title: Ion mobility spectrometry of halothane, enflurane, and isoflurane anesthetics in air and respired gases.
abstract: Three common gaseous anesthetics, halothane, enflurane, and isoflurane, were characterized by using ion mobility spectrometry (IMS)/mass spectrometry, and the dependence of product ion distributions on temperature and concentration was evaluated. At 40 degrees C and 500 ppb, negative ion mobility spectra in air largely consisted of monomer or dimer adducts with Br- or Cl- formed through dissociative electron capture of molecular neutrals. With increased temperature or decreased vapor concentrations, declustering and dissociation of product ions became pronounced. Ion-molecule reactions in the drift region of the IMS were evident as distortions in peak shape in the mass-resolved mobility spectra and in variable reduced mobilities for the same ions. A portable hand-held IMS was used for convenient, real-time detection of enflurane in respired gases following a controlled inhalation episode.
authors.forename: G A
authors.initials: GA
authors.lastname: Eiceman
authors.forename: D B
authors.initials: DB
authors.lastname: Shoff
authors.forename: C S
authors.initials: CS
authors.lastname: Harden
authors.forename: A P
authors.initials: AP
authors.lastname: Snyder
authors.forename: P M
authors.initials: PM
authors.lastname: Martinez
authors.forename: M E
authors.initials: ME
authors.lastname: Fleischer
authors.forename: M L
authors.initials: ML
authors.lastname: Watkins
mesh_terms: D000388:Air / Q000032:analysis*; D000777:Anesthetics / Q000032:analysis*; D004737:Enflurane / Q000032:analysis*; D006221:Halothane / Q000032:analysis*; D006801:Humans; D007530:Isoflurane / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods; D012119:Respiration; D013696:Temperature
chemical_list: D000777:Anesthetics; D004737:Enflurane; D007530:Isoflurane; D006221:Halothane