Effect of topical timolol maleate on the ophthalmic artery blood pressure.
The effects of topical timolol maleate 0.5% on the ophthalmic artery diastolic (OABPd), systolic (OABPs) and mean blood pressure (OABPm) were investigated in 19 healthy subjects using compression ophthalmodynamometry. In a randomized, double-blind study, one eye of each subject received one drop of timolol maleate 0.5% and the fellow eye received a drop of placebo. Measurements of OABPd and OABPs were performed just prior to instillation of the drops, and then 2 hr later. OABPm was calculated as OABPm = OABPd + 1/3 (OABPs - OABPd). No significant changes in OABPd, OABPs or OABPm were observed following the drops in the timolol-treated eyes or in the placebo-treated eyes. A significant difference (P = 0.0198) was found, however, when the changes in OABPm occurring in the timolol-treated eyes were compared with the changes occurring in the placebo-treated eyes, suggesting that the drug may have an effect upon ophthalmic artery pressure and retinal artery pressure that is expressed differently in each eye.
Grunwald
J E
JE
Scheie Eye Institute, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia 19104.
Furubayashi
C
C
D000287:Administration, Topical; D000328:Adult; D001794:Blood Pressure; D001916:Brachial Artery; D006801:Humans; D007429:Intraocular Pressure; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000187:drug effects* / Q000502:physiology; D009884:Ophthalmodynamometry; D013999:Timolol / Q000494:pharmacology*
D013999:Timolol