title: The risk factors for ischemic heart disease in Tibetan highlanders.
abstract: The risk factors for ischemic heart disease (IHD) in 35 Tibetan highlanders were investigated and compared with those in 30 age- and sex-matched healthy Japanese controls. Although Tibetans had remarkably high hematocrit values, and a decrease of eicosapentaenoic acid in both serum total lipids and serum phospholipid (PL) possibly due to their diet, they were considered to have a low incidence of IHD from our door-to-door study. These positive risk factors are likely counteracted by other negative risk factors as follows; Tibetans rarely exhibited systolic hypertension, and had lower levels of serum cholesterol and serum apolipoprotein (apo) B, and apo B/apo A-I ratio. In addition, Tibetan highlanders showed a decreased level of palmitic acid and an increased level of linoleic acid in serum PL which may protect against atherosclerosis.
authors.affiliation: Department of Neurology, Medical Center for Adult Diseases, Shiga, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Fujimoto
authors.forename: K
authors.initials: K
authors.lastname: Matsubayashi
authors.forename: T
authors.initials: T
authors.lastname: Miyahara
authors.forename: A
authors.initials: A
authors.lastname: Murai
authors.forename: M
authors.initials: M
authors.lastname: Matsuda
authors.forename: H
authors.initials: H
authors.lastname: Shio
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Kameyama
authors.forename: A
authors.initials: A
authors.lastname: Saito
authors.forename: L
authors.initials: L
authors.lastname: Shuping
mesh_terms: D000531:Altitude / Q000009:adverse effects*; D001794:Blood Pressure; D002681:China; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000209:etiology*; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D005227:Fatty Acids; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol