title: Absence of genetic linkage of Charcot-Marie-Tooth disease (HMSN Ia) with chromosome 1 gene markers.
abstract: We previously reported a large Charcot-Marie-Tooth family not linked to the Duffy blood group marker, supporting the existence of genetic heterogeneity in this neuropathy. In order to investigate the possibility of another disease locus on chromosome 1, we analyzed this family further, using DNA polymorphisms of 6 genes. Absence of linkage makes a second disease locus on chromosome 1 unlikely.
authors.affiliation: Department of Biochemistry, University of Antwerp, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Raeymaekers
authors.forename: P
authors.initials: P
authors.lastname: De Jonghe
authors.forename: H
authors.initials: H
authors.lastname: Backhovens
authors.forename: A
authors.initials: A
authors.lastname: Wehnert
authors.forename: G
authors.initials: G
authors.lastname: De Winter
authors.forename: L
authors.initials: L
authors.lastname: Swerts
authors.forename: J
authors.initials: J
authors.lastname: Gheuens
authors.forename: J J
authors.initials: JJ
authors.lastname: Martin
authors.forename: A
authors.initials: A
authors.lastname: Vandenberghe
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
mesh_terms: D002607:Charcot-Marie-Tooth Disease / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000502:physiology*; D004247:DNA; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D009134:Muscular Atrophy, Spinal / Q000235:genetics*; D011110:Polymorphism, Genetic; D012984:Software
chemical_list: D005819:Genetic Markers; D004247:DNA