Castration increases striatal D-2 dopamine receptors in mid-life rats.
Effect of castration on [3H]-spiperone binding in the striatum of mid-life/mature rats was investigated. Four weeks after castration an increase in D-2 dopamine receptors was noted, and this was partially reduced by testosterone. These results suggest that testosterone may regulate striatal D-2 dopamine receptors in an age-dependent manner.
Watanabe
H
H
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Matsumoto
K
K
Imamura
L
L
Suzuki
Y
Y
D000375:Aging / Q000378:metabolism*; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D008297:Male; D009919:Orchiectomy; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology
D011954:Receptors, Dopamine; D013739:Testosterone