title: Analysis of historical control litter parameters of reproduction toxicity studies in Sprague-Dawley derived rats.
abstract: Control litter data from reproduction toxicity studies in SD derived rats bred in our closed colony were investigated for historical changes, differences due to study design or generations, seasonal variations and effects of vehicle-treatment. The litter size did not change visibly during the entire 16-year period, but the number of live fetuses differed significantly between study designs or generations. The fetal weight gradually increased during these years. The malformation rate decreased, while the rate of 14 th ribs remained stable. There were no seasonal variations and no effects of vehicle-treatment.
authors.affiliation: Department of Experimental Pathology, Nippon Boehringer Ingelheim Co. Ltd., Hyogo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: A
authors.initials: A
authors.lastname: Kast
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D001835:Body Weight; D000013:Congenital Abnormalities; D005260:Female; D008098:Litter Size; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*; D012098:Reproduction; D012621:Seasons; D012996:Solutions
chemical_list: D012996:Solutions