Relationship between rotational behaviour induced by apomorphine and caffeine in rats with unilateral lesion of the nigrostriatal pathway.
The contralateral rotational behaviour produced by apomorphine and caffeine has been studied in 100 rats with unilateral lesion of the nigrostriatal pathway induced with 6-OHDA. Rats with a two-peak rotational pattern induced by apomorphine, showed a greater number of contralateral turns, induced by apomorphine and caffeine, than rats which did not show this rotational pattern. A correlation was observed between the number of rotations induced by apomorphine and those induced by caffeine. A relationship between the two-peak rotational pattern induced by apomorphine and the initial-peak pattern induced by caffeine was also observed.
Casas
M
M
Laboratori de Neuropsicofarmacología i Programa Sant Pau-CITRAN, Fundació d'Investigació de la Santa Creu i Sant Pau, Hospital de Sant Pau (Medical School, U.A.B.), Barcelona, Spain.
Ferré
S
S
Cobos
A
A
Grau
J M
JM
Jané
F
F
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000502:physiology*; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra / Q000502:physiology*
D002110:Caffeine; D001058:Apomorphine