[Antitumor efficacy of FK 973 on malignant glioma cells].
FK 973, a new substituted dihydrobenzoxazine, was obtained by chemical modification of a novel antibiotic which was isolated from the fermentation products of streptomyces sandaensis No. 6897. FK 973 had cytotoxic effects against in vitro cultured human and murine glioma cells. The concentration of FK 973 required to inhibit cell growth by 50% was 0.06-5 micrograms/ml, after 2-day exposure of this drug against human glioblastoma (ONS-6, 12, 23, and ONS-12/ACNU), human medulloblastoma (ONS-76, 81), human neuroblastoma (ST), and murine glioblastoma (RSV-M glioma). FK 973 showed antitumor efficacy in the meningeal gliomatosis models by RSV-M glioma cells. The median survival time (MST) of models treated by FK 973 (i.t.) was 30 days. However, the MST of control group was 23 days. In the in vitro neurotoxicity test, FK 973 proved to be slightly more toxic than ACNU and MTX, but it had no crucial problems, compared with ADM.
Shimizu
K
K
Dept. of Neurosurgery, Osaka University Medical School.
Yamada
M
M
Mabuchi
E
E
Matsui
Y
Y
Tamura
K
K
Moriuchi
S
S
Park
K
K
Mogami
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology; D008727:Methotrexate / Q000494:pharmacology; D051379:Mice; D008809:Mice, Inbred C3H; D015376:Nimustine / Q000494:pharmacology; D010078:Oxazines / Q000494:pharmacology / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D010078:Oxazines; D015376:Nimustine; C054974:FK 973; D004317:Doxorubicin; D008727:Methotrexate