Pre-clinical studies on boron neutron capture therapy.
The present report provides an overview of the multidisciplinary research effort on BNCT that currently is in progress at The Ohio State University. Areas under investigation include the preparation of boron containing monoclonal antibodies, the synthesis of boron containing derivatives of promazines and phathalocyanines, the development of a rat model for the treatment of glioblastoma by means of BNCT, the design of an accelerator-based neutron irradiation facility, and 10B concentration measurements using alpha track autoradiographic methods. Progress in each of these areas is described and the direction of future research is indicated.
Barth
R F
RF
Ohio State University, Columbus 43210.
Soloway
A H
AH
Alam
F
F
Clendenon
N R
NR
Blue
T E
TE
Mafune
N
N
Goodman
J H
JH
Gordon
W
W
Bapat
B
B
Adams
D M
DM
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001895:Boron / Q000627:therapeutic use*; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D005910:Glioma / Q000532:radiotherapy*; D011878:Radiotherapy / Q000295:instrumentation / Q000379:methods*; D051381:Rats; D014407:Tumor Cells, Cultured / Q000528:radiation effects
D000911:Antibodies, Monoclonal; D001895:Boron