title: Trials of adjunctive alprazolam in "negative symptom" patients.
abstract: Four case reports are described in which adjunctive alprazolam was administered to schizophrenic or schizoaffective patients who satisfied criteria for the syndrome of "negative symptoms". The addition of alprazolam to ongoing neuroleptic and antiparkinsonian drug treatment produced substantial clinical benefit in only one of these cases, and that benefit was not replicated in a second trial in this case. These results are discussed in comparison to previously reported findings in other alprazolam-treated "negative symptom" patients.
authors.affiliation: Mount Sinai Medical Center, New York, N.Y.
authors.forename: F
authors.initials: F
authors.lastname: Adan
authors.forename: S G
authors.initials: SG
authors.lastname: Siris
mesh_terms: D000328:Adult; D000525:Alprazolam / Q000008:administration & dosage*; D003866:Depressive Disorder / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005476:Fluphenazine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006212:Hallucinations / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000188:drug therapy*; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
chemical_list: C011825:fluphenazine depot; D005476:Fluphenazine; D000525:Alprazolam