Enhanced degradation of platelet-activating factor in serum from diabetic patients.
The degradation of platelet-activating factor (PAF) and lipid concentrations were measured in sera from 20 patients with insulin-dependent diabetes mellitus and from 20 age- and sex-matched healthy volunteers. The PAF-degrading capacity as well as triglycerides and total and very low density and low-density lipoprotein cholesterol were found to be significantly increased in the patients group, whereas the difference observed in high-density lipoprotein cholesterol was statistically nonsignificant. There were also a series of close relationships between the degradation of PAF and some lipid variables in the control group. These results confirm the parallel changes of lipoproteins and PAF-degrading capacity described previously in serum from atherosclerotic patients and extend it to patients suffering from diabetes mellitus.
Hofmann
B
B
Institut für Pathologische Biochemie, Medizinische Akademie, Erfurt, DDR.
Rühling
K
K
Spangenberg
P
P
Ostermann
G
G
D000328:Adult; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010972:Platelet Activating Factor / Q000378:metabolism*; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D010972:Platelet Activating Factor; D014280:Triglycerides; D002784:Cholesterol