Treatment of chronic liver injury in mice by oral administration of xiao-chai-hu-tang.
Oral administration of Xiao-Chai-Hu-Tang, the extract of a mixture of seven herbs, attenuated the hepatic fibrosis developed in mice after repeated doses of carbon tetrachloride. Its pre-administration reduced the derangement of liver function tests seen after a single dose of carbon tetrachloride as well as that seen after d-galactosamine intoxication. Xiao-Chai-Hu-Tang may be effective in the treatment of chronic liver injury through hepatocytoprotection.
Amagaya
S
S
Faculty of Pharmaceutical Science, Nagoya City University, Japan.
Hayakawa
M
M
Ogihara
Y
Y
Ohta
Y
Y
Fujiwara
K
K
Oka
H
H
Oshio
H
H
Kishi
T
T
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005688:Galactosamine / Q000506:poisoning; D006909:Hydroxyproline / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011517:Prothrombin Time
D004365:Drugs, Chinese Herbal; C018142:saiko-keishi-to; D005688:Galactosamine; D000410:Alanine Transaminase; D006909:Hydroxyproline