title: Abnormalities in myocardial segmental wall motion during lumbar epidural anesthesia.
abstract: The effect of lumbar epidural anesthesia on myocardial wall motion was compared in two groups of patients using precordial two-dimensional echocardiography (2DE). All patients were scheduled to undergo lower abdominal or peripheral surgery. Group 1 included five healthy ASA PS 1 subjects and group 2 included 10 patients with coronary artery disease (CAD). In all patients 12.5 ml of 2% lidocaine HCl was injected into the lumbar epidural space, and systolic and diastolic blood pressures, and heart rate were continuously monitored. 2DE evaluation was performed before and at 10, 20, 30, and 60 min (T10-T60) after epidural lidocaine injection. The left ventricular wall was divided into 16 segments for parasternal long-axis, short-axis and apical four-chamber views. The wall motion of each segment was graded on a scale from 1 (dyskinesia) to 6 (hyperkinesia), with 5 representing normal motion. A decrease in segmental wall motion greater than or equal to 2 grades was considered indicative of ischemia. Plasma lidocaine and catecholamine levels were measured before and 10, 20, and 60 min after epidural lidocaine injection. Peak plasma lidocaine levels in groups 1 and 2 were 2.79 +/- 1.06 micrograms/ml (mean +/- SD) and 2.58 +/- 1.48 micrograms/ml at 10 min, respectively (NS). Plasma epinephrine and norepinephrine levels were unchanged from baseline. Systolic pressures decreased significantly in group 2 from T10 to T60. Diastolic pressure decreased significantly in the same group from T20 to T60, and in group 1 only at T10. Mean arterial pressure decreased significantly in both groups at T30, without change in heart rate.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Departement d'Anesthesie-Reanimation n*2, Hopital Henri Mondor, Creteil, France.
authors.forename: M
authors.initials: M
authors.lastname: Saada
authors.forename: A M
authors.initials: AM
authors.lastname: Duval
authors.forename: F
authors.initials: F
authors.lastname: Bonnet
authors.forename: B
authors.initials: B
authors.lastname: Rey
authors.forename: G
authors.initials: G
authors.lastname: Castillon
authors.forename: I
authors.initials: I
authors.lastname: Macquin-Mavier
authors.forename: R
authors.initials: R
authors.lastname: Cabrit
authors.forename: O
authors.initials: O
authors.lastname: Boico
authors.forename: A
authors.initials: A
authors.lastname: Castaigne
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000767:Anesthesia, Epidural; D003327:Coronary Disease / Q000097:blood / Q000503:physiopathology*; D015150:Echocardiography, Doppler; D004837:Epinephrine / Q000097:blood; D005260:Female; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics; D006801:Humans; D008012:Lidocaine / Q000097:blood / Q000494:pharmacology; D008161:Lumbosacral Region; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood
chemical_list: D008012:Lidocaine; D009638:Norepinephrine; D004837:Epinephrine