Hepatic drug metabolizing capacity of patients of cirrhosis before and after clinico-biochemical recovery.
The present study was undertaken to determine whether, along with clinico-biochemical recovery there was associated restoration of hepatic drug metabolizing capacity in patients of cirrhosis after treatment of their cirrhosis, using serum antipyrine half life, the ideal index. Estimation of serum antipyrine half life before (26.34 +/- 2.4 hr) and after (18.83 +/- 2 hr) clinico-biochemical recovery showed significant (P less than 0.01) improvement in drug metabolizing capacity of liver. Biochemical parameters of liver function tests except serum total proteins and prothrombin time showed simultaneous improvement.
Chauhan
C K
CK
Department of Pharmacology, L.T.M. Medical College and Hospital, Sion, Bombay.
Nanivadekar
S A
SA
Billimoria
F R
FR
D000328:Adult; D000983:Antipyrine / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D000983:Antipyrine