Synthesis and CVS activity of 1-(2,3, 2,5, 2,6 dichlorophenyl)-3-morpholinophenyl-5-substituted benzylidene-thiobarbituric acids (3-17).
Fifteen new thiobarbituric acids have been prepared by the Knoevenagel condensation of appropriate aldehydes with 1-(2,3, 2,5, 2,6 dichlorophenyl)-3-morpholinophenyl thiobarbituric acids. Five compounds of this series were found to be biphasic in nature whereas some compounds showed appreciable hypotensive activity of varying magnitude and duration.
Singh
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Department of Chemistry, University of Lucknow, India.
Misra
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VS
D000818:Animals; D001597:Benzylidene Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D002317:Cardiovascular Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D009025:Morpholines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013858:Thiobarbiturates / Q000138:chemical synthesis / Q000494:pharmacology*
D001597:Benzylidene Compounds; D002317:Cardiovascular Agents; D009025:Morpholines; D013858:Thiobarbiturates