The influence of zinc and citrate on urease-induced urine crystallisation.
Zinc reduced and citrate promoted the urease-induced pH increase in synthetic urine. Secondary to this, the precipitation of magnesium ammonium phosphate and calcium phosphate was influenced. Independent of this pH-related effect, zinc also increased the precipitation of magnesium ammonium phosphate and decreased the calcium phosphate precipitation. These observations were not totally reproducable in human urine.
Hedelin
H
H
Department of Urology, Sahlgrenska Hospital, University of Göteborg, Sweden.
Grenabo
L
L
Hugosson
J
J
Pettersson
S
S
D000328:Adult; D002951:Citrates / Q000494:pharmacology*; D019343:Citric Acid; D003460:Crystallization; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D014510:Urease / Q000494:pharmacology*; D014556:Urine / Q000187:drug effects*; D015032:Zinc / Q000494:pharmacology*
D002951:Citrates; D019343:Citric Acid; D014510:Urease; D015032:Zinc