title: Immune response of patients with congenital coagulation disorders to hepatitis B vaccine: suboptimal response and human immunodeficiency virus infection.
abstract: Seventy-eight patients with congenital coagulation disorders were treated with hepatitis B vaccine either subcutaneously or intradermally. All the children (eight vaccinated subcutaneously and eight vaccinated intradermally) responded. Seventeen of 19 (90%) anti-HIV-negative adults vaccinated subcutaneously and 14/25 (56%) anti-HIV-negative adults vaccinated intradermally showed an immune response. At 24 months, the anti-HBs level was greater than 10 IU/l in all children vaccinated subcutaneously, 83% of children vaccinated intradermally, 77% of adults vaccinated subcutaneously, and 55% of adults vaccinated intradermally. Eight of 15 (53%) adult patients who were anti-HIV positive were also anti-HBc positive before vaccination and 6/8 (75%) failed to produce an amnestic response to vaccine. Subcutaneous vaccination with regular monitoring of anti-HBs levels and appropriate boosting is recommended.
authors.affiliation: Academic Department of Haematology, Royal Free Hospital School of Medicine, London, England.
authors.forename: E J
authors.initials: EJ
authors.lastname: Miller
authors.forename: C A
authors.initials: CA
authors.lastname: Lee
authors.forename: P
authors.initials: P
authors.lastname: Karayiannis
authors.forename: S
authors.initials: S
authors.lastname: Holmes
authors.forename: H C
authors.initials: HC
authors.lastname: Thomas
authors.forename: P B
authors.initials: PB
authors.lastname: Kernoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001778:Blood Coagulation Disorders / Q000151:congenital / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004306:Dose-Response Relationship, Immunologic; D006679:HIV Seropositivity / Q000276:immunology*; D006467:Hemophilia A / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000096:biosynthesis*; D006801:Humans; D007223:Infant; D007279:Injections, Subcutaneous; D008875:Middle Aged; D011897:Random Allocation; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D006510:Hepatitis B Antibodies; D014761:Viral Hepatitis Vaccines