Constitutional C-band polymorphism in lymphocytes from patients with chronic myeloid leukemia.
The C-band heterochromatin polymorphism of chromosomes 1, 9, and 16 was studied in lymphocytes from 53 patients with Ph1-positive chronic myeloid leukemia (CML) and 183 control persons. The patients had significantly larger heterochromatic blocks on chromosome 16 (p less than 0.01) and fewer partial inversions of chromosome 9 (p less than 0.05) than the control persons, whereas no differences were found for the symmetry/asymmetry pattern. We suggest that the increased constitutive heterochromatin regions may, via sister chromosome exchange, facilitate homo- or hemizygotization of genes which favor neoplasia development and/or progression.
Kristoffersson
U
U
Bernheim
A
A
Berger
R
R
Nilsson
B
B
Heim
S
S
Mandahl
N
N
Mitelman
F
F
D002869:Chromosome Aberrations; D002871:Chromosome Banding; D007446:Chromosome Inversion; D002878:Chromosomes, Human, Pair 1 / Q000648:ultrastructure; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure; D002899:Chromosomes, Human, Pair 9 / Q000648:ultrastructure; D006570:Heterochromatin / Q000648:ultrastructure*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D011110:Polymorphism, Genetic; D012854:Sister Chromatid Exchange
D006570:Heterochromatin