N-acetyl-beta-glucosaminidase and albuminuria in normal and diabetic pregnancies.
Fourteen diabetic women without signs of nephropathy were examined during pregnancy. Serum fructosamine concentration indicating short-term metabolic control of diabetes was normalized at the beginning of the second trimester and was within the normal limits till the delivery. A gradual increase of N-acetyl-beta-glucosaminidase activity in serum and urine has been found during pregnancy in diabetic and healthy women. No significant differences of N-acetyl-beta-glucosaminidase activities were observed between the above groups. A successive increase of albuminuria during pregnancy was present in diabetic and healthy women with about 10-times higher values at delivery. A significant positive correlation was observed between albuminuria and urinary NAG activity in both groups of pregnant women (r = 0.77). We did not find any deterioration in N-acetyl-beta-glucosaminidase activities and albuminuria in seven diabetic women one year after delivery.
Skrha
J
J
Department of Internal Medicine 3, Faculty of Medicine, Charles University, Prague, Czechoslovakia.
Perusicová
J
J
Sperl
M
M
Bendl
J
J
Stolba
P
P
D000118:Acetylglucosaminidase / Q000097:blood* / Q000652:urine; D000328:Adult; D000419:Albuminuria / Q000097:blood / Q000201:enzymology*; D005260:Female; D019270:Fructosamine; D006595:Hexosamines / Q000097:blood; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D011247:Pregnancy / Q000097:blood* / Q000652:urine; D011254:Pregnancy in Diabetics / Q000201:enzymology* / Q000652:urine
D006595:Hexosamines; D019270:Fructosamine; D006596:Hexosaminidases; D000118:Acetylglucosaminidase