title: [Cytochrome P-450 dependent drug metabolism--use of an in vitro test system in multiple chemical exposure].
abstract: Investigations of the influence of an actual exposure on the in-vitro-activities and the inducibility of cytochrom P-450 dependent enzymes have not been described in the literature until now. First results gained from mitogen-stimulated lymphocytes of exposed and not-exposed individuals suggest such an influence of the given mixture of noxious agents on the basic deethylational ability of the examined cells acting in the sense of inhibition. Possible causes for this phenomenon are discussed.
authors.forename: R
authors.initials: R
authors.lastname: Skölziger
authors.forename: G
authors.initials: G
authors.lastname: Wagner
authors.forename: J
authors.initials: J
authors.lastname: Damrau
authors.forename: C
authors.initials: C
authors.lastname: Beyer
authors.forename: W
authors.initials: W
authors.lastname: Wohlrab
authors.forename: H
authors.initials: H
authors.lastname: Uhlig
mesh_terms: D000395:Air Pollutants, Occupational / Q000493:pharmacokinetics*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction; D005260:Female; D008658:Inactivation, Metabolic; D008214:Lymphocytes / Q000201:enzymology; D008297:Male
chemical_list: D000395:Air Pollutants, Occupational; D003577:Cytochrome P-450 Enzyme System
vernacular_title: Cytochrom P-450-abhängige Fremdstoffmetabolisierung--Anwendung eines in-vitro-Testsystems bei chemischer Mehrfachexposition.