[Distribution and binding of positional isomers of 125I-hippuran, 125I-benzoate and 125I-phenylacetate in the blood components of mice].
On examining the dependencies between the parameters characterizing the structure and distribution of substances of acid character in the blood of experimental mice in the in vitro conditions it was demonstrated that both plasma and erythrocyte binding are structurally dependent. With increasing lipophilicity, the values of the drug fraction bound to proteins in the separated plasma, the values of the fraction bound to plasma proteins in the samples of whole blood, and the distribution into the erythrocytes in a suspension of erythrocytes are increased. With increasing lipophilicity, the distribution into the erythrocytes in the samples of the whole blood and the fraction in the plasma blood fluid are decreased.
Husáková
M
M
Láznícek
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M
Kvĕtina
J
J
D000818:Animals; D001565:Benzoates / Q000493:pharmacokinetics*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D007465:Iodohippuric Acid / Q000493:pharmacokinetics*; D007536:Isomerism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010648:Phenylacetates / Q000493:pharmacokinetics*
D001565:Benzoates; D007457:Iodine Radioisotopes; D010648:Phenylacetates; D007465:Iodohippuric Acid; C025136:phenylacetic acid
Distribuce a vazba polohových izomerů 125I-hippuranu, 125I-benzoanu a 125I-fenyloctanu ve slozkách mysí krve.