[Peptidoglycan modification of Staphylococcus aureus P18 strain after use of 6 active antibiotics on the bacterial wall].
Six antibiotics active on the cell-wall were tested against a methicillin resistant Staphylococcus aureus P18 strain at the start of exponential growth rate. The concentration was four-fold the MIC determined in a non-hypersaline liquid medium. The peptidoglycan amino-acid content of the various cell wall samples was determined. An antibiotic-free S. aureus P18 and the methicillin-sensitive Cowan I. S. aureus strain were used a controls. Beta lactam antibiotic treatment, oxacillin and cephalothin, induced an increase of alanine content which suggests that only secondary-transpeptidation did not occur. Similar results were obtained using vancomycin. Amino-acid content was not modified by bacitracin, which is in agreement with the results expected. The results obtained for fosfomycin and cefamandole were not easy to interpret.
Laboratoire de Bactériologie, Faculté de Médecine Alexis-Carrel, Lyon.
F
F
Najioullah
J
J
Freney
G
G
Pellon
H
H
Meugnier
E
E
Dorleac
C
C
Durand
J
J
Fleurette
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002473:Cell Wall / Q000187:drug effects; D004352:Drug Resistance, Microbial; D008712:Methicillin / Q000494:pharmacology; D010457:Peptidoglycan / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D010457:Peptidoglycan; D008712:Methicillin
Modification du peptidoglycane de la souche de Staphylococcus aureus P18 après utilisation de six antibiotiques actifs sur la paroi bactérienne.