Acute pancreatitis and bile duct lesions in rat induced by dibutyltin dichloride.
After i.v. or i.p. administration of a single dose of dibutyltin dichloride (DBTC) the following changes were observed in pancreas and bile ducts of male rats: acute interstitial pancreatitis, enlargement of diameter and destruction of epithelial cells of the bile ducts, increase of serum alkaline phosphatase activity. The effects were dependent on the dose of DBTC (1, 4 or 6 mg/kg body weight), the route of administration and the time after treatment. The pancreatitis induced by DBTC is under further investigation as a model of experimental pancreatitis.
Merkord
J
J
Institute of Pharmacology and Toxicology, Wilhelm Pieck University of Rostock, GDR.
Hennighausen
G
G
D000208:Acute Disease; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001652:Bile Ducts / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009947:Organotin Compounds / Q000633:toxicity*; D010179:Pancreas / Q000187:drug effects / Q000473:pathology*; D010195:Pancreatitis / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains
D009947:Organotin Compounds; D000469:Alkaline Phosphatase; C020735:dibutyldichlorotin