title: The relationship between gastrin cells and bombesin-like immunoreactive nerve fibres in the gastric antral mucosa of guinea-pig, rat, dog and man.
abstract: The relationship between bombesin-like immunoreactive (bombesin-LI) nerve fibres and gastrin-LI G-cells was examined in gastric antral mucosa from guinea-pig, rat, dog and man using a double-labelling fluorescence immunohistochemical technique. The greatest density of bombesin-LI nerve fibres was found within the basal mucosa in all species and the density of innervation decreased towards the luminal surface. Most G-cells were in a band occupying approximately the middle third of the mucosa. The proportion of G-cells found within a distance of 2 microns from bombesin-LI nerve fibres was low in all species (6% in the guinea-pig, 22% in the rat, 14% in the dog, and 9% in the human). It is proposed that the neuropeptide released from bombesin-LI antral mucosal nerve fibres traverses distances of greater than several microns to reach the target G-cells. This may be achieved by passage through the mucosal microcirculation.
authors.affiliation: Department of Physiology, School of Medicine, Flinders University of South Australia, Bedford Park.
authors.forename: A S
authors.initials: AS
authors.lastname: Miller
authors.forename: J B
authors.initials: JB
authors.lastname: Furness
authors.forename: M
authors.initials: M
authors.lastname: Costa
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001341:Autonomic Nervous System / Q000166:cytology / Q000378:metabolism*; D001839:Bombesin / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000166:cytology / Q000294:innervation / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism*; D006168:Guinea Pigs; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D051381:Rats
chemical_list: D005755:Gastrins; D001839:Bombesin