Fatty acid acylated antibodies against virus suppress its reproduction in cells.
A method for suppression of virus reproduction in cells using fatty acylated antiviral antibodies, which in contrast to non-modified antibodies are capable of intracellular penetration, has been suggested. The addition of stearoylated antiviral antibodies to influenza A/Chili virus-infected cells causes a 100-fold suppression of virus reproduction. Non-modified antibodies do not produce any effect on virus reproduction.
Kabanov
A V
AV
Research Center of Molecular Diagnostics, USSR Ministry of Health, Moscow.
Ovcharenko
A V
AV
Melik-Hubarov
N S
NS
Bannikov
A I
AI
Alakhov VYu
Kiselev
V I
VI
Sveshnikov
P G
PG
Kiselev
O I
OI
Levashov
A V
AV
Severin
E S
ES
D000215:Acylation; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D005227:Fatty Acids; D009980:Influenza A virus / Q000276:immunology / Q000502:physiology*; D051379:Mice; D014779:Virus Replication
D000914:Antibodies, Viral; D005227:Fatty Acids