[Effect of fepromaron on the enzyme activity of the liver monooxygenase system].
The effect of an anticoagulant with the indirect action phepromaron on some parameters of the liver monooxygenase system (the activity of N-demethylase of amidopyrine, p-hydroxylase of aniline, levels of cytochromes P-450 and b5) was studied on rats receiving adequate nutrition. In the first hours of the investigation (at 3, 12, 24 hours) the intragastric administration of phepromaron in a dose of 10 mg/kg produced a decrease of p-hydroxylase activity, the levels of cytochrome P-450 and b5. At 72 hours the indices of the monooxygenase system significantly increased. Administration of phepromaron to animals receiving zyxorin (in a dose of 60 mg/kg per day for 3 days) failed to change the inducing effect of the drug on the activity of the liver monooxygenase system enzymes in all periods of the investigation.
Imambaev
S E
SE
Amirov
B B
BB
D015110:4-Hydroxycoumarins / Q000494:pharmacology*; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001559:Benzhydryl Compounds / Q000494:pharmacology; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010105:Oxygenases / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D015110:4-Hydroxycoumarins; D000925:Anticoagulants; D001559:Benzhydryl Compounds; C004791:phepromaron; D010105:Oxygenases; C016914:flumecinol
Vliianie fepromarona na aktivnost' fermentov monooksigenaznoĭ sistemy pecheni.