Antiproliferative effects of 4',5'-unsaturated adenine nucleosides on leukemia L1210 cells in vitro.
Several 4',5'-unsaturated adenine nucleosides were shown to have antiproliferative activity against L1210 leukemia cells in vitro. The active nucleosides were cytotoxic to the L1210 cells as demonstrated by Trypan Blue uptake. The cytotoxicity was not induced by alterations in the ribonucleoside and deoxyribonucleoside triphosphate levels of the L1210 cells.
Sheid
B
B
Department of Pharmacology, State University of New York, Brooklyn 11203.
Lerner
L M
LM
Gaetjens
E
E
D000227:Adenine Nucleotides / Q000032:analysis; D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents; D002455:Cell Division / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D003597:Cytosine Nucleotides / Q000032:analysis; D006150:Guanine Nucleotides / Q000032:analysis; D007939:Leukemia L1210 / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014500:Uracil Nucleotides / Q000032:analysis
D000227:Adenine Nucleotides; D000970:Antineoplastic Agents; D003597:Cytosine Nucleotides; D006150:Guanine Nucleotides; D014500:Uracil Nucleotides; D000241:Adenosine