title: Variations in the in vivo P-31 MR spectra of the developing human brain during postnatal life. Work in progress.
abstract: With use of a modified surface coil technique, the authors recorded phosphorus-31 magnetic resonance (MR) spectra of the brains of 40 neonates and infants (48 examinations) ranging from 33 weeks postconceptional age to 6 years of age. Signals of phosphorus metabolites were collected in the frontotemporal region of the brain, and various P-31 MR spectral variables were compared at different times during postnatal life. The ratio of the phosphomonoester signal to the phosphodiester signal, which is related to phospholipid synthesis, decreases within the first 6 months of life; during the same time period, the ratio of the phosphocreatine (PCr) signal to the beta-adenosine triphosphate (ATP) signal increases. In addition, a difference was observed between the areas under the alpha- and beta-ATP peaks. This difference increases with age and correlates with the PCr/beta-ATP signal ratio. The variation of the alpha-ATP peak with age might be explained by overlap of the signals of nicotinamide adenine dinucleotide (NAD) and alpha-ATP.
authors.affiliation: MR Unit, University Children's Hospital, Zurich.
authors.forename: C
authors.initials: C
authors.lastname: Boesch
authors.forename: R
authors.initials: R
authors.lastname: Gruetter
authors.forename: E
authors.initials: E
authors.lastname: Martin
authors.forename: G
authors.initials: G
authors.lastname: Duc
authors.forename: K
authors.initials: K
authors.lastname: Wüthrich
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009682:Magnetic Resonance Spectroscopy; D010725:Phosphocreatine / Q000378:metabolism
chemical_list: D010725:Phosphocreatine; D000255:Adenosine Triphosphate