[Background impulsation of cortical neurons during blockade of synaptic inhibition in vital slices].
Investigation of the picrotoxin effect on the background neuronal activity was performed in guinea-pig cerebral cortex slices maintained in vitro. Extracellular recording showed that the blockade of GABA-ergic inhibition did not change characteristics of spike trains significantly, although the stimulus-evoked reactions became epileptic. These data give evidence that the inhibition processes in the background activity of cortex slices are expressed extremely slightly and have no intrinsic influence on this activity.
Karnup
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SV
D000200:Action Potentials / Q000187:drug effects; D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects*; D010477:Perfusion; D010852:Picrotoxin / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects*
D000241:Adenosine; D010852:Picrotoxin
Fonovaia impul'satsiia korkovykh neĭronov pri blokade sinapticheskogo tormozheniia v perezhivaiushchikh srezakh.