The behavioral effects of pesticides in male mice.
Male Swiss mice, 25-30 g, were utilized to define some of the behavioral effects of the herbicides Lasso [alachlor 43%; (A)], Basalin [fluchloralin 45%; (F)], Premerge 3 [dinoseb 51%; (D)], and the fungicide Maneb-80 [maneb 80%; (M)]. These compounds were tested for their effects on locomotor activity and for their ability to establish a conditioned taste aversion following oral or dermal exposure. Individual and grouped (N = 5) activity measures were assessed immediately following the dermal administration of the commercially available pesticide formulations. Grouped activity measures were also assessed following the oral administration of the compounds. Total activity was significantly (p less than 0.05) increased over vehicle controls in both grouped and individual subjects by A, F, and D following dermal administration. Grouped activity measures were also increased by A, F, D, and M following the oral administration of the compounds. Similar subjects were tested in a conditioned taste aversion paradigm using a normally preferred 0.3% saccharin solution. Animals were given 30 min access to the saccharin solution followed immediately by the administration of the pesticide or control solution. Twenty-four hours later, animals were given the choice of 2 solutions, one containing water and the other the 0.3% saccharin solution. The percent saccharin consumed and the total fluid intake were calculated for each group (N = 8/group). A, F, and D produced a significant aversion to (N = 8/group) the saccharin following both oral and dermal administration. Oral administration of M, but not dermal exposure, also resulted in a flavor aversion. Total fluid intake, however, was not altered by any of the treatments.(ABSTRACT TRUNCATED AT 250 WORDS)
Mitchell
J A
JA
Department of Pharmacology, School of Pharmacy, University of Mississippi, University 38677.
Long
S F
SF
Wilson
M C
MC
Kallman
M J
MJ
D019297:2,4-Dinitrophenol / Q000031:analogs & derivatives*; D000081:Acetamides / Q000008:administration & dosage / Q000633:toxicity*; D000279:Administration, Cutaneous; D000284:Administration, Oral; D000814:Aniline Compounds / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D004140:Dinitrophenols / Q000008:administration & dosage / Q000633:toxicity*; D006540:Herbicides / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D008344:Maneb / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D013859:Thiocarbamates / Q000633:toxicity*
D000081:Acetamides; D000814:Aniline Compounds; D004140:Dinitrophenols; D006540:Herbicides; D013859:Thiocarbamates; D008344:Maneb; C000188:alachlor; C012322:fluchloralin; D019297:2,4-Dinitrophenol; C018527:dinoseb