Linkage analysis with inbreeding.
For computational reasons, linkage analysis of highly inbred pedigrees is often performed under the assumption that spouse pairs are genetically unrelated. A formulation of the likelihood of a pedigree which takes into account all of the genealogical information omega, for an arbitrary relationship between a pair of spouses, is proposed. Lod scores at a recombination fraction of 0 for an inbred three-member nuclear family are presented.
Van Eerdewegh
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Department of Psychiatry, Washington University, St. Louis, MO.
D002648:Child; D003198:Computer Simulation; D003241:Consanguinity; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D010375:Pedigree