Effect of a steroidal (prednisolone) and nonsteroidal (indomethacin) antiinflammatory agent on ovulation and follicular accumulation of prostaglandin F2 alpha in sheep.
The antiinflammatory steroid, prednisolone, was administered to sheep during the preovulatory period. The drug did not produce a blockade of follicular rupture. However, prednisolone negated a rise in production of prostaglandin (PG) F2 alpha characteristic of preovulatory follicles. Indomethacin, a nonsteroidal antiinflammatory agent, was 100% effective in preventing ovulation. Levels of PGF2 alpha within follicular tissue were very low following treatment with indomethacin. These findings indicate that ovulation can occur in the absence of a preovulatory elevation in follicular accumulation of PGF2 alpha. Potency of antiinflammatory drugs as inhibitors of ovulation appears to hinge upon their ability to cause a marked suppression in follicular synthesis of prostaglandins.
Murdoch
W J
WJ
Department of Animal Science, University of Wyoming, Laramie 82071.
D000818:Animals; D015237:Dinoprost / Q000378:metabolism*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D006080:Ovarian Follicle / Q000187:drug effects / Q000378:metabolism*; D010060:Ovulation / Q000187:drug effects*; D011239:Prednisolone / Q000494:pharmacology*; D012756:Sheep; D013997:Time Factors
D011239:Prednisolone; D015237:Dinoprost; D007213:Indomethacin