Chromosomal rearrangement on chromosome 11q14-q21 in T cell acute lymphoblastic leukemia.
Deletion and translocation involving the bands 11q14 and 11q21 have been detected in five patients with T cell acute lymphoblastic leukemia (ALL). The breakpoint on chromosome 11 was on the same band as that previously described in some acute nonlymphocytic leukemias: monocytic or myelomocytic. The existence of a new nonrandom rearrangement involving bands 11q14-q21 is postulated in ALL. An unusual rearrangement on 11q13 in a patient with T cell ALL is also reported.
Berger
R
R
Unité INSERM U. 301, CNRS, Hopital Saint Louis, Paris.
Le Coniat
M
M
Derré
J
J
Vecchione
D
D
Chen
S J
SJ
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic