Influence of hypoxia on the age dependent stimulus-effect-relation of K+-induced dopamine release from rat brain structures.
There is a well defined correlation between stimulus intensity (potassium concentration) and the so-called fractional efflux rate of radio-labelled neurotransmitter from loaded brain structures. K+-induced dopamine release shows an age-dependent parallel shift of the stimulus-effect-relation which obviously reflects quantitative developmental changes during maturation (increasing release) and involution (restricted release) of neuronal structures and functions without modification of involved mechanisms in a qualitative manner. On the other side, mild hypoxia results in quite different, even opposite changes of the stimulus-effect-relation exhibiting the most diverse vulnerability and reactivity of neuronal stimulus-release-coupling at different age.
Mühl
K
K
Institute of Pharmacology and Toxicology, Medical Academy, Carl Gustav Carus, Dresden, DDR.
Fischer
H D
HD
Rudolph
E
E
Wustmann
C
C
Schmidt
J
J
D000375:Aging; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000254:growth & development* / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism*; D002534:Hypoxia, Brain / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D011188:Potassium; D004298:Dopamine