[A study by infrared spectroscopy of interactions between the time of disintegration of tablets and liberation of the active principal].
It was shown that the study of the infrared spectra of a drug and of the mixture drug + additives facilitates the preliminary studies for a tablet formulation. Thus, any interaction that may occur or affect the product stability can be detected and located. Furthermore, it was noticed that an interaction between an active ingredient and the various additives may modify the tablet desintegration time, but not necessarily the dissolution rate of this substance.
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Casahoursat
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Pham
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Larrouture
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Heraud
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Etienne
D012995:Solubility; D013055:Spectrophotometry, Infrared; D013607:Tablets
D013607:Tablets
Mise en évidence par spectroscopie infrarouge des interactions affectant le temps de délitement de comprimés et la vitesse de libération du principe actif.