title: Clinical profile of Indian non-insulin-dependent diabetics with nephropathy and renal failure.
abstract: We studied the clinical profile of 296 non-insulin-dependent diabetic (NIDDM) patients with nephropathy and renal failure. Male preponderance was striking in this group and the age of onset of diabetes was between 30 and 50 years in 75%. Retinopathy was present in 86% with proliferative changes in 20% and coronary artery disease was evident in 40% of the patients. The incidence of retinopathy and coronary artery disease was significantly higher in this group than in a group of non-insulin-dependent diabetics without nephropathy (86% vs. 18.5%; 40% vs. 30% respectively, P less than 0.01). It is our observation that patients with NIDDM developing nephropathy and renal failure have had an early onset of disease and are significantly more often male. There is also a greater incidence of elevated blood pressure, coronary artery disease and retinopathy in this group.
authors.affiliation: Department of Medicine, Christian Medical College Hospital, Vellore, India.
authors.forename: L
authors.initials: L
authors.lastname: John
authors.forename: A
authors.initials: A
authors.lastname: Ganesh
authors.forename: G
authors.initials: G
authors.lastname: John
authors.forename: J M
authors.initials: JM
authors.lastname: Raju
authors.forename: M G
authors.initials: MG
authors.lastname: Kirubakaran
authors.forename: J C
authors.initials: JC
authors.lastname: Shastry
mesh_terms: D000328:Adult; D000367:Age Factors; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007194:India; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors