title: [Immunohistochemical localization of laminin and its relation to the grade of histological malignancy in oral cancer].
abstract: The immunohistochemical localization of Laminin has been investigated with a monoclonal antibody in biopsy specimens from 27 patients with an invasive squamous cell carcinoma of the oral cavity. In normal mucosa, laminin was found distributed in a linear pattern in the epithelial-stromal junction, around the blood vessels, the nerve fibres, and the skeletal muscle bundles. In the cancerous tissues a variety in the linear staining around the cancer cell nests was seen. Extreme attenuation or complete loss of the linear staining of laminin was demonstrated in 8/27 specimens, and these tumors histologically showed a high grade of malignancy with H.E. staining.
authors.affiliation: Dept. of Oral Surgery, Sapporo Medical College.
authors.forename: M
authors.initials: M
authors.lastname: Noguchi
authors.forename: G
authors.initials: G
authors.lastname: Kohama
authors.forename: H
authors.initials: H
authors.lastname: Hiratsuka
authors.forename: A
authors.initials: A
authors.lastname: Miyakawa
authors.forename: A
authors.initials: A
authors.lastname: Yamaguchi
authors.forename: I
authors.initials: I
authors.lastname: Nagai
authors.forename: J
authors.initials: J
authors.lastname: Kyogoku
authors.forename: T
authors.initials: T
authors.lastname: Odajima
mesh_terms: D001485:Basement Membrane / Q000032:analysis / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000032:analysis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000032:analysis*; D009061:Mouth Mucosa / Q000032:analysis / Q000473:pathology; D009062:Mouth Neoplasms / Q000032:analysis* / Q000473:pathology; D009361:Neoplasm Invasiveness
chemical_list: D007797:Laminin