Antihypoxic effects of AWD 23-15 in mice and rats.
AWD 23-15 (6-Methyl-1,2,3,4-tetrahydro-pyrimidin-2,4 dion) which is known to improve learning and memory processes in laboratory animals, was investigated in several hypoxia models. The following results were obtained: 1. Increase of survival rate, 2. change in hypoxia-induced decrease of cerebral post-mortem adenylic energy charge and in concentrations of metabolic products in the brain and 3. antagonism of the hypoxia-induced decrease of dopamine release. However in the general behavioral test the drug was ineffective. These results support the idea that AWD 23-15 is a potential nootropic drug.
Morgenstern
E
E
Institute of Pharmacological Research, Berlin, GDR.
Rostock
A
A
Siegemund
C
C
Göres
E
E
Bartsch
R
R
Wustmann
C
C
Fischer
H D
HD
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology
D000227:Adenine Nucleotides; D014498:Uracil; C008378:6-methyluracil; D005947:Glucose