title: Allergenicity of orange juice and orange seeds: a clinical study.
abstract: Oranges are considered to be common allergenic fruits in China. They may induce severe food allergy in sensitive individuals. Allergic histories were analyzed in 26 orange-sensitive patients. Intradermal tests with extracts of orange juice and seeds were performed in 16 out of the 26 patients. P-K test was performed in one patient. The allergic history analysis suggested that clinical symptoms of some orange-allergic subjects were different from other fruit allergies but similar to nut and other oil plant seed allergies. The skin test and P-K test showed that the major allergenic components of orange reside in orange seeds instead of orange juice. Systemic reactions developed in 5 patients after intradermal tests with 1:20-200 (w/v) orange seed extracts. We considered that orange seed contains high potent allergens which may induce orange sensitivity due to careless chewing of orange seeds.
authors.affiliation: Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing.
authors.forename: S L
authors.initials: SL
authors.lastname: Zhu
authors.forename: S T
authors.initials: ST
authors.lastname: Ye
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
mesh_terms: D000328:Adult; D000485:Allergens / Q000592:standards; D001628:Beverages / Q000009:adverse effects*; D002681:China; D002957:Citrus / Q000009:adverse effects*; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D012639:Seeds / Q000276:immunology*; D012882:Skin Tests / Q000379:methods
chemical_list: D000485:Allergens