A good outcome pregnancy in a patient with paroxysmal nocturnal hemoglobinuria.
In this report, the maternal and fetal risks in a patient with paroxysmal nocturnal hemoglobinuria (PNH) were evaluated. A patient with PNH carried a pregnancy to successful delivery, with a healthy male infant, and suffered from postpartum cerebral subcortical, but not hepatic, thrombosis followed by recovery. An elevation of serum levels of lactate dehydrogenase isoenzyme, alpha-hydroxybutyrate dehydrogenase, was observed during pregnancy. The level was ameliorated to the non-pregnant level by delivery. However, hemoglobin concentrations during pregnancy and post-partum were at least 8 g/dl. This is a first report that shows tight coupling between an onset of intravenous hemolysis and pregnancy. The management of pregnancies in such patients is also discussed.
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
H
H
Takagi
A
A
Imai
I
I
Kawabata
H
H
Sumi
S
S
Shiraki
T
T
Tamaya
D000328:Adult; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000652:urine*; D011256:Pregnancy Outcome