title: [Comparative study of the effect of the thymus preparations thymoptin and thymalin on fibrin-monomer polymerization].
abstract: Thymoptin was shown to possess the ability of lysis of the nonstabilized fibrin in vitro and of increasing the nonenzymatic fibrinolytic activity of blood plasma after eight daily intramuscular injections to rats in doses of 1 and 100 micrograms/kg body weight and during incubation with purified fibrin monomer to produce its depolymerization. Thymalin possessed no nonenzymatic fibrinolytic activity in vitro and in contrast to thymoptin at a relatively high concentration (1000 and 100 micrograms/ml) enhanced fibrin-monomer polymerization.
authors.forename: V E
authors.initials: VE
authors.lastname: Pastorova
authors.forename: L A
authors.initials: LA
authors.lastname: Liapina
authors.forename: I P
authors.initials: IP
authors.lastname: Ashmarin
authors.forename: B A
authors.initials: BA
authors.lastname: Kudriashov
authors.forename: V D
authors.initials: VD
authors.lastname: Zazhireĭ
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D013949:Thymus Extracts / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D005343:Fibrinolytic Agents; D013949:Thymus Extracts; D013951:Thymus Hormones; C011468:fibrinmonomer; C032805:thymalin
vernacular_title: Sravnitel'noe izuchenie vliianiia timusnykh preparatov timoptina i timalina na polimerizatsiiu fibrin-monomera.