The antiarrhythmic activity of N-alkyl-1,2-diphenylethanolamines.
The activity of N-alkyl-1,2-diphenylethanolamines against CaCl2-induced cardiac arrhythmia was evaluated in the rat. The potencies of the compounds were compared with that of the established calcium ion-channel blocker, verapamil. The N-methyl, N-ethyl, and N-isobutyl derivatives as well as verapamil at doses of 2-8 mumols kg-1 protected the animals against the induced arrhythmia. The potency order was verapamil greater than N methyl greater than N-ethyl greater than N-isobutyl derivatives. The N-isopropyl and N-butyl derivatives were inactive. The antiarrhythmic activity of the compounds was not due to local anesthetic activity but may be caused by calcium-channel inhibition.
el Tahir
K E
KE
Department of Pharmacology, College of Pharmacy, King Saud University, Saudi Arabia.
al-Obeid
H A
HA
al-Rashood
K A
KA
Madani
A A
AA
Ageel
A M
AM
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004983:Ethanolamines / Q000494:pharmacology*; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D004983:Ethanolamines; D008012:Lidocaine; D014700:Verapamil