Brain sulfide levels in anaesthesia: a comparison with hydrogen sulfide intoxication.
Although sublethal concentrations of hydrogen sulfide produce a state not unlike anaesthesia, measurement of rat brain sulfide levels by gas dialysis and IC with electrochemical detection after either 1.5 g/kg urethane or 42 mg/kg pentobarbital failed to demonstrate any changes as compared with endogenous brain sulfide levels of saline-injected controls. This suggests that the mechanisms underlying anaesthesia are not directly linked to endogenous cerebral sulfide levels.
Warenycia
M W
MW
Department of Pharmacology, University of Alberta, Edmonton, Canada.
Reiffenstein
R J
RJ
Goodwin
L R
LR
Dieken
F P
FP
D000758:Anesthesia; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D006862:Hydrogen Sulfide / Q000506:poisoning*; D008297:Male; D010424:Pentobarbital; D051381:Rats; D011919:Rats, Inbred Strains; D013440:Sulfides / Q000032:analysis*; D014520:Urethane
D013440:Sulfides; D014520:Urethane; D010424:Pentobarbital; D006862:Hydrogen Sulfide