Acid catalyzed hydrolysis of a series of zopiclone analogues.
The pKa values of acid-base equilibria involved in the protonation of zopiclone and analogues are determined by UV-visible absorption spectrometry and pH-metry. Hydrogen ion catalysis is evidenced in the carbamate hydrolysis.
Largeron
M
M
Laboratoire de Chimie Analytique, U.A. 484 au C.N.R.S., Faculté de Pharmacie, Paris, France.
Fleury
M B
MB
D053961:Azabicyclo Compounds; D002021:Buffers; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D006207:Half-Life; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D010879:Piperazines / Q000032:analysis* / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet
D053961:Azabicyclo Compounds; D002021:Buffers; D010879:Piperazines; C515050:zopiclone