Demonstration and quantitation of pharmacological inhibition of pulmonary uptake of N-isopropyl-123I-p-iodoamphetamine by propranolol.
The first-pass pulmonary extraction values of N-Isopropyl-123I-p-Iodoamphetamine (123I-IMP) in pretreated dogs decreases from 90 to 62% as the amount of propranolol increases from 0 to 20 mg. The first-pass pulmonary extraction values of 123I-IMP in dogs with a simultaneous bolus injection of propranolol decreases from 90 to 62% as the amount of propranolol increases from 0 to 10 mg. The pulmonary extraction of 123I-IMP with a simultaneous bolus injection of ketamine and 123I-IMP decreases from 90 to 64% as the ketamine dose increases from 0 to 100 mg. These results suggest that the pulmonary uptake of 123I-IMP may be at least partially mediated by receptors. They also indicate that endothelial metabolic cell function may be a useful index of early lung pathology. Furthermore, studies of the degree of lung uptake may be a sensitive index of pathologic states in which alterations of amine binding sites have occurred.
Akber
S E
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Division of Nuclear Medicine, UCLA School of Medicine.
D000662:Amphetamines / Q000493:pharmacokinetics*; D000818:Animals; D003864:Depression, Chemical; D004285:Dogs; D007457:Iodine Radioisotopes; D020367:Iofetamine; D007649:Ketamine / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*
D000662:Amphetamines; D007457:Iodine Radioisotopes; D007649:Ketamine; D011433:Propranolol; D020367:Iofetamine; D010646:Phentolamine