[Initial experience with the administration of 7-methoxyacrine to patients with psychological disorders].
The cholinomimemtic substance 7-methoxyacrine was administered to eight patients, incl. 5 patients with tardive dyskinesias after neuroleptic drugs. In all patients an europhorizing effect was recorded, all five patients with tardive dyskinesias improved markedly after a single dose, in one female patient after repeated administration symptoms of tardive dyskinesia were eliminated. The incidence of side effects is minimal. Based on our modest experience we consider 7-methoxyacrine an important extension of therapeutic possibilities, in particular in tardive dyskinesias. The authors plan to test 7-methoxyacrine also in other indications, in particular in Alzheimer's disease and in side-effects caused by psychopharmaceutical preparations.
M
M
Zapletálek
H
H
Hanus
J
J
Fusek
V
V
Hrdina
D000328:Adult; D000609:Aminoacridines / Q000627:therapeutic use*; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013619:Tacrine / Q000031:analogs & derivatives / Q000627:therapeutic use*
D000609:Aminoacridines; D013619:Tacrine; C016222:7-methoxytacrine
První zkusenosti s podáním 7-metoxytakrinu psychicky nemocným.