Variations of prothrombin time, factor VII and protein C with a single daily dose of acenocoumarol. Preliminary results.
In 11 patients on steady anticoagulation with a daily dose of acenocoumarol, prothrombin time, factor VII and protein C were measured 2 and 16 h after the daily intake of acenoumarol. Prothrombin time (expressed as International Normalised Ratio) increases significantly, factor VII and protein C decrease between the two samples. These results suggest that a daily dose of acenoumarol is associated with fluctuation of the anticoagulant effect.
Fiessinger
J N
JN
Service de Médecine Interne et de Pathologie Vasculaire, Hôpital Broussais, Paris, France.
Vitoux
J F
JF
Roncato
M
M
Dellinger
A
A
Dizien
O
O
Aiach
M
M
D000074:Acenocoumarol / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004334:Drug Administration Schedule; D005167:Factor VII / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000378:metabolism*; D011517:Prothrombin Time
D011486:Protein C; D005167:Factor VII; D000074:Acenocoumarol