Variations in serum sorbitol dehydrogenase, aspartate transaminase, and isoenzyme 5 of lactate dehydrogenase activities in horses given carbon tetrachloride.
Seven horses were given 0.5 mg of carbon tetrachloride/kg of body weight via a nasogastric tube. Subsequent hepatocellular damage was monitored by serum enzyme determinations of sorbitol dehydrogenase, isoenzyme 5 of lactate dehydrogenase, and aspartate transaminase activities. Creatinine kinase activity was evaluated as an indicator of muscle cell damage. Sorbitol dehydrogenase, isoenzyme 5 of lactate dehydrogenase, and aspartate transaminase activities were significantly (P less than 0.05) increased by 24 hours after carbon tetrachloride administration. Isoenzyme 5 of lactate dehydrogenase and sorbitol dehydrogenase activities returned to baseline several days before aspartate transaminase activity returned to baseline. Creatine kinase activity remained unchanged.
Bernard
W V
WV
Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Kennett Square 19348.
Divers
T J
TJ
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury; D004796:Clinical Enzyme Tests / Q000662:veterinary; D005260:Female; D006734:Horse Diseases / Q000139:chemically induced / Q000175:diagnosis*; D006736:Horses; D007527:Isoenzymes; D007064:L-Iditol 2-Dehydrogenase / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008107:Liver Diseases / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D013401:Sugar Alcohol Dehydrogenases / Q000097:blood*
D007527:Isoenzymes; D002251:Carbon Tetrachloride; D013401:Sugar Alcohol Dehydrogenases; D007064:L-Iditol 2-Dehydrogenase; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases