Pefloxacin treatment of meningitis caused by gram-negative bacteria.
Ten patients with acute meningitis caused by gram-negative bacteria were treated with pefloxacin intravenously for a mean period of 10 days. Eight patients responded clinically to pefloxacin treatment, and the causative organisms were eradicated from the cerebrospinal fluid in 9 of the 10 patients. Pefloxacin may offer a new, efficacious, and safe therapy for gram-negative meningitis.
Segev
S
S
Infectious Diseases Unit, Chaim Sheba Medical Center, Tel-Aviv University Medical School, Tel-Hashomer, Israel.
Barzilai
A
A
Rosen
N
N
Joseph
G
G
Rubinstein
E
E
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008581:Meningitis / Q000188:drug therapy* / Q000382:microbiology; D008875:Middle Aged; D015366:Pefloxacin / Q000097:blood / Q000627:therapeutic use*; D011379:Prognosis
D015366:Pefloxacin