The effects of various peptides on the isolated pulmonary artery.
Helical strips of pulmonary arteries from rabbits were tested for their responses to the following peptides: neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), substance P (SP), cholecystokinin-octapeptide (CCK), somatostatin (SS), bombesin, neurotensin and gastrin. SP, in the absence of active base-tension, and NPY both induced concentration-dependent contractions, while VIP and SP, in the presence of active base-tone, and CCK induced relaxation. The pD2 (-log ED50) was in the order of NPY greater than SP and SP greater than CCK greater than VIP. SS, bombesin, NT and gastrin had no effect. These findings suggest peptidergic involvement in the vessels.
Obara
H
H
Department of Anesthesiology, Kobe University School of Medicine, Japan.
Kusunoki
M
M
Mori
M
M
Mikawa
K
K
Iwai
S
S
D000818:Animals; D015237:Dinoprost / Q000494:pharmacology; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009479:Neuropeptides / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D014661:Vasoconstriction / Q000187:drug effects*
D005768:Gastrointestinal Hormones; D009479:Neuropeptides; D010455:Peptides; D015237:Dinoprost