Normal values for quantitative parameters for evaluation of mucociliary clearance in lungs.
Twenty-eight normal male subjects (13 nonsmokers and 15 smokers, 25 to 76 years of age) inhaled ultrasonically generated 99mTc-tagged human serum albumin aerosol (mass median diameter: 1.93 microns with geometric standard deviation of 1.52) and radioactivity from the thorax was measured continuously from anteriorly in 10 sec frame mode for 90 to 120 min to evaluate mucociliary clearance function in the lungs. Normal values for lung retention ratio (LRR), airway deposition ratio (ADR), airway retention ratio (ARR), airway clearance efficiency (ACE), alveolar deposition ratio (ALDR), and disappearance rate of radioactivity from the ciliated airways (DR) were presented. ALDR was significantly larger in nonsmokers than in smokers. LRR and ARR were significantly smaller and ACE, significantly larger in smokers at any time intervals than in nonsmokers, while ADR and DR were larger in smokers only in the initial 30 min following radioaerosol inhalation was completed. Thereafter there was little difference in ADR and DR between normal smokers and nonsmokers.
Isawa
T
T
Department of Medicine, Tohoku University, Sendai, Japan.
Teshima
T
T
Hirano
T
T
Anazawa
Y
Y
Miki
M
M
Konno
K
K
Motomiya
M
M
D000328:Adult; D000368:Aged; D006801:Humans; D008168:Lung / Q000502:physiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance; D012016:Reference Values; D012907:Smoking / Q000503:physiopathology*; D013997:Time Factors