The role of ubiquinones in the regulation of lipid metabolism in rat thymocytes.
The effect of ubiquinones Q-1, Q-2, Q-8 and Q-9 on lipid metabolism in rat thymocytes in vitro was studied. The cells were incubated in a medium containing ubiquinones within the concentration range from 1 to 100 microM. A 2-fold decreased cholesterol synthesis was observed in thymocytes incubated with ubiquinone Q-9 at a concentration of exogenous ubiquinone of no less than 40 microM. Incubation of thymocytes with ubiquinones UQ-1 and UQ-2 that are characteristic of rats (40 microM and 100 microM) resulted in a decrease of cholesterol synthesis. Ubiquinone-8 had a tendency to inhibit the cholesterogenesis in rat thymocytes.
Novoselova
E G
EG
Institute of Biological Physics, USSR Academy of Sciences, Moscow Region.
D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism*; D014451:Ubiquinone / Q000494:pharmacology*
D014451:Ubiquinone; D002784:Cholesterol