Opioid modulation of feeding and drinking in fowls.
1. D-ala2-methionine enkephalinamide (DME), the stable analogue of met-enkephalin (an opioid agonist), stimulated food intake of immature hens in the first 30 min after intracerebroventricular injection (2 and 8 micrograms/kg), but had no effect on either food or water intake when injected intravenously (15 and 60 micrograms/kg). 2. Naloxone (an opioid antagonist) had no effect on food intake after either intracerebroventricular (50 and 200 micrograms/kg) or intravenous (1 and 4 mg/kg) injection, but inhibited water intake in the second 30 min after intravenous injection. 3. Water intake was not measured after the intracerebroventricular injections of DME and naloxone. 4. Both feeding and drinking were inhibited in a dose-related way in the 7 h after intramuscular injection of nalmefene (0.2, 0.4, 0.8 and 1.6 mg/kg), a more potent and longer-lasting antagonist than naloxone. 5. These data are compared with published results from similar work with birds and mammals. It is concluded that central release of endogenous opioids may reinforce both feeding and drinking in fowls, but whereas opioid blockage affects feeding more than drinking in pigeons and quail, the opposite appears to be the case in fowls.
Savory
C J
CJ
AFRC Institute for Physiology and Genetics Research, Midlothian Scotland.
Gentle
M J
MJ
Yeomans
M R
MR
D000818:Animals; D002645:Chickens / Q000502:physiology*; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D007273:Injections, Intramuscular; D007275:Injections, Intravenous / Q000662:veterinary; D007276:Injections, Intraventricular; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D009271:Naltrexone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors
D009270:Naloxone; D004744:Enkephalin, Methionine; D009271:Naltrexone; C022118:enkephalinamide-Met, Ala(2)-; C038981:nalmefene