Two types of mammosomatotropes in mouse adenohypophysis.
Two types of mammosomatotropes (MS), the small-granule and vesicle-granule MS, were detected in mouse adenohypophysis by electron microscopy and immunohistochemistry. Both cell-types were immunoreactive to prolactin (PRL) and growth hormone (GH) antisera. The small-granule MS contained small, round, solid secretory granules about 100 nm in diameter, and were smaller than the classical GH and PRL cell-types. The vesicle-granule MS contained secretory granules like cored vesicles, and were larger than classical GH and PRL cells. Small-granule MS were immunoreactive to both PRL and GH antisera in the same region of the cell cytoplasm; the vesicle-granule MS, however, were immunoreactive to only PRL antiserum in most cytoplasmic areas, and a positive response to both PRL and GH antisera was confined to only certain small areas.
Sasaki
F
F
Department of Veterinary Anatomy, College of Agriculture, University of Osaka Prefecture, Sakai, Japan.
Iwama
Y
Y
D000818:Animals; D013006:Growth Hormone / Q000378:metabolism*; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D010903:Pituitary Gland, Anterior / Q000166:cytology* / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*
D011388:Prolactin; D013006:Growth Hormone