[Cross-reactivity of HLA antigens of the donor and patient--a cause of unsuccessful thrombocyte transfusion in patients with HLA antibodies].
In the microlymphocytotoxic test, specific HLA sera reacted positively with 74.74% of 99 examined samples of lymphocytes which failed to have corresponding HLA antigens yet contained HLA antigens cross-reacting with the given HLA antibody. In the serum of some patients HLA antibodies were established against HLA antigens cross-reacting with the antigens of the patient. The results show that it is not suitable to select thrombocyte and leukocyte donors on the basis of cross-reacting antigens. Therapy of patients with HLA antibodies may be clinically unsuccessful and even result in posttransfusion reaction. Patients who do not have HLA antibodies may develop them.
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D000961:Antilymphocyte Serum / Q000276:immunology*; D001782:Blood Donors; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D017713:Platelet Transfusion; D065227:Transfusion Reaction
D000961:Antilymphocyte Serum; D006680:HLA Antigens
Krízová reaktivita HLA-antigenů dárce a nemocného--prícina neúspĕchů transfúzí trombocytů nemocných s HLA-protilátkami.