Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6.
Our laboratory has recently cloned and characterized two testes-expressed loci--the Tcp-10 gene family cluster and the D17Si11 gene--that map to the proximal portion of mouse chromosome 17. Human homologs of both loci have been identified and cloned. Somatic cell hybrid lines have been used to map the human homolog of D17Si11 to the short arm of chromosome 6 (p11-p21.1) along with homologs of other genes from the (Pim-1)-(Pgk-2) region of the mouse chromosome. The human TCP 10 locus maps to the long arm of chromosome 6 (q21-qter) along with homologs of other genes from the mouse chromosome 17 region between the centromere and Pim-1. The mapping of large portions of the mouse t haplotype to unlinked regions on human chromosome 6 rules out the possibility that a t-haplotype-like chromosome could exist in humans.
Department of Molecular Biology, Princeton University, New Jersey 08544.
K B
KB
Bibbins
J Y
JY
Tsai
J
J
Schimenti
N
N
Sarvetnick
H Y
HY
Zoghbi
P
P
Goodfellow
L M
LM
Silver
D000483:Alleles; D000818:Animals; D015139:Blotting, Southern; D002460:Cell Line; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D006822:Hybrid Cells; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D051379:Mice; D008869:Microtubule-Associated Proteins; D005810:Multigene Family; D009687:Nuclear Proteins / Q000235:genetics*; D011506:Proteins; D013737:Testis / Q000648:ultrastructure*; D044767:Ubiquitin-Protein Ligases; D056427:t-Complex Genome Region
D005819:Genetic Markers; D047908:Intracellular Signaling Peptides and Proteins; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins; D011506:Proteins; C533392:TCP10L3 protein, human; C533395:Tcp10 protein, mouse; C116196:PPP1R11 protein, human; D044767:Ubiquitin-Protein Ligases