The distribution and retention of 89Sr in mice after a single intravenous injection of high and low doses.
Female C3H/He mice, aged 12-17 weeks, were injected intravenously with 89SrCl2 at doses of 0.74kBq g-1 body weight (low dose) or 74.0kBq g-1 (high dose). During the first week after injection, approximately 45% of the injected 89Sr was excreted in the urine and feces in both dose groups. The excretion of 89Sr decreased thereafter. The total excretion up to 56 days after injection was 63.0% and 64.5% of the injected dose in the high and low dose groups, respectively. There was no significant difference in the excretion of 89Sr in the urine between the two groups, while the fecal excretion in the low dose group was slightly higher than in the high dose group. The retention of 89Sr in the right and left femurs was 1.30 and 1.46% of the injected dose on day 7, which decreased to 0.64 and 0.70% on day 56, in the high and low dose groups, respectively. No significant difference was observed in bone retention of 89Sr between the two groups. The amount of 89Sr distributed to the soft tissues was very small and became undetectable by 42 days after injection.
Takahashi
S
S
Oghiso
Y
Y
Sato
H
H
Kubota
Y
Y
D000818:Animals; D005260:Female; D007275:Injections, Intravenous; D051379:Mice; D008809:Mice, Inbred C3H; D011829:Radiation Dosage; D013324:Strontium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013326:Strontium Radioisotopes / Q000008:administration & dosage; D014018:Tissue Distribution
D013326:Strontium Radioisotopes; C025700:strontium chloride; D013324:Strontium