Behavioral and neurochemical effects of amfonelic acid on the spontaneously diabetic Wistar-BB rat: implications of impaired dopamine function.
1. The purpose of this study was to investigate the hypothesis that the Spontaneously Diabetic Wistar-BB Rat (SDR) would manifest an altered behavioral and neurochemical response to the indirect dopamine (DA) agonist amfonelic acid (AFA). 2. The insulin treated male SDR (3-4 months diabetic) and matched controls were monitored for locomotor, floor (horizontal and lateral displacement) and rearing activity. Catecholamines and metabolites were analyzed using HPLC-EC. 3. Results obtained indicated that the SDR: i) is less sensitive to the behavioral effects of AFA than the controls; ii) following AFA treatment (1.0 mg/kg) a significantly greater depletion of dopamine in the striatum, hypothalamus, midbrain and olfactory bulbs as well as striatal norepinephrine was observed in the SDR as compared to controls. These results implicate a dysfunctional biosynthetic capacity for DA in the SDR.
Ahmad
Q
Q
School of Psychology, University of Ottawa, Ontario, Canada.
Merali
Z
Z
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004298:Dopamine / Q000378:metabolism; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009268:Nalidixic Acid / Q000031:analogs & derivatives; D009287:Naphthyridines / Q000494:pharmacology*; D009928:Organ Specificity; D051381:Rats; D011913:Rats, Inbred BB; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*
D001679:Biogenic Amines; D009287:Naphthyridines; D009268:Nalidixic Acid; C006486:amfonelic acid; D004298:Dopamine