title: Uterine development and endocrine relationships after menarche.
abstract: Uterine volume and ovarian/uterine ratio during the first 6 postmenarchal years in 143 women were compared with an adult control group. Plasma gonadotropins and sex steroids were also correlated with uterine volume in adolescents. Uterine volume increased progressively and correlated positively with advancing postmenarchal (r = 0.24; p less than 0.05) and chronologic (r = 0.23; p less than 0.05) age. However, normal adult uterine volume was not yet reached by the highest postmenarchal (6 years) and chronologic (18 years) age. The ovarian/uterine ratio decreased gradually with increasing postmenarchal age but was always higher (0.22) than that of control subjects (0.12). Uterine volume correlated positively with plasma estradiol (r = 0.25; p less than 0.05) and dehydroepiandrosterone (r = 0.22; p less than 0.05) and its sulfate (r = 0.22; p less than 0.05) levels. This study indicates that the uterus continues to grow after menarche in conjunction with increasing hormone levels.
authors.affiliation: Department of Reproductive Physiology and Pathology, University of Bologna, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Porcu
authors.forename: S
authors.initials: S
authors.lastname: Venturoli
authors.forename: R
authors.initials: R
authors.lastname: Fabbri
authors.forename: L F
authors.initials: LF
authors.lastname: Orsini
authors.forename: E
authors.initials: E
authors.lastname: Sganga
authors.forename: L
authors.initials: L
authors.lastname: Brondelli
authors.forename: R
authors.initials: R
authors.lastname: Paradisi
authors.forename: C
authors.initials: C
authors.lastname: Flamigni
mesh_terms: D000293:Adolescent; D000375:Aging / Q000502:physiology; D004702:Endocrine Glands / Q000502:physiology*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D008572:Menarche; D008597:Menstrual Cycle; D014599:Uterus / Q000254:growth & development*
chemical_list: D012739:Gonadal Steroid Hormones