Sustained hypertransfusion and induction of a transplantable myeloid leukemia in RLV-A-infected BALB/c mice.
Infection of BALB/c mice with the RLV-A virus typically results in an erythropoietic dysplasia characterized by hepatosplenomegaly, erythroblastosis, erythroblastemia and severe anemia without reticulocytosis. Mice hypertransfused weekly with 75%-packed red cells for 42 days prior to RLV-A infection and viral potency controls manifested this typical RLV-A response. Mice that were hypertransfused prior to and following RLV-A infection never developed the "typical" RLV-A pathogenesis. Instead, a transplantable myeloid leukemia was established. Although the reason for altered pathogenesis remains uncertain, it seems plausible that continued hypertransfusion, presumably after establishment of an altered granulopoietic microenvironment, resulted in a completely different viral expression and development of the transplantable myeloid leukemia.
Leonardi
G P
GP
Department of Biology, New York University, New York 10003.
Lobue
J
J
Manthos
M
M
Orlic
D
D
Mitra
J
J
D000818:Animals; D001803:Blood Transfusion; D001853:Bone Marrow / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006400:Hematocrit; D006410:Hematopoiesis; D007942:Leukemia, Experimental / Q000209:etiology* / Q000473:pathology; D007951:Leukemia, Myeloid / Q000209:etiology* / Q000473:pathology; D008099:Liver / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D011925:Rauscher Virus; D013154:Spleen / Q000473:pathology / Q000648:ultrastructure