A pharmacokinetic model for intraperitoneal administration of drugs: application to teniposide in humans.
A pharmacokinetic study of teniposide after ip administration with a 4-h dwell time was performed in patients suffering from abdominal malignant ascites. A three-compartment open model was developed to fit together the data obtained in plasma and peritoneum. The pharmacokinetic parameters obtained by the model agreed with those obtained by model-independent analysis, and the fitting correctly depicted the plasma and peritoneal concentration decays. According to the results, such a model could be applied to ip administration of anticancerous drugs.
Canal
P
P
Départment de Biologie Clinique et d'Oncologie Médicale Centre Claudius, Toulouse, France.
Plusquellec
Y
Y
Chatelut
E
E
Bugat
R
R
De Biasi
J
J
Houin
G
G
D000293:Adolescent; D006207:Half-Life; D006801:Humans; D007274:Injections, Intraperitoneal; D008954:Models, Biological; D011034:Podophyllotoxin / Q000031:analogs & derivatives*; D013713:Teniposide / Q000008:administration & dosage / Q000493:pharmacokinetics*
D013713:Teniposide; D011034:Podophyllotoxin