Recovery kinetics deduced from continuous low dose-rate experiments.
Information on the rate of recovery from potentially lethal damage can be obtained from the analysis of the radiation dose-rate effect. Two mathematical models are useful in this respect: the Lethal-Potentially. Lethal (LPL) model of Curtis and the Incomplete Repair (IR) model of Thames. Full cell-survival curves are required at three or more dose rates in order to make a reliable analysis. Studies on human tumour cell lines yield values for recovery half-time in the range 0.1 to 0.9 h, and for each cell line the half-time found in this way is shorter than that obtained from a split-dose experiment. This result may imply that cellular recovery is a multi-component or a saturable process.
Steel
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Department of Radiotherapy Research, Institute of Cancer Research, Sutton, Surrey, U.K.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D004260:DNA Repair / Q000528:radiation effects*; D004273:DNA, Neoplasm / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D066298:In Vitro Techniques; D008962:Models, Theoretical; D011836:Radiation Tolerance; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000528:radiation effects*
D004273:DNA, Neoplasm