title: [Hepatitis probably caused by exifone (Adlone)].
abstract: Exifone, a drug recently proposed for the treatment of cognitive deficiencies of old age, has been marketed in France beginning in April 1988. This report concerns 2 patients who developed jaundice after taking this drug for 2 and 5 months, respectively. Serum aminotransferase was markedly increased. There was no hepatic failure. In both cases, histologic examination of a liver sample showed centrilobular hepatocyte necrosis and cholestasis. Necrotic cells were infiltrated with numerous red blood cells and scarce inflammatory cells. These lesions were associated with alterations of the walls of centrilobular veins. Discontinuation of exifone was followed by the prompt disappearance of jaundice. Complete recovery occurred within 6 and 12 weeks, respectively.
authors.affiliation: Unité de Recherches de Physiopathologie Hépatique (INSERM U-24), Hôpital Beaujon, Clichy, Paris.
authors.forename: D
authors.initials: D
authors.lastname: Larrey
authors.forename: P
authors.initials: P
authors.lastname: Biclet
authors.forename: A
authors.initials: A
authors.lastname: Razafimahaleo
authors.forename: C
authors.initials: C
authors.lastname: Degott
authors.forename: B
authors.initials: B
authors.lastname: Devergie
authors.forename: G
authors.initials: G
authors.lastname: Babany
authors.forename: J F
authors.initials: JF
authors.lastname: Mosnier
authors.forename: J Y
authors.initials: JY
authors.lastname: Scoazec
authors.forename: G
authors.initials: G
authors.lastname: Feldmann
authors.forename: D
authors.initials: D
authors.lastname: Pessayre
mesh_terms: D000368:Aged; D001577:Benzophenones / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000009:adverse effects*
chemical_list: D001577:Benzophenones; D011619:Psychotropic Drugs; C052932:exifone
vernacular_title: Hépatites probablement dues à l'exifone (Adlone).