title: [Potential cardiotonic agents. 1. Synthesis and pharmacologic properties of 3-cyano-2-oxaalkylamino-5-(4-pyridinyl)pyridines].
abstract: Synthesis, physicochemical properties and evaluation of positive inotropic and vasodilator activities are described in a series of substituted 2-amino-3-cyano-5-(4-pyridinyl)pyridines. Some of the 2-oxaalkylamino derivatives showed remarkable positive inotropic activities and, additionally, a decrease in blood pressure. The most potent compounds 11 and 13 have a greater activity than amrinone.
authors.affiliation: Akademie der Wissenschaften der DDR, Institut für Wirkstofforschung, Berlin.
authors.forename: V
authors.initials: V
authors.lastname: Hagen
authors.forename: A
authors.initials: A
authors.lastname: Hagen
authors.forename: S
authors.initials: S
authors.lastname: Heer
authors.forename: R
authors.initials: R
authors.lastname: Mitzner
authors.forename: H
authors.initials: H
authors.lastname: Niedrich
mesh_terms: D000631:Aminopyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000676:Amrinone / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D020105:Milrinone; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011728:Pyridones / Q000494:pharmacology
chemical_list: D000631:Aminopyridines; D002316:Cardiotonic Agents; D011725:Pyridines; D011728:Pyridones; D020105:Milrinone; D000676:Amrinone
vernacular_title: Potentielle Kardiotonika. 1. Mitteilung: Darstellung und pharmakologische Eigenschaften von 3-Cyan-2-oxaalkylamino-5-(pyrid-4-yl)pyriden.