title: Effects of tamoxifen on spinal bone density in women with breast cancer.
abstract: Bone densitometry (L2-L4) was performed on 10 postmenopausal women with breast cancer after 0, 6, and 12 months of tamoxifen treatment; the results were compared with data from 10 normal controls. The patients and controls differed significantly at 6 (P less than .05) and 12 (P less than .003) months. The tamoxifen group showed a nonsignificant mean gain in bone mineral density after 6 and 12 months of treatment (+0.024 +/- 0.014 and +0.022 +/- 0.018 g/cm2, respectively), whereas the controls showed a nonsignificant mean loss of bone mass at 6 months (-0.012 +/- 0.018 g/cm2) and a statistically significant loss of bone density after 12 months (-0.024 +/- 0.01 g/cm2). These preliminary data suggest that tamoxifen use is associated with preservation of bone mass during the first year of treatment.
authors.affiliation: Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY.
authors.forename: S
authors.initials: S
authors.lastname: Turken
authors.forename: E
authors.initials: E
authors.lastname: Siris
authors.forename: D
authors.initials: D
authors.lastname: Seldin
authors.forename: E
authors.initials: E
authors.lastname: Flaster
authors.forename: G
authors.initials: G
authors.lastname: Hyman
authors.forename: R
authors.initials: R
authors.lastname: Lindsay
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D003720:Densitometry; D005260:Female; D006801:Humans; D008875:Middle Aged; D008903:Minerals / Q000032:analysis; D010024:Osteoporosis / Q000517:prevention & control; D013131:Spine / Q000187:drug effects* / Q000378:metabolism; D013629:Tamoxifen / Q000627:therapeutic use*
chemical_list: D008903:Minerals; D013629:Tamoxifen