Application of diethylstilbestrol dipropionate in bulls. II. Residues in bile, liver, kidney, muscle tissues and application site.
The second part of an experiment is described in which 20 one year old bulls were injected with diethylstilbestrol (DES) dipropionate containing preparations. Analysis of DES content was performed in several tissues, such as the injection site, diaphragm muscle, psoas muscle, liver, kidney and bile. In the injection site appreciable amounts of DES were found. Measurable amounts of DES were also found in liver and kidney until 4 weeks after injection. In bile, DES concentrations were even higher than those in urine, and were well correlated with DES concentrations in urine. Implications for screening purposes are discussed.
Jansen
E H
EH
National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
van den Berg
R H
RH
Both-Miedema
R
R
van Blitterswijk
H
H
Stephany
R W
RW
D000818:Animals; D001646:Bile / Q000032:analysis / Q000378:metabolism*; D002417:Cattle / Q000378:metabolism*; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D007273:Injections, Intramuscular; D007668:Kidney / Q000032:analysis / Q000378:metabolism*; D008099:Liver / Q000032:analysis / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000032:analysis / Q000378:metabolism*; D014018:Tissue Distribution
D004054:Diethylstilbestrol; C000937:diethylstilbestrol dipropionate