Investigation of leukocyte accumulation and vascular permeability changes in the rat sponge implantation model.
Acute inflammation was induced in rats by subcutaneous implantation of saline-soaked polyester sponges. Leukocyte depletion with vinblastine leukocyte accumulation and partly inhibited the vascular permeability at 6 h and increased it at 24 h. Complement depletion with cobra venom factor inhibited leukocyte accumulation at 6 h only and had little effect on vascular permeability. The cyclooxygenase inhibitor tiaprofenic acid inhibited leukocyte accumulation with a greater effect at 24 h and also inhibited vascular permeability at this time.
Hambleton
P T
PT
Roussel Laboratories Ltd., Wilts, U.K.
Miller
P
P
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D004546:Elapid Venoms / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D005122:Exudates and Transudates / Q000378:metabolism; D007249:Inflammation / Q000503:physiopathology*; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D011422:Propionates / Q000494:pharmacology; D051381:Rats; D014747:Vinblastine / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004546:Elapid Venoms; D011422:Propionates; C016310:cobra venom factor; C021270:tiaprofenic acid; D014747:Vinblastine