The pharmacologic activity of complexes and mixtures with copper and salicylates or aminopyrine following oral dosing in rats.
Cu(II) complexes with salicylates or aminopyrine were administered to rats with local inflammation (acute paw oedema elicited with carrageenan) to determine their anti-inflammatory activity and ulcerogenic effects following oral administration. The complexes were more effective than the parent ligands or appropriate mixtures of these ligands with Cu(II) as anti-inflammatory agents. All complexes indicated low ulcerogenity. The differences in pharmacologic activity between the complexes and mixtures in question are discussed.
Korolkiewicz
Z
Z
Department of Pharmacology, Medical Academy, Gdańsk, Poland.
Hać
E
E
Gagało
I
I
Gorczyca
P
P
Lodzińska
A
A
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002351:Carrageenan; D003300:Copper / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D007249:Inflammation; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012459:Salicylates / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D013276:Stomach Ulcer / Q000139:chemically induced*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009942:Organometallic Compounds; D012459:Salicylates; C025564:copper salicylate complex; D003300:Copper; D002351:Carrageenan