Nifedipine and amphotericin B nephrotoxicity in the rat.
Amphotericin B nephrotoxicity limits its therapeutic use. The mechanisms involved in the deleterious effect on the kidney include a preglomerular vasoconstriction. Nifedipine, a calcium antagonist which acts also on the afferent arteriolar tone, did not, however, prevent renal impairment in the rats of our study. This could be due either to a negligible role of the hemodynamic changes in the development of renal failure or to a lack of efficacy of nifedipine on the vasoconstrictor mechanism induced by amphotericin B.
Soupart
A
A
Department of Internal Medicine, Erasmus University Hospital, Belgium.
Decaux
G
G
D000666:Amphotericin B / Q000009:adverse effects*; D000818:Animals; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced* / Q000188:drug therapy; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats
D000666:Amphotericin B; D009543:Nifedipine