Biochemical studies on phthalic esters V. Comparative studies on in vitro hydrolysis of di-n-butyl phthalate isomers in rats.
In connection with testicular effects in rats of dibutyl phthalate (DBP) and monobutyl phthalate (MBP), the in vitro hydrolysis of dibutyl esters of phthalate isomers such as isophthalic and terephthalic acids was compared using preparations from rat liver, kidney, pancreas, small intestine, and blood. The results suggest considerable substrate specificity and the participation of different enzymes for hydrolysis of these esters.
Takahashi
T
T
Division of Medical Chemistry, National Institute of Hygienic Sciences, Tokyo, Japan.
Tanaka
A
A
D000818:Animals; D003993:Dibutyl Phthalate / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D066298:In Vitro Techniques; D007536:Isomerism; D008297:Male; D008670:Metals / Q000494:pharmacology; D008862:Microsomes, Liver / Q000378:metabolism; D010795:Phthalic Acids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D008670:Metals; D010795:Phthalic Acids; D003993:Dibutyl Phthalate