An inhibitor of cellular cytotoxicity is present in multiple sclerosis.
A blocking factor is present in the serum of patients with multiple sclerosis (MS). It is able to inhibit a cellular cytotoxicity reaction in vitro. This substance has characteristics similar to those of the 'P4' protein described in pregnant women and patients bearing tumors. Its possible contribution to MS pathogenesis is discussed.
Service d'Immunologie Cellulaire, Centre de Transfusion et d'Hématologie de Bordeaux, France.
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Fizet
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Ferrer
D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D009103:Multiple Sclerosis / Q000097:blood / Q000276:immunology*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood / Q000276:immunology*
D011257:Pregnancy Proteins