Cardiovascular reaction pattern during endotoxin or peptidoglycan application in awake sheep.
Peptidoglycans (PG) and lipopolysaccharides (LPS) are cell wall constituents of bacteria. The relative contents vary significantly between gram-negative and gram-positive strains. Since both strains take part in clinical septicemia, we compared hemodynamic and permeability properties in a sheep model with chronic instrumentation and lung lymph drainage. The cardiovascular reaction patterns of PG and LPS were comparable at very different dose levels, with LPS being 10,000-fold more potent. Continuous infusion produced an increase in lung permeability (only with LPS) and cardiac output, as well as fever, to mimic the hyperdynamic situation in early septicemia.
Redl
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H
Ludwig Boltzmann Institute for Experimental Traumatology, Vienna, Austria.
Schlag
G
G
Thurnher
M
M
Traber
L D
LD
Traber
D L
DL
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008168:Lung / Q000098:blood supply; D008196:Lymph / Q000502:physiology; D010100:Oxygen / Q000097:blood; D010457:Peptidoglycan / Q000008:administration & dosage / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000502:physiology; D012756:Sheep; D013929:Thromboxane B2 / Q000097:blood; D014655:Vascular Resistance / Q000187:drug effects
D004731:Endotoxins; D010457:Peptidoglycan; D013929:Thromboxane B2; D010100:Oxygen