Monomeric (7S) and polymeric (19S) IgM anti-delta in acute and chronic delta infections.
The chromatographic profiles of IgM anti-delta in 45 acute and 24 chronic delta patients were analyzed by fast protein liquid chromatography (FPLC). Predominance of 19S IgM anti-delta was observed in the sera of 100 percent of coinfected and 62% of superinfected patients. In contrast, 7S IgM anti-delta was predominant in 83% of patients with chronic hepatitis delta. The study of the chromatographic profiles of IgM anti-delta in the development of the disease showed an association between the process of chronic delta-infection and the failure of 7S IgM anti-delta monomers to form 19S pentamers. The results showed that the test for 7S and 19S IgM anti-delta could be useful for differential diagnosis of acute and chronic hepatitis delta infection and for determining the prognosis of acute delta infection.
Vyazov
S O
SO
Department of Viral Hepatitis and Clinical Virology, D.I. Ivanovsky Institute of Virology, Academy of Medical Sciences USSR, Moscow.
Khlopova
I N
IN
Mesyanzhinov
V V
VV
D000208:Acute Disease; D002851:Chromatography, High Pressure Liquid; D002908:Chronic Disease; D003699:Hepatitis D / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism*; D011379:Prognosis; D013997:Time Factors
D007075:Immunoglobulin M; C024242:polymeric IgM