[Effect of molsidomine preparations on the contractile function of the myocardium and coronary circulation in patients with ischemic heart disease complicated by heart failure after isometric load].
Isometric stress tests were conducted in 95 coronary patients and 15 normal subjects. Load tests were repeated 1 hr after a single dose administration and at the end of a two-week treatment course. Left-ventricular contractility was found to be impaired at isometric stress in 66.7% of patients showing no clinical signs of heart failure, and coronary insufficiency was detected in 44.1%. A single molsidomin dose reduced diastolic and systolic left-ventricular volume by an average of 10.9 and 13.3%, respectively. At repeated isometric stress after molsidomin administration, only 15.7% of patients showed ischemic ST displacement on the electrocardiogram. Eleven (32.4%) of 34 patients with early phases of heart failure showed increased ejection fraction and a higher myocardial fibre circular shortening rate (by 4.9 and 11.7%, respectively) during hand grip under molsidomin effect. Long-term treatment with molsidomin preparations produced general improvement in 84.4% of patients, as reflected in the reduction of the signs of heart failure as well as the rate and intensity of anginal attacks.
Alekperov
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EZ
D000284:Administration, Oral; D000286:Administration, Sublingual; D000328:Adult; D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D005080:Exercise Test; D005260:Female; D006801:Humans; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D008981:Molsidomine / Q000008:administration & dosage*; D009200:Myocardial Contraction / Q000187:drug effects*
D008981:Molsidomine
Vliianie preparatov molsidimina na sokratitel'nuiu funktsiiu miokarda i koronarnoe krovoobrashchenie u bol'nykh ishemicheskoĭ bolezn'iu serdtsa, oslozhnennoĭ serdechnoĭ nedostatochnost'iu, v usloviiakh izometricheskoi nagruzki.