title: Is adjuvant systemic therapy necessary for all axillary node negative breast cancer patients?
abstract: One hundred eighty-six breast cancer patients with either T1 or T2 primary tumors and negative axillary lymph nodes (N-) underwent only local therapy at Norwalk Hospital from 1978-83. No adjuvant chemotherapy or hormone therapy was given for this favorable group of patients. The actuarial five-year disease free (NED) survival rate for these (N-) patients was 91% (+/- 3%, 95% confidence limits) and the ten-year NED survival rate was 79% (+/- 8%). These NED survival rates are vastly superior to the NED survival rates quoted by the National Cancer Institute (NCI) Clinical Alert for (N-) breast cancer patients who received no adjuvant therapy (67%-77% at three to four years median follow-up time). The NCI Clinical Alert is based on three clinical trials which included (N-) patients with larger tumors than T1 or T2 and excluded patients with small primary tumors. Based on these three clinical trials which demonstrated improved NED survival for (N-) patients treated with adjuvant therapy compared to nontreated patients, the NCI Clinical Alert recommended that adjuvant therapy be considered for all (N-) patients. We conclude that it is premature to recommend that all (N-) breast cancer patients should routinely receive adjuvant therapy until more information is available.
authors.forename: P M
authors.initials: PM
authors.lastname: Pathare
authors.forename: R E
authors.initials: RE
authors.lastname: Peschel
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000628:therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D012189:Retrospective Studies