Lithocholate in liver tissue with obstructive jaundice.
The existence of tissue-bound lithocholate in liver tissue was first suggested by Nair et al. (Lipids 1988;12:922-929). Since lithocholate is well known to be cholestatic, we investigated whether tissue-bound lithocholate, if present, can be correlated to liver dysfunction in obstructive jaundice. Tissue-bound lithocholate in liver tissues of 7 patients with obstructive jaundice was analyzed using gas chromatography-mass spectrometry-selected ion monitoring. We found no accumulation of lithocholate, including tissue-bound form, indicating that the role of lithocholate in inducing hepatic dysfunction in obstructive jaundice is minimal, if any.
Yanagisawa
J
J
First Department of Surgery, Kyushu University Faculty of Medicine, Fukuoka, Japan.
Nagai
M
M
Hirano
Y
Y
Fujii
T
T
Nakayama
F
F
D002779:Cholestasis / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008095:Lithocholic Acid / Q000032:analysis*; D008099:Liver / Q000032:analysis*
D008095:Lithocholic Acid