Synthesis, antilipidemic and platelet antiaggregatory activity of 2-aminobenzimidazole amide derivatives.
The synthesis and preliminary pharmacological evaluation of 2-aminobenzimidazole amide derivatives are reported. None of these compounds showed antilipidemic or platelet antiaggregatory activity comparable to that of drugs used in therapy.
Istituto di Chimica Farmaceutica, Università di Pisa, Italy.
P
P
Caroti
C
C
Ceccotti
F
F
Da Settimo
G
G
Primofiore
J S
JS
Franzone
M C
MC
Reboani
C
C
Cravanzola
D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D001562:Benzimidazoles; D000960:Hypolipidemic Agents; D010975:Platelet Aggregation Inhibitors