Pseudoscleroderma secondary to phytonadione (vitamin K1) injections.
Two patients showed symmetrical sclerodermoid (morphea-like) skin lesions at sites of intramuscular phytonadione (vitamin K1) injections. The lesions appeared one and two years after the injections. A dense sclerosis involving the reticular dermis and subcutaneous fat was observed on histologic examination of biopsy specimens. Local adverse reactions to phytonadione are reviewed. Possible causative mechanisms for phytonadione-induced pseudoscleroderma are discussed.
Pujol
R M
RM
Department of Dermatology, Hospital de Sant Pau, Barcelona, Spain.
Puig
L
L
Moreno
A
A
Pérez
M
M
de Moragas
J M
JM
D000368:Aged; D001706:Biopsy; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology; D010837:Vitamin K 1 / Q000009:adverse effects*
D010837:Vitamin K 1