Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV.
Polyclonal B cell activation is commonly observed in AIDS and in infection with HIV. The effect of HIV on the induction of B cell stimulatory factor 2 (BSF-2) production was examined, since BSF-2 plays an essential role in the differentiation of activated B cells to Ig-secreting cells. Increased BSF-2 mRNA levels and increased BSF-2 secretion were observed soon after exposure of mononuclear cells isolated from healthy donors to both "live" and inactivated HIV. HIV-induced BSF-2 production was seen in monocyte/macrophages, but not in T cells. These results suggest that the HIV-induced overproduction of BSF-2 might contribute to the polyclonal B cell activation seen in AIDS and in infection with HIV.
Institute for Molecular and Cellular Biology, Osaka University, Japan.
K
K
Nakajima
O
O
Martínez-Maza
T
T
Hirano
E C
EC
Breen
P G
PG
Nishanian
J F
JF
Salazar-Gonzalez
J L
JL
Fahey
T
T
Kishimoto
D001402:B-Lymphocytes / Q000276:immunology*; D001667:Binding, Competitive; D002460:Cell Line; D005786:Gene Expression Regulation; D006678:HIV / Q000276:immunology / Q000502:physiology*; D015483:HIV Antibodies / Q000502:physiology; D006801:Humans; D015850:Interleukin-6; D007378:Interleukins / Q000096:biosynthesis* / Q000235:genetics; D008213:Lymphocyte Activation; D008264:Macrophages / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism; D009500:Neutralization Tests
D015483:HIV Antibodies; D015850:Interleukin-6; D007378:Interleukins