Teratological evaluation of Juniperus sabina essential oil in mice.
Juniperus sabina essential oil was evaluated for its fetotoxic potential on mice. Pregnant dams were injected s.c. (15-45 or 135 mg essential oil/kg body weight) on days 6 to 15 of gestation. They were killed and the uterine contents were examined on day 19 of pregnancy. The fetuses were removed for examination. The dams of the two higher treated groups showed a significant weight loss as compared to controls. An hepatotoxicity was observed among females that resorbed their whole litter, thus indicating a greater susceptibility towards Juniperus sabina essential oil during pregnancy. The essential oil induced, in the three treated groups, an embryotoxicity as manifested by a statistically significant increase in the number of affected litters; but no fetotoxicity.
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Fournier
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Chamorro
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Salazar
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Paris
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Boudene
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D000818:Animals; D005260:Female; D051379:Mice; D009822:Oils, Volatile / Q000633:toxicity*; D010938:Plant Oils / Q000633:toxicity*; D013723:Teratogens; D014197:Trees / Q000032:analysis*
D009822:Oils, Volatile; D010938:Plant Oils; D013723:Teratogens