[Effect of pikamilon on the cortical blood supply and microcirculation in the pial arteriole system].
Pikamilon was shown to increase blood supply in cerebral cortex in conscious rats and rabbits. The increase in blood flow has been revealed under intravenous, intraperitoneal and systemic administration of the drug. There is a pronounced dilatation of pial arterioles under pikamilon action while applied locally. Most dilation occurs in arterioles with the initial diameter of 10-20 microns. With the increase of pial arterioles diameter, dilatory effect of pikamilon, is reduced.
Mirzoian
R S
RS
Gan'shina
T S
TS
Kosoĭ
M Iu
MIu
Aleksandrin
V V
VV
Aleksandrin
P N
PN
D000818:Animals; D001160:Arterioles / Q000187:drug effects; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects*; D004567:Electrodes, Implanted; D008297:Male; D010841:Pia Mater / Q000098:blood supply / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
C044905:nicotinoyl-GABA; D005680:gamma-Aminobutyric Acid
Vliianie pikamilona na krovosnabzhenie kory i mikrotsirkuliatsiiu v sisteme pial'nykh arteriol.