Radioiodination for therapy.
A method for the radioiodination of antibodies for therapy is described. The method resulted in a high efficiency of labelling (88-94%) with negligible damage to the antibody. Good localisation of labelled antibody was demonstrated. Doses of radiation to operators were very low.
Department of Medical Oncology, Charing Cross Hospital, London, UK.
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Adam
D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D001974:Bromosuccinimide; D004337:Drug Carriers; D004781:Environmental Exposure; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000276:immunology / Q000532:radiotherapy
D000911:Antibodies, Monoclonal; D004337:Drug Carriers; D007457:Iodine Radioisotopes; D001974:Bromosuccinimide