title: Widespread quinolone resistance among methicillin-resistant Staphylococcus aureus isolates in a general hospital.
abstract: Ofloxacin and ciprofloxacin resistance (MIC, greater than 4 micrograms/ml) was encountered in 45 of 50 clinical isolates of methicillin-resistant Staphylococcus aureus. None of 20 methicillin-susceptible strains was resistant to the quinolones (P less than 10(-6). Quinolone-susceptible and -resistant isolates did not differ with respect to culture source or bacteriophage type. The future usefulness of quinolones for S. aureus infection may be limited.
authors.affiliation: Department of Infectious Diseases, Tel-Aviv Medical Center, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Shalit
authors.forename: S A
authors.initials: SA
authors.lastname: Berger
authors.forename: A
authors.initials: A
authors.lastname: Gorea
authors.forename: H
authors.initials: H
authors.lastname: Frimerman
mesh_terms: D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006801:Humans; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents; D008712:Methicillin