Evidence for the presence of red and white cells within "platelet" aggregates formed in whole-blood.
Collagen-induced platelet aggregation and secretion (ATP-release) in whole-blood and platelet-rich plasma was compared. Although the amount of ATP released was comparable in whole-blood and platelet-rich plasma, the maximum extent of aggregation was greater when platelets were studied in their natural milieu, i.e. whole-blood. A scanning electron microscopic survey of the "platelet" aggregate formed in whole-blood showed that it contained erythrocytes and leucocytes as well as aggregated platelets.
Joseph
R
R
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202.
Welch
K M
KM
D'Andrea
G
G
Riddle
J M
JM
D000255:Adenosine Triphosphate / Q000378:metabolism; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002449:Cell Aggregation; D003094:Collagen / Q000494:pharmacology; D004912:Erythrocytes / Q000166:cytology; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000166:cytology; D008855:Microscopy, Electron, Scanning; D010974:Platelet Aggregation / Q000187:drug effects
D000255:Adenosine Triphosphate; D003094:Collagen