O-demethylation and N4-acetylation of sulfadimethoxine by the snail Cepaea hortensis.
The snail Cepaea hortensis O-dealkylates sulfadimethoxine at the 2- and 6-position, the 2-position being favoured. Sulfadimethoxine is also acetylated, while no measurable acetylation of the hydroxy (= demethyl) metabolites took place.
Vree
T B
TB
Vree
M L
ML
Beneken Kolmer
E W
EW
Hekster
Y A
YA
Shimoda
M
M
Nouws
J F
JF
Yoshioka
T
T
Hoji
K
K
D000107:Acetylation; D000818:Animals; D003640:Dealkylation; D012908:Snails / Q000378:metabolism*; D013412:Sulfadimethoxine / Q000493:pharmacokinetics*
D013412:Sulfadimethoxine