Effect of an inhaled mast cell stabiliser, N-acetyl-aspartyl-glutamate (Zy15109) on allergen-induced immediate bronchoconstriction.
We have studied the effect of a mast cell stabiliser, the magnesium salt of N-acetyl aspartyl glutamic acid (NAAGA) on allergen-induced immediate bronchoconstriction in 12 atopic subjects. Inhaled NAAGA, at a dose of 60 mg thrice daily for 1 week, offered no protective effect on the airways against allergen challenge when compared with a matched placebo. The drug was well tolerated with no adverse effects observed.
Lai
C K
CK
Immunopharmacology Group, Southampton General Hospital.
Gregory
J
J
Holgate
S T
ST
D000328:Adult; D000485:Allergens / Q000494:pharmacology; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology; D001993:Bronchodilator Agents; D004151:Dipeptides / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D011897:Random Allocation; D013997:Time Factors
D000485:Allergens; D001993:Bronchodilator Agents; D004151:Dipeptides; C027172:isospaglumic acid