Haem biosynthesis in the unconjugated hyperbilirubinaemias: observations in the Gunn rat model.
Disturbances of the enzymes of haem biosynthesis have been reported in patients with unconjugated hyperbilirubinaemia. We have examined the excretion of haem precursors in the Gunn rat which suffers from severe unconjugated hyperbilirubinaemia. In urine, levels of aminolaevulinic acid and total porphyrin were significantly reduced when compared to controls. In feces both coproporphyrin and protoporphyrin levels were reduced in Gunn rats, the former being more affected. Blood porphyrin levels in control and Gunn rats were similar.
Graham
A M
AM
University Department of Medicine, Western Infirmary, Glasgow, Scotland.
McColl
K E
KE
Moore
M R
MR
D000622:Aminolevulinic Acid / Q000652:urine; D000818:Animals; D001663:Bilirubin / Q000097:blood; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000032:analysis; D006418:Heme / Q000096:biosynthesis*; D006933:Hyperbilirubinemia, Hereditary / Q000150:complications*; D011166:Porphyrins / Q000097:blood / Q000652:urine; D011524:Protoporphyrins / Q000097:blood; D051381:Rats; D011911:Rats, Gunn; D011919:Rats, Inbred Strains
D011166:Porphyrins; D011524:Protoporphyrins; D006418:Heme; D000622:Aminolevulinic Acid; D001663:Bilirubin