A novel host-protective antigen from Trichostrongylus colubriformis.
The detergent-soluble fraction from Trichostrongylus colubriformis third-stage larvae contained a simple set of antigens, one of which (molecular weight 41,000) induced 43-51% protection in guinea pigs following immunization. Isolation and partial amino acid sequence analysis of this protective antigen showed it was parasite tropomyosin.
O'Donnell
I J
IJ
Dineen
J K
JK
Wagland
B M
BM
Letho
S
S
Werkmeister
J A
JA
Ward
C W
CW
D000595:Amino Acid Sequence; D000818:Animals; D000947:Antigens, Helminth / Q000032:analysis*; D006168:Guinea Pigs; D008969:Molecular Sequence Data; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*; D014252:Trichostrongyloidiasis / Q000662:veterinary*; D014253:Trichostrongylosis / Q000517:prevention & control / Q000662:veterinary*; D014254:Trichostrongylus / Q000276:immunology*; D014335:Tropomyosin / Q000032:analysis*; D014611:Vaccination / Q000662:veterinary
D000947:Antigens, Helminth; D014335:Tropomyosin