title: [Changes in catecholamines of the striatum during 5% oxygen administration and the alleviating effects of flunarizine in rats].
abstract: Five percent oxygen was administered to rats under controlled respiration. The concentrations of catecholamines and their metabolites (dopamine, HVA, DOPAC, norepinephrine) were measured during 5% oxygen administration and subsequent recovery period. Flunarizine, a calcium channel blocker, was administered and its effects on catecholamine fluctuations were studied. Results were as follows. Dopamine increased with 5% oxygen administration. DOPAC and norepinephrine decreased and no changes were seen in HVA. After 20 min of hypoxia, catecholamine contents returned to the control levels in another 2 hours of air breathing. When flunarizine was administered in advance, changes in catecholamine content appeared to be lower during 5% oxygen administration and subsequent recovery period.
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Masuda
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Miyazaki
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D005444:Flunarizine / Q000627:therapeutic use*; D000860:Hypoxia / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002395:Catecholamines; D005444:Flunarizine