Effect of an aluminium-hydroxide containing antacid on the oral bioavailability of pirenzepine.
The effect of an antacid containing aluminium-hydroxide, magnesium-hydroxide and calcium carbonate (Trigastril) on the bioavailability of orally administered pirenzepine (Gastricur) was evaluated in 10 subjects in a double-blind single dose cross-over study. Pirenzepine was assayed in plasma by a highly sensitive high-performance liquid chromatographic method. A 2-compartment model was taken as a basis for the calculation of the plasma concentration curves and the pharmacokinetic parameters. The oral bioavailability of a 50 mg pirenzepine tablet concomitantly administered with 10 ml of the antacid gel preparation was slightly but not significantly greater than that of pirenzepine in the presence of a placebo gel. This was reflected by a mean increase of 18-28% in area under the curve (AUC 0-32, AUC 0-infinity, resp.) and of 26% in Cmax-values. There was no significant difference in the biological half-life of pirenzepine between the two treatments (10.1-9.4 h).
Vergin
H
H
Department of Pharmaceutical Research, Heumann Pharma GmbH & Co., Nuremberg, Fed. Rep. of Germany.
Herrlinger
C
C
Gugler
R
R
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000863:Antacids / Q000494:pharmacology*; D001682:Biological Availability; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D010890:Pirenzepine / Q000493:pharmacokinetics*; D013607:Tablets
D000863:Antacids; D013607:Tablets; D010890:Pirenzepine; D000536:Aluminum Hydroxide