The fate of cimetidine sulphoxide in the guinea pig.
1. An oral dose of cimetidine given to guinea pigs was totally excreted in 3 days, divided equally between urine and faeces. 2. Only 40% of an oral dose of cimetidine sulphoxide was voided in 3 days, the remainder being found in the mesentery and omental tissues. 3. In contrast, 90% of an i.v. dose of cimetidine sulphoxide was excreted in urine in 24 h. 4. Approx. 20% of an oral dose of both cimetidine (17.2%) and cimetidine sulphoxide (24.9%) was secreted in bile during the first day. 5. The major metabolic routes encountered were sulphoxidation and sulphoxide reduction.
Mitchell
S C
SC
Department of Pharmacology & Toxicology, St. Mary's Hospital Medical School, Paddington, London, UK.
Waring
R H
RH
D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000032:analysis*; D002927:Cimetidine / Q000031:analogs & derivatives* / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D006168:Guinea Pigs; D008658:Inactivation, Metabolic; D007275:Injections, Intravenous; D008297:Male; D014018:Tissue Distribution; D014316:Tritium / Q000652:urine
D014316:Tritium; D002927:Cimetidine; C034042:cimetidine sulfoxide