[Genetic variants of the complement components and HLA-antigens associated in patients with psoriasis vulgaris in Japanese].
Genetic polymorphisms of the serum complement components (C2, C4, C6, and C7) and HLA-antigens were studied in Japanese patients with psoriasis vulgaris. Among these complement components, positive associations with C4A4 and C4B2 were obtained. In addition to the previously reported haplotypes HLA-Cw6-B13 and Cw6-Bw57-DR7, the extended haplotype HLA-Cw11-Bw46-C4A4. 4B2-BFS-C2C-DRw8 may be a high risk haplotype in Japanese patients with psoriasis vulgaris.
Nakagawa
H
H
Tokunaga
K
K
Dewald
G
G
Omoto
K
K
Ishibashi
Y
Y
Matsuki
K
K
Juji
T
T
D044466:Asian People; D003165:Complement System Proteins / Q000235:genetics*; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000235:genetics*; D012306:Risk
D006680:HLA Antigens; D003165:Complement System Proteins