title: Effects of benfluron metabolites on glycolysis and level of thiol groups in P388 and Ehrlich ascites cells.
abstract: The effects of two benfluron metabolites, namely 7-dihydrobenfluron (DBF) and N-oxide of benfluron (NOBF), on the aerobic glycolysis of Ehrlich ascites carcinoma (EAC) and P388 cells were studied. Also their effect on the level of total (T-SH) and nonprotein (NP-SH) thiol groups was investigated. A significant inhibition of aerobic glycolysis in the presence of NOBF was found only in P388 cells. Both metabolites decreased more significantly the level of NP-SH than that of T-SH.
authors.affiliation: Department of Microbiology and Biochemistry, Slovak Polytechnical University, Bratislava, Czechoslovakia.
authors.forename: M
authors.initials: M
authors.lastname: Miko
authors.forename: J
authors.initials: J
authors.lastname: Krepelka
authors.forename: M
authors.initials: M
authors.lastname: Mĕlka
authors.forename: D
authors.initials: D
authors.lastname: Vajdová
mesh_terms: D000332:Aerobiosis; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002460:Cell Line; D005449:Fluorenes / Q000378:metabolism* / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D007773:Lactates / Q000378:metabolism; D007941:Leukemia P388 / Q000378:metabolism*; D007942:Leukemia, Experimental / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000032:analysis*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D005449:Fluorenes; D007773:Lactates; D013438:Sulfhydryl Compounds; C034234:VUFB 13468; C059231:7-dihydrobenfluron; C059230:benfluron N-oxide; D005947:Glucose