Nanometre-level analysis demonstrates that lipid flow does not drive membrane glycoprotein movements.
Nanometre-level analyses of the movements of membrane glycoproteins tagged with gold particles demonstrate that diffusing particles are not under the influence of a lipid flow, although a subset of particles which appear attached to the cytoskeleton are moving rearward.
Sheetz
M P
MP
Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110.
Turney
S
S
Qian
H
H
Elson
E L
EL
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D001692:Biological Transport; D003208:Concanavalin A; D015638:Cytochalasin D; D003572:Cytochalasins / Q000494:pharmacology; D003599:Cytoskeleton / Q000187:drug effects; D004058:Diffusion; D006046:Gold; D008264:Macrophages / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000032:analysis / Q000378:metabolism*; D008563:Membrane Lipids / Q000502:physiology*; D051379:Mice; D008832:Microchemistry; D008954:Models, Biological; D015739:Nocodazole
D001562:Benzimidazoles; D003572:Cytochalasins; D008562:Membrane Glycoproteins; D008563:Membrane Lipids; D003208:Concanavalin A; D015638:Cytochalasin D; D006046:Gold; D015739:Nocodazole