Assignment of retinoblastoma susceptibility gene to mouse chromosome 14.
A human cDNA probe was used to screen a panel of mouse-Chinese hamster somatic cell hybrids to determine the chromosomal location of the retinoblastoma susceptibility gene (Rb-1) in mouse. The Rb-1 gene mapped to mouse chromosome 14. Thus, the retinoblastoma susceptibility gene is syntenic with esterase 10 (the mouse homolog of human esterase D). The chromosomal assignment of the mouse Rb-1 gene was further confirmed by using the same probe to study mouse-rat microcell hybrids. Since the human retinoblastoma susceptibility gene (RB1) along with the gene for esterase D is on chromosome 13q14, these data indicate this linkage group is conserved in man and mouse.
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.
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CL
Hsieh
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Lee
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Lee
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Killary
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Lalley
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Naylor
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D005796:Genes; D006822:Hybrid Cells; D051379:Mice / Q000235:genetics*; D012175:Retinoblastoma / Q000235:genetics*