The protective mechanism of FPL55712 against stress-induced gastric ulceration in rats.
Cold-restraint stress produced stomach ulceration which was accompanied by a decreased glandular mucosal mast cell count and blood flow. Pretreatment with FPL55712, a leukotriene antagonist, dose-dependently prevented ulcer formation and mast cell depletion; however, it did not affect the reduced mucosal blood flow, nor did it significantly influence acid secretion and pepsin output. The role of the leukotrienes in stress ulceration is discussed in the light of the findings with FPL55712 on gastric glandular mucosal mast cell degranulation.
Ogle
C W
CW
Department of Pharmacology, Faculty of Medicine, University of Hong Kong.
Cho
C H
CH
D000818:Animals; D002867:Chromones / Q000494:pharmacology / Q000627:therapeutic use*; D003080:Cold Temperature; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000517:prevention & control / Q000523:psychology*; D013315:Stress, Psychological / Q000150:complications*
D002867:Chromones; C006312:FPL 55712