Exaggerated renal thromboxane and prostaglandin release by angiotensin II in suprarenal aortic coarctation hypertension.
The ability of angiotensin II and arachidonic acid to release immunoreactive prostaglandins into venous and ureteral effluents of rabbit isolated perfused kidneys was examined 7 days after suprarenal aortic coarctation (SRAC) or sham operation (SHAM). Renal vascular responses to angiotensin II were significantly enhanced in SRAC and accompanied by an enhanced venous efflux of bioassayable prostaglandins. Angiotension II-induced release of immunoreactive PGE2, PGF2 alpha, 6-keto PGF1 alpha and TxB2 into the venous effluent was exaggerated in SRAC. As angiotensin II did not stimulate TxB2 efflux in the SHAM group the induction of TxB2 release by SRAC is particularly noteworthy. These changes in eicosanoid release in response to angiotensin II were not mimicked by arachidonic acid administration. These results suggest that in renovascular hypertension angiotensin II-induced prostaglandin release is primarily augmented in the vascular compartment and is consistent with the sensitivity of renal function to cyclooxygenase inhibitors in renovascular hypertension.
Miller
M J
MJ
Department of Pharmacology, New York Medical College, Valhalla 10595.
McNeill
H
H
Westlin
W F
WF
Carroll
M A
MA
McGiff
J C
JC
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001017:Aortic Coarctation / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D006977:Hypertension, Renal / Q000378:metabolism* / Q000503:physiopathology; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D011453:Prostaglandins / Q000378:metabolism*; D011817:Rabbits; D011863:Radioimmunoassay; D012079:Renal Circulation / Q000187:drug effects; D013931:Thromboxanes / Q000378:metabolism*
D011453:Prostaglandins; D013931:Thromboxanes; D000804:Angiotensin II