title: Age-dependent differences in energetic status, electrical and mechanical performance of rat myocardium.
abstract: Transmembrane action potential (AP), isotonic contraction and biochemical measurements were performed in 12-day, 1-, 3-, 14- and 24-month-old rat hearts. The major findings of this study are: (1) the AP and contraction duration decrease between 12 days and 1 month of age (growth period) and increase between 1 month and 24 months of age; (2) as compared with 1 month and 14 months, respectively, isotonic contraction peak shortening is lower at 12 days and 24 months of age; (3) the phosphorylation potential is higher during the postnatal period and decreases in an age-correlated manner; (4) the inorganic phosphate and glycogen contents are higher in the senescent heart. We conclude that, during the postnatal period the particular AP and the lower mechanical performances could be the result of immature sarcolemma and sarcoplasmic reticulum properties rather than modifications in the oxidative phosphorylation mechanism and by contrast, in senescent heart, that AP and contraction modifications could result from metabolic modifications.
authors.affiliation: Université Joseph Fourier, Laboratoire de Physiologie cellulaire animale, Grenoble, France.
authors.forename: T
authors.initials: T
authors.lastname: Jullien
authors.forename: F
authors.initials: F
authors.lastname: Cand
authors.forename: C
authors.initials: C
authors.lastname: Fargier
authors.forename: J
authors.initials: J
authors.lastname: Verdetti
mesh_terms: D000200:Action Potentials; D000375:Aging / Q000502:physiology*; D000818:Animals; D004734:Energy Metabolism; D005260:Female; D006003:Glycogen / Q000378:metabolism; D006321:Heart / Q000502:physiology*; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D010085:Oxidative Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006003:Glycogen