The in vitro reduction of dimethylpropion.
A study of the in vitro metabolism of dimethylpropion using different tissue homogenates of certain animals showed that: 1. Only the two major metabolites of dimethylpropion, i.e., methylpseudoephedrine and monomethylpropion were formed. 2. Species variation was observed with regard to the reductive ability of the liver homogenates. 3. Anaerobic conditions favored in vitro reduction to form methylpseudoephedrine. 4. The liver-soluble fraction exhibited the highest enzymatic reductive activity toward dimethylpropion. 5. Significant metabolic reduction of dimethylpropion was exhibited by the soluble fraction of the kidney.
Department of Pharmacy, King's College London.
S L
SL
Markantonis
A
A
Kyroudis
A H
AH
Beckett
D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D007668:Kidney / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010084:Oxidation-Reduction; D011427:Propiophenones / Q000378:metabolism*; D011817:Rabbits; D013154:Spleen / Q000378:metabolism; D013347:Subcellular Fractions / Q000378:metabolism
D011427:Propiophenones; C034349:metamfepramone; D009247:NADH, NADPH Oxidoreductases