title: Effect of sorbitol- and xylitol-containing chewing gum on salivary microflora, saliva, and oral sugar clearance.
abstract: The effect of frequent use of a sorbitol-containing nicotine chewing gum on saliva secretion rate and buffer capacity and some oral bacteria was studied in 27 patients at a smoking cessation clinic. The effect was compared with that obtained after frequent use of a chewing gum containing xylitol in a second study in 14 subjects. The results showed that sorbitol-containing nicotine chewing gum had no significant effect on salivary numbers of oral streptococci and lactobacilli during a 3-month period of active chewing five times a day. Chewing on xylitol-containing gum caused a significant decrease in salivary S. mutans after 2 months but not after 3 months. No change in secretion rate or buffer capacity was observed in the two studies. Oral sugar clearance time was reduced after 3 months with a statistically significant difference to baseline values in subjects consuming the sorbitol-containing nicotine chewing gum.
authors.affiliation: Department of Cariology, Faculty of Odontology, University of Gothenburg, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Wennerholm
authors.forename: C G
authors.initials: CG
authors.lastname: Emilson
mesh_terms: D000328:Adult; D000368:Aged; D001419:Bacteria / Q000187:drug effects; D002021:Buffers; D002638:Chewing Gum; D015169:Colony Count, Microbial; D005260:Female; D005947:Glucose / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000031:analogs & derivatives; D011109:Polymethacrylic Acids; D011145:Polyvinyls; D012463:Saliva / Q000378:metabolism / Q000382:microbiology*; D013012:Sorbitol / Q000494:pharmacology*; D061485:Tobacco Use Cessation Devices; D014993:Xylitol / Q000494:pharmacology*
chemical_list: D002021:Buffers; D002638:Chewing Gum; D011109:Polymethacrylic Acids; D011145:Polyvinyls; D013012:Sorbitol; D009538:Nicotine; D005947:Glucose; D014993:Xylitol