Effect of manganese on some bioantioxidants in various organs of protein-deficient rats.
The effect of manganese exposure (Mn2+ 4 mg Mn/kg intraperitoneally) on certain bioantioxidants in brain, liver, kidney and testes in growing rats maintained on 21% and 8% casein diet were investigated. Manganese administration for 30 days caused significant reduction in the level of GSH (reduced glutathione) in liver and testes and GR (glutathione reductase) and G-6-PDH (glucose-6-phosphate dehydrogenase) in brain, liver and testes. The magnitude of alteration was greater in 8% casein diet fed animals compared to rats maintained on 21% casein diet. These results indicate that protein deficient animals are more susceptible to the manganese induced biochemical changes in various tissues. The mechanism of such changes is discussed.
Neurotoxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
R S
RS
Srivastava
R C
RC
Murthy
S V
SV
Chandra
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D020149:Manganese Poisoning; D010084:Oxidation-Reduction; D011488:Protein Deficiency / Q000378:metabolism*; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000378:metabolism
D005954:Glucosephosphate Dehydrogenase; D005980:Glutathione Reductase; D005978:Glutathione