[Determination of thymidine kinase in the cerebrospinal fluid as a marker of leukemic meningosis].
Levels of Thymidine Kinase (TK) in cerebrospinal fluid (CSF) were longitudinally evaluated in 68 patients with acute leukemia. Values significantly above the normal range were found in all cases with meningeal involvement (in two subjects before the cytological evidence of leukemic cells in CSF). Such high levels decreased until normal values after an effective treatment. Two patients with multiple cerebral neoplastic nodules without infiltration of meninges showed normal CSF-TK values. No false positive cases were observed. Both kinetic activity and mass of leukemic cells appeared to influence CSF-TK levels. Thus, CSF-TK appears to be a promising marker in diagnosing and monitoring meningeal disease in the course of acute leukemia.
Musto
P
P
Cascavilla
N
N
Ladogana
S
S
Modoni
S
S
Carotenuto
M
M
D015415:Biomarkers / Q000134:cerebrospinal fluid; D004796:Clinical Enzyme Tests; D006801:Humans; D007938:Leukemia / Q000134:cerebrospinal fluid* / Q000201:enzymology; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid* / Q000201:enzymology; D013937:Thymidine Kinase / Q000134:cerebrospinal fluid*
D015415:Biomarkers; D013937:Thymidine Kinase
Determinazione della Timidina Kinasi nel liquor cerebrospinale quale marker della meningosi leucemica.