[Acetylpanaxydol and panaxydolchlorohydrin, two new polyenes from Korean ginseng with cytotoxic activity against L1210 cells].
Two new polyines showing good cytotoxic activity against L1210 cells were isolated from Korean ginseng root. These were 3-acetyloxy-9,10-epoxy-heptadec-1-en-4,6-diyne(acet ylpanaxydol, ED50 = 0.52 microgram/ml) and 10-chloro-3,9-dihydroxyheptadec-1-en-4,6-diyne(Panaxydolc hlorohydrin, ED50 = 0.50 microgram/ml).
Ahn
B Z
BZ
Kim
S I
SI
Lee
Y H
YH
D000480:Alkynes / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D053280:Diynes; D007939:Leukemia L1210 / Q000473:pathology*; D005894:Panax / Q000032:analysis*; D010946:Plants, Medicinal; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology
D000480:Alkynes; D000972:Antineoplastic Agents, Phytogenic; D053280:Diynes; C060361:panaxydol chlorohydrin; C060360:3-acetylpanaxydol
Acetylpanaxydol und Panaxydolchlorhydrin, zwei neue, gegen L1210-Zellen cytotoxische Polyine aus Koreanischem Ginseng.