Sequences flanking the repeat arrays of human minisatellites: association with tandem and dispersed repeat elements.
We present DNA sequences flanking cloned hypervariable human minisatellites. In addition to providing confirmatory evidence that minisatellites cluster with other tandem repeats, these flanking sequences contain a high frequency of interspersed repetitive elements. These elements include a retroviral LTR-like sequence, from which one of the minisatellites appears to have expanded, and a recently described short interspersed repeat. We present our own findings concerning this element, in particular that those examples studied do not show significant evolutionary conservation, despite suggestions that the element may have a cis-acting function.
Department of Genetics, University of Leicester, UK.
J A
JA
Armour
Z
Z
Wong
V
V
Wilson
N J
NJ
Royle
A J
AJ
Jeffreys
D001483:Base Sequence; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D004276:DNA, Satellite / Q000235:genetics*; D005796:Genes; D006242:Haptoglobins / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D010957:Plasmids; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping
D004276:DNA, Satellite; D006242:Haptoglobins