title: Adenocarcinoma of the ethmoid sinuses. Results of a new protocol based on inductive chemotherapy combined with surgery. Four years experience.
abstract: New therapeutic modalities for Ethmoidal Adenocarcinomas are presented. Thirty three patients harbouring such a tumour have been treated during the last four years. Twenty three were included in the following protocol:--the first step consisted in inductive chemotherapy based on a four-day course of continuous cisplatine (CDDP) and 5-fluoro-uracyl (5-FU infusion)--the second step was the tumour removal, which was performed through a combined transfacial and subfrontal approach. A contralateral ethmoidectomy was always performed. The integrity of the sphenoidal sinus was systematically checked. The cranial base was reconstructed with madreporic coral grafts; then a large extra-dural pediculated galea flap was placed onto the anterior base to line the sub-frontal dura. The authors discuss the results of this series of rare tumours.
authors.affiliation: Department of Neurosurgery, C.H. Sainte-Anne, Paris, France.
authors.forename: F X
authors.initials: FX
authors.lastname: Roux
authors.forename: D
authors.initials: D
authors.lastname: Brasnu
authors.forename: M
authors.initials: M
authors.lastname: Menard
authors.forename: V
authors.initials: V
authors.lastname: Bassot
authors.forename: S
authors.initials: S
authors.lastname: Nguyen
authors.forename: S
authors.initials: S
authors.lastname: Donadieu
authors.forename: J L
authors.initials: JL
authors.lastname: Chodkiewicz
authors.forename: H
authors.initials: H
authors.lastname: Laccourreye
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005005:Ethmoid Sinus; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D012008:Recurrence
chemical_list: D002945:Cisplatin; D005472:Fluorouracil