title: [Determination of dextromethorphan and its major metabolite dextrorphan by gas chromatography].
abstract: A gas chromatography assay has been developed for the determination of dextromethorphan and dextrorphan in human fluids. Drugs are extracted with chloroform-isopropanol-n-heptane (50/17/33, v/v) form alkalinized samples using cyclizine as an internal standard, analysed using a 3 p. cent OV-17 column, and detected by selective nitrogen detection. The lower detection limits are 0.4 and 0.7 micrograms/l for dextromethorphan and dextrorphan, respectively.
authors.affiliation: Institut de Médecine Légale, Strasbourg.
authors.forename: P
authors.initials: P
authors.lastname: Kintz
authors.forename: P
authors.initials: P
authors.lastname: Mangin
authors.forename: A
authors.initials: A
authors.lastname: Lugnier
authors.forename: A J
authors.initials: AJ
authors.lastname: Chaumont
mesh_terms: D002849:Chromatography, Gas / Q000379:methods; D003501:Cyclizine / Q000097:blood*; D003915:Dextromethorphan / Q000097:blood*; D003917:Dextrorphan / Q000097:blood*; D007981:Levorphanol / Q000031:analogs & derivatives*; D009019:Morphinans / Q000097:blood*; D012015:Reference Standards; D015203:Reproducibility of Results
chemical_list: D009019:Morphinans; D003917:Dextrorphan; D007981:Levorphanol; D003915:Dextromethorphan; D003501:Cyclizine
vernacular_title: Dosage du dextromethorphane et de son métabolite principal le dextrorphane par chromatographie gazeuse.