title: Aztreonam in the treatment of aerobic, gram-negative bacillary infections in pediatric patients.
abstract: Aztreonam was administered to 20 children diagnosed as having any of the following infections: urinary tract infection, pneumonia, meningitis, and abscess of the appendix. Haemophilus influenzae, Escherichia coli, and Klebsiella pneumoniae were isolated. The minimum inhibitory concentrations of aztreonam for these bacteria ranged from 0.03 to 0.5 micrograms/ml. All patients were clinically and bacteriologically cured within 5-16 days of treatment. Six months after completion of therapy, patients who had had meningitis appeared to be free of any neurologic sequelae. The antibiotic was well tolerated by all patients.
authors.affiliation: Corporación para Investigaciones Biológicas, Medellin, Colombia.
authors.forename: H
authors.initials: H
authors.lastname: Trujillo
authors.forename: N
authors.initials: N
authors.lastname: Harry
authors.forename: A
authors.initials: A
authors.lastname: Arango
authors.forename: G
authors.initials: G
authors.lastname: Benítez
authors.forename: F
authors.initials: F
authors.lastname: Restrepo
authors.forename: G I
authors.initials: GI
authors.lastname: Mejía
authors.forename: A L
authors.initials: AL
authors.lastname: Castrillón
mesh_terms: D000038:Abscess / Q000188:drug therapy; D000332:Aerobiosis; D001065:Appendix; D001398:Aztreonam / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D002429:Cecal Diseases / Q000188:drug therapy; D002675:Child, Preschool; D005260:Female; D006090:Gram-Negative Bacteria; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008581:Meningitis / Q000188:drug therapy; D011014:Pneumonia / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D001398:Aztreonam