Identification of two murine loci homologous to the v-cbl oncogene.
The virally transduced oncogene v-cbl transforms fibroblasts in vitro and induces early B-cell-lineage lymphomas in vivo. A series of probes derived from a molecular clone of v-cbl were used to map related sequences in the mouse genome. Analyses of Chinese hamster x mouse somatic-cell hybrids showed that two related genes, cbl-1 and cbl-2, were located on chromosomes 6 and 9, respectively. Restriction enzyme studies of DNA from hybrid cells containing either chromosome 6 or 9 suggested that cbl-1 resembles v-cbl and may be a processed gene, whereas cbl-2 has a complex genomic structure. Analyses of Mus domesticus/M. spretus interspecific backcross mice showed that Cbl-1 maps between the immunoglobulin kappa light chain and T-cell receptor beta chain loci and that Cbl-2 is tightly linked to Thy-1.
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
D C
DC
Regnier
C A
CA
Kozak
D M
DM
Kingsley
N A
NA
Jenkins
N G
NG
Copeland
W Y
WY
Langdon
H C
HC
Morse
D000818:Animals; D002874:Chromosome Mapping; D051379:Mice; D008810:Mice, Inbred C57BL; D009857:Oncogenes; D011519:Proto-Oncogenes; D012689:Sequence Homology, Nucleic Acid