Synthesis, characterization, and biodistribution of [113mIn]TE-BAT: a new myocardial imaging agent.
In order to develop a new myocardial perfusion agent, new lipid-soluble complexes containing a net charge of +1 were evaluated. Synthesis, radiolabeling, characterization, and biodistribution of a unique indium complex, [113mIn]TE-BAT (tetraethyl-bis-aminoethanethiol), are described. The complex formation between In +3 and TE-BAT ligand is rapid, simple, and of high yield (greater than or equal to 95%). This process is amenable to kit formulation. The complex has a net charge of +1 and an In/ligand ratio of 1:1. Biodistribution in mice shows higher heart uptake and longer retention as compared to 201TI. This complex, when labeled with 111In, shows promise as a possible tracer for myocardial perfusion imaging.
Liu
B L
BL
Department of Chemistry, Beijing Normal University, China.
Kung
H F
HF
Jin
Y T
YT
Zhu
L
L
Meng
M
M
D000818:Animals; D003543:Cysteamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D006321:Heart / Q000000981:diagnostic imaging*; D007205:Indium Radioisotopes; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D051379:Mice; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D007205:Indium Radioisotopes; C060158:tetraethyl-bis(aminoethanethiol); D003543:Cysteamine