title: The stepwise biphotonic photoionization of chlorpromazine as seen by laser flash photolysis.
abstract: It is generally accepted that both promazine (PZ) and chlorpromazine (CPZ) photionize monophotonically to their respective cation radicals and the corresponding hydrated electrons. It is also supposed that this photoinization has a role in the phototoxic effects of these drugs. However, using laser flash photolysis, we have observed that photoionization of CPZ during S1 excitation (lambda greater than 300 nm) is a stepwise biphotonic process. In the case of PZ our flash photolysis results are less clearcut, but are consistent with stepwise biphotonic photoionization for S1 excitation. We demonstrate, using computer simulation of the intramolecular kinetics, that the estimated triplet state lifetime of CPZ is sufficiently long (23 ns at room temperature) to account for the apparent monophotonic photoionization that has been observed by others at high light intensities and short pulse times. Our laser flash photolysis results also suggest that the photo-ionization mechanism of PZ and CPZ is wavelength-dependent. Both drugs exhibit apparent monophotonic photoionization when they are excited at 266 nm under conditions of laser pulse width and intensity similar to those at 355 nm. We suggest that photoionization is not an important mechanism in the observed phototoxic and photoallergic effects of PZ and CPZ in sunlight.
authors.forename: G R
authors.initials: GR
authors.lastname: Buettner
authors.forename: R D
authors.initials: RD
authors.lastname: Hall
authors.forename: C F
authors.initials: CF
authors.lastname: Chignell
authors.forename: A G
authors.initials: AG
authors.lastname: Motten
mesh_terms: D002746:Chlorpromazine; D003198:Computer Simulation; D007700:Kinetics; D007834:Lasers; D010782:Photolysis; D011395:Promazine
chemical_list: D011395:Promazine; D002746:Chlorpromazine