[The 3-phase reaction of cells of an MDCK culture to long-term exposure to antiviral chemical preparations].
A study was made of the effect of antiviral drugs remantadine and deitephorine on dynamics in the changes in structure-function parameters, mitotic activity, protein and nucleic acid synthesis in the Madin-Darby canine kidney cell culture. The application of methodical complex and regression analysis methods, the approximation of experimental data with analytical functions showed general regularity in the monolayer cell population response to the effect of drugs. In the response of cell populations three phases are distinguished: the first phase--transient inhibition; the second phase--relative compensation; the third phase--pathological cell destructive process.
Votiakov
V I
VI
Erokhina
I R
IR
Amvros'eva
T V
TV
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002478:Cells, Cultured; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D046911:Macromolecular Substances; D008938:Mitosis / Q000187:drug effects; D009930:Organic Chemicals; D012044:Regression Analysis; D012299:Rimantadine / Q000494:pharmacology; D013997:Time Factors
D000998:Antiviral Agents; D046911:Macromolecular Substances; D009930:Organic Chemicals; D012299:Rimantadine; C060204:deitiforin
Trekhfaznaia reaktsiia kletok kul'tury MDCK na dlitel'noe vozdeĭstvie protivovirusnykh khimiopreparatov.