Myxothiazol: a reversible blocker of the cell cycle.
Myxothiazol, a potent inhibitor of the cytochrome bc1 oxidoreductase, was shown by the use of flow cytometry to block reversibly the late G1/S phase of the cell cycle of human lymphoblastic T-cell line Jurkat (clone 886) at concentrations of 0.5 microgram/ml. These observations are compared to those of other drugs, such as antimycin, which effect the respiratory chain, and with O2-deficiency.
Conradt
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GBF, Gesselschaft für Biotechnologische Forschung mbH, Braunschweig, FRG.
Dittmar
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Schliephacke
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H
Trowitzsch-Kienast
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D000165:Acridine Orange; D000935:Antifungal Agents / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D005434:Flow Cytometry; D006801:Humans; D007399:Interphase / Q000187:drug effects; D015458:Leukemia, T-Cell; D008689:Methacrylates; D013844:Thiazoles / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D008689:Methacrylates; D013844:Thiazoles; C030517:myxothiazol; D000165:Acridine Orange