Effect of 17-beta-estradiol on doxorubicin cytotoxicity in human breast cancer cell culture.
Pre-treatment with 17-beta-estradiol appeared to improve the cytotoxic efficacy of doxorubicin on MCF-7 but not on ZR-75-1 and EVSA-T human breast cancer cell lines. MCF-7 and ZR-75-1 are both estrogen receptor-positive cell lines: however, only ZR-75-1 showed improved proliferation in the presence of estradiol. On the other hand MCF-7 appeared basically more resistant to doxorubicin compared to the other cell lines. The results indicate that estrogenic pre-treatment is a potential tool for partially overcoming human breast cell resistance to doxorubicin; moreover, they suggest that the mechanism of interaction could be not exclusively related to actual cytokinetics modulation.
Toma
S
S
Istituto di Oncologia, Universita di Genova, Italy.
Leonessa
F
F
Coialbu
T
T
Nicolo
G
G
Rosso
R
R
D001943:Breast Neoplasms / Q000188:drug therapy*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000633:toxicity; D004357:Drug Synergism; D004958:Estradiol / Q000008:administration & dosage*; D006801:Humans; D011960:Receptors, Estrogen / Q000032:analysis; D014407:Tumor Cells, Cultured / Q000187:drug effects
D011960:Receptors, Estrogen; D004958:Estradiol; D004317:Doxorubicin