Portal hypertension ameliorates arterial hypertension in spontaneously hypertensive rats.
Systemic hemodynamic effects of portal hypertension in arterial hypertension and their relationship to serum bile acid levels were investigated using spontaneously hypertensive rats 2 and 15 weeks after partial portal vein ligation (SHR-PVL) or sham operation (SHR-SH) and normotensive controls. Mean arterial pressure in SHR-PVL at 2 weeks was decreased to normal due to a decrease in peripheral resistance. Mean arterial pressure and peripheral resistance in SHR-PVL at 15 weeks did not differ from SHR-SH. Resolution of this arterial hypotensive effect and systemic hyperdynamic circulation was associated with decreased portal-systemic shunting. Bile acid levels were increased in both SHR-PVL groups. These results suggest that an endogenous circulating vasodilator(s) associated with portal hypertension ameliorates the systemic vasoconstriction in SHR. Bile acids, while not direct mediators of these hemodynamic events, may be prototypic of this vasodilator. This arterial hypertensive model may aid further investigation of the mechanisms contributing to the hyperdynamic state in portal hypertension.
Polio
J
J
Hepatic Hemodynamic Laboratory, VA Medical Center, West Haven, CT 06516.
Groszmann
R J
RJ
Reuben
A
A
Sterzel
R B
RB
Better
O S
OS
D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood; D001835:Body Weight; D006439:Hemodynamics; D006973:Hypertension / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D006975:Hypertension, Portal / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009929:Organ Size; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D014661:Vasoconstriction
D001647:Bile Acids and Salts