Effects of mace (Myristica fragrans, Houtt.) on cytosolic glutathione S-transferase activity and acid soluble sulfhydryl level in mouse liver.
The aril of plant Myristica fragrans Houtt. commonly known as mace, which is consumed as a spice as well as used as a folk-medicine, was screened for its effects on the levels of cytosolic glutathione S-transferase (GST) and acid-soluble sulfhydryl (SH) groups in the liver of young adult male and female Swiss albino mice. Animals were assorted into 4 groups comprised of either sex and received either normal diet (negative control), 1% 2,3-tert-butyl-4-hydroxyanisole (BHA) diet (positive control), 1% mace diet or 2% mace diet for 10 days. There was a significant increase in the GST activity in the liver of mice exposed to BHA or mace. In addition, there was a significant increase in the SH content in the liver of mice fed on 1% BHA and 2% mace diets.
Kumari
M V
MV
Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Rao
A R
AR
D000818:Animals; D003212:Condiments; D003600:Cytosol / Q000378:metabolism; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D012737:Sex Factors; D013438:Sulfhydryl Compounds / Q000378:metabolism*
D013438:Sulfhydryl Compounds; D005982:Glutathione Transferase