Urinary and faecal excretion of pyrene and hydroxypyrene by rats after oral, intraperitoneal, intratracheal or intrapulmonary application.
The urinary and faecal excretion of pyrene and 1-hydroxypyrene after oral (53.4%), intraperitoneal (3.1%), intratracheal (30-37%) and intrapulmonary application (0.003%) to rats has been determined by means of gas chromatography/mass spectrometry and the excretion rates were found to depend on the mode of application. With regard to the low urinary excretion rates, 1-hydroxypyrene seems not to be very suitable as a biological marker for PAH exposure to man.
Jacob
J
J
Biochemical Institute for Environmental Carcinogens, Grosshansdorf, F.R.G.
Brune
H
H
Gettbarn
G
G
Grimmer
D
D
Heinrich
U
U
Mohtashamipur
E
E
Norpoth
K
K
Pott
F
F
Wenzel-Hartung
R
R
D000818:Animals; D005243:Feces / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D008954:Models, Biological; D011721:Pyrenes / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
D011721:Pyrenes; C033146:1-hydroxypyrene