Factors affecting serum sialic acid levels.
Inoculation of certain immunostimulators (BCG, Freund's adjuvant) as well as several antigens or Silasorb resulted in a 2- to 3-fold increase of the serum sialic acid level in mice. In contrast, treatments causing immunosuppression, like gamma-radiation and application of cyclophosphamide, did not influence the serum sialic acid level. Furthermore, immunosuppression did not prevent the increase caused by immunostimulators. The results suggest that macrophages may be involved in regulating the serum sialic acid levels after immunostimulation.
Gydow
G
G
Central Institute for Cancer Research, Department of Virology, Academy of Sciences of the GDR, Berlin-Buch.
Sydow
H
H
Rücker
K
K
D000818:Animals; D005260:Female; D007114:Immunization; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D012016:Reference Values; D012794:Sialic Acids / Q000097:blood*; D013045:Species Specificity
D012794:Sialic Acids