title: Attenuation of nucleus basalis of Meynert lesion-induced cholinergic deficits by nerve growth factor.
abstract: Nerve growth factor (NGF) was administered into either the lateral ventricle or into the basal forebrain of n. basalis of Meynert (nbM) lesioned rats. Rats received either continuous infusion of 5 micrograms of 7S NGF per day for 28 days, or 5 micrograms of 7S NGF on 4 occasions distributed evenly during the first two post-lesion weeks. The administration of NGF reduced lesion-induced cortical cholinergic marker deficits by approximately 50%, irrespective of the locus or mode of NGF administration. Thus NGF is able to attenuate lesion-induced cholinergic deficits across a range of treatment and lesion conditions.
authors.affiliation: Mount Sinai School of Medicine, Veterans Administration Medical Center, NY.
authors.forename: V
authors.initials: V
authors.lastname: Haroutunian
authors.forename: P D
authors.initials: PD
authors.lastname: Kanof
authors.forename: K L
authors.initials: KL
authors.lastname: Davis
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects / Q000502:physiology*; D002799:Cholinergic Fibers / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009416:Nerve Regeneration / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D009414:Nerve Growth Factors