title: Influence of buthionine sulfoximine on the lethality of ifosfamide and ifosfamide-induced urotoxicity in mice.
abstract: Buthionine sulfoximine (500 mg/kg, i.p.), a glutathione-depleting agent, was found to increase the acute lethal toxicity and urotoxicity induced by ifosfamide in mice.
authors.affiliation: Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takayanagi
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D019328:Buthionine Sulfoximine; D003543:Cysteamine / Q000633:toxicity; D005978:Glutathione / Q000378:metabolism; D007069:Ifosfamide / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives* / Q000633:toxicity; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects; D014570:Urologic Diseases / Q000139:chemically induced*
chemical_list: D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D003543:Cysteamine; D005978:Glutathione; D007069:Ifosfamide