Life-threatening intracranial bleeding associated with the presence of an antifactor VII autoantibody.
This is a report of a 62-year-old male patient who had a bleeding disorder due to the presence of a factor VII (proconvertin) inhibitor. After treatment with a high-dose intravenous (IV) immunoglobulin failed and a life-threatening intracranial hemorrhage occurred, plasma exchanges were performed and immunosuppressive therapy was given. The factor VII inhibitor promptly disappeared, and the patient's parameters of hemostasis became normal. Even though a relapse occurred some months later, the patient responded to immunosuppressive therapy. No underlying disorder was evidenced after 17 months of follow-up.
Delmer
A
A
Service d'Hématologie, Laboratoire Central d'Hématologie, Hôtel-Dieu, Paris, France.
Horellou
M H
MH
Andreu
G
G
Lecompte
T
T
Rossi
F
F
Kazatchkine
M D
MD
Samama
M
M
Zittoun
R
R
D001327:Autoimmune Diseases / Q000097:blood*; D001778:Blood Coagulation Disorders / Q000276:immunology*; D002543:Cerebral Hemorrhage / Q000097:blood / Q000276:immunology*; D005167:Factor VII / Q000037:antagonists & inhibitors / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time
D005167:Factor VII