[Effect of amino acid derivatives of beta-carboline-3-carboxylate on rat behavior].
It was shown, that administration of methyl ether N-(beta-carboline-3-carbonyl)-glycine (GA) at dose level of 1-10 mg/kg markedly reduced exploratory behavior and motor activity in the open field test and facilitated manifestation of different rats defend reaction types. Methyl ether N-(beta-carboline-3-carbonyl)-leucine (LA) at the same doses was less effective. Besides GA (10 mg/kg) like earlier described anxiogenic compound FG 7142 suppressed isolation induced muricide behavior of rats. The results obtained combined with literary data allow us to conclude, that GA possesses expressed anxiogenic activity.
Pliashkevich
Iu G
IuG
Barsegian
G G
GG
Ponomarev
S Iu
SIu
Demushkin
V P
VP
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002243:Carbolines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects
D002243:Carbolines; C057992:glycinamide-beta-carboline-3-carboxylate methyl ester; C057993:leucinamide-beta-carboline-3-carboxylate methyl ester; D007930:Leucine; C036150:beta-carboline-3-carboxylic acid methyl ester; D005998:Glycine
Vliianie aminokislotnykh proizvodnykh beta-karbolin-3-karboksilata na povedenie krys.