Factor VII coagulant activity is strongly associated with the plasma concentration of large lipoprotein particles in middle-aged men.
A community survey of factor VII coagulant activity (VIIc) and the lipoprotein profile in non-fasting plasma of middle-aged men in NW London was undertaken to search for the determinants of VIIc in the general community. The data demonstrates that associations between VIIc and the plasma concentrations of cholesterol and of triglycerides previously shown in the general population can be explained by the strong and positive associations between VIIc and the large lipoprotein particles, chylomicrons, VLDL and IDL. Consistent with the possibility that the concentration of large lipoproteins determines the in vivo reactivity of factor VII, the association between VIIc and the ratio of lipid in the d greater than 1.019 fraction to the total plasma lipid was also highly significant but negative. The observed correlations between VIIc and lipoproteins smaller than VLDL may be the product of the interrelations that exist between the lipoprotein fractions in plasma. However, the associations between VIIc and the chylomicron lipid concentrations are especially strong when allowance is made for the considerable bias towards zero in the observed correlation, due to large within-person variance in chylomicron concentration.
Mitropoulos
K A
KA
MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, U.K.
Miller
G J
GJ
Reeves
B E
BE
Wilkes
H C
HC
Cruickshank
J K
JK
D000367:Age Factors; D001777:Blood Coagulation; D002914:Chylomicrons / Q000097:blood; D005167:Factor VII / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged
D002914:Chylomicrons; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D005167:Factor VII