Extramedullary blast crisis and hemolytic anemia in a patient with t(3p+;4q-) and rapidly evolving myelogenous leukemia.
We have reported the case of a patient with a rapidly evolving myelogenous leukemia associated with hemolytic anemia, extramedullary evolution, and an isolated translocation of the long arm of chromosome 4 to the short arm of chromosome 3. The hemolytic process was primarily extravascular and was not associated with pyruvate kinase or glucose-6-phosphate dehydrogenase deficiency. Although blasts were absent from the peripheral smear and represented less than 10% of the bone marrow myeloid precursors, multiple organs including the heart, liver, lungs, and spleen were infiltrated with blasts at autopsy.
Carr
M E
ME
Department of Medicine, Medical College of Virginia, Richmond.
Todd
W M
WM
D000743:Anemia, Hemolytic / Q000150:complications*; D001752:Blast Crisis / Q000150:complications / Q000473:pathology; D002869:Chromosome Aberrations / Q000150:complications*; D025063:Chromosome Disorders; D002893:Chromosomes, Human, Pair 3; D002894:Chromosomes, Human, Pair 4; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D007621:Karyotyping; D015465:Leukemia, Myeloid, Accelerated Phase / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic