Fructose-related glycation.
We investigated in vitro the effect of the polyol pathway on the formation of advanced Maillard reaction products which have fluorescence and cross-links. Bovine serum albumin supplemented with various concentrations of glucose, fructose or sorbitol was incubated for 14 days. The fluorescence intensity was higher after incubation with fructose than after incubation with glucose. However, no significant increase in fluorescence intensity was found after incubation with sorbitol. These results suggest that in the polyol pathway fructose plays an important role in the formation of advanced Maillard products.
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
M
M
Oimomi
T
T
Nakamichi
T
T
Ohara
M
M
Sakai
N
N
Igaki
F
F
Hata
S
S
Baba
D005632:Fructose / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006031:Glycosylation; D015416:Maillard Reaction; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D013012:Sorbitol / Q000378:metabolism; D013050:Spectrometry, Fluorescence
D012710:Serum Albumin, Bovine; D005632:Fructose; D013012:Sorbitol; D005947:Glucose