Ultrastructural correlates of functional relationships between nigral dopaminergic or cortical afferent fibers and neuropeptide Y-containing neurons in the rat striatum.
This study examines the ultrastructural relationships established by the nigrostriatal dopaminergic and the corticostriatal afferent fibers with neuropeptide Y (NPY)-containing neurons in the rat striatum. By means of dual immunolabeling procedures using peroxidase conjugated F(ab) fragments and 125I-labeled protein A, direct appositions and morphologically defined synaptic contacts of the symmetrical type were visualized between tyrosine hydroxylase-labeled nerve terminals and NPY-labeled neurons. After deafferentation of the striatum from its cortical input direct appositions and asymmetrical synaptic contacts were evidenced between characteristic degenerative boutons and NPY-positive neurons in the striatum. These results suggest that striatal NPY interneurons undergo direct influence from both nigrostriatal dopaminergic and corticostriatal neuronal systems.
Centre de Microscopie Electronique, Faculté de Médecine, Marseilles, France.
J
J
Vuillet
L
L
Kerkerian
P
P
Kachidian
O
O
Bosler
A
A
Nieoullon
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism* / Q000648:ultrastructure; D004298:Dopamine / Q000378:metabolism* / Q000502:physiology; D005260:Female; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009434:Neural Pathways / Q000378:metabolism; D009478:Neuropeptide Y / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000378:metabolism* / Q000648:ultrastructure
D009478:Neuropeptide Y; D004298:Dopamine