title: Degradation of porcine brain natriuretic peptide (pBNP-26) by endoprotease-24.11 from kidney cortical membranes.
abstract: Porcine brain natriuretic peptide of 26 amino acid residues (pBNP-26) is inactivated by endoprotease-24.11 (EC 3.4.24.11) of kidney cortical membranes. In contrast to human alpha atrial natriuretic peptide/cardiodilatin (ANP/CDD) showing a single major cleavage within the disulfide-linked loop between Cys and Phe in position 7 and 8, pBNP-26 is cleaved at several sites. Although both pBNP-26 and ANP/CDD exhibit Cys-Phe peptide bonds at the corresponding positions this bond is not cleaved in BNP-26.
authors.affiliation: Institut für Anatomie und Zellbiologie III, Universität Heidelberg, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Vogt-Schaden
authors.forename: M
authors.initials: M
authors.lastname: Gagelmann
authors.forename: D
authors.initials: D
authors.lastname: Hock
authors.forename: F
authors.initials: F
authors.lastname: Herbst
authors.forename: W G
authors.initials: WG
authors.lastname: Forssmann
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D004285:Dogs; D007672:Kidney Cortex / Q000201:enzymology*; D007700:Kinetics; D008969:Molecular Sequence Data; D020097:Natriuretic Peptide, Brain; D015260:Neprilysin / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D013379:Substrate Specificity; D013552:Swine
chemical_list: D009419:Nerve Tissue Proteins; D020097:Natriuretic Peptide, Brain; D015260:Neprilysin