title: Involvement of bands 9q21-q22 in five cases of acute nonlymphocytic leukemia.
abstract: Five patients with acute nonlymphocytic leukemia (ANLL) with chromosomal aberrations involving bands 9q21-q22 are described. The abnormalities were an interstitial deletion in two cases of ANLL FAB type M4 and M4 with eosinophilia, a terminal deletion in two cases of M4 and M5 type ANLL, and a translocation in an M2 ANLL. A review of reported cases of ANLL with abnormalities of chromosome 9 revealed a clustering of breaks at the region 9q21-q22, suggesting a possible role for these bands in leukemogenesis.
authors.affiliation: Cytogenetics Laboratory, Roswell Park Memorial Institute, Buffalo, New York.
authors.forename: C
authors.initials: C
authors.lastname: Sreekantaiah
authors.forename: M R
authors.initials: MR
authors.lastname: Baer
authors.forename: H D
authors.initials: HD
authors.lastname: Preisler
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
mesh_terms: D000328:Adult; D000368:Aged; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic