[The correlation of the in vitro 14C-glycine absorption by murine and human leukemic cells with the antitumor effect of vincristine].
Vincristine (VCR) studied for its in vitro effect on glycine accumulation by mouse leukemic cells and blood blast cells of patients with hemoblastosis. It is found that the value of glycine cell accumulation and a degree of inhibition of the initial level of amino acid accumulation in a cell by alkaloid correlate with the antitumour action of the preparation. The glycine accumulation by blood blast cells (less than 40 nmol/min/10(9) cells), absence of the VCR effect on this process are found to be unfavourable prognostic factors for successful chemotherapy of patients by VCR. The possible role of the cellular membrane in the mechanism of the VCR action is discussed.
Sidorova
T A
TA
Volkova
M A
MA
D000818:Animals; D002250:Carbon Radioisotopes; D004353:Drug Evaluation, Preclinical; D005998:Glycine / Q000378:metabolism*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000378:metabolism*; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000378:metabolism*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000378:metabolism*; D051379:Mice; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000627:therapeutic use*
D002250:Carbon Radioisotopes; D014750:Vincristine; D005998:Glycine
Korreliatsiia pogloshcheniia 14C-glitsina in vitro leĭkoznymi kletkami mysheĭ i cheloveka s protivoopukholevym éffektom vinkristina.