Family history of anxiety disorders in control subjects with lactate-induced panic attacks.
The authors infused 45 control subjects with sodium lactate. Eight of 10 subjects with lactate-induced panic attacks and 26 of 35 without panic attacks were interviewed. An investigator, blind to the outcome of the infusion study, obtained family histories of 160 relatives. There was a high prevalence of anxiety disorders among first-degree relatives of subjects with panic attacks. There was no significant difference in the prevalence of mood disorders and substance abuse between first-degree relatives of subjects with (N = 45) and without (N = 115) panic attacks. The results suggest that individuals with a family history of anxiety disorders may be vulnerable to lactate-induced panic attacks.
Balon
R
R
Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI.
Jordan
M
M
Pohl
R
R
Yeragani
V K
VK
D000328:Adult; D001008:Anxiety Disorders / Q000139:chemically induced* / Q000235:genetics; D003866:Depressive Disorder / Q000235:genetics; D005190:Family; D005239:Fear; D005260:Female; D006801:Humans; D007773:Lactates; D019344:Lactic Acid; D008297:Male; D010200:Panic; D019966:Substance-Related Disorders / Q000235:genetics
D007773:Lactates; D019344:Lactic Acid