Quinine dosage in severe malaria with renal failure necessitating haemodialysis.
For therapy of severe malaria with renal failure, a 2/3 reduction in the usual intravenous dose of quinine is recommended (600 mg per 24 h instead of 600 mg per 8 h). Two patients with severe malaria and renal failure requiring dialysis have been treated. The half-life was not prolonged (15 h). Quinine proved to be nondialysable. It was shown that this dose of quinine tended to lead to a low level in blood (under 10 mg.l-1). A normal dose of quinine (2 x 15 mg/kg per day) is therefore recommended for malaria therapy, even in cases with renal failure requiring haemodialysis, in order to attain the desired plasma level (5 to 15 mg.l-1).
Sharma
A M
AM
Department of General Internal Medicine and Nephrology, Steglitz Hospital, Free University of Berlin.
Keller
F
F
Boeckh
M
M
Heitz
J
J
Borner
K
K
D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008288:Malaria / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011803:Quinine / Q000008:administration & dosage / Q000627:therapeutic use*; D006435:Renal Dialysis
D011803:Quinine