[An experimental study on the anti-senility effects of shou xing bu zhi].
This paper presents the anti-senility effects of Shou Xing Bu Zhi (SXBZ. made of thirteen herbs: Polygonum multiflorum, Codonopsis silvestris, Astragalus membranaceus, Poria cocos, etc.) in mice. The mice were administered with the SXBZ orally at dosage of 10 g/kg daily for three months. The results showed that the lipofuscin of liver and brain tissues was significantly reduced in both young (1 month old) and adult (11 months) mice. Examination of lipid peroxidation of liver tissue revealed a marked decrease in adult mice. The lipid peroxidation of rat liver homogeneous was obviously inhibited after culturing with drug solutions (5.0 mg/0.1 ml), 37 degrees C for 90 minutes in vitro. In addition, the diminution of hydroxyproline of skin in both young and adult mice was observed. Results of this study indicated that the SXBZ was effective in slowing down aging.
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Chen
D000375:Aging / Q000187:drug effects*; D000818:Animals; D027885:Astragalus propinquus; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D008062:Lipofuscin / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D051381:Rats; D014018:Tissue Distribution
D004365:Drugs, Chinese Herbal; D008062:Lipofuscin