[Behavior analysis based on neurochemical mechanisms of action of viloxazine and mianserin].
Neuropharmacological study was undertaken on the preparations viloxazine (emovit "Phafmachim" People's Republic of Bulgaria) and mianserin (lerivon "Organon" Holand). Comparative experiments were performed with chlorimipramine ("Spofa", CSSR). The behaviour of mice was evaluated by the test "haloperidol catalepsy" after acute and chronic administration of aforementioned antidepressants. Effects of the preparations were also investigated on the background of hypothermia and stereotypy, induced by apomorphine. The influence of antidepressants after acute and chronic (7 and 14 days) administration was studied on serotonin effect in the central nervous system by examining the influence of the preparations on tics of the head, induced by 5-hydroxytryptophan in mice. An analysis was made on the spectrum of action of the preparations on mediator systems of central nervous system and it was established that after chronic application of mianserin together with its serotoninolytic properties there were effects on adrenergic systems of the central nervous system as well.
Danchev
N
N
Rusakov
D
D
D000818:Animals; D002997:Clomipramine / Q000494:pharmacology; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D051379:Mice; D009025:Morpholines / Q000494:pharmacology*; D009420:Nervous System / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism; D014745:Viloxazine / Q000494:pharmacology*
D009025:Morpholines; D008803:Mianserin; D012701:Serotonin; D014745:Viloxazine; D002997:Clomipramine
Povedencheski analiz vŭrkhu nevrokhimichnite mekhanizmi na deĭstvie na viloksazina i mianserina.