title: Effect of large-bowel obstruction on colonic blood flow. An experimental study.
abstract: The effect of subacute large-bowel obstruction on the mesenteric circulation was studied in a chronic dog model. Colonic obstruction was produced 40 cm distal to the ileocolic sphincter. Five days later, gut blood flow was measured with 15 microns microspheres, together with hemodynamic and metabolic values. Two other groups provided comparative data: unoperated animals to measure baseline values and sham-operative controls. With adequate hydration, hemodynamic and metabolic values remained stable in the experimental group. There was a two-fold increase (P less than 0.05) in blood flow in the dilated colon proximal to the obstruction site, whereas blood flow to the other organs remained unchanged. These results have relevance for the hemodynamic management and use of primary anastomosis in patients with large-bowel obstruction. Furthermore, these data might implicate increased local bowel blood flow as a contributory factor to the poorer long-term prognosis found in patients with large-bowel cancer presenting with intestinal obstruction.
authors.affiliation: Department of Surgery, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: G
authors.initials: G
authors.lastname: Papanicolaou
authors.forename: Y K
authors.initials: YK
authors.lastname: Ahn
authors.forename: D J
authors.initials: DJ
authors.lastname: Nikas
authors.forename: L P
authors.initials: LP
authors.lastname: Fielding
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D002496:Central Venous Pressure; D003106:Colon / Q000098:blood supply*; D003108:Colonic Diseases / Q000503:physiopathology*; D003251:Constriction, Pathologic; D004285:Dogs; D005260:Female; D007415:Intestinal Obstruction / Q000503:physiopathology*; D007421:Intestine, Small / Q000098:blood supply; D008297:Male; D011669:Pulmonary Wedge Pressure; D011897:Random Allocation; D012039:Regional Blood Flow; D014655:Vascular Resistance