Studies on indomethacin as a potentiator for hyperthermic and radiation responses in a mouse fibrosarcoma.
Indomethacin, a non-steroidal anti-inflammatory drug which is also a calcium antagonist and an inhibitor of prostaglandin synthesis was observed to have a chemotherapeutic effect in a mouse fibrosarcoma. More significantly, administration of the drug before exposure to either radiation or hyperthermia, enhanced their effects. Apart from tumor growth delay, tumor cures were also observed in all the three modalities tested. The data suggests a potential anti-cancer role for indomethacin in combination modalities.
Shenoy
M A
MA
Radiation Biology Section, Bhabha Atomic Research Centre, Bombay, India.
Singh
B B
BB
D000818:Animals; D000970:Antineoplastic Agents; D003131:Combined Modality Therapy; D005354:Fibrosarcoma / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D006979:Hyperthermia, Induced; D007213:Indomethacin / Q000627:therapeutic use*; D051379:Mice; D011838:Radiation-Sensitizing Agents; D012513:Sarcoma, Experimental / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*
D000970:Antineoplastic Agents; D011838:Radiation-Sensitizing Agents; D007213:Indomethacin