title: Metabolism of pyrazinamide and allopurinol in hereditary xanthine oxidase deficiency.
abstract: The metabolism of pyrazinamide and allopurinol was studied in three xanthinuric patients from two families with hereditary xanthinuria to determine whether both substrates were oxidized only by xanthine oxidase or by other oxidases as well. One xanthinuric patient could neither metabolize pyrazinamide into 5-hydroxypyrazinamide nor allopurinol into oxypurinol. Two xanthinuric patients could metabolize both pyrazinamide into 5-hydroxypyrazinamide and allopurinol into oxypurinol but could not oxidize pyrazinoic acid to 5-hydroxypyrazinoic acid. These findings suggest that xanthinuria comprises at least two subgroups.
authors.affiliation: The Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Higashino
authors.forename: N
authors.initials: N
authors.lastname: Kono
authors.forename: M
authors.initials: M
authors.lastname: Kawachi
authors.forename: M
authors.initials: M
authors.lastname: Nanahoshi
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Suda
authors.forename: T
authors.initials: T
authors.lastname: Hada
mesh_terms: D000328:Adult; D000493:Allopurinol / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D011686:Purine-Pyrimidine Metabolism, Inborn Errors / Q000145:classification / Q000201:enzymology / Q000378:metabolism*; D011718:Pyrazinamide / Q000378:metabolism* / Q000652:urine; D014970:Xanthines / Q000652:urine*
chemical_list: D014970:Xanthines; D011718:Pyrazinamide; D000493:Allopurinol