Lipid peroxidation in normal and ulcerated gastric mucosa of rats treated with pentacaine and cimetidine.
Gastric mucosal damage caused by the administration of ulcerogenic agents resulted in different changes in lipid peroxidation. An increase in malondialdehyde level was observed after ethanol exposure, whereas suppression of lipid peroxidation occurred after dosing with indomethacin. Changes in lipid peroxides associated with ethanol- but not indomethacin-induced injury were prevented by pretreatment with pentacaine and cimetidine.
Nosálová
V
V
Centre of Physiological Sciences, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Petríková
M
M
Nosál
R
R
D000818:Animals; D002219:Carbamates / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D000431:Ethanol; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D007213:Indomethacin; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control
D002219:Carbamates; D000431:Ethanol; D008315:Malondialdehyde; C010618:pentacaine; D002927:Cimetidine; D007213:Indomethacin