[Effect of sex hormones on the induction of renal capsule angiosarcomas in mice].
Pararenal angiosarcomas appear in CBA male mice treated with 1,2-dimethylhydrazine (DMH). No such tumours appeared in the intact females treated with DMH alone. Testosterone propionate (TP) given in combination with DMH (28%) was efficient in the incidence of DMH-induced pararenal tumours in females. Pararenal angiosarcomas appeared in 92% of castrated CBA female mice under combined treatment with DMH and TP. No such tumours appeared in C57B1 males treated under the same experimental conditions.
Chemeris
G Iu
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D019813:1,2-Dimethylhydrazine; D000818:Animals; D002369:Castration; D004127:Dimethylhydrazines; D004347:Drug Interactions; D004958:Estradiol / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D006394:Hemangiosarcoma / Q000139:chemically induced* / Q000453:epidemiology; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012727:Sex Characteristics; D013739:Testosterone / Q000633:toxicity*
D004127:Dimethylhydrazines; D013739:Testosterone; D004958:Estradiol; D019813:1,2-Dimethylhydrazine; C023482:estradiol dipropionate
Vliianie polovykh gormonov na induktsiiu angiosarkom pochechnoĭ kapsuly u mysheĭ.