Chronic treatment with amitriptyline produces subsensitivity to the hypothermic effects of yohimbine.
1. Two but not one week of treatment with amitriptyline (AMI) produces subsensitivity to the hypothermic effects of the alpha 2 antagonist yohimbine. 2. Subsensitivity persisted for the three weeks during which it was measured following the discontinuation of AMI. 3. Two weeks of twice daily injections of saline did not alter the thermic response to this agent. 4. The results support other data indicating tricyclic antidepressants (TCAs) subsensitize alpha 2 mediated thermic changes and are consistent with reports that TCAs down-regulate alpha 2 receptors.
Dilsaver
S C
SC
Department of Psychiatry, Ohio State University, Columbus.
Davidson
R K
RK
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004357:Drug Synergism; D007035:Hypothermia / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D015016:Yohimbine / Q000494:pharmacology*
D000639:Amitriptyline; D015016:Yohimbine