Sprague Dawley rat mutant with tremor, ataxia, tonic immobility episodes, epilepsy and paralysis.
A spontaneous neurological mutation was detected in a colony of Sprague Dawley rats. The animals developed a progressive neurological syndrome characterized by tremor (which appeared at the age of 1 month), ataxia (at 4 months), immobility episodes (after 5-6 months), audiogenic seizures and hindlimb paralysis (after 10 months). Cross breeding experiments indicate that this is an autosomal recessive mutation, which we have named taiep subline.
Holmgren
B
B
Departamento de Ciencias Fisiológicas, Universidad Autónoma de Puebla, México.
Urbá-Holmgren
R
R
Riboni
L
L
Vega-SaenzdeMiera
E C
EC
D000818:Animals; D001259:Ataxia / Q000662:veterinary; D003433:Crosses, Genetic; D004827:Epilepsy / Q000662:veterinary; D005260:Female; D008297:Male; D009154:Mutation; D009422:Nervous System Diseases / Q000235:genetics / Q000662:veterinary*; D010243:Paralysis / Q000662:veterinary; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D011922:Rats, Mutant Strains; D012376:Rodent Diseases / Q000235:genetics*; D013577:Syndrome / Q000662:veterinary; D014202:Tremor / Q000662:veterinary