Effect of kallikrein on the Sertoli cell function.
The effect of kallikrein on the Sertoli cells was investigated to determine the rat testicular androgen binding component (ABC = androgen binding protein + androgen receptor) concentration using the dextran-coated charcoal method. The results showed that the concentrations of testicular ABC were increased significantly by the administration of kallikrein to levels approaching those seen after stimulation by LH-RH or FSH. Therefore, it is suggested that kallikrein has an effect that influences the Sertoli cells directly or indirectly.
Saito
S
S
Department of Urology, Sapporo Medical College, Japan.
Mikuma
N
N
Kumamoto
Y
Y
D000727:Androgen-Binding Protein / Q000378:metabolism; D000818:Animals; D007610:Kallikreins / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011944:Receptors, Androgen / Q000187:drug effects; D012708:Sertoli Cells / Q000187:drug effects*
D000727:Androgen-Binding Protein; D011944:Receptors, Androgen; D007610:Kallikreins