title: Effects of nicotine gum and tobacco smoking on human avoidance responding.
abstract: Three male smokers were exposed to a free-operant avoidance schedule in which a lever press postponed a point subtraction on a counter for twenty seconds. Subtractions were scheduled to occur every 5 seconds in the absence of lever presses. Prior to each experimental session the subject was administered varying amounts of nicotine via either chewing nicotine gum or smoking low or high nicotine yield cigarettes. Smoking cigarettes resulted in increased avoidance responding relative to baseline nonsmoking rates. Chewing nicotine gum did not produce changes in avoidance responding, however, nicotine blood levels produced by chewing nicotine gum were similar to levels produced by smoking cigarettes. The differential responding determined by route of nicotine administration is discussed and the implications for use of nicotine gum as an adjunct for smoking cessation is addressed.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Texas Medical School, Houston.
authors.forename: D R
authors.initials: DR
authors.lastname: Cherek
authors.forename: R H
authors.initials: RH
authors.lastname: Bennett
authors.forename: T H
authors.initials: TH
authors.lastname: Kelly
authors.forename: J L
authors.initials: JL
authors.lastname: Steinberg
authors.forename: N L
authors.initials: NL
authors.lastname: Benowitz
mesh_terms: D001362:Avoidance Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage*; D012907:Smoking / Q000503:physiopathology*
chemical_list: D009538:Nicotine