title: [Disorders of the system of regulation of the aggregative status of the blood in patients with thromboangiitis obliterans of the lower extremities].
abstract: Predominantly regional disorders of blood aggregation control, aggravating with the progress of ischemia, were detected in patients with obliterating thromboangiitis of the legs. Local overstrain and exhaustion of compensatory anticoagulation and thrombolytic factors developed in the presence of critical ischemia of the limbs and were accompanied by developing regional prethrombotic state. Regional administration (intra-arterial infusions) of anticoagulants and thrombolytic agents appears to be the most justified line of remedial therapy in these patients.
authors.forename: V M
authors.initials: VM
authors.lastname: Bykov
authors.forename: E A
authors.initials: EA
authors.lastname: Birman
authors.forename: O I
authors.initials: OI
authors.lastname: Kolobova
mesh_terms: D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D006801:Humans; D007511:Ischemia / Q000097:blood* / Q000150:complications; D007866:Leg / Q000098:blood supply*; D008875:Middle Aged; D010974:Platelet Aggregation; D013919:Thromboangiitis Obliterans / Q000097:blood* / Q000150:complications; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology*
vernacular_title: Narusheniia v sisteme reguliatsii agregatnogo sostoianiia krovi u bol'nykh obliteriruiushchim tromboangiitom nizhnikh konechnosteĭ.