Activity of amine-stannous fluoride combination and chlorhexidine against some aerobic and anaerobic oral bacteria.
The in vitro susceptibility of 128 bacterial strains was tested to amine fluoride-stannous fluoride (AmF + SnF) and chlorhexidine (CHX) solutions. Actinobacillus actinomycetemcomitans, Streptococcus mutans, and Bacteroides intermedius were among the species investigated. The 50% and 90% minimal inhibitory concentrations (MICs) were assessed by an agar dilution method. The MIC ranges for A. actinomycetemcomitans were 2-32 micrograms/ml for CHX and 0.25-64 micrograms/ml for AmF + SnF. The respective values for S. mutans were 0.5-8 micrograms/ml (CHX) and 2-8 micrograms/ml (AmF + SnF); and 4-8 micrograms/ml (CHX) and 2-4 micrograms/ml (AmF + SnF) for B. intermedius. Streptococcus faecalis and Staphylococcus aureus were most resistant of the control strains (MIC 64 micrograms/ml to CHX and 32 micrograms/ml to AmF + SnF, respectively). Thus, both solutions tested exerted a definite inhibitory action on the dental plaque pathogens studied.
Meurman
J H
JH
Jousimies-Somer
H
H
Suomala
P
P
Alaluusua
S
S
Torkko
H
H
Asikainen
S
S
D000188:Actinobacillus / Q000187:drug effects*; D000588:Amines / Q000494:pharmacology*; D001439:Bacteroides / Q000187:drug effects*; D002710:Chlorhexidine / Q000494:pharmacology*; D005459:Fluorides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000382:microbiology; D013295:Streptococcus mutans / Q000187:drug effects*; D014002:Tin Fluorides / Q000494:pharmacology*
D000588:Amines; D014002:Tin Fluorides; D005459:Fluorides; D002710:Chlorhexidine