[Effect of fenibut on the fetus and newborn infant after the treatment of gestoses].
A total of 78 pregnant females treated for late gestoses with phenibute (a tranquilizing nootropic preparation) were investigated. It was orally administered to pregnant females in a dose of 3.0-3.5 mg/kg/b.w. thrice a day for 6 days or to women in labor as 6.-7.0 mg/kg singularly. Fetus status was assessed with the use of cardiotocography and cardiointervalography. Positive fetotropic effect of phenibute resulted in the improvement of fetal CNS, optimization of its functional activity coordinating cardiac and respiratory performance, elimination or partial reduction of intrauterine hypoxia. A single-dosed effect was rapid and lasted for about 5 hrs. It did no harm to fetus or newborn and be recommended as a part of combined treatment for late gestoses.
Volkov
A E
AE
Kuzam
L N
LN
Borsheva
A A
AA
D001034:Apgar Score; D005260:Female; D005323:Fetal Monitoring; D005333:Fetus / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid
Vliianie fenibuta na plod i novorozhdennogo pri terapii gestozov.