[Clinical significance of sialic acid in the CSF; in relation to the malignancy and leptomeningeal dissemination].
We examined the level of sialic acid in cerebrospinal fluid (CSF) in 20 patients with brain tumor, and 5 patients with non-neoplastic disease of central nervous system. CSF concentration of sialic acid in the patients with malignant and semi-malignant or benign brain tumor was 5.26 +/- 2.39 mg/dl, and 1.82 +/- 1.61 mg/dl, respectively. In patients with non-neoplastic disease, it was 1.64 +/- 1.53 mg/dl. The difference between groups was statistically significant (p less than 0.005). In two patients with malignant brain tumor, the level of sialic acid was decreased by radiation therapy or intrathecal chemotherapy. In conclusion, CSF concentration of sialic acid was significant of diagnosis of brain tumor character of malignancy, and effect of therapy for CSF dissemination.
Department of Neurosurgery, Kumamoto University Medical School, Japan.
K
K
Moroki
J
J
Kuratsu
S
S
Yoshioka
M
M
Kohchi
S
S
Uemura
Y
Y
Matsukado
Y
Y
Ushio
D001099:Arachnoid; D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008577:Meningeal Neoplasms / Q000556:secondary* / Q000628:therapy; D010841:Pia Mater; D011237:Predictive Value of Tests; D012794:Sialic Acids / Q000134:cerebrospinal fluid*
D014408:Biomarkers, Tumor; D012794:Sialic Acids