Peripheral neuropathy associated with mycosis fungoides.
A 56 year old man with acute sensory-motor polyneuropathy associated with mycosis fungoides is described. EMG studies showed diffuse signs of muscle denervation. A skin biopsy specimen showed a lymphocyte infiltration in the dermis, composed of mycosis cells characterised by deep invaginations of the nuclear membrane, and small Pautrier's microabscesses in the epidermis. Sural nerve biopsy revealed endoneurial fibrosis, a decreased number of myelinated fibres and acute axonal degeneration.
Comola
M
M
Department of Neurology, University of Milan, Italy.
Nemni
R
R
Comi
G
G
Corbo
M
M
Taccagni
G
G
Besana
C
C
Canal
N
N
D001706:Biopsy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000473:pathology*; D009410:Nerve Degeneration; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D011115:Polyneuropathies / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*; D013497:Sural Nerve / Q000473:pathology