Co-ordinated expression of the components of iron transport (mycobactin, exochelin and envelope proteins) in Mycobacterium neoaurum.
Mycobacterium neoaurum was grown with a range of iron concentrations from 0.01 to 4.0 micrograms/ml. Synthesis of the extracellular siderophore, exochelin, the intracellular iron storage compound, mycobactin and the iron-repressible envelope proteins were co-ordinately expressed. All three components of the iron transport system were synthesized when low amounts of iron (0.01 to 0.2 micrograms/ml) were added to the medium and were repressed when the iron concentration was increased to 0.5 micrograms/ml and above. These results re-inforce the conclusion that the iron-regulated proteins do fulfil an essential function in iron metabolism.
Sritharan
M
M
Department of Applied Biology, University of Hull, U.K.
Ratledge
C
C
D001426:Bacterial Proteins / Q000096:biosynthesis*; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000096:biosynthesis*; D009161:Mycobacterium / Q000378:metabolism*; D010080:Oxazoles / Q000096:biosynthesis*; D010456:Peptides, Cyclic / Q000096:biosynthesis*
D001426:Bacterial Proteins; D007502:Iron Chelating Agents; D010080:Oxazoles; D010456:Peptides, Cyclic; C010953:exochelins; C018608:mycobactins; D007501:Iron