title: Opioids in the systemic hemodynamic and renal responses to stress in spontaneously hypertensive rats.
abstract: Endogenous opioid peptides have been implicated in the regulation of cardiovascular and renal function. We tested this hypothesis by examining whether the opioid antagonist naloxone alters the cardiovascular or renal responses produced by environmental stress (air stress) in conscious spontaneously hypertensive rats (SHR). Before naloxone administration, air stress produced significant increases in heart rate, mean arterial pressure, and renal sympathetic nerve activity, and it caused a decrease in urinary sodium excretion. After intravenous and intracerebroventricular administration of naloxone, the air stress-induced pressor and antinatriuretic responses were inhibited. Subsequent studies with a different opioid antagonist, the quaternary compound naltrexone methylbromide, also showed inhibition of the air stress-induced pressor and antinatriuretic responses and demonstrated opioid receptor specificity of this inhibition. Furthermore, since only intracerebroventricular and not intravenous administration of naltrexone methylbromide inhibited the pressor and antinatriuretic responses to air stress, a central nervous system site of action was established. The opioid antagonists caused inhibition of the pressor and antinatriuretic responses to air stress without affecting the air stress-induced increase in renal sympathetic nerve activity. Our investigations indicate that central endogenous opioid peptides contribute to the pressor and antinatriuretic responses that occur in conscious SHR during acute environmental stress.
authors.affiliation: Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52246.
authors.forename: D R
authors.initials: DR
authors.lastname: Kapusta
authors.forename: S Y
authors.initials: SY
authors.lastname: Jones
authors.forename: G F
authors.initials: GF
authors.lastname: DiBona
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003243:Consciousness; D004723:Endorphins / Q000502:physiology*; D006439:Hemodynamics / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000031:analogs & derivatives / Q000494:pharmacology; D009292:Narcotic Antagonists; D009318:Natriuresis / Q000187:drug effects; D000644:Quaternary Ammonium Compounds; D051381:Rats; D011918:Rats, Inbred SHR; D013312:Stress, Physiological / Q000503:physiopathology*
chemical_list: D004723:Endorphins; D009292:Narcotic Antagonists; D000644:Quaternary Ammonium Compounds; C032257:methylnaltrexone; D009270:Naloxone; D009271:Naltrexone