title: Dioxins in cigarette smoke.
abstract: Dioxins in cigarettes, smoke, and ash were determined using gas chromatography/mass spectrometry. The total concentration of polychlorinated dibenzo-p-dioxins (PCDDs) in cigarette smoke was approximately 5.0 micrograms/m3 at the maximum level, whereas various congeners from tetra-octa-chlorodibenzo-p-dioxin (-CDD) were detected. Particullary, the total concentration of hepta-CDD congeners was the highest among these congeners. Mass fragmentograms of various PCDD congeners were similar to those in flue gas samples collected from a municipal waste incinerator. The PCDD congeners that were not present in the cigarettes were found in the smoke samples. The 2,3,7,8-TCDD toxic equivalent value--an index for effects on humans--for total PCDDs in smoke was 1.81 ng/m3 using the toxic factor of the United States Environment Protection Agency. Daily intake of PCDDs by smoking 20 cigarettes was estimated to be approximately 4.3 pg.kg body weight/day. This value was close to that of the ADIs: 1-5 pg.kg body weight/day reported in several countries. A heretofore unrecognized health risk was represented by the presence of PCDDs in cigarette smoke.
authors.affiliation: Department of Public Health, Akita University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Muto
authors.forename: Y
authors.initials: Y
authors.lastname: Takizawa
mesh_terms: D002845:Chromatography / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D004147:Dioxins / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D010947:Plants, Toxic; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives / Q000032:analysis*; D012906:Smoke / Q000032:analysis*; D014026:Nicotiana / Q000032:analysis*
chemical_list: D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D012906:Smoke