[Parkinson syndrome after administration of acetylcholine into the caudate nuclei].
Rats with the Parkinsonian syndrome induced by administration of acetyl choline and proserine into the rostral part of both caudate nuclei manifest an increased electrical activity (EA) in this part. Tremor, oligokinesia and rigidity are characterized by the appearance of paroxysmal EA with high amplitude of slow and rapid waves. The data obtained allow to conclude that neuropathophysiological basis of the Parkinsonian syndrome is the formation of the generator of pathologically enhanced excitation (GPEE) in the caudate nuclei. Some peculiarities of the GPEE activity in tremor and akinetic rigidity syndromes were observed. Intrarostral administration of dopamine or intraperitoneal administration of cyclodol resulted in the inhibition of GPEE and disappearance of clinical manifestations of Parkinsonian syndrome.
Kryzhanovskiĭ
G N
GN
Atadzhanov
M A
MA
Voronina
T A
TA
Nerobkova
L N
LN
D000109:Acetylcholine / Q000008:administration & dosage*; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects* / Q000503:physiopathology; D004195:Disease Models, Animal; D004298:Dopamine / Q000008:administration & dosage; D004567:Electrodes, Implanted; D004569:Electroencephalography; D007274:Injections, Intraperitoneal; D008297:Male; D008845:Microinjections; D009388:Neostigmine / Q000008:administration & dosage; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D014282:Trihexyphenidyl / Q000008:administration & dosage
D009388:Neostigmine; D014282:Trihexyphenidyl; D000109:Acetylcholine; D004298:Dopamine
Sindrom Parkinsona posle vvedeniia atsetilkholina v khvostatye iadra.