Elevated aluminum persists in serum and tissues of rabbits after a six-hour infusion.
The half-life of aluminum was estimated in selected tissues and fluids in a representative mammal, the rabbit. After a single iv aluminum infusion, half-lives were determined by serial killing of rabbits and aluminum quantitation in selected tissues and fluids by electrothermal atomic absorption spectroscopy. Tissues and fluids demonstrating a significant increase 4 hr after the 200 mumol/kg aluminum dose were the bile, kidney, liver, lung, serum, and spleen. Aluminum concentration did not significantly increase above control in the adrenal gland, bone, heart, muscle, testis, thyroid gland, or selected central nervous system regions. Biliary aluminum concentration returned to control within 12 hr after infusion. Estimated half-lives were 113 days in spleen, 74 days in liver, 44 days in lung, 42 days in serum, 4.2 days in kidney cortex, and 2.3 days in kidney medulla. The kidney also demonstrated another half-life greatly exceeding 100 days. The results demonstrate that aluminum persists in various tissues and fluids for different lengths of time. The calculated half-life of aluminum in these tissues is substantially longer than previously estimated half-lives based on serum aluminum determination. The persistence of aluminum in the liver and other tissues may serve as a source of continuous aluminum exposure for sensitive target organs such as the brain. These calculated half-lives establish the normal rate of aluminum elimination from tissues. Future studies could determine the influence of factors such as uremia or chelation therapy on the rate of aluminum elimination from storage sites as well as serum.
Yokel
R A
RA
College of Pharmacy, University of Kentucky, Lexington 40536-0082.
McNamara
P J
PJ
D000535:Aluminum / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D000818:Animals; D006207:Half-Life; D007262:Infusions, Intravenous; D008297:Male; D011817:Rabbits; D014018:Tissue Distribution
D000535:Aluminum