[Macrophage transformation of mononuclear cells following primary and secondary experimental immunization with measles vaccine].
Cell-mediated and humoral immune response was studied in guinea pigs receiving two immunizations with live measles vaccine l-16 in doses of 1000 TCD50/0.5 ml at an interval of 45 days. The results of this study showed that the maximum level of the macrophagal transformation of mononuclears and the most intensive synthesis of antimeasles antibodies were observed on day 10 after booster immunization. The intensification of cell-mediated and humoral immune response was found to depend on the initial immunological background. The animals having had high values of cell-mediated response before booster immunization showed a decrease in these values, while an increase in antibody titers in such animals was transitory.
Zakharova
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TR
Bolotovskiĭ
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VM
Titova
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D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002478:Cells, Cultured; D006168:Guinea Pigs; D007111:Immunity, Cellular; D007114:Immunization; D007117:Immunization, Secondary; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008262:Macrophage Activation; D008458:Measles Vaccine / Q000276:immunology*; D008459:Measles virus / Q000276:immunology; D013997:Time Factors
D000914:Antibodies, Viral; D008458:Measles Vaccine
Makrofagal'naia transformatsiia mononuklearov posle pervichnoĭ i vtorichnoĭ immunizatsii korevoĭ vaktsinoĭ v éksperimente.