[Animal experiment studies of the bile acid effect in obstructive ileus].
Bile acids are detergents with a direct effect on the endotoxin lipopolysaccharide molecule in vitro. This study investigates the effect of orally administered sodium deoxycholate on the survival of rats in the state of ileus. First observations indicated, that the administration of sodium deoxycholate results in a longer survival time. The results are explained by the antiendotoxic (detergent) effect of bile acids.
Ruschen
B
B
Chirurgischen Klinik, Bezirkskrankenhauses Potsdam.
Bertok
L
L
D000818:Animals; D003108:Colonic Diseases / Q000188:drug therapy* / Q000401:mortality; D003840:Deoxycholic Acid / Q000008:administration & dosage*; D005260:Female; D007415:Intestinal Obstruction / Q000188:drug therapy* / Q000401:mortality; D011379:Prognosis; D051381:Rats; D011919:Rats, Inbred Strains
D003840:Deoxycholic Acid
Tierexperimentelle Untersuchungen zum Gallensäureeffekt beim Obturationsileus.