title: Influence of pyrazine derivatives on the day of vaginal opening in juvenile female rats.
abstract: Effects of pyrazine derivatives on the day of the first opening of the vagina in juvenile female rats were studied. Tetraethyl and 2,5-dimethyl pyrazine caused a significant delay in the first vaginal opening day of juvenile female rats, but no delay was noted in the case of 2,5-diethyl or triethyl pyrazine. These results suggest that tetraethyl and 2,5-dimethyl pyrazine cause delays in the onset of puberty in juvenile female rats.
authors.affiliation: Laboratory for Pharmaceutical Education, Tokyo College of Pharmacy, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: R
authors.initials: R
authors.lastname: Itoh
authors.forename: A
authors.initials: A
authors.lastname: Ohta
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000187:drug effects; D014621:Vagina / Q000187:drug effects / Q000254:growth & development*
chemical_list: D011719:Pyrazines