Significance of prostaglandin E2 in acute necrotising pancreatitis in rats.
Acute necrotising pancreatitis in rats was induced by injecting 5% sodium taurocholate into the pancreatic duct. Prostaglandin E2 (100 micrograms/kg subcutaneously twice) decreased the mortality rate from 100% to 60% (NS). When treatment with prostaglandin E2 was combined with simultaneous administration of either dazmegrel (UK 38,485, 50 mg/kg bodyweight) or Sibelium (Flunarizine R 14,950, 0.2 mg/kg body weight) a significant decrease in the mortality rate (p less than 0.05) was recorded. Dazmegrel is a selective thromboxane A2 synthetase inhibitor and prevents the formation of thromboxane A2. Flunarizine (a calcium entry blocker) decreases thromboxane A2 formation and also inhibits the effects of raised thromboxane A2 concentrations. As plasma thromboxane B2 (the stable metabolite of thromboxane A2) concentrations increase and the plasma prostaglandin E2 concentrations decrease in acute necrotising pancreatitis in rats, the results of the present study indicate that these prostaglandins play a role in the pathophysiology of the disease. It is suggested that restoration of the balance in prostanoid concentrations will have a beneficial effect on the course of acute necrotising pancreatitis.
van Ooijen
B
B
Department of Experimental Surgery, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands.
Kort
W J
WJ
Tinga
C J
CJ
Wilson
J H
JH
Westbroek
D L
DL
D000208:Acute Disease; D000818:Animals; D015232:Dinoprostone / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005444:Flunarizine / Q000627:therapeutic use; D007093:Imidazoles / Q000627:therapeutic use; D008297:Male; D009336:Necrosis; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors
D007093:Imidazoles; C039242:dazmegrel; D013930:Thromboxane-A Synthase; D015232:Dinoprostone; D005444:Flunarizine