Effects of vinyl chloride on liver function of exposed workers, evaluated by measurements of plasma clearance of the 99mTc-N-2,4-dimethylacetanilido-iminodiacetate complex.
In 77 males exposed occupationally to vinyl chloride (VC), the plasma clearance (Cl) of 99mTc-N(2,4-dimethylacetanilido)iminodiacetate ('HEPIDA' complex) was determined. The results were juxtaposed with a scaled assessment of liver parenchyma performance based upon clinical examination and a series of biochemical tests. Detection of the diagnosable damage of liver parenchyma by means of the reduced clearance was sensitive (90%) at the reasonable specificity of 74%. Probability of exclusion of liver damage in patients with the clearance above 240 ml min-1 1.73 m-2 amounted to 92%. There was a significant correlation between degree of exposure to VC and the frequency of low clearance values. It appears that the periodic determination of the 99mTc-HEPIDA clearance in workers exposed to VC allows the assessment of incipient liver damage and signals the need for prophylactic measures.
Department of Nuclear Medicine, Medical Academy, Lodz, Poland.
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Studniarek
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Durski
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Liniecki
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Brykalski
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Poznańska
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Głuszcz
D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology*; D006801:Humans; D007098:Imino Acids; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000503:physiopathology; D009942:Organometallic Compounds; D013667:Technetium; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid; D014752:Vinyl Chloride / Q000633:toxicity*; D014753:Vinyl Compounds / Q000633:toxicity*
D007098:Imino Acids; D009942:Organometallic Compounds; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid; D014753:Vinyl Compounds; D013667:Technetium; D014752:Vinyl Chloride