title: Influence of inherent directional biases on neurochemical consequences of conditioned circling.
abstract: High rates of conditioned circling have been associated with a bilateral increase in striatal (STR) dopamine (DA) metabolism in rats. Experiments 1 and 2 examined the extent to which inherent directional biases, which are critical in determining the magnitude and direction of drug-induced circling, would influence the acquisition and performance of conditioned circling. No behavioral effects were evident. However, a symmetrical bilateral enhancement in DA metabolism was observed in the STR irrespective of directional biases. These results provide further evidence for the bilateral involvement of the mesotelencephalic DA projection in conditioned circling. Although conditioned circling could be established and maintained by reinforcing the response with food (Experiment 3), food itself influenced DA metabolism and therefore precluded the detection of changes in DA metabolism specific to the circling response. Specifically, DA metabolism was augmented to a similar extent in animals given noncontingently presented food.
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Szostak
authors.forename: A
authors.initials: A
authors.lastname: Jakubovic
authors.forename: A G
authors.initials: AG
authors.lastname: Phillips
authors.forename: H C
authors.initials: HC
authors.lastname: Fibiger
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001143:Arousal / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D009830:Olfactory Bulb / Q000502:physiology; D009949:Orientation / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D012686:Septal Nuclei / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology*
chemical_list: D011954:Receptors, Dopamine; D015102:3,4-Dihydroxyphenylacetic Acid; D000661:Amphetamine; D004298:Dopamine; D006719:Homovanillic Acid