Association of trisomy 8 and squamous differentiation in an endometrial adenocarcinoma.
Cytogenetic analysis was performed on a case of endometrial adenocarcinoma in which 10% to 15% of the tumor showed squamous differentiation. Of 26 cells examined, all had trisomy 1q and monosomy 16; four cells (15%) also showed trisomy 8. Trisomy 8 is an unusual finding in endometrial carcinoma, having been reported in only one other case, which was an adenosquamous carcinoma. Our findings suggest that trisomy 8 may be a marker of squamous differentiation in endometrial carcinoma.
Fletcher
J A
JA
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.
Aster
J C
JC
Morton
C C
CC
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D014314:Trisomy; D014594:Uterine Neoplasms / Q000235:genetics* / Q000473:pathology