A study of the mechanisms of chloroquine retinopathy. II. Chloroquine effect on protein synthesis of retina.
The influence of chloroquine on protein synthesis in rabbit retina has been studied. It is shown that chloroquine inhibits rhodopsin synthesis and the renewal of rod outer segment membranes.
Ivanina
T A
TA
Hilmholtz Institute of Ophthalmology, USSR Academy of Science, Moscow.
Sakina
N L
NL
Lebedeva
M N
MN
Borovjagin
V L
VL
D000818:Animals; D001345:Autoradiography; D002738:Chloroquine / Q000633:toxicity*; D005404:Fixatives; D005614:Freeze Fracturing; D010786:Photoreceptor Cells / Q000378:metabolism; D011817:Rabbits; D012160:Retina / Q000378:metabolism* / Q000648:ultrastructure; D012168:Retinal Pigments / Q000096:biosynthesis*; D012243:Rhodopsin / Q000096:biosynthesis*
D005404:Fixatives; D012168:Retinal Pigments; D002738:Chloroquine; D012243:Rhodopsin