title: [Stimulating effect of biologically active substances from the spleen on the functional activity of hepatocytes].
abstract: Studies in the effect of both splenin and spleen "protein-free extract" on the monolayer culture of chick hepatic embryos have revealed that small doses exert a stimulating effect on hepatocytes, while the large ones induce degenerative changes. Hepatotrophic characters of the "protein-free extract" are determined, while utilizing lower doses than those of splenin.
authors.forename: V V
authors.initials: VV
authors.lastname: Korpachev
authors.forename: D S
authors.initials: DS
authors.lastname: Onishchenko
mesh_terms: D000818:Animals; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology* / Q000187:drug effects; D008934:Mitogens; D008938:Mitosis / Q000187:drug effects*; D013946:Thymopoietins / Q000008:administration & dosage / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*; D014020:Tissue Extracts / Q000494:pharmacology*
chemical_list: D008934:Mitogens; D013946:Thymopoietins; D013951:Thymus Hormones; D014020:Tissue Extracts; C032841:thymopoietin III
vernacular_title: Stimuliruiushchiĭ éffekt biologicheski aktivnykh veshchestv selezenki na funktsional'nuiu aktivnost' gepatotsitov.