title: Low-osmolality contrast media-induced ventricular fibrillation.
abstract: We evaluated the incidence of ventricular fibrillation with low-osmolality contrast media by right coronary arteriography in eleven adult mongrel dogs. Following insertion of the catheter into the right coronary artery, a test solution was infused for 25 seconds (total 11 mL) or until fibrillation occurred. The test solutions included 20% mannitol, ioxaglate, iopamidol, iotrolan, and sodium iopamidol, which contained 150 mEq/L sodium in solution. The incidences of ventricular fibrillation were 0% with iotrolan, 8.3% with sodium iopamidol, 10% with ioxaglate, and 100% with iopamidol and mannitol. These observations suggest that the absence of sodium ions is a critical factor in fibrillation, even in low-osmolality contrast media. The fact that iotrolan had the least arrhythmogenic property may be attributed to the 8 mEq/L of sodium ions in that agent.
authors.affiliation: Department of Radiology, Fukui Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hayakawa
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D004285:Dogs; D005260:Female; D007479:Iopamidol / Q000009:adverse effects; D007485:Ioxaglic Acid / Q000009:adverse effects; D008297:Male; D009994:Osmolar Concentration; D014283:Triiodobenzoic Acids / Q000009:adverse effects; D014693:Ventricular Fibrillation / Q000139:chemically induced*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C033300:iotrolan; D007479:Iopamidol; D007485:Ioxaglic Acid