Anti-inflammatory activity of Echinops echinatus.
Anti-inflammatory studies were conducted on an ethanol extract of Echinops echinatus whole plant. The extract effectively inhibited the acute inflammation induced in rats by carrageenan, formaldehyde and adjuvant and the chronic arthritis induced by formaldehyde and adjuvant. The extract was more effective parenterally than orally. The toxicity studies showed reasonable safety warranting further studies.
Singh
B
B
Department of Pharmacology, Banaras Hindu University, Varanasi, India.
Gambhir
S S
SS
Pandey
V B
VB
Joshi
V K
VK
D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents; D001169:Arthritis, Experimental / Q000188:drug therapy; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D005557:Formaldehyde; D007194:India; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010653:Phenylbutazone / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D005557:Formaldehyde; D002351:Carrageenan; D010653:Phenylbutazone