Effect of Ca2+ entry blockers on myosin light-chain kinase and protein kinase C.
Thirteen Ca2+ entry blockers were compared with respect to their inhibitory effects on the activity of smooth muscle myosin light-chain kinase and smooth muscle protein kinase C, and the Ca2+-induced contraction of basilar artery rings. Comparison of the IC50 values obtained for these compounds, suggests that with the exception of ferdiline inhibition of the enzymes does not contribute to vascular smooth muscle relaxation.
Schächtele
C
C
Gödecke Research Institute, Department of Pharmacology, Freiburg, F.R.G.
Wagner
B
B
Rudolph
C
C
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002147:Calmodulin / Q000378:metabolism; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D009219:Myosin-Light-Chain Kinase / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D011817:Rabbits
D002121:Calcium Channel Blockers; D002147:Calmodulin; D011493:Protein Kinase C; D009219:Myosin-Light-Chain Kinase