Defective antibody-dependent tumour cell lysis by neutrophils from cancer patients.
Neutrophil antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells was studied in 32 patients with lung or gastro-intestinal carcinoma and 25 healthy controls. Seventeen of the patients (53%) had defective ADCC. Moreover, neutrophils obtained from patients with defective ADCC were found to bind IgG-coated target cells normally. Thus, the defect responsible for the impaired lysis appears to be distal to the Fc receptor (FcR)-mediated target cell binding by neutrophils.
University of Genova Medical School, Italy.
F
F
Dallegri
A
A
Ballestrero
L
L
Ottonello
F
F
Patrone
D000328:Adult; D000368:Aged; D000920:Antibody-Dependent Cell Cytotoxicity; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000276:immunology*; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D011961:Receptors, Fc / Q000032:analysis
D011961:Receptors, Fc