title: [Monoiodoacetic acid-induced arthropathy of the rabbit knee--a contribution to the pathogenesis of arthrosis].
abstract: A chemically-induced joint degeneration was produced by an one-time intraarticular injection of the glycolysis inhibitor monoiodic acetate into the rabbit knee joint (32 joints of 16 rabbits + 4 control animals). The investigation is founded on Kalbhen's animal model of osteoarthrosis and on Salter's and Moskowitz' experiments. Histomorphological examinations were done in intervals of 1 day to 12 weeks. The results raise several open questions in experimental as well as clinical aspects. On that account these results were discussed pathogenetically in the view of the own pathophysiological and biocybernetical conception of osteoarthrosis development.
authors.forename: G
authors.initials: G
authors.lastname: Regling
authors.forename: P
authors.initials: P
authors.lastname: Buntrock
authors.forename: W
authors.initials: W
authors.lastname: Geiss
authors.forename: K
authors.initials: K
authors.lastname: Lindenhayn
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006019:Glycolysis / Q000187:drug effects*; D007270:Injections, Intra-Articular; D007461:Iodoacetates / Q000494:pharmacology*; D019807:Iodoacetic Acid; D007719:Knee Joint / Q000187:drug effects*; D010003:Osteoarthritis / Q000139:chemically induced*; D011817:Rabbits
chemical_list: D007461:Iodoacetates; D019807:Iodoacetic Acid
vernacular_title: Die Monojodazetat-induzierte Arthropathie am Kaninchenknie--Ein Beitrag zur Pathogenese der Arthrose.