Elevated gastric acid secretion in patients with Barrett's metaplastic epithelium.
Gastric acid secretion in response to a protein meal and to exogenously administered synthetic human gastrin 17-I was measured in patients with Barrett's esophagus, patients with uncomplicated gastroesophageal reflux, and normal age- and sex-matched controls. Acid secretion, both basally and in response to gastrin 17-I, was significantly greater in patients with Barrett's esophagus compared to normal individuals without reflux. Basal gastrin levels and meal-stimulated levels of the hormone were similar among all three groups. Sensitivity to gastrin, expressed as the concentration causing half-maximal acid secretion, was also similar among the study groups. It is speculated that elevated basal acid production in Barrett's esophagus may contribute to the pathogenesis of the disorder.
Mulholland
M W
MW
Department of Surgery, University of Washington, Seattle.
Reid
B J
BJ
Levine
D S
DS
Rubin
C E
CE
D001471:Barrett Esophagus / Q000150:complications / Q000378:metabolism*; D002908:Chronic Disease; D002927:Cimetidine / Q000494:pharmacology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005755:Gastrins / Q000097:blood; D005764:Gastroesophageal Reflux / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D019832:N-Methylscopolamine; D010276:Parasympatholytics / Q000494:pharmacology; D012602:Scopolamine Derivatives / Q000494:pharmacology
D005755:Gastrins; D010276:Parasympatholytics; D012602:Scopolamine Derivatives; C013550:gastrin 17; D002927:Cimetidine; D019832:N-Methylscopolamine