title: Intrathecal baclofen infusion. Effect on bladder management programs in patients with myelopathy.
abstract: Intrathecal administration of Baclofen, a GABA agonist, through an implantable drug delivery pump has been demonstrated to be effective in the treatment of limb spasticity in patients with myelopathy. Three patients, followed before and after pump placement, experienced satisfactory spasticity relief and improvement in areas of self-care and mobility. Improvement in the bladder management programs of each patient was noted. These changes coincided with improvement on urodynamic studies, defined as either an increase in bladder capacity or a decrease in sphincter dyssynergia. Changes in bladder function were associated with the initiation of intrathecal therapy and with changes in pump-delivered dosages. In selected patients, intrathecal baclofen infusion can have a beneficial effect on bladder management programs.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Case Western Reserve University, Cleveland Metropolitan General/Highland View Hospital, OH 44109.
authors.forename: F
authors.initials: F
authors.lastname: Frost
authors.forename: J
authors.initials: J
authors.lastname: Nanninga
authors.forename: R
authors.initials: R
authors.lastname: Penn
authors.forename: S
authors.initials: S
authors.lastname: Savoy
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000328:Adult; D001418:Baclofen / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D009128:Muscle Spasticity / Q000188:drug therapy; D010264:Paraplegia / Q000150:complications; D001743:Urinary Bladder / Q000187:drug effects / Q000503:physiopathology; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D014563:Urodynamics / Q000187:drug effects
chemical_list: D001418:Baclofen