Pharmacokinetics and tissue penetration of cefepime.
The pharmacokinetics of cefepime were studied following a 2 g intravenous infusion, by measuring concentrations in plasma, inflammatory fluid and urine. Mean peak plasma concentrations of 193.1 mg/l were achieved at the end of the 30 min infusion. The mean plasma elimination half-life was 2.1 h. Penetration into inflammatory fluid was rapid, with mean peak levels of 91.5 mg/l occurring 0.9 h after the end of the infusion. Urinary elimination accounted for 98.9% of the dose within 8 h. Therapeutic plasma levels (greater than 2 mg/l) were present for at least 8 h after the end of the infusion, suggesting that twice or three times daily dosing should be sufficient to treat infections due to susceptible organisms.
Department of Medical Microbiology, Dudley Road Hospital, Birmingham, UK.
K J
KJ
Nye
Y G
YG
Shi
J M
JM
Andrews
R
R
Wise
D000328:Adult; D001768:Blister / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism; D000077723:Cefepime; D002511:Cephalosporins / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male
D002511:Cephalosporins; D000077723:Cefepime