Sclerosing orbital pseudotumor: a unique clinicopathologic entity.
A case of orbital pseudotumor is presented that histologically showed dense fibrosis invading bone and adjacent sinuses, and failed to respond to either steroids or radiation therapy. "Orbital pseudotumor" remains a sobriquet for a variety of clinical and histopathologic entities including a monomorphous lymphocytic benign or malignant neoplasm; a polymorphous reactive inflammatory lesion; and a densely fibrosing sclerotic variant that appears to behave more aggressively, often locally invades adjacent structures, and may be related to a multifocal fibrosclerosis that also includes retroperitoneal fibrosis, Riedel's sclerosing thyroiditis, mediastinal fibrosis, and sclerosing cholangitis. This "sclerosing orbital pseudotumor" is felt to represent a unique clinicopathologic entity, and an approach to its treatment is described.
Weissler
M C
MC
Division of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill.
Miller
E
E
Fortune
M A
MA
D000328:Adult; D001706:Biopsy; D003131:Combined Modality Therapy; D005355:Fibrosis; D006801:Humans; D008297:Male; D009915:Orbit / Q000473:pathology*; D009916:Orbital Diseases / Q000473:pathology* / Q000628:therapy; D010256:Paranasal Sinuses / Q000473:pathology; D012598:Sclerosis; D009626:Terminology as Topic