DNA sequences homologous to mitochondrial genes in nuclei from normal rat tissues and from rat hepatoma cells.
Using specific probes we show that sequences homologous to NADH dehydrogenase Subunit 6, and Cytochrome oxidase Subunits I, II, and III mitochondrial genes are present in nuclear DNA from various tissues. These mitochondrial-like sequences are also present in rat hepatoma nuclear DNA but with an abnormal organization and a higher copy number than in normal hepatocytes.
Corral
M
M
Institut de Pathologie Moléculaire, CNRS URA 1147, Paris, France.
Baffet
G
G
Kitzis
A
A
Paris
B
B
Tichonicky
L
L
Kruh
J
J
Guguen-Guillouzo
C
C
Defer
N
N
D000818:Animals; D001483:Base Sequence; D002467:Cell Nucleus / Q000032:analysis*; D003001:Cloning, Molecular; D015342:DNA Probes; D004272:DNA, Mitochondrial / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D008113:Liver Neoplasms / Q000032:analysis*; D008114:Liver Neoplasms, Experimental / Q000032:analysis*; D008930:Mitochondria, Liver / Q000032:analysis*; D009693:Nucleic Acid Hybridization; D051381:Rats; D011919:Rats, Inbred Strains; D012689:Sequence Homology, Nucleic Acid; D014407:Tumor Cells, Cultured / Q000032:analysis
D015342:DNA Probes; D004272:DNA, Mitochondrial