Amides of beta-(4-chlorophenoxy)-alpha-phenyl-ethylamines are inhibitors of cholesterol biosynthesis in vitro.
Amides of beta-(4-chlorophenoxy)-alpha-phenyl-ethylamines were prepared and tested for their inhibitory activity on cholesterol biosynthesis in vitro. Among the substances prepared, (II e), (II g), (II k) and (II m) had much greater inhibitory activity than clofibrate.
Istituto di Chimica Farmaceutica, Universita di Milano, Italy.
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Diamantini
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Pescador
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002784:Cholesterol / Q000096:biosynthesis; D002994:Clofibrate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005227:Fatty Acids / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010627:Phenethylamines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000577:Amides; D000924:Anticholesteremic Agents; D005227:Fatty Acids; D010627:Phenethylamines; D002784:Cholesterol; D002994:Clofibrate