[Pharmacokinetics of antipyrine in viral and alcoholic lesions of the liver].
Parameters of antipyrine pharmacokinetics have been studied in 82 patients with viral, alcoholic and combined liver affections and in 19 healthy subjects. All the patients exhibited changes showing a reduction of liver function responsible for drug metabolism. Disturbances of antipyrine pharmacokinetics were more pronounced in acute alcohol-aggravated hepatitis B than in hepatitis B without alcoholic aggravation.
Tsyrkunov
V M
VM
Bushma
M I
MI
Garelik
P V
PV
Novitskiĭ
G K
GK
Zavodnik
L B
LB
D000328:Adult; D000983:Antipyrine / Q000493:pharmacokinetics*; D001711:Biotransformation; D006509:Hepatitis B / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008108:Liver Diseases, Alcoholic / Q000378:metabolism*; D008111:Liver Function Tests
D000983:Antipyrine
Farmakokinetika antipirina pri virusnom i alkogol'nom porazhenii pecheni.