title: Alcohol-induced coagulation necrosis in cardiac tissue: a new concept in the surgical management of recurrent ventricular arrhythmias.
abstract: Post myocardial infarction recurrent ventricular arrhythmias are usually coupled with depressed left ventricular function. We have until recently employed the most widely used surgical techniques such as endocardial resection, cryosurgery and isolation. After these methods had failed in a patient with an extensive septal focus, it finally became possible to effectively ablate the arrhythmogenic area by injection of 10 ml 95% alcohol subendocardially. The following experimental studies were carried out to investigate the effect of direct injection of alcohol on the myocardicytes. 95% alcohol, injected into the apex of the left ventricle of Wistar rats weighing between 150 and 200 g caused extensive coagulation necrosis 5 minutes after injection, as was revealed by histological examination. The site of injection showed marked scar formation after 6 months. On the basis of these findings, 4 more patients were treated successfully with alcohol, which was directly injected subendocardially without endocardial resection using a long needle. The advantage of this procedure is that resection can be avoided, particularly in critical areas such as the septum and regions around papillary muscles.
authors.affiliation: Department of Cardiovascular Surgery and Experimental Cardiology, University Hospital, Hamburg, FRG.
authors.forename: K
authors.initials: K
authors.lastname: Ayisi
authors.forename: J
authors.initials: J
authors.lastname: Darup
authors.forename: H J
authors.initials: HJ
authors.lastname: Krebber
authors.forename: G
authors.initials: G
authors.lastname: Rodewald
authors.forename: K H
authors.initials: KH
authors.lastname: Kuck
mesh_terms: D000818:Animals; D003327:Coronary Disease / Q000150:complications; D004562:Electrocardiography; D000431:Ethanol / Q000008:administration & dosage*; D006329:Heart Conduction System / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D007267:Injections; D009336:Necrosis; D051381:Rats; D012008:Recurrence; D013610:Tachycardia / Q000188:drug therapy*; D014693:Ventricular Fibrillation / Q000188:drug therapy*
chemical_list: D000431:Ethanol