title: Heat shock stress is deleterious to CNS cultured neurons microinjected with anti-HSP70 antibodies.
abstract: CNS cultured neurons microinjected with anti-mouse immunoglobulin or anti-hsp70 antibodies and cultured at 37 degrees C remained healthy while those injected with anti-hsp70 antibodies, exposed to 50 degrees C for 15 min and returned to 37 degrees C exhibited deleterious effects i.e. lesser interconnecting neurites and poor neuronal population. This shows that heat shock stress affects the survival of neurons in vitro.
authors.affiliation: Unité Fonctionnelle de Biologie Cellulaire, C.H.U., Rennes, France.
authors.forename: N A
authors.initials: NA
authors.lastname: Khan
authors.forename: J
authors.initials: J
authors.lastname: Sotelo
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D002470:Cell Survival; D002478:Cells, Cultured; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006358:Hot Temperature / Q000009:adverse effects*; D007106:Immune Sera / Q000494:pharmacology*; D051379:Mice; D013312:Stress, Physiological / Q000378:metabolism*
chemical_list: D006360:Heat-Shock Proteins; D007106:Immune Sera