title: Synthesis of new annellated flavonoid derivatives possessing spasmolytic activity--VII.
abstract: 7,8-Dihydroxyflavone reacts with ethyl 2,3-dibromopropanoate to form the new, annellated, 1,4-benzodioxanes 1 containing a flavone structural unit. The regioisomers 1a and 1b thus obtained were separated and 1a was converted to the amides 2a-2f. The constitutions of 1 and 2 were elucidated by 500 MHz 1H-NMR spectroscopy. In the spasmolysis test, 2e showed significant antagonistic effect towards the agonists acetylcholine, barium chloride, and histamine.
authors.forename: R
authors.initials: R
authors.lastname: Ertan
authors.forename: H
authors.initials: H
authors.lastname: Göker
authors.forename: M
authors.initials: M
authors.lastname: Ertan
authors.forename: U
authors.initials: U
authors.lastname: Pindur
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology; D010276:Parasympatholytics / Q000138:chemical synthesis*
chemical_list: D005419:Flavonoids; D010276:Parasympatholytics