title: Recovery of benthiocarb-inhibited AChE in fish brain: an in vitro study.
abstract: The effects in vivo and in vitro of benthiocarb, an organocarbamate, on acetylcholinesterase (AChE) activity and its recovery in vitro in the brain of the freshwater fish Sarotherodon mossambicus have been studied. Findings revealed that the specific activity of AChE was inhibited both in vivo and in vitro in a concentration-dependent manner. Of the different modulators tested, dexamethasone (0.72 mg), prednisolone (0.74 mg), testosterone (0.9 mg), and ADP (9.5 mg) were found to neutralize the inhibitory effect (IC50 = 0.30 microM) of benthiocarb on AChE.
authors.affiliation: Department of Zoology, Sri Venkateswara University, Tirupati, India.
authors.forename: P R
authors.initials: PR
authors.lastname: Babu
authors.forename: G R
authors.initials: GR
authors.lastname: Reddy
authors.forename: G R
authors.initials: GR
authors.lastname: Babu
authors.forename: C S
authors.initials: CS
authors.lastname: Chetty
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002800:Cholinesterase Inhibitors; D005399:Fishes; D066298:In Vitro Techniques; D013859:Thiocarbamates / Q000633:toxicity*; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D002800:Cholinesterase Inhibitors; D013859:Thiocarbamates; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; C037925:benthiocarb; D000110:Acetylcholinesterase