title: [Optimization of the composition of granular materials for the preparation of a diazepam-containing suspension].
abstract: The composition of auxiliary substances in granular material for the preparation of a diazepam containing suspension for veterinary use was studied. By means of an experimental plan regression models of the physico-mechanical parameters of the preparation were developed. Variants of optimized compositions meeting certain demands regarding the bulk volume, the flow angle, the relative sediment height and the viscosity were elaborated in order to choose the most qualified variant which has to guarantee a high quality of the ready-made drug.
authors.affiliation: Chemisch-Pharmazeutisches Forschungsinstitut (NIHFI) Sofia, VR Bulgarien.
authors.forename: I
authors.initials: I
authors.lastname: Dimitrova
authors.forename: E
authors.initials: E
authors.lastname: Welikova
authors.forename: H
authors.initials: H
authors.lastname: Iontschev
mesh_terms: D002626:Chemistry, Pharmaceutical; D003975:Diazepam / Q000008:administration & dosage*; D011208:Powders; D013535:Suspensions
chemical_list: D011208:Powders; D013535:Suspensions; D003975:Diazepam
vernacular_title: Optimierung von Granulatzusammensetzungen zur Anfertigung einer diazepamhaltigen Suspension.