title: The origin of the low-frequency microphonic in the first cochlear turn of guinea-pig.
abstract: Low-frequency microphonic potentials (100 Hz to 2000 Hz) have been measured in the first turn of the guinea pig cochlea before and after a variety of manipulations of the cochlea. These included ablation of the apical turns, iontophoresis of streptomycin, dc current injection into the first turn, acoustic trauma and two-tone interference with pure tones. These manipulations indicate that the low-frequency microphonic measured in the first turn and at the round window is generated predominantly by the hair cells of this region. It is a convenient and relatively uncomplicated indicator of the integrity of the mechano-electrical transduction process of these cells.
authors.affiliation: Department of Physiology, University of Western Australia, Nedlands.
authors.forename: R B
authors.initials: RB
authors.lastname: Patuzzi
authors.forename: G K
authors.initials: GK
authors.lastname: Yates
authors.forename: B M
authors.initials: BM
authors.lastname: Johnstone
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001305:Auditory Fatigue / Q000502:physiology; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology*; D003051:Cochlea / Q000502:physiology*; D003055:Cochlear Microphonic Potentials; D004558:Electric Stimulation; D005072:Evoked Potentials, Auditory; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000502:physiology* / Q000601:surgery; D012405:Round Window, Ear / Q000187:drug effects / Q000502:physiology*; D013307:Streptomycin / Q000494:pharmacology; D000159:Vestibulocochlear Nerve / Q000502:physiology*
chemical_list: D013307:Streptomycin