Cell cycle-specific variation of intracellular plasminogen activator activity in cultured human alveolar epithelial carcinoma and rat hepatoma cells.
Plasminogen activator activity was demonstrated in two carcinoma cell lines: A549 cells derived from a human alveolar epithelial carcinoma; and ZHC cells derived from a rat hepatoma. Both cells had intracellular plasminogen activator activity throughout their cell cycles and in each case this activity reached a maximum. For A549 cells the maximal activity took place either during the G2 phase or in the course of the S to G2 transition, suggesting that plasminogen activator might play a role in cell division. For ZHC cells, the maximal activity occurred at the start of the S phase, suggesting that in these cells plasminogen activator might be involved in DNA replication.
Orfanoudakis
G
G
Laboratoire de Biologie Cellulaire, Faculté de Pharmacie, Université Louis Pasteur, Illkirch, France.
Zaoui
D
D
Befort
J J
JJ
Bieth
J G
JG
D000818:Animals; D002277:Carcinoma; D006801:Humans; D008114:Liver Neoplasms, Experimental; D008175:Lung Neoplasms; D010960:Plasminogen Activators / Q000378:metabolism*; D051381:Rats; D013936:Thymidine; D014407:Tumor Cells, Cultured / Q000166:cytology* / Q000378:metabolism
D010960:Plasminogen Activators; D013936:Thymidine