Pharmacokinetics of S-[3-chloroprop-2-enyl]glutathione in rats following acute inhalation exposure to 1,3-dichloropropene.
1. An h.p.l.c. method has been developed to quantify the GSH conjugate of 1,3-dichloropropene (DCP). 2. The GSH conjugate of DCP (GSCP) was detected in the blood of rats exposed to DCP by inhalation, and elimination of GSCP from rat blood fitted a one-compartment model. 3. Exposure of rats to 78, 155, or 404 ppm DCP gave an elimination t 1/2 of 17 h, independent of exposure concentration.
Fisher
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Department of Environmental Toxicology, University of California, Davis 95616.
Kilgore
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D000111:Acetylcysteine / Q000031:analogs & derivatives* / Q000097:blood / Q000138:chemical synthesis / Q000493:pharmacokinetics; D000280:Administration, Inhalation; D000498:Allyl Compounds / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D011919:Rats, Inbred Strains
D000498:Allyl Compounds; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; C042828:N-acetyl-S-(3-chloroprop-2-enyl)cysteine; C023891:1,3-dichloro-1-propene; D000111:Acetylcysteine