title: HLA-B SNA antigen: a BW6 associated B locus antigen belonging to the B5 CREG.
abstract: A new B locus antigen has been found in members of two unrelated families and in a patient originating from Morocco belonging to the Berber population. A complete analysis has been performed with antisera from the 9th and 10th IHWS defining the B5 CREG antigens. Serology, absorption experiments and family studies indicate that SNA antigen is a Bw6 associated subtype of B5 antigen closely related to but clearly distinct from each of the B5 CREG antigens. One-dimensional isoelectric focusing study (1D-IEF) confirms that the SNA antigen precipitates as a B locus gene product and has an isoelectric point identical to that of Bw52 and one of the charge variants of B51.
authors.affiliation: Department of Immunology, Hematology and Transfusion, Erasme Hospital, Cliniques Universitaires de Bruxelles, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Andrien
authors.forename: P
authors.initials: P
authors.lastname: Reekers
authors.forename: P
authors.initials: P
authors.lastname: Stordeur
authors.forename: M
authors.initials: M
authors.lastname: Vandercruys
authors.forename: E
authors.initials: E
authors.lastname: Dupont
mesh_terms: D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D015235:HLA-B Antigens / Q000032:analysis*; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D007120:Immunochemistry; D007526:Isoelectric Point; D010375:Pedigree
chemical_list: D015235:HLA-B Antigens; C035270:HLA-B5 antigen; C038652:HLA-Bw6 antigen