title: Post infarction ventricular septal defect. Review of 41 surgical cases.
abstract: Forty-one patients with ventricular septal rupture after myocardial infarction were operated over about a 4-year period. The "early" group included 17 patients operated upon within the first 24 hours and 13 of them died. A total of 29 patients were operated within the first week and 21 died. The other 12 were operated after the first week since the diagnosis was made and 11 (92%) survived. The most relevant risk factors were: cardiogenic shock, hypertension and diabetes. The initial management was based on digitalis, diuretics, inotropes (dopamine, dobutamine) and the intra-aortic balloon pump. There was no significant difference in mortality between those patients with associated procedures and those without them, except in those cases of coronary grafts with infartectomy, whose mortality was higher. Early surgical repair of ventricular septal rupture implies a very high mortality (72%), which is even worse when the operation is performed within the first 24 hours (76%).
authors.affiliation: Regional Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne, UK.
authors.forename: F
authors.initials: F
authors.lastname: Guzman
authors.forename: M A
authors.initials: MA
authors.lastname: Renzulli
authors.forename: P R
authors.initials: PR
authors.lastname: Behl
authors.forename: A
authors.initials: A
authors.lastname: D'Onofrio
authors.forename: P
authors.initials: P
authors.lastname: Santé
authors.forename: S
authors.initials: S
authors.lastname: Naik
mesh_terms: D000368:Aged; D005260:Female; D006341:Heart Rupture / Q000601:surgery*; D006342:Heart Rupture, Post-Infarction / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications