title: Availability of NSAIDH beta-cyclodextrin inclusion complexes.
abstract: The diffusion of a series of non steroidal antiinflammatory drugs through a silicone rubber membrane has been studied from suspensions both of the free and beta-cyclodextrin complexes forms at different pH values of the medium. Higher diffusion rates of the complexed forms as compared with the free ones and a rate-limiting effect of the apparent stability constant in the diffusion of the complexes were observed.
authors.forename: I
authors.initials: I
authors.lastname: Orienti
authors.forename: C
authors.initials: C
authors.lastname: Cavallari
authors.forename: V
authors.initials: V
authors.lastname: Zecchi
authors.forename: A
authors.initials: A
authors.lastname: Fini
mesh_terms: D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins; D047392:beta-Cyclodextrins
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003505:Cyclodextrins; D047392:beta-Cyclodextrins; C031215:betadex