Experimental renal papillary necrosis in the Syrian hamster.
These studies evaluate the susceptibility of the Syrian hamster to the induction of renal papillary lesions after exposure to 2-bromethylamine (2-BEA), mefenamic acid, indomethacin, acetaminophen and phenylbutazone. In most cases there were 25 animals per dose group. Papillary necrosis was produced by single or multiple ip doses of 75 mg 2-BEA/kg and above, and was present within 12 hr of administration of a dose of 500 mg/kg body weight. There were lesions in the renal papilla of hamsters 10 days after a single dose of 500 mg 2-BEA/kg. The severity of papillary lesions increased up to 4 days after exposure in hamsters given a single dose of either 250 or 500 mg 2-BEA/kg. The severity of papillary lesions did not increase with the number of doses in hamsters given multiple doses (2-5) of 100 mg 2-BEA/kg. Renal papillary necrosis was observed in about 40% of hamsters given 100, 200 or 400 mg mefenamic acid/kg. Only a few of the hamsters given indomethacin had renal papillary lesions and none of those given acetaminophen (up to 400 mg/kg) or phenylbutazone (up to 600 mg/kg) developed renal papillary lesions.
Carlton
W W
WW
Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
Engelhardt
J A
JA
D000082:Acetaminophen / Q000633:toxicity; D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D005021:Ethylamines / Q000633:toxicity; D007213:Indomethacin / Q000633:toxicity; D007679:Kidney Medulla / Q000187:drug effects* / Q000473:pathology; D007681:Kidney Papillary Necrosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008528:Mefenamic Acid / Q000633:toxicity; D008647:Mesocricetus; D010653:Phenylbutazone / Q000633:toxicity
D005021:Ethylamines; C004504:2-bromoethylamine; D000082:Acetaminophen; D008528:Mefenamic Acid; D010653:Phenylbutazone; D007213:Indomethacin