title: Dorsal-ventral gradient in vulnerability of CA1 hippocampus to ischemia: a combined histological and electrophysiological study.
abstract: Transverse hippocampal slices were prepared after 7 days survival from rats subjected to 8 min of global incomplete ischemia by temporary occlusion of both carotid arteries and hypotension. The slices demonstrated a dorsal-ventral gradient in the amount of ischemic neuronal necrosis in the CA1 region. Histologically ischemic cell change decreased from 90% dorsoseptally to 10% ventrotemporally. Electrophysiological analysis of the number of slices with viable synaptic transmission in CA1 also revealed a septotemporal gradient in susceptibility to ischemia.
authors.affiliation: Department of Neuropsychopharmacology, Janssen Research Foundation, Beerse, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Ashton
authors.forename: J
authors.initials: J
authors.lastname: Van Reempts
authors.forename: M
authors.initials: M
authors.lastname: Haseldonckx
authors.forename: R
authors.initials: R
authors.lastname: Willems
mesh_terms: D000200:Action Potentials; D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology; D066298:In Vitro Techniques; D002546:Ischemic Attack, Transient / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains