[Local thrombolysis of acute and subacute forearm, hand and finger artery occlusions. Early and late results].
21 patients with acute or subacute severe ischemia at the digits due to occlusions of forearm, hand and/or finger arteries were treated by local thrombolysis with urokinase. The medicament (0.6-1.1 million units per day during 1-3 days) was applied by the intraarterial route after cannulation of the cubital or radial artery. Simultaneously, heparin (20,000 units/24 hours) was infused by the same intraarterial catheter. Complete recanalization was obtained in 5 out of 21 patients, partial recanalization with significant clinical improvement in 9 additional patients. Therapeutic success was best with mean duration of symptoms lasting less than 4 weeks and in patients with embolic occlusions. After one year half of the patients had no remaining symptoms. There were no patients with acral necrosis.
Pfyffer
M
M
Schneider
E
E
Jäger
K
K
Küpferle
L
L
Bollinger
A
A
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001158:Arteries / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005385:Fingers / Q000098:blood supply*; D005500:Follow-Up Studies; D005542:Forearm / Q000098:blood supply*; D006225:Hand / Q000098:blood supply*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013927:Thrombosis / Q000188:drug therapy*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
D014568:Urokinase-Type Plasminogen Activator
Lokale Thrombolyse von akuten und subakuten Unterarm-, Hand- und Fingerarterien-verschlüssen. Früh- und Spätergebnisse.