title: Life-threatening intracranial bleeding associated with the presence of an antifactor VII autoantibody.
abstract: This is a report of a 62-year-old male patient who had a bleeding disorder due to the presence of a factor VII (proconvertin) inhibitor. After treatment with a high-dose intravenous (IV) immunoglobulin failed and a life-threatening intracranial hemorrhage occurred, plasma exchanges were performed and immunosuppressive therapy was given. The factor VII inhibitor promptly disappeared, and the patient's parameters of hemostasis became normal. Even though a relapse occurred some months later, the patient responded to immunosuppressive therapy. No underlying disorder was evidenced after 17 months of follow-up.
authors.affiliation: Service d'Hématologie, Laboratoire Central d'Hématologie, Hôtel-Dieu, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Delmer
authors.forename: M H
authors.initials: MH
authors.lastname: Horellou
authors.forename: G
authors.initials: G
authors.lastname: Andreu
authors.forename: T
authors.initials: T
authors.lastname: Lecompte
authors.forename: F
authors.initials: F
authors.lastname: Rossi
authors.forename: M D
authors.initials: MD
authors.lastname: Kazatchkine
authors.forename: M
authors.initials: M
authors.lastname: Samama
authors.forename: R
authors.initials: R
authors.lastname: Zittoun
mesh_terms: D001327:Autoimmune Diseases / Q000097:blood*; D001778:Blood Coagulation Disorders / Q000276:immunology*; D002543:Cerebral Hemorrhage / Q000097:blood / Q000276:immunology*; D005167:Factor VII / Q000037:antagonists & inhibitors / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time
chemical_list: D005167:Factor VII