Functional activity patterns in the forebrain of swimming rats: a 5 min 2-deoxyglucose study.
Effects of 5 min of swimming on functional activity patterns in the rat forebrain were examined by high resolution autoradiographic assessment of [14C]2-deoxyglucose ([14C]2-DG) uptake. In autoradiograms made from swimming rats, the isocortex displayed a columnar pattern in which columns of high optical density, oriented perpendicularly to the cortical surface, were separated by columns of low optical density of similar orientation. Increased [14C]2-DG uptake in swimming rats compared to resting rats was also apparent in the lateral septal nucleus, globus pallidus, and endopiriform nucleus. The results demonstrate that 2-DG can be used in short survival uptake experiments to gain insight into neuroanatomical patterns of functional activity.
Duncan
G E
GE
Department of Cell Biology and Anatomy, School of Medicine, University of North Carolina, Chapel Hill 27599.
Stumpf
W E
WE
Breese
G R
GR
Mitra
K E
KE
D000818:Animals; D001345:Autoradiography; D003837:Deoxy Sugars / Q000493:pharmacokinetics*; D003847:Deoxyglucose / Q000493:pharmacokinetics*; D004734:Energy Metabolism; D005625:Frontal Lobe / Q000378:metabolism* / Q000502:physiology; D008297:Male; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming
D003837:Deoxy Sugars; D003847:Deoxyglucose