title: Regional left ventricular filling: does it reflect diastolic abnormalities in contiguous areas of myocardium?
abstract: To test the hypothesis that regional left ventricular filling reflects diastolic changes in contiguous areas of myocardium, we performed radionuclide ventriculograms on normal subjects, patients with left anterior descending coronary artery disease, and patients with anteroseptal myocardial infarctions. We reasoned that because diastolic properties of the anteroseptal myocardium should be different in the three groups of patients, regional filling in the anteroseptal area of the left ventricle should also be different, if regional filling does, indeed, reflect diastolic changes in the adjacent myocardium. While anteroseptal regional filling in the normal subjects was different than regional filling in the two patient groups, the degree of filling abnormality was similar in patients with and without myocardial infarctions. Our results suggest that regional left ventricular filling is not exclusively determined by diastolic changes in contiguous areas of myocardium.
authors.affiliation: Department of Medicine, State University of New York Health Sciences Center, Stony Brook 11794.
authors.forename: E J
authors.initials: EJ
authors.lastname: Brown
authors.forename: J
authors.initials: J
authors.lastname: Idoine
authors.forename: R D
authors.initials: RD
authors.lastname: Swinford
authors.forename: W M
authors.initials: WM
authors.lastname: Pollack
authors.forename: W E
authors.initials: WE
authors.lastname: Lawson
authors.forename: B
authors.initials: B
authors.lastname: Shatkin
authors.forename: Z H
authors.initials: ZH
authors.lastname: Oster
authors.forename: H L
authors.initials: HL
authors.lastname: Atkins
authors.forename: P F
authors.initials: PF
authors.lastname: Cohn
mesh_terms: D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology; D003971:Diastole; D004912:Erythrocytes; D005260:Female; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology; D011877:Radionuclide Imaging; D012016:Reference Values; D013667:Technetium
chemical_list: D013667:Technetium