Effect of halothane on metabolic ATP and induced aggregation of human blood platelets.
The general anaesthetic halothane decreases both the metabolic ATP level and the aggregability of blood platelets. Evaluation of the dose dependence of these halothane effects reveals that the loss of aggregability is not the direct result of an impaired energy metabolism.
Hofmann
J G
JG
Institute of Pathological Biochemistry, Medical Academy of Erfurt, GDR.
Seidel
U
U
Till
U
U
D000227:Adenine Nucleotides / Q000097:blood; D000255:Adenosine Triphosphate / Q000097:blood*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors
D000227:Adenine Nucleotides; D010975:Platelet Aggregation Inhibitors; D000255:Adenosine Triphosphate; D006221:Halothane