title: Comparison of the dissolution behaviour of tablets containing the drug in a polyethyleneglycol solid dispersion with direct compressed tablets.
abstract: Higher dissolution rates of diazepam were noted with tablets containing the drug in polyethyleneglycol solid dispersion compared to these containing a physical mixture of the drug granulated with polyethyleneglycol or to directly compressed tablets. The shape factor and t63% depend strongly on the method of incorporation of the drug in the compressed mass. The dissolution of the drug becomes pH independent when it is present as a solid dispersion, which may be advantageous for the bioavailability.
authors.forename: R
authors.initials: R
authors.lastname: Kinget
mesh_terms: D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D011092:Polyethylene Glycols; D012995:Solubility; D013607:Tablets
chemical_list: D013607:Tablets; D011092:Polyethylene Glycols