Fetal glucose utilization using maternal plasma glucose and scintillation values.
The hypothesis tested was that measurement of fetal plasma values for glucose and scintillation counts results in statistically the same calculated integrals and consequent values for cerebral glucose utilization as would be obtained if the maternal plasma values were used alone with the quantitative 2-[14C]deoxyglucose technique of Sokoloff et al. In 4 pregnant rabbits anesthetized with ketamine, a single bolus of 2-[14C]deoxyglucose was injected i.v. Fourteen periodic blood samples were taken from the adult rabbit and a single fetal placental unit simultaneously. The plasma integrals of the Sokoloff equation were calculated and compared statistically. The results demonstrate that there is no statistical difference between the maternal and fetal plasma integrals and therefore the fetal plasma values do not need to be measured for accurate measurements of fetal cerebral glucose utilization to be made using the 2-[14C]deoxyglucose technique of Sokoloff.
Kostreva
D R
DR
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011817:Rabbits
D001786:Blood Glucose