How does sepsis promote thrombosis in microvascular anastomoses?
This study on 100 rats, divided into five equal groups, has shown that chronic distant sepsis promotes occlusion of microvascular anastomoses to a significantly greater extent than aseptic inflammation, transient bacteraemia and even local infection. This may be related to the significant increase in the number of platelets in the group with distant sepsis.
McLean
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Department of Plastic, Reconstructive and Burns Surgery, Queens Mary's Hospital, Roehampton, London.
Ellis
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H
D000038:Abscess / Q000139:chemically induced / Q000150:complications; D000714:Anastomosis, Surgical; D000818:Animals; D005260:Female; D005263:Femoral Artery / Q000601:surgery*; D006083:Graft Occlusion, Vascular / Q000209:etiology; D008866:Microsurgery; D011552:Pseudomonas Infections / Q000150:complications*; D051381:Rats; D011919:Rats, Inbred Strains; D018805:Sepsis / Q000150:complications; D013530:Surgical Wound Infection / Q000150:complications; D013927:Thrombosis / Q000209:etiology*; D014425:Turpentine / Q000009:adverse effects
D014425:Turpentine