Prostaglandin F2 alpha effects on intraocular pressure negatively correlate with FP-receptor stimulation.
According to the current working classification for prostanoid receptors, the prostaglandin F2 alpha-sensitive receptor (FP-receptor) may be identified by comparing the rank order of activity of prostaglandin F2 alpha (PGF2 alpha) and its analogues. In order to further understand the pharmacology of PGF2 alpha-induced ocular hypotension, the intraocular pressure response to PGF2 alpha and selected analogues was compared with their rank order of activity in typical FP-receptor preparations such as contraction of the cat iris sphincter and affinity for corporal luteal membrane binding sites. The rank order of potency for decreasing intraocular pressure was as follows: PGF2 alpha greater than PGF1 alpha greater than 16-phenoxytetranor PGF2 alpha greater than 17-phenyltrinor PGF2 alpha = fluprostenol (inactive). For cat iris sphincter contraction, the rank order of potency appears to be fluprostenol = 17-phenyltrinor PGF2 alpha greater than 16-phenoxytetranor PGF2 alpha = PGF2 alpha greater than PGF1 alpha. The rank order of potency for PGF2 alpha analogues in decreasing intraocular pressure appears to negatively correlate with the rank order for cat iris sphincter contraction and literature values for corporal luteal membrane binding. It is concluded that the ocular hypotensive effect of PGF2 alpha is not mediated by the FP-receptor.
Allergan, Inc., Discovery Research, Irvine, California 92715.
D F
DF
Woodward
J A
JA
Burke
L S
LS
Williams
B P
BP
Palmer
L A
LA
Wheeler
E
E
Woldemussie
G
G
Ruiz
J
J
Chen
D000287:Administration, Topical; D000818:Animals; D002415:Cats; D015237:Dinoprost / Q000031:analogs & derivatives / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007429:Intraocular Pressure / Q000187:drug effects*; D007498:Iris / Q000187:drug effects; D008297:Male; D011680:Pupil / Q000187:drug effects; D011817:Rabbits; D011982:Receptors, Prostaglandin / Q000378:metabolism*; D013997:Time Factors; D014065:Tonometry, Ocular
D011982:Receptors, Prostaglandin; D015237:Dinoprost