title: Do brain fluid ion concentrations change in hydrocephalus? A study on potassium and calcium in rats with congenital hydrocephalus.
abstract: Potassium and calcium have been measured in cerebrospinal fluid (CSF), brain interstitial fluid (ISF) and in plasma of congenitally hydrocephalic rats (H-Tx strain) and the results compared with a previous study on control, non-hydrocephalic, rats (CFY strain). Ion-selective microelectrodes were used to determine [K+] at 1-2 and 5 days and [Ca2+] at 1-2, 5, 10 and 20 days after birth. Total [Ca] was measured in plasma and CSF samples with atomic absorption spectrometry. In addition, K+ homeostasis has been studied in CSF and ISF during plasma hyperkalaemia at 5 days after birth. Apart from a raised [Ca2+] immediately after birth, hydrocephalic rats had similar CSF and ISF potassium and calcium concentrations to those found in control rats at the same age. The degree of CSF and ISF K+ homeostasis was also similar in hydrocephalic and control rats.
authors.affiliation: Division of Biomedical Sciences, King's College London, U.K.
authors.forename: R F
authors.initials: RF
authors.lastname: Keep
authors.forename: H C
authors.initials: HC
authors.lastname: Jones
mesh_terms: D000818:Animals; D002118:Calcium / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D004195:Disease Models, Animal; D006849:Hydrocephalus / Q000378:metabolism*; D006947:Hyperkalemia / Q000378:metabolism; D011188:Potassium / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011188:Potassium; D002118:Calcium