title: Use of maximal expiratory flows to evaluate central airways obstruction in infants.
abstract: Partial expiratory flow-volume (PEFV) curves obtained by the rapid compression technique were employed to assess airway function in three infants with three different lesions of the central airways (vascular ring, congenital tracheal stenosis, subglottic polyp). Preoperatively, all three demonstrated severe flow limitation with a relatively constant forced expiratory flow over the tidal volume range. Postoperatively the PEFV curves changed to a normal convex shape, and the maximal expiratory flows at functional residual capacity (VmaxFRC) returned to normal. The PEFV curve adds to our physiologic assessment of the severity of the central airway obstruction in infants and to the efficacy of our therapeutic intervention.
authors.affiliation: Department of Pulmonology, James Whitcomb Riley Hospital for Children, Indiana University Medical School, Indianapolis 46223.
authors.forename: R S
authors.initials: RS
authors.lastname: Tepper
authors.forename: H
authors.initials: H
authors.lastname: Eigen
authors.forename: J
authors.initials: J
authors.lastname: Brown
authors.forename: R
authors.initials: R
authors.lastname: Hurwitz
mesh_terms: D000402:Airway Obstruction / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008448:Maximal Expiratory Flow Rate; D008449:Maximal Expiratory Flow-Volume Curves; D014135:Tracheal Stenosis / Q000150:complications / Q000503:physiopathology*