[Evaluation of the immediate effect of ligustrazine in chronic cor pulmonale].
Twenty patients with chronic cor pulmonale were studied to assess the immediate effect of Ligustrazini on hemodynamic and right cardiac function. After intravenous administration of Ligustrazini at rest, there was statistically significant decrease in pulmonary arterial pressure, pulmonary vascular resistance and heart rate, increase in cardiac output and improvement in right cardiac function. Maximal effect was observed half an hour after treatment. But the effect disappeared after discontinuing the treatment of Ligustrazini for one hour. It is suggested that the effect of Ligustrazini appears early but does not last long.
Peng
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D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010992:Plethysmography, Impedance; D011660:Pulmonary Heart Disease / Q000188:drug therapy*; D011719:Pyrazines / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D011719:Pyrazines; D014665:Vasodilator Agents; C017953:tetramethylpyrazine