title: Comparative effects of roxithromycin and erythromycin on cellular immune functions in vitro. 2. Chemotaxis and phagocytosis of 3H-Staphylococcus aureus by human macrophages.
abstract: The in vitro effects of roxithromycin on human macrophage activity were compared with those of erythromycin. Half the MIC of roxithromycin significantly enhanced the phagocytosis of 3H-labelled Staphylococcus aureus by human macrophages. Bacterial phagocytosis was also increased after pre-incubation of staphylococci with roxithromycin. Erythromycin displayed a less stimulating effect. Pre-incubation of macrophages with the drugs caused a depression of staphylococcal uptake by phagocytes. Macrophage chemotaxis was unchanged in the presence of both macrolides.
authors.affiliation: Institute of Microbiology, University of Turin, Italy.
authors.forename: N A
authors.initials: NA
authors.lastname: Carlone
authors.forename: A M
authors.initials: AM
authors.lastname: Cufini
authors.forename: V
authors.initials: V
authors.lastname: Tullio
authors.forename: D
authors.initials: D
authors.lastname: Sassella
mesh_terms: D002633:Chemotaxis / Q000187:drug effects; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007933:Leucomycins / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000276:immunology*
chemical_list: D007933:Leucomycins; D004917:Erythromycin