Interrelationship between plasma ionized calcium, plasma noradrenaline (NA) and pressor response to infused NA in patients with essential hypertension.
We evaluated the role of calcium metabolism on plasma noradrenaline concentration (pNA) and pressor response to infused noradrenaline (NA-R) in patients with mild-to-moderate essential hypertension (EHT). Mean arterial pressure (MAP), plasma ionized calcium (pCa2+), and NA-R were measured at the basal condition in 17 EHT and after the administration of calcium antagonist, nifedipine (60mg, t.i.d., for 4 weeks) in 9 EHT. Under basal condition, pCa2+ correlated positively with pNA and negatively with NA-R in EHT. Following nifedipine therapy, persistent reductions of MAP and NA-R, a transient increase in pNA and a sustained increase of urinary excretion of calcium were observed. On the other hand, no significant change in pCa2+ was found during the therapy. Percent change in MAP following 4 weeks of nifedipine administration correlated positively with pCa2+ and pNA before the therapy. In addition, change in NA-R by nifedipine therapy correlated positively with the basal values of pCa2+ and PNA and negatively with NA-R before the treatment. A significant negative correlation between NA-R and pNA was observed following nifedipine therapy as well as the basal state. However, the slope of the regression line between NA-R and pNA decreased significantly after the treatment as compared to the basal state. These results suggest that calcium metabolism relating sympathetic nerve activity and NA-R may contribute to the hypertensive mechanism in EHT. The hypotensive effects of nifedipine may be caused partly by the attenuation of sympathetic nerve activity and NA-R.
Nozawa
A
A
2nd Department of Internal Medicine, Sapporo Medical College, Japan.
Kikuchi
K
K
Nishimura
M
M
Hasegawa
T
T
Honma
C
C
Komura
H
H
Kobayakawa
H
H
Suzuki
S
S
Yamamoto
M
M
Shimazaki
S
S
D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D007262:Infusions, Intravenous; D007477:Ions; D009543:Nifedipine / Q000494:pharmacology; D009638:Norepinephrine / Q000097:blood* / Q000494:pharmacology; D009994:Osmolar Concentration
D007477:Ions; D009543:Nifedipine; D002118:Calcium; D009638:Norepinephrine