The renal carcinogenic effect of Merpafol in the Fischer 344 rat.
Three groups of Fischer 344 rats were fed Merpafol (Makhteshim, Israel), an agricultural fungicide, in increasing concentrations for a period of 2 years. A control group was maintained under identical conditions, but without the addition of the fungicide in the diet. A range of nonneoplastic and neoplastic lesions were observed in the kidneys of rats fed Merpafol. The histogenesis of the renal tumors is discussed in relation to chemical-induced epithelial hyperplasia and cystic tubular dilation. Comparative aspects of renal cyst development and carcinoma in humans are also discussed.
Nyska
A
A
Department of Pathology, Life Science Research Israel Ltd., Ness Ziona.
Waner
T
T
Pirak
M
M
Gordon
E
E
Bracha
P
P
Klein
B
B
D000236:Adenoma / Q000139:chemically induced / Q000473:pathology / Q000556:secondary; D000818:Animals; D002215:Captan / Q000031:analogs & derivatives* / Q000633:toxicity; D002273:Carcinogens; D002277:Carcinoma / Q000139:chemically induced / Q000473:pathology / Q000556:secondary; D053138:Cyclohexenes; D004305:Dose-Response Relationship, Drug; D005260:Female; D005659:Fungicides, Industrial / Q000633:toxicity*; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D002273:Carcinogens; D053138:Cyclohexenes; D005659:Fungicides, Industrial; C001614:captafol; D002215:Captan