title: [The reaction to heparin in patients with burn toxemia during extracorporeal detoxification].
abstract: The comparison of sensitivity to heparin before hemosorption in burn patients with high level of the blood middle molecular peptides before the operation on the heart in patients with rheumatic cardiac defect without changes in the blood peptide level was carried out. In the model experiments, the influence of a fraction of the middle molecular peptides obtained from the blood of healthy and burned dogs on the effects of heparin and protamine sulfate, and as well on thrombocytic aggregation was studied. The role of the middle molecular peptides in the alteration of response to heparin in burn disease is discussed.
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Kholodov
authors.forename: B M
authors.initials: BM
authors.lastname: Val'dman
authors.forename: R I
authors.initials: RI
authors.lastname: Lifshits
authors.forename: A S
authors.initials: AS
authors.lastname: Puzhevskiĭ
authors.forename: A G
authors.initials: AG
authors.lastname: Nalimov
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects*; D002056:Burns / Q000628:therapy*; D006464:Hemoperfusion; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D010455:Peptides / Q000097:blood; D014115:Toxemia / Q000628:therapy*
chemical_list: D010455:Peptides; D006493:Heparin
vernacular_title: Osobennosti reaktsii na geparin u bol'nyh s ozhogovoĭ toksemieĭ pri ékstrakorporal'noĭ detoksikatsii.