Organ-specific antibodies against ovary in patients with systemic lupus erythematosus.
We studied whether patients with systemic lupus erythematosus can have organ-specific antibodies directed against ovaries. With a recently developed enzyme-linked immunosorbent assay system that uses both a soluble and an extractable corpus luteum antigen fraction, we detected both IgG and IgM antibodies in the sera of patients with systemic lupus erythematosus (16 of 19, 84%). The highest levels of IgG antibodies were seen when the extractable organ fraction (ST80) was used as the antigen.
Moncayo-Naveda
H
H
Department of Gynecology and Obstetrics, University of Ulm, Germany.
Moncayo
R
R
Benz
R
R
Wolf
A
A
Lauritzen
C
C
D000906:Antibodies / Q000032:analysis*; D000918:Antibody Specificity; D002308:Cardiolipins / Q000276:immunology; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D010053:Ovary / Q000276:immunology*
D000906:Antibodies; D002308:Cardiolipins