title: Giant cavernous hemangioma of the liver and multiple primary malignant tumors in a patient with suspected familial inhibition of natural killer cell activity--a case report.
abstract: A woman was operated on for a nonepithelial malignant tumor of the left leg and subsequently, for an epithelial carcinoma of the right breast and a borderline malignant tumor of the right ovary. She also developed a giant cavernous hemangioma that caused disseminated intravascular coagulation syndrome, which necessitated a left trisegmentectomy of the liver. Her family history suggested a hereditary predisposition to diverse malignant neoplasms, and also to giant cavernous hemangioma of the liver. Immunological evaluation disclosed selective inhibition of natural killer cell activity. Hormonal and hereditary factors are discussed in relation to the development of multiple primary tumors and giant cavernous hemangioma of the liver.
authors.affiliation: First Department of Surgery, Niigata University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tomiyama
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Muto
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Nemoto
authors.forename: Z
authors.initials: Z
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: H
authors.initials: H
authors.lastname: Miyakoshi
authors.forename: K
authors.initials: K
authors.lastname: Tamura
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology; D002277:Carcinoma / Q000235:genetics / Q000276:immunology / Q000473:pathology; D005260:Female; D006392:Hemangioma, Cavernous / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008113:Liver Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D010051:Ovarian Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology