[Acute intestinal occlusion and calcium antagonists].
A 41 years old male patient suffering from angina pectoris was treated with diltiazem (Tildiem). He was administered with nifedipine (Adalate) 3 times in succession and each time either complete or partial intestinal occlusion occurred. A laparotomy was carried out after the first occlusion, but no organic lesions were found. The search for an alternate non-drug related explanation proved negative. The most likely hypothesis is that of a direct relaxant activity on intestinal smooth muscle, which would explain the functional nature of the occlusion. Therefore it must be considered that the two drugs acted synergistically.
Lamaison
D
D
Abrieu
V
V
Fialip
J
J
Dumas
R
R
Andronikoff
M
M
Lavarenne
J
J
D000328:Adult; D002121:Calcium Channel Blockers / Q000009:adverse effects; D004110:Diltiazem / Q000009:adverse effects*; D004357:Drug Synergism; D006801:Humans; D007415:Intestinal Obstruction / Q000139:chemically induced*; D008297:Male; D009543:Nifedipine / Q000009:adverse effects*
D002121:Calcium Channel Blockers; D004110:Diltiazem; D009543:Nifedipine
Occlusion intestinale aiguë et antagonistes calciques.