title: Tumor inhibiting properties of stereoisomeric [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)-compl exe s, Part I: Synthesis.
abstract: The synthesis of the stereoisomeric 1,2-bis(3-hydroxyphenyl)ethylenediamines (1-4) from meso-1,2-bis(2-hydroxyphenyl)ethylenediamine and 3-methoxybenzaldehyde by a diaza-Cope-rearrangement and subsequent ether cleavage with BBr3 and their conversion into the [1,2-bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)-complexes with K2PtCl4 (1-PtCl2 - 4-PtCl2) is described.
authors.forename: M
authors.initials: M
authors.lastname: Jennerwein
authors.forename: R
authors.initials: R
authors.lastname: Gust
authors.forename: R
authors.initials: R
authors.lastname: Müller
authors.forename: H
authors.initials: H
authors.lastname: Schönenberger
authors.forename: J
authors.initials: J
authors.lastname: Engel
authors.forename: M R
authors.initials: MR
authors.lastname: Berger
authors.forename: D
authors.initials: D
authors.lastname: Schmähl
authors.forename: S
authors.initials: S
authors.lastname: Seeber
authors.forename: R
authors.initials: R
authors.lastname: Osieka
authors.forename: G
authors.initials: G
authors.lastname: Atassi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002942:Circular Dichroism; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C042922:dichloro(1,2-bis(4-hydroxyphenyl)ethylenediamine)platinum II