title: Distribution and metabolism of 1,2,4-trimethylbenzene (pseudocumene) in the rat.
abstract: 1. Single doses of 1,2,4-trimethylbenzene (124TMB) or 14C-124TMB were administered orally to rats for metabolism and distribution studies. 2. 14C-124TMB was rapidly and widely distributed throughout the body with the highest levels in adipose tissue. No other preferential uptake of 14C-124TMB by any of the organs or tissues examined was evident. 3. Tissue levels declined rapidly within 24 h after dosage, with more than 99% of the administered radioactivity recovered in the urine during this period. 4. A complex mixture of isomeric trimethylphenols, dimethylbenzyl alcohols, dimethylbenzoic acids and dimethylhippuric acids excreted in the urine accounted for more than 81% of the administered dose. The major metabolites were 3,4-dimethylhippuric acid (30.2% dose), 2,4-dimethylbenzyl alcohol (12.7% dose, primarily as sulphate and glucuronide conjugates) and 2,5-dimethylbenzyl alcohol (11.7% dose, primarily as sulphate and glucuronide conjugates).
authors.affiliation: School of Pharmacy, University of Tasmania, Australia.
authors.forename: J Z
authors.initials: JZ
authors.lastname: Huo
authors.forename: S
authors.initials: S
authors.lastname: Aldous
authors.forename: K
authors.initials: K
authors.lastname: Campbell
authors.forename: N
authors.initials: N
authors.lastname: Davies
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D001555:Benzene Derivatives / Q000378:metabolism* / Q000493:pharmacokinetics / Q000652:urine; D002250:Carbon Radioisotopes; D008401:Gas Chromatography-Mass Spectrometry; D005965:Glucuronates / Q000652:urine; D005966:Glucuronidase / Q000378:metabolism; D006868:Hydrolysis; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D011919:Rats, Inbred Strains; D013431:Sulfates / Q000652:urine
chemical_list: D001555:Benzene Derivatives; D002250:Carbon Radioisotopes; D005965:Glucuronates; D013431:Sulfates; C010313:pseudocumene; D001192:Arylsulfatases; D005966:Glucuronidase