Local application of neurotensin to abdominal organs triggers cardiovascular reflexes in guinea pigs: possible mechanisms.
Intraabdominal (IAB) injections or topical application of neurotensin (NT) to the serosal surface of the ileum or stomach evoked dose-dependent increases of blood pressure and of heart rate in anesthetized guinea pigs. These effects were markedly reduced by prior animal treatment with a ganglion blocker, alpha and beta adrenoceptor blockers, as well as by exposure of the abdominal organs to lidocaine, a local anesthetic. The blood pressure and heart rate responses to IAB injections or topical application of NT to the ileum or stomach were both inhibited by animal pretreatment with capsaicin. Cervical vagotomy or atropine pretreatment did not prevent or alter the cardiovascular responses to IAB injections of NT. These results suggest the presence in some organs and/or tissues of the abdominal cavity of sympathetic, capsaicin-sensitive sensory nerve fibers which, upon stimulation by NT, produce reflex increases of blood pressure and of heart rate.
Rioux
F
F
Nephrology-Pharmacology and Hypertension Unit, Centre de Recherche Hôtel-Dieu de Québec, Canada.
Lemieux
M
M
Kérouac
R
R
Bernoussi
A
A
Roy
G
G
D000287:Administration, Topical; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects*; D007082:Ileum / Q000187:drug effects / Q000502:physiology*; D007267:Injections; D007275:Injections, Intravenous; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D009496:Neurotensin / Q000008:administration & dosage / Q000494:pharmacology*; D010425:Pentolinium Tartrate / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012018:Reflex; D013270:Stomach / Q000187:drug effects / Q000502:physiology*
D009496:Neurotensin; D001285:Atropine; D010425:Pentolinium Tartrate; D008012:Lidocaine; D011433:Propranolol; D011224:Prazosin; D010646:Phentolamine