C7 polymorphism in Japanese: new allele C7*8.
The polymorphism of C7 was investigated in neuraminidase-treated sera from 513 unrelated Japanese individuals using isoelectric focusing followed by an electroimmunoblotting technique. Besides the common phenotypes 5 rare variants including 2 types of new variants were detected. The family analysis suggested the hereditary occurrence of a new allele C7*8. The allele frequencies were: C7*1 = 0.8314, C7*2 = 0.0926, C7*3 = 0.0380, C7*4 = 0.0331, C7*6 = 0.0010, and C7*8 = 0.0039.
Department of Legal Medicine, Yamanashi Medical University, Japan.
N
N
Komatsu
A
A
Kido
M
M
Oya
D000483:Alleles; D003184:Complement C7 / Q000235:genetics*; D003627:Data Interpretation, Statistical; D006801:Humans; D015151:Immunoblotting; D007525:Isoelectric Focusing; D007564:Japan; D010375:Pedigree; D011110:Polymorphism, Genetic
D003184:Complement C7