title: Effects of therapeutic coronary reperfusion on aspartate aminotransferase isoenzymes in sera of patients with acute myocardial infarction.
abstract: We examined the kinetics of the catalytic activities of aspartate aminotransferase (AST, EC 2.6.1.1) isoenzymes in serum of 28 patients with myocardial infarction who were to receive either intracoronary urokinase--reperfusion angiographically proved--or conventional therapy (control group). Cytosolic (soluble) AST (s-AST) activity in serum increased rapidly immediately after recanalization, reaching a maximum 12 h after the onset of infarction. In the control group, this peak was reached 28 h after the onset (P less than 0.001). Peak s-AST activity was similar in the two groups. Peak activity and peak time for mitochondrial AST (m-AST) were the same for the two groups of patients; intervention that affects myocardial perfusion caused only a slight additional increase in m-AST activity in the early post-infarct period. There may be advantages to measuring m-AST, which is briefly influenced by reperfusion, instead of the usual cytosolic enzymes for assessment of myocardial damage in patients with myocardial infarction treated with thrombolytic therapy.
authors.affiliation: 1. Laboratorio Analisi Chimico-Cliniche, Brescia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Panteghini
authors.forename: F
authors.initials: F
authors.lastname: Pagani
authors.forename: C
authors.initials: C
authors.lastname: Cuccia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001219:Aspartate Aminotransferases / Q000097:blood*; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D008929:Mitochondria, Heart / Q000201:enzymology; D009203:Myocardial Infarction / Q000201:enzymology* / Q000628:therapy; D015425:Myocardial Reperfusion; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
chemical_list: D007527:Isoenzymes; D001219:Aspartate Aminotransferases; D014568:Urokinase-Type Plasminogen Activator