[The effectiveness of intratracheal antibiotic administration. Clinical, microbiologic and pharmacologic results].
In 199 artificially ventilated patients of an internal intensive care unit clinical, bacteriological and pharmacological effects of endotracheally administered gentamicin were investigated. The dose schedule was 2-4 x 40 mg gentamicin/day. The incidence of secondary achieved pneumonia was reduced from 70% to 18%. The endotracheal colonization of pathogenic microorganisms reached 29.6% concerning bacterial microorganisms and 61% concerning fungi, 51.8% of all specimen were sterile. During 4 years of investigation there were found 19 secondary resistances of different bacteria, 12 persisted. Serum concentrations of gentamicin under endotracheal administration of 40 mg in 6-h-intervals didn't reach therapeutic values. In case of renal disorder the dose interval should be prolonged to twelve hours.
Kleinschmidt
R
R
Medizinische Klinik, Universität Bonn.
Rommelsheim
K
K
Exner
M
M
Vogel
F
F
D000328:Adult; D000368:Aged; D001419:Bacteria / Q000302:isolation & purification; D001996:Bronchopneumonia / Q000382:microbiology / Q000517:prevention & control*; D003422:Critical Care; D003428:Cross Infection / Q000517:prevention & control*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000628:therapy; D012121:Respiration, Artificial; D012307:Risk Factors; D014132:Trachea / Q000382:microbiology
D005839:Gentamicins
Die Wirksamkeit intratrachealer Antibiotikaapplikation. Klinische, mikrobiologische und pharmakologische Ergebnisse.