Effect of nicotinic acid supplementation in vivo on oxygen radical-induced genetic damage in human lymphocytes.
The ability of nicotinic acid to protect human lymphocytes in vivo against oxygen radical-induced DNA strand breakage was tested. NAD+ concentrations rose progressively in lymphocytes to nearly 5 times baseline levels in human volunteers ingesting nicotinic acid (100 mg/day) for 8 weeks. Strand breaks decreased proportionately to NAD+ concentrations over this time period in lymphocytes exposed to oxygen radicals. After 8 weeks of supplementation with nicotinic acid, radical-treated lymphocytes incubated for 24 h evidenced significantly less DNA damage compared to controls.
Division of Hematology/Oncology, Roger Williams Cancer Center, Providence, RI 02908.
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Weitberg
D004247:DNA / Q000187:drug effects / Q000378:metabolism; D004249:DNA Damage; D005609:Free Radicals; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D009243:NAD / Q000097:blood; D009525:Niacin / Q000008:administration & dosage / Q000494:pharmacology*; D010100:Oxygen / Q000633:toxicity*; D010779:Photofluorography
D005609:Free Radicals; D009243:NAD; D009525:Niacin; D004247:DNA; D010100:Oxygen