title: Cytotoxic triterpenes from a Chinese medicine, Goreishi.
abstract: Bioactivity-guided fractionation of the methanol extract of Goreishi (the feces of Trogopterus xanthipes Milne-Edwards) afforded one new and three known cytotoxic triterpenes, namely, 3-O-cis-p-coumaroyltormentic acid, pomolic acid, 2 alpha-hydroxyursolic acid, and jacoumaric acid. In the course of this investigation, six additional compounds having no cytotoxic activity were isolated, namely, maslinic acid, 3-O-trans-p-coumaroylmaslinic acid, ursolic acid, tormentic acid, euscaphic acid, and a new triterpene, 3-O-trans-p-coumaroyltormentic acid. The structures of the new compounds were established on the basis of X-nucleus-proton correlation with fixed evolution time (XCORFE) and other spectroscopic evidence.
authors.forename: A
authors.initials: A
authors.lastname: Numata
authors.forename: P
authors.initials: P
authors.lastname: Yang
authors.forename: C
authors.initials: C
authors.lastname: Takahashi
authors.forename: R
authors.initials: R
authors.lastname: Fujiki
authors.forename: M
authors.initials: M
authors.lastname: Nabae
authors.forename: E
authors.initials: E
authors.lastname: Fujita
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D002470:Cell Survival / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D006801:Humans; D007941:Leukemia P388 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014315:Triterpenes