Effect of polar-planar compounds on the differentiation of normal human myeloid immature marrow cells.
Polar-planar compounds which are potent differentiating agents, have been reported to enhance the response of friend erythroleukaemic cells and other malignant cell lines to mitomycin C, cis-platinum and radiation. With the upcoming of phase II clinical trials of these polar compounds alone and in combination with cytotoxic agents, the effect of 3 polar compounds: dimethylsulphoxide, dimethylformamide and hexamethylene bisacetamide on the differentiation of normal human myeloid immature marrow cells was studied. The results showed that a long-term exposure to these polar compounds may lead to a premature senescence of these marrow progenitors.
Hassan
H T
HT
Department of Haematological Medicine, University of Cambridge Clinical School, U.K.
Rees
J K
JK
D000081:Acetamides / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004126:Dimethylformamide / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D013329:Structure-Activity Relationship; D013778:Tetrazolium Salts
D000081:Acetamides; D013778:Tetrazolium Salts; C042207:4-anisyltetrazolium blue; D004126:Dimethylformamide; C014026:hexamethylene bisacetamide; D004121:Dimethyl Sulfoxide