[RBE of neutrons from the BR-10 reactor based on their antitumor effect and on acute radiation reactions of the skin].
The paper is concerned with the results of investigation of antitumor effectiveness (rats, sarcoma M-1) of neutron radiation of a BR-10 reactor with the mean energy of 0.85 MeV, correlated with the effect of 60Co gamma radiation (Luch-1). RBE in single local tumor radiation with neutrons was 4.5, being higher than RBE based on acute skin radiation reactions over a tumor (4.0). For this case FTA is over I (1.13) but slightly lower than after dose fractionated irradiation (1.18). Experimental data indicate the necessity of extending the clinical use of reactor neutrons and a profound study of the effects after neutron irradiation, particularly in dose-fractionated regimens.
Kuznetsova
M N
MN
Ul'ianenko
S E
SE
D000208:Acute Disease; D000818:Animals; D005214:Fast Neutrons; D005720:Gamma Rays / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D009368:Neoplasm Transplantation; D009502:Neutrons; D009688:Nuclear Reactors; D011855:Radiodermatitis / Q000209:etiology*; D011879:Radiotherapy Dosage; D051381:Rats; D012044:Regression Analysis; D012062:Relative Biological Effectiveness; D012513:Sarcoma, Experimental / Q000532:radiotherapy*; D013997:Time Factors
OBE neĭtronov reaktora BR-10 po protivoopukholevomu éffektu i ostrym luchevym reaktsiiam kozhi.