Systemic lupus erythematosus of childhood onset: correlation between T cells expressing early and late activation antigens and disease activity.
Correlation between T cell phenotypes, especially activated T cells expressing early (EA1) and late (HLA-DR) activation antigens and clinical features were investigated in 22 patients with systemic lupus erythematosus (SLE) of childhood onset. Percentages of T cells expressing EA1 and HLA-DR in 22 patients with SLE were significantly higher than those in controls. Comparison of T cell phenotypes between patients with active and inactive SLE showed that eight patients with active disease had significantly increased percentages of HLA-DR positive T cells than 14 with inactive disease (P less than 0.01). Serial examinations showed that the percentages of HLA-DR positive T cells were decreased after therapy in seven with active non-renal or active non-renal and renal diseases but not in one with only active renal disease. A possible significance of T cells expressing EA1 and HLA-DR in the management of patients with SLE is discussed.
Hara
T
T
Department of Paediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Hisano
S
S
Mizuno
Y
Y
Hatae
K
K
Kurokawa
M
M
Ueda
K
K
Sakaguchi
T
T
Umene
M
M
Mizukoshi
M
M
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D013997:Time Factors
D006684:HLA-DR Antigens