Maternal and fetal chromosomal aberrations in mice following prenatal exposure to subembryotoxic doses of lead nitrate.
Maternal exposure to low levels of lead nitrate (12.5, 25, 50 mg/kg body weight), administered on the 9th day of gestation, did not cause embryonic resorption and fetal lethality, but induced chromosomal deletions and other forms of aberrations in fetal liver and maternal bone marrow cells.
Nayak
B N
BN
Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Ray
M
M
Persaud
T V
TV
D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure*; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002877:Chromosomes, Human / Q000648:ultrastructure*; D004305:Dose-Response Relationship, Drug; D020964:Embryo Loss / Q000139:chemically induced; D005260:Female; D005328:Fetal Viability / Q000187:drug effects; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000196:embryology / Q000648:ultrastructure; D008431:Maternal-Fetal Exchange; D051379:Mice; D008813:Mice, Inbred ICR; D009566:Nitrates / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy
D009566:Nitrates; D007854:Lead; C017461:lead nitrate