[Cumene hydroperoxide changes the type of conductivity of the mitochondrial membrane for K+].
The release of K+ from mitochondria under hypotonic conditions is a non-electrogenic process with an activity maximum at alkaline values of pH. Under these conditions an addition of cumene hydroperoxide causes the appearance of a second K+ release maximum at acidic pH values. The stimulation of K+ release by cumene hydroperoxide is accompanied by a decrease of the transmembrane potential and the accumulation of lipid peroxidation products. The effects of cumene hydroperoxide are prevented by the free radical scavenger, ionol. The acceleration of K+ release is not due to the activation of the non-electrogenic mechanism. It is concluded that the cumene hydroperoxide-induced release of K+ is caused by an increase in the nonspecific ionic permeability of the inner mitochondrial membrane and is controlled by free radical reactions. The contribution of K+ permeability of both types to the hormone-induced changes in the ionic composition of the mitochondrial matrix is discussed.
Novgorodov
S A
SA
Gudz'
T I
TI
Mor
Iu E
IuE
Goncharenko
E N
EN
Iaguzhinskiĭ
L S
LS
D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007425:Intracellular Membranes / Q000378:metabolism* / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D008930:Mitochondria, Liver / Q000378:metabolism* / Q000502:physiology; D011188:Potassium / Q000378:metabolism*; D051381:Rats
D001555:Benzene Derivatives; D002084:Butylated Hydroxytoluene; C007164:cumene hydroperoxide; D011188:Potassium
Gidroperekis' kumola izmeniaet tip provodimosti mitokhondrial'noĭ membrany dlia K+.