title: The use of gas chromatography/negative ion chemical ionization mass spectrometry for the determination of lorazepam in whole blood.
abstract: The determination of lorazepam in blood by gas chromatography/mass spectrometry with selected ion monitoring (GC/MS/SIM) in the negative chemical ionization mode (NICI) was investigated. The method involves a single extraction with Amberlite XAD-2 resin and the use of [2H6]triazolam as an internal standard. The limit of detection is 0.5 ng/mL and standard curves are linear from 6.25 to 250 ng/mL. The applicability of the method to forensic toxicology is reported.
authors.affiliation: Centre of Forensic Sciences, Toronto, Ontario, Canada.
authors.forename: E M
authors.initials: EM
authors.lastname: Koves
authors.forename: B
authors.initials: B
authors.lastname: Yen
mesh_terms: D000368:Aged; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D008140:Lorazepam / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D008140:Lorazepam