title: Wegener's granulomatosis: treatment failure on conventional therapy.
abstract: We report a patient with Wegener's granulomatosis who was initially stabilized, but later relapsed with multiorgan involvement while taking high oral doses of cyclophosphamide (3.7 mg/kg body weight/day) and prednisolone. Remission was achieved with a combined therapy consisting of intermittent intravenous boluses of cyclophosphamide, oral prednisolone, plasmapheresis and oral trimethoprim-sulfamethoxazole. Discussion includes evaluation of the relative beneficial effect of the four treatment constituents.
authors.affiliation: Department of Medicine, University Hospital, Linköping, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Locht
authors.forename: F D
authors.initials: FD
authors.lastname: Lindström
mesh_terms: D000328:Adult; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000628:therapy*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010956:Plasmapheresis; D011239:Prednisolone / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use
chemical_list: D003520:Cyclophosphamide; D011239:Prednisolone; D014295:Trimethoprim; D013420:Sulfamethoxazole