9-Methyl-7-bromoeudistomin D, a potent inducer of calcium release from sarcoplasmic reticulum of skeletal muscle.
The Ca2+-releasing action of several derivatives of eudistomin D isolated from a marine tunicate was compared with that of caffeine. It was found that 9-methyl-7-bromoeudistomin D was approximately 1000 times more potent than caffeine in causing Ca2+ release from the sarcoplasmic reticulum.
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
J
J
Kobayashi
M
M
Ishibashi
U
U
Nagai
Y
Y
Ohizumi
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002243:Carbolines / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004563:Electrochemistry; D008958:Models, Molecular; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship
D002243:Carbolines; C060741:9-methyl-7-bromoeudistomin D; D002118:Calcium