title: Allergic aspergillosis: a newly recognized form of sinusitis in the pediatric population.
abstract: In 1983, Katzenstein, et al. first described a form of noninvasive sinusitis in adults, which was histologically identical to allergic bronchopulmonary aspergillosis, with mucin-containing eosinophils, Charcot-Leyden crystals, and fungal elements resembling Aspergillus species. The authors have treated six pediatric patients ages 8 to 16 who had findings typical of allergic Aspergillus sinusitis. All patients presented with nasal polyposis and progressive facial deformity. All patients had computed tomography findings of diffuse expansile sinus disease and four patients had evidence of bony erosion, raising the suspicion of malignancy. At surgery, all were found to have multiple sinuses densely packed with greenish-black inspissated mucin. Therapy consisted of wide surgical drainage with careful follow-up and nasal steroids.
authors.affiliation: Department of Otolaryngology, University of Texas Southwestern Medical Center, Dallas 75235-9035.
authors.forename: S C
authors.initials: SC
authors.lastname: Manning
authors.forename: F
authors.initials: F
authors.lastname: Vuitch
authors.forename: A G
authors.initials: AG
authors.lastname: Weinberg
authors.forename: O E
authors.initials: OE
authors.lastname: Brown
mesh_terms: D000293:Adolescent; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009077:Mucins; D009298:Nasal Polyps / Q000473:pathology; D012852:Sinusitis / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D009077:Mucins