[Primary structure of the avian influenza virus A/FVP/Weybridge hemagglutinin gene].
The complete primary structure of cDNA for hemagglutinin gene of influenza virus A/FPV/weybridge/27 subtype H7 has been determined. Its comparison with the structures of analogous genes from other strains of the same subtype has shown 75% of base changes resulting in silent mutations. This suggests the weak immunological pressing in course of evolution of this subtype strains. The reason for apathogenicity of this avian strain is supposed to be elimination of a glycosylation site present in the strain A/FPV/Rostock/34. The possibility of using the obtained data for construction of the new generation of vaccines is discussed.
Netesov
S V
SV
Golovin
S Ia
SIa
Frolov
I V
IV
Mikriukova
T P
TP
Safronov
P F
PF
D000595:Amino Acid Sequence; D001483:Base Sequence; D005814:Genes, Viral; D006389:Hemagglutinins, Viral / Q000235:genetics*; D009980:Influenza A virus / Q000235:genetics*; D008969:Molecular Sequence Data
D006389:Hemagglutinins, Viral
Pervichnaia struktura gena gemaggliutinina virusa grippa ptits A/FPV/Weybridge.