title: Chromosomal aberrations induced by low-dose gamma-irradiation. Study of R-banded chromosomes of human lymphocytes.
abstract: The effect of low-dose (0-0.5 Gy) gamma-radiations was studied on R-banded chromosomes from lymphocytes of healthy donors of various ages. In cells from newborns, an increase of chromosome damage roughly proportional to the dose was found. In lymphocytes from young adults chromosomal aberrations were not detected at doses of 0.05 and 0.1 Gy, and in lymphocytes from old adults chromosomal aberrations were not detected at doses of 0.05 and 0.1 Gy, and in lymphocytes from old adults not even at 0.2 Gy. The difficulty in detecting aberrations in lymphocytes from adults is largely due to a considerable background of chromosomal anomalies which should be borne in mind in dosimetry studies. The rate of induction largely depends on the types of rearrangements. One-break terminal deletions are efficiently induced at 0.1 and 0.2 Gy and are the best indicators of exposure at these doses. At 0.5 Gy, the frequencies of 2-break lesions, i.e., dicentrics and reciprocal translocations, increase, whereas that of deletions decreases.
authors.affiliation: U.R.A. 620 C.N.R.S., Institut Curie, Section de Biologie, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Lefrançois
authors.forename: W
authors.initials: W
authors.lastname: al Achkar
authors.forename: A
authors.initials: A
authors.lastname: Aurias
authors.forename: J
authors.initials: J
authors.lastname: Couturier
authors.forename: A M
authors.initials: AM
authors.lastname: Dutrillaux
authors.forename: B
authors.initials: B
authors.lastname: Dutrillaux
authors.forename: A
authors.initials: A
authors.lastname: Flüry-Herard
authors.forename: M
authors.initials: M
authors.lastname: Gerbault-Seureau
authors.forename: F
authors.initials: F
authors.lastname: Hoffschir
authors.forename: E
authors.initials: E
authors.lastname: Lamoliatte
mesh_terms: D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion / Q000528:radiation effects; D002875:Chromosomes / Q000528:radiation effects*; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000528:radiation effects*; D014178:Translocation, Genetic / Q000528:radiation effects