title: Elimination and haemodynamic effects of nitrendipine in patients with chronic renal failure.
abstract: In sixteen patients with arterial hypertension and differing degrees of renal function the pharmacokinetics and haemodynamic effects of nitrendipine have been studied after treatment for 7 days. The AUC (0-24) and the elimination half-life of nitrendipine were significantly increased; the AUC (0-24) in patients with renal failure (median creatinine clearance 27.1 ml x min-1) was 196 ng x ml-1 x h compared to 97.8 ng x ml-1 x h in control subjects (median creatinine clearance 94.4 ml x min-1). The corresponding elimination half-lives were 13.5 h in renal failure and 4.4 h in the controls. The haemodynamic effects of nitrendipine were not enhanced in the patients.
authors.affiliation: I. Medizinische Klinik, Christian-Albrechts-Universität, Kiel, FederaRepublic of Germany.
authors.forename: T
authors.initials: T
authors.lastname: Ankermann
authors.forename: U
authors.initials: U
authors.lastname: Osterkamp
authors.forename: S R
authors.initials: SR
authors.lastname: Santos
authors.forename: W
authors.initials: W
authors.lastname: Kirch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D009568:Nitrendipine