Molecular characterization of human X/Y translocations suggests their aetiology through aberrant exchange between homologous sequences on Xp and Yq.
Several DNA sequences from two homologous regions, localized on the distal part of the human X chromosome short arm and on the long arm of the Y chromosome, have been hybridized to DNAs from seven human-rodent hybrids containing human X; Y translocation chromosomes. Molecular characterization of the translocated chromosomes has revealed, in all but one case, transfer of the Y cluster of sequences and complete deletion of the corresponding X-chromosomal sequences. The possible role of X/Y homology in the aetiology of X; Y translocations is proposed.
Ballabio
A
A
Department of Paediatrics, University of Naples, Italy.
Carrozzo
R
R
Gil
A
A
Gillard
B
B
Affara
N
N
Ferguson-Smith
M A
MA
Fraser
N
N
Craig
I
I
Rocchi
M
M
Romeo
G
G
D002460:Cell Line; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D005260:Female; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D009693:Nucleic Acid Hybridization; D012689:Sequence Homology, Nucleic Acid; D014178:Translocation, Genetic; D014960:X Chromosome; D014998:Y Chromosome
D015342:DNA Probes; D004247:DNA