title: Serum selenium concentration, glutathione peroxidase activity and lipid peroxides in a co-twin control study on multiple sclerosis.
abstract: Serum selenium concentration, glutathione peroxidase activity and lipid peroxides were determined in patients with multiple sclerosis (MS). The series consisted of 13 same-sexed twin pairs derived from the Finnish Twin Cohort of 15,815 pairs. Fourteen subjects had a definite and 1 a probable MS, and their 11 co-twins showed no evidence of central nervous system disease. No statistical differences were observed, but the 3 patients with active progressive MS had a higher mean level of lipid peroxides than the rest of the patients. We suggest that serum lipid peroxidation may be involved in the activity of MS.
authors.affiliation: Department of Physiology, University of Oulu, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Korpela
authors.forename: E
authors.initials: E
authors.lastname: Kinnunen
authors.forename: J
authors.initials: J
authors.lastname: Juntunen
authors.forename: J
authors.initials: J
authors.lastname: Kumpulainen
authors.forename: M
authors.initials: M
authors.lastname: Koskenvuo
mesh_terms: D000328:Adult; D000368:Aged; D004200:Diseases in Twins; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000378:metabolism*; D012643:Selenium / Q000097:blood*; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
chemical_list: D008054:Lipid Peroxides; D005979:Glutathione Peroxidase; D012643:Selenium