title: Platelet as a model to test autonomic function in migraine.
abstract: In order to evaluate the role of the sympathetic autonomic nervous system (SANS) in common migraine we measured platelet catecholamine levels in a group of patients and in control subjects after 1 and 30 min of supine rest. Common migraine patients showed, at 1 min of supine rest, higher platelet norepinephrine (NE) content in comparison with the controls. This result may reflect a decreased release of platelet dense bodies in migraineurs. The same patients showed after 30' of supine rest a hardly significant increase of platelet NE levels in contrast to the clearly significant increase found in controls. These findings support the hypothesis of sympathetic hypofunction in migraine.
authors.affiliation: Department of Neurology, "San Bortolo" Hospital, Vicenza, Italy.
authors.forename: G
authors.initials: G
authors.lastname: D'Andrea
authors.forename: A R
authors.initials: AR
authors.lastname: Cananzi
authors.forename: M
authors.initials: M
authors.lastname: Morra
authors.forename: S
authors.initials: S
authors.lastname: Fornasiero
authors.forename: F
authors.initials: F
authors.lastname: Zamberlan
authors.forename: F
authors.initials: F
authors.lastname: Ferro-Milone
authors.forename: R
authors.initials: R
authors.lastname: Joseph
authors.forename: S
authors.initials: S
authors.lastname: Grunfeld
authors.forename: K M
authors.initials: KM
authors.lastname: Welch
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000378:metabolism / Q000503:physiopathology*; D001792:Blood Platelets / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D005260:Female; D006801:Humans; D008881:Migraine Disorders / Q000097:blood / Q000503:physiopathology*; D009638:Norepinephrine / Q000378:metabolism
chemical_list: D002395:Catecholamines; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine