Natural resistance in mice against Friend cells injected intravenously. III. Comparison between in vivo and in vitro passaged interferon-sensitive (745) and interferon-resistant (3Cl8) cell clones.
In vitro (FLC-Vt) or in vivo (FLC-V) passaged Friend erythroleukaemia cells of DBA/2 origin were tested for susceptibility to natural resistance (NR) in vivo or to NK cell activity in vitro. Scarcely oncogenic FLC-Vt cells were highly susceptible to in vivo NR (measured as rapid organ clearance or growth inhibition in lethally irradiated mice) or to in vitro NK attack. Conversely, highly oncogenic FLC-V cells were weakly susceptible to NR and to NK as well. These data seem to point out that natural immunity, which is up-regulated by endogenous or exogenous interferons, can play a significant role in surveillance against mouse leukaemic cells of retrovirus origin.
Neri
M
M
Department of Hygiene, University of Perugia, Italy.
Zei
T
T
Bonmassar
E
E
Rossi
G B
GB
Fiorucci
G
G
Iorio
A N
AN
D000818:Animals; D002351:Carrageenan / Q000494:pharmacology; D002460:Cell Line; D002999:Clone Cells; D003520:Cyclophosphamide / Q000494:pharmacology; D003601:Cytotoxicity Tests, Immunologic; D005622:Friend murine leukemia virus; D007113:Immunity, Innate / Q000187:drug effects; D007275:Injections, Intravenous; D007370:Interferon Type I / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology*; D051379:Mice; D008811:Mice, Inbred DBA; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000276:immunology
D007370:Interferon Type I; D003520:Cyclophosphamide; D002351:Carrageenan