Reversed effects between crude and processed ginger extracts on PGF2 alpha-induced contraction in mouse mesenteric veins.
The effects of crude and processed ginger extracts and pungent components, S-(+)-[6]-gingerol and [6]-shogaol, on noradrenaline (NA)- and prostaglandin (PG) F2 alpha-induced contraction were investigated using mouse mesenteric veins. Both spicy constituents inhibited the contractile responses to NA. Crude ginger extract and S-(+)-[6]-gingerol potentiated the PGF2 alpha-induced contraction, whereas processed ginger extract and [6]-shogaol inhibited the contraction.
Pancho
L R
LR
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Kimura
I
I
Unno
R
R
Kurono
M
M
Kimura
M
M
D000818:Animals; D002396:Catechols / Q000494:pharmacology; D015237:Dinoprost / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008642:Mesenteric Veins / Q000187:drug effects; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D013237:Stereoisomerism
D002396:Catechols; D005233:Fatty Alcohols; D010936:Plant Extracts; C040115:shogaol; C007845:gingerol; D015237:Dinoprost