title: Mitoxantrone as single agent in the treatment of advanced breast cancer: clinical experience at Siriraj Hospital.
abstract: A total of 35 patients with advanced breast cancer were treated with mitoxantrone, 14 mg/m2 I.V. every 3 weeks. Of these, 27 patients or 78 lesions could be evaluated for response and all 35 patients for toxicity. The overall response rate (CR + PR) was 35 per cent (or CR + PR + SD = 82%), ten lesions achieved a complete response and 17 lesions a partial response. The duration of response varied from a minimum of 2 months to more than 11 months (median = 4 months). Myelosuppression was the dose-limiting toxicity with moderate to severe degree in 19 patients. The most frequent severe degree in 19 patients. The most frequent non-hematologic toxicity was mild grade of nausea and vomiting (67%). No cardiotoxicity was noted in this study after the maximum cumulative dose of mitoxantrone 157.5 mg.
authors.forename: P
authors.initials: P
authors.lastname: Tepmongkol
authors.forename: N
authors.initials: N
authors.lastname: Suphaphongs
authors.forename: A
authors.initials: A
authors.lastname: Thansakul
authors.forename: S
authors.initials: S
authors.lastname: Jirapanuwat
authors.forename: V
authors.initials: V
authors.lastname: Skulchan
authors.forename: S
authors.initials: S
authors.lastname: Rojananin
authors.forename: N
authors.initials: N
authors.lastname: Chantarakul
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D008942:Mitoxantrone / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D008942:Mitoxantrone