[Activity of key enzymes of heme metabolism and the content of several hemoproteins in the liver of rats of various ages].
The activity of key enzymes of heme metabolism (delta-aminolevulinate synthase, EC 2.3.1.37, and heme oxygenase, EC 1.14.99.3) and the content of some hemoproteins were examined in the liver of male Wistar rats aged 1, 3 and 24 months. It is established that the activity of delta-aminolevulinate synthase decreases when rats reach the age of 3 months and remains at the same level in rats aged 24 months. The content of microsomal cytochrome P450 and the activity of tryptophan-2,3-dioxygenase holoenzyme increase when rats reach the age of 3 months. The total tryptophan-2,3 dioxygenase activity is higher in animals aged 24 months as compared to those aged 1 month. The heme oxygenase activity and the content of microsomal cytochrome b5 do not change with age.
Kaliman
P A
PA
Nikitchenko
I V
IV
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006418:Heme / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D006420:Hemeproteins / Q000378:metabolism*; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014366:Tryptophan Oxygenase / Q000378:metabolism
D006420:Hemeproteins; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D006418:Heme; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D014366:Tryptophan Oxygenase; D006419:Heme Oxygenase (Decyclizing); D000624:5-Aminolevulinate Synthetase
Aktivnost' kliuchevykh fermentov metabolizma gema i soderzhanie nekotorykh gemoproteidov v pecheni krys raznogo vozrasta.