A method to increase recovery of fentanyl from urine.
Fentanyl, a highly lipophilic drug (pk(a) 7.7), is a common drug of abuse. The current standard techniques to detect fentanyl in urine have low recovery rates and poor sensitivity. We report a modified solvent extraction technique that can recover between 63 and 86% of the drug with a detection limit of 0.2 ng/10 ml of urine. In addition, we report the duration of urinary fentanyl excretion in 11 adolescent patients administered either low (less than 10 mg/kg) or high (20-40 mg/kg) doses of fentanyl as part of anesthesia. The mean duration of urinary fentanyl excretion was similar in the two groups, with duration ranging from 1 to 5 days, and urine fentanyl concentration ranging from 0.1 ng to 10.3 ng/10 ml of urine.
Department of Anesthesiology, Children's Hospital of Pittsburgh, PA 15213-2583.
R L
RL
Stiller
A
A
Scierka
P J
PJ
Davis
D R
DR
Cook
J E
JE
Davis
P M
PM
Winter
D000293:Adolescent; D005283:Fentanyl / Q000652:urine*; D006801:Humans; D007475:Ion Exchange Resins
D007475:Ion Exchange Resins; D005283:Fentanyl