O-demethylation and N4-acetylation of sulphadimethoxine by the turtle Pseudemys scripta elegans.
After an oral dose of 350 mg of sulphadimethoxine, the turtle Pseudemys scripta elegans O-dealkylates sulphadimethoxine at the 2- and 6-position at 38% and 19% respectively, the 2-position being favoured. Acetylation of sulphadimethoxine and its hydroxy metabolites occurs for 57.4%.
Vree
T B
TB
Department of Clinical Pharmacy, Sint Radbound Hospital, Nijmegen, The Netherlands.
Vree
J B
JB
Beneken Kolmer
N
N
Hekster
Y A
YA
Shimoda
M
M
Nouws
J F
JF
Yoshioka
T
T
Hoji
K
K
D000107:Acetylation; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D013412:Sulfadimethoxine / Q000493:pharmacokinetics*; D014426:Turtles / Q000378:metabolism*
D013412:Sulfadimethoxine