title: The alternative hypothesis: one-sided or two-sided?
abstract: The appropriateness of a one-sided alternative hypothesis rather than the more conservative, boiler-plate, two-sided hypothesis is discussed and examples provided. It is concluded that confirmatory efficacy clinical trials of pharmaceutical compounds should always be viewed within the one-sided alternative hypothesis testing framework.
authors.affiliation: Parke-Davis Research Division, Warner-Lambert Company, Ann Arbor, MI 48105.
authors.forename: K E
authors.initials: KE
authors.lastname: Peace
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D004341:Drug Evaluation / Q000379:methods*; D006801:Humans; D013223:Statistics as Topic