Pharmacological manipulation of postoperative intestinal adhesions.
Paralytic ileus and intestinal adhesions are common events following intra-abdominal surgery. The theoretical hypothesis 'that stimulation of the postoperative bowel will reduce intestinal adhesions' was studied in a rat model for intestinal adhesions in which postoperative bowel motility was pharmacologically manipulated. Immediate postoperative stimulation of gastrointestinal motility by the prokinetic agent, Cisapride, resulted in a significant reduction in both the number and extent of adhesions. Inhibition of postoperative intestinal motility with the anticholinergic agent, atropine, resulted in a greater number of more dense adhesions involving an increased length of bowel.
Sparnon
A L
AL
Department of Paediatric Surgery, University of London, England.
Spitz
L
L
D000818:Animals; D020117:Cisapride; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D007410:Intestinal Diseases / Q000517:prevention & control*; D007418:Intestinal Pseudo-Obstruction / Q000209:etiology / Q000517:prevention & control; D010880:Piperidines / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*
D010880:Piperidines; D012702:Serotonin Antagonists; D020117:Cisapride