title: Coenuriasis in a spectacled langur (Presbytis obscura): praziquantel treatment and the antibody response to cyst antigens.
abstract: A diagnosis of coenuriasis was made in a spectacled langur raised in captivity. Multiple cysts removed from the subcutaneous tissues and later from the abdominal cavity were identified as coenuri, typical of the genus Taenia. Post-surgical treatment of the remaining cysts with praziquantel was assessed with whole body computerized tomography (CT). CT at 6 weeks post-treatment revealed a reduction in size and increased calcification of abdominal cysts as compared to pretreatment CT. Cyst fluid antigens in ELISA assays showed a high titer (1:5, 120) IgG response in the langur serum, while no IgM response could be detected. No decrease in IgG titer was seen 6 weeks after treatment. Immunoblot analyses identified several parasite-specific antigens with apparent molecular weights of greater than 92.5 (3 bands), 88, 41, 37, and 34 kDa.
authors.affiliation: Baylor College of Medicine, Houston, Texas.
authors.forename: T C
authors.initials: TC
authors.lastname: Price
authors.forename: M H
authors.initials: MH
authors.lastname: Dresden
authors.forename: T
authors.initials: T
authors.lastname: Alvarado
authors.forename: J
authors.initials: J
authors.lastname: Flanagan
authors.forename: C L
authors.initials: CL
authors.lastname: Chappell
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis; D000947:Antigens, Helminth / Q000276:immunology; D002520:Cercopithecidae / Q000469:parasitology*; D002590:Cestode Infections / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D015151:Immunoblotting; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D008992:Monkey Diseases / Q000188:drug therapy* / Q000276:immunology; D011223:Praziquantel / Q000627:therapeutic use*; D013621:Taenia / Q000276:immunology; D014057:Tomography, X-Ray Computed / Q000662:veterinary
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011223:Praziquantel