[Experimental renal insufficiency in rabbits produced by the intrarenal injection of cyanoacrylic ester].
Through a percutaneous intrarenal injection of 2 ml cyanoacrylic ester to each kidney, acute renal failure was induced in 10 experimental rabbits. Seven of the animals died as a consequence of uremia before a period of 64 hours. The other three remained alive for 96 hours although suffering from stable renal failure. Cyanoacrylic ester solidifies immediately after injection, leading to a hardened body which fills the renal pelvis, ureters and also the renal vessels. Each injection induces hydronephrosis and necrotic-hemorrhagic lesions, and infarcts in the case of vascular injection. With this simple technique immediate acute renal failure can be obtained experimentally without causing trauma or involving extrarenal structures.
Jimeno Carruez
A
A
de Alvaro
F
F
Ibañez
E
E
Pérez Díaz
V
V
Largo
E
E
Anllo
F
F
Gómez de la Torre
R
R
Ortiz
O
O
D000179:Acrylates / Q000633:toxicity*; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000269:Adhesives / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D003487:Cyanoacrylates / Q000008:administration & dosage / Q000633:toxicity*; D007267:Injections; D008297:Male; D008689:Methacrylates / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits
D000179:Acrylates; D000269:Adhesives; D003487:Cyanoacrylates; D008689:Methacrylates; C038690:Loctite
Insuficiencia renal experimental en conejos por inyección intrarrenal de ester cianoacrílico.