MHC related genetic susceptibility to Hodgkin's disease.
The present report describes 4 Caucasoid families, HLA genotyped, with at least 2 affected siblings suffering from Hodgkin's disease. The affected sibling pairs were identical (2 shared haplotypes) in 2 families and haploidentical (1 shared haplotype) in the 2 others. These results together with the data already published provide evidence for a distortion of the segregation of HLA haplotypes: from a total of 43 pairs of siblings reported, the observed repartition is 22, 15, 6 (2, 1, 0 shared haplotypes respectively) instead of 10.75, 21.5, 10.75 (mendelian repartition). The excess of identical siblings pairs (51% instead of 25%) (p less than 10(-5) confirms the existence of a genetic linkage between the chromosomal HLA region and the susceptibility to the disease.
Kalidi
I
I
INSERM U93, Hôpital Saint-Louis, Paris, France.
Masset
M
M
Gony
J
J
Marcelli
A
A
Jeannet
M
M
Irlé
C
C
Bauters
F
F
Tchernia
G
G
Turpin
F
F
Gisselbrecht
C
C
D000293:Adolescent; D000328:Adult; D004198:Disease Susceptibility; D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006689:Hodgkin Disease / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex; D008297:Male; D010375:Pedigree
D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II