Chronic myeloid leukemia with monoclonal gammopathy terminating in myeloid crisis and immunoblastic lymphoma.
A patient, with chronic myeloid leukemia and IgA monoclonal gammopathy, who contemporaneously developed myeloid blast crisis and immunoblastic lymphoma is reported. Cytogenetic studies showed complex chromosome abnormalities concerning chromosomes 8, 14 and 22, other than the Ph chromosome. A possible relationship between the emergence of immunoblasts from slow proliferating lymphoplasmacytoid cells, myeloid blasts crisis and chromosomal changes is discussed.
Larocca
L M
LM
Instituti di Anatomia Patologica, Università Cattolica del S. Cuore, Roma, Italy.
Zollino
M
M
Carbone
A
A
Eboli
M L
ML
Mango
G
G
Leone
G
G
D001752:Blast Crisis / Q000209:etiology*; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000235:genetics / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology*; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications* / Q000235:genetics
D007070:Immunoglobulin A