title: Teratological evaluation of Juniperus sabina essential oil in mice.
abstract: Juniperus sabina essential oil was evaluated for its fetotoxic potential on mice. Pregnant dams were injected s.c. (15-45 or 135 mg essential oil/kg body weight) on days 6 to 15 of gestation. They were killed and the uterine contents were examined on day 19 of pregnancy. The fetuses were removed for examination. The dams of the two higher treated groups showed a significant weight loss as compared to controls. An hepatotoxicity was observed among females that resorbed their whole litter, thus indicating a greater susceptibility towards Juniperus sabina essential oil during pregnancy. The essential oil induced, in the three treated groups, an embryotoxicity as manifested by a statistically significant increase in the number of affected litters; but no fetotoxicity.
authors.forename: N
authors.initials: N
authors.lastname: Pages
authors.forename: G
authors.initials: G
authors.lastname: Fournier
authors.forename: G
authors.initials: G
authors.lastname: Chamorro
authors.forename: M
authors.initials: M
authors.lastname: Salazar
authors.forename: M
authors.initials: M
authors.lastname: Paris
authors.forename: C
authors.initials: C
authors.lastname: Boudene
mesh_terms: D000818:Animals; D005260:Female; D051379:Mice; D009822:Oils, Volatile / Q000633:toxicity*; D010938:Plant Oils / Q000633:toxicity*; D013723:Teratogens; D014197:Trees / Q000032:analysis*
chemical_list: D009822:Oils, Volatile; D010938:Plant Oils; D013723:Teratogens