Addisonian crisis induced by treatment with rifampicin.
A patient with spinal tuberculosis and subclinical adrenal tuberculosis who developed acute Addisonian crisis on starting anti-tuberculosis therapy including rifampicin is reported. The possibility that many patients with tuberculosis have adrenal involvement with limited hormonal reserve and that they may develop incipient adrenal failure on commencing treatment is discussed.
Department of Infectious Diseases, Northwick Park Hospital, Harrow, Middlesex.
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Wilkins
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Hnizdo
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Cope
D000224:Addison Disease / Q000139:chemically induced*; D000307:Adrenal Gland Diseases / Q000150:complications*; D000995:Antitubercular Agents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000009:adverse effects*; D014383:Tuberculosis, Endocrine / Q000150:complications*; D014399:Tuberculosis, Spinal / Q000150:complications*
D000995:Antitubercular Agents; D012293:Rifampin