Amoxycillin/clavulanic acid (Augmentin)-induced intrahepatic cholestasis.
A 75-year-old man developed a biopsy-proven, drug-induced intrahepatic cholestasis after use of amoxycillin trihydrate combined with the beta-lactam inhibitor potassium clavulanate (Augmentin). Cholestatic liver injury is an uncommonly recognized, probably immunologically based adverse reaction to therapy with penicillin and its derivatives.
Dowsett
J F
JF
Department of Gastroenterology, University College and Middlesex Hospital, Medical School, U.K.
Gillow
T
T
Heagerty
A
A
Radcliffe
M
M
Toadi
R
R
Isle
I
I
Russell
R C
RC
D000368:Aged; D000658:Amoxicillin / Q000009:adverse effects*; D019980:Amoxicillin-Potassium Clavulanate Combination; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000473:pathology; D002969:Clavulanic Acids / Q000009:adverse effects*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male
D002969:Clavulanic Acids; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin