High-dose methylprednisolone for remission induction in children with acute nonlymphoblastic leukemia.
The effectiveness of high-dose intravenous methylprednisolone (HIVMP) in inducing an initial remission was examined in a child with acute nonlymphoblastic leukemia (ANLL). Dramatic clinical and hematological improvement with 7% marrow blasts was obtained in 3 weeks with HIVMP treatment without giving any other antileukemic drugs. Based on the results of this preliminary observation we suggest that high-dose methylprednisolone (20-30 mg/kg) might be a useful approach when applied as an initial short treatment in childhood ANLL.
Hiçsönmez
G
G
Department of Pediatrics, Hacettepe University Faculty of Medicine, Hacettepe Children's Hospital, Ankara, Turkey.
Ozsoylu
S
S
Gürgey
A
A
Zamani
V P
VP
Irken
G
G
D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D012074:Remission Induction
D008775:Methylprednisolone