Neurogenic muscle hypertrophy. Report of two cases.
Muscle hypertrophy is rare in denervating diseases. A patient with calf enlargement associated with L5-S1 radiculopathy and another with thenar, hypothenar, forearm and calf muscle hypertrophy in the course of chronic relapsing inflammatory demyelinating polyneuropathy are described. Gastrocnemius muscle biopsy revealed both type I and type II fibre hypertrophy in the former case and predominant type I fibre hypertrophy in the latter. Passive stretching and abnormal spontaneous muscular activity might have played a role in the origin of hypertrophy in both patients, but a satisfactory explanation for denervation hypertrophy has yet to be provided.
Istituto Neurologico C. Besta, Milan, Italy.
D
D
Pareyson
L
L
Morandi
V
V
Scaioli
R
R
Marazzi
A
A
Boiardi
A
A
Sghirlanzoni
D001706:Biopsy; D006801:Humans; D006984:Hypertrophy; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*; D009135:Muscular Diseases / Q000473:pathology*