Sublingual buprenorphine and pethidine for immediate postoperative pain relief in major gynecologic surgery: a comparative study.
The analgesic effect of sublingual buprenorphine 0.4 mg has been compared with pethidine 1 mg/kg given intramuscularly in 80 patients following major gynecologic operation. The results indicate a slower onset of action for sublingual buprenorphine in the first two hours (p less than 0.001), but it has a much longer duration and is more effective for pain relief (p less than 0.001) than pethidine. The main side-effects were nausea and vomiting which occurred after both treatments but with no significant difference.
Tungphaisal
S
S
Chandeying
V
V
Sutthijumroon
S
S
Aeuwpadung
S
S
D000286:Administration, Sublingual; D000328:Adult; D002047:Buprenorphine / Q000008:administration & dosage*; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D007273:Injections, Intramuscular; D008614:Meperidine / Q000008:administration & dosage*; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*
D002047:Buprenorphine; D008614:Meperidine