[Hemodynamic effects of verapamil in pulmonary hypertension caused by heart valve disease].
The authors have investigated the haemodynamic effects of verapamil on the pulmonary circulation by 24 patients suffering from secondary pulmonary hypertension, caused by mitral and/or aortic valve diseases. For this purpose the numeric and graphometric analysis of intracavitary right ventricle pressure curve and pulmonary artery pressure tracing was applied. It was observed a selective antihypertensive effect on the lesser circulation. The pulmonary and systemic systolic tension decreased comparing in percentage 3:1, in case of diastolic tension this comparison was 2:1. The decrease in pulmonary circulation was strongly significant. The diminishing of heart rate and the improving of right heart function was not significant. The elevation of end-diastolic pressure of the right ventricle, just as the shape-analysis of pressure curves suggested right ventricle overload.
Marozsán
I
I
Szatmáry
L
L
Kelemen
S
S
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006349:Heart Valve Diseases / Q000150:complications*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology / Q000627:therapeutic use*
D014700:Verapamil
Verapamil haemodinamikai hatásainak vizsgálata billentyübetegségek kapcsán kialakult pulmonalis hypertoniában.