Metabolism of octanoyl- and palmitoylcarnitine by intact rat hepatocytes.
Ketogenesis from extracellular substrates was quantified using intact rat hepatocytes. Rates of ketogenesis from octanoylcarnitine and palmitoylcarnitine were 20 and 30%, respectively, of the rates observed from the corresponding free acids. In contrast, the free acids and the acylcarnitines were converted to ketone bodies at similar rates in a liver homogenate system. These results suggest that medium- and long-chain acylcarnitines may be relatively poor substrates for metabolism by intact liver cells.
Brass
E P
EP
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262.
D000818:Animals; D002331:Carnitine / Q000031:analogs & derivatives* / Q000378:metabolism; D066298:In Vitro Techniques; D007657:Ketone Bodies / Q000096:biosynthesis; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D010172:Palmitoylcarnitine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D007657:Ketone Bodies; D010172:Palmitoylcarnitine; C008698:octanoylcarnitine; D002331:Carnitine