Quantitative evaluation of chlortoluran-induced splenic hemosiderosis by means of an image analyzer.
This study investigated a technique for the quantification of hemosiderin layed down in the spleen. The model used was the rat to which the urea-based herbicide chlortoluran was fed for 90 days. There was good correlation between hematological, biochemical, histological and image analytical techniques when splenic hemosiderosis was of a moderate to severe degree. Where hemosiderosis was of a slight nature, only the technique of image analysis was able to detect the on-going changes.
Nyska
A
A
Life Science research Israel, Nes Ziona.
Waner
T
T
Scolnik
M
M
Zuckerman
A
A
Pirak
M
M
Kuehnberg
W
W
Gordon
E B
EB
D000818:Animals; D001663:Bilirubin / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D006486:Hemosiderosis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D006540:Herbicides / Q000633:toxicity*; D007091:Image Processing, Computer-Assisted; D009929:Organ Size / Q000187:drug effects; D010671:Phenylurea Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013158:Splenic Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology
D006540:Herbicides; D010671:Phenylurea Compounds; D001663:Bilirubin; C007033:chlortoluron