[Protein conformation and localization in low density lipoproteins in health and in ischemic heart disease].
The study has shown that the ratio of elements in the secondary structure of LDL protein from patients with the coronary heart disease from health subjects is similar. However LDL protein is displaced by 0.5 nm towards the water phase in patients with CHD comparing with healthy subjects. It is likely that such differences are a result of the lower stability of LDL protein in CHD. It is supposed that the damage of lipoprotein particles (premodification) in CHD becomes atherogenic in the vessel wall after the action of additional factors.
Kuznetsov
A S
AS
Parfenova
N S
NS
Sungurov
A Iu
AIu
Olennikova
L V
LV
Omel'ianenko
V G
VG
D002942:Circular Dichroism; D003327:Coronary Disease / Q000378:metabolism*; D005453:Fluorescence; D006801:Humans; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D011487:Protein Conformation
D008055:Lipids; D008077:Lipoproteins, LDL
Konformatsiia i lokalizatsiia belka v lipoproteinakh nizkoĭ plotnosti v norme i pri ishemicheskoĭ bolezni serdtsa.