[Monoclonal antibody NCC-ST-439 in gastric cancer tissue].
An immunohistochemical study revealed that NCC-ST-439 positive tumor were detected in 33% of the 244 gastric carcinomas. The incidence of NCC-ST-439 immunoactivity in well differentiated adenocarcinomas (papillary and tubular adenocarcinoma) was significantly higher than in poorly differentiated adenocarcinomas (including signet-ring cell and mucinous adenocarcinoma). Moreover, NCC-ST-439 immunoreactive tumors showed more frequent vessel invasion and higher DNA content than non-reactive tumors. The recurrence rates of NCC-ST-439 immunoreactive tumors in the liver and lymph nodes were significantly higher than those of non-reactive tumors. Patients with NCC-ST-439 immunoreactive carcinoma had much worse prognosis than those with NCC-ST-439 non-reactive carcinoma. These results suggest that NCC-ST-439 antigen produced by tumor cells plays an important role in the invasive growth and vessel invasion and also serves as a biological marker of malignancy in patients with gastric cancer.
Kamata
T
T
Second Department of Surgery, Kanazawa University School, Japan.
Yoneumura
Y
Y
Sugiyama
K
K
Yamaguchi
A
A
Miwa
K
K
Miyazaki
I
I
D000230:Adenocarcinoma / Q000276:immunology / Q000556:secondary; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002467:Cell Nucleus / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000276:immunology* / Q000401:mortality / Q000473:pathology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm