title: 5-year survival of patients with periaortic nodal metastases in clinical stage IB and IIA cervical carcinoma.
abstract: From 1969 to 1981 thirty-six patients with stage IB and IIA cervical carcinoma were identified at pretherapy surgical staging laparotomy with histologically documented metastatic disease to the periaortic lymph nodes. All patients underwent a periaortic node dissection and all patients completed a course of extended-field radiotherapy in a postoperative setting. No major radio-therapeutic complications were encountered. The 5-year actuarial survival rate was 50%, with a median survival time of 29 months. The median time to recurrence was 10 months, while the median duration of survival following a recurrence was 7 months. Seventy-five percent of all recurrences occurred at distant sites. These data demonstrate that survival may be favorably influenced by employing extended-field radiotherapy in those patients with early-clinical-stage cervical cancer and periaortic nodal metastases. The subsequent development of distant metastases after such a treatment regimen emphasizes the need for adjuvant cytotoxic chemotherapy to enhance overall survival.
authors.affiliation: Department of Obstetrics and Gynecology, University of Miami School of Medicine, Florida 33101.
authors.forename: J L
authors.initials: JL
authors.lastname: Lovecchio
authors.forename: H E
authors.initials: HE
authors.lastname: Averette
authors.forename: D
authors.initials: D
authors.lastname: Donato
authors.forename: J
authors.initials: J
authors.lastname: Bell
mesh_terms: D002277:Carcinoma / Q000401:mortality* / Q000628:therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D002583:Uterine Cervical Neoplasms / Q000401:mortality* / Q000628:therapy