title: Intraoral grafting of a canine full-thickness oral mucosal equivalent produced in vitro.
abstract: A canine full-thickness oral mucosal equivalent (FTOME) was produced in vitro and used in intraoral grafting. The FTOME consisted of an autologous stratified epithelial surface layer overlying an acellular bilaminar collagenous matrix. The material was grafted on the periosteum of deepithelialized edentulous alveolar ridges in dogs. Biopsies of the grafted FTOME showed that the epithelium remained viable, migrated over the surrounding tissue, and aided in wound healing.
authors.affiliation: Ohio State University, College of Dentistry, Department of Oral and Maxillofacial Surgery, Columbus 43210.
authors.forename: S E
authors.initials: SE
authors.lastname: Feinberg
authors.forename: V
authors.initials: V
authors.lastname: Krishnan
authors.forename: G
authors.initials: G
authors.lastname: Gordillo
authors.forename: C F
authors.initials: CF
authors.lastname: Shuler
mesh_terms: D000539:Alveolar Process / Q000473:pathology / Q000601:surgery*; D000818:Animals; D003094:Collagen; D046508:Culture Techniques / Q000379:methods; D004285:Dogs; D008334:Mandible; D009061:Mouth Mucosa / Q000473:pathology / Q000601:surgery / Q000637:transplantation*
chemical_list: D003094:Collagen