title: Circulating levels of placental protein 14 and progesterone following Mifepristone (RU38486) and Gemeprost for termination of first trimester pregnancy.
abstract: Ten patients underwent successful termination of first trimester pregnancies with RU38486 (Mifepristone, Roussel Laboratories Ltd., Broadwater Park, Uxbridge, Middlesex, United Kingdom) followed 2 days later by a prostaglandin (Gemeprost, May and Baker Ltd., Dagenham, Essex, United Kingdom) pessary. Four hours after administration of RU38486, the levels of progesterone (P) started to fall and continued to show a gradual decline until the abortion was completed, when a steep fall to follicular phase values was observed. Levels of placental protein 14 remained unaltered until 2 days after RU38486 administration, when levels were increased. The rise in placental protein 14 in association with falling P concentrations suggests that the decidual secretion of placental protein 14 might be independent of P. Fertil Steril 52:66, 1989.
authors.affiliation: St. Bartholomew's Hospital Medical College, London Hospital Medical College, United Kingdom.
authors.forename: R J
authors.initials: RJ
authors.lastname: Howell
authors.forename: F
authors.initials: F
authors.lastname: Olajide
authors.forename: B
authors.initials: B
authors.lastname: Teisner
authors.forename: G
authors.initials: G
authors.lastname: Grudzinskas
authors.forename: T
authors.initials: T
authors.lastname: Chard
mesh_terms: D000019:Abortifacient Agents / Q000008:administration & dosage*; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage*; D000028:Abortion, Induced / Q000379:methods*; D000527:Alprostadil / Q000008:administration & dosage / Q000031:analogs & derivatives; D004963:Estrenes / Q000008:administration & dosage; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins; D006801:Humans; D015735:Mifepristone; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D011261:Pregnancy Trimester, First; D011374:Progesterone / Q000097:blood*
chemical_list: D000019:Abortifacient Agents; D000021:Abortifacient Agents, Steroidal; D004963:Estrenes; D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins; D015735:Mifepristone; C021182:gemeprost; D011374:Progesterone; D000527:Alprostadil