title: Intravenous administration of isosorbide dinitrate attenuates the pressor response to laryngoscopy and tracheal intubation.
abstract: In order to evaluate the effect of isosorbide dinitrate (ISDN), administered as a bolus intravenous injection, on the circulatory response to tracheal intubation, mean arterial pressure (MAP), and heart rate (HR) in response to laryngoscopy for 30 s followed by tracheal intubation were compared in patients not receiving ISDN (control) and receiving 40 micrograms/kg or 80 micrograms/kg of ISDN 45 s before starting laryngoscopy. Each group consisted of 10 patients undergoing elective surgery. Forty-five seconds after starting laryngoscopy, MAP was significantly (P less than 0.01) lower in patients receiving 80 micrograms/kg ISDN than in those receiving no or 40 micrograms/kg ISDN. HR increased to a similar extent in the three groups. These results indicate that a bolus injection of ISDN (80 micrograms/kg) is a simple, practical and highly effective means of attenuating the hypertensive response to direct laryngoscopy and tracheal intubation.
authors.affiliation: Department of Anesthesia, Kyoto University Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hatano
authors.forename: R
authors.initials: R
authors.lastname: Imai
authors.forename: K
authors.initials: K
authors.lastname: Komatsu
authors.forename: K
authors.initials: K
authors.lastname: Mori
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D007442:Intubation, Intratracheal; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000627:therapeutic use*; D007828:Laryngoscopy; D008297:Male; D013997:Time Factors; D014666:Vasomotor System / Q000187:drug effects
chemical_list: D007548:Isosorbide Dinitrate