Comparative free-radical chemistry in the radiolytic deamination and dephosphorylation of bio-organic molecules. I. Oxygen-free solutions.
A wide range of experimental data is evaluated in support of the hypothesis that the reductive deamination of amino acids and peptides by eaq- and the oxidative dephosphorylation of glycol phosphates by OH in oxygen free solution are related in terms of a common elimination reaction involving free-radical intermediates of the same genre, that is, XCH(R)C(OH)R----HX + CH(R)COR where X = NH2, RCONH, and H2PO4 respectively. The proposed reaction model unifies for the first time the basic free-radical chemistry of N-C and PO-C bond cleavage in the radiolysis of peptides and glycol phosphates including proteins and nucleic acids in oxygen-free solution.
Garrison
W M
WM
University of California, Berkeley, Lawrence Berkeley Laboratory, CA 94720.
D000596:Amino Acids / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D005609:Free Radicals; D006018:Glycols / Q000378:metabolism; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010455:Peptides / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D010766:Phosphorylation; D011675:Pulse Radiolysis; D012996:Solutions
D000596:Amino Acids; D005609:Free Radicals; D006018:Glycols; D010455:Peptides; D010710:Phosphates; D012996:Solutions