The effect of diclofenac sodium on renal function.
The effects of diclofenac sodium on the kidneys were studied during 4 1/2 hours in eight patients with normal renal function. Urinary output decreased within 10 min after the injection, and maximally by 80%. The renal plasma flow and the glomerular filtration rate initially diminished significantly, by 35%, but began to increase after only 2 hours. The dominant and persistent effect was reduction of free water clearance, with maximum fall from 5.9 to 0.08 ml/min after 2 1/2 hours. The long-lasting increased tubular reabsorption of water probably is important for the lowered intrapelvic pressure that is associated with good analgetic effect of diclofenac in ureteral colic.
Kinn
A C
AC
Department of Urology, Karolinska Hospital, Stockholm, Sweden.
Elbarouni
J
J
Seideman
P
P
Sollevi
A
A
D000328:Adult; D003085:Colic / Q000188:drug therapy; D004008:Diclofenac / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation / Q000187:drug effects; D013997:Time Factors; D014515:Ureteral Diseases / Q000188:drug therapy
D004008:Diclofenac