title: The control of potassium (86Rb+) efflux in the isolated human sweat gland.
abstract: Sweat glands, isolated from strips of human skin and pre-loaded with 86Rb+, a marker of potassium transport, were superfused with physiological saline and rate constants for 86Rb+ efflux calculated. The rate of efflux during superfusion with Ca2+-free saline was lower than that measured in the presence of calcium (2.56 mM). Acetylcholine increased the rate of 86Rb+ efflux and this response could be resolved into two components: an initial transient phase which was Ca2+-independent and a slowly declining Ca2+-dependent phase. Adrenaline only caused a Ca2+-dependent increase in efflux. It is suggested that the potassium permeability of the secretory cells increases during activity.
authors.affiliation: Institute of Physiology, University of Glasgow.
authors.forename: D L
authors.initials: DL
authors.lastname: Bovell
authors.forename: H Y
authors.initials: HY
authors.lastname: Elder
authors.forename: D M
authors.initials: DM
authors.lastname: Jenkinson
authors.forename: S M
authors.initials: SM
authors.lastname: Wilson
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D002118:Calcium / Q000502:physiology; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D011188:Potassium / Q000493:pharmacokinetics*; D012414:Rubidium Radioisotopes; D013545:Sweat Glands / Q000187:drug effects / Q000378:metabolism*
chemical_list: D012414:Rubidium Radioisotopes; D000109:Acetylcholine; D011188:Potassium; D002118:Calcium; D004837:Epinephrine