Low calcium-induced epileptiform activity in hippocampal slices from infant rats.
Ca2+-free solutions evoke spontaneous epileptiform activity in area CA1 of hippocampal slices from adult and young rats at the age of 7/8, 14/15 and 23/24 days. Studies with combined Ca2+-selective and K+-selective microelectrodes showed that this epileptiform activity commenced at higher Ca2+ levels in young than in adult animals. Unlike in disinhibition seizures, [K+]o did not rise to abnormally high levels. We further found that Ca2+ washout curves from young animals were much faster than those from adult slices, suggesting that the extracellular space is wider in young animals than in adult ones.
Albrecht
D
D
Institute of Neurophysiology, University of Cologne, Cologne, F.R.G.
Heinemann
U
U
D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000502:physiology*; D004827:Epilepsy / Q000503:physiopathology*; D006624:Hippocampus / Q000254:growth & development / Q000503:physiopathology*; D066298:In Vitro Techniques; D051381:Rats
D002118:Calcium