["Induced detoxification treatment" of opiate dependent patients--a new therapy concept].
Induced detoxification treatment of opiate addicts by means of naloxone was developed at the intensive care unit of the Department of Psychiatry at the University of Vienna. Two methods were tested 1. Rapid opiate withdrawal by means of a staggered naloxone regimen. 2. Ultrashort opiate detoxification during general anaesthesia using high doses of naloxone. In an open trial 15 patients were treated with staggered doses of naloxone while under tiapride. The various discomforts were satisfactorily reduced, and the detoxification syndrome was limited to 50 hours. In a second open trial 6 patients were administered 10 mg naloxone under general anaesthesia. All naloxone induced withdrawal syndromes can be suppressed by barbiturate anaesthesia. They do not appear even after the effect of the anaesthesia wears off if the patient is kept on a naloxone regimen as long as opiates remain present in the circulatory system. Both methods shorten detoxification treatment and provide smooth transition to a naltrexone maintenance programme.
Psychiatrische Universitätsklinik.
N
N
Loimer
O
O
Presslich
K
K
Lenz
D
D
Pfersmann
R
R
Schmid
G
G
Fodor
G
G
Aschauer
D000328:Adult; D000771:Anesthesia, Intravenous; D001549:Benzamides / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006556:Heroin Dependence / Q000534:rehabilitation*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008723:Methohexital; D009021:Morphine Dependence / Q000534:rehabilitation*; D009270:Naloxone / Q000008:administration & dosage / Q000627:therapeutic use*; D013976:Tiapamil Hydrochloride / Q000008:administration & dosage / Q000627:therapeutic use*
D001549:Benzamides; D009270:Naloxone; D008723:Methohexital; D013976:Tiapamil Hydrochloride
Die "induzierte Entzugsbehandlung" bei Opiatabhängigen--ein neues Therapiekonzept.