title: Neurological outcome after out-of-hospital cardiac arrest. Prediction by cerebrospinal fluid enzyme analysis.
abstract: The prognostic value of cerebrospinal fluid (CSF) and serum neuron-specific enolase and brain-type creatine kinase isozyme (CK-BB) measurements was studied in 75 consecutive victims of out-of-hospital cardiac arrest. All patients with a CSF neuron-specific enolase level of more than 24 ng/mL 24 hours after cardiac arrest remained unconscious and died. The CSF CK-BB level was as reliable as an index of brain injury. Cerebrospinal fluid neuron-specific enolase, CSF CK-BB and serum neuron-specific enolase levels correlated with the neurological outcome at 3 months. Thus, the analysis of these enzymes in CSF seems to be useful in the early prognostic assessment of cardiac arrest victims.
authors.affiliation: Department of Neurology, University of Helsinki, Finland.
authors.forename: R O
authors.initials: RO
authors.lastname: Roine
authors.forename: H
authors.initials: H
authors.lastname: Somer
authors.forename: M
authors.initials: M
authors.lastname: Kaste
authors.forename: L
authors.initials: L
authors.lastname: Viinikka
authors.forename: S L
authors.initials: SL
authors.lastname: Karonen
mesh_terms: D000328:Adult; D000368:Aged; D003402:Creatine Kinase / Q000097:blood / Q000134:cerebrospinal fluid*; D006323:Heart Arrest / Q000097:blood / Q000134:cerebrospinal fluid* / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes; D008875:Middle Aged; D009420:Nervous System / Q000503:physiopathology*; D010751:Phosphopyruvate Hydratase / Q000097:blood / Q000134:cerebrospinal fluid*; D011379:Prognosis
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase; D010751:Phosphopyruvate Hydratase