title: Endoscopic endoprosthesis insertion following failure of cholecystojejunostomy in pancreatic carcinoma.
abstract: Sixteen patients in whom malignant biliary obstruction recurred after failure of cholecystojejunostomy had attempted relief of obstruction by endoscopic insertion of an endoprosthesis. This treatment was successful in 13 patients, although one required percutaneous insertion because of duodenal distortion and one required a combined percutaneous-endoscopic approach. Median survival after stenting was 3.5 months (range from 2 weeks to 16 months). Of the three treatment failures, two patients had external drainage only and one succumbed before further treatment could be attempted. There were two complications associated with the procedure (one small bile leak and one episode of cholangitis) but the 30-day mortality rate of 12.5 per cent was related to disease progression rather than the procedure. Endoscopic stent insertion may achieve further worthwhile palliation of jaundice after the failure of surgery to relieve malignant biliary obstruction.
authors.affiliation: Department of Gastroenterology, University College, London, UK.
authors.forename: J F
authors.initials: JF
authors.lastname: Dowsett
authors.forename: S R
authors.initials: SR
authors.lastname: Cairns
authors.forename: D
authors.initials: D
authors.lastname: Vaira
authors.forename: A A
authors.initials: AA
authors.lastname: Polydorou
authors.forename: A R
authors.initials: AR
authors.lastname: Hatfield
authors.forename: R C
authors.initials: RC
authors.lastname: Russell
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000328:Adult; D000368:Aged; D002768:Choledochostomy; D002779:Cholestasis / Q000601:surgery; D004322:Drainage; D004724:Endoscopy; D006801:Humans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications / Q000401:mortality / Q000601:surgery; D011379:Prognosis; D019736:Prostheses and Implants; D012008:Recurrence