Anti-coccidial activity of human milk.
Sporozoites of Eimeria tenella, an important pathogen of poultry, were killed in vitro in a time- and concentration-dependent manner by exposure to diluted concentrations of normal human milk. Sodium cholate (bile salt stimulator) potentiated the anti-coccidial activity. The anti-coccidial activity was not found in the milk of lower mammals (cow, sheep, goat, dog). The component in human milk showing the activity was initially hypothesized to be a bile salt-stimulated lipase. However, testing of purified lipase (with or without sodium cholate) indicated no anti-coccidial activity. Consequently, we theorize that the active component may be a free fatty acid.
Folz
S D
SD
Upjohn Company, Kalamazoo, MI 49001.
Lee
B L
BL
Nowakowski
L H
LH
Winterrowd
C A
CA
Conder
G A
GA
D000818:Animals; D002417:Cattle; D004285:Dogs; D004539:Eimeria / Q000276:immunology*; D006041:Goats; D006801:Humans; D008892:Milk / Q000276:immunology; D008895:Milk, Human / Q000276:immunology*; D012756:Sheep