[The role of alkaline secretion of the duodenal mucosa in protecting the mucosa from hydrochloric acid].
In animal experiments, an in vivo comparison was made of the alkaline secretion (AS) of the duodenal mucosa and of its ability to defend against hydrochloric acid. An i.v. infusion of NaHCO3 and glucagon was applied to stimulate AS, and one of NH4Cl, vasopressin and furosemide to depress it. In the stage of AS influenced via various mechanisms and to different extents, the luminal surface of the duodenum was exposed with HCl. The extent of mucosal damage was determined by quantitative morphometry. The mucosa-damaging effect of standardized HCl-exposure was significantly lower in the stage of enhanced AS than in the control experiments. In contrast, during inhibition of AS hydrochloric acid caused more extensive and deeper mucosal damage. A linear correlation was observed between the degree of AS of the duodenum and the proportion of damaged intestinal villi. In the opinion of the authors, inhibition of the As of the duodenum is accompanied by a decreased acid tolerance of the mucosa, while its stimulation enhances the ability of the mucosa to defend against hydrochloric acid.
P
P
Vattay
W
W
Etienne
F
F
Wolfgang
M
M
Starlinger
R
R
Schiessel
D000468:Alkalies / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D004386:Duodenum; D005260:Female; D005744:Gastric Acid / Q000502:physiology*; D007413:Intestinal Mucosa / Q000378:metabolism*; D011817:Rabbits
D000468:Alkalies
A duodenumnyálkahártya alkáliszekréciójának jelentösége a sósavval szembeni védekezésben.