title: Identification of 1,4-thiomorpholine-3-carboxylic acid (TMA) in normal human urine.
abstract: The sulfur-containing cyclic imino acid 1,4-thiomorpholine-3-carboxylic acid (TMA) has been identified in normal human urine. After the enrichment procedure with ion-exchange chromatography, the urine extracts were reacted with diazomethane. Gas-liquid chromatography revealed the presence of two peaks with the same retention times exhibited by authentic TMA after the same derivatization. The two compounds have been identified by mass-spectrometry as the monomethylated and dimethylated derivatives of TMA. This result represents the first indication of the occurrence of TMA in a mammalian sample.
authors.affiliation: Dipartimento di Scienze Biochimiche e Centro di Biologia Molecolare del CNR, Università di Roma La Sapienza, Italy.
authors.forename: R M
authors.initials: RM
authors.lastname: Matarese
authors.forename: S P
authors.initials: SP
authors.lastname: Solinas
authors.forename: G
authors.initials: G
authors.lastname: Montefoschi
authors.forename: G
authors.initials: G
authors.lastname: Ricci
authors.forename: D
authors.initials: D
authors.lastname: Cavallini
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007098:Imino Acids / Q000652:urine*; D009025:Morpholines / Q000652:urine*; D012016:Reference Values
chemical_list: D007098:Imino Acids; D009025:Morpholines; C060165:1,4-thiomorpholine-3-carboxylic acid