[Platelet aggregation inhibitory therapy in chronic arterial occlusive disease of the lower limbs: results of short-term clinico-instrumental study with indobufen].
Aim of our study was to evaluate the effectiveness of indobufen in the treatment of II degree stage lower limb occlusive arterial disease. Forty patients were randomly assigned to the iIndobufen (400 mg/die) treatment group or the no treatment control group (20 patients each). Doppler pressure measurement (Winsor index) and subjective symptomatology were evaluated at the time of enrollment and after one month. A significant improvement (p less than 0.01) was noted only in the treated group. We conclude that indobufen may be of therapeutic value in the treatment of peripheral occlusive arterial disease.
G
G
Landini
C
C
Poggiali
S
S
Calacoci
N
N
Marino
A
A
Rosselli
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000188:drug therapy*; D002908:Chronic Disease; D004341:Drug Evaluation; D006801:Humans; D054833:Isoindoles; D007866:Leg / Q000098:blood supply; D008875:Middle Aged; D010654:Phenylbutyrates / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011897:Random Allocation
D054833:Isoindoles; D010654:Phenylbutyrates; D010975:Platelet Aggregation Inhibitors; C020371:indobufen
La terapia antiaggregante piastrinica nelle arteriopatie obliteranti croniche degli arti inferiori: risultati di uno studio clinico-strumentale a breve termin con indobufene.