Pharmacological activity of the essential oil of Bupleurum gibraltaricum: anti-inflammatory activity and effects on isolated rat uteri.
The essential oil of Bupleurum gibraltaricum showed considerable anti-inflammatory activity against carrageenan-produced pedal edema in rats. This appeared to be due to the delta-3-carene component. The essential oil and delta-3-carene both produced qualitatively similar changes in rat uterine contractions caused by oxytocin (a progressive dose-related modification of the concentration-response curves) and acetylcholine (non-progressive modification of the concentration-response curves).
Ocete
M A
MA
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Granada, Spain.
Risco
S
S
Zarzuelo
A
A
Jimenez
J
J
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000081008:Bicyclic Monoterpenes; D004487:Edema / Q000188:drug therapy; D005260:Female; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D039821:Monoterpenes; D010121:Oxytocin / Q000494:pharmacology; D010938:Plant Oils / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000081008:Bicyclic Monoterpenes; D039821:Monoterpenes; D010938:Plant Oils; D013729:Terpenes; D010121:Oxytocin; C030218:3-carene; D000109:Acetylcholine; D007213:Indomethacin