[A study of ivermectin in the treatment of lymphatic filariasis due to Wuchereria bancrofti var. pacifica in French Polynesia].
Forty carriers of 20 or more W. bancrofti var. pacifica per ml were blind administered ivermectin at 50, 100, 150 or 200 mcg/kg doses. The rate of successful treatment was 100% with the 4 dosages. The percentage cure rate and the decrease percentage in the microfilarial count were significantly higher in persons treated with 100, 150 and 200 mcg/kg than in persons treated with 50 mcg/kg. Frequency and intensity of side-reactions were similar to those observed during treatment with DEC; they were more frequent and severe in persons with greatest microfilaremia but did not depend on the dosage. Ivermectin in 100 mcg/kg single-dose, administered once a year, is the best candidate to replace DEC in mass treatments.
Roux
J
J
Institut territorial de recherches médicales Louis-Malardé, Papeete, Tahiti.
Perolat
P
P
Cartel
J L
JL
Boutin
J P
JP
Sechan
Y
Y
Larivière
M
M
Aziz
M A
MA
D000328:Adult; D000818:Animals; D002353:Carrier State / Q000188:drug therapy*; D004605:Elephantiasis, Filarial / Q000188:drug therapy*; D005368:Filariasis / Q000188:drug therapy*; D006801:Humans; D007559:Ivermectin / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D011114:Polynesia; D014957:Wuchereria
D007559:Ivermectin
Etude de l'ivermectine pour le traitement de la filariose lymphatique due à Wuchereria bancrofti var. pacifica en Polynésie française.