[The effect of 2 chloroquine-based drug strategies (prevention and therapy of febrile cases] on malaria transmission].
A 3 years study was decided in 12 villages of the South-West Burkina Faso to compare the chemoprophylaxis and the chemotherapy of febrile cases as potential malaria control strategies. During the first year pretreatment data were collected. During the two following years a programme carried out (I) prophylaxis (10 mg chloroquine/kg body weight) was given weekly to all children under 14 years old in 5 villages, and (II) therapy (10 mg chloroquine/kg body weight) was given in a single dose to all febrile cases in 7 other villages. Chloroquine tablets were distributed by health workers belonging to the community. Both prophylaxis and therapy reduced the gametocyte rate in children (2-9 years) respectively of 63% and 45%. The analysis of the evolution after the first year of the sporozoite rate of anopheline was made difficult by concomitant natural variations of mosquitoes longevity and by mosquitoes displacements. Significant variations of sporozoite rate can be explained by natural variations of mosquitoes longevity. But data from the rice field villages support evidence that reduction of the pool of parasite infective for vectors induced the decrease of Anopheles gambiae s. l. sporozoite rate. Therefore our results reflect a trend more than a strict reduction of malaria transmission.
Robert
V
V
ORSTOM, Paris, France.
Hervy
J P
JP
Baudon
D
D
Roux
J
J
Legros
F
F
Carnevale
P
P
D000293:Adolescent; D000818:Animals; D000852:Anopheles / Q000469:parasitology; D002050:Burkina Faso; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000517:prevention & control; D006801:Humans; D008288:Malaria / Q000517:prevention & control* / Q000635:transmission; D010961:Plasmodium / Q000302:isolation & purification
D002738:Chloroquine
Influence de deux stratégies médicamenteuses par chloroquine (prophylaxie et thérapie des accès fébriles) sur la transmission du paludisme.