title: Analysis of the endocardium and cardiac jelly in truncal development in the cardiac lethal mutant axolotl Ambystoma mexicanum.
abstract: Recessive mutant gene c in axolotls results in a failure of the heart to function because of abnormal embryonic induction processes. The myocardium in this mutant lacks organized sarcomeric myofibrils. The present study was undertaken to determine if developmental abnormalities were evident in other areas of the heart besides the myocardium. A detailed comparative survey of the structure of developing normal and mutant hearts, including the endocardium, its cellular derivatives, and the extracellular matrix, known as cardiac jelly, showed that in the mutant there are fewer than the normal number of endocardial cells lining the heart lumen, the number of mesenchyme cells is reduced, and the cardiac jelly area is greatly enlarged in the posterior part of the truncus adjacent to the ventricle.
authors.affiliation: Department of Anatomy and Cell Biology, SUNY Health Science Center, Syracuse, 13210.
authors.forename: L F
authors.initials: LF
authors.lastname: Lemanski
authors.forename: T P
authors.initials: TP
authors.lastname: Fitzharris
mesh_terms: D000557:Ambystoma / Q000235:genetics*; D000558:Ambystoma mexicanum / Q000196:embryology / Q000235:genetics*; D000818:Animals; D006321:Heart / Q000196:embryology; D006330:Heart Defects, Congenital / Q000196:embryology* / Q000235:genetics; D008854:Microscopy, Electron; D009154:Mutation; D012016:Reference Values