Development of new pharmacological agents for epilepsy: lessons from the kindling model.
The greatest value of the kindling model for new therapy of epilepsy almost certainly lies in elucidating the molecular basis of its development and persistence. Such an understanding may provide a foundation for therapies aimed at prevention or perhaps even cure of some forms of human epilepsy.
McNamara
J O
JO
Duke University Medical Center, Durham, North Carolina.
D000596:Amino Acids / Q000627:therapeutic use; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy*; D007696:Kindling, Neurologic; D008959:Models, Neurological; D009638:Norepinephrine / Q000627:therapeutic use
D000596:Amino Acids; D000927:Anticonvulsants; D001569:Benzodiazepines; D009638:Norepinephrine