title: Constitutional C-band polymorphism in lymphocytes from patients with chronic myeloid leukemia.
abstract: The C-band heterochromatin polymorphism of chromosomes 1, 9, and 16 was studied in lymphocytes from 53 patients with Ph1-positive chronic myeloid leukemia (CML) and 183 control persons. The patients had significantly larger heterochromatic blocks on chromosome 16 (p less than 0.01) and fewer partial inversions of chromosome 9 (p less than 0.05) than the control persons, whereas no differences were found for the symmetry/asymmetry pattern. We suggest that the increased constitutive heterochromatin regions may, via sister chromosome exchange, facilitate homo- or hemizygotization of genes which favor neoplasia development and/or progression.
authors.forename: U
authors.initials: U
authors.lastname: Kristoffersson
authors.forename: A
authors.initials: A
authors.lastname: Bernheim
authors.forename: R
authors.initials: R
authors.lastname: Berger
authors.forename: B
authors.initials: B
authors.lastname: Nilsson
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D002869:Chromosome Aberrations; D002871:Chromosome Banding; D007446:Chromosome Inversion; D002878:Chromosomes, Human, Pair 1 / Q000648:ultrastructure; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure; D002899:Chromosomes, Human, Pair 9 / Q000648:ultrastructure; D006570:Heterochromatin / Q000648:ultrastructure*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D011110:Polymorphism, Genetic; D012854:Sister Chromatid Exchange
chemical_list: D006570:Heterochromatin