[Studies of animal experiment models of the behavior of the glomerular filtration rate in acute changes of dietary protein consumption].
The glomerular filtration rate (GFR) and the tubulo-secretoric transport maximum of para-aminohippuric acid (TmPAH) were examined in acute feeding trials (pellets, flesh) and after infusion of furesemide, dopamin and glucagon in normal and unilaterally nephrectomized Wistar rats. The aim of the study was to investigate the start process of GFR rise in a further experimental model (apart from the hyperfiltration in residual nephrons) and to confirm the so-called paradoxical GFR changes. The investigations of acute protein-loading induced GFR changes were without results, whereas a GFR rise could observed during intraarterial infusion of isotonic saline solution. A paradoxical GFR behaviour was demonstrable under high glucagon application.
Wüstenberg
P W
PW
Abteilung Pathophysiologie des Bereiches Medizin der Wilhelm-Pieck-Universität Rostock.
Chol
H
H
Schröder
J
J
Nitschke
F P
FP
Klinkmann
H
H
D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage*; D004298:Dopamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D005919:Glomerular Filtration Rate / Q000187:drug effects; D005934:Glucagon / Q000494:pharmacology; D007262:Infusions, Intravenous; D007684:Kidney Tubules / Q000378:metabolism; D009392:Nephrectomy; D051381:Rats; D010130:p-Aminohippuric Acid / Q000493:pharmacokinetics
D004044:Dietary Proteins; D005665:Furosemide; D005934:Glucagon; D004298:Dopamine; D010130:p-Aminohippuric Acid
Tierexperimentelle Modellstudien zum Verhalten der glomerulären Filtrationsrate (GFR) bei akuter Anderung des Nahrungsproteinangebotes.