Effects of fish oil on gastric mucosal 6-keto-PGF1 alpha synthesis and ethanol-induced injury.
Fundic mucosal content and synthesis of 6-ketoprostaglandin F1 alpha, the major prostanoid in the rat gastric mucosa, were determined after rats had ingested a diet containing 10% fish oil or 10% corn oil for 4 wk. 6-Ketoprostaglandin F1 alpha content and synthesis in rats fed a fish oil-supplemented diet were reduced significantly compared with rats receiving a corn oil-supplemented diet (P less than 0.05). However, rats receiving 10% fish oil for 8 wk sustained significantly less gastric mucosal injury after intragastric challenge with 15% and then with absolute ethanol than rats receiving 10% corn oil or regular chow for 8 wk (P less than 0.05). Thus fish oil ingestion protected the gastric mucosa even though fish oils reduced mucosal prostaglandin synthesis.
Faust
T
T
Department of Internal Medicine, Veterans Administration Medical Center, Dallas, Texas.
Redfern
J S
JS
Lee
E
E
Feldman
M
M
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis*; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000517:prevention & control; D015430:Weight Gain / Q000187:drug effects
D005395:Fish Oils; D000431:Ethanol; D015121:6-Ketoprostaglandin F1 alpha; D007213:Indomethacin