Neurological outcome after out-of-hospital cardiac arrest. Prediction by cerebrospinal fluid enzyme analysis.
The prognostic value of cerebrospinal fluid (CSF) and serum neuron-specific enolase and brain-type creatine kinase isozyme (CK-BB) measurements was studied in 75 consecutive victims of out-of-hospital cardiac arrest. All patients with a CSF neuron-specific enolase level of more than 24 ng/mL 24 hours after cardiac arrest remained unconscious and died. The CSF CK-BB level was as reliable as an index of brain injury. Cerebrospinal fluid neuron-specific enolase, CSF CK-BB and serum neuron-specific enolase levels correlated with the neurological outcome at 3 months. Thus, the analysis of these enzymes in CSF seems to be useful in the early prognostic assessment of cardiac arrest victims.
Roine
R O
RO
Department of Neurology, University of Helsinki, Finland.
Somer
H
H
Kaste
M
M
Viinikka
L
L
Karonen
S L
SL
D000328:Adult; D000368:Aged; D003402:Creatine Kinase / Q000097:blood / Q000134:cerebrospinal fluid*; D006323:Heart Arrest / Q000097:blood / Q000134:cerebrospinal fluid* / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes; D008875:Middle Aged; D009420:Nervous System / Q000503:physiopathology*; D010751:Phosphopyruvate Hydratase / Q000097:blood / Q000134:cerebrospinal fluid*; D011379:Prognosis
D007527:Isoenzymes; D003402:Creatine Kinase; D010751:Phosphopyruvate Hydratase