Treatment with polyamines can prevent monosodium glutamate neurotoxicity in the rat retina.
It has been previously shown that treatment of newborn rats with the polyamines putrescine, spermidine and spermine can rescue sympathetic neurons from naturally occurring cell death and from induced death after axotomy or immunosympathectomy. The present study demonstrates that polyamine treatment can also prevent the neurodegenerative effects in the retina and the loss of body weight caused by monosodium glutamate. The findings indicate that polyamine treatment may have a rather general beneficial effect on neuron survival.
Gilad
G M
GM
Neuropsychiatry Branch, NIMH Neurosciences Center at Saint Elizabeths, Washington, D.C. 20032.
Gilad
V H
VH
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists; D008297:Male; D009410:Nerve Degeneration / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D011073:Polyamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000187:drug effects*; D012970:Sodium Glutamate / Q000037:antagonists & inhibitors* / Q000633:toxicity
D018691:Excitatory Amino Acid Antagonists; D011073:Polyamines; D012970:Sodium Glutamate