A good outcome pregnancy in a patient with paroxysmal nocturnal hemoglobinuria.
In this report, the maternal and fetal risks in a patient with paroxysmal nocturnal hemoglobinuria (PNH) were evaluated. A patient with PNH carried a pregnancy to successful delivery, with a healthy male infant, and suffered from postpartum cerebral subcortical, but not hepatic, thrombosis followed by recovery. An elevation of serum levels of lactate dehydrogenase isoenzyme, alpha-hydroxybutyrate dehydrogenase, was observed during pregnancy. The level was ameliorated to the non-pregnant level by delivery. However, hemoglobin concentrations during pregnancy and post-partum were at least 8 g/dl. This is a first report that shows tight coupling between an onset of intravenous hemolysis and pregnancy. The management of pregnancies in such patients is also discussed.
Takagi
H
H
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
Imai
A
A
Kawabata
I
I
Sumi
H
H
Shiraki
S
S
Tamaya
T
T
D000328:Adult; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000652:urine*; D011256:Pregnancy Outcome