Preventive effect of taurine against acute paraquat intoxication in beagles.
The continuous infusion of taurine markedly protected against paraquat (PQ)-induced oliguria in beagles. Pharmacokinetic studies revealed that taurine infusion increased the blood concentration of PQ and reduced the net content in the kidney and, to a lesser extent, in the lung. The excretion of PQ into the urine was unaltered. The infusion of glycine did not have such effects.
Department of Pharmacology, Faculty of Medicine, Kagoshima University, Japan.
K
K
Izumi
R
R
Nagata
T
T
Motoya
J
J
Yamashita
T
T
Hirokane
T
T
Nagata
Y
Y
Satoh
Y
Y
Sawada
M
M
Ishibashi
H
H
Yoshida
D000818:Animals; D004285:Dogs; D005260:Female; D007262:Infusions, Intravenous; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D010269:Paraquat / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity; D013654:Taurine / Q000494:pharmacology*; D014563:Urodynamics / Q000187:drug effects
D013654:Taurine; D010269:Paraquat