Cytogenetic study on eleven cutaneous neoplasms and two pre-tumoral lesions from Xeroderma pigmentosum patients.
Eleven independent tumors (5 basa-cell carcinomas, 5 squamous-cell carcinomas and 1 malignant melanoma), 2 pretumoral lesions and one common nevus, developing in the skin of 10 unrelated XP patients were cytogenetically analyzed. No specific chromosomal changes were observed. Two features were relevant, however: emergence of several independent clones and over-involvement of telomeric and centromeric regions in the formation of chromosomal rearrangements. Jumping translocations were observed in 2 squamous-cell carcinomas involving telomeric and centromeric regions.
Aledo
R
R
C.N.R.S. URA 620, Structure et Mutagénèse Chromosomiques, Institut Curie, Paris, France.
Dutrillaux
B
B
Lombard
M
M
Aurias
A
A
D000293:Adolescent; D000328:Adult; D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008297:Male; D011230:Precancerous Conditions / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*; D014983:Xeroderma Pigmentosum / Q000235:genetics*