Testing a combined radiation protection modality: chemical protector and local shielding.
The impact of combined radiation protection upon damage to critical organs-spleen, small intestine, and bone marrow was studied in adult rat males 3 days after whole-body exposure to 9.5 Gy gamma-ray dose. Adeturone, the chemical radioprotector used, was administered intraperitoneally at 1/17 of its LD50 dose. Local shielding of the abdomino-lumbal region was accomplished using a lead ring providing on average 28-30% attenuation of radiation exposure. This degree of physical abdomino-lumbal protection combined with adeturone (50 mg/kg) pretreatment resulted in mutual enhancement of the components' action, expansion of the chemical agent's therapeutic range, providing a combination with improved overall antiradiation properties.
Minkova
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M
Baldzhijska
M
M
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D005069:Evaluation Studies as Topic; D007854:Lead; D008297:Male; D011835:Radiation Protection; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D000338:beta-Aminoethyl Isothiourea / Q000031:analogs & derivatives / Q000627:therapeutic use
D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D007854:Lead; C012704:Adeturon; D000255:Adenosine Triphosphate