Efficacy of ciprofloxacin against Leptospira interrogans serogroup icterohaemorrhagiae.
Ciprofloxacin activity against Leptospira interrogans serogroup icterohaemorrhagiae was studied in vitro and in an animal model. The MBC of ciprofloxacin was 0.6 microgram/ml. Three of three Syrian hamsters died 8 to 9 days after intraperitoneal challenge with 10(6) leptospires. In contrast, five of six animals given ciprofloxacin 3 or 5 days after challenge survived.
Shalit
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I
Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel.
Barnea
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A
Shahar
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A
D000818:Animals; D002939:Ciprofloxacin / Q000627:therapeutic use*; D006224:Cricetinae; D007921:Leptospira interrogans / Q000187:drug effects; D008647:Mesocricetus; D013997:Time Factors; D014895:Weil Disease / Q000188:drug therapy* / Q000382:microbiology
D002939:Ciprofloxacin