Translocation t(9;11)(p23;q12): a primary chromosomal change in renal oncocytoma.
We report the cytogenetic, clinical, radiological and pathological features of a renal oncocytoma, diagnosed accidentally in a 50-year-old man who originally presented with symptoms related to prostatic hyperplasia. All metaphases examined showed a structural chromosomal rearrangement t(9;11)(p23;q12) as the only change. The constitutional karyotype was established as 46XY. We believe that this karyotypic anomaly may represent a primary and possibly specific change characterizing this uncommon and generally benign type of tumor.
Walter
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TA
Cancer Center of Southwest Biomedical Research Institute, Scottsdale and Good Samaritan Medical Center, Phoenix, Arizona.
Pennington
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RD
Decker
H J
HJ
Sandberg
A A
AA
D000236:Adenoma / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic