title: Synthesis and CVS activity of 1-(2,3, 2,5, 2,6 dichlorophenyl)-3-morpholinophenyl-5-substituted benzylidene-thiobarbituric acids (3-17).
abstract: Fifteen new thiobarbituric acids have been prepared by the Knoevenagel condensation of appropriate aldehydes with 1-(2,3, 2,5, 2,6 dichlorophenyl)-3-morpholinophenyl thiobarbituric acids. Five compounds of this series were found to be biphasic in nature whereas some compounds showed appreciable hypotensive activity of varying magnitude and duration.
authors.affiliation: Department of Chemistry, University of Lucknow, India.
authors.forename: A
authors.initials: A
authors.lastname: Singh
authors.forename: V S
authors.initials: VS
authors.lastname: Misra
mesh_terms: D000818:Animals; D001597:Benzylidene Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D002317:Cardiovascular Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D009025:Morpholines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013858:Thiobarbiturates / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D001597:Benzylidene Compounds; D002317:Cardiovascular Agents; D009025:Morpholines; D013858:Thiobarbiturates