title: Adenocarcinoma of the stomach: a multivariate analysis of clinical, pathologic and treatment factors.
abstract: We performed a retrospective prognostic study of 246 patients treated for adenocarcinoma of the stomach with curative intent over the period 1960-1984. Lesions of the cardia and gastro-esophageal junction were excluded. The study examined the prognostic influence of nine clinicopathologic and six treatment variables by univariate and multivariate analysis. Five-year survival rates (Kaplan-Meier) for TNM stages, IA, IB, II, IIIA, and IIIB were 88%, 80%, 55%, 30% and 9%, respectively. The Cox models of proportional hazards identified five independent variables predictive of death from gastric cancer: high TNM stage, metastatic involvement of four or more regional lymph nodes, poor differentiation of tumor, splenectomy and insufficient scope of regional lymph-adenectomy relative to the nodal stage (R minus N less than 1.5).
authors.affiliation: Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York.
authors.forename: M H
authors.initials: MH
authors.lastname: Shiu
authors.forename: M
authors.initials: M
authors.lastname: Perrotti
authors.forename: M F
authors.initials: MF
authors.lastname: Brennan
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000469:parasitology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D013223:Statistics as Topic; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D013997:Time Factors