[A model of the interclonal interactions in chronic myeloleukemia].
A new model of chronic myelogenous leukemia (CML) pathogenesis based on the idea of some cellular clones dominance over the others at the stem cells level is described. The model gives good explanations to all basic clinical variants of CML as well as to all well-known cytological phenomena to be found recently in this type of leukemia. The most probable mechanisms which might be responsible for the above-mentioned phenomenon of dominance between different cellular clones are discussed.
Mamaev
N N
NN
Gushchin
V A
VA
D002450:Cell Communication; D002999:Clone Cells / Q000473:pathology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology* / Q000473:pathology; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000209:etiology / Q000473:pathology; D008954:Models, Biological; D010677:Philadelphia Chromosome
Model' mezhklonal'nykh vzaimodeĭstviĭ pri khronicheskom mieloleĭkoze.