Effect of food restriction on benzo(a)pyrene binding to DNA in Wistar rats.
A study was carried out to assess the binding of the carcinogen benzo[a]pyrene to DNA in different tissues under in vivo and in vitro conditions in Wistar rats which have been subjected to different levels of food restriction. The results showed that there was a significant increase in the binding of benzo[a]pyrene to hepatic DNA in food restricted animals in in vivo experimentation although this was not observed under in vitro conditions. There was a decrease in binding to pulmonary DNA and no change for renal DNA.
Jagadeesan
V
V
Food and Drug Toxicology Research Centre, National Institute of Nutrition, Hyderabad, A.P., India.
Krishnaswamy
K
K
D000818:Animals; D001564:Benzo(a)pyrene / Q000378:metabolism*; D001665:Binding Sites; D004247:DNA / Q000378:metabolism*; D005508:Food Deprivation; D008297:Male; D009748:Nutrition Disorders / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001564:Benzo(a)pyrene; D004247:DNA