title: Doppler left ventricular diastolic filling abnormalities in aortic stenosis and their relation to hemodynamic parameters.
abstract: Doppler mitral flow indexes and their relation to invasively measured hemodynamic diastolic indexes were assessed in 13 patients with isolated aortic stenosis (AS), and compared to Doppler indexes in 10 normal subjects matched for age, heart rate, left ventricular (LV) ejection fraction and LV load. Patients with AS showed no difference in Doppler early filling (E) indexes, but demonstrated greater Doppler atrial filling (A) indexes in comparison to normal subjects: atrial velocity (89 +/- 31 vs 56 +/- 7 cm/s), atrial integral (11.4 +/- 4.8 vs 5.7 +/- 1.6 cm), A/E velocity (1.69 +/- 0.89 vs 1.06 +/- 0.26) and A/E integral (3.53 +/- 6.64 vs 0.81 +/- 0.27) (all p less than 0.05). Doppler indexes in patients with AS did not correlate with hemodynamic indexes of LV relaxation or chamber stiffness. Significant correlations were observed between Doppler and angiographic peak filling rates (r = 0.70) and between Doppler atrial filling velocity and LV end-diastolic volume (r = -0.66), LV end-diastolic pressure (r = -0.48) and LV ejection fraction (r = 0.53) (all p less than 0.05). These data indicate that, compared to matched normal subjects, most patients with AS have an increased atrial contribution to LV filling. However, in patients with decreased LV function, atrial function may also be depressed, as indicated by a decreased atrial contribution to LV filling, resulting in "normalization" of the Doppler mitral flow pattern.
authors.affiliation: Department of Medicine/Cardiology, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: K H
authors.initials: KH
authors.lastname: Sheikh
authors.forename: T M
authors.initials: TM
authors.lastname: Bashore
authors.forename: D W
authors.initials: DW
authors.lastname: Kitzman
authors.forename: C J
authors.initials: CJ
authors.lastname: Davidson
authors.forename: T N
authors.initials: TN
authors.lastname: Skelton
authors.forename: M B
authors.initials: MB
authors.lastname: Honan
authors.forename: K B
authors.initials: KB
authors.lastname: Kisslo
authors.forename: M B
authors.initials: MB
authors.lastname: Higginbotham
authors.forename: J
authors.initials: J
authors.lastname: Kisslo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000175:diagnosis* / Q000503:physiopathology; D015150:Echocardiography, Doppler; D005260:Female; D006325:Heart Atria / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000503:physiopathology; D009200:Myocardial Contraction