title: [Disorders of immune system function and their correction in melanomas with regional metastases].
abstract: Dysfunction of the thymus and the immune system in patients with melanoma was shown to be in direct correlation with tumor extent. The use of thymosin-like immunomodulator was followed by the most apparent recovery of the parameters studied in patients with localized melanoma resulting in improved clinical course of the disease. In cases of tumor spread into regional lymph nodes, immunologic disorders observed were identical to those registered prior to treatment. Tumor did not disseminate in patients retaining normal immune status.
authors.forename: I F
authors.initials: IF
authors.lastname: Labunets
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Grinevich
authors.forename: B A
authors.initials: BA
authors.lastname: Tolstopiatov
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D000917:Antibody Formation / Q000187:drug effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D007107:Immune System / Q000187:drug effects / Q000276:immunology*; D007111:Immunity, Cellular / Q000187:drug effects; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000276:immunology* / Q000628:therapy; D008875:Middle Aged; D011182:Postoperative Care; D012878:Skin Neoplasms / Q000276:immunology* / Q000628:therapy; D013154:Spleen / Q000276:immunology; D013946:Thymopoietins / Q000627:therapeutic use; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D013946:Thymopoietins; C032841:thymopoietin III
vernacular_title: Narusheniia funktsiĭ immunnoĭ sistemy i ikh korrektsiia pri melanomakh s regionarnymi metastazami.