title: Salivary passage of 5-fluorouracil during continuous infusion.
abstract: Plasmatic and salivary concentrations of 5-FU were investigated in ten patients given 5-day continuous infusions of 5-fluorouracil (5-FU) (1 g/m2/day). Measurable concentrations of salivary 5-FU were scattered ranging from 6 to 100 ng/ml. Between individual 5-FU concentrations in saliva and plasma the coefficient of correlation was low. The theoretically predicted ratios of 5-FU concentrations in saliva over those in plasma, calculated as a function of salivary pH, did not correlate with the observed ratios, the majority of which ranged between 0.1 and 0.5. Noteworthy, 8 of 10 patients exhibited a more or less pronounced increase in 5-FU salivary excretion during 5-day continuous i.v. infusions.
authors.affiliation: Centre Antoine Lacassagne, Nice, France.
authors.forename: G
authors.initials: G
authors.lastname: Milano
authors.forename: A
authors.initials: A
authors.lastname: Thyss
authors.forename: J
authors.initials: J
authors.lastname: Santini
authors.forename: M
authors.initials: M
authors.lastname: Frenay
authors.forename: E
authors.initials: E
authors.lastname: Francois
authors.forename: M
authors.initials: M
authors.lastname: Schneider
authors.forename: F
authors.initials: F
authors.lastname: Demard
mesh_terms: D000368:Aged; D002851:Chromatography, High Pressure Liquid; D005472:Fluorouracil / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D012463:Saliva / Q000032:analysis / Q000378:metabolism*; D013997:Time Factors
chemical_list: D005472:Fluorouracil