title: [Treatment of patients with destructive pulmonary tuberculosis with chemotherapeutic preparations combined with sodium nucleinate].
abstract: The treatment efficacy was studied in 90 patients with destructive tuberculosis of the lungs. 50 of them were subjected to combined chemotherapy with inclusion of sodium nucleinate and 40 were treated with the tuberculostatics alone. It was shown that sodium nucleinate improved the host metabolism and in particular increased nucleonemia. As compared to the controls in the patients treated with sodium nucleinate there was a decrease in the periods of the host disintoxication, discontinuation of tubercle bacilli isolation and closing of destructive cavities. Sodium nucleinate was satisfactorily tolerated by the patients, it induced no adverse reactions and had a favourable effect on the patients immunity.
authors.forename: Zh Z
authors.initials: ZhZ
authors.lastname: Kharakter
authors.forename: A V
authors.initials: AV
authors.lastname: Pavlenko
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006801:Humans; D008875:Middle Aged; D009696:Nucleic Acids / Q000008:administration & dosage*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D009696:Nucleic Acids; C013683:sodium nucleinate
vernacular_title: Lechenie bol'nykh destruktivnym tuberkulezom legkikh khimiopreparatami v sochetanii s nukleinatom natriia.