title: Effect of neuraminidase on the adherence to salivary pellicle of Streptococcus sanguis and Streptococcus mitis.
abstract: Neuraminidase-sensitive adherence to experimental salivary pellicles was studied using eight strains of Streptococcus sanguis and five strains of Streptococcus mitis. Approximately 60% of the strains of each species showed significantly lower adherence to neuraminidase-treated versus untreated saliva-coated hydroxyapatite. In addition, the adherence of several of these streptococcal strains to saliva-coated hydroxyapatite and neuraminidase-treated saliva-coated hydroxyapatite was inhibited using galactose and N-acetyl-D-galactosamine. Results from these studies suggested that several salivary receptors mediate adherence of these species.
authors.affiliation: Microbiology Program, School of Dentistry, Minneapolis, Minn.
authors.forename: W F
authors.initials: WF
authors.lastname: Liljemark
authors.forename: C G
authors.initials: CG
authors.lastname: Bloomquist
authors.forename: L J
authors.initials: LJ
authors.lastname: Fenner
authors.forename: P J
authors.initials: PJ
authors.lastname: Antonelli
authors.forename: M C
authors.initials: MC
authors.lastname: Coulter
mesh_terms: D000116:Acetylgalactosamine / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects*; D003741:Dental Deposits / Q000503:physiopathology; D044622:Dental Pellicle; D005690:Galactose / Q000494:pharmacology; D006801:Humans; D006882:Hydroxyapatites; D009439:Neuraminidase / Q000494:pharmacology*; D012463:Saliva / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D012794:Sialic Acids / Q000493:pharmacokinetics; D013291:Streptococcus / Q000187:drug effects / Q000502:physiology*; D013298:Streptococcus sanguis / Q000187:drug effects / Q000502:physiology*
chemical_list: D006882:Hydroxyapatites; D012794:Sialic Acids; D009439:Neuraminidase; D000116:Acetylgalactosamine; D005690:Galactose