[Dependence of the antitumor activity of nitroso alkyl urea derivatives on their chemical structure].
The antitumour activity of 10 analogs of nitroso alkyl urea was studied on 6 tumour strains. It was shown that antitumour effect depends upon the gentle structural changes of substances (changes of side chain, the position of aromatic nucleus in it, as well as the nature, quantity and position of substitutes in the nucleus). 7 compounds out of 10 analogs of nitroso alkyl urea have manifested antitumour activity.
Sharashidze
L K
LK
Turkiia
N G
NG
Lagidze
D R
DR
Adamiia
I K
IK
Asatiani
V V
VV
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D051381:Rats; D012074:Remission Induction; D013329:Structure-Activity Relationship; D013997:Time Factors
D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds
Zavisimost' protivoopukholevoĭ aktivnosti nekotorykh proizvodnykh nitrozoalkilmocheviny ot khimicheskoĭ struktury.