[Human African trypanosomiasis and normality of the cerebrospinal fluid].
The authors have reviewed their experience with a combination of pentamidine and suramin for Trypanosoma Brucei - Gambiense trypanosomiasis, in order to determine the limit of cerebrospinal fluid (CSF) normality. Among 341 patients with a cerebrospinal fluid (CSF) showing 1-3 white blood cells/millilitre treated with this combination of drugs, there were 30 relapses (8.8%); among 66 patients with a cerebrospinal fluid (CSF) showing 4-5 white blood cells/millilitre, they found 9 relapses (13.6%). This difference was not statistically significant. Therefore, combination of pentamidine- was not statistically significant. Therefore, a combination of pentamidine/suramin remains an acceptable treatment for Trypanosoma brucei-gambiense sleeping sickness patients having 1-5 white blood cells/millilitre in their cerebrospinal fluid (CSF).
Pepin
J
J
Université du Manitoba, Winnipeg, Canada.
Milord
F
F
Guern
C
C
D002555:Cerebrospinal Fluid / Q000166:cytology*; D004359:Drug Therapy, Combination; D006801:Humans; D007962:Leukocytes; D010419:Pentamidine / Q000008:administration & dosage; D013498:Suramin / Q000008:administration & dosage; D014353:Trypanosomiasis, African / Q000134:cerebrospinal fluid* / Q000188:drug therapy
D013498:Suramin; D010419:Pentamidine
Trypanosomiase humaine africaine et normalité du liquide céphalorachidien.