title: [Thyroid hormone anomalies in patients with insulin-dependent diabetes mellitus and circulating antithyroid microsomal antibodies].
abstract: In insulin-dependent diabetes mellitus (IDDM) several organ-specific autoantibodies are found in addition to pancreatic islet cell autoantibodies. In the present study we researched the presence of thyroid microsomal antibodies (anti-TMS) in 33 young patients with IDDM and evaluated contemporaneously their thyroid function. 5 patients (15.4%) are found with significant levels of circulating anti-TMS, among them 4 (12.1%) were also subclinical hypothyroid. However 6 other patients are found with mildly altered thyroid hormone pattern in absence of circulating anti-TMS. Basal and TRH-stimulated TSH were significantly higher, whereas serum FT4 was significantly lower, in patients with IDDM and circulating anti-TMS than in patients with IDDM but without anti-TMS. These observations indicate a significant incidence of mild or subclinical hypothyroidism in patients with IDDM and anti-TMS. Thus the screening for anti-TMS is recommended in all patients with IDDM, then thyroid hormone pattern of anti-TMS positive patients must be periodically followed.
authors.affiliation: Università degli Studi di Palermo, Cattedra di Patologia Medica I.
authors.forename: N
authors.initials: N
authors.lastname: Custro
authors.forename: V
authors.initials: V
authors.lastname: Scafidi
authors.forename: G
authors.initials: G
authors.lastname: Costanzo
authors.forename: D
authors.initials: D
authors.lastname: Casiglia
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008861:Microsomes / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood*
chemical_list: D001323:Autoantibodies; D013972:Thyrotropin; D013974:Thyroxine
vernacular_title: Anomalie ormonali tiroidee in pazienti con diabete mellito insulino-dipendente ed anticorpi antitiroidei microsomiali in circolo.