Effects of basic fibroblast growth factor (bFGF) on choline acetyltransferase activity and astroglial reaction in adult rats after partial fimbria transection.
Adult rats received a partial and unilateral transection of the fimbria. They received then intracerebroventricular (i.c.v.) injections of 5 microliters of Tris, half of them containing 2.5 ng of basic fibroblast growth factor (bFGF). They were injected twice a week for 4 weeks. At the end of this period, choline acetyltransferase (ChAT) activity was measured in the hippocampus. ChAT activity, which was decreased by the fimbria transection, was higher (by about 20%) in medial hippocampus of the bFGF group compared with the Tris group. In addition, bFGF enhanced the lesion-induced astroglial reaction by changing the morphology of the astrocytes and increasing the apparent number of these reactive astrocytes.
Barotte
C
C
Département de Neurophysiologie et de Biologie des Comportements, CNRS, Strasbourg, France.
Eclancher
F
F
Ebel
A
A
Labourdette
G
G
Sensenbrenner
M
M
Will
B
B
D000818:Animals; D001253:Astrocytes / Q000166:cytology* / Q000187:drug effects; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D003714:Denervation; D005260:Female; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D006624:Hippocampus / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D007150:Immunohistochemistry; D051381:Rats
D005346:Fibroblast Growth Factors; D002795:Choline O-Acetyltransferase