Insulin-like growth factor I (IGF-I) stimulates regeneration of the rat sciatic nerve.
The effect of insulin-like growth factor I (IGF-I) was tested on regeneration of the rat sciatic nerve after a crush lesion. IGF-I was administered via miniosmotic pumps to the dorsal root ganglia or locally around the crush lesion. Regeneration of sensory fibers was measured after 3 or 4 days superfusion by pinching. IGF-I stimulated regeneration in both administration paradigms. Regeneration was inhibited if the nerve was perfused with specific antibodies to native IGF-I. The results suggest that endogenous extracellular IGF-I plays an important role during regeneration of peripheral nerve fibers.
Kanje
M
M
Department of Zoophysiology, University of Lund, Sweden.
Skottner
A
A
Sjöberg
J
J
Lundborg
G
G
D000818:Animals; D007106:Immune Sera / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000276:immunology / Q000494:pharmacology*; D009416:Nerve Regeneration / Q000187:drug effects*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology*; D013002:Somatomedins / Q000494:pharmacology*
D007106:Immune Sera; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I