title: [Clinical usefulness of the blood gastrin curve after protein meal in duodenal ulcer].
abstract: Conflicting data are present in the literature on pathophysiological role of serum gastrin and peptic ulcer disease. The aim of this study was to evaluate, in duodenal ulcer patients, the possible correlation between post-prandial serum gastrin concentrations and some epidemiological (sex, family history, onset of the disease, blood group status, smoking habit, alcohol consumption) and clinical (effectiveness of therapy, bleeding episodes) factors. The gastrin levels were expressed in absolute values and as per cent increase of fasting serum gastrin concentrations. As regards sex, the per cent increase of fasting serum gastrin concentration was significantly higher in females (No. 16) than in males (No. 60) at 30 and 60 minutes (192.25% vs 116.52% and 105.42% vs 40.96% respectively; p less than 0.05 and p less than 0.005). Post-prandial serum gastrin concentrations, expressed as per cent increase, were higher in heavy drinkers (No. 14) and statistically significant at 120 minutes (40.57% vs 9.58%, p less than 0.025); as well as in smoker patients (No. 31), at 15, 30 and 60 minutes (227.59% vs 123.52%, 177.23% vs 101.62%, 0.025 and p less than 0.05). Post-prandial gastrin was unrelated to blood group status, onset of the disease, family history, effectiveness of medical treatment and bleeding episodes.
authors.affiliation: Policlinico Universitario, Padova.
authors.forename: L
authors.initials: L
authors.lastname: Gottardello
authors.forename: E
authors.initials: E
authors.lastname: Galeazzi
authors.forename: R
authors.initials: R
authors.lastname: Pagano
authors.forename: R
authors.initials: R
authors.lastname: Cannizzaro
authors.forename: C
authors.initials: C
authors.lastname: Pasquali
authors.forename: G
authors.initials: G
authors.lastname: Battaglia
authors.forename: F
authors.initials: F
authors.lastname: Vianello
authors.forename: F
authors.initials: F
authors.lastname: Di Mario
authors.forename: R
authors.initials: R
authors.lastname: Naccarato
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D004044:Dietary Proteins / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D004435:Eating; D005215:Fasting; D005260:Female; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000097:blood / Q000209:etiology; D012737:Sex Factors; D012907:Smoking; D013997:Time Factors
chemical_list: D004044:Dietary Proteins; D005755:Gastrins
vernacular_title: Utilità clinica della curva gastrinemica dopo pasto proteico nella malattia ulcerosa duodenale.