Thyroxine influences neuronal connectivity in the adult frog brain.
In contrast to results of earlier investigations the influence of thyroxine on CNS connectivity is not restricted to circum-metamorphic stages in frogs. Neuroanatomical findings in adult Xenopus treated with thyroxine reveal a spread of the ipsilateral retino-tectal projection. Sprouting fibers establish a tectal innervation pattern similar to the one found in primitive fish. The question arises, whether thyroxine also has morphogenetic effects in the mature CNS of other species.
Hofmann
M H
MH
Department of Anatomy, School of Medicine, University of Goettingen, F.R.G.
Michler
A
A
Meyer
D L
DL
D000818:Animals; D005260:Female; D006735:Horseradish Peroxidase; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects*; D012160:Retina / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D013477:Superior Colliculi / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D013974:Thyroxine / Q000494:pharmacology*; D013997:Time Factors; D014981:Xenopus
D006735:Horseradish Peroxidase; D013974:Thyroxine