title: Lack of extracellular slime effect on treatment outcome of Staphylococcus epidermidis experimental endocarditis.
abstract: We studied the response of two slime negative Staphylococcus epidermidis strains (NS1 and NS2) and one slime producing strain (S1) to treatment with vancomycin in the rabbit catheter-induced endocarditis model. All micro-organisms had vancomycin minimal inhibitory concentration and minimal bactericidal concentration of 4 mg/l. Three days after infection, treatment with vancomycin 25 mg/kg every 12 h was begun and continued for 4 days. Cardiac valve vegetations were harvested 12 h after the last dose of vancomycin and cultured quantitatively. In treated animals the mean +/- S.D. log10 colony forming units per g of cardiac valve vegetation were 1.6 +/- 0.1 for NS1, 4.4 +/- 1.9 for NS2, and 2.3 +/- 1.2 for S1. Slime production did not influence the results of vancomycin therapy of S. epidermidis experimental endocarditis. Other factors may cause strain-dependent variability in response to antimicrobial treatment in this model.
authors.affiliation: Mayo Clinic, Rochester, MN 55905.
authors.forename: J M
authors.initials: JM
authors.lastname: Steckelberg
authors.forename: M R
authors.initials: MR
authors.lastname: Keating
authors.forename: M S
authors.initials: MS
authors.lastname: Rouse
authors.forename: W R
authors.initials: WR
authors.lastname: Wilson
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000382:microbiology*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000502:physiology*; D014640:Vancomycin / Q000627:therapeutic use*
chemical_list: D014640:Vancomycin