[Mechanism of the hypotensive effect of sodium oxybutyrate in pulmonary hypertension in experimental tuberculosis in dogs].
The mechanism of sodium oxybutyrate effect on the lung vessels under normal conditions and under conditions of experimental tuberculosis in dogs was studied by the time course of pressure in the pulmonary artery and the content of serotonin, histamine and adenosine in blood of the aorta and pulmonary artery after the drug intravenous administration. To confirm the antihypoxic effect of sodium oxybutyrate, the levels of lactate, pyruvate, ATP, ADP and AMP were investigated. The levels of adenosine were judged indirectly by the activity of 5-nucleotidase, adenosine desaminase and AMP. It was shown that the decrease in pressure in the pulmonary artery after the use of sodium oxybutyrate was connected with the drug antihypoxic effect which led to lower levels of histamine in the aorta blood under the normal conditions and to higher levels of adenosine under the conditions of tuberculosis.
Priĭmak
A A
AA
Borisova
M I
MI
Smirnova
N A
NA
Kremer
O V
OV
Kruglova
E G
EG
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000378:metabolism; D011651:Pulmonary Artery / Q000187:drug effects; D012978:Sodium Oxybate / Q000494:pharmacology / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000150:complications*
D006885:Hydroxybutyrates; D012978:Sodium Oxybate
O mekhanizme gipotenzivnogo deĭstviia oksibutirata natriia pri legochnoĭ gipertenzii u zarazhennykh tuberkulezom sobak.