Nifedipine decreases the mitotic activity of adrenocortical cells in early stage of adrenal regeneration.
The influence of nifedipine, a calcium channel antagonist, on adrenal regeneration was investigated by evaluation of mitotic activity of adrenocortical cells. It was found, that nifedipine given at a daily dose of 10 mg/kg, reduced the proliferation of regenerating adrenal cortex on the fourth day after adrenal enucleation, but the inhibitory effect of nifedipine became insignificant on the eighth day after the operation.
Institute of Endocrinology, Academy of Medicine, Lódź, Poland.
J
J
Zieleniewski
B
B
Nowakowska-Jankiewicz
W
W
Zieleniewski
D000302:Adrenal Cortex / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D000311:Adrenal Glands / Q000502:physiology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration / Q000187:drug effects*
D002121:Calcium Channel Blockers; D009543:Nifedipine