Preparation of beta-aminomethyl-beta-benzoylpropionic acids and related cis beta-aminomethyl-gamma-phenyl-gamma-butyrolactones as potential antibacterial agents.
The synthesis of beta-aminomethyl-beta-benzoylpropionic acids (V) and beta-aminomethyl-gamma phenylbutyrolactones (VI) is described. The cis stereochemistry of compounds VI was unambiguously established by NOE experiments carried out with Vla. Antibacterial activity was studied; MIC of each derivate was determined by agar dilution in Muller-Hinton medium and application of Steers' replicator.
Santana
L
L
Cortizo
L
L
Uriarte
E
E
Garcia-Dominquez
N
N
Raviña
E
E
Garrido
M J
MJ
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects*; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011422:Propionates / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007783:Lactones; D011422:Propionates