[Value of determining dexamethasone in the rapid adrenal suppression test].
During the dexamethasone suppression test (DST), we evaluated the relationship between the 8 a.m. dexamethasone (DXM) level and the pharmacokinetics of this corticoid after the oral administration of a single dose at midnight of DXM (1 mg) in 7 healthy subjects. The half-life time of the terminal phase for DXM was 283 min +/- 132 min (mean +/- s.d.). The 8 a.m. DXM level, which is positively correlated with the DXM half-life time, is useful for the interpretation of the DST. On the other hand, no correlation was observed between the 8 a.m. plasma cortisol and DXM levels in 21 healthy subjects. However, the negative correlation between the dose of DXM/kg and post-DXM cortisol level suggests the possibility of adjusting the dose of DXM in obese patients.
Lamiable
D
D
Laboratoire de Pharmacologie et Chimie des Explorations Fonctionnelles, Centre Hospitalier Régional, Reims.
Sulmont
V
V
Millart
H
H
Delemer
B
B
Caron
J
J
Choisy
H
H
D000284:Administration, Oral; D000304:Adrenal Cortex Function Tests; D000328:Adult; D003907:Dexamethasone / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D010912:Pituitary-Adrenal Function Tests
D003907:Dexamethasone; D006854:Hydrocortisone
Intérêt du dosage de la dexaméthasone dans le test de freination rapide surrénalienne.