[The dose-dependent action of naloxone on systemic and portal circulation in acute blood loss in rats].
Using the method of contact luminescent biomicroscopy of the liver and the intestine coupled with the ultrasonic measurement of systemic blood pressure, blood flow velocity in the portal vein and hepatic artery it has been established that in rats with acute decompensatory hemorrhage naloxone increases blood pressure and improves the state of protal macro and microcirculation only after i. v. injection of large dose (5 mg/kg). Naloxone does not influence the dynamics of acute compensatory hemorrhage and the development of the posthemorrhagic microcirculatory disturbances (local microstases, microthromboses, erythrocyte aggregation).
Kovalenko
N Ia
NIa
Matsievskiĭ
D D
DD
D000208:Acute Disease; D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006470:Hemorrhage / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009270:Naloxone / Q000008:administration & dosage*; D011168:Portal System / Q000187:drug effects* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains
D009270:Naloxone
Dozozavisimoe deĭstvie naloksona na sistemnoe i portal'noe krovoobrashchenie pri ostroĭ krovopotere u krys.