Identification of the ferroxidase centre in ferritin.
Ferroxidase activity in human H-chain ferritin has been studied with the aid of site-directed mutagenesis. A site discovered by X-ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H-chains and is located within the four-helix bundle of the chain fold.
Krebs Institute, Department of Molecular Biology and Biotechnology, The University, Sheffield, England.
D M
DM
Lawson
A
A
Treffry
P J
PJ
Artymiuk
P M
PM
Harrison
S J
SJ
Yewdall
A
A
Luzzago
G
G
Cesareni
S
S
Levi
P
P
Arosio
D000818:Animals; D001665:Binding Sites; D005293:Ferritins / Q000032:analysis* / Q000235:genetics; D006736:Horses; D006801:Humans; D009154:Mutation; D010088:Oxidoreductases / Q000302:isolation & purification*; D011487:Protein Conformation; D051381:Rats; D011994:Recombinant Proteins / Q000032:analysis; D014961:X-Ray Diffraction
D011994:Recombinant Proteins; D005293:Ferritins; D010088:Oxidoreductases; C023100:ferroxidase II