title: [The effect of incorporation technics of water soluble macromolecular binders on the properties of fluidized-bed dried granules].
abstract: Five binders characterized by particle size and dissolution rate have been studied in order to evaluate their qualification for fluidized-bed granulation. For this purpose they were applied as powder and solution, respectively. Quality parameters of the granules and tablets obtained were compared. Compared with solutions of binders the dry incorporation of the binder led to a slower growth of the granules mainly depending on the dissolution rate of the binders. Due to this fact the formulations showed a decreased strength except PVP (high dissolution rate) which causes an increased growth of the granules at the same time. A size reduction of binders with a low dissolution rate led to tablets with characteristics of strength similar to the findings when solutions of binders were used, whereas the growth of granules remained uninfluenced.
authors.affiliation: Sektion Chemie, Humboldt-Universität zu Berlin.
authors.forename: M
authors.initials: M
authors.lastname: Richter
authors.forename: H W
authors.initials: HW
authors.lastname: Rahn
authors.forename: R
authors.initials: R
authors.lastname: Voigt
mesh_terms: D002626:Chemistry, Pharmaceutical; D005079:Excipients; D010316:Particle Size; D011208:Powders; D012995:Solubility; D013607:Tablets
chemical_list: D005079:Excipients; D011208:Powders; D013607:Tablets
vernacular_title: Zum einfluss der Einarbeitungstechnik von wasserlöslichen makromolekularen Bindemitteln auf die Eigenschaften von Wirbelschichtgranulaten und der daraus hergestellten Komprimate.