[Allergological study of breast feeding, ovalbumin and specific IgG, IgM and IgA antibodies to ovalbumin in human milk].
Ovalbumin (OA) and specific antibodies to OA were evaluated by ELISA in 92 colostrum, 366 mature milk and 12 cord blood samples. Anti-OA IgG antibody titers in colostrum were lower than those in cord blood and were not detectable in several samples. Anti-OA IgM antibody titers in colostrum were comparatively high and decreased on the days following postpartum. Anti-OA IgA antibody titers were the highest in the colostrum and decreased on the following days, but remained constant in mature milk. On the other hand, OA was detected in 27.2% of colostrum and 17.2% of mature milk samples, in concentrations from 0.5-59.0 ng/ml. In mature milk, the positive rates of OA were significantly elevated by egg ingestion by the mothers. OA in mature milk from allergic mothers tended to be more readily detectable than that from non-allergic mothers. These results suggest that avoidance of the specific food antigens by mothers is important for therapy and prevention on allergic disease in their breast-fed infants.
H
H
Ogura
Y
Y
Ogura
T
T
Tomoda
N
N
Zushi
T
T
Kurashige
D001942:Breast Feeding; D004531:Eggs / Q000009:adverse effects; D004797:Enzyme-Linked Immunosorbent Assay; D005512:Food Hypersensitivity / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008895:Milk, Human / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010047:Ovalbumin