[Value of a new induction protocol in Ewing's sarcoma. Apropos of 35 cases].
The use of a protocol of induction in Ewing's sarcoma based on the sequential association of Cyclophosphamide (150 mg/m2 for 7 days) and Adriamycin (35 mg/m2 on day 8) has shown that: 1. The clinical and radiological response (scan + MRI) even when complete is not predictive of the quality of the histological response. 2. For the histological response to be predictive, it must be evaluated on a complete monobloc resection. 3. A sustained, complete remission is more frequent after systematic extratumoral monobloc surgery and appropriate postoperative chemotherapy. When these conditions are respected, a complete remission rate of 88% at 30 months can be expected.
Desbois
J C
JC
Unité d'Oncologie Pédiatrique, Hôpital Robert-Debré, Paris.
Delepine
N
N
Delepine
G
G
Housset
M
M
Cornille
H
H
Favre
R
R
Tubiana Hulin
M
M
Touzet
P
P
Jasmin
C
C
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D012512:Sarcoma, Ewing / Q000188:drug therapy*
D004317:Doxorubicin; D003520:Cyclophosphamide
Intérêt d'un nouveau protocole d'induction dans le sarcome d'Ewing. A propos de 35 cas.