Hepatic mitochondrial membranolysis repairing by spermidine.
Hepatic mitochondrial membrane lysis is caused due to excess vitamin A, has been repaired by spermidine. This fact has been proved by estimating membrane proteins, lipids, phospholipase A2 activity and membrane phospholipids of rat liver mitochondria by studying the effect of spermidine on membranolytic effect of excess vitamin A. Spermidine has been found to inhibit the activity of phospholipase A2 and thus stabilize the hepatic mitochondrial membranes in the hypervitaminoic A model, that is to say, the spermidine tries to bring down the enormously elevated levels of phospholipase A2 by administration of excess vitamin A in rats.
Chandra
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Department of Chemistry, University of Delhi, India.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury; D007425:Intracellular Membranes / Q000187:drug effects / Q000473:pathology; D008107:Liver Diseases / Q000188:drug therapy; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000473:pathology; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013095:Spermidine / Q000627:therapeutic use*; D014801:Vitamin A / Q000037:antagonists & inhibitors* / Q000633:toxicity
D010743:Phospholipids; D014801:Vitamin A; D010741:Phospholipases A; D054467:Phospholipases A2; D013095:Spermidine