Transferable 5-nitroimidazole resistance in the Bacteroides fragilis group.
We report the characterization of a strain of Bacteroides vulgatus, BV17, that exhibits a moderate resistance to 5-nitroimidazoles and carries plasmids of 4.5, 5, 7.7, and 56 kb. A genetic determinant involved in this resistance is carried by the 7.7 +/- 0.2-kb plasmid (pIP417). This plasmid can be introduced and replicated in a sensitive strain of B. fragilis 638R by transformation or by conjugation. In the latter case, the transfer may involve mobilization by the 56-kb conjugative plasmid (pIP418) regularly found in transconjugants but not in transformants.
Breuil
J
J
Laboratoire de Microbiologie, Centre Hospitalier, Villeneuve Saint Georges, France.
Dublanchet
A
A
Truffaut
N
N
Sebald
M
M
D001439:Bacteroides / Q000235:genetics*; D001441:Bacteroides fragilis / Q000187:drug effects / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D004352:Drug Resistance, Microbial / Q000235:genetics; D009593:Nitroimidazoles / Q000494:pharmacology*; D011815:R Factors
D004269:DNA, Bacterial; D009593:Nitroimidazoles; C052587:4-nitroimidazole