[Changes of laboratory hematologic indices in patients with chronic glomerulopathies following treatment with superhigh doses of cyclophosphamide].
41 patients with active glomerulopathies treated with super high doses of Cyclophosphamide were studied. The following indices were followed up dynamically: hemoglobin concentration, number and morphology of erythrocytes, number and morphology of leucocytes and differential count. Hemoglobin concentration and erythrocyte count remain in the reference ranges in most of the patients. They fall more considerably compared to the initial values between the 90-120 day after the treatment. This fall improves spontaneously and does not require discontinuance of the treatment. The single application of super high dose of Cyclophosphamide does not influence significantly the leucopoiesis. Because of the parallel application of glucocorticosteroids no fall of the leucocyte count is observed and they remain in their reference ranges.
Tishkov
I
I
Penev
M
M
Bŭnkova
M
M
Lazarov
V
V
Milkov
V
V
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004906:Erythrocyte Count / Q000187:drug effects; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000097:blood* / Q000188:drug therapy; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008181:Lupus Nephritis / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000097:blood* / Q000188:drug therapy; D013997:Time Factors
D006454:Hemoglobins; D003520:Cyclophosphamide
Promeni v niakoi khematologichni laboratorni pokazetali pri bolni s khronichni glomerulopatii sled lechenie sŭs svrŭkhvisoki dozi tsiklofosfamid.