Enhancing effects of luteinizing hormone-releasing hormone on testicular damage induced by di-(2-ethylhexyl)phthalate in rats.
The administration of 1.5 g/kg of di-(2-ethylhexyl)phthalate (DEHP), 50 or 10 micrograms/kg of luteinizing hormone-releasing hormone (LRH) to male Crj:Wistar rats for 1 week did not affect their testicular and prostatic gland weights. Co-administration of DEHP and LRH, however, induced testicular atrophy coincident with decreases in zinc and sulfhydryl concentration in the testis and reduction of the activity of testicular specific lactate dehydrogenase isozyme. These changes were similar to the results of high-dose administration of DEHP alone. Liver enlargement and hypolipidemia (reduction of serum cholesterol, triglycerides and phospholipids) occurred sometimes after co-administration of DEHP and LRH.
Oishi
S
S
Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
D000818:Animals; D001284:Atrophy; D001835:Body Weight / Q000187:drug effects; D004051:Diethylhexyl Phthalate / Q000633:toxicity*; D004357:Drug Synergism; D008055:Lipids / Q000097:blood; D007986:Luteinizing Hormone / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010795:Phthalic Acids / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000032:analysis; D013737:Testis / Q000032:analysis / Q000187:drug effects* / Q000473:pathology; D015032:Zinc / Q000032:analysis
D008055:Lipids; D010795:Phthalic Acids; D013438:Sulfhydryl Compounds; D007986:Luteinizing Hormone; D004051:Diethylhexyl Phthalate; D015032:Zinc