[Comparison of the effect of Lasolvan and betamethasone on lung maturity of fetal rabbits].
8 rabbits received Lasolvan i.v. on day 25, 26 and 27 of pregnancy. 8 rabbits received betamethasone i.m. on 26th and 27th day of pregnancy. The control group received 0.9% NaCl. On day 28 of pregnancy the caesarean section was carried out, the newborn rabbits killed after 45 minutes. In their lungs the lecithin contents was significantly higher in the Lasolvan group than in the betamethasone group and control group, but in the betamethasone group not significantly higher than in the control group. Betamethasone caused in the fetuses the lowering of the body weight, of the wet weight of lungs, of the dry weight lungs and the increase of the pulmonary fluid contents. Lasolvan had no such undiserable effect.
Stepińska
J
J
Klinik für Pathologie der Schwangerschaft und Geburt, Medizinischen Akademie Szczecin, Polen.
Zbisławska
P
P
Skoczowska
W
W
Cretti
A
A
D000551:Ambroxol / Q000494:pharmacology*; D000818:Animals; D001623:Betamethasone / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D001964:Bromhexine / Q000031:analogs & derivatives*; D005260:Female; D005325:Fetal Organ Maturity / Q000187:drug effects*; D007262:Infusions, Intravenous; D008168:Lung / Q000196:embryology*; D009929:Organ Size / Q000187:drug effects; D010713:Phosphatidylcholines / Q000378:metabolism; D011247:Pregnancy; D011817:Rabbits; D013109:Sphingomyelins / Q000378:metabolism
D010713:Phosphatidylcholines; D013109:Sphingomyelins; D000551:Ambroxol; D001623:Betamethasone; D001964:Bromhexine
Der Vergleich des Einflusses von Lasolvan und von Betamethason auf die Lungenreife fetaler Kaninchen.