Evaluation of cytotoxic and antitumor effects of a tetravalent analog of carboplatin.
The cytostatic and cytocidal effects of a newly synthesized tetravalent platinum drug (CBDCA-ox) on two experimental ascites tumors as well as on normal tissues of the mouse were investigated. It was found that CBDCA-ox exhibited only negligible acute toxicity in comparison with its reduced analog. Also hemotoxicity of this tetravalent drug was markedly lower than that of CBDCA. The comparison of antitumor activity of CBDCA and CBDCA-ox tested against LS/BL lymphosarcoma and EAT tumor cells strongly supports the view that CBDCA-ox deserves further preclinical testing.
Jurásková
V
V
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
Brabec
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V
D000818:Animals; D016190:Carboplatin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007928:Lethal Dose 50; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D014407:Tumor Cells, Cultured / Q000187:drug effects
C066896:diamminecyclobutane-1,1-dicarboxylatodihydroxyplatinum(IV); D016190:Carboplatin