title: Extensive structural homology between H-2 K/D/L antigens and non-polymorphic class I Qa, Tla and "37" molecules suggests they may act as peptide carriers.
abstract: Key structural features of H-2 K/D/L and HLA A/B/C class I molecules were identified by analysing the available sequences with reference to the 3-D structure of HLA-A2. Most of them were found to be conserved in a panel of 6 Qa and 4 Tla sequences. This finding, in addition to the high overall sequence similarity between polymorphic and non-polymorphic class I molecules strongly suggests a possible role for the latter in peptide binding, transport and/or presentation.
authors.affiliation: Unité Informatique Scientifique, Institut Pasteur, Paris.
authors.forename: A
authors.initials: A
authors.lastname: Prochnicka-Chalufour
authors.forename: J L
authors.initials: JL
authors.lastname: Casanova
authors.forename: P
authors.initials: P
authors.lastname: Kourilsky
authors.forename: J M
authors.initials: JM
authors.lastname: Claverie
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D003198:Computer Simulation; D006183:H-2 Antigens / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D012689:Sequence Homology, Nucleic Acid
chemical_list: D002352:Carrier Proteins; D006183:H-2 Antigens; D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I