title: [Synthesis of computer graphic calculated high-anti-fixed pyrimidine nucleoside analogs with potential virostatic and antineoplastic action].
abstract: Novel C-5 substituted 6,2'-anhydrouridines 5a-e are synthesized from the hitherto unknown monosubstituted ribofuranosylbarbituric acid derivatives 4a-e. These molecules are high-anti-fixed by a 6,2'-linkage and were assumed to show antiviral and antineoplastic effects. In cell culture test systems, however, none of these biological activities could be detected up to now.
authors.forename: G
authors.initials: G
authors.lastname: Folkers
authors.forename: G
authors.initials: G
authors.lastname: Junginger
authors.forename: C E
authors.initials: CE
authors.lastname: Müller
authors.forename: U
authors.initials: U
authors.lastname: Schloz
authors.forename: K
authors.initials: K
authors.lastname: Eger
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003196:Computer Graphics; D008956:Models, Chemical; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D011741:Pyrimidine Nucleosides
vernacular_title: Synthese computergraphik berechneter high-anti-fixierter Pyrimidin-Nucleosid-Analoga mit potentieller virostatischer und antineoplastischer Wirksamkeit.