title: [Thrombopenic purpura associated with human immunodeficiency virus infection. Analysis of 24 cases].
abstract: In 24 cases of thrombopenic purpura associated with human immunodeficiency virus infection the clinical, immunological and therapeutic features were evaluated. Thrombopenia resulted in clinical manifestations in 20 patients. Splenomegaly was found in only one fourth of patients. Antiplatelet antibodies were found in 9 patients, and thrombopenia was associated with anemia in 37% of cases and with leukopenia in 21%. Bone marrow examination showed megakaryocyte hyperplasia in two thirds of the patients. The major immunological abnormalities were an inverted helper/suppressor T lymphocytes ratio, a reduction in the number of helper T lymphocytes, polyclonal hypergammaglobulinemia, and increased serum concentrations of circulating immunocomplexes. The different therapeutic modalities, steroids, vincristine, danatrol and plasma exchange, resulted in short responses; only two patients had normal platelet counts. The median follow-up was 14 months; during this time three patients fulfilled the criteria of acquired immunodeficiency syndrome.
authors.forename: E
authors.initials: E
authors.lastname: Aguilar Ligorit
authors.forename: J
authors.initials: J
authors.lastname: Guix García
authors.forename: I
authors.initials: I
authors.lastname: Benet Monforte
authors.forename: I
authors.initials: I
authors.lastname: Marugán de la Concha
authors.forename: V
authors.initials: V
authors.lastname: Escrig Orenga
authors.forename: A
authors.initials: A
authors.lastname: Pascual López
authors.forename: V
authors.initials: V
authors.lastname: Alberola Candel
authors.forename: J
authors.initials: J
authors.lastname: García-Conde Bru
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000175:diagnosis; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010951:Plasma Exchange; D011241:Prednisone / Q000627:therapeutic use; D011696:Purpura, Thrombocytopenic / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D013997:Time Factors; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D011241:Prednisone
vernacular_title: Púrpura trombopénica asociada a infección por virus de la inmunodeficiencia humana. Análisis de 24 casos.