Thrombolytic activity of defibrotide: a morphometric evaluation in experimental venous thrombosis.
We have studied the morphometric aspects of the thrombolytic activity of Defibrotide in experimental venous thrombosis induced by inserting a collagen-coated nylon thread into the femoral vein of rabbits. 24 hours after thrombus induction Defibrotide decreases the size of thrombi by a factor of 6; stimulation of fibrinolysis and inhibition of platelet and leucocyte recruitment are prominent. Size of the thrombus, extension of the fibrin net and platelet adhesion are also modified by Defibrotide in 7-day-old thrombi where granulation tissue has replaced the original coagulum.
Fumagalli
G
G
Department of Pharmacology, School of Medicine, University of Milan, Italy.
Sala
C
C
Angelaccio
E
E
Lombardo
N
N
Clementi
F
F
D000818:Animals; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D007958:Leukocyte Count; D011089:Polydeoxyribonucleotides / Q000494:pharmacology*; D011817:Rabbits; D013924:Thrombophlebitis / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology
D005343:Fibrinolytic Agents; D011089:Polydeoxyribonucleotides; C036901:defibrotide