The memory-enhancing effects of the piracetam-like nootropics are dependent on experimental parameters.
The effects of the nootropic agent piracetam and its congeners oxiracetam, pramiracetam and aniracetam on the retention performance of mice in a passive-avoidance situation are dependent on the intensity of the foot-shock applied. This phenomenon is observed upon both pre-trial and post-trial drug administration.
Mondadori
C
C
Pharmaceutical Research Department, CIBA-GEIGY Limited, Basle, Switzerland.
Ducret
T
T
Borkowski
J
J
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D010889:Piracetam / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology; D011760:Pyrrolidinones / Q000494:pharmacology*
D011759:Pyrrolidines; D011760:Pyrrolidinones; C038438:pramiracetam; C036466:aniracetam; C040619:oxiracetam; D010889:Piracetam