Conformational analysis of antifolates: molecular structure and enzyme binding of the 4'-COOH trimethoprim derivative.
Cody
V
V
Molecular Biophysics Department, Medical Foundation of Buffalo, Inc., New York 14203.
Sutton
P A
PA
D000818:Animals; D001665:Binding Sites; D002645:Chickens; D015195:Drug Design; D008099:Liver / Q000201:enzymology; D008958:Models, Molecular; D008968:Molecular Conformation; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*; D014295:Trimethoprim / Q000031:analogs & derivatives* / Q000378:metabolism*
D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase