Long-term course and outcome in unipolar affective and schizoaffective psychoses.
Of 301 first-time admitted patients with delusional psychoses, 50 met DSM-III criteria for major depressive disorder (MDD), 33 schizoaffective disorder, depressive type (SADD), and 94 schizophrenia. At personal follow-up after 3-39 (mean 22) years, the SADD group was recorded in between on course and outcome variables, but closer to MDD. The findings in MDD and SADD were respectively: remission 66% vs. 42%, personality disorders 14% vs. 12%, anxiety disorder or alcohol abuse 2% vs. 6%, psychosis 18% vs. 36% (with bipolar development in 2% vs. 6%, paranoid disorder 2% vs. 3%, schizophrenia 4% vs. 3%). Chronic psychosis was recorded in 10% vs. 27%. No significant outcome difference was found between early onset MDD and SADD cases and those who fell ill at a higher age. The assumption that antidepressants may induce mania could not be confirmed. Normal premorbid personality seemed to predict a favourable course.
Opjordsmoen
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Gaustad Hospital, University of Oslo, Norway.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000523:psychology* / Q000628:therapy; D003702:Delusions / Q000523:psychology; D003866:Depressive Disorder / Q000523:psychology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008370:Manuals as Topic; D008875:Middle Aged; D011581:Psychological Tests; D011618:Psychotic Disorders / Q000523:psychology* / Q000628:therapy; D012189:Retrospective Studies; D012559:Schizophrenia / Q000628:therapy; D012565:Schizophrenic Psychology