Serum and tissue total sialic acid as a marker for human thyroid cancer.
In this study, serum and tissue sialic acid levels in various histopathological types of thyroid cancer were measured and were found to be significantly higher than those measured in the control group. The amount of sialic acid in tissue was 2.8 +/- 1.42 mg/100 mg protein while the serum level was 79.2 +/- 6.6 mg per dl. The rise in tissue and serum sialic acid levels was relatively non-specific with respect to type of cancer as they depend on the tumor burden only. Neither were they related to age, sex or duration of cancer. The serum sialic acid levels increased during the few days following thyroidectomy and returned to normal thereafter. The sialic acid determination appeared to be an important criterion in patient follow-up and evaluating therapeutic response.
Kökoğlu
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E
Department of Biochemistry, Cerrahpasa Medical Faculty, University of Istanbul, Turkey.
Uslu
E
E
Uslu
I
I
Hatemi
H H
HH
D000230:Adenocarcinoma / Q000032:analysis*; D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D002277:Carcinoma / Q000032:analysis*; D002291:Carcinoma, Papillary / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid; D012794:Sialic Acids / Q000032:analysis* / Q000097:blood; D013964:Thyroid Neoplasms / Q000032:analysis* / Q000097:blood / Q000473:pathology; D013965:Thyroidectomy
D014408:Biomarkers, Tumor; D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid