[Changes in gastric mucosal blood flow after selective proximal vagotomy; an experimental study in rats].
The effect of selective proximal vagotomy (SPV) on gastric mucosal blood flow (MBF) was studied in rats using hydrogen gas clearance technique. The following results were obtained. 1) Resting MBF of the corpus decreased significantly from 106.3 +/- 9.8 ml/min/100g to 74.5 +/- 15.5 ml/min/100g at 12 weeks after SPV (p less than 0.01). Resting MBF of the antrum did not decrease. 2) Tetragastrin, betazol-HCl and 2-deoxy-d-glucose (2DG)-stimulated acid outputs were reduced following SPV for more than 12 weeks after operation. 3) The increase of corporal MBF after tetragastrin, betazol-HCl and 2DG stimulation was less significant with accompanying reduction of acid output. 4) The increase of antral MBF after tetragastrin or betazol-HCl stimulation was less significant after SPV. But, the increase after 2DG stimulation was as much as after SPV.
Second Department of Surgery, Yokohama City University School of Medicine, Japan.
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D000818:Animals; D001625:Betazole; D003847:Deoxyglucose; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D006859:Hydrogen / Q000032:analysis; D008297:Male; D011706:Pyloric Antrum; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013758:Tetragastrin; D014629:Vagotomy, Proximal Gastric
D013758:Tetragastrin; D001625:Betazole; D006859:Hydrogen; D003847:Deoxyglucose