title: Human excimer laser lamellar keratectomy. A clinical study.
abstract: The first ten blind human eyes in the United States to receive excimer laser (ArFl 193 nm) lamellar keratectomy (reprofiling) are presented. Seven of these patients were followed 6 to 12 months after ablation. All eyes are grossly clear in the region of ablation. Results of slit-lamp examination of all flattened ablated areas show mild superficial haze at the epithelial/stromal interface. This haze might not interfere significantly with vision in patients 7 to 10. Serial pachymetry and keratometry measurements, refraction, and digital keratoscopy show a progressive filling in of the excavated area by approximately two thirds but a loss of initial diopteric correction of only one third. Histopathologic analysis was obtained for four eyes. Transmission electron microscopy of three eyes enucleated 3 to 12 days after ablation shows 40-microns ablation depths through Bowman's layer and superficial stroma with minimal adjacent tissue damage and no inflammatory cells. The epithelium is increased in thickness by 50%, and firmly attached to the underlying stroma. A 4-month postablation specimen shows keratocyte activation with increased protein synthesis (presumed collagen and ground substance).
authors.affiliation: Surgical Research Center, Department of Surgery, University of Connecticut Health Center, Farmington.
authors.forename: D M
authors.initials: DM
authors.lastname: Taylor
authors.forename: F A
authors.initials: FA
authors.lastname: L'Esperance
authors.forename: R A
authors.initials: RA
authors.lastname: Del Pero
authors.forename: A D
authors.initials: AD
authors.lastname: Roberts
authors.forename: J E
authors.initials: JE
authors.lastname: Gigstad
authors.forename: G
authors.initials: G
authors.lastname: Klintworth
authors.forename: C A
authors.initials: CA
authors.lastname: Martin
authors.forename: J
authors.initials: J
authors.lastname: Warner
mesh_terms: D001766:Blindness / Q000209:etiology; D003315:Cornea / Q000601:surgery*; D003316:Corneal Diseases / Q000473:pathology / Q000601:surgery*; D004847:Epithelial Cells; D005134:Eye Neoplasms / Q000150:complications; D005500:Follow-Up Studies; D005901:Glaucoma / Q000150:complications; D006801:Humans; D053685:Laser Therapy; D008545:Melanoma / Q000150:complications; D013997:Time Factors; D014466:Ultraviolet Rays