[Quantitative estimation of the modification of mutagenic effect in experiments on mammals using a regression modification index].
A regressive modification index (RMI = beta M - beta/beta.100) is suggested to quantitatively evaluate modification of the mutagenic effect in experiments on mammals. It is based on the correlation of regressive equation "dose mutagen--effects" coefficients beta M and beta in variants with and without modifier, respectively. Regressive modification indices of various doses of phenobarbital are calculated in experiments on rats with cyclophosphamide and fotrin.
Sycheva
L P
LP
Zhurkov
V S
VS
D000818:Animals; D001388:Aziridines / Q000633:toxicity; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations / Q000187:drug effects; D003520:Cyclophosphamide / Q000633:toxicity; D008322:Mammals / Q000235:genetics*; D009153:Mutagens; D010634:Phenobarbital / Q000633:toxicity; D051381:Rats; D012044:Regression Analysis
D001388:Aziridines; D009153:Mutagens; C007779:fotrin; D003520:Cyclophosphamide; D010634:Phenobarbital
Kolichestvennaia otsenka modifikatsii éffekta mutagenov v opytakh na mlekopitaiushchikh s pomoshch'iu regressionnogo pokazatelia modifikatsii.