Metabolism of o,p'-DDD in humans: a novel metabolic pathway forming methylthio-containing metabolites.
Urine samples were obtained from four patients with Cushing's syndrome who had been treated with o,p'-DDD[2,2-(2-chlorophenyl,4'-chlorophenyl)1,1-dichloroethane]. Methylthio-containing (MC) metabolites and other metabolites of o,p'-DDD were detected in the urine samples by gas chromatographic mass spectrometry. These MC metabolites showed smaller peaks in the gas chromatogram than other peaks derived from other metabolites of o,p'-DDD. Although the biological significance of the pathway forming these MC metabolites is not known at present, the mechanism of the metabolic pathway was discussed.
Inouye
M
M
Department of Public Health, Kobe University School of Medicine, Japan.
Mio
T
T
Sumino
K
K
D003480:Cushing Syndrome / Q000652:urine*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D008745:Methylation; D008939:Mitotane / Q000652:urine*
D008939:Mitotane