[The effect of cigarette smoking on the cicatrization of duodenal ulcers in patients treated with cimetidine. The role of acid hypersecretion].
In 92 patients with duodenal ulcer, male cigarette smokers treated with cimetidine 1 g/day, 66.3% healed after four weeks. No differences were observed between healed and non-healed patients for age, symptom period before treatment, early onset (less than 30 years), multiple ulcers. In non-healed patients, more had a greater ulcer diameter (p = 0.0026) and more were heavy smokers (p = 0.0002). In non-healed patients, pentagastrin-induced maximal acid output, corrected for age, was higher than in healed patients (p less than 0.05). We confirmed the linear relationship between acid output and the number of cigarettes smoked per day (p less than 0.05). These observations suggest that cigarette smoking over a long period could stimulate the vagus. This would increase the functional parietal cell mass and explain the observed increase in pentagastrin-induced acid output.
G
G
Ligny
J
J
Van Ccauter
J P
JP
Henry
D000328:Adult; D002927:Cimetidine / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000503:physiopathology*; D005744:Gastric Acid / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin / Q000494:pharmacology; D012907:Smoking / Q000503:physiopathology*; D014945:Wound Healing
D002927:Cimetidine; D010418:Pentagastrin
Influence de la consommation de cigarettes sur la cicatrisation de l'ulcère duodénal chez des malades traités par la cimétidine. Rôle de l'hypersécretion acide.