title: Evaluation of Pasteurella multocida mutants of low virulence. II. Immunologic response of turkeys.
abstract: Vaccination of turkeys by administering Pasteurella multocida mutant PM#1 or PM#3, either by the oculo-nasal-oral method or in the drinking water, induced a level of protection comparable to vaccination with the Clemson University (CU) strain or the M-9 vaccine. The level of protection was not altered when PM#1, PM#3, or the CU strain was grown in brain-heart infusion (BHI) broth or BHI agar. Under extremely severe challenges, the CU strain provided a greater level of protection than PM#1, PM#3, or the M-9 vaccine. It also was apparent from this study that the less-virulent mutant organisms and the M-9 vaccine require a higher concentration of organism per vaccine dose than the CU strain to provide similar protection.
authors.affiliation: Department of Avian Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
authors.forename: C L
authors.initials: CL
authors.lastname: Hofacre
authors.forename: J R
authors.initials: JR
authors.lastname: Glisson
authors.forename: S H
authors.initials: SH
authors.lastname: Kleven
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines; D010325:Pasteurella / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D010326:Pasteurella Infections / Q000517:prevention & control / Q000662:veterinary*; D011201:Poultry Diseases / Q000517:prevention & control*; D014422:Turkeys / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary; D014774:Virulence
chemical_list: D001428:Bacterial Vaccines