title: Rapid decrease of the peripheral deiodination of thyroxine in malabsorption syndrome in artificially inoculated broilers.
abstract: Thyroid function of broilers inoculated with the intestinal homogenate from birds from a field case of malabsorption syndrome was investigated during the first 2 days postinoculation. In one experiment, different amounts of the inoculum were applied to see if there exists a dose-response relationship. As early as 3 hours after inoculation, there was a significant drop in the serum level of triiodothyronine and in the activity of the liver 5'-deiodinase (type I). Type II deiodinase activity was less impaired. A minimum of 0.3 ml of inoculum was effective, whereas 0.05 ml of the same homogenate elicited a significant (P less than 0.01) drop in liver deiodinase activity. These findings underline the importance of thyroid impairment in the pathogenesis of malabsorption syndrome.
authors.affiliation: Department of Physiology, University of Veterinary Science, Budapest, Hungary.
authors.forename: P
authors.initials: P
authors.lastname: Rudas
authors.forename: G
authors.initials: G
authors.lastname: Sályi
authors.forename: J
authors.initials: J
authors.lastname: Szabó
mesh_terms: D000818:Animals; D002645:Chickens / Q000378:metabolism*; D007453:Iodide Peroxidase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008286:Malabsorption Syndromes / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary*; D011201:Poultry Diseases / Q000378:metabolism* / Q000503:physiopathology; D013961:Thyroid Gland / Q000503:physiopathology*; D013974:Thyroxine / Q000097:blood / Q000378:metabolism*; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D007453:Iodide Peroxidase; D013974:Thyroxine