Translocation 3;21 in Philadelphia chromosome positive chronic myeloid leukemia at diagnosis.
We describe a further case of Philadelphia chromosome-positive chronic myeloid leukemia with a t(3;21)(q26.2;q22) present in the chronic phase. Blastic transformation occurred 8 months after presentation. The presence of the t(3;21) may indicate a poor prognosis.
Thompson
P W
PW
Department of Haematology, University of Wales College of Medicine, Cardiff, U.K.
Whittaker
J A
JA
D000328:Adult; D002891:Chromosomes, Human, Pair 21; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D015466:Leukemia, Myeloid, Chronic-Phase / Q000235:genetics*; D011379:Prognosis; D013997:Time Factors; D014178:Translocation, Genetic