title: One- and two-dimensional echocardiography in bodybuilders using anabolic steroids.
abstract: The object of this study was to investigate the possible concentric increase in the left ventricular (LV) wall thickness by intensive strength training and to differentiate between the specific effect of the strength training itself and the influence of anabolic drugs. In this study 21 top-level bodybuilders [users of anabolic steroids (A): n = 14; non-users (N): n = 7] underwent one-dimensional and two-dimensional echocardiography as well as a cycle ergometer test. In both groups blood pressure at rest and during ergometric exercise was within the normal range. In spite of the same amount of time being spent on training, A showed significantly better power results than N. Total heart volume (A = 11.3 +/- 0.9 ml.kg-1; N = 11.9 +/- 0.9 ml.kg-1) and LV muscle mass were almost identical in A and N and correlated significantly with body weight and lean body mass respectively. The body dimension-related diastolic LV diameter was significantly lower in A (0.567 +/- 0.062 mm.kg-1) than in N (0.639 +/- 0.040 mm.kg-1). An increase in the LV posterior wall (p less than 0.01) and septum thickness (ns) resulted in increased LV wall thickness:diameter (p less than 0.01) and LV muscle mass:volume (p less than 0.05) ratios in A (0.458 +/- 0.590; 1.38 +/- 0.25 g.ml-1) in comparison to N (0.356 +/- 0.077; 1.16 +/- 0.17 g.ml-1). The septal:posterior wall thickness ratio was similar for both groups.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Sports and Performance Medicine, University of the Saarland, Saarbrücken, Federal Republic of Germany.
authors.forename: A
authors.initials: A
authors.lastname: Urhausen
authors.forename: R
authors.initials: R
authors.lastname: Hölpes
authors.forename: W
authors.initials: W
authors.lastname: Kindermann
mesh_terms: D000328:Adult; D045930:Anabolic Agents / Q000494:pharmacology*; D004452:Echocardiography; D005080:Exercise Test; D006352:Heart Ventricles / Q000033:anatomy & histology / Q000187:drug effects; D006801:Humans; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D005082:Physical Exertion; D010809:Physical Fitness; D013177:Sports; D016276:Ventricular Function; D014891:Weight Lifting
chemical_list: D045930:Anabolic Agents