title: Danger of central pontine myelinolysis in hypotonic dehydration and recommendation for treatment.
abstract: Isotonic saline is the fluid most commonly used for treatment of asymptomatic hypotonic dehydration, but as shown in the case presented in this article, rapid increase in serum sodium may follow administration of isotonic saline, leading to the development of central pontine myelinolysis (CPM). Because the necessity of rapid correction is less, whereas the risk of CPM is greater with chronic asymptomatic hyponatremia than with acute hyponatremia, use of a half normal saline might be more appropriate than normal saline for treating certain patients with hypotonic dehydration with asymptomatic hyponatremia. The calculations indicate that half normal saline will expand the extracellular volume quite effectively, but the rate of increase in serum sodium will be considerably slower than that with normal saline.
authors.affiliation: Department of Medicine, State University of New York, Health Science Center, Brooklyn 11203.
authors.forename: M S
authors.initials: MS
authors.lastname: Oh
authors.forename: J
authors.initials: J
authors.lastname: Uribarri
authors.forename: D
authors.initials: D
authors.lastname: Barrido
authors.forename: E
authors.initials: E
authors.lastname: Landman
authors.forename: K C
authors.initials: KC
authors.lastname: Choi
authors.forename: H J
authors.initials: HJ
authors.lastname: Carroll
mesh_terms: D003681:Dehydration / Q000150:complications* / Q000188:drug therapy; D003711:Demyelinating Diseases / Q000209:etiology*; D006801:Humans; D007038:Hypotonic Solutions; D007552:Isotonic Solutions; D008297:Male; D008875:Middle Aged; D009123:Muscle Hypotonia / Q000150:complications* / Q000188:drug therapy; D011149:Pons; D012307:Risk Factors; D012965:Sodium Chloride / Q000627:therapeutic use
chemical_list: D007038:Hypotonic Solutions; D007552:Isotonic Solutions; D012965:Sodium Chloride