title: Castor oil increases intestinal formation of platelet-activating factor and acid phosphatase release in the rat.
abstract: 1. When castor oil was administered by gavage to rats, the duodenum and jejunum but not ileum and colon produced large amounts (5-6 fold greater than control) of platelet activating factor (Paf). 2. Intraluminal release of acid phosphatase (AP) was also markedly increased (5-6 fold greater than control) in the duodenum and jejunum of castor oil-treated rats and there was a correlation between the elevated release of AP and intestinal hyperaemia. 3. These findings support a role for Paf as a mediator of intestinal damage induced by castor oil.
authors.affiliation: Department of Experimental Pharmacology, University of Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pinto
authors.forename: A
authors.initials: A
authors.lastname: Calignano
authors.forename: N
authors.initials: N
authors.lastname: Mascolo
authors.forename: G
authors.initials: G
authors.lastname: Autore
authors.forename: F
authors.initials: F
authors.lastname: Capasso
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism*; D000284:Administration, Oral; D000818:Animals; D002368:Castor Oil / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000201:enzymology; D008297:Male; D010972:Platelet Activating Factor / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010972:Platelet Activating Factor; D002368:Castor Oil; D000135:Acid Phosphatase