Development of the neuronal system containing neuropeptide Y in the rat hypothalamus.
In the rat hypothalamus, neuropeptide Y-containing neurons first appeared on day 14.5 of gestation in the arcuate nucleus and in the dorsolateral hypothalamic area. Until birth neuropeptide Y-containing cell bodies increased in number in the arcuate, dorsomedial-lateral and paraventricular nuclei, but disappeared thereafter, but some cells remaining in the arcuate nucleus. In animals treated neonatally with monosodium L-glutamate to destroy the arcuate nucleus, neuropeptide Y-immunoreactivity became evident in many cells scattered in the magnocellular paraventricular and dorsomedial-lateral hypothalamic nuclei on day 16 but not on days 60 and 12. These neuropeptide Y-immunoreactive neurons which appeared in the paraventricular nucleus were also vasopressin-positive. Neuropeptide Y fibers, on the contrary, remarkably diminished in number on day 16, particularly in the paraventricular and dorsomedial-lateral nuclei, and the medial preoptic area, but made a considerable recovery on days 60 and 120. Hence it is probable that, in normal ontogenetic progress, the development of the neuropeptide Y fibers in these areas is inhibitorily affected by that of arcuate neuropeptide Y neurons.
Kagotani
Y
Y
Department of Anatomy, School of Medicine, University of Tokushima, Japan.
Hashimoto
T
T
Tsuruo
Y
Y
Kawano
H
H
Daikoku
S
S
Chihara
K
K
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D005314:Embryonic and Fetal Development; D005865:Gestational Age; D005971:Glutamates / Q000494:pharmacology*; D007031:Hypothalamus / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism* / Q000502:physiology; D010286:Paraventricular Hypothalamic Nucleus / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012970:Sodium Glutamate / Q000494:pharmacology*
D005971:Glutamates; D009478:Neuropeptide Y; D012970:Sodium Glutamate