title: Dominantly inherited cleft lip and palate in two families.
abstract: Two families with non-syndromic cleft lip and cleft palate are described. The linear pattern of inheritance through several generations is difficult to explain by conventional multifactorial models. The pedigrees strengthen the suggestion that a dominantly inherited mutation exists with a major influence on clefting of the lip and palate alone.
authors.affiliation: Department of Paediatric Genetics, Institute of Child Health, London.
authors.forename: K
authors.initials: K
authors.lastname: Temple
authors.forename: M
authors.initials: M
authors.lastname: Calvert
authors.forename: D
authors.initials: D
authors.lastname: Plint
authors.forename: E
authors.initials: E
authors.lastname: Thompson
authors.forename: M
authors.initials: M
authors.lastname: Pembrey
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002971:Cleft Lip / Q000150:complications / Q000235:genetics*; D002972:Cleft Palate / Q000150:complications / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010375:Pedigree