New anticancer agents: chiral isomers of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7-car bamate .
Racemic ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7- carbamate (1a) has shown antitumor activity in a variety of in vivo experiments. The preparation of the R and S isomers gave compounds with significant differences in potency in several biological tests.
Temple
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Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35255-5305.
Rener
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GA
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D003078:Colchicine / Q000378:metabolism / Q000627:therapeutic use; D004357:Drug Synergism; D007536:Isomerism; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D011719:Pyrazines / Q000138:chemical synthesis* / Q000378:metabolism / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000378:metabolism; D014750:Vincristine / Q000378:metabolism / Q000627:therapeutic use
D000970:Antineoplastic Agents; D011719:Pyrazines; D014404:Tubulin; D014750:Vincristine; C047151:NSC 269416; D003078:Colchicine