title: A comparative study of peripheral to central circulation delivery times between intraosseous and intravenous injection using a radionuclide technique in normovolemic and hypovolemic canines.
abstract: Intraosseous infusion is considered a useful technique for administration of medications and fluids in emergency situations when peripheral intravascular access is unobtainable. This study examined the effectiveness of intraosseous infusion for delivery of substances to the central circulation. Central deliveries of a radionuclide tracer administered by the intraosseous and intravenous routes were evaluated during normovolemic and hypovolemic states. Intraosseous infusion achieved peripheral to central circulation transit times comparable to those achieved by the intravenous route. Analysis of variance revealed no statistically significant differences between the peripheral to central delivery times comparing intraosseous and intravenous administration. The results demonstrate that intraosseous infusion is a rapid and effective method of delivery to the central circulation and is an alternative method for intravascular access. This study also suggests that a radionuclide tracer is useful for the evaluation of transit times following intraosseous injection.
authors.affiliation: Department of Emergency Medicine, Akron City Hospital, Ohio 44309.
authors.forename: J L
authors.initials: JL
authors.lastname: Cameron
authors.forename: P B
authors.initials: PB
authors.lastname: Fontanarosa
authors.forename: A M
authors.initials: AM
authors.lastname: Passalaqua
mesh_terms: D000818:Animals; D001810:Blood Volume; D001842:Bone and Bones; D004285:Dogs; D004358:Drug Therapy / Q000379:methods; D005440:Fluid Therapy / Q000379:methods; D007262:Infusions, Intravenous / Q000379:methods*; D007263:Infusions, Parenteral / Q000379:methods*; D010599:Pharmacokinetics; D010865:Pilot Projects; D011849:Radioactive Tracers; D011868:Radioisotopes
chemical_list: D011849:Radioactive Tracers; D011868:Radioisotopes