[Significance of morphologic signs of primary tumor for the prognosis of metastases of renal cell carcinoma].
The purpose of the study was to determine the value of macro- and microscopic signs of primary tumor that had the highest chance to contribute to metastatic growth in renal cancer patients within 3 years after nephrectomy. The study covered 92 cases of renal cancer, including 42 cases with, and 50 cases, without metastases by the time of surgery, autopsy or within 3 years after nephrectomy. Diagnostic coefficients were calculated for each sign by means of the consecutive Walde's analysis, and their respective values were estimated by Coulbaque's formula. The degree of malignancy was assessed on the basis of a combination of quantitative parameters of proliferative activity and cataplasia of the tumor. The degree of malignancy, tumor stage by the PTNM classification, size and growth pattern, renal vein involvement and the volume of necrotic foci were the most valuable predictors of metastatic growth.
Vlodavskii
E A
EA
D002292:Carcinoma, Renal Cell / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007680:Kidney Neoplasms / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis
Znachenie morfologicheskikh priznakov pervichnoi opukholi dlia prognozirovaniia metastazov pochechnokletochnogo raka.