[Biotransformation of 5-phenyl-1,3,4-benzotriazepines].
After administration of three 2-aminosubstituted 5-phenyl-1,3,4-benzotriazepines with hypoglycemic effects to rats 10 metabolites were isolated from urine and feces besides traces of the unchanged drugs. N-Dealkylation, aromatic hydroxylation, N-acetylation and ring contraction by hydrolytic processes beginning in the stomach occurred. The main excretion route is with the feces.
Pfeifer
S
S
Sektion Chemie, Humboldt-Universität zu Berlin.
Niepel
C
C
Franke
P
P
D000818:Animals; D001552:Benzazepines / Q000493:pharmacokinetics* / Q000652:urine; D001711:Biotransformation; D005243:Feces / Q000032:analysis; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet
D001552:Benzazepines; D007004:Hypoglycemic Agents
Biotransformation von 5-Phenyl-1,3,4-benzotriazepinen.