Comparative investigation of the antiproliferative efficacy of alclometasone.
In this study, the antiproliferative activity of a 0.05% alclometasone ointment (Alc, Delonal) on the epidermis of the mouse tail was investigated. We have found that Alc thins the epidermis to approximately the same extent as hydrocortisone acetate (1%), but has an extremely slighter epidermal thinning effect than betamethasone (betametasone-17,21-dipropionate, 0.064%, Diprosis). The incorporation rate of 3H-thymidine triphosphate into the DNA was inhibited to almost the same extent. In conclusion the small antiproliferative effect of Alc shows no correlating effects compared with its high vasoconstrictory efficacy.
Lubach
D
D
Department of Dermatology (Hautklinik Linden), Medizinische Hochschule Hannover, Fed. Rep. of Germany.
Kietzmann
M
M
Neumann
Y
Y
D000818:Animals; D001623:Betamethasone / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects*; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D004247:DNA / Q000378:metabolism; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D008775:Methylprednisolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D012867:Skin / Q000166:cytology / Q000187:drug effects*; D013936:Thymidine / Q000378:metabolism
D004247:DNA; D001623:Betamethasone; C021137:alclometasone dipropionate; D013936:Thymidine; D006854:Hydrocortisone; D008775:Methylprednisolone