title: Leucine kinetics in surgical patients. II: A study of the effect of malignant disease and tumour burden.
abstract: Isotope studies of protein turnover have given conflicting evidence about the effects of a malignant tumour on the protein metabolism of the host. Leucine kinetics have been studied, as an index of protein turnover, using a well established methodology. Twenty patients were studied, five with benign disease of the colon, ten with localized malignant tumours of the large bowel, and five in whom there was evidence of metastatic disease from a colonic primary. No effect was observed on the leucine turnover of the patients that might be attributable to the presence or size of the tumour burden. It is suggested that some of the previously conflicting results may be attributable to variability in the experimental design, the heterogeneous patient groups studied and the methods used to express the results obtained.
authors.affiliation: Department of Surgery, University College London, UK.
authors.forename: R A
authors.initials: RA
authors.lastname: Harrison
authors.forename: M R
authors.initials: MR
authors.lastname: Lewin
authors.forename: D
authors.initials: D
authors.lastname: Halliday
authors.forename: C G
authors.initials: CG
authors.lastname: Clark
mesh_terms: D000368:Aged; D001823:Body Composition; D001835:Body Weight; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000601:surgery; D005260:Female; D006801:Humans; D007700:Kinetics; D007930:Leucine / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011300:Preoperative Care; D014176:Protein Biosynthesis; D012004:Rectal Neoplasms / Q000378:metabolism
chemical_list: D007930:Leucine