[Lipid peroxidation in aged patients. Influence of an antioxidant combination (vitamin C-vitamin E-rutin)].
Lipoperoxidation has an important role in the normal processes of the cell-life. The induction is produced by oxygen-derived free radicals which attack the membrane phospholipids. Such an attack is modulated by an enzymatic protection system (superoxide dismutase, catalase, glutathione peroxidase, glutathione transferase) and by a non-enzymatic one (vitamin C, vitamin E...). In various pathologic conditions, a dispoise takes place between radical attack and antiradical protection. The place taken by lipoperoxidation in the ageing process seems to be fundamental. We report here the results of a study carried out in aged and sick patients who were given an antioxidant medicamentous combination made from Vitamin C, Vitamin E and Rutin. Our results evidence that such a synergistic combination does modify both enzymatic protection system and lipoperoxidation, this latter showing a decrease under treatment.
Courtière
A
A
Cotte
J M
JM
Pignol
F
F
Jadot
G
G
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D012431:Rutin / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*
D004338:Drug Combinations; D014810:Vitamin E; D012431:Rutin; D001205:Ascorbic Acid
Etude de la lipidoperoxydation chez le malade âgé. Influence d'une association antioxydante (vitamine C - vitamine E - rutine).