Familial thin basement membrane nephropathy in children with asymptomatic microhematuria.
A review of 130 children with persistent microhematuria showed that the most common abnormality was a form of hereditary nephritis for wich we propose the term 'familial thin basement membrane nephropathy' (FTBMN). This lesion is not as severe as that of Alport's syndrome but carries a guarded prognosis. Family histories, urinalyses and audiograms systematically done on parents and other relatives show that FTBMN may be present in as many as 39% of children with persistent microhematuria and that careful family studies identify children likely to have this lesion.
Gauthier
B
B
Schneider Children's Hospital of Long Island Jewish Medical Center, New Hyde Park, N.Y.
Trachtman
H
H
Frank
R
R
Valderrama
E
E
D000293:Adolescent; D001485:Basement Membrane / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006417:Hematuria / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D009394:Nephritis, Hereditary / Q000235:genetics* / Q000473:pathology; D012189:Retrospective Studies