The development in infant rats of kassinin's potent and selective control of cell-dehydration thirst.
In infant rats, kassinin exerts its antidipsogenic effect in the very early stages of neonatal life (2nd-3rd day). The inhibition of cell-dehydration drinking appears in rats of 2 days, and attains adult levels in pups of 9 days. Instead, the thirsts induced by suckling deprivation or by intracerebroventricular angiotensin II are inhibited by kassinin precociously (3rd day), but are unaffected by it in rats of 12-15 days. Kassinin also inhibits milk intake very early (3rd day) and this effect also disappears at 12 days of age. The pattern of ontogenetic results described here may be that of a brain kassinin-like tachykinin that, in the course of the development of the neural structures on which it acts, gains potent and selective control of cell-dehydration thirst.
Perfumi
M
M
Institute of Pharmacology, University of Camerino, Italy.
Massi
M
M
Costa
G
G
Epstein
A N
AN
de Caro
G
G
D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology; D003681:Dehydration / Q000503:physiopathology*; D004327:Drinking Behavior / Q000187:drug effects*; D005260:Female; D007276:Injections, Intraventricular; D015286:Kassinin / Q000494:pharmacology*; D008297:Male; D008892:Milk; D051381:Rats; D012527:Satiation / Q000187:drug effects; D013894:Thirst / Q000187:drug effects*; D014868:Water Deprivation
D000804:Angiotensin II; D015286:Kassinin