Influence of milk on the bioavailability of doxycycline--new aspects.
This study was conducted to examine the pharmacokinetics of doxycycline in nine healthy volunteers who had fasted overnight. Single-dose cross-over design was used. Each subject received orally 0.2 g doxycycline. The subjects swallowed the antibiotic capsules with 300 ml of water or 300 ml of fresh milk. Simultaneous ingestion of milk diminished the peak plasma concentration by 24% and the absorption by 9-53% (mean 30%). It is concluded that, like the other tetracyclines, doxycycline should not be administered together with milk.
Institut für Klinische Pharmakologie, Medizinische, Akademie Magdeburg, DDR.
F P
FP
Meyer
H
H
Specht
B
B
Quednow
H
H
Walther
D000042:Absorption; D000328:Adult; D000818:Animals; D001682:Biological Availability; D004318:Doxycycline / Q000097:blood / Q000493:pharmacokinetics*; D005215:Fasting; D005260:Female; D006801:Humans; D008297:Male; D008892:Milk; D014867:Water
D014867:Water; D004318:Doxycycline