title: Ciprofloxacin concentrations in serum, bone and bone marrow of rabbits.
abstract: Ciprofloxacin concentrations were determined in serum, bone and bone marrow of rabbits. Four experimental groups of animals were examined: group A (n = 6) received a dosage of 60 mg/kg/day intramuscularly for 4 weeks, groups B (n = 6), C (n = 15) and D (n = 15) received dosages of 120 mg/kg/day subcutaneously for 2 days, 2 weeks, and 4 weeks, respectively. In the kinetic portion of the study, peak serum concentrations of ciprofloxacin measured at the 15 min sampling time were: 2.61 +/- 0.27 micrograms/ml in the 60 mg/kg/day group (group A) and 3.24 +/- 0.78 micrograms/ml in the 120 mg/kg/day group (group B). At necropsy, rabbits in group A had mean ciprofloxacin concentrations of 3.60 +/- 2.27 micrograms/ml in serum, 2.24 +/- 1.19 micrograms/g in marrow and 1.19 +/- 0.44 micrograms/g in bone. Rabbits in group B achieved mean levels of 4.02 +/- 1.23 micrograms/ml in serum, 2.48 +/- 0.79 micrograms/g in marrow, and 1.35 +/- 0.40 micrograms/g in bone. Rabbits in group C achieved mean levels of 5.65 +/- 2.16 micrograms/ml in serum, 3.74 +/- 1.33 micrograms/g in marrow and 1.92 +/- 0.94 micrograms/g in bone. Rabbits in group D achieved mean levels of 7.24 +/- 2.50 micrograms/ml in serum, 4.48 +/- 1.68 micrograms/g in marrow, and 1.93 +/- 0.54 micrograms/g in bone. Differences between mean values for the four experimental groups were not statistically significant.
authors.affiliation: Department of Microbiology, Quillen-Dishner College of Medicine, East Tennessee State University, Johnson City 37614.
authors.forename: L R
authors.initials: LR
authors.lastname: Gill
authors.forename: K J
authors.initials: KJ
authors.lastname: Mayberry-Carson
authors.forename: B
authors.initials: B
authors.lastname: Tober-Meyer
authors.forename: F
authors.initials: F
authors.lastname: Hodin
authors.forename: D W
authors.initials: DW
authors.lastname: Lambe
authors.forename: B G
authors.initials: BG
authors.lastname: Painter
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D008297:Male; D011817:Rabbits; D012044:Regression Analysis
chemical_list: D002939:Ciprofloxacin