[Experiences with the squamous cell carcinoma antigen, a new tumor marker for cancer of the uterine cervix].
Squamous cell carcinoma (SCC) antigen was first described 1977 by Kato et al. in patients with carcinoma of the cervix uteri. SCC serum levels can be measured with a radioimmunoassay (Abbott), in our investigation 2.0 ng/ml were taken as the upper limit of the standard range. In 35 healthy women there were no elevated SCC serum levels. In only 2 of 50 patients with benign gynaecological diseases SCC was also elevated. 59% of the 102 patients with primary and 70% of the 63 patients with recurrent cervical cancer showed pathologic values, CEA was elevated in 32% and 51% respectively; the mean serum concentrations increased with the stage of the disease. 68% of 142 patients with squamous cell carcinoma had elevated levels, in 5 of 9 adenosquamous carcinomas and in 3 of 14 adenocarcinomas SCC was in the pathological range. 13 of 60 patients with breast, endometrial and ovarian cancer showed elevated values. SCC shows a high specificity and a high sensitivity for squamous cell carcinomas of the cervix uteri. The tumor marker might be helpful in the control of the primary therapy and follow-up of cervical cancer patients.
Frauenklinik und Institut für Klinische Chemie, Ludwig-Maximilians-Universität, München.
W
W
Meier
W
W
Eiermann
P
P
Stieber
A
A
Fateh-Moghadam
H
H
Hepp
D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000175:diagnosis; D015843:Serpins; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D014594:Uterine Neoplasms / Q000175:diagnosis
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D015843:Serpins; C051072:squamous cell carcinoma-related antigen
Erfahrungen mit SCC-Antigen, einem neuen Tumormarker für Karzinome der Cervix uteri.