Antimalarial efficacy of arteether against multiple drug resistant strain of Plasmodium yoelii nigeriensis.
New quick-acting blood schizontocides are needed to contain the spread of multiple drug resistant strains of P. falciparum and for the treatment of the cerebral malaria cases. A multiple drug resistant strain of P. yoelii nigeriensis resistant to mefloquine (128 mg/kg x 6 days), quinine (300 mg/kg x 7 days) and chloroquine (64 mg/kg x 8 days) was found to be completely susceptible to arteether (a 30:70 mixture of alpha and beta enantiomers) and a dose of 5 mg/kg x 3 days by i.m. route was curative in Swiss mice. Artemisinin at 50 mg/kg x 7 days had only suppressive action against this strain.
Division of Microbiology, Central Drug Research Institute, Lucknow, India.
G P
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Dutta
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Bajpai
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Vishwakarma
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins; D004351:Drug Resistance; D051379:Mice; D010967:Plasmodium yoelii / Q000187:drug effects*; D012717:Sesquiterpenes / Q000494:pharmacology*
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin; C055141:artemotil