[Corticosteroids and cerebral vessel permeability during embryonic development].
The effects of cortisol on the development of the blood-brain barrier (b.b.b.) were microscopically investigated in the chick embryo optic tectum using horseradish peroxidase (hrp) as marker of vascular permeability. Hrp was injected intracardially at the 15th and 21st incubation day (i.d.), i.e. 5 and 11 days after the last administration of the drug (10 micrograms/50 microliters saline solution at the 8th and 10th i.d.). This treatment caused damage to the maturation process of the b.b.b. to hrp. The intraneural blood vessel walls were not able to prevent the marker extravasation which was massive at the 15th i.d. and circumscribed to limited perivascular areas at the 21st i.d. A possible pathogenetic mechanism of this phenomenon is discussed.
Ribatti
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D
Virgintino
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D
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002199:Capillary Permeability / Q000187:drug effects*; D002642:Chick Embryo; D006854:Hydrocortisone / Q000493:pharmacokinetics / Q000494:pharmacology*; D013477:Superior Colliculi / Q000196:embryology*
D006854:Hydrocortisone
I corticosteroidi e la permeabilità dei vasi cerebrali durante lo sviluppo embrionale.