Rat blood and brain amino acid pattern in short term experimental diabetes.
Some serum and brain amino acid variations occurring in animals with short term streptozotocin-diabetes (24 h) are studied in this work. Diabetic animals showed an increase in serum of the three branched-chain amino acids as well as an increase in free tryptophan, besides a decrease in total serum tryptophan and in the tryptophan/competitor amino acids ratio. In brain, the three branched-chain amino acids increased, but there were no variation in whole brain tryptophan. Nevertheless, by studying levels of tryptophan in different brain regions, an increase in medulla-pons was recorded. This circumstance could be explained by the increase in free serum tryptophan levels, in agreement with several authors who assign this reason for brain tryptophan.
Atienza
G
G
Departamento de Fisiología, Facultad de Biología, Santiago de Compostela, Spain.
Aldegunde
M
M
Veira
J A
JA
Lorenzo
A
A
Conejero
R
R
D000596:Amino Acids / Q000032:analysis* / Q000097:blood; D000818:Animals; D001923:Brain Chemistry; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014364:Tryptophan / Q000032:analysis* / Q000097:blood
D000596:Amino Acids; D014364:Tryptophan