5-Carboxyamidotryptamine mimics only the 5-HT elicited hyperpolarization of hippocampal pyramidal cells via 5-HT1A receptor.
Perfusion of the rat hippocampal slice in vitro by 5-hydroxytryptamine (5-HT) elicits 3 distinct actions recorded intracellularly from pyramidal cells in area CA1: a hyperpolarization, reduction in spike train elicited afterhyperpolarization (AHP) and depolarization. 5-Carboxyaminotryptamine (5-CT) mimics the membrane hyperpolarization elicited by 5-HT through its action on the 5-HT1A receptor; however, 5-CT does not mimic 5-HT in reducing the amplitude of the AHP or the depolarization of membrane potential. The hyperpolarizing effect of 5-CT is blocked by spiperone. These data provide evidence that the inhibitory effect of 5-HT is mediated primarily by the 5-HT1A receptor.
Beck
S G
SG
Department of Pharmacology, Mount Sinai School of Medicine of CUNY, NY 10029.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D011985:Receptors, Serotonin; D012701:Serotonin; C047087:5-carboxamidotryptamine