Increased stimulatory effect by the combined administration of cocaine and alcohol in mice.
Locomotor activity was recorded after 5-30 mg/kg of cocaine in mice pretreated or not with a stimulant dose of ethanol (2.0 g/kg). The increase in locomotion induced by the association of cocaine plus ethanol was significantly larger when compared to either the group injected with only cocaine or only ethanol.
Masur
J
J
Department of Psicobiologia, Escola Paulista de Medicina, São Paulo, Brazil.
Souza-Formigoni
M L
ML
Pires
M L
ML
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D013268:Stimulation, Chemical
D000431:Ethanol; D003042:Cocaine