Biodegradable microparticles for delivery of polypeptides and proteins.
Interest in the immobilization of polypeptides has caused various workers to develop methods for fabricating polypeptide-loaded microparticles from biodegradable polymers. A range of physical phenomena is used to form these microparticles. Thus far, all of the processes utilize a solvent or solvent combination. Selection of these solvents in such a manner that particles free of potentially harmful residual or entrapped material can be produced has not been discussed, but should receive full attention.
Spenlehauer
G
G
Biological Transport Laboratory, Washington University, St. Louis, Missouri 63130.
Spenlehauer-Bonthonneau
F
F
Thies
C
C
D001673:Biodegradation, Environmental; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D010455:Peptides / Q000008:administration & dosage*; D011108:Polymers; D011506:Proteins / Q000008:administration & dosage*; D012710:Serum Albumin, Bovine; D012997:Solvents
D010455:Peptides; D011108:Polymers; D011506:Proteins; D012997:Solvents; D012710:Serum Albumin, Bovine