Determination of isosorbide-5-mononitrate in tablets by differential pulse polarography.
A differential pulse polarographic method requiring little sample separation was developed for the determination of isosorbide-5-mononitrate in tablet dosage form with the standard addition technique and without interference from common excipients. Britton-Welford buffer (pH 3.0) was used as the supporting electrolyte, the single peak occurring at -0.36 V vs. a reference Ag/AgCl electrode. The irreversible, diffusion controlled, two-electron reduction process at the dropping mercury electrode permits a precise and accurate determination of the active ingredient in the 0.4-20 microgram/ml concentration range.
Pinzauti
S
S
La Porta
E
E
Gratteri
P
P
Papeschi
G
G
Giannellini
V
V
D007202:Indicators and Reagents; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives* / Q000032:analysis; D011048:Polarography; D013607:Tablets
D007202:Indicators and Reagents; D013607:Tablets; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate