title: Experience of splenectomy and cholecystectomy in children with chronic haemolytic anaemia.
abstract: Since 1973, 419 children (233 boys, 186 girls) with chronic haemolytic anaemia (mean age, 10.2 +/- 3.5 years) have been splenectomised. Fifty-three (12.6%) have also been cholecystectomised because of cholelithiasis. Between 1973 and 1982, cholecystectomy and splenectomy were performed at the same time in symptomatic patients. Later, between 1983 and 1987, cholecystectomy was also performed in clinically asymptomatic patients with positive sonographic findings. In the first period, 11 thalassaemic patients (45.8%) were cholecystectomised a short period after splenectomy (in two cases, only 2 and 3 weeks later). Between 1983 and 1987, when asymptomatic patients with cholelithiasis were screened by sonography, simultaneous cholecystectomy and splenectomy were performed in 13.6% of the patients with thalassaemia, in 41% of the patients with sickle cell or microdrepanocytic disease, and in 22.2% of the patients with spherocytosis. As there is a high incidence of asymptomatic cholelithiasis and hypersplenism in patients with chronic haemolytic anaemia, screening for gallstones should precede splenectomy. Simultaneous cholecystectomy should be performed in patients with cholelithiasis.
authors.affiliation: First Paediatric Surgery Department, Aghia Sophia Children's Hospital, Athens, Greece.
authors.forename: C H
authors.initials: CH
authors.lastname: Pappis
authors.forename: S
authors.initials: S
authors.lastname: Galanakis
authors.forename: G
authors.initials: G
authors.lastname: Moussatos
authors.forename: D
authors.initials: D
authors.lastname: Keramidas
authors.forename: C
authors.initials: C
authors.lastname: Kattamis
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000743:Anemia, Hemolytic / Q000150:complications* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000175:diagnosis / Q000209:etiology*; D002908:Chronic Disease; D005260:Female; D006115:Greece; D006801:Humans; D007223:Infant; D008297:Male; D012008:Recurrence; D013156:Splenectomy