Bombesin reverses bleeding-induced hypovolemic shock, in rats.
In an experimental model of bleeding-induced hypovolemic shock causing the death of all saline-treated rats within 26 +/- 4 min, the intravenous injection of bombesin (2.5, 5 or 10 micrograms/kg) dose-dependently restored blood pressure, pulse amplitude, heart rate and respiratory function, and improved survival rate as assessed at the end of the experiment (2 h). The effect on cardiovascular and respiratory functions was prompt (within 1-2 min) and sustained. The release of cholecystokinin seems to be the main mechanism of action, because the anti-shock effect of bombesin is largely prevented by the CCK-antagonist, L-364,718.
Guarini
S
S
Institute of Pharmacology, University of Modena, Italy.
Tagliavini
S
S
Bazzani
C
C
Bertolini
A
A
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D001839:Bombesin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors; D020109:Devazepide; D005260:Female; D006470:Hemorrhage / Q000150:complications*; D007275:Injections, Intravenous; D008297:Male; D011674:Pulse / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D012769:Shock / Q000209:etiology / Q000503:physiopathology*
D001570:Benzodiazepinones; D002766:Cholecystokinin; D020109:Devazepide; D001839:Bombesin