Pharmacological properties of tiropramide, an antispasmodic drug.
1. The pharmacological properties of an antispasmodic drug, tiropramide, were studied in isolated smooth muscle preparations. 2. Tiropramide at concentrations of 10(-6) to 10(-4) M relaxed various smooth muscles contracted spontaneously and by smooth muscle stimulants or electrical stimulation. Tiropramide did not interact with all drug-receptors examined, suggesting a pure musculotropic smooth muscle relaxant activity. 3. Tiropramide was found to inhibit both Ca uptake and Ca release in the guinea pig urinary bladder. 4. Tiropramide is considered to be useful to inhibit the contractile response of the urinary bladder, as this organ is mainly innervated by noncholinergic excitatory neurons.
Takayanagi
I
I
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan.
Hisayama
T
T
Iwase
M
M
Sakuma
N
N
Nagai
H
H
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002432:Cecum / Q000187:drug effects; D005260:Female; D005422:Flavoxate / Q000494:pharmacology; D006168:Guinea Pigs; D006633:Histamine Antagonists; D066298:In Vitro Techniques; D008297:Male; D008333:Mandelic Acids / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D018733:Nicotinic Antagonists; D010276:Parasympatholytics / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects; D014132:Trachea / Q000187:drug effects; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects; D014599:Uterus / Q000187:drug effects
D006633:Histamine Antagonists; D008333:Mandelic Acids; D018733:Nicotinic Antagonists; D010276:Parasympatholytics; D005422:Flavoxate; D014443:Tyrosine; C005419:oxybutynin; C031173:tiropramide; D002118:Calcium