[Experiences with intra-arterial tumor chemotherapy of malignant liver tumors via totally implantable catheter systems].
Locoregional chemotherapy was applied to 30 patients for isolated, surgically not removable liver tumours (13 colorectal carcinomas, 17 carcinomas on different sites). Ten patients were in Stage I, 16 in Stage II, and four in Stage III. Cytostatics were administered through totally implantable catheter systems. The following therapeutic protocol was mainly used: 5-flourouracil 800-1,000 mg/m2/3hr/die X 5 in 22 days, adriamycin 30 mg/m2/3 hr/die X 2 in 22 days. The average time of treatment amounted to ten months. Cytotoxis side effects were of minor importance. Hepatic side effects, such as chemical hepatitis or sclerosing cholangitis, were not recordable. Reduction of tumour size by 50 percent or more was recorded by computed tomography from 14 cases (46.6 percent). The objectivated rate of responsiveness in patients with colorectal carcinoma was 61.5 percent. The average period up to progression amounted to 12.1 months. Premortal spreading of the disease beyond the liver was recorded from six patients.
Matthias
M
M
Klinik für Chirurgie, Bereichs Medizin (Charité) der Humboldt-Universität zu Berlin.
Ridwelski
K
K
Wolff
H
H
Preiss
R
R
Sperling
P
P
Lüning
M
M
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000069461:Bendamustine Hydrochloride; D002408:Catheters, Indwelling; D003606:Dacarbazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004341:Drug Evaluation; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007260:Infusion Pumps; D007261:Infusions, Intra-Arterial / Q000295:instrumentation*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D009588:Nitrogen Mustard Compounds / Q000008:administration & dosage
D000970:Antineoplastic Agents; D009588:Nitrogen Mustard Compounds; D003606:Dacarbazine; D004317:Doxorubicin; D000069461:Bendamustine Hydrochloride; D005472:Fluorouracil
Erfahrungen mit der intraarteriellen Tumorchemotherapie maligner Lebertumoren über total implantierbare Kathetersysteme.