title: [An experimental study on the biliary excretion of ceftizoxime in the presence and after relief of biliary obstruction with special reference to the influence of bile acid metabolism on the biliary excretion of the antibiotic].
abstract: The biliary excretion of ceftizoxime (CZX) in the presence and after relief of biliary obstruction was experimentally investigated in twelve dogs. In the presence of biliary obstruction, the biliary excretion of CZX was impaired and, immediately after relief of biliary obstruction, the existence of reverse shunt from the vascular system to the biliary tract was suggested. After relief of biliary obstruction, the biliary excretion of CZX and the ratio of [lithocholic acid + deoxycholic acid]/[cholic acid + chenodeoxycholic acid] in the bile were impaired in one group with external drainage as compared to the other group with internal drainage. It was experimentally proved that the biliary excretion of antibiotics seemingly related very closely to the bile acid metabolism and that it was increased by administration of the bile acid after external drainage or by normalization of the enterohepatic circulation of the bile acid after internal drainage.
authors.forename: H
authors.initials: H
authors.lastname: Kawaguchi
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism*; D015296:Ceftizoxime / Q000378:metabolism*; D002779:Cholestasis / Q000378:metabolism* / Q000601:surgery; D004285:Dogs; D004322:Drainage
chemical_list: D001647:Bile Acids and Salts; D015296:Ceftizoxime