[Peptidoglycan modification of Staphylococcus aureus P18 strain after use of 6 active antibiotics on the bacterial wall].
Six antibiotics active on the cell-wall were tested against a methicillin resistant Staphylococcus aureus P18 strain at the start of exponential growth rate. The concentration was four-fold the MIC determined in a non-hypersaline liquid medium. The peptidoglycan amino-acid content of the various cell wall samples was determined. An antibiotic-free S. aureus P18 and the methicillin-sensitive Cowan I. S. aureus strain were used a controls. Beta lactam antibiotic treatment, oxacillin and cephalothin, induced an increase of alanine content which suggests that only secondary-transpeptidation did not occur. Similar results were obtained using vancomycin. Amino-acid content was not modified by bacitracin, which is in agreement with the results expected. The results obtained for fosfomycin and cefamandole were not easy to interpret.
Najioullah
F
F
Laboratoire de Bactériologie, Faculté de Médecine Alexis-Carrel, Lyon.
Freney
J
J
Pellon
G
G
Meugnier
H
H
Dorleac
E
E
Durand
C
C
Fleurette
J
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002473:Cell Wall / Q000187:drug effects; D004352:Drug Resistance, Microbial; D008712:Methicillin / Q000494:pharmacology; D010457:Peptidoglycan / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D010457:Peptidoglycan; D008712:Methicillin
Modification du peptidoglycane de la souche de Staphylococcus aureus P18 après utilisation de six antibiotiques actifs sur la paroi bactérienne.