title: Activity of ICI 195,739, a new oral triazole, compared with that of ketoconazole in the therapy of experimental murine blastomycosis.
abstract: ICI 195,739, a novel orally active triazole, proved 50 times as potent as ketoconazole, produced a clinical cure, and completely eradicated residual infection in a murine model of pulmonary blastomycosis. No other previously tested azole has shown similar activity. Fungicidal activity against Blastomyces dermatitidis was seen in vitro at concentrations 1/40 of those achieved in serum with protective doses.
authors.affiliation: Department of Medicine, Santa Clara Valley Medical Center and Institute for Medical Research, San Jose, California 95128.
authors.forename: R M
authors.initials: RM
authors.lastname: Tucker
authors.forename: L H
authors.initials: LH
authors.lastname: Hanson
authors.forename: E
authors.initials: E
authors.lastname: Brummer
authors.forename: D A
authors.initials: DA
authors.lastname: Stevens
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001758:Blastomyces / Q000187:drug effects; D001759:Blastomycosis / Q000188:drug therapy* / Q000382:microbiology; D007654:Ketoconazole / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors; D014230:Triazoles / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C058219:ICI 195739; D007654:Ketoconazole