[Protective action of rifampicin in experimental rabies infection of albino mice].
The paper presents the results of the experimental study of the action of rifampicin on the process of rabies infection in albino mice contaminated with 1-10 LD50 of the fixed rabies virus. Exposure to rifampicin in doses of 250 and 500 micrograms/mouse (35-70 mg/kg) resulted in survival of 66.7 and 83.4 per cent of the animals respectively while in the controls it did not exceed 16.6 and 25.0 per cent. The average life-span of the albino mice treated with the antibiotic increased 1.6-2.4-fold in comparison with the controls. The chemotherapeutic index of rifampicin representing the ratio of the maximum tolerance dose to the minimum dose providing the protective action was equal to 20. The protective action was observed either after administration of the antibiotic according to the treatment-and-prophylaxis scheme or after administration of its 2- or 3-fold dose once a day immediately after the contamination.
Zubovich
I K
IK
Votiakov
V I
VI
Mishaeva
N P
NP
Saloĭlova
T I
TI
D000818:Animals; D051379:Mice; D011818:Rabies / Q000188:drug therapy* / Q000401:mortality; D012293:Rifampin / Q000627:therapeutic use*
D012293:Rifampin
Zashchitnoe deĭstvie rifampitsina pri éksperimental'noĭ rabicheskoĭ infektsii belykh mysheĭ.