title: A novel pathway for transversion mutation induced by dCTP misincorporation in a mutator strain of CHO cells.
abstract: Intracellular imbalances of dCTP produce both T----C transitions and an unusual class of transversions (A----C) at the aprt locus of CHO cells. Our data suggest that this transversion pathway is the consequence of dCTP:T mispairs which are not efficiently proofread during DNA replication.
authors.affiliation: Clare Hall Laboratories, Imperial Cancer Research Fund, South Mimms, Hertfordshire, United Kingdom.
authors.forename: G
authors.initials: G
authors.lastname: Phear
authors.forename: M
authors.initials: M
authors.lastname: Meuth
mesh_terms: D000818:Animals; D001482:Base Composition; D001483:Base Sequence; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004260:DNA Repair; D004261:DNA Replication; D003845:Deoxycytosine Nucleotides / Q000235:genetics* / Q000378:metabolism; D005260:Female; D009154:Mutation; D010053:Ovary
chemical_list: D003845:Deoxycytosine Nucleotides; C024107:2'-deoxycytidine 5'-triphosphate