Identification and some properties of a unique DNA polymerase from cells infected with human B-lymphotropic virus.
A new DNA polymerase and DNase activity were identified from cells infected with human B-lymphotropic herpesvirus (HBLV). DNA polymerase associated with HBLV infection was similar in its sensitivity to inhibition by ppi analogs as other herpesvirus-specific DNA polymerases but was dissimilar in its inhibition by certain nucleoside triphosphates.
Department of Pharmacology, University of North Carolina, Chapel Hill 27599-7365.
A R
AR
Bapat
A J
AJ
Bodner
R C
RC
Ting
Y C
YC
Cheng
D001402:B-Lymphocytes / Q000382:microbiology*; D004259:DNA-Directed DNA Polymerase / Q000302:isolation & purification / Q000502:physiology*; D003851:Deoxyribonucleases / Q000378:metabolism; D006564:Herpesviridae / Q000201:enzymology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D019384:Nucleic Acid Synthesis Inhibitors; D009711:Nucleotides / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D013379:Substrate Specificity
D019384:Nucleic Acid Synthesis Inhibitors; D009711:Nucleotides; D011189:Potassium Chloride; D004259:DNA-Directed DNA Polymerase; D003851:Deoxyribonucleases