[Dynamics of inherent interactions between the classical and alternative pathways of complement activation in premature infants with suppurative-inflammatory diseases].
Altogether 57 premature infants were examined. Of these, 15 presented with neonatal sepsis, 36 with local purulent infection (LPI) of different etiology, and 6 children were conventionally normal serving as control. Early activation of the alternative pathway of the complement system was shown by the patients as compared with control. The development of neonatal sepsis was attended by the increased role played by the classical pathway of complement activation. At the same time the course of LPI was characterized by differences in the degree of participation of the classical and alternative pathways in the antiinfectious defence of the neonates. It has been established that high activation of the alternative pathway seen in the premature children may be considered as a prognostic sign enabling one to classify them with the risk group in terms of the possibility of the development in them of an infectious process.
Leonova
E S
ES
Belova
O N
ON
Vinogradova
T V
TV
Lialikova
G V
GV
Stefani
D V
DV
D000208:Acute Disease; D003167:Complement Activation; D003170:Complement Pathway, Alternative; D003171:Complement Pathway, Classical; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000276:immunology*; D007239:Infections / Q000276:immunology*; D011379:Prognosis; D013492:Suppuration / Q000276:immunology
Dinamika vnutrennego vzaimodeĭstviia mezhdu klassicheskim i al'ternativnym putiami aktivatsii sistemy komplementa u nedonoshennykh novorozhdennykh pri gnoĭno-vospalitel'nykh zabolevaniiakh.