Hemodynamic effects of intravenous lecithin-based perfluorocarbon emulsions in dogs.
We evaluated and compared the acute hemodynamic effects of perfluorooctylbromide-100% (PFOB), a fluorocarbon emulsified in lecithin without pluronic-F68 (F68), to those of a standard iodinated contrast agent, renografin-76% (R76), and Fluosol-DA 20% (Fluosol), a fluorocarbon emulsified in part by F68. Five open chest dogs were instrumented to evaluate hemodynamic changes after iv injection of PFOB (1 ml.1 g/kg) and R76 (1 ml.0.37 g of iodine/kg). Fluosol (1 ml.0.2 g/kg) was given to two of the five dogs at the end of their study. Fluosol caused transient hemodynamic collapse in both dogs. R76 caused the known transient effect of hypotension (-15.4 +/- 3.3%) followed by hypertension (6.5 +/- 2.7%) and an increase in aortic flow (29.3 +/- 3.9% at 30 sec). PFOB caused minimal, clinically insignificant decrease in aortic flow (4 +/- 1% at 10 sec).
Mattrey
R F
RF
Department of Radiology, University of California, San Diego.
Hilpert
P L
PL
Long
C D
CD
Long
D M
DM
Mitten
R M
RM
Peterson
T
T
D000818:Animals; D004285:Dogs; D004655:Emulsions; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage / Q000633:toxicity*; D006439:Hemodynamics / Q000187:drug effects*; D006842:Hydrocarbons, Brominated; D007262:Infusions, Intravenous; D008297:Male; D010713:Phosphatidylcholines
D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D010713:Phosphatidylcholines; C003072:perflubron