[Cytogenetic results in 9 cases of non-Hodgkin's lymphoma with a high grade of malignancy].
Cytogenetic studies were performed in nine patients with non-Hodgkin's lymphoma; four were lymphoblastic lymphoma, three Burkitt's-type and two diffuse lymphomas with mixed small and large cell. All cases showed pseudodiploid or hyperdiploid mode and, moreover, four cases had metaphases with a normal karyotype. All patients showed clonal chromosomal abnormalities, except one (lymphoblastic T-lymphoma). The translocations t (8;14) (q24;q32) and t (8;22) (q24;q11) were the abnormalities found in Burkitt's lymphoma. The translocation t (14;18) (q32;q21) was found in one case, of lymphoblastic type. In the other tumours, the chromosomes involved in the different aberrations were: #1, #3, #7, #8, #9, #14 and #17. We attempted to correlate the cytogenetic findings with histology and prognosis.
C
C
López Ginés
R
R
Gil
M
M
Gregori-Romero
A
A
Pellín
A
A
Llombart-Bosch
D000328:Adult; D000368:Aged; D000782:Aneuploidy; D002051:Burkitt Lymphoma / Q000235:genetics / Q000473:pathology; D002675:Child, Preschool; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014178:Translocation, Genetic
Resultados citogenéticos en nueve casos de linfomas no-Hodgkin de alto grado de malignidad.