title: Efficacy of ciprofloxacin against Leptospira interrogans serogroup icterohaemorrhagiae.
abstract: Ciprofloxacin activity against Leptospira interrogans serogroup icterohaemorrhagiae was studied in vitro and in an animal model. The MBC of ciprofloxacin was 0.6 microgram/ml. Three of three Syrian hamsters died 8 to 9 days after intraperitoneal challenge with 10(6) leptospires. In contrast, five of six animals given ciprofloxacin 3 or 5 days after challenge survived.
authors.affiliation: Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Shalit
authors.forename: A
authors.initials: A
authors.lastname: Barnea
authors.forename: A
authors.initials: A
authors.lastname: Shahar
mesh_terms: D000818:Animals; D002939:Ciprofloxacin / Q000627:therapeutic use*; D006224:Cricetinae; D007921:Leptospira interrogans / Q000187:drug effects; D008647:Mesocricetus; D013997:Time Factors; D014895:Weil Disease / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D002939:Ciprofloxacin