title: Methotrexate-associated, early-onset pancytopenia in rheumatoid arthritis.
abstract: A patient with rheumatoid arthritis presented with pancytopenia 3 weeks after initiation of low-dose methotrexate administered orally. She had minimal renal insufficiency and hypoalbuminemia prior to initiation of methotrexate therapy, and had received a nonsteroidal anti-inflammatory drug concurrently. Bone marrow recovery occurred within 3 weeks. Patients receiving low-dose methotrexate therapy for rheumatoid arthritis require early monitoring for bone marrow injury, especially those who have risk factors for possible methotrexate toxicity.
authors.affiliation: Department of Medicine, University of Kansas Medical Center, Kansas City 66103.
authors.forename: G C
authors.initials: GC
authors.lastname: Doolittle
authors.forename: K M
authors.initials: KM
authors.lastname: Simpson
authors.forename: H B
authors.initials: HB
authors.lastname: Lindsley
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D010198:Pancytopenia / Q000139:chemically induced*; D013997:Time Factors
chemical_list: D008727:Methotrexate