Calcium and calmodulin antagonism for inhibition of uterine contractions.
In search for a new tocolytic agent we investigated felodipine, a calmodulin-antagonizing drug. Felodipine reduced the spontaneous activity of 22 uterine strips taken from the uterus in the course of a cesarean section to 52 +/- 12% (mean +/- SEM) after 10 min, to 20 +/- 7% after 20 min and to 12 +/- 4% after 60 min (P less than 0.001).
Lechner
W
W
Department of Obstetrics and Gynecology, University of Innsbruck, Austria.
Keene
F
F
Marth
C
C
Zech
J
J
D002118:Calcium / Q000502:physiology*; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D046508:Culture Techniques; D004110:Diltiazem / Q000494:pharmacology*; D015736:Felodipine; D005260:Female; D006801:Humans; D009568:Nitrendipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011247:Pregnancy; D014590:Uterine Contraction / Q000187:drug effects*
D002147:Calmodulin; D009568:Nitrendipine; D004110:Diltiazem; D015736:Felodipine; D002118:Calcium