[Clinical observation and experimental study on the treatment of diarrhea due to spleen deficiency with jianpiling].
The clinical and experimental results of Jianpiling for treating diarrhea due to Spleen deficiency were reported in this paper. 268 cases in the treatment group were treated with Jianpiling, 8 tablets three times daily for a consecutive period of 40-60 days. The curative rate and the total effective rate were 63.4% and 98.5% respectively. 75 cases in the control group were treated with SASP or Diphenoxylatum Co., the curative rate and the total effective rate being 38.7% and 94.7% respectively. The difference of the curative rate between the two groups was statistically significant (P less than 0.001). The excretory rate of D-xylose demonstrated that Jianpiling could increase the resorptive function of small intestine. The experiment on isolated small intestine of rabbits showed that Jianpiling could strikingly inhibit the peristalsis of isolated jejunum and ileum. The effect of relieving spasm of the intestine and alleviating pain was taken by antagonising the exictative function of M-receptor for acetylcholine and directly inhibiting the intestinal smooth muscle.
Z S
ZS
Chen
D B
DB
Jia
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010528:Peristalsis / Q000187:drug effects; D011817:Rabbits; D013158:Splenic Diseases / Q000150:complications; D013607:Tablets
D004365:Drugs, Chinese Herbal; D013607:Tablets