[Effect of ethanol on N-nitrososarcosine ethyl ester-induced carcinogenesis in the esophageal and forestomach mucosa of mongrel rats].
Administration of N-nitrososarcosine ethyl ether (50 mg/kg, per os, every day during 4 months) to rats induced after 8 months multiple tumours (most often papillomas) of oesophagus and forestomach. Total incidence of tumour-bearing animals was 42.4% in oesophagus and 21.2% in forestomach, distribution of tumours being 85.6 and 14.4%, respectively. The combined administration of carcinogen with 40% water solution of ethanol (0.5 ml, per os, every day during 8 months) did not change general incidence and multiplicity of all tumours, but decreased the relative incidence of oesophagus tumours and increased that of forestomach tumours. Possible mechanisms of organotropism shifts are discussed.
Novikov
A I
AI
Aleksandrov
V A
VA
Zabezhinskiĭ
M A
MA
Stoliarov
V I
VI
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D003043:Cocarcinogenesis; D004347:Drug Interactions; D004938:Esophageal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D004947:Esophagus / Q000187:drug effects / Q000473:pathology; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D008297:Male; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D009602:Nitrosamines / Q000633:toxicity*; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens; D009602:Nitrosamines; C028099:N-nitrososarcosine ethyl ester; D000431:Ethanol
Vliianie étanola na kantserogenez, indutsirovannyĭ étilovym éfirom N-nitrozosarkozina v slizistoĭ obolochke pishchevoda i predzheludka nelineĭnykh krys.