title: The antiarrhythmic activity of N-alkyl-1,2-diphenylethanolamines.
abstract: The activity of N-alkyl-1,2-diphenylethanolamines against CaCl2-induced cardiac arrhythmia was evaluated in the rat. The potencies of the compounds were compared with that of the established calcium ion-channel blocker, verapamil. The N-methyl, N-ethyl, and N-isobutyl derivatives as well as verapamil at doses of 2-8 mumols kg-1 protected the animals against the induced arrhythmia. The potency order was verapamil greater than N methyl greater than N-ethyl greater than N-isobutyl derivatives. The N-isopropyl and N-butyl derivatives were inactive. The antiarrhythmic activity of the compounds was not due to local anesthetic activity but may be caused by calcium-channel inhibition.
authors.affiliation: Department of Pharmacology, College of Pharmacy, King Saud University, Saudi Arabia.
authors.forename: K E
authors.initials: KE
authors.lastname: el Tahir
authors.forename: H A
authors.initials: HA
authors.lastname: al-Obeid
authors.forename: K A
authors.initials: KA
authors.lastname: al-Rashood
authors.forename: A A
authors.initials: AA
authors.lastname: Madani
authors.forename: A M
authors.initials: AM
authors.lastname: Ageel
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004983:Ethanolamines / Q000494:pharmacology*; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000494:pharmacology
chemical_list: D000889:Anti-Arrhythmia Agents; D004983:Ethanolamines; D008012:Lidocaine; D014700:Verapamil