Influence of buthionine sulfoximine on the lethality of ifosfamide and ifosfamide-induced urotoxicity in mice.
Buthionine sulfoximine (500 mg/kg, i.p.), a glutathione-depleting agent, was found to increase the acute lethal toxicity and urotoxicity induced by ifosfamide in mice.
Ishikawa
M
M
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D019328:Buthionine Sulfoximine; D003543:Cysteamine / Q000633:toxicity; D005978:Glutathione / Q000378:metabolism; D007069:Ifosfamide / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives* / Q000633:toxicity; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects; D014570:Urologic Diseases / Q000139:chemically induced*
D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D003543:Cysteamine; D005978:Glutathione; D007069:Ifosfamide