[Effects of anti-tissue immune sera on the contractile response of cells isolated from smooth muscle of the pyloric antrum].
The effect of anti-tissue antisera on the contractile response of isolated smooth muscle cells from rabbit antrum has been investigated. Anti-stomach (SAE), anti-colon (SAC) and anti-diencephale (SAD) antisera induced a dose-dependent contraction is isolated cells, whereas both non-immune serum and antisera obtained by immunization with other foetal tissues were ineffective. Proglumide, the well known gastrin antagonist, similarly inhibited both gastrin- and SAE, SAC, SAD antisera-induced contraction of isolated smooth muscle cells.
Labor für Pharmakologische Biochemie, CNRS LP 8402-INSERM U-249, Pharmazeutische Fakultät, Montpellier, Frankreich.
S
S
Ammor
R
R
Magous
J P
JP
Bali
P
P
Mingard
G
G
Combépine
D000818:Animals; D003106:Colon / Q000276:immunology; D004027:Diencephalon / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D007106:Immune Sera / Q000008:administration & dosage / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000166:cytology / Q000187:drug effects*; D011377:Proglumide / Q000494:pharmacology; D011706:Pyloric Antrum / Q000166:cytology; D011817:Rabbits; D013270:Stomach / Q000276:immunology
D007106:Immune Sera; D011377:Proglumide
Die Auswirkungen der Antigewebsimmunseren auf die Kontraktion von aus der glatten Muskulatur des Antrum pyloricum isolierten Zellen.