Acute lymphoblastic leukemia with the 4;11 translocation exhibiting early T cell features.
We describe a case of ALL with the t(4;11) (q21;q23) translocation in which both surface markers and molecular analyses suggest an unusual early T cell involvement. While the morphologic and cytochemical studies showed an undifferentiated pattern, immunophenotypic data were suggestive of a very immature cell population which stained only for TdT and CD7. Moreover, in contrast to previous reports but in agreement with the immunologic findings, the IgH gene region retained a germline configuration. T cell receptor beta and gamma chain gene loci also showed a germline pattern, in accordance with the expansion of immature CD7+, TdT+ T cells.
Department of Biomedical Sciences and Human Oncology, University of Torino, Italy.
F
F
Lo Coco
P
P
Francia di Celle
G
G
Alimena
G
G
De Rossi
R
R
Gastaldi
G
G
Casorati
G
G
Saglio
R
R
Foa
D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics* / Q000473:pathology; D025063:Chromosome Disorders; D002894:Chromosomes, Human, Pair 4; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D007621:Karyotyping; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000235:genetics* / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology*; D014178:Translocation, Genetic