Low frequency stimulation induces an increase in after-discharge thresholds in hippocampal and amygdaloid kindling.
In rats with electrodes implanted in the hippocampus or amygdala, the effect was studied of a single episode of low frequency stimulation (125 msec, biphasic 4 Hz, for 1 min at a current 50% of threshold for after-discharge), LFS, on the after-discharge thresholds (ADTs) during the course of hippocampal and amygdaloid kindling. ADTs were significantly increased following the LFS. The effect lasted longer (hippocampus, 12 days; amygdala, 5 days) when the LFS was given on day 1 of kindling than when kindling was fully established (less than 24 h).
Ullal
G R
GR
Department of Neurosurgery, Hamamatsu University School of Medicine, Shizuoka, Japan.
Ninchoji
T
T
Uemura
K
K
D000200:Action Potentials; D000679:Amygdala / Q000503:physiopathology*; D000818:Animals; D004558:Electric Stimulation; D004827:Epilepsy / Q000503:physiopathology; D006624:Hippocampus / Q000503:physiopathology*; D007696:Kindling, Neurologic; D051381:Rats; D011919:Rats, Inbred Strains