Motoneurons reinnervate skeletal muscle after ventral root implantation into the spinal cord of the cat.
By use of intracellular recording and staining with horseradish peroxidase it was found that alpha and probably also gamma motoneurons were able to reinnervate ventral root implants after an avulsion of ventral roots at the spinal cord surface in the cat. The reinnervation of the implant was achieved after an initial growth of new axons in central nervous system tissue. Reinnervating neurons could be excited or inhibited by segmental reflex activity and their axons could conduct nerve impulses. The character of muscle twitch responses elicited by electrical stimulation of implanted roots strongly indicated that denervated muscles were reinnervated by new motor axons via the implant.
Cullheim
S
S
Department of Anatomy, Karolinska Institute, Stockholm, Sweden.
Carlstedt
T
T
Lindå
H
H
Risling
M
M
Ulfhake
B
B
D000200:Action Potentials; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D009046:Motor Neurons / Q000502:physiology*; D009132:Muscles / Q000294:innervation* / Q000502:physiology; D009416:Nerve Regeneration; D013116:Spinal Cord / Q000502:physiology*; D013126:Spinal Nerve Roots / Q000502:physiology / Q000637:transplantation*