The human interleukin-1 alpha gene is located on the long arm of chromosome 2 at band q13.
Interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) are two biochemically distinct, but distantly related, polypeptidic cytokines that play a key role in inflammation, immunologic reactions, and tissue repair. Recently, it has been shown that IL-1 alpha is identical to hematopoietin 1, which was described as a hematopoietic growth factor acting on early progenitor cells in synergy with other hematopoietic growth factors. In this report we discuss our use of in situ hybridization on human prometaphase cells with a human IL-1 alpha cDNA probe to localize the human IL-1 alpha gene on the proximal part of the long arm of chromosome 2 at band q13, in the same chromosomal region as the IL-1 beta gene.
Department of Hematology and Cell Biology, Regional Cancer Center, Marseille, France.
M
M
Lafage
N
N
Maroc
P
P
Dubreuil
R
R
de Waal Malefijt
M J
MJ
Pébusque
Y
Y
Carcassonne
P
P
Mannoni
D002871:Chromosome Banding; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D004247:DNA / Q000302:isolation & purification; D015263:Deoxyribonucleases, Type III Site-Specific; D005796:Genes; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D009693:Nucleic Acid Hybridization
D007375:Interleukin-1; D004247:DNA; D015263:Deoxyribonucleases, Type III Site-Specific