Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)-compl exe s, Part I: Synthesis.
The synthesis of the stereoisomeric 1,2-bis(3-hydroxyphenyl)ethylenediamines (1-4) from meso-1,2-bis(2-hydroxyphenyl)ethylenediamine and 3-methoxybenzaldehyde by a diaza-Cope-rearrangement and subsequent ether cleavage with BBr3 and their conversion into the [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)-complexes with K2PtCl4 (1-PtCl2 - 4-PtCl2) is described.
Jennerwein
M
M
Gust
R
R
Müller
R
R
Schönenberger
H
H
Engel
J
J
Berger
M R
MR
Schmähl
D
D
Seeber
S
S
Osieka
R
R
Atassi
G
G
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002942:Circular Dichroism; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C042922:dichloro(1,2-bis(4-hydroxyphenyl)ethylenediamine)platinum II