[Effect of fenofibrate on fibrinogen concentration and blood viscosity. Consequences for myocardial microcirculation in coronary heart disease?].
The effect of fenofibrate (a clofibrate derivative) on fibrinogen concentration, blood viscosity and myocardial microcirculation was examined in 35 patients with coronary heart disease (n = 27) or hypertension (n = 8). After eight weeks' administration of 250 mg fenofibrate daily cholesterol and triglycerides levels decreased significantly, as did the fibrinogen concentration, from a mean of 300.7 +/- 75.1 mg/dl to 252.3 +/- 61.2 mg/dl (P less than 0.01). Plasma viscosity and erythrocyte aggregation were also significantly lowered (from 1.43 +/- 0.09 to 1.37 +/- 0.07 mPas and 15.0 +/- 3.1 to 13.5 +/- 2.2, respectively; P less than 0.01). In eight of twelve subjects selected from the whole group thallium myocardial scintigraphy demonstrated, after eight weeks of treatment with fenofibrate, a global (in two) or regional (in six) increase in blood flow. Reduction of fibrinogen concentration may in coronary heart disease achieve an improvement in myocardial microcirculation with decreased myocardial ischaemia.
Leschke
M
M
Abteilung für Kardiologie, Angiologie und Pneumologie, Universität Düsseldorf.
Höffken
H
H
Schmidtsdorff
A
A
Blanke
H
H
Egbring
R
R
Joseph
K
K
Strauer
B E
BE
D001809:Blood Viscosity / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004341:Drug Evaluation; D004903:Erythrocyte Aggregation / Q000187:drug effects; D005080:Exercise Test; D011345:Fenofibrate / Q000627:therapeutic use*; D005340:Fibrinogen / Q000032:analysis*; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008055:Lipids / Q000097:blood; D008833:Microcirculation / Q000187:drug effects; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D011422:Propionates / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes
D008055:Lipids; D011422:Propionates; D013794:Thallium Radioisotopes; D005340:Fibrinogen; D011345:Fenofibrate
Einfluss von Fenofibrat auf Fibrinogenkonzentration und Blutfluidität. Konsequenzen für die myokardiale Mikrozirkulation bei der koronaren Herzerkrankung?