Neocortical transplants grafted into the newborn rat brain demonstrate a blood-brain barrier to macromolecules.
Vascular permeability was examined in fetal neocortical transplants grafted into the cerebral cortex of newborn rats. Methods based on the histochemical labeling of intravenously administered horseradish peroxidase or on the immunocytochemical demonstration of endogenous immunoglobulin showed the presence of a blood barrier within the transplants.
University of Illinois School of Medicine, Chicago, IL 60612.
R S
RS
Swenson
P
P
Shaw
V
V
Alones
G
G
Kozlowski
J
J
Zimmer
A J
AJ
Castro
D000818:Animals; D001812:Blood-Brain Barrier; D002463:Cell Membrane Permeability; D002540:Cerebral Cortex / Q000098:blood supply / Q000637:transplantation*; D004622:Embryo, Mammalian; D006085:Graft Survival; D006735:Horseradish Peroxidase; D051381:Rats
D006735:Horseradish Peroxidase