[Clinico-immunologic characteristics of patients with pulmonary tuberculosis, psychic diseases and a congenital glucose-6-phosphate dehydrogenase deficiency].
Clinical and immunological characteristics of the tuberculosis process in patients with mental diseases and congenital deficiency of glucose-6-phosphate dehydrogenase were investigated. Enzymopathy was detected in 34 (8.9 per cent) out of 382 patients subjected to the investigation. It was shown that among the carriers of the anomalous gene, the proportion of patients with chronic destructive tuberculosis was high. The patients (91.2%) showed more frequent bacterial isolation. Despite immunotherapy, no positive changes in the immunological indices were observed in the carriers, which was attributable to decreased activity of the enzyme in the immunocompetent cells.
Insanov
A B
AB
Aliev
N A
NA
Abdullaev
F M
FM
Umniashkin
A A
AA
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications* / Q000151:congenital / Q000276:immunology; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000276:immunology
Kliniko-immunologicheskie osobennosti bol'nykh tuberkulezom legkikh, stradaiushchikh psikhicheskimi zabolevaniiami, s vrozhdennym defitsitom fermenta G-6-FDG.