[The role of aluminum-induced inhibition of the intestinal absorption of calcium in the pathogenesis of aluminum osteopathy].
The aim of the study was to investigate the effect of aluminium on duodenal calcium absorption, the impairment of which can represent a pathogenic factor in the development of aluminium bone lesions. The authors investigated in the chick the effect of Al(OH)3 administered orally and of AlCl3 administered subcutaneously on the duodenal absorption of 47Ca, on serum concentration of calcium, phosphorous, aluminium and 1,25-dihydroxycholecalciferol and on bone morphology. Oral administration of Al(OH)3 for 8, 15, and 22 days was without any significant change. Subcutaneous administration of Al/Cl/3 for 8 day was associated with a significant increase in serum aluminium and 1,25-dihydroxycholecalciferol levels and with a significant decrease of the duodenal absorption of 47Ca. Decreased intestinal absorption of calcium may play a pathogenic role in the development of aluminium osteopathy. Increased serum 1,25-dihydroxycholecalciferol reflects presumably a compensatory mechanism of the lowered calcium absorption.
Blahos
J
J
Unité d'Endocrinologie, Faculté de Pédiatrie, Université Charles, Prague, Tchécoslovaquie.
Care
A D
AD
Abbas
M
M
Aaron
J
J
Porsova
I
I
D000535:Aluminum / Q000494:pharmacology*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000818:Animals; D001847:Bone Diseases / Q000209:etiology* / Q000378:metabolism; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000378:metabolism*; D002645:Chickens; D002712:Chlorides / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male
D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride; D000536:Aluminum Hydroxide; D000535:Aluminum; D002117:Calcitriol; D002118:Calcium
Le rôle de l'inhibition de l'absorption intestinale du calcium par l'aluminium dans la pathogénèse de l'ostéopathie aluminique.