title: [Value of nifedipine in respiratory failure related to obstructive chronic bronchitis during treatment over 6 months].
abstract: We studied the simultaneous effects of nifedipine on the pulmonary circulation and blood gases in 12 patients with pulmonary hypertension secondary to obstructive chronic bronchitis. Measurements were carried out at rest and during stress, initially then one hour after administration of 20 mg of nifedipine sublingually. They were repeated in a similar fashion after a 6-month treatment with 60 mg/day (group II) (30 mg/day in case of intolerance) (group I). The results of the immediate effect of nifedipine are in favor of a passive pulmonary vasodilatation secondary to the systemic vasodilatation. After six months of treatment, the pulmonary vasodilatation persists, but is associated with a decreased motor pressure indicating a more specific and more active pulmonary vasodilating effect of long-term nifedipine, especially during stress; this results in the improvement of the performance of the right ventricle without harmful effect on the blood gases. However, these results should be interpreted with caution on account of the small number of patients, the large interindividual variations and the absence of a reference population.
authors.affiliation: Service de Pneumophtisiologie, CHU La Milétrie, Poitiers.
authors.forename: J C
authors.initials: JC
authors.lastname: Meurice
authors.forename: P
authors.initials: P
authors.lastname: Boutaud
authors.forename: D
authors.initials: D
authors.lastname: Herpin
authors.forename: P
authors.initials: P
authors.lastname: Ingrand
authors.forename: F
authors.initials: F
authors.lastname: Boita
authors.forename: M
authors.initials: M
authors.lastname: Underner
authors.forename: F
authors.initials: F
authors.lastname: Patte
mesh_terms: D000286:Administration, Sublingual; D004334:Drug Administration Schedule; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology; D008173:Lung Diseases, Obstructive / Q000150:complications; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011652:Pulmonary Circulation / Q000187:drug effects*; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D012131:Respiratory Insufficiency / Q000209:etiology
chemical_list: D009543:Nifedipine
vernacular_title: Intérêt de la nifédipine dans l'insuffisance respiratoire liée aux bronchites chroniques obstructives au cours d'un traitement de six mois.