Incompatibility of contrast agents with intravascular medications. Work in progress.
In vitro and in vivo precipitation of iodinated contrast agents when ioxaglate and papaverine are given together has been reported. To verify these reports and to investigate other medications not previously tested, the authors analyzed mixtures of contrast agents and medications in vitro with a light spectrophotometer and observed them for visible precipitates for up to 120 minutes. Previously reported incompatibilities between ionic or low-osmolality contrast media and medications were verified, and several new incompatibilities were discovered. No incompatibilities were found when the drugs tested were mixed with the new nonionic contrast media.
Irving
H D
HD
Department of Medical Imaging, University Hospital, Saskatoon, Sask, Canada.
Burbridge
B E
BE
D011232:Chemical Precipitation; D002927:Cimetidine / Q000008:administration & dosage; D003287:Contrast Media / Q000008:administration & dosage; D003974:Diatrizoate Meglumine / Q000008:administration & dosage; D004155:Diphenhydramine / Q000008:administration & dosage; D004344:Drug Incompatibility; D005839:Gentamicins / Q000008:administration & dosage; D066298:In Vitro Techniques; D007262:Infusions, Intravenous; D007472:Iohexol / Q000008:administration & dosage; D007479:Iopamidol / Q000008:administration & dosage; D007482:Iothalamate Meglumine / Q000008:administration & dosage; D007485:Ioxaglic Acid / Q000008:administration & dosage; D010208:Papaverine / Q000008:administration & dosage; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011479:Protamines / Q000008:administration & dosage; D013053:Spectrophotometry
D003287:Contrast Media; D005839:Gentamicins; D004364:Pharmaceutical Preparations; D011479:Protamines; D003974:Diatrizoate Meglumine; D007472:Iohexol; D002927:Cimetidine; D004155:Diphenhydramine; D010208:Papaverine; D007479:Iopamidol; D007482:Iothalamate Meglumine; D007485:Ioxaglic Acid