[The immunotropic activity of GABA during cytochrome P-450 induction in the liver].
Gamma-aminobutyric acid (GABA) was shown to exert the immunodepressive effect. The use of GABA under induction of cytochrome P-450 of the liver by phenobarbital or rifampicin was not followed by immunodepression. The obtained data indicate the dependence of GABA pharmacological activity from the function of cytochrome P-450-dependent monooxygenase system of the liver.
Kovalev
I E
IE
Riabinina
N E
NE
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D004912:Erythrocytes / Q000276:immunology; D006591:Hexobarbital / Q000494:pharmacology; D007114:Immunization; D007166:Immunosuppressive Agents; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D010634:Phenobarbital / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D005680:gamma-Aminobutyric Acid; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D012293:Rifampin; D010634:Phenobarbital
Immunotropnaia aktivnost' GAMK v usloviiakh induktsii tsitokhroma P-450 v pecheni.