[Hemodynamic effects of naloxone in early acute pancreatitis in the dog and its efficacy in treating acute pancreatitis].
Naloxone, an opiate receptor blocker, has been shown in earlier studies to have positive effect on cardiovascular function in a variety of diseases in which the secretion of endogenous opioid peptides was suspected. In this communication, a dog model of acute pancreatitis (AP) was made by intraductal injection of fresh trypsin-bile mixture, in which the hemodynamic changes were measured, the therapeutic efficacy of naloxone was evaluated. Pancreatitis was characterized by a fall in SAP, CO, dp/dt, an increase in PVR, SVR and the early reduction of pancreatic blood flow (QP). Administration of naloxone produced a significant increase in QP and led to normalization in SAP, CO, dp/dt, PVR and, SVR. In addition, Naloxone significantly reduced the severity and mortality of AP. These results suggest that naloxone appears to limit the progression from edematous to hemorrhagic pancreatitis through preserving QP at the early phase of AP. We propose the hypothesis that endogenous opiates may play a role in the pathophysiology of AP.
Shen
J
J
D000208:Acute Disease; D000818:Animals; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology* / Q000627:therapeutic use; D010179:Pancreas / Q000098:blood supply; D010195:Pancreatitis / Q000188:drug therapy / Q000503:physiopathology*
D009270:Naloxone