No evidence for a circadian rhythm of protein synthesis in the rat suprachiasmatic nuclei.
The mammalian suprachiasmatic nuclei contain an endogenous circadian pacemaker. A quantitative autoradiographic tracer method that measures L-[1-14C]leucine incorporation into protein was used to determine whether the overall rate of protein synthesis in the nuclei varies in a circadian fashion. Unlike the robust circadian rhythms of electrical activity and energy metabolism previously recorded from the nuclei at the two time points sampled, protein synthesis remained constant.
Department of Neurology, University of Massachusetts Medical School, Worcester 01655.
T E
TE
Scammell
W J
WJ
Schwartz
C B
CB
Smith
D000596:Amino Acids / Q000097:blood; D000818:Animals; D002940:Circadian Rhythm; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013493:Suprachiasmatic Nucleus / Q000378:metabolism*
D000596:Amino Acids; D009419:Nerve Tissue Proteins