title: Anthropological survey on red cell glutathione peroxidase (GPX1) polymorphism in central western Africa: a tentative hypothesis on the interaction between GPX1*2 and Hb beta *S allelic products.
abstract: Phenotype and allele frequencies for erythrocyte glutathione peroxidase (GPX1) polymorphism are reported in the Mbugu and Sango (Central African Republic), Goun (Benin), and Bamileke (Cameroon) ethnic groups. The GPX1*2 allele frequencies (from 0.012 in the Sango to 0.058 in the Bamileke) fit into the range of the data already known for the Subsaharan populations. The value of GPX1*2 for study of the genetic admixture between Negro and Pygmy populations is suggested. Three different unusual GPX1 electrotypes are described. Finally, we hypothesize an interaction between GPX1*2 and Hb beta*S allelic products occurring in the sickle cells infected by Plasmodium falciparum.
authors.affiliation: Department of Human and Animal Biology, University of Rome, La Sapienza, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Destro-Bisol
authors.forename: G
authors.initials: G
authors.lastname: Spedini
mesh_terms: D000483:Alleles; D001541:Benin; D002163:Cameroon; D002488:Central African Republic; D003223:Congo; D004912:Erythrocytes / Q000201:enzymology*; D005006:Ethnicity; D005787:Gene Frequency; D005979:Glutathione Peroxidase / Q000097:blood / Q000235:genetics*; D006451:Hemoglobin, Sickle / Q000235:genetics*; D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D006451:Hemoglobin, Sickle; D005979:Glutathione Peroxidase