Ultrastructure of parathyroid autografts in chronic renal failure including the occurrence of concentric membranous bodies and intermediate filaments.
The ultrastructure of long-term parathyroid autografts and their donor glands has been studied in nine patients with chronic renal failure. Autografts showed ultrastructural features of functional activity. Unusual findings included the presence of 'spironolactone-like' concentric membranous bodies derived from the endoplasmic reticulum in one hyperplastic autograft and prominent intracellular intermediate filaments (tonofilaments) in the donor parathyroid gland and recurrent autograft growths in another patient.
Ellis
H A
HA
Department of Pathology, University of Newcastle upon Tyne, UK.
Coaker
T
T
D000328:Adult; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007382:Intermediate Filaments / Q000648:ultrastructure; D007676:Kidney Failure, Chronic / Q000601:surgery*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010280:Parathyroid Glands / Q000637:transplantation* / Q000648:ultrastructure