Mephenytoin and sparteine oxidation: genetic polymorphisms in Denmark.
The oxidation of mephenytoin was polymorphic in 358 healthy Danish volunteers. The ratio between the chromatographic peak areas of (S)- and (R)-mephenytoin (S/R) in 12 h urine was less than or equal to 0.48 in 349 extensive metabolizers (EM) and greater than or equal to 1 in 9 (2.5%) poor metabolizers (PM). Concomitant intake of mephenytoin and sparteine and subsequent assay by gas chromatography had no influence on the test results (mephenytoin S/R ratio or sparteine metabolic ratio). Among ten parents and seven siblings to six unrelated PM of mephenytoin only one (1/17 = 5.9%) was a PM. The pedigrees were compatible with an autosomal recessive mode of inheritance.
Department of Clinical Pharmacology, Odense University, Denmark.
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Drøhse
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Bathum
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Brøsen
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D000293:Adolescent; D000328:Adult; D002849:Chromatography, Gas; D003718:Denmark; D005260:Female; D006801:Humans; D006827:Hydantoins / Q000378:metabolism*; D008297:Male; D008617:Mephenytoin / Q000378:metabolism* / Q000493:pharmacokinetics; D008875:Middle Aged; D010084:Oxidation-Reduction; D010641:Phenotype; D011110:Polymorphism, Genetic; D013034:Sparteine / Q000378:metabolism* / Q000493:pharmacokinetics
D006827:Hydantoins; D013034:Sparteine; D008617:Mephenytoin