Age differences in the body temperature response to restraint-cold stress.
Female Fischer 344 rats, 3, 11, and 24-months old were subjected to 3 hr of restraint-cold stress once each week for 4 weeks. Body (colon) temperature was recorded every 10 min during restraint and during postrestraint recovery until temperature returned to the prerestraint level. Thermoregulatory adaptation during consecutive restraint sessions was noted in 3- and 11-month-old rats but not in 24-month-old rats. Significant temperature recovery was accomplished after the second restraint session for 3- and 11-month-old rats, but this was not accomplished in the older 24-month rats until after four restraint sessions. The role of hypothermia in restraint-induced ulceration is questioned, especially as it pertains to elderly rats.
Paré
W P
WP
Veterans Administration Medical Center, Perry Point, MD 21902.
D000375:Aging / Q000502:physiology*; D000818:Animals; D001143:Arousal / Q000502:physiology*; D001833:Body Temperature Regulation; D003080:Cold Temperature; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012149:Restraint, Physical / Q000523:psychology; D013276:Stomach Ulcer / Q000523:psychology