Development of an in vivo model for assessment of drug-induced vascular injury.
Thrombophlebitis is a common complication associated with infusion of intravenous sedatives, especially diazepam. Development of a technique for evaluation of drug-induced histopathologic changes in animal tissues should allow for more precise study of methods and agents which might be used clinically to minimize the thrombophlebitic phenomena. In this study, the authors describe the use of the marginal ear vein of the rabbit as a model for studying drug-induced thrombophlebitis, as well as techniques for reducing or preventing it.
Johnson
J V
JV
Department of Oral and Maxillofacial Surgery, University of Texas Dental Branch, Houston 77225.
Jeske
A H
AH
McDaniel
H K
HK
Herrera
G Q
GQ
D000818:Animals; D003975:Diazepam / Q000009:adverse effects*; D004195:Disease Models, Animal; D004423:Ear / Q000098:blood supply*; D005260:Female; D007262:Infusions, Intravenous / Q000009:adverse effects*; D008012:Lidocaine / Q000008:administration & dosage; D008297:Male; D011292:Premedication; D011817:Rabbits; D012965:Sodium Chloride / Q000008:administration & dosage; D013924:Thrombophlebitis / Q000139:chemically induced* / Q000517:prevention & control; D014680:Veins / Q000473:pathology
D012965:Sodium Chloride; D008012:Lidocaine; D003975:Diazepam