title: Microbiological characterization of dactimicin: antibacterial activity towards gram-positive and gram-negative bacteria.
abstract: Dactimicin is the first aminoglycoside antibiotic of Dactylosporangium origin, consisting of a pseudo-disaccharide and an amino acid. It has also a formimidoyl moiety instead of the deoxystreptamine found in other aminoglycosides. The authors considered the antibacterial activity of dactimicin compared with amikacin, gentamicin and the fortimicins against Gram-positive and Gram-negative bacteria. Dactimicin showed remarkable antibacterial activity against all strains tested: in particular the MIC90 values ranged from 2 mg/l for Citrobacter sp. to 32 mg/l for Proteus sp. Methicillin-resistant staphylococci were poorly susceptible to all aminoglycosides tested, while dactimicin showed good activity against the methicillin-susceptible strains. MBCs and killing curves indicated that this drug is rapidly bactericidal against all strains tested.
authors.affiliation: Institute of Microbiology, University of Catania, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Stefani
authors.forename: E A
authors.initials: EA
authors.lastname: Debbia
authors.forename: G C
authors.initials: GC
authors.lastname: Schito
authors.forename: G
authors.initials: G
authors.lastname: Russo
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C023521:fortimicins; C023527:dactimicin