title: Aminophylline dosage in acute severe asthma.
abstract: In 27 cases of acute severe asthma, a loading dose of 5 mg/kg of aminophylline (omitted if already receiving oral theophylline) followed by a continuous infusion of 1 mg/kg per hour gave satisfactory theophylline levels at 4 h and 24 h. Theophylline clearance rates varied widely, vomiting was common, but unrelated to blood theophylline levels.
authors.affiliation: Department of Child Health, Kings's College Hospital Denmark Hill, London, United Kingdom.
authors.forename: J G
authors.initials: JG
authors.lastname: Gleeson
authors.forename: J F
authors.initials: JF
authors.lastname: Price
mesh_terms: D000628:Aminophylline / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D013806:Theophylline / Q000097:blood
chemical_list: D000628:Aminophylline; D013806:Theophylline