Immunological state of adult germfree miniature Minnesota pigs.
Fundamental hematological and immunological data were obtained on sexually mature germfree miniature pigs fed, after the milk diet period, with cereal-type diet sterilized by gamma-radiation, and were compared with data of control conventional animals. Germfree adult pigs had a lower count of peripheral blood leukocytes with a lower percentage of neutrophil granulocytes and without any younger forms, a lower total serum protein level with a negligible amount of gamma and alpha 2 globulin fractions and a higher serum albumin and beta globulin level. In the mesenteric lymph nodes and in spleen, surface IgA-bearing cells predominated over surface IgG-bearing cells. Also a large amount of IgA-containing cells was found in the intestinal lamina propria, where the IgG cells were present in a negligible amount. IgM cells were the most frequent surface isotype in peripheral blood. The count of blood T lymphocytes was more than doubled.
Trávnícek
J
J
Department of Gnotobiology, Czechoslovak Academy of Sciences, Prague.
Mandel
L
L
Trebichavský
I
I
Talafantová
M
M
D000818:Animals; D005260:Female; D005856:Germ-Free Life; D006098:Granulocytes / Q000276:immunology; D007107:Immune System / Q000502:physiology*; D007136:Immunoglobulins / Q000097:blood / Q000502:physiology; D007962:Leukocytes / Q000276:immunology; D008297:Male; D013552:Swine; D013556:Swine, Miniature / Q000276:immunology*
D007136:Immunoglobulins