title: The influence of ofloxacin versus trimethoprim-sulfamethoxazole on the aerobic flora in granulocytopenic subjects.
abstract: Ofloxacin (300 mg twice a day) and trimethoprim-sulfamethoxazole (TMP-SMZ) (160 mg trimethoprim and 800 mg sulfamethoxazole twice a day) were given prophylactically to 19 adult patients with acute leukemia undergoing induction chemotherapy. The influence of the two regimens on the bacterial aerobic flora was evaluated. Both of the prophylactic regimens conditioned the aerobic microflora of the patients. Both groups acquired new microorganisms, prevalently gram-positive cocci, but also gram-negative bacteria with the TMP-SMZ regimen. Both treatment groups acquired yeasts.
authors.affiliation: Cattedra di Malattie Infettive, Università di Firenze, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bartoloni
authors.forename: R
authors.initials: R
authors.lastname: Fanci
authors.forename: A
authors.initials: A
authors.lastname: Orsi
authors.forename: D
authors.initials: D
authors.lastname: Aquilini
authors.forename: A
authors.initials: A
authors.lastname: Bosi
authors.forename: P
authors.initials: P
authors.lastname: Rossi Ferrini
authors.forename: F
authors.initials: F
authors.lastname: Paradisi
mesh_terms: D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000382:microbiology*; D001420:Bacteria, Aerobic / Q000187:drug effects*; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000494:pharmacology*; D011897:Random Allocation; D013419:Sulfamethizole / Q000494:pharmacology*; D013432:Sulfathiazoles / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*; D000096926:Benzenesulfonamides
chemical_list: D004338:Drug Combinations; D015242:Ofloxacin; D013419:Sulfamethizole; D013432:Sulfathiazoles; D014295:Trimethoprim; C029078:trimethoprim sulfamethizole; D000096926:Benzenesulfonamides