Trans-cranial electrical stimulation attenuates the severity of naloxone-precipitated morphine withdrawal in rats.
The expression of morphine withdrawal in rats has been demonstrated as dependent upon the integrity of specific brain regions. Focal intracranial electrical stimulation of some of these sites results in the attenuation of withdrawal severity. The present study demonstrates that electrical auricular stimulation, in a paradigm known to attenuate nociceptive responses of several brain nuclei, attenuates the severity of naloxone-precipitated morphine withdrawal in rats. This simple non-invasive treatment, based on long-standing principles of electroacupuncture, may provide a useful adjunct for therapy of the narcotic withdrawal syndrome.
Dougherty
P M
PM
University of Texas Medical School, Department of Neurobiology and Anatomy, Houston 77225.
Dafny
N
N
D000818:Animals; D001921:Brain / Q000503:physiopathology*; D004558:Electric Stimulation; D008297:Male; D009020:Morphine; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology* / Q000628:therapy; D019966:Substance-Related Disorders / Q000503:physiopathology*
D009270:Naloxone; D009020:Morphine