title: [Aging and cerebral aminopeptidase activity].
abstract: A comparative study of brain aminopeptidase activity between 18 month old male rats and young adults of 3 months has been carried out utilizing the arylamides Leu-, Arg-, Lys-, Tyr- and Asp-beta-naphthylamide as substrates. Statistical analysis of results showed no significant differences either in areas studied or for enzymatic activities detected when both ages were compared. Two different patterns of regional distribution of enzymatic activity were observed: One came to be as a result of the use of Lys-, Arg-, Leu- or Tyr-beta-naphthylamide and the other as a result of the use of Asp-beta-naphthylamide.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad del País Vasco, Bilbao, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Gandarias
authors.forename: L
authors.initials: L
authors.lastname: Casis
authors.forename: R
authors.initials: R
authors.lastname: Múgica
authors.forename: G
authors.initials: G
authors.lastname: Aréchaga
authors.forename: M
authors.initials: M
authors.lastname: Ramírez
mesh_terms: D000375:Aging / Q000378:metabolism*; D000626:Aminopeptidases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000626:Aminopeptidases
vernacular_title: Envejecimiento y actividad aminopeptidásica cerebral.