[Transplantability and immunogenicity in mice of lymphoma Nk/Ly cells modified by concanavalin A and neuraminidase].
The modifying effect of con A, Vibrio cholerae and non-Vibrio cholerae neuraminidase (VCN, NVCN) on the proliferative potential and immunogenicity of experimental lymphoma NK/Ly cells is shown in vitro and in vivo. The efficacy of immunization by the modified tumour cells of mice with transplantable lymphoma is evaluated. A considerable decrease in the proliferative potential of transplantability and a moderate increase in immunogenicity of Con A treated cells were determined in vitro. The high immunogenicity of VCN-modified cells was found within the limits of the studied immunologic parameters. However, the VCN-MTC immunotherapy had no advantages over Con A-MTC immunotherapy. It is found that the modifying effect of NVCN on a tumour cell is inferior to the effect of Con A and VCN.
Bratus'
G G
GG
Darchuk
G F
GF
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology*; D005260:Female; D007111:Immunity, Cellular; D007114:Immunization / Q000379:methods; D007958:Leukocyte Count; D008223:Lymphoma / Q000209:etiology* / Q000276:immunology; D051379:Mice; D008806:Mice, Inbred AKR; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009439:Neuraminidase / Q000494:pharmacology*; D012397:Rosette Formation; D014407:Tumor Cells, Cultured; D014733:Vibrio / Q000201:enzymology; D014734:Vibrio cholerae / Q000201:enzymology
D003208:Concanavalin A; D009439:Neuraminidase
Perevivaemost' i immunogennost' modifitsirovannykh konkanavalinom A i neĭraminidazoĭ kletok limfomy Nk/Ly u mysheĭ.