Flow cytometric analysis DNA content in esophageal carcinoma. Correlation with histologic and clinical features.
Cell nuclear DNA content was determined by flow cytometric analysis in 36 patients with esophageal carcinoma. Aneuploid DNA content was observed in 25 cases (69.4%). The relationships among DNA content, histopathologic features, and clinical characteristics were investigated. The patients with aneuploid DNA content had a high frequency of local lymph node metastasis, invasion to surrounding tissues, poor histologic differentiation, and advanced tumor stages as compared with those patients with diploid DNA content. In contrast to this, there was no correlation in patients' sex, age, and the sites of the disease.
Yu
J M
JM
Radiobiological Department, Shandong Tumor Institute, China.
Yang
L H
LH
Guo-Qian
Chen
Y T
YT
Li
X
X
Zhong
W X
WX
Chen
J C
JC
Tian
G D
GD
D000328:Adult; D000368:Aged; D000782:Aneuploidy; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000556:secondary; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness
D004273:DNA, Neoplasm