title: Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization.
abstract: Human class I alcohol dehydrogenase (alcohol:NAD+ oxidoreductase, EC 1.1.1.1; ADH) is the major enzyme involved in ethanol oxidation. Three highly homologous genes govern the synthesis of three types of subunits which form several ADH isozymes. The locus for class I ADH loci was previously assigned to q21-25 of chromosome 4 by somatic cell hybridization techniques. Analysis of grain positions by in situ hybridization of chromosomes indicated that the ADH cluster locus is on 4q21-23, probably 4q22.
authors.affiliation: Department of Biochemical Genetics, Beckman Research Institute of the City of Hope, Duarte, California 91010.
authors.forename: M
authors.initials: M
authors.lastname: Tsukahara
authors.forename: A
authors.initials: A
authors.lastname: Yoshida
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D008677:Metaphase; D008722:Methods; D005810:Multigene Family; D009693:Nucleic Acid Hybridization
chemical_list: D000426:Alcohol Dehydrogenase