title: Pyruvate kinase inhibited by L-cysteine as a marker of tumorigenic human urothelial cell lines.
abstract: It was found that a decrease in electrophoretic mobility of pyruvate kinase (PK) isoenzyme, and an increase of the sensitivity of this enzyme to L-cysteine, were markers of immortalization and tumorigenic properties, respectively, in human urothelial cell lines characterized by different grades of transformation (TGr) in vitro.
authors.affiliation: Institute of Medical Biochemistry, N. Copernicus Academy of Medicine, Kraków, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Gumińska
authors.forename: M B
authors.initials: MB
authors.lastname: Stachurska
authors.forename: B
authors.initials: B
authors.lastname: Christensen
authors.forename: V
authors.initials: V
authors.lastname: Tromholt
authors.forename: J
authors.initials: J
authors.lastname: Kieler
authors.forename: C
authors.initials: C
authors.lastname: Radzikowski
authors.forename: D
authors.initials: D
authors.lastname: Duś
mesh_terms: D014408:Biomarkers, Tumor; D002460:Cell Line; D002843:Chromatin / Q000302:isolation & purification; D003545:Cysteine / Q000494:pharmacology*; D004589:Electrophoresis, Disc; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D011770:Pyruvate Kinase / Q000032:analysis / Q000037:antagonists & inhibitors*
chemical_list: D014408:Biomarkers, Tumor; D002843:Chromatin; D007527:Isoenzymes; D011770:Pyruvate Kinase; D003545:Cysteine