High-dose IgG treatment for neonatal alloimmune thrombocytopenia.
Twelve children with neonatal alloimmune thrombocytopenia (NAT) due to Zwa incompatibility were treated with intravenous IgG (IVIG). Total doses ranged between 1 and 9 g. Ten out of 12 infants had a favorable response. It is concluded that IVIG can serve as an emergency treatment in NAT if material (or compatible) platelets are not available.
Mueller-Eckhardt
C
C
Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, Federal Republic of Germany.
Kiefel
V
V
Grubert
A
A
D001792:Blood Platelets / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000008:administration & dosage; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy*; D007519:Isoantigens / Q000276:immunology; D013921:Thrombocytopenia / Q000628:therapy*
D007074:Immunoglobulin G; D007519:Isoantigens