Cytotoxic activity of a series of heteroaryl-ONN-azoxy-sulphones and aryl sulphonylhydrazones.
Synthesis of heteroaryl-ONN-azoxysulphones and pyrazolyl-ONN-azoxycyanides was carried out by the action of the appropriate reagents on the corresponding nitroso derivatives. Pyrazolyl-ONN-azoxyamides were obtained by hydrolysis of the corresponding cyanides. Synthesis of the arylsulphonylhydrazones was carried out by reacting R-substituted phenyl-sulphonylhydrazines on the isomers of methylfuroxancarbaldehyde. Cytotoxic activity was assessed on HeLa cells. Some of the compounds tested inhibit the colony-forming ability of the tumor cells at low concentrations.
Istituto di Chimica Farmaceutica e Tossicologica dell' Università, Torino, Italia.
C
C
Tironi
R
R
Fruttero
A
A
Di Stilo
P
P
Aresca
R
R
Bossa
I
I
Galatulas
M
M
Ninci
D000970:Antineoplastic Agents / Q000494:pharmacology*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D006835:Hydrazones / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000494:pharmacology
D000970:Antineoplastic Agents; D006835:Hydrazones; D013450:Sulfones