Mitotic arrest induced by fenvalerate in human lymphocyte cultures.
The pyrethroid insecticide fenvalerate was tested for its ability to induce C-mitosis in cultured human peripheral blood lymphocytes at concentrations ranging from 2-50 micrograms/ml. We observed a significant increase in C-mitotic figures, indicating that this compound was effective in producing disturbance of spindle function.
Carbonell
E
E
Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Spain.
Puig
M
M
Xamena
N
N
Creus
A
A
Marcos
R
R
D002478:Cells, Cultured; D006801:Humans; D007306:Insecticides / Q000633:toxicity*; D008214:Lymphocytes / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects*; D009570:Nitriles; D011722:Pyrethrins / Q000633:toxicity*
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017690:fenvalerate