Lithium alters the stereoselectivity of monoamine oxidase in rat brain.
The effects of lithium on monoamine oxidase (MAO) in rat brain were studied in the presence of each enantiomer of tranylcypromine [(+)- and (-)-TCP]. The (+)-enantiomer was 25 times more potent than its antipode as MAO inhibitor. Lithium enhanced the inhibitory effect of (-)-TCP on MAO, but it did not affect actions of the (+)-enantiomer. Moreover, lithium influenced the stereoselective index for MAO, which suggests that lithium altered conformational features of the enzyme.
Smith
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Aarhus University Institute of Psychiatry, Psychiatric Hospital, Risskov, Denmark.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D014191:Tranylcypromine / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D014191:Tranylcypromine; D008094:Lithium; D008995:Monoamine Oxidase