Plasma free dopamine in human hypertension.
The concentration of plasma free dopamine (PDA) is said to be much lower than that of other catecholamines and its physiological significance remains unclear. Our recent studies using a newly developed radioenzymatic method disclosed the fairly distinctive features of PDA in patients with various types of hypertension. PDA was also confirmed as a variable responsive to postural change, dietary sodium loading and dopamine receptor antagonist. The results suggest that PDA could be a sensitive marker to represent the peripheral dopaminergic function, which might play an inherent role as a physiological regulator responsible for the cardiovascular and endocrine system.
Miura
Y
Y
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Takahashi
M
M
Sano
N
N
Ohzeki
T
T
Meguro
Y
Y
Sugawara
T
T
Noshiro
T
T
Watanabe
H
H
Shimizu
K
K
Abe
K
K
D004032:Diet; D004298:Dopamine / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008722:Methods; D008787:Metoclopramide / Q000494:pharmacology; D012016:Reference Values; D012964:Sodium / Q000494:pharmacology
D012964:Sodium; D008787:Metoclopramide; D004298:Dopamine