[Correlation between thyroid hypofunction and the presence of circulating antithyroid microsomal antibodies. A phenomenon in the aged, prevalent in women].
The authors evaluated the existence of serum thyroid microsomal antibodies (anti-TMS) and their correlation, if any, with thyroid function in a group of 120 consecutive patients, who seemed clinically worthy to be studied from that point of view, even if they were lacking of a previous laboratory framing. Present study shows a consistent prevalence (81.8%) of anti-TMS concentrations were not related with any hormone parameter of thyroid function. Instead, the prevalence of anti-TMS positive subjects get to 69% in the 39 over-65 aged patients (32 women) of survey, with a concordance between high anti-TMS concentration and hypothyroidism of 87.5% in the subgroup. In these elderly patients circulating anti-TMS and serum TSH were found directly correlated (p less than 0.001), whereas serum FT4 was found in inverse correlation with the same antibodies (p less than 0.01). The consistent share of hypothyroid-aging patients, although mild or subclinical but clearly related with immunological phenomena, cannot be overlooked.
Custro
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Scafidi
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Costanza
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Indovina
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I
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000276:immunology*; D008297:Male; D008861:Microsomes / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology*
D001323:Autoantibodies
Correlazione tra ipofunzione tiroidea e presenza in circolo di anticorpi antitiroidei microsomiali. Fenomeno della terza età, prevalente nel sesso femminile.