Leucocyte superoxide dismutase levels in acute and chronic leukemias.
Superoxide dismutase "SOD" enzyme levels in leucocytes of patients with acute and chronic leukemia, were measured by using Misra and Fridovich's epinephrine method. In all types of leukemia, the SOD levels were found to be significantly higher than normals. However, these levels decreased to normal in remission. No relationship was found between the SOD level and types of leukemia. The absence of relationship between the increase in SOD level and various clinical parameters suggests that this increase is the result of a disturbed gene expression in the stem cells. Hence it is of interest to ascertain the effect of the chemotherapy leading to the normalization of the SOD levels.
Kökoğlu
E
E
Department of Biochemistry, Cerrahpaa Medical Faculty of Istanbul University, Turkey.
Aktuğlu
G
G
Belce
A
A
D000208:Acute Disease; D002908:Chronic Disease; D006801:Humans; D007938:Leukemia / Q000201:enzymology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000201:enzymology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000201:enzymology; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology; D007962:Leukocytes / Q000201:enzymology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology; D013482:Superoxide Dismutase / Q000097:blood*
D013482:Superoxide Dismutase