title: The ultrastructure of nuclear inclusions in the giant-cell tumor of bone.
abstract: The ultrastructural study of three cases of giant-cell tumor of bone showed two types of nuclear inclusions. The first type, common to giant cells and stromal cells was granular, and sometimes associated with a fibrillar pattern observed only in giant cells. The second type was represented by nuclear bodies, encountered mostly in the stromal cells. The nuclear bodies were made up of a granular core enveloped in a multilayered coat. The nature of these nuclear inclusions might be viral and thus a viral pathogenesis of the giant-cell tumor of bone is discussed.
authors.affiliation: Department of Electron Microscopy, V. Babes Institute, Bucharest, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Negoescu
authors.forename: E
authors.initials: E
authors.lastname: Mandache
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000648:ultrastructure*; D002467:Cell Nucleus / Q000648:ultrastructure*; D005870:Giant Cell Tumors / Q000648:ultrastructure*; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged