Penetration of doxycycline into cerebrospinal fluid in patients treated for suspected Lyme neuroborreliosis.
Twelve patients were treated orally with 100 mg of doxycycline twice a day (b.i.d.) and 10 patients were treated with 200 mg b.i.d. for suspected tick-borne neuroborreliosis (Lyme borreliosis). At 5 to 8 days after the start of therapy, the mean concentrations in serum were 4.7 micrograms/ml for the doxycycline dose of 100 mg b.i.d. and 7.5 micrograms/ml for 200 mg b.i.d., 2 to 3 h after the last drug administration. The corresponding levels for cerebrospinal fluid were 0.6 and 1.1 micrograms/ml. Since a doxycycline concentration in cerebrospinal fluid above the estimated MIC for Borrelia burgdorferi (0.6 to 0.7 microgram/ml) is wanted in patients treated for severe neuroborreliosis, the higher dose is preferable.
Department of Infectious Diseases, University of Göteborg, Sweden.
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L
Dotevall
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L
Hagberg
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004318:Doxycycline / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D006801:Humans; D008193:Lyme Disease / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D008875:Middle Aged
D004318:Doxycycline