[Effect of dopamine on the blood circulation and metabolism in the brain during ischemia].
In acute experiments on anesthetized cats under blood autoperfusion of cerebral and peripheral vessels with a stable volume of blood during cerebral ischemia there was revealed the vascular and metabolic effects of dopamine on cerebral circulation. Administration of dopamine by perfusion in a dose of 100 micrograms/kg/min for 35 min after ischemia inhibited the development of postischemic hypoperfusion of the brain and also eliminated postischemic hypotension. A significant effect of dopamine on oxidative metabolism of the brain was observed.
Pchelintseva
T R
TR
Pogorelyĭ
V E
VE
Gaevyĭ
M D
MD
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004298:Dopamine / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005947:Glucose / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008297:Male; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D010477:Perfusion / Q000379:methods; D013997:Time Factors
D005947:Glucose; D010100:Oxygen; D004298:Dopamine
Vliianie dofamina na krovoobrashchenie i metabolizm v golovnom mozge v usloviiakh ishemii.