Inhibition of glyoxalase I by new squaric acid derivatives.
Synthesis and antiglyoxalase activity of new squaric acid derivatives have been studied. It has been established that the substitution of one hydroxyl group of the squaric acid (1,2-dihydroxy cyclobutene 3,4-dione) by an N-substituted group decreased the antiglyoxalase activity while the corresponding - 2 methoxy substituted derivatives were comparatively equipotent.
Kraus
J L
JL
Laboratoire de Chimie Biomoléculaire - Faculté des Sciences de Luminy Case 901, Marseille.
Castaing
M
M
D055598:Chemical Phenomena; D002621:Chemistry; D003503:Cyclobutanes / Q000138:chemical synthesis / Q000494:pharmacology*; D007791:Lactoylglutathione Lyase / Q000037:antagonists & inhibitors*; D008190:Lyases / Q000037:antagonists & inhibitors*
D003503:Cyclobutanes; D008190:Lyases; D007791:Lactoylglutathione Lyase; C030042:squaric acid