WS-9659 A and B, novel testosterone 5 alpha-reductase inhibitors isolated from a Streptomyces. II. Structural elucidation of WS-9659 A and B.
On the basis of spectroscopic and chemical evidence, the structures of WS-9659 A and B isolated as inhibitors of testosterone 5 alpha-reductase from a Streptomyces have been established as 1 and 2, respectively. The reductase inhibitory activities of the derivatives 5 and 6, and degradation products 3 and 8 were considerably less active and substantially inactive, respectively.
Exploratory Research Laboratory, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
O
O
Nakayama
N
N
Shigematsu
A
A
Katayama
S
S
Takase
S
S
Kiyoto
M
M
Hashimoto
M
M
Kohsaka
D058891:5-alpha Reductase Inhibitors; D000107:Acetylation; D000900:Anti-Bacterial Agents; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010619:Phenazines; D012972:Sodium Hydroxide
D058891:5-alpha Reductase Inhibitors; D000900:Anti-Bacterial Agents; D010619:Phenazines; C060460:lavanducyanin; C060647:WS 9659 B; D012972:Sodium Hydroxide