[Effect of feeding a small-peptide elemental diet on amino acid absorption and its mechanism--study by measuring the transmural potential difference in guinea-pig small intestine].
The effect of feeding a small-peptide elemental diet on brush border membrane aminopeptidase activities and amino acid absorption in guinea-pigs was investigated. The latter effect and its mechanism were studied by measuring the transmural potential difference. Aminopeptidase activities on brush border membrane were significantly higher in the group fed a small-peptide elemental diet (SP group) than in the group fed an amino acids elemental diet (AA group). In the SP group, the absorption of both glycyl-L-leucine and L-leucine was greater than that in the AA group. The increase of delta PDmax of L-leucine in the SP group indicated that the acceleration of mucosal uptake of an amino acid in the SP group was due to an increased number of carriers.
Fuse
K
K
Bamba
T
T
Sasaki
M
M
Hosoda
S
S
D000596:Amino Acids / Q000378:metabolism*; D000626:Aminopeptidases / Q000378:metabolism; D000818:Animals; D004151:Dipeptides / Q000008:administration & dosage* / Q000378:metabolism; D004594:Electrophysiology; D005526:Food, Formulated; D006168:Guinea Pigs; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000502:physiology*; D008297:Male; D008871:Microvilli / Q000201:enzymology
D000596:Amino Acids; D004151:Dipeptides; D000626:Aminopeptidases