[Autotransplantation of parathyroid glands in thyroid carcinoma surgery and their postoperative function].
Total removal and subsequent autotransplantation of parathyroid glands were carried out in operations for thyroid carcinoma in 25 cases. For the purpose of fine dissection of paratracheal lymph nodes, before thyroidectomy more than 2 parathyroid glands were found and transplanted into greater pectoralis muscle. The patients who underwent surgery were studied for more than one year following operation to determine the short term and long term outcomes of the procedure. None of the patients received prophylactic calcium supplement therapy except for hypocalcemic symptoms. In thirteen patients, the parathyroid function was almost completely restored within 3 weeks without any postoperative substitution therapy, with an obvious surge in the plasma PTH level on 5P.O.D. The serum Ca level started to elevate on 7P.O.D. and recovered to 97.4% of the preoperative value 3 weeks after transplantation. As for the 12 patients who exhibited hypocalcemic symptoms, Ca lactate and hydroxycholecalciferol were administered for only 24.7 and 17.0 days, respectively. Serum levels of Ca and P, as well as the index of bone mineral content, were all within the extremely excellent range even one year after operation. None of the patients was on a substitution regimen. These results suggest that autotransplantation is a valuable alternative for the preservation of the parathyroid function in operations for thyroid carcinoma.
Takeuchi
M
M
Second Department of Surgery, Nagoya University School of Medicine, Japan.
Funahashi
H
H
Sato
Y
Y
Imai
T
T
Nozaki
H
H
Mizuno
S
S
Takagi
H
H
D000328:Adult; D002118:Calcium / Q000097:blood; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D006996:Hypocalcemia / Q000188:drug therapy / Q000209:etiology; D007773:Lactates / Q000627:therapeutic use; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000503:physiopathology / Q000637:transplantation*; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D011183:Postoperative Complications / Q000188:drug therapy; D011184:Postoperative Period; D013964:Thyroid Neoplasms / Q000601:surgery*; D013965:Thyroidectomy; D014182:Transplantation, Autologous
D006887:Hydroxycholecalciferols; D007773:Lactates; D010281:Parathyroid Hormone; D010758:Phosphorus; D019344:Lactic Acid; D002118:Calcium