title: Periodic hyperammonemic encephalopathy associated with a ureterosigmoidostomy.
abstract: Ureterosigmoidostomy, a urinary diversion procedure performed for treatment congenital urologic defects or bladder cancer, may be associated with hyperammonemia. A delayed periodic encephalopathy, characterized by dysarthria, ataxia, and coma, developed in a 44-year-old woman who had undergone this procedure. Hyperammonemia-associated neurotoxicity resolved after surgical revision of the ureterosigmoidostomy to a uretero-ileostomy. Therefore, a treatable episodic encephalopathy may occur in association with hyperammonemia in patients who have undergone ureterosigmoidostomy.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN 55905.
authors.forename: G D
authors.initials: GD
authors.lastname: Cascino
authors.forename: J M
authors.initials: JM
authors.lastname: Jensen
authors.forename: L A
authors.initials: LA
authors.lastname: Nelson
authors.forename: H S
authors.initials: HS
authors.lastname: Schutta
mesh_terms: D000328:Adult; D000641:Ammonia / Q000097:blood*; D001928:Brain Diseases, Metabolic / Q000097:blood* / Q000175:diagnosis; D012809:Colon, Sigmoid / Q000601:surgery; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery; D012086:Reoperation; D014519:Ureterostomy / Q000379:methods; D014547:Urinary Diversion / Q000009:adverse effects*
chemical_list: D000641:Ammonia