Feasibility of a short term severely restricted sodium diet with counselling support.
For the purpose of short term clinical trials previous studies have made use of metabolic kitchens to provide severely restricted sodium diets. We evaluated the feasibility of administering a 5-day severely restricted (22 mmol) sodium diet on an outpatient basis with counselling support, outside a metabolic unit. In 13 highly-motivated volunteers, 24-h urinary sodium excretion fell from 128.5 +/- 11.9 on a normal diet to 19.2 +/- 2.88 mmol per day and plasma sodium dropped from normal diet to 19.2 +/- 2.88 mmol per day and plasma sodium dropped from 140 +/- 0.41 to 137 +/- 0.78 mmol/L, showing that such an approach is effective.
Liver Unit, King's College Hospital, Denmark Hill, London, UK.
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MZ
Panos
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Williams
D000328:Adult; D003376:Counseling; D004039:Diet, Sodium-Restricted; D005240:Feasibility Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D012964:Sodium / Q000652:urine
D012964:Sodium