Optimal inhalation technique with terbutaline Turbuhaler.
The bronchodilator response after four different modes of inhalation of 0.25 mg terbutaline from a Turbuhaler was assessed, in a double-blind cross-over study, of 14 asthmatic children aged 8-14 yrs (mean 11.6 yrs). The children inhaled as fast as possible (mean peak inspiratory flow rate = 53 l.min-1), because fast inhalations have been found to be more efficient than slow inhalations when the Turbuhaler is used. Tilting the head back during inhalation and a breath-holding pause of 10 s after the inhalation had no significant effect upon bronchodilation. Furthermore, the response was the same whether the children inhaled from residual volume (RV) or functional residual capacity (FRC). These results suggest that this new inhaler can be used with a very simple inhalation technique without any loss of effect. A simple inhalation technique is likely to facilitate teaching and improve compliance.
Dept of Paediatrics, Kolding Hospital, Denmark.
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Hansen
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Pedersen
D000280:Administration, Inhalation; D000293:Adolescent; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D006801:Humans; D009330:Nebulizers and Vaporizers; D012123:Pulmonary Ventilation; D013726:Terbutaline / Q000008:administration & dosage / Q000627:therapeutic use*
D013726:Terbutaline