[Cerebrospinal fluid levels of sulbactam/ampicillin in rabbits with staphylococcal meningitis].
Concentrations of sulbactam (SBT) and ampicillin (ABPC) in the blood and cerebrospinal fluid (CSF) following an intravenous administration of SBT/ABPC at a dose of 150 mg/kg (SBT/ABPC = 1:2) were determined in 12 rabbits with staphylococcal meningitis. Drug concentrations were measured 9 times, 6 times each with intervals of 15 minutes and thereafter with intervals of 30 minutes. The results were compared with those of a group of 9 rabbits given 100 mg/kg of ABPC alone. 1. The maximum concentration of SBT in the CSF and the percentages of both the maximum concentration and the area under the concentration-time curve (AUC) of SBT in CSF vs. those in serum of the SBT/ABPC group were higher than those of ABPC and the half-life of SBT in the CSF was also longer than that of ABPC, all with significant difference. When these parameters for SBT of SBT/ABPC groups were compared with those of ABPC of the ABPC group, not much differences existed between the 2 groups except that the CSF half-life of SBT was much longer than that of ABPC. 2. The percentages of both the maximum concentration and AUC of ABPC in CSF vs. those in serum of the SBT/ABPC group were significantly lower than those of ABPC of the ABPC group. The CSF half-life of ABPC of the former group was longer than that of the latter. 3. The above results suggest that when SBT and ABPC are administered simultaneously, the penetration of ABPC into the CSF is inhibited.
Haruta
T
T
Department of Pediatrics, Kobe Central Municipal Hospital.
Okura
K
K
Kuroki
S
S
Yamamoto
H
H
Kobayashi
Y
Y
D000667:Ampicillin / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid*; D000818:Animals; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid; D007275:Injections, Intravenous; D008581:Meningitis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000209:etiology; D011817:Rabbits; D013203:Staphylococcal Infections; D013407:Sulbactam / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid*
D000667:Ampicillin; D013407:Sulbactam