title: Effects of allyl sulfide, germanium and NaCl on the development of glutathion S-transferase P-positive rat hepatic foci initiated by diethylnitrosamine.
abstract: The modification potentials of allyl sulfide, germanium and NaCl on the development of preneoplastic hepatic enzyme altered foci were examined in an in vivo mid-term assay system. Rats were initially given a single dose (200 mg/kg), intraperitoneal injection of diethylnitrosamine (DEN) and, starting 2 weeks later, were treated with allyl sulfide, germanium and NaCl at a concentration of 0.5%, 0.05% and 5%, respectively, in the diet for 6 weeks and then killed. All rats were subjected to two-thirds partial hepatectomy at week 3. The modifying potential was scored by comparing the number and area per cm2 of induced glutathione S-transferase placental form-positive (GST-P+) foci in the liver with those of the corresponding control group given DEN alone. Allyl sulfide exerted an obvious inhibition of the development of GST-P+ foci as regards both number and area. On the contrary, germanium showed a significant increase in the number of GST-P+ foci, although the data for area were not altered. NaCl had no modifying effect on their development.
authors.affiliation: Department of Anatomical Pathology, Korea Cancer Center Hospital, Seoul.
authors.forename: J J
authors.initials: JJ
authors.lastname: Jang
authors.forename: K J
authors.initials: KJ
authors.lastname: Cho
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000498:Allyl Compounds; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003043:Cocarcinogenesis; D004052:Diethylnitrosamine; D005857:Germanium / Q000494:pharmacology*; D005982:Glutathione Transferase / Q000378:metabolism; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000201:enzymology; D008297:Male; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000201:enzymology; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology*; D013440:Sulfides / Q000494:pharmacology*
chemical_list: D000498:Allyl Compounds; D013440:Sulfides; D005857:Germanium; D004052:Diethylnitrosamine; D012965:Sodium Chloride; C038491:allyl sulfide; D005982:Glutathione Transferase