Expression of tumor necrosis factor at a specific developmental stage of mouse embryos.
We investigated the expression of the tumor necrosis factor (TNF) gene during development of mouse embryos, and observed its transient expression on Days 9 and 10 of gestation. We also detected a 25-kDa protein showing immunological cross-reactivity with mouse TNF antibody in an extract of 10-day embryos. These results suggest that TNF plays a role in mammalian ontogenesis.
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
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Ohsawa
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Natori
D000818:Animals; D005314:Embryonic and Fetal Development; D005786:Gene Expression Regulation; D005865:Gestational Age; D051379:Mice; D008813:Mice, Inbred ICR / Q000196:embryology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D014409:Tumor Necrosis Factor-alpha