title: Chromosomal alterations and DNA content in rats during ageing.
abstract: Chromosome analysis of bone marrow cells from 96 sex-matched Rattus norvegicus of 12 different age groups showed a significant increase in hypodiploid cells with ageing. However, in meiotic preparations from gonadal cells of male rats the frequency of hypodiploid or hyperdiploid cells did not change significantly. In situ DNA estimation of bone marrow nuclei, following Feulgen cytophotometry, also did not show any significant difference with gradual age changes.
authors.affiliation: Department of Botany, University of Calcutta, India.
authors.forename: S
authors.initials: S
authors.lastname: Sen
authors.forename: G
authors.initials: G
authors.lastname: Talukder
authors.forename: A
authors.initials: A
authors.lastname: Sharma
mesh_terms: D000375:Aging / Q000235:genetics*; D000782:Aneuploidy; D000818:Animals; D001854:Bone Marrow Cells; D002455:Cell Division; D002875:Chromosomes / Q000032:analysis*; D004247:DNA / Q000032:analysis*; D004171:Diploidy; D005260:Female; D008297:Male; D008540:Meiosis; D008677:Metaphase; D008940:Mitotic Index; D011123:Polyploidy; D011418:Prophase; D051381:Rats; D013737:Testis / Q000166:cytology
chemical_list: D004247:DNA