Response to inhibition of androgen action of human ovarian cancer cells in vitro.
The effect of androgens, anti-androgens and epostane on the proliferation of three established human ovarian cancer cell lines was investigated. In one cell line, containing androgen receptors, a dose-dependent inhibitory effect of anti-androgens and epostane was observed. Adaptation of this cell line to flutamide resulted in decreased sensitivity to anti-androgens and epostane. Following adaptation of the cell lines to androgen, androgen receptors were present in all of them and an increased sensitivity to higher concentrations of anti-androgens and epostane was observed. These results suggest that androgens may play a role in the proliferation of ovarian cancer cells, and that these cells may respond to blockage of androgen action or synthesis.
Slotman
B J
BJ
Department of Endocrinology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands.
Rao
B R
BR
D000726:Androgen Antagonists / Q000494:pharmacology*; D000728:Androgens / Q000494:pharmacology; D000737:Androstenols / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D011944:Receptors, Androgen / Q000032:analysis; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000726:Androgen Antagonists; D000728:Androgens; D000737:Androstenols; D011944:Receptors, Androgen; C046855:epostane