Effects of topical anesthetic agents on Campylobacter pylori.
The susceptibility of Campylobacter pylori was determined for the two topical anesthetic agents commonly used prior to gastroscopy. Campylobacter pylori proved to be extremely sensitive to the anti-infective activity of benzocaine, the active ingredient in most commonly used topical anesthetic agents, with minimum inhibitory concentrations of 0.14 mg/ml. However, lidocaine-containing agents did not interfere with the growth of this microorganism. Specifically, in patients with histologic evidence of C. pylori, the bacterium was recovered from significantly more patients anesthetized with lidocaine than with benzocaine. Thus, the use of benzocaine-containing topical anesthetic agents limits recovery of Campylobacter pylori from clinical specimens and might account for the low colonization rates reported in some recent publications.
Department of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
S J
SJ
Czinn
H S
HS
Carr
W T
WT
Speck
D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001566:Benzocaine / Q000494:pharmacology*; D002167:Campylobacter / Q000187:drug effects*; D002169:Campylobacter Infections / Q000175:diagnosis; D004724:Endoscopy; D005767:Gastrointestinal Diseases / Q000175:diagnosis; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D008012:Lidocaine; D001566:Benzocaine