Pancytopenia, rash and fever caused by diethylstilbestrol used for prostate cancer.
Pancytopenia, rash, and fever developed in a 66-year-old man being treated for metastatic prostate cancer with diethylstilbestrol (DES). Only the withdrawal of DES resulted in the prompt resolution of symptoms, signs, and laboratory manifestations. Both immunologic and endocrinologic mechanisms are implicated and must be considered by physicians using DES for the palliative management of prostate cancer.
Collins
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University of Mississippi, Jackson.
D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010198:Pancytopenia / Q000139:chemically induced*; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D014581:Urticaria / Q000139:chemically induced*
D004054:Diethylstilbestrol