title: Mouse serum contains two erythroid progenitor-stimulating activities, one being highly increased in serum from anemic mice.
abstract: We previously observed that the addition of normal mouse serum to mouse bone marrow cell cultures increases the number of erythroid colonies arising from erythroid colony-forming units (CFU-E). In this paper, we show that the stimulating activity could be divided into two active fractions with 110 kd and 50 kd apparent molecular weight by gel filtration. The 50-kd fraction, in addition to its stimulating activity, increased the sensitivity of CFU-E to erythropoietin. The 110-kd activity was hardly detectable in normal mouse serum but was greatly increased in anemic mouse serum. This renders this activity of interest and suggests that it may play a regulatory role in mouse erythropoiesis.
authors.affiliation: Laboratory of Cell Biology, Claude Bernard University, Villeurbanne, France.
authors.forename: S
authors.initials: S
authors.lastname: Arnaud
authors.forename: G
authors.initials: G
authors.lastname: Mouchiroud
authors.forename: M
authors.initials: M
authors.lastname: Arnaud
authors.forename: A
authors.initials: A
authors.lastname: Niveleau
authors.forename: J P
authors.initials: JP
authors.lastname: Blanchet
mesh_terms: D000740:Anemia / Q000097:blood*; D000818:Animals; D001798:Blood Proteins / Q000032:analysis / Q000494:pharmacology / Q000502:physiology*; D002850:Chromatography, Gel; D004357:Drug Synergism; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000494:pharmacology; D051379:Mice; D008970:Molecular Weight
chemical_list: D001798:Blood Proteins; D004921:Erythropoietin