Racial differences in drug response: isoproterenol effects on heart rate in healthy males.
It was the purpose of this study to investigate racial alterations in beta-adrenoceptor response. Two groups of healthy, male volunteers gave their consent. There were eight black Americans (mean age, 26.1 +/- 2.5 years) and eight white/Caucasian Americans (mean age 24.4 +/- 1.8 years). Each subject underwent an isoproterenol sensitivity test. There was a significant (P less than 0.05) decrease in the ratio of Emax to ED50 in the white group (25.3 +/- 6.4) compared with the black group (37.1 +/- 12.4). Over the dose range of 0.1 to 1.0 micrograms there was a significant increase in response at both the 0.25- and the 0.5-microgram dose (P less than 0.05), with the black American group appearing to respond with a greater rate of rise in heart rate following the initial doses.
Rutledge
D R
DR
Department of Pharmacy Practice, Wayne state University, College of Pharmacy Detroit, Michigan 48202.
Cardozo
L
L
Steinberg
J D
JD
D000328:Adult; D044383:Black People; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D008954:Models, Biological; D044469:Racial Groups; D044465:White People; D001741:Black or African American
D007545:Isoproterenol