[Hemodynamic effects of etomidate in the child: a study of the dose-effect relation].
In order to determine haemodynamic effects of increasing etomidate dosage, 18 healthy anaesthetized children aged 3 to 8 years were randomly given etomidate as a bolus: 0.125 mg/kg (group I; n = 6), 0.25 mg/kg (group II; n = 6) or 0.5 mg/kg (group III; n = 6). Heart rate (HR), mean arterial pressure (MAP). Doppler aortic flow (DAF) and equivalents for systolic index (SI) and systemic vascular resistances (SVR) variations after etomidate administration were compared. Spearman's rank correlation test shows a significant relationship between increasing etomidate dosage and both decreased SI and increased SVR. This suggests to decrease dosage when reducing SI is unlikely.
Sfez
M
M
Département d'Anesthésie-Réanimation, Hôpital Jean-Verdier, Bondy, France.
Le Mapihan
Y
Y
Gaillard
J L
JL
Rosemblatt
J M
JM
D000769:Anesthesia, Inhalation; D001011:Aorta / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005045:Etomidate / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D005045:Etomidate
Effets hémodynamiques de l'étomidate chez l'enfant: étude de la relation effet-dose.