[Observation on immunogenic effect of intradermal inoculation of small dose of hepatitis B vaccine].
The immunogenic effect of intradermal inoculation of small dose of HB vaccine was evaluated in 120 seronegative villagers (men: 55, women: 65) whose ages were from 3 to 70. These participants were randomly divided into subcutaneous group (I) and intradermal group (II). The results showed that the anti-HBs seroconversion rates and P/N ratios of those who showed the seroconversion for group I, II were 98.4%, 98.3% and 88.0, 89.4, respectively after the third injection. There was no significant difference between the groups in the seroconversion rates and their P/N ratios (P greater than 0.05). It is concluded that in these two groups small doses of HB vaccine have stimulated high immune responses. Intradermal small dose regimen is safe, more economic and will make the HB vaccine available to more people.
Liu
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D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006801:Humans; D007271:Injections, Intradermal; D008297:Male; D008875:Middle Aged; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage
D014761:Viral Hepatitis Vaccines