[Relations between pressure overload and early signs of cardiac involvement in arterial hypertension].
In arterial hypertension the indexes of left ventricular hypertrophy are not related to resting blood pressure, whereas a positive association with exercise blood pressure has been observed. It has not been investigated a possible relationship between response to stress and left ventricular diastolic function, the latter being early involved in arterial hypertension even before the development of ventricular hypertrophy. The present study was aimed at assessing a possible relationship between blood pressure response to dynamic exercise and index of left ventricular mass, systolic and diastolic function in a group of untreated hypertensives. fourty hypertensives aged 16-56 years were studied, 27 with mild hypertension and 13 with moderate or severe hypertension. The control group consisted of 23 normotensive healthy subjects, aged 14-40 years. All the subjects underwent a maximum-graded bicycle exercise in the supine position and a M-mode echocardiogram under the B-mode drive. Average values of the indexes of ventricular hypertrophy and of systolic function were overlapping in the 3 groups. Significant differences were observed in the indexes of diastolic function; with regard to normatensive controls, hypertensive subjects showed an increase in isovolumic relaxation time and rapid filling time, a decrease of isovolumic and rapid filling rates and a reduction of mitral valve closing and opening velocities.(ABSTRACT TRUNCATED AT 250 WORDS)
Radice
M
M
Alli
C
C
Di Tullio
M
M
Guiducci
D
D
Mariotti
G
G
Salmoirago
E
E
Taioli
E
E
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D004452:Echocardiography; D005080:Exercise Test; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008875:Middle Aged; D005082:Physical Exertion
Rapporto tra entità del sovraccarico pressorio e segni precoci di coinvolgimento cardiaco nell'ipertensione arteriosa.