Single-dose pharmacokinetics of flurbiprofen granules and tablets in healthy volunteers.
The bioavailability of granules and tablet flurbiprofen in 100 mg single dose was crossover compared in 6 healthy volunteers (mean aged 26.8 years). The granules showed an earlier peaktime and a lower maximum concentration than the tablet. Area under the curve and half-time in terminal phase were similar, with the granule relative bioavailability of 0.98.
Medical Dept., Boots-Formenti, Milan, Italy.
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Benvenuti
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Gambaro
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Lodi
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Scaroni
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Bandi
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Valenti
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D007202:Indicators and Reagents; D007408:Intestinal Absorption; D008297:Male; D011208:Powders; D011422:Propionates / Q000493:pharmacokinetics*; D013607:Tablets
D007202:Indicators and Reagents; D011208:Powders; D011422:Propionates; D013607:Tablets; D005480:Flurbiprofen