Cerebrospinal fluid nucleotide metabolites following non-convulsive status epilepticus.
The authors studied specific and sensitive indicators of neuronal adenosine triphosphate (ATP) depletion--hypoxanthine, xanthine and uridine levels--in the cerebrospinal fluid (CSF) of nine children during non-convulsive status epilepticus. No evidence of ATP depletion was found and CSF pH and creatine kinase levels were similar to those of controls. Hypoxanthine, xanthine and uridine had a tendency to be low, but this was significant only for xanthine. The authors speculatively link this reduction to a reduction in neuronal protein synthesis. This might be a mechanism whereby non-convulsive status epilepticus could lead to intellectual deterioration and dementia.
Livingston
J H
JH
Department of Paediatric Neurology, Royal Hospital for Sick Children, Edinburgh.
Brown
J K
JK
Harkness
R A
RA
McCreanor
G M
GM
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000134:cerebrospinal fluid*; D002534:Hypoxia, Brain / Q000134:cerebrospinal fluid; D007223:Infant; D008297:Male; D003294:Seizures, Febrile / Q000134:cerebrospinal fluid; D013036:Spasms, Infantile / Q000134:cerebrospinal fluid; D013226:Status Epilepticus / Q000134:cerebrospinal fluid*; D014529:Uridine / Q000134:cerebrospinal fluid*; D019820:Xanthine; D014970:Xanthines / Q000134:cerebrospinal fluid*
D007042:Hypoxanthines; D014970:Xanthines; D019820:Xanthine; D019271:Hypoxanthine; D014529:Uridine