Use of Old World monkeys for acquired immunodeficiency syndrome research.
Mangabeys, macaques, and baboons persistently infected with human immunodeficiency virus (HIV)-2 NIH-DZ demonstrated no signs of immunodeficiency disease after 6-11 months following seroconversion. Thus Old World monkeys provide an animal model to investigate the effects of passive immunization (anti-HIV-2 antibodies) on HIV infection in primates.
Laboratoire de Physiologie Cellulaire, Université Pierre et Marie Curie, Paris, France.
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Nicol
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Messinger
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Dubouch
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Bernard
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Desportes
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Jouffre
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Snart
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Nara
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Gallo
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Zagury
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology* / Q000517:prevention & control; D000818:Animals; D015153:Blotting, Western; D002520:Cercopithecidae; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D015483:HIV Antibodies / Q000032:analysis; D015488:HIV Antigens / Q000032:analysis; D015498:HIV-2 / Q000276:immunology / Q000302:isolation & purification* / Q000648:ultrastructure; D007116:Immunization, Passive; D008253:Macaca mulatta; D010215:Papio
D015483:HIV Antibodies; D015488:HIV Antigens