Intrapericardial instillation of OK-432 for the management of malignant pericardial effusion: report of three cases.
Three patients with cardiac tamponade caused by malignancy were treated by pericardiocentesis with intrapericardial OK-432 instillation. The underlying disease was adenocarcinoma of unknown origin, breast cancer and multiple myeloma. Under electrocardiographic monitoring, a polyethylene catheter with several side holes was inserted into the pericardial sac, and after a maximal volume of fluid was withdrawn, 5 KE of OK-432 diluted in 20 ml of saline was instilled through the catheter. All the patients who received intrapericardial OK-432 therapy obtained complete control of pericardial effusion for more than 30 days. The side effects were fever, chills and chest pain which were easily controlled by antipyretics.
Imamura
T
T
Department of Internal Medicine, Miyazaki Prefectural Hospital.
Tamura
K
K
Taguchi
T
T
Makino
S
S
Seita
M
M
D000230:Adenocarcinoma / Q000150:complications; D000328:Adult; D001688:Biological Products / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000150:complications; D002305:Cardiac Tamponade / Q000209:etiology; D002408:Catheters, Indwelling; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications; D010490:Pericardial Effusion / Q000150:complications / Q000188:drug therapy*; D010844:Picibanil / Q000008:administration & dosage*
D001688:Biological Products; D010844:Picibanil