Investigation of lipid peroxidation induced by hydrazine compounds in vivo in the rat.
Phenylhydrazine caused lipid peroxidation in rats in vivo as detected by expiration of ethane but this was not due to lipid peroxidation in liver, as there was no associated MDA production in this tissue. Hydrazine did not cause either ethane expiration or MDA formation. Both hydrazine and phenylhydrazine caused a significant increase in propane expiration. Phenylhydrazine significantly decreased packed cell volume and haemoglobin levels but hydrazine had no effect on these parameters. These data indicate that the early toxicity of hydrazine does not involve peroxidation of lipids whereas phenylhydrazine causes lipid peroxidation possibly within the erythrocyte, perhaps by interaction with red cell haemoglobin.
Preece
N E
NE
Department of Pharmacology School of Pharmacy, University of London, U.K.
Timbrell
J A
JA
D000473:Alkanes / Q000378:metabolism; D000818:Animals; D001772:Blood Cell Count; D004906:Erythrocyte Count; D006454:Hemoglobins / Q000378:metabolism; D006834:Hydrazines / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000096:biosynthesis; D010659:Phenylhydrazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000473:Alkanes; D006454:Hemoglobins; D006834:Hydrazines; D010659:Phenylhydrazines; D008315:Malondialdehyde