[Liver function and lipid peroxidation in indomethacin-induced damage].
Administration of indomethacin in a dose of 0.01 and especially in a dose of 0.02 mg/kg body weight three times was found to cause a severe damage of the liver. It manifested itself in an increase of the activity of aminotransferases and alkaline phosphatase in blood serum, an increase of peroxidation of lipids of hepatocytic membranes, a decrease of reserves of restored glutathione, a disturbance of the functional state of the liver. The increase of lipid peroxidation is thought to play an important role in the pathogenesis of such lesions.
Klimniuk
E V
EV
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007213:Indomethacin / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007213:Indomethacin
Funktsional'noe sostoianie pecheni i perekisnoe okislenie lipidov pri porazhenii ee indometatsinom.