Treatment with anti-L3T4 (CD4) monoclonal antibody reduces the inflammatory response in toxoplasmic encephalitis.
Toxoplasma gondii is an important cause of disease of the central nervous system in patients with AIDS. Among the variety of immunologic disorders encountered by AIDS patients is a depletion of CD4+ subpopulation of lymphocytes. In order to determine the role of this population of T lymphocytes in the generation of toxoplasmic encephalitis, mice chronically infected with T. gondii were treated with mAb GK1.5 directed against the cell surface glycoprotein L3T4 (CD4) of T lymphocytes. Histopathologic sections of brains of control and treated animals were examined at regular intervals during and after completion of treatment. The results demonstrated significantly less inflammation in brains of mice during treatment with GK1.5 mAb. In addition, recrudescence of the inflammatory process occurred after discontinuation of treatment. Similar results were observed in experiments in which different strains of mice and T. gondii were used.
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, CA 94301.
D M
DM
Israelski
F G
FG
Araujo
F K
FK
Conley
Y
Y
Suzuki
S
S
Sharma
J S
JS
Remington
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D001921:Brain / Q000473:pathology; D004660:Encephalitis / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D005260:Female; D006968:Hypersensitivity, Delayed / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D051381:Rats; D014124:Toxoplasmosis, Animal / Q000276:immunology / Q000473:pathology* / Q000628:therapy
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte