Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage.
Reperfusion of isolated rabbit heart after 60 min of ischaemia resulted in poor recovery of mechanical function, release of reduced (GSH) and oxidized glutathione (GSSG), reduction of tissue GSH/GSSG ratio and shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. Pretreatment of the isolated heart with propionyl-L-carnitine (10(-7) M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG. This effect was specific for propionyl-L-carnitine as L-carnitine and propionic acid did not modify myocardial damage.
Ferrari
R
R
Cattedra di Cardiologia dell'Università di Brescia, Italy.
Ceconi
C
C
Curello
S
S
Pasini
E
E
Visioli
O
O
D000818:Animals; D002331:Carnitine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003327:Coronary Disease / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000032:analysis; D005980:Glutathione Reductase / Q000032:analysis; D066298:In Vitro Techniques; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D010084:Oxidation-Reduction; D011312:Pressure; D011422:Propionates / Q000494:pharmacology; D011817:Rabbits
D011422:Propionates; C003223:propionylcarnitine; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione; C029658:propionic acid; D002331:Carnitine