title: Effects of the acute subcutaneous administration of synthetic salmon calcitonin in tumoral calcinosis.
abstract: We examined the effects of the acute administration of salmon calcitonin on phosphate metabolism in tumoral calcinosis. On two different days, 200 MRC U of the synthetic hormone were administered sc to a 38-year-old patient, either as twice daily 100 MRC U injections, or as a continuous sc infusion via a portable pump. Both ways of calcitonin administration elicited a phosphaturic effect and a lowering of serum phosphate level comparable with that observed after an iv infusion of calcitonin. 1,25 dihydroxyvitamin D level, which was in the normal range during a control study, increased after calcitonin administration. In our patient, long term therapy with diet, a phosphate-binding agent and calcitonin prevented the occurrence of new ectopic calcifications. Owing to its phosphaturic activity, synthetic salmon calcitonin may be a useful adjunct to diet and aluminium-containing antacids in long-term management of tumoral calcinosis.
authors.affiliation: Istituto di Patologia Medica, University of Brescia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Candrina
authors.forename: B
authors.initials: B
authors.lastname: Cerudelli
authors.forename: V
authors.initials: V
authors.lastname: Braga
authors.forename: A
authors.initials: A
authors.lastname: Salvi
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000178:diet therapy / Q000188:drug therapy* / Q000378:metabolism; D002116:Calcitonin / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006728:Hormones / Q000008:administration & dosage*; D006801:Humans; D007279:Injections, Subcutaneous; D010710:Phosphates / Q000378:metabolism
chemical_list: D006728:Hormones; D010710:Phosphates; C028815:salmon calcitonin; D002116:Calcitonin