Interactions of the dimethyldiazaperopyrenium dication with nucleic acids. 1. Binding to nucleic acid components and to single-stranded polynucleotides and photocleavage of single-stranded oligonucleotides.
The binding of dimethyldiazaperopyrenium dication (1) with nucleosides, nucleotides, and single-stranded polynucleotides has been studied by photophysical methods. It has been shown that 1 may be a potential selective fluorescent probe for A- and/or T-rich polynucleotides. 1 efficiently cleaves oligonucleotides at guanine sites, under illumination with visible light, and therefore may be used as a sequence-specific artificial photonuclease.
Slama-Schwok
A
A
Chimie des Interactions Moléculaires, Collège de France, Paris.
Jazwinski
J
J
Béré
A
A
Montenay-Garestier
T
T
Rougée
M
M
Hélène
C
C
Lehn
J M
JM
D001483:Base Sequence; D001665:Binding Sites; D005456:Fluorescent Dyes; D009696:Nucleic Acids; D010777:Photochemistry; D011119:Polynucleotides; D011806:Quinolinium Compounds; D013053:Spectrophotometry
D005456:Fluorescent Dyes; D009696:Nucleic Acids; D011119:Polynucleotides; D011806:Quinolinium Compounds; C060279:dimethyldiazaperopyrenium