title: Fatal neonatal cardiomyopathy associated with cataract and mitochondrial myopathy.
abstract: Three patients suffering from the neonatal form of a syndrome characterized by congenital cataract, hypertrophic cardiomyopathy, and mitochondrial myopathy are described. The patients died at 7, 10 and 18 days, respectively from cardiorespiratory failure. Mitochondrial abnormalities were observed in the heart and skeletal muscle. Despite the presence of a severe lactic acidaemia pointing to a disturbed pyruvate oxidation rate in vivo, a normal pyruvate oxidation rate was demonstrated in skeletal muscle homogenates. The activities of several enzymes of the mitochondrial respiratory chain appeared to be normal, indicating an intact respiratory chain. A myoglobinopenia could be excluded. The activities of some mitochondrial enzymes and the concentration of myoglobin increase with age.
authors.affiliation: Institute of Paediatrics, University of Nijmegen, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Smeitink
authors.forename: R C
authors.initials: RC
authors.lastname: Sengers
authors.forename: J M
authors.initials: JM
authors.lastname: Trijbels
authors.forename: W
authors.initials: W
authors.lastname: Ruitenbeek
authors.forename: O
authors.initials: O
authors.lastname: Daniëls
authors.forename: A M
authors.initials: AM
authors.lastname: Stadhouders
authors.forename: M J
authors.initials: MJ
authors.lastname: Kock-Jansen
mesh_terms: D001344:Autopsy; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000473:pathology; D002386:Cataract / Q000150:complications / Q000151:congenital*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008929:Mitochondria, Heart / Q000473:pathology; D008931:Mitochondria, Muscle / Q000473:pathology