Immunoglobulin allotyping (Gm, Km) of GAW5 families.
The following Gm and Km immunoglobulin allotypes were determined on the Genetic Analysis Workshop 5 insulin-dependent diabetes mellitus (GAW5 IDDM) families: G1m (1,2,3,17), G2m (23), G3m (5,10,11,13,14,21,28) and Km (1,3). Since the allotype G2m (23) has been rarely studied, due to paucity of typing reagents, it was of interest to compare the frequency of the halotype encoding this allotype in parents of North American GAW5 IDDM families with the frequency found in a previous investigation of healthy North Americans. Results indicated very similar frequencies of Gm haplotypes in the two groups.
Field
L L
LL
Department of Pediatrics, Alberta Children's Hospital, Calgary, Canada.
Dugoujon
J M
JM
D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D005060:Europe; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000032:analysis*; D007129:Immunoglobulin Gm Allotypes / Q000032:analysis*; D009656:North America; D012494:Sampling Studies
D007126:Immunoglobulin Allotypes; D007129:Immunoglobulin Gm Allotypes