Sch 38519, a novel platelet aggregation inhibitor produced by a Thermomonospora sp. Taxonomy, fermentation, isolation, physico-chemical properties, structure and biological properties.
The complex containing a new platelet aggregation inhibitor, Sch 38519, was recovered from the fermentation filtrate of Thermomonospora sp. SCC 1793. A chemically defined medium was developed which favored the production of Sch 38519. The antibiotic was isolated from the fermentation filtrate by absorption on macroreticular resin and further purified by ion exchange chromatography and reverse phase HPLC. Sch 38519 is an isochromanequinone structurally related to medermycin, lactoquinomycin and granaticin. It inhibits thrombin-induced aggregation of human platelets with an IC50 of 68 micrograms/ml. Sch 38519 is also active against Gram-positive and Gram-negative bacteria.
Patel
M
M
Schering Corporation, Bloomfield, NJ 07003.
Hegde
V
V
Horan
A
A
Barrett
T
T
Bishop
R
R
King
A
A
Marquez
J
J
Hare
R
R
Gullo
V
V
D000192:Actinomycetales / Q000145:classification / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D002852:Chromatography, Ion Exchange; D005285:Fermentation; D005374:Filtration; D005663:Furans / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D005663:Furans; D010975:Platelet Aggregation Inhibitors; C060471:Sch 38519