Synthesis of unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones as potential antileukemic agents.
The synthesis of unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones bearing one "mitoxantrone side arm" and another (aminoalkyl)amino moiety has been described. These unsymmetrical anthracene-9,10-diones exhibit cytotoxic activity against L1210 leukemia cells and antitumor activity against P388 leukemia in mice.
Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland.
B
B
Stefanska
M
M
Dzieduszycka
S
S
Martelli
E
E
Borowski
D000818:Animals; D000873:Anthracenes / Q000138:chemical synthesis* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D013329:Structure-Activity Relationship
D000873:Anthracenes; D000970:Antineoplastic Agents