title: Biodegradable microspheres: vaccine delivery system for oral immunization.
abstract: The potential of biocompatible and biodegradable microspheres as a controlled release oral vaccine delivery system has been examined. Orally-administered 1-10 micron microspheres composed of poly (DL-lactide-co-glycolide) were specifically taken up into the Peyer's patch lymphoid tissue of the gut, where those greater than or equal to 5 micron remained for up to 35 days. Microspheres less than 5 micron disseminated within macrophages to the mesenteric lymph nodes and spleen. In contrast to soluble staphylococcal enterotoxin B toxoid, oral immunization with enterotoxoid in microspheres induced circulating toxin-specific antibodies and a concurrent secretory IgA anti-toxin response in saliva and gut fluid.
authors.forename: J H
authors.initials: JH
authors.lastname: Eldridge
authors.forename: R M
authors.initials: RM
authors.lastname: Gilley
authors.forename: J K
authors.initials: JK
authors.lastname: Staas
authors.forename: Z
authors.initials: Z
authors.lastname: Moldoveanu
authors.forename: J A
authors.initials: JA
authors.lastname: Meulbroek
authors.forename: T R
authors.initials: TR
authors.lastname: Tice
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation; D001672:Biocompatible Materials; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D008863:Microspheres; D010581:Peyer's Patches / Q000276:immunology; D014612:Vaccines / Q000008:administration & dosage*
chemical_list: D001672:Biocompatible Materials; D014612:Vaccines