Maintenance of metabolic alkalosis despite saline administration in the presence of ascites.
The administration of more than 15 L of saline over 10 days did not correct the metabolic alkalosis (plasma total CO2 35 mEq/L) of a patient with ascites secondary to ovarian carcinoma. Weight gain was more than 6 kg and urine chloride concentration remained less than 15 mEq/L. The tubular avidity for chloride and sodium which maintains metabolic alkalosis persisted in the face of saline administration, perhaps because of "ineffective" volume expansion.
Weizman
H B
HB
Kahn
T
T
D000230:Adenocarcinoma / Q000150:complications; D000471:Alkalosis / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D001201:Ascites / Q000209:etiology*; D002648:Child; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000150:complications; D012965:Sodium Chloride / Q000627:therapeutic use*
D012965:Sodium Chloride