New versatile restraining device for use with rats in pharmacokinetic or pharmacological studies involving chronically implanted cannulae or electrodes.
A new design for a rat restraining device is described. Features of the device include facilities to allow the accommodation of rats of a very wide weight range and to maximize its convenience in use in a variety of procedures including the collection of blood, feces, and urine. The restrainer is designed to minimize stress in the rat in the course of pharmacokinetic or pharmacological studies. The device is particularly useful for studies involving chronically cannulated animals.
Lewis
A
A
Department of DMPK, Smith Kline and French Research Ltd., Welwyn, Herts U.K.
Long
A
A
Griffiths
R
R
D000818:Animals; D002404:Catheterization; D004567:Electrodes, Implanted; D010599:Pharmacokinetics; D010600:Pharmacology / Q000295:instrumentation*; D051381:Rats; D012149:Restraint, Physical / Q000295:instrumentation*