Cephradine penetration of mandibular bone.
The concentration of cephradine in serum and mandibular bone was assayed in 22 patients undergoing third molar surgery following a single 1-g intramuscular injection. Serum and cortical bone samples taken simultaneously contained mean cephradine concentrations of 12.41 micrograms/mL and 1.25 micrograms/g, respectively. These results, when compared with those reported for other bony sites, including femoral head and knee, show a reduced bone penetration with a bone-to-serum ratio of approximately 0.10:1.
Middlehurst
R J
RJ
Department of Oral and Maxillofacial Surgery, University of Manchester Dental Hospital, England.
Pedlar
J
J
Barker
G R
GR
Rood
J P
JP
D000328:Adult; D002511:Cephalosporins / Q000493:pharmacokinetics*; D002515:Cephradine / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000378:metabolism*; D008875:Middle Aged; D008964:Molar, Third; D011292:Premedication; D014081:Tooth Extraction; D014095:Tooth, Impacted / Q000601:surgery
D002511:Cephalosporins; D002515:Cephradine