Acute cardiovascular response to monoamine oxidase inhibitors: a prospective assessment.
Despite the widespread use of monoamine oxidase inhibitors (MAOIs) and the well-known adverse event of hypertensive crisis, few studies have addressed the acute cardiovascular response to an MAOI dose. We prospectively measured pulse and blood pressure changes just before and at 1, 2, 3, and 4 hours after MAOI administration in 18 patients. Significant but asymptomatic increases from baseline in mean systolic and diastolic blood pressure occurred within 2 hours after MAOI administration, with return to near baseline by 4 hours. The mechanism of this reaction is unknown.
Keck
P E
PE
Epidemiology Laboratory, McLean Hospital, Belmont, Massachusetts 02178.
Vuckovic
A
A
Pope
H G
HG
Nierenberg
A A
AA
Gribble
G W
GW
White
K
K
D000379:Agoraphobia / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects*; D002032:Bulimia / Q000188:drug therapy; D003866:Depressive Disorder / Q000188:drug therapy; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy*; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D010200:Panic / Q000187:drug effects; D010293:Pargyline / Q000009:adverse effects; D010624:Phenelzine / Q000009:adverse effects; D011446:Prospective Studies; D011674:Pulse / Q000187:drug effects*; D014191:Tranylcypromine / Q000009:adverse effects
D008996:Monoamine Oxidase Inhibitors; D014191:Tranylcypromine; D010293:Pargyline; D010624:Phenelzine