Lack of effect of chlorpromazine and haloperidol on serum lipid levels and on atherogenesis in cholesterol fed rabbits.
Effects of chlorpromazine and haloperidol on serum lipid levels and on atheromotous plaques of aortae were studied in 1% cholesterol fed rabbits. To three different groups, subcutaneous injections of saline, chlorpromazine and haloperidol were given daily, following a cholesterol fed diet for twelve weeks. Serum total cholesterol and triglyceride levels were similar at 0, 6, 12 weeks among the three groups. No significant differences in the area with atheromatous plaque of aorta were noted among the three groups. Therefore, chlorpromazine and haloperidol have no preventive action against cholesterol-induced atherosclerosis in rabbits.
Saku
K
K
Department of Internal Medicine, Fukuoka University School of Medicine, Japan.
Sasaki
J
J
Arakawa
K
K
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D001835:Body Weight / Q000187:drug effects; D002746:Chlorpromazine / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D006220:Haloperidol / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D008297:Male; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D002791:Cholesterol, Dietary; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D006220:Haloperidol; D002746:Chlorpromazine