Determination of thermodynamic parameters of complexation using a nonlinear regression method.
The new model and method introduced here allow the determination of more than one unknown from one set of raw experimental data. Even though the method was used to treat data from the complexation of phenytoin with cyclodextrins, the same approach could be exploited for other drug interaction systems. The method allows for a meaningful comparison of thermodynamic parameters for the interaction of either one drug with different cyclodextrins or one cyclodextrin with different drugs. The use of the approach could enhance the ability of the pharmaceutical scientist to analyze data from the solubility method to propose a rationale of interaction between drugs and complexing agents.
Menard
F A
FA
Dedhiya
M G
MG
Rhodes
C T
CT
D002626:Chemistry, Pharmaceutical; D008956:Models, Chemical; D010672:Phenytoin / Q000032:analysis; D012044:Regression Analysis; D013816:Thermodynamics
D010672:Phenytoin