title: Diclazuril, a new broad spectrum anticoccidial drug in chickens. 2. Battery trials.
abstract: Battery trials have confirmed the broad spectrum anticoccidial activity of diclazuril as previously reported in dose titration studies. The advocated dose level of 1 ppm in the diet demonstrated excellent activity against the economically most important Eimeria species. At this dose level, body weight gains were comparable to those of uninfected, unmedicated controls and the oocyst production was negative in most species. Lesion scores and dropping scores were nil or highly reduced. An E. maxima-147 strain, less sensitive to ionophores, also responded well to diclazuril. It was concluded that diclazuril is a promising anticoccidial for the control of all species of coccidia that cause losses to the poultry industry.
authors.affiliation: Janssen Pharmaceutica, Beerse, Belgium.
authors.forename: O
authors.initials: O
authors.lastname: Vanparijs
authors.forename: R
authors.initials: R
authors.lastname: Marsboom
authors.forename: L
authors.initials: L
authors.lastname: Hermans
authors.forename: L
authors.initials: L
authors.lastname: Van der Flaes
mesh_terms: D000818:Animals; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000627:therapeutic use*; D008297:Male; D009570:Nitriles / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000188:drug therapy*; D014227:Triazines / Q000627:therapeutic use*; D015430:Weight Gain
chemical_list: D003049:Coccidiostats; D009570:Nitriles; D014227:Triazines; C057884:diclazuril