Tritium toxicity in postnatally developing mouse brain: neurochemical changes after continuous exposure.
Since tritium may emerge as a major radiopollutant, an attempt has been made to evaluate changes in total cholesterol, phospholipid and glycogen content in the postnatally developing mouse brain from 1 to 6 weeks of age; the exposure, at a dose level of 11.1 kBq (0.3 microCi)/mL of 3H, through maternal drinking water, was from gestation day 15 until the last interval studied (after a maternal priming injection). The brain-to-body weight ratio was increased during postnatal development as compared to that of sham-irradiated controls. The phospholipid concentration decreased significantly in all age groups. By contrast, glycogen content tended to increase from 1 to 5 weeks of age, and cholesterol content increased by 40.35 and 44.75% during the 2nd and 3rd weeks, respectively, and returned to a near normal level at later intervals.
Pareek
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Department of Zoology, University of Rajasthan, Jaipur, India.
Jain
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Bhatia
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D000818:Animals; D001921:Brain / Q000378:metabolism / Q000528:radiation effects*; D002784:Cholesterol / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D051379:Mice; D010743:Phospholipids / Q000378:metabolism; D014316:Tritium / Q000009:adverse effects*
D010743:Phospholipids; D014316:Tritium; D006003:Glycogen; D002784:Cholesterol