[A study of blood rifampin concentration in smoking and non-smoking healthy individuals and in patients with tuberculosis].
The serum rifampin level after smoking was estimated by various times in 10 smoking healthy and 30 smoking tuberculosis inpatients compared with 10 non-smoking healthy and 29 non-smoking tuberculosis inpatients, with equal dose of 600 mg rifampin. The concentration of the rifampin was calculated by range matrix analysis area under the curve (Auc.) The Auc0-8 of the healthy and smokers were 75.75 and 110.38 mg.h/L respectively, while in the tuberculosis group, the Auc0-8 of smokers and non-smokers were 30.17 and 43.26 mg h/L respectively. The above figures as compared with the smoking and non-smoking group was decreased by varying degrees in Auc. The difference is significant statistically (P value less than 0.05).
Xie
Z Y
ZY
D000293:Adolescent; D000328:Adult; D006801:Humans; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000097:blood / Q000627:therapeutic use*; D012907:Smoking / Q000009:adverse effects* / Q000097:blood; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000188:drug therapy*
D012293:Rifampin