Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats.
The temporal requirements for theophylline-induced upregulation of A1 adenosine receptors and elevation of seizure threshold were examined. Chronic theophylline exposure (75 mg/kg twice daily) elicited a significant upregulation of [3H]cyclohexyladenosine ([3H]CHA) binding sites following 7 and 14 days of treatment. Alterations in seizure threshold followed a similar temporal pattern of development. The reversibility of theophylline-induced upregulation of high affinity [3H]CHA binding sites was complete at 10 days following cessation of theophylline administration, while the alteration of seizure threshold required 21 days to return to control values.
College of Pharmacy, Oregon State University, Corvallis 97331.
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Sanders
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Murray
D000241:Adenosine / Q000031:analogs & derivatives / Q000378:metabolism; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011983:Receptors, Purinergic / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D012640:Seizures / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D013806:Theophylline / Q000494:pharmacology*; D013997:Time Factors
D011983:Receptors, Purinergic; C027513:N(6)-cyclohexyladenosine; D013806:Theophylline; D000241:Adenosine; D001640:Bicuculline