Amino acid losses during haemofiltration.
Amino acid losses were measured daily in a non-septic patient who was continuously haemofiltered for 7 days at an ultrafiltration rate of 1,000 ml/h and then for a further 7 days at 500 ml/h. During this period she received an infusion of 9 g nitrogen each day. At the higher ultrafiltration rate the mean amino acid loss was 7.9 g/24 h (SEM 0.3 g) and at the lower rate, 2.4 g/24 h (SEM 0.2 g). The losses of amino acids to the ultrafiltrate depended upon the rate of ultrafiltration and upon the free serum amino acid values (r = 0.93, p less than 0.001), but did not depend upon molecular size or charge. The serum amino acid values did not fall during continuous haemofiltration despite loss to the ultrafiltrate, suggesting that the losses were small when compared to the total body pool of free amino acids. However, in septic patients these losses may be of clinical importance in those who are continuously haemofiltered for long periods.
Renal Unit, Royal Liverpool Hospital, UK.
A
A
Davenport
N B
NB
Roberts
D000328:Adult; D000596:Amino Acids / Q000097:blood*; D019867:Anti-Glomerular Basement Membrane Disease / Q000150:complications; D005260:Female; D006440:Hemofiltration; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000628:therapy; D065227:Transfusion Reaction; D014462:Ultrafiltration
D000596:Amino Acids