Neuromuscular blockade with magnesium sulfate and nifedipine.
A patient who received tocolysis with nifedipine developed neuromuscular blockade after 500 mg of magnesium sulfate was administered. This reaction demonstrates that nifedipine can seriously potentiate the toxicity of magnesium. Caution should be exercised when these two tocolytics are combined.
Snyder
S W
SW
Department of Obstetrics and Gynecology, University of Missouri Health Sciences Center, Columbia 65212.
Cardwell
M S
MS
D000328:Adult; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000009:adverse effects* / Q000494:pharmacology; D009468:Neuromuscular Diseases / Q000139:chemically induced*; D009469:Neuromuscular Junction / Q000187:drug effects; D009543:Nifedipine / Q000009:adverse effects*; D011247:Pregnancy; D015145:Tocolysis
D008278:Magnesium Sulfate; D009543:Nifedipine