Effects of flunitrazepam and triazolam in man: are they influenced by the time of ingestion?
Five healthy young volunteers were given flunitrazepam 1 mg, triazolam 0.25 mg or placebo at 2 a.m. or 9 a.m. in a double blind, cross-over study. The aim was to investigate the cyclic variations mainly in residual effects of the drugs, but also in sleep onset latency and pharmacokinetics. The study suggested cyclic variations in mood, psychometric tests and in sleep onset latency.
Department of Surgery, Ullevaal Hospital, Oslo, Norway.
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E
Wickstrøm
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Bredesen
J
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Gordeladze
D000328:Adult; D005260:Female; D005445:Flunitrazepam / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D008297:Male; D012890:Sleep / Q000187:drug effects; D013997:Time Factors; D014229:Triazolam / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
D014229:Triazolam; D005445:Flunitrazepam