Is the proportion of hypoxic cells in a solid tumour dependent on the host (mouse or rat)?
Hypoxic cell fraction was measured in a human tumour xenografted on two different animal species: mouse and rat. These results suggest that, while the Na11 tumour response to radiation depends on the host (nude mouse, nude rat), the proportion of hypoxic cells tested with the growth delay assay is independent of the host.
Guichard
M
M
Laboratoire de radiobiologie cellulaire (Unité Inserm 247), Institut Gustave Roussy, Villejuif, France.
Chavaudra
N
N
Malaise
E P
EP
D000818:Animals; D002452:Cell Count; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D011923:Rats, Nude; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy; D013045:Species Specificity
D010100:Oxygen