[Plasma concentrations of ornidazole in newborn infants and infants after iterative administration].
Ornidazole was administered for ten days to twelve hospitalized neonates at the same daily dose of 20 mg/kg either by one or two IV infusions. Minimum steady-state concentrations measured between the 4th and 10th day ranged from 7.8 to 17.3 (mean = 11.8 +/- 3.2 mg/l) for one daily infusion and from 10.9 to 26.6 (mean = 20.5 +/- 6 mg/l) for two infusions. These minimum concentrations were all above the minimum inhibitory concentration for the most clinically significant anaerobic bacteria. So the single daily administration of ornidazole at the dose of 20 mg/kg is sufficient to obtain therapeutic efficiency.
Turcant
A
A
Granry
J C
JC
Sorin
M
M
Allain
P
P
Cavellat
M
M
D001424:Bacterial Infections / Q000097:blood; D004066:Digestive System Diseases / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D009593:Nitroimidazoles / Q000097:blood*; D009950:Ornidazole / Q000008:administration & dosage / Q000097:blood*; D013997:Time Factors
D009593:Nitroimidazoles; D009950:Ornidazole
Concentrations plasmatiques d'ornidazole chez le nouveau-né et chez le nourrisson après administration répétée.