title: Sclerosing cholangitis with hepatic microvesicular steatosis in cystic fibrosis and chronic pancreatitis.
abstract: The association between asymptomatic primary sclerosing cholangitis and exocrine pancreatic disease was underlined by the findings in a patient with cystic fibrosis and in another with chronic pancreatitis. In each case hepatocytes showed extensive microvesicular steatosis and studies of drug metabolism suggested hepatic enzyme induction: biliary or serum analysis, or both, disclosed raised concentrations of a lipid-based marker of free radical oxidation. These findings suggest that toxic metabolites of oxygen or other chemicals may have a role in the pathogenesis of the bile duct lesion.
authors.affiliation: University Department of Gastroenterology, Royal Infirmary, Manchester.
authors.forename: I
authors.initials: I
authors.lastname: Benett
authors.forename: B
authors.initials: B
authors.lastname: Salh
authors.forename: N Y
authors.initials: NY
authors.lastname: Haboubi
authors.forename: J M
authors.initials: JM
authors.lastname: Braganza
mesh_terms: D000328:Adult; D015209:Cholangitis, Sclerosing / Q000150:complications / Q000473:pathology*; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000150:complications / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D010195:Pancreatitis / Q000150:complications / Q000473:pathology*