title: Plasma dilution during transdermal clonidine antihypertensive monotherapy.
abstract: In eight hypertensive patients treated with transdermal clonidine for one year, there was plasma dilution, as shown by a reduction in serum sodium, hemoglobin, and serum protein levels. Free water clearance did not change significantly. Plasma dilution was likely sustained by increased water intake due to "dry mouth", as frequently seen with central acting drugs such as clonidine.
authors.affiliation: Royal C. Johnson VA Medical Center, Sioux Falls, South Dakota.
authors.forename: E T
authors.initials: ET
authors.lastname: Zawada
authors.forename: R A
authors.initials: RA
authors.lastname: Jensen
authors.forename: L
authors.initials: L
authors.lastname: Williams
authors.forename: D W
authors.initials: DW
authors.lastname: Zeigler
authors.forename: M L
authors.initials: ML
authors.lastname: Kauker
mesh_terms: D000279:Administration, Cutaneous; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001798:Blood Proteins / Q000032:analysis; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D010953:Plasma Volume; D012964:Sodium / Q000097:blood
chemical_list: D000959:Antihypertensive Agents; D001798:Blood Proteins; D006454:Hemoglobins; D012964:Sodium; D003000:Clonidine