title: Surface tension and pulmonary compliance in premature rabbits.
abstract: In vitro surface properties of pulmonary surfactant thought to be essential to its ability to increase pulmonary compliance include minimum surface tension less than 10 dyn/cm and large surface tension variability and hysteresis. We tested four surface-active agents (Tween 20, a detergent; and FC-100, FC-430, and FC-431, industrial fluorocarbons), all lacking these properties, for their ability to increase pulmonary compliance in surfactant-deficient premature rabbits. Fetal rabbits were delivered by cesarean section at 27 days (full term = 31 days) and injected via tracheostomy with 50% lactated Ringer solution, adult rabbit surfactant, or one of the four experimental agents. Dynamic compliance was measured using 1 h of mechanical ventilation followed by alveolar lavage. Each experimental agent produced a dynamic compliance significantly higher than 50% lactated Ringer solution and statistically equal to or greater than natural surfactant. Equilibrium surface tension of the agents and minimum and equilibrium surface tension of the alveolar washes each correlated with compliance (P less than 0.05). This suggests that some surface properties of pulmonary surfactant believed to be essential are not, although surface tension does seem to play a role in pulmonary compliance.
authors.affiliation: Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510.
authors.forename: M R
authors.initials: MR
authors.lastname: Mercurio
authors.forename: J M
authors.initials: JM
authors.lastname: Fiascone
authors.forename: D M
authors.initials: DM
authors.lastname: Lima
authors.forename: H C
authors.initials: HC
authors.lastname: Jacobs
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002585:Cesarean Section; D005260:Female; D008168:Lung / Q000196:embryology / Q000502:physiology*; D008170:Lung Compliance; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000502:physiology*; D011817:Rabbits; D012121:Respiration, Artificial; D013500:Surface Tension
chemical_list: D011663:Pulmonary Surfactants