DNA damage in liver and kidney of rats after treatment with hydralazine in vivo.
Alkaline elution has been used to examine the integrity of DNA isolated from liver and kidney from rats treated with hydralazine (1-hydrazinophthalazine). Hydralazine was administered intragastrically at daily doses of 5, 10 and 25 mg per kg body weight to randomly bred female Wistar rats during 3 weeks. The relative strand scission, expressed as rad equivalents increased with increasing drug dose. The incidence of strand scission gives further support to the suggestion that hydralazine can be metabolically activated generating DNA-reactive species.
Jendryczko
A
A
Department of Biochemistry and Chemistry, Silesian Medical School, Katowice, Poland.
Drozdz
M
M
D000818:Animals; D004247:DNA / Q000187:drug effects / Q000302:isolation & purification; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D005260:Female; D006830:Hydralazine / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D006830:Hydralazine; D004247:DNA