[The mechanism of arterial hypertension in prolonged electrostimulation of the emotiogenic zones in the rabbit hypothalamus].
Continuous arterial hypertension which was still present three months after the experiment was achieved by long-term electrostimulation (4 cycles, 12 days each) of the rabbit hypothalamus paraventricular nucleus (PV). Stimulation of the brain subcortical regions was shown to cause excitation in frontal and occipital regions of the cortex and alteration of neurohormonal state, i.e. increase of glucocorticoid content and decrease of both catecholamines, serotonin and histamine blood level in the animals. It is concluded that pathologic functional system resulting in the development of the arterial hypertension is produced on the basis of the generator of pathologically increased excitation (GPIE) in the PV area.
Khomulo
P S
PS
Nikolaev
V I
VI
Sibilev
O P
OP
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000818:Animals; D001794:Blood Pressure; D002395:Catecholamines / Q000097:blood; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004569:Electroencephalography; D004644:Emotions / Q000502:physiology*; D006339:Heart Rate; D006973:Hypertension / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D011817:Rabbits; D013997:Time Factors
D015062:11-Hydroxycorticosteroids; D002395:Catecholamines
Mekhanizm arterial'noĭ gipertenzii pri dlitel'noĭ élektrostimuliatsii émotsiogennykh zon gipotalamusa krolikov.