Effect of acute treatment of mice with L-histidine on the brain levels of amino acids.
The brain histidine level in mice dose-dependently increased 1 and 2 hr after an i.p. injection of 0.5-1.5 g/kg of L-histidine. The treatment with 1.0 and 1.5 g/kg but not 0.5 g/kg of L-histidine significantly decreased the brain levels of tyrosine, phenylalanine and some other amino acids 1 hr later. A complete recovery or a rebound rise of amino acid levels was observed 2 hr after treatment. These results indicate that there is a change in the transport of amino acids into the brain after treatment with large doses of L-histidine.
Oishi
R
R
Department of Pharmacology, Okayama University Medical School, Japan.
Furuno
K
K
Gomita
Y
Y
Araki
Y
Y
Saeki
K
K
D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006639:Histidine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D013997:Time Factors
D000596:Amino Acids; D006639:Histidine