Neurotrophic action of bombesin on ventral spinal cord in culture.
Studies with orgonotypic culture of ventral spinal cord revealed that bombesin at 10(-4) to 10(-12) M exerts a marked growth-stimulating effect. The presence of bombesin, the neuritic extension of ventral spinal cord exceeds control values 1.5-4.8 times. The growth zone of spinal cord explants increases in the bombesin treated cultures. The possible mechanism of trophic effect of bombesin on ventral cord was briefly discussed.
Iwasaki
Y
Y
Fourth Department of Internal Medicine, Toho University, Ohashi Hospital, Tokyo, Japan.
Kinoshita
M
M
Ikeda
K
K
D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003712:Dendrites / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology* / Q000187:drug effects
D001839:Bombesin