[Changes in thrombocyte-vascular hemostasis and cyclic nucleotide levels after anti-arrhythmia therapy in patients with ischemic heart disease].
Platelet-vascular hemostasis and cyclic nucleotide levels as well as the effects of mexitil, ritmilen and prolecofen on those were examined in 58 coronary patients with various heart rhythm disorders. The patients showed considerably increased platelet activity, low prostacyclin level and high thromboxane and cyclic nucleotides levels, particularly in patients with high-grade ventricular extrasystoles. Mexitil did not essentially affect the parameters in question. Ritmilen produced a significant increase in 6-keto-PGF1 alpha and a decrease of platelet activity. In prolecofen-treated patients, platelet activity decreased significantly, cAMP and cGMP dropped while the cAMP/cGMP ratio went up; prostacyclin and thromboxane changes were not significant. This may be a mechanism of prolecofen's antiarrhythmic action.
Liusov
V A
VA
Dudaev
V A
VA
Borodkin
V V
VV
Rudakov
A V
AV
D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D003327:Coronary Disease / Q000097:blood / Q000150:complications*; D004206:Disopyramide / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000627:therapeutic use*; D008875:Middle Aged; D009712:Nucleotides, Cyclic / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011405:Propafenone / Q000627:therapeutic use
D009712:Nucleotides, Cyclic; D010975:Platelet Aggregation Inhibitors; D008801:Mexiletine; D011405:Propafenone; D004206:Disopyramide
Izmeneniia trombotsitarno-sosudistogo gemostaza i soderzhaniia tsiklicheskikh nukleotidov pod vliianiem antiaritmicheskoĭ terapii u bo'lnykh ishemicheskoĭ bolez'niu serdtsa.