[Synthesis and cytostatic action of 9-nitronoracronycine].
The synthesis of 9-nitronoracronycine (12) from 1,3-dihydroxy-10-methyl-7-nitroacridone (4) and 2-chlor-2-methyl-3-butyne is reported. Screening tests with the transplantation tumor leukemia P 388 proved 4 and 1-methoxy-10-methyl-7-nitroacridone (14) to be inactive. 12 and 3-methoxy-10-methyl-7-nitroacridone (15) showed cytotoxicity in higher doses. Structure-activity relationships are discussed.
Reisch
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J
Probst
W
W
D000175:Acronine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000470:Alkaloids / Q000138:chemical synthesis*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice
D000470:Alkaloids; D000970:Antineoplastic Agents; C059842:9-nitronoracronycine; D000175:Acronine
Synthese und cytostatische Wirkung des 9-Nitronoracronycins.