Inhibition of ifosfamide-induced urotoxicity by disulfiram in mice.
The effect of disulfiram on the urotoxicity induced by ifosfamide was studied in mice. Ifosfamide administered intraperitoneally to mice caused a dose-related increase in bladder weight within 48 hr of treatment. Disulfiram prevented ifosfamide-induced bladder damage when administered orally within 1 hr of ifosfamide treatment. The results indicate that disulfiram is an effective protective agent against bladder damage caused by ifosfamide treatment.
Ishikawa
M
M
Institute of Cancer Research, Tohoku College of Pharmacy, Sendai, Japan.
Takayanagi
Y
Y
Sasaki
K
K
D000284:Administration, Oral; D000818:Animals; D004221:Disulfiram / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D007069:Ifosfamide / Q000009:adverse effects*; D008297:Male; D051379:Mice; D001743:Urinary Bladder / Q000187:drug effects* / Q000473:pathology; D001745:Urinary Bladder Diseases / Q000139:chemically induced / Q000517:prevention & control*
D004221:Disulfiram; D007069:Ifosfamide