title: [Erythema action spectrum in xeroderma pigmentosum group A patients].
abstract: Twenty patients with xeroderma pigmentosum group A (XP-A) and 30 healthy controls were studied to determine the energy requirements for UV-erythema with monochromatic light between 255 and 340 nm. As test sites, unexposed skin on the upper back was selected for irradiation using a prism monochromator and a 1 kW xenon arc source. The minimal erythema doses (MEDs) were determined at each erythemal response peak, at 24 hours post irradiation in normal controls and at 72 hours in XP-A patients, respectively. Compared with normal subjects, XP-A patients had extremely low MEDs at all wavelengths tested. The erythema action spectrum showed 2 peaks at 265 and 290 nm in XP-A patients and the greatest effectiveness at 290 nm. These results indicate that XP-A patients should be protected strongly against not only UVB but also UVA, because the photo-hypersensitivity in XP-A patients has been extended from the UVB to UVA region.
authors.forename: Y
authors.initials: Y
authors.lastname: Mitoh
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004307:Dose-Response Relationship, Radiation; D004890:Erythema / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012878:Skin Neoplasms / Q000150:complications*; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014983:Xeroderma Pigmentosum / Q000150:complications*