[Quantitative and qualitative changes in protein biosynthesis induced by hypoxia and transplantation of embryonic nerve tissue into the brain of adult mammals].
The changes in biochemical processes in brain cortex in rats with experimental hypoxia and hypoxia with consequent transplantation of embryonic nervous tissue into brain of adults have been studied. A small increase (2-3 times) in incorporation of biosynthesis precursors was observed as a result of transplantation both in normal and in hypoxic rats. These changes could be observed 100 days after the transplantation. These changes in biosynthesis led to selective increase in the amounts of 40-45 and 35-39 kDa proteins, which are characteristic both for local trauma caused by transplantation and for general one caused by hypoxia. The effect observed may be explained as a reaction of nervous cells on damage, and not on the presence of an embryonic brain transplant.
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D000818:Animals; D001923:Brain Chemistry; D003593:Cytoplasm / Q000032:analysis; D004591:Electrophoresis, Polyacrylamide Gel; D004622:Embryo, Mammalian; D005260:Female; D000860:Hypoxia / Q000378:metabolism*; D008970:Molecular Weight; D009417:Nerve Tissue / Q000637:transplantation*; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D013997:Time Factors
D009419:Nerve Tissue Proteins
Kolichestvennye i kachestvennye izmeneniia biosinteza belka, vyzvannye gipoksieĭ i transplantatsieĭ émbrional'noĭ nervnoĭ tkani v mozg v vzroslykh mlekopitaiushchikh.