Effect of long-term ingestion of asbestos fibres in rats.
The effects of ingested asbestos fibres were studied in Wistar Han rats. Chrysotile and a mixture of chrysotile/crocidolite (75%/25%) in palm oil were given for 24 months to 70 males and 70 females per group (daily doses 10, 60 and 360 mg); one control group was fed with normal diet, a second with normal diet plus palm oil. The animals were observed for a further 6 months after the end of the treatment. The results indicate that ingestion of asbestos fibres at high doses had no toxic effects and did not affect animal survival; in addition, there was no evidence of carcinogenic effects.
Truhaut
R
R
Laboratoire de Toxicologie et Hygiène Industrielle, Faculté des Sciences Pharmaceutiques, Paris, France.
Chouroulinkov
I
I
D000284:Administration, Oral; D000818:Animals; D001194:Asbestos / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000209:etiology / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001194:Asbestos