title: Inhibition of glyoxalase I by new squaric acid derivatives.
abstract: Synthesis and antiglyoxalase activity of new squaric acid derivatives have been studied. It has been established that the substitution of one hydroxyl group of the squaric acid (1,2-dihydroxy cyclobutene 3,4-dione) by an N-substituted group decreased the antiglyoxalase activity while the corresponding - 2 methoxy substituted derivatives were comparatively equipotent.
authors.affiliation: Laboratoire de Chimie Biomoléculaire - Faculté des Sciences de Luminy Case 901, Marseille.
authors.forename: J L
authors.initials: JL
authors.lastname: Kraus
authors.forename: M
authors.initials: M
authors.lastname: Castaing
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D003503:Cyclobutanes / Q000138:chemical synthesis / Q000494:pharmacology*; D007791:Lactoylglutathione Lyase / Q000037:antagonists & inhibitors*; D008190:Lyases / Q000037:antagonists & inhibitors*
chemical_list: D003503:Cyclobutanes; D008190:Lyases; D007791:Lactoylglutathione Lyase; C030042:squaric acid