Response of upper limb blood flow to handgrip exercise after Blalock-Taussig operation (for tetralogy of Fallot) or subclavian flap operation (for aortic isthmic coarctation).
To evaluate the effects of long-term reductions in perfusion pressure on blood flow responses to increased functional demand, 5 patients (aged 12 to 26 years) without normal aortic to subclavian artery blood flow to 1 arm as a result of surgery to treat congenital heart disease were studied. Five age- and sex-matched healthy (control) subjects were also studied. In the patients, forearm blood flow was not different in the surgical and normal arms at rest (3.6 +/- 0.6 vs 4.0 +/- 0.7 ml/min/100 ml, respectively, mean +/- standard error, difference not significant) despite lower systolic blood pressure in the surgical arm (87 +/- 2 vs 115 +/- 2 mm Hg, p less than 0.05). The increases in heart rate, systolic blood pressure, forearm electromyographic activity (index of muscle fatigue) and postexercise forearm blood flow (index of muscle oxygen deficit) were not different in response to 2.5 minutes of submaximal rhythmic handgrip exercise (50% of maximal force) performed with the surgical versus the normal arms. Peak forearm blood flow elicited by combined ischemia and maximal isometric handgrip exercise was not significantly different in surgical and normal arms in the group as a whole (39 +/- 4 vs 43 +/- 3 ml/min/100 ml, difference not significant), although some bilateral deficit (20 to 38%) was observed in 2 patients. No bilateral differences were observed in the control subjects under any condition. The finding of normal physiologic adjustments to submaximal rhythmic handgrip exercise with the surgical arm suggests that oxygen delivery during exercise was adequate.(ABSTRACT TRUNCATED AT 250 WORDS)
Joyner
M J
MJ
Department of Exercise and Sport Sciences, University of Arizona, Tucson 85721.
Chase
P B
PB
Allen
H D
HD
Seals
D R
DR
D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D001017:Aortic Coarctation / Q000601:surgery*; D001132:Arm / Q000098:blood supply*; D002648:Child; D004576:Electromyography; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D009119:Muscle Contraction; D011184:Postoperative Period; D012039:Regional Blood Flow; D013348:Subclavian Artery / Q000601:surgery*; D013771:Tetralogy of Fallot / Q000601:surgery*; D013997:Time Factors