title: Acute alcohol intoxication paired with appetitive reinforcement: effects upon ethanol intake in infant rats.
abstract: A recent study suggested that infant rats process alcohol odor and/or taste during acute ethanol intoxication probably due to ethanol elimination via respiration and salivation. The present set of experiments was meant to analyze the possibility that this orosensory processing may act as a conditioned stimulus when an appetitive reinforcer is paired with the state of intoxication. In the first experiment it was observed that intragastric administration of a mildly intoxicating ethanol dose (1.5 g/kg), paired during postabsorptive time intervals with oral infusion of sucrose, was sufficient to promote a significant preference to ethanol. In Experiment 2 different doses of ethanol were either paired or explicitly unpaired with sucrose administration. The result reported in Experiment 1 was replicated and it was observed that a higher dose (3.0 g/kg) unpaired with the reinforcer resulted in alcohol aversions in terms of alcohol consumption patterns. However, when the reinforcer was paired with this dose, the aversion was inhibited. Finally, in the third experiment results indicated that preexposure to alcohol odor eliminates sucrose-conditioned alcohol preferences. These results indicate that, in physiologically immature rats, alcohol preference can be regulated by prior associative experiences involving the state of intoxication and consequences internal and/or inherent to this state.
authors.affiliation: Instituto de Investigacion Medica Mercedes y Martin Ferreyra, Cordoba, Argentina.
authors.forename: J C
authors.initials: JC
authors.lastname: Molina
authors.forename: M G
authors.initials: MG
authors.lastname: Chotro
mesh_terms: D000428:Alcohol Drinking / Q000523:psychology*; D000435:Alcoholic Intoxication / Q000523:psychology*; D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects; D001245:Association Learning / Q000187:drug effects; D001362:Avoidance Learning / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D003463:Cues; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D007858:Learning / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012903:Smell / Q000187:drug effects; D013649:Taste / Q000187:drug effects
chemical_list: D000431:Ethanol