7-O-methylhorminone and other cytotoxic diterpene quinones from Lepechinia bullata.
Three cytotoxic diterpene quinones, 6,7-dehydroroyleanone [1], horminone [2], and 7-O-methylhorminone [3], were isolated from an MeOH extract of Lepechinia bullata after bioassay-directed fractionation. Compound 3 is a new compound whose structure was determined through spectroscopic analysis.
Jonathan
L T
LT
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60680.
Che
C T
CT
Pezzuto
J M
JM
Fong
H H
HH
Farnsworth
N R
NR
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010944:Plants / Q000032:analysis*; D011809:Quinones / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D011809:Quinones