Effect of alpha-naphthylisothiocyanate on blood clearance of 99mTc-phytate in rats.
The effect of alpha-naphthylisothiocyanate (ANIT) on blood clearance of 99mTc-phytate (99mTc-P) in rats was examined, and blood clearance test of 99mTc-P was compared with the cases of serum transaminase test, serum bilirubin test or histological test of the liver. The disappearance rate of 99mTc-P from blood decreased with the increase in dose of ANIT and with the passage of time after the ANIT administration. Changes of the blood clearance of 99mTc-P after ANIT treatment in rats may be influenced by the disorder in the hepatocytes rather than in the bile ductule cells. The blood clearance test of 99mTc-P in rats showed a sensitive reaction for the acute hepatic dysfunction induced by ANIT equally to the serum transaminase test, the serum bilirubin test or the histological test of the liver.
Shibata
H
H
Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.
Hisano
T
T
Katoh
H
H
D015058:1-Naphthylisothiocyanate / Q000633:toxicity*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D008111:Liver Function Tests / Q000379:methods; D008297:Male; D008657:Metabolic Clearance Rate; D009942:Organometallic Compounds / Q000097:blood* / Q000493:pharmacokinetics; D015609:Organotechnetium Compounds; D010833:Phytic Acid / Q000097:blood* / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D013861:Thiocyanates / Q000633:toxicity*
D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D013861:Thiocyanates; C026177:technetium phytate; D015058:1-Naphthylisothiocyanate; D010833:Phytic Acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin