[Ultrastructural changes in the interneuronal contacts of the upper layers of the cerebral cortex in cats when aminazine is applied].
The fine structure of upper layer of axodendritic synapses of the cat cerebral cortex was studied during 10, 45 and 90 minute applications of aminazine, and also 2.5 and 5 hours after the cessation of the 90 minute application. During the 10 and 45 minute applications no clear-cut changes are observed in the ultrastructure of the synapses. 90 minutes after the onset of application osmophilic changes are enhanced in the pre- and postsynaptic areas. During the drug application, the number of synaptic vesicles and the area of the axonal terminals decrease. The above morphological changes are reversible: restoration of the number of synaptic vesicles commences, but the area of the terminal is still shrunken.
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Kutateladze
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000648:ultrastructure; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects / Q000648:ultrastructure*; D002746:Chlorpromazine / Q000494:pharmacology*; D003712:Dendrites / Q000187:drug effects / Q000648:ultrastructure; D004569:Electroencephalography; D007395:Interneurons / Q000187:drug effects / Q000648:ultrastructure*; D008854:Microscopy, Electron; D013569:Synapses / Q000187:drug effects / Q000648:ultrastructure; D013997:Time Factors
D002746:Chlorpromazine
Izmeneniia ul'trastruktury mezhneĭronal'nykh kontaktov verkhnikh sloev kory golovnogo mozga koshek pri applikatsii aminazina.