PC12 pheochromocytoma and sympathetic nervous system derived trophic factors augment growth of neuroblastoma.
A trophic factor secreted by PC12 rat pheochromocytoma augments growth of C1300 neuroblastoma clonal lines S20, N18 and C46, but does not affect growth of the NIE 115 line. A trophic factor present in newborn sympathetic ganglia has the same biological effect on neuroblastoma cell lines. PC12 cells and sympathetic ganglia are both of neural crest origin; possibly both secrete the same trophic factor.
Chelmicka-Schorr
E
E
Department of Neurology, University of Chicago, IL 60637.
Checinski
M E
ME
Arnason
B G
BG
D000310:Adrenal Gland Neoplasms / Q000378:metabolism; D000818:Animals; D005728:Ganglia, Sympathetic / Q000378:metabolism*; D051379:Mice; D009414:Nerve Growth Factors / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009447:Neuroblastoma / Q000473:pathology*; D010673:Pheochromocytoma / Q000378:metabolism*; D051381:Rats; D011920:Rats, Inbred WF; D014407:Tumor Cells, Cultured / Q000378:metabolism
D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins