Monomeric (7S) and polymeric (19S) IgM anti-delta in acute and chronic delta infections.
The chromatographic profiles of IgM anti-delta in 45 acute and 24 chronic delta patients were analyzed by fast protein liquid chromatography (FPLC). Predominance of 19S IgM anti-delta was observed in the sera of 100 percent of coinfected and 62% of superinfected patients. In contrast, 7S IgM anti-delta was predominant in 83% of patients with chronic hepatitis delta. The study of the chromatographic profiles of IgM anti-delta in the development of the disease showed an association between the process of chronic delta-infection and the failure of 7S IgM anti-delta monomers to form 19S pentamers. The results showed that the test for 7S and 19S IgM anti-delta could be useful for differential diagnosis of acute and chronic hepatitis delta infection and for determining the prognosis of acute delta infection.
Department of Viral Hepatitis and Clinical Virology, D.I. Ivanovsky Institute of Virology, Academy of Medical Sciences USSR, Moscow.
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Vyazov
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IN
Khlopova
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Mesyanzhinov
D000208:Acute Disease; D002851:Chromatography, High Pressure Liquid; D002908:Chronic Disease; D003699:Hepatitis D / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism*; D011379:Prognosis; D013997:Time Factors
D007075:Immunoglobulin M; C024242:polymeric IgM