[Acute myocardial infarct: aspects of changed mortality at the intensive care unit. Results of a prospective study from 1985 to 1987].
Between 1975 and 1987 the mortality rate among 3143 patients with acute myocardial infarction admitted to an intensive care unit fell from 25% to below 10%. Among 829 patients examined prospectively during three consecutive years, the rate was 12.5% in 1985, 13.1% in 1986, and 9.3% in 1987 (mean of 11.6%). In addition to higher age, other risk factors were identified (mortality in brackets): female sex (14.6%), heart failure (20.6%), and diabetes (19.7%). Hypertension (11.2%) and previous infarct (12.8%) had no influence on mortality rate. The mortality rate was significantly reduced (P less than 0.0003) among 290 patients who had received intravenous fibrinolytic treatment, but this effect was marked only among women, elderly patients and those without risk factors. It is concluded that many measures had led to the observed reduction in acute death rate to about 10%. It is not yet possible to determine which of the different interventions played a part.
Schäfer
J H
JH
Medizinische Klinik und Poliklinik, Freie Universität Berlin.
Maurer
A
A
Arntz
H R
HR
Heitz
J
J
Jochimsen
F
F
Kernn
H
H
Schröder
R
R
D000367:Age Factors; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D005860:Germany, West; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy / Q000401:mortality*; D011446:Prospective Studies; D012737:Sex Factors
D005343:Fibrinolytic Agents
Akuter Myokardinfarkt: Aspekte der veränderten Sterblichkeit auf der Intensivstation. Ergebnisse einer prospektiven Untersuchung der Jahre 1985 bis 1987.