Developmental alternations in offspring of female rats orally intoxicated by aluminum chloride or lactate during gestation.
The oral treatment of pregnant rats by aluminum chloride or lactate at various doses was applied from day 1 to day 21 of gestation to determine its influence on mortality, weight evolution, and neuromotor maturation of their pups. No effect of treatment on litter size was detected, but an increased mortality appeared during the first week: treatment by aluminum lactate was less active than was an equivalent treatment by aluminum chloride. Weight was transitorily delayed, but the reversal of this effect could be attributed to the decrease of litter size. The neuromotor maturation of surviving pups treated with the two aluminum salts showed an important impairment during the first 2 weeks of postnatal life.
Centre des Sciences de l'Environnement, Neurotoxicologie, Université de Metz, France.
V
V
Bernuzzi
D
D
Desor
P R
PR
Lehr
D000284:Administration, Oral; D000535:Aluminum / Q000633:toxicity*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D002712:Chlorides / Q000633:toxicity*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D007773:Lactates / Q000633:toxicity*; D008098:Litter Size / Q000187:drug effects; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D012018:Reflex / Q000187:drug effects
D017607:Aluminum Compounds; D002712:Chlorides; D007773:Lactates; D000077410:Aluminum Chloride; D000535:Aluminum