title: [Biotransformation of 5-phenyl-1,3,4-benzotriazepines].
abstract: After administration of three 2-aminosubstituted 5-phenyl-1,3,4-benzotriazepines with hypoglycemic effects to rats 10 metabolites were isolated from urine and feces besides traces of the unchanged drugs. N-Dealkylation, aromatic hydroxylation, N-acetylation and ring contraction by hydrolytic processes beginning in the stomach occurred. The main excretion route is with the feces.
authors.affiliation: Sektion Chemie, Humboldt-Universität zu Berlin.
authors.forename: S
authors.initials: S
authors.lastname: Pfeifer
authors.forename: C
authors.initials: C
authors.lastname: Niepel
authors.forename: P
authors.initials: P
authors.lastname: Franke
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000493:pharmacokinetics* / Q000652:urine; D001711:Biotransformation; D005243:Feces / Q000032:analysis; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001552:Benzazepines; D007004:Hypoglycemic Agents
vernacular_title: Biotransformation von 5-Phenyl-1,3,4-benzotriazepinen.