Vitamin K absorption capacity and its association with vitamin K deficiency.
We measured plasma vitamin K concentrations in 194 5-day-old infants three hours after administration of a 4-mg dose of vitamin K (menaquinone-4, Kaytwo syrup, Eisai Co Ltd, Tokyo, Japan). We investigated association with other factors contributing to vitamin K deficiency. These plasma vitamin K concentrations varied greatly among the neonates from values below the limit of detection (2 ng/mL) to more than 1000 ng/mL. The vitamin K concentration was associated with nutritive vitamin K deficiency represented by plasma protein induced by vitamin K absence or antagonist-II (PIVKA-II) values. The wide variation in vitamin K absorption is considered to be one of the major causative factors in infantile vitamin K deficiency.
Shinzawa
T
T
Department of Pediatrics, Tottori University School of Medicine, Yonago, Japan.
Mura
T
T
Tsunei
M
M
Shiraki
K
K
D000284:Administration, Oral; D001647:Bile Acids and Salts / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008895:Milk, Human / Q000032:analysis; D013997:Time Factors; D014812:Vitamin K / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism*; D014813:Vitamin K Deficiency / Q000209:etiology*; D006475:Vitamin K Deficiency Bleeding / Q000209:etiology
D001647:Bile Acids and Salts; D014812:Vitamin K