[Plasma levels of biogenic amines in patients with various forms of the alcohol abstinence syndrome].
Norepinephrine (NE), dopamine (DA) and serotonin (5-HT) blood plasma levels were measured in 40 alcoholic patients (2nd stage) during overt manifestations of the alcohol abstinence syndrome (AAS). Twenty-five healthy individuals served as controls. The patients were divided into four groups according to the structure of their AAS-related psychopathology and the progress of the disease. In the fast-progressive group with autonomic disorders prevalent in the AAS structure, the excitability, NE and DA levels were elevated. In the group with prevalent asthenic-neurotic and affective disorders, the 5-HT levels were lower than controls. The group with fast-progressive course of the disease and schizoaffective disorders had both the 5-HT and NE levels lowered. The authors discuss the possible impact of the results on perfectioning of the differential AAS therapies.
Treskov
V G
VG
Agafonov
G V
GV
Tsirenina
M L
ML
Koltovaia
N A
NA
Mel'nik
E I
EI
D000328:Adult; D003527:Cyclothymic Disorder / Q000139:chemically induced; D003866:Depressive Disorder / Q000139:chemically induced; D004837:Epinephrine / Q000097:blood*; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000139:chemically induced*; D009638:Norepinephrine / Q000097:blood*; D012701:Serotonin / Q000097:blood*; D013375:Substance Withdrawal Syndrome / Q000523:psychology*
D012701:Serotonin; D000431:Ethanol; D009638:Norepinephrine; D004837:Epinephrine
Soderzhanie biogennykh aminov v plazme krovi u bol'nykh s razlichnymi formami alkogol'nogo abstinentnogo sindroma.