[The disposition of bornaprine hydrochloride in the rat. 1. Pharmacokinetics: synthesis, plasma level and elimination].
The biliary elimination and plasma concentration-time course of radioactivity and unchanged compound of 2-phenyl-bicyclo-[2.2.1]- heptane-2-carboxlylic acid (4'-diethylamino-propyl)ester hydrochloride (bornaprine hydrochloride, Sormodren) were investigated after oral application in Wistar rats. The curves showed no obvious differences in their pharmacokinetic properties.
Neidlein
R
R
Pharmazeutisch-chemisches Institut der Universität Heidelberg.
Pichler
B
B
Hege
G
G
Weymann
J
J
D000818:Animals; D001646:Bile / Q000378:metabolism; D001952:Bridged-Ring Compounds / Q000097:blood / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007553:Isotope Labeling; D008297:Male; D010276:Parasympatholytics / Q000097:blood / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility
D001952:Bridged-Ring Compounds; D010276:Parasympatholytics; C006088:bornaprine
Zur Disposition von Bornaprin-Hydrochlorid bei der Ratte. 1. Mitteilung: Untersuchungen zur Pharmakokinetik: Synthese, Plasmaspiegel und Elimination.