Intestinal absorption of aluminum in rats: stimulation by citric acid and inhibition by dinitrophenol.
The effects of citric acid and dinitrophenol on the mucosal uptake of aluminum (Al) and its appearance in the portal and systemic blood were investigated to establish the energy dependence of these processes. Therefore, the rat small intestine was perfused in situ with media containing 20 mmol Al/liter, with or without 5 mmol citric acid/liter, and with or without 0.1 mmol/liter of the metabolic inhibitor DNP. It is concluded that (1) the appearance of Al in systemic blood depends on the mucosal Al uptake after perfusion and the systemic blood level before perfusion and (2) citric acid stimulates and DNP inhibits both mucosal uptake and Al absorption in situ.
van der Voet
G B
GB
Toxicology Laboratory, University Hospital, Leiden, The Netherlands.
van Ginkel
M F
MF
de Wolff
F A
FA
D000535:Aluminum / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D000818:Animals; D002951:Citrates / Q000494:pharmacology*; D019343:Citric Acid; D004140:Dinitrophenols / Q000494:pharmacology*; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D002951:Citrates; D004140:Dinitrophenols; D019343:Citric Acid; D000535:Aluminum