title: [Pharmacokinetics of antipyrine in viral and alcoholic lesions of the liver].
abstract: Parameters of antipyrine pharmacokinetics have been studied in 82 patients with viral, alcoholic and combined liver affections and in 19 healthy subjects. All the patients exhibited changes showing a reduction of liver function responsible for drug metabolism. Disturbances of antipyrine pharmacokinetics were more pronounced in acute alcohol-aggravated hepatitis B than in hepatitis B without alcoholic aggravation.
authors.forename: V M
authors.initials: VM
authors.lastname: Tsyrkunov
authors.forename: M I
authors.initials: MI
authors.lastname: Bushma
authors.forename: P V
authors.initials: PV
authors.lastname: Garelik
authors.forename: G K
authors.initials: GK
authors.lastname: Novitskiĭ
authors.forename: L B
authors.initials: LB
authors.lastname: Zavodnik
mesh_terms: D000328:Adult; D000983:Antipyrine / Q000493:pharmacokinetics*; D001711:Biotransformation; D006509:Hepatitis B / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008108:Liver Diseases, Alcoholic / Q000378:metabolism*; D008111:Liver Function Tests
chemical_list: D000983:Antipyrine
vernacular_title: Farmakokinetika antipirina pri virusnom i alkogol'nom porazhenii pecheni.