Myelodysplastic syndrome with trisomy 11 associated with polycythemia vera.
A 52-year-old male with myelodysplastic syndrome (MDS) who had a prior history of polycythemia vera is reported. Chromosome analysis revealed that the bone marrow and blood cells at the MDS phase contained trisomy of chromosome 11 as the sole cytogenetic change. Trisomy 11 is rarely found in hematologic neoplasia, and all of the reported cases with trisomy 11 were diagnosed as having nonlymphocytic neoplasia. In this report, a correlation between the chromosome change and leukemia/MDS developed in polycythemia vera is discussed.
Ohyashiki
K
K
First Department of Internal Medicine, Tokyo Medical College, Japan.
Nagasu
M
M
Hojo
H
H
Iwabuchi
A
A
Ohyashiki
J H
JH
Toyama
K
K
D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000235:genetics / Q000473:pathology; D011087:Polycythemia Vera / Q000150:complications*; D014314:Trisomy