The swine leucocyte antigen (SLA) complex and Sinclair swine cutaneous malignant melanoma.
Cutaneous malignant melanoma of Sinclair swine (SSCM) is an inherited neoplasm present at birth in a majority of affected animals. We have characterized the swine leucocyte antigen (SLA) complex of the Sinclair herd at Texas A & M University using a one-way mixed lymphocyte test and found that one particular haplotype, arbitrarily identified as haplotype B, is associated with the expression of SSCM. Only a single dose of the B haplotype is required for a dominant allele at a 'tumour initiator' locus to be fully penetrant. In addition, swine homozygous for haplotype B develop more primary tumours between birth and weaning than those heterozygous for the B haplotype. Taken together, these findings indicate that tumour initiation, in utero, and expression between birth and weaning may involve different mechanisms.
Tissot
R G
RG
Department of Genetics, University of Illinois College of Medicine, Chicago.
Beattie
C W
CW
Amoss
M S
MS
D000818:Animals; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D008545:Melanoma / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D013552:Swine / Q000235:genetics* / Q000276:immunology; D013553:Swine Diseases / Q000235:genetics*
D015395:Histocompatibility Antigens Class I