Distribution and metabolism of 1,2,4-trimethylbenzene (pseudocumene) in the rat.
1. Single doses of 1,2,4-trimethylbenzene (124TMB) or 14C-124TMB were administered orally to rats for metabolism and distribution studies. 2. 14C-124TMB was rapidly and widely distributed throughout the body with the highest levels in adipose tissue. No other preferential uptake of 14C-124TMB by any of the organs or tissues examined was evident. 3. Tissue levels declined rapidly within 24 h after dosage, with more than 99% of the administered radioactivity recovered in the urine during this period. 4. A complex mixture of isomeric trimethylphenols, dimethylbenzyl alcohols, dimethylbenzoic acids and dimethylhippuric acids excreted in the urine accounted for more than 81% of the administered dose. The major metabolites were 3,4-dimethylhippuric acid (30.2% dose), 2,4-dimethylbenzyl alcohol (12.7% dose, primarily as sulphate and glucuronide conjugates) and 2,5-dimethylbenzyl alcohol (11.7% dose, primarily as sulphate and glucuronide conjugates).
Huo
J Z
JZ
School of Pharmacy, University of Tasmania, Australia.
Aldous
S
S
Campbell
K
K
Davies
N
N
D000284:Administration, Oral; D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D001555:Benzene Derivatives / Q000378:metabolism* / Q000493:pharmacokinetics / Q000652:urine; D002250:Carbon Radioisotopes; D008401:Gas Chromatography-Mass Spectrometry; D005965:Glucuronates / Q000652:urine; D005966:Glucuronidase / Q000378:metabolism; D006868:Hydrolysis; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D011919:Rats, Inbred Strains; D013431:Sulfates / Q000652:urine
D001555:Benzene Derivatives; D002250:Carbon Radioisotopes; D005965:Glucuronates; D013431:Sulfates; C010313:pseudocumene; D001192:Arylsulfatases; D005966:Glucuronidase