Effects of atropine and azaprophen on matching and detection in rhesus monkeys.
The effects of the anticholinergic atropine and azaprophen, a novel, conformationally restricted analog of atropine, were examined in rhesus monkeys using delayed match-to-sample and detection tasks. Both compounds (0.01-0.32 mg/kg) produced dose-dependent decreases in the rate of responding under both tasks. Drug effects on the match-to-sample task correlated with drug effects on the detection task. Both compounds produced decreases in the percentage of correct responses on the match-to-sample task when choice trials occurred 4 or 16 sec, but not 0.01 sec, following sample presentation. Doses of atropine and azaprophen decreasing accuracy on the match-to-sample task also decreased the number of responses on the task. In general, atropine was slightly more potent than azaprophen on both tasks. These results further characterize azaprophen's anticholinergic effects.
Genovese
R F
RF
Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
Elsmore
T F
TF
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D008253:Macaca mulatta; D008297:Male; D008568:Memory / Q000187:drug effects; D010666:Phenylpropionates / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects*; D014326:Tropanes / Q000494:pharmacology*
D010666:Phenylpropionates; D014326:Tropanes; C052339:azaprophen; D001285:Atropine