Conformational transmission in condensed lipid model compounds. Chain packing modification by head-group-induced conformational changes in the glyceryl backbone.
On changing the phosphorus coordination from four to five via a trigonal bipyramidal geometry in phospholipid model systems, a conformational change is initiated around the C2-C3 linkage caused by enhanced electrostatic repulsion between the atoms O3 and O2, situated in the axis of the trigonal bipyramid. This is supported by the absence of conformational change upon substitution of O2 by methylene. With solid-state cross-polarization and magic-angle spinning 13C-NMR it is shown that such a conformational transmission leads to an increased packing density of the lipid chains. It seems to us that changes in lipid packing caused by conformational transmission may also occur when pentacoordination is present transiently, as under biological conditions, thereby inducing an activation of the transport proteins that are embedded in the membrane.
Meulendijks
G H
GH
Department of Organic Chemistry, Eindhoven University of Technology, The Netherlands.
De Haan
J W
JW
Van Genderen
M H
MH
Buck
H M
HM
D001643:Bridged Bicyclo Compounds / Q000032:analysis; D019086:Bridged Bicyclo Compounds, Heterocyclic; D055598:Chemical Phenomena; D002621:Chemistry; D004735:Energy Transfer; D008055:Lipids / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008560:Membrane Fluidity; D008968:Molecular Conformation; D017646:Organosilicon Compounds; D010100:Oxygen / Q000032:analysis; D010710:Phosphates / Q000032:analysis; D010743:Phospholipids / Q000032:analysis*; D012825:Silicon / Q000032:analysis
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D008055:Lipids; D017646:Organosilicon Compounds; D010710:Phosphates; D010743:Phospholipids; C015503:silatrane; D010100:Oxygen; D012825:Silicon