[Synthesis and antisecretory and anti-ulcer activity of new 4,6-diarylpyridazinones].
It has been possible to prepare from 4,6-diaryl pyridazinones a series of derivatives substituted in the 2-position and having urea moiety via the addition of free amines into methylisocyanate. Their gastric anti-secretory and anti-ulcer activities were evaluated. The compounds with an N-2 ethyl chain on the pyridazinone ring (IVa, IVd, IVg) were the most active derivatives.
Coudert
P
P
Rubat
C
C
Tronche
P
P
Bastide
P
P
Bastide
J
J
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000897:Anti-Ulcer Agents; D011724:Pyridazines
Synthèse et activités antisécrétoire et antiulcéreuse de nouvelles N-uréidoalkyl pyridazinones.