[The effect of the protease inhibitor FUT-175 on phospholipase A2, complement, prostaglandins and prekallikrein during endotoxin shock].
This experiment was performed to investigate the effect of protease inhibitor FUT on the blood pressure, phospholipase A2, complement 3, CH50, thromboxane B2, 6-keto-PGF1 alpha and prekallikrein during endotoxin shock using 19 dogs. LPS was injected at a dose of 3mg.kg-1 in 11 dogs. Eight dogs were injected with FUT of 2mg.kg-1 before administration of LPS, and then infused continuously with 50 micrograms.kg-1.min-1 of FUT. FUT suppressed a decrease in the blood pressure, activations of phospholipase A2 and prekallikrein, but had no effect on serum TXB2, 6-keto-PGF1 alpha, C3 and CH50 compared with the LPS alone group. Suppression of the activation in phospholipase A2 and the falling of the blood pressure suggests that FUT has indirect effects such as inhibition of prekallikrein system.
Okuda
Y
Y
Ogata
H
H
D000818:Animals; D001550:Benzamidines; D003176:Complement C3 / Q000032:analysis*; D004285:Dogs; D006146:Guanidines / Q000494:pharmacology*; D010740:Phospholipases / Q000097:blood*; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D011288:Prekallikrein / Q000032:analysis*; D011453:Prostaglandins / Q000097:blood*; D011480:Protease Inhibitors / Q000494:pharmacology*; D012772:Shock, Septic / Q000097:blood*
D001550:Benzamidines; D003176:Complement C3; D006146:Guanidines; D011453:Prostaglandins; D011480:Protease Inhibitors; D011288:Prekallikrein; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; C032855:nafamostat