[Changes in catecholamines of the striatum during 5% oxygen administration and the alleviating effects of flunarizine in rats].
Five percent oxygen was administered to rats under controlled respiration. The concentrations of catecholamines and their metabolites (dopamine, HVA, DOPAC, norepinephrine) were measured during 5% oxygen administration and subsequent recovery period. Flunarizine, a calcium channel blocker, was administered and its effects on catecholamine fluctuations were studied. Results were as follows. Dopamine increased with 5% oxygen administration. DOPAC and norepinephrine decreased and no changes were seen in HVA. After 20 min of hypoxia, catecholamine contents returned to the control levels in another 2 hours of air breathing. When flunarizine was administered in advance, changes in catecholamine content appeared to be lower during 5% oxygen administration and subsequent recovery period.
Yamazaki
M
M
Masuda
T
T
Ito
Y
Y
Miyazaki
H
H
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D005444:Flunarizine / Q000627:therapeutic use*; D000860:Hypoxia / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines; D005444:Flunarizine