Progesterone inhibits the uterotrophic effect of relaxin in immature rats.
Injection of progesterone for 3 days before treatment with relaxin inhibited the trophic effect of the peptide in both estrogen-primed and unprimed uteri. The depression in collagen concentration and increase in apparent rate of proline incorporation into collagen induced by relaxin alone were also eliminated, indicating a fundamental blockade of the effect of relaxin in this experimental design as well as a close association of changes in collagen concentration with tissue hypertrophy. The effect of relaxin on incorporation of proline into soluble protein was not blocked by progesterone, however, suggesting a separate mechanism for this anabolic effect of relaxin.
Adams
W C
WC
Department of Biological Sciences, Kent State University, Kent, Ohio 44242.
Hanousek
C A
CA
Frieden
E H
EH
D000818:Animals; D003094:Collagen / Q000378:metabolism; D005260:Female; D009929:Organ Size / Q000187:drug effects; D009994:Osmolar Concentration; D010052:Ovariectomy; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012065:Relaxin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects* / Q000254:growth & development
D011374:Progesterone; D012065:Relaxin; D003094:Collagen