[Trans-sigmoid urinary diversion and dediversion and cancer: experimental study].
The present experimental study was carried out in 75 female Wistar rats. End-to-side vesicosigmoidostomy was performed in 65; the remaining 10 rats comprised the control group. Thirty-three rats were de-diverted at 1 and 2 months later. The site of the vesicosigmoid anastomosis was assessed histologically at 1, 2, and 3 months postoperatively in diverted rats, and at 1 and 2 months in de-diverted rats. Squamous metaplastic changes and variable degrees of transitional cell line neoplasm were observed in the diverted rats. Bladder changes did not regress significantly after de-diversion. No structural changes were observed at the level of the sigmoid. This experimental animal model confirms the oncogenic potential of mixing feces and urine, and shows that de-diversion does not achieve significant regression of bladder tumor lesions.
Ramos Fernández de Soria
R
R
Núñez Núñez
R
R
Ruiz de la Hermosa
J
J
Gómez de Tejada
R
R
Blesa Sánchez
E
E
D000818:Animals; D012809:Colon, Sigmoid / Q000601:surgery; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D012074:Remission Induction; D001749:Urinary Bladder Neoplasms / Q000209:etiology* / Q000473:pathology; D014547:Urinary Diversion / Q000009:adverse effects*
Derivación y desderivación urinaria transigmoidea y cáncer: estudio experimental.