[Effect of cytostatic and hormonal drugs on the phagocytic activity of neutrophils of leukemia patients].
Based on the data concerned with blood cells from 12 normal persons and 18 patients with acute leukemia, the action of the clinically applied cytostatics and hormonal drugs (6-mercaptopurine, cytarabine, vincristine, rubomycin) on granulocyte functions was investigated in vitro and in vivo (in patients). The respective characteristics were found to be in a good enough agreement, enabling the prediction of the effect of polychemotherapy on granulocyte functions (the digestion capacity). It has been established that each of the drugs under study changes the characteristics of granulocytes to a different degree. The individual sensitivity of the digestion capacity of phagocytes to the drugs under study does not depend on the disease pattern or initial characteristics of the phagocytic activity of the cells.
Rozanova
O E
OE
Serova
L D
LD
Shabalin
V N
VN
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*
D000970:Antineoplastic Agents; D006728:Hormones
Vliianie tsitostaticheskikh i gormonal'nykh preparatov na fagotsitarnuiu aktivnost' neĭtrofilov bol'nykh leĭkozom.