[Immunosuppressive activity of the blood serum of patients with cancer of the corpus uteri].
In 40 patients with endometrial carcinoma of I-IV stage reaction of suppression of migration and adhesion of leukocytes (RSML and RSAL) in response to antigen prepared from the same tumour and in the presence of autoserum of blood of these patients, was studied. The index of antibody-forming cells (IAFC) and percentage of rosette-producing cells (RPC) in mice spleen after their infusion before immunization by sheep erythrocytes blood serum of the mentioned patients were also investigated. It was ascertained, that in all cases with using of autoserum of patients with endometrial carcinoma, especially on late stages, significant diminution of positive RSML and RSAL and decrease of IAFC and RPC take place. It was concluded that blood serum of patients with endometrial carcinoma gives evidence of immunosuppressive activity at late stages of the process.
Movsesian
M A
MA
Adamian
R T
RT
Pogosian
N V
NV
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007114:Immunization; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012397:Rosette Formation; D014594:Uterine Neoplasms / Q000276:immunology*
Immunosupressivnaia aktivnost' syvorotki krovi bol'nykh rakom tela matki.