[Structure of the mesenteric lymph nodes in fetuses and offspring of white rats under the effect of indomethacin on the mother-fetus system].
Mesenteric lymph nodes in fetuses and offspring of white rats have been studied during various age periods after indomethacin injection in doses 2.5 mg/kg and 1 mg/kg daily from the 18th up to 21st day of pregnancy. Dose-dependent retardation in formation of main structures of the mesenteric lymph nodes, decreasing amount of the lymphoid type cells have been revealed. Retardation in the capsule, sinuses and reticular fibers of the node takes place, as well as decrease in lympho- and plasmocytopoiesis. It is more pronounced after indomethacin in dose 2.5 mg/kg. Simultaneously, formation of the cerebral substance and appearance of lymphoid nodules and their germinative centers are delayed. After the drug effect (2.5 mg/kg), up to the age of 2 weeks the amount of tissue basophils and eosinophilic granulocytes decreases. When the dose of the drug is 1 mg/kg decreasing amount of these cells is substituted for their compensatory increase on the 2d-3d week. The data obtained demonstrate a decreasing function of the lymph nodes, that depends on the dose of indomethacin.
Morozova
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EV
D000818:Animals; D001772:Blood Cell Count; D005260:Female; D005333:Fetus / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology*; D008198:Lymph Nodes / Q000033:anatomy & histology* / Q000187:drug effects / Q000196:embryology; D008214:Lymphocytes / Q000187:drug effects; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
D007213:Indomethacin
Stroenie bryzheechnykh limfaticheskikh uzlov u plodov i potomstva belykh krys pri vozdeĭstvii indometatsina na sistemu mat'-plod.