title: Collagen and lipid biosynthesis in a case of epitheliogenesis imperfecta in cattle.
abstract: An analysis of the dermis and a study of collagen and lipid biosynthesis by fibroblast cultures were carried out in one case of epitheliogenesis imperfecta in a new born calf. This was found to be not only an epidermal disease with fissures and blisters within basal cells on the basement membrane but also a metabolic disease affecting the dermal fibroblasts. These fibroblasts showed a significant decrease in collagen biosynthesis with an increase in the percentage of type III collagen and also a decrease in the biosynthesis of lipids, especially glycerides and cholesterol.
authors.affiliation: Laboratoire de Biochimie, Faculté de Médecine, Saint Etienne, France.
authors.forename: J
authors.initials: J
authors.lastname: Frey
authors.forename: A
authors.initials: A
authors.lastname: Chamson
authors.forename: J M
authors.initials: JM
authors.lastname: Gourreau
authors.forename: J P
authors.initials: JP
authors.lastname: Gillet
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D008055:Lipids / Q000096:biosynthesis*; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012871:Skin Diseases / Q000235:genetics / Q000378:metabolism / Q000662:veterinary*
chemical_list: D008055:Lipids; D003094:Collagen