title: Ganoderic acid and its derivatives as cholesterol synthesis inhibitors.
abstract: Oxygenated lanosterol derivatives, which were isolated from Ganoderma lucidum (Polyporaceae) or their derivatives obtained by chemical conversion, were tested for their effect on cholesterol biosynthesis from 24,25-dihydrolanosterol by rat hepatic subcellular 10,000 x g supernatant fraction. The sterol (VI, 40 microM) with 7-oxo and 15 alpha-hydroxy groups potently inhibited the synthesis of cholesterol from [24,25-3H]-24,25-dihydrolanosterol (18 microM).
authors.forename: Y
authors.initials: Y
authors.lastname: Komoda
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: Y
authors.initials: Y
authors.lastname: Sonoda
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000096:biosynthesis*; D066298:In Vitro Techniques; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011124:Polyporaceae / Q000378:metabolism; D051381:Rats
chemical_list: D000924:Anticholesteremic Agents; D007810:Lanosterol; D002784:Cholesterol