The effects of repeated parenteral administration of chelating agents on the distribution and excretion of uranium.
The effects of repeated ip administration of gallic acid, 4,5-dihydroxy-1,3-benzenedisulfonic acid (Tiron), diethylenetriaminepentaacetic acid (DTPA), and 5-aminosalicylic acid (5-AS) on the distribution and excretion of uranium were assessed in male Swiss mice. Only Tiron significantly increased the amount of uranium excreted into urine and feces. A significant decrease in the concentration of uranium in liver, spleen and bone was observed after administration of Tiron, whereas injection of gallic acid or DTPA resulted in a significant decrease in the concentration of the metal in the liver. The results show that Tiron was consistently the most effective chelator of those tested in the treatment of uranium poisoning after repeated daily administration of the metal.
Domingo
J L
JL
Laboratory of Toxicology and Biochemistry, School of Medicine, University of Barcelona, Reus, Spain.
Ortega
A
A
Llobet
J M
JM
Paternain
J L
JL
Corbella
J
J
D000818:Animals; D002614:Chelating Agents / Q000008:administration & dosage / Q000494:pharmacology*; D005243:Feces / Q000032:analysis; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000378:metabolism; D004369:Pentetic Acid / Q000494:pharmacology; D014501:Uranium / Q000378:metabolism* / Q000652:urine
D002614:Chelating Agents; D009942:Organometallic Compounds; C005460:uranyl acetate; D014501:Uranium; D004369:Pentetic Acid