[Activation of the complement system in dilated cardiomyopathy].
The levels of anaphylatoxins (C3a, C5a) in blood, components of complements C3 and C4, antibodies to cardiolipin, IgG, IgA, IgM, IgE and circulating immune complexes were measured in 21 patients with dilated and hypertrophic cardiomyopathy (DCMP and HCMP) and in 11 donors. The mean level of C3a in DCMP patients (572 +/- 55 ng/ml) was significantly higher than in HCMP patients (344 +/- 30 ng/ml) and in donors (294 +/- 43 ng/ml) (p less than 0.001). On comparison of C5a concentrations in DCMP patients (2.2 +/- 0.52 ng/ml), HCMP patients (3.3 +/- 1.2 ng/ml) and in donors (1.6 +/- 0.82 ng/ml) no significant differences were found (p greater than 0.05). It has been established that in the group of DCMP patients with thromboembolic complications, the concentrations of C3a (736 +/- 95 ng/ml) were significantly higher than in those without such complications (334 +/- 14 ng/ml) (p less than 0.001). The data obtained permit discussing the role of anaphylatoxins in the development of thromboembolic complications in DCMP patients.
Nasonov
E L
EL
Samsonov
M Iu
MIu
Aleksandrova
L Z
LZ
Masenko
V P
VP
Ovtrakht
N V
NV
D000293:Adolescent; D000328:Adult; D000706:Anaphylatoxins / Q000276:immunology; D002311:Cardiomyopathy, Dilated / Q000276:immunology*; D002312:Cardiomyopathy, Hypertrophic / Q000276:immunology; D003167:Complement Activation; D006801:Humans; D008875:Middle Aged
D000706:Anaphylatoxins
Aktivatsiia sistemy komplementa pri dilatatsionnoĭ kardiomiopatii.