title: [An unusual mechanism of lead poisoning. Presentation of a case].
abstract: A case is described, that came to our attention for suspected acute intermittent porphyria, with abdominal pain and ascending tetraplegia. The patient (HIV positive and with a HBsAg positive chronic aggressive hepatitis) was a heroin addict. In urine: high porphyrins with extremely increased delta amino-levulinic acid (ALA) and normal porphobilinogen. High protoporphyrin was present in blood red cells. The lead poisoning was confirmed by a very low ALA-dehydratase activity in erythrocytes and a high content of lead in urine and plasma. With Ca-versenate and penicillamine the abdominal and neurological symptoms rapidly disappeared. The possibility of contact with lead, professional or environmental, was ruled out. It was found however, that shortly before the appearance of symptoms, the patient had used a batch of unrefined brown sugar heroin, which was probably mixed with lead salts. It is noteworthy that during the same period, other young heroin addicts died with similar symptoms.
authors.forename: L
authors.initials: L
authors.lastname: D'Alessandro Gandolfo
authors.forename: A
authors.initials: A
authors.lastname: Macrì
authors.forename: G
authors.initials: G
authors.lastname: Biolcati
authors.forename: F
authors.initials: F
authors.lastname: Rossi
authors.forename: A
authors.initials: A
authors.lastname: Cirelli
authors.forename: A
authors.initials: A
authors.lastname: Barlattani
authors.forename: G C
authors.initials: GC
authors.lastname: Topi
mesh_terms: D000328:Adult; D000622:Aminolevulinic Acid / Q000652:urine; D006556:Heroin Dependence / Q000150:complications*; D006801:Humans; D007854:Lead / Q000097:blood / Q000652:urine; D007855:Lead Poisoning / Q000097:blood / Q000201:enzymology / Q000209:etiology* / Q000652:urine; D008297:Male; D000623:Porphobilinogen Synthase / Q000097:blood
chemical_list: D007854:Lead; D000622:Aminolevulinic Acid; D000623:Porphobilinogen Synthase
vernacular_title: Inconsueta modalità d'intossicazione da piombo. Presentazione di un caso.