[Metabolic and ionic dependence of neuronal responses evoked by serotonin in the rat sensory ganglia].
The membrane potential and conductance alterations of rat dorsal root ganglion neurons evoked by serotonin applied in bath or from a micropipette under pressure have been studied by intracellular technique. Serotonin application evoked depolarization with a decrease in membrane conductance and hyperpolarization with an increase in its conductance. A part of depolarization responses mediated by 5-HT2 receptor activation were independent of intracellular AMP concentration and associated with blockade of M-current channels. The other part of depolarizing and all hyperpolarizing responses mediated by 5-HT1A receptor activation were depressed by pertussis toxin and considerably modulated by intracellular AMP alterations. These responses were shown to be associated with disturbances in the function of AMP-dependent potassium ionic channels.
Abramets
I I
II
Komissarov
I V
IV
Samoĭlovich
I M
IM
D000249:Adenosine Monophosphate / Q000378:metabolism; D000818:Animals; D003042:Cocaine / Q000494:pharmacology; D005727:Ganglia, Spinal / Q000187:drug effects / Q000502:physiology*; D008784:Methysergide / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D037342:Pertussis Toxin; D015221:Potassium Channels / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D010566:Virulence Factors, Bordetella / Q000378:metabolism
D015221:Potassium Channels; D011985:Receptors, Serotonin; D010566:Virulence Factors, Bordetella; D012701:Serotonin; D000249:Adenosine Monophosphate; D011433:Propranolol; D037342:Pertussis Toxin; D003042:Cocaine; D008784:Methysergide
Metabolicheskaia i ionnaia zavisimost' vyzyvaemykh serotoninom otvetov neĭronov sensornykh gangliev krys.