title: A double-loop model for the replication of eukaryotic DNA.
abstract: Coordinated DNA synthesis of both strands at the replication fork by a fixed 'replisome' may cause dynamic and topological problems. Based upon known properties of DNA helicase, DNA primase and DNA topoisomerases, and on novel properties of DNA polymerases and DNA ligase, we propose a 'double-loop' model for the replication of eukaryotic DNA that could minimize such problems.
authors.affiliation: Istituto di Genetica Biochimica ed Evoluzionistica, CNR, Pavia, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Spadari
authors.forename: A
authors.initials: A
authors.lastname: Montecucco
authors.forename: G
authors.initials: G
authors.lastname: Pedrali-Noy
authors.forename: G
authors.initials: G
authors.lastname: Ciarrocchi
authors.forename: F
authors.initials: F
authors.lastname: Focher
authors.forename: U
authors.initials: U
authors.lastname: Hübscher
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis* / Q000235:genetics; D011088:DNA Ligases / Q000378:metabolism; D004257:DNA Polymerase II / Q000378:metabolism; D004258:DNA Polymerase III; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D008957:Models, Genetic; D008958:Models, Molecular
chemical_list: D004247:DNA; D004257:DNA Polymerase II; D004258:DNA Polymerase III; D004259:DNA-Directed DNA Polymerase; D011088:DNA Ligases