Astrocytes induce dendritic development in cultured sympathetic neurons.
Sympathetic neurons in culture require the influence of Schwann cells in order to develop dendrites comparable to those seen in vivo. This study demonstrates that astrocytes induce dendritic development in greater than 90% of sympathetic neurons after two weeks of co-culture. We conclude that dendrite inducing factors are distributed on both central and peripheral glia.
Johnson
M I
MI
Department of Pediatrics and Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110.
Higgins
D
D
Ard
M D
MD
D000818:Animals; D001253:Astrocytes / Q000166:cytology* / Q000502:physiology*; D002470:Cell Survival; D002478:Cells, Cultured; D003712:Dendrites / Q000502:physiology*; D005728:Ganglia, Sympathetic / Q000166:cytology* / Q000502:physiology; D051381:Rats