Experimental evaluation of a gelatin-coated polyester graft used as an arterial substitute.
Protein coating and endothelial cell preseeding have been proposed and studied as improvements to arterial prostheses. In this paper, an impervious polyester vascular graft which had been coated with cross-linked gelatin was compared to a porous one over a period of up to 8 months in dogs. This evaluation involved in vivo methods using radio tracers to study patency and thrombogenicity and in vitro controls of the healing processes. The main advantages offered by coated grafts over uncoated include the absence of preclotting and better biointegration.
Bordenave
L
L
CEEMASI, Inserm U.306, Université de Bordeaux II, France.
Caix
J
J
Basse-Cathalinat
B
B
Baquey
C
C
Midy
D
D
Baste
J C
JC
Constans
H
H
D000818:Animals; D001158:Arteries / Q000601:surgery*; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D004285:Dogs; D005260:Female; D005263:Femoral Artery / Q000473:pathology / Q000601:surgery; D005780:Gelatin; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011091:Polyesters; D013499:Surface Properties; D014654:Vascular Patency
D001672:Biocompatible Materials; D011091:Polyesters; D005780:Gelatin