title: Metastatic bone disease from occult carcinoma: a profile.
abstract: To assess the general profile of metastatic bone disease from occult primary carcinoma, the records of 172 patients with skeletal metastases seen between 1965 and 1985 were reviewed. In 51 patients (30%), the origin of the primary could not be identified when bone metastases were first diagnosed. This group were predominantly male with a high incidence of spinal metastases, cord compression and pathological fractures, and a significantly shorter (P less than 0.1) survival compared with bony metastases when the primary was known. The site of the primary was established in 33 patients (65%), mostly at autopsy. Lung carcinoma was by far the most common primary tumour in 52% of the cases, while it accounted for only 7% of those with a diagnosed primary. We believe that the onset of bony metastases from an occult source must initially raise the possibility of lung carcinoma. If the primary remains undetected, it appears justifiable to assume it to be in the lung, since the probability of a missed lung tumour being responsible for the metastases is high.
authors.affiliation: Orthopädische Universitätsklinik Balgrist, Zurich, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Nottebaert
authors.forename: G U
authors.initials: GU
authors.lastname: Exner
authors.forename: A R
authors.initials: AR
authors.lastname: von Hochstetter
authors.forename: A
authors.initials: A
authors.lastname: Schreiber
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000175:diagnosis; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary; D011379:Prognosis