title: Has bovine somatotropin (BST) an effect upon drug disposition? Comparative studies in goats and cattle with sulphadimidine and antipyrine after parenteral administration of BST, zeranol and proligestone.
abstract: Daily subcutaneous BST injection in lactating cows, bulls and castrated male dwarf goats did not induce significant changes in the pharmacokinetic parameters of antipyrine (AP) and sulphadimidine (SDD). Similarly, no changes were obtained after injection of slow-release BST formulations in lactating cows and non-lactating female goats. In contrast to androgenic hormones, both zeranol and proligestone had no effect upon the disposition of AP and SDD, although both synthetic hormones did induce enhanced plasma somatotropin concentrations. In goats, metabolic effects induced by zeranol and BST included significant reductions in plasma urea values, whereas plasma creatinine levels were somewhat lower after daily BST administration.
authors.affiliation: Department of Veterinary Basic Sciences, Faculty of Veterinary Medicine, Utrecht State University, The Netherlands.
authors.forename: R F
authors.initials: RF
authors.lastname: Witkamp
authors.forename: S M
authors.initials: SM
authors.lastname: Nijmeijer
authors.forename: C T
authors.initials: CT
authors.lastname: Van Duin
authors.forename: M M
authors.initials: MM
authors.lastname: Bevers
authors.forename: T
authors.initials: T
authors.lastname: Wensing
authors.forename: H
authors.initials: H
authors.lastname: Van Gogh
authors.forename: A S
authors.initials: AS
authors.lastname: Van Miert
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics*; D002417:Cattle / Q000378:metabolism*; D003404:Creatinine / Q000097:blood; D005260:Female; D006041:Goats / Q000378:metabolism*; D013006:Growth Hormone / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D011374:Progesterone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D013418:Sulfamethazine / Q000493:pharmacokinetics*; D014508:Urea / Q000097:blood; D015029:Zeranol / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D013418:Sulfamethazine; D011374:Progesterone; C017677:proligestone; D015029:Zeranol; D014508:Urea; D013006:Growth Hormone; D003404:Creatinine; D000983:Antipyrine