title: c-Fos mRNA induction under vitamin B6 antagonist-induced seizure.
abstract: c-Fos mRNA expression was studied in mouse brain after vitamin B6 antagonist-induced seizure. The vitamin B6 antagonists used were hydrazine, thiosemicarbazide, penicillamine and deoxypyridoxine. Only deoxypyridoxine was effective in increasing c-fos mRNA and c-fos protein expression in nerve cells. The other 3 antagonists had levels of c-fos mRNA below or equal to basal level. The seizure activity induced by several vitamin B6 antagonists resulted in different effects on c-fos gene expression.
authors.affiliation: Department of Biochemistry, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Mizuno
authors.forename: T
authors.initials: T
authors.lastname: Mizobuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Ishibashi
authors.forename: M
authors.initials: M
authors.lastname: Matsuda
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D001921:Brain / Q000378:metabolism*; D006834:Hydrazines / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010396:Penicillamine / Q000494:pharmacology; D011519:Proto-Oncogenes; D011736:Pyridoxine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis*; D012640:Seizures / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism*; D012663:Semicarbazides / Q000494:pharmacology
chemical_list: D006834:Hydrazines; D012333:RNA, Messenger; D012663:Semicarbazides; C029424:hydrazine; C005151:thiosemicarbazide; D010396:Penicillamine; D011736:Pyridoxine