[Effect of immunosuppression on the development and outcome of an acute infection in mice caused by administration of the Lassa virus].
In experimental infection of mice with Lassa virus, the infectious virus could be detected in all the organs and brain tissues tested. Histopathological lesions were demonstrated in cerebral and spinal cord tissues only. Roentgen irradiation in a dose of 500 R and cyclophosphamide protected mice against a lethal Lassa virus dose. Cyclosporin A in various doses exerted no effect on the outcome of the acute infection. The adoptive transfer of splenocytes from mouse donors inoculated intraperitoneally prevented the development of lethal disease symptoms and death of mice-recipients. It is suggested that immunocompetent cells are involved in the development and outcome of experimental infection of mice with Lassa virus.
Barkar
N D
ND
Mar'iankova
R F
RF
Godneva
A T
AT
Grigor'eva
L V
LV
Zudin
B I
BI
D000208:Acute Disease; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D003524:Cyclosporins / Q000494:pharmacology; D007108:Immune Tolerance / Q000187:drug effects / Q000528:radiation effects; D007111:Immunity, Cellular / Q000187:drug effects / Q000528:radiation effects; D007116:Immunization, Passive; D007835:Lassa Fever / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D007836:Lassa virus / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology / Q000528:radiation effects; D051379:Mice; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D014779:Virus Replication / Q000187:drug effects / Q000528:radiation effects
D003524:Cyclosporins; D003520:Cyclophosphamide
Vliianie immunosupressii na razvitie i iskhod ostroĭ infektsii, vyzyvaemoĭ u mysheĭ vvedeniem virusa Lassa.