Radioresistant tumor cell lines derived from head and neck radiation failures.
We studied the in vitro radiobiological parameters of 16 human head and neck squamous cell carcinoma tumor cell lines cultured from patients who suffered local failure after a curative course of radiotherapy. The radiobiological parameters determined included D0, n, and D. When compared with in vitro radiobiological parameters of tumor cells cultured from head and neck cancer patients prior to radiotherapy, human sarcoma cell lines, and normal human diploid fibroblasts studied in our laboratory (as well as other human tumor cell lines reported in the literature), tumor cells derived from radiotherapy failures on average are resistant to the cytotoxic effects of ionizing radiation.
Weichselbaum
R R
RR
Department of Radiation and Cellular Oncology, Michael Reese Hospital, University of Chicago, Illinois 60637.
Beckett
M A
MA
Vijayakumar
S
S
Ahmed-Swan
S
S
Dritschilo
A
A
Schwartz
J L
JL
Moran
W J
WJ
Goldman
M E
ME
Tybor
A G
AG
Vokes
E E
EE
D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D011836:Radiation Tolerance; D014407:Tumor Cells, Cultured