Influence of experimental hypoxia on content and composition of free fatty acids in cerebral white matter.
The content and spectrum of free fatty acids were studied in the cerebral white matter, on Wistar rats exposed to acute hypoxia (2% of oxygen in a respiratory mixture) for 3 min. The total content of fatty acids, especially of tetraenoic ones, rose sharply already 4 min after hypoxia and persisted elevated even 2 months after the hypoxia. The results showed that the degradation of phospholipids-containing biological membranes in the nervous tissue of the white matter starts immediately after hypoxia, and is continued for months.
Department of Neurology, School of Medicine, Poznań, Poland.
M
M
Wender
Z
Z
Adamczewska-Goncerzewicz
A
A
Zórawski
E
E
Sroczyński
A
A
Grochowalska
D000818:Animals; D001923:Brain Chemistry; D002849:Chromatography, Gas; D005230:Fatty Acids, Nonesterified / Q000032:analysis* / Q000378:metabolism; D002534:Hypoxia, Brain / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D005230:Fatty Acids, Nonesterified