Distribution and pharmacokinetics of precocene-II in the tick Ornithodoros parkeri (Acari: Argasidae).
Injected [3H]precocene-II spread from the hemocoel of Ornithodoros parkeri (Cooley) ticks to gut, salivary glands, synganglion, ovary, and the remainder of the body (carcass). Analyses at 2, 24, and 48 h after injection of precocene revealed that radioactivity remained at low levels in the synganglia and ovaries of fed-mated and fed-virgin females. Radioactivity increased gradually during 48 h after injection in salivary glands of fed-mated and fed-virgin ticks. It also increased gradually in the gut of fed virgins but not in fed-mated females. The carcasses contained the majority of total radioactivity at 2, 24, and 48 h after injection. Most of the radioactivity was found in ether-soluble compounds and only minimal amounts in water-soluble metabolites. Analysis of tick excreta and washings indicate that female O. parkeri excrete injected precocene very slowly; only 6% of total radioactivity was recovered in these samples during the 48 h after injection. Thin-layer chromatographic analyses of ether extracts of salivary glands and carcasses from fed-mated ticks 24 h after injection showed that the majority of the injected [3H]precocene-II was present in unchanged form.
Zhu
X X
XX
Oliver
J H
JH
Vogel
G N
GN
D000818:Animals; D001578:Benzopyrans / Q000493:pharmacokinetics*; D007306:Insecticides / Q000493:pharmacokinetics*; D007605:Juvenile Hormones / Q000037:antagonists & inhibitors*; D010944:Plants; D013987:Ticks / Q000378:metabolism*
D001578:Benzopyrans; D007306:Insecticides; D007605:Juvenile Hormones; C014163:precocene II