title: Infection of human T-cell leukemia virus type I and development of human T-cell leukemia lymphoma in patients with hematologic neoplasms: a possible linkage to blood transfusion.
abstract: Among 354 adult patients with either hematological malignancy or aplastic anemia, eight were positive for anti-HTLV-I antibodies; six of eight had received multiple transfusions. There was an approximately 3.5-fold increase (P less than .001) of HTLV-I seropositivity in the patients with hematologic disease (8 of 354, 2.23%) compared to the healthy adults older than 20 years (34 of 5252, .65%). Two hematological patients, one with Hodgkin's disease and one with acute promyelocytic leukemia, were found to be positive for HTLV-I, and developed and died of adult T-cell leukemia/lymphoma (ATL) subsequently. Both were long-term survivors of the primary disease and had received multiple transfusions. The latent period from blood transfusion to onset of ATL was 6 months and 11 years, respectively. Immunocompromised patients, who were seropositive for HTLV-I, may be at increased risk for ATL compared to healthy carriers of HTLV-I, and the latent period may be shorter.
authors.affiliation: Department of Laboratory Medicine, National Taiwan University Medical School, Taipei, Republic of China.
authors.forename: Y C
authors.initials: YC
authors.lastname: Chen
authors.forename: C H
authors.initials: CH
authors.lastname: Wang
authors.forename: I J
authors.initials: IJ
authors.lastname: Su
authors.forename: C Y
authors.initials: CY
authors.lastname: Hu
authors.forename: M J
authors.initials: MJ
authors.lastname: Chou
authors.forename: T H
authors.initials: TH
authors.lastname: Lee
authors.forename: D T
authors.initials: DT
authors.lastname: Lin
authors.forename: T Y
authors.initials: TY
authors.lastname: Chung
authors.forename: C H
authors.initials: CH
authors.lastname: Liu
authors.forename: C S
authors.initials: CS
authors.lastname: Yang
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D001803:Blood Transfusion; D015139:Blotting, Southern; D004273:DNA, Neoplasm / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000150:complications* / Q000628:therapy; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000382:microbiology*; D008223:Lymphoma / Q000150:complications* / Q000628:therapy; D008297:Male; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D004273:DNA, Neoplasm; D004279:DNA, Viral