[The biological properties and drug sensitivity of rat bladder cancer implanted into the subcutis and the bladder wall of rats].
The biological properties and drug sensitivity of rat bladder tumor BC-47 implanted into either the subcutis or the bladder wall of ACI/N rats were compared. The growth rate of tumors implanted into the bladder wall was about one third slower than that of the subcutaneous tumors at mid-log phase. Tumors in the bladder wall showed an invasive growth into the mucosa and the muscularis propria with few formations of capsules. In contrast, the subcutaneous tumors grew expansively and formed thick capsules. The tumors in the subcutis and bladder wall were remarkably sensitive to adriamycin. The tumor in the subcutis was sensitive to peplomycin, but that in the bladder wall was insensitive. The sensitivity of tumor in the bladder wall to adriamycin and peplomycin was consistent with the clinical efficacy of these drugs against human bladder cancers. These results suggest that models in which the tumor is implanted into its original organ are useful for predicting clinical efficacy in experimental cancer chemotherapy.
Yamashita
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D000818:Animals; D002085:Butylhydroxybutylnitrosamine; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D005260:Female; D009368:Neoplasm Transplantation; D051381:Rats; D011912:Rats, Inbred ACI; D012867:Skin; D001743:Urinary Bladder; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*
D002085:Butylhydroxybutylnitrosamine