[Participation of apolipoprotein E in the transport of cholesterol esters].
It is established in the in vitro experiments that subfraction of HDL3 is able of accepting cholesterol from the atherosclerosis-afflicted aorta intima. Apoprotein E has no effect on the acceptance of cholesterol from the intima by HDL3 particles. The role of the protein under its joint incubation with the aorta intima and HDL3 is reduced to the uptake of cholesterol esters from HDL3-particles enriched by cholesterol. It is assumed that apoprotein E under certain metabolic conditions can transfer esterified cholesterol from HDL-particles on other lipoproteins as well as into tissues impoverished in the cholesterol content.
Kozhevnikova
K A
KA
Petrova-Maslakova
L G
LG
Belova
E V
EV
Parfenova
N S
NS
Kliueva
N N
NN
D001011:Aorta / Q000378:metabolism / Q000502:physiology; D001057:Apolipoproteins E / Q000502:physiology*; D001161:Arteriosclerosis / Q000378:metabolism / Q000503:physiopathology; D001692:Biological Transport; D002499:Centrifugation, Density Gradient; D002788:Cholesterol Esters / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008075:Lipoproteins, HDL / Q000502:physiology
D001057:Apolipoproteins E; D002788:Cholesterol Esters; D008075:Lipoproteins, HDL
Uchastie apolipoproteina E v transporte éfirov kholesterina.