The effects of calcium channel blocking drugs on the thermotropic behavior of dimyristoylphosphatidylcholine.
The effects of four calcium channel blocking drugs, diltiazem, verapamil, nimodipine and nisoldipine, on the main phase transition of dimyristoylphosphatidylcholine have been studied by high resolution differential scanning calorimetry. In all cases, the phase transition temperature is lowered, though much more effectively by nimodipine and nisoldipine than by the other two drugs. Nimodipine and nisoldipine markedly reduce the enthalpy of transition while diltiazem and verapamil have no significant effect on the enthalpy within the drug concentration range studied. Analysis of the data in terms of ideal solution theory is presented. X-ray and neutron scattering studies indicate that nimodipine and verapamil differ significantly with respect to their location within a lipid bilayer, and this difference suggests a partial rationalization of the experimental results presented here.
Department of Chemistry, Yale University, New Haven, CT 06511.
S J
SJ
Bae
S
S
Kitamura
L G
LG
Herbette
J M
JM
Sturtevant
D002121:Calcium Channel Blockers; D002152:Calorimetry, Differential Scanning; D004110:Diltiazem; D004134:Dimyristoylphosphatidylcholine; D008954:Models, Biological; D009543:Nifedipine / Q000031:analogs & derivatives; D009553:Nimodipine; D015737:Nisoldipine; D013816:Thermodynamics; D014700:Verapamil
D002121:Calcium Channel Blockers; D015737:Nisoldipine; D009553:Nimodipine; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine; D004134:Dimyristoylphosphatidylcholine