title: [Malignant progression of oral leukoplakia].
abstract: The relation between oral leukoplakia and its malignant progression was clinicopathologically analysed by using the long-term follow-up cases treated in Cancer Institute Hospital, Tokyo, for 37 years (1950-1987). A total of 89 oral leukoplakia cases had been followed up for 11 years and 3 months on average, and the diagnosis of each case was histologically confirmed on biopsy. This series consisted of 56 male and 33 female patients. During the follow-up period, malignancy was found in 8 cases, at 5 years and 9 months on average after the diagnosis of leukoplakia. Among the cases being followed over 10 years, an incidence of malignant progression of benign leukoplakia was estimated as 10.25%. According to the size of leukoplakia, the lesions measuring over 1 cm in diameter showed higher risk for cancer development than the smaller ones. In the follow-up of leukoplakia, dysplasia was identified in 6 cases, and all of them were mild in degree. Moreover, cancer developed in 2 out of these 6 dysplasia cases.
authors.affiliation: Dept. of Head and Neck Tumors, Cancer Institute Hospital, Tokyo.
authors.forename: A
authors.initials: A
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Uchida
authors.forename: Y
authors.initials: Y
authors.lastname: Kimura
authors.forename: N
authors.initials: N
authors.lastname: Kazaoka
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007972:Leukoplakia, Oral / Q000473:pathology*; D008297:Male; D008875:Middle Aged