title: Relationship between rotational behaviour induced by apomorphine and caffeine in rats with unilateral lesion of the nigrostriatal pathway.
abstract: The contralateral rotational behaviour produced by apomorphine and caffeine has been studied in 100 rats with unilateral lesion of the nigrostriatal pathway induced with 6-OHDA. Rats with a two-peak rotational pattern induced by apomorphine, showed a greater number of contralateral turns, induced by apomorphine and caffeine, than rats which did not show this rotational pattern. A correlation was observed between the number of rotations induced by apomorphine and those induced by caffeine. A relationship between the two-peak rotational pattern induced by apomorphine and the initial-peak pattern induced by caffeine was also observed.
authors.affiliation: Laboratori de Neuropsicofarmacología i Programa Sant Pau-CITRAN, Fundació d'Investigació de la Santa Creu i Sant Pau, Hospital de Sant Pau (Medical School, U.A.B.), Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Casas
authors.forename: S
authors.initials: S
authors.lastname: Ferré
authors.forename: A
authors.initials: A
authors.lastname: Cobos
authors.forename: J M
authors.initials: JM
authors.lastname: Grau
authors.forename: F
authors.initials: F
authors.lastname: Jané
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000502:physiology*; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra / Q000502:physiology*
chemical_list: D002110:Caffeine; D001058:Apomorphine