Ionophoretic activities of oligopeptide lactones and resin-glycosides in human erythrocytes.
Oligopeptide lactones (theonellapeptolides) isolated from the Okinawan marine sponge Theonella swinhoei and resin-glycosides (merremosides) from the tuber of an Indonesian medicinal plant Merremia mammosa were examined regarding their activities in transporting Na+, K+, and Ca++ ions into human erythrocytes. Each of these lactones, which had been shown, using a supported liquid membrane, to have an ionophoretic effect on the alkali metal ions, transported the ions to a different extent. The ion transporting activities of these compounds were completely lost when the macrocyclic lactone structures were cleaved by sodium methylate. Resin-glycosides with an additional branched glycosyl residue showed much greater ion transporting activities than those without it.
Kitagawa
I
I
Ohashi
K
K
Kawanishi
H
H
Shibuya
H
H
Shinkai
K
K
Akedo
H
H
D004912:Erythrocytes / Q000032:analysis*; D006027:Glycosides / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D007478:Iontophoresis; D007783:Lactones / Q000097:blood*; D009842:Oligopeptides / Q000097:blood*; D012116:Resins, Plant
D006027:Glycosides; D007783:Lactones; D009842:Oligopeptides; D012116:Resins, Plant