A prospective study of immunoglobulin changes in relation to human immunodeficiency virus infection in a cohort of homosexual men.
Changes in IgG levels and patterns in association with human immunodeficiency virus, (HIV) infection were characterized in a prospective investigation by studying serum electrophoresis and antibodies to HIV at least once a year in 144 homo/bisexual (HS) men during a 4-year period. Initially, 25 men (17.4%) were HIV-positive, and this increased to 44 at the end of the study period. HIV-negative men had IgG levels of 11.2 +/- 2.2 g/l. In the 19 HIV seroconverters the mean IgG level rose with time according to the equation IgG = 0.054x + 12.56 (x = months after the last HIV-negative test). Oligoclonal IgG bands were found in three of the 19 seroconverters (16%) prior to conversion and in 2/16 (13%), 5/13 (38%), 7/11 (64%), and 3/8 (38%) 1, 2, 3, and 4 years after conversion, respectively. Of the 25 initially HIV-positive men, five have developed acquired immunodeficiency syndrome (AIDS) during the 4.5 year follow-up. At the first investigation these five men had higher mean IgG levels (16.0 +/- 2.7 g/l) than the 20 men who have remained healthy (14.6 +/- 2.8 g/l), and all five had oligoclonal bands as compared to 9/20 of those who did not develop AIDS. Oligoclonal IgG bands reflect the IgG increase and seem to indicate long-standing HIV infection and a poor prognosis.
Bratt
G
G
Department of Dermatology and Venereology, Södersjukhuset, Stockholm, Sweden.
Waldenlind
L
L
Von Krogh
G
G
Karlsson
A
A
Moberg
L
L
Biberfeld
G
G
Sandström
E
E
D000386:AIDS-Related Complex / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000293:Adolescent; D000328:Adult; D015483:HIV Antibodies / Q000096:biosynthesis*; D006679:HIV Seropositivity / Q000276:immunology*; D006716:Homosexuality; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis*; D007136:Immunoglobulins / Q000032:analysis / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D043025:Oligoclonal Bands; D011446:Prospective Studies
D015483:HIV Antibodies; D007074:Immunoglobulin G; D007136:Immunoglobulins; D043025:Oligoclonal Bands