title: Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22.
abstract: We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).
authors.affiliation: Dipartimento di Medicina e Oncologia Sperimentale, Universita' di Torino, Italy.
authors.forename: A P
authors.initials: AP
authors.lastname: Palumbo
authors.forename: M
authors.initials: M
authors.lastname: Boccadoro
authors.forename: S
authors.initials: S
authors.lastname: Battaglio
authors.forename: P
authors.initials: P
authors.lastname: Corradini
authors.forename: B
authors.initials: B
authors.lastname: Giovinazzo
authors.forename: G
authors.initials: G
authors.lastname: Avanzi
authors.forename: G
authors.initials: G
authors.lastname: Ponzio
mesh_terms: D000328:Adult; D015139:Blotting, Southern; D002884:Chromosomes, Human, Pair 15; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D007621:Karyotyping; D010677:Philadelphia Chromosome; D013920:Thrombocythemia, Essential / Q000235:genetics*; D014178:Translocation, Genetic