Evaluation of lasalocid and decoquinate against coccidiosis resulting from natural exposure in weaned dairy calves.
Eighteen female Holstein calves, raised as natural herd additions under conditions typical of a well-managed midwestern United States dairy farm, were used in a natural-exposure study to determine the anticoccidial efficacies of lasalocid and decoquinate. Calves were allotted to 6 treatment blocks of 3 calves each as they were weaned. Within each block, calves were randomly assigned to be given either lasalocid or decoquinate or to remain as a nonmedicated control. Calves were given medication for 90 days and remained separated from other calves for 120 days. Adjusted weight gains were consistently greater in calves that were given medication; however, differences were not statistically significant. Fecal specimens were obtained from calves at weekly intervals during the study. Overall, oocyst shedding was low. During the medication period, quantitative mean fecal shedding of oocysts was reduced eightfold in calves given decoquinate and four-fold in calves given lasalocid, as compared with nonmedicated control calves. During the period following the medication period, calves that had been controls shed fewer oocysts than did calves that had previously been given medication. A pairwise comparison of the proportion of specimens that were oocyst-positive was made to assess qualitative oocyst shedding among treatment groups. During the medication period, qualitative oocyst shedding (all species, Eimeria bovis, E zuernii, species other than E bovis and E zuernii) was greater in controls than in either lasalocid-or decoquinate-treated groups. Like-wise, lasalocid-medicated calves shed oocysts more frequently than did the decoquinate-medicated group. After medication, qualitative findings were reversed. Little diarrhea was noticed in treatment or control calves during the study.(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Veterinary Preventive Medicine, Ohio State University, Columbus 43210.
K H
KH
Hoblet
T P
TP
Charles
R R
RR
Howard
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003667:Decoquinate / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D005260:Female; D006912:Hydroxyquinolines / Q000627:therapeutic use*; D007814:Larva / Q000187:drug effects; D007832:Lasalocid / Q000627:therapeutic use*; D013997:Time Factors; D015430:Weight Gain / Q000187:drug effects
D006912:Hydroxyquinolines; D003667:Decoquinate; D007832:Lasalocid