Synthesis and antibacterial activity of 5-methylcarbapenems.
Four possible racemic isomers of N-acetyl-5-methylthienamycin derivatives were synthesized and their antibacterial activities are discussed in relation to their physico-chemical properties. 5-Methylcarbapenems having various C-2 side chains were also prepared.
Onoue
H
H
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Narukawa
Y
Y
D001419:Bacteria / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D007536:Isomerism; D015394:Molecular Structure; D013845:Thienamycins / Q000138:chemical synthesis / Q000494:pharmacology*
D013845:Thienamycins