title: [Rifampicin pharmacokinetics in patients with pulmonary tuberculosis with concomitant helminthiasis].
abstract: Blood kinetics of rifampicin (rifadin) was studied in 57 patients with pulmonary tuberculosis. In 30 of them concomitant helminthiasis was diagnosed. It was shown that in the patients with helmintic invasion the blood levels of rifampicin were much lower (p less than 0.01). This was probably due to disorders in the hepatobiliar system detected with ultrasonic examinations and radioisotope hepatography.
authors.forename: V N
authors.initials: VN
authors.lastname: Korablev
authors.forename: R I
authors.initials: RI
authors.lastname: Pogodaeva
authors.forename: Z M
authors.initials: ZM
authors.lastname: Avtukhova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001711:Biotransformation; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008875:Middle Aged; D012293:Rifampin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D014201:Trematode Infections / Q000150:complications / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D012293:Rifampin
vernacular_title: Farmakokinetika rifampitsina u bol'nykh tuberkulezom legkikh s soputstvuiushcheĭ glistnoĭ invazieĭ.