Cytotoxicity of isoquinoline alkaloids and their N-oxides.
A series of 53 isoquinoline alkaloids and their N-oxides have been tested for their cytotoxicity against A-549, HCT-8, KB, P-388, and L-1210 cells. These alkaloids include two tetrahydroprotoberberines, two protoberberines, six aporphines, one morphinandienone, five oxoaporphines, seven phenanthrenes, one spirobenzylisoquinoline N-oxide, nine aporphine N-oxides, seven benzyltetrahydroisoquinoline N-oxides, one benzylisoquinoline N-oxide, one protopine N-oxide, three tetrahydroprotoberberine N-oxides, four pavine N-oxides, and four phenanthrene N-oxides. The results are discussed on the basis of structure-activity relationships.
Wu
Y C
YC
Liou
Y F
YF
Lu
S T
ST
Chen
C H
CH
Chang
J J
JJ
Lee
K H
KH
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D002460:Cell Line; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology*; D010087:Oxides; D010944:Plants / Q000032:analysis*; D013329:Structure-Activity Relationship
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007546:Isoquinolines; D010087:Oxides