[Cerebrospinal fluid parameters in Guillain-Barré polyradiculitis. Importance of barrier disorder and intrathecal immunoglobulin synthesis].
With routine CSF determination of 21 patients with GBS the BBB and the intrathecal IgG synthesis was investigated when calculated CSF/serum albumin ratio and CSF IgG-index respectively. Only in 2 of 21 patients (9.5%) an intrathecal IgG synthesis and in 14 of 21 patients (67%) a BBB damage was found. The BBB was considered as an important pathogenetic factor in GBS. A hypothesis for the development of the albumino-cytological dissociation is presented.
Papen
R
R
Neurologische Klinik, Medizinischen Universität zu Lübeck.
Warecka
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001812:Blood-Brain Barrier; D002556:Cerebrospinal Fluid Proteins / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D011129:Polyradiculoneuropathy / Q000175:diagnosis / Q000276:immunology*
D002556:Cerebrospinal Fluid Proteins; D007136:Immunoglobulins
Parameter des Liquor cerebrospinal is bei Polyradikulitis Guillain-Barré. Bedeutung der Schrankenstörung und der intrathekalen Immunglobulin-Synthese.