title: [Bolus and maintenance infusion of high-dose methotrexate].
abstract: For 17 patients with bone and soft tissue sarcoma, 32 bolus and maintenance infusions of high-dose methotrexate (MTX) were performed to induce rapid elevation of plasma MTX concentration and to maintain it. At the doses of 200-300 mg/kg, plasma MTX concentrations were measured by enzyme assay. It needed four hours to reach the steady state by five hours' constant rate infusion, with the plasma plateau concentration at about 1 X 10(-3) M/L. On the other hand, bolus infusion of MTX needed only one hour to reach over 5 X 10(-4) M/L, and the plateau concentration lasted during the maintenance infusion period. By the constant rate infusion as well as bolus infusion, it was possible to maintain the plasma concentration over 1 X 10(-4) M/L for 12 hours, but both infusions can not maintain 1 X 10(-3) M/L for a long time. From these results, clinical effects of high dose MTX against sarcomas seemed to be evaluated by the plasma MTX plateau concentration and the maintenance time.
authors.affiliation: Dept. of Orthopedic Surgery, Cancer Institute Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Amino
authors.forename: N
authors.initials: N
authors.lastname: Kawaguchi
authors.forename: S
authors.initials: S
authors.lastname: Matsumoto
authors.forename: J
authors.initials: J
authors.lastname: Manabe
authors.forename: D
authors.initials: D
authors.lastname: Tabata
authors.forename: M
authors.initials: M
authors.lastname: Machida
mesh_terms: D001859:Bone Neoplasms / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D008727:Methotrexate / Q000008:administration & dosage* / Q000097:blood; D012509:Sarcoma / Q000097:blood / Q000188:drug therapy*; D012983:Soft Tissue Neoplasms / Q000097:blood / Q000188:drug therapy*
chemical_list: D008727:Methotrexate