[The role of the neurons of the locus coeruleus and ventral tegmental area in the development of catecholamine-deficient conditions].
Selective neurotoxic effect of 6-hydroxydopamine on the catecholaminergic systems was used to study the structural changes in the locus coeruleus and ventral tegmental neurons. Compared with the earlier published data on the blood-brain barrier permeability, the peculiarities of the responses of a part of neurons and synapses of the sites under study suggest that this selective catecholaminergic systems lesion leads to a decrease in their influence on the brain structures innervated. This causes impairment of inter-neurotransmitter relations and provide a morphological basis of various functional CNS shifts.
Kucherenko
R P
RP
Gilerovich
E G
EG
Otellin
V A
VA
D000818:Animals; D004298:Dopamine / Q000172:deficiency*; D008125:Locus Coeruleus / Q000378:metabolism*; D009638:Norepinephrine / Q000172:deficiency*; D010300:Parkinson Disease / Q000209:etiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000378:metabolism; D013681:Tegmentum Mesencephali / Q000378:metabolism*
D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D004298:Dopamine; D009638:Norepinephrine
Uchastie neĭronov golubogo piatna i ventral'noĭ tegmental'noĭ oblasti v razvitii katekholamindefitsitnykh sostoianii.