Human gastric emptying and colonic filling of solids characterized by a new method.
Our first aim was to compare 111In-labeled Amberlite IR-12OP resin pellets and 131I-labeled fiber in the assessment of gastric and small bowel transit and colonic filling in healthy humans. Both radiolabels were highly stable for 3 h in an in vitro stomach model and remained predominantly bound to solid phase of stools collected over 5 days [90.5 +/- 2.1 (SE)% for 131I and 87.4 +/- 1.4% for 111In). The lag phase of gastric emptying was shorter for 111In-pellets (30 +/- 11 min compared with 58 +/- 12 min for 131I-fiber, P less than 0.05). However, the slope of the postlag phase of gastric emptying and the half time of small bowel transit were not significantly different for 111In-pellets and 131I-fiber. Filling of the colon was characterized by bolus movements of the radiolabel (10-80% range, 26% mean) followed by plateaus (periods of no movement of isotope into colon lasting 15-120 min, range; 51 min, mean). Half of the bolus movements occurred within 1 h of the intake of a second meal. Thus 111In-labeled Amberlite pellets provide an excellent marker for the study of gastric and small bowel transit and colonic filling in humans. The ileum acts as a reservoir and transfers boluses of variable sizes into the colon, often soon after the intake of a subsequent meal.
Camilleri
M
M
Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905.
Colemont
L J
LJ
Phillips
S F
SF
Brown
M L
ML
Thomforde
G M
GM
Chapman
N
N
Zinsmeister
A R
AR
D000328:Adult; D003106:Colon / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D005746:Gastric Emptying; D005766:Gastrointestinal Contents; D005772:Gastrointestinal Transit; D006801:Humans; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013270:Stomach / Q000000981:diagnostic imaging / Q000502:physiology
D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes