title: [Three cases of Torsades de pointes].
abstract: Torsades de Pointes is an atypical ventricular tachycardia, a characteristic sinusoidal twisting of QRS complex around the base line, first described by Dessertenne et al in 1966. Since their original description, many literatures including both reviews and case reports have been issued. However, the exact causes, mechanism and its true relation to usual ventricular tachycardia and fibrillation remain to be elucidated. In the present report, three cases of Torsades de Pointes (TDP) were described. All these patients revealed a prolonged QT and QTc interval as has been recognized at the occasion of TDP attacks together with low serum potassium concentration. In addition, one had hypertrophic cardiomyopathy (case 1), cholelithiasis (case 2) and uterus cancer (case 3), respectively. Regarding to the treatment, direct current counter shock was applied to terminate the TDP in all 3 cases, the correction of low serum potassium concentration was also done in each case. Lidocaine was ineffective in case 3 to terminate the TDP, while verapamil was effective in case 3 to convert TDP to normal sinus rhythm. In case 2, no antiarrhythmic drugs were applied, however, cardiac massage and normalization of serum potassium concentration succeeded to recover normal sinus rhythm. The diversity of the causes and treatments of TDP in these three cases was discussed in relation to the genesis of TDP.
authors.forename: H
authors.initials: H
authors.lastname: Nanimatsu
authors.forename: H
authors.initials: H
authors.lastname: Shibayama
authors.forename: A
authors.initials: A
authors.lastname: Koumatsu
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: T
authors.initials: T
authors.lastname: Saikawa
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.forename: R
authors.initials: R
authors.lastname: Takaki
authors.forename: Y
authors.initials: Y
authors.lastname: Tsunematsu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004206:Disopyramide / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000150:complications*; D008297:Male; D013610:Tachycardia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D014700:Verapamil / Q000627:therapeutic use*
chemical_list: D014700:Verapamil; D004206:Disopyramide