Cytophotometric investigations on a chronic tubular nephropathy simulating preneoplastic condition.
Cytophotometric investigations were performed on the atypical renal tubular epithelium of a young man who died of renal failure, possibly due to chronic lead exposure. The aim of this analysis was to determine whether nuclear atypia indicates incipient malignancy or is a type of so-called "benign atypias". DNA histogram, showing euploid polyploidy supports the latter view and the dysplastic epithelial lesion is not even considered to be a preneoplastic condition.
Károlyi
P
P
Department of Pathology, County Hospital Szolnok, Pécs, Hungary.
Hegedüs
G
G
Szentirmay
Z
Z
Deák
G
G
D000328:Adult; D003592:Cytophotometry; D004247:DNA / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007680:Kidney Neoplasms / Q000473:pathology*; D007684:Kidney Tubules / Q000473:pathology*; D007854:Lead / Q000032:analysis; D007855:Lead Poisoning / Q000473:pathology*; D008168:Lung / Q000473:pathology; D008297:Male; D009784:Occupational Diseases / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology*
D007854:Lead; D004247:DNA