Acute thermoregulatory responses of the immature rat to warming by low-level 2,450-MHz microwave radiation.
Rats were tested at 6-7 days of age to determine thermoregulatory responses to microwave exposure (2,450-MHz; continuous wave). Each animal was partially restrained in a cylindrical holder and irradiated at a power density of either 5 or 20 mW/cm2 [specific absorption rate = 0.60 (W/kg)/(mW/cm2)] at a cold ambient temperature (Ta). Following a 1-hour thermal equilibration period, each rat was monitored at 1-min intervals during 1-hour microwave exposure and 1-hour recovery periods. Colonic temperature (Tco), determined with a Vitek probe, and metabolic heat production (M), derived from measures of oxygen consumption, were sampled and recorded during these periods. Tco increased significantly above initial level at both power densities and reached a plateau after 45 min of microwave exposure. Tco doubled with a four-fold increase in microwave intensity. Prior to exposure, M was elevated in response to cold Ta and remained unchanged during exposure at 5 mW/cm2, but decreased 7.2 W/kg during exposure at 20 mW/cm2. The results indicate that the hypothermic rat pup can be effectively warmed by low-level microwave irradiation and is capable of altering metabolism in response to such heating.
John B. Pierce Foundation Laboratory, Yale University School of Medicine, New Haven, Conn.
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Spiers
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Adair
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Baummer
D000818:Animals; D000833:Animals, Suckling; D001831:Body Temperature / Q000528:radiation effects; D001833:Body Temperature Regulation / Q000528:radiation effects*; D006358:Hot Temperature; D008872:Microwaves; D051381:Rats