Structure-activity relationships in a series of piperazine-2,3-dione containing penicillins and cephalosporins. II. Derivatives substituted at N(4) of the piperazine ring.
The structure-activity relationships within a series of penicillins and cephalosporins containing an N(4)-substituted piperazine-2,3-dione moiety in the C(6)/C(7)-beta-side chain are discussed.
Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Surrey, UK.
F P
FP
Harrington
S J
SJ
Knott
P J
PJ
O'Hanlon
R
R
Southgate
D002511:Cephalosporins / Q000138:chemical synthesis / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000138:chemical synthesis / Q000494:pharmacology*; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology*; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
D002511:Cephalosporins; D010406:Penicillins; D010879:Piperazines