Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist.
The thyroid-hormone receptor can, in the absence of its ligand, suppress activity of a responsive promoter. Addition of thyroid hormone, however, results in the stimulation of expression. The oncogenic derivative of the thyroid-hormone receptor, v-erbA, acts as a constitutive repressor and, when coexpressed with the receptor, blocks activation by thyroid hormone. Thus, v-erbA may be the first example of a dominant negative oncogene.
Damm
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Gene Expression Laboratory, Howard Hughes Medical Institute, La Jolla, California.
Thompson
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Evans
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D000818:Animals; D009189:Avian Myeloblastosis Virus / Q000235:genetics; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000235:genetics*; D002460:Cell Line; D002522:Chlorocebus aethiops; D004247:DNA / Q000378:metabolism; D005786:Gene Expression Regulation; D005822:Genetic Vectors; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000235:genetics*; D009154:Mutation; D009857:Oncogenes; D012097:Repressor Proteins / Q000235:genetics; D013963:Thyroid Hormones; D014162:Transfection; D000097810:Thyroid Hormone-Binding Proteins
D002352:Carrier Proteins; D004247:DNA; D008565:Membrane Proteins; D012097:Repressor Proteins; D013963:Thyroid Hormones; D000097810:Thyroid Hormone-Binding Proteins