Bioactive compounds from the root of Myrsine africana.
Bioactivity-directed fractionation of the EtOH extract of the roots of Myrsine africana, using lethality to brine shrimp, led to the isolation and identification of emodin and 2-hydroxychrysophanol as cytotoxic components, the latter being a new natural product. Nepodin and 5-methoxy-7-hydroxyphthalide were also isolated but were not significantly cytotoxic.
Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
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McLaughlin
D000880:Anthraquinones / Q000302:isolation & purification*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D004642:Emodin / Q000031:analogs & derivatives / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D010944:Plants / Q000032:analysis*; D014407:Tumor Cells, Cultured
D000880:Anthraquinones; D000972:Antineoplastic Agents, Phytogenic; C061026:2-hydroxychrysophanol; D004642:Emodin