Prevalence of intranuclear particles in liver pathologies.
An ultrastructural study of the prevalence of electron dense 23-27 nm intranuclear particles was carried out on liver biopsies from patients with NANB chronic active hepatitis (CAH), Delta + CAH, HBsAg + CAH, nonviral liver pathologies and in one healthy volunteer. The particles were classified according to aggregation pattern and were found to be correlated with NANB CAH and Delta + CAH. No particles were observed in nonviral liver pathologies. A close antigenic relationship has been shown between the cytoplasmic alterations observed in NANB and delta hepatitis in chimpanzees. Our data indicate that there is a structural similarity between the intranuclear particles seen in both Delta and NANB hepatitis, thus reinforcing the hypothesis that the NANB and Delta agents are closely related.
Borgia
G
G
Cicciarello
S
S
Crowell
J
J
Lambiase
A
A
Ciampi
R
R
Reynaud
L
L
Abrescia
N
N
Piazza
M
M
D000328:Adult; D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure*; D005260:Female; D006518:Hepatitis Viruses / Q000648:ultrastructure; D006525:Hepatitis, Viral, Human / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure*; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged