title: Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells.
abstract: Genes expressed in erythroid cells contain binding sites for a cell-specific factor believed to be an important regulator for this haematopoietic lineage. Using high-level transient expression in mammalian cells, we have identified complementary DNA encoding the murine protein. The factor, a new member of the zinc-finger family of DNA-binding proteins, is restricted to erythroid cells at the level of RNA expression and is closely homologous between mouse and man.
authors.affiliation: Division of Hematology-Oncology, Children's Hospital, Boston, Massachusetts.
authors.forename: S F
authors.initials: SF
authors.lastname: Tsai
authors.forename: D I
authors.initials: DI
authors.lastname: Martin
authors.forename: L I
authors.initials: LI
authors.lastname: Zon
authors.forename: A D
authors.initials: AD
authors.lastname: D'Andrea
authors.forename: G G
authors.initials: GG
authors.lastname: Wong
authors.forename: S H
authors.initials: SH
authors.lastname: Orkin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000097:blood / Q000235:genetics*; D004912:Erythrocytes / Q000378:metabolism*; D050981:Erythroid-Specific DNA-Binding Factors; D005796:Genes; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics; D014157:Transcription Factors; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D050981:Erythroid-Specific DNA-Binding Factors; D012333:RNA, Messenger; D014157:Transcription Factors; D004247:DNA