[Effect of thermotherapy on human esophageal carcinoma in culture and clinical cases].
Multidisciplinary treatment for advanced esophageal carcinoma, which is not resectable in many cases, has become an important subject to study. We have reported the effectiveness of thermotherapy in treatment of esophageal carcinoma by basic experiments using three cell strains of human esophageal carcinoma designated as SGF-3,4,5. Based on the results of the basic experiments, we have performed thermotherapy combined with radiotherapy, chemotherapy and immunotherapy on cases of advanced esophageal carcinoma since October 1985. As for the basic experiment, proliferation of SGF-3 was inhibited at more than 40 degrees C, SGF-4 at more than 41 degrees C and SGF-5 at more than 42 degrees C. We did not observe the recovery of the growth of SGF-3 after heating at 41 degrees C for 72 hours and 42 degrees C for more than 24 hours. And the growth of SGF-4 after heating at 42 degrees C for more than 48 hours did not recover either. No recovery of the growth of SGF-5 after heating at 42 degrees C for 72 hours was noted. Based on the data, combined therapy was performed in 12 patients with advanced esophageal carcinoma. The evaluation of the local response to the combined thermotherapy revealed CR in five cases, PR in five and NC in two.
Shinbo
T
T
2nd. Dept. of Surgery, Toyama Medical and Pharmaceutical University.
Katoh
H
H
Saitoh
M
M
Saitoh
T
T
Shimizu
T
T
Otagri
H
H
Tazawa
K
K
Fujimaki
M
M
D000368:Aged; D000369:Aged, 80 and over; D002455:Cell Division; D002460:Cell Line; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D005260:Female; D006358:Hot Temperature; D006801:Humans; D006979:Hyperthermia, Induced; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D010844:Picibanil / Q000627:therapeutic use
D010844:Picibanil; D002945:Cisplatin