Absence of Y specific DNA sequences in two siblings with 46XX hermaphroditism.
We report two siblings with 46XX hermaphroditism in whom we were unable to show the presence of Y specific DNA sequences using the DNA probes Y-190, GMGY-7, pHY2.1, pDP34, and 27a. We conclude that an autosomal or X chromosome gene mutation is the most likely mechanism of inheritance in this family with 46XX hermaphroditism.
Hospital for Sick Children, London.
J
J
Raine
M E
ME
Robertson
S
S
Malcolm
H
H
Hoey
D B
DB
Grant
D004247:DNA / Q000032:analysis; D015342:DNA Probes; D012734:Disorders of Sex Development / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D012729:Sex Chromosome Aberrations / Q000235:genetics; D014960:X Chromosome; D014998:Y Chromosome
D015342:DNA Probes; D004247:DNA