[Ocular complications in treatment with antitubercular agents in patients with chronic kidney failure on regular dialysis therapy].
A 22 years old woman suffering from renal insufficiency has been treated for 4 years by means of regular dialysis. Two years after the beginning of this therapy the renal transplantation was performed, but the graft was removed after 3 weeks. The hypertonic neuropathy was diagnosed. Patient was treated with antituberculotics, Imuran and Prednisone. After Ethambutol treatment indicated for pulmonar tbc (daily dose 11 mg per kg, the total dose of 33,6 g) the ocular side effects were pronounced: the toxical damage of both optical nerves, bilateral decrease of vision for distance and near, minute scotoma in the retinal centre of the left eye, deterioration of the vision of colours in the sense of deuteranopia. Complications were reversible, when the therapy with Ethambutol was discontinued and patient was treated with vitamins and Prednison in the total dose of 1,420 g. Authors mention also some other signs of ocular toxicity of antituberculotics.
Stibor
V
V
Lachmanová
J
J
Tomásek
R
R
D000328:Adult; D004977:Ethambutol / Q000009:adverse effects*; D005128:Eye Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D006435:Renal Dialysis; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy
D004977:Ethambutol
Ocní komplikace lécby antituberkulotiky u pacientů s chronickým selháním ledvin v pravidelném dialyzacním lécení.