Proliferative fasciitis: ultrastructure and histogenesis.
The ultrastructure was studied of 2 cases of proliferative fasciitis (PF) which affected the fascia and subcutaneous fat. Two basic cell types were observed in the lesions: fibroblast-like, and giant cells. The fibroblast-like cells had myofibroblastic ultrastructural characteristics. The giant cells showed a well-developed, rough endoplasmic reticulum, irregularly distributed filaments and clear lipid droplets in their cytoplasms. Ultrastructurally, the giant cells seemed to belong to a cellular line capable of synthesizing ground substances and extracellular fibers, but with a modified phenotype. A consistent feature was the presence of nodular aggregates of numerous proliferating perivascular cells. Transitional forms between perivascular, fibroblast-like, and giant cells were observed. Our hypothesis is that perivascular cells (activated pericytes) are the source of the fibroblast-like and giant cells in proliferative fasciitis.
Department of Pathology, La Laguna University, Canary Island, Spain.
L
L
Diaz-Flores
A I
AI
Martin Herrera
R
R
Garcia Montelongo
R
R
Gutierrez Garcia
D005205:Fascia / Q000473:pathology / Q000648:ultrastructure*; D005208:Fasciitis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged