Effect of unilateral decortication on acetylcholine release from the nucleus basalis.
Acetylcholine (ACh) is released from the rat nucleus basalis magnocellularis (nbM) following tissue depolarization with 35 mM K+. In the present study, we report that cholinergic neurons within the nbM undergo retrograde changes resulting in a significant reduction in K+-evoked ACh release following cortical lesions.
Boegman
R J
RJ
Department of Pharmacology and Toxicology, Queen's University, Kingston, Ont., Canada.
Metcalf
R H
RH
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001479:Basal Ganglia / Q000378:metabolism*; D002540:Cerebral Cortex / Q000502:physiology*; D002541:Cerebral Decortication; D008297:Male; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000109:Acetylcholine; D011188:Potassium