Synthesis of novel benzylimidazolines possessing antihypertensive and sedative activity.
In the course of a study to produce new long acting local anaesthetics, a number of novel benzylimidazoline derivatives were synthesised and tested for local anaesthetic activity, vasoconstrictor effect and ease of displacement of p-aminoclonidine. The synthesis is shown in Scheme 1.- The synthesised compounds do not exhibit a significant local anaesthetic effect, but display an antihypertensive action with considerable alpha-2 adrenoceptor binding affinity.
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D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001593:Benzyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains
D000959:Antihypertensive Agents; D001593:Benzyl Compounds; D006993:Hypnotics and Sedatives; D007093:Imidazoles