title: Prevention of the formation of arterial thrombi using different antiplatelet drugs: experimental study in dogs.
abstract: We have induced the formation of arterial thrombosis in dogs by means of an intima lesion produced by continuous current. The platelets were labeled with 111-In-oxine. Groups of 7 mongrel dogs received treatment for 7 days prior to the trial: Group I, control; Group II, 5 mg/kg body weight/day acetylsalicylic acid; Group III, 20 mg/kg body wt/day acetylsalicylic acid; Group IV, 15 mg/kg body wt/day triflusal + 5 mg/kg body wt/day dipyridamole; Group V, 15 mg/kg body wt/day triflusal; and Group VI, 5 mg/kg body wt/day acetylsalicylic acid + 5 mg/kg body wt/day dipyridamole. The only effective treatment for arterial thrombosis prevention was that employed in Group II (p less than 0.05).
authors.affiliation: Servicio de Cirugía Experimental, Clínica Puerta de Hierro, Madrid, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Escudero-Vela
authors.forename: L
authors.initials: L
authors.lastname: Alvarez
authors.forename: V
authors.initials: V
authors.lastname: Rodríguez
authors.forename: J H
authors.initials: JH
authors.lastname: del Moral
authors.forename: I
authors.initials: I
authors.lastname: Millán
authors.forename: J L
authors.initials: JL
authors.lastname: Castillo-Olivares
mesh_terms: D000818:Animals; D001241:Aspirin / Q000097:blood / Q000627:therapeutic use; D004176:Dipyridamole / Q000627:therapeutic use; D004285:Dogs; D007205:Indium Radioisotopes; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D012459:Salicylates / Q000627:therapeutic use; D012588:Scintillation Counting; D013927:Thrombosis / Q000517:prevention & control*
chemical_list: D007205:Indium Radioisotopes; D010975:Platelet Aggregation Inhibitors; D012459:Salicylates; C016167:triflusal; D004176:Dipyridamole; D001241:Aspirin