Fate and residues of trenbolone acetate in edible tissues from sheep amd calves implanted with tritium-labeled trenbolone acetate.
In order to study the fate and residues of trenbolone acetate in edible tissues, two groups of six animals from two ruminant species (ewes and calves) were implanted with [3H]trenbolone acetate. The distribution of extractable radioactive residues was measured in liver, kidney and muscle. We found that the largest proportion of residues was not extractable and thus was considered as covalently bound residues. The proportion of the main extractable metabolites (17 alpha-trenbolone, trendione, 17 beta-trenbolone) was measured. The evaluation of the distribution of trenbolone acetate metabolites directly soluble in water showed that unknown metabolite(s) were predominant. The covalent binding to nucleic acids was measured. It was so low that it was not detectable. The results are discussed in light of the data presented in the scientific report on anabolic agents in animal production from the European scientific working group.
University of Liege, Belgium.
P
P
Evrard
G
G
Maghuin-Rogister
A G
AG
Rico
D045930:Anabolic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D002417:Cattle / Q000378:metabolism*; D004343:Drug Implants; D004350:Drug Residues / Q000032:analysis; D004963:Estrenes / Q000493:pharmacokinetics*; D005260:Female; D008460:Meat / Q000032:analysis*; D012756:Sheep / Q000378:metabolism*; D013997:Time Factors; D014204:Trenbolone Acetate / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D014316:Tritium
D045930:Anabolic Agents; D004343:Drug Implants; D004963:Estrenes; D014316:Tritium; D014204:Trenbolone Acetate