A study of the mechanisms of chloroquine retinopathy. I. Chloroquine effect on lipid peroxidation of retina.
The influence of chloroquine on lipid peroxidation in rat and rabbit retinas has been studied. Chloroquine retinopathy is not followed by an increase in lipid peroxidation, and the antioxidant ionol does not prevent the drug effect. Chloroquine has an inhibitory action on induced lipid peroxidation.
Helmholtz Institute of Ophthalmology, USSR Academy of Science, Moscow.
T A
TA
Ivanina
N L
NL
Sakina
M N
MN
Lebedeva
V L
VL
Borovyagin
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002738:Chloroquine / Q000633:toxicity*; D004596:Electroretinography; D005404:Fixatives; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000032:analysis; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D013997:Time Factors
D005404:Fixatives; D002084:Butylated Hydroxytoluene; D008315:Malondialdehyde; D002738:Chloroquine