[Diagnostico-prognostic significance of the analysis of anti-HIV antibodies and viral antigens in acquired immunodeficiency syndrome. Presentation of 2 paradigmatic cases].
The authors, after reviewing the current literature about the serological pattern of anti-HIV antibodies detected with Western Blot and the research of the viral antigen in AIDS, report the study of the above mentioned parameters in two HIV seropositive drug addicts. Case 1 (symptomless seropositive) presented a reactivity against p24 and p55 a month after an acute HIV infection and a more delayed reactivity to the whole anti-HIV antibody pattern. Case 2 (which developed full-blown AIDS), together with clinical and immunological deterioration, had a decline and disappearance of antibodies to p24 and persistence of reactivity against gp41 and detection of viral antigen. Diagnostic and prognostic significance of these results are discussed.
Venturini
L
L
Serpelloni
G
G
Parolin
A
A
Mezzelani
P
P
D000386:AIDS-Related Complex / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000276:immunology*; D000328:Adult; D015153:Blotting, Western; D015483:HIV Antibodies / Q000032:analysis*; D015488:HIV Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D011379:Prognosis
D015483:HIV Antibodies; D015488:HIV Antigens
Significato diagnostico-prognostico della ricerca degli anticorpi anti-HIV e dell'antigene virale nella sindrome da immunodeficienza acquisita. Presentazione di due casi paradigmatici.