The effect of dietary restriction on myc protooncogene expression in mice: a preliminary study.
The effect of chronic dietary restriction on the expression of the c-myc protooncogene was determined in the livers of a hybrid mouse strain (C57Bl6 x C3H F1 hybrid) at three time points during a 24-h period: 1 h after lights on (1 HALO), 5 h prior to feeding (12 HALO), and 2 h after feeding (19 HALO). In addition, in whole animals studies, changes in core body temperature were monitored. In mice which had been subjected to a chronic diet restriction (60% of the intake of ad libitum controls), c-myc expression was significantly reduced at 1 HALO and 19 HALO compared to corresponding ad libitum animals. In addition, significant differences in c-myc expression were found between time points, in both the ad libitum and restricted groups, suggesting that myc protooncogene expression in the liver may be regulated in a circadian fashion. C-myc expression may correlate with body temperature, suggesting a possible association with metabolic output.
Nakamura
K D
KD
Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079.
Duffy
P H
PH
Lu
M H
MH
Turturro
A
A
Hart
R W
RW
D000818:Animals; D001831:Body Temperature; D002149:Energy Intake; D008017:Life Expectancy; D008099:Liver / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D011519:Proto-Oncogenes