Complex cytogenetic aberrations in a well-differentiated chondrosarcoma.
The cytogenetic analysis of a well-differentiated (grade I) chondrosarcoma is presented. Despite a low-grade histopathology, metaphase preparations of tumor cells were characterized by numerous structural chromosome aberrations and a striking degree of genetic instability; the t(9;22)(q31;q12) that has been described recently in extraskeletal myxoid chondrosarcoma was not observed. This report suggests that chondrosarcomas may be heterogeneous cytogenetically. In chondrosarcoma, it appears that "high-grade" cytogenetic abnormalities do not necessarily engender a high-grade histology. These findings offer a possible explanation for the clinical aggressiveness of certain low-grade chondrosarcomas.
Fletcher
J A
JA
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.
Lipinski
K K
KK
Weidner
N
N
Morton
C C
CC
D000368:Aged; D002813:Chondrosarcoma / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D010386:Pelvic Neoplasms / Q000235:genetics* / Q000473:pathology
D005819:Genetic Markers