title: The safety evaluation of Dunaliella bardawil as a potential food supplement.
abstract: The safety of the alga Dunaliella bardawil for food use, was evaluated in a multigeneration study with rats. Four generations were raised on diets containing 0, 5 or 10% dehydrated D. bardawil. Each experimental group comprised ten males and 20 females. No significant differences were observed between the rats consuming algae and the controls, of any generation, in general appearance, behaviour, growth, reproductive performance or gross pathology. The blood chemistry and haematology of the first generation animals, after 1 yr on the diets, showed no appreciable differences between the experimental and control animals. The only differences in histopathology observed were a decrease in some chronic inflammations and an increased frequency of focal bronchopneumonia in rats fed 10% algae compared with the controls. The latter effect may be attributed to the powdery nature of the algal diet. Considering the large amount of algae consumed by the experimental rats, and the absence of adverse effects in these animals, this multigeneration feeding study may be indicative of the safety of D. bardawil for human consumption.
authors.affiliation: Department of Food Engineering and Biotechnology, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Mokady
authors.forename: A
authors.initials: A
authors.lastname: Abramovici
authors.forename: U
authors.initials: U
authors.lastname: Cogan
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D056890:Eukaryota / Q000032:analysis*; D005260:Female; D005504:Food Analysis; D005527:Food, Fortified; D006304:Health Status; D006403:Hematologic Tests; D008297:Male; D008670:Metals / Q000032:analysis; D008903:Minerals / Q000032:analysis; D009696:Nucleic Acids / Q000032:analysis; D011786:Quality Control; D051381:Rats
chemical_list: D008670:Metals; D008903:Minerals; D009696:Nucleic Acids