title: [A study of ivermectin in the treatment of lymphatic filariasis due to Wuchereria bancrofti var. pacifica in French Polynesia].
abstract: Forty carriers of 20 or more W. bancrofti var. pacifica per ml were blind administered ivermectin at 50, 100, 150 or 200 mcg/kg doses. The rate of successful treatment was 100% with the 4 dosages. The percentage cure rate and the decrease percentage in the microfilarial count were significantly higher in persons treated with 100, 150 and 200 mcg/kg than in persons treated with 50 mcg/kg. Frequency and intensity of side-reactions were similar to those observed during treatment with DEC; they were more frequent and severe in persons with greatest microfilaremia but did not depend on the dosage. Ivermectin in 100 mcg/kg single-dose, administered once a year, is the best candidate to replace DEC in mass treatments.
authors.affiliation: Institut territorial de recherches médicales Louis-Malardé, Papeete, Tahiti.
authors.forename: J
authors.initials: J
authors.lastname: Roux
authors.forename: P
authors.initials: P
authors.lastname: Perolat
authors.forename: J L
authors.initials: JL
authors.lastname: Cartel
authors.forename: J P
authors.initials: JP
authors.lastname: Boutin
authors.forename: Y
authors.initials: Y
authors.lastname: Sechan
authors.forename: M
authors.initials: M
authors.lastname: Larivière
authors.forename: M A
authors.initials: MA
authors.lastname: Aziz
mesh_terms: D000328:Adult; D000818:Animals; D002353:Carrier State / Q000188:drug therapy*; D004605:Elephantiasis, Filarial / Q000188:drug therapy*; D005368:Filariasis / Q000188:drug therapy*; D006801:Humans; D007559:Ivermectin / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D011114:Polynesia; D014957:Wuchereria
chemical_list: D007559:Ivermectin
vernacular_title: Etude de l'ivermectine pour le traitement de la filariose lymphatique due à Wuchereria bancrofti var. pacifica en Polynésie française.