[Suppression of tumor growth in the liver by cis-diamminedichloroplatinum as large oligolamellar liposomes prepared by freezing and thawing].
A/HeJ mice with experimental metastases of HA-1 tumor in the liver and other organs were given therapeutic doses of cisplatin, free or encapsulated in phosphatidylcholine cholesterol freeze-thawed liposomes, intravenously. Free cisplatin treatment was found to decrease the growth rate of liver metastases by half and to extend survival by 1.5 times as compared to controls. The inhibitory effect of liposome-encapsulated cisplatin on hepatic metastases growth was more pronounced than that of the free drug although it weakly affected metastatic growth in other organs.
Kaledin
V I
VI
Nikolin
V P
VP
Popova
N A
NA
Budker
V G
VG
Semenova
L A
LA
D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D005615:Freezing; D007275:Injections, Intravenous; D008081:Liposomes; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D008722:Methods; D051379:Mice; D008805:Mice, Inbred A; D009368:Neoplasm Transplantation; D013997:Time Factors
D004337:Drug Carriers; D008081:Liposomes; D002945:Cisplatin
Podavlenie opukholevogo rosta v pecheni tsisdiamminodikhlorplatinom v sostave bol'shikh oligolamelliarnykh liposom, prigotovlennykh metodom zamorazhivaniia i ottaivaniia.