title: Linkage analysis with inbreeding.
abstract: For computational reasons, linkage analysis of highly inbred pedigrees is often performed under the assumption that spouse pairs are genetically unrelated. A formulation of the likelihood of a pedigree which takes into account all of the genealogical information omega, for an arbitrary relationship between a pair of spouses, is proposed. Lod scores at a recombination fraction of 0 for an inbred three-member nuclear family are presented.
authors.affiliation: Department of Psychiatry, Washington University, St. Louis, MO.
authors.forename: P
authors.initials: P
authors.lastname: Van Eerdewegh
mesh_terms: D002648:Child; D003198:Computer Simulation; D003241:Consanguinity; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D010375:Pedigree