[Effect of delta-sleep inducing peptide on electrical instability of the heart in emotional stress].
The effect of the delta-sleep inducing peptide (DSIP) on disorders of the cardiac rhythm in emotional stress was studied in experiments on rabbits. DSIP (60 nmol/kg) diminished or arrested ventricular extrasystole occurring in experimental emotional stress. It was shown that the antiarrhythmic effect of DSIP is most manifest if it is injected just before exposure to the stress factors. DSIP injection induces increase of the thresholds of the occurrence of ventricular fibrillation and its precursors in intact animals. This can explain the high preventive effect of DSIP in stress. The acquired data on the antiarrhythmic effect of DSIP should be taken into consideration in elaborating preventive recommendations aimed at raising the organism's stability to stress factors.
Arkhangel'skaia
M I
MI
Zviagintseva
M A
MA
D000818:Animals; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D013315:Stress, Psychological / Q000503:physiopathology*
D003701:Delta Sleep-Inducing Peptide
Vliianie peptida del'ta-sna na élektricheskuiu nestabil'nost' serdtsa pri émotsional'nom stresse.