title: Specific serum IgA-antibodies in chlamydial-induced arthritis.
abstract: A cohort analytic study was performed to investigate serum IgA-class antibodies against Chlamydia in 24 patients with chlamydial-induced arthritis (CIA). IgA-class antibodies against chlamydial antigens were positive (titre greater than or equal to 1:16) in 23 of the 24 IgG-positive CIA-patients (96%) in contrast to 16 of 40 patients (40%) with other rheumatic diseases (ankylosing spondylitis n = 6; undifferentiated arthritis n = 11; rheumatoid arthritis n = 12; degenerative joint disease n = 11), also positive for IgG-class chlamydial antibodies. Both the presence of specific IgA-antibodies and their geometric mean titre (1:28 vs. 1:4) differed significantly (p less than 0.001) between the two groups.
authors.affiliation: Department of Endocrinology and Rheumatology, University Hospital, FRG.
authors.forename: H J
authors.initials: HJ
authors.lastname: Wollenhaupt
authors.forename: T
authors.initials: T
authors.lastname: Krech
authors.forename: C
authors.initials: C
authors.lastname: Schneider
authors.forename: H
authors.initials: H
authors.lastname: Zeidler
mesh_terms: D000328:Adult; D001170:Arthritis, Infectious / Q000175:diagnosis* / Q000276:immunology; D002690:Chlamydia Infections / Q000175:diagnosis* / Q000276:immunology; D002692:Chlamydia trachomatis / Q000276:immunology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D008297:Male; D008875:Middle Aged
chemical_list: D007070:Immunoglobulin A