Acute resin phenol-formaldehyde intoxication. A life threatening occupational hazard.
1. A 38-year-old previously healthy worker accidentally spilled phenol-formaldehyde resin over a large area of his skin. 2. Several days later he was hospitalized with extensive necrotic skin lesions, fever, hypertension, adult respiratory distress syndrome (ARDS), proteinuria and renal functional impairment. 3. All symptoms improved progressively and eventually disappeared. 4. We propose that toxic materials originating from the necrotic skin lesions and the continued facilitated absorption of the resin and/or its components via the skin lesions were the main factors responsible for this alarming multisystem involvement. 5. Workers handling this material should be instructed to take appropriate precautions and physicians should be alerted to the potential pathophysiological consequences.
Cohen
N
N
Department of Medicine A, Assaf Harofeh Medical Center, Tel-Aviv University, Zerifin, Israel.
Modai
D
D
Khahil
A
A
Golik
A
A
D000328:Adult; D005557:Formaldehyde / Q000493:pharmacokinetics / Q000506:poisoning*; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D010636:Phenols / Q000493:pharmacokinetics / Q000506:poisoning*; D011108:Polymers / Q000493:pharmacokinetics / Q000506:poisoning*; D011859:Radiography; D012128:Respiratory Distress Syndrome / Q000139:chemically induced
D010636:Phenols; D011108:Polymers; D005557:Formaldehyde; C011529:phenol-formaldehyde resin