Effect of whey proteins, their oligopeptide hydrolysates and free amino acid mixtures on growth and nitrogen retention in fed and starved rats.
The effects of alimentary whey proteins given, as whole proteins (WP), controlled trypsin and chymotrypsin hydrolysate oligopeptides (WPH), or a free amino acid mixture (AAM), on growth, nitrogen retention, and steatorrhea were assessed in 24 Wistar rats (250 to 300 g) after 72 hr of starvation and 24 to 96 hr of realimentation and in 24 controls. The three diets had the same caloric, nitrogen, vitamin, and mineral contents. Rats had free access to the liquid diets. Only rats which ate the whole diet (90 cal) were included in the study. No differences in steatorrhea and fecal nitrogen were observed. The absorption rate was over 95% on the three diets. In contrast, weight gain was statistically better on WPH (+9% after 96 hr of realimentation) than on WP (+5%) or AAM (+2%). This was associated with a statistically higher nitrogen retention at all time periods studied, which was a result of a significant lower nitrogen urinary excretion. Similar results were obtained in controls. This better growth was a result of a better protein synthesis and lower ureagenesis.
INSERM Unité 120, Le Vésinet, France.
M G
MG
Poullain
J P
JP
Cezard
L
L
Roger
F
F
Mendy
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight; D002446:Celiac Disease / Q000378:metabolism; D004044:Dietary Proteins / Q000378:metabolism*; D006128:Growth; D008297:Male; D008894:Milk Proteins / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism* / Q000652:urine; D011492:Protein Hydrolysates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism*; D000067816:Whey Proteins
D000596:Amino Acids; D001798:Blood Proteins; D004044:Dietary Proteins; D008894:Milk Proteins; D011492:Protein Hydrolysates; D000067816:Whey Proteins; D009584:Nitrogen