title: Hypothyroidism may account for reduced prolactin secretion in lactating rats bearing paraventricular area lesions.
abstract: Lesions in the paraventricular area (PVA) of lactating rats have been found to inhibit PRL release. We have examined whether this reduced PRL release is due to hypothyroidism resulting from destruction of the PVA. Rats were made hypothyroid by thyroidectomy on day 15 of pregnancy or by methimazole treatment from the day of parturition. Electrolytic lesions were placed bilaterally in the PVA on day 15 of pregnancy. The following variables were studied: weight gain of the pups, nursing behavior, thyroid status, and release of PRL. The treatments did not affect the time the mothers spent with the pups but reduced the daily weight gain of the pups. Rats with PVA lesions had reduced PRL and TSH levels during lactation compared with controls. Suckling-induced PRL release after 6 h of separation of mothers and pups was less in PVA-lesioned rats than in controls, but T4-treatment did overcome this blunted response in rats with lesions. Levels of T3 and T4 in PVA-lesioned rats were lower than those in controls. In rats made hypothyroid by thyroidectomy or treatment with methimazole, PRL levels were lower and TSH levels higher than those in euthyroid mothers on days 8, 15, and 22 of lactation. Suckling after 6 h of separation of pups and mothers raised PRL levels both in control and methimazole-treated rats, but in the latter animals the response was blunted. It is suggested that the reduced PRL release in lactating rats with PVA lesions could be due to hypothyroidism resulting from these lesions.
authors.affiliation: Department of Endocrinology Growth and Reproduction, Erasmus University, Medical School, Rotterdam, The Neterlands.
authors.forename: W J
authors.initials: WJ
authors.lastname: de Greef
authors.forename: J M
authors.initials: JM
authors.lastname: Rondeel
authors.forename: P D
authors.initials: PD
authors.lastname: van der Vaart
authors.forename: P
authors.initials: P
authors.lastname: van der Schoot
authors.forename: S W
authors.initials: SW
authors.lastname: Lamberts
authors.forename: T J
authors.initials: TJ
authors.lastname: Visser
mesh_terms: D000818:Animals; D005260:Female; D007037:Hypothyroidism / Q000150:complications / Q000378:metabolism*; D007774:Lactation / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D008098:Litter Size / Q000187:drug effects; D008713:Methimazole / Q000494:pharmacology; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D013972:Thyrotropin / Q000378:metabolism; D013974:Thyroxine / Q000378:metabolism / Q000494:pharmacology; D014284:Triiodothyronine / Q000378:metabolism
chemical_list: D014284:Triiodothyronine; D008713:Methimazole; D011388:Prolactin; D013972:Thyrotropin; D013974:Thyroxine