[Protective effects of the Chinese medicine Juzentaiho-to from the adverse effects of mitomycin C and cisplatin].
Some Chinese medicines in Japan have been reported to have not only antitumour effects, but also to offer protection from the adverse effects of anti-tumour agents. However, there is controversy regarding the protective effects of such Chinese medicines against the adverse effects of anti-tumour agents, in this study, we examined the effects of Tsumura Juzentaiho-to (TJ-48) on the toxicity of mitomycin C (MMC) and cisplatin (CDDP). Both the pre-administration of TJ-48 a single time and for seven days shifted the dose response curve and LD50S of MMC and CDDP to the right. Seven days of treatment using TJ-48 delayed deaths due to lethal dose of MMC or CDDP and markedly changed their survival curves. Also, TJ-48 reduced the atrophy of the testis, thymus and spleen caused by MMC. TJ-48 also had beneficial effects on leukopenia, anemia and body weight loss caused by MMC, and increase of BUN and creatinine caused by CDDP. These results indicate that the combined use of TJ-48 may be a new way to in prevent or minimize the toxicity of MMC or CDDP.
Iijima
O T
OT
Tsumura and Co. Research Institute for Pharmacology.
Fujii
Y
Y
Funo
S
S
Hosoya
E
E
Yamashita
M
M
D000740:Anemia / Q000139:chemically induced / Q000517:prevention & control; D000818:Animals; D001806:Blood Urea Nitrogen; D002945:Cisplatin / Q000009:adverse effects* / Q000493:pharmacokinetics; D003404:Creatinine / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007928:Lethal Dose 50; D007970:Leukopenia / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008937:Mitomycins / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D015431:Weight Loss / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D008937:Mitomycins; D003404:Creatinine; D002945:Cisplatin