title: Use of extracts of Picralima nitida bark in the treatment of experimental trypanosomiasis: a preliminary study.
abstract: The effect of a boiling water extract of Picralima nitida bark against trypanosomes (T. brucei) in rats was compared with that of diminazene aceturate at 8 mg/kg i.p. Results showed that the extract had a definite trypanocidal effect which was statistically comparable to that of diminazene aceturate. Further work is needed to identify the active pharmacological agent and to standardise the usage of the agent in practice.
authors.affiliation: Department of Veterinary Medicine, University of Nigeria, Nsukka.
authors.forename: L O
authors.initials: LO
authors.lastname: Wosu
authors.forename: C C
authors.initials: CC
authors.lastname: Ibe
mesh_terms: D000818:Animals; D004133:Diminazene / Q000031:analogs & derivatives / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005260:Female; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D014344:Trypanocidal Agents / Q000627:therapeutic use; D014346:Trypanosoma brucei brucei; D014353:Trypanosomiasis, African / Q000188:drug therapy* / Q000469:parasitology
chemical_list: D010936:Plant Extracts; D014344:Trypanocidal Agents; C003915:diminazene aceturate; D004133:Diminazene