Acute nonlymphocytic leukemia with basophilic differentiation and t(9,11)(p22,q23) in a child.
A 20-month-old child was treated for acute nonlymphocytic leukemia (ANLL) with basophilic differentiation. His leukemic cells also had the cytogenetic abnormality of t(9,11)(p22,q23). Although immature blasts responded well to induction therapy with etoposide, the leukemic cells that were more differentiated toward basophils were quite refractory to the drug. However, complete remission was finally achieved with a conventional multidrug regimen.
Kubota
M
M
Department of Pediatrics, Kyoto University, Japan.
Akiyama
Y
Y
Tabata
Y
Y
Yoshigi
M
M
Mikawa
H
H
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001491:Basophils / Q000473:pathology*; D002454:Cell Differentiation; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D002899:Chromosomes, Human, Pair 9; D005047:Etoposide / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D014178:Translocation, Genetic
D005047:Etoposide