title: Effect of age on the pharmacokinetics of dipyrone.
abstract: The pharmacokinetics of the dipyrone metabolite, 4-methylaminoantipyrine (MAA) was evaluated, following the administration of a single oral dose of dipyrone 1.0 g to 12 young (21-30 years) and 9 elderly (73-90 years) healthy volunteers. Maximal concentration, time to peak and absorption rate of MAA were similar for both groups. The elimination half-life was 2.6 (0.2) h for the young and 4.5 (0.5) h for the elderly subjects. Total clearance of MAA, corrected for lean body mass (LBM), was lower in the elderly than in the young 2.65 vs 3.97 ml.min-1.kg-1 LBM. There was no differences between the groups in the apparent volume of distribution. A good correlation was found between the total body clearance of MAA and the creatinine clearance, which was also reduced in the elderly (r = 0.61).
authors.affiliation: Department of Medicine A. Hadassah University Hospital, Jerusalem, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Zylber-Katz
authors.forename: L
authors.initials: L
authors.lastname: Granit
authors.forename: J
authors.initials: J
authors.lastname: Stessman
authors.forename: M
authors.initials: M
authors.lastname: Levy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000632:Aminopyrine / Q000031:analogs & derivatives*; D003404:Creatinine / Q000097:blood; D004177:Dipyrone / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D047069:Pyrazolones
chemical_list: D047069:Pyrazolones; D000632:Aminopyrine; D004177:Dipyrone; D003404:Creatinine; C008667:noramidopyrine