[Effect of dopamine on lidocaine metabolism in patients after partial liver resection--a pharmacokinetic analysis].
Pharmacokinetic changes in plasma lidocaine after bolus injection (1mg.kg-1) with or without dopamine infusion (3 micrograms.kg-1.min-1) were studied on patients who had a partial resection of the liver under enflurane-nitrous oxide anesthesia. Dopamine infusion was started in 10 minutes after endotracheal intubation. Serum concentrations of lidocaine and MEGX were measured by HPLC. The areas under the plasma lidocaine time-concentration curves were calculated after the administration of the drug into the peripheral vein or portal vein. The liver's extraction rate of lidocaine was evaluated by an equation based on the areas under the two time-concentration curve. The average extraction rate in the group with dopamine infusion was significantly higher than that in the group without dopamine. No significant difference was found in the ratio of AUC of MEGX to that of lidocaine between the group to which dopamine was administered and the control group.
Takata
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D004298:Dopamine / Q000494:pharmacology*; D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism / Q000601:surgery*
D008012:Lidocaine; C001173:monoethylglycinexylidide; D004298:Dopamine