Effects of calcitonin on morphine tolerance and withdrawal syndrome in morphine physically dependent rats.
We investigated the effect of acute or chronic peripheral administration of [Asu1.7]eel-calcitonin on the development of tolerance to the analgesic effect of morphine and on the naloxone-precipitated withdrawal syndrome in morphine-dependent rats. Neither the analgesic effect of acute morphine nor the development of tolerance to the antinociceptive effect of this drug was modified by calcitonin. However, the chronic but not the acute administration of calcitonin attenuated some signs and symptoms of morphine withdrawal.
Clementi
G
G
Institute of Pharmacology, University of Catania School of Medicine, Italy.
Valerio
C
C
Prato
A
A
Caruso
A
A
Patti
F
F
Patanè
S
S
Drago
F
F
D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D004361:Drug Tolerance; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence / Q000503:physiopathology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
D009270:Naloxone; D009020:Morphine; D002116:Calcitonin