[The efficacy and tolerance of ivermectin (Mectizan) prescribed for the patient with multiple filarial infections (Loa loa/Onchocerca and/or M. perstans)].
Administration of ivermectin (Mectizan) in Loa loa filariasis induces a significant decrease of microfilaria load within 3 to 15 days. The excellent tolerability of the drug in patients infested simultaneously by O. volvulus and Loa loa allows to use ivermectin in mass treatments in geographical areas where the same patients can be affected by several filariasis. There is almost no efficacy against Mansonella perstans. A second administration one month after the first one in Loa loa affected patients has not led to a complete disappearance of microfilaria; the tolerability has still been good. Efficacy on Ascaris lumbricoides appears to be excellent; further studies are necessary in the cases of trichuriasis, ancylostomiasis and strongyloidiasis.
Richard-Lenoble
D
D
Departement de Parasitologie-Mycologie-Médecine tropicale, Centre Universitaire des Sciences de la Santé (CUSS), Libreville, Gabon.
Kombila
M
M
Chandenier
J
J
Gaxotte
P
P
D005368:Filariasis / Q000188:drug therapy*; D006801:Humans; D007559:Ivermectin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008118:Loiasis / Q000150:complications / Q000188:drug therapy*; D008368:Mansonelliasis / Q000150:complications / Q000188:drug therapy*; D009855:Onchocerciasis / Q000150:complications / Q000188:drug therapy*
D007559:Ivermectin
Efficacité et tolérance de l'ivermectine (Mectizan) prescrit chez le sujet multifilarien (Loa loa/onchocercose et/ou M. perstans).