[Microsurgical catheterization of the intrathecal space in the rat for chronic infusion of drugs].
An original technique for placement of intrathecal catheters suitable for drug administration is described. For implantation a microsurgical laminectomy is carried out, opening the dura mater and placing the catheter under surgical microscope control. Only a few instrumentation is mandatory. The mean time for this surgery was between 15 and 20 minutes. A 10% of the animals operated on developed neurological deficits and must be dropped. The mortality rate was a 5%. No catheter malfunctions were found.
González-Darder
J M
JM
Gómez-Cárdenas
E
E
Gil-Salú
J L
JL
D000818:Animals; D002404:Catheterization / Q000379:methods*; D005069:Evaluation Studies as Topic; D007278:Injections, Spinal / Q000379:methods*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D051381:Rats; D011919:Rats, Inbred Strains
Cateterización microquirúrgica del espacio intratecal de la rata para infusión crónica de fármacos.