title: Increased reactivity to histamine in the coronary vascular system of the guinea-pig after endotoxin.
abstract: Histamine produced a dose-dependent increase in heart rate, myocardial contractility and coronary flow in the isolated guinea-pig heart using a modified Langendorff procedure. Intraperitoneal treatment of the guinea pigs with E. coli endotoxin, 4 days prior to the experiment, enhanced the positive chronotropic and flow-increasing effect of histamine. The increased response to histamine appeared to be H1-receptor mediated, the positive chronotropic response is attributed to H2-receptors. These results indicate that bacterial endotoxin increases the reactivity of the coronary vascular system of the guinea-pig to histamine.
authors.affiliation: Department of Veterinary Pharmacology, University of Utrecht, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: van Heuven-Nolsen
authors.forename: G A
authors.initials: GA
authors.lastname: Ten Have
authors.forename: F P
authors.initials: FP
authors.lastname: Nijkamp
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D004731:Endotoxins / Q000633:toxicity*; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011968:Receptors, Histamine / Q000502:physiology
chemical_list: D004731:Endotoxins; D011968:Receptors, Histamine; D006632:Histamine