Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease.
Monoamine oxidase A and B (MAO A and B) are the central enzymes that catalyze oxidative deamination of biogenic amines throughout the body. The regional locations of genes encoding MAO A and B on the X chromosome were determined by using full-length cDNA clones for human MAO A and B, respectively. Using somatic cell hybrids, in situ hybridization, and field-inversion gel electrophoresis as well as deletion mapping in a patient with Norrie disease, we concluded that these two genes are close to each other and to the DXS7 locus (Xp 11.3).
Lan
N C
NC
Division of Biological Sciences, School of Pharmacy, University of Southern California, Los Angeles 90033.
Heinzmann
C
C
Gal
A
A
Klisak
I
I
Orth
U
U
Lai
E
E
Grimsby
J
J
Sparkes
R S
RS
Mohandas
T
T
Shih
J C
JC
D000818:Animals; D001766:Blindness / Q000201:enzymology / Q000235:genetics*; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000235:genetics*; D015183:Restriction Mapping; D012160:Retina / Q000002:abnormalities*; D014960:X Chromosome
D004247:DNA; D008995:Monoamine Oxidase