Effect of Ginkgo biloba extract on microsomal enzyme induction.
Twenty-four healthy volunteers were divided in three groups who were randomly assigned different treatments for 13 days: group I received 400 mg/day of a defined Ginkgo biloba extract (GBE), group II 300 mg/day of phenytoin and group III a placebo. The elimination half-life of antipyrine was measured with a high performance liquid chromatographic technique initially and on the last day of the administration of the treatments. The results show that the half-life of antipyrine was not affected by GBE and placebo treatments, whereas it was significantly decreased (p less than 0.05) frm 12.2 to 6.8 h after phenytoin control treatment. This study demonstrates that GBE has no effect on the hepatic microsomal drug oxidation system.
Duche
J C
JC
Laboratoire Hospitalo-Universitaire de Pharmacologie, Centre Hospitalier Intercommunal, Creteil, France.
Barre
J
J
Guinot
P
P
Duchier
J
J
Cournot
A
A
Tillement
J P
JP
D000328:Adult; D000983:Antipyrine / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D006207:Half-Life; D006801:Humans; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010672:Phenytoin / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*
D010936:Plant Extracts; D010672:Phenytoin; D000983:Antipyrine