[Comparative study of 3 successive treatment protocols of osteogenic osteosarcoma in children, adolescents and young adults. Apropos of 100 cases].
Three therapeutic protocols were used successively for the treatment of osteogenic osteosarcoma since 1978. The first protocol associated initial surgery and 12 months of chemotherapy and was applied to 41 patients with good results in adults but poor results in children. A protocol introducing adjuvant chemotherapy based on the association of adriamycin-cisplatinum gave very disappointing results first in children and then in adults. The protocol based on HD MTX gave much more encouraging results: the long version (3 months preoperative chemotherapy) was effective in good responders but did not influence the course of poor responders. The shortened version of this protocol, derived from the T 10 Rosen protocol (1 month preoperative chemotherapy conservative surgery and appropriate peri- and postoperative chemotherapy) seems to transform the prognosis of osteosarcoma. Our current results indicate a complete primary remission rate of 89% at one year, and 83% at 33 months.
Delepine
N
N
Unité d'Oncologie Pédiatrique, Service Pédiatrie, Hôpital Robert-Debré, Paris.
Desbois
J C
JC
Delepine
G
G
Cornille
H
H
Jasmin
C
C
Favre
R
R
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002985:Clinical Protocols; D004334:Drug Administration Schedule; D006801:Humans; D012516:Osteosarcoma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*
Etude comparative de trois protocoles successifs de traitement de l'ostéosarcome ostéogénique de l'enfant, de l'adolescent et de l'adulte jeune. A propos de 100 observations.