Modulation of cis-dichlorodiammineplatinum(II)-induced cytotoxicity by benzaldehyde derivatives.
The cell inactivating effect of cis-dichlorodiammineplatinum(II) in combination with 2-substituted benzaldehyde derivatives was tested using cultured human NHIK 3025 cells. Simultaneous drug combination with benzaldehyde protected cells from cis-DDP-induced cell inactivation in a dose-dependent manner. Substitution with electron-releasing groups, i.e. -CH3 and -OH, adjacent to the aldehyde moiety increased the protective effect relative to benzaldehyde. Electron-withdrawing, or bulky, substituents reduced the protective effect. Protection from cell inactivation by cis-DDP coincided with an aldehyde-mediated reduction in platinum accumulation.
Dornish
J M
JM
Department of Tissue Culture, Norwegian Radium Hospital, Oslo.
Pettersen
E O
EO
D001547:Benzaldehydes / Q000494:pharmacology*; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D002945:Cisplatin / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D006801:Humans; D010984:Platinum / Q000032:analysis; D013329:Structure-Activity Relationship
D001547:Benzaldehydes; D010984:Platinum; D002945:Cisplatin