Percutaneous toxicity of ethylene glycol monomethyl ether and of dipropylene glycol monomethyl ether in the rat.
The subacute percutaneous toxicity of dipropylene glycol monomethyl ether (DPM) in male rats dosed 5 days/week for 4 weeks under both occluded and unoccluded conditions has been assessed and compared to the percutaneous toxicity of ethylene glycol monomethyl ether (EGM). DPM caused no significant changes in the clinical chemistry, haematology, or pathology, whereas EGM caused changes in the haematology and clinical chemistry, and both testicular and bone marrow damage at doses of 1000 mg/kg per day.
Fairhurst
S
S
Toxicology and Pathology Sections, Chemical Defence Establishment, Salisbury, Wiltshire, U.K.
Knight
R
R
Marrs
T C
TC
Scawin
J W
JW
Spurlock
M S
MS
Swanston
D W
DW
D000287:Administration, Topical; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005026:Ethylene Glycols / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D011409:Propylene Glycols / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012997:Solvents
D005026:Ethylene Glycols; D011409:Propylene Glycols; D012997:Solvents; C042175:dipropylene glycol monomethyl ether; C005219:methyl cellosolve