Release of exogenously-supplied and endogenous serotonin from tissue slices of Hymenolepis diminuta.
The release of exogenously-supplied [3H]serotonin and of endogenous serotonin from H. diminuta tissue slices was studied using high [K+] depolarization. The release of [3H]serotonin was not calcium-dependent or magnesium-antagonized. While high-magnesium antagonism of endogenous serotonin release was inconclusive, this release was calcium-dependent. These findings suggest that, while exogenous serotonin is not taken into and released from nervous tissue, endogenous serotonin appears to be released from nervous tissue in a neurotransmitter-like manner.
Gordon
B
B
Department of Biology, York University, North York, Ont., Canada.
Webb
R A
RA
D000818:Animals; D002118:Calcium / Q000502:physiology; D006926:Hymenolepis / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D066298:In Vitro Techniques; D011188:Potassium / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism* / Q000493:pharmacokinetics
D012701:Serotonin; D011188:Potassium; D002118:Calcium