title: Use of patellar tendon autograft for anterior cruciate ligament reconstruction in the rabbit: a long-term histologic and biomechanical study.
abstract: To assess the degree of success of anterior cruciate ligament (ACL) replacement using the patellar tendon (PT) autograft, 29 New Zealand white rabbits underwent ACL reconstruction using a medial one-third PT autograft. The femur-ligament-tibia complexes were evaluated at 0, 6, 30, and 52 weeks postoperatively for gross and histologic appearances and tensile load to failure properties. Grossly, the autografts did not resemble the control ACLs. Histologically, the autografts progressed from being hypercellular with a random collagen fiber bundle organization to having a near normal cellularity with a more parallel collagen fiber bundle pattern. Anteroposterior knee laxity was more than two times that of the control knees 52 weeks after reconstruction. Biomechanically, the PT autografts plateaued at 30 weeks postoperatively. The ultimate load and stiffness were 15 +/- 5% and 24 +/- 6% of the control ACLs, respectively. At 52 weeks, the appearance of the PT autograft had some general histologic similarities as compared with the native ACL. However, these similarities did not extend to the functional properties of the autograft.
authors.affiliation: Orthopaedic Bioengineering Laboratory, University of California, San Diego, La Jolla 92093.
authors.forename: R T
authors.initials: RT
authors.lastname: Ballock
authors.forename: S L
authors.initials: SL
authors.lastname: Woo
authors.forename: R M
authors.initials: RM
authors.lastname: Lyon
authors.forename: J M
authors.initials: JM
authors.lastname: Hollis
authors.forename: W H
authors.initials: WH
authors.lastname: Akeson
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D005269:Femur / Q000473:pathology; D007719:Knee Joint / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008023:Ligaments, Articular / Q000473:pathology / Q000601:surgery*; D008488:Medical Illustration; D009983:Orthopedic Equipment; D010329:Patella; D011817:Rabbits; D013710:Tendons / Q000637:transplantation*; D013977:Tibia / Q000473:pathology; D014182:Transplantation, Autologous