[Antihypoxic and antioxidative properties of bemitil].
The authors discovered antihypoxic properties of the bemitil (pretreatment injections 50 mg/kg intraperitoneally) in the experiments on rats with the circulatory or hypoxic hypoxia. There was limitation of pO decrease and diene conjugates and Schiff bases production increase with the drug in the circulatory hypoxia conditions. Bemitil restricted malondialdehyde accumulation in the rat brain homogenate under the activation of free radicals processes. In the mitochondrial suspension incubation similar effect of the medicine was accompanied with limitation of organelle degradation. Bemitil showed no antiradical activity.
Plotnikov
M B
MB
Saratikov
A S
AS
Plotnikova
T M
TM
Khazanov
V A
VA
Panina
O P
OP
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001237:Asphyxia / Q000188:drug therapy / Q000503:physiopathology; D001562:Benzimidazoles / Q000627:therapeutic use*; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D004353:Drug Evaluation, Preclinical; D004569:Electroencephalography; D005260:Female; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000975:Antioxidants; D001562:Benzimidazoles; C049825:bemethyl
Antigipoksicheskie i antiokislitel'nye svoĭstva bemitila.