Heparinizable segmented polyurethanes containing poly-amidoamine blocks.
A poly-ether-urea-urethane was synthesized by copolymerization of 4,4'-diphenylmethanediisocyanate (MDI), propanediamine, and poly-oxytetra-methylene glycol (M.W. 1000). Two other corresponding copolymers were also synthesized by adding amino terminated poly-amidoamine macromonomers, purposely synthesized, so as to insert relatively small amounts (6 and 15 weight %) of two types of poly-amidoamine segments in the final product. Of the three copolymers several physicochemical and mechanical properties have been determined, and their heparin adsorption ability, blood compatibility, and cytotoxicity evaluated.
Dept. Chimica Industriale e Ingegneria Chimica G. Natta, Milano, Italy.
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D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004987:Ethers / Q000138:chemical synthesis / Q000494:pharmacology; D006493:Heparin; D007202:Indicators and Reagents; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013718:Tensile Strength; D014508:Urea / Q000138:chemical synthesis* / Q000494:pharmacology
D001672:Biocompatible Materials; D004987:Ethers; D007202:Indicators and Reagents; D011108:Polymers; D011140:Polyurethanes; D014508:Urea; D006493:Heparin