Transitory L-carnitine depletion in rat skeletal muscle by D-carnitine.
Weanling and adult rats were intraperitoneally injected with D-carnitine for 40 days. After 15 days of treatment a statistically significant depletion in the muscle levels of free and total L-carnitine was observed, but after 40 days this depletion became slight and statistically not significant. These findings suggest the presence of a compensatory mechanism acting on the inhibition of L-carnitine transport into skeletal muscle fibres.
Arancio
O
O
Istituto di Neurologia, Universitá di Verona, Policlinico Borgo Roma.
Bonadonna
G
G
Calvani
M
M
Giovene
P
P
Tomelleri
G
G
De Grandis
D
D
D000375:Aging / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D002331:Carnitine / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000033:anatomy & histology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
D002331:Carnitine