title: [Effects of zopiclone on sleep, daytime somnolence and nocturnal and daytime performance in healthy volunteers].
abstract: Ten healthy volunteers, aged 20 to 39, underwent 2 adaptation nights and 3 sessions of 2 consecutive experimental nights and days at 1 week intervals. In the 3 sessions, subjects received under double blind conditions either Zopiclone 3.75 mg or 7.5 mg or placebo, according to a latin-square design. On nights 1 and 2 of each session, subjects were continuously polygraphically monitored, except for a 45 min provoked wake episode 135 min after sleep onset on night 2. Sleep continuity and architecture were evaluated during night 1, degree of daytime somnolence during day 1 and residual effects during night 2 (0 h 00) and day 2 (8 h 00 and 12 h 00). Sleep continuity was not modified, except for a reduction of the number of night awakenings. NREM sleep stage 1 was reduced and stage 2 was increased (in duration but not in percentage) with Zopiclone 3.75 and 7.5 mg. NREM sleep stages 3 and 4 were increased with Zopiclone 3.75 mg only. REM sleep was reduced (in percentage only) with Zopiclone 3.75 and 7.5 mg. Daytime somnolence varied according to the time but not with the 3 different conditions. One performance test only (choice reaction time test) showed a significant impairment at 0 h 00 with Zopiclone 7.5 mg. From a subjective point of view, sleep quality was improved and night time awakening was reduced with Zopiclone 7.5 mg.
authors.affiliation: Unité des troubles du sommeil, Service de physiopathologie des maladies nerveuses et musculaires, centre Gui-de-Chauliac, Montpellier, France.
authors.forename: M
authors.initials: M
authors.lastname: Billiard
authors.forename: A
authors.initials: A
authors.lastname: Besset
authors.forename: C
authors.initials: C
authors.lastname: de Lustrac
authors.forename: L
authors.initials: L
authors.lastname: Brissaud
authors.forename: J
authors.initials: J
authors.lastname: Cadilhac
mesh_terms: D000328:Adult; D053961:Azabicyclo Compounds; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects
chemical_list: D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone
vernacular_title: Effets de la Zopiclone sur le sommeil, la somnolence diurne et les performances nocturnes et diurnes chez le volontaire sain.