title: EMOP/CA chemotherapy for the treatment of aggressive non-Hodgkin's lymphomas.
abstract: From October 1983 to June 1987, 32 patients with aggressive non-Hodgkin's lymphomas (diffuse centroblastic, lymphoblastic and Burkitt type) were treated with the weekly alternating EMOP/CA schedule, total duration 12 weeks. There were six bulky stage II, nine stage III and 17 stage IV patients, median age 54 years (range 19-75). The complete remission rate was 59% (95% confidence limits 40-76%) and the partial remission rate 28% providing an overall response rate of 87%. With a median follow up time of 33 months (range 18-56) the relapse-free survival of those patients achieving a complete remission is 52% and the overall survival for the 32 patients treated is 27%. The CR rate for patients with stage IV disease was 47% and for those with stage II and III disease was 73% of whom 81% remain in remission. EMOP/CA chemotherapy produces acceptable results in stage II and III aggressive non-Hodgkin's lymphomas but is inadequate therapy for stage IV disease.
authors.affiliation: Department of Medical Oncology, Charing Cross Hospital, London, U.K.
authors.forename: D B
authors.initials: DB
authors.lastname: Smith
authors.forename: J A
authors.initials: JA
authors.lastname: Ledermann
authors.forename: E
authors.initials: E
authors.lastname: Boesen
authors.forename: E S
authors.initials: ES
authors.lastname: Newlands
authors.forename: R H
authors.initials: RH
authors.lastname: Begent
authors.forename: G J
authors.initials: GJ
authors.lastname: Rustin
authors.forename: M G
authors.initials: MG
authors.lastname: Glaser
authors.forename: K D
authors.initials: KD
authors.lastname: Bagshawe
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009367:Neoplasm Staging; D011239:Prednisolone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D008727:Methotrexate