Differential effect of clomipramine treatment on m-chlorophenylpiperazine-induced increases in plasma prolactin and corticosterone in rats.
Intravenous administration of m-chlorophenylpiperazine (m-CPP, a serotonin agonist) to rats increased plasma prolactin and corticosterone concentrations. Long-term (21-day) and short-term (3-day) treatment with the tricyclic antidepressant, clomipramine, did not have any significant effect on baseline levels of either prolactin or corticosterone. Long-term but not short-term clomipramine treatment significantly potentiated m-CPP's effect on plasma prolactin. On the other hand, both long-term and short-term clomipramine treatment significantly attenuated m-CPP's effect on plasma corticosterone. These findings are consistent with other animal and clinical studies demonstrating a differential effect of antidepressant treatment on two different serotonin-mediated neuroendocrine functions.
Laboratory of Clinical Science National Institute of Mental Health, Bethesda, MD 20892.
K M
KM
Wozniak
C S
CS
Aulakh
J L
JL
Hill
D L
DL
Murphy
D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D002997:Clomipramine / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood*; D006016:Glycolates / Q000494:pharmacology*; D008297:Male; D011388:Prolactin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D006016:Glycolates; C008340:mecoprop; D011388:Prolactin; D008456:2-Methyl-4-chlorophenoxyacetic Acid; D002997:Clomipramine; D003345:Corticosterone