[The effect of chronic aluminum loading on lysosomal enzymes in serum and organ homogenates. Methodologic aspects].
The influence of aluminium administration both on the lysosomes and on the activity of DNA-dependent enzymes in rats with intact kidney function or following partial nephrectomy was investigated. The elevation in free N-acetyl-beta-D-glucosaminidase in connection with a decrease of latent beta-NAG-level in liver, spleen and kidneys may be supposed a dose dependent aluminium damage of the lysosomes. Moreover, the decrease of free and total beta-glucuronidase in the liver and spleen could be caused by a selective inhibition of synthesis of this enzyme.
Laske
V
V
Klinik für Innere Medizin, Friedrich-Schiller-Universität, Jena.
Stein
G
G
Müller
A
A
Bräunlich
H
H
Fleck
C
C
Linss
W
W
D000117:Acetylglucosamine / Q000378:metabolism / Q000652:urine; D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004798:Enzymes / Q000097:blood / Q000378:metabolism*; D005260:Female; D005966:Glucuronidase / Q000378:metabolism / Q000652:urine; D008099:Liver / Q000201:enzymology / Q000648:ultrastructure; D008247:Lysosomes / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004798:Enzymes; D003404:Creatinine; D000535:Aluminum; D005966:Glucuronidase; D000117:Acetylglucosamine
Einfluss einer chronischen Aluminiumbeladung auf lysosomale Enzyme im Serum und in Organhomogenaten. Methodische Aspekte.