Effects of butorphanol tartrate on arterial pressure, jejunal blood flow, vascular resistance, O2 extraction, and O2 uptake in halothane-anesthetized ponies.
The effects of butorphanol tartrate on arterial pressure, jejunal blood flow, vascular resistance, oxygen extraction, and oxygen uptake were determined in 10 anesthetized ponies ventilated with a mixture of halothane and 100% oxygen, using isolated autoperfused jejunal segments. Physiologic saline solution or butorphanol tartrate (0.2 mg/kg of body weight) was administered as a single bolus into the left jugular vein. By 2 minutes, butorphanol decreased arterial blood pressure and intestinal blood flow, and increased intestinal oxygen extraction. However, intestinal vascular resistance and oxygen uptake were unaffected. Results of this study indicate that butorphanol tartrate induces a hypotension that secondarily decreases intestinal blood flow, but intestinal vascular resistance and metabolism are not adversely affected. We conclude that butorphanol tartrate does not compromise intestinal viability in halothane-anesthetized ponies and, therefore, may be a good analgesic choice for the equid destined for abdominal surgery.
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1101.
J A
JA
Stick
B S
BS
Loeffler
W A
WA
Arden
C C
CC
Chou
D000768:Anesthesia, General / Q000662:veterinary; D000818:Animals; D001783:Blood Flow Velocity / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects*; D002077:Butorphanol / Q000494:pharmacology*; D006221:Halothane; D006736:Horses / Q000502:physiology*; D007583:Jejunum / Q000098:blood supply*; D009019:Morphinans / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects*
D009019:Morphinans; D002077:Butorphanol; D006221:Halothane