title: Combination chemotherapy with vinblastine, ifosfamide and cisplatin in bulky seminoma.
abstract: Since 1982, 24 patients with bulky seminoma were treated with the VIP-regimen consisting of vinblastine 6 mg/m2 days 1+2, ifosfamide 1.5 g/m2 days 1-5, cisplatin 20 mg/m2 days 1-5. One patient showed primary progression, another patient partial remission, and one patient died during the first cycle. All the other patients had complete remission (21/24 = 87%), which was documented histologically in 9 patients. One patient relapsed but obtained complete remission after repeated treatment. Thus 21 patients are currently living without disease after a median observation time of 30+ months. Bone marrow toxicity was severe, leading to dose reduction in more than 50% of the patients. No other severe side effects were observed. We conclude that the regimen is highly effective in bulky seminoma. Reduction of the vinblastine dose is recommended because of bone marrow toxicity.
authors.affiliation: Department of Internal Medicine III, University of Munich, West Germany.
authors.forename: C
authors.initials: C
authors.lastname: Clemm
authors.forename: R
authors.initials: R
authors.lastname: Hartenstein
authors.forename: N
authors.initials: N
authors.lastname: Willich
authors.forename: G
authors.initials: G
authors.lastname: Ledderose
authors.forename: W
authors.initials: W
authors.lastname: Wilmanns
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004407:Dysgerminoma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008875:Middle Aged; D009367:Neoplasm Staging; D012074:Remission Induction; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D014747:Vinblastine; D002945:Cisplatin; D007069:Ifosfamide