title: Cell cycle-specific variation of intracellular plasminogen activator activity in cultured human alveolar epithelial carcinoma and rat hepatoma cells.
abstract: Plasminogen activator activity was demonstrated in two carcinoma cell lines: A549 cells derived from a human alveolar epithelial carcinoma; and ZHC cells derived from a rat hepatoma. Both cells had intracellular plasminogen activator activity throughout their cell cycles and in each case this activity reached a maximum. For A549 cells the maximal activity took place either during the G2 phase or in the course of the S to G2 transition, suggesting that plasminogen activator might play a role in cell division. For ZHC cells, the maximal activity occurred at the start of the S phase, suggesting that in these cells plasminogen activator might be involved in DNA replication.
authors.affiliation: Laboratoire de Biologie Cellulaire, Faculté de Pharmacie, Université Louis Pasteur, Illkirch, France.
authors.forename: G
authors.initials: G
authors.lastname: Orfanoudakis
authors.forename: D
authors.initials: D
authors.lastname: Zaoui
authors.forename: J J
authors.initials: JJ
authors.lastname: Befort
authors.forename: J G
authors.initials: JG
authors.lastname: Bieth
mesh_terms: D000818:Animals; D002277:Carcinoma; D006801:Humans; D008114:Liver Neoplasms, Experimental; D008175:Lung Neoplasms; D010960:Plasminogen Activators / Q000378:metabolism*; D051381:Rats; D013936:Thymidine; D014407:Tumor Cells, Cultured / Q000166:cytology* / Q000378:metabolism
chemical_list: D010960:Plasminogen Activators; D013936:Thymidine