Studies on Leber's optic neuropathy III.
Neurological investigations, HLA-typing and viral antibody studies were performed in patients with Leber's optic neuropathy (LON), in individuals at risk to develop the disease, in obligatory (female) carriers of the disease, and compared with controls. The only relevant findings were an excess of minor neurological abnormalities in patients with LON and in some individuals from the at risk group. Occasionally, an association of LON and a multiple sclerosis-like picture was observed.
Palan
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Department of Human Genetics, Faculty of Medicine, Sylvius Laboratories, Leiden, The Netherlands.
Stehouwer
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Went
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LN
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D003168:Complement Fixation Tests; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D015417:Hereditary Sensory and Motor Neuropathy / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D015418:Optic Atrophies, Hereditary / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D012307:Risk Factors; D012737:Sex Factors; D014780:Viruses / Q000276:immunology
D000914:Antibodies, Viral; D006680:HLA Antigens