Very high dose cis-platinum (450 mg/sq m) in an infant with rhabdomyosarcoma.
The toxic effects of CDDP, erroneously given at 450 mg/sq m, are described. Life threatening gastrointestinal and myelotoxicity was observed as well as prolonged severe renal tubular acidosis without renal failure. No significant oto (brain-stem evoked responses) or neurotoxicity (EEG, neurologic examination and nerve conduction velocity) was detected indicating major age-related differences in the toxicity of this drug.
Haupt
R
R
Department of Pediatric Hematology-Oncology, Giannina Gaslini Children's Hospital, Genova, Italy.
Perin
G
G
Dallorso
S
S
Garré
M L
ML
Sobrero
A
A
D002945:Cisplatin / Q000506:poisoning / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007223:Infant; D012208:Rhabdomyosarcoma / Q000188:drug therapy*
D002945:Cisplatin