The antitumor activity of some palladium(II) complexes with chelating ligands.
A range of palladium(II) complexes with chelating ligands were assayed for their antitumor activity against the tumors P388 and S180 in female mice. The complexes tested were [Pd(L)(ONO2)2] (L = 2,2'-bipyridyl,2-(aminoethyl)pyridine (aep), 2-(aminomethyl)pyridine (amp], [Pd(eth)Cl2] (eth = ethionine) and [Pd(dach)(Meorot)] (dach = trans-1,2-diaminocyclohexane, Meorot = dianion of 3-methylorotic acid). The complexes were administered in water except [Pd(dach)(Meorot)] which was a suspension in klucel. The LD0 values were greater than or equal to 100 mg/kg. None of the complexes were active against the P388 tumor. [Pd(L)ONO2)2] (L = aep, amp) showed marginal activity against S180, while [Pd(dach-)(Meorot)] had an optimal T/C of 267% at dose of 150 mg/kg with 2/10 survivors on day 60.
Laboratoire de Pharmacologie et de Toxicologie Fondamentales du CNRS, Toulouse, France.
F L
FL
Wimmer
S
S
Wimmer
P
P
Castan
S
S
Cros
N
N
Johnson
E
E
Colacio-Rodrigez
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002614:Chelating Agents / Q000494:pharmacology*; D005260:Female; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010165:Palladium / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D002614:Chelating Agents; D010165:Palladium