Safety and tolerance of ocular administration of recombinant alpha interferon.
The safety, tolerance, and levels of drug in the nasal cavity produced by an ocular formulation of interferon were determined at four dosages in a placebo-controlled, double-masked trial. Interferon given by the ocular route was generally well tolerated, although a dose-related occurrence of subjective symptoms was detected.
Turner
R B
RB
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84132.
Durcan
F J
FJ
Albrecht
J K
JK
Crandall
A S
AS
D000328:Adult; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D009297:Nasal Mucosa / Q000378:metabolism; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins
D007370:Interferon Type I; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins