title: Evaluation of the genetic effects of 238Pu incorporated into mice.
abstract: The genetic effects of 238Pu incorporated into male mice were estimated by several tests. The activity of the administered 238Pu nitrate varied from 7 to 1850 Bq/g of body weight. The average alpha-radiation dose absorbed in the testes ranged from 2 to 96 cGy, with a dose rate of 0.004-1 cGy/day. alpha-Radiation from 238Pu was shown to induce dominant lethal mutations (DLM) and reciprocal translocation (RT), chromosomal fragmentation and formation of abnormal sperm heads (ASH). The effect does not depend on the average alpha-radiation dose absorbed in the testis. The relative genetic efficiency of alpha-radiation, as compared with that of chronic alpha-radiation for the indices under study, was about 10-20.
authors.affiliation: N.I. Vavilov Institute of General Genetics, U.S.S.R. Academy of Sciences, Moscow.
authors.forename: M D
authors.initials: MD
authors.lastname: Pomerantseva
authors.forename: L K
authors.initials: LK
authors.lastname: Ramaya
authors.forename: V A
authors.initials: VA
authors.lastname: Shevchenko
authors.forename: G A
authors.initials: GA
authors.lastname: Vilkina
authors.forename: A M
authors.initials: AM
authors.lastname: Lyaginskaya
mesh_terms: D000512:Alpha Particles; D000818:Animals; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005720:Gamma Rays; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009929:Organ Size / Q000528:radiation effects; D011005:Plutonium / Q000633:toxicity*; D011247:Pregnancy; D013091:Spermatogenesis / Q000528:radiation effects*; D013737:Testis / Q000033:anatomy & histology / Q000528:radiation effects; D014178:Translocation, Genetic / Q000528:radiation effects
chemical_list: D011005:Plutonium