[The role of the dopamine and noradrenaline systems in regulating autogenic motor activity in rat pups].
In experiments on 3-day rat puppies, studies have been made of the effect of a stimulator of noradrenaline receptors--clonidine, and a stimulator of dopamine receptors--apomorphine on autogenic motor activity. It was shown that clonidine injections result in a significant increase of this activity, whereas apomorphine slightly decreases the latter. The data obtained in the present work together with those described earlier for l-DOPA effects, suggest that double regulation of autogenic activity is realized at early stages of ontogenesis. This regulation includes excitatory noradrenergic mechanisms and inhibitory influences which are mediated presumably by dopaminergic systems of the brain.
Timofeeva
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D000818:Animals; D000831:Animals, Newborn; D001058:Apomorphine / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D007980:Levodopa / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology
D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D007980:Levodopa; D003000:Clonidine; D001058:Apomorphine; D004298:Dopamine; D009638:Norepinephrine
O roli dofaminovoĭ i noradrenalinovoĭ sistem v reguliatsii autogennoĭ motornoĭ aktivnosti krysiat.