der(1)t(1;9): a specific chromosome abnormality in polycythemia vera? Cytogenetic and in situ hybridization studies.
Two patients with polycythemia vera and an extra der(1)t(1;9) chromosome are reported. In one patient this was found as the sole abnormality. The other patient originally presented with trisomy 9 but later developed an extra der(1) during the further course of the disease with disapperance of the extra chromosome 9. In situ hybridization studies on this latter patient proved that the centromere of chromosome 1 was involved in the formation of the derivative chromosome.
Department of Human Genetics, State University of Leiden, The Netherlands.
J I
JI
den Nijs van Weert
G C
GC
Beverstock
T
T
Kievits
H L
HL
Haak
F C
FC
Havik-Bogaard
C H
CH
Leeksma
D000328:Adult; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002899:Chromosomes, Human, Pair 9; D015342:DNA Probes; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D011087:Polycythemia Vera / Q000235:genetics*; D014178:Translocation, Genetic
D015342:DNA Probes; D005819:Genetic Markers