[Effect of neonatal androgenization on the septal neurons of the brain in female rats in early postnatal ontogeny].
Newborn female rats were androgenized, and the reaction of neurons of brain septum on excessive quantity of exogenous androgens, introduced during so-called "crucial" period of formation of centers of gonadotropic regulation of sexual cycles, has been studied in 3, 5, 7, 10, 20, 30, and 60 days old animals. Morphometry of brain septum cell nuclei revealed that most neuron nuclei shrink after androgenization. Monoamine content was significantly increased in septum nuclei of experimental animals. Neonatal androgenization led to the increased capacity of septal complex neurons to bind 3H-estradiol and to the decreased 3H-testosterone binding. The data obtained suggest that the brain septum neurons of female rats depend on sex steroids, particularly during "crucial" period of development.
Myslitskiĭ
V F
VF
D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D015306:Biogenic Monoamines / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D005260:Female; D007620:Karyometry; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D012688:Septum Pellucidum / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism; D045165:Testosterone Congeners / Q000494:pharmacology*; D014316:Tritium
D015306:Biogenic Monoamines; D045165:Testosterone Congeners; D014316:Tritium; D013739:Testosterone; D004958:Estradiol
Vliianie neonatal'noĭ androgenizatsii na neĭrony peregorodki mozga samok krys v rannem postnatal'nom ontogeneze.