Lethal cardiac toxicity after cisplatin and 5-fluorouracil chemotherapy. Report of a case with necropsy study.
This article presents a patient affected with epidermoid carcinoma of the soft palate who developed a dilated myocardiopathy with aortic embolism and fatal left cardiac failure after treatment with cisplatin (100 mg/m2, day 1) and 5-fluorouracil (1 g/m2/day i.v. days 2-6). The postmortem necropsy study showed diffuse interstitial edema and intracytoplasmic vacuolization of myocytes, without inflammatory changes. These findings were interpreted as acute toxic myocardiopathy, probably due to 5-fluorouracil treatment. Although the patient also received cisplatin, metoclopramide, allopurinol, thiethylperazine, and amitriptyline, before the onset of clinical symptoms, these drugs were not considered to play an important role in the production of this cardiopathy because of the dosage, necropsy findings, and lack of previous report.
Martin
M
M
Servicio de Oncología Médica, Hospital Universitario San Carlos, Madrid, Spain.
Diaz-Rubio
E
E
Furió
V
V
Blázquez
J
J
Almenarez
J
J
Fariña
J
J
D001018:Aortic Diseases / Q000139:chemically induced*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced*; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D004617:Embolism / Q000139:chemically induced*; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010157:Palatal Neoplasms / Q000188:drug therapy; D010160:Palate, Soft
D002945:Cisplatin; D005472:Fluorouracil