[Results of active immunotherapy of children with acute lymphoblastic leukemia using cultured lymphoblast cell lines during remission].
The paper is concerned with the use of continuous cultures of lymphoblast lines in 16 patients with acute lymphoblastic leukemia under remission in order to raise the efficacy of routine treatment. In the group under study, the remission appeared to be threefold longer than in 17 controls who received only chemotherapy at all the treatment stages. Immunologic studies revealed the stimulating effect of immunotherapy with a two-four-fold increase in the levels of serum IgG and IgM accompanied by the appearance of and increment in the spectrum of cytotoxic antibodies.
Makhonova
L A
LA
Maiakova
S A
SA
Skorikova
A S
AS
Gavrilova
I E
IE
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007114:Immunization; D007167:Immunotherapy / Q000379:methods*; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000628:therapy*; D012074:Remission Induction
Rezul'taty aktivnoĭ immunoterapii kletkami perevivaemykh limfoblastoidnykn liniĭ deteĭ s ostrym limfoblastnym leĭkozom v periode remissii.