title: Castration increases striatal D-2 dopamine receptors in mid-life rats.
abstract: Effect of castration on [3H]-spiperone binding in the striatum of mid-life/mature rats was investigated. Four weeks after castration an increase in D-2 dopamine receptors was noted, and this was partially reduced by testosterone. These results suggest that testosterone may regulate striatal D-2 dopamine receptors in an age-dependent manner.
authors.affiliation: Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: L
authors.initials: L
authors.lastname: Imamura
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D008297:Male; D009919:Orchiectomy; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology
chemical_list: D011954:Receptors, Dopamine; D013739:Testosterone