[Moderate deficiency of Factor XII associated with postoperative deep venous thrombosis].
The interrelationship between factor XII deficiency (Hageman trait) and thrombosis is well known. A case of moderate factor XII deficiency (activity, 30%) associated to deep vein thrombosis, which occurred in the popliteal region of the left lower limb after abdominal surgery, is reported. The deficit was found in 4 family members of the three generations studied, and all of them showed a close interrelationship between factor XII activity and kallikrein levels. Prolonged APTT was found in 3 of the 4 affected subjects. A multiallelic model is suggested to explain the genetic transmission of this impairment.
R
R
Cornudella
F
F
Puente
J L
JL
Hortells
M
M
Gutiérrez
D000368:Aged; D005175:Factor XII Deficiency / Q000150:complications* / Q000235:genetics; D005260:Female; D006801:Humans; D007610:Kallikreins / Q000172:deficiency; D008297:Male; D010314:Partial Thromboplastin Time; D010375:Pedigree; D011183:Postoperative Complications / Q000209:etiology*; D013924:Thrombophlebitis / Q000209:etiology*
D007610:Kallikreins
Déficit moderado de factor XII asociado a trombosis venosa profunda postoperatoria.