title: [Prostatic tissue and fluid levels of lomefloxacin (NY-198)].
abstract: The concentration of Lomefloxacin (NY-198), a new quinolone, in human prostatic tissue and fluid was examined. Lomefloxacin was concentrated in prostatic gland and the mean ratios of prostatic tissue levels to serum levels (P/S) were 1.39-1.83 during 2 to 6 hrs after administration. Concerning prostatic fluid concentrations, there were no significant differences between healthy volunteers and patients with chronic prostatitis. The mean ratios of prostatic fluid levels to serum levels (Pf/S) were 0.36-0.77 during 1 to 4 hrs after administration. The concentration of Lomefloxacin in the prostatic tissue and fluid is high enough to eradicate the majority of pathogens causing bacterial prostatitis.
authors.affiliation: Department of Urology, Okayama University, Medical School.
authors.forename: Y
authors.initials: Y
authors.lastname: Nasu
authors.forename: Y
authors.initials: Y
authors.lastname: Nishitani
authors.forename: D
authors.initials: D
authors.lastname: Yamada
authors.forename: S
authors.initials: S
authors.lastname: Hayata
authors.forename: M
authors.initials: M
authors.lastname: Tsugawa
authors.forename: M
authors.initials: M
authors.lastname: Kishi
authors.forename: A
authors.initials: A
authors.lastname: Mizuno
authors.forename: H
authors.initials: H
authors.lastname: Kumon
authors.forename: H
authors.initials: H
authors.lastname: Ohmori
authors.forename: K
authors.initials: K
authors.lastname: Nanba
mesh_terms: D042462:4-Quinolones; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001826:Body Fluids / Q000378:metabolism*; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism*; D011472:Prostatitis / Q000378:metabolism; D015363:Quinolones; D013997:Time Factors
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin