title: Chromosomal rearrangement on chromosome 11q14-q21 in T cell acute lymphoblastic leukemia.
abstract: Deletion and translocation involving the bands 11q14 and 11q21 have been detected in five patients with T cell acute lymphoblastic leukemia (ALL). The breakpoint on chromosome 11 was on the same band as that previously described in some acute nonlymphocytic leukemias: monocytic or myelomocytic. The existence of a new nonrandom rearrangement involving bands 11q14-q21 is postulated in ALL. An unusual rearrangement on 11q13 in a patient with T cell ALL is also reported.
authors.affiliation: Unité INSERM U. 301, CNRS, Hopital Saint Louis, Paris.
authors.forename: R
authors.initials: R
authors.lastname: Berger
authors.forename: M
authors.initials: M
authors.lastname: Le Coniat
authors.forename: J
authors.initials: J
authors.lastname: Derré
authors.forename: D
authors.initials: D
authors.lastname: Vecchione
authors.forename: S J
authors.initials: SJ
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic