[X-ray irradiation of donor blood in the complex treatment of suppurative diseases].
The authors discuss the use of donor blood after isolated exposure to X-rays in the complex treatment of 65 patients with various suppurative diseases. The therapeutic complex included in all cases transfusion of 250 ml of irradiated blood and subsequent antibiotic therapy. Study of antibiotic (penicillin) pharmacokinetics showed increase of its biological activity and prolongation of its presence in the blood in therapeutic concentrations for 24-48 hours. A scheme of antibiotic therapy in transfusion of irradiated blood is suggested. A formula for calculating the optimal irradiation dose is given. It is concluded that transfusion of irradiated blood followed by injection of an antibiotic raises the efficacy of antibiotic therapy, reduces the term of treatment, and increases the effect of postoperative management.
Ermolov
A S
AS
Mumladze
R B
RB
Korenkov
I P
IP
Andreev
V G
VG
Belopo'lskiĭ
A A
AA
D000293:Adolescent; D000328:Adult; D001769:Blood / Q000528:radiation effects*; D001803:Blood Transfusion; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000628:therapy*; D010400:Penicillin G / Q000008:administration & dosage; D010538:Peritonitis / Q000628:therapy*; D011879:Radiotherapy Dosage; D014946:Wound Infection / Q000628:therapy*
D010400:Penicillin G
Rentgenovskoe obluchenie donorskoĭ krovi v kompleksnom lechenii gnoĭnykh zabolevaniĭ.