A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids.
The anti-asthmatic activity of AA-2414 [(+/-)-7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptano ic acid] has been studied in vivo and in vitro. Experimental allergic asthma was inhibited by orally administered AA-2414 in a dose-dependent manner. AA-2414, 0.08-1.25 mg/kg (p.o.), inhibited the bronchconstriction in guinea pigs induced by a prostaglandin endoperoxide analogue (U-46619), leukotriene D4 (LTD4), and platelet activating factor (PAF) with a long duration of action. The compound did not inhibit histamine-induced bronchoconstriction. AA-2414 reduced the induction of pulmonary inflation caused by LTD4 aerosol inhalation. AA-2414 competitively inhibited the contractile response to U-46619 in guinea pig tracheal and parenchymal strips and dog saphenous vein strips with pA2 values of 7.69, 8.29 and 6.79, respectively. Furthermore, the contractile responses of guinea pig tracheal strip to PGD2, 9 alpha, 11 beta-PGF2 and PGF2 alpha were inhibited with pA2 values of 7.20, 7.79 and 5.71, respectively. These results suggest that AA-2414, a quinone derivative, is a novel, potent and orally active antagonist of a variety of spasmogenic prostanoids.
Ashida
Y
Y
Biology Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan.
Matsumoto
T
T
Kuriki
H
H
Shiraishi
M
M
Kato
K
K
Terao
S
S
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy*; D016227:Benzoquinones; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006538:Heptanoic Acids; D006633:Histamine Antagonists / Q000494:pharmacology; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D015230:Prostaglandin D2 / Q000037:antagonists & inhibitors; D011450:Prostaglandin Endoperoxides, Synthetic / Q000037:antagonists & inhibitors; D011809:Quinones / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013189:SRS-A / Q000037:antagonists & inhibitors; D014132:Trachea / Q000503:physiopathology
D016227:Benzoquinones; D006538:Heptanoic Acids; D006633:Histamine Antagonists; D010972:Platelet Activating Factor; D011450:Prostaglandin Endoperoxides, Synthetic; D011809:Quinones; D013189:SRS-A; C060230:seratrodast; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D015230:Prostaglandin D2