Selective inhibition of complex I of the brain electron transport system by tetrahydroisoquinoline.
The effects of 1,2,3,4-tetrahydroisoquinoline on the enzyme-protein complexes in the electron transport system were studied in mitochondria isolated from mouse brains. Tetrahydroisoquinoline significantly inhibited the activity of NADH-ubiquinone reductase, but had no effect on the activities of succinate-ubiquinone reductase, dihydroubiquinone-cytochrome c reductase, or ferrocytochrome c-oxygen reductase. The biochemical properties of tetrahydroisoquinoline in this study were quite similar to those of the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium ion.
Department of Neurology, Jichi Medical School, Tochigi Japan.
K
K
Suzuki
Y
Y
Mizuno
M
M
Yoshida
D000818:Animals; D001921:Brain / Q000502:physiology*; D004579:Electron Transport / Q000187:drug effects*; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology*; D051379:Mice; D013367:Submitochondrial Particles / Q000502:physiology*; D044005:Tetrahydroisoquinolines
D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C014843:1,2,3,4-tetrahydroisoquinoline