Ion mobility spectrometry of halothane, enflurane, and isoflurane anesthetics in air and respired gases.
Three common gaseous anesthetics, halothane, enflurane, and isoflurane, were characterized by using ion mobility spectrometry (IMS)/mass spectrometry, and the dependence of product ion distributions on temperature and concentration was evaluated. At 40 degrees C and 500 ppb, negative ion mobility spectra in air largely consisted of monomer or dimer adducts with Br- or Cl- formed through dissociative electron capture of molecular neutrals. With increased temperature or decreased vapor concentrations, declustering and dissociation of product ions became pronounced. Ion-molecule reactions in the drift region of the IMS were evident as distortions in peak shape in the mass-resolved mobility spectra and in variable reduced mobilities for the same ions. A portable hand-held IMS was used for convenient, real-time detection of enflurane in respired gases following a controlled inhalation episode.
Eiceman
G A
GA
Shoff
D B
DB
Harden
C S
CS
Snyder
A P
AP
Martinez
P M
PM
Fleischer
M E
ME
Watkins
M L
ML
D000388:Air / Q000032:analysis*; D000777:Anesthetics / Q000032:analysis*; D004737:Enflurane / Q000032:analysis*; D006221:Halothane / Q000032:analysis*; D006801:Humans; D007530:Isoflurane / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods; D012119:Respiration; D013696:Temperature
D000777:Anesthetics; D004737:Enflurane; D007530:Isoflurane; D006221:Halothane