Impaired renal hemodynamic but conserved natriuretic response to dopamine in patients with renal disease.
Renal hemodynamics and sodium excretion were determined before and during infusion of dopamine in doses ranging from 0.25 to 8 micrograms/kg/min in healthy volunteers (n = 15) and in patients with renal disease and moderately impaired renal function (n = 21, baseline glomerular filtration rate 34-85 ml/min). While in normal volunteers dopamine resulted in marked renal vasodilation (maximal fall in filtration fraction 24%), in patients with moderately impaired renal function, the renal vasodilatory response to dopamine was impaired (maximal fall in FF 13%) and was found to depend on baseline glomerular filtration rate. Infusion of dopamine in doses of 2 micrograms/kg/min and higher resulted in an increase in urinary sodium excretion, which was comparable for healthy volunteers and patients with renal disease. We conclude that dopamine results in a predominantly efferent glomerular vasodilation and, therefore, may be salutary in lowering intraglomerular hypertension. However, in patients with renal disease the renal hemodynamic response to dopamine infusion is impaired compared to healthy volunteers, while the natriuretic response is maintained.
Department of Medicine, University Hospital Groningen, The Netherlands.
A J
AJ
Smit
S
S
Meijer
H
H
Wesseling
W D
WD
Reitsma
A J
AJ
Donker
D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007668:Kidney / Q000098:blood supply; D007674:Kidney Diseases / Q000503:physiopathology*; D007684:Kidney Tubules / Q000378:metabolism; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D010710:Phosphates / Q000378:metabolism; D012039:Regional Blood Flow / Q000187:drug effects
D010710:Phosphates; D002118:Calcium; D004298:Dopamine