Widespread quinolone resistance among methicillin-resistant Staphylococcus aureus isolates in a general hospital.
Ofloxacin and ciprofloxacin resistance (MIC, greater than 4 micrograms/ml) was encountered in 45 of 50 clinical isolates of methicillin-resistant Staphylococcus aureus. None of 20 methicillin-susceptible strains was resistant to the quinolones (P less than 10(-6). Quinolone-susceptible and -resistant isolates did not differ with respect to culture source or bacteriophage type. The future usefulness of quinolones for S. aureus infection may be limited.
Shalit
I
I
Department of Infectious Diseases, Tel-Aviv Medical Center, Israel.
Berger
S A
SA
Gorea
A
A
Frimerman
H
H
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006801:Humans; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*
D042462:4-Quinolones; D000890:Anti-Infective Agents; D008712:Methicillin