Neurotensin-induced polydipsia: a structure-activity study.
Neurotensin (NT) and equimolar concentrations of NT fragments were microinjected into the lateral cerebral ventricle of water-deprived rats. NT (10 micrograms) increased water intake 146% in the first 15 min following injection. While NT1-11 and NT10-13 had no effect on water intake, NT8-13 increased water intake 101%. The polydipsia produced by NT8-13 was statistically equivalent to that produced by NT. The results are discussed in relation to a proposed model of the NT receptor.
Hawkins
M F
MF
Department of Psychology, Louisiana State University, Baton Rouge 70803.
Baker
J D
JD
Baumeister
A A
AA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004327:Drinking Behavior / Q000187:drug effects* / Q000502:physiology; D007276:Injections, Intraventricular; D008297:Male; D009496:Neurotensin / Q000378:metabolism / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013894:Thirst / Q000187:drug effects*
D010446:Peptide Fragments; D009496:Neurotensin