Experimental selenium toxicity in guinea pigs: biochemical studies.
Biochemical studies were conducted in experimentally induced selenium toxicity in recently weaned guinea pigs. A significant drop in blood glucose level, in comparison to controls, was observed in animals fed selenium-enriched barley (organic form) as well as those fed ordinary barley mixed with sodium selenite (inorganic form). Estimation of total serum proteins also revealed a significant drop in both these groups. SGOT (EC 2.6.1.1) activity was comparatively lower but no significant alteration was noticed in SGPT (EC 2.6.1.2). The erythrocytic glutathione peroxidase activity was significantly increased in inorganic selenosis followed by that in organic one, in comparison to controls. All these alterations were of mild degree in guinea pigs which were given sodium arsenite (10 ppm) along with sodium selenite (30 ppm) in the feed.
Das
P M
PM
Department of Veterinary Pathology, Haryana Agricultural University, Hissar, India.
Sadana
J R
JR
Gupta
R K
RK
Kumar
K
K
D000818:Animals; D001151:Arsenic / Q000627:therapeutic use; D018053:Arsenites; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D005979:Glutathione Peroxidase / Q000097:blood; D006168:Guinea Pigs; D001467:Hordeum; D020887:Selenious Acid; D012643:Selenium / Q000378:metabolism / Q000627:therapeutic use / Q000633:toxicity*; D017670:Sodium Compounds
D018053:Arsenites; D001786:Blood Glucose; D001798:Blood Proteins; D017670:Sodium Compounds; C017947:sodium arsenite; D005979:Glutathione Peroxidase; D020887:Selenious Acid; D012643:Selenium; D001151:Arsenic