Ethanol-induced changes in lipid peroxidation and glutathione content in rat brain.
The effect of acute and chronic ethanol administration on brain lipid peroxide and glutathione levels was investigated in rats. Acute ethanol administration (5 g/kg, i.p.) led to an increase in lipid peroxide levels and a decrease in glutathione levels in whole brain homogenates without cerebellum. However, there was no change in brain lipid peroxide and glutathione levels of rats chronically treated with ethanol.
Uysal
M
M
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
Kutalp
G
G
Ozdemirler
G
G
Aykaç
G
G
D000435:Alcoholic Intoxication / Q000473:pathology; D000437:Alcoholism / Q000473:pathology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D000431:Ethanol / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol; D008315:Malondialdehyde; D005978:Glutathione