Effects of a low dose of naltrexone on glucose-induced allesthesia and hunger in humans.
In order to study the effects of a low dose of the opioid antagonist naltrexone on ingestive behavior for sucrose in humans, preference for sucrose solutions and feelings of hunger were scored on visual analogical scale by 14 healthy subjects with or without naltrexone. Effects of intragastric glucose load or water, and naltrexone (25 mg) or placebo were tested. At this low dose, naltrexone alone had a slight effect on allesthesia, and it produced a strong potentiation of glucose-induced allesthesia.
Melchior
J C
JC
Human Nutrition, INSERM U.286, Medical School X. Bichat, Paris, France.
Fantino
M
M
Rozen
R
R
Igoin
L
L
Rigaud
D
D
Apfelbaum
M
M
D000328:Adult; D004357:Drug Synergism; D004435:Eating / Q000187:drug effects*; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D006815:Hunger / Q000187:drug effects*; D008297:Male; D009271:Naltrexone / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D009271:Naltrexone; D005947:Glucose