title: Thrombolytic activity of defibrotide: a morphometric evaluation in experimental venous thrombosis.
abstract: We have studied the morphometric aspects of the thrombolytic activity of Defibrotide in experimental venous thrombosis induced by inserting a collagen-coated nylon thread into the femoral vein of rabbits. 24 hours after thrombus induction Defibrotide decreases the size of thrombi by a factor of 6; stimulation of fibrinolysis and inhibition of platelet and leucocyte recruitment are prominent. Size of the thrombus, extension of the fibrin net and platelet adhesion are also modified by Defibrotide in 7-day-old thrombi where granulation tissue has replaced the original coagulum.
authors.affiliation: Department of Pharmacology, School of Medicine, University of Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Fumagalli
authors.forename: C
authors.initials: C
authors.lastname: Sala
authors.forename: E
authors.initials: E
authors.lastname: Angelaccio
authors.forename: N
authors.initials: N
authors.lastname: Lombardo
authors.forename: F
authors.initials: F
authors.lastname: Clementi
mesh_terms: D000818:Animals; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D007958:Leukocyte Count; D011089:Polydeoxyribonucleotides / Q000494:pharmacology*; D011817:Rabbits; D013924:Thrombophlebitis / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D005343:Fibrinolytic Agents; D011089:Polydeoxyribonucleotides; C036901:defibrotide