title: Inhibitory actions of amiodarone on the isolated rabbit heart and aorta.
abstract: 1. The inhibitory actions of amiodarone on the isolated rabbit heart and aorta have been studied. 2. Amiodarone inhibited vasopressin- and ergonovine-induced coronary spasm, starting from a concentration of 10(-7) M which did not affect myocardial contractility to 10(-4) M, which decreased myocardial contractility. 3. Sinus node activity was largely unaffected even when the highest dose of 10(-4) M was used. 4. Amiodarone did not modify the smooth muscle contraction in rabbit aorta strips precontracted with noradrenaline or potassium. 5. Comparison with other inhibitors of the cardiovascular system (alpha- and beta-blockers, nitrates, calcium entry blockers) points out a peculiar pharmacological profile of amiodarone and indicates some doubts about its presumed anti-adrenergic properties.
authors.affiliation: Cattedra di Cardiologia, Università di Brescia e di Parma, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Raddino
authors.forename: E
authors.initials: E
authors.lastname: Poli
authors.forename: G
authors.initials: G
authors.lastname: Pelà
authors.forename: M
authors.initials: M
authors.lastname: Gargano
authors.forename: C
authors.initials: C
authors.lastname: Manca
mesh_terms: D000638:Amiodarone / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D011817:Rabbits
chemical_list: D000638:Amiodarone