[Value of trimetazidine in the long-term treatment of cardiomyopathies of ischemic origin].
The effect of a cellular anti-ischemic, trimetazidine (TMZ) in ischemic cardiomyopathies, was evaluated in a double-blind versus-placebo (P) trial, over a period of six months. 20 patients, mean age: 59.5 years, with advanced ischemic cardiomyopathy, demonstrated by left catheterization and coronary angiography, with a past history of myocardial infarction, received either 60 mg per day of TMZ (nine patients) or the placebo (eleven patients) in addition to a basic treatment of digitalis, diuretics and nitrated medications. A complete, clinical, biological and paraclinical evaluation, including chest X-ray, ultrasonography, isotopic ventriculography and 24 h-ECG, was performed upon inclusion in the study; and after three and six months of treatment. Two patients from the placebo group were not reevaluated at six months. The clinical condition, according to the NYHA classification, improved in all patients from the TMZ group, deteriorated in eight on nine patients from the placebo group (p less than 0.001). The isotopic stroke volume is preserved with TMZ, deteriorated with P. The cardiac volume decreases with TMZ, increasing with P. TMZ is beneficial clinically and functionally in advanced ischemic cardiomyopathies.
Brottier
L
L
Service de Cardiologie, Hôpital Cardiologique du Haut-Lévéque, Pessac.
Barat
J L
JL
Combe
C
C
Boussens
B
B
Bonnet
J
J
Bricaud
H
H
D000704:Analysis of Variance; D002306:Cardiac Volume / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D010919:Placebos; D013318:Stroke Volume / Q000187:drug effects; D014292:Trimetazidine / Q000494:pharmacology / Q000627:therapeutic use*
D010879:Piperazines; D010919:Placebos; D014292:Trimetazidine
Intérêt de la trimétazidine dans le traitement au long cours des myocardiopathies d'origine ischémique.