Familial correlates of risk: application to the Gershon and Goldin NIMH pedigree data.
Survival analysis of familial covariates of risk for affective illness demonstrated a significant effect on the proband's diagnosis when affection status included bipolar illness, but not major depressive disorder. A cohort effect was indicated only when broad spectra (including bipolar II and major depressive disorder) of illness were defined. Multifactorial analyses of familial correlations for affective illness evidenced neither sex-specific correlations nor prevalences. We suggest the examination of risk variables prior to undertaking familial analysis.
Gilligan
S B
SB
Division of Biological and Biomedical Sciences, Washington University, St. Louis, MO 63110.
Rice
J P
JP
D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000235:genetics*; D010375:Pedigree; D012307:Risk Factors