[The action of cyclosporin A (CSA) on glycogen synthesis processes in rats in vivo].
Cyclosporin A appears to act on type I diabetes. In rats it alters glucose digestion. The present study provides a more detailed analysis of the influence of this substance on certain aspects of carbohydrate metabolism. The data reveal that CSA increases the glycogen in the liver and muscle but reduces the amount in the heart. Blood sugar was also significantly increased but only after the third dose of CSA. While these preliminary results clearly show that CSA has an effect on carbohydrate metabolism they do not indicate whether is the drug itself or one of the hormones that usually influence carbohydrate exchange which has this effect.
Hopps
V
V
Università di Palermo.
Vetri
P
P
Woodrow
M E
ME
Galione
A
A
Sorrentino
M C
MC
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003524:Cyclosporins / Q000494:pharmacology*; D005215:Fasting; D006003:Glycogen / Q000096:biosynthesis*; D006321:Heart / Q000187:drug effects; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008112:Liver Glycogen / Q000096:biosynthesis*; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D051381:Rats; D013997:Time Factors
D001786:Blood Glucose; D003524:Cyclosporins; D007773:Lactates; D008112:Liver Glycogen; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid; D006003:Glycogen
Azione della ciclosporina A (CSA) sui processi glicogenosintetici nei ratti "in vivo".