title: Central ventilatory dysfunction in myelodysplasia: an independent determinant of survival.
abstract: Central ventilatory dysfunction (CVD) is a significant complication of myelodysplasia with Arnold-Chiari type II defect. The records of 616 patients with myelodysplasia were reviewed and CVD was documented in 35 cases (5.7 per cent): it was the single most common cause of death in this population. There was no significant association between CVD and level of lesion, severity of hydrocephalus, hemorrhage or infection. The effects of CVD may be variable, with some patients having spontaneous remission and others having severe, often fatal, disruption of ventilation.
authors.affiliation: Department of Rehabilitation Medicine and Pediatrics, University of Washington, School of Medicine, Seattle 98195.
authors.forename: R M
authors.initials: RM
authors.lastname: Hays
authors.forename: R A
authors.initials: RA
authors.lastname: Jordan
authors.forename: J F
authors.initials: JF
authors.lastname: McLaughlin
authors.forename: R E
authors.initials: RE
authors.lastname: Nickel
authors.forename: L D
authors.initials: LD
authors.lastname: Fisher
mesh_terms: D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D009436:Neural Tube Defects / Q000150:complications* / Q000401:mortality; D011379:Prognosis; D012120:Respiration Disorders / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D012189:Retrospective Studies