[Comparative evaluation of the levels of water-soluble glial fibrillary acidic protein in the human brain in the normal state and in schizophrenia].
The concentration of water-soluble glial fibrillary acidic protein was measured in several regions of human brains (12 schizophrenic patients and 13 patients without any signs of mental disease) using ELISA technique. The content of this protein was lower in thalamus and gyrus cinguli in schizophrenics as compared to normals (p less than 0.01). The protein showed no correlation with sex, age and the terms of autopsy (5 to 7 h after death). The findings suggest that decreasing concentration of the protein might reflect the changes of its synthesis, posttranslational modifications, assembling and disassembling of glial filaments and possibly the effect of psychotropic drugs.
Tursunova
Iu D
IuD
Kliushnik
T P
TP
Burbaeva
G Sh
GSh
D000368:Aged; D001921:Brain / Q000378:metabolism*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000172:deficiency / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012559:Schizophrenia / Q000378:metabolism*; D012995:Solubility; D014867:Water
D005904:Glial Fibrillary Acidic Protein; D014867:Water
Sravnite'lnaia otsenka soderzhaniia vodorastvorimogo glia'lnogo fibrilliarnogo kislogo belka v golovnom mozge cheloveka v norme i pri shizofrenii.