title: Intermediate-dose cytosine arabinoside in the treatment of recurrent or refractory non-Hodgkin's lymphoma.
abstract: Twelve patients with recurrent or refractory non-Hodgkin's lymphoma (NHL) were treated with an intermediate-dose of cytosine arabinoside (CA) by continuous i.v. infusion in combination with daunorubicin (DNR). Of the 10 patients evaluated, one obtained a complete response (CR) and three partial responses (PR), and an almost complete disappearance of the tumor for three weeks (minor response) was seen in two patients. Severe myelosuppression was a dose-limiting factor. Intermediate-dose CA is effective for recurrent or refractory NHL but it needs to be combined with the proper partner drugs to obtain better therapeutic results.
authors.affiliation: Division of Hematology-Chemotherapy, Chiba Cancer Center Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Takagi
authors.forename: C
authors.initials: C
authors.lastname: Sakai
authors.forename: M
authors.initials: M
authors.lastname: Oguro
mesh_terms: D000328:Adult; D000368:Aged; D003561:Cytarabine / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007958:Leukocyte Count / Q000187:drug effects; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count / Q000187:drug effects; D017713:Platelet Transfusion; D012008:Recurrence; D012074:Remission Induction
chemical_list: D003561:Cytarabine