Lipid cell tumor of the ovary: steroid hormone secretory pattern and localization using 75Se-selenomethylcholesterol.
Ovarian lipid cell tumors are rare and can be difficult to localize by conventional means. We report a postmenopausal patient where rapid progression of symptoms and very high sebum levels suggested the presence of such a tumor which could not be visualized by computed tomography or ultrasound. Localization was accomplished noninvasively using 75Se-selenomethylcholesterol. Peripheral and ovarian vein steroid concentrations suggest that the tumor produced androgens preferentially by way of the delta 4 steroidogenesis pathway.
Younis
J S
JS
Department of Obstetrics and Gynecology, Hadassah University Hospital, Jerusalem, Israel.
Bercovici
B
B
Zlotogorski
A
A
Horne
T
T
Glaser
B
B
D000314:Adrenal Rest Tumor / Q000000981:diagnostic imaging* / Q000378:metabolism; D000368:Aged; D002784:Cholesterol / Q000031:analogs & derivatives*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006801:Humans; D016566:Organoselenium Compounds; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D011877:Radionuclide Imaging; D012644:Selenium Radioisotopes
D012739:Gonadal Steroid Hormones; D016566:Organoselenium Compounds; D012644:Selenium Radioisotopes; C045082:6-selenomethylcholesterol; D002784:Cholesterol