Heterologous antibody responses of calves to Anaplasma centrale and A. marginale.
Antigens of Anaplasma centrale, Onderstepoort isolate, and A. marginale, Wacol isolate, were analysed by a Western blotting technique. Sera from A. centrale-infected calves reacted to 41- and 38-kDa antigens in A. centrale and a 41-kDa antigen in A. marginale. Serum collected during the primary reaction from an A. marginale-infected calf reacted only to the 41-kDa antigen of A. marginale; heterologous antibody response to the 41-kDa antigen of A. centrale did occur later during the infection, but remained markedly weaker than the homologous response. The serologic cross-reactivity to this 41-kDa Anaplasma antigen confirms that it is common to the genus and also that it is a heterogeneous complex.
Adams
J H
JH
Department of Parasitology, University of Queensland, St. Lucia, Australia.
Shiels
I A
IA
de Vos
A J
AJ
D000709:Anaplasma / Q000276:immunology*; D000712:Anaplasmosis / Q000276:immunology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000942:Antigens, Bacterial / Q000032:analysis* / Q000276:immunology; D015153:Blotting, Western; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D003429:Cross Reactions; D007106:Immune Sera / Q000276:immunology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007106:Immune Sera