title: Development of neural inducing capacity in dissociated Xenopus embryos.
abstract: During gastrulation in amphibians, dorsal ectoderm is converted by induction from an epidermal pathway to central nervous system (CNS). We show in this report that the ability of the embryo to manufacture this neural inducing signal is not dependent upon intercellular communication between early cleavage and early gastrula stages. This result is consistent with the interpretation that the cell lineage that induces CNS formation arises itself by a cell-autonomous mechanism, perhaps specified by materials inherited from the fertilized egg.
authors.affiliation: Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
authors.forename: S M
authors.initials: SM
authors.lastname: Sato
authors.forename: T D
authors.initials: TD
authors.lastname: Sargent
mesh_terms: D000199:Actins / Q000235:genetics; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics; D015815:Cell Adhesion Molecules; D002450:Cell Communication; D002490:Central Nervous System / Q000196:embryology*; D004475:Ectoderm / Q000502:physiology; D005775:Gastrula / Q000166:cytology / Q000502:physiology; D005786:Gene Expression Regulation; D008648:Mesoderm / Q000502:physiology; D009132:Muscles / Q000196:embryology; D012333:RNA, Messenger / Q000378:metabolism; D014981:Xenopus / Q000196:embryology
chemical_list: D000199:Actins; D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D012333:RNA, Messenger