Sustained elevation in hippocampal NGF-like biological activity following medial septal lesions in the rat.
Several laboratories have documented an increase in hippocampal nerve growth factor (NGF) levels, measured with biological or immunological assays, within 1-2 weeks following septal lesions or fimbria/fornix transections. In the present study we have determined the increase in NGF-like biological activity in medium conditioned by hippocampal slices at more prolonged times following medial septal lesion. In contrast to reports based on immunological assays, which demonstrate a transient increase in hippocampal NGF, elevated NGF-like biological activity was present in hippocampal slice-conditioned medium up to one year after a medial septal lesion.
Collins
F
F
Synergen, Inc., Boulder, CO 80301.
Crutcher
K A
KA
D000818:Animals; D001681:Biological Assay; D005260:Female; D006624:Hippocampus / Q000378:metabolism* / Q000502:physiology; D009414:Nerve Growth Factors / Q000378:metabolism* / Q000502:physiology; D009416:Nerve Regeneration; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000502:physiology*
D009414:Nerve Growth Factors