[Primary anthelminthic screening on the L4 and L5 developmental stages of the lungworm, Dictyocaulus viviparus, in guinea pigs].
The study was aimed at expanding the primary anthelmintic screening to cover a model of the group of pulmonary nematodes; in this particular case to introduce the lungworm, D. viviparus, in laboratory animals. A method of primary screening for the fourth and fifth larval states of D. viviparus in guinea-pigs was worked out after the selection of a suitable laboratory host. In the primary screening, three well-known anthelmintics of the benzimidazol series, including fenbendazole, mebendazole and levamisol, were tested by the method of controlled test. The anthelmintics were administered at the recommended doses of 7.5 and 10.0 mg per kg of live weight for two days in succession. The effectiveness of the control of the 4th and 5th larval states of D. viviparus was 93.4% in fenbendazole, 89.0% in mebendazole, and 89.9% in levamisol. It is confirmed by the results of the trials that guinea-pigs can be used for the testing model of the lungworm, D. viviparus, in anthelmintic screening.
Kinkorová
J
J
Prokopic
J
J
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D004021:Dictyocaulus / Q000187:drug effects* / Q000254:growth & development; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D007814:Larva / Q000187:drug effects; D008297:Male; D014251:Trichostrongyloidea / Q000187:drug effects*
D000871:Anthelmintics
Primární anthelmintický screening na vývojová stadia L4 a L5 plicnivky Dictyocaulus viviparus u morcat.