title: Magnetic resonance imaging of the ischemic hip. Alterations within the osteonecrotic, viable, and reactive zones.
abstract: To explore the ability of magnetic resonance imaging (MRI) to depict the morphologic features of avascular necrosis (AVN) of the femoral head and to determine whether a classification based on stage of necrosis is possible, images of hips with 56 proved lesions were examined and correlated with roentgenographic stage, severity of pain and functional impairment, and available computed tomography (CT) scans. Six femoral heads with AVN were also studied ex vivo with MRI, CT, roentgenographic, and histologic examinations. These examinations were compared with 100 normal hips in 50 individuals and one normal proximal femoral specimen. The reactive interface between live and dead bone at the periphery of AVN lesions had a characteristic MRI appearance that facilitated diagnosis. Based on central signal intensity on two different pulse sequences, lesions could be separated into four classes that correlated with roentgenographic and clinical staging. Lesions that were isointense with fat on both sequences had an earlier roentgenographic stage and less severe symptoms than did lesions that were less intense than fat. Among hips with AVN in patients younger than 50 years of age, 67% had premature conversion to fatty intertrochanteric marrow outside the borders of the lesion. Detecting premature conversion to fatty marrow has important implications regarding the pathogenesis of AVN and may aid early diagnosis. MRI provides pathophysiologic information that is different from information obtained from conventional methods or various combinations of methods and may provide a basis for an improved system for grading AVN lesions.
authors.affiliation: Hospital of the University of Pennsylvania, Philadelphia.
authors.forename: D G
authors.initials: DG
authors.lastname: Mitchell
authors.forename: M E
authors.initials: ME
authors.lastname: Steinberg
authors.forename: M K
authors.initials: MK
authors.lastname: Dalinka
authors.forename: V M
authors.initials: VM
authors.lastname: Rao
authors.forename: M
authors.initials: M
authors.lastname: Fallon
authors.forename: H Y
authors.initials: HY
authors.lastname: Kressel
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D005271:Femur Head Necrosis / Q000175:diagnosis*; D006410:Hematopoiesis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013582:Synovial Fluid / Q000032:analysis; D014057:Tomography, X-Ray Computed