title: [A study of enzymatic hydrolysis of splenopentin and its analogs in human serum].
abstract: Degradation of immunoactive peptide splenopentin and its analogue N-acetylsplenopentin in human serum has been investigated by 1H NMR spectroscopy. It is shown that degradation of splenopentin occurs due to hydrolysis of peptide bonds in its N-terminal part, whereas in N-acetylsplenopentin peptide bonds in C-terminal part of the molecule are cleaved. Degradation pathways and life times of these peptides in human serum are established.
authors.forename: O L
authors.initials: OL
authors.lastname: Isakova
authors.forename: N F
authors.initials: NF
authors.lastname: Sepetov
authors.forename: K
authors.initials: K
authors.lastname: Forner
authors.forename: A
authors.initials: A
authors.lastname: Erlikh
mesh_terms: D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D010446:Peptide Fragments / Q000097:blood / Q000378:metabolism*; D010455:Peptides; D013946:Thymopoietins / Q000097:blood / Q000378:metabolism*; D013951:Thymus Hormones / Q000378:metabolism*
chemical_list: D010446:Peptide Fragments; D010455:Peptides; D013946:Thymopoietins; D013951:Thymus Hormones; C060358:N-acetylsplenopeptin; C041898:splenopentin
vernacular_title: Issledovanie fermentativnogo gidroliza splenopentina i ego analogov v syvorotke krovi chekloveka.