[Aldehyde dehydrogenase activity in rat cerebral structures].
By means of the quantitative histochemical method aldehyde dehydrogenase (AldDG; acidic phosphatase 1.2.1.3.) activity has been studied in neuronal structures of all parts of the rat CNS. The greatest activity has been revealed in cytoplasm of receptor (nucleus of the mesencephalic tract trigeminal nerve-1,100 stipulated units) and effector (all motor nuclei of the trunk and spinal cord: 500-800 stipulated units) cerebral neurons. In perikaryons and axons of most of the intercalated neurons AldDG activity is not great (200-300 stipulated units). A positive correlation is found between distribution of AldDG activity among the forebrain structures, on the one hand, and density of dopaminergic terminals, dopamine content and MAO activity of these structures--on the other. In the metencephalon similar correlation is found between AldDG activity and noradrenaline content and density of serotoninergic terminals. A direct dependence is stated of AldDG activity on phylogenic age of the cerebral structures. The data presented demonstrate that AldDG activity is connected with those cerebral structures that are supposed to possess, in the process of common and mediatory metabolism, a high level of natural synthesis of aldehydes.
Zimatkin
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D000444:Aldehyde Dehydrogenase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D006651:Histocytochemistry; D008297:Male; D009474:Neurons / Q000201:enzymology; D051381:Rats
D000444:Aldehyde Dehydrogenase
Aktivnost' al'degiddegidrogenazy v strukturakh mozga krysy.