title: [Proteus syndrome. A contribution to the further differential diagnosis of congenital local gigantism].
abstract: Four sporadically occurring characteristic cases of the Proteus syndrome are described. All patients show the main features of the disease, consisting of hemihypertrophy, partial gigantism of hands and/or feet with soft-tissue hypertrophy, plane naevi, subcutaneous tumours, and cranial anomalies. There is a remarkable polymorphism of the symptoms. Anamnestic, clinical and paraclinical findings are shown in tables. Based on a survey of the literature, the main aspects of genetics and of differential diagnosis are discussed.
authors.affiliation: Klinik für Kinderheilkunde der Medizinischen Akademie Magdeburg, DDR.
authors.forename: B O
authors.initials: BO
authors.lastname: Trappe
authors.forename: E
authors.initials: E
authors.lastname: Rupprecht
authors.forename: E
authors.initials: E
authors.lastname: Bosselmann
authors.forename: M
authors.initials: M
authors.lastname: Schaeper
authors.forename: K
authors.initials: K
authors.lastname: Mohnike
authors.forename: J
authors.initials: J
authors.lastname: Gedschold
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005532:Foot Deformities, Congenital / Q000235:genetics*; D005877:Gigantism / Q000235:genetics*; D006228:Hand Deformities, Congenital / Q000235:genetics*; D006801:Humans; D008297:Male; D013577:Syndrome
vernacular_title: Das Proteus-Syndrom. Ein Beitrag zur weiteren Differentialdiagnose des angeborenen örtlichen Riesenwuchses.