title: [Modeling of dose-response relations in exposure-related changes of the locomotor system].
abstract: Methodical aspects of designing and evaluation of epidemiological studies in occupational health research concerning chronical damages were discussed and illustrated by a study, which shows an essential dependence of arthrotical changes in the knee-joint from age and the intensity of kneeling stress. It is important for both design and evaluation, to regard relevantly the period of exposure. Dose-response relations can be simple proved and well described by regression analysis. Methods like score regression and cumulative logistic regression are very suitable for medical findings with rank categorial levels.
authors.forename: G
authors.initials: G
authors.lastname: Enderlein
authors.forename: J
authors.initials: J
authors.lastname: Kasch
mesh_terms: D006801:Humans; D007719:Knee Joint / Q000503:physiopathology*; D009784:Occupational Diseases / Q000503:physiopathology*; D010003:Osteoarthritis / Q000503:physiopathology*; D013312:Stress, Physiological / Q000150:complications*
vernacular_title: Modellierung von Dosis-Wirkungsbeziehungen für expositionsabhängige Veränderungen am Bewegungsapparat.