title: [Echocardiography with angiotensin administration in the diagnosis of adriamycin-induced cardiomyopathy].
abstract: Noninvasive assessment of early cardiotoxicity of doxorubicin is still a problem of clinical concern. We studied whether echocardiography during afterload stress induced by angiotensin II (1,000-3,000 ng/min) allows earlier detection of left ventricular impairment than echo at rest. We compared 30 normals (N) to 30 patients with carcinoma, who had received doxorubicin at a cumulative dose of at least 360 mg/sqm. At rest echocardiograms of patients were either normal (P1; n = 24) or abnormal (P2; n = 6; fractional shortening less than 28%, distance of mitral E-point to septum greater than 7 mm). Best parameter for separation of P1 vs N was the slope K of the regression line of the relation between endsystolic diameter and systolic blood pressure (cuff-method). 38% of P1 and 100% of P2 had K-values below the range of N (less than 4.7 mm Hg/mm). Four of five patients with reduced ejection fraction assessed by scintigraphy (less than 55%) after continued therapy with doxorubicin have had, in previous echocardiographic studies, normal resting parameters but abnormal K-values. We conclude that afterload-stress increases the sensitivity of echocardiography in detecting cardiotoxicity due to doxorubicin.
authors.affiliation: Medizinische Klinik III, Klinikum Grosshadern, Universität München.
authors.forename: N
authors.initials: N
authors.lastname: Göldel
authors.forename: G
authors.initials: G
authors.lastname: Autenrieth
authors.forename: K
authors.initials: K
authors.lastname: Werdan
authors.forename: P
authors.initials: P
authors.lastname: Knesewitsch
authors.forename: W
authors.initials: W
authors.lastname: Wilmanns
mesh_terms: D000293:Adolescent; D000328:Adult; D000804:Angiotensin II; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000175:diagnosis; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000139:chemically induced / Q000175:diagnosis; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000804:Angiotensin II; D004317:Doxorubicin
vernacular_title: Echokardiographie unter Angiotensinbelastung zur Diagnostik der Adriamycinkardiomyopathie.