[Activity of lysosomal hydrolases and renewal of proteins in the rat liver, spleen, and thymus during antigenic stimulation and protein deficiency].
Activity of cathepsins B and C was increased 1.8-2-fold in spleen simultaneously with a decrease 3.8-fold in the rate of protein renewal in the tissue lysosomal fraction within 4 days after antigen stimulation of rats, maintained within 45 days on a diet containing 5% of protein. Activation of these thiol-dependent proteinases appears to occur in response to development of immunodepressive conditions and may be related to alterations in the rate of their biosynthesis.
Vasil'ev
A V
AV
Konovalova
L S
LS
Pletsityĭ
K D
KD
Ponomareva
L G
LG
Tutel'ian
V A
VA
D000818:Animals; D000941:Antigens / Q000276:immunology*; D002401:Cathepsin B / Q000378:metabolism; D020789:Cathepsin C; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000378:metabolism; D006207:Half-Life; D006867:Hydrolases / Q000378:metabolism*; D007114:Immunization; D008099:Liver / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D011488:Protein Deficiency / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000378:metabolism; D013347:Subcellular Fractions / Q000032:analysis; D013950:Thymus Gland / Q000378:metabolism
D000941:Antigens; D011506:Proteins; D006867:Hydrolases; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D020789:Cathepsin C; D002401:Cathepsin B
Aktivnost' lizosomal'nykh gidrolaz i obnovlenie belka v pecheni, selezenke i timuse krys pri antigennoĭ stimuliatsii i defitsite belka.