[Hemodynamic effects of dobutamine, dopamine and methoxamine during thoracic epidural anesthesia in dogs with coronary stenosis].
Dobutamine (DOB), dopamine (DOP) and methoxamine (MEX) were compared as to their effectiveness in controlling circulatory depression caused by thoracic epidural anesthesia in dogs with instituted coronary stenosis. DOB appeared to best serve the purpose of reestablishing systemic circulation, notably with an elevation of blood pressure. DOP achieved the best restoration of the absolute value of regional myocardial blood flow (RMBF), but DOB and DOP both caused RMBF in stenosed and non-stenosed areas to increase to virtually the same extent, and furthermore, worsened the intramyocardial distribution of RMBF in stenosed area. With MEX, an alpha-stimulant, there was noted a significant increase in blood flow through a stenosed area and, moreover, the increment tended to be greater than in a non-stenosed area, a fact suggesting involvement of such a mechanism as reverse coronary steal.
Kitahata
H
H
Shinohara
S
S
D000767:Anesthesia, Epidural; D000818:Animals; D003250:Constriction; D003251:Constriction, Pathologic / Q000503:physiopathology; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology*; D003331:Coronary Vessels; D004280:Dobutamine / Q000494:pharmacology*; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D008729:Methoxamine / Q000494:pharmacology*
D004280:Dobutamine; D008729:Methoxamine; D004298:Dopamine