[The role of the brain monoaminergic systems in the anti-alcohol action of dermorphin and the delta-sleep peptide].
The effects of dermorphin and DSIP were studied in male Wistar rats chronically treated with ethanol. Both peptides (200 mg/kg, i. p., daily during 10 days) significantly reduced volitional alcohol intake for 3-4 weeks. These effects were associated with a marked decrease in serotonin and its metabolite 5-HIAA levels in the hypothalamus. The findings suggest that antialcoholic effects of both peptides are actualized through mechanisms involving serotoninergic system of the brain.
Gromova
E A
EA
Bobkova
N V
NV
Plakkhinas
L A
LA
Deĭgin
V I
VI
Iarova
E P
EP
D000427:Alcohol Deterrents; D000428:Alcohol Drinking / Q000187:drug effects / Q000502:physiology; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000427:Alcohol Deterrents; D015306:Biogenic Monoamines; D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin; D003701:Delta Sleep-Inducing Peptide
Rol' monoaminergicheskikh sistem mozga v protivoalkogol'nom deĭstvii dermofina i peptida del'ta-sna.