The influence of buflomedil on blood viscosity parameters in insulin-dependent diabetic patients: a preliminary study.
We have evaluated the effect of buflomedil on blood viscosity in insulin-dependent diabetic patients. At the start several rheological parameters were disturbed in these patients. After 3 months of treatment with buflomedil, blood viscosity was significantly decreased at low (P less than 0.05) and high (P less than 0.05) shear rates. The decrease in whole blood viscosity was due to a significant decrease (P less than 0.05) in plasma viscosity, which could be attributed to a significant (P less than 0.01) fall in plasma fibrinogen. There was no effect on erythrocyte deformability as assessed by erythrocyte viscosity measurements. We conclude that treatment with buflomedil improved but did not normalize some rheological parameters in insulin-dependent diabetic patients.
Department of Medicine, University of Antwerp, Wilrijk, Belgium.
K
K
Van Acker
E
E
Rillaerts
I
I
De Leeuw
D000293:Adolescent; D000328:Adult; D001809:Blood Viscosity / Q000187:drug effects*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006400:Hematocrit; D006801:Humans; D008297:Male; D011759:Pyrrolidines / Q000494:pharmacology*
D011759:Pyrrolidines; D005340:Fibrinogen; C010651:buflomedil