The increase in [3H]glutamate release associated with long-term potentiation in the dentate gyrus is blocked by commissural stimulation.
Previous findings have indicated that long-term potentiation (LTP) in the perforant path-granule cell synapses is accompanied by an increase in K+-stimulated, calcium-dependent release of [3H]glutamate 45 min after the induction of LTP. Here we report that release of [3H]glutamate is increased at 3 time intervals following induction of LTP, 2.5 min, 45 min and 3 h. Stimulation of the commissural input to the granule cells blocks the induction of LTP and the increase in [3H]glutamate release.
National Institute for Medical Research, London, U.K.
M A
MA
Lynch
M L
ML
Errington
T V
TV
Bliss
D000818:Animals; D002118:Calcium / Q000502:physiology; D004558:Electric Stimulation; D004594:Electrophysiology; D005971:Glutamates / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology*; D008297:Male; D011188:Potassium / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D005971:Glutamates; D011188:Potassium; D002118:Calcium