[Diffusion of sulbactam and cefoperazone into the prostatic tissue].
Diffusion of sulperazone (SBT) and cefoperazone (CPZ) into the prostatic tissue was studied in 20 cases. Two g of SBT/CPZ was injected intravenously and 1 hour later, prostatic tissue was obtained surgically and venous blood was drawn simultaneously. The serum concentration of CPZ (58.0 micrograms/ml +9.2) was higher than that of SBT (25.9 micrograms/ml +/- 9.3) and the prostatic tissue concentration of CPZ (14.9 micrograms/ml +/- 6.1) was higher than that of SBT (10.9 micrograms +/- 6.1). However, the SBT concentration ratio of prostatic tissue to serum level (P/S ratio) was significantly higher (42.5%) than that of CPZ (25.9%). The SBT concentration in the prostatic tissue was high enough to enhance the antibacterial activity of CPZ. SBT/CPZ was appraised to be an effective chemotherapeutic agent for infections of prostate caused by susceptible organisms, especially by beta-lactamase producing bacteria.
Okamura
K
K
Department of Urology, Asahikawa Medical College.
Hashimoto
H
H
Morikawa
M
M
Saga
Y
Y
Nishimoto
M
M
Yachiku
S
S
Osani
H
H
Yamauchi
K
K
D000368:Aged; D000369:Aged, 80 and over; D002438:Cefoperazone / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism*; D013407:Sulbactam / Q000097:blood / Q000493:pharmacokinetics*
D002438:Cefoperazone; D013407:Sulbactam