title: [Use of crystepin in combination with obsidan in patients with diabetes mellitus with arterial hypertension].
abstract: Examination included 70 patients with diabetes mellitus in combination with arterial hypertension of different origin (II stage essential hypertension and symptomatic renal arterial hypertension). Crystepin (2-3 tablets per 24 h) in combination with beta-adrenoblocker obsidan (40-80 mg/24 h) was used for treatment. Basic hemodynamic parameters and the state of the renin-aldosterone system were determined. The hemodynamic hypotensive effects in these patients due to the influence of the above therapy are uniform and depend on the form of attendant arterial hypertension. The hypotensive effect of crystepin used in combination with obsidan was more pronounced in patients with diabetes and II stage essential hypertension than that in those with diabetes and renal hypertension. The concentration of aldosterone and renin activity of blood plasma in patients with diabetes and arterial hypertension during treatment with crystepin and obsidan had no regular connection with the hemodynamic parameters.
authors.forename: B I
authors.initials: BI
authors.lastname: Leviashvili
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000503:physiopathology; D004232:Diuretics / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D011433:Propranolol / Q000008:administration & dosage*
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D011433:Propranolol
vernacular_title: Primenenie kristepina v sochetanii s obzidanom u bol'nykh sakharnym diabetom s arterial'noĭ gipertenzieĭ.