title: [A case of malignant transformation of gastric hyperplastic polyp with metaplastic bone formation].
abstract: A case of malignant transformation of a gastric hyperplastic polyp with a metaplastic bone formation is reported. A large gastric polyp was revealed by X-ray examination and by endoscopy in the cardia of a 89-year-old female who had complained of nausea. A polypectomy was performed since the biopsied materials had contained some atypical glands intermingled with hyperplastic glands. Histologically, the polyp, 1.7 x 1.0 x 0.6 cm in size, was a hyperplasic polyp that was found to contain superficial dysplastic foci associated with a moderately differentiated type of a tubular adenocarcinoma. A metaplasic bone formation was found in stroma beneath the hyperplastic glandular epithelium. Thus, polypectomy of hyperplastic polyps of the stomach of more than 1 cm with dysplastic foci is recommended.
authors.affiliation: 2nd Dept. of Pathology, Kochi Medical School.
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuki
authors.forename: H
authors.initials: H
authors.lastname: Sonobe
authors.forename: T
authors.initials: T
authors.lastname: Hikita
authors.forename: J
authors.initials: J
authors.lastname: Iwata
authors.forename: M
authors.initials: M
authors.lastname: Furihata
authors.forename: T
authors.initials: T
authors.lastname: Mizobuchi
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D001842:Bone and Bones / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008679:Metaplasia; D011127:Polyps / Q000473:pathology*; D013270:Stomach / Q000473:pathology*