Comparison of intramuscular nalbuphine and nicomorphine in the treatment of post-operative pain.
Nalbuphine and nicomorphine were administered intramusculary in single doses for the relief of moderate to severe pain after abdominal surgery in a group of 40 patients to compare the analgesic effect and clinical tolerance during a 2 hour period. There was no statistically significant difference of the analgesic effect. In both groups SBP, DBP and RR decreased and HR increased significantly after injection but the tolerance of nalbuphine seems to be beter. Nalbuphine is a good choice for postoperative pain.
Admiraal
P V
PV
Dept. of Anesthesiology, Reinier de Graaf Gasthuis, Delft.
Wozniak
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S
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009019:Morphinans / Q000627:therapeutic use*; D009022:Morphine Derivatives / Q000008:administration & dosage / Q000627:therapeutic use*; D009266:Nalbuphine / Q000008:administration & dosage / Q000627:therapeutic use*; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*; D012119:Respiration / Q000187:drug effects
D009019:Morphinans; D009022:Morphine Derivatives; D009539:Nicotinic Acids; D009266:Nalbuphine; C008549:nicomorphine