title: Induction of theophylline metabolism by pentobarbital.
abstract: Theophylline concentrations in plasma and urine were determined during maintenance treatment in nine healthy volunteers during one dosage interval before and after 10 days of simultaneous treatment with pentobarbital (100 mg each night). During the pentobarbital period, total plasma clearance of theophylline increased by 40% (range -4-79%), whereas renal clearance remained unchanged. It is concluded that therapeutic doses of pentobarbital induce the metabolism of theophylline with marked interindividual variation.
authors.affiliation: Department of Clinical Pharmacology, Huddinge University Hospital, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Dahlqvist
authors.forename: E
authors.initials: E
authors.lastname: Steiner
authors.forename: Y
authors.initials: Y
authors.lastname: Koike
authors.forename: C
authors.initials: C
authors.lastname: von Bahr
authors.forename: M
authors.initials: M
authors.lastname: Lind
authors.forename: B
authors.initials: B
authors.lastname: Billing
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D013806:Theophylline; D010424:Pentobarbital