[Effect of cyclosporin on tumor xenotransplantation under the renal capsule in mice].
Stimulating effect of cyclosporine on growth and invasiveness of tumor xenographts was studied on a model of rat solid sarcoma M-1 transplanted under the kidney capsule in mice. Cyclosporine was administered subcutaneously in a dose of 25 or 75 mg/kg on days 1-7. The stimulating effect of cyclosporine was directly associated with the immunodepressant dose and accompanied by a decrease in the thymus weight. With using cyclosporine the model of xenographts under the kidney capsule can be of value in screening cytostatics and immunomodulators.
Viadro
M M
MM
Terent'eva
T G
TG
Fomina
I P
IP
Ivanitskaia
L P
LP
Bibikova
M V
MV
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology*; D005260:Female; D006085:Graft Survival / Q000187:drug effects; D006133:Growth Substances; D007668:Kidney / Q000601:surgery*; D007680:Kidney Neoplasms / Q000473:pathology*; D051379:Mice; D009368:Neoplasm Transplantation; D051381:Rats; D012513:Sarcoma, Experimental / Q000473:pathology / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000601:surgery*; D013268:Stimulation, Chemical; D013997:Time Factors; D014183:Transplantation, Heterologous
D003524:Cyclosporins; D006133:Growth Substances
Effekt tsiklosporina na ksenotransplantatsiiu opukholeĭ pod kapsulu pochki u mysheĭ.