Oligodeoxynucleotide analogs with 5'-linked anthraquinone.
We report here the synthesis of novel 5'-linked oligodeoxynucleotides, both normal phosphodiester and phosphorothioate analogs, in which a covalently attached group at the 5'-terminus is an anthraquinone. These compounds represent a new class of antisense compounds in which the base sequence of the oligodeoxynucleotide serves to deliver a nuclease-resistant reactive drug-like molecule to a cellular target nucleic acid (mRNA or DNA).
Mori
K
K
Medicine Branch, National Cancer Institute, NIH, Bethesda, MD 20892.
Subasinghe
C
C
Cohen
J S
JS
D000880:Anthraquinones; D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D009838:Oligodeoxyribonucleotides
D000880:Anthraquinones; D009838:Oligodeoxyribonucleotides