title: Magnetic resonance imaging determination of myometrial invasion in endometrial carcinoma.
abstract: Fifteen patients with FIGO stage I biopsy confirmed endometrial adenocarcinoma underwent preoperative pelvic magnetic resonance imaging (MRI) to evaluate the presence and depth of myometrial invasion. Imaging was performed with a Diasonics superconducting imaging system operating at 0.35 T (15 MHz); multislice multi-spin-echo pulse sequences were used exclusively, with 5-mm contiguous sections. All patients then received primary therapy consisting of abdominal hysterectomy and bilateral salpingo-oophorectomy. Imaging findings were then compared with the uterine specimen histopathology. MRI was accurate in predicting the presence or absence of invasion in 13 of 15 cases (87%) and was able to discriminate superficial from deep invasion in 9 of 11 cases (82%). Based on our findings, we conclude that MRI appears to be an excellent technique for determining myometrial invasion, and that it may play a significant role in the preoperative planning of a thorough search for lymphatic spread in those patients considered to be at high risk by virtue of myometrial invasion.
authors.affiliation: Department of Obstetrics and Gynecology, University of Texas, Southwestern Medical School, Dallas 75235-9032.
authors.forename: R
authors.initials: R
authors.lastname: Yazigi
authors.forename: J
authors.initials: J
authors.lastname: Cohen
authors.forename: A K
authors.initials: AK
authors.lastname: Munoz
authors.forename: J
authors.initials: J
authors.lastname: Sandstad
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009215:Myometrium / Q000473:pathology*; D009361:Neoplasm Invasiveness; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000473:pathology