Effect of uremic toxins--guanidino compounds and creatinine--on proliferation of HL60 and K562 cell lines.
Growth of the promyelocytic cell line HL60 and the erythroleukemia cell line K562 is inhibited by 'uremic toxins': creatinine, guanidino propionic acid and guanidino succinic acid in a concentration range similar to that of uremic sera. Among the tested compounds, creatinine exhibits the strongest and most dose-dependent inhibitory effect on both kinds of cells. These results provide a better understanding of the mechanism involved in the anemia of uremic patients.
Nathan
I
I
Department of Hematology, Soroka University Hospital, Beer Sheva, Israel.
Hensel
R
R
Dvilansky
A
A
Shainkin-Kestenbaum
R
R
D002460:Cell Line; D003404:Creatinine / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000494:pharmacology; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute; D015473:Leukemia, Promyelocytic, Acute; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014511:Uremia / Q000503:physiopathology
D006131:Growth Inhibitors; D006146:Guanidines; D003404:Creatinine