[Absorption, distribution, metabolism and excretion of N-cyclohexyl-2-benzothiazyl sulfenamide (CBS), a vulcanizing accelerator, in rats].
Absorption, distribution, metabolism and excretion were studied in rats following a single oral administration of N-cyclohexyl-2-benzothiazyl sulfenamide (CBS) at a dose of 250 mg/kg. About 65% and 24% of the dose were excreted into urine and feces, respectively, for 3 days after administration of labeled CBS (cyclohexyl-14C). Biliary excretion amounted to about 5% of the dose for 3 days. While about 92% of the dose was recovered in urine and feces at a ratio of 1:1 within 3 days when 14C-2CBS was given. No specific organ-affinity was observed in distribution study. Cyclohexylamine and 2-mercaptobenzothiazole were identified as urinary metabolites.
Adachi
T
T
Division of Medical Chemistry, National Institute of Hygienic Sciences, Tokyo, Japan.
Tanaka
A
A
Yamaha
T
T
D000284:Administration, Oral; D000818:Animals; D052160:Benzothiazoles; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012408:Rubber; D013844:Thiazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D052160:Benzothiazoles; D013844:Thiazoles; D012408:Rubber; C044169:thiohexam