Wegener's granulomatosis: treatment failure on conventional therapy.
We report a patient with Wegener's granulomatosis who was initially stabilized, but later relapsed with multiorgan involvement while taking high oral doses of cyclophosphamide (3.7 mg/kg body weight/day) and prednisolone. Remission was achieved with a combined therapy consisting of intermittent intravenous boluses of cyclophosphamide, oral prednisolone, plasmapheresis and oral trimethoprim-sulfamethoxazole. Discussion includes evaluation of the relative beneficial effect of the four treatment constituents.
Locht
H
H
Department of Medicine, University Hospital, Linköping, Sweden.
Lindström
F D
FD
D000328:Adult; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000628:therapy*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010956:Plasmapheresis; D011239:Prednisolone / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use
D003520:Cyclophosphamide; D011239:Prednisolone; D014295:Trimethoprim; D013420:Sulfamethoxazole