[Experimental renal insufficiency in rabbits produced by the intrarenal injection of cyanoacrylic ester].
Through a percutaneous intrarenal injection of 2 ml cyanoacrylic ester to each kidney, acute renal failure was induced in 10 experimental rabbits. Seven of the animals died as a consequence of uremia before a period of 64 hours. The other three remained alive for 96 hours although suffering from stable renal failure. Cyanoacrylic ester solidifies immediately after injection, leading to a hardened body which fills the renal pelvis, ureters and also the renal vessels. Each injection induces hydronephrosis and necrotic-hemorrhagic lesions, and infarcts in the case of vascular injection. With this simple technique immediate acute renal failure can be obtained experimentally without causing trauma or involving extrarenal structures.
A
A
Jimeno Carruez
F
F
de Alvaro
E
E
Ibañez
V
V
Pérez Díaz
E
E
Largo
F
F
Anllo
R
R
Gómez de la Torre
O
O
Ortiz
D000179:Acrylates / Q000633:toxicity*; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000269:Adhesives / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D003487:Cyanoacrylates / Q000008:administration & dosage / Q000633:toxicity*; D007267:Injections; D008297:Male; D008689:Methacrylates / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits
D000179:Acrylates; D000269:Adhesives; D003487:Cyanoacrylates; D008689:Methacrylates; C038690:Loctite
Insuficiencia renal experimental en conejos por inyección intrarrenal de ester cianoacrílico.