Effects of high dose intraperitoneal cytosine arabinoside on the radiation tolerance of the rat spinal cord.
The effect of intraperitoneal high dose (9 g/kg) Cytosine Arabinoside (Ara-C) on the early delayed radiation response of the rat cervical spinal cord has been studied. When given 2 hrs before irradiation, systemically administered Ara-C significantly reduces the isoeffect doses for the induction of paralysis due to white matter necrosis by a factor of approximately 1.2 for both a single irradiation treatment and for a two fraction irradiation with 24 hr interval. No effect on the latency time to develop paralysis was recorded.
Menten
J
J
Dept. of Experimental Radiotherapy, University Hospital St. Rafaël, Leuven, Belgium.
Landuyt
W
W
van der Kogel
A J
AJ
Ang
K K
KK
van der Schueren
E
E
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003561:Cytarabine / Q000008:administration & dosage / Q000633:toxicity*; D004307:Dose-Response Relationship, Radiation; D007274:Injections, Intraperitoneal; D008297:Male; D009336:Necrosis; D011836:Radiation Tolerance; D051381:Rats; D011919:Rats, Inbred Strains; D013118:Spinal Cord Diseases / Q000209:etiology*
D003561:Cytarabine