title: Lithium alters the stereoselectivity of monoamine oxidase in rat brain.
abstract: The effects of lithium on monoamine oxidase (MAO) in rat brain were studied in the presence of each enantiomer of tranylcypromine [(+)- and (-)-TCP]. The (+)-enantiomer was 25 times more potent than its antipode as MAO inhibitor. Lithium enhanced the inhibitory effect of (-)-TCP on MAO, but it did not affect actions of the (+)-enantiomer. Moreover, lithium influenced the stereoselective index for MAO, which suggests that lithium altered conformational features of the enzyme.
authors.affiliation: Aarhus University Institute of Psychiatry, Psychiatric Hospital, Risskov, Denmark.
authors.forename: D F
authors.initials: DF
authors.lastname: Smith
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D014191:Tranylcypromine / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D014191:Tranylcypromine; D008094:Lithium; D008995:Monoamine Oxidase