title: Ethanol-induced changes in lipid peroxidation and glutathione content in rat brain.
abstract: The effect of acute and chronic ethanol administration on brain lipid peroxide and glutathione levels was investigated in rats. Acute ethanol administration (5 g/kg, i.p.) led to an increase in lipid peroxide levels and a decrease in glutathione levels in whole brain homogenates without cerebellum. However, there was no change in brain lipid peroxide and glutathione levels of rats chronically treated with ethanol.
authors.affiliation: Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Uysal
authors.forename: G
authors.initials: G
authors.lastname: Kutalp
authors.forename: G
authors.initials: G
authors.lastname: Ozdemirler
authors.forename: G
authors.initials: G
authors.lastname: Aykaç
mesh_terms: D000435:Alcoholic Intoxication / Q000473:pathology; D000437:Alcoholism / Q000473:pathology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D000431:Ethanol / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000431:Ethanol; D008315:Malondialdehyde; D005978:Glutathione