The distribution of blood groups and HLA types in 59 cases of congenital dislocation of the hip.
One-hundred-and-eight patients with congenital dislocation of the hip (CDH) were ABO and Rh(D) typed. Fifty-nine of these patients were also HLA-A, -B, and -DR typed whenever technically possible and in addition the Rhesus, MNSs, Lutheran, Kell, Duffy, and Kidd groups were determined as part of a wider study into hereditary factors in CDH. No association was found between CDH and any of these red cell groups and HLA types. A slight trend towards a decrease of the HLA antigens B7 and DR2 was noted, and a slight increase of B27 and DR7. The increase in frequency of group B present in Italian children was not found in this British study, nor did we find an increase of HLA-A1 as previously reported in Greek children with CDH.
Smith
D S
DS
Wessex Regional Transfusion Centre, Southampton, U.K.
Wilkinson
J A
JA
D001789:Blood Group Antigens; D005260:Female; D015234:HLA-A Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006618:Hip Dislocation, Congenital / Q000097:blood*; D006801:Humans; D008297:Male
D001789:Blood Group Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens