title: [Safety and efficacy of an antirabies vaccine consisting of recombinant vaccinia-rabies virus administered orally to the fox, dog and cat].
abstract: One of the most promising ways to control rabies in wildlife seems to be the distribution of bait containing an anti-rabies vaccine. So far, the most widely used vaccines were modified live viruses (SAD strain or derivatives). Nevertheless, these strains retain some pathogenicity for non-target species. A novel vaccine was proposed consisting of genetically modified vaccinia virus (strain Copenhagen, thermosensitive ts 26) expressing the foreign glycoprotein G for the rabies virus (strain ERA). Different doses of this recombinant virus were administered orally to 59 foxes (Vulpes vulpes) and their antibodies were titrated before challenge. Foxes (8/8) resisted 1 month after vaccination with 10(7) plaque forming units (PFU), or 4/4 after 18 months. Seroconversion among dogs was 4/4 after vaccination with 10(9,6) PFU and 4/4 among cats after vaccination with 10(8) PFU. These dogs (4/4) and cats (3/4) resisted the challenge 2-3 months after vaccination. This vaccine thus appears to be potent and safe in these species. Its properties are discussed.
authors.affiliation: CNEVA, Laboratoire d'Etudes sur la Rage et la Pathologie des Animaux Sauvages, Malzéville, France.
authors.forename: J
authors.initials: J
authors.lastname: Blancou
authors.forename: M
authors.initials: M
authors.lastname: Artois
authors.forename: B
authors.initials: B
authors.lastname: Brochier
authors.forename: I
authors.initials: I
authors.lastname: Thomas
authors.forename: P P
authors.initials: PP
authors.lastname: Pastoret
authors.forename: P
authors.initials: P
authors.lastname: Desmettre
authors.forename: B
authors.initials: B
authors.lastname: Languet
authors.forename: M P
authors.initials: MP
authors.lastname: Kiény
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000835:Animals, Wild; D002415:Cats; D004285:Dogs; D004341:Drug Evaluation; D005589:Foxes; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage*; D011820:Rabies virus; D011994:Recombinant Proteins; D014616:Vaccinia virus
chemical_list: D011819:Rabies Vaccines; D011994:Recombinant Proteins
vernacular_title: Innocuité et efficacité d'un vaccin antirabique recombinant des virus de la vaccine et de la rage administré par voie orale au renard, au chien et au chat.