[Biotransformation in patients following Depressan-induced hepatitis].
In 17 patients who more than 1 year ago had suffered from a dihydralazine induced hepatitis the biotransformation velocity was investigated and compared with a healthy control group. 15 out of the 17 patients and 5 out of the 10 volunteers are slow acetylators. All slow acetylators eliminate sulfamethazine more slowly than rapid acetylators.--The elimination of caffeine and metamizol--test substances for oxidative biotransformation reactions--was retarded in patients after dihydralazine induced hepatitis in comparison to control persons. Slow acetylators have to be controlled carefully because of their higher risk of dihydralazine induced drug hepatitis.
Institut für Klinische Pharmakologie, Friedrich-Schiller-Universität Jena.
A
A
Hoffmann
M
M
Reinhardt
C
C
Rechenbach
L
L
Henschel
D
D
Jorke
D000328:Adult; D000368:Aged; D001711:Biotransformation; D002110:Caffeine / Q000493:pharmacokinetics*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood*; D004078:Dihydralazine / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D013418:Sulfamethazine / Q000493:pharmacokinetics*
D006830:Hydralazine; D002110:Caffeine; D013418:Sulfamethazine; D004078:Dihydralazine
Biotransformation bei Patienten nach Depressan-Hepatitis.