A second case of neonatal alloimmune thrombocytopenia associated with anti-PlA2 (Zwb) antibodies.
A case of neonatal alloimmune thrombocytopenia due to fetomaternal incompatibility against the platelet specific antigen PlA2 (Zwb) is described. Anti-PlA2 antibodies were present in the maternal serum together with anti-HLA antibodies. Initial identification of the platelet-specific antibodies was achieved by using chloroquine-treated PlA1(+) and PlA1(-) platelets. Antibody specificity was later confirmed using a panel of platelets of known phenotype.
Maslanka
K
K
Institute of Haematology, Warsaw, Poland.
Lucas
G F
GF
Gronkowska
A
A
Davis
J G
JG
Zupanska
B
B
D000328:Adult; D016824:Antigens, Human Platelet; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn / Q000276:immunology*; D039661:Integrin beta3; D007518:Isoantibodies / Q000032:analysis*; D007519:Isoantigens / Q000276:immunology*; D008431:Maternal-Fetal Exchange; D010641:Phenotype; D011247:Pregnancy; D013921:Thrombocytopenia / Q000276:immunology*
D016824:Antigens, Human Platelet; D006680:HLA Antigens; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007518:Isoantibodies; D007519:Isoantigens