Transient blueberry muffin appearance of a newborn with congenital monoblastic leukemia.
A full-term male infant was born with skin findings suggesting a blueberry muffin appearance. Biopsy of a cutaneous nodule was consistent with monoblastic leukemia cutis, and bone marrow examination confirmed the diagnosis of leukemia. The infant has remained well 2 years after spontaneous resolution of the cutaneous eruption. Infiltrative neoplasms should be considered along with congenital infections and hematologic disorders in the differential diagnosis of a newborn with a blueberry muffin appearance.
Gottesfeld
E
E
Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH.
Silverman
R A
RA
Coccia
P F
PF
Jacobs
G
G
Zaim
M T
MT
D001706:Biopsy; D003937:Diagnosis, Differential; D004920:Erythropoiesis; D006801:Humans; D007231:Infant, Newborn; D007948:Leukemia, Monocytic, Acute / Q000151:congenital / Q000473:pathology*; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008297:Male; D009365:Neoplasm Regression, Spontaneous; D010859:Pigmentation Disorders / Q000151:congenital / Q000473:pathology*; D012878:Skin Neoplasms / Q000151:congenital / Q000473:pathology*