Intracellular free calcium concentration in lymphocytes of patients with muscular dystrophies.
Intracellular free calcium concentration [( Ca2+]i) of human peripheral blood lymphocytes was determined by fluorescence spectroscopic measurements with quin2 in patients with different types of muscular dystrophy and in controls. The [Ca2+]i level in lymphocytes showed a significant increase in adult type (facioscapulohumeral and limb-girdle) muscular dystrophies, while it showed a decrease in Duchenne dystrophy as compared to the values of age- and sex-matched controls. The data obtained suggest an alteration in the effectiveness of the calcium pump in lymphocytes and may represent a sign of generalized membrane damage in these hereditary muscle diseases.
Department of Neurology and Psychiatry, University Medical School of Debrecen, Hungary.
F
F
Mechler
M
M
Molnár
M
M
Balázs
J
J
Matkó
D000328:Adult; D000367:Age Factors; D002118:Calcium / Q000097:blood*; D002648:Child; D003593:Cytoplasm / Q000032:analysis*; D006801:Humans; D008214:Lymphocytes / Q000032:analysis*; D008297:Male; D009136:Muscular Dystrophies / Q000097:blood* / Q000145:classification / Q000503:physiopathology; D013050:Spectrometry, Fluorescence
D002118:Calcium