title: Gastrointestinal transit of technetium-99m-labeled cellulose fiber and indium-111-labeled plastic particles.
abstract: We introduce two new nondigestible solid markers for gastrointestinal transit measurements. One is technetium-99m-labeled cellulose fiber [99mTc]CF, the other is indium-111-labeled plastic particles [111In]PP of 2- to 3-mm diameter. In six healthy male volunteers gastric emptying and small intestinal transit of the two markers were obtained simultaneously. Large intestinal transit of [111In]PP was also obtained. Technetium-99m CF had acceptable stability properties in the proximal gastrointestinal segments. Indium-111 PP was almost completely stable in all segments. Mean gastric emptying time was 1.13 +/- 0.24 hr (mean +/- s.d.) for [99mTc]CF and 1.94 +/- 0.78 hr for [111In]PP. The difference was significant (p less than 0.05). Mean small intestinal transit time was 3.85 +/- 0.61 hr (mean +/- s.d.) for [99mTc]CF and 4.03 +/- 0.34 hr for [111In]PP. The difference was not significant (p less than 0.5). Mean large intestinal transit time of [111In]PP was 23 +/- 11 hr (mean +/- s.d.). We also suggest a simple deconvolution principle for the interpretation of the small intestinal and the large intestinal transit data.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Copenhagen, Denmark.
authors.forename: J L
authors.initials: JL
authors.lastname: Madsen
authors.forename: M
authors.initials: M
authors.lastname: Jensen
mesh_terms: D000328:Adult; D002482:Cellulose; D005746:Gastric Emptying; D005772:Gastrointestinal Transit; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008863:Microspheres; D011137:Polystyrenes; D013667:Technetium
chemical_list: D007205:Indium Radioisotopes; D011137:Polystyrenes; D013667:Technetium; D002482:Cellulose