Superiority of perfusion over bolus administration in cancer chemotherapy: proposition of a compartmental model.
Recent studies indicate that, for cancer chemotherapy, prolongation of drug injection time yields lower toxicity and better efficacy. We propose a compartmental pharmacological model to explain these observations. The model has been simulated on an analog computer. The curves obtained give a credible explanation for the clinical data. The superiority of perfusion over bolus injection may be attributed to plasma peak suppression.
Desoize
B
B
Institut J. Godinot, Reims, France.
Garrett
E R
ER
D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D001682:Biological Availability; D001783:Blood Flow Velocity; D010478:Chemotherapy, Cancer, Regional Perfusion; D003198:Computer Simulation; D006801:Humans; D007277:Injections, Jet; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology
D000970:Antineoplastic Agents