[Mechanism of changes in amine binding to plasma proteins during allergy].
Blood plasma of healthy persons bound 13.13 +/- 1.07 mmol/l of p-phenylene diamine (PDA), histamine pectic index constituted 33.3 +/- 2.18%. In patients with neurodermitis and eczema both these patterns were markedly reduced. Unitiol (10(-3) mol/l) increased PDA binding and histamine level in vitro. The same concentration of cystamine decreased histamine pectic index in healthy persons. Importance of protein SH-groups in binding of amines is discussed.
Shleĭkin
A G
AG
Gor'kova
L B
LB
Pozhilenkova
K S
KS
Zvezdochkin
A G
AG
D001679:Biogenic Amines / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D003538:Cystamine / Q000494:pharmacology; D006632:Histamine / Q000097:blood; D006801:Humans; D006967:Hypersensitivity / Q000097:blood*; D066298:In Vitro Techniques; D010655:Phenylenediamines / Q000097:blood; D011485:Protein Binding; D014494:Unithiol / Q000494:pharmacology
D001679:Biogenic Amines; D001798:Blood Proteins; D010655:Phenylenediamines; D014494:Unithiol; D006632:Histamine; D003538:Cystamine
O mekhanizme izmeneniia sviazyvaniia aminov belkami plazmy krovi pri allergii.