Acute and chronic effects of a nutmeg extract on the toad heart.
Electrocardiographic and flexible suction electrode techniques were used to investigate the effects of a nutmeg extract on the toad heart. Acute treatment with the extract resulted in a dose-related sinus tachycardia, faster atrioventricular conduction speed and an increased amplitude of ventricular action potential. Chronic treatment resulted in sinus bradycardia and decreased amplitude and increased duration of ventricular action potential.
Saleh
M
M
Department of Zoology, Faculty of Science, Al Azhar University, Nasr City, Cairo, Egypt.
Nabil
Z
Z
Mekkawy
H
H
Abd Allah
G
G
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002025:Bufonidae; D003212:Condiments / Q000009:adverse effects*; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D013997:Time Factors