title: Propranolol metabolism by Cunninghamella bainieri.
abstract: 1. Incubations of racemic propranolol alone or in the presence of either quinidine or sparteine were performed with Cunninghamella bainieri. 2. Five mammalian metabolites of propranolol (4-hydroxypropranolol, desisopropyl-propranolol, 1-naphthoxylactic acid, propranolol glycol and 1-naphthoxyacetic acid) were present in unhydrolysed extracts of the incubation medium according to h.p.l.c. and g.l.c. analyses. The relative proportion of 4-hydroxypropranolol increased after enzymic treatment. 3. Propranolol not only had a fungistatic effect, but also caused morphological changes in the organism, which were accompanied by decomposition of 4-hydroxypropranolol and formation of a greenish-brown colour in the incubation medium. 4. Drug interaction experiments yielded results which paralleled those reported in mammals. 5. The findings indicate that C. bainieri may be a useful microbial model for drug disposition and interaction studies.
authors.affiliation: Bureau of Drug Research, Sir Frederick Banting Research Centre, Ottawa, Ontario, Canada.
authors.forename: B C
authors.initials: BC
authors.lastname: Foster
authors.forename: H S
authors.initials: HS
authors.lastname: Buttar
authors.forename: S A
authors.initials: SA
authors.lastname: Qureshi
authors.forename: I J
authors.initials: IJ
authors.lastname: McGilveray
mesh_terms: D001711:Biotransformation; D004347:Drug Interactions; D009090:Mucorales / Q000378:metabolism*; D011433:Propranolol / Q000378:metabolism* / Q000493:pharmacokinetics; D011802:Quinidine / Q000378:metabolism; D013034:Sparteine / Q000378:metabolism
chemical_list: D013034:Sparteine; D011433:Propranolol; D011802:Quinidine