[Effect of the ascorbic acid of the aqueous humor on the lipid peroxidation process in the eye in primary open-angle glaucoma].
Investigations of aqueous humor in primary open-angle glaucoma have shown a change in its normal contents: decreased ascorbic acid in it and increased secondary products of lipid peroxidation. In patients with glaucoma of stages III and IV, a correlative relationship between them is recorded (r = -0.78). It is suggested that in the pathomechanism of increased intraocular pressure in primary glaucoma activation of the process of lipid peroxidation plays a role due to decreased concentration of ascorbic acid in the aqueous humor, being one of the most important components of antioxidative system of the eye.
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Aleksidze
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Beradze
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Golovachev
D000368:Aged; D001082:Aqueous Humor / Q000032:analysis / Q000378:metabolism*; D001205:Ascorbic Acid / Q000032:analysis / Q000378:metabolism*; D002386:Cataract / Q000378:metabolism; D005260:Female; D005902:Glaucoma, Open-Angle / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D013053:Spectrophotometry; D013858:Thiobarbiturates
D013858:Thiobarbiturates; C029684:thiobarbituric acid; D001205:Ascorbic Acid
Vliianie askorbinovoĭ kisloty vodianistoĭ vlagi na protsess perekisnogo okisleniia lipidov v glazu pri pervichnoĭ otkrytougol'noĭ glaukome.