title: Biosynthesis of benanomicins.
abstract: The biosynthesis of benanomicins A and B, produced by actinomycete strain MH193-16F4, was investigated by feeding experiments with 14C- and 13C-labeled compounds followed by measurement of radioactivity and 13C NMR analysis. A 2D double quantum coherence NMR spectrum of benanomicin A derived from sodium [1,2-13C2]acetate provided the location of intact acetate units, and confirmed the 13C assignments of benanomicins. The results indicate that the aglycone of benanomicins is derived from a dodecaketide, methionine and alanine.
authors.affiliation: Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Gomi
authors.forename: M
authors.initials: M
authors.lastname: Sezaki
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: S
authors.initials: S
authors.lastname: Kondo
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000192:Actinomycetales / Q000378:metabolism*; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D000935:Antifungal Agents / Q000096:biosynthesis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D000095643:Pradimicins and Benanomicins
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; C056805:benanomicin A; D000095643:Pradimicins and Benanomicins; C056806:benanomicin B