An antitumor principle from Euphorbia lathyris.
The extract of seeds of Euphorbia lathyris L. showed antitumor activity against Sarcoma 180 ascites in mice. Systematic fractionation of the extract led to the characterization of ingenol-3-hexadecanoate as an active principle, together with an inactive diterpene ingenol-20-hexadecanoate.
Itokawa
H
H
Ichihara
Y
Y
Watanabe
K
K
Takeya
K
K
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010946:Plants, Medicinal / Q000032:analysis*; D012510:Sarcoma 180 / Q000188:drug therapy*
D000972:Antineoplastic Agents, Phytogenic