The effect of folic acid and 5-formyltetrahydrofolic acid on folate-deficient HEp 2 cells in culture.
Folic acid has less effect than 5-formyltetrahydofolic acid (folinic acid) in the alleviation of folate deficiency in cultured HEp 2 cells as measured by the deoxyuridine suppression test. Folic acid inhibits the metabolism of 5-formyltetrahydrofolic acid in vitro, is contraindicated in some cases of clinical folate deficiency and may be inappropriate in others.
Leeming
R J
RJ
Department of Haematology, Birmingham General Hospital, UK.
Hamon
C G
CG
Tomkyns
J G
JG
D005492:Folic Acid / Q000378:metabolism / Q000494:pharmacology*; D005494:Folic Acid Deficiency / Q000378:metabolism*; D005575:Formyltetrahydrofolates / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D013763:Tetrahydrofolates / Q000494:pharmacology*; D013936:Thymidine / Q000493:pharmacokinetics; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000378:metabolism
D005575:Formyltetrahydrofolates; D013763:Tetrahydrofolates; D005492:Folic Acid; D013936:Thymidine