Total small bowel resection inhibited bombesin-stimulated release of cholecystokinin and pancreatic polypeptide in anesthetized cats.
In anesthetized cats, immunoreactive cholecystokinin (CCK), pancreatic polypeptide (PP), and gastrin were released in response to bombesin both before and after small bowel resection. Total small bowel resection significantly decreased bombesin-stimulated release of cholecystokinin and pancreatic polypeptide without affecting the release of gastrin. Integrated analysis showed that CCK, pancreatic polypeptide, and gastrin were released in significant quantities after small bowel resection. The results show that total small bowel resection caused significant inhibition of bombesin-stimulated release of cholecystokinin and pancreatic polypeptide; in contrast, gastrin release remained unaffected. The data further indicate that extra bowel sources of cholecystokinin exist in cats and the release of CCK from those sources occurred following bombesin stimulation.
Inoue
K
K
First Department of Surgery, Kyoto University, Japan.
Chowdhury
P
P
Hosotani
R
R
McKay
D
D
Ami
M
M
Rayford
P L
PL
D000758:Anesthesia; D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D002415:Cats; D002766:Cholecystokinin / Q000097:blood / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D007421:Intestine, Small / Q000502:physiology*; D009994:Osmolar Concentration; D010191:Pancreatic Polypeptide / Q000097:blood / Q000378:metabolism*; D011863:Radioimmunoassay
D005755:Gastrins; D010191:Pancreatic Polypeptide; D002766:Cholecystokinin; D001839:Bombesin