[Lipid metabolism and peripheral hemodynamics in arteriosclerosis obliterans treated with nifedipine--a comparison with pentoxifylline].
In the present study altogether 51 patients with obliterating arteriosclerosis stage II according to Fontaine were examined concerning the haemodynamic and lipid parameters under influence of nifedipine and pentoxifylline, respectively. An antiatherogenic effect under nifedipine takes place possibly by the diminution of the triglycerides in the serum and the blood pressure as well as by the increase of the linolenic acid in the serum (precursor of the vasoprotective prostacyclin I3). Pentoxifylline essentially behaves lipid-neutral. The increase of the intermittent claudication distance clearly speaks for pentoxifylline. - Nifedipine should only be used in concomitant indications.
Beykirch
H
H
Klinik für Innere Medizin, Karl-Marx-Universität Leipzig.
Reuter
W
W
Voigt
H
H
Herrmann
W
W
D001162:Arteriosclerosis Obliterans / Q000097:blood / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007511:Ischemia / Q000188:drug therapy; D007866:Leg / Q000098:blood supply; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D010431:Pentoxifylline / Q000627:therapeutic use*; D013805:Theobromine / Q000031:analogs & derivatives*
D008055:Lipids; D009543:Nifedipine; D013805:Theobromine; D010431:Pentoxifylline
Lipidstoffwechsel und periphere Hämodynamik bei Arteriosclerosis obliterans unter Nifedipin--ein Vergleich gegen Pentoxifyllin.