The oral hypoglycemic activity of 2,5-dioxamide derivatives of 1,3,4-thiadiazole.
Dioxamide derivatives of 1,3,4-thiadiazole, synthesized earlier by Oke (1986), were screened for hypoglycemic activity. Alloxan-induced diabetic albino rats were used in the study. The structure-activity relationship of the dioxamide derivatives of 1,3,4-thiadiazole is discussed. The study shows that the dioxamide derivatives of 1,3,4-thiadiazole are more potent and of longer duration of action when compared with the oxamide derivatives of 1,3,4-thiadiazole, which were previously reported by Oke and Cherynk (1981).
Oke
J M
JM
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, College of Medicine, University of Ibadan, Nigeria.
Olowookorun
M O
MO
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002747:Chlorpropamide / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D004149:Dioxoles / Q000494:pharmacology*; D005260:Female; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000494:pharmacology*
D001786:Blood Glucose; D004149:Dioxoles; D007004:Hypoglycemic Agents; D013830:Thiadiazoles; D002747:Chlorpropamide