Urethane as a sole general anaesthetic in cats used for electroretinogram studies.
Cats are very sensitive to induction of anaesthesia by urethane. To anaesthetize cats with urethane, 1.0-1.3 g/kg, of freshly prepared urethane is administered intravenously at a rate of 1.92 g/h, while anaesthesia is maintained with 0.5% halothane in a 66%/33% nitrous oxide/carbogen gas mixture. Cats can then be maintained for up to 3 days by intravenous infusion at a rate of 4 ml/h of a 100 ml solution containing 50 IU heparin, 2.4 mg atropine, 4.7 g anhydrous D-glucose, and 240 mg urethane/kg. Using this anaesthetic, excellent electroretinograms can be recorded with no interfering eye movements.
Department of Ophthalmology, University of Sydney, N.S.W., Australia.
T J
TJ
Millar
Vaegan
A
A
Arora
D000758:Anesthesia; D000818:Animals; D001285:Atropine / Q000008:administration & dosage; D002415:Cats; D004596:Electroretinography; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006221:Halothane / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D011247:Pregnancy; D014520:Urethane / Q000008:administration & dosage*
D014520:Urethane; D001285:Atropine; D006493:Heparin; D005947:Glucose; D006221:Halothane