Infection of human T-cell leukemia virus type I and development of human T-cell leukemia lymphoma in patients with hematologic neoplasms: a possible linkage to blood transfusion.
Among 354 adult patients with either hematological malignancy or aplastic anemia, eight were positive for anti-HTLV-I antibodies; six of eight had received multiple transfusions. There was an approximately 3.5-fold increase (P less than .001) of HTLV-I seropositivity in the patients with hematologic disease (8 of 354, 2.23%) compared to the healthy adults older than 20 years (34 of 5252, .65%). Two hematological patients, one with Hodgkin's disease and one with acute promyelocytic leukemia, were found to be positive for HTLV-I, and developed and died of adult T-cell leukemia/lymphoma (ATL) subsequently. Both were long-term survivors of the primary disease and had received multiple transfusions. The latent period from blood transfusion to onset of ATL was 6 months and 11 years, respectively. Immunocompromised patients, who were seropositive for HTLV-I, may be at increased risk for ATL compared to healthy carriers of HTLV-I, and the latent period may be shorter.
Chen
Y C
YC
Department of Laboratory Medicine, National Taiwan University Medical School, Taipei, Republic of China.
Wang
C H
CH
Su
I J
IJ
Hu
C Y
CY
Chou
M J
MJ
Lee
T H
TH
Lin
D T
DT
Chung
T Y
TY
Liu
C H
CH
Yang
C S
CS
D000914:Antibodies, Viral / Q000032:analysis; D001803:Blood Transfusion; D015139:Blotting, Southern; D004273:DNA, Neoplasm / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000150:complications* / Q000628:therapy; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000382:microbiology*; D008223:Lymphoma / Q000150:complications* / Q000628:therapy; D008297:Male; D013997:Time Factors
D000914:Antibodies, Viral; D004273:DNA, Neoplasm; D004279:DNA, Viral