title: Transcription of the chicken histone H5 gene is mediated by distinct tissue-specific elements within the promoter and the 3' enhancer.
abstract: Molecular genetic analysis of a number of vertebrate erythroid cell-specific genes has identified at least two types of cis-acting regulatory sequences which control the complex developmental pattern of gene expression during erythroid cell maturation. Tissue-specific cellular enhancers have been identified 3' to three erythroid cell-specific genes, and additional regulatory elements have been identified in the promoters of many erythroid genes. We show that the histone H5 enhancer, like the adult beta-globin enhancer, is involved in mediating the developmental induction of histone H5 mRNA as erythroid cells mature. We also describe the preliminary characterization of a tissue-specific regulatory element within the 5' region of the H5 locus and describe investigations of the interaction between this element and the histone H5 enhancer in mediating histone H5 regulation.
authors.affiliation: Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208.
authors.forename: C D
authors.initials: CD
authors.lastname: Trainor
authors.forename: J D
authors.initials: JD
authors.lastname: Engel
mesh_terms: D000818:Animals; D002645:Chickens; D002872:Chromosome Deletion; D004742:Enhancer Elements, Genetic; D004912:Erythrocytes / Q000378:metabolism; D004920:Erythropoiesis; D005786:Gene Expression Regulation; D006657:Histones / Q000235:genetics*; D009154:Mutation; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
chemical_list: D006657:Histones