title: [Oxygen status of arterial blood including uncompensated mixed venous oxygen tension and cardial oxygen compensation factor. Reevaluation on the basis of 250 arterial punctures].
abstract: In arterial blood from 250 patients we measured pH, pco2, and po2 (electrochemically) together with total-hemoglobin concentration, oxygen saturation, carboxy- and methemoglobin fractions (spectrometrically). With a previously published algorithm we calculated the effective hemoglobin concentration, total-oxygen concentration, half saturation tension, erythrocyte 2,3-diphosphoglycerate concentration, and two new oxygen parameters: uncompensated mixed venous oxygen tension and cardiac oxygen compensation factor. 11% of the patients have normal arterial oxygen tension, but nevertheless risk of tissue hypoxia judged from the two new oxygen parameters. This is due to a low hemoglobin concentration and/or low half saturation tension (increased hemoglobin oxygen affinity). Some patients have decreased arterial oxygen tension but normal uncompensated mixed venous oxygen tension (15%) or normal cardiac oxygen compensation factor (9%). This is due to a high hemoglobin concentration and/or increased half saturation tension. The latter varies from 2.6 to 5.2 kPa (ref.: 3.3-3.9 kPa); 36% have decreased, 27% increased values. The 2,3-diphospho-glycerate concentration varies from 2.0 to 7.9 mmol/l (ref.: 3.6-5.1 mmol/l); 14% have decreased, 30% increased values. Uncompensated mixed venous oxygen tension varies from 1.8 to 5.7 kPa (ref.: 4.5-5.5 kPaf). The cardiac oxygen compensation factor varies from 0.9 to infinity (ref.: 0.8-1.6). We conclude that the variation in the different oxygen parameters is so significant that it justifies routine calculation for all arterial blood samples where the measurement on a conventional blood gas analyzer is supplemented with measurement on one of the new multi-wavelength hemoximeters. The calculation algorithm permits calculation of all the oxygen parameters for the majority of arterial samples (84%) where the oxygen saturation is less than or equal to 0.970.
authors.forename: E
authors.initials: E
authors.lastname: Jensen
authors.forename: O
authors.initials: O
authors.lastname: Siggaard-Andersen
authors.forename: H
authors.initials: H
authors.lastname: Berg
authors.forename: P D
authors.initials: PD
authors.lastname: Wimberley
authors.forename: N
authors.initials: N
authors.lastname: Fogh-Andersen
mesh_terms: D000328:Adult; D000368:Aged; D001158:Arteries; D001800:Blood Specimen Collection; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D014680:Veins
chemical_list: D006454:Hemoglobins; D010100:Oxygen
vernacular_title: Arterieblodets oxygenstatus, herunder ukompenseret blandetvenøs oxygentension og kardial oxygenkompensationsfaktor. Nyvurdering på basis of 250 arteriepunkturer.