title: A tool for multiple sequence alignment.
abstract: Multiple sequence alignment can be a useful technique for studying molecular evolution and analyzing sequence-structure relationships. Until recently, it has been impractical to apply dynamic programming, the most widely accepted method for producing pairwise alignments, to comparisons of more than three sequences. We describe the design and application of a tool for multiple alignment of amino acid sequences that implements a new algorithm that greatly reduces the computational demands of dynamic programming. This tool is able to align in reasonable time as many as eight sequences the length of an average protein.
authors.affiliation: Mathematical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20894.
authors.forename: D J
authors.initials: DJ
authors.lastname: Lipman
authors.forename: S F
authors.initials: SF
authors.lastname: Altschul
authors.forename: J D
authors.initials: JD
authors.lastname: Kececioglu
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D002918:Chymotrypsin / Q000235:genetics; D008962:Models, Theoretical; D008969:Molecular Sequence Data; D010196:Pancreatic Elastase / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D012984:Software; D013552:Swine; D014357:Trypsin / Q000235:genetics
chemical_list: D011506:Proteins; D002918:Chymotrypsin; D010196:Pancreatic Elastase; D014357:Trypsin