[Basic studies on optimal intra-arterial infusion rate of cisplatin].
The relationship between platinum concentration in tissues, free CDDP concentration in plasma and infusion rate was investigated in order to determine the optimal intra-arterial infusion rate of CDDP for chemotherapy of cervical carcinoma. Platinum concentrations in uterus were in the same level in the intravenous infusion groups independent of the infusion rate. In the intra-arterial infusion groups, platinum concentrations in the uterus increased as the infusion rate decreased from 24 to 0.8 mg/hr, although Cmax and AUC were decreased. Platinum concentrations in the ovary supplied by another artery were not influenced by the intra-arterial infusion rate. It is suggested that uptake of CDDP in the targeted tissues can be increased by control of intra-arterial infusion rate.
Dept. of Pharmacy, Kumamoto University Hospital.
S
S
Kishimoto
S
S
Fukushima
Y
Y
Hayashi
M
M
Nakano
K
K
Miyazaki
H
H
Okamura
D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D005260:Female; D007261:Infusions, Intra-Arterial / Q000379:methods; D007262:Infusions, Intravenous; D010053:Ovary / Q000378:metabolism; D010984:Platinum / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014599:Uterus / Q000378:metabolism
D010984:Platinum; D002945:Cisplatin