title: Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor.
abstract: The sequence of 5,037 amino acids composing the ryanodine receptor from rabbit skeletal muscle sarcoplasmic reticulum has been deduced by cloning and sequencing the complementary DNA. The predicted structure suggests that the calcium release channel activity resides in the C-terminal region of the receptor molecule, whereas the remaining portion constitutes the 'foot' structure spanning the junctional gap between the sarcoplasmic reticulum and the transverse tubule.
authors.affiliation: Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takeshima
authors.forename: S
authors.initials: S
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Ishida
authors.forename: K
authors.initials: K
authors.lastname: Kangawa
authors.forename: N
authors.initials: N
authors.lastname: Minamino
authors.forename: H
authors.initials: H
authors.lastname: Matsuo
authors.forename: M
authors.initials: M
authors.lastname: Ueda
authors.forename: M
authors.initials: M
authors.lastname: Hanaoka
authors.forename: T
authors.initials: T
authors.lastname: Hirose
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002121:Calcium Channel Blockers / Q000378:metabolism; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics*; D008969:Molecular Sequence Data; D009132:Muscles / Q000378:metabolism*; D011487:Protein Conformation; D012333:RNA, Messenger / Q000235:genetics; D011817:Rabbits; D011950:Receptors, Cholinergic / Q000235:genetics* / Q000302:isolation & purification; D015183:Restriction Mapping; D019837:Ryanodine Receptor Calcium Release Channel; D012519:Sarcoplasmic Reticulum / Q000502:physiology / Q000648:ultrastructure; D014158:Transcription, Genetic
chemical_list: D002121:Calcium Channel Blockers; D012333:RNA, Messenger; D011950:Receptors, Cholinergic; D019837:Ryanodine Receptor Calcium Release Channel; D004247:DNA