Synthesis of the nucleopeptides H-Phe-Tyr(pGC)-NH2 and H-Phe-Ser(pGC)-Ala-OH via a phosphotriester approach.
Use of the protecting groups di-n-butylaminomethylene,2-nitrophenylsulfenyl and the ester of 2-(hydroxymethyl)-9,10-anthraquinone, enabled us for the first time to prepare nucleopeptide fragments containing 2'-deoxyguanosine and a free carboxylic acid group.
Kuyl-Yeheskiely
E
E
Gorlaeus Laboratories, Leiden University, The Netherlands.
Dreef-Tromp
C M
CM
Geluk
A
A
van der Marel
G A
GA
van Boom
J H
JH
D055598:Chemical Phenomena; D002621:Chemistry; D003852:Deoxyribonucleoproteins / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009841:Oligonucleotides / Q000138:chemical synthesis*; D009842:Oligopeptides / Q000138:chemical synthesis*
D003852:Deoxyribonucleoproteins; D009841:Oligonucleotides; D009842:Oligopeptides