title: [Method of intrapulmonary therapy of lung diseases using needle jet injector].
abstract: A procedure for intrapulmonary endolymphatic therapy is described. Transthoracic intrapulmonary administration of antibiotics was performed with a needle jet injector (NJI-1). Pharmacokinetics of penicillin after its transthoracic intrapulmonary administration to patients was studied. Investigation of elimination of the antibiotics after their administration with NJI-1 showed that the main part of the antibiotics (up to 70 per cent) accumulated in the endolymphatic system of the lungs. Favourable clinical effects of the antibiotic needle jet injection were observed in the patients with acute nonspecific pulmonary diseases: decreased hospitalization terms and lower total course doses of the antibiotics.
authors.forename: V M
authors.initials: VM
authors.lastname: Provotorov
authors.forename: L P
authors.initials: LP
authors.lastname: Galkina
authors.forename: V V
authors.initials: VV
authors.lastname: Provotorov
authors.forename: P E
authors.initials: PE
authors.lastname: Chesnokov
mesh_terms: D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004285:Dogs; D005069:Evaluation Studies as Topic; D006801:Humans; D007273:Injections, Intramuscular; D007277:Injections, Jet; D008168:Lung; D008169:Lung Abscess / Q000188:drug therapy; D008171:Lung Diseases / Q000188:drug therapy*; D008297:Male; D010406:Penicillins / Q000008:administration & dosage / Q000493:pharmacokinetics; D011014:Pneumonia / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins
vernacular_title: Metod intrapul'monal'noĭ terapii zabolevanii legkikh s primeneniem igol'no-struĭnogo inëktora.