Effect of anticancer drugs and hyperthermia on nasopharyngeal carcinoma cell line in vitro.
The therapeutic effects of 10 anticancer drugs on a cultured nasopharyngeal carcinoma (NPC) cell line were examined by tritiated thymidine incorporation-inhibition assay and growth inhibition assay by a microphotometric method. The NPC cell line was found to be heterogeneous in terms of sensitivity to these anticancer drugs. Therapeutic efficacies of selected drugs could be increased by either increasing the drug concentration or the time of exposure of cells to drugs. Short duration of hyperthermia alone was also effective in inhibiting cell growth. Combined hyperthermia and actinomycin D or vincristine sulfate are markedly cytotoxic for the NPC cells in vitro.
Ha
D K
DK
Institute of Radiology and Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Lau
W H
WH
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced; D009303:Nasopharyngeal Neoplasms / Q000628:therapy*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents