Study of the strontium response in isolated rat aorta.
We have studied the effects of the cumulative application of Sr2+ in isolated rat aorta in a normal and in a Ca2+-free solution containing EDTA 1 mM. Sr2+ induced a concentration-dependent contraction which was reduced by verapamil (5 X 10(-6) and 10(-7) M) and lanthanum (1 and 2 mM). Sr2+ also induced a contraction in K+-depolarized medium. In aorta strips depleted of Ca2+ by several applications of noradrenaline (10(-6) M), Sr2+ induced a dose-response contraction in a Ca2+-free solution. These findings suggest that the influx of external Ca2+ is only partly responsible for the Sr2+-induced contraction and that another intracellular mechanism is involved in the response.
Departamento de Farmacología y Farmacotecnia, Facultad de Farmacia, Universidad de Valencia, Spain.
A
A
Barreda
E
E
Anselmi
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001464:Barium / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D066298:In Vitro Techniques; D007811:Lanthanum / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013324:Strontium / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology
D001464:Barium; D007811:Lanthanum; D014700:Verapamil; D011188:Potassium; D002118:Calcium; D009638:Norepinephrine; D013324:Strontium