A longitudinal study of circulating progesterone, oestradiol, hCG and hPL during pregnancy in type 1 diabetic mothers.
Serum progesterone, oestradiol, human chorionic gonadotrophin (hCG) and human placental lactogen (hPL) were determined serially throughout 27 pregnancies in insulin-dependent diabetic patients from Newcastle (UK), 15 such patients from Stockholm (Sweden) and in 69 normal women having uncomplicated pregnancies. Mean progesterone, oestradiol and hCG concentrations were somewhat higher in the diabetic women during the third trimester but hPL values were not different from normal. The increased hormone concentrations did not relate to the increased birthweights or placental weights in the diabetic women. It is suggested that the usual physiological endocrine changes during normal pregnancy are relatively undisturbed by insulin-dependent diabetes or the degree of diabetes control achieved.
Stewart
M O
MO
Princess Mary Maternity Hospital, Newcastle upon Tyne.
Whittaker
P G
PG
Persson
B
B
Hanson
U
U
Lind
T
T
D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D006063:Chorionic Gonadotropin / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology; D010928:Placental Lactogen / Q000097:blood*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D011374:Progesterone / Q000097:blood*; D013997:Time Factors
D001786:Blood Glucose; D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol; D010928:Placental Lactogen