Benthiocarb toxicity on rat brain AChE.
Benthiocarb effect on rat brain acetylcholinesterase (AChE) has been studied to know the toxic effects of benthiocarb on mammalian cholinergic systems. From the study, it has been observed that the inhibition of AChE activity increased with increase in treatment period which is attributed to the cumulative effects of benthiocarb on AChE activity. The kinetic study revealed that there is a slight increase in Km and a marked decrease in Vmax which accounts for the non-competitive inhibition of enzyme during benthiocarb intoxication.
Babu
G R
GR
Department of Zoology, Sri Venkateswara University, Tirupati, India.
Reddy
G R
GR
Chetty
C S
CS
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D007306:Insecticides / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013816:Thermodynamics; D013859:Thiocarbamates / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D013859:Thiocarbamates; C037925:benthiocarb; D000110:Acetylcholinesterase