title: Cytotoxicity of isoquinoline alkaloids and their N-oxides.
abstract: A series of 53 isoquinoline alkaloids and their N-oxides have been tested for their cytotoxicity against A-549, HCT-8, KB, P-388, and L-1210 cells. These alkaloids include two tetrahydroprotoberberines, two protoberberines, six aporphines, one morphinandienone, five oxoaporphines, seven phenanthrenes, one spirobenzylisoquinoline N-oxide, nine aporphine N-oxides, seven benzyltetrahydroisoquinoline N-oxides, one benzylisoquinoline N-oxide, one protopine N-oxide, three tetrahydroprotoberberine N-oxides, four pavine N-oxides, and four phenanthrene N-oxides. The results are discussed on the basis of structure-activity relationships.
authors.forename: Y C
authors.initials: YC
authors.lastname: Wu
authors.forename: Y F
authors.initials: YF
authors.lastname: Liou
authors.forename: S T
authors.initials: ST
authors.lastname: Lu
authors.forename: C H
authors.initials: CH
authors.lastname: Chen
authors.forename: J J
authors.initials: JJ
authors.lastname: Chang
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D002460:Cell Line; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology*; D010087:Oxides; D010944:Plants / Q000032:analysis*; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007546:Isoquinolines; D010087:Oxides