[Pseudohypertrophic proximal progressive muscular dystrophy with a malignant course manifesting itself in adolescence].
The authors describe an unique case of progressive muscular dystrophy in four brothers T. The disease was peculiar in its debut in adolescence, localization of muscular atrophies in proximal limbs, pseudohypertrophy of various muscular groups, malignant course of the myodystrophy with concomitant endocrine and metabolic disorders. A primarily muscular nature of the disease was confirmed in electrophysiological and pathological investigation. X-linked recessive inheritance of the progressive muscular dystrophy was supposed in T family. The issues of differential diagnosis, clinical polymorphism and genetical heterogeneity of X-linked recessive progressive muscular dystrophies are discussed.
Badalian
L O
LO
Temin
P A
PA
Saidbegov
D G
DG
Nikitin
M V
MV
Arkhipov
B A
BA
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D006801:Humans; D006984:Hypertrophy; D008297:Male; D009132:Muscles / Q000473:pathology*; D009136:Muscular Dystrophies / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D010375:Pedigree; D014960:X Chromosome
Psevdogipertroficheskaia proksimal'naia progressiruiushchaia myshechnaia distrofiia s debiutom v podrostkovom vozraste i zlokachestvennym techeniem.