title: A study of tolerance to the psychomotor effects of indomethacin in healthy volunteers.
abstract: We have examined the effect of single dose indomethacin 50 mg on objective measurements of psychomotor function and whether this effect is altered by pretreatment with indomethacin 25 mg t.i.d. for 7 days in 10 healthy volunteers (5 male, 5 female; age 20-54 y). One hour after a single dose of indomethacin 50 mg there was significant impairment of psychomotor function (critical flicker fusion frequency threshold and choice reaction time) (Wilcoxon p less than 0.05). Pretreatment with indomethacin 25 mg t.i.d. for 7 days prevented this impairment. Thus we conclude that tolerance occurs over the course of a week to the psychomotor effects of indomethacin.
authors.affiliation: Department of Medicine, University of Leeds.
authors.forename: T
authors.initials: T
authors.lastname: Pullar
authors.forename: S
authors.initials: S
authors.lastname: Dale
authors.forename: J
authors.initials: J
authors.lastname: Lowe
authors.forename: H
authors.initials: H
authors.lastname: Bird
mesh_terms: D000328:Adult; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D005260:Female; D005425:Flicker Fusion / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects
chemical_list: D007213:Indomethacin