Intraperitoneal radiolabeled OC 125 in patients with advanced ovarian cancer.
Twenty patients with recurrent or persistent epithelial ovarian cancer failing conventional therapies were treated with a single intraperitoneal injection of iodine-131-labeled OC 125 monoclonal antibody. Rare acute side effects were nausea and mild diarrhea. At doses up to 120 mCi of iodine-131, median white blood cell and platelet count nadirs were 3.6k/microliters and 187k/microliters, respectively. Two patients acquired thyroid toxicities despite thyroid blockage with "cold" iodine. One patient had transient TSH elevation while remaining clinically euthyroid, and 1 patient developed activation of a thyroid nodule and clinical hyperthyroidism. Dose-limiting toxicity has not yet been observed. Twelve of 20 patients are alive 3 to 17 months following therapy. Tumor progression was noted in the majority of patients, although 3 patients had documented decreases in tumor burden of short duration. We conclude that, at the doses examined, iodine-131 OC 125 can be safely administered intraperitoneally.
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts.
N J
NJ
Finkler
M G
MG
Muto
A I
AI
Kassis
K
K
Weadock
S S
SS
Tumeh
V R
VR
Zurawski
R C
RC
Knapp
D000230:Adenocarcinoma / Q000097:blood / Q000401:mortality / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D002291:Carcinoma, Papillary / Q000097:blood / Q000401:mortality / Q000532:radiotherapy; D004715:Endometriosis / Q000097:blood / Q000401:mortality / Q000532:radiotherapy; D004906:Erythrocyte Count; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000627:therapeutic use; D051379:Mice; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000401:mortality / Q000532:radiotherapy*; D010976:Platelet Count
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes