[The kinetics of plasma catecholamine in alkylphosphate poisoning and their therapy].
In connection with the "endogenous acetylcholine-poisoning" due to organophosphorous compounds beside the clinical important muscarinic and nicotinic symptoms an activation of the sympathetic nervous system (adrenal medulla, sympathetic ganglia) is expected. Therefore a kinetic profile of norepinephrine and epinephrine in the plasma of two patients with severe parathion-poisonings was taken up through the whole period of the intensive-medical treatment. The method used was HPLC with electrochemical detection. The parathion-concentration of the same plasma samples were measured, too. The result were individual different courses with periodically appearing, markedly increased plasma catecholamine values. A direct correlation of catecholamines with the parathion-concentration was not recognizable. A possible influence of the atropine-treatment as well as of stress-factors is discussed but estimated as not responsible for the observed peaks.
Kauert
G
G
Institut für Rechtsmedizin der Universität München.
Schoppek
B
B
von Clarmann
M
M
Hibler
A
A
D000328:Adult; D000368:Aged; D002802:Cholinesterases / Q000097:blood; D004837:Epinephrine / Q000097:blood*; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D010278:Parathion / Q000493:pharmacokinetics / Q000506:poisoning*; D012151:Resuscitation; D013406:Suicide, Attempted
D010278:Parathion; D002802:Cholinesterases; D009638:Norepinephrine; D004837:Epinephrine
Plasma-Katecholamin-Verlauf bei Alkylphosphat-Intoxikationen und deren Therapie.