Linkage analysis with cohort effects: an application to X-linkage.
The LIPED program has been modified to incorporate cohort effects in a linkage analysis. Very significant positive lod scores are obtained between bipolar affective disorder and both the deutan and protan markers on the X-chromosome. Lod score methods are shown to be sensitive to the specification of the age of onset distributions and the parameters of the model of transmission.
Van Eerdewegh
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Department of Psychiatry, Washington University, St. Louis, MO.
D000367:Age Factors; D001714:Bipolar Disorder / Q000235:genetics*; D015331:Cohort Studies; D003198:Computer Simulation; D008040:Genetic Linkage; D006801:Humans; D014960:X Chromosome