Role of cadmium in hypertensive patients with renal parenchymal disease.
In our study we investigated 36 out-patients with renal disease; 22 of them were hypertensive. In all patients proteinuria was present (4.30 +/- 0.82 g protein/d) and renal involvement has been proved by renal biopsy. Blood cadmium in nonsmokers was significantly (P less than .05) lower than in smokers. Patients with renal hypertension showed a significantly higher (P less than .05) urine cadmium excretion/d (1.60 +/- 0.23 micrograms/d) compared to normotensives with a disease of the kidney (1.14 +/- 0.38 micrograms/d). Our results indicate that cadmium may be involved in the development of hypertension in patients with renal disease.
University of Wuerzburg, Department of Medicine, Federal Republic of Germany.
H
H
Geiger
U
U
Bahner
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S
Anderes
A
A
Heidland
D002104:Cadmium / Q000097:blood / Q000502:physiology* / Q000652:urine; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D008297:Male; D009994:Osmolar Concentration
D002104:Cadmium