Toxicity of echinulin from Aspergillus chevalieri in rabbits.
Rabbits were injected intraperitoneally with purified echinulin, a product of Aspergillus chevalieri. After 2 h, the rabbits were bled and enzyme analyses were carried out on the supernates of liver homogenates and citrated plasma. Elevated levels of total plasma lactate dehydrogenase, cardiac derived isozyme, glutamic-oxaloacetic and glutamic-pyruvic transaminase activities in animals receiving toxin were observed. These levels were statistically significant compared to the vehicle control. A significant increase in liver lactate dehydrogenase of toxin-treated rabbits was also observed. Light-microscopic examination of lung and liver showed a significant degree of damage. The increase in plasma enzyme levels is indicative of damage to these organs.
Ali
M
M
Department of Biochemistry, Faculty of Science, Kuwait University, Safat.
Mohammed
N
N
Alnaqeeb
M A
MA
Hassan
R A
RA
Ahmad
H S
HS
D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D001230:Aspergillus / Q000032:analysis*; D004121:Dimethyl Sulfoxide / Q000633:toxicity; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects / Q000473:pathology; D009183:Mycotoxins / Q000633:toxicity*; D011817:Rabbits
D000470:Alkaloids; D009183:Mycotoxins; C001132:echinuline; D007770:L-Lactate Dehydrogenase; D004121:Dimethyl Sulfoxide