Serum selenium concentration, glutathione peroxidase activity and lipid peroxides in a co-twin control study on multiple sclerosis.
Serum selenium concentration, glutathione peroxidase activity and lipid peroxides were determined in patients with multiple sclerosis (MS). The series consisted of 13 same-sexed twin pairs derived from the Finnish Twin Cohort of 15,815 pairs. Fourteen subjects had a definite and 1 a probable MS, and their 11 co-twins showed no evidence of central nervous system disease. No statistical differences were observed, but the 3 patients with active progressive MS had a higher mean level of lipid peroxides than the rest of the patients. We suggest that serum lipid peroxidation may be involved in the activity of MS.
Korpela
H
H
Department of Physiology, University of Oulu, Finland.
Kinnunen
E
E
Juntunen
J
J
Kumpulainen
J
J
Koskenvuo
M
M
D000328:Adult; D000368:Aged; D004200:Diseases in Twins; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000378:metabolism*; D012643:Selenium / Q000097:blood*; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D008054:Lipid Peroxides; D005979:Glutathione Peroxidase; D012643:Selenium