New antihepatotoxic naphtho-pyrone glycosides from the seeds of Cassia tora.
Two new naphtho-pyrone glycosides, 9-[(beta-D-glucopyranosyl-(1----6)-O-beta-D-glucopyranosyl)oxy]-10- hydroxy-7-methoxy-3-methyl-1H-naphtho[2,3-c]pyran-1 -one (5) and 6-[(alpha-apiofuranosyl-(1----6)-O-beta-D-glucopyranosyl)oxy]- rubrofusarin (6), together with cassiaside (3) and rubrofusarin-6-beta-gentiobioside (4) were isolated from the seeds of Cassia tora L. Their structures were elucidated on the basis of chemical and spectral data. The naphtho-gamma-pyrone glycosides (3, 4, and 6) were found to have significant hepato-protective effects against galactosamine damage, which were higher than that of silybin from Silybum marianum.
Wong
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SM
Wong
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Seligmann
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O
Wagner
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D002366:Cassia / Q000032:analysis*; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006868:Hydrolysis; D008107:Liver Diseases / Q000188:drug therapy*; D008745:Methylation; D015394:Molecular Structure; D009284:Naphthols / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000032:analysis*; D011714:Pyrans / Q000494:pharmacology*; D011753:Pyrones / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet
D006027:Glycosides; D009284:Naphthols; D011714:Pyrans; D011753:Pyrones