The effect of substituted aminoalkylaminoanthraquinones on eukaryotic cells.
Nine aminoalkylaminoanthraquinones (I-IX) were evaluated for their cytotoxic potency against normal and malignant mammalian cells. The 1.8-di-(aminopropylamino) derivative (VIII) exhibited significant activity against several tumor cell systems and had some selectivity. The toxicity of this compound was also tested in growing chick embryos.
Katzhendler
J
J
Department of Pharmaceutical Chemistry, Hebrew University School of Pharmacy, Jerusalem, Israel.
Bar-Ad
G
G
Haran
M
M
Gean
K F
KF
Tashma
Z
Z
Ringel
I
I
Ramu
A
A
Bachrach
U
U
D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D005347:Fibroblasts / Q000187:drug effects; D005910:Glioma / Q000473:pathology; D007941:Leukemia P388 / Q000473:pathology; D009447:Neuroblastoma / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000880:Anthraquinones; D000970:Antineoplastic Agents