Effects of clozapine on ketamine-induced linguopharyngeal events in rats.
We tested the effects of clozapine (0.02-20 mg/kg i.p.) on ketamine-induced linguopharyngeal events in rats anesthetized with i.m. injections of ketamine hydrochloride (100 mg/kg) and mounted on a stereotaxic with the tip of the tongue tied to a force displacement transducer monitoring tongue protrusions, retrusions and swallows. Reduction began at the 0.04 mg/kg dose. At 4.8 mg/kg there was total suppression of events. At 20 mg/kg, suppression lasted for 1 h. Notably clozapine doses causing total suppression of events in our model were much lower than those usually reported to alter dopamine turnover.
Marco
L A
LA
Department of Psychiatry, College of Medicine, University of South Alabama, Mobile 36617.
Joshi
R S
RS
Brigham
T E
TE
Aldes
L D
LD
Chronister
R B
RB
D000818:Animals; D003024:Clozapine / Q000494:pharmacology*; D003679:Deglutition / Q000187:drug effects*; D003984:Dibenzazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007649:Ketamine / Q000494:pharmacology*; D010614:Pharynx / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014059:Tongue / Q000187:drug effects / Q000502:physiology*
D003984:Dibenzazepines; D007649:Ketamine; D003024:Clozapine