Fatal aplastic anaemia and liver toxicity caused by D-penicillamine treatment of rheumatoid arthritis.
A 65 year old woman with rheumatoid arthritis developed marrow aplasia and jaundice owing to D-penicillamine treatment. Recovery of bone marrow was ineffective, and the patient finally died despite intensive therapeutic measures. The rare coexistence of myelotoxicity and hepatotoxicity is presented and discussed.
Department of Rheumatology, Ichilov Hospital, Tel Aviv Medical Center, Israel.
B
B
Fishel
M
M
Tishler
D
D
Caspi
M
M
Yaron
D000368:Aged; D000741:Anemia, Aplastic / Q000139:chemically induced*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007565:Jaundice / Q000139:chemically induced*; D008099:Liver / Q000187:drug effects; D010396:Penicillamine / Q000009:adverse effects*
D010396:Penicillamine