Fluoride bioavailability from disodium monofluorophosphate fluoridated milk in children and rats.
The aim of the present work was to study the usefulness of disodium monofluorophosphate (MFP) as a milk-fluoridating agent by measuring the bioavailability of F from MFP in milk relative to that of F from NaF in water. Long-term (multiple-dose) studies were performed on rats measuring F bone uptake. The relative F absorption from MFP in milk was also determined in preschool children by means of 24-hour F urinary excretion. In both studies F absorption was determined either under fasting conditions or when F ingestion occurred together with food intake. The results show that F absorption from MFP in milk is as high as that of NaF in water under fasting conditions and that the F bioavailability decrease from NaF in water is more important than that of MFP in milk when F ingestion occurs simultaneously with food intake.
Villa
A
A
Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago.
Guerrero
S
S
Cisternas
P
P
Monckeberg
F
F
D000042:Absorption; D000818:Animals; D001682:Biological Availability; D001842:Bone and Bones / Q000032:analysis; D002675:Child, Preschool; D005260:Female; D005459:Fluorides / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D008297:Male; D008892:Milk / Q000032:analysis; D010710:Phosphates / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000008:administration & dosage
D010710:Phosphates; C012980:fluorophosphate; D012969:Sodium Fluoride; D005459:Fluorides