title: Safety and tolerance of ocular administration of recombinant alpha interferon.
abstract: The safety, tolerance, and levels of drug in the nasal cavity produced by an ocular formulation of interferon were determined at four dosages in a placebo-controlled, double-masked trial. Interferon given by the ocular route was generally well tolerated, although a dose-related occurrence of subjective symptoms was detected.
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84132.
authors.forename: R B
authors.initials: RB
authors.lastname: Turner
authors.forename: F J
authors.initials: FJ
authors.lastname: Durcan
authors.forename: J K
authors.initials: JK
authors.lastname: Albrecht
authors.forename: A S
authors.initials: AS
authors.lastname: Crandall
mesh_terms: D000328:Adult; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D009297:Nasal Mucosa / Q000378:metabolism; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins
chemical_list: D007370:Interferon Type I; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins