title: [Intraperitoneal administration of high doses of cisplatin in advanced ovarian carcinoma].
abstract: 42 patients with advanced ovarian carcinoma were treated with large doses of cis-DDP by the i.p. route. The toxic effects of platinum were reduced by the i.v. administration of thisulphate. Depending on age and the general condition of the patient, 200-270 mg cis-DDP were administered in one series. Ascites disappeared in 54.7% patients, partial remission of the tumour was achieved in 28.5%, complete histopathological remission confirmed by second look operation in 26.2% and in 21.4% the result was doubtful.
authors.forename: B
authors.initials: B
authors.lastname: Ptácková
authors.forename: J
authors.initials: J
authors.lastname: Kopecný
authors.forename: P
authors.initials: P
authors.lastname: Zatocil
authors.forename: M
authors.initials: M
authors.lastname: Anton
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use; D003536:Cystadenocarcinoma / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D002945:Cisplatin
vernacular_title: Intraperitoneální aplikace vysokých dávek cis-platiny u pokrocilého karcinomu ovaria.