Cardiovascular effects of morphine during hypothermia.
The cardiovascular effects of morphine were determined in anesthetized dogs at 37 and 30 degrees C. Intravenous (i.v., 1 mg/kg) but not intracisternal (i.c., 0.1 mg/kg) morphine produced a significant cardiovascular depression only at 30 degrees C. These effects were antagonized by i.v. naloxone (1 mg/kg) suggesting a peripherally mediated opiate mechanism. Moreover, hypothermia significantly increased plasma and cerebrospinal fluid morphine levels and enhanced the morphine-induced histamine release. The results suggest that opiates could have detrimental effects in patients with poor cardiovascular reserve in which high doses of opiates and hypothermia may be used concomitantly.
Alcaraz
C
C
Department of Anesthesiology, NYU Medical Center, NY 10016.
Bansinath
M
M
Turndorf
H
H
Puig
M M
MM
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002946:Cisterna Magna; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006632:Histamine / Q000097:blood; D007035:Hypothermia / Q000503:physiopathology*; D007267:Injections; D007275:Injections, Intravenous; D008297:Male; D009020:Morphine / Q000097:blood / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D011863:Radioimmunoassay; D013997:Time Factors
D009270:Naloxone; D009020:Morphine; D006632:Histamine