title: Reproductive traits, lactation and foal growth in mares fed altrenogest.
abstract: Lactating mares were assigned as controls or fed altrenogest (.044 mg.kg body wt-1.d-1) for 15 d after foaling. Mares (n = 6) fed altrenogest were inseminated during the first estrus after treatment and mares (n = 6) in the control group were inseminated during the second postpartum estrus. Ovulation during the estrus in which mares were inseminated occurred 26 +/- 1 d postpartum for treated mares and 36 +/- 1 d postpartum for control mares. The percentage of mares conceiving was not different for control (67%) and alternogest-treated (100%) mares. No differences were observed in tone and size of the uterus or size of the ovulatory follicle between treated and control groups. Uterine cultures and biopsies collected on d 7 and 15 postpartum were similar between treatment and control groups in bacterial populations or endometrial epithelial cell height. Blood was collected on d 7, 11, 15, 19 and 23 postpartum, and concentrations of estradiol-17 beta in serum were determined by radioimmunoassay. Mean concentrations of estradiol-17 beta across days were 10 +/- .8 and 12 +/- .6 pg/ml for control and treated mares, respectively. Concentrations of serum estradiol-17 beta were higher (P less than .05) in treated mares on d 23 postpartum. Daily milk yields, determined by the weigh-suckle-weigh method, and milk composition were similar between treatment groups on each collection day. Altrenogest can be used to predictably delay estrus in the postpartum mare without altering fertility, yield and composition of milk, or foal growth.
authors.affiliation: Dept. of Anim. Sci. and Industry, Kansas State University, Manhattan 66506.
authors.forename: D H
authors.initials: DH
authors.lastname: Sigler
authors.forename: D E
authors.initials: DE
authors.lastname: Ericson
authors.forename: P G
authors.initials: PG
authors.lastname: Gibbs
authors.forename: G H
authors.initials: GH
authors.lastname: Kiracofe
authors.forename: J S
authors.initials: JS
authors.lastname: Stevenson
mesh_terms: D000818:Animals; D004717:Endometrium / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D004958:Estradiol / Q000097:blood; D004963:Estrenes / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006736:Horses / Q000254:growth & development / Q000502:physiology*; D007774:Lactation / Q000187:drug effects*; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D045167:Progesterone Congeners / Q000494:pharmacology*; D011897:Random Allocation; D014204:Trenbolone Acetate / Q000031:analogs & derivatives / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects
chemical_list: D004963:Estrenes; D045167:Progesterone Congeners; C023445:altrenogest; D004958:Estradiol; D014204:Trenbolone Acetate