Metyrapone decreases the glutathione concentration in liver and kidney.
A single dose of 7.5 mg/100 g b.wt. metyrapone, intraperitoneally, decreased the concentration of reduced (GSH) and oxidized (GSSG) glutathione in the liver and kidney of female Wistar rats for approximately 4-5 h. The ratio between GSSG and GSH was not affected in the kidney but is decreased in the liver.
Appenroth
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Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, GDR.
Seidel
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D000818:Animals; D005260:Female; D005978:Glutathione / Q000031:analogs & derivatives / Q000378:metabolism*; D019803:Glutathione Disulfide; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008797:Metyrapone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D005978:Glutathione; D019803:Glutathione Disulfide; D008797:Metyrapone