An increase of collagen biosynthesis in livers of rats submitted to chronic intoxication with ethanol.
It was found that chronic intoxication of rats with ethanol results in a distinct, progressive increase of 5(3)H-proline incorporation into collagen synthesized by liver. At the same time biosynthesis of other proline-containing proteins in rat liver slightly decreases. These effects precede the morphological symptoms of liver damage induced by ethanol.
Bańkowski
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E
Department of Biochemistry, Academy of Medicine, Białystok, Poland.
Pawlicka
E
E
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D006909:Hydroxyproline / Q000032:analysis; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013997:Time Factors
D003094:Collagen; D006909:Hydroxyproline