[Clinico-experimental substantiation of the use of carnitine and cobalamin in the treatment of anorexia nervosa].
The effects of carnitine and cobamamide were studied at the unspecific stage of anorexia nervosa treatment. Carnitine and cobamamide accelerated the amelioration of the patients' somatic state (body weight gain, gastrointestinal functions normalization). Experimental psychological technique of involved deciphering discovered that latent fatigue disappeared and mental performance sharply increased under carnitine and cobamamide treatment. Experimental model of anorexia nervosa was used for electron microscopy and morphometry of neocortical tissue structure after starvation period and in feeding rehabilitation with carnitine and cobamamide. These drugs were shown to promote cerebral mass growth, increase in neocortical layers thickness, pyramidal neurons volume, that led to full restoration of normal structure of neocortex. The data provide a basis suitable to recommend carnitineand cobamamide to treat patients with relevant anorexia.
Korkina
M B
MB
Korchak
G M
GM
Medvedev
D I
DI
D000818:Animals; D000856:Anorexia Nervosa / Q000188:drug therapy* / Q000473:pathology; D001835:Body Weight / Q000187:drug effects*; D002331:Carnitine / Q000008:administration & dosage*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000648:ultrastructure; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D051379:Mice; D008808:Mice, Inbred CBA; D008854:Microscopy, Electron; D009929:Organ Size / Q000187:drug effects; D014805:Vitamin B 12 / Q000008:administration & dosage*
D014805:Vitamin B 12; D002331:Carnitine
Kliniko-éksperimental'noe obosnovanie primeneniia karnitina i kobalamina dlia lecheniia nervnoĭ anoreksii.