title: Designing clinical trials for two-sided multiple comparisons with a control.
abstract: When a clinical trial is to be conducted to compare more than one experimental treatment to a control treatment, Dunnett's two-sided multiple comparison procedure may be proposed to perform the analysis. During the planning stage, the problem of determining the appropriate sample size must be resolved. Here a solution to this problem is derived by controlling the power of the corresponding testing procedure that assumes that the common variance is known.
authors.affiliation: Pharmaceuticals Division, CIBA-GEIGY Corporation, Summit, NJ 07901.
authors.forename: D R
authors.initials: DR
authors.lastname: Bristol
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D011381:Programming Languages; D012107:Research Design; D012494:Sampling Studies; D013223:Statistics as Topic