[Structural analysis of carbohydrate chains of normal and myeloma immunoglobulins G using HPLC].
A comparative analysis of carbohydrate chains from human normal IgG and myeloma IgG (subclass 4) was carried out using HPLC. It is shown that both IgGs contain the same carbohydrate chains (biantennary and bisected) but the relative amount of bisected and incomplete chains (with fewer terminal galactose residues) is higher in myeloma IgG4. Two earlier unknown minor oligosaccharides were isolated from normal IgG and structurally studied by means of the partial hydrolysis and the Smith degradation.
Arbatskiĭ
N P
NP
Martynova
M D
MD
Aleshkin
V A
VA
Derevitskaia
V A
VA
D002241:Carbohydrates / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D009194:Myeloma Proteins / Q000032:analysis*; D009844:Oligosaccharides / Q000032:analysis
D002241:Carbohydrates; D007074:Immunoglobulin G; D009194:Myeloma Proteins; D009844:Oligosaccharides
Strukturnyĭ analiz uglevodnykh tsepeĭ normal'nogo i mielomnogo immunoglobulinov G s pomoshch'iu VEZhKh.