title: Effects of clozapine on ketamine-induced linguopharyngeal events in rats.
abstract: We tested the effects of clozapine (0.02-20 mg/kg i.p.) on ketamine-induced linguopharyngeal events in rats anesthetized with i.m. injections of ketamine hydrochloride (100 mg/kg) and mounted on a stereotaxic with the tip of the tongue tied to a force displacement transducer monitoring tongue protrusions, retrusions and swallows. Reduction began at the 0.04 mg/kg dose. At 4.8 mg/kg there was total suppression of events. At 20 mg/kg, suppression lasted for 1 h. Notably clozapine doses causing total suppression of events in our model were much lower than those usually reported to alter dopamine turnover.
authors.affiliation: Department of Psychiatry, College of Medicine, University of South Alabama, Mobile 36617.
authors.forename: L A
authors.initials: LA
authors.lastname: Marco
authors.forename: R S
authors.initials: RS
authors.lastname: Joshi
authors.forename: T E
authors.initials: TE
authors.lastname: Brigham
authors.forename: L D
authors.initials: LD
authors.lastname: Aldes
authors.forename: R B
authors.initials: RB
authors.lastname: Chronister
mesh_terms: D000818:Animals; D003024:Clozapine / Q000494:pharmacology*; D003679:Deglutition / Q000187:drug effects*; D003984:Dibenzazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007649:Ketamine / Q000494:pharmacology*; D010614:Pharynx / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014059:Tongue / Q000187:drug effects / Q000502:physiology*
chemical_list: D003984:Dibenzazepines; D007649:Ketamine; D003024:Clozapine