Comparison of the toxicity of two trichothecenes applied topically to brain and liver of rats.
T-2 toxin has been found previously to be markedly more toxic upon intracerebral than upon systemic administration. In order to study the generality of this difference, we have applied to brain and liver of albino rats two different types of trichothecenes: T-2 toxin as a representative of 'simple' and myrotoxin B as a representative of 'macrocyclic' members of this series. Myrotoxin B, when applied intracerebrally, was about 100 times more poisonous than T-2 toxin. In contrast, upon intrahepatic injection both compounds exhibited similar degrees of toxicity. The different behavior of the two trichothecenes in the organs tested may be due to local metabolic factors.
Bergmann
F
F
Department of Pharmacology, School of Pharmacy, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Yarom
R
R
Yagen
B
B
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D007267:Injections; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D012717:Sesquiterpenes / Q000633:toxicity*; D013605:T-2 Toxin / Q000008:administration & dosage / Q000633:toxicity*; D014255:Trichothecenes / Q000008:administration & dosage / Q000633:toxicity*
D012717:Sesquiterpenes; D014255:Trichothecenes; C060336:myrotoxin B; D013605:T-2 Toxin