Muscarinic receptor-mediated regulation of OM-853-enhanced dopamine release in striatum of rat.
The effect of OM-853, a new vincamine analogue, on cerebral dopaminergic neurons was investigated in male Wistar rats. The administration of OM-853 (200 mg/kg p.o.) induced facilitation of the metabolic turnover of dopamine (DA) in all brain areas except the cerebral cortex. Addition of OM-853 enhanced the release of [3H]DA from striatal slices; this release was antagonized by atropine (10(-7) M). However, pretreatment with scopolamine (0.5 mg/kg s.c.) inhibited the enhancement of striatal DA turnover induced by OM-853 administration. OM-853 (10(-4) M) inhibited [3H]quinuclidinyl benzilate binding to muscarinic cholinergic receptors in a striatal particulate fraction more potently than carbachol (10(-4) M). These results suggest that OM-853 may induce facilitation of striatal DA turnover by enhancing DA release via the stimulation of muscarinic cholinergic receptor.
Koda
H
H
Department of Pharmacology, Kyoto Prefectural University of Medicine, Japan.
Hashimoto
T
T
Kuriyama
K
K
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000378:metabolism; D001285:Atropine / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D011813:Quinuclidinyl Benzilate; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000187:drug effects*; D012601:Scopolamine / Q000494:pharmacology; D014748:Vinca Alkaloids
D000470:Alkaloids; D011976:Receptors, Muscarinic; D014748:Vinca Alkaloids; D015102:3,4-Dihydroxyphenylacetic Acid; D011813:Quinuclidinyl Benzilate; D001285:Atropine; C038627:vinconate; D002217:Carbachol; D012601:Scopolamine; D001058:Apomorphine; D004298:Dopamine; D006719:Homovanillic Acid