title: 2-substituted derivatives of benzimidazole inhibiting gastric acid secretion in rats.
abstract: Benzimidazole and its 2-derivatives with amino, carbamonitrile, urea, and guanidine groups have been tested for their activity on gastric secretory process. The carbamonitrile-, urea-, and guanidine compounds decrease gastric acid secretion, basal and stimulated with histamine or betazole, in Shay-rats and depress the guinea pig auricle activity stimulated by betazole. The results suggest that the studied 2-substituted benzimidazole compounds exhibit anti H2-histamine activity.
authors.affiliation: Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pinelli
authors.forename: S
authors.initials: S
authors.lastname: Trivulzio
authors.forename: L
authors.initials: L
authors.lastname: Malvezzi
authors.forename: G
authors.initials: G
authors.lastname: Rossoni
authors.forename: L
authors.initials: L
authors.lastname: Beretta
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D001625:Betazole / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats
chemical_list: D001562:Benzimidazoles; D001625:Betazole; D006632:Histamine