Dose-rate effects of mammary tumor development in female Sprague-Dawley rats exposed to X and gamma radiation.
Mammary tumour development was followed in two experiments involving a total of 2229 female Sprague-Dawley rats exposed to various doses of X or gamma rays at different dose rates. The data for another 462 rats exposed to tritiated water in one of these experiments were also analyzed. The incidence of adenocarcinomas and fibroadenomas at a given time after exposure increased linearly in proportion to total radiation dose for most groups. However, no significant increase in adenocarcinomas was observed with chronic gamma exposures up to 1.1 Gy, and the increase in fibroadenomas observed with chronic gamma exposures at a dose rate of 0.0076 Gy h-1 up to an accumulated dose of 3.3 Gy was small compared to that observed after acute exposures. The incidence of all mammary tumors increased almost linearly with the log of dose rate in the range 0.0076 to 26.3 Gy h-1 for 3 Gy total dose of gamma rays. The effects of X rays appeared to be less influenced by dose rate than were the effects of gamma rays.
Johnson
J R
JR
Chalk River Nuclear Laboratories, Atomic Energy of Canada Limited, Ontario.
Gragtmans
N J
NJ
Myers
D K
DK
Jones
A R
AR
D000230:Adenocarcinoma / Q000209:etiology; D000232:Adenofibroma / Q000209:etiology; D000818:Animals; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D008325:Mammary Neoplasms, Experimental / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium; D014867:Water; D014965:X-Rays
D003037:Cobalt Radioisotopes; D014867:Water; D014316:Tritium