Growth and chemosensitivity of human head and neck cancers implanted under the kidney capsule of cyclosporine-immunosuppressed mice.
Thirty-seven of 54 human squamous cell head and neck carcinomas were grown successfully at first transplant generation xenografts under the kidney capsule of conventional mice immunosuppressed by daily treatment with 60 mg/kg of cyclosporine. Eighteen different tumors were evaluated for chemosensitivity to cis-diamminedichloroplatinum (cisplatin), 5-fluorouracil, and methotrexate. Thirty-nine percent of the tumors responded to cisplatin, 19% to 5-fluorouracil, and 33% to methotrexate. This assay response is consistent with the clinical response of human squamous head and neck carcinoma to these drugs used as single agents. It is hoped that this model will become useful for new drug testing and, in certain cases, for selection of chemotherapy for patients with refractory tumors.
Bennett
J A
JA
Department of Surgery, Albany Medical College, New York 12208.
Parnes
S M
SM
DeConti
R C
RC
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell; D002945:Cisplatin / Q000494:pharmacology; D003524:Cyclosporins / Q000627:therapeutic use*; D005472:Fluorouracil / Q000494:pharmacology; D006258:Head and Neck Neoplasms; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000494:pharmacology; D051379:Mice; D013370:Subrenal Capsule Assay
D000970:Antineoplastic Agents; D003524:Cyclosporins; D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate