title: Mortality in pediatric paratesticular rhabdomyosarcoma: a multivariate analysis.
abstract: We performed a retrospective analysis of 28 children presenting with confirmed paratesticular embryonal rhabdomyosarcoma to examine factors predictive of fatal outcome. Complete surgery, defined as radical inguinal orchiectomy with clear microscopic margins plus radical, retroperitoneal lymph node dissection with extirpation of all gross disease, was performed in 21 patients (75 per cent). All patients received chemotherapy and 20 received radiation therapy according to protocol. Of the patients 16 have survived for more than 5 years with no evidence of disease. Univariate analysis revealed that only the presence of parenchymal metastases at diagnosis (p less than or equal to 0.040) and unresectability (p less than or equal to 0.003) were significant predictors of fatal outcome. Multivariate analysis showed that unresectability was the most important predictor of mortality with an estimated relative risk of 5.8.
authors.affiliation: Department of Surgery (Pediatric and Urologic Surgery), Memorial Sloan-Kettering Cancer Center, New York, New York.
authors.forename: M P
authors.initials: MP
authors.lastname: LaQuaglia
authors.forename: F
authors.initials: F
authors.lastname: Ghavimi
authors.forename: G
authors.initials: G
authors.lastname: Heller
authors.forename: H
authors.initials: H
authors.lastname: Herr
authors.forename: L R
authors.initials: LR
authors.lastname: Mandell
authors.forename: M
authors.initials: M
authors.lastname: Corbally
authors.forename: S
authors.initials: S
authors.lastname: Hajdu
authors.forename: P
authors.initials: P
authors.lastname: Exelby
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D005834:Genital Neoplasms, Male / Q000401:mortality* / Q000628:therapy; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D009919:Orchiectomy; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000401:mortality* / Q000628:therapy; D012307:Risk Factors; D013223:Statistics as Topic; D013736:Testicular Neoplasms / Q000401:mortality* / Q000628:therapy