title: The effect of amygdala kindled seizures on locus coeruleus activity.
abstract: Locus coeruleus (LC) neuronal activity was recorded in anesthetized and in awake behaving rats during the production of amygdala afterdischarges (AD's) using kindling protocol. Both LC multiple and single unit discharges were temporally correlated with the appearance of AD's in the amygdala. Seizures were manifested in single unit activity as significant increases in firing rate. In awake animals, a bursting pattern of discharges was observed. We postulate that the observed changes in the LC activity pattern may have a modulatory role in the development of kindled seizures.
authors.affiliation: Department of Physiology, University of New Mexico School of Medicine, Albuquerque 87131.
authors.forename: C A
authors.initials: CA
authors.lastname: Jimenez-Rivera
authors.forename: G K
authors.initials: GK
authors.lastname: Weiss
mesh_terms: D000200:Action Potentials; D000679:Amygdala / Q000503:physiopathology*; D000818:Animals; D007696:Kindling, Neurologic; D008125:Locus Coeruleus / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains