title: [Substances with antibacterial and antifungal activity. VI. Synthesis and microbiologic activity of new derivatives of 1,5-diarylpyrrole and 1,4-pyrrolphenylene].
abstract: New 1,5-diarylpyrrole and 1,4-pyrrolphenylene derivatives were prepared to study influence on the microbiological activity of an unsubstituted pyrrole nucleus or of a double identical molecular structure. Antimicrobial data in comparision with antifungal antibiotic pyrrolnitrin showed that all tested compounds exhibited very poor antifungal and antibacterial activity. Only some derivatives showed a selective activity against strains of Candida sp. and against strains of gram-positive or gram-negative bacteria.
authors.forename: G C
authors.initials: GC
authors.lastname: Porretta
authors.forename: F
authors.initials: F
authors.lastname: Cerreto
authors.forename: F
authors.initials: F
authors.lastname: Fioravanti
authors.forename: M
authors.initials: M
authors.lastname: Biava
authors.forename: M
authors.initials: M
authors.lastname: Scalzo
authors.forename: M
authors.initials: M
authors.lastname: Fischetti
authors.forename: F
authors.initials: F
authors.lastname: Riccardi
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D001555:Benzene Derivatives; D011758:Pyrroles
vernacular_title: Richerche su sostanze ad attività antibatterica ed antifungina. Nota VI--Sintesi ed attività microbiologica di nuovi derivati dell'1,5-diarilpirrolo ed 1,4-pirrolfenilene.