[Bile excretion system in endogenous hypercorticism syndrome].
Bile excretion and biochemical properties of bile were investigated in 86 patients with the endogenic hypercorticism syndrome, 78 patients with the Itsenko-Cushing disease and in 8 patients with corticosteroma. A considerable incidence of functional and organic biliary disorders was demonstrated. Changes in cholecyst contractility were recorded in 54.6% of the patients, with hypermotor dyskinesia (36.4%) prevailing. An excess of endogenic corticosteroids was frequently accompanied by a hypotonus of Oddi's sphincter (65.6%) or Lutkens' sphincter (67.2%). Chronic (stoneless) cholecystitis was diagnosed in 70.9% of the patients, cholelithiasis, in 16.3%, and cholecyst cholesterosis, in 3.5%. Adrenocortical hyperfunction was associated with natural changes in biochemical composition of the bile, such as excessive cholesterol and a relative deficiency of cholic acid and phospholipids which might be conducive to cholelithiasis. High incidence of biliary disturbances and their pattern should be taken into account in the treatment of patients with hypercorticism.
German
S V
SV
Lemeshko
Z A
ZA
Vaĭnshteĭn
T Ia
TIa
Petrova
E A
EA
D000293:Adolescent; D000308:Adrenocortical Hyperfunction / Q000150:complications*; D000328:Adult; D001646:Bile / Q000378:metabolism; D001649:Bile Duct Diseases / Q000209:etiology; D001660:Biliary Tract Diseases / Q000209:etiology*; D002764:Cholecystitis / Q000209:etiology; D002769:Cholelithiasis / Q000209:etiology; D003480:Cushing Syndrome / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
Zhelchevydelitel'naia sistema pri sindrome éndogennogo giperkortitsizma.