How is the NaCl signal transmitted in NaCl-induced hypertension?
Is the NaCl signal perceived as a small increase in the concentration of NaCl in extracellular fluid? We used 8 g NaCl/100 g soluble nutrients and fed only a hypertonic (1.4% NaCl) or a hypotonic (0.45% NaCl) drink to Dahl salt-sensitive (DS) rats. After 12 weeks, 11 rats receiving the hypertonic drink had a mean blood pressure of 195 mm Hg versus 195 mm Hg in 12 rats receiving the hypotonic drink. Thus, the high-NaCl signal seems unrelated to a higher NaCl concentration in extracellular fluid, thereby suggesting volume signals. Most volume controls are near the third brain ventricle (3V). As a working hypothesis, high dietary NaCl may swell the tissues surrounding 3V, which is slitlike. Such swelling would partially close the upper part of the slit and cause ependymal cells and nerve fibers on opposite walls to touch, possibly leading to hypertension in susceptible humans or rats. To test this, we stereotaxically blocked the aqueduct with inert silicone to produce hydrocephalus of 3V in DS rats and thus prevent ependymal cells and nerve fibers from touching. After blocking or sham-blocking the aqueduct, either a 6% NaCl diet or a 0.23% NaCl diet was started. Intra-arterial blood pressure was taken after 6 weeks. A group of 28 sham-blocked rats and a group of 29 blocked rats, all fed a 0.23% low NaCl diet, had equal blood pressures averaging 130 mm Hg.(ABSTRACT TRUNCATED AT 250 WORDS)
Lee
J Y
JY
University of Minnesota Hospital, Minneapolis, Minnesota 55455.
Tobian
L
L
Hanlon
S
S
Hamer
R
R
Johnson
M A
MA
Iwai
J
J
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002535:Cerebral Aqueduct / Q000473:pathology; D004351:Drug Resistance; D006973:Hypertension / Q000139:chemically induced* / Q000503:physiopathology; D019736:Prostheses and Implants; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic; D015398:Signal Transduction; D012828:Silicones; D012965:Sodium Chloride / Q000502:physiology*
D012462:Saline Solution, Hypertonic; D012828:Silicones; D012965:Sodium Chloride