title: [Evaluation of hepatic function by hepatobiliary scintigraphy using factor analysis].
abstract: Factor analysis of hepatobiliary scintigraphy using 99mTc-N-pyridoxyl-5-methyltryptophan (99mTc-PMT) was performed, and functional factor of liver parenchyma (FA-hepatogram) was obtained. Two parameters (peak time, T 1/2) were calculated from this hepatogram. A good correlation was obtained between these parameters and ICG-R15; furthermore, these parameters were prolonged in patients with normal volunteers, chronic hepatitis, compensated and decompensated liver cirrhosis in this order. Conventional hepatogram by ROI method (ROI-hepatogram) was not suitable for the evaluation of global liver function in condition such as a large intrahepatic mass, intrahepatic gall bladder, dilatation of biliary tree, and severe liver cirrhosis. But, even in such cases, FA-hepatogram was useful for the evaluation of global liver function.
authors.forename: O
authors.initials: O
authors.lastname: Shimomura
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: A
authors.initials: A
authors.lastname: Tsuji
authors.forename: Y
authors.initials: Y
authors.lastname: Takagi
authors.forename: S
authors.initials: S
authors.lastname: Tomiguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Koga
authors.forename: A
authors.initials: A
authors.lastname: Kojima
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: Y
authors.initials: Y
authors.lastname: Hirota
mesh_terms: D001659:Biliary Tract / Q000000981:diagnostic imaging*; D005163:Factor Analysis, Statistical; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging*; D008107:Liver Diseases / Q000503:physiopathology; D008111:Liver Function Tests / Q000379:methods*; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D011730:Pyridoxal / Q000031:analogs & derivatives; D011877:Radionuclide Imaging; D014364:Tryptophan / Q000031:analogs & derivatives
chemical_list: D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; C038081:technetium Tc 99m pyridoxyl-5-methyltryptophan; D011730:Pyridoxal; D014364:Tryptophan