Effect of capsaicin on triglyceride accumulation & secretion in ethanol fed rats.
Rats fed capsaicin (0.15, 1.5 and 15 mg%) containing diets were able to counter by about 30 per cent of the hepatic lipid accumulation caused by a single dose administration of ethanol (6 g/kg body weight). The rate of triglyceride secretion in capsaicin fed animals from liver to plasma was also elevated as judged by Triton WR-1339 induced hypertriglyceridemia. The results suggest a possible mechanism by which capsaicin counters ethanol induced hepatic lipid accumulation in rats.
Sambaiah
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Satyanarayana
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D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism*
D014280:Triglycerides; D000431:Ethanol; D002211:Capsaicin