[Sensitivity of the retrograde uptake of H3-serotonin to imipramine and trazodone in patients with endogenous depression treated with antidepressive drugs].
The potency of imipramine (IMI) and trazodone (TRA) to inhibit (3H)-serotonin intake in unipolar and bipolar endogenous depressed patients (women aged 17 to 57 years) was evaluated before and during the antidepressant treatment. The potency of IMI was lower and that of TRA higher in patients as compared to controls. The both drugs' potencies became normal in patients treated with antidepressants. The significant decrease of imipramine binding sites density (Bmax) was evident after the treatment as against the normal levels. Significant correlation was observed between a severity of the patient's state evaluated using Hamiltone depression rating scale and the TRA potency but not IMI potency or Bmax. The data suggest different mechanisms regulating the serotonin uptake sensitivity to IMI and TRA. These are apparently involved in the pathogenesis of endogenous depression.
Katasonov
A B
AB
Beliaev
B S
BS
Zlobina
G P
GP
Faktor
M I
MI
Brusov
O S
OS
D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D003470:Culture Media; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007099:Imipramine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008875:Middle Aged; D012701:Serotonin / Q000097:blood*; D012702:Serotonin Antagonists; D014196:Trazodone / Q000494:pharmacology*; D014316:Tritium
D000928:Antidepressive Agents; D003470:Culture Media; D012702:Serotonin Antagonists; D014316:Tritium; D012701:Serotonin; D007099:Imipramine; D014196:Trazodone
Chuvstvetel'nost' obratnogo zakhvata 3H-serotonina k imipraminu i trazodonu u bol'nykh endogennymi depressiiami pri lechenii antidepressantami.