title: Evaluations of buparvaquone as a treatment for equine babesiosis (Babesia equi).
abstract: We evaluated the efficacy of buparvaquone in eliminating Babesia equi of European origin in carrier horses and in experimentally infected splenectomized ponies. When administered at the rate of 2.5 mg/kg of body weight, IM, 4 times at 96-hour intervals, buparvaquone was effective in eliminating B equi carrier infection in 1 horse. Such results could not be repeated at the same dosage or at 3.5 or 5 mg/kg, IM. Buparvaquone given at the rate of 4 to 6 mg/kg IV and/or IM was therapeutically effective in 4 of 5 acute B equi infections in splenectomized ponies. The treated ponies became carriers.
authors.affiliation: Veterinary Teaching and Research Center, University of Idaho, Caldwell 83605.
authors.forename: J L
authors.initials: JL
authors.lastname: Zaugg
authors.forename: V M
authors.initials: VM
authors.lastname: Lane
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D001404:Babesiosis / Q000188:drug therapy*; D002353:Carrier State / Q000188:drug therapy / Q000662:veterinary*; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D008297:Male; D009285:Naphthoquinones / Q000627:therapeutic use*; D013156:Splenectomy / Q000662:veterinary; D013997:Time Factors
chemical_list: D000981:Antiprotozoal Agents; D009285:Naphthoquinones; C046326:buparvaquone