[Effect of naloxone on blood microcirculatory changes in anaphylactic shock].
During the experiment conducted upon 85 guinea-pigs it has been found that the injection of naloxone at the dose of 0.5 g/kg half an hour before the reproduction of anaphylactic shock (AS) by the use of horse serum increases the number of cases of the retarded development of pathological reaction and survival of the animals. Except for the quantitative differences mentioned any peculiarities characterizing the effect of naloxone were not found. As to the morphological differences of variants in the course of AS they are distinctly defined only at the analysis of film preparations of the intestinal mesentery. The typical AS becomes apparent by haemorrhages, by dilatation of all the vessels of blood circulation and by forming of erythrocytic aggregates in them. At the retarded development of AS a spasm of precapillaries is observed. After convalescence of the animals the aggregates of erythrocytes can be revealed only in venules. Studying the animals recovered after AS one can find that for a long time these animals had the erythrocytic aggregates in the clearances of venules, as well as the signs of new formation of the capillaries.
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D000707:Anaphylaxis / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D007114:Immunization / Q000379:methods; D008638:Mesenteric Arteries / Q000187:drug effects / Q000473:pathology; D008642:Mesenteric Veins / Q000187:drug effects / Q000473:pathology; D008833:Microcirculation / Q000187:drug effects / Q000473:pathology; D009270:Naloxone / Q000627:therapeutic use*; D013997:Time Factors
D009270:Naloxone
Vliianie naloksona na izmeneniia gemomikrotsirkuliatsii pri anafilakticheskom shoke.