title: A second case of neonatal alloimmune thrombocytopenia associated with anti-PlA2 (Zwb) antibodies.
abstract: A case of neonatal alloimmune thrombocytopenia due to fetomaternal incompatibility against the platelet specific antigen PlA2 (Zwb) is described. Anti-PlA2 antibodies were present in the maternal serum together with anti-HLA antibodies. Initial identification of the platelet-specific antibodies was achieved by using chloroquine-treated PlA1(+) and PlA1(-) platelets. Antibody specificity was later confirmed using a panel of platelets of known phenotype.
authors.affiliation: Institute of Haematology, Warsaw, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Maslanka
authors.forename: G F
authors.initials: GF
authors.lastname: Lucas
authors.forename: A
authors.initials: A
authors.lastname: Gronkowska
authors.forename: J G
authors.initials: JG
authors.lastname: Davis
authors.forename: B
authors.initials: B
authors.lastname: Zupanska
mesh_terms: D000328:Adult; D016824:Antigens, Human Platelet; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn / Q000276:immunology*; D039661:Integrin beta3; D007518:Isoantibodies / Q000032:analysis*; D007519:Isoantigens / Q000276:immunology*; D008431:Maternal-Fetal Exchange; D010641:Phenotype; D011247:Pregnancy; D013921:Thrombocytopenia / Q000276:immunology*
chemical_list: D016824:Antigens, Human Platelet; D006680:HLA Antigens; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007518:Isoantibodies; D007519:Isoantigens