title: [The use of buprenorphine in the postoperative period in heart surgery. Evaluation of its efficacy and tolerance].
abstract: Twenty patients were studied in the early post-operative period after cardiac surgery with sternotomy. Buprenorphine was prescribed: 0.3 mg intra-muscularly after total recovery from anaesthesia (8th hour) then every 8 hours if requested during 72 hours. The patients auto-estimated their level of analgesia, the clinical effects were measured with regard to heart rate, systolic and diastolic arterial pressure, and respiratory rate, before, 2 and 4 hours after each injection. Buprenorphine administration produces an effective, long lasting (8 to 12 hours) analgesia. No significant changes in haemodynamic or respiratory parameters were noticed. Side effects occurred rarely: 5 cases of drowsiness, reversible by verbal stimulation, 2 of nausea and sweats, 2 retentions of urine (after vesical catheter withdrawal). Parenteral buprenorphine is satisfactory for treatment of severe thoracic pain due to sternotomy, although the oral route would be safer during effective anticoagulant treatment.
authors.affiliation: Département d'Anesthésie-Réanimation chirurgicale, Hôpital Broussais, Paris.
authors.forename: S
authors.initials: S
authors.lastname: Grill
authors.forename: C
authors.initials: C
authors.lastname: Lasalle
authors.forename: M T
authors.initials: MT
authors.lastname: Cousin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002047:Buprenorphine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D012646:Self Administration; D013249:Sternum / Q000601:surgery
chemical_list: D002047:Buprenorphine
vernacular_title: Utilisation de la buprénorphine dans la période post-opératoire en chirurgie cardiaque. Evaluation de l'efficacité et de la tolérance.