Biosynthesis of benanomicins.
The biosynthesis of benanomicins A and B, produced by actinomycete strain MH193-16F4, was investigated by feeding experiments with 14C- and 13C-labeled compounds followed by measurement of radioactivity and 13C NMR analysis. A 2D double quantum coherence NMR spectrum of benanomicin A derived from sodium [1,2-13C2]acetate provided the location of intact acetate units, and confirmed the 13C assignments of benanomicins. The results indicate that the aglycone of benanomicins is derived from a dodecaketide, methionine and alanine.
Gomi
S
S
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
Sezaki
M
M
Hamada
M
M
Kondo
S
S
Takeuchi
T
T
D000192:Actinomycetales / Q000378:metabolism*; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D000935:Antifungal Agents / Q000096:biosynthesis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D000095643:Pradimicins and Benanomicins
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; C056805:benanomicin A; D000095643:Pradimicins and Benanomicins; C056806:benanomicin B