title: The late occurrence of urinary tract damage in patients successfully treated by radiotherapy for cervical carcinoma.
abstract: Urinary tract complications apparently resulting from radiation therapy for carcinoma of the cervix can occur as long as 30 years after cessation of such treatment. Patients generally present with urinary incontinence and often are treated by standard operative methods that usually are unsuccessful. Incontinence is related to bladder fibrosis, urethral nonfunction and vesicovaginal fistuLa formation, and may be accompanied by bilateral ureteral obstruction. Of 11 patients with late complications of radiotherapy 4 had upper tract deterioration, 4 had vesicovaginal fistulas, 5 had an incompetent urethra aNd 9 had a fibrotic, noncompliant areflexive bladder. Treatment was aimed at providing adequate low pressure storage capacity and consisted of augmentation cystoplasty in 5 patients, repair of the fistula in 4 and correction of urethral dysfunction in 5. Women who complain of incontinence and/or irritable bladder symptoms with a history of radiotherapy for cervical carcinoma should be evaluated for fistuLa formation, urethral incompetence, and detrusor areflexia and fibrosis before treatment is done.
authors.affiliation: Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor.
authors.forename: J
authors.initials: J
authors.lastname: Zoubek
authors.forename: E J
authors.initials: EJ
authors.lastname: McGuire
authors.forename: F
authors.initials: F
authors.lastname: Noll
authors.forename: J O
authors.initials: JO
authors.lastname: DeLancey
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects*; D013997:Time Factors; D001743:Urinary Bladder / Q000528:radiation effects; D001745:Urinary Bladder Diseases / Q000209:etiology*; D014549:Urinary Incontinence / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*; D014718:Vesico-Ureteral Reflux / Q000209:etiology*; D014719:Vesicovaginal Fistula / Q000209:etiology*