[Erythrocyte membrane permeability for univalent cations (Na+, K+) and their transformation in patients with hypertension and symptomatic (renal) hypertension].
The form and surface architectonic of erythrocytes studied in 18 teenagers and men with hypertensive disease of I stage (HD) and in 7 men with symptomatic (renal) hypertension (SH). Simultaneously permeability of erythrocyte membranes for Na+ and K+ was studies. The change in the form and surface architectonics was found in the erythrocytes of the patients with hypertensive disease, I stage. The same was true for the patients with renal hypertension but the difference was not so prominent. Rapid shift of correlation of erythrocyte morphological varieties has been revealed during the study of Na+ and K+ ions' transport rate after the treatment by p-chloromercuribenzoate acid. Increase of irreversible transformation of erythrocytes was discovered in patients with HD. Besides in some cases there was decrease in the size of echinocytes. The transformation of erythrocytes into echinocytes is more prominent in healthy subjects and in patients with SH. Our data suggest that the change in erythrocyte form is related to the change of erythrocyte membrane permeability to Na+ and K+ ions and the alteration of membrane structure is the basis for these disturbances.
Kavtaradze
V G
VG
Aleksidze
N G
NG
Nadiradze
N I
NI
Cheĭshvili
L D
LD
D000293:Adolescent; D000328:Adult; D002463:Cell Membrane Permeability / Q000187:drug effects; D002729:Chloromercuribenzoates / Q000494:pharmacology; D004906:Erythrocyte Count / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D006977:Hypertension, Renal / Q000097:blood*; D066298:In Vitro Techniques; D008297:Male; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*; D013499:Surface Properties
D002729:Chloromercuribenzoates; D012964:Sodium; D011188:Potassium
Pronitsaemost' membran éritrotsitov dlia odnovalentnykh kationov (Na+, K+) i ikh transformatsiia u bol'nykh gipertonicheskoĭ bolezn'iu i simptomaticheskoĭ (pochechnoĭ) gipertenzieĭ.