HPLC studies on the degradation profiles of glucose 5% solutions subjected to heat sterilization in a microprocessor-controlled autoclave.
A practically useful relationship between degradation and F0 at various temperatures is given. This may be of value for identifying the most suitable sterilization conditions for a number of glucose products and other pharmaceuticals. It was found that autoclaving at a high temperature to a low final F0 value gave the maximum product integrity.
Cook
A P
AP
Area Pharmaceutical Laboratory, Ninewells Hospital, Dundee, U.K.
MacLeod
T M
TM
Appleton
J D
JD
Fell
A F
AF
D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D005947:Glucose / Q000032:analysis*; D006358:Hot Temperature; D008838:Microcomputers; D012996:Solutions; D013242:Sterilization / Q000295:instrumentation*
D012996:Solutions; D005947:Glucose