title: ["Sister Joseph's module"--umbilical metastases of internal tumors].
abstract: A 50-year-old man, who was otherwise asymptomatic, presented with an umbilical metastasis of a pancreatic adenocarcinoma. Umbilical metastases ("Sister Joseph's nodule") of internal malignancies are rare. Although they may be the first sign of the underlying malignancy, their appearance is generally correlated with a poor prognosis. Among approximately 400 cases reported in the literature, the most frequent primary tumors were carcinomas of the stomach, ovary, large intestine and pancreas.
authors.affiliation: Dermatologische Universitätsklinik Ulm.
authors.forename: G
authors.initials: G
authors.lastname: Holzki
authors.forename: R
authors.initials: R
authors.lastname: Kaufmann
authors.forename: L
authors.initials: L
authors.lastname: Weber
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000556:secondary*; D014057:Tomography, X-Ray Computed; D014472:Umbilicus / Q000473:pathology*
vernacular_title: "Sister Joseph's nodule"--Nabelmetastasen interner Tumoren.