title: Antitumoral activity of a xanthate compound. I. Cytotoxicity studies with neoplastic cell lines in vitro.
abstract: Xanthate derivatives were shown previously to display antitumor activity against transformed fibroblasts and lymphoma cells in combination with monocarboxylic acids [1]. Various malignant cell lines of human origin were treated in vitro to explore the range of antitumoral activity of the compounds. The combination of tricyclodecan-9-yl-xanthogenate (D 609) with undecanoic acid (C11) exerted dose dependent cytotoxic and antiproliferative effects on cell lines both from solid tumors (glioblastomas, colon-carcinomas) and hematological diseases (lymphomas, CML/BC). Additionally, the combination of D 609/C11 was able to kill both methotrexate- and adriamycin-resistant L 1210 and S 180 cells, indicating that there is no cross-resistance for these drugs and D 609/C11 in vitro.
authors.affiliation: Department of Medicine I, Technische Universität, Munich, F.R.G.
authors.forename: H D
authors.initials: HD
authors.lastname: Schick
authors.forename: E
authors.initials: E
authors.lastname: Amtmann
authors.forename: W E
authors.initials: WE
authors.lastname: Berdel
authors.forename: S
authors.initials: S
authors.lastname: Danhauser-Riedl
authors.forename: A
authors.initials: A
authors.lastname: Reichert
authors.forename: G
authors.initials: G
authors.lastname: Steinhauser
authors.forename: J
authors.initials: J
authors.lastname: Rastetter
authors.forename: G
authors.initials: G
authors.lastname: Sauer
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000008:administration & dosage; D004351:Drug Resistance; D005227:Fatty Acids / Q000008:administration & dosage; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D009636:Norbornanes; D013859:Thiocarbamates; D013871:Thiones / Q000008:administration & dosage; D014407:Tumor Cells, Cultured
chemical_list: D001952:Bridged-Ring Compounds; D005227:Fatty Acids; D009636:Norbornanes; D013859:Thiocarbamates; D013871:Thiones; C016173:undecanoic acid; C046498:tricyclodecane-9-yl-xanthogenate