Direct evidence for calcium-induced ischemic and reperfusion injury.
Changes in cytosolic free calcium [( Ca2+]i) in the cat cortex were measured in vivo by indo-1 fluorometry during cerebral ischemia and reperfusion and were correlated to the histopathological ischemic changes. These changes were most pronounced in stroke cases with an increase in [Ca2+]i throughout the ischemic and reperfusion periods. Cases without a [Ca2+]i increase showed no histopathological change in the cortical gyrus in which [Ca2+]i was measured. The data support the hypothesis that an increase in [Ca2+]i during cerebral ischemia and reperfusion leads to neuronal damage.
Uematsu
D
D
Department of Neurology, University of Pennsylvania, Philadelphia.
Greenberg
J H
JH
Reivich
M
M
Hickey
W F
WF
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002415:Cats; D003600:Cytosol / Q000378:metabolism; D004569:Electroencephalography; D005456:Fluorescent Dyes; D002546:Ischemic Attack, Transient / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D008297:Male
D005456:Fluorescent Dyes; D002118:Calcium