title: Clonal chromosome aberrations in a keratoacanthoma and a basal cell papilloma.
abstract: Clonal chromosome abnormalities were found in short-term cultures from two epithelial skin tumors, a basal cell papilloma and a keratoacanthoma. The three-way translocation t(2;6;11)(q21;q27;p13) was the sole clonal rearrangement in the basal cell papilloma. The karyotype of the keratoacanthoma was more complex: 46,XX,der(2)(2pter----2p13::2p11----cen----2q37: :5q33----5qter),der(2) (:2p13----cen----2q37::6q23----6qter),der(5)t(2; 7;5)(q37;q11;q33),der(6) (6pter----cen----6q23::2p13----2pter),der(7)t(2; 7;5)(q37;q11;q33), del(13)(q11q14). In addition, several nonclonal structural changes were seen in both tumors.
authors.affiliation: Department of Clinical Genetics, University Hospital, Lund, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Mertens
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: B
authors.initials: B
authors.lastname: Johansson
authors.forename: A
authors.initials: A
authors.lastname: Rydholm
authors.forename: A
authors.initials: A
authors.lastname: Biörklund
authors.forename: J
authors.initials: J
authors.lastname: Wennerberg
authors.forename: N
authors.initials: N
authors.lastname: Jonsson
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D007636:Keratoacanthoma / Q000235:genetics* / Q000473:pathology; D012871:Skin Diseases / Q000235:genetics* / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology