Solubility of I-653, sevoflurane, isoflurane, and halothane in plastics and rubber composing a conventional anesthetic circuit.
This study defines some characteristics of a standard anesthetic circuit that may impede anesthetic induction and recovery with I-653, sevoflurane, isoflurane, and halothane. Partition coefficients for anesthetic circuit components (masks, bellows, bags, airways, and circuit tubes) consistently ranked halothane greater than isoflurane greater than sevoflurane greater than I-653, suggesting a reverse order of washin and washout rates for an anesthetic circuit constructed from similar components. Consistent with this prediction, the concentrations of I-653 increased and decreased more rapidly than those of the other agents at any flow rate during washin (0.5, 1, or 2 L/min gas inflow rates) or washout (1, 3, or 5 L/min) in a conventional anesthetic circuit. The rates of change in I-653 concentration closely approximated the maximal possible theoretical rates. Our results suggest that absorption of I-653 by circuit components or soda lime should not hinder induction of or recovery from anesthesia.
Department of Anesthesia, University of California, San Francisco 94143-0464.
A G
AG
Targ
N
N
Yasuda
E I
EI
Eger
D000327:Adsorption; D000769:Anesthesia, Inhalation / Q000295:instrumentation*; D000777:Anesthetics; D017610:Calcium Compounds; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D000077335:Desflurane; D004058:Diffusion; D004209:Disposable Equipment; D004987:Ethers; D006221:Halothane; D007530:Isoflurane / Q000031:analogs & derivatives*; D008738:Methyl Ethers; D010087:Oxides; D010969:Plastics; D011095:Polyethylenes; D012212:Rheology; D012408:Rubber; D000077149:Sevoflurane; D012972:Sodium Hydroxide; D012995:Solubility
D000777:Anesthetics; D017610:Calcium Compounds; D004987:Ethers; D008738:Methyl Ethers; D010087:Oxides; D010969:Plastics; D011095:Polyethylenes; D000077149:Sevoflurane; C004569:soda lime; D012972:Sodium Hydroxide; D012408:Rubber; D000077335:Desflurane; D007530:Isoflurane; D006221:Halothane