Antigonadal activity of the melatonin analogs 2-iodomelatonin and 2-chloromelatonin in the juvenile Djungarian hamster, Phodopus sungorus campbelli.
The antigonadal effects of daily (20 micrograms, s.c.) injection of melatonin and two analogs, 2-iodomelatonin and 2-chloromelatonin, were compared in juvenile Djungarian hamsters housed under long photoperiod (L:D 16:8). Melatonin, 2-iodomelatonin, and 2-chloromelatonin injected 3 h before lights off for 16 days (17-34 days of age) significantly inhibited testis growth compared to vehicle-injected hamsters. In addition, melatonin and both analogs significantly reduced body weight gain. These 2-substituted analogs appear to be melatonin agonists with a potency in vivo similar to the parent compound, melatonin.
Sugden
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Department of Physiology, King's College London.
D000818:Animals; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives* / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects*
C060754:2-chloromelatonin; C044556:2-iodomelatonin; D008550:Melatonin