Fractionation and antitumor activity of the water-insoluble residue of Agaricus blazei fruiting bodies.
Some polysaccharide-containing materials were successively extracted from the fruiting bodies of Agaricus blazei with aqueous ammonium oxalate and sodium hydroxide, fractionated, and assayed for antitumor activity. From chemical analyses and n.m.r. data, it was concluded that the most active fraction, FIII-2-b, was comprised of protein and a (1----6)-beta-D-glucan.
Kawagishi
H
H
Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University, Japan.
Inagaki
R
R
Kanao
T
T
Mizuno
T
T
Shimura
K
K
Ito
H
H
Hagiwara
T
T
Nakamura
T
T
D000363:Agaricales / Q000032:analysis*; D000364:Agaricus / Q000032:analysis*; D000596:Amino Acids / Q000032:analysis; D002241:Carbohydrates / Q000032:analysis; D005936:Glucans / Q000032:analysis; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010070:Oxalates; D011134:Polysaccharides / Q000302:isolation & purification* / Q000627:therapeutic use; D012972:Sodium Hydroxide; D012995:Solubility; D014867:Water
D000596:Amino Acids; D002241:Carbohydrates; D005936:Glucans; D010070:Oxalates; D011134:Polysaccharides; D014867:Water; D012972:Sodium Hydroxide