title: Brain sulfide levels in anaesthesia: a comparison with hydrogen sulfide intoxication.
abstract: Although sublethal concentrations of hydrogen sulfide produce a state not unlike anaesthesia, measurement of rat brain sulfide levels by gas dialysis and IC with electrochemical detection after either 1.5 g/kg urethane or 42 mg/kg pentobarbital failed to demonstrate any changes as compared with endogenous brain sulfide levels of saline-injected controls. This suggests that the mechanisms underlying anaesthesia are not directly linked to endogenous cerebral sulfide levels.
authors.affiliation: Department of Pharmacology, University of Alberta, Edmonton, Canada.
authors.forename: M W
authors.initials: MW
authors.lastname: Warenycia
authors.forename: R J
authors.initials: RJ
authors.lastname: Reiffenstein
authors.forename: L R
authors.initials: LR
authors.lastname: Goodwin
authors.forename: F P
authors.initials: FP
authors.lastname: Dieken
mesh_terms: D000758:Anesthesia; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D006862:Hydrogen Sulfide / Q000506:poisoning*; D008297:Male; D010424:Pentobarbital; D051381:Rats; D011919:Rats, Inbred Strains; D013440:Sulfides / Q000032:analysis*; D014520:Urethane
chemical_list: D013440:Sulfides; D014520:Urethane; D010424:Pentobarbital; D006862:Hydrogen Sulfide