Effect of neostigmine on metoclopramide-induced aldosterone secretion in man.
This study examines the role of a neostigmine-induced increase in acetylcholine on the aldosterone stimulating effect of metoclopramide. Six normal male volunteers received the following three treatments in a cross-over randomized sequence: neostigmine, 0.5 mg s.c.; metoclopramide 10 mg i.v.; and neostigmine 0.5 mg s.c., followed by metoclopramide 10 mg i.v. Metoclopramide increased serum aldosterone significantly to 161% of basal level at 15 min. With neostigmine aldosterone levels peaked (129%) significantly at 30 min. In the presence of neostigmine, however, the metoclopramide-induced aldosterone response was blunted significantly. These results would suggest that presynaptic autoreceptors depresses the continued output of acetylcholine, thereby blunting the aldosterone responses to metoclopramide significantly.
Sommers
D K
DK
Department of Pharmacology, Universiteit van Pretoria, South Africa.
Meyer
E C
EC
van Wyk
M
M
D000328:Adult; D000450:Aldosterone / Q000378:metabolism*; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D009388:Neostigmine / Q000494:pharmacology*; D011863:Radioimmunoassay; D011897:Random Allocation
D007457:Iodine Radioisotopes; D009388:Neostigmine; D000450:Aldosterone; D008787:Metoclopramide