c-Fos mRNA induction under vitamin B6 antagonist-induced seizure.
c-Fos mRNA expression was studied in mouse brain after vitamin B6 antagonist-induced seizure. The vitamin B6 antagonists used were hydrazine, thiosemicarbazide, penicillamine and deoxypyridoxine. Only deoxypyridoxine was effective in increasing c-fos mRNA and c-fos protein expression in nerve cells. The other 3 antagonists had levels of c-fos mRNA below or equal to basal level. The seizure activity induced by several vitamin B6 antagonists resulted in different effects on c-fos gene expression.
Mizuno
A
A
Department of Biochemistry, Jikei University School of Medicine, Tokyo, Japan.
Mizobuchi
T
T
Ishibashi
Y
Y
Matsuda
M
M
D000818:Animals; D015152:Blotting, Northern; D001921:Brain / Q000378:metabolism*; D006834:Hydrazines / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010396:Penicillamine / Q000494:pharmacology; D011519:Proto-Oncogenes; D011736:Pyridoxine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis*; D012640:Seizures / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism*; D012663:Semicarbazides / Q000494:pharmacology
D006834:Hydrazines; D012333:RNA, Messenger; D012663:Semicarbazides; C029424:hydrazine; C005151:thiosemicarbazide; D010396:Penicillamine; D011736:Pyridoxine