[The effect of surface active substances on the barrier properties of the skin].
It was established in experiments conducted on white rats that application to the skin of sulphonol and cintamide--5 for a period of three months result in morphological disorders of the ultrastructural organization of the epidermis, especially of the structure of intercellular contacts. A mixture of these substances produces a more severe noxious effect on the structures. These substances produced also a local effect on the skin microcirculation. The authors propose a scheme for explanation of the mechanism of structural-functional changes of the skin in local applications of surface-active substances.
Arkhipenko
V I
VI
Voloshchenko
O I
OI
Kozlov
V A
VA
Kos
L F
LF
Mudryĭ
I V
IV
D000818:Animals; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000098:blood supply / Q000187:drug effects*; D013501:Surface-Active Agents / Q000633:toxicity*
D013501:Surface-Active Agents
Vliianie poverkhnostno-aktivnykh veshchestv na bar'ernye svoĭstva kozhi.