[Effect of tyrosine on progesterone and hCG production by human trophoblast cells in vitro].
The purpose of the present study was to investigate the effect of tyrosine on progesterone and hCG production by human placental cells in vitro. The results showed that the three concentrations (0.02 mmol/L, 0.2 mmol/L and 2mmol/L) of tyrosine inhibited progesterone secretion by trophoblast cells in vitro. While progesterone secretion was suppressed by tyrosine, hCG secretion was unchanged. Thus, it seems unlikely that the suppression of progesterone production by tyrosine was due to a decrease in hCG production. It was further demonstrated that tyrosine inhibited 3 beta-HSD activity of trophoblast cells, indicating that the progesterone production inhibition by them might be due to the decreased 3 beta-HSD activity of trophoblast cells.
Yang
X S
XS
Yang
X
X
Ma
Q N
QN
Cheng
Z P
ZP
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D002478:Cells, Cultured; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism*; D014327:Trophoblasts / Q000166:cytology / Q000378:metabolism*; D014443:Tyrosine / Q000494:pharmacology*
D006063:Chorionic Gonadotropin; D014443:Tyrosine; D011374:Progesterone; D015096:3-Hydroxysteroid Dehydrogenases