title: Receptors for epidermal growth factor and sex steroid hormones in human colorectal carcinomas.
abstract: Iodinated epidermal growth factor was used to identify its specific receptor in 32 human colorectal carcinomas. The receptor was found in 25% of the tumors with values between 6.9 - 104.0 fmoles/mg DNA. Receptors for estrogen and progesterone were detected in 45 and 25% of the tumors respectively. No correlation was observed between short term survival and content of receptors for sex steroid hormones. Four of the 8 patients with detectable levels of epidermal growth factor receptor had experienced relapse.
authors.affiliation: Department of Surgery, Södersjukhuset, Stockholm, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Magnusson
authors.forename: A V
authors.initials: AV
authors.lastname: Rosen
authors.forename: R
authors.initials: R
authors.lastname: Nilsson
authors.forename: A
authors.initials: A
authors.lastname: Macias
authors.forename: R
authors.initials: R
authors.lastname: Perez
authors.forename: L
authors.initials: L
authors.lastname: Skoog
mesh_terms: D002277:Carcinoma / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000032:analysis*; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D066246:ErbB Receptors