Ethacizin metabolism in humans.
1. The major metabolites of ethacizin (ethyl 10-[3-diethylaminopropionyl]phenothiazine-2-carbamate) have been isolated from human urine by h.p.l.c. and identified by determination of u.v., i.r., n.m.r. and mass spectra and comparison with spectra of synthetic standard compounds. 2. The pathways of metabolism of ethacizin include N-de-ethylation, sulphoxidation, N-10 amide hydrolysis, aromatic hydroxylation and conjugation.
I.M. Sechenov Medical Institute, Moscow Research Institute of Pharmacology, USSR.
V L
VL
Beloborodov
A P
AP
Rodionov
N A
NA
Tyukavkina
A V
AV
Klimov
N V
NV
Kaverina
Kolesnik YuA
A N
AN
Gritsenko
V P
VP
Lesina
D000889:Anti-Arrhythmia Agents / Q000378:metabolism* / Q000652:urine; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006868:Hydrolysis; D010084:Oxidation-Reduction; D010640:Phenothiazines / Q000378:metabolism* / Q000652:urine
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; C046818:ethacizine