Development of protection and of self-cure in lambs infected daily with Ostertagia circumcincta.
Lambs were infected daily with 1000 Ostertagia circumcincta larvae. At intervals of 4 weeks groups of lambs were each challenged with a dose of 28,000 larvae, and their worm burdens compared with those of unchallenged controls. The measure of their ability to resist a challenge infection, which would have determined their degree of "protection", was obscured by the separate phenomenon of self-cure. Evidence suggested that the different manifestations of self-cure were determined by the state of resistance of the host and followed a set chronological sequence.
Hong
C
C
Central Veterinary Laboratory, Weybridge, Surrey, Gt. Britain.
Michel
J F
JF
Lancaster
M B
MB
D000818:Animals; D005260:Female; D007110:Immunity, Active; D007814:Larva / Q000276:immunology; D008297:Male; D010028:Ostertagia / Q000276:immunology; D010029:Ostertagiasis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000469:parasitology; D013997:Time Factors; D014252:Trichostrongyloidiasis / Q000662:veterinary*