title: An antitumor principle from Euphorbia lathyris.
abstract: The extract of seeds of Euphorbia lathyris L. showed antitumor activity against Sarcoma 180 ascites in mice. Systematic fractionation of the extract led to the characterization of ingenol-3-hexadecanoate as an active principle, together with an inactive diterpene ingenol-20-hexadecanoate.
authors.forename: H
authors.initials: H
authors.lastname: Itokawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ichihara
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Takeya
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010946:Plants, Medicinal / Q000032:analysis*; D012510:Sarcoma 180 / Q000188:drug therapy*
chemical_list: D000972:Antineoplastic Agents, Phytogenic