Reversibility of rat liver cirrhosis by medroxyprogesterone acetate.
The possible effects of a synthetic progesterone, medroxyprogesterone acetate (MPA), on carbon tetrachloride/phenobarbital (CCl4/PB)-induced rat liver injury were studied by morphological methods. CCl4/PB-treated rats showed extensive liver fibrosis consisting of procollagen type III aminoterminal propeptide-positive strands and fibres with concomitant extensive basement membrane deposits and fibronectin synthesis. MPA treatment after CCl4/PB-induced liver damage reduced alterations in cytoplasmic organelles, inflammation and hemorrhages and reversed the fibrosis, mostly around individual liver cells, possibly due to the normalization of cellular structure and function with a decrease in fibronectin deposits.
Stenbäck
F
F
Department of Pathology, University of Oulu, Finland.
Saarni
H U
HU
Rautio
A
A
Stengård
J
J
Sotaniemi
E A
EA
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy / Q000473:pathology; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008525:Medroxyprogesterone / Q000627:therapeutic use*; D008854:Microscopy, Electron; D009929:Organ Size / Q000187:drug effects; D010634:Phenobarbital / Q000506:poisoning; D051381:Rats; D011919:Rats, Inbred Strains
D008525:Medroxyprogesterone; D010634:Phenobarbital