title: The pharmacologic activity of complexes and mixtures with copper and salicylates or aminopyrine following oral dosing in rats.
abstract: Cu(II) complexes with salicylates or aminopyrine were administered to rats with local inflammation (acute paw oedema elicited with carrageenan) to determine their anti-inflammatory activity and ulcerogenic effects following oral administration. The complexes were more effective than the parent ligands or appropriate mixtures of these ligands with Cu(II) as anti-inflammatory agents. All complexes indicated low ulcerogenity. The differences in pharmacologic activity between the complexes and mixtures in question are discussed.
authors.affiliation: Department of Pharmacology, Medical Academy, Gdańsk, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Korolkiewicz
authors.forename: E
authors.initials: E
authors.lastname: Hać
authors.forename: I
authors.initials: I
authors.lastname: Gagało
authors.forename: P
authors.initials: P
authors.lastname: Gorczyca
authors.forename: A
authors.initials: A
authors.lastname: Lodzińska
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002351:Carrageenan; D003300:Copper / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D007249:Inflammation; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012459:Salicylates / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D013276:Stomach Ulcer / Q000139:chemically induced*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009942:Organometallic Compounds; D012459:Salicylates; C025564:copper salicylate complex; D003300:Copper; D002351:Carrageenan