Effect of amogastrin on the release of various prostaglandins into gastric lumen in man.
The effect of amogastrin on the release of 5 types of prostaglandins (PGs) [PGE2, 6-keto-PGF1 alpha, PGF2 alpha, PGD2, and thromboxan B2 (TXB2)] into the gastric lumen was evaluated in seven healthy volunteers. Gastric juice was obtained under basal and amogastrin-stimulated conditions. The 5 types of PGs in the gastric juice were separated by high-performance liquid chromatography and then measured by radioimmunoassay. PGE2 was the major component in gastric juices among the PGs measured in this study. The release of 5 types of PGs increased after amogastrin administration. The rate of increase was high for PGE2 and 6-keto-PGF1 alpha (3.48 and 3.98 respectively), whereas it was low for PGD2 (1.54). It is suggested that endogenously synthesized PGs, especially PGE2 and PGI2 (assayed as 6-keto-PGF1 alpha), play important roles in the gastric mucosal protection and the regulation of acid secretion.
Saitoh
O
O
Second Department of Internal Medicine, Osaka Medical College, Japan.
Tei
H
H
Okumura
Y
Y
Asada
S
S
Hirata
I
I
Ohshiba
S
S
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000328:Adult; D015237:Dinoprost / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000494:pharmacology*; D006801:Humans; D008297:Male; D015230:Prostaglandin D2 / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism*; D013758:Tetragastrin / Q000031:analogs & derivatives / Q000494:pharmacology*; D013929:Thromboxane B2 / Q000378:metabolism
D005755:Gastrins; D011453:Prostaglandins; D013758:Tetragastrin; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; C035656:amogastrin; D015237:Dinoprost; D015232:Dinoprostone; D015230:Prostaglandin D2