title: Genetic effects of 131I in reproductive cells of male mice.
abstract: A study was made of the frequencies of dominant lethal mutations (DLM) in pre- and post-meiotic germ cells, reciprocal translocations (RT) in spermatogonia and abnormal sperm heads (ASH) induced by a single intraperitoneal administration of Na131I with an activity of 1.48-740 kBq/g to male mice. The frequency of DLM was shown to increase only when postmeiotic cells were exposed to the radionuclide. The RT frequency increased insignificantly with increases in the dose of 131I. The ASH frequency increased only when maximal doses of 131I were administered. The relative biological efficiency (RBE) of 131I with reference to the indices under study is less than 1.
authors.affiliation: N.I. Vavilov Institute of General Genetics, U.S.S.R. Academy of Sciences, Moscow.
authors.forename: V A
authors.initials: VA
authors.lastname: Shevchenko
authors.forename: L K
authors.initials: LK
authors.lastname: Ramaya
authors.forename: M D
authors.initials: MD
authors.lastname: Pomerantseva
authors.forename: A M
authors.initials: AM
authors.lastname: Lyaginskaya
authors.forename: S I
authors.initials: SI
authors.lastname: Dementiev
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005313:Fetal Death; D005720:Gamma Rays; D005799:Genes, Dominant; D005804:Genes, Lethal; D007457:Iodine Radioisotopes / Q000633:toxicity*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D011247:Pregnancy; D013093:Spermatogonia / Q000528:radiation effects*; D013094:Spermatozoa / Q000002:abnormalities / Q000528:radiation effects*; D014178:Translocation, Genetic
chemical_list: D007457:Iodine Radioisotopes