title: Effects of chronic developmental lead exposure on monkey neuroanatomy: visual system.
abstract: The effects of lead on specific areas of the visual system were examined in two groups of monkeys (Macaca fascicularis). The first group (N = 3) received 2000 micrograms Pb/kg/day from infancy onward, while the second group (N = 4) received 25 micrograms Pb/kg/day from birth onward. Monkeys were killed at approximately 6 years of age. Areas of the visual system, including optic nerve, lateral geniculate nucleus, and primary area V1 and one visual projection area V2, were examined by a combination of light and electron microscopy and Golgi impregnation. No effect of lead on optic nerve was identified, nor were there consistent differences in the lateral geniculate nucleus. Within areas V1 and V2, the neuronal volume density was significantly reduced in the high dose compared to the low dose group. Moreover, analysis of the dendritic arborization by Golgi analysis revealed a relative decrease in the number of arborizations among pyramidal neurons in both areas V1 and V2. These data suggest that lead exposure beginning during the early postnatal period may result in changes in cytoarchitecture in visual areas V1 and V2.
authors.affiliation: Toxicology Research Division, Health and Welfare Canada, Ottawa.
authors.forename: K R
authors.initials: KR
authors.lastname: Reuhl
authors.forename: D C
authors.initials: DC
authors.lastname: Rice
authors.forename: S G
authors.initials: SG
authors.lastname: Gilbert
authors.forename: J
authors.initials: J
authors.lastname: Mallett
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005829:Geniculate Bodies / Q000187:drug effects* / Q000473:pathology; D007854:Lead / Q000633:toxicity*; D008252:Macaca fascicularis; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects; D009900:Optic Nerve / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D014793:Visual Cortex / Q000187:drug effects* / Q000473:pathology
chemical_list: D007854:Lead