title: Biotransformation of aryl alkylamines by Cunninghamella bainieri.
abstract: 1. Incubations of phenylethylamine and 11 of its analogues with Cunninghamella bainieri have been performed. 2. Products of all major routes of mammalian metabolism including ring and aliphatic hydroxylation, oxidative deamination, N-oxidation, N-dealkylation, and conjugation were found in extracts of the fungal incubation broths. 3. Metabolism was influenced by the nature and degree of substitution.
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
authors.forename: B C
authors.initials: BC
authors.lastname: Foster
authors.forename: R T
authors.initials: RT
authors.lastname: Coutts
authors.forename: F M
authors.initials: FM
authors.lastname: Pasutto
mesh_terms: D001711:Biotransformation; D006900:Hydroxylation; D015394:Molecular Structure; D009090:Mucorales / Q000378:metabolism*; D010084:Oxidation-Reduction; D010627:Phenethylamines / Q000378:metabolism / Q000493:pharmacokinetics*
chemical_list: D010627:Phenethylamines