Efficacy & dose-response of intrathecal pentazocine for post-operative pain relief.
With a view to assess the efficacy of intrathecal pentazocine for post-operative pain relief, 60 patients randomly divided into 6 equal groups were administered graded doses (0, 1, 2, 3, 4 and 5 mg respectively) of pentazocine lactate, intrathecally along with 1 per cent bupivacaine. The duration of analgesia was found to be dose related till 3 mg. Higher doses did not increase the duration of analgesia nor were any untoward effects observed. It is concluded that intrathecal pentazocine is safe and effective for post-operative pain relief and 3 mg is the minimum effective dose without side effect.
Chawla
R
R
Arora
M K
MK
Saksena
R
R
Gode
G R
GR
D000293:Adolescent; D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007278:Injections, Spinal; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D010423:Pentazocine / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
D010423:Pentazocine