Pharmacokinetics of iopamidol 370 in infants and children during ivp.
This research was aimed at evaluating the pharmacokinetic parameters of iopamidol 370 (a nonionic water organic iodine compound) during ivp in infants and children. All children examined in the study had symptomatic recurrent urinary tract infections; they were divided into three groups according to age (0-24 months; 25-72 months; 73-120 months). The contrast medium was injected in a dose of 1 ml/kg + 6 ml. Blood and urine samples were taken at regular time intervals over a 24-hour period in children, whereas in infants only blood samples were collected. Pharmacokinetic parameters were estimated using a bicompartmental open model, as follows: t1/2 alpha (h) = 0.33; t1/2 beta (h) = 1.92; Vc (l/kg) = 0.40; V beta (l/kg) = 0.20; Cl (l/kg) = 0.16. These values were not significantly different, as far as our patients were concerned, from those reported in literature for adults.
Beluffi
G
G
Servizio di Radiodiagnostica, IRCCS Policlinico S. Matteo, Pavia.
Cerutti
R
R
Fiori
P
P
Martini
A
A
D000375:Aging / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006801:Humans; D007223:Infant; D007479:Iopamidol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D013997:Time Factors; D014567:Urography
D007479:Iopamidol