title: Evaluation of the developmental toxicity of succinate tartrates in rats.
abstract: The potential for succinate tartrates (ST) to induce developmental toxicity in Sprague-Dawley CD rats has been evaluated. ST dose levels of 250, 500 and 1000 mg/kg body weight/day were administered in the drinking-water on days 6-15 of gestation. Control animals received distilled water. Caesarean sections were performed on gestation day 20 and the foetuses were removed for teratological evaluation. No significant maternal or developmental toxicity was observed at any dose level. Based on these observations, the no-observed-effect level for ST developmental toxicity is greater than or equal to 1 g/kg/day, which was the highest dose tested.
authors.affiliation: Procter and Gamble Company, Ivorydale Technical Center, Cincinnati, OH.
authors.forename: D W
authors.initials: DW
authors.lastname: Petersen
authors.forename: G P
authors.initials: GP
authors.lastname: Daston
authors.forename: J L
authors.initials: JL
authors.lastname: Schardein
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002614:Chelating Agents; D004326:Drinking; D004435:Eating; D005260:Female; D005865:Gestational Age; D008297:Male; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013223:Statistics as Topic; D013386:Succinates / Q000633:toxicity*
chemical_list: D002614:Chelating Agents; D013386:Succinates; C060064:2-(1,2-dicarboxyethoxy)-3-hydroxybutanedioic acid; C060065:2,3-bis(1,2-dicarboxyethoxy)butanedioic acid