title: 19-Hydroxy-4-androsten-17-one: potential competitive inhibitor of estrogen biosynthesis.
abstract: 3-Deoxy steroids having a 4-ene system were found to be competitive inhibitors of human placental aromatase. 19-Hydroxy-4-androsten-17-one (2) potently inhibits the enzyme with an apparent Ki of 12.5 nM, but does not produce a time-dependent inactivation of the enzyme.
authors.affiliation: Tohoku College of Pharmacy, Sendai, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Numazawa
authors.forename: A
authors.initials: A
authors.lastname: Mutsumi
authors.forename: K
authors.initials: K
authors.lastname: Hoshi
authors.forename: R
authors.initials: R
authors.lastname: Koike
mesh_terms: D000735:Androstenedione / Q000031:analogs & derivatives / Q000494:pharmacology; D000738:Androsterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D047072:Aromatase Inhibitors; D001665:Binding Sites; D001667:Binding, Competitive; D002384:Catalysis; D004967:Estrogens / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007700:Kinetics; D008861:Microsomes / Q000201:enzymology; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D013329:Structure-Activity Relationship
chemical_list: D047072:Aromatase Inhibitors; D004967:Estrogens; C059926:19-hydroxy-4-androsten-17-one; D000735:Androstenedione; D000738:Androsterone