[Effect of lignins and their model compounds on amine nitrosation in a human gastric juice medium and in the body of mice].
The study was concerned with the influence of lignins of leaf-bearing and coniferous timber and 22 model compounds (lignin components) on nitrosation of dimethylamine, amidopyrine and morpholine in human gastric juice. Some results of the study were confirmed in murine experiments. Compounds of the guaiacyl series showed the highest inhibitory activity. Lignins of coniferous timber proved most effective.
Ermilov
V B
VB
Sultanov
V S
VS
Shendrikova
I A
IA
Dikun
P P
PP
D000818:Animals; D003864:Depression, Chemical; D005750:Gastric Juice / Q000187:drug effects* / Q000378:metabolism; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008031:Lignin / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D009573:Nitrites / Q000378:metabolism; D009602:Nitrosamines / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013329:Structure-Activity Relationship
D009573:Nitrites; D009602:Nitrosamines; D006139:Guaiacol; D008031:Lignin
Vliianie ligninov i nekotorykh ikh model'nykh soedineniĭ na nitrozirovanie aminov v srede zheludochnogo soka cheloveka i v organizme mysheĭ.