Cystic fibrosis: II. Altered microviscosity of erythrocyte membrane.
Erythrocyte membrane fluidity alterations in cystic fibrosis are described. The relative flexibility of the membrane was studied using lipid spin label, i.e. methyl-5-doxylpalmitate (M5DP), and pyrene as a fluorescence probe. It was found that there was a decrease of membrane fluidity in the hydrophobic midzone of the membrane, probed by pyrene, as well as at the hydrophilic surface region, probed by M5DP.
Witas
H
H
Department of Biophysics, University of Lódź, Poland.
Bartosz
G
G
Bryszewska
M
M
Gwoździński
K
K
Gondko
R
R
D002648:Child; D003550:Cystic Fibrosis / Q000097:blood*; D004910:Erythrocyte Membrane / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000378:metabolism*
D008563:Membrane Lipids