title: Urinary and faecal excretion of pyrene and hydroxypyrene by rats after oral, intraperitoneal, intratracheal or intrapulmonary application.
abstract: The urinary and faecal excretion of pyrene and 1-hydroxypyrene after oral (53.4%), intraperitoneal (3.1%), intratracheal (30-37%) and intrapulmonary application (0.003%) to rats has been determined by means of gas chromatography/mass spectrometry and the excretion rates were found to depend on the mode of application. With regard to the low urinary excretion rates, 1-hydroxypyrene seems not to be very suitable as a biological marker for PAH exposure to man.
authors.affiliation: Biochemical Institute for Environmental Carcinogens, Grosshansdorf, F.R.G.
authors.forename: J
authors.initials: J
authors.lastname: Jacob
authors.forename: H
authors.initials: H
authors.lastname: Brune
authors.forename: G
authors.initials: G
authors.lastname: Gettbarn
authors.forename: D
authors.initials: D
authors.lastname: Grimmer
authors.forename: U
authors.initials: U
authors.lastname: Heinrich
authors.forename: E
authors.initials: E
authors.lastname: Mohtashamipur
authors.forename: K
authors.initials: K
authors.lastname: Norpoth
authors.forename: F
authors.initials: F
authors.lastname: Pott
authors.forename: R
authors.initials: R
authors.lastname: Wenzel-Hartung
mesh_terms: D000818:Animals; D005243:Feces / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D008954:Models, Biological; D011721:Pyrenes / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011721:Pyrenes; C033146:1-hydroxypyrene