Paraproteinaemias and platelet aggregation: role of whole blood aggregometry.
Whole blood and optical platelet aggregation were measured in normals and in patients with paraproteinaemias; extent of aggregation was correlated with paraprotein concentrations in patients and in normals after addition of different doses of paraproteins; threshold aggregating concentrations of several agonists were also determined in whole blood and in PRP from both groups of subjects. The results indicate that patients with macromolecular monoclonal component bear a "hyperaggregable" state which can be probably ascribed also to plasma hyperviscosity and which is better detected with the impedance aggregometer.
Schinco
P C
PC
Department of Medicine and Experimental Oncology, University of Turin, Molinette Hospital, Italy.
Fusaro
A
A
Marranca
R
R
Battaglio
S
S
Bazzan
M
M
Pannocchia
A
A
Tamponi
G
G
Pileri
A
A
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001095:Arachidonic Acids / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000032:analysis; D066298:In Vitro Techniques; D010265:Paraproteinemias / Q000097:blood*; D010266:Paraproteins / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*
D001095:Arachidonic Acids; D007132:Immunoglobulin Isotypes; D010266:Paraproteins; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine