title: Effect of a steroidal (prednisolone) and nonsteroidal (indomethacin) antiinflammatory agent on ovulation and follicular accumulation of prostaglandin F2 alpha in sheep.
abstract: The antiinflammatory steroid, prednisolone, was administered to sheep during the preovulatory period. The drug did not produce a blockade of follicular rupture. However, prednisolone negated a rise in production of prostaglandin (PG) F2 alpha characteristic of preovulatory follicles. Indomethacin, a nonsteroidal antiinflammatory agent, was 100% effective in preventing ovulation. Levels of PGF2 alpha within follicular tissue were very low following treatment with indomethacin. These findings indicate that ovulation can occur in the absence of a preovulatory elevation in follicular accumulation of PGF2 alpha. Potency of antiinflammatory drugs as inhibitors of ovulation appears to hinge upon their ability to cause a marked suppression in follicular synthesis of prostaglandins.
authors.affiliation: Department of Animal Science, University of Wyoming, Laramie 82071.
authors.forename: W J
authors.initials: WJ
authors.lastname: Murdoch
mesh_terms: D000818:Animals; D015237:Dinoprost / Q000378:metabolism*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D006080:Ovarian Follicle / Q000187:drug effects / Q000378:metabolism*; D010060:Ovulation / Q000187:drug effects*; D011239:Prednisolone / Q000494:pharmacology*; D012756:Sheep; D013997:Time Factors
chemical_list: D011239:Prednisolone; D015237:Dinoprost; D007213:Indomethacin