Studies on new phosphate ester antifungal antibiotics phoslactomycins. II. Structure elucidation of phoslactomycins A to F.
Phoslactomycins A to F are new antifungal antibiotics produced by Streptomyces nigrescens SC-273. On the basis of physico-chemical properties and NMR studies, their structures have been determined as shown in Fig. 6. They are characterized by possessing alpha, beta-unsaturated delta-lactone, phosphate ester, conjugated diene and cyclohexane ring moieties. The structural difference between them is ascribed to a substituent bound to the cyclohexane ring.
Fushimi
S
S
Institute of Applied Microbiology, University of Tokyo, Japan.
Furihata
K
K
Seto
H
H
D000935:Antifungal Agents / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D006868:Hydrolysis; D007783:Lactones / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D011753:Pyrones; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism
D000935:Antifungal Agents; D007783:Lactones; D009943:Organophosphorus Compounds; D011753:Pyrones; C060448:phoslactomycin A; C060449:phoslactomycin B; C060450:phoslactomycin C; C060451:phoslactomycin D; C060452:phoslactomycin E; C060453:phoslactomycin F