Altered levels of microtubule proteins in brains of Alzheimer's disease patients.
The amount of microtubule protein present in the total soluble protein from brains of Alzheimer's disease patients and from brains of non-Alzheimer age-matched controls, were determined by radioimmunoassay. No differences were found in the amount of tubulin or microtubule-associated protein MAP2 present in either group. However, the amount of tau protein or MAP1 from the brains of Alzheimer's disease patients was about half of that present in their control counterparts.
Nieto
A
A
Centro de Biología Molecular (CSIC-UAM), Universidad Autónoma, Madrid, Spain.
Montejo de Garcini
E
E
Avila
J
J
D000544:Alzheimer Disease / Q000378:metabolism*; D001923:Brain Chemistry; D004258:DNA Polymerase III; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000032:analysis*; D008970:Molecular Weight; D011863:Radioimmunoassay; D014157:Transcription Factors / Q000032:analysis; D014404:Tubulin / Q000032:analysis
D008869:Microtubule-Associated Proteins; D014157:Transcription Factors; D014404:Tubulin; C041273:transcription factor tau; D004258:DNA Polymerase III