[Clinico-pharmacologic study on the liquid form of nifedipine in treating hypertensive crisis].
33 patients with hypertensive crisis were treated with a 2% Nifedipine solution for oral use. 5 patients had taken 5 mg, 16 patients--10 mg and 12 patients--20 mg of the drug. The antihypertensive action was followed up to the 6-th hour. The results show that the antihypertensive action of Nifedipine in doses of 5, 10 and 20 mg begins on the 5-th minute. The maximum antihypertensive action of these three doses is manifested between the 15 and 30 min. The duration of Nifedipine action in a dose of 5 mg is up to the 2-d hour and that of 10 and 20 mg doses is up to the 6-th hour. Only the 20 mg dose leads to a transitory statistically significant increase of the pulse rate with 10-12(-1) (p less than 0.05) between the 15 and 30 min. The side effects of the three doses are insignificant.
Popiliev
I
I
Angelova
I
I
Dzhoneva
S
S
Khodzheva
D
D
D000284:Administration, Oral; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D012996:Solutions; D013997:Time Factors
D012996:Solutions; D009543:Nifedipine
Kliniko-farmakologichno izsledvane na techna forma nifedipin pri lechenieto na khipertonichni krizi.