Regional differences in the distribution of norepinephrine and epinephrine in human cerebral cortex: a neurochemical study using HPLC and electrochemical detection.
We performed neurochemical quantitation of the catecholamines dopamine (DA), norepinephrine (NE) and epinephrine (E) and their major metabolites 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) in 22 cortical regions of 6 postmortem human brains. Statistical analysis indicated a clear regional difference for NE and E while DA and all the metabolites under study are homogeneously distributed over the cortex. These consistent regional differences suggest the possible role of NE and E as neurotransmitters or neuromodulators in human cerebral cortex.
Herregodts
P
P
Department of Neurology, Vrije Universiteit Brussel, Belgium.
Michotte
Y
Y
Ebinger
G
G
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000368:Aged; D002540:Cerebral Cortex / Q000032:analysis* / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000032:analysis* / Q000502:physiology; D004563:Electrochemistry; D004837:Epinephrine / Q000032:analysis* / Q000502:physiology; D006719:Homovanillic Acid / Q000032:analysis; D006801:Humans; D008734:Methoxyhydroxyphenylglycol / Q000032:analysis; D008875:Middle Aged; D009638:Norepinephrine / Q000032:analysis* / Q000502:physiology
D015102:3,4-Dihydroxyphenylacetic Acid; D008734:Methoxyhydroxyphenylglycol; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid; D004837:Epinephrine