title: [The role of sarcolemma calcium pump in regulating tonic smooth muscle contraction].
abstract: Vanadate (10(-4)-10(-3) M) effectively blocks Mg2+, ATP-dependent Ca2+ transport in sarcolemmal vesicles and induces a slowly tonic contraction of the smooth muscle. This contraction was observed both with and without nifedipine (10(-5) M) evoking complete inhibition of hyperpotassium contracture, the Ca2+ removal from the solution washing the muscular preparation stimulating the tone decrease. There is a close correlation between the dose-dependent effects of vanadate on the Ca pump activity and tension. It is concluded that in smooth muscles, at least in myometrium, the sarcolemmal Ca-pump is involved into the control of the tonic tension.
authors.forename: S A
authors.initials: SA
authors.lastname: Kosterin
authors.forename: F V
authors.initials: FV
authors.lastname: Burdyga
authors.forename: I V
authors.initials: IV
authors.lastname: Chervonenko
authors.forename: N F
authors.initials: NF
authors.lastname: Burchinskaia
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D002417:Cattle; D005260:Female; D008274:Magnesium / Q000037:antagonists & inhibitors; D009130:Muscle, Smooth / Q000378:metabolism*; D009215:Myometrium / Q000378:metabolism; D011817:Rabbits; D012508:Sarcolemma / Q000187:drug effects / Q000378:metabolism*; D014638:Vanadates / Q000494:pharmacology
chemical_list: D014638:Vanadates; D000255:Adenosine Triphosphate; D008274:Magnesium; D002118:Calcium
vernacular_title: Rol' kal'tsievogo nasosa sarkolemmy v reguliatsii tonicheskogo sokrashcheniia gladkoĭ myshtsy.