[Transformation of glycyrrhizic acid. Synthesis of glycopeptides of glycyrrhizic acid monomethyl ether, having anti-inflammatory and immunostimulating action].
Three triterpene glycopeptides, glycyrrhizic acid monomethly ester derivatives containing peptide fragment of N-acetylmuramoyldipeptide and its analogues, are synthesized. They possess high prednizolone-like antiinflammatory activity and display pronounced stimulative effect on humoral factors of immunity.
Tolstikov
G A
GA
Baltina
L A
LA
Kondratenko
R M
RM
Nasyrov
Kh M
KhM
Baschenko
N Zh
NZh
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis*; D000373:Agglutinins / Q000032:analysis; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D000917:Antibody Formation; D055598:Chemical Phenomena; D002621:Chemistry; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives*; D019695:Glycyrrhizic Acid / Q000031:analogs & derivatives; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D051381:Rats
D000276:Adjuvants, Immunologic; D000373:Agglutinins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006020:Glycopeptides; D019695:Glycyrrhizic Acid; C060174:glycyrrhizic acid methyl ester; D006034:Glycyrrhetinic Acid
Transformatsii glitsirrizinovoĭ kisloty. Sintez glikopeptidov monometilovogo éfira glitsirrizinovoĭ kisloty, proiavlliaiushchikh protivosvospatitel'noe i immunostimuliruiushchee deĭstvie.