Experimental bradykinesia in the monkey: speed control impairments after lesion of the substantia nigra.
Unilateral lesions of the substantia nigra were performed on baboons which had been previously trained to perform a visual pointing movement. The resulting motor impairment consisted of an increase in movement duration. This bradykinesia shows as a regular decrease in velocity. A possible change in mode of motor control caused by lesion of the SN is discussed. Partial exclusion of SN might bring about a shift from the feedforward to a feedback mode relaying more heavily on visual cues.
Trouche
E
E
Laboratoire de Neurosciences Fonctionnelles, CNRS, Marseille, France.
Beaubaton
D
D
Viallet
F
F
Apicella
P
P
D000054:Acceleration; D000818:Animals; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D003342:Corpus Striatum / Q000502:physiology; D003463:Cues; D004292:Dominance, Cerebral / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D005246:Feedback; D007537:Isometric Contraction; D009132:Muscles / Q000294:innervation; D009434:Neural Pathways / Q000502:physiology; D009949:Orientation / Q000502:physiology; D010215:Papio; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D011954:Receptors, Dopamine / Q000502:physiology; D013378:Substantia Nigra / Q000502:physiology*
D011954:Receptors, Dopamine; D004298:Dopamine