title: Molecular characterization of human X/Y translocations suggests their aetiology through aberrant exchange between homologous sequences on Xp and Yq.
abstract: Several DNA sequences from two homologous regions, localized on the distal part of the human X chromosome short arm and on the long arm of the Y chromosome, have been hybridized to DNAs from seven human-rodent hybrids containing human X; Y translocation chromosomes. Molecular characterization of the translocated chromosomes has revealed, in all but one case, transfer of the Y cluster of sequences and complete deletion of the corresponding X-chromosomal sequences. The possible role of X/Y homology in the aetiology of X; Y translocations is proposed.
authors.affiliation: Department of Paediatrics, University of Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ballabio
authors.forename: R
authors.initials: R
authors.lastname: Carrozzo
authors.forename: A
authors.initials: A
authors.lastname: Gil
authors.forename: B
authors.initials: B
authors.lastname: Gillard
authors.forename: N
authors.initials: N
authors.lastname: Affara
authors.forename: M A
authors.initials: MA
authors.lastname: Ferguson-Smith
authors.forename: N
authors.initials: N
authors.lastname: Fraser
authors.forename: I
authors.initials: I
authors.lastname: Craig
authors.forename: M
authors.initials: M
authors.lastname: Rocchi
authors.forename: G
authors.initials: G
authors.lastname: Romeo
mesh_terms: D002460:Cell Line; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D005260:Female; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D009693:Nucleic Acid Hybridization; D012689:Sequence Homology, Nucleic Acid; D014178:Translocation, Genetic; D014960:X Chromosome; D014998:Y Chromosome
chemical_list: D015342:DNA Probes; D004247:DNA