Abnormal proteolysis (DIC)--successful treatment with antithrombin III concentrate and a concentrate containing F XIII and native von Willebrand factor.
Two patients with life-threatening disseminated intravascular coagulation (DIC) syndrome, one caused by Gram-negative bacteria and one by premature separation of the placenta, are described. Specific substitution was given by antithrombin III concentrate and AHF-Kabi, a low purity factor VIII concentrate containing native von Willebrand factor and factor XIII. The treatment quickly returned the extremely low levels of antithrombin III, factor VIII:C, fibrinogen and factor XIII, initially found, to normal, and also returned the multimeric pattern of von Willebrand factor to normal. This resulted in diminished bleeding, enabling surgical treatment of the underlying disease.
Department of Surgery, University of Lund, Malmö General Hospital, Sweden.
M
M
Delshammar
A
A
Lasson
I M
IM
Nilsson
K
K
Ohlsson
A
A
Wallmark
E
E
Vernersson
D000328:Adult; D000990:Antithrombin III / Q000627:therapeutic use*; D003537:Cystadenoma / Q000150:complications / Q000601:surgery; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000628:therapy*; D005176:Factor XIII / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy*; D013724:Teratoma / Q000150:complications / Q000601:surgery; D014841:von Willebrand Factor / Q000627:therapeutic use*
D014841:von Willebrand Factor; D000990:Antithrombin III; D005176:Factor XIII