title: Effect of a new fluorinated quinolone (ofloxacin) on the chemiluminescence of phagocytosing human neutrophils.
abstract: We measured the chemiluminescence (CL) of human neutrophils (PMNLs) exposed to different concentrations of ofloxacin (2, 4, and 6 micrograms/ml) readily achievable in therapy. CL reaction during zymosan phagocytosis by PMNLs obtained from human healthy volunteers was registered in a computer-linked LKB 1251 luminometer. Ofloxacin did not induce significant variations on the respiratory burst of PMNLs.
authors.affiliation: Chair of Infectious Diseases, University of Florence, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Aquilini
authors.forename: A
authors.initials: A
authors.lastname: Bartoloni
authors.forename: F
authors.initials: F
authors.lastname: Paradisi
mesh_terms: D006801:Humans; D008163:Luminescent Measurements; D009504:Neutrophils / Q000276:immunology*; D015242:Ofloxacin / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*
chemical_list: D015242:Ofloxacin