The effect of vitamin D treatment on decreased levels of ATP and energy charge in the thoracic aorta of uraemic rats.
The contents of ATP, ADP, AMP and calcium in the thoracic aorta were determined in rats with moderate uraemia, and in rats with the same degree of uraemia following treatment with 1,25-dihydroxycholecalciferol (1,25-DHCC). The contents of ATP, ADP and total nucleotides were decreased in the thoracic aorta in the uraemic rats but not in uraemic rats following 1,25-DHCC treatment. The content of calcium in the aorta increased substantially in uraemic rats given 1,25-DHCC. The results indicate that the development of arterial calcifications in uraemic rats following vitamin D treatment is dissociated from an impaired energy metabolism, since vitamin D may simultaneously restore impaired energy metabolism and accumulate calcium in the aortic wall.
Krog
M
M
Department of Clinical Research II, University Hospital, Uppsala, Sweden.
Ejerblad
S
S
Johansson
H
H
Ronquist
G
G
D000227:Adenine Nucleotides / Q000032:analysis; D000255:Adenosine Triphosphate / Q000032:analysis*; D000818:Animals; D001013:Aorta, Thoracic / Q000032:analysis* / Q000187:drug effects; D004734:Energy Metabolism; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014511:Uremia / Q000378:metabolism*; D014807:Vitamin D / Q000494:pharmacology*
D000227:Adenine Nucleotides; D014807:Vitamin D; D000255:Adenosine Triphosphate