title: Budd Chiari syndrome, visceral arterial occlusions, recurrent fetal loss and the "lupus anticoagulant" in systemic lupus erythematosus.
abstract: A 30-year-old Chinese woman had been diagnosed as having systemic lupus erythematosus (SLE) at age 25 after 4 spontaneous abortions, all between 8 and 12 weeks of gestation. A year later she developed mild jaundice and at laparotomy, nodular enlargement of the right lobe of the liver and splenomegaly were seen. She was found to have a "lupus anticoagulant" and false positive test for syphilis (VDRL), but persistently negative antibodies to cardiolipin. Angiography demonstrated occlusion and stenoses of visceral abdominal arteries and hepatic venography also showed evidence of hepatic venous occlusions. She subsequently developed thyrotoxicosis which was treated with carbimazole, followed by radioactive iodine. The SLE and lupus anticoagulant were treated with systemic steroids (prednisolone) and anticoagulation (warfarin).
authors.affiliation: Lupus/Arthritis Research Unit, Rayne Institute, St. Thomas' Hospital, London, United Kingdom.
authors.forename: R A
authors.initials: RA
authors.lastname: Asherson
authors.forename: R P
authors.initials: RP
authors.lastname: Thompson
authors.forename: N
authors.initials: N
authors.lastname: MacLachlan
authors.forename: E
authors.initials: E
authors.lastname: Baguley
authors.forename: P
authors.initials: P
authors.lastname: Hicks
authors.forename: G R
authors.initials: GR
authors.lastname: Hughes
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology*; D000328:Adult; D001157:Arterial Occlusive Diseases / Q000209:etiology*; D001778:Blood Coagulation Disorders / Q000209:etiology*; D006502:Budd-Chiari Syndrome / Q000209:etiology*; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008638:Mesenteric Arteries; D011247:Pregnancy