A permanent dopamine receptor up-regulation in the ovariectomized rat.
Although a permanent supersensitivity to dopamine agonists can be induced by lesions of the nigrostriatal dopamine tract, the ovariectomized rat is the first animal model of a permanent hypersensitivity to dopamine agonists in which the neurons survive. This permanent behavioral hypersensitivity to direct acting dopamine agonists is accompanied by an increase in D2 dopamine receptor density in the striatum.
Gordon
J H
JH
Research Service, Hines V. A. Hospital, IL 60141.
Fields
J Z
JZ
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D005260:Female; D007700:Kinetics; D010052:Ovariectomy; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology*; D013134:Spiperone / Q000378:metabolism; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D011954:Receptors, Dopamine; D013134:Spiperone; D001058:Apomorphine