Effect of glycyl-L-glutamine on the rate of regeneration of acetylcholinesterase in the rat gastrocnemius muscle after diisopropyl phosphorofluoridate administration.
Rats were given glycyl-L-glutamine (Gly-Gln) by intraaortic infusion with Alzet osmotic pumps during the 48-hr period following the intraaortic administration of diisopropyl phosphorofluoridate (DFP) (10 mumol/kg). The infusion of 1.2 mumol of Gly-Gln per 24 hr resulted in a significant increase in the acetylcholinesterase (AcChoEase; acetylcholine acetylhydrolase, EC 3.1.1.7) activity of the gastrocnemius muscles over that of rats that received DFP only. At a total dose of 3.6 mumol per 24 hr, a diminished result was obtained; at 0.36 mumol per 24 hr, no effect was detectable. These findings, together with earlier ones, suggest that the neurotrophic effect of Gly-Gln or a similar endogenous factor on AcChoEase synthesis is a general phenomenon at sites of cholinergic transmission.
Koelle
G B
GB
Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia 19104-6084.
Han
M S
MS
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D007531:Isoflurophate / Q000494:pharmacology*; D007700:Kinetics; D009132:Muscles / Q000187:drug effects / Q000201:enzymology*; D009433:Neural Inhibition; D051381:Rats; D012016:Reference Values; D013997:Time Factors
D004151:Dipeptides; D007531:Isoflurophate; C039788:glycylglutamine; D000110:Acetylcholinesterase