Sclerosing cholangitis with hepatic microvesicular steatosis in cystic fibrosis and chronic pancreatitis.
The association between asymptomatic primary sclerosing cholangitis and exocrine pancreatic disease was underlined by the findings in a patient with cystic fibrosis and in another with chronic pancreatitis. In each case hepatocytes showed extensive microvesicular steatosis and studies of drug metabolism suggested hepatic enzyme induction: biliary or serum analysis, or both, disclosed raised concentrations of a lipid-based marker of free radical oxidation. These findings suggest that toxic metabolites of oxygen or other chemicals may have a role in the pathogenesis of the bile duct lesion.
Benett
I
I
University Department of Gastroenterology, Royal Infirmary, Manchester.
Salh
B
B
Haboubi
N Y
NY
Braganza
J M
JM
D000328:Adult; D015209:Cholangitis, Sclerosing / Q000150:complications / Q000473:pathology*; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000150:complications / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D010195:Pancreatitis / Q000150:complications / Q000473:pathology*