title: Rat blood and brain amino acid pattern in short term experimental diabetes.
abstract: Some serum and brain amino acid variations occurring in animals with short term streptozotocin-diabetes (24 h) are studied in this work. Diabetic animals showed an increase in serum of the three branched-chain amino acids as well as an increase in free tryptophan, besides a decrease in total serum tryptophan and in the tryptophan/competitor amino acids ratio. In brain, the three branched-chain amino acids increased, but there were no variation in whole brain tryptophan. Nevertheless, by studying levels of tryptophan in different brain regions, an increase in medulla-pons was recorded. This circumstance could be explained by the increase in free serum tryptophan levels, in agreement with several authors who assign this reason for brain tryptophan.
authors.affiliation: Departamento de Fisiología, Facultad de Biología, Santiago de Compostela, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Atienza
authors.forename: M
authors.initials: M
authors.lastname: Aldegunde
authors.forename: J A
authors.initials: JA
authors.lastname: Veira
authors.forename: A
authors.initials: A
authors.lastname: Lorenzo
authors.forename: R
authors.initials: R
authors.lastname: Conejero
mesh_terms: D000596:Amino Acids / Q000032:analysis* / Q000097:blood; D000818:Animals; D001923:Brain Chemistry; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014364:Tryptophan / Q000032:analysis* / Q000097:blood
chemical_list: D000596:Amino Acids; D014364:Tryptophan