Insulinlike growth factors in patients with active nephrotic syndrome.
The serum concentrations of insulinlike growth factors 1 and 2 (IGF-1 and IGF-2) were measured by specific radioimmunoassays in 25 nephrotic patients. The serum concentration of IGF-1 in nephrotic patients (mean +/- SEM, 169 +/- 17 ng/mL) was significantly lower than that observed in 20 control subjects matched for sex and age (338 +/- 36 ng/mL). The IGF-2 serum concentration was significantly lower in nephrotic patients (343 +/- 22 ng/mL) than in control subjects (898 +/- 80 ng/mL). The IGF-1 and IGF-2 150-kd and 45-kd carrier protein complexes were found in the urine of nephrotic patients, whereas there was no binding of radiolabeled IGF-1 or IGF-2 to IGF carrier proteins in the urine of control subjects. The low serum IGF-1 and IGF-2 levels observed in nephrotic patients could be partially due to the increased urinary losses of the IGF carrier proteins.
Garin
E H
EH
Department of Pediatrics, Medical University of South Carolina, Charleston.
Grant
M B
MB
Silverstein
J H
JH
D000293:Adolescent; D002352:Carrier Proteins / Q000652:urine; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000097:blood* / Q000652:urine; D007335:Insulin-Like Growth Factor II / Q000097:blood* / Q000652:urine; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood* / Q000652:urine; D013002:Somatomedins / Q000097:blood*
D002352:Carrier Proteins; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II