Lack of nephrotoxicity of styrene at current TLV level (50 ppm).
Biochemical markers of kidney damage were examined in 37 female workers exposed to an average concentration of 225 mg/m3 of styrene. The concentration of mandelic acid in urine was on the average 759 mg/g creatinine. The mean duration of employment of the exposed subjects was 11 years. The results were compared to those obtained in 35 control female workers matched for age and a number of demographic and lifestyle factors and with no history of exposure to organic solvents. No difference was found in the urinary excretion of albumin, beta 2-microglobulin, retinol-binding protein, total proteins, glucose, lysozyme, lactate dehydrogenase and beta-N-acetyl-D-glucosaminidase. The present study provides thus further evidence that exposure to styrene at the current TLV (215 mg/m3) does not entail any detectable risk for the renal function.
Vyskocil
A
A
Department of Hygiene, Medical Faculty, Charles University, Hradec Kralové, Czechoslovakia.
Emminger
S
S
Malir
F
F
Fiala
Z
Z
Tusl
M
M
Ettlerova
E
E
Bernard
A
A
D000328:Adult; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000652:urine; D008333:Mandelic Acids / Q000652:urine; D008452:Maximum Allowable Concentration; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000652:urine; D020058:Styrene; D013343:Styrenes / Q000009:adverse effects*
D008333:Mandelic Acids; D013343:Styrenes; D020058:Styrene; C037938:mandelic acid