N-oxidation, O-demethylation, and excretion of trimethoprim by the turtle Pseudemys scripta elegans.
Trimethoprim was excreted within one hour after being given orally to the turtle Pseudemys scripta elegans. No O-demethylated or N-oxide metabolites were detected.
Vree
T B
TB
Department of Clinical Pharmacy, Sint Radboud University Hospital, Nijmegen, The Netherlands.
Vree
J B
JB
Kolmer
E B
EB
Hekster
Y A
YA
Nouws
J F
JF
Shimoda
M
M
D000284:Administration, Oral; D000818:Animals; D003640:Dealkylation; D010084:Oxidation-Reduction; D014295:Trimethoprim / Q000008:administration & dosage / Q000378:metabolism*; D014426:Turtles / Q000378:metabolism*
D014295:Trimethoprim