[Patterns in the degradation of individual genes of thymocytes in irradiated rats].
Degradation of genes of actin, albumin, histones, heat shock protein, and ribosomal RNA within DNA of irradiated animal thymocytes has been investigated. It has been shown that single strand enzymatic breaks occurred in thymocyte DNA 2 h following irradiation are localized in linker sites of nucleosomes. All the transcribed genes under study degrade to fragments that correspond by their length to DNA of nucleosomes and their oligomers. The albumin gene nontranscribed in thymocytes also degrades; however, no low molecular weight fragments are found. The degree of gene degradation is invariable in time.
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D000818:Animals; D004249:DNA Damage; D004277:DNA, Single-Stranded / Q000032:analysis / Q000528:radiation effects; D005720:Gamma Rays; D005796:Genes / Q000528:radiation effects*; D008297:Male; D009691:Nucleic Acid Denaturation / Q000528:radiation effects; D009693:Nucleic Acid Hybridization / Q000528:radiation effects; D009707:Nucleosomes / Q000032:analysis / Q000528:radiation effects; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000528:radiation effects*; D013997:Time Factors
D004277:DNA, Single-Stranded; D009707:Nucleosomes
Zakonomernosti degradatsii individual'nykh genov v timotsitakh obluchennykh krys.