title: Improvement in spasmodic torticollis following treatment and withdrawal from high dose lorazepam--clinical observations.
abstract: 1. Six consecutive patients with idiopathic spasmodic torticollis (ST) in whom initial amelioration with lorazepam was lost, improved following withdrawal from high doses of lorazepam (3 entered remission or virtual remission; 3 showed marked to moderate improvement). None of 12 control patients improved. 2. The possibility that benzodiazepine-receptor mechanisms play a role in the pathophysiology of ST is proposed to explain these findings.
authors.affiliation: Department of Psychiatry, Montreal General Hospital, Research Centre, P.Q.
authors.forename: S
authors.initials: S
authors.lastname: Lal
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D014103:Torticollis / Q000188:drug therapy*
chemical_list: D008140:Lorazepam