Nuclear magnetic resonance study of obsessive-compulsive disorder.
Magnetic resonance imaging (MRI) of the brains of 32 patients who met the DSM-III criteria for obsessive-compulsive disorder and of 14 normal subjects frequently revealed abnormalities, but none was specific to obsessive-compulsive disorder. Spin-lattice relaxation time (T1) for right frontal white matter was prolonged in the patients compared to the control subjects, and the patients had greater right-minus-left T1 differences for frontal white matter. Right-minus-left T1 differences in the orbital frontal cortex were strongly correlated with symptom severity in the unmedicated patients and in the patients with family histories of obsessive-compulsive disorder.
Garber
H J
HJ
UCLA Neuropsychiatric Institute.
Ananth
J V
JV
Chiu
L C
LC
Griswold
V J
VJ
Oldendorf
W H
WH
D000328:Adult; D001921:Brain / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D007839:Functional Laterality; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D011569:Psychiatric Status Rating Scales