Crystallization of human leukocyte elastase with its inhibitor Pro44-eglin c.
Human leukocyte elastase has been crystallized in complex with recombinant Pro44-eglin c in the orthorhombic space group P2(1)2(1)2(1). The cell constants are a = 126.1 A, b = 127.8 A, c = 69.4 A, alpha = beta = gamma = 90 degrees. The crystals diffract to at least 2.5 A resolution and are suitable for crystallographic structure analysis.
Pharmaceuticals Division, Ciba Geigy Ltd, Basle, Switzerland.
D W
DW
Heinz
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M
Liersch
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Grütter
D003460:Crystallization; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D011506:Proteins; D015843:Serpins; D014961:X-Ray Diffraction
D011506:Proteins; D015843:Serpins; C060642:eglin c, Pro 44; D010196:Pancreatic Elastase