Inheritance pattern of platelet membrane fluidity in Alzheimer disease.
The fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene in labeled platelet membranes, an index of membrane fluidity, is a stable, familial trait that is associated with a clinically distinct subtype of Alzheimer disease. Complex segregation analysis of this continuous variable was performed on 95 members of 14 pedigrees identified through probands who had autopsy-confirmed or clinically diagnosed Alzheimer disease. The results suggest that platelet membrane fluidity is controlled by a single genetic locus, PMF, with two alleles that have additive effects. The PMF locus appears to explain approximately 80% of the total variation in platelet membrane fluidity within the families of patients with Alzheimer disease.
Chakravarti
A
A
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA.
Slaugenhaupt
S A
SA
Zubenko
G S
GS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000097:blood / Q000235:genetics*; D001791:Blood Platelet Disorders / Q000235:genetics*; D005260:Female; D005454:Fluorescence Polarization; D006801:Humans; D008297:Male; D008560:Membrane Fluidity; D008875:Middle Aged; D008957:Models, Genetic; D011336:Probability