Synthesis and biological activity of dibenz[c,e]azepines.
Synthesis and pharmacological screening of 68 dibenz[c,e]azepines are described. All were inactive as antidepressant agents, but two compounds showed good anticonvulsant activity. The structure-activity relationships of this class of compounds are discussed.
Aboul-Enein
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HY
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Ibrahim
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SE
Khalifa
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M
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D003984:Dibenzazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D004597:Electroshock; D005260:Female; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D004856:Postural Balance / Q000187:drug effects
D000927:Anticonvulsants; D003984:Dibenzazepines; D010433:Pentylenetetrazole