Vitamin D, desferrioxamine and aluminum-induced bone disease in uremic rats.
The effect of 100 ng 1 alpha-OH vitamin D/week alone and in combination with desferrioxamine (DFO), 150 mg/week, was evaluated in aluminum loaded uremic rats. Vitamin D (Vit D) caused an increase of Al in muscle and a decrease in serum Al. Bone histology showed mineralization defect and an increase in bone mass, due to an increase in unmineralized bone, induced both by Al and Vit D administration. Treatment with DFO enhanced urinary Al excretion and lowered tissue Al, without inducing major changes of static bone histology. It is concluded that in Al-loaded uremic rats Vit D can redistribute body Al and that both Al and Vit D can cause a mineralization defect. A 6-week treatment with DFO lowers tissue Al without changing significantly static bone parameters.
Verbeelen
D
D
Department of Medicine, Akademisch Ziekenhuis, Vrije Universiteit, Brussels, Belgium.
Smeyers-Verbeke
J
J
van Hooff
I
I
de Roy
G
G
D000535:Aluminum / Q000378:metabolism / Q000506:poisoning*; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D001923:Brain Chemistry / Q000187:drug effects; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D003404:Creatinine / Q000097:blood / Q000378:metabolism; D003676:Deferoxamine / Q000494:pharmacology*; D008099:Liver / Q000032:analysis / Q000187:drug effects; D008297:Male; D009132:Muscles / Q000032:analysis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014511:Uremia / Q000097:blood / Q000150:complications / Q000378:metabolism*; D014807:Vitamin D / Q000494:pharmacology*
D014807:Vitamin D; D003404:Creatinine; D000535:Aluminum; D003676:Deferoxamine