Tissue and serum TPA in subjects at risk for bladder cancer.
We tested the presence of tumour polypeptide antigen (TPA) in lower urinary tract cells from 59 workers exposed to known bladder carcinogens and from 30 control subjects. We then correlated immunocytological expression and serum TPA levels. Lower urinary tract cells from 31 subjects gave either moderately or strongly positive immunocytological stains. Five also had high serum TPA. The detection of TPA by cytology and in serum differed significantly in workers exposed to cancer agents and the control group.
Giovagnoli
M R
MR
Department of Experimental Medicine, 1st University La Sapienza, Rome, Italy.
Di Fraia
P
P
Manna
A
A
Marafini
V
V
Valli
C
C
Marchei
P
P
Vecchione
A
A
D000328:Adult; D000588:Amines / Q000009:adverse effects; D014408:Biomarkers, Tumor / Q000097:blood / Q000652:urine; D004781:Environmental Exposure; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood* / Q000652:urine; D011863:Radioimmunoassay; D013997:Time Factors; D019396:Tissue Polypeptide Antigen; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology / Q000652:urine
D000588:Amines; D014408:Biomarkers, Tumor; D010455:Peptides; D019396:Tissue Polypeptide Antigen