Histamine-elicited drinking in weanling and adult rats.
A total of 260 male and female adult (60-70 days of age) and weanling (22-25 days of age) Sprague-Dawley derived rats were used in these experiments. Subcutaneous administration of histamine (HA) elicited drinking in a dose-dependent manner for both ages tested, although the threshold dose varied with age. A dose of 5.0 mg/kg HA elicited significant increases in water intake for adults, whereas for weanlings a dose of 20 mg/kg HA was necessary. Adult rats exhibited decreased latency to drink after all doses of HA tested, whereas for weanlings, decreased latency was evident only after doses of HA sufficient to elicit increases in water intake. Combined antagonism of H1 and H2 receptors for HA, using dexbrompheniramine and cimetidine, respectively, inhibited HA-elicited drinking in adults and weanlings. Further investigation of the ontogeny of histamine- and food-related drinking may provide a useful approach to examine the physiological mechanisms underlying fluid consumption in adult animals and as they are gradually elaborated during ontogeny.
Specht
S M
SM
Department of Psychology, State University of New York, Binghamton 13901.
Spear
L P
LP
D000818:Animals; D001921:Brain / Q000187:drug effects; D001977:Brompheniramine / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D011969:Receptors, Histamine H1 / Q000187:drug effects; D011970:Receptors, Histamine H2 / Q000187:drug effects; D014886:Weaning
D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; C015121:dexbrompheniramine; D002927:Cimetidine; D006632:Histamine; D001977:Brompheniramine