title: Enhancement of oral bioavailability of d-alpha-tocopherol acetate by lecithin-dispersed aqueous preparation containing medium-chain triglycerides in rats.
abstract: In order to evaluate oral dosage forms of d-alpha-tocopherol acetate (VEA), d-alpha-tocopherol (VE) concentration in the plasma was examined following oral administration of three VEA preparations; lecithin-dispersed aqueous preparation, polysorbate 80 (PS-80)-solubilized aqueous solution and soybean oil solution. The lecithin-dispersed preparation gave the highest Cmax and the largest AUC0-24h, while Tmax was delayed. In the thoracic duct fistula rat, no increase in VE plasma concentration was observed after intraduodenal administration of lecithin-dispersed VEA preparation via the lymphatic route. The delayed Tmax and prolonged VE plasma concentration obtained with the lecithin-dispersed preparation in comparison with PS-80-solubilized aqueous solution could be explained by the different route of absorption.
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: E
authors.initials: E
authors.lastname: Fukui
authors.forename: A
authors.initials: A
authors.lastname: Kageyu
authors.forename: H
authors.initials: H
authors.lastname: Kurohara
authors.forename: Y
authors.initials: Y
authors.lastname: Kurosaki
authors.forename: T
authors.initials: T
authors.lastname: Nakayama
authors.forename: Y
authors.initials: Y
authors.lastname: Morita
authors.forename: K
authors.initials: K
authors.lastname: Shibusawa
authors.forename: S
authors.initials: S
authors.lastname: Ohsawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takeda
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D005079:Excipients; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000494:pharmacology*; D014810:Vitamin E / Q000493:pharmacokinetics*
chemical_list: D005079:Excipients; D010713:Phosphatidylcholines; D014280:Triglycerides; D014810:Vitamin E