title: Interactions of the dimethyldiazaperopyrenium dication with nucleic acids. 1. Binding to nucleic acid components and to single-stranded polynucleotides and photocleavage of single-stranded oligonucleotides.
abstract: The binding of dimethyldiazaperopyrenium dication (1) with nucleosides, nucleotides, and single-stranded polynucleotides has been studied by photophysical methods. It has been shown that 1 may be a potential selective fluorescent probe for A- and/or T-rich polynucleotides. 1 efficiently cleaves oligonucleotides at guanine sites, under illumination with visible light, and therefore may be used as a sequence-specific artificial photonuclease.
authors.affiliation: Chimie des Interactions Moléculaires, Collège de France, Paris.
authors.forename: A
authors.initials: A
authors.lastname: Slama-Schwok
authors.forename: J
authors.initials: J
authors.lastname: Jazwinski
authors.forename: A
authors.initials: A
authors.lastname: Béré
authors.forename: T
authors.initials: T
authors.lastname: Montenay-Garestier
authors.forename: M
authors.initials: M
authors.lastname: Rougée
authors.forename: C
authors.initials: C
authors.lastname: Hélène
authors.forename: J M
authors.initials: JM
authors.lastname: Lehn
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D005456:Fluorescent Dyes; D009696:Nucleic Acids; D010777:Photochemistry; D011119:Polynucleotides; D011806:Quinolinium Compounds; D013053:Spectrophotometry
chemical_list: D005456:Fluorescent Dyes; D009696:Nucleic Acids; D011119:Polynucleotides; D011806:Quinolinium Compounds; C060279:dimethyldiazaperopyrenium