Antiulcer and antisecretory ergoline derivatives.
New ergoline derivatives exhibiting antiulcer and antisecretory activities were synthesized and tested. Stereochemical modification of the ergoline skeleton was found to influence the selective activity of the compounds.
Ruggieri
D
D
Arrigoni
C
C
Di Salle
E
E
Temperilli
A
A
Giudici
D
D
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D010064:Embryo Implantation / Q000187:drug effects; D004873:Ergolines / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000897:Anti-Ulcer Agents; D004873:Ergolines