Regional distribution of gamma-aminobutyrate and L-glutamate uptake into synaptic vesicles isolated from rat brain.
The ATP-dependent uptake of GABA and L-glutamate into synaptic vesicles isolated from 4 different regions of the rat brain was studied. The regional distribution of the vesicular uptake was related to the Na+-dependent synaptosomal uptake, which, as a first approximation, corresponds to the distribution of GABAergic and glutamatergic terminals. The ratio found between the vesicular GABA and L-glutamate uptake varied between 1.3 and 6.2. This indicates that GABA and L-glutamate are taken up into different vesicle populations.
Fykse
E M
EM
Norwegian Defence Research Establishment, Division for Environmental Toxicology, Kjeller, Norway.
Fonnum
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D000818:Animals; D001921:Brain / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism*; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D013572:Synaptic Vesicles / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism; D013687:Telencephalon / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005971:Glutamates; D005680:gamma-Aminobutyric Acid