Excretion of amino acids by 1,2,4-triazole-3-alanine-resistant mutants of Methanococcus voltae.
In contrast to wild-type cells, it was found that triazole-alanine-resistant mutants of Methanococcus voltae excreted histidine, proline, phenylalanine, and tyrosine in various combinations. These results suggest that a form of general amino acid biosynthetic control may operate in this methanogen. We also show that wild-type M. voltae excretes methionine.
Sment
K A
KA
Department of Microbiology, University of Illinois, Urbana 61801.
Konisky
J
J
D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000596:Amino Acids / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D019605:Euryarchaeota / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D006639:Histidine / Q000378:metabolism; D008715:Methionine / Q000378:metabolism; D009154:Mutation; D010649:Phenylalanine / Q000378:metabolism; D011392:Proline / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism
D000596:Amino Acids; C003633:triazolealanine; D014443:Tyrosine; D010649:Phenylalanine; D006639:Histidine; D011392:Proline; D008715:Methionine; D000409:Alanine