[Effect of trimecaine on myocardial contractility and the rhythmoinotropic properties of the myocardium in hypoxia].
In the papillary muscles from 14 adult rats and myocardial specimens from 14 newborn ones, trimecaine in doses of 1.10(-6) and 5.10(-6) g/ml produced a dose-dependent negative inotropic effect, reversed the rhythmoinotropic correlation into a negative one and minimized the efficiency of postextrasystolic potentiation. Trimecaine in the former dose reduced hypoxic damage of myocardial specimens in the both groups as reflected by a smaller amplitude of hypoxic contracture and better contractility recovery following a hour hypoxia. It is suggested that reduction in hypoxic contracture and damage to the myocardium occur in the presence of trimecaine from limited Ca2+ entry into myocytes via the Na-Ca turnover mechanism.
P B
PB
Tsy'vian
V A
VA
Babaev
Effect
D000083:Acetanilides / Q000494:pharmacology*; D000818:Animals; D003470:Culture Media; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects* / Q000503:physiopathology; D051381:Rats; D014288:Trimecaine / Q000008:administration & dosage / Q000494:pharmacology*
D000083:Acetanilides; D003470:Culture Media; D014288:Trimecaine
Deĭstvie trimakaina na sokratimost i ritmoinotropnye svoĭstva miokarda pri gipoksii.