Zinc protects testicular injury induced by concurrent exposure to cadmium and lead in rats.
The effect of coexposure to lead and cadmium (each 50 ppm alone and 25 ppm in combination) on the testes of rats and the preventive role of zinc (50 ppm) was investigated by administering these metals through drinking water. Male weaned albino rats were exposed to these metals for 120 days. Testicular histology, sperm counts and sperm motility were studied in these rats. The animals coexposed to lead and cadmium exhibited much more pronounced pathological changes and reduced sperm counts compared to the animals exposed to either of the metals alone. Zinc supplementation to the lead + cadmium exposed rats revealed the protective effect of zinc on these parameters. The observed higher magnitude of changes in the testes of lead + cadmium exposed group seems to be due to the excessive cadmium accumulation.
Saxena
D K
DK
Industrial Toxicology Research Centre, Lucknow, India.
Murthy
R C
RC
Singh
C
C
Chandra
S V
SV
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005854:Germ Cells / Q000187:drug effects; D007854:Lead / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008297:Male; D051381:Rats; D012671:Seminiferous Tubules / Q000166:cytology / Q000378:metabolism; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects / Q000648:ultrastructure; D013733:Testicular Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D013737:Testis / Q000473:pathology; D015032:Zinc / Q000494:pharmacology*
D002104:Cadmium; D007854:Lead; D015032:Zinc