Hindering of tumor lung metastasizing with alpha-(4-cyclohexylphenyl)propionic acid in mice.
Alpha-(4-cyclohexylphenyl)propionic acid, a potent inhibitor of platelet aggregation, has appeared to reduce the quantity and size of Lewis lung carcinoma (LLC) tumor nodules in the lungs. The number of animals developing the tumor colonies in the lungs was decreased by 34% to 49% either when the tumor cells were injected i.v. and alpha-(4-cyclohexylphenyl)propionic acid was administered during 3 days, or when the tumor cells were transplanted i.m. The primary tumor was removed 6 days later and the drug administered during 8 or 21 days.
Mamytbeková
A
A
Research Institute for Pharmacy and Biochemistry, Prague, Czechoslovakia.
Cepelák
V
V
Grimová
J
J
Rezábek
K
K
Kuchar
M
M
D000818:Animals; D000970:Antineoplastic Agents; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D006614:Hindlimb; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000517:prevention & control / Q000556:secondary; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D010666:Phenylpropionates / Q000627:therapeutic use*; D013623:Tail / Q000098:blood supply
D000970:Antineoplastic Agents; D010666:Phenylpropionates; C006250:hexaprofen