title: Aortic reconstruction in high-risk pulmonary patients.
abstract: Seventeen patients with clinical chronic obstructive pulmonary disease (COPD) who required aortic reconstruction underwent preoperative pulmonary function testing that categorized them as extremely high risk for pulmonary complications. Ten patients (Group 1) received perioperative steroids and seven patients (Group 2) received no perioperative adjunctive steroids. The mean forced expiratory volume (FEV 1) was 45% of the predicted value in Group 1 patients and 47% in Group 2 patients. The forced expiratory flow (25% to 75%) was severely restricted in both groups: 0.47 liters per second in Group 1 (16% +/- 6% predicted value) and 0.53 liters per second (20% +/- 7% predicted value) in Group 2 patients. Using a regimen consisting of preoperative pulmonary physiotherapy, optimization of theophylline levels, and early postoperative extubation with initiation of postoperative physiotherapy resulted in survival in all cases. There did not appear to be a clear advantage to the use of adjunctive perioperative steroids. The overall incidence of pulmonary complications was 22%. Four patients died during the follow-up interval. The remaining 13 patients were alive at a mean follow-up interval of 35 months. Using a number of adjunctive techniques, successful aortic reconstruction can be accomplished in many patients with severe COPD, and the majority will survive for extended periods after operation despite their impaired pulmonary function.
authors.affiliation: Department of Surgery, Medical University of South Carolina, Charleston 29425.
authors.forename: J G
authors.initials: JG
authors.lastname: Robison
authors.forename: W C
authors.initials: WC
authors.lastname: Beckett
authors.forename: J L
authors.initials: JL
authors.lastname: Mills
authors.forename: B M
authors.initials: BM
authors.lastname: Elliott
authors.forename: R
authors.initials: R
authors.lastname: Roettger
mesh_terms: D001012:Aorta, Abdominal / Q000601:surgery*; D001018:Aortic Diseases / Q000150:complications / Q000601:surgery*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D008173:Lung Diseases, Obstructive / Q000150:complications* / Q000503:physiopathology; D008297:Male; D011182:Postoperative Care; D011300:Preoperative Care; D012129:Respiratory Function Tests; D012307:Risk Factors
chemical_list: D005938:Glucocorticoids