Effect of a new fluorinated quinolone (ofloxacin) on the chemiluminescence of phagocytosing human neutrophils.
We measured the chemiluminescence (CL) of human neutrophils (PMNLs) exposed to different concentrations of ofloxacin (2, 4, and 6 micrograms/ml) readily achievable in therapy. CL reaction during zymosan phagocytosis by PMNLs obtained from human healthy volunteers was registered in a computer-linked LKB 1251 luminometer. Ofloxacin did not induce significant variations on the respiratory burst of PMNLs.
Aquilini
D
D
Chair of Infectious Diseases, University of Florence, Italy.
Bartoloni
A
A
Paradisi
F
F
D006801:Humans; D008163:Luminescent Measurements; D009504:Neutrophils / Q000276:immunology*; D015242:Ofloxacin / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*
D015242:Ofloxacin