Severe microvascular disease in type II diabetes of early onset. A family study.
Both early onset and late onset type II diabetes were present in one family of nine siblings. The three early onset type II diabetic siblings showed severe microvascular complications: proliferative retinopathy, diabetic nephropathy, and peripheral neuropathy. Early onset type II diabetes was not associated with any particular HLA haplotype. Early onset type II diabetes could be considered a clinical and genetic disease entity different from MODY type diabetes.
Scalvini
T
T
Cattedra di Patologia Medica, Università di Brescia, II Divisione di Medicina, Spedali di Brescia, Italy.
Spandrio
S
S
di Stefano
O
O
Cotelli
M C
MC
Carella
G
G
Balestrieri
G P
GP
D000328:Adult; D002096:C-Peptide / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D003925:Diabetic Angiopathies / Q000097:blood / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D002096:C-Peptide