Efficacy of an in-feed ivermectin formulation against gastrointestinal helminths, lungworms, and sarcoptic mites in swine.
The efficacy of ivermectin as an in-feed formulation was evaluated against naturally acquired gastrointestinal helminths, lungworms, and sarcoptic mites (experiment 1; n = 24) and against induced infection with intestinal nematodes (experiment 2; n = 24) in pigs. Treatments consisted of ivermectin administered in feed at concentrations calculated to provide 100 or 200 micrograms/kg of body weight/d for 7 days or of nonmedicated feed (controls) for 7 days. At concentration of 100 micrograms of ivermectin/kg/d, efficacy against naturally acquired infections was 97.7% for Ascaris suum, 97.8% for Metastrongylus spp, greater than 99% for Oesophagostomum spp, 100% for Macracanthorhynchus hirudinaceus, and 89.7% for Ascarops strongylina. Against induced infections (fourth-stage larvae), efficacy was 100% for A suum and 96.9% for Oesophagostomum spp. At concentration of 200 micrograms of ivermectin/kg/d, efficacy against naturally acquired infections was 100% for A suum, Hyostrongylus rubidus, Metastrongylus spp, and Ascarops strongylina; greater than 99% for Oesophagostomum spp; and 85.9% for Macracanthorhynchus hirudinaceus. Against induced infections (fourth-stage larvae), efficacy was 100% for A suum and 95% for Oesophagostomum spp. At concentrations of 100 and 200 micrograms of ivermectin/kg/d, efficacy against Sarcoptes scabiei var suis was evidenced by elimination of the mite by posttreatment day 14.
Animal Science Research, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065.
R
R
Alva-Valdes
D H
DH
Wallace
A G
AG
Foster
G F
GF
Ericsson
J W
JW
Wooden
D000821:Animal Feed; D000818:Animals; D005260:Female; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D008174:Lung Diseases, Parasitic / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D008297:Male; D009349:Nematode Infections / Q000469:parasitology / Q000662:veterinary*; D011897:Random Allocation; D012532:Scabies / Q000188:drug therapy / Q000662:veterinary*; D013552:Swine / Q000469:parasitology; D013553:Swine Diseases / Q000188:drug therapy*
D007559:Ivermectin