title: [Synthesis and cytostatic action of 9-nitronoracronycine].
abstract: The synthesis of 9-nitronoracronycine (12) from 1,3-dihydroxy-10-methyl-7-nitroacridone (4) and 2-chlor-2-methyl-3-butyne is reported. Screening tests with the transplantation tumor leukemia P 388 proved 4 and 1-methoxy-10-methyl-7-nitroacridone (14) to be inactive. 12 and 3-methoxy-10-methyl-7-nitroacridone (15) showed cytotoxicity in higher doses. Structure-activity relationships are discussed.
authors.forename: J
authors.initials: J
authors.lastname: Reisch
authors.forename: W
authors.initials: W
authors.lastname: Probst
mesh_terms: D000175:Acronine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000470:Alkaloids / Q000138:chemical synthesis*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; C059842:9-nitronoracronycine; D000175:Acronine
vernacular_title: Synthese und cytostatische Wirkung des 9-Nitronoracronycins.