Vinblastine-C4 alkyl maleoyl and amino acid maleoyl derivatives: I. Chemistry and physicochemical data.
Vinblastine-C4 acyl derivatives were synthesized by linking alkyl maleoyl or amino acid maleoyl compounds through an ester linkage at the C4 position of the vindoline moiety of vinblastine. The condensation of the above mentioned compounds was performed by the mixed anhydride method. Their synthesis, yields and physiochemical data are reported.
S.A IRE-CELLTARG, Fleurus, Belgium.
K S
KS
Rao
J A
JA
Hannart
A
A
Trouet
D055598:Chemical Phenomena; D002621:Chemistry; D014747:Vinblastine / Q000031:analogs & derivatives*
D014747:Vinblastine