[The dependence of the carcinogenic effect on the concentration of N-nitrosodiethylamine].
In a 86-week-long experiment using 1087 mice (487 hybrids and 600 non-inbred animals), the concentration-effect relationship was studied for N-nitrosodiethylamine (NDEA) given in drinking water. NDEA concentrations of 0.08; 0.4; 2.0 and 10.0 mg/l produced tumors in male and female hybrids with the frequencies of 35.9/30.9, 49.9/43.6, 61.9/72.3 and 81.8/82.9%, respectively (20.0.20.0% in controls) whereas in non-inbred animals the frequencies were 15.6/34.2, 24.2/33.3, 35.9/57.1 and 78.4/80.9%, respectively (15.0/30.0% in controls). The "minimal effective" carcinogenic level of NDEA proved 0.4 mg/l for hybrids and 2.0 mg/l for non-inbred mice (P less than 0.05). No sex differences were found for frequency or histologic pattern of tumor. The data obtained can be used in calculating sanitary-hygienic standards for NDEA.
Voronin
V M
VM
Litvinov
N N
NN
Kazachkov
V I
VI
Shamarin
A A
AA
Zhurkov
V S
VS
D000818:Animals; D004052:Diethylnitrosamine / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008452:Maximum Allowable Concentration; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology; D012727:Sex Characteristics
D004052:Diethylnitrosamine
Izuchenie zavisimosti kantserogennogo éffekta ot kontsentratsii N-nitrozodiétilamina.