[Effectiveness of various schedules of drug therapy of patients with sarcoidosis of the respiratory organs].
One hundred and seventeen patients with active sarcoidosis of the respiratory organs were treated according to 4 therapy regimens based on the use of corticosteroid drugs. Intermittent use of the corticosteroids was shown to be the most efficient (in 98.5 per cent). It allowed to lower the course dose by 25-30 per cent and to reduce the frequency of complications to 1.5 per cent. Inspite of high efficacy of kenalog 40, its use was limited because of adverse reactions in 19.2 per cent of the patients. It was difficult to eliminate the adverse reactions because of the drug prolonged action. The use of presocyl provided improvement in 62 per cent of the patients having contraindications for corticosteroid therapy. Patients with marked pneumosclerotic lesions should be treated with simultaneous use of corticosteroids and azathioprine.
Ozerova
L V
LV
Stepanian
I E
IE
Romanov
V V
VV
Kireeva
T A
TA
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D001241:Aspirin / Q000627:therapeutic use; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use; D002738:Chloroquine / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004338:Drug Combinations / Q000627:therapeutic use; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy*; D008206:Lymphatic Diseases / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000188:drug therapy*; D014222:Triamcinolone Acetonide / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D004338:Drug Combinations; C014772:presocyl; D002738:Chloroquine; D011239:Prednisolone; D014222:Triamcinolone Acetonide; D001379:Azathioprine; D001241:Aspirin
Effektivnost' razlichnykh rezhimov medikamentoznogo lecheniia bol'nykh sarkoidozom organov dykhaniia.