[In vitro granulomonocytopoiesis during and after treatment of acute lymphoblastic leukemia in children].
We studied the effects of antileukemic chemotherapy on the granulomonocytic precursors (CFU-GM) by the in vitro bone marrow culture method. Groups of study were: 1) 17 children with acute lymphoblastic leukemia in complete remission, under maintenance chemotherapy, and 2) 10 children who had finished the treatment. Both groups had the same treatment schedule. As a control group, we studied CFU-GM from 3 children without bone marrow lesion. The results show a diminution of the granulocyte-macrophage progenitor cells in individuals under treatment, compared with the control group, after a 14 days incubation period. The group of children out of treatment shows a higher number of progenitor cells after 7 days of incubation (mature progenitors), but number decreases after 14 days (immature progenitors). Therefore, we can deduce a toxic effect, direct or indirect, but probably sustained, of the chemotherapy on the granulomonocytic precursor cells.
Servicio de Hematología, Hospital Dr. Peset, Ciudad Sanitaria La Fé, Valencia.
P
P
León Moreno
R
R
Fernández-Delgado Cerdá
M V
MV
Amigo García
J
J
Villarroya Luna
A
A
Jubert Rosich
J
J
Donat Colomer
D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D006098:Granulocytes / Q000166:cytology* / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007223:Infant; D009000:Monocytes / Q000166:cytology* / Q000187:drug effects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy*; D013997:Time Factors
D000970:Antineoplastic Agents
Granulomonocitopoyesis in vitro durante y tras el tratamiento de las leucemias linfoblásticas agudas infantiles.