title: Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease.
abstract: Monoamine oxidase A and B (MAO A and B) are the central enzymes that catalyze oxidative deamination of biogenic amines throughout the body. The regional locations of genes encoding MAO A and B on the X chromosome were determined by using full-length cDNA clones for human MAO A and B, respectively. Using somatic cell hybrids, in situ hybridization, and field-inversion gel electrophoresis as well as deletion mapping in a patient with Norrie disease, we concluded that these two genes are close to each other and to the DXS7 locus (Xp 11.3).
authors.affiliation: Division of Biological Sciences, School of Pharmacy, University of Southern California, Los Angeles 90033.
authors.forename: N C
authors.initials: NC
authors.lastname: Lan
authors.forename: C
authors.initials: C
authors.lastname: Heinzmann
authors.forename: A
authors.initials: A
authors.lastname: Gal
authors.forename: I
authors.initials: I
authors.lastname: Klisak
authors.forename: U
authors.initials: U
authors.lastname: Orth
authors.forename: E
authors.initials: E
authors.lastname: Lai
authors.forename: J
authors.initials: J
authors.lastname: Grimsby
authors.forename: R S
authors.initials: RS
authors.lastname: Sparkes
authors.forename: T
authors.initials: T
authors.lastname: Mohandas
authors.forename: J C
authors.initials: JC
authors.lastname: Shih
mesh_terms: D000818:Animals; D001766:Blindness / Q000201:enzymology / Q000235:genetics*; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000235:genetics*; D015183:Restriction Mapping; D012160:Retina / Q000002:abnormalities*; D014960:X Chromosome
chemical_list: D004247:DNA; D008995:Monoamine Oxidase