title: Anti-coccidial activity of human milk.
abstract: Sporozoites of Eimeria tenella, an important pathogen of poultry, were killed in vitro in a time- and concentration-dependent manner by exposure to diluted concentrations of normal human milk. Sodium cholate (bile salt stimulator) potentiated the anti-coccidial activity. The anti-coccidial activity was not found in the milk of lower mammals (cow, sheep, goat, dog). The component in human milk showing the activity was initially hypothesized to be a bile salt-stimulated lipase. However, testing of purified lipase (with or without sodium cholate) indicated no anti-coccidial activity. Consequently, we theorize that the active component may be a free fatty acid.
authors.affiliation: Upjohn Company, Kalamazoo, MI 49001.
authors.forename: S D
authors.initials: SD
authors.lastname: Folz
authors.forename: B L
authors.initials: BL
authors.lastname: Lee
authors.forename: L H
authors.initials: LH
authors.lastname: Nowakowski
authors.forename: C A
authors.initials: CA
authors.lastname: Winterrowd
authors.forename: G A
authors.initials: GA
authors.lastname: Conder
mesh_terms: D000818:Animals; D002417:Cattle; D004285:Dogs; D004539:Eimeria / Q000276:immunology*; D006041:Goats; D006801:Humans; D008892:Milk / Q000276:immunology; D008895:Milk, Human / Q000276:immunology*; D012756:Sheep