Use of topically applied silver sulphadiazine plus cerium nitrate in major burns.
All patients hospitalized between May 1987 and June 1988 suffering from burns covering over 50 per cent of the body surface area were treated by topical application of a cream containing cerium nitrate (0.05 M) and silver sulphadiazine (0.03 M) (CN + SSD). Eleven patients were included in this series, with a mean age of 35 years (range 22-65), a mean total burn size of 78 per cent (range 50-96 per cent) and full skin thickness covering a mean of 48 per cent (range 10-91 per cent). Eight patients survived (73 per cent) (mean age 36 years; mean total burn surface 73 per cent; mean full skin thickness burn surface, 38 per cent). These results are far better than those obtained in our Unit where a survival rate of 34 per cent was obtained in a comparable series of patients treated before 1987. Sixty positive blood cultures were obtained, which included a large variety of organisms with a slight predominance of Staph. aureus, Candida albicans and Ps. aeruginosa. Wound cultures were positive in 72 per cent of swabs and showed a predominance of Ps. aeruginosa (59 per cent of all the strains isolated). Even if CN + SSD appears in this series not to be very efficient in preventing wound colonization and septic complications, it permitted a very high survival rate in the treated patients, taking into account the extreme severity of the injuries. This beneficial effect is probably the consequence of the protective action of the yellow-green eschar formed by CN + SSD.(ABSTRACT TRUNCATED AT 250 WORDS)
Hôpital Cochin, Burn Center, Paris, France.
D
D
Wassermann
M
M
Schlotterer
F
F
Lebreton
J
J
Levy
M C
MC
Guelfi
D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D001458:Bandages; D001830:Body Surface Area; D002056:Burns / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D002563:Cerium / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000517:prevention & control; D012837:Silver Sulfadiazine / Q000008:administration & dosage / Q000627:therapeutic use*; D013411:Sulfadiazine / Q000627:therapeutic use*; D007507:Therapeutic Irrigation
D000891:Anti-Infective Agents, Local; D013411:Sulfadiazine; C032786:cerium nitrate; D002563:Cerium; D012837:Silver Sulfadiazine