A patient with infantile spasms and low homovanillic acid levels in cerebrospinal fluid: L-dopa dependent seizures?
We report a 3-month-old female with infantile spasms that responded transiently to pyridoxine and permanently to oral L-dopa. Initial CSF levels of homovanillic acid were low, suggesting disturbed turnover of dopamine. These findings suggest that disturbed brain monoamine metabolism may be causally related to infantile spasms.
Sugie
H
H
Department of Paediatrics, Tokyo Women's Medical College, Japan.
Sugie
Y
Y
Kato
N
N
Fukuyama
Y
Y
D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D007223:Infant; D007980:Levodopa / Q000627:therapeutic use; D011736:Pyridoxine / Q000627:therapeutic use; D013036:Spasms, Infantile / Q000188:drug therapy / Q000503:physiopathology*
D007980:Levodopa; D011736:Pyridoxine; D004298:Dopamine; D006719:Homovanillic Acid