Hatomamicin (YL-0358M-A), a new alkaloid antibiotic: fermentation, isolation, structure, and biological properties.
Hatomamicin, a new alkaloid antibiotic, was isolated from the culture filtrate of a strain of Saccharopolyspora. The antibiotic was extracted with EtOAc and purified by silica gel column chromatography. The free alkaloid was obtained as pale yellowish prisms from CH3CN solution. It exhibits antimicrobial activity against Gram-positive organisms. The apparent molecular formula of hatomamicin was determined to be C22H31NO5. The structure has been established by a combination of spectroscopic and X-ray crystallographic studies.
Imai
H
H
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
Fujita
S
S
Suzuki
K
K
Morioka
M
M
Tokunaga
T
T
Shimizu
M
M
Kadota
S
S
Furuya
T
T
Saito
T
T
D000470:Alkaloids / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured; D014961:X-Ray Diffraction
D000470:Alkaloids; D000900:Anti-Bacterial Agents; C060455:hatomamicin