[Role of supporting therapy of Juzentaiho-to (JTT) in advanced breast cancer patients].
The patients were randomized with the envelope method, dividing into either A- or B-group. A-group was treated with JTT combined with chemoendocrine therapy. B-group was treated with only chemo-endocrine therapy. Between May 1985 and December 1987, 130 pts were used for this trial, 119 pts were evaluable, and 58 pts belonged to A-group and 61 to B-group. The pts characteristics were well balanced in both those groups. There was no significant difference in the response rates between A- and B-groups. The survival rate up to 38 months was not significantly different between the two groups, but in JTT-SHO group, the survival was significantly higher in the pts belonging to the A-group (Greenwood, p less than 0.05). The quality of life (QOL) was expressed as self-assessment scores for physical condition, appetite and the coldness of extremities. It improved significantly in A-group, especially, by prevention of bone marrow suppression by chemotherapy. It was concluded that treatment with JTT is better than without JTT in treatment for advanced breast cancer patients.
Adachi
I
I
Dept. of Internal Medicine, National Cancer Center Hospital, Tokyo.
Watanabe
T
T
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000534:rehabilitation; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005474:Fluoxymesterone / Q000627:therapeutic use; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced / Q000517:prevention & control; D008875:Middle Aged; D011788:Quality of Life; D011897:Random Allocation; D013629:Tamoxifen / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000139:chemically induced / Q000517:prevention & control
D004365:Drugs, Chinese Herbal; D013629:Tamoxifen; D005474:Fluoxymesterone