[The potentials for immunization against influenza using liposome-incorporated viral surface antigens].
Studies were conducted using uni- and multilamellar liposomes to establish optimum conditions for influenza antigen incorporation in view of their transport to the target cells for experimental influenza prophylaxis in hybrid white mice. Radiometric determinations showed a good level of preparation purification, a good efficiency of incorporation in liposomes of the active biological material, the liposome linked radioactivity distribution among different organs. Charged liposomes induced solid and long lasting resistance against influenza control infection.
Institut de Virologie Stefan S. Nicolau, Bucarest, Roumanie.
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Burducea
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Marcheş
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Duţu
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Grancea
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Nicolau
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Păun
D000818:Animals; D000954:Antigens, Surface / Q000008:administration & dosage / Q000302:isolation & purification; D000956:Antigens, Viral / Q000008:administration & dosage* / Q000302:isolation & purification; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D007114:Immunization / Q000379:methods*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000302:isolation & purification; D008081:Liposomes; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*
D000954:Antigens, Surface; D000956:Antigens, Viral; D004337:Drug Carriers; D007252:Influenza Vaccines; D008081:Liposomes
Possibilités d'immunisation contre la grippe à l'aide d'antigènes viraux de surface incorporés aux liposomes.