Mosaicism of 46,XX/47,XX,+9/47,XX,+?mar in the same amniotic fluid with apparent loss of one cell line after delivery.
A 46,XX;47,XX,+9;47,XX,+?mar karyotype was detected in an amniotic fluid cell culture and confirmed in a subsequent fetal blood sample from a 40-year-old woman. After termination of the pregnancy, none of the 186 mitoses obtained from a second blood sample was trisomic for chromosome 9 (p less than 0.001). Selection against cells containing trisomy 9 is postulated to explain the disappearance of the lymphocyte clone.
Herens
C
C
Human Genetic Department, Liège State University, Belgium.
Pierquin
G
G
Verloes
A
A
Schaaps
J P
JP
Frederic
J
J
D000328:Adult; D000653:Amniotic Fluid / Q000166:cytology*; D002478:Cells, Cultured; D002899:Chromosomes, Human, Pair 9; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D006801:Humans; D007621:Karyotyping; D009030:Mosaicism; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014314:Trisomy