Cloning and characterization of bovine cytochrome P-450(11 beta) genes.
We isolated 4 different clones of the P-450(11 beta) gene from a bovine genomic library. These genomic clones were highly homologous with each other. Two of the isolated clones were pseudogenes. Determination of its nucleotide sequences indicated that the bovine P-450(11 beta) gene is divided into 9 exons by 8 introns and that it is about 8.5 kb in total length. The number of exons and the locations of intron insertion into the P-450(11 beta) gene are identical with those in the case of P-450(SCC), but different from those of other microsomal P-450s.
Hashimoto
T
T
Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka.
Morohashi
K
K
Omura
T
T
D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002417:Cattle; D003001:Cloning, Molecular; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D008969:Molecular Sequence Data; D011544:Pseudogenes
D004247:DNA; D003577:Cytochrome P-450 Enzyme System