A novel vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis.
Salivary gland lysates of the sand fly Lutzomyia longipalpis contain a potent vasodilator that aids the fly to feed on the blood of its vertebrate hosts. Chromatographic analysis, antibody reactivity, and data obtained from bioassays of the salivary erythema-inducing factor indicate striking similarity with human calcitonin gene-related peptide. The erythema-inducing factor is, however, at least one order of magnitude more potent than calcitonin gene-related peptide.
Department of Tropical Public Health, Harvard School of Public Health, Boston, MA 02115.
J M
JM
Ribeiro
A
A
Vachereau
G B
GB
Modi
R B
RB
Tesh
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D002116:Calcitonin / Q000494:pharmacology; D015740:Calcitonin Gene-Related Peptide; D002851:Chromatography, High Pressure Liquid; D004175:Diptera; D004890:Erythema; D006801:Humans; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009479:Neuropeptides / Q000494:pharmacology; D011817:Rabbits; D012471:Salivary Proteins and Peptides / Q000302:isolation & purification* / Q000494:pharmacology; D014664:Vasodilation; D014665:Vasodilator Agents
D009479:Neuropeptides; D012471:Salivary Proteins and Peptides; D014665:Vasodilator Agents; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide