title: Pharmacokinetics of amoxycillin/clavulanic acid in serum and ascitic fluid in cirrhotic patients.
abstract: A combination of amoxycillin and clavulanic acid (Augmentin) might be useful for first-line treatment of spontaneous bacterial peritonitis in patients with cirrhosis. We have studied the pharmacokinetics of amoxycillin/clavulanic acid in serum and ascitic fluid of six cirrhotic patients. A total of 66 simultaneous serum and ascitic samples were analysed. Following iv injection of 1 g amoxycillin plus 0.2 g clavulanic acid, the ascites to serum AUC ratio was 1.38 for amoxycillin and 1.01 for clavulanic acid, indicating a good distribution of these drugs into the ascitic fluid. In this study, experimental data were fitted to a three compartment body model which revealed that the prolonged serum half-lives of amoxycillin (274 min) and clavulanic acid (200 min) were probably due to the slow return from the ascitic compartment.
authors.affiliation: Service d'hépatologie et unité de Pharmacologie Clinique, Hôpital Tenon, Paris, France.
authors.forename: J D
authors.initials: JD
authors.lastname: Grange
authors.forename: A
authors.initials: A
authors.lastname: Gouyette
authors.forename: L
authors.initials: L
authors.lastname: Gutmann
authors.forename: X
authors.initials: X
authors.lastname: Amiot
authors.forename: M D
authors.initials: MD
authors.lastname: Kitzis
authors.forename: S
authors.initials: S
authors.lastname: Islam
authors.forename: J F
authors.initials: JF
authors.lastname: Acar
authors.forename: P
authors.initials: P
authors.lastname: Jaillon
mesh_terms: D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000097:blood / Q000493:pharmacokinetics*; D001202:Ascitic Fluid / Q000378:metabolism*; D001681:Biological Assay; D002969:Clavulanic Acids / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological
chemical_list: D002969:Clavulanic Acids; D000658:Amoxicillin