Lack of teratogenicity of aluminum hydroxide in mice.
The embryotoxic and teratogenic potential of aluminum hydroxide, a therapeutic drug used as an antacid and phosphate binder, was investigated in Swiss mice. Mated female mice were given by gavage daily doses of 0, 66.5, 133 or 266 mg/kg of A1 (OH)3 on gestation days 6 through 15 and killed on gestation day 18. Females were evaluated for body weight gain, food consumption, appearance and behavior, survival rates, and reproduction data. No significant effects attributable to A1(OH)3 were noted in comparison of maternal body weight and food consumption values, appearance and behavior. No treatment-related changes were recorded in the number of total implants, resorptions, the number of live and dead fetuses, fetal size parameters or fetal sex distribution data. Gross external, soft tissue and skeletal examination of the A1-treated fetuses did not reveal differences at any dose in comparison with the controls. Thus, no evidence of maternal toxicity, embryo/fetal toxicity or teratogenicity was observed with A1(OH)3 in mice.
Laboratory of Toxicology and Biochemistry, School of Medicine, Reus, Spain.
J L
JL
Domingo
M
M
Gómez
M A
MA
Bosque
J
J
Corbella
D000536:Aluminum Hydroxide / Q000633:toxicity*; D000818:Animals; D005260:Female; D005327:Fetal Resorption; D005333:Fetus / Q000187:drug effects; D008098:Litter Size / Q000187:drug effects; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D012016:Reference Values; D012744:Sex Ratio; D013723:Teratogens
D013723:Teratogens; D000536:Aluminum Hydroxide