title: [The antipyrine test in occupational medicine research--evaluation of individual reproducibility and frequency distribution of half-life].
abstract: The antipyrine half-life is a reliable index of biotransformation capacity of the liver. The half-lives were estimated in 137 subjects; the result was a logarithmic normal distribution of these parameters. Therefore our patients were subdivided into groups of so-called fast, intermediate and slow metabolisers (fast: t50 less than 7.6 h and slow: t50 greater than 14.9 h). Under conditions given here the intraindividual coefficient of variation was about 11.5%. The antipyrine elimination curves were calculated by a computer programme and the values were analysed statistically.
authors.forename: H
authors.initials: H
authors.lastname: Uhlig
authors.forename: J
authors.initials: J
authors.lastname: Damrau
authors.forename: R
authors.initials: R
authors.lastname: Skölziger
mesh_terms: D000328:Adult; D000983:Antipyrine / Q000493:pharmacokinetics; D005260:Female; D006207:Half-Life; D006801:Humans; D008658:Inactivation, Metabolic; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged
chemical_list: D000983:Antipyrine
vernacular_title: Der Antipyrin-Test in der arbeitsmedizinischen Forschung--Bewertung der individuellen Reproduzierbarkeit und der Häufigkeitsverteilung der Halbwertszeit.