Lack of acute effects of methotrexate on rat parotid salivary gland function.
Like other cytotoxic drugs, methotrexate (MTX) produces adverse reactions in oral tissues. Parotid gland function was examined, in vivo and in vitro, 18 h after MTX administration (15 mg/kg, i.p.). No salivary effects could be detected consistently. In addition, the integrity of the oral mucosa remained intact. Thus, at this dose, MTX does not exert an acute cytotoxic effect either on a rapidly replicating oral tissue like the mucosa, or on tissue with a slow turnover rate like the parotid.
National Institute of Dental Research Bethesda, MD 20892.
A
A
Wolff
J E
JE
Moreira
Y
Y
Marmary
P C
PC
Fox
D000818:Animals; D008297:Male; D008727:Methotrexate / Q000633:toxicity*; D009061:Mouth Mucosa / Q000187:drug effects; D010306:Parotid Gland / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000032:analysis
D008727:Methotrexate