Mechanism of action of alpha-methylene-gamma-lactone derivatives of substituted nucleic acid bases in tumour cells.
Some alpha-methylene-gamma-lactone derivatives of substituted nucleic acid bases, which showed significant antitumour activity against experimental tumours, were tested for their possible mechanism of action. Derivatives 1, 4 and 7 strongly inhibit active transport of uridine through sarcoma-180 ascites tumour cells. Derivatives 1, 7 and 10 strongly inhibit a translation process in these cells, besides apparent inhibition in transcription. It appears that active transport and translation might be the primary steps inhibited by these drugs.
Department of Biochemistry, Chittaranjan National Cancer Research Centre, Calcutta, India.
C K
CK
Panda
K
K
Choudhury
U
U
Sanyal
S K
SK
Chakraborti
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009696:Nucleic Acids / Q000494:pharmacology*; D014176:Protein Biosynthesis / Q000187:drug effects; D014158:Transcription, Genetic / Q000187:drug effects
D000970:Antineoplastic Agents; D009696:Nucleic Acids; C014096:alpha-methylene gamma-butyrolactone; D015107:4-Butyrolactone