title: Protection from pentobarbital lethality mediated by Pavlovian conditioning.
abstract: The lethal effects of pentobarbital overdose were dependent upon the context in which the drug was administered. Rats received repeated injections of pentobarbital (30 mg/kg), in a distinctive environment and saline in the home room. At test, rats received a large dose (95 mg/kg) of pentobarbital. Fewer deaths occurred in a contex previously associated with drug administration. The results are consistent with a Pavlovian model of drug tolerance.
authors.affiliation: Maestria en Farmacologia Conductual, Escuela Nacional de Estudios Profesionales Iztacala.
authors.forename: J
authors.initials: J
authors.lastname: Vila
mesh_terms: D000818:Animals; D003214:Conditioning, Classical / Q000502:physiology*; D004361:Drug Tolerance; D004777:Environment; D008297:Male; D010424:Pentobarbital / Q000506:poisoning*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010424:Pentobarbital