Prevention of the formation of arterial thrombi using different antiplatelet drugs: experimental study in dogs.
We have induced the formation of arterial thrombosis in dogs by means of an intima lesion produced by continuous current. The platelets were labeled with 111-In-oxine. Groups of 7 mongrel dogs received treatment for 7 days prior to the trial: Group I, control; Group II, 5 mg/kg body weight/day acetylsalicylic acid; Group III, 20 mg/kg body wt/day acetylsalicylic acid; Group IV, 15 mg/kg body wt/day triflusal + 5 mg/kg body wt/day dipyridamole; Group V, 15 mg/kg body wt/day triflusal; and Group VI, 5 mg/kg body wt/day acetylsalicylic acid + 5 mg/kg body wt/day dipyridamole. The only effective treatment for arterial thrombosis prevention was that employed in Group II (p less than 0.05).
Escudero-Vela
M C
MC
Servicio de Cirugía Experimental, Clínica Puerta de Hierro, Madrid, Spain.
Alvarez
L
L
Rodríguez
V
V
del Moral
J H
JH
Millán
I
I
Castillo-Olivares
J L
JL
D000818:Animals; D001241:Aspirin / Q000097:blood / Q000627:therapeutic use; D004176:Dipyridamole / Q000627:therapeutic use; D004285:Dogs; D007205:Indium Radioisotopes; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D012459:Salicylates / Q000627:therapeutic use; D012588:Scintillation Counting; D013927:Thrombosis / Q000517:prevention & control*
D007205:Indium Radioisotopes; D010975:Platelet Aggregation Inhibitors; D012459:Salicylates; C016167:triflusal; D004176:Dipyridamole; D001241:Aspirin