Linkage between serum cholinesterase 2 (CHE2) and gamma-crystallin gene cluster (CRYG): assignment to chromosome 2.
Serum cholinesterase 2 (CHE2) was examined in a Danish material of normal families that has been tested earlier for 70-78 classical marker systems and 25 RFLP systems. DNA for RFLP typing was provided by transforming 16-year-old frozen lymphocytes. The frequency of allele CHE2*C5+ in the Danish population was found to be 0.0430. The highest lod score was between CHE2 and the gamma-crystallin gene cluster (CRYG) (zeta = 4.21 at theta = 0.00 in females). The scores were from a single family with 15 children. CHE2 may, accordingly, be assigned to the location of CRYG: chromosome 2, bands q33-q35.
University Institute of Medical Genetics, Copenhagen, Denmark.
H
H
Eiberg
L S
LS
Nielsen
J
J
Klausen
M
M
Dahlén
M
M
Kristensen
M L
ML
Bisgaard
N
N
Møller
J
J
Mohr
D001788:Blood Grouping and Crossmatching; D002802:Cholinesterases / Q000097:blood / Q000235:genetics*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D003459:Crystallins / Q000235:genetics*; D004589:Electrophoresis, Disc; D004912:Erythrocytes / Q000201:enzymology; D005190:Family; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D005810:Multigene Family
D003459:Crystallins; D002802:Cholinesterases