Subcortical cerebral infarctions in sickle cell trait.
At necropsy, two patients with sickle cell trait and progressive motor and visual deficits, lethargy and coma showed infarctions of the deep cerebral white matter and brain stem. The findings in these patients and another reported in the literature suggest that subcortical infarctions may be more common in sickle cell trait than has been recognised and should be suspected in any patient with sickle cell trait who presents with an unusual neurological illness.
Reyes
M G
MG
Division of Pathology (Neuropathology), Hektoen Institute for Medical Research, Cook County Hospital, Chicago, Illinois 60612.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology; D002531:Cerebellum / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D002544:Cerebral Infarction / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology; D005260:Female; D006801:Humans; D009336:Necrosis; D012805:Sickle Cell Trait / Q000473:pathology*