title: Anti-inflammatory activity of Aloe vera against a spectrum of irritants.
abstract: The authors have evaluated the spectrum of anti-inflammatory activity of A. vera in a number of models of inflammation in the hind paw of the experimental rat induced by kaolin, carrageenan, albumin, dextran, gelatin, and mustard. Croton oil was used in a topical model of inflammation to determine the oral activity and time-dependent dosing of A. vera. The authors found that A. vera was active in all models of inflammation. Of the various irritants tested, A. vera was especially active against gelatin-induced and kaolin-induced edema and, in contrast, had minimal activity when tested against dextran-induced edema. Oral activity of A. vera was demonstrated to be dependent on the presence of anthraquinones. The various irritant-induced edema models provided a broad spectrum of anti-inflammatory activity for A. vera.
authors.forename: R H
authors.initials: RH
authors.lastname: Davis
authors.forename: M G
authors.initials: MG
authors.lastname: Leitner
authors.forename: J M
authors.initials: JM
authors.lastname: Russo
authors.forename: M E
authors.initials: ME
authors.lastname: Byrne
mesh_terms: D000504:Aloe; D000818:Animals; D004195:Disease Models, Animal; D004487:Edema / Q000503:physiopathology; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology*; D007509:Irritants; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007509:Irritants