[A radioindicator method of determining the activity of pancreatic lipase in the body].
125I-p-iodophenyllaurate proved to be a suitable substrate of lipase for studies of pancreas lipolytic function in vivo and in vitro. After peroral administration into rats the drug was hydrolyzed by lipase. The liberated 125I-p-iodophenol was absorbed in intestine and excreted with urine either as free 125I-p-iodophenol or its conjugates. Activity of pancreatic lipase was measured on the basis of radioactivity estimation of urine per min.
Kendysh
I N
IN
Brattsev
V A
VA
Klimova
T V
TV
Klimova
A I
AI
D000818:Animals; D007457:Iodine Radioisotopes; D007850:Lauric Acids; D008049:Lipase / Q000032:analysis*; D010179:Pancreas / Q000201:enzymology*; D051381:Rats; D014304:Triolein / Q000652:urine
D007457:Iodine Radioisotopes; D007850:Lauric Acids; C060202:4-iodophenyllaurate; D014304:Triolein; D008049:Lipase
Radioindikatorynyĭ metod opredeleniia aktivnosti pankreaticheskoĭ lipazy v organizme.