Does cholecystokinin induce physiological satiety and sleep?
The effects of the intraperitoneal administration of two different anorexigenic doses (8 and 16 micrograms/kg) of cholecystokinin octapeptide (CCK-8) were studied on sleep parameters in the fasted rat. The results showed the following. With the high dose of CCK-8, there was a significant increase in slow wave sleep in the first 30 min of recording. There was no significant alteration of sleep parameters with the low dose of CCK-8. The two doses of CCK-8 induced spikes and unusual EEG slow waves. The EEG spectral analysis showed that CCK-8 slows the EEG waves frequency without modifying the total power energy in comparison with control wakefulness. The CCK faithfully replicates all the physiological effects of satiety, including normal sleep, is questionable.
de Saint Hilaire-Kafi
Z
Z
Neurobiologie des Régulations, Collège de France, Paris.
Depoortere
H
H
Nicolaïdis
S
S
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000187:drug effects* / Q000502:physiology; D012844:Sincalide / Q000494:pharmacology* / Q000502:physiology; D012890:Sleep / Q000187:drug effects* / Q000502:physiology
D012844:Sincalide