[Functional and morphologic investigations of the human adrenal cortex in various diseases].
The paper is devoted to investigations of the human adrenal cortex on autopsy material obtained 1 h after death. The purpose was to study the features of 3 cortical zones in some diseases with relation to sex and age. Quantitative histoenzymological analysis was used, metabolic indices of corticocytes and the cortical microvascular wall in 3 functionally differentiated zones (glomerular, fascicular and reticular) were estimated. Histoenzymological reactions were subjected to cytospectrophotometric analysis with subsequent statistical processing of data array. Age-related features of the adrenal cortex differed considerably among men and women, and were associated with corticocytes as well as with the cortical microvascular wall. There was no age-related decrease in enzymatic activity in all the adrenocortical structures but there was change in the interrelationship among the 3 differentiated zones. In some diseases change of enzymatic activity proper was noted in all the zones however a histotopogram of the cortex typical of a given age, was preserved. Functional and morphological investigations permitted assessment of the rearrangement of intraadrenal homeostasis, reflecting, probably, shifts in the synthesis of the main 3 classes of corticosteroid hormones.
Rostovtseva
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TI
Musakov
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AN
D000302:Adrenal Cortex / Q000473:pathology / Q000503:physiopathology*; D000328:Adult; D000367:Age Factors; D001161:Arteriosclerosis / Q000473:pathology / Q000503:physiopathology; D002908:Chronic Disease; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology; D008171:Lung Diseases / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012213:Rheumatic Fever / Q000473:pathology / Q000503:physiopathology; D012737:Sex Factors
Funktsional'no-morfologicheskoe issledovanie kory nadpochechnikov cheloveka pri nekotorykh zabolevaniiakh.