Detection of a novel compound after overdoses of aspirin and amoxapine.
The identification of a novel by-product in the tissue and fluid extracts of a victim of fatal overdoses of the tricyclic antidepressant amoxapine and aspirin is presented. Gas chromatography/mass spectrometry suggested that amoxapine was transacetylated by aspirin to form N-acetylated amoxapine. When standard N-acetylated amoxapine was prepared and subjected to the same analytical testing as extracted tissues and fluids, the metabolite was identified as N-acetylamoxapine. Quantitation of N-acetylamoxapine was obtained by gas chromatography. Concentrations of N-acetylamoxapine compared to those of amoxapine and salicylates in blood, liver, stomach, and small bowel are given.
Osiewicz
R J
RJ
Tidewater Regional Forensic Laboratory, Norfolk, Virginia 23507.
Middleberg
R
R
D000107:Acetylation; D000657:Amoxapine / Q000031:analogs & derivatives / Q000032:analysis* / Q000494:pharmacology / Q000506:poisoning*; D001241:Aspirin / Q000032:analysis / Q000494:pharmacology / Q000506:poisoning*; D001923:Brain Chemistry; D003989:Dibenzoxazepines / Q000032:analysis* / Q000506:poisoning*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000032:analysis; D008099:Liver / Q000032:analysis; D008875:Middle Aged; D013270:Stomach / Q000032:analysis
D003989:Dibenzoxazepines; C060078:N-acetylamoxapine; D001241:Aspirin; D000657:Amoxapine