title: An automatic syringe for coronary occlusion in long-term collateralization studies.
abstract: A portable apparatus for performing repeated, brief coronary artery occlusions automatically in long-term chronic studies involving dogs and larger animals is described. The battery-operated, back-pack-carried device uses a motorized syringe driven by a digital-programmable timing circuit to inflate a coronary artery occluder for durations of 10 s to 3 min at intervals from 14 s to 16 h. A single battery charge produces 450 occlusions. The generated pressure is adjustable to 1,000 mmHg maximum. A separate fail-safe circuit monitors system operation to open a pressure-relief valve if occlusions exceed a preset duration.
authors.affiliation: Dalton Research Center, University of Missouri, Columbia 65211.
authors.forename: W M
authors.initials: WM
authors.lastname: Caldwell
authors.forename: D P
authors.initials: DP
authors.lastname: McKown
authors.forename: J A
authors.initials: JA
authors.lastname: Bleck
authors.forename: J W
authors.initials: JW
authors.lastname: Hartley
authors.forename: T
authors.initials: T
authors.lastname: Erdal
authors.forename: E E
authors.initials: EE
authors.lastname: Barrett
authors.forename: D
authors.initials: D
authors.lastname: Franklin
mesh_terms: D000818:Animals; D003326:Coronary Circulation; D003327:Coronary Disease / Q000503:physiopathology*; D004195:Disease Models, Animal; D004285:Dogs; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods; D013594:Syringes