Effect of lead on the stromal cells of bone marrow in rats in vitro.
The effect of lead on the stromal cells of bone marrow in rats was studied in cultures in vitro. Toxic effects of lead were manifested by a decrease in erythrocyte count and hemoglobin level in peripheral blood. Lead stimulated an increase in the number of fibroblasts, while the macrophage count dropped. The number of adipocytes remained unaffected.
Miszta
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Department of Animal Physiology, Jagiellonian University, Cracow, Poland.
D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002453:Cell Cycle / Q000187:drug effects; D004906:Erythrocyte Count / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006454:Hemoglobins / Q000032:analysis; D066298:In Vitro Techniques; D007854:Lead / Q000633:toxicity*; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051381:Rats
D006454:Hemoglobins; D007854:Lead