Biochemical HLA typing: a population study in 112 Caucasians.
In order to define frequencies and associations of biochemically defined HLA-A and -B specificities and their variants and subtypes in a Caucasian population, biochemical HLA typing was performed in a panel of 112 Austrians. Already known rare variants of HLA-A2, A3, A30, Aw33 and B39 and the more frequent subtypes of HLA-B27, B35, B44 and, in addition, a so far unknown variant of HLA-B18 were present in the panel. Family segregation analyses of the biochemically defined HLA class I variants revealed that they could be found only in certain rare haplotypes, most of them in high linkage disequilibrium. The basic variant of HLA-A30, for example, obviously occurred only in the HLA-A30, B49, Cw7 haplotype, similar to the Aw33 acidic variant, which was exclusively found in the Aw33, Bw58, Cw3 haplotype. None of the biochemical variants was found in frequent common haplotypes.
Hajek-Rosenmayr
A
A
Institute for Blood Group Serology, University of Vienna, Austria.
Jungl
L
L
Oppolzer
E
E
Stammler
M
M
Gruber
G
G
Kirnbauer
M
M
D001671:Biochemistry / Q000379:methods*; D014644:Genetic Variation; D015234:HLA-A Antigens / Q000032:analysis / Q000235:genetics; D015235:HLA-B Antigens / Q000032:analysis / Q000235:genetics; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D013223:Statistics as Topic; D044465:White People
D015234:HLA-A Antigens; D015235:HLA-B Antigens