[Stabilization of hemoglobin by aldehydes in reactions of autooxidation to methemoglobin].
Aldehydes cause the retardation of hemoglobin autooxidation to methemoglobin. The protective effect is due to semimercaptal formation between aldehydes and sulfhydryl groups of cysteine++ 93 of the oxyhemoglobin beta-chain. The efficiency of hemoglobin protection of different aldehydes depends on the correlation between the equilibrium constants of carbonyl compound binding to protein sulfhydryl or amino groups and their electron accepting properties.
Stepuro
I I
II
Kashko
M F
MF
D000447:Aldehydes / Q000494:pharmacology*; D005292:Ferricyanides; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008706:Methemoglobin / Q000378:metabolism*; D010084:Oxidation-Reduction; D010108:Oxyhemoglobins / Q000032:analysis
D000447:Aldehydes; D005292:Ferricyanides; D006454:Hemoglobins; D010108:Oxyhemoglobins; D008706:Methemoglobin; C028033:potassium ferricyanide
Stabilizatsiia gemoglobina al'degidami v reaktsiiakh autookisleniia v metgemoglobin.