Dominantly inherited cleft lip and palate in two families.
Two families with non-syndromic cleft lip and cleft palate are described. The linear pattern of inheritance through several generations is difficult to explain by conventional multifactorial models. The pedigrees strengthen the suggestion that a dominantly inherited mutation exists with a major influence on clefting of the lip and palate alone.
Temple
K
K
Department of Paediatric Genetics, Institute of Child Health, London.
Calvert
M
M
Plint
D
D
Thompson
E
E
Pembrey
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002971:Cleft Lip / Q000150:complications / Q000235:genetics*; D002972:Cleft Palate / Q000150:complications / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010375:Pedigree