Inhibitory effects of gossypol analogs on human sperm motility.
Aqueous-soluble gossypol Schiff's bases, SP562: bis-8,8'-[(N-(2-(dimethylamino)ethyl]-iminomethylene]- [1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2- binaphthalene dihydrochloride; SP563: bis-8,8'-[(N-(2-(diethylamino)ethyl]-iminomethylene]-1,1',6,6',7,7 '- hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'-binaphthalene++ + dihydrochloride; and SP564: bis-8,8'-[(N-(2-(diethylamino)propyl]-iminomethylene]- 1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'- binaphthalene dihydrochloride, were investigated for their effects on human sperm motility. SP564, which has the longest alkyl substituent of the Schiff's base, appeared to exert the greatest inhibitory effects on human sperm motility. These inhibitory effects were even greater than those caused by (+/-)gossypol acetic acid at the same concentration.
Tanphaichitr
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Department of Obstetrics and Gynecology, Loeb Institute for Medical Research, Ottawa Civic Hospital, University of Ottawa, Ontario, Canada.
Agulnick
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Hill
J A
JA
D004305:Dose-Response Relationship, Drug; D006072:Gossypol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D013075:Sperm Capacitation; D013081:Sperm Motility / Q000187:drug effects*; D013329:Structure-Activity Relationship
D006072:Gossypol