Studies on the genotoxicity of asataf (acephate), an organophosphate insecticide, in a mammalian in vivo system.
The genotoxic potential of asataf (acephate) was evaluated by a battery of in vivo tests: bone marrow chromosome aberrations, micronucleus, sperm-shape abnormality and dominant lethal tests in mice. A significant enhancement in the percentage of chromosome aberrations was noticed in 3 doses, 3 routes and 3 h after asataf treatment of groups of mice as well as in chronic (sub-acute) treatment. A significant difference in the occurrence of micronuclei was found only at the highest dose whereas all the results of the sperm-shape abnormality test were highly significant. In the dominant lethal mutagenicity assay only the result (dead implants) of a single week (3rd) with the higher dose differed significantly from control. On the basis of the present in vivo results in mouse test systems asataf may be considered to be a potential mutagen.
Behera
B C
BC
P.G. Department of Zoology, Utkal University, Bhubaneswar, Orissa, India.
Bhunya
S P
SP
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D005804:Genes, Lethal; D066298:In Vitro Techniques; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D063088:Phosphoramides; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects
D007306:Insecticides; D009946:Organothiophosphorus Compounds; D063088:Phosphoramides; C001969:acephate