Neurotoxicity and lethality of toxic extracts from Atlantic coast shellfish.
1. HCl-extract of poisonous shellfish was injected i.p. into Swiss-Webster mice. 2. Behavioral effects (sluggishness, scratching, huddling, clonic convulsions, respiratory distress and mortality) were noted. 3. Infant mice were more sensitive than were the adults to XTRT toxicity. Estimated LD50 values were; adult: 34.8 ml/kg i.p., infant: 9.6 ml/kg i.p. 4. The mouse model of shellfish-toxicity offers the advantages of a degree of similarity with the human clinical situation and a rapid time course for screening antagonists against shellfish poisoning.
Bose
R
R
Department of Pharmacology, University of Manitoba, Winnipeg, Canada.
Glavin
G B
GB
Pinsky
C
C
D000375:Aging; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009498:Neurotoxins / Q000633:toxicity*; D012758:Shellfish / Q000633:toxicity*; D014020:Tissue Extracts / Q000633:toxicity
D009498:Neurotoxins; D014020:Tissue Extracts