title: [Clinical efficacy of sulbactam/ampicillin in the field of pediatrics].
abstract: Sulbactam (SBT) is a new derivative of the basic penicillin nucleus. It effectively and irreversibly inhibits several important bacterial beta-lactamases and displays synergistic effects against the resistant organisms when co-administered with ampicillin (ABPC). SBT/ABPC, which is a fixed combination of SBT and ABPC in a 1:2 ratio, was studied for clinical efficacy in the field of pediatrics. Patients treated were infants and children ranging from 12 days to 13 years and 2 months old suffering from acute tonsillitis in 2 cases, acute bronchitis in 2 cases, septicemia in 2 cases, acute enteritis, acute pyelonephritis and osteomyelitis in 1 case each, a total of 9 cases. SBT/ABPC was administered 100-300 mg/kg in daily doses and durations of treatment ranged from 4 to 17 days. Clinical results were "excellent" in 6 and "good" in 2: the efficacy rate was 88.9% or 8 cases out of 9. Neither clinical side effects nor abnormal laboratory findings obviously attributable to SBT/ABPC were observed in any cases.
authors.affiliation: Department of Pediatrics, Kochi Medical School.
authors.forename: H
authors.initials: H
authors.lastname: Ogura
authors.forename: H
authors.initials: H
authors.lastname: Hisakawa
authors.forename: K
authors.initials: K
authors.lastname: Kawakubo
authors.forename: H
authors.initials: H
authors.lastname: Kubota
authors.forename: Y
authors.initials: Y
authors.lastname: Shimanouchi
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Tomoda
authors.forename: Y
authors.initials: Y
authors.lastname: Tone
authors.forename: T
authors.initials: T
authors.lastname: Kurashige
mesh_terms: D000293:Adolescent; D000667:Ampicillin / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D010403:Penicillin Resistance; D013407:Sulbactam / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000667:Ampicillin; D013407:Sulbactam