[Gastric perfusion in the rat--a method for determining gastric secretion].
The response of the 3 postulated receptors in the parietal cell was investigated by means of a perfusion model in the rat. It was compared the effect of cimetidine and atropine on pentagastrin, histamine and carbachol stimulated gastric acid secretion with a control group. Atropine blocked the carbachol stimulation totally but did not effect pentagastrin and histamine stimulation. Cimetidine inhibited all stimulations. This method is a model for study of drugs influences of the gastric secretion.
Albrecht
R
R
Klinik und Poliklinik für Chirurgie, Martin-Luther-Universität Halle-Wittenberg.
Nowak
W
W
Blech
W
W
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D004347:Drug Interactions; D005750:Gastric Juice / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects / Q000502:physiology*
D001285:Atropine; D002927:Cimetidine; D006632:Histamine; D002217:Carbachol; D010418:Pentagastrin
Die Magenperfusion an der Ratte--eine Methode zur Beurteilung der Magnesekretion.