C3 nephritic factor and C4 nephritic factor in the serum of two patients with hypocomplementaemic membranoproliferative glomerulonephritis.
Both C3 nephritic factor (C3NeF) and C4 nephritic factor (C4NeF) were found in the serum of two patients with hypocomplementaemic membranoproliferative glomerulonephritis type 1 (H-MPGN type 1). Both stabilizing activities were associated with the IgG fraction. The serum levels of C3 and C5 were quite low, whereas the levels of early components and control proteins were in the normal range.
Tanuma
Y
Y
Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Ohi
H
H
Watanabe
S
S
Seki
M
M
Hatano
M
M
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D003176:Complement C3 / Q000032:analysis; D003178:Complement C3 Nephritic Factor / Q000032:analysis*; D003181:Complement C4 / Q000032:analysis; D003182:Complement C5 / Q000032:analysis; D003169:Complement Inactivator Proteins / Q000032:analysis*; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male
D001323:Autoantibodies; D003176:Complement C3; D003178:Complement C3 Nephritic Factor; D003181:Complement C4; D003182:Complement C5; D003169:Complement Inactivator Proteins; D007074:Immunoglobulin G; C058872:complement 4 nephritic factor; D003165:Complement System Proteins