[The spectrum of lymphadenopathy in HIV-positive patients. Prospective analysis of 45 cases].
In the prospective analysis of 45 patients (intravenous drug addicts and homosexuals) with lymphadenopathy and positive HIV virus titers, including serology, immunological and histological lymph node studies, we examined the etiology and diagnostic results of the methods used. We found 19 cases with lymphoid follicular hyperplasia, 9 with lymph node tuberculosis, 7 with lymphoid depletion, 2 non-Hodgkin's lymphoma and one case with Hodgkin's disease. Routine serology did not provide more information concerning the lymphadenopathy and the immunological study showed a relationship, however not lineal, between the immunosuppression and the stage of HIV infection, while the histologic diagnosis did not, except in the cases with lymphoid depletion and non-Hodgkin's disease. In the asymptomatic patients (10 cases) biopsy results did not change the given treatment as well as the prognosis, thus, it could be eliminated in a routine study. Biopsy on occasions implied therapeutic management (lymph node tuberculosis) or a change in prognosis (lymphoma or lymphoid depletion) in symptomatic patients (35), therefore, it seems to de justified. Fine needle aspiration of the lymph nodes was harmless and safe and was shown to have good sensitivity (79%), thus, it can be recommended as a first elective diagnostic method for lymph node histology.
Domínguez
A
A
Peña
J M
JM
González
J J
JJ
Martínez
M A
MA
Fernández
J
J
Barbado
F J
FJ
Vázquez
J J
JJ
D000328:Adult; D001707:Biopsy, Needle; D005260:Female; D006679:HIV Seropositivity / Q000150:complications*; D006716:Homosexuality; D006801:Humans; D008206:Lymphatic Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019966:Substance-Related Disorders / Q000150:complications / Q000276:immunology / Q000473:pathology
El espectro de la linfadenopatía en pacientes VIH positivos. Análisis prospectivo de 45 casos.