Drosophila mutants with progressive atrophy in dorsal longitudinal muscles.
We have characterized six chemically induced mutations of the Drosophila dlm-defective (d l m d) gene. The mutants are flightless, but they have an otherwise normal appearance. By electron microscopic examination, a focal atrophy was found in their dorsal longitudinal muscle (DLM) fibers, but no abnormalities in nerve conduction or synaptic transmission were detected by electrophysiological tests. The nerve-evoked muscle spike also seemed to be normal, except that the resting potential of DLM in mutant flies was lower and their membrane excitability was higher than those in the wild type flies. The possible causes of the DLM degeneration in this strain are discussed.
Institute of Genetics, Fudan University, Shanghai, China.
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Wang
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Keng
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Hsu
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Tan
D000483:Alleles; D000818:Animals; D001284:Atrophy; D002874:Chromosome Mapping; D004330:Drosophila / Q000235:genetics* / Q000502:physiology; D004558:Electric Stimulation; D008040:Genetic Linkage; D008854:Microscopy, Electron; D009132:Muscles / Q000502:physiology* / Q000648:ultrastructure; D009154:Mutation; D009424:Nervous System Physiological Phenomena