No amplification or rearrangement of INT1, GLI, or COL2A1 in uterine leiomyomas with t(12;14)(q14-15;q23-24).
We have studied three uterine leiomyoma tumors, all previously cytogenetically analyzed and shown to have the clonal abnormality t(12:14)(q14-15;q23-24), with the purpose of detecting amplification or rearrangement of three genes that are localized close to the 12q breakpoint region. The genes studied were the two putative oncogenes INT1 and GLI, and the collagen type II alpha 1 gene, COL2A1. No rearrangement or amplification could be detected for any of the three gene sequences.
Arheden
K
K
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Nilbert
M
M
Heim
S
S
Mandahl
N
N
Mitelman
F
F
D002881:Chromosomes, Human, Pair 12; D002883:Chromosomes, Human, Pair 14; D003094:Collagen / Q000235:genetics; D015342:DNA Probes; D005260:Female; D005784:Gene Amplification; D005819:Genetic Markers; D006801:Humans; D007889:Leiomyoma / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D014178:Translocation, Genetic; D014594:Uterine Neoplasms / Q000235:genetics*
D015342:DNA Probes; D005819:Genetic Markers; D003094:Collagen