title: Very high dose cis-platinum (450 mg/sq m) in an infant with rhabdomyosarcoma.
abstract: The toxic effects of CDDP, erroneously given at 450 mg/sq m, are described. Life threatening gastrointestinal and myelotoxicity was observed as well as prolonged severe renal tubular acidosis without renal failure. No significant oto (brain-stem evoked responses) or neurotoxicity (EEG, neurologic examination and nerve conduction velocity) was detected indicating major age-related differences in the toxicity of this drug.
authors.affiliation: Department of Pediatric Hematology-Oncology, Giannina Gaslini Children's Hospital, Genova, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Haupt
authors.forename: G
authors.initials: G
authors.lastname: Perin
authors.forename: S
authors.initials: S
authors.lastname: Dallorso
authors.forename: M L
authors.initials: ML
authors.lastname: Garré
authors.forename: A
authors.initials: A
authors.lastname: Sobrero
mesh_terms: D002945:Cisplatin / Q000506:poisoning / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007223:Infant; D012208:Rhabdomyosarcoma / Q000188:drug therapy*
chemical_list: D002945:Cisplatin