title: A radiosynthesis of fluorine-18 fluoromisonidazole.
abstract: A new preparation of [18F]fluoromisonidazole [1H-1-(3-[18F] fluoro-2-hydroxypropyl)-2-nitroimidazole] is presented as a two-step, two-pot reaction sequence. The method is useful for the production of 20-30 mCi quantities of this compound from [18F]fluoride, available in 40% radiochemical yield at end of bombardment (EOB) with a specific activity (nca) of greater than 650 Ci/mmol (EOB) and a synthesis time of approximately 140 min. The key feature of the reaction scheme is the preparation of a new fluoroalkylating agent, [18F]epifluorohydrin.
authors.affiliation: Department of Radiology, University of Washington, Seattle 98195.
authors.forename: J R
authors.initials: JR
authors.lastname: Grierson
authors.forename: J M
authors.initials: JM
authors.lastname: Link
authors.forename: C A
authors.initials: CA
authors.lastname: Mathis
authors.forename: J S
authors.initials: JS
authors.lastname: Rasey
authors.forename: K A
authors.initials: KA
authors.lastname: Krohn
mesh_terms: D005462:Fluorine Radioisotopes; D007553:Isotope Labeling / Q000379:methods; D008920:Misonidazole / Q000031:analogs & derivatives* / Q000138:chemical synthesis
chemical_list: D005462:Fluorine Radioisotopes; D008920:Misonidazole