title: Comparative effects of roxithromycin and erythromycin on cellular immune functions in vitro. 3. Killing of intracellular Staphylococcus aureus by human macrophages.
abstract: The in vitro effect of roxithromycin on the bactericidal activity of human macrophages was compared with that of erythromycin. At a concentration of half the MIC roxithromycin showed a much more impressive killing capacity on macrophage-ingested live Staphylococcus aureus than did erythromycin, under all the experimental conditions used.
authors.affiliation: Institute of Microbiology, University of Turin, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Cuffini
authors.forename: N A
authors.initials: NA
authors.lastname: Carlone
authors.forename: V
authors.initials: V
authors.lastname: Tullio
authors.forename: M
authors.initials: M
authors.lastname: Borsotto
mesh_terms: D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007933:Leucomycins / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology*
chemical_list: D007933:Leucomycins; D004917:Erythromycin