Salivary passage of 5-fluorouracil during continuous infusion.
Plasmatic and salivary concentrations of 5-FU were investigated in ten patients given 5-day continuous infusions of 5-fluorouracil (5-FU) (1 g/m2/day). Measurable concentrations of salivary 5-FU were scattered ranging from 6 to 100 ng/ml. Between individual 5-FU concentrations in saliva and plasma the coefficient of correlation was low. The theoretically predicted ratios of 5-FU concentrations in saliva over those in plasma, calculated as a function of salivary pH, did not correlate with the observed ratios, the majority of which ranged between 0.1 and 0.5. Noteworthy, 8 of 10 patients exhibited a more or less pronounced increase in 5-FU salivary excretion during 5-day continuous i.v. infusions.
Milano
G
G
Centre Antoine Lacassagne, Nice, France.
Thyss
A
A
Santini
J
J
Frenay
M
M
Francois
E
E
Schneider
M
M
Demard
F
F
D000368:Aged; D002851:Chromatography, High Pressure Liquid; D005472:Fluorouracil / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D012463:Saliva / Q000032:analysis / Q000378:metabolism*; D013997:Time Factors
D005472:Fluorouracil