A novel pathway for transversion mutation induced by dCTP misincorporation in a mutator strain of CHO cells.
Intracellular imbalances of dCTP produce both T----C transitions and an unusual class of transversions (A----C) at the aprt locus of CHO cells. Our data suggest that this transversion pathway is the consequence of dCTP:T mispairs which are not efficiently proofread during DNA replication.
Phear
G
G
Clare Hall Laboratories, Imperial Cancer Research Fund, South Mimms, Hertfordshire, United Kingdom.
Meuth
M
M
D000818:Animals; D001482:Base Composition; D001483:Base Sequence; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004260:DNA Repair; D004261:DNA Replication; D003845:Deoxycytosine Nucleotides / Q000235:genetics* / Q000378:metabolism; D005260:Female; D009154:Mutation; D010053:Ovary
D003845:Deoxycytosine Nucleotides; C024107:2'-deoxycytidine 5'-triphosphate