Relationship of milk intake and vitamin K supplementation to vitamin K status in newborns.
Vitamin K status was evaluated by measuring blood acarboxyprothrombin (PIVKA-II) levels on the fifth day of life. The incidence of PIVKA-II-positive infants was higher in breast-fed babies than in those given supplementary (mixed) feeding. The median of total amount of milk intake during the first 3 days was significantly lower in PIVKA-II-positive infants than in PIVKA-II-negative infants among infants given both types of feedings. In addition, there was a significant negative correlation between a positive PIVKA-II proportion and the amount of milk intake in the breast-fed babies. The minimum dose of vitamin K2 necessary to prevent a positive PIVKA-II reading was 15 micrograms among babies with a normal absorption potential.
Motohara
K
K
Department of Internal Medicine, Kamiamakusa General Hospital, Kumamoto, Japan.
Matsukane
I
I
Endo
F
F
Kiyota
Y
Y
Matsuda
I
I
D000818:Animals; D015415:Biomarkers; D001942:Breast Feeding; D004305:Dose-Response Relationship, Drug; D005527:Food, Fortified; D006801:Humans; D007225:Infant Food; D007231:Infant, Newborn; D008892:Milk; D011498:Protein Precursors; D011516:Prothrombin / Q000031:analogs & derivatives / Q000097:blood; D014812:Vitamin K / Q000008:administration & dosage* / Q000097:blood*; D014813:Vitamin K Deficiency / Q000097:blood / Q000517:prevention & control
D015415:Biomarkers; D011498:Protein Precursors; D014812:Vitamin K; C008208:acarboxyprothrombin; D011516:Prothrombin