Enhancement of colloid uptake by tumor cell surface electrical charge modification.
Colloidal [51Cr]chromic phosphate uptake is considerably increased by preincubation of P388 ascites leukemia cells with poly(DL-lysine). The uptake increase is in direct relationship with the concentration and the degree of polymerization of poly(DL-lysine). The probable implication of cell surface electrical charge modification in these phenomena is discussed.
Anghileri
L J
LJ
Laboratory of Biophysics, Faculty of Medicine, University of Nancy, France.
Maincent
P
P
Robert
J
J
D000818:Animals; D002857:Chromium / Q000493:pharmacokinetics; D017608:Chromium Compounds; D003102:Colloids; D007941:Leukemia P388 / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D010710:Phosphates / Q000493:pharmacokinetics; D011107:Polylysine / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000378:metabolism*
D017608:Chromium Compounds; D003102:Colloids; D010710:Phosphates; D002857:Chromium; D011107:Polylysine; C509369:chromic phosphate