title: Trimethoprim-sulphadiazine prophylaxis in children with vesico-ureteric reflux.
abstract: The efficacy of long-term low-dose prophylaxis with co-trimazine (1-2 mg trimethoprim and 4.5-9 mg sulphadiazine per kg body weight) was studied in 55 children with dilated vesico-ureteric reflux. Of 44 girls, there were 13 with break-through urinary tract infection, all caused by resistant bacteria and in all but one case of pyelonephritic type. The recurrence rate was 1.5/100 treatment months. In 11 boys, there were no break-through infections in 311 treatment months. Co-trimazine was thus an effective drug for prevention of urinary tract infection in this high-risk population.
authors.affiliation: Department of Paediatric Surgery, University of Göteborg, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Hanson
authors.forename: S
authors.initials: S
authors.lastname: Hansson
authors.forename: U
authors.initials: U
authors.lastname: Jodal
mesh_terms: D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012008:Recurrence; D013411:Sulfadiazine / Q000627:therapeutic use*; D013997:Time Factors; D014295:Trimethoprim / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000209:etiology / Q000517:prevention & control*; D014718:Vesico-Ureteral Reflux / Q000150:complications*; D000096926:Benzenesulfonamides
chemical_list: D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D013411:Sulfadiazine; D014295:Trimethoprim; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides