[Microbiological and pharmacokinetic studies on flomoxef in ophthalmologic field].
Microbiological and pharmacokinetic studies were carried out on flomoxef (FMOX, 6315-S), a new oxacephem parenteral antibiotic, in the ophthalmologic field. The results obtained are summarized as follows. FMOX has a broad antimicrobial activity spectrum against Gram-positive and Gram-negative bacteria. The MIC distribution against Staphylococcus aureus isolated from clinical cases was less than or equal to 0.20 - greater than or equal to 100 micrograms/ml with the peak value of 0.39 micrograms/ml. Concentrations of FMOX in aqueous humor and ocular tissues were determined after intravenous injection of 50 mg/kg to rabbits. FMOX showed a peak level of 2.2 micrograms/ml in the aqueous humor at 1/2 hour after administration with the ratio to serum level of 3.4%. Levels of FMOX in external and internal ocular tissues were 12.7 - 76.5 micrograms/g, less than 0.8 - 34.4 micrograms/g (ml) at 1/2 hour after administration, respectively. From these results, we concluded that FMOX may be expected to be a useful and valuable agent against infections in the ophthalmologic field.
Ooishi
M
M
Department of Ophthalmology, School of Medicine, Niigata University.
Sakaue
F
F
Oomomo
A
A
Tazawa
H
H
D000818:Animals; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000382:microbiology; D002511:Cephalosporins / Q000493:pharmacokinetics* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005123:Eye / Q000378:metabolism*; D005128:Eye Diseases / Q000382:microbiology; D006801:Humans; D011817:Rabbits
D002511:Cephalosporins; C045693:flomoxef