Relationship of lung geometry to the development of pleural abnormalities in insulation workers exposed to asbestos.
The relationship of respiratory airway and airspace geometry to radiographic evidence of pleural abnormality consistent with asbestos exposure was studied in 178 construction insulators. Lung geometry was assessed from tracings of radiographic shadows, and the measures taken were tracheal length and diameter, subcarinal angle, right and left lung lengths, and upper, middle, and lower lung widths. Important modifying variables--age, height, weight, exposure estimates, and smoking history--were included in a logistic regression model to test the significance of the lung geometry measurements as predictors of the presence or absence of pleural abnormality. No such relationships were found. Neither were there any differences in prevalence or severity of pleural disease between the right and left sides which might have been found if airway geometry were a significant determinant of asbestos pleural disease. These results do not support the hypothesis that lung geometry is a host risk factor for the development of asbestos-related pleural disease.
Delfino
R
R
Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada.
Ernst
P
P
Bourbeau
J
J
D000328:Adult; D000367:Age Factors; D001195:Asbestosis / Q000503:physiopathology*; D006801:Humans; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology; D008875:Middle Aged; D010994:Pleura / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012307:Risk Factors