[Influence of ascites on splanchnic and systemic hemodynamics in patients with alcoholic cirrhosis].
The effect of ascites on splanchnic and systemic hemodynamics was retrospectively studied in 256 patients with alcoholic cirrhosis. The patients were divided into 3 classes: no ascites, moderate ascites, and large ascites. They were also classed into 3 groups according to a modified Pugh classification (ascites was not taken into account). In patients without ascites, cardiac output was positively related to the severity of liver disease. This result was not found in patients with large ascites. Similarly, in patients with no or moderate ascites, the degree of portal hypertension estimated by the hepatic venous pressure gradient was associated with liver failure. In patients with large ascites, hepatic venous pressure gradient was higher than in patients without ascites but this relation was observed only in patients without liver failure. These results show that ascites reduces the relation between cardiac output and liver failure and increases the degree of portal hypertension but not cardiac output.
Cereda
J M
JM
Unité de Recherches de Physiopathologie Hépatique, INSERM U 24, Hôpital Beaujon, Clichy.
Braillon
A
A
Ozier
Y
Y
Moreau
R
R
Gaudin
C
C
Lebrec
D
D
D001201:Ascites / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000503:physiopathology*; D012189:Retrospective Studies; D013152:Splanchnic Circulation
Influence de l'ascite sur l'hémodynamique splanchnique et systémique chez les malades atteints de cirrhose alcoolique.