Effect of a natural flavonoid on gastric mucosal barrier.
The effects of 3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-1-benzopyrylium chloride (IdB 1027) on the rat gastric mucosa were evaluated. IdB 1027 administered intragastrically at doses ranging from 100 to 400 mg/kg inhibited the fall in transmucosal potential difference and the increase in H+ back-diffusion induced by acetylsalicylic acid. Moreover, IdB 1027 at doses of 50 and 200 mg/kg by intragastric route increased the gastric bicarbonate secretion. These results suggest that the gastroprotective activity of IdB 1027 is mediated by an increase in the efficiency of gastric mucosal barrier.
Cristoni
A
A
Research and Development Laboratories, Inverni della Beffa, S.p.A., Milan, Italy.
Malandrino
S
S
Magistretti
M J
MJ
D000818:Animals; D000872:Anthocyanins; D001241:Aspirin / Q000378:metabolism; D001578:Benzopyrans / Q000502:physiology*; D001639:Bicarbonates / Q000378:metabolism; D002463:Cell Membrane Permeability; D004058:Diffusion; D005419:Flavonoids / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000872:Anthocyanins; D001578:Benzopyrans; D001639:Bicarbonates; D005419:Flavonoids; C017154:cyanidin; D001241:Aspirin