Distribution of neurotoxic esterase in certain brain regions of laboratory animals.
Certain organophosphorous compounds caused the inhibition of 'neurotoxic esterase' present in central nervous system. The role of this enzyme is different from that of cholinesterase. The level of neurotoxic esterase in brain, corpus striatum and spinal cord of rats, mice, guineapigs and hens was measured. Maximum level of the enzyme was found in hens, followed by guineapigs, rats and mice in the order. The concentration of the enzyme was higher in corpus striatum greater than whole brain greater than spinal cord. The determination of the normal level of neurotoxic esterase may be useful in monitoring the exposure to organophosphorous compounds.
Industrial Toxicology Research Centre, Lucknow.
M A
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Matin
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Sattar
S N
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Khan
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Husain
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D002645:Chickens; D002802:Cholinesterases / Q000378:metabolism; D003342:Corpus Striatum / Q000201:enzymology; D005260:Female; D006168:Guinea Pigs; D051379:Mice; D051381:Rats; D013045:Species Specificity; D013116:Spinal Cord / Q000201:enzymology
D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase; D002802:Cholinesterases