[Mechanisms of activation and the role of lipid peroxidation in exacerbation of chronic pancreatitis].
It is indicated that in patients with chronic pancreatitis, lipid peroxidation is activated during disease exacerbation and is reduced in the course of the clinical recovery. Activation of lipid peroxidation is associated with the increasing functional activity of neutrophils stimulated in turn by high trypsin content in blood. In the authors' opinion, such a closed mechanism (trypsin-functional activity of neutrophils-lipid peroxidation-trypsin) determines the maintenance of chronic pancreatitis exacerbation. The therapeutic recommendations are provided.
Zhukov
N A
NA
Zhukova
E N
EN
Klimova
S K
SK
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004789:Enzyme Activation; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D015227:Lipid Peroxidation; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D010087:Oxides / Q000097:blood; D010195:Pancreatitis / Q000378:metabolism*; D014357:Trypsin / Q000097:blood
D005609:Free Radicals; D010087:Oxides; D006861:Hydrogen Peroxide; D014357:Trypsin
Mekhanizmy aktivatsii i rol' perekisnogo okisleniia lipidov pri obostrenii khronicheskogo pankreatita.