Antimicrobial and cytotoxic activity of rottlerin-type compounds from Hypericum drummondii.
Hexane extracts of Hypericum drummondii showed significant activity against the Gram-positive bacteria Staphylococcus aureus, Bacillus subtilis, and the acid-fast bacterium Mycobacterium smegmatis in an agar well diffusion assay. Employing bioassay-directed fractionation procedures, four new rottlerin-type compounds (drummondins A, B, C[1-3], and F [4]) were isolated and identified by spectral and physical characterization. The antimicrobial activity of these compounds was comparable to or greater than that demonstrated by streptomycin and generally correlated with cytotoxic activity determined with cultured P-388, KB, or human cancer cell lines (breast, colon, lung, melanoma). No cell-type selectivity was observed. In addition, two known compounds, albaspidins A-A [5] and P-P [6], were isolated and structured characterized. Neither demonstrated appreciable antimicrobial or cytotoxic activity.
Jayasuriya
H
H
Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University 38677.
McChesney
J D
JD
Swanson
S M
SM
Pezzuto
J M
JM
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010944:Plants / Q000032:analysis*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans