Acrylamide and thiamine.
Acrylamide administration to rats caused clear alteration of blood thiamine content, which appeared to reflect suppressed intake and/or utilization of the vitamin in the body. Decreased utilization of thiamine does not seem to be induced by decreased binding of thiamine pyrophosphate (TPP) and apotransketolase, because acrylamide did not affect the Km of TPP for transketolase activity.
Department of Environmental Toxicology, University of Occupational and Environmental Health, Kitakyushu, Japan.
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D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013831:Thiamine / Q000378:metabolism* / Q000493:pharmacokinetics; D013835:Thiamine Pyrophosphate / Q000378:metabolism; D014174:Transketolase / Q000378:metabolism
D000178:Acrylamides; D014174:Transketolase; D013835:Thiamine Pyrophosphate; D013831:Thiamine