Effect of supernatants derived from T lymphocyte culture in minimal change nephrotic syndrome on rat kidney capillaries.
The effect on the kidney capillaries of T lymphocyte culture supernatants from patients with minimal change nephrotic syndrome was studied by infusion into the left renal artery of rats. The supernatants of T lymphocyte cultures from nephrotic patients induced significant proteinuria and a reduction of anionic sites in the glomerular basement membrane of the kidneys in the rats. These changes were not produced in rats receiving equivalent supernatants from healthy controls.
Maruyama
K
K
Department of Pediatrics, Gunma University School of Medicine, Japan.
Tomizawa
S
S
Shimabukuro
N
N
Fukuda
T
T
Johshita
T
T
Kuroume
T
T
D000818:Animals; D000838:Anions / Q000378:metabolism; D001485:Basement Membrane / Q000378:metabolism; D001665:Binding Sites; D002196:Capillaries / Q000187:drug effects; D002478:Cells, Cultured; D002648:Child; D003470:Culture Media; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism / Q000648:ultrastructure; D008222:Lymphokines / Q000652:urine; D008297:Male; D009402:Nephrosis, Lipoid / Q000378:metabolism*; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation; D013601:T-Lymphocytes / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D000838:Anions; D003470:Culture Media; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors