[UV-induced unscheduled DNA synthesis in differentiated and dedifferentiated lymphocytes from human peripheral blood under the action of DNA-repair and -replication inhibitors].
The UV-stimulated unscheduled synthesis (US) of DNA has been investigated in lymphocytes of human peripheral blood in correlation with the extent of differentiation under the action of inhibitors of DNA synthesis and repair: caffeine, hydroxyurea (HU), cytosine arabinoside (ara-C) and 3-methoxybenzamide (3-MB). The US of DNA was investigated in dedifferentiated (PGA-stimulated) and in differentiated (PGA-unstimulated) lymphocytes. Caffeine and HU inhibited US of DNA more intensely in PGA-stimulated cells, and ara-C and ara-C in combination with HU--in unstimulated cells. 3-MB enhanced US of DNA in PGA-stimulated (but not in PGA-unstimulated) lymphocytes.
Genter
E I
EI
Mikhel'son
V M
VM
Zhestianikov
V D
VD
D001549:Benzamides / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D003561:Cytarabine / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects / Q000528:radiation effects*; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D004261:DNA Replication / Q000187:drug effects* / Q000528:radiation effects; D003864:Depression, Chemical; D004347:Drug Interactions; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D010835:Phytohemagglutinins / Q000494:pharmacology; D014466:Ultraviolet Rays
D001549:Benzamides; D010835:Phytohemagglutinins; D003561:Cytarabine; D002110:Caffeine; D004247:DNA; C025159:3-methoxybenzamide; D006918:Hydroxyurea
UF-indutsirovannyĭ vneplanovyĭ sintez DNK v differentsirovannykh i dedifferentsirovannykh limfotsitakh perifericheskoĭ krovi cheloveka pri deĭstvii ingibitorov reparatsii i replikatsii DNK.