The protective effect of vagus nerve stimulation on catecholamine-halothane-induced ventricular fibrillation in dogs.
Parasympathetic neural activity modulates some ventricular arrhythmias in man. Therefore, a canine model of arrhythmias produced by the interaction of halothane and catecholamines was used to study the effects of vagal stimulation on the induction of ventricular fibrillation. The dose of catecholamine required to induce ventricular fibrillation was determined during a constant heart rate. Vagal stimulation reversibly raised the norepinephrine dose that produced ventricular fibrillation from 16.4 +/- 2.4 to 30.0 +/- 3.8 micrograms (p less than 0.001, n = 10), and the epinephrine dose from 15.5 +/- 2.0 to 22.5 +/- 2.6 micrograms (p less than 0.001, n = 5). Following atropine, vagal stimulation failed to raise the threshold dose of norepinephrine (16.8 +/- 2.4 vs. 18.3 +/- 3.3 micrograms, nonsignificant, n = 6) or epinephrine (15.5 +/- 2.0 vs. 16.0 +/- 2.3 micrograms, nonsignificant, n = 5). Ligation of the cervical vagus nerves did not affect the epinephrine threshold dose (16.3 +/- 3.3 vs. 17.5 +/- 2.7 micrograms, nonsignificant, n = 5). Following elevation of basal vagal tone by morphine premedication, the norepinephrine threshold of 53.0 +/- 9.2 micrograms declined by a nonsignificant amount to 46.5 +/- 11.5 micrograms after vagotomy (nonsignificant, n = 5). Thus resting vagal tone does not prevent catecholamine-halothane-induced ventricular fibrillation, whereas increasing vagal tone by electrical stimulation substantially protects against this arrhythmia. The protection is mediated through a muscarinic cholinergic receptor.
Department of Medicine, University of Toronto, Ont., Canada.
M B
MB
Waxman
A D
AD
Sharma
J
J
Asta
D A
DA
Cameron
R W
RW
Wald
D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D004558:Electric Stimulation; D004837:Epinephrine / Q000494:pharmacology*; D006221:Halothane / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D014630:Vagus Nerve / Q000502:physiology*; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000503:physiopathology*
D006221:Halothane; D009638:Norepinephrine; D004837:Epinephrine