title: [Prevention of neurosensory hearing disorders in antibiotic-induced ototoxicosis].
abstract: On the basis of clinical and audiological examinations of 102 tuberculosis patients who were on a combined treatment which included aminoglycoside antibiotics (streptomycin and canamycin), neurosensory disorders of the hearing function were detected in 75% of them. A clinical trial of obsidan, a beta-blocking agent, was performed in which it was used as a protective drug against ototoxic antibiotics given to 112 patients. Its combined application with antibiotics of the aminoglycoside series decreased their toxic effect from 75.6% to 21.4%.
authors.forename: B I
authors.initials: BI
authors.lastname: Dunaĭvitser
authors.forename: M M
authors.initials: MM
authors.lastname: Davtian
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D007612:Kanamycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D008875:Middle Aged; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*; D014376:Tuberculosis / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D007612:Kanamycin; D011433:Propranolol
vernacular_title: Preduprezhdenie neĭrosensornykh narusheniĭ slukha pri antibiotikovom ototoksikoze.