Anti-inflammatory activity of 5,7-dimethoxyflavone.
The anti-inflammatory activity of 5,7-dimethoxyflavone (5,7-DMF) has been assessed. It was found to possess a comparable effect to aspirin on the rat paw edema model, and it showed no inhibition on cotton pellet-induced granuloma formation. On the rat pleurisy model, 5,7-DMF exhibited an antiexudative effect, interfered with leukocyte migration, and markedly inhibited prostaglandin biosynthesis. In addition, 5,7-DMF caused marked lowering of the rectal temperature of rats. The results obtained from Hippocratic screening revealed that 5,7-DMF possessed a weak CNS depressant activity.
Panthong
A
A
Tassaneeyakul
W
W
Kanjanapothi
D
D
Tantiwachwuttikul
P
P
Reutrakul
V
V
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy; D005260:Female; D005334:Fever / Q000188:drug therapy; D005419:Flavonoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006099:Granuloma / Q000188:drug therapy; D008297:Male; D010946:Plants, Medicinal / Q000032:analysis; D010998:Pleurisy / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; C060298:5,7-dimethoxyflavone