title: Heart valve replacement in septuagenarians.
abstract: Heart valve replacement was performed on 208 patients aged 70-80 years--aortic (AVR) in 172, mitral in 20 and both valves in 16 cases. All valves were of Björk-Shiley type, and all but six patients received maintenance oral anticoagulant therapy. The 100% follow-up comprised 744 patient-years (mean 4.0 years). The early mortality was 9.6% and was related to the complexity and urgency of surgery: After elective AVR for pure aortic stenosis the rate was 3.9%. Actuarial survival (early mortality excluded) was 79% at 5 years and 73% at 8 years overall, and 87% and 80% after AVR for stenosis. In the AVR group the relative (age- and -sex-adjusted) survival rate indicated a normalized survival pattern after the first year, with 87%, 'cure' rate (early mortality included), and the incidence of thromboembolism and of fatal bleeding complications equalled figures for younger patients. Mechanical heart valve implantation and maintenance anticoagulation thus seems to be safe treatment even in elderly patients, and eliminates need for valve re-replacement due to bioprosthetic degeneration.
authors.affiliation: Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Lindblom
authors.forename: U
authors.initials: U
authors.lastname: Lindblom
authors.forename: T
authors.initials: T
authors.lastname: Ivert
mesh_terms: D000206:Actuarial Analysis; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D001021:Aortic Valve; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000401:mortality / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008943:Mitral Valve; D011183:Postoperative Complications; D011379:Prognosis; D011475:Prosthesis Failure; D012086:Reoperation; D012189:Retrospective Studies; D012306:Risk
chemical_list: D000925:Anticoagulants