[Features of ischemic injuries to membranes and activation of lipid peroxidation in the myocardium of rats of various ages].
The model of interrupted ischemia of the isolated heart has been used to show that the yield of lactate dehydrogenase into perfusate in experiments on old rats is described by more sharply pronounced S-like dependence than that in young immature animals. The activation of lipid peroxidation precedes the sarcolemma damage and is relatively more manifested in rats of middle and old age. The respiratory control of mitochondria (in homogenates) decreases considerably already 20 min after ischemia, however mitochondria retain their ability to synthesize ATP 3 h later as well. The causal-effect relationship between the activation of lipid peroxidation and partial disturbance of the mitochondrial function remains unclear.
Lemeshko
V V
VV
Nikitchenko
Iu V
IuV
Troianova
V N
VN
Malanda
P
P
Belostotskaia
L I
LI
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000375:Aging / Q000378:metabolism*; D000818:Animals; D003327:Coronary Disease / Q000201:enzymology / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D015227:Lipid Peroxidation; D049449:Luminescence; D008315:Malondialdehyde / Q000378:metabolism; D008929:Mitochondria, Heart / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration
D008315:Malondialdehyde; D000255:Adenosine Triphosphate; D007770:L-Lactate Dehydrogenase
Osobennosti ishemicheskogo povrazhdeniia membran i aktivatsiia perekisnogo okisleniia lipidov v miokarde krys raznogo vozrasta.