Effect of V-9-M, a peptide fragment derived from procholecystokinin, on memory processes in the rat.
It has been reported that a nonapeptide (Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met) called V-9-M is produced from procholecystokinin in the brain. Since this peptide is particularly abundant in the hippocampus, septum, and amygdala. V-9-M may be involved in memory processes. The present study was attempted to observe the effect of V-9-M on memory processes of rat performing a one-trial passive avoidance task and a platform jumping active avoidance task. The results indicate that injection of V-9-M into the lateral ventricle of the rat prevents experimental amnesia induced by electroconvulsive shock in passive avoidance testing, and that this effect is not significantly affected by cholecystokinin-8 antagonists. V-9-M also causes a long-lasting enhancement of memory in the active avoidance task. These results suggest that V-9-M may participate in the facilitation of memory.
Takashima
A
A
Shionogi Research Laboratories, Osaka, Japan.
Itoh
S
S
D000647:Amnesia / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002766:Cholecystokinin / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004597:Electroshock; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D008568:Memory / Q000187:drug effects*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D011377:Proglumide / Q000494:pharmacology; D011498:Protein Precursors / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D010446:Peptide Fragments; D011498:Protein Precursors; C060249:procholecystokinin; D002766:Cholecystokinin; C060250:V-9-M cholecystokinin nonapeptide; D011377:Proglumide