Immunoenhancement with combined rabies and aluminium-adjuvanted tetanus vaccines.
The effect of combining tetanus toxoid in the same syringe with purified Vero cell rabies vaccine (PVRV) was investigated in the 2-1-1 regimen of PVRV. The 2-1-1 regimen alone was as immunogenic as the five-dose regimen, while saving one dose of vaccine and two clinic visits. When aluminium hydroxide-adsorbed tetanus toxoid was used to dissolve PVRV on days 0 (one of the two doses) and 21, the anti-rabies antibody was significantly increased. Aluminium-free tetanus toxoid was ineffective, suggesting that immunoenhancement was due to aluminium adjuvant. In addition, anti-tetanus antibody was unaffected and the side-effects were not increased by such mixing.
Science Division, Thai Red Cross Society, Bangkok, Thailand.
P
P
Phanuphak
P
P
Khaoplod
B
B
Sriwanthana
T
T
Phanpanich
S
S
Wongurai
M
M
Roumiantzeff
D000276:Adjuvants, Immunologic; D000328:Adult; D000536:Aluminum Hydroxide / Q000276:immunology*; D000914:Antibodies, Viral / Q000096:biosynthesis; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011818:Rabies / Q000276:immunology / Q000628:therapy; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology*; D013745:Tetanus Toxoid / Q000008:administration & dosage / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D011819:Rabies Vaccines; D013745:Tetanus Toxoid; D000536:Aluminum Hydroxide