[A clinico-pathological study of squamous cell carcinomas of the sino-nasal cavity metaplasia and dysplasia].
We report a clinicopathological study in 193 cases with squamous cell carcinoma (SCC) in the sino-nasal cavity. Squamous metaplasia were found in 62.6% and squamous dysplasia in 25.3% of the SCC cases. These lesions seem to be important factors related with cancer development. Etiologically, metaplasia was found to be related with age and sex (male-dominant), but not with smoking and history of sinusitis. Chronic inflammation, papillary or stratified proliferation and reserved cell hyperplasia were considered as factors inducing squamous metaplasia in review of pathological specimens. We infered from the distribution pattern of cytokeratin that it might occur serial changes from metaplasia, dysplasia, CIS to microinvasive carcinoma, whose phenomenon was commonly seen in cases of uterus squamous cell carcinoma.
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Ogawa
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000473:pathology*; D010255:Paranasal Sinus Neoplasms / Q000453:epidemiology / Q000473:pathology*; D012737:Sex Factors