title: Sparsomycin analogs. VI. Synthesis and antitumor activity of octylsparsomycin analogs.
abstract: Five sparsomycin analogs (9-13) were prepared and examined for their ability to inhibit deoxyribonucleic acid (DNA) synthesis in L5178Y lymphoma cells. All of the compounds showed significant activity in the DNA synthesis assay. The compounds having Rc configuration exhibited almost the same activities independently of the configuration at the sulfoxide sulfur atom. Among the Sc isomers, the Rs configuration was advantageous for the appearance of activity.
authors.forename: S
authors.initials: S
authors.lastname: Kanatomo
authors.forename: T
authors.initials: T
authors.lastname: Hase
authors.forename: A
authors.initials: A
authors.lastname: Wada
authors.forename: K
authors.initials: K
authors.lastname: Ohki
authors.forename: S
authors.initials: S
authors.lastname: Nagai
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D007940:Leukemia L5178 / Q000473:pathology; D051379:Mice; D013033:Sparsomycin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects*
chemical_list: D000903:Antibiotics, Antineoplastic; D013033:Sparsomycin; C040555:octylsparsomycin