Expression of a large family of POU-domain regulatory genes in mammalian brain development.
A novel region referred to as the POU-domain is present in two tissue-specific transcription factors, Pit-1 and Oct-2, that activate expression of genes specifying pituitary and lymphocyte phenotypes. We report the identification of multiple new members of a large family of POU-domain genes expressed in adult brain, and document that all the known mammalian POU-domain genes, including Pit-1 and Oct-2, are expressed widely in the developing nervous system.
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Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093-0613.
Treacy
M N
MN
Simmons
D M
DM
Ingraham
H A
HA
Swanson
L W
LW
Rosenfeld
M G
MG
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000196:embryology*; D005786:Gene Expression Regulation; D005796:Genes; D005809:Genes, Regulator; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D013116:Spinal Cord / Q000196:embryology; D014157:Transcription Factors / Q000235:genetics
D014157:Transcription Factors