Prostanoid production in post-gastrectomy gastritis. Influence of sucralfate.
Prostaglandins seem to play an important role in the protection of the gastric mucosa, but the effect of cytoprotective drugs such as sucralfate on prostaglandin synthesis and in the prevention of gastritis induced by gastric surgery has not been definitely established. The purpose of this study was to determine: (1) the prostanoid production and the histologic changes occurring after various surgical techniques in rat gastric mucosa; and (2) the influence of sucralfate treatment on prostanoid levels and gastric damage induced by gastric surgery. Animals included in the study had undergone one of three surgical procedures: Billroth I, Billroth II, or truncal vagotomy plus pyleroplasty. Animals that had no surgery and "sham-operated" animals were used as controls. One third of the animals in each group received sucralfate treatment (an average of 100 mg/kg per day). Samples of gastric mucosa were taken after one year, and prostaglandin E2 (PGE2), 6-keto-PGF1 alpha, and thromboxane B2 synthesis were measured by radioimmunoassay. The sucralfate-treated group consistently showed higher PGE2 and 6-keto-PGF1 alpha values and a higher 6-keto-PGF1 alpha:thromboxane B2 ratio, as well as lower thromboxane B2 levels than untreated animals, although the differences were statistically significant only in the 6-keto-PGF1 alpha:thromboxane B2 ratio. Similarly, gastritis was more frequent and more severe in the untreated animals. In conclusion, sucralfate seems to provide protection against gastritis induced by gastric surgery and increases the 6-keto-PGF1 alpha:thromboxane B2 ratio.
Payno
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Digestive Surgery Department, Jimenez Diaz Foundation, Madrid, Spain.
Lopez-Novoa
J M
JM
Rodriguez-Puyol
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D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D005743:Gastrectomy / Q000379:methods; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D005756:Gastritis / Q000209:etiology / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013392:Sucralfate / Q000494:pharmacology*; D013929:Thromboxane B2 / Q000096:biosynthesis; D015167:Vagotomy, Truncal
D011453:Prostaglandins; D013392:Sucralfate; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D015232:Dinoprostone