title: Gallbladder function and fasting enterogastric bile reflux.
abstract: The relationship between gallbladder function and duodenogastric reflux of bile has been investigated in the fasting phase by 99Tcm-EHIDA biliary scintigraphy in 370 patients with abdominal pain. This isotope is cleared from the blood-pool by hepatocellular function and is excreted into the biliary tract. Obstruction of the common bile duct was found in 79 patients, leaving 291 who were evaluable for duodenogastric bile reflux. Gallblader function was present in 169 and absent in 122 patients. Duodenogastric reflux of bile was observed in 82 patients, 10 of whom had had previous gastric surgery. Only 298 of 169 (17%) patients with a functioning gallbladder showed evidence of enterogastric bile reflux compared to 43 of 122 (35%) with absent gallbladder function (p less than 0.005 by Chi Square). These results suggest that continuous bile flow into the duodenum in the absence of a functioning gallbladder facilitates duodenogastric reflux.
authors.affiliation: Department of Medical Physics, Ninewells Hospital & Medical School, Dundee.
authors.forename: N S
authors.initials: NS
authors.lastname: Kennedy
authors.forename: F C
authors.initials: FC
authors.lastname: Campbell
authors.forename: P T
authors.initials: PT
authors.lastname: Cullen
authors.forename: D G
authors.initials: DG
authors.lastname: Sutton
authors.forename: B W
authors.initials: BW
authors.lastname: Millar
authors.forename: A
authors.initials: A
authors.lastname: Cuschieri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001655:Bile Reflux / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging*; D004383:Duodenogastric Reflux / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D005215:Fasting; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007098:Imino Acids; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D011877:Radionuclide Imaging; D013667:Technetium; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid
chemical_list: D007098:Imino Acids; D009942:Organometallic Compounds; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid; D013667:Technetium