Flucloxacillin compared with cefazolin in short-term prophylaxis for clean orthopedic surgery.
Two-hundred and fifty-two patients were included in a prospective, randomized, double-blind trial comparing the efficacy of flucloxacillin with that of cefazolin for clean orthopedic surgery. The preventive antibiotic regimen consisted of three 1-g injections perioperatively. There were 126 patients in each group, and the follow-up period was at least 6 months. Two deep (1.6%) and five superficial (4.0%) infections occurred in the flucloxacillin group. Three deep (2.4%) and five superficial (4.0%) infections developed in the cefazolin group.
Department of Orthopedic Surgery and Physical Medicine, Ghent University Hospital, Belgium.
J
J
Van Meirhaeghe
R
R
Verdonk
G
G
Verschraegen
P
P
Myny
G
G
Paeme
H
H
Claessens
D000293:Adolescent; D000368:Aged; D002437:Cefazolin / Q000627:therapeutic use*; D003023:Cloxacillin / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D005260:Female; D005436:Floxacillin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009985:Orthopedics; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000517:prevention & control*
D005436:Floxacillin; D002437:Cefazolin; D003023:Cloxacillin