[Further research on the role of prostanoids in controlling renal function in humans in normal potassium balance and acute experimental potassium depletion. I: Studies of normal potassium balance. Effects of indomethacin].
The renal function was studied by clearance (cl.) method during hypotonic polyuria (oral water load followed by 5% dextrose solution infusion) and successive relative antidiuresis induced by lysine-8-vasopressin (LVP) administration (5 microU in bolo followed by continuous infusion at a rate of 0.04 microU/min). Four 15 min and two 60 min clearance (cl.) periods were performed during hypotonic polyuria and antidiuresis, respectively. Glomerular filtration rate was estimated by creatinine cl.; the osmotic cl. (Cosm, CH2O), the absolute and fractional excretions of water, sodium, potassium and chloride were determined by usual methods. The urinary PGE2, 6-keto-PGF1 alpha and TxB2 concentrations were determined by RIA method. Fourteen healthy women submitted to a normal sodium and potassium daily intake were studied; in 6 of them paired studies in absence and in presence of indomethacin (100 mg, i.m.), respectively, were performed. LVP induced a significant reduction of creatinine cl., urinary flow rate and of prostanoid excretion. In hypotonic polyuria, indomethacin significantly reduced the creatinine cl. and the diuretic response to the water load; moreover the urinary PGE2 and 6-keto-PGF1 alpha excretions were significantly lower (85.6 +/- 1.9% and 37.7 +/- 3.2%) while the reduction of urinary TxB2 excretion was not significant (34.4 +/- 13%). Indomethacin did not affect significantly the LVP renal effects in normal potassium balance.
Agnoli
G C
GC
Borgatti
R
R
Cacciari
M
M
Dorigoni
S
S
Garutti
C
C
Ikonomu
E
E
Lenzi
P
P
Marinelli
M
M
D015232:Dinoprostone / Q000652:urine; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D011188:Potassium / Q000378:metabolism; D011191:Potassium Deficiency / Q000378:metabolism*; D011453:Prostaglandins / Q000502:physiology*; D014882:Water-Electrolyte Balance
D011453:Prostaglandins; D015232:Dinoprostone; D011188:Potassium; D007213:Indomethacin
Ulteriori richerche sul ruolo dei prostanoidi nel controllo della funzione renale nell'uomo in bilancio potassico normale e in deplezione potassica acuta sperimentale. I: Studi in bilancio potassico normale. Effetti dell'indometacina.