Resistance of some capsular serotype D strains of Pasteurella multocida to rabbit polymorphonuclear neutrophil phagocytosis.
The mechanism of resistance of Capsular Type D strains of Pasteurella multocida to killing by rabbit polymorphonuclear neutrophils (PMN) was studied using an in vitro assay that differentiates intra- from extracellular bacteria. Two Capsular Type D strains (3761 and 3766), resistant to killing by rabbit PMN, and one Type A strain (R1), susceptible to PMN destruction, were compared. After combining opsonized bacteria and PMN, the Capsular Type D Strains 3761 and 3766 remained extracellular while the Capsular Type A Strain R1 was internalized by PMN. Thus, both Type D strains were resistant to phagocytosis by rabbit PMN.
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Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor 48109.
D000818:Animals; D009504:Neutrophils / Q000276:immunology*; D010325:Pasteurella / Q000145:classification / Q000276:immunology*; D010587:Phagocytosis; D011817:Rabbits; D012703:Serotyping; D013045:Species Specificity