Evaluating the fracture toughness of sucrose crystals using microindentation techniques.
The brittleness of pharmaceutical crystals influences their ability to form compacts of acceptable quality. While many macroscopic methods are available to elucidate the fracture behavior of materials, the porosity, inhomogeneity, and anisotropy of pharmaceutical compacts render it difficult to interpret the results of these tests. Microindentation techniques may be used to evaluate both the flow and the fracture characteristics of small crystals, so that it is not necessary to test compacts. The flow and fracture behavior of sucrose, the model substance used in this study, were anisotropic. The fracture surface energy, derived from the average fracture toughness value, is of the same order of magnitude as the surface free energy, indicating that sucrose fractures in a brittle manner.
Duncan-Hewitt
W C
WC
Faculty of Pharmacy, University of Toronto, Ontario, Canada.
Weatherly
G C
GC
D003460:Crystallization; D003720:Densitometry; D006244:Hardness; D008956:Models, Chemical; D013395:Sucrose / Q000032:analysis*; D013816:Thermodynamics
D013395:Sucrose