title: Identification and significance of multinucleate tumor cells in retinoblastoma.
abstract: Multinucleate tumor cells were observed in a case of a retinal tumor suspected to be a retinoma (retinocytoma). On electron microscopy, these cells had characteristics of retinoblastoma. Similar cells were observed in an irradiated model of retinoblastoma grown in a nude mouse. We suggest that the presence of these cells indicates differentiation and/or regression of the tumor.
authors.affiliation: David G. Cogan Eye Pathology Laboratory, Harvard Medical School, Boston, MA.
authors.forename: M A
authors.initials: MA
authors.lastname: Howard
authors.forename: T P
authors.initials: TP
authors.lastname: Dryja
authors.forename: D S
authors.initials: DS
authors.lastname: Walton
authors.forename: D M
authors.initials: DM
authors.lastname: Albert
mesh_terms: D000818:Animals; D002114:Calcinosis; D002467:Cell Nucleus / Q000648:ultrastructure*; D002471:Cell Transformation, Neoplastic; D002675:Child, Preschool; D003593:Cytoplasm / Q000648:ultrastructure; D005134:Eye Neoplasms / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009336:Necrosis; D009368:Neoplasm Transplantation; D015388:Organelles / Q000648:ultrastructure; D012175:Retinoblastoma / Q000648:ultrastructure*; D012878:Skin Neoplasms / Q000648:ultrastructure