title: Natural resistance in mice against Friend cells injected intravenously. III. Comparison between in vivo and in vitro passaged interferon-sensitive (745) and interferon-resistant (3Cl8) cell clones.
abstract: In vitro (FLC-Vt) or in vivo (FLC-V) passaged Friend erythroleukaemia cells of DBA/2 origin were tested for susceptibility to natural resistance (NR) in vivo or to NK cell activity in vitro. Scarcely oncogenic FLC-Vt cells were highly susceptible to in vivo NR (measured as rapid organ clearance or growth inhibition in lethally irradiated mice) or to in vitro NK attack. Conversely, highly oncogenic FLC-V cells were weakly susceptible to NR and to NK as well. These data seem to point out that natural immunity, which is up-regulated by endogenous or exogenous interferons, can play a significant role in surveillance against mouse leukaemic cells of retrovirus origin.
authors.affiliation: Department of Hygiene, University of Perugia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Neri
authors.forename: T
authors.initials: T
authors.lastname: Zei
authors.forename: E
authors.initials: E
authors.lastname: Bonmassar
authors.forename: G B
authors.initials: GB
authors.lastname: Rossi
authors.forename: G
authors.initials: G
authors.lastname: Fiorucci
authors.forename: A N
authors.initials: AN
authors.lastname: Iorio
mesh_terms: D000818:Animals; D002351:Carrageenan / Q000494:pharmacology; D002460:Cell Line; D002999:Clone Cells; D003520:Cyclophosphamide / Q000494:pharmacology; D003601:Cytotoxicity Tests, Immunologic; D005622:Friend murine leukemia virus; D007113:Immunity, Innate / Q000187:drug effects; D007275:Injections, Intravenous; D007370:Interferon Type I / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology*; D051379:Mice; D008811:Mice, Inbred DBA; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000276:immunology
chemical_list: D007370:Interferon Type I; D003520:Cyclophosphamide; D002351:Carrageenan