Late-onset familial amyloid polyneuropathy in an American family of English origin.
Recent advances permit biochemical and genetic classification of familial amyloidotic polyneuropathy. We report a family with the methionine-30 prealbumin variant, which is atypical in late age of onset and the appearance of proximal arm weakness before more typical generalized neuropathy.
Kincaid
J C
JC
Department of Medicine, Indiana University School of Medicine, Indianapolis.
Wallace
M R
MR
Benson
M D
MD
D000368:Aged; D000686:Amyloidosis / Q000235:genetics*; D001345:Autoradiography; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000032:analysis; D004739:England; D005789:Genealogy and Heraldry; D014644:Genetic Variation; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000235:genetics*; D010449:Peptide Mapping; D011228:Prealbumin / Q000235:genetics; D014481:United States
D011228:Prealbumin; D004247:DNA