Pharmacokinetics of amoxycillin/clavulanic acid in serum and ascitic fluid in cirrhotic patients.
A combination of amoxycillin and clavulanic acid (Augmentin) might be useful for first-line treatment of spontaneous bacterial peritonitis in patients with cirrhosis. We have studied the pharmacokinetics of amoxycillin/clavulanic acid in serum and ascitic fluid of six cirrhotic patients. A total of 66 simultaneous serum and ascitic samples were analysed. Following iv injection of 1 g amoxycillin plus 0.2 g clavulanic acid, the ascites to serum AUC ratio was 1.38 for amoxycillin and 1.01 for clavulanic acid, indicating a good distribution of these drugs into the ascitic fluid. In this study, experimental data were fitted to a three compartment body model which revealed that the prolonged serum half-lives of amoxycillin (274 min) and clavulanic acid (200 min) were probably due to the slow return from the ascitic compartment.
Grange
J D
JD
Service d'hépatologie et unité de Pharmacologie Clinique, Hôpital Tenon, Paris, France.
Gouyette
A
A
Gutmann
L
L
Amiot
X
X
Kitzis
M D
MD
Islam
S
S
Acar
J F
JF
Jaillon
P
P
D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000097:blood / Q000493:pharmacokinetics*; D001202:Ascitic Fluid / Q000378:metabolism*; D001681:Biological Assay; D002969:Clavulanic Acids / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological
D002969:Clavulanic Acids; D000658:Amoxicillin