title: Bioactivity of some chemotherapeutic agents in selected polyethylene glycol ointment bases.
abstract: Six different chemotherapeutic agents were individually incorporated in each of fourteen selected polyethylene glycol ointment bases, and their bioactivities were assessed using different diffusion techniques. The prepared medicated ointments were evaluated for drug release using the standard microbiological agar cup diffusion, the long period method and the short period method, as well as dialysis through artificial kidney membrane. On the basis of consistency, stability and diffusion results, formulation 11 was the most suitable base for ampicillin, formulation 14 for oxytetracycline HCl, formulation 10 and 9 for neomycin sulphate, and preparation 10 for chloramphenicol. On the basis of the results of drug release, it was evident that formulation 3 was the best for ampicillin and chloramphenicol, formulation 2 for erythromycin, formulation 4 for neomycin sulphate, formulation 12 for sulphadimidine, and formulation 14 for oxytetracycline HCl.
authors.forename: A
authors.initials: A
authors.lastname: Farouk
authors.forename: S
authors.initials: S
authors.lastname: Béla
authors.forename: R
authors.initials: R
authors.lastname: Géza
authors.forename: S
authors.initials: S
authors.lastname: Mohamed
authors.forename: I
authors.initials: I
authors.lastname: Abdei Hadi
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis*; D004058:Diffusion; D009824:Ointments; D011092:Polyethylene Glycols
chemical_list: D000900:Anti-Bacterial Agents; D009824:Ointments; D011092:Polyethylene Glycols