Do steroid hormones influence the concentration of PGF2 alpha receptors of the uterine muscles?
Uterine contractions are largely regulated by steroid hormones. The receptors which are important from the point of view of uterine contractions (such as oxytocin, alpha- and beta-adrenergics) are also influenced by steroid hormones. In this paper the regulation by steroids of PG2 alpha receptors was studied in vivo. Due to ovariectomy, the concentration of PG2 alpha decreased significantly in rats without a change in affinity. As a result of in vivo progesterone treatment, the PG2 alpha receptor concentration decreased to its third as compared to that of the ovariectomized control also without a change in affinity. PG2 alpha receptor concentration was not changed by in vivo estrogen treatment in comparison to that of the ovariectomized control but a high-affinity, low-capacity binding-site appeared. Our experiments revealed the in vivo regulation by steroid hormones of the PGW2 alpha receptors of the rat myometrium.
2nd Department of Obstetrics and Gynaecology, Semmelweis University Medical School, Budapest, Hungary.
F
F
Lintner
F
F
Hertelendy
B
B
Zsolnay
D000818:Animals; D015237:Dinoprost / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D010052:Ovariectomy; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011982:Receptors, Prostaglandin / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
D011982:Receptors, Prostaglandin; C034671:prostaglandin F2alpha receptor; D011374:Progesterone; D004958:Estradiol; D015237:Dinoprost