[The pharmacokinetics of the antitumor preparation of dimetinur].
The pharmacological disposition of 1,3-dimethyl-1-nitrosourea (dimetinur) in intact rats and animals with Walker carcinosarcoma, glioma 2211, colon adenocarcinoma was studied by the colorimetric assay using an oral drug dose of 100 mg/kg. Computer analysis of data was based on a single-compartment model using the area under the concentration-time curve (S) and the intact drug half-life (t1/2) as main pharmacokinetic parameters. The highest level of the drug (S) was observed in tumour and brain tissues on an equality with drug distribution between blood, spleen, kidney and lungs. The half-life of the dimetinur removal from blood exceeds the known values for certain active NAM type. The antitumour activity of the drug against the studied tumours correlates positively with pharmacokinetic parameters for the tumours (S and 1/tmax).
Ostrovskaia
L A
LA
Rykova
V A
VA
Konradov
A A
AA
Ivanov
A S
AS
Korman
D B
DB
D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis / Q000493:pharmacokinetics*; D003124:Colorimetry; D006207:Half-Life; D008770:Methylnitrosourea / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D000970:Antineoplastic Agents; C001049:N,N'-dimethylnitrosourea; D008770:Methylnitrosourea
Farmakokinetika protivoopukholevogo preparata dimetinur.