Diminished nociceptive response in mice following immunization with neurokinins.
Female BALB/C mice were immunized with various neuropeptides and later tested on a hot plate apparatus for responses to nociceptive stimuli. Animals immunized with substance P, neurokinin B (NKB) or fragments of either peptide were found to spend significantly longer periods of time on the hot plate than controls. Subjects treated with substance K (NKA), its N-terminal fragment or neuropeptide Y were not different from controls. Finally, mice injected with histamine or the EXON-4-related peptide were also found to exhibit delayed responses in this test situation. These results suggest roles for SP, NKB, EXON-4-related peptide and histamine in sensory processing and transmission.
Elliott
P J
PJ
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Krause
J E
JE
Cuello
A C
AC
D000698:Analgesia; D000818:Animals; D005260:Female; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D009479:Neuropeptides / Q000276:immunology / Q000494:pharmacology*; D010146:Pain / Q000276:immunology* / Q000503:physiopathology; D012016:Reference Values
D009479:Neuropeptides