Spontaneous disseminated panarteritis in laboratory beagle dogs in a toxicity study: a possible genetic predilection.
Disseminated panarteritis was found in 16 (9 males and 7 females) of 49 laboratory beagle dogs (25 males and 24 females) from one breeding kennel. The dogs had been used in a 6-month oral toxicity study. Panarteritis was not associated with clinical or gross abnormalities. The incidence was similar in the control and test article-treated groups. Mainly medium-sized arteries throughout the body, particularly intercostal arteries (at their aortic origin), and coronary, epididymal and thymic vessels were affected. Chronic mononuclear-cell periarteritis was the predominant feature. Mixed cellular inflammation of the wall, proliferation or degeneration of muscle cells, focal "fibrinoid" material in the tunica media, fragmented internal elastic lamina and intimal thickening associated with myointimal cellular proliferation also occurred. These histologic changes are compatible with those of immune arteritis. Round worm intestinal infestation and granulomas of visceral larva migrans were common in several organs. Statistical analyses suggested that the pedigree of dogs is related to panarteritis, but the presence or absence of parasitization alone is not. The possible roles of genetic predilection and/or parasites in the pathogenesis are discussed. This panarteritis is spontaneous and may complicate the interpretation of lesions in toxicity studies.
Ruben
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Z
Research & Development, G. D. Searle & Co., Skokie, Illinois 60077.
Deslex
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P
Nash
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Redmond
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NI
Poncet
M
M
Dodd
D C
DC
D000818:Animals; D001167:Arteritis / Q000235:genetics / Q000503:physiopathology* / Q000662:veterinary; D003327:Coronary Disease / Q000473:pathology; D004283:Dog Diseases / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D004285:Dogs; D004822:Epididymis / Q000473:pathology / Q000503:physiopathology; D005260:Female; D007815:Larva Migrans / Q000469:parasitology / Q000503:physiopathology; D008297:Male; D013737:Testis / Q000473:pathology