[Changes in the growth characteristics of mouse and rat fibroblasts during tumor progression].
Changes in growth characteristics (the growth in a mat of normal cells, contact inhibition of division, growth-substrate dependence, dependence on the serum growth factors) and tumourigenicity were compared in 6 cells lines of mice and rats during their in vitro and in vivo long passages. All these factors progressed independently of a tumourigenicity increase, i.e. they obeyed the Fould principle. The trait responsible for the cell capacity to proliferate on a layer of normal cells proved to be the most correct one relative to tumourigenicity prediction.
Lavrovskiĭ
V A
VA
Dobrunova
E P
EP
Shcherbakov
A E
AE
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000473:pathology*; D002478:Cells, Cultured; D003260:Contact Inhibition / Q000187:drug effects; D003470:Culture Media; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology*; D006133:Growth Substances / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains
D003470:Culture Media; D006133:Growth Substances
Izmenenie rostovykh kharakteristik fibroblastov mysheĭ i krys v protsesse opukholevoĭ progressii.