Elevated levels of the 90 kd heat shock protein in a proportion of SLE patients with active disease.
The human 90 kd heat shock protein (hsp 90) is associated with the receptor for glucocorticoid hormones and is believed to play a role in the cellular response to corticosteroids. The levels of this protein in the peripheral blood lymphocytes of patients with systemic lupus erythematosus (SLE) have been investigated and compared with those observed in normal individuals and patients with rheumatoid arthritis. Fifteen percent of SLE patients were found to exhibit hsp 90 levels well in excess of those observed in the other groups. These patients all had active disease. The significance of these findings is discussed both in terms of the disease processes occurring in these patients and the efficacy of steroid therapy.
Department of Biology, University College London, UK.
P M
PM
Norton
D A
DA
Isenberg
D S
DS
Latchman
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood; D005260:Female; D006360:Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D008214:Lymphocytes / Q000032:analysis*; D008297:Male; D008875:Middle Aged
D000305:Adrenal Cortex Hormones; D006360:Heat-Shock Proteins