Surrogate endpoints in clinical trials: ophthalmologic disorders.
We examined three examples of surrogate observations in ophthalmology. The first represents a simple case: the status of one eye is used as a surrogate for the (unobservable) status of the opposite eye in the same individual. The second and third examples represent possible extrapolation of long term results on the basis of early changes. These examples are used to illustrate the assumptions intrinsic in the use of surrogate variables.
Hillis
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Texas A&M University, Temple.
Seigel
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D
D002986:Clinical Trials as Topic / Q000379:methods*; D005128:Eye Diseases / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D012107:Research Design