[Delayed type hypersensitivity reaction in the pathogenesis and formation of immunity in tularemia infections in mice].
As a result of our studies, strain differences in the sensitivity of CBA and BALB/c mice to partially attenuated Francisella tularensis strain have been revealed. Relationship between the increased migration of lymphocytes to the liver and lymphoid organs and the intensive development of cell-mediated immunity reactions has been shown. An important role of local reactions (the skin at the site of the inoculation of F. tularessis + a regional lymph node) in the development of the pathological process and the formation of immunity to tularemia infection has been noted. A high level of resistance to F. tularensis strain used for inoculation in BALB/c mice seems to be greatly due to the fact that in these mice more intensive cell-mediated immunity reactions develop at the early stages of infection, than in CBA mice.
Gordeeva
M S
MS
Savel'eva
R A
RA
D000818:Animals; D000917:Antibody Formation; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000276:immunology; D007111:Immunity, Cellular; D008099:Liver / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008221:Lymphoid Tissue / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D013045:Species Specificity; D014406:Tularemia / Q000276:immunology* / Q000473:pathology
Reaktsiia giperchuvstvitel'nosti zamedlennogo tipa v patogeneze i formirovanii immuniteta pri tuliaremiĭnoĭ infektsii u mysheĭ.