[Changes in local blood flow in the solitary kidney after chronic blockade of cholinergic mediation].
The method of hydrogen clearance has been used to study the influence of compensatory hypertrophy and continuous 120-day pharmacologic blockade of parasympathetic nerves by atropine on interorgan peritubular blood circulation of the Wistar line rat kidneys. Reliable "lagging" of the cortical blood flow behind the analogous values of the control group with a single kidney is noted. Decrease of the cortex perfusion under conditions of cholinergic blockade is due to "baring" of the high sympathogenic tonus of cortical vessels in spite of postnephrectomic hyperperfusion in the control. A conclusion is made concerning significance of cholinergic mediation in development of compensatory hypertrophy of a single kidney in syndrome of its denervation impairment.
Barinov
E F
EF
Kot
A G
AG
D000818:Animals; D001285:Atropine; D001340:Autonomic Nerve Block; D002799:Cholinergic Fibers / Q000187:drug effects*; D007668:Kidney / Q000098:blood supply / Q000294:innervation*; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D012079:Renal Circulation; D013997:Time Factors
D001285:Atropine
Izmeneniia lokal'nogo krovotoka edinstvennoĭ pochki pri khronicheskoĭ blokade kholinergicheskoĭ mediatsii.