Drug-induced toxic epidermal necrolysis treated with cyclosporin.
A 35-year-old woman developed toxic epidermal necrolysis secondary to phenytoin. Because the life-threatening eruption was resistant to prednisone and high-dose methylprednisolone therapy, cyclosporine therapy was initiated. Within 24-48 hours, the eruption stabilized and the patient improved.
Division of Dermatology, University of Connecticut Health Center, Farmington.
L
L
Renfro
J M
JM
Grant-Kels
L A
LA
Daman
D000328:Adult; D003524:Cyclosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D010672:Phenytoin / Q000009:adverse effects*; D011241:Prednisone / Q000627:therapeutic use; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors
D003524:Cyclosporins; D010672:Phenytoin; D011241:Prednisone; D008775:Methylprednisolone