Increased resistance to transforming growth factor beta accompanies neoplastic progression of rat tracheal epithelial cells.
Transforming growth factor beta (TGF beta) is an inhibitor of normal epithelial cell growth. To investigate the role of TGF beta in respiratory epithelial cell neoplasia, normal, preneoplastic, tumorigenic and tumor-derived rat tracheal epithelial (RTE) cells were plated in serum-free medium and grown in the presence of 0-300 pg TGF beta 1/ml. TGF beta 1 markedly inhibited the formation of colonies by primary RTE cells and some preneoplastic RTE cells. However, tumor-derived RTE cells were relatively resistant to TGF beta 1-induced growth inhibition. Resistance to TGF beta 1-induced growth inhibition, therefore, accompanies neoplastic progression of RTE cells.
Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM 87185.
A F
AF
Hubbs
F F
FF
Hahn
D G
DG
Thomassen
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D004351:Drug Resistance; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D051379:Mice; D008819:Mice, Nude; D011230:Precancerous Conditions / Q000473:pathology*; D051381:Rats; D011916:Rats, Inbred F344; D014132:Trachea / Q000166:cytology / Q000187:drug effects; D015291:Transforming Growth Factors / Q000494:pharmacology*
D008769:Methylnitronitrosoguanidine; D015291:Transforming Growth Factors