title: Chromosomal characteristics of malignant lymphoma.
abstract: Results of a cytogenetic and morphological study of 60 malignant lymphomas (ML) are presented. The most often observed chromosome abnormalities were rearrangements involving 14q32, 11q13, 11q21-23, 6q15, 6q21, 12p11-12, 17p11-12, and extra chromosomes 18, 3, 21 and 7. Translocations involving 14q32, leading to the appearance of marker 14q+, were noted in 41% of the tumors. Strict correlations between karyotype and morphology of ML were not seen. However, rearrangements of 11q were mostly found in low-grade tumors and markers 6q- in high-grade tumors. The absence of t(14;18), which is regarded to be the most common abnormality in ML, and an unusually high incidence of t(11;14) in our series confirm the uneven geographical distribution of ML with these translocations. Chromosome abnormalities in ML and acute lymphoblastic leukemia are compared.
authors.affiliation: Cytogenetic Laboratory of All-Union Cancer Research Center AMN USSR, Moscow.
authors.forename: E W
authors.initials: EW
authors.lastname: Fleischman
authors.forename: E L
authors.initials: EL
authors.lastname: Prigogina
authors.forename: G W
authors.initials: GW
authors.lastname: Ilynskaya
authors.forename: N A
authors.initials: NA
authors.lastname: Probatova
authors.forename: L N
authors.initials: LN
authors.lastname: Konstantinova
authors.forename: G V
authors.initials: GV
authors.lastname: Kruglova
authors.forename: M A
authors.initials: MA
authors.lastname: Volkova
authors.forename: D S
authors.initials: DS
authors.lastname: Osmanov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D005819:Genetic Markers