[Characteristics of drug pharmacodynamics in irradiated rats].
A whole-body exposure of rats to 8 Gy radiation is ineffective in 3 days, and in 6 days, it prolongs considerably the effect and increases the pharmacological activity of hexenal, meprobamate, ethylmorphine, and amidopyrine, inhibits the activity of amidopyrine demethylase, aniline hydroxylase, NADPH-cytochrome c reductase, and reduces the content of protein, cytochromes P-450 and b5 in a microsomal liver fraction.
Khakimov
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D000208:Acute Disease; D000632:Aminopyrine / Q000493:pharmacokinetics* / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005036:Ethylmorphine / Q000493:pharmacokinetics* / Q000494:pharmacology; D006591:Hexobarbital / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D008620:Meprobamate / Q000493:pharmacokinetics* / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects; D009022:Morphine Derivatives / Q000493:pharmacokinetics*; D011833:Radiation Injuries, Experimental / Q000201:enzymology*; D051381:Rats; D013997:Time Factors
D009022:Morphine Derivatives; D000632:Aminopyrine; D008620:Meprobamate; D006591:Hexobarbital; D005036:Ethylmorphine
Osobennosti farmakodinamiki lekarstvennykh veshchestv u obluchennykh krys.