[Absorption of C14-labeled dye "active red 5CX"++ immobilized on polysaccharides in the rat gastrointestinal tract].
Rats were maintained on a diet containing 14C-aniline procion dye "active red 5CX" either in a hydrolyzed or chemically immobilized form on starch and cellulose. Absorption of the label, distribution in tissues and excretion were studied within 6-48 hrs. Independently on the forms of the preparation used more than 80% of the label occurred in blood and were then excreted with urine. Molecule of the azo-dye appears to degrade in large intestine by means of microflora with splitting of the azo-bond and the potentially toxic metabolites developed penetrated into a body media. Immobilization of the dye on polymers, including cellulose was not an effective approach to prevent these reactions.
Shatrov
G N
GN
Gmoshinskiĭ
I V
IV
Zaĭtsev
A N
AN
D000818:Animals; D001391:Azo Compounds / Q000493:pharmacokinetics*; D002250:Carbon Radioisotopes; D004396:Coloring Agents / Q000493:pharmacokinetics*; D004064:Digestive System / Q000378:metabolism*; D007408:Intestinal Absorption; D008297:Male; D011134:Polysaccharides; D051381:Rats; D011919:Rats, Inbred Strains
D001391:Azo Compounds; D002250:Carbon Radioisotopes; D004396:Coloring Agents; D011134:Polysaccharides; C059093:brilliant red 5SKH
Vsasyvanie mechennogo 14C krasitelia "aktivnyĭ krasnyĭ 5CX", immobilizovannogo na polisakharidakh, v zheludochno- kishechnom trakte krys.