Endometrial stromal sarcoma of low-grade malignancy. Immunohistochemical and three-dimensional reconstruction study with special emphasis on the inadequate terminology of endolymphatic stromal myosis.
We report two cases of endometrial stromal sarcoma of low-grade malignancy (so-called endolymphatic stromal myosis) with special emphasis on the histogenesis and mode of invasion. The microscopic and immunohistochemical features of the tumor cells resembled those of endometrial stromal cells. A three-dimensional reconstruction study of the tumor disclosed that it grew by forming a horn- or crown-like structure between and along the vessels. The tumor then protruded into the vascular lumina with a covering of endothelial cells. Immunohistochemical study showed that the vascular system was not lymphatic but venous. We therefore think that "endolymphatic stromal myosis" is a misnomer.
Suzuki
M
M
Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.
Aizawa
S
S
Ushigome
S
S
D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012509:Sarcoma / Q000473:pathology*; D009626:Terminology as Topic; D014594:Uterine Neoplasms / Q000473:pathology*