title: Acyl-CoA dehydrogenase enzymes during early postnatal development in the rat.
abstract: Fatty acid oxidation rates tend to increase with age in most developing tissues. In skeletal muscle, heart, and liver of developing rats, we measured activities of three acyl-CoA dehydrogenase enzymes, which constitute the first step in the mitochondrial beta-oxidation sequence. In skeletal muscle, activities of all three enzymes increased with age. In heart muscle, palmityl-CoA dehydrogenase increased, while the other two enzymes changed only minimally. In liver, palmityl-CoA dehydrogenase activity steadily increased with age. Decanoyl- and butyryl-CoA dehydrogenase also increased with age, but much more irregularly. We also examined the electrophoretic characteristics of these enzyme proteins in the three tissues. There were no changes in their electrophoretic patterns during development.
authors.affiliation: Department of Neurology, Medical College of Georgia, Augusta.
authors.forename: J E
authors.initials: JE
authors.lastname: Carroll
authors.forename: B S
authors.initials: BS
authors.lastname: McGuire
authors.forename: V F
authors.initials: VF
authors.lastname: Chancey
authors.forename: K B
authors.initials: KB
authors.lastname: Harrison
mesh_terms: D042964:Acyl-CoA Dehydrogenase; D044944:Acyl-CoA Dehydrogenases / Q000378:metabolism*; D000375:Aging / Q000378:metabolism; D000818:Animals; D044926:Butyryl-CoA Dehydrogenase; D004588:Electrophoresis, Cellulose Acetate; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D007527:Isoenzymes / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D009132:Muscles / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D009928:Organ Specificity; D010084:Oxidation-Reduction; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005227:Fatty Acids; D007527:Isoenzymes; D044944:Acyl-CoA Dehydrogenases; D044926:Butyryl-CoA Dehydrogenase; D042964:Acyl-CoA Dehydrogenase