title: Low-dose 5-fluorouracil and glaucoma filtration surgery.
abstract: We show that a 40-mg total dose of subconjunctival 5-fluorouracil after glaucoma filtering surgery can provide a success rate comparable to that demonstrated in prior studies employing a higher dose. Sixty-four eyes with poor prognoses underwent filtering surgery with postoperative subconjunctival injections of 5 mg of 5-fluorouracil daily for seven days followed by one injection 1 week later. In 75% percent of the eyes intraocular pressure stabilized at 21 mm Hg or less regardless of medications used. The majority of failures occurred within 6 months of treatment. Postoperative corneal epithelial defects occurred in 30% of the cases, conjunctival wound leaks in 6.3%. A 40-mg dose of subconjunctival 5-fluorouracil appears to be effective and may be associated with a lower incidence of postoperative complications than higher doses.
authors.affiliation: Department of Ophthalmology, Northwestern University Medical School, Chicago, Ill. 60611.
authors.forename: J H
authors.initials: JH
authors.lastname: Rabowsky
authors.forename: J M
authors.initials: JM
authors.lastname: Ruderman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003315:Cornea / Q000473:pathology; D004847:Epithelial Cells; D005472:Fluorouracil / Q000008:administration & dosage*; D005500:Follow-Up Studies; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure / Q000187:drug effects; D008875:Middle Aged; D011183:Postoperative Complications; D013997:Time Factors; D014792:Visual Acuity
chemical_list: D005472:Fluorouracil