Studies on a novel antitumor antibiotic, phenazinomycin: taxonomy, fermentation, isolation, and physicochemical and biological characteristics.
A new antibiotic, phenazinomycin (C27H32N2O, MW 400), was isolated from the cultural mycelium of Streptomyces sp. WK-2057. This antibiotic possesses antibacterial activities against Gram-positive bacteria in vitro, direct cytotoxic activities against HeLa S3, P388 and P388 doxorubicin-resistant cells in vitro and antitumor activities against experimental murine tumors in vivo.
Omura
S
S
Kitasato Institute, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Eda
S
S
Funayama
S
S
Komiyama
K
K
Takahashi
Y
Y
Woodruff
H B
HB
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D006367:HeLa Cells; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008813:Mice, Inbred ICR; D008854:Microscopy, Electron; D015394:Molecular Structure; D010619:Phenazines / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D012510:Sarcoma 180 / Q000188:drug therapy*; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D010619:Phenazines; C060454:phenazinomycin