title: Plasma free dopamine in human hypertension.
abstract: The concentration of plasma free dopamine (PDA) is said to be much lower than that of other catecholamines and its physiological significance remains unclear. Our recent studies using a newly developed radioenzymatic method disclosed the fairly distinctive features of PDA in patients with various types of hypertension. PDA was also confirmed as a variable responsive to postural change, dietary sodium loading and dopamine receptor antagonist. The results suggest that PDA could be a sensitive marker to represent the peripheral dopaminergic function, which might play an inherent role as a physiological regulator responsible for the cardiovascular and endocrine system.
authors.affiliation: Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Miura
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Sano
authors.forename: T
authors.initials: T
authors.lastname: Ohzeki
authors.forename: Y
authors.initials: Y
authors.lastname: Meguro
authors.forename: T
authors.initials: T
authors.lastname: Sugawara
authors.forename: T
authors.initials: T
authors.lastname: Noshiro
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Abe
mesh_terms: D004032:Diet; D004298:Dopamine / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008722:Methods; D008787:Metoclopramide / Q000494:pharmacology; D012016:Reference Values; D012964:Sodium / Q000494:pharmacology
chemical_list: D012964:Sodium; D008787:Metoclopramide; D004298:Dopamine