6-Desmethoxyhormothamnione, a new cytotoxic styrylchromone from the marine cryptophyte Chrysophaeum taylori.
Our previous chemical investigations of a yellow marine alga from Puerto Rico, tentatively identified as the tuft-forming cyanobacterium Hormothamnion enteromorphoides, led to the isolation of a structurally novel cytotoxic styrylchromone natural product, hormothamnione [2]. Continued chemical work with this organism has resulted in the isolation and spectroscopic structure elucidation of a closely related styrylchromone, 6-desmethoxyhormothamnione [1], which is also cytotoxic to cancer cells. The substitution pattern of proton, hydroxyl, and methoxyl groups on the chromone ring was established by long range 1H-13C heteronuclear correlation spectroscopy. The taxonomy of the source organism for these styrylchromone natural products, 1 and 2, is revised to the marine cryptophyte Chrysophaeum taylori as a result of detailed microscopic and cultural efforts.
Gerwick
W H
WH
College of Pharmacy, Oregon State University, Corvallis 97331.
D000970:Antineoplastic Agents / Q000032:analysis / Q000302:isolation & purification; D055598:Chemical Phenomena; D002621:Chemistry; D002867:Chromones / Q000032:analysis / Q000302:isolation & purification*; D056890:Eukaryota / Q000032:analysis*
D000970:Antineoplastic Agents; D002867:Chromones; C060394:6-desmethoxyhormothamnione