Hypertrophy and hyperplasia of the rat pancreas produced by short-term dietary administration of soya-derived protein and soybean trypsin inhibitor.
Feeding soy protein concentrate to weanling rats over a one-week period produced a dose-related increase in pancreatic weight due to an increase in acinar cell size. Hyperplastic changes occur simultaneously, as evidenced by an increase in mitotic activity after two days on the test diet. Similar changes were also obtained by feeding soybean Kunitz trypsin inhibitor over the same time period. The results suggest that this approach may be useful as a model to investigate the effect of plant-derived material on the pancreas, in particular proliferative lesions.
Smith
J C
JC
Food Safety Research Unit, Western Regional Research Center, USDA-ARS, Albany, CA 94710.
Wilson
F D
FD
Allen
P V
PV
Berry
D L
DL
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D004032:Diet; D006965:Hyperplasia; D006984:Hypertrophy; D008297:Male; D008938:Mitosis / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects / Q000473:pathology*; D014674:Plant Proteins, Dietary / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D030262:Soybean Proteins; D014360:Trypsin Inhibitor, Kunitz Soybean / Q000633:toxicity*; D014361:Trypsin Inhibitors / Q000633:toxicity*
D014674:Plant Proteins, Dietary; D030262:Soybean Proteins; D014361:Trypsin Inhibitors; D014360:Trypsin Inhibitor, Kunitz Soybean