[New approaches to the study of thrombocyte aggregation in patients with dilated cardiomyopathy].
A degree of platelet aggregation in patients with dilatation cardiomyopathy (DCMP) with different stages of heart failure (HF) was evaluated with the help of a highly sensitive aggregometer developed in the All-Union Cardiological Research Center AMS USSR. The main advantage of this modification was a possibility to study platelet aggregation in response to small doses of an inductor (e.g. less than 0.2 microM of ADP) that could not be done using routine methods. A significant rise of a degree of platelet aggregation was revealed in patients with 0-I,IIA stages of DCMP and IIB-III stages of HF in response to 0.1 microM of ADP. Platelet aggregation was enhanced with an increase in a HF stage. The addition of a higher concentration of ADP (0.2-0.5 microM) and the platelet aggregation factor (5 and 25 nM) revealed no rise of platelet aggregation in patients with 0-I stages of DCMP and IIA stage of HF. Only in patients with stages IIB-III of HF was a platelet aggregation index significantly raised in response to 0.2 and 0.5 microM of ADP but to a much lesser degree than in the addition of 0.1 microM of ADP.
Skvortsov
A A
AA
Gabbasov
Z A
ZA
Popov
E G
EG
Naumov
V G
VG
Okur
F M
FM
D000244:Adenosine Diphosphate / Q000008:administration & dosage / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000097:blood*; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D010972:Platelet Activating Factor / Q000008:administration & dosage / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010979:Platelet Function Tests / Q000379:methods; D013268:Stimulation, Chemical
D003470:Culture Media; D010972:Platelet Activating Factor; D000244:Adenosine Diphosphate
Novye podkhody v izuchenii agregatsii trombotsitov u bol'nykh s dilatatsionnoĭ kardiomiopatieĭ.