Kynurenic acid protects against gastroduodenal ulceration in mice injected with extracts from poisonous Atlantic shellfish.
1. Mice were treated with an extract prepared from poisonous Atlantic mussels. 2. Gastric and duodenal ulcers, duodenal hyperemia and peritoneal ascites resulted from administration of the shellfish extract, with an LD84 of 1.0 ml. 3. Kynurenic acid, an antagonist at excitatory amino acid receptors, protected significantly against gastroduodenal ulcers, ascites and hyperemia when given at 60 or 75 min post-extract. 4. It is likely that the gastrointestinal damage evoked by this extract is due to its domoic acid content and that kynurenic acid may prove useful against domoic acid-induced gastropathy.
Glavin
G B
GB
Department of Pharmacology, University of Manitoba, Winnipeg, Canada.
Bose
R
R
Pinsky
C
C
D000818:Animals; D004064:Digestive System / Q000187:drug effects / Q000473:pathology; D004381:Duodenal Ulcer / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D007736:Kynurenic Acid / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D057096:Shellfish Poisoning; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D014020:Tissue Extracts / Q000633:toxicity
D014020:Tissue Extracts; D007736:Kynurenic Acid