Effects of synthetic human gastrin-releasing peptide on pancreatic exocrine secretion and release of pancreatic polypeptide in conscious rats.
The effects of a newly synthesized peptide, human gastrin-releasing peptide (hGRP), on the pancreatic exocrine secretion and the release of pancreatic polypeptide (PP) were examined in the conscious rat. Plasma PP concentrations were determined by a recently established specific radioimmunoassay for rat PP. Amounts of 0.18, 0.35, and 3.5 nmol/kg/h hGRP significantly stimulated both pancreatic exocrine secretion and 0.35 nmol/kg/h of hGRP increased PP release. Simultaneously infused proglumide (300 mg/kg/h) did not affect either pancreatic exocrine secretion or PP release. However, simultaneous infusion of atropine (100 micrograms/kg/h) slightly inhibited PP release, but did not restrict the incremental response of pancreatic protein secretion to hGRP. These results suggest that hGRP directly stimulates pancreatic exocrine secretion and PP release.
First Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
K
K
Miyasaka
K
K
Miyazaki
A
A
Funakoshi
K
K
Kitani
H
H
Yajima
D000818:Animals; D019886:Gastrin-Releasing Peptide; D005755:Gastrins / Q000494:pharmacology*; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008297:Male; D010189:Pancreatic Juice / Q000187:drug effects / Q000378:metabolism*; D010191:Pancreatic Polypeptide / Q000097:blood / Q000378:metabolism*; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D005755:Gastrins; D005768:Gastrointestinal Hormones; D010455:Peptides; D010191:Pancreatic Polypeptide; D019886:Gastrin-Releasing Peptide