Preventive effect of MK-733 (simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits.
MK-733 was found to prevent an increase of serum cholesterol levels in cholesterol-fed rabbits, and lovastatin also markedly inhibited their increase. MK-733 and lovastatin inhibited the increase of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) cholesterol, and it slightly affected the high density lipoprotein (HDL) cholesterol levels. MK-733 and lovastatin suppressed the increase of serum phospholipid levels and slightly affected the triglyceride levels. MK-733 suppressed the development of atherosclerosis in coronary arteries and aorta, and lovastatin also diminished their development.
Kobayashi
M
M
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
Ishida
F
F
Takahashi
T
T
Taguchi
K
K
Watanabe
K
K
Ohmura
I
I
Kamei
T
T
D000818:Animals; D001011:Aorta / Q000032:analysis / Q000473:pathology; D001161:Arteriosclerosis / Q000517:prevention & control*; D002784:Cholesterol / Q000032:analysis; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D006937:Hypercholesterolemia / Q000517:prevention & control*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000032:analysis; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009206:Myocardium / Q000473:pathology; D011817:Rabbits; D019821:Simvastatin
D002791:Cholesterol, Dietary; D008055:Lipids; D002784:Cholesterol; D008148:Lovastatin; D019821:Simvastatin