A radiosynthesis of fluorine-18 fluoromisonidazole.
A new preparation of [18F]fluoromisonidazole [1H-1-(3-[18F] fluoro-2-hydroxypropyl)-2-nitroimidazole] is presented as a two-step, two-pot reaction sequence. The method is useful for the production of 20-30 mCi quantities of this compound from [18F]fluoride, available in 40% radiochemical yield at end of bombardment (EOB) with a specific activity (nca) of greater than 650 Ci/mmol (EOB) and a synthesis time of approximately 140 min. The key feature of the reaction scheme is the preparation of a new fluoroalkylating agent, [18F]epifluorohydrin.
Grierson
J R
JR
Department of Radiology, University of Washington, Seattle 98195.
Link
J M
JM
Mathis
C A
CA
Rasey
J S
JS
Krohn
K A
KA
D005462:Fluorine Radioisotopes; D007553:Isotope Labeling / Q000379:methods; D008920:Misonidazole / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D005462:Fluorine Radioisotopes; D008920:Misonidazole