Enhancement of oral bioavailability of d-alpha-tocopherol acetate by lecithin-dispersed aqueous preparation containing medium-chain triglycerides in rats.
In order to evaluate oral dosage forms of d-alpha-tocopherol acetate (VEA), d-alpha-tocopherol (VE) concentration in the plasma was examined following oral administration of three VEA preparations; lecithin-dispersed aqueous preparation, polysorbate 80 (PS-80)-solubilized aqueous solution and soybean oil solution. The lecithin-dispersed preparation gave the highest Cmax and the largest AUC0-24h, while Tmax was delayed. In the thoracic duct fistula rat, no increase in VE plasma concentration was observed after intraduodenal administration of lecithin-dispersed VEA preparation via the lymphatic route. The delayed Tmax and prolonged VE plasma concentration obtained with the lecithin-dispersed preparation in comparison with PS-80-solubilized aqueous solution could be explained by the different route of absorption.
Kimura
T
T
Fukui
E
E
Kageyu
A
A
Kurohara
H
H
Kurosaki
Y
Y
Nakayama
T
T
Morita
Y
Y
Shibusawa
K
K
Ohsawa
S
S
Takeda
Y
Y
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D005079:Excipients; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000494:pharmacology*; D014810:Vitamin E / Q000493:pharmacokinetics*
D005079:Excipients; D010713:Phosphatidylcholines; D014280:Triglycerides; D014810:Vitamin E