[The modifying influence of adenosylcobalamin on the transplacental carcinogenic effect of N-nitroso-N-ethylurea in organ cultures of the kidneys of DBA/2 mice].
Transplacental effect of cobalamin coenzyme, adenosylcobalamin (Adocbl), on the carcinogenic action of N-nitroso-N-ethylurea (ENU) was studied in culture of the mouse embryonic kidney tissue by histoautoradiography. Coenzyme methylmalonyl-CoA-mutase, Adocbl, injected into DBA/2 mice in the prenatal period did not stimulate the proliferative activity of epithelial cells of the embryonic kidney. The treatment with Adocbl did not intensify hyperplastic changes common for the early stages of carcinogenesis. The frequency of hyperplastic changes mainly of focal proliferation in kidney explants with the combined administration was considerably lower than with the isolated action of the carcinogen and amounted to 8.7% and 21.5%, respectively (P less than 0.001).
Golenko
O D
OD
Ryzhova
N I
NI
Miasishcheva
N V
NV
D000818:Animals; D001345:Autoradiography; D003038:Cobamides / Q000494:pharmacology*; D004347:Drug Interactions; D004622:Embryo, Mammalian; D005038:Ethylnitrosourea / Q000633:toxicity*; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced / Q000473:pathology; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D051379:Mice; D008811:Mice, Inbred DBA; D009336:Necrosis; D009924:Organ Culture Techniques; D010920:Placenta / Q000187:drug effects*; D011247:Pregnancy
D003038:Cobamides; C000913:cobamamide; D005038:Ethylnitrosourea
Modifitsiruiushchee vliianie adenozilkobalamina na transplatsentarnyĭ kantserogennyĭ éffekt N-nitrozo-N-étilmocheviny v organnykh kul'turakh pochek mysheĭ linii DBA/2.