[Effect of verapamil on the functional status of thrombocytes in patients with ischemic heart disease].
A study of 20 anginal patients demonstrated signs of platelet hyperreactivity: increased platelet aggregation, increased mobilization of Ca2+ from platelet membranes, and increased production of malonic dialdehyde. A short-term treatment with isoptin-120 (360 mg daily) produced a considerable drop in those parameters. It is suggested that the drug's basic effect is due to the inhibition of intracellular calcium redistribution in the platelets of coronary patients.
Belousov
Iu B
IuB
Azizova
O A
OA
Razumov
V B
VB
Gutkin
A B
AB
Borin
M L
ML
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors; D014700:Verapamil / Q000627:therapeutic use*
D010975:Platelet Aggregation Inhibitors; D008315:Malondialdehyde; D014700:Verapamil
Vliianie verapamila na funktsional'noe sostoianie trombotsitov u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.