title: Amoxycillin/clavulanic acid (Augmentin)-induced intrahepatic cholestasis.
abstract: A 75-year-old man developed a biopsy-proven, drug-induced intrahepatic cholestasis after use of amoxycillin trihydrate combined with the beta-lactam inhibitor potassium clavulanate (Augmentin). Cholestatic liver injury is an uncommonly recognized, probably immunologically based adverse reaction to therapy with penicillin and its derivatives.
authors.affiliation: Department of Gastroenterology, University College and Middlesex Hospital, Medical School, U.K.
authors.forename: J F
authors.initials: JF
authors.lastname: Dowsett
authors.forename: T
authors.initials: T
authors.lastname: Gillow
authors.forename: A
authors.initials: A
authors.lastname: Heagerty
authors.forename: M
authors.initials: M
authors.lastname: Radcliffe
authors.forename: R
authors.initials: R
authors.lastname: Toadi
authors.forename: I
authors.initials: I
authors.lastname: Isle
authors.forename: R C
authors.initials: RC
authors.lastname: Russell
mesh_terms: D000368:Aged; D000658:Amoxicillin / Q000009:adverse effects*; D019980:Amoxicillin-Potassium Clavulanate Combination; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000473:pathology; D002969:Clavulanic Acids / Q000009:adverse effects*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male
chemical_list: D002969:Clavulanic Acids; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin