title: Metabolism and pharmacokinetic studies of propionylpromazine in horses.
abstract: The propionylpromazine concentrations in plasma after intramuscular administration to horses were determined using gas chromatography with nitrogen-phosphorus detection. After hydrolysis by beta-glucuronidase/arylsulphatase, the parent drug and three metabolites were detected in urine. The metabolites were identified as 2-(1-hydroxypropyl)promazine, 2-(1-propenyl)promazine and 7-hydroxypropionylpromazine by gas chromatography-mass spectrometry. No N-demethylated or sulphoxidated metabolites of propionylpromazine were observed in the horse urine.
authors.affiliation: Doping Control Centre, Korea Advanced Institute of Science and Technology, Seoul.
authors.forename: J
authors.initials: J
authors.lastname: Park
authors.forename: Y O
authors.initials: YO
authors.lastname: Shin
authors.forename: H Y
authors.initials: HY
authors.lastname: Choo
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas; D008401:Gas Chromatography-Mass Spectrometry; D006736:Horses; D011395:Promazine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics
chemical_list: D011395:Promazine; C026328:propionylpromazine