[Natural HLA-A, B and DR antibodies in the serum of non-immunized men].
From 643 sera of healthy women and men in 67 a positive reaction with B lymphocytes and/or monocytes of healthy subjects was found. Forty-seven sera gave only occasional weak reaction. Twenty sera were from 18 subjects (13 men without a transfusion in the case-history 5 women with pregnancy in the case-history). In nine sera of men (= 1.40%) HLA-A, B cytotoxins, usually bi-or multispecific, were detected, in four sera of men (= 0.62%) HLA-DR antibodies were present in two instances their specificity was assessed: anti-HLA-DR7, anti-HLA-DRI + weak DR4. All these antibodies can be considered natural. In three women HLA-A, B cytotoxins were detected, in two monocytic antibodies. From the results ensues that it is useful to test women donors with a case-history of pregnancy for the presence of HLA-antibodies. The author discusses whether antibodies revealed in sera of 13 men are really natural or whether they developed for other reasons.
A
A
Májský
D000906:Antibodies / Q000032:analysis*; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D015234:HLA-A Antigens / Q000276:immunology; D015235:HLA-B Antigens / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007114:Immunization; D008297:Male
D000906:Antibodies; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens
Prirozené HLA-A, B, DR protilátky v sérech neimunizovaných muzů.