[Effects of tetrodotoxin and verapamil on abnormal ventricular activity at the late stage of experimental myocardial infarction in dogs].
An in situ experimental study of the heart has demonstrated that verapamil++ (0.3 mg/kg), administered intravenously to dogs with complete transverse heart block one day after two-step occlusion of the left descending coronary artery either produced a 15-30% drop in the incidence of abnormal ventricular activity (AVA) in some experiments, or had no effect on the latter in others. Tetrodotoxin (3 micrograms/kg) produced a 20-44% drop in AVA in all experiments. Combined administration of 0.2 mg/kg verapamil++ and 2 micrograms/kg tetrodotoxin completely suppressed AVA. At an early phase of its development (5-10 hours after the occlusion of the left descending artery), AVA was completely suppressed both by 0.3 mg/kg verapamil and 3 micrograms/kg tetrodotoxin. Mechanisms of AVA and its progress following coronary-artery occlusion in dogs are discussed.
Aniukhovskiĭ
E P
EP
Ivanovich
T
T
Beloshapko
G G
GG
Rozenshtraukh
L V
LV
D000818:Animals; D004285:Dogs; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006327:Heart Block / Q000188:drug therapy* / Q000209:etiology; D006352:Heart Ventricles / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000150:complications*; D013779:Tetrodotoxin / Q000008:administration & dosage*; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage*
D013779:Tetrodotoxin; D014700:Verapamil
Deĭstvie tetrodotoksina i verapamila na abnorma'lnuiu aktivnos't zheludochkov v pozdneĭ stadii éksperimenta'lnogo infarkta miokarda.