Bioactivity of the essential oil of Bupleurum fruticosum.
The essential oil of Bupleurum fruticosum was investigated qualitatively and quantitatively together with the anti-inflammatory activity of the whole essential oil and its major components. In addition, antispasmodic activity was determined in rat uterus preparations using acetylcholine and oxytocin as agonists. The anti-inflammatory activity shown by the essential oil can be attributed in part to the two major components, alpha-pinene and beta-pinene, although the presence of thymol and carvacrol, minor components capable of potentiating the action of these hydrocarbons, was also confirmed.
Lorente
I
I
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Granada, Spain.
Ocete
M A
MA
Zarzuelo
A
A
Cabo
M M
MM
Jimenez
J
J
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D066298:In Vitro Techniques; D009822:Oils, Volatile / Q000494:pharmacology*; D010121:Oxytocin / Q000037:antagonists & inhibitors; D010276:Parasympatholytics; D010944:Plants / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009822:Oils, Volatile; D010276:Parasympatholytics; D010121:Oxytocin; D002351:Carrageenan; D000109:Acetylcholine