Gd-DISIDA--a potential contrast agent for magnetic resonance imaging of the hepatobiliary system.
Gadolinium (Gd) labeled diisopropyliminodiacetic acid (DISIDA) was prepared by mixing a Gd solution and a DISIDA solution in appropriate proportions and at controlled pH. Optimal complexation was obtained at a Gd:DISIDA molar ratio of 1:2.5 and the pH of the final solution was 7.3 to 7.5. The complex was found to be stable both in vitro and in vivo. Gd-DISIDA (12.5 mumol/kg) was injected into mice, and T1 and T2 relaxation times of various tissues were measured and compared with those of normal tissues. Only the T1 values of the blood and the liver markedly decreased after Gd-DISIDA administration and also the reduction in T1 values depended on the dose of Gd-DISIDA. Magnetic resonance imaging of the rabbit liver showed considerable contrast enhancement at 30 minutes after administration of 12.5 mumol/kg of Gd-DISIDA.
Saha
G B
GB
Bateson
B P
BP
Meaney
T F
TF
Ng
T C
TC
Go
R T
RT
MacIntyre
W J
WJ
Feiglin
D H
DH
O'Donnell
J K
JK
D000818:Animals; D001659:Biliary Tract / Q000033:anatomy & histology*; D003287:Contrast Media; D005682:Gadolinium; D007098:Imino Acids; D008099:Liver / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D009942:Organometallic Compounds; D011817:Rabbits; D019785:Technetium Tc 99m Disofenin
D003287:Contrast Media; D007098:Imino Acids; D009942:Organometallic Compounds; D005682:Gadolinium; D019785:Technetium Tc 99m Disofenin