title: [Effect of intramolecular energetic barriers on conformation-non-equilibrium states of protein globules in ensemble].
abstract: Within the Blumenfeld's model interpretation theoretical investigations of conformation relaxation of the protein globule were carried out. Analytical expressions describing the relaxation time and cyclic frequency of enzymes synchronization by arbitrary number of metastable states and unequal probabilities of transitions between them were found. It was shown that inequality of activation energies affects the frequency and number of cycles of enzymes synchronous work to a considerably greater degree, than the relaxation time of initial disturbance. The number of macromolecules in the definite conformation state was evaluated and conditions of experimental observation of synchronization were discussed.
authors.forename: E A
authors.initials: EA
authors.lastname: Barannik
authors.forename: A V
authors.initials: AV
authors.lastname: Siniugin
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D008433:Mathematics; D011487:Protein Conformation
vernacular_title: Vliianie vnutrimolekuliarnyukh énergeticheskikh bar'erov na konformatsionno-neravnovesnye sostoianie belkovykh globul v ansamble.