title: Sprague Dawley rat mutant with tremor, ataxia, tonic immobility episodes, epilepsy and paralysis.
abstract: A spontaneous neurological mutation was detected in a colony of Sprague Dawley rats. The animals developed a progressive neurological syndrome characterized by tremor (which appeared at the age of 1 month), ataxia (at 4 months), immobility episodes (after 5-6 months), audiogenic seizures and hindlimb paralysis (after 10 months). Cross breeding experiments indicate that this is an autosomal recessive mutation, which we have named taiep subline.
authors.affiliation: Departamento de Ciencias Fisiológicas, Universidad Autónoma de Puebla, México.
authors.forename: B
authors.initials: B
authors.lastname: Holmgren
authors.forename: R
authors.initials: R
authors.lastname: Urbá-Holmgren
authors.forename: L
authors.initials: L
authors.lastname: Riboni
authors.forename: E C
authors.initials: EC
authors.lastname: Vega-SaenzdeMiera
mesh_terms: D000818:Animals; D001259:Ataxia / Q000662:veterinary; D003433:Crosses, Genetic; D004827:Epilepsy / Q000662:veterinary; D005260:Female; D008297:Male; D009154:Mutation; D009422:Nervous System Diseases / Q000235:genetics / Q000662:veterinary*; D010243:Paralysis / Q000662:veterinary; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D011922:Rats, Mutant Strains; D012376:Rodent Diseases / Q000235:genetics*; D013577:Syndrome / Q000662:veterinary; D014202:Tremor / Q000662:veterinary