Ceftriaxone diffusion from blood to aqueous humour in man.
Ceftriaxone penetrates into the aqueous humour in man. The interaction of indomethacin on the disposition of ceftriaxone appeared to be time-dependent. Indomethacin delayed ceftriaxone penetration into, but enhanced its persistence in, the aqueous humour, permitting a period of antibioprophylaxis covering the required time for surgical treatment.
Department of Anaesthesiology, Fondation Rothschild, Paris, France.
D
D
Gobeaux
L
L
Ambart
J L
JL
Couderc
P H
PH
Renard
B
B
De Charnace
F
F
Lokiec
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000378:metabolism*; D002443:Ceftriaxone / Q000097:blood / Q000493:pharmacokinetics*; D004058:Diffusion; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged
D002443:Ceftriaxone; D007213:Indomethacin