Unique inheritance of streptomycin-induced deafness.
Analysis of reported families which include two or more members with streptomycin-induced hearing loss reveals that the trait of high susceptibility of cochlea to streptomycin is transmitted primarily through females. This is not explained by ordinary Mendelian inheritance; rather it is best understood by extranuclear inheritance.
Higashi
K
K
Department of Otolaryngology, School of Medicine, Akita University, Japan.
D003051:Cochlea / Q000187:drug effects; D003638:Deafness / Q000139:chemically induced / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D012737:Sex Factors; D013307:Streptomycin / Q000009:adverse effects*
D013307:Streptomycin