Behavioral effects of neurotensin: operant responding and assessment of 'anhedonia'.
Neurotensin and antipsychotic drugs share certain properties. This study investigates whether neurotensin and neuroleptics share the ability to produce 'anhedonia'. A dose-response curve for the effect of neurotensin on continuously reinforced behavior was obtained in Experiment 1. Centrally administered neurotensin reduced food-reinforced responding. Based on the results of Experiment 1, a dose of neurotensin (0.95 micrograms) was chosen which had minimal effects on food-reinforced operant responding. To test for anhedonia, repeated presentations of this dose were given. Because response rates did not decrease over repeated testing, no evidence for anhedonia was found.
Rossitch
E
E
Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710.
King
R A
RA
Luttinger
D
D
Nemeroff
C B
CB
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005502:Food; D007275:Injections, Intravenous; D008297:Male; D009496:Neurotensin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology
D009496:Neurotensin