Trimethoprim resistance in urinary tract pathogens in two Nigerian hospitals.
One hundred and twenty eight (63.3%) of 202 isolates of Gram-negative bacilli from urinary infections in patients in two Nigerian hospitals were found to be resistant to trimethoprim. Of the trimethoprim-resistant organisms, 111 (86.7%) showed MICs of trimethoprim in excess of 1000 mg/l. Trimethoprim resistance was found to be transferable from 65 (50.8%) of these highly resistant organisms into Escherichia coli EC1005. The trimethoprim-resistant strains obtained in the study were also resistant to at least one other antibiotic of the nine tested.
Lamikanra
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Department of Pharmaceutics, Obafemi Awolowo University, Ile-Ife, Nigeria.
Ndep
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D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects; D009549:Nigeria; D014295:Trimethoprim / Q000627:therapeutic use; D014296:Trimethoprim Resistance / Q000235:genetics; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents; D014295:Trimethoprim