Intracerebroventricular administration of bombesin inhibits biliary and gastric secretion in the rat.
The effect of intracerebroventricular (ICV) bombesin on bile and gastric acid secretion was examined in the rat. ICV bombesin (10 micrograms in 10 microliters) inhibited basal biliary volume by 27% and bile bicarbonate by 52% of control values, while gastric acid secretion was decreased by 75%. These results provide evidence for central mechanisms for the control of gastrointestinal function.
Department of Surgery, University of Texas Medical Branch, Galveston 77550.
C Z
CZ
Yao
D G
DG
MacLellan
J C
JC
Thompson
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism*; D001839:Bombesin / Q000008:administration & dosage / Q000494:pharmacology*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D005744:Gastric Acid / Q000378:metabolism*; D005750:Gastric Juice / Q000187:drug effects*; D007276:Injections, Intraventricular; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D001839:Bombesin