[Effect of several inhalation anesthetics on ectopic cardiac automaticity. Intervention of the calcium ion].
The effect of halothane, enflurane and isoflurane (at concentrations ranging from 0.1 v/v% to 5 v/v%) on ventricular automaticity induced by a local injury, has been studied in the isolated right ventricle of the rat. Both, halothane and isoflurane, effectively reduces ventricular frequency at all concentrations tested. On the contrary, enflurane (0.3, 0.5 and 1 v/v%) increases ventricular automaticity. The effect of enflurane was either potentiated or reduced respectively in the presence of lower or higher calcium concentrations.
Cárceles Barón
M D
MD
Miralles Pardo
F S
FS
Laorden Carrasco
M L
ML
Hernández Cascales
J
J
D000769:Anesthesia, Inhalation; D000818:Animals; D002118:Calcium / Q000502:physiology; D004737:Enflurane / Q000494:pharmacology*; D005260:Female; D006221:Halothane / Q000494:pharmacology*; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D004737:Enflurane; D007530:Isoflurane; D002118:Calcium; D006221:Halothane
Efecto de diferentes anestésicos inhalatorios sobre el automatismo cardíaco ectópico. Intervención del ion calcio.