Catastrophic neurologic signs due to drug interaction: Tegretol and Darvon.
Eight cases of carbamazepine toxicity from interaction with propoxyphene are reported. Serum concentrations of carbamazepine increased up to sixfold. All patients were symptomatic and two were hospitalized. Practitioners prescribing propoxyphene acutely for pain should be aware of this significant interaction.
Oles
K S
KS
Department of Neurology, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.
Mirza
W
W
Penry
J K
JK
D000328:Adult; D002220:Carbamazepine / Q000009:adverse effects* / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics; D011431:Dextropropoxyphene / Q000009:adverse effects* / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced*
D002220:Carbamazepine; D011431:Dextropropoxyphene