[The effect of Chinese teas on the occurrence of oesophageal tumor caused by N-nitrosomethylbenzylamine in rats].
Five groups of rats were given different varieties of Chinese tea as drinking water and on additional two groups of rats were given water with or without N-nitrosomethylbenzylamine (NMBzA) as controls. Except the control group, all the animals were intubated with NMBzA (5 mg.kg-1/wk) for 6 or 12 weeks. After 6 weeks, the incidence of oesophageal mucosa lesions was significantly lower in the tea-treated rats (16-59%) than the control group with NMBzA (100%). After 12 weeks, the incidence of oesophageal tumor was also significantly lower in the tea-treated groups (42-67%) than the control group with NMBzA (90%). Similar results were obtained in the tumor size and the number of tumors developed. The anti-carcinogenic effects of the 5 varieties of Chinese tea were also not the same the Fujian Oolong tea and Jasmine tea had the strongest effect. The results suggest that Chinese tea can inhibit the carcinogenesis caused by N-nitroso compound.
Han
C
C
Xu
Y
Y
D000818:Animals; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013662:Tea
D013662:Tea; C014707:nitrosobenzylmethylamine; D004128:Dimethylnitrosamine