title: [Preoperative endocavitary curietherapy of stage Ib-IIa-IIb cervical carcinoma. Personal observations].
abstract: From 1980 through 1984, 41 patients with squamous cell cervix carcinoma and 1 with adenosquamous carcinoma were treated with preoperative irradiation. Clinical stages were Ib in 6 patients, IIa in 24, and IIb in 12. At surgery, lymph node metastases were found in 5 cases, and residual tumors in 8. The latter risk patients were given further external radiotherapy after surgery. Overall three-year survival rates for FIGO stage Ib was 100%; 91.6% for stage IIa, and 83% for stage IIb (minimum follow-up: 3 years). Two patients died from locoregional recurrence of the disease 12-24 months after the treatment, and 2 from distant metastases; 5 patients have showed signs of local improvement. Our results seem to point to pelvic lymph node involvement as the major prognostic factor: in fact, 40% only of the patients with involved lymph nodes is alive. Actuarial survival rates show 90.4% of patients to be alive at 5 years. Tolerance to the combined use radiotherapy and surgery was fair: no severe side-effects were observed. Even though our results are encouraging, a randomized study is still recommended to verify the actual value of this treatment versus combined surgery and radiotherapy or radiotherapy alone.
authors.affiliation: Divisione di Radioterapia, Ospedale San Giovanni Vecchio, Torino.
authors.forename: A M
authors.initials: AM
authors.lastname: Gabriele
authors.forename: A
authors.initials: A
authors.lastname: Boidi Trotti
authors.forename: F
authors.initials: F
authors.lastname: Fracchia
authors.forename: C
authors.initials: C
authors.lastname: Rosmino
authors.forename: P
authors.initials: P
authors.lastname: Rovea
authors.forename: A
authors.initials: A
authors.lastname: Tardy
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D011300:Preoperative Care; D011879:Radiotherapy Dosage; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*
vernacular_title: Curieterapia endocavitaria pre-operatoria nel carcinoma della cervice uterina agli stadi Ib-IIa-IIb. Osservazioni personali.