Studies on gastric antiulcer active agents. II. Synthesis of tetrazole alkanamides and related compounds.
A series of tetrazole alkanamides was synthesized and tested for antiulcer activity against acetic acid-induced gastric ulcer in rats. These compounds were prepared by the reaction of tetrazole alkanoic acids and various amines by the mixed anhydride method or acid chloride method. Among them, 3-[(1-ethyl-5-tetrazolyl)methylthio]propionamide (IIn) was found to have the most potent activity. The structure-activity relationships are discussed.
Uchida
M
M
Komatsu
M
M
Morita
S
S
Kanbe
T
T
Nakagawa
K
K
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis*; D001393:Azoles / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000897:Anti-Ulcer Agents; D001393:Azoles; D013777:Tetrazoles