Pivmecillinam in long-term prophylaxis to girls with recurrent urinary tract infection.
Pivmecillinam in a single bed-time dose of 5-10 mg/kg was given as long-term prophylaxis to 20 girls with recurrent bacteriuria for a total of 228 months. Symptomatic recurrences occurred in 4 girls, i.e. 1.8 infections/100 months as compared to 17/100 months during the year preceding the study. The frequency of positive urine cultures during prophylaxis was 11%. 10 of the 15 isolates were enterococci, resistant to mecillinam. In rectal swabs examined for the presence of aerobic gram-negative bacteria, enterobacteria were isolated in 78% with a low rate of resistance to mecillinam (11%). Thus pivmecillinam offered effective protection against recurrent urinary tract infections, and did not tend to select resistant enterobacteria in the bowel, but allowed resistant enterococci to cause a few symptomatic infections.
Department of Paediatrics, Gothenburg University, Göteborg, Sweden.
U
U
Jodal
P
P
Larsson
S
S
Hansson
C A
CA
Bauer
D000293:Adolescent; D000667:Ampicillin / Q000031:analogs & derivatives*; D001437:Bacteriuria / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D004755:Enterobacteriaceae / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D010917:Pivampicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D011549:Pseudomonas / Q000302:isolation & purification; D012008:Recurrence; D013291:Streptococcus / Q000302:isolation & purification; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control*
D010917:Pivampicillin; D000667:Ampicillin