Gyrase inhibitor ciprofloxacin in human parotid saliva.
The excretion of ciprofloxacin (Ciprobay) via the human parotid gland was investigated. 2 h after an intravenous bolus injection (200 mg ciprofloxacin) mean serum concentrations of 0.43 mg/l were achieved, and these decreased within 6 h after injection to 0.17 mg/l. The concentrations of the gyrase inhibitor in parotid saliva showed a close positive correlation to the serum levels (r = 0.96), but they were significantly lower than serum levels. They decreased from 0.1 mg/l 2 h after injection to 0.04 mg/l after 6 h.
Adler
D
D
Dept. of Otorhinolaryngology, University of Heidelberg, FRG.
Maier
H
H
D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D006801:Humans; D010306:Parotid Gland / Q000378:metabolism*; D012463:Saliva / Q000032:analysis*
D002939:Ciprofloxacin