[Validation of indirect myocardial parameters of oxygen consumption in patients with normal and pathologically changed ventricular function].
Five frequently used hemodynamic oxygen consumption parameters were compared with the directly measured myocardial oxygen consumption (MVO2) in 28 patients with different heart diseases (4 without heart disease, 2 with mitral valve prolapse, 20 with coronary artery disease with or without left ventricular dysfunction, 2 with mitral regurgitation, 1 with hypertrophic obstructive cardiomyopathy and 3 with left ventricular hypertrophy due to hypertension). In most patients pressure-rate product (r = 0.908), tension-time index (r = 0.977), triple product (r = 0.970), pressure-work index (r = 0.954) and the additive parameter Et (r = 0.994) correlated relatively close with MVO2 under conditions of normal or low inotropic stimulation. Already during a moderately enhanced contractile state, tension-time index (r = 0.855), triple product (r = 0.873) and pressure-work index (r = 0.906) lose their close correlations with MVO2. Only pressure-rate product (r = 0.933) and Et (r = 0.982) remained reliable predictors of MVO2 also under these conditions of moderate positive inotropic stimulation.
Kahles
H
H
Medizinische Klinik, Universität Würzburg.
Dreyling
M
M
Kaposciok
J
J
Riegger
A J
AJ
Schanzenbächer
P
P
Kromer
E P
EP
Maisch
B
B
Kochsiek
K
K
D000328:Adult; D000368:Aged; D002312:Cardiomyopathy, Hypertrophic / Q000503:physiopathology; D003326:Coronary Circulation; D003327:Coronary Disease / Q000503:physiopathology; D005260:Female; D006331:Heart Diseases / Q000503:physiopathology*; D006339:Heart Rate; D006352:Heart Ventricles / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000503:physiopathology; D008945:Mitral Valve Prolapse / Q000503:physiopathology; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption
Validisierung indirekter myokardialer Sauerstoffverbrauchsparameter bei Patienten mit normaler und pathologisch veränderter Ventrikelfunktion.