title: Intractible cutaneous non-Hodgkin's lymphoma of the lower limb. Complete remission after sequential regional isolated hyperthermic perfusion and perfusion with 1-phenylalanine-mustard (melphalan, L-Pam).
abstract: A 61-year-old man with an intractible and progressively disabling cutaneous non-Hodgkin's lymphoma (NHL) in the lower limb was treated with sequential regional isolated perfusion at 10-day intervals. The first perfusion was hyperthermic (40.2-43.1 degrees C tumor-temperature); the second was at controlled normothermia with high-dose 1-phenylalanine mustard (melphalan, L-Pam; 11 mg/l perfused tissue). This treatment resulted in a complete remission in the perfused area of significant duration and has prevented amputation.
authors.affiliation: Department of Surgical Oncology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
authors.forename: R F
authors.initials: RF
authors.lastname: Jansen
authors.forename: B N
authors.initials: BN
authors.lastname: van Geel
authors.forename: J
authors.initials: J
authors.lastname: van der Zee
authors.forename: A
authors.initials: A
authors.lastname: Hagenbeek
authors.forename: P C
authors.initials: PC
authors.lastname: Levendag
mesh_terms: D010478:Chemotherapy, Cancer, Regional Perfusion; D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced; D007866:Leg; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy*; D008297:Male; D008558:Melphalan / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D012878:Skin Neoplasms / Q000628:therapy*
chemical_list: D008558:Melphalan