[Prolonged effect of an antacid treatment on changes in gastric potential difference induced by aspirin in man].
In ten healthy volunteers, we evaluated the effects of a 6 days antacid treatment (Rocgel) on the aspirin induced changes in gastric potential difference (PD). In this placebo controlled cross-over study, PD was measured twelve hours after the last take of the antacid. Aspirin induced drop of PD was less pronounced after antacid compared to placebo; maximal fall of PD and area upper the curve decreased (p less than 0.001). This effect was observed twelve hours after the last take of the antacid. It may suggested a long-term protective effect on the gastric mucosa.
Bergmann
J F
JF
Simoneau
G
G
Dorf
G
G
Caulin
C
C
Segrestaa
J M
JM
D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D000863:Antacids / Q000494:pharmacology*; D001241:Aspirin / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D008297:Male; D011897:Random Allocation; D013270:Stomach / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D000863:Antacids; D001241:Aspirin
Effect prolongé d'un traitement anti-acide sur les modifications de la différence de potential gastrique induites par l'asprine chez l'homme.