Phaeochromocytomas secreting adrenaline but not noradrenaline do not cause hypertension and require precise adrenaline measurement for diagnosis.
1. Urinary noradrenaline (NA) and adrenaline (ADR) determinations are a more sensitive index than plasma measurements for the diagnosis of phaeochromocytoma (phaeo). 2. Even though urinary NA excretion serve as a sufficient single diagnostic test for the majority of phaeos, it is necessary to measure urinary ADR excretion if ADR-only secreting phaeos are not to be missed, particularly in patients with multiple endocrine neoplasia (MEN) syndrome. 3. The clonidine suppression test confirmed all tumour diagnoses, and in this series was not responsible for any false negative or false positive results.
Bachmann
A W
AW
Endocrine-Hypertension Research Unit, Greenslopes Hospital, Brisbane, Queensland, Australia.
Hawkins
P G
PG
Gordon
R D
RD
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D003000:Clonidine; D004837:Epinephrine / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism*; D010673:Pheochromocytoma / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism
D003000:Clonidine; D009638:Norepinephrine; D004837:Epinephrine