In vitro release of gentamicin from beads, an original galenic form, and in vivo efficacy in abdomino-perineal surgery.
The kinetics of the in vitro release of gentamicin by beads, an original galenic form (Gentabilles, Laboratoires Unicet-Unilabo France) was studied for 85 d during which time considerable quantities of antibiotic were released. A very large quantity was released on the 1st d (415 micrograms every 24 h per bead) and overall-there was a considerable time-effect, since on the 85th d, an average of 10 micrograms per 24 h per bead was still being released. The assessment of criteria of bacteriological effectiveness in the use in the in vivo treatment of abdomino-perineal excisions has shown that the MIC of gentamicin determined in relation to isolated organism is much lower than the tissue concentrations. The very low serum concentrations eliminate the possibility of an eventual cochleovestibulary toxicity or renal toxicity. The clinical results, the absence of infectious complications, the shortening of healing time and of duration of hospitalization are in favour of the extended use of this antibiotic prophylaxis in colo-rectal surgery.
Arminot du Chatelet
A M
AM
Laboratoire de Bactériologie et Biologie cellulaire, Université de Montpellier, France.
Fourcade
S
S
Atisso
M A
MA
de Bouchberg
M S
MS
Yakoun
M
M
Varet
A
A
Piedra
C
C
D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D005122:Exudates and Transudates / Q000382:microbiology; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007700:Kinetics; D008297:Male; D008826:Microbial Sensitivity Tests; D008863:Microspheres; D008875:Middle Aged; D010502:Perineum / Q000601:surgery; D011292:Premedication; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*
D005839:Gentamicins