title: Determination of the efficacy of pyrantel pamoate at the therapeutic dose rate against the tapeworm Anoplocephala perfoliata in equids using a modification of the critical test method.
abstract: A total of 59 equids (54 horses and five Shetland ponies) were treated with pyrantel pamoate once, at the dose rate of approximately 6.6 mg base kg-1, during the period November 1985-January 1988. The drug was administered as a paste formulation (51 equids) intraorally or as a suspension formulation by stomach tube (eight equids). The purpose of treatment was to evaluate the activity of pyrantel pamoate (at the therapeutic dose rate) for removal of the tapeworm, Anoplocephala perfoliata, by a modified (24-h) critical test. The presence or absence of tapeworms was not determined for the equids before treatment. Twenty-three (39%) of the 59 treated equids were found to be infected with A. perfoliata (from one to 180 specimens per infected equid) at necropsy. Removals varied from 67 to 100% (average 88%) for the 18 infected equids treated with the paste formulation. For the five infected equids treated with the suspension, removals were 58-100% (average 75%). The combined average removal of A. perfoliata for both formulations was 87%. Two abnormal (triradiate) specimens of A. perfoliata were recovered; one from each of two different equids.
authors.affiliation: Department of Veterinary Science, College of Agriculture, University of Kentucky, Gluck Equine Research Center, Lexington 40546-0099.
authors.forename: E T
authors.initials: ET
authors.lastname: Lyons
authors.forename: J H
authors.initials: JH
authors.lastname: Drudge
authors.forename: S C
authors.initials: SC
authors.lastname: Tolliver
authors.forename: T W
authors.initials: TW
authors.lastname: Swerczek
authors.forename: S S
authors.initials: SS
authors.lastname: Collins
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002589:Cestoda / Q000187:drug effects; D002590:Cestode Infections / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D008297:Male; D009824:Ointments; D011715:Pyrantel / Q000031:analogs & derivatives*; D011716:Pyrantel Pamoate / Q000008:administration & dosage / Q000627:therapeutic use*; D013535:Suspensions
chemical_list: D009824:Ointments; D013535:Suspensions; D011715:Pyrantel; D011716:Pyrantel Pamoate