A succinylcholine-like action of an Ipomoea carnea Jacq subsp. fistulosa (Mart. ex choisy) extract.
An aqueous alcoholic extract of Ipomoea carnea subsp. fistulosa was tested in vitro on isolated preparations of the frog rectus abdominis muscle and the rabbit perfused heart as well as in vivo in the chicken. The extract and succinylcholine (suxamethonium) contracted the frog rectus abdominis muscle and this action was blocked by tubocurarine, 1.5 micrograms/ml. Both extract and succinylcholine produced bradycardia of the rabbit heart which was antagonized by atropine, 20 micrograms/ml. Like succinylcholine, the extract produced spastic paralysis in chickens. It is suggested that the extract possesses a depolarizing action similar to that of succinylcholine.
Abdelhadi
A A
AA
Department of Pharmacology, Faculty of Medicine, University of Juba, Sudan.
el Kheir
Y M
YM
Hassan
T
T
D000818:Animals; D001001:Anura; D002645:Chickens; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010947:Plants, Toxic; D011817:Rabbits; D013390:Succinylcholine / Q000494:pharmacology*
D010936:Plant Extracts; D013390:Succinylcholine