[The harmful action of ethanol on the liver: the role of alcohol dehydrogenase and aldehyde dehydrogenase].
White rats were divided into water-preferring (WP) and ethanol-preferring (EP) groups, on the basis of their preferable drink: either water or 15% solution of ethanol. Each of these groups was then subdivided into groups which were given to drink for 1 year 15% solution of ethanol (ethanol-treated) or water (controls). Alcohol dehydrogenase/aldehyde dehydrogenase activity ratios (ADH/AlDH) in livers of WP controls were considerably higher than those in EP controls. The difference in ADH/AlDH has somewhat decreased after ethanol treatment. However, this ratio remained the highest in the WP alcohol-treated group. The signs of proteinic and lipid dystrophy of the liver in alcohol-treated WP rats were expressed much more clearly than in all other groups. It is concluded that in the liver of animals with a high ADH/AlDH ratio there are favourable conditions for accumulation of a toxic hepatocyte-damaging acetaldehyde.
M S
MS
Usatenko
M A
MA
Petrova
N E
NE
Sokolovskaia
R P
RP
Anakina
Iu S
IuS
Borodkin
D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000437:Alcoholism / Q000201:enzymology / Q000209:etiology / Q000473:pathology; D000444:Aldehyde Dehydrogenase / Q000378:metabolism*; D000818:Animals; D000431:Ethanol / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D051381:Rats; D013997:Time Factors
D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase
Povrezhdaiushchee deĭstvie étanola na pechen': rol' alkogol'degidrogenazy i al'degiddegidrogenazy.