title: Cerebral blood flow determination within the first 8 hours of cerebral infarction using stable xenon-enhanced computed tomography.
abstract: Cerebral blood flow mapping with stable xenon-enhanced computed tomography (Xe/CT) was performed in conjunction with conventional computed tomography (CT) within the first 8 hours after the onset of symptoms in seven patients with cerebral infarction. Six patients had hemispheric infarctions, and one had a progressive brainstem infarction. Three patients with very low (less than 10 ml/100 g/min) blood flow in an anatomic area appropriate for the neurologic deficit had no clinical improvement by the time of discharge from the hospital; follow-up CT scans of these three patients confirmed infarction in the area of very low blood flow. Three patients with moderate blood flow reductions (15-45 ml/100 g/min) in the appropriate anatomic area had significant clinical improvement from their initial deficits and had normal follow-up CT scans. One patient studied 8 hours after stroke had increased blood flow (hyperemia) in the appropriate anatomic area and made no clinical recovery.
authors.affiliation: Department of Neurology, University of Pittsburgh, Pennsylvania.
authors.forename: R L
authors.initials: RL
authors.lastname: Hughes
authors.forename: H
authors.initials: H
authors.lastname: Yonas
authors.forename: D
authors.initials: D
authors.lastname: Gur
authors.forename: R
authors.initials: R
authors.lastname: Latchaw
mesh_terms: D000368:Aged; D002544:Cerebral Infarction / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011877:Radionuclide Imaging; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes