Spinal buprenorphine for postoperative analgesia after caesarean section.
Two doses of intrathecal buprenorphine for postoperative analgesia have been compared. Forty-five women undergoing elective caesarean section under spinal anaesthesia were randomly divided into three groups. Group A (controls, n = 15) received hyperbaric bupivacaine; Groups B and C received the same but with the addition of 0.03 mg or 0.045 mg buprenorphine, respectively. Patients receiving buprenorphine had a longer pain-free interval than the controls (P less than 0.01). Within the buprenorphine groups, patients receiving the higher dose had a longer effect (420 min s.d. 24) than those receiving the lower dose (173 min s.d. 31) (P less than 0.01) without any increase in side-effects.
Celleno
D
D
Department of Anaesthesia, Ospedale Fatebenefratelli-Isola Tiberina, Rome, Italy.
Capogna
G
G
D000328:Adult; D015360:Analgesia, Epidural; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D002047:Buprenorphine / Q000008:administration & dosage / Q000627:therapeutic use*; D002585:Cesarean Section / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D010149:Postoperative Pain / Q000517:prevention & control*; D011247:Pregnancy; D011897:Random Allocation
D002047:Buprenorphine