Sustained nicotine release comparisons in six inbred rat strains.
The utility of an implantable nicotine reservoir for rats (INRr) in both sexes of several rat strains is described. INRrs with similar nicotine release rates produced higher blood nicotine levels in small female rats compared to larger male Sprague-Dawley rats. Blood nicotine levels declined significantly over a 32-day exposure to the INRr in female Sprague-Dawley rats. In several inbred rat strains (Sprague-Dawley, Fischer, Buffalo, Marshall, Irish, Maudsley), 15-day INRr exposure produced characteristic body weight changes and blood nicotine level changes. Blood nicotine levels in both sexes of various strains are primarily dependent upon body weight characteristics. We conclude that the INRr can be an important tool for the study of the chronic effects of nicotine in rats.
Institute for Neurological Sciences Research College of Pharmacy, University of Texas, Austin 78712.
C K
CK
Erickson
K I
KI
Byers
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004343:Drug Implants; D005260:Female; D008297:Male; D009538:Nicotine / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D051381:Rats; D011912:Rats, Inbred ACI; D011915:Rats, Inbred BUF; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D013045:Species Specificity
D004343:Drug Implants; D009538:Nicotine