Comparison of the dissolution behaviour of tablets containing the drug in a polyethyleneglycol solid dispersion with direct compressed tablets.
Higher dissolution rates of diazepam were noted with tablets containing the drug in polyethyleneglycol solid dispersion compared to these containing a physical mixture of the drug granulated with polyethyleneglycol or to directly compressed tablets. The shape factor and t63% depend strongly on the method of incorporation of the drug in the compressed mass. The dissolution of the drug becomes pH independent when it is present as a solid dispersion, which may be advantageous for the bioavailability.
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D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D011092:Polyethylene Glycols; D012995:Solubility; D013607:Tablets
D013607:Tablets; D011092:Polyethylene Glycols