[Intratesticular stimulation of spermatogenesis].
The possibility to exert local effect on suppressed spermatogenesis in patients with different forms of secretory sterility is presented. To this end, the authors created an experimental model of 10-minute acute ischemia in mouse testis. Destructive changes in the testicular parenchyma after the 3., 9., 22. and 30 day were observed and described. Testosterone concentration in the tissues of the ischemic and the contralateral testis was determined by highly effective liquid chromatography. It is concluded that saturation of the interstitium with androgens may avert irreversible postischemic sequelae in the testis. At first chorion gonadotropin and testosterone, but later on Sustanon-250 with prolonged action, were used as protectors. This experimental study is a contribution both to the investigation of spermatogenesis physiology and disturbances and to the refinement of the treatment of secretory forms of male sterility.
Goriunov
V G
VG
Skitotomidi
V L
VL
Kudriatsev
Iu V
IuV
D000818:Animals; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D004338:Drug Combinations / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy / Q000209:etiology; D007511:Ischemia / Q000150:complications / Q000188:drug therapy; D008297:Male; D051379:Mice; D013091:Spermatogenesis / Q000187:drug effects*; D013268:Stimulation, Chemical; D013737:Testis / Q000098:blood supply / Q000187:drug effects*; D013739:Testosterone / Q000008:administration & dosage / Q000031:analogs & derivatives; D013997:Time Factors
D006063:Chorionic Gonadotropin; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D013739:Testosterone
Intratestikularno stimulirane na spermatogenezata.