[Experience in treating esophageal carcinoma with multiple fractions per day (MFD)].
We have experienced treating 29 patients of esophageal carcinoma with multiple fractions per day (MFD) examined the effectiveness of this method. A dose of 2.0 Gy was delivered to the conventional field and 1.1, 1.15, or 1.2 Gy to the gross disease at 4- to 6- hour interval for 20 days, 4 days per week. The total tumor doses were 62, 63 or 64 Gy/40 f/5 w. The following results were obtained: 1) CR rates were 44.8% on barium examination and 55.2% by endoscopic evaluation; 2) the two-year actuarial, loco-control, and disease-free survival were 49.7%, 75.5%, and 52.3%, respectively; and, 3) the acute complications were tolerable, though esophageal stricture was found to have increased in patients treated with 64 Gy.
Nishino
S
S
Dept. of Radiology, Iwate Prefectural Central Hospital.
Kikuchi
Y
Y
Sekizawa
G
G
Matsuoka
S
S
Saito
Y
Y
Amou
K
K
Uekita
Y
Y
D000206:Actuarial Analysis; D000368:Aged; D004938:Esophageal Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D004940:Esophageal Stenosis / Q000209:etiology; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D011832:Radiation Injuries; D011879:Radiotherapy Dosage; D012074:Remission Induction