title: Accumulation of ceramide in ischemic human brain of an acute case of cerebral occlusion.
abstract: An increase of ceramide, which is the major component of sphingolipids, was found in the ischemic human brain of an acute case of internal carotid artery occlusion. Amide-linked fatty acids in the ceramide isolated from the ischemic human brain were mostly non-hydroxy fatty acids, such as stearic acid (66.9%) and palmitic acid (20.2%). Other long-chain fatty acids, C24:0 and C21:1, were rare components in the ceramide. The ceramide contained C-20 sphingosine, and the ratio of C-20 to C-18 was 0.13. These findings indicate that an ischemic insult accelerates the degradation of gangliosides and causes an accumulation of ceramide in the ischemic human brain.
authors.affiliation: Department of Neurosurgery, Fuchu Metropolitan Hospital, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kubota
authors.forename: S
authors.initials: S
authors.lastname: Kitahara
authors.forename: H
authors.initials: H
authors.lastname: Shimasaki
authors.forename: N
authors.initials: N
authors.lastname: Ueta
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology; D002340:Carotid Artery Diseases / Q000378:metabolism*; D002343:Carotid Artery, Internal; D002518:Ceramides / Q000009:adverse effects / Q000378:metabolism*; D002554:Cerebrosides / Q000378:metabolism; D005260:Female; D006801:Humans; D013109:Sphingomyelins / Q000378:metabolism
chemical_list: D002518:Ceramides; D002554:Cerebrosides; D013109:Sphingomyelins