title: Thyroxine-induced redistribution of creatine kinase isoenzymes in rat cardiomyocyte cultures.
abstract: The present study demonstrates a change occurring in the creatine-kinase isoenzyme profile of cardiomyocyte cultures induced by a chronic administration of excessive amounts of thyroid hormones (TH). This change is manifested by an increased level of the CK-BB isoenzyme, generally at the expense of CK-MM isoenzyme. The elevation of CK-BB is probably a result of a specific effect of TH through activation of gene expression, rather than a contribution of an increased number of non-myocardial cells. The implications of these results in the diagnosis of heart failures are discussed.
authors.affiliation: Bar-Ilan University, Department of Life Sciences, Ramat-Gan, Israel.
authors.forename: H
authors.initials: H
authors.lastname: Brik
authors.forename: L
authors.initials: L
authors.lastname: Alkaslassi
authors.forename: D
authors.initials: D
authors.lastname: Harell
authors.forename: O
authors.initials: O
authors.lastname: Sperling
authors.forename: A
authors.initials: A
authors.lastname: Shainberg
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003402:Creatine Kinase / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D007527:Isoenzymes; D009203:Myocardial Infarction / Q000175:diagnosis; D009206:Myocardium / Q000166:cytology / Q000201:enzymology*; D051381:Rats; D013974:Thyroxine / Q000502:physiology*; D014284:Triiodothyronine / Q000502:physiology*
chemical_list: D007527:Isoenzymes; D014284:Triiodothyronine; D003402:Creatine Kinase; D013974:Thyroxine