[Kidney function in the course of compensatory hypertrophy following unilateral nephrectomy in the Wistar rat].
Unilateral nephrectomy was performed in 109 male Wistar rats, 35 animals served as controls. Determinations of glomerular filtration rate (GFR) using slope clearance of 99mTc-DTPA and of tubular function using an orally water-loading test were made. The tests were performed 2 and 5 days as well as 2, 4, 5 and 6 weeks after nephrectomy. In all examinations the GFR was more than 50% of the level of two-kidney control animals. Fractional maximum diuresis was increased in the first 2 examinations after nephrectomy from 8.9 +/- 2.1 to 15.4 +/- 4.2% of the GFR and fractional clearance of osmotically free water from 6.8 +/- 1.9 to 10.9 +/- 3.5%. In the fourth and sixth week the proximal tubular reabsorption was increased and the glomerulo-tubular balance had been recovered. However, the minimal urine osmolarity was increased to 107.8 +/- 17.7 mmol/l and the osmotic load of the nephrons remained elevated. Possible clinical implications of the results are discussed.
Hagemann
J
J
Klinik für Innere Medizin Theodor Brugsch, Bereiches Medizin der Humboldt-Universität zu Berlin.
Pietsch
R
R
Kruse
I
I
Flemming
B
B
Weinmeister
S
S
Schmidt
I
I
Strangfeld
D
D
Schürer
M
M
Siewert
H
H
D000818:Animals; D001794:Blood Pressure; D005919:Glomerular Filtration Rate; D006984:Hypertrophy; D007668:Kidney / Q000473:pathology*; D007671:Kidney Concentrating Ability; D007677:Kidney Function Tests; D008297:Male; D009392:Nephrectomy; D009929:Organ Size; D011183:Postoperative Complications / Q000473:pathology*; D051381:Rats; D014508:Urea / Q000652:urine
D014508:Urea
Nierenfunktion im Verlauf der kompensatorischen Hypertrophie nach einseitiger Nephrektomie von Wistarratten.