[Thermolabile inhibiting proliferation of connective tissue cell activity from platelets].
The action of a platelet extract (PE) and a heat-inactivated PE on 3T3 cells proliferation has been investigated. The heat-inactivated PE and platelet poor plasma (PPP) together can promote cell proliferation like fetal calf serum. At the same time PE inhibits proliferation of the cell culture stimulated by 5% fetal calf serum, whereas the heat-inactivated PE does not. Although the actions of 2% PE and 2% heat-inactivated PE on the cells incubated with PPP are equal, the stimulating effect of a 10% heat-inactivated PE is higher than that of a 10% PE. Thus, the inhibitor acts only at high concentrations. The role of the platelet-derived inhibitor in the limiting of extensive cell proliferation during vessel wall injury repair is discussed.
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MV
Blagosklonnyĭ
Zaritskiĭ
D001792:Blood Platelets / Q000378:metabolism*; D002455:Cell Division; D002457:Cell Extracts / Q000494:pharmacology; D003238:Connective Tissue / Q000378:metabolism; D003239:Connective Tissue Cells; D006358:Hot Temperature; D006801:Humans
D002457:Cell Extracts
Termolabil'naia ingibiruiushchaia proliferatsiiu soedinitel'no- tkannykh kletok aktivnost' iz trombotsitov.