title: Works in progress #4. Current status of local antibiotic delivery via an implantable pump.
abstract: We present our technique and results in using an implantable drug pump to deliver antibiotics locally in the treatment of two specific orthopaedic infections: chronic recalcitrant osteomyelitis and acutely infected total joints. This method of antibiotic delivery in conjunction with appropriate surgical management results in prolonged suppression of infection in 71% of patients with chronic recalcitrant osteomyelitis. In acutely infected arthroplasties we were able to salvage the prosthesis and suppress the infection in 18 of 20 cases.
authors.affiliation: Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: C R
authors.initials: CR
authors.lastname: Perry
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007592:Joint Diseases / Q000188:drug therapy; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy; D011183:Postoperative Complications / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local