title: Blood conservation in cardiac surgery. Preliminary results with an institutional commitment.
abstract: To evaluate the effect of blood conservation in cardiac surgery, use of blood products was analyzed in patients undergoing CABG before and after implementation of blood conservation techniques. Age, sex, coronary anatomy, ejection fraction, cardiopulmonary bypass time, and the preoperative hematocrit, platelet count, and clotting studies were similar in both groups. Methods of blood conservation included autologous transfusion of blood withdrawn before bypass, autotransfusion of shed mediastinal blood, strict protocols for transfusion, and acceptance of normovolemic anemia. With blood conservation, 25.5% of patients received no transfusions and 54.9% received blood only. Significant reductions (p less than 0.001) were achieved in the transfusion of blood from 6.8 +/- 2.4 to 2.3 +/- 2.6 units per patient and of plasma from 2.5 +/- 2.2 to 0.6 +/- 2.0 units per patient. Reductions in the use of platelets and cryoprecipitate were substantial, although not significant. Total donor exposure was reduced significantly from 13.1 +/- 7.3 to 4.3 +/- 6.7 donors per patient. The postoperative hematocrit was significantly lower and remained so at discharge. However, 30 days later there was no difference. This reduction in transfusion requirements decreased costs and donor exposure.
authors.affiliation: Department of Surgery, Veterans Administration Medical Center, Durham, North Carolina.
authors.forename: G S
authors.initials: GS
authors.lastname: Tyson
authors.forename: R N
authors.initials: RN
authors.lastname: Sladen
authors.forename: V
authors.initials: V
authors.lastname: Spainhour
authors.forename: M A
authors.initials: MA
authors.lastname: Savitt
authors.forename: T B
authors.initials: TB
authors.lastname: Ferguson
authors.forename: W G
authors.initials: WG
authors.lastname: Wolfe
mesh_terms: D000368:Aged; D001793:Blood Preservation / Q000379:methods*; D001803:Blood Transfusion / Q000379:methods*; D001804:Blood Transfusion, Autologous; D006348:Cardiac Surgical Procedures; D002985:Clinical Protocols; D005112:Extracorporeal Circulation / Q000379:methods; D005440:Fluid Therapy / Q000379:methods; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies