title: Quantitative evaluation of chlortoluran-induced splenic hemosiderosis by means of an image analyzer.
abstract: This study investigated a technique for the quantification of hemosiderin layed down in the spleen. The model used was the rat to which the urea-based herbicide chlortoluran was fed for 90 days. There was good correlation between hematological, biochemical, histological and image analytical techniques when splenic hemosiderosis was of a moderate to severe degree. Where hemosiderosis was of a slight nature, only the technique of image analysis was able to detect the on-going changes.
authors.affiliation: Life Science research Israel, Nes Ziona.
authors.forename: A
authors.initials: A
authors.lastname: Nyska
authors.forename: T
authors.initials: T
authors.lastname: Waner
authors.forename: M
authors.initials: M
authors.lastname: Scolnik
authors.forename: A
authors.initials: A
authors.lastname: Zuckerman
authors.forename: M
authors.initials: M
authors.lastname: Pirak
authors.forename: W
authors.initials: W
authors.lastname: Kuehnberg
authors.forename: E B
authors.initials: EB
authors.lastname: Gordon
mesh_terms: D000818:Animals; D001663:Bilirubin / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D006486:Hemosiderosis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D006540:Herbicides / Q000633:toxicity*; D007091:Image Processing, Computer-Assisted; D009929:Organ Size / Q000187:drug effects; D010671:Phenylurea Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013158:Splenic Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology
chemical_list: D006540:Herbicides; D010671:Phenylurea Compounds; D001663:Bilirubin; C007033:chlortoluron