title: [An experimental study of the use of fresh aortic valve homograft for the usage of the vena caval valve. Part 1. The evaluation of hemodynamics and cineangiographic study].
abstract: The purpose of this study is to develop a vena caval valve using the fresh aortic valve homograft. A preliminary study was performed in six dogs by interposing a cryopreserved aortic valve homograft with sinus Valsalva into SVC. After making the tricuspid regurgitation, the aortic valve homograft was closed by the regurgitant flow in the systolic phase and opened by the venous return in the diastolic phase. The preliminary study showed that the cryopreserved aortic valve homograft with sinus Valsalva was useful as a vena caval valve immediately after the implantation. Fresh aortic valve homografts were implanted in 11 dogs in the same manner. Eighteen pressure studies and cine-angiographies were performed in six dogs on 8 to 165 days after the implantation. Pressure studies showed minimal/small pressure gradients across the implanted homografts. However, cineangiography revealed appearance of regurgitation through the implanted homograft three months later. Thromboembolism was not happened in all dogs at all. Therefore, we concluded that the fresh aortic homograft with sinus Valsalva might be clinically feasible for use as a vena caval valve.
authors.affiliation: Department of Pediatric Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women's Medical College.
authors.forename: K
authors.initials: K
authors.lastname: Ishihara
authors.forename: M
authors.initials: M
authors.lastname: Higashidate
authors.forename: Y
authors.initials: Y
authors.lastname: Harada
authors.forename: M
authors.initials: M
authors.lastname: Kawada
authors.forename: Y
authors.initials: Y
authors.lastname: Imai
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000637:transplantation*; D001794:Blood Pressure; D002932:Cineangiography; D004285:Dogs; D005615:Freezing; D006439:Hemodynamics; D012850:Sinus of Valsalva / Q000637:transplantation; D014021:Tissue Preservation; D014184:Transplantation, Homologous; D014262:Tricuspid Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology; D014683:Vena Cava, Superior / Q000000981:diagnostic imaging