Karako
N I
NI
Boreko
E I
EI
Kirillov
V A
VA
Votiakov
V I
VI
D000218:Adamantane / Q000031:analogs & derivatives*; D004352:Drug Resistance, Microbial; D004591:Electrophoresis, Polyacrylamide Gel; D006387:Hemagglutination, Viral / Q000187:drug effects; D006389:Hemagglutinins, Viral / Q000032:analysis; D009980:Influenza A virus / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D012299:Rimantadine / Q000494:pharmacology*; D014763:Viral Matrix Proteins / Q000032:analysis; D014764:Viral Proteins / Q000032:analysis; D014779:Virus Replication / Q000187:drug effects
D006389:Hemagglutinins, Viral; D014763:Viral Matrix Proteins; D014764:Viral Proteins; D012299:Rimantadine; D000218:Adamantane
Izmenenie virusa grippa pri razmnozhenii v prisutstvii vysokikh kontsentratsiĭ remantadine.