[Effects of combined therapy with irradiation, cisplatin and vindesine in lymph node recurrence of esophageal cancer].
The effects of combined therapy with irradiation, cisplatin and vindesine for lymph node recurrence of esophageal cancer was studied. The subjects were 95 patients with lymph node recurrence, who were divided into the following four treatment groups: Group I: Radiotherapy alone (R) (n = 31); Group II: cisplatin (CDDP) alone (n = 18); Group III: R + CDDP(n = 9); Group IV: R + CDDP + VDS (n = 10). The response rate (CR + PR) of Groups III and IV was 66.7% and 100%, respectively, which was significantly more favorable than 11.1% of Group II. The survival duration after recurrence was prolonged in the order of Group IV, Group III, Group II and Group I. In conclusion, combination therapy using R, CDDP and VDS will be effective for lymph node recurrence of esophageal cancer.
Second Dept. of Surgery, School of Medicine, Chiba University.
K
K
Okuyama
S
S
Onoda
T
T
Kouzu
N
N
Tohnosu
Y
Y
Koide
T
T
Awano
H
H
Matubara
T
T
Sano
H
H
Kinosita
H
H
Nakaichi
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D008207:Lymphatic Metastasis / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011379:Prognosis; D014751:Vindesine / Q000008:administration & dosage
D002945:Cisplatin; D014751:Vindesine