2-substituted derivatives of benzimidazole inhibiting gastric acid secretion in rats.
Benzimidazole and its 2-derivatives with amino, carbamonitrile, urea, and guanidine groups have been tested for their activity on gastric secretory process. The carbamonitrile-, urea-, and guanidine compounds decrease gastric acid secretion, basal and stimulated with histamine or betazole, in Shay-rats and depress the guinea pig auricle activity stimulated by betazole. The results suggest that the studied 2-substituted benzimidazole compounds exhibit anti H2-histamine activity.
Pinelli
A
A
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy.
Trivulzio
S
S
Malvezzi
L
L
Rossoni
G
G
Beretta
L
L
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D001625:Betazole / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats
D001562:Benzimidazoles; D001625:Betazole; D006632:Histamine