In vitro sodium salicylate release from a sucrose polyester matrix.
Sucrogel H-70, a recently synthesized polyester of sucrose, was investigated as a potential drug delivery matrix. In this study, the release of sodium salicylate was examined from a reservoir-controlled release device. It is shown that sodium salicylate release follows zero-order kinetics in the three media studied (i.e., water and simulated gastric and intestinal fluids).
Castellano
P M
PM
Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Pastoriza
M A
MA
Martińez de Bertorello
M
M
Bertorello
H E
HE
Horas
J A
JA
D001826:Body Fluids / Q000032:analysis; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D005750:Gastric Juice / Q000032:analysis; D005782:Gels; D007422:Intestines / Q000032:analysis; D011108:Polymers; D012459:Salicylates / Q000008:administration & dosage / Q000032:analysis*; D020156:Salicylic Acid; D013395:Sucrose
D003692:Delayed-Action Preparations; D005782:Gels; D011108:Polymers; D012459:Salicylates; D013395:Sucrose; D020156:Salicylic Acid