[The effect of prostaglandin F2 alpha and indomethacin on the musculature of the human appendix].
In their research, the authors have tried to determine possible differences in effects of prostaglandin F2 alpha on longitudinal musculature tonus in normal and inflamed human appendix and the extent to which it is possible to react on prostaglandin effect by indomethacin. The obtained results indicate that PGF2 alpha increases tonus in human appendix musculature; however, the change is more pronounced in a normal appendix musculature. Even more, indomethacin prevents spasms caused by PGF2 alpha in musculature of both normal and inflamed appendix significantly. This indicates that, in addition to its influence on prostaglandin synthesis indomethacin also has another mechanism of activity, may be even at the level of prostaglandin receptors.
Frković
A
A
Frković
A
A
Atanacković
D
D
D001065:Appendix / Q000187:drug effects* / Q000502:physiology; D015237:Dinoprost / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D009129:Muscle Tonus / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*
D015237:Dinoprost; D007213:Indomethacin
Utjecaj prostaglandina F2 alpha i indometacina na muskulaturu humanog apendiksa.