Cytogenetic effects of 3,4-dichloroaniline in human lymphocytes and V79 Chinese hamster cells.
3,4-Dichloroaniline (3,4-DCA), an intermediate in various chemical syntheses, has been detected as an environmental contaminant in surface waters and in the effluents from dye-manufacturing plants. Tested for clastogenicity in human lymphocytes in vitro the compound was inactive in the chromosome aberration assay yet exhibited a positive sister-chromatid exchange response in the presence of a mammalian metabolic activation system. Exposure of V79 Chinese hamster cells to 3,4-DCA caused a concentration-dependent increase in the incidence of spindle disturbances, predominantly of the initial c-mitotic type. The results indicate that 3,4-DCA might induce aneuploidy in mammalian cells by interaction with the mitotic apparatus.
Bauchinger
M
M
Institut für Strahlenbiologie, Gesellschaft für Strahlen-und Umweltforschung, Neuherberg/Munich, F.R.G.
Kulka
U
U
Schmid
E
E
D000814:Aniline Compounds / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D002869:Chromosome Aberrations / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects; D009152:Mutagenicity Tests; D009153:Mutagens / Q000493:pharmacokinetics; D012854:Sister Chromatid Exchange / Q000187:drug effects
D000814:Aniline Compounds; D009153:Mutagens; C014464:3,4-dichloroaniline