title: Evaluation of a combination of tiletamine and zolazepam as an anesthetic for ferrets.
abstract: A combination of equal parts by weight of tiletamine hyrochloride and zolazepam hydrochloride was evaluated clinically in 12 adult male ferrets. Two dosage levels of 12 mg/kg and 22 mg/kg were evaluated. Both doses produced excellent immobilization, the length of which was dose dependent. However, only the higher dose consistently produced good muscle relaxation. Excessive pain upon infection was not noted nor was residual lameness evident. Electrocardiagraphically, notching of the QRS complex was noted at both doses. Anesthesia with poor analgesia occurred at the lower dose, while ferrets receiving the higher dose showed more variability in the degree of analgesia. It was concluded that this combination administered intramuscularly provided excellent immobilization, variable muscle relaxation and a generally smooth induction and recovery. At the higher dose, analgesia was adequate for minor surgical procedures of short duration.
authors.affiliation: Division of Laboratory Animal Medicine, University of North Carolina, Chapel Hill 27599.
authors.forename: A J
authors.initials: AJ
authors.lastname: Payton
authors.forename: J R
authors.initials: JR
authors.lastname: Pick
mesh_terms: D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D002335:Carnivora / Q000502:physiology*; D003510:Cyclohexanes / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005289:Ferrets / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D013992:Tiletamine / Q000494:pharmacology; D015041:Zolazepam / Q000494:pharmacology
chemical_list: D001381:Azepines; D003510:Cyclohexanes; D004338:Drug Combinations; D013992:Tiletamine; D015041:Zolazepam