Acute acid aspiration lung injury in the rat: biphasic pathogenesis.
The purpose of this study was to develop a reproducible model of acute acid aspiration-induced lung injury in the rat to explore the pathophysiology of aspiration pneumonitis. A biphasic injury pattern was observed with injury peaks at 1 hr and 4 hr. Histologic studies at 4 hr revealed significant increases in neutrophils in the alveolar interstitial space. These studies suggest that acid aspiration results in a biphasic acute injury. We hypothesize that the first phase results from a direct physiochemical process or is mediated via afferent (capsaicin sensitive) nerves or both. The second phase, occurring 2-3 hr later, is mediated by neutrophils and is consistent with an acute inflammatory response.
Kennedy
T P
TP
Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor 48109.
Johnson
K J
KJ
Kunkel
R G
RG
Ward
P A
PA
Knight
P R
PR
Finch
J S
JS
D000818:Animals; D002199:Capillary Permeability; D006863:Hydrogen-Ion Concentration; D008297:Male; D011015:Pneumonia, Aspiration / Q000473:pathology / Q000503:physiopathology*; D051381:Rats