title: Urinary metabolites of 14C-labelled FCE 22101 in animals.
abstract: The metabolism of 14C-FCE 22101 has been studied by radio-HPLC in the urine of various animal species. Five main chromatographic peaks were detected and named, in order of decreasing polarity, P, P1, X, UD (unchanged drug) and LP. P1 is the open beta-lactam ring metabolite obtained by the action of dehydropeptidase. The stability of FCE 22101 and P1 is pH-dependent, and differences between species in urinary metabolic patterns might therefore be partially explained by different urinary pH values.
authors.affiliation: Farmitalia Carlo Erba, Research and Development, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Strolin Benedetti
authors.forename: R
authors.initials: R
authors.lastname: Battaglia
authors.forename: G
authors.initials: G
authors.lastname: Vicario
authors.forename: R
authors.initials: R
authors.lastname: Roncucci
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000652:urine*; D001711:Biotransformation; D015780:Carbapenems; D004285:Dogs; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D007769:Lactams; D008252:Macaca fascicularis; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D007769:Lactams; C040033:ritipenem