[Appraisal of the protective effect of vitamin E against CCl4 liver poisoning].
VE (at dosage of 200mg/kg) significantly depressed the liver microsomal lipid peroxidation induced by 50 mg/kg CCl4; on the other hand, VE potentiated the SGPT, or liver triglyceride, or liver microsomal cytochrome P450 during CCl4 poisoning. The interaction between VE and CCl4 should be carefully taken in to consideration, especially when using VE in preventing and curing CCl4 poisoning.
Tang
N
N
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000009:adverse effects / Q000627:therapeutic use*
D014810:Vitamin E