[Effect of strychnine and bicuculline on responses evoked by application of inhibitory mediators in neurons of the lamprey spinal cord].
Effect of strychnine and bicuculline on responses of isolated spinal cord neurons of lamprey evoked by applications of glycine and gamma-aminobutyric acid (GABA) were investigated by means of intracellular perfusion and concentration clamp techniques. It was found that each blocker demonstrated similar effects on responses evoked by applications of both amino acids. Suggestion that glycine and GABA act on the same channel-receptor complex is put forward.
Safronov
B V
BV
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D005399:Fishes; D018756:GABA Antagonists; D005998:Glycine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007798:Lampreys; D009474:Neurons / Q000187:drug effects*; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects*; D013331:Strychnine / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D018756:GABA Antagonists; D005680:gamma-Aminobutyric Acid; D013331:Strychnine; D005998:Glycine; D001640:Bicuculline
Vliianie strikhnina i bikukullina na otvety, vyzvannye prilozheniem tormoziashchikh mediatorov, v neĭronakh spinnogo mozga minogi.