title: Increasing methotrexate effect with increasing dose in the treatment of resistant rheumatoid arthritis.
abstract: Forty-six patients with recalcitrant rheumatoid arthritis entered a trial encompassing a 2-week inpatient period plus a 16-week, randomized double blind, parallel study comparing placebo, 5 mg/m2 and 10 mg/m2 oral weekly methotrexate (MTX). An additional 6 patients, given 20 mg/m2 MTX, contributed to the toxicity, but not the efficacy analysis. All patients had "failed" either gold or D-penicillamine. A linear dose response relationship (placebo vs 5 mg/m2 vs 10 mg/m2) was found for 5 of 11 outcome variables: patient pain and patient global scale, physician global scale, joint tenderness count and activity of daily living scale (p less than 0.05 for each). Gastrointestinal toxicity (p = 0.002), dyspepsia (p less than 0.03) and stomatitis (p less than 0.09) occurred more commonly with MTX, and a general trend, although not significant, was found toward a dose toxicity relationship.
authors.affiliation: University of Iowa Hospitals and Clinics, Iowa City.
authors.forename: D E
authors.initials: DE
authors.lastname: Furst
authors.forename: R
authors.initials: R
authors.lastname: Koehnke
authors.forename: L F
authors.initials: LF
authors.lastname: Burmeister
authors.forename: J
authors.initials: J
authors.lastname: Kohler
authors.forename: I
authors.initials: I
authors.lastname: Cargill
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000534:rehabilitation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D008875:Middle Aged; D026741:Physical Therapy Modalities; D011897:Random Allocation
chemical_list: D008727:Methotrexate