Effect of brain gangliosides on early and late consequences of a transient incomplete forebrain ischemia in the rat.
Rat transient incomplete forebrain ischemia was induced by 60 min of bilateral carotid artery occlusion associated with systemic hypotension. Intraperitoneal treatment with either GM-1 monosialoganglioside or its inner ester AGF-2 started 1 h after release of carotid clamps and was repeated twice a day. Ganglioside treatment was effective in reducing the increase of cerebral water content, nonetheless AGF-2 reduces significantly not only cerebral edema, but also potassium efflux and calcium overload. With respect to ischemic untreated rats, GM-1- and AGF-2-treated rats showed a higher incidence of conditioned response retention of a single training trial, associated with improvement in cerebral blood flow and electrocorticographic patterns. In addition, 4 weeks following ischemia, the extent of tissue necrosis was reduced, although not statistically significant, in both ganglioside-treated groups. However, all these improvements are more evident in the AGF-2-treated rats than in the GM-1-treated ones. In conclusion, these results suggest that, except in some cases with different potency, both monosialoganglioside GM-1 and its inner ester derivative, AGF-2, are able to improve outcome after brain ischemia.
Borzeix
M G
MG
Department of Experimental Therapeutics SIR International, Montrouge, France.
Cahn
R
R
Cahn
J
J
D000818:Animals; D001921:Brain / Q000503:physiopathology; D001923:Brain Chemistry / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism; D002412:Cations / Q000134:cerebrospinal fluid / Q000378:metabolism; D003216:Conditioning, Operant / Q000187:drug effects; D004569:Electroencephalography; D005732:Gangliosides / Q000502:physiology*; D002546:Ischemic Attack, Transient / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D009336:Necrosis / Q000503:physiopathology; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014867:Water / Q000134:cerebrospinal fluid / Q000378:metabolism
D002412:Cations; D005732:Gangliosides; D014867:Water; D011188:Potassium; D002118:Calcium