title: Influence of electric foot shock on pharmacokinetics of isosorbide dinitrate orally administered to rats.
abstract: The influence of emotional stress on the pharmacokinetics of isosorbide dinitrate (ISDN) was studied in rats. Plasma levels of orally administered ISDN and metabolites (5-isosorbide mononitrate and 2-isosorbide mononitrate) were lower in rats emotionally stressed by foot shock than in non-stressed control rats. The decrease in the ISDN levels may be mainly due to the delay of drug absorption from the gastrointestinal tract.
authors.affiliation: Department of Hospital Pharmacy, Okayama University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Gomita
authors.forename: K
authors.initials: K
authors.lastname: Furuno
authors.forename: Y
authors.initials: Y
authors.lastname: Araki
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004597:Electroshock; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000097:blood / Q000378:metabolism*
chemical_list: C030398:isosorbide-2-mononitrate; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate