Influence of food on relative bioavailability of fluoride in man from Na2FPO3-containing tablets for the treatment of osteoporosis.
Aqueous solutions of NaF and sodium monofluorophosphate (Na2FPO3, MFP) and tablets containing MFP (Caflu, Tridin) were given as single oral doses to fasting healthy volunteers in an intra-individual crossover study. Serum fluoride (F) levels and urinary F concentrations were measured using an F-ion-sensitive electrode; 8 h profiles of F concentrations in serum and 24 h urinary F output were determined. F availability and pharmacokinetic data were identical for all items. In a second group of experiments, the subjects were given Caflu tablets under different experimental regimens: a) on a fasting stomach, b) together with breakfast, c) together with milk, d) together with breakfast and milk. Serum peak levels were reduced when the tablets were taken together with food. Intake together with breakfast did not affect F bioavailability, whereas milk reduced F availability by 28% compared with the fasting stomach experiment. This effect was partly abolished when milk was taken as part of the breakfast. It is suggested that entrapment of F in coagulation products of milk and formation of Ca-salts are important factors causing reduction of F availability, and that prolonged stay of the chyme after concomitant ingestion of food allows F to become liberated from bound forms and coagulation products by digestive processes.
Trautner
K
K
Dental School, University of Würzburg, FRG.
D000328:Adult; D000818:Animals; D001682:Biological Availability; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005502:Food; D006801:Humans; D008297:Male; D008875:Middle Aged; D008892:Milk; D010024:Osteoporosis / Q000188:drug therapy* / Q000378:metabolism; D010710:Phosphates / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013607:Tablets
D010710:Phosphates; D013607:Tablets; C012980:fluorophosphate; D005459:Fluorides