[Dopaminergic control of aldosterone and prolactin secretion during normal pregnancy and toxemia of pregnancy].
To investigate the dopaminergic regulation of plasma aldosterone and prolactin secretion during the third trimester of pregnancy, the following experiments were performed. All patients gave informed consent before entering the study. Fourteen non-pregnant women, 22 normal pregnant women and 9 patients with severe toxemia of pregnancy (Gestosis Index; 4-6) during the 32nd-41st weeks of gestation, and 8 puerperal women were received 10mg of metoclopramide (MCP) i.v. as a bolus. Plasma aldosterone concentrations were measured sequentially according to time course. The aldosterone levels in maternal vein and umbilical cord vessels at delivery in 10 term-pregnant women were compared. In addition, changes in plasma aldosterone, estradiol, progesterone and hCG levels after placental delivery were observed in 5 normal pregnant women. Plasma aldosterone concentrations increased gradually throughout normal pregnancy, and peak values in the third trimester were approximately seven times as great as those in the non-pregnant state. The aldosterone responses (net increase) to MCP in normal pregnancy were markedly greater than those in the other three groups. Plasma basal aldosterone levels and their responses to MCP in toxemia of pregnancy were significantly lower than in normal pregnancy. Plasma basal prolactin levels and their responses to MCP during pregnancy and puerperium were significantly greater than those in non-pregnancy. The aldosterone levels were significantly greater in umbilical veins and artery than in maternal peripheral veins. Plasma aldosterone, estradiol, progesterone and hCG concentrations declined rapidly soon after removal of the placenta. The significant correlation between plasma aldosterone and the other three hormones was found in terms of the rate of disappearance from the circulation.(ABSTRACT TRUNCATED AT 250 WORDS)
Niibe
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Department of Obstetrics and Gynecology, Dokkyo University School of Medicine, Tochigi.
D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D006063:Chorionic Gonadotropin / Q000097:blood; D004298:Dopamine / Q000502:physiology*; D018492:Dopamine Antagonists; D004958:Estradiol / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D008787:Metoclopramide; D049590:Postpartum Period / Q000097:blood / Q000378:metabolism; D011225:Pre-Eclampsia / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy / Q000097:blood / Q000378:metabolism*; D011263:Pregnancy Trimester, Third; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011863:Radioimmunoassay
D006063:Chorionic Gonadotropin; D018492:Dopamine Antagonists; D000450:Aldosterone; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D008787:Metoclopramide; D004298:Dopamine