Estrogen and progesterone binding sites in renal cell carcinoma.
Twenty-five renal cell carcinomas were assayed for estrogen and progesterone receptor levels. Estrogen specific binding was present in only 4 patients (16%) and progesterone specific binding in 7 patients (28%). In all cases these receptors were present in very low titers, less than 10 fm/mg. We believe that earlier reports citing significant estrogen and progesterone binding activity may reflect high levels of nonspecific protein binding.
Orovan
W L
WL
Department of Pathology, McMaster University, Hamilton, Ontario, Canada.
Ryan
E D
ED
D000328:Adult; D000368:Aged; D001665:Binding Sites; D002292:Carcinoma, Renal Cell / Q000032:analysis*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone