Effect of T-activin on the course of experimental infection with Taenia crassiceps (Zeder, 1800) in mice.
T-activin--an immunomodulating preparation of polypeptidic character prepared from calf thymus--was used for influencing the course of infection in a model system mouse-Taenia crassiceps. A single s.c. application of 100 micrograms of T-activin at various intervals before and after infection resulted in a marked decrease in the number of cysticerci in peritoneal cavities of experimental mice (by 47.1-93.6%) compared to the controls. After s.c. application of T-activin and i.p. injection of antigen (crude T. crassiceps larvae homogenate from mice) the decrease in the cystricercus number was still more pronounced than in the mouse groups receiving only T-activin or homogenate (by 76.9% in comparison with 65.5% and 17.0%, respectively). A combination of T-activin with crude T. crassiceps homogenate from rats did not produce the same effect in experimental mice. The protective effect of individual combinations of T-activin with the homogenate does not correlate with the antibody level in the serum of infected mice.
Hermánek
J
J
Institute of Parasitology, Czechoslovak Academy of Sciences, Ceské Budĕjovice.
Prokopic
J
J
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D051379:Mice; D008813:Mice, Inbred ICR; D010455:Peptides / Q000627:therapeutic use*; D010529:Peritoneal Cavity / Q000469:parasitology; D013621:Taenia / Q000276:immunology; D013622:Taeniasis / Q000628:therapy*; D013949:Thymus Extracts / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D000909:Antibodies, Helminth; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin