The pharmacokinetics of tertiary butanol in C57BL/6J mice.
Doses of 5.0, 10.0, and 20.0 mmoles/kg of t-butanol were given to C57BL/6J mice in order to study the in vivo pharmacokinetics of the alcohol in this strain. A pseudozero order decline in blood concentrations which was directly proportional to dose suggested Michaelis-Menten kinetics. PCNONLIN analysis of the data, however, yielded Vmax estimates which increased with dose and VD estimates which decreased with dose. These results are inconsistent with the Michaelis-Menten model and suggest either multiple elimination pathways or dose related effects on distribution or elimination.
Faulkner
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College of Pharmacy, Ohio Northern University, Ada 45810.
Hussain
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D000818:Animals; D000440:Butanols / Q000493:pharmacokinetics*; D002849:Chromatography, Gas; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012890:Sleep / Q000187:drug effects; D013997:Time Factors; D020002:tert-Butyl Alcohol
D000440:Butanols; D020002:tert-Butyl Alcohol