title: Oligodeoxynucleotide analogs with 5'-linked anthraquinone.
abstract: We report here the synthesis of novel 5'-linked oligodeoxynucleotides, both normal phosphodiester and phosphorothioate analogs, in which a covalently attached group at the 5'-terminus is an anthraquinone. These compounds represent a new class of antisense compounds in which the base sequence of the oligodeoxynucleotide serves to deliver a nuclease-resistant reactive drug-like molecule to a cellular target nucleic acid (mRNA or DNA).
authors.affiliation: Medicine Branch, National Cancer Institute, NIH, Bethesda, MD 20892.
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: C
authors.initials: C
authors.lastname: Subasinghe
authors.forename: J S
authors.initials: JS
authors.lastname: Cohen
mesh_terms: D000880:Anthraquinones; D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D009838:Oligodeoxyribonucleotides
chemical_list: D000880:Anthraquinones; D009838:Oligodeoxyribonucleotides