Pseudohyperaldosteronism due to application of an antihemorrhoid cream.
Three cases of pseudohyperaldosteronism produced by the application of an antihemorrhoid cream containing 9 alpha-fluoroprednisolone are reported. All three presented edema, hypokalemia and metabolic alkalosis. Two of the patients also exhibited slight arterial hypertension. This iatrogenic possibility must be ruled out in cases of hypermineralocorticoidism, thus avoiding unnecessary and costly examinations.
Marin
F
F
Department of Endocrinology, Clinica Puerta de Hierro, Universidad Autónoma, Madrid, Spain.
González Quintela
A
A
Moya
M
M
Suárez
E
E
de Zárraga
M
M
D000287:Administration, Topical; D000328:Adult; D004487:Edema / Q000139:chemically induced; D005260:Female; D005477:Fluprednisolone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use / Q000031:analogs & derivatives; D006484:Hemorrhoids / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D007008:Hypokalemia / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged
C010958:9-fluoroprednisolone; D005477:Fluprednisolone