Exacerbation of human cataplexy by prazosin.
A middle-aged woman with narcolepsy developed a pronounced exacerbation of cataplexy within 3 days of beginning treatment for hypertension with prazosin, an alpha 1-adrenoceptor antagonist. At times, episodes of cataplexy were virtually continuous (status cataplecticus), and there was only partial amelioration with tricyclic antidepressants. Cataplexy improved when prazosin was discontinued. These findings are similar to the reported effects of prazosin on cataplexy in narcoleptic dogs; they support a role for altered alpha 1-adrenoceptor function in narcolepsy.
Aldrich
M S
MS
Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109/0316.
Rogers
A E
AE
D002385:Cataplexy / Q000139:chemically induced*; D005260:Female; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D011224:Prazosin / Q000009:adverse effects* / Q000627:therapeutic use; D012894:Sleep Stages / Q000187:drug effects
D011224:Prazosin