title: Behavior of 3,4-endiol form of 2,3-diketo-gulono-delta-lactone formed from dehydro-L-ascorbic acid in deoxygenated and neutral solution.
abstract: The formation of L-ascorbic acid (AsA) was observed when dehydro-L-ascorbic acid (DHA) was dissolved in neutral buffer solutions under N2 bubbling at room temperature. The reduction of DHA was done with the lactonized compound of 2,3-diketo-L-gulonic acid (DKG), that is, the 3,4-endiol form of 2,3-diketo-gulono-delta-lactone (3,4-End DKGL). 3,4-End DKGL was formed from DHA or DKG (yield about 10%) under N2 bubbling in neutral buffer solution (pH 7.2). This material was not stable in neutral or alkaline solutions. 3,4-End DKGL suppressed more strongly the linoleic acid (LA) peroxidation in the medium containing 20% EtOH and 10 mM LA than did AsA. This may suggest the possibility that 3,4-End DKGL reproduces AsA from DHA in physiological status.
authors.affiliation: Laboratory of Food Chemistry, College of Agriculture, University of Osaka Prefecture, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takagi
authors.forename: A
authors.initials: A
authors.lastname: Kawajiri
authors.forename: K
authors.initials: K
authors.lastname: Nakata
authors.forename: N
authors.initials: N
authors.lastname: Morita
mesh_terms: D015083:2,3-Diketogulonic Acid / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000031:analogs & derivatives; D002851:Chromatography, High Pressure Liquid; D003683:Dehydroascorbic Acid; D006863:Hydrogen-Ion Concentration; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D012996:Solutions; D013400:Sugar Acids / Q000378:metabolism*
chemical_list: D012996:Solutions; D013400:Sugar Acids; D015083:2,3-Diketogulonic Acid; D001205:Ascorbic Acid; D003683:Dehydroascorbic Acid