title: A phase II study of vincristine in malignant mesothelioma--a negative report.
abstract: A total of 23 consecutive, previously untreated patients with radiographically evaluable, malignant pleural mesothelioma were treated in a phase II study with vincristine. Vincristine was given i.v. at a dose of 1.3 mg/m2 once weekly for 4 weeks, then every 2 weeks. No response was observed. The result suggests that vincristine has little or no therapeutic value in the treatment of malignant mesothelioma.
authors.affiliation: Department of Pulmonary Medicine, Renströmska Hospital, University of Göteborg, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Mårtensson
authors.forename: S
authors.initials: S
authors.lastname: Sörenson
mesh_terms: D000328:Adult; D000368:Aged; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014750:Vincristine