Effect of pyritinol on the dopaminergic system and behavioural outcome in an animal model of mild chronic postnatal hypoxia.
Rats after mild chronic postnatal hypoxia always show late sequelae of behaviour and long-term alterations of neurotransmitter release from striatal slices. It was to test preventive or therapeutic actions of drugs using the model of mild chronic postnatal hypoxia of the rat. Pyritinol prevented the learning deficit due to hypoxia and decreases the potassium stimulated DA release from striatal slices. The experiments underline the high plasticity of the CNS during the neonatal period and stress the necessity of early therapy of perinatal brain damage.
Lun
A
A
Institute of Pathological and Clinical Biochemistry, Charite Hospital, Humboldt University, Berlin, GDR.
Gruetzmann
H
H
Wustmann
C
C
Szuesz
L
L
Dominick
B
B
Horvath
G
G
Fischer
H D
HD
Nagy
I
I
Gross
J
J
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002908:Chronic Disease; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D000860:Hypoxia / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D066298:In Vitro Techniques; D008297:Male; D011725:Pyridines / Q000494:pharmacology*; D011746:Pyrithioxin / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D015430:Weight Gain
D011725:Pyridines; D011746:Pyrithioxin; D004298:Dopamine