Effect of pindolol versus atenolol on lipid profile in hypertensive patients.
The effect of pindolol (a beta-blocker with intrinsic sympathomimetic activity, ISA) on fasting plasma lipid profile in 30 hypertensive patients was compared with atenolol (without ISA) in a crossover single blind study. Both drugs lowered blood pressure. HDL-cholesterol increased significantly with pindolol (from 1.15 +/- 0.05 to 1.34 +/- 0.05 mmol/l at 12 weeks, P less than 0.001), but not with atenolol. VLDL-cholesterol increased with atenolol (from 0.57 +/- 0.09 to 0.86 +/- 0.14 mmol/l at 12 weeks, P less than 0.002), while there was no change with pindolol. These changes in lipoprotein profile suggest a more favourable effect of pindolol than of atenolol on lipid profile.
Notghi
A
A
Department of Medicine, Western General Hospital, Edinburgh, U.K.
Riemersma
R A
RA
Anderton
J L
JL
Oliver
M F
MF
D000328:Adult; D001262:Atenolol / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010869:Pindolol / Q000494:pharmacology / Q000627:therapeutic use*
D008074:Lipoproteins; D001262:Atenolol; D010869:Pindolol