Kappa-bungarotoxin blockade of nicotine electrophysiological actions in cerebellar Purkinje neurons.
The agonistic actions of nicotine in cerebellum were selectively blocked by kappa-bungarotoxin depending on the cell type studied. Nicotine-induced Purkinje cell inhibitions were antagonized by the simultaneous application of this toxin. In contrast, nicotine-induced cerebellar interneuron excitations were unaltered. These findings suggest that kappa-bungarotoxin may be used as a selective pharmacological tool for the study of nicotine actions which are dependent on ganglionic-like receptors, which have been associated with Purkinje cells in previous studies.
de la Garza
R
R
Veterans Administration Medical Center, Denver, CO.
Freedman
R
R
Hoffer
B J
BJ
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002038:Bungarotoxins / Q000494:pharmacology*; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D011689:Purkinje Cells / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000502:physiology*
D002038:Bungarotoxins; D011978:Receptors, Nicotinic; D009538:Nicotine