Slow-reacting substance of anaphylaxis (SRS-A) activity in the synovial fluids of rabbits with antigen-induced arthritis.
Synovial fluids from rabbits with antigen-induced arthritis were investigated for the presence of slow-reacting substance of anaphylaxis (SRS-A) using biological assay in guinea-pig ileum. Inflamed joints from rabbits sacrificed within eight hours of the articular challenge disclosed SRS-A activity, indicating that peptidic leukotrienes may also be important in the physiopathology of acute articular inflammatory processes.
Brum-Fernandes
A J
AJ
1-Laboratory of Investigation in Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Brazil.
Cossermelli
W
W
Jancar
S
S
D000818:Animals; D001168:Arthritis / Q000378:metabolism*; D001169:Arthritis, Experimental / Q000378:metabolism*; D002417:Cattle; D011817:Rabbits; D013189:SRS-A / Q000378:metabolism*; D012710:Serum Albumin, Bovine; D013582:Synovial Fluid / Q000378:metabolism*; D013997:Time Factors
D013189:SRS-A; D012710:Serum Albumin, Bovine