Synthesis and in vitro antibacterial activity of some 1-(difluoromethoxyphenyl)quinolone-3-carboxylic acids.
We report on the synthesis of N-1-phenylquinolones in which the difluoromethoxy moiety is utilized as a halogen replacement. The antibacterial activity is discussed with reference to N-1-halophenylquinolones.
Medical Research Division, American Cyanamid Company, Lederle Laboratories, Pearl River, NY 10965.
W
W
Xiao
R
R
Krishnan
Y I
YI
Lin
E F
EF
Delos Santos
N A
NA
Kuck
R E
RE
Babine
S A
SA
Lang
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests
D042462:4-Quinolones; D000890:Anti-Infective Agents