Testing a purified lanolin preparation by a randomized procedure.
Patients with a previous contact allergy to lanolin (wool alcohols and/or Amerchol L 101) were patch tested 1 to 4 years later with lanolin allergens, as well as purified anhydrous lanolin contained in a commercial cream. At this retest, only 20 out of 33 patients with a previous contact allergy to lanolin reacted to lanolin allergens, and only 1 to the purified lanolin (as is). None reacted to the commercial cream containing 6% purified lanolin, this being ascertained by patch test as well as by usage test. To avoid bias at reading, patch tests were applied in a randomized computer-based order and read blindly.
Edman
B
B
Department of Dermatology, Lund University, Malmö, Sweden.
Möller
H
H
D000485:Allergens / Q000302:isolation & purification; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007809:Lanolin / Q000009:adverse effects* / Q000302:isolation & purification; D010328:Patch Tests; D011897:Random Allocation
D000485:Allergens; D007809:Lanolin