New aspects in mechanisms of antihypoxic piracetam action.
A long-term piracetam treatment leads to an improved stimulus-effect-coupling of potassium stimulated dopamine release: The maximum effect of the potassium stimulus is already obtained in presence of much lower Ca++-concentrations (Ca++-economizing effect) than normally. In consequence of the improved stimulus-effect-coupling by piracetam treatment the dose-dependent inhibitory effect of the calcium antagonist flunarizine on the fractional efflux rate of dopamine is decreased. The volume of vesicular structures is not involved in the piracetam effect.
Wustmann
C
C
Institute of Pharmacology and Toxicology, Medical Academy Carl Gustav Carus, Dresden, DDR.
Fischer
H D
HD
Rudolph
E
E
Schmidt
J
J
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005444:Flunarizine / Q000494:pharmacology; D000860:Hypoxia / Q000517:prevention & control; D066298:In Vitro Techniques; D007700:Kinetics; D010889:Piracetam / Q000494:pharmacology* / Q000627:therapeutic use; D011188:Potassium / Q000494:pharmacology; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012110:Reserpine / Q000494:pharmacology
D011760:Pyrrolidinones; D012110:Reserpine; D005444:Flunarizine; D011188:Potassium; D004298:Dopamine; D010889:Piracetam