title: [Potential cardiotonic agents. 2. Synthesis and pharmacologic properties of 5-(pyri-4-yl)- and 5-phenyl substituted 3-cyano-6-methyl-2-oxaalkylaminopyridines].
abstract: The authors describe the preparation, the physicochemical properties and the results of evaluation of positive inotropic and vasodilator activities in a series of 5-(4-pyridinyl)- and 5-phenyl-substituted 3-cyano-6-methyl-2-oxaalkylamino-pyridines. Some of the compounds are comparable in their positive inotropic potency to that of amrinone and cause, additionally, a decrease in blood pressure.
authors.affiliation: Akademie der Wissenschaften der DDR, Institut für Wirkstofforschung, Berlin.
authors.forename: E
authors.initials: E
authors.lastname: Klauschenz
authors.forename: A
authors.initials: A
authors.lastname: Rumler
authors.forename: V
authors.initials: V
authors.lastname: Hagen
authors.forename: A
authors.initials: A
authors.lastname: Hagen
authors.forename: S
authors.initials: S
authors.lastname: Heer
authors.forename: R
authors.initials: R
authors.lastname: Mitzner
authors.forename: H
authors.initials: H
authors.lastname: Niedrich
mesh_terms: D000631:Aminopyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000138:chemical synthesis*; D004285:Dogs; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D009570:Nitriles / Q000138:chemical synthesis / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000631:Aminopyridines; D002316:Cardiotonic Agents; D009570:Nitriles; D011725:Pyridines
vernacular_title: Potentielle Kardiotonika. 2. Mitteilung: Synthese und pharmakologische Eigenschaften von 5-(pyrid-4-yl)- und 5-phenylsubstituierten 3-Cyan-6-methyl-2-oxaalkylamino-pyridinen.