title: Psychological effects of Neurotropin in man under normal conditions and after sleep deprivation: a double-blind placebo study.
abstract: Psychological effects of Neurotropin--a widely used analgesic in Japan--have been evaluated in a double blind cross-over study on volunteers belonging to the nursing staff of a hospital under sleep deprivation or not. Each subject was asked to record his feelings by self-assessment on scales registering the following states: fatigue-/rest+, mental stress-/relaxation+, cold sensation-/comfort+, dissatisfaction-/satisfaction+. Neurotropin was shown to be devoid of demonstrable psychological effects in the subjects under normal sleeping conditions. After sleep deprivation, Neurotropin globally determined significantly more psychological evolutions towards positives+ and less towards negative- mood than inactive placebo. From the self-assessed feelings, euphoria was unaffected, whereas Neurotropin significantly reduced fatigue and improved relaxation and comfort. These results are compared with the observations made on animals submitted to Specific Alternation of Rhythm in Temperature (SART) where Neurotropin relieves such symptoms as hyperalgesia. This model for experimental pain study corresponds to a depletion of brain serotonin and catecholamines. The effects of Neurotropin on exhausted volunteers could, as in the SART model, be due to an inhibition of monoaminergic depletion. The relevance of this finding to some association of chronic pain and psychogenic factors is to be considered.
authors.forename: J C
authors.initials: JC
authors.lastname: Genon
authors.forename: C
authors.initials: C
authors.lastname: Thiebauld
authors.forename: J
authors.initials: J
authors.lastname: Lintermans
authors.forename: G
authors.initials: G
authors.lastname: De Heyn
mesh_terms: D000328:Adult; D000700:Analgesics / Q000494:pharmacology*; D003080:Cold Temperature; D004311:Double-Blind Method; D005221:Fatigue; D006801:Humans; D008297:Male; D010549:Personal Satisfaction; D011134:Polysaccharides / Q000494:pharmacology*; D012063:Relaxation; D012892:Sleep Deprivation
chemical_list: D000700:Analgesics; D011134:Polysaccharides; C010491:neurotropin