Antinociceptive properties of lysozyme fragments.
The in vitro digestion of hen egg white lysozyme with artificial gastric juice gave a complex mixture of peptides, from which a peptide corresponding to the aminoacid sequence 39-53 was isolated. Its further hydrolysis with artificial enteric juice gave two smaller fragments having the aminoacid sequence 39-45 and 46-53 respectively. These products, like lysozyme, showed antinociceptive activity in rats against foot hyperalgesia induced by a subplantar injection of brewer's yeast.
T
T
Bruzzese
A
A
Cedro
C A
CA
Fanciano
L
L
Basilico
A
A
Angeli
F
F
Ferrari
G
G
Patrini
G
G
Giagnoni
D000700:Analgesics; D000818:Animals; D008297:Male; D009113:Muramidase / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D010446:Peptide Fragments; D009113:Muramidase