The hydrogenation of alpha-hydroxymethylene-ketone derivatives to alpha-hydroxymethyl-ketone derivatives with a cell-free system of Streptomyces cinereocrocatus.
2',3'-Dihydro-5'-formylgriseofulvin (3), oxymetholone (5), and 3 beta-acetoxy-16-acetoxymethylene-5-androsten-17-one (9) were used as the substrates of a cell-free system from Streptomyces cinereocrocatus NRRL 3443. The results indicated that S. cinereocrocatus contains enzymatic activities which reduce the above three alpha-hydroxymethylene-ketones to the corresponding alpha-hydroxymethyl-ketones.
Oda
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Sato
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Sato
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D006865:Hydrogenation; D007659:Ketones / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism*
D007659:Ketones