[The behavior of cytoplasmic progesterone receptors in the cycling endometrium and the effect of hormonal contraceptives].
Concentration of cytosolic progesterone receptor (PR) was measured by means of an exchange procedure in the endometria of 80 women. Investigations carried out in 35 normal menstruating females showed a gradual increase of PR during the preovulatory and immediate postovulatory phases, decreasing to the lowest level at the end of the cycle. Measurements in endometrial samples obtained from women on combined hormonal contraceptives demonstrated a significant decline of PR concentration in the periovulatory phase resulting in a flattening of the sinusoid PR concentration curve. The stronger down regulation effect of the preparation containing 1.5 mg of dienogest is due to the higher progestogenic efficacy of dienogest in the respective dosage. We consider the down regulation phenomenon a useful means among others to characterize the progestogenic potency of a steroid.
Klinik für Frauenheilkunde und Geburtshilfe, Bereichs Medizin, Friedrich-Schiller-Universität Jena.
W
W
Carol
R
R
Jäger
P
P
Martin
U
U
Möller
D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage*; D003600:Cytosol / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004717:Endometrium / Q000187:drug effects*; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects*; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D009644:Norgestrel / Q000008:administration & dosage*; D010060:Ovulation / Q000187:drug effects; D011980:Receptors, Progesterone / Q000187:drug effects*
D003277:Contraceptives, Oral, Combined; D011980:Receptors, Progesterone; D009644:Norgestrel; D004997:Ethinyl Estradiol; C023635:dienogest; D009277:Nandrolone; D019304:Ethinyl Estradiol-Norgestrel Combination
Das Verhalten der zytoplasmatischen Progesteronrezeptoren im zyklischen Endometrium und unter der Einwirkung hormonaler Kontrazeptiva.