title: Repetitive complete and partial hydatidiform mole.
abstract: Fifteen patients with repetitive hydatidiform mole were followed at the New England Trophoblastic Disease Center between 1965-1988. The medical records were examined to determine the patients' age, gravidity, parity, clinical presentation, development of post-molar tumor, and subsequent pregnancy experience. Each molar tissue was reviewed pathologically. Seven patients had repetitive complete hydatidiform mole and three developed persistent post-molar disease after their later mole. Five patients had an initial complete hydatidiform mole followed by a partial hydatidiform mole; two developed persistent post-molar disease after the partial mole. One patient had an initial partial hydatidiform mole followed by a complete hydatidiform mole and required chemotherapy after her complete mole. Two patients had repetitive partial hydatidiform mole, and neither developed post-molar disease. Four of the patients with repetitive mole later achieved a normal viable pregnancy. Molar pregnancies must be categorized as either complete or partial to provide meaningful data concerning repetitive hydatidiform mole.
authors.affiliation: Department of Obstetrics and Gynecology, New England Trophoblastic Disease Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: L W
authors.initials: LW
authors.lastname: Rice
authors.forename: J M
authors.initials: JM
authors.lastname: Lage
authors.forename: R S
authors.initials: RS
authors.lastname: Berkowitz
authors.forename: D P
authors.initials: DP
authors.lastname: Goldstein
authors.forename: M R
authors.initials: MR
authors.lastname: Bernstein
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000473:pathology*; D009364:Neoplasm Recurrence, Local; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000473:pathology*