The role of macrophages in experimental Campylobacter-infections of mice in Lagos, Nigeria.
The role of macrophages in experimental campylobacteriosis was studied in mice whose macrophages had been blocked using colloidal carbon particles as the blockading agent. Two sets of mice received 0.4 ml intraperitoneally and 0.4 ml intravenously of colloidal carbon, respectively, and each set was then inoculated with a clinical isolate of Campylobacter jejuni intraperitoneally. The treatment resulted in a lethality of 66.6% in mice given colloidal carbon intraperitoneally and 58.0% in mice given colloidal carbon intravenously within the first three days post infection. The control groups (mice injected only with C. jejuni) had a lethality of 16.6% (p less than 0.05). Mice receiving only colloidal carbon showed no lethality. These results suggest that the activities of macrophages as scavenger cells are important factors in the defence mechanism of mice against experimental campylobacteriosis.
Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Nigeria.
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D000818:Animals; D002169:Campylobacter Infections / Q000276:immunology*; D002168:Campylobacter fetus; D002244:Carbon; D003102:Colloids; D008264:Macrophages / Q000276:immunology*; D051379:Mice
D003102:Colloids; D002244:Carbon