title: Protective effect of an orally administered, highly potent somatostatin analog (RC-121) against absolute ethanol-induced hemorrhagic erosions of the rat gastric mucosa.
abstract: The cytoprotective effect of a highly potent somatostatin (SRIF) analog, RC-121 (H-D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2), was examined in the absolute ethanol-induced gastric erosion model in rat. This analog diminished the degree of gastric erosion by 50-55% when administered in i.p. doses of 2 x 10(-10)-10(-8) g/100 g body weight, or in oral doses of 10(-8)-2 x 10(-7) g/100 body weight. The orally active, highly potent SRIF analogs may be useful as therapeutic agents in the treatment of human peptic ulcer.
authors.affiliation: First Department of Medicine, Albert Szent-Györgyi Medical School, Szeged, Hungary.
authors.forename: F
authors.initials: F
authors.lastname: László
authors.forename: I
authors.initials: I
authors.lastname: Pávó
authors.forename: B
authors.initials: B
authors.lastname: Penke
authors.forename: G A
authors.initials: GA
authors.lastname: Bálint
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D005260:Female; D015282:Octreotide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000431:Ethanol; C053408:RC 121; D015282:Octreotide