[Hodgkin's disease in patients with infection caused by the human immunodeficiency virus. Study of 9 cases].
Nine young males with Hodgkin's disease (HD) and antibodies against the human immunodeficiency virus were evaluated. They had been diagnosed since 1984 in three Madrid hospitals: Hospital 12 de Octubre, Hospital Ramón y Cajal, and Clínica Puerta de Hierro. Eight patients were intravenous heroin abusers and one was homosexual. In 8 patients (88.8%) HD presented in advanced stages (III and IV), and in 5 cases (55.5%) the histology corresponded to mixed cell type. Four patients (44.4%) developed opportunistic infections. In the immunological study a reduction of CD4+ lymphocytes below 0.4 X 10(3)/l was found in 5 of 7 patients (71.4%), and an inversion of CD4+/CD8+ ratio in 6 of 7 patients (85.7%). The response to therapy was poor. Five patients died (55.5%). In 4, the direct cause of death was an opportunistic infection. The reasons why we think that HD in patients with HIV infections should be considered as indicating acquired immunodeficiency syndrome are discussed.
R
R
Rubio García
M
M
Yebra Bango
M
M
Alvarez de Mon Soto
R
R
Costa Pérez-Herrero
P
P
España Saz
L
L
Torroba Alvarez
L
L
Buzón Rueda
M
M
Serrano Comino
A
A
Durántez Martínez
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D015483:HIV Antibodies / Q000276:immunology; D006679:HIV Seropositivity / Q000276:immunology; D006689:Hodgkin Disease / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008297:Male
D015483:HIV Antibodies
Enfermedad de Hodgkin en pacientes con infección por el virus de la inmunodeficiencia humana. Estudio de 9 casos.