Antifertility principle of Ruta graveolens.
Chloroform extracts of the root, stem and leaf of Ruta graveolens L. showed significant anti-fertility activity in rats when administered intragastrically on days 1-10 post-coitum. Fractionation of the extracts led to the isolation of chalepensin as the active component with some toxicity. Time-dosing experiments demonstrated that chalepensin acts at the early stages of pregnancy. It is not clear at this stage if the anti-fertility effect is a direct manifestation of chalepensin toxicity.
Kong
Y C
YC
Lau
C P
CP
Wat
K H
KH
Ng
K H
KH
But
P P
PP
Cheng
K F
KF
Waterman
P G
PG
D000078223:5-Methoxypsoralen; D000818:Animals; D003281:Contraceptives, Postcoital / Q000302:isolation & purification; D011564:Furocoumarins / Q000302:isolation & purification / Q000494:pharmacology*; D008730:Methoxsalen / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D003281:Contraceptives, Postcoital; D011564:Furocoumarins; C020740:3-(alpha,alpha-dimethylallyl)psoralen; D000078223:5-Methoxypsoralen; D008730:Methoxsalen