Dietary modulation of the progression of nephropathy in aging rats: an evaluation of the importance of protein.
Chronic nephropathy involving glomerular sclerosis markedly progresses in severity with age in male Fischer 344 rats fed ad libitum. Restricting food intake by 40% almost totally prevents progression of these lesions. Restricting food intake by 40% without restricting protein intake is also highly effective although somewhat less so than food restriction that includes protein restriction. These findings indicate that reducing the intake of protein is not the major reason for the retardation by food restriction of the age-associated progression of nephropathy in rats.
Masoro
E J
EJ
Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756.
Iwasaki
K
K
Gleiser
C A
CA
McMahan
C A
CA
Seo
E J
EJ
Yu
B P
BP
D000375:Aging; D000818:Animals; D001835:Body Weight; D004044:Dietary Proteins / Q000008:administration & dosage*; D004435:Eating; D005508:Food Deprivation; D005767:Gastrointestinal Diseases / Q000517:prevention & control; D006331:Heart Diseases / Q000517:prevention & control; D007674:Kidney Diseases / Q000517:prevention & control*; D008107:Liver Diseases / Q000517:prevention & control; D008136:Longevity; D008297:Male; D009374:Neoplasms, Experimental / Q000517:prevention & control; D009929:Organ Size; D051381:Rats; D011916:Rats, Inbred F344; D012098:Reproduction
D004044:Dietary Proteins