Tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein in transgenic mice.
We investigated the tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein by introducing the C3(1) gene with 4-kilobase (kb) upstream and 2-kb downstream flanking sequences into transgenic mice. There was selective expression in the ventral prostate that was stimulated by testosterone, which indicated that the gene together with 6-kb flanking DNA contains the information required for prostate-specific and testosterone-regulated expression.
Allison
J
J
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
Zhang
Y L
YL
Parker
M G
MG
D000727:Androgen-Binding Protein / Q000235:genetics*; D000818:Animals; D015342:DNA Probes; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D011467:Prostate / Q000378:metabolism; D060789:Prostatein; D051381:Rats; D060765:Secretoglobins; D013739:Testosterone / Q000494:pharmacology; D014018:Tissue Distribution; D014598:Uteroglobin; D060788:Mammaglobin B
D000727:Androgen-Binding Protein; D015342:DNA Probes; D060789:Prostatein; D060765:Secretoglobins; D013739:Testosterone; D014598:Uteroglobin; C511484:Scgb1d2 protein, rat; C511483:Scgb1d4 protein, rat; C556468:Scgb2a1 protein, rat; D060788:Mammaglobin B