Micronucleus induction in mouse bone marrow by phenacetin administered intraperitoneally or orally.
The extent and time course of induction of micronucleated polychromatic erythrocytes (MNPCEs) in mouse bone marrow were examined after administration of phenacetin as an insoluble suspension in olive oil by intraperitoneal injection (i.p.) or gastric intubation (p.o.) to 2 strains of mice, MS/Ae and CD-1, at doses up to 1200 mg/kg. The toxicity of phenacetin and the sensitivity of micronucleus induction differed in the 2 strains, but there was little difference in the extent of MNPCEs induced by the 2 administration routes.
Hachiya
N
N
Department of Public Health, Akita University School of Medicine, Japan.
Aruga
F
F
Aida
M
M
Quan
T H
TH
Takizawa
Y
Y
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007441:Intubation, Gastrointestinal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000008:administration & dosage*; D010615:Phenacetin / Q000008:administration & dosage* / Q000633:toxicity
D009153:Mutagens; D010615:Phenacetin