title: Micronucleus test with colchicine given by intraperitoneal injection and oral gavage.
abstract: The effects of micronucleus induction in mouse bone marrow cells by intraperitoneal injection (i.p.) and oral administration (p.o.) were studied with the spindle poison colchicine in 2 strains of mice (MS/Ae and CD-1). The final micronucleus test was performed with a 24-h sampling time at doses of 0.25-2.0 mg/kg by the i.p. route and 2-16 mg/kg by the p.o. route based on a simple acute toxicity test and a pilot micronucleus experiment. Colchicine induced micronuclei in both strains and at all doses tested. Micronuclei were induced more effectively by the i.p. route.
authors.affiliation: Biochemical Research Laboratory, Nitto Denko Corporation, Osaka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Asano
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003078:Colchicine / Q000008:administration & dosage* / Q000633:toxicity; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000008:administration & dosage*; D010865:Pilot Projects
chemical_list: D009153:Mutagens; D003078:Colchicine