Acute and chronic effects of the trichothecene mycotoxin T-2 on rat brain regional concentrations of serotonin, tryptophan, and tyrosine.
Female rats were given 1 acute dose or chronic doses (once every 48 hr for 28 days) of T-2 toxin (10 micrograms/kg ip) or vehicle. At necropsy, each brain was subdivided into cerebellum, cerebral cortex (including telencephalon and diencephalon), and brainstem (including mesencephalon, metencephalon, and myelencephalon). Acute systemic T-2 toxin administration increased cerebellar and brainstem tryptophan while serotonin, a tryptophan metabolite, was decreased correspondingly in these same brain regions. Chronic T-2 administration increased cerebellar tyrosine and serotonin concentrations, while cortical tryptophan concentrations were also increased. These results indicate that both acute and chronic administration of T-2 toxin cause differential changes in regional distribution levels of tyrosine, tryptophan, and serotonin.
Weekley
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LB
School of Veterinary Medicine, Colorado State University, Fort Collins 80523.
O'Rear
C E
CE
Kimbrough
T D
TD
Llewellyn
G C
GC
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis*; D012717:Sesquiterpenes / Q000633:toxicity*; D013605:T-2 Toxin / Q000633:toxicity*; D014364:Tryptophan / Q000032:analysis*; D014443:Tyrosine / Q000032:analysis*
D012717:Sesquiterpenes; D012701:Serotonin; D014443:Tyrosine; D014364:Tryptophan; D013605:T-2 Toxin