title: Treatment of aphthae with thalidomide.
abstract: We report our experience in the treatment of major and minor aphthae with thalidomide. With doses of 100 to 300 mg daily for 3 months, a cure was obtained in 34% of cases, and marked improvement was evident in the rest. The follow-up period varied from 1 to 8 years. Two patients experienced dysesthesias, which disappeared when the medication was stopped. Thalidomide cannot be prescribed to women of childbearing potential because of its teratogenic potential.
authors.affiliation: Dermatology Unit, Güemes Institute, Buenos Aires, Argentina.
authors.forename: D
authors.initials: D
authors.lastname: Grinspan
authors.forename: G F
authors.initials: GF
authors.lastname: Blanco
authors.forename: S
authors.initials: S
authors.lastname: Agüero
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D013281:Stomatitis, Aphthous / Q000188:drug therapy*; D013792:Thalidomide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D013792:Thalidomide