title: [Atopic dermatitis. I. Characteristics of the clinical course and state of the immune status in relation to the initial level of serum IgE].
abstract: Altogether 97 patients with atopic dermatitis have been examined to follow this relationship, 72 patients presented with disseminated efflorescence, 25 patients with local rash. Measurements of immunoglobulins A, M, G, and D, of the C3c complement components, of the total and allergen-specific IgE C4, inactivators have been carried out, as well as of the total lymphocyte, B lymphocyte, and CD3+, CD4+, and CD8+ lymphocyte subpopulations; the lymphocyte response to ConA mitogenic stimulation has been also under study. The patients with normal and elevated levels of IgE differed by the clinical picture of the disease and by case histories, as well as by the immunity parameters and by the results of zaditen therapy. Cases with very low IgE levels may be indicative of alternative pathogenetic mechanisms.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Sergeev
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Zimin
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Reznikov
authors.forename: V S
authors.initials: VS
authors.lastname: Malyshev
authors.forename: N S
authors.initials: NS
authors.lastname: Pimenova
mesh_terms: D000293:Adolescent; D000328:Adult; D003876:Dermatitis, Atopic / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000032:analysis*; D007665:Ketotifen / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
chemical_list: D007073:Immunoglobulin E; D007665:Ketotifen
vernacular_title: Atopicheskiĭ dermatit. I. Osobennosti klinicheskogo techeniia i sostoianiia immunnogo statusa v zavisimosti ot iskhodnogo urovnia IgE syvorotki.