title: Expression of a large family of POU-domain regulatory genes in mammalian brain development.
abstract: A novel region referred to as the POU-domain is present in two tissue-specific transcription factors, Pit-1 and Oct-2, that activate expression of genes specifying pituitary and lymphocyte phenotypes. We report the identification of multiple new members of a large family of POU-domain genes expressed in adult brain, and document that all the known mammalian POU-domain genes, including Pit-1 and Oct-2, are expressed widely in the developing nervous system.
authors.affiliation: Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093-0613.
authors.forename: X
authors.initials: X
authors.lastname: He
authors.forename: M N
authors.initials: MN
authors.lastname: Treacy
authors.forename: D M
authors.initials: DM
authors.lastname: Simmons
authors.forename: H A
authors.initials: HA
authors.lastname: Ingraham
authors.forename: L W
authors.initials: LW
authors.lastname: Swanson
authors.forename: M G
authors.initials: MG
authors.lastname: Rosenfeld
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000196:embryology*; D005786:Gene Expression Regulation; D005796:Genes; D005809:Genes, Regulator; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D013116:Spinal Cord / Q000196:embryology; D014157:Transcription Factors / Q000235:genetics
chemical_list: D014157:Transcription Factors