Efficacy of rimantadine hydrochloride in the treatment of influenza infection of mice.
Rimantadine HCl was assessed for its effect on influenza A virus titer in lungs of infected BALB/c mice. Rimantadine administered orally via drinking water, with and without an intraperitoneal prophylactic loading dose, was compared to intraperitoneal administration. Mice were infected with a non-lethal dose of influenza A/Port Chalmers/H3N2 virus and the pulmonary virus titers were determined at intervals over a 21 day period. Prophylactic treatment with rimantadine followed by oral administration resulted in up to a 4 log10 reduction in pulmonary virus titer. The oral doses given to the mice were comparable on a mg/kg/day basis to those recommended for treatment of human infections. Reductions in pulmonary virus titers also occurred after intraperitoneal rimantadine treatment which included a prophylactic dose, but the reductions in pulmonary virus titers were less striking and not consistent over the course of infection. There were no significant reductions in pulmonary virus titers by either route if treatment was started 8 h after exposure to virus.
Herrmann
J E
JE
Division of Infectious Diseases, University of Massachusetts Medical School, Worcester 01655.
Bruns
M
M
West
K
K
Ennis
F A
FA
D000218:Adamantane / Q000031:analogs & derivatives*; D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D009980:Influenza A virus / Q000187:drug effects / Q000302:isolation & purification; D007274:Injections, Intraperitoneal; D008168:Lung / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D012299:Rimantadine / Q000008:administration & dosage / Q000627:therapeutic use*
D012299:Rimantadine; D000218:Adamantane