title: Antifertility principle of Ruta graveolens.
abstract: Chloroform extracts of the root, stem and leaf of Ruta graveolens L. showed significant anti-fertility activity in rats when administered intragastrically on days 1-10 post-coitum. Fractionation of the extracts led to the isolation of chalepensin as the active component with some toxicity. Time-dosing experiments demonstrated that chalepensin acts at the early stages of pregnancy. It is not clear at this stage if the anti-fertility effect is a direct manifestation of chalepensin toxicity.
authors.forename: Y C
authors.initials: YC
authors.lastname: Kong
authors.forename: C P
authors.initials: CP
authors.lastname: Lau
authors.forename: K H
authors.initials: KH
authors.lastname: Wat
authors.forename: K H
authors.initials: KH
authors.lastname: Ng
authors.forename: P P
authors.initials: PP
authors.lastname: But
authors.forename: K F
authors.initials: KF
authors.lastname: Cheng
authors.forename: P G
authors.initials: PG
authors.lastname: Waterman
mesh_terms: D000078223:5-Methoxypsoralen; D000818:Animals; D003281:Contraceptives, Postcoital / Q000302:isolation & purification; D011564:Furocoumarins / Q000302:isolation & purification / Q000494:pharmacology*; D008730:Methoxsalen / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003281:Contraceptives, Postcoital; D011564:Furocoumarins; C020740:3-(alpha,alpha-dimethylallyl)psoralen; D000078223:5-Methoxypsoralen; D008730:Methoxsalen