Histoarchitecture of the genital tract of ovariectomized rats treated with an aqueous extract of Moringa oleifera roots.
The effect of an aqueous extract of Moringa oleifera roots was studied histologically on the genital tract of ovariectomized rats in the presence and absence of estradiol dipropionate and progesterone. Administration of the extract itself stimulated the uterine histoarchitecture as revealed by increases in the height of luminal epithelium, well developed glands, loose stroma and rich vascularity. The cervix showed metaplastic changes in the epithelium with marked keratinization. In the vagina, cornification was very prominent, rugae increased and stroma was loose. Conjoint administration of the extract with estradiol showed a synergistic action, and an inhibition was observed when administered conjointly with progesterone.
Shukla
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Laboratory of Reproductive Biology, School of Studies in Zoology, Jiwaji University, Gwalior, India.
Mathur
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R
Prakash
A O
AO
D000019:Abortifacient Agents / Q000494:pharmacology*; D000020:Abortifacient Agents, Nonsteroidal / Q000494:pharmacology*; D000818:Animals; D002584:Cervix Uteri / Q000187:drug effects / Q000473:pathology; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects* / Q000473:pathology; D010052:Ovariectomy; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000187:drug effects / Q000473:pathology; D014621:Vagina / Q000187:drug effects / Q000473:pathology
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D010936:Plant Extracts; D011374:Progesterone; D004958:Estradiol