Blockade of the nootropic action of piracetam-like nootropics by adrenalectomy: an effect of dosage?
The present experiments demonstrate that the absence of any memory-improving action of nootropics in adrenalectomized animals cannot be ascribed to an effect of dosage. Doses of 1, 10, 100, 1000 and 3000 mg/kg p.o. of piracetam, oxiracetam, aniracetam or pramiracetam are ineffective in adrenalectomized mice.
Pharmaceutical Research Department, CIBA-GEIGY Limited, Basle, Switzerland.
C
C
Mondadori
T
T
Ducret
F
F
Petschke
D000315:Adrenalectomy; D000818:Animals; D001143:Arousal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D010889:Piracetam / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology; D011760:Pyrrolidinones / Q000494:pharmacology*; D012153:Retention, Psychology / Q000187:drug effects
D011759:Pyrrolidines; D011760:Pyrrolidinones; C038438:pramiracetam; C036466:aniracetam; C040619:oxiracetam; D010889:Piracetam