Adaptation and bursting in neocortical neurones may be controlled by a single fast potassium conductance.
We have used computer simulation of a model neurone and in vitro intracellular recording to demonstrate that the adaptation of repetitive discharge in neocortical neurones can be explained by a fast potassium current whose inactivation is retarded by intracellular calcium. The maximum amplitude of this current determines whether the neurone will discharge in regular or burst mode.
Berman
N J
NJ
MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford.
Bush
P C
PC
Douglas
R J
RJ
D000222:Adaptation, Physiological; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D003198:Computer Simulation; D066298:In Vitro Techniques; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D051381:Rats
D011188:Potassium