An evaluation of diphtheria--tetanus (adult) vaccine in unselected human volunteers.
One hundred unselected adult volunteers received an adult diphtheria (less than 2 Lf)-tetanus (greater than or equal to 40 IU) adsorbed vaccine without prior Schick testing. No volunteer had a moderate or severe reaction although 39% complained of a transient sore arm. Only 10% reported local erythema. Of the study group, 37/43 (86%) patients who were initially seronegative for diphtheria attained levels normally considered as seropositive. The results confirm the safety and efficacy of adult diphtheria-tetanus vaccine and allow its recommendation for use in 'at risk' individuals without the need for prior Schick testing.
Harcus
A W
AW
Medicos, Kingston-upon-Hull, UK.
Ward
A E
AE
Roberts
J S
JS
Bryett
K A
KA
D000328:Adult; D004168:Diphtheria Toxoid / Q000008:administration & dosage / Q000009:adverse effects; D022422:Diphtheria-Tetanus Vaccine; D004338:Drug Combinations / Q000008:administration & dosage / Q000009:adverse effects; D004890:Erythema; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D007273:Injections, Intramuscular; D008297:Male; D013745:Tetanus Toxoid / Q000008:administration & dosage / Q000009:adverse effects
D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D004338:Drug Combinations; D013745:Tetanus Toxoid