Effect of lead nitrate administration on liver and kidney structure in rats.
A study was conducted on male albino rats ranging in weight between 150-180 g. The animals were given a single and repeated intravenous injections of lead nitrate (100 mu mol/kg body weight) once every 10 days for one, two, three and four injections respectively. Histopathological examination revealed that induction of hepatic and renal cellular proliferation without cellular necrosis occurred with single and repeated administration. No biochemical alterations in liver function tests and serum creatinine were detected throughout the whole period of study. These changes are suggested to be an adaptive response rather than a toxic effect.
Abdel-Aal
S F
SF
Shalaby
S A
SA
Badawy
A H
AH
Sammour
S A
SA
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D007668:Kidney / Q000187:drug effects*; D007854:Lead / Q000633:toxicity*; D008099:Liver / Q000187:drug effects*; D008297:Male; D009566:Nitrates / Q000633:toxicity*; D051381:Rats
D009566:Nitrates; D007854:Lead; C017461:lead nitrate