Thyroid hormones and the acquisition and retention of behavioural responses.
Naive rats placed in a plexiglass cylinder from a 15 minute test period show progressive immobility, and retain the immobile response when given a 5-minute retest 24 hours later. In the present study we show that hypothyroidism markedly attenuates the acquisition of the immobile response; that this effect on acquisition is reversed 5-10 minutes after the administration of thyroxine; and that hypothyroid rats treated with a single dose of thyroxine up to 2 hours after the initial test show levels of immobility on re-test indistinguishable from intact rats.
Jefferys
D
D
Medical Research Centre, Prince Henry's Hospital, Melbourne, Australia.
Funder
J W
JW
D000284:Administration, Oral; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D007037:Hypothyroidism / Q000503:physiopathology; D007273:Injections, Intramuscular; D008297:Male; D011441:Propylthiouracil / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013963:Thyroid Hormones / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D013974:Thyroxine / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology; D013997:Time Factors; D014284:Triiodothyronine / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology
D013963:Thyroid Hormones; D014284:Triiodothyronine; D011441:Propylthiouracil; D013974:Thyroxine