Kinetics of voltage-induced conductance increases in the outer mitochondrial membrane.
The kinetics of the increase in conductance in the outer mitochondrial membrane induced by patch-clamping at various negative potentials (pipette inside negative) are reported. The changes are biphasic, a rapid increase is followed by a slowly developing larger change. The results can be predicted by a model in which an initial activation of channels is followed by their assembly into highly conducting channels. The model suggests that five to seven activated subunits form each high-conductance channel.
Department of Biological Sciences, State University of New York, Albany 12222.
K W
KW
Kinnally
H
H
Tedeschi
C A
CA
Mannella
H L
HL
Frisch
D000818:Animals; D004553:Electric Conductivity; D007425:Intracellular Membranes / Q000502:physiology*; D007700:Kinetics; D008433:Mathematics; D008564:Membrane Potentials; D051379:Mice; D008928:Mitochondria / Q000502:physiology*; D008954:Models, Biological