The effect of dietary alpha-bromopalmitate on blood lipids in the rat.
When alpha-bromopalmitate was fed to rats for 9-30 days, the level of serum triacylglycerol increased up to 2-fold over the concentration of controls. alpha-Bromopalmitate treatment had no effect on concentration of complex lipids in liver, while the triacylglycerol level in heart was significantly enhanced. From metabolic studies using isolated hepatocytes and liver microsomes, it is suggested that the increased serum triacylglycerol level after alpha-bromopalmitate feeding is mainly due to reduced fatty acid oxidation in both liver and peripheral tissues, and to a lesser extent, to inhibited fatty acid uptake and esterification.
Hagve
T A
TA
Institute of Clinical Biochemistry, University of Oslo, Rikshospitalet, Norway.
Narce
M
M
Grønn
M
M
Christensen
E
E
Ulmann
L
L
Poisson
J P
JP
Christophersen
B
B
D000818:Animals; D004951:Esterification; D005227:Fatty Acids / Q000378:metabolism; D066298:In Vitro Techniques; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010168:Palmitates / Q000494:pharmacology*; D010169:Palmitic Acids / Q000494:pharmacology*; D051381:Rats
D005227:Fatty Acids; D008055:Lipids; D010168:Palmitates; D010169:Palmitic Acids; C022776:2-bromopalmitate