title: [Direct screening for producers of antibiotics among the Micromonospora].
abstract: A test system was developed for screening organisms producing antibiotics of definite chemical groups or mechanisms of action. The system includes efficient selection of cultures belonging to a definite microbiological taxon (genus Micromonospora), investigation of their biological and taxonomic features, the use of specific selective media with high concentrations of definite antibiotics for isolating antibiotic-producing cultures from natural substrates, the use of specific methods for antibiotic chemical isolation at the initial stages of the screening and chromatographic study of the screened compounds. The system provided efficient screening of valuable antibiotics in a short period.
authors.forename: M V
authors.initials: MV
authors.lastname: Bibikova
authors.forename: L P
authors.initials: LP
authors.lastname: Ivanitskaia
authors.forename: E M
authors.initials: EM
authors.lastname: Singan
authors.forename: S N
authors.initials: SN
authors.lastname: Vostrov
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D003470:Culture Media; D004345:Drug Industry / Q000379:methods*; D008847:Micromonospora / Q000254:growth & development / Q000378:metabolism*; D013678:Technology, Pharmaceutical; D014586:USSR
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003470:Culture Media
vernacular_title: Napravlennyĭ poisk produtsentov antibiotikov sredi mikromonospor.