Near-haploid cell line in megakaryoblastic transformation of Philadelphia-positive chronic myeloid leukemia.
A case of near haploidy in a patient with an acute megakaryoblastic transformation of Philadelphia (Ph)-positive chronic myeloid leukemia (CML) was studied. Cytogenetic studies revealed persistence of a Ph-positive pseudodiploid cell line and the emergence of a Ph-positive near-haploid cell line, i.e., 46,XX,t(9;22)(q34;q11)/28,XX,t(9;22),+8,+14,+18,+29. The near-haploid cell line is a rare cytogenetic finding. The patient rapidly deteriorated and died.
Mayne
K M
KM
John Radcliffe Hospital, Oxford, England.
Maher
E J
EJ
D001752:Blast Crisis / Q000235:genetics* / Q000473:pathology; D005260:Female; D006238:Haploidy; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000473:pathology; D008533:Megakaryocytes / Q000473:pathology* / Q000648:ultrastructure; D008875:Middle Aged