Araguspongines B, C, D, E, F, G, H, and J, new vasodilative bis-1-oxaquinolizidine alkaloids from an okinawan marine sponge, Xestospongia sp.
Nine new vasodilative alkaloids, araguspongines A, B (1), C (2), D (3), E (4), F (5), G (6), H (7), and J (8), were isolated from an Okinawan marine sponge, Xestospongia sp. On the basis of chemical and physicochemical evidence, the absolute stereostructures of araguspongines B, D, E, F, G, H, and J were determined respectively as 1, 3, 4, 5, 6, 7, 8, and the relative stereostructure of araguspongine C was determined as 2 having two 1-oxaquinolizidine moieties. Araguspongines B, D, and E each comprised a pair of the enantiomers, 1a and 1b, 3a and 3b, and 4a and 4b, respectively.
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Kobayashi
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Kawazoe
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I
Kitagawa
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000378:metabolism*; D014665:Vasodilator Agents / Q000302:isolation & purification*
D000470:Alkaloids; D014665:Vasodilator Agents