title: [Arthropathies following the administration of pefloxacin to an adolescent with mucoviscidosis].
abstract: We report the occurrence of knee joint effusion with prolonged functional impairment in a 17-year old boy with cystic fibrosis treated with pefloxacin for recurrent lower respiratory tract infections caused by Pseudomonas aeruginosa. Because the quinolone pefloxacin fairly often induces joint disease in pediatric age groups, we advocate restricting its use to those patients whose growth is completed. In growing individuals, it seems reasonable to use second generation quinolones only in infections caused by resistant organisms and to avoid exerting the joints during treatment.
authors.forename: A
authors.initials: A
authors.lastname: Kesseler
authors.forename: A
authors.initials: A
authors.lastname: Lacassie
authors.forename: J P
authors.initials: JP
authors.lastname: Hugot
authors.forename: P
authors.initials: P
authors.lastname: Talon
authors.forename: D
authors.initials: D
authors.lastname: Thomas
authors.forename: L
authors.initials: L
authors.lastname: Astier
mesh_terms: D000293:Adolescent; D003550:Cystic Fibrosis / Q000150:complications*; D006801:Humans; D007592:Joint Diseases / Q000139:chemically induced*; D007719:Knee Joint; D008297:Male; D015366:Pefloxacin / Q000009:adverse effects*; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000209:etiology; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000209:etiology
chemical_list: D015366:Pefloxacin
vernacular_title: Arthropathies consécutives à l'administration de péfloxacine chez un adolescent atteint de mucoviscidose.