title: Massed amygdaloid kindling in encéphale isolé cats: its facilitation by naloxone.
abstract: The effect of repetitive administration of naloxone on the development of massed amygdaloid kindling in 'encéphale isolé' cats was studied. Electrical amygdaloid kindling was carried out with a 15 min inter-stimulus interval (ISI) in a control situation with intravenous (i.v.) naloxone administration (2, 4, and 8 mg/kg), 5 min prior to amygdaloid stimulation. It was found that it was possible to complete the amygdaloid kindling process in the encéphale isolé preparation reaching generalized electrographic tonic-clonic self-sustained seizures. The enhancement of the duration, frequency, and propagation of the after-discharge (AD) was accentuated by naloxone which also induced a progressive amplitude increment of the first potential evoked by the onset of the tetanus. The number of trials needed to achieve seizure generalization was reduced in dose-dependent manner by naloxone. The ability of naloxone to accelerate the development of amygdaloid kindling may be related to an inhibitory role of opioid peptides in this process.
authors.affiliation: División de Investigaciones en Neurociencias, UNAM, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Fernández-Guardiola
authors.forename: L
authors.initials: L
authors.lastname: Rocha
authors.forename: F
authors.initials: F
authors.lastname: Pellicer
authors.forename: R
authors.initials: R
authors.lastname: Gutiérrez
authors.forename: J M
authors.initials: JM
authors.lastname: Calvo
mesh_terms: D000679:Amygdala; D000818:Animals; D002415:Cats; D003292:Convulsants / Q000494:pharmacology*; D003655:Decerebrate State / Q000503:physiopathology*; D004723:Endorphins / Q000502:physiology*; D005260:Female; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D012640:Seizures / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D003292:Convulsants; D004723:Endorphins; D009270:Naloxone