[Hereditary sensory motor neuropathy: degenerative disease or a disease with an immune-mediated pathogenesis?].
The clinical data proving that some hereditary motor-sensory neuropathies (HMSN type 1) are steroid sensitive may indicate inflammatory or immunomediated mechanisms as cofactors contributing to the clinical course of these disorders. The finding of HLA-DR positivity of Schwann cells in HMSN type I along with the presence in some cases of inflammatory infiltrates in nerve sections provides further evidence for this hypothesis.
Cadoni
A
A
Zicca
A
A
Mancardi
G L
GL
De Martini
I
I
Schenone
A
A
Zaccheo
D
D
D001327:Autoimmune Diseases / Q000473:pathology*; D002607:Charcot-Marie-Tooth Disease / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D009134:Muscular Atrophy, Spinal / Q000209:etiology*; D011129:Polyradiculoneuropathy / Q000150:complications; D012583:Schwann Cells / Q000473:pathology*; D013497:Sural Nerve / Q000473:pathology
Le neuropatie ereditarie sensitivo motorie: malattie degenerative o malattie a patogenesi immuno-mediata?