A pneumotoxin, O,O,S-trimethyl phosphorothioate, induces hemorheological alteration in rats.
O,O,S-trimethyl phosphorothioate (OOS-TMP), an impurity present in widely used organophosphorus insecticides, has been shown to induce lung injury after oral administration. To date, very little is known about the hemorheological changes which may occur during the inflammation of lung caused by OOS-TMP. The present study has demonstrated that oral administration of OOS-TMP (10 mg/kg, 20 mg/kg) to rats produced an increase in whole blood apparent viscosity at 24, 48 and 72 h following the treatment in rats. Concomitantly, the plasma fibrinogen level and red blood cell (RBC) aggregation were increased at 24 and 48 h. There was no change in RBC filterability. Thus, OOS-TMP, a pneumotoxin, was capable of causing a systemic hemorheological alteration, probably via increase in fibrinogen content, an acute-phase protein, in rats.
Unit of Experimental Pharmacology and Biochemistry, Zyma SA, Nyon, Switzerland.
M L
ML
Bezençon
S K
SK
Durham
J
J
Roux
E M
EM
Grandjean
T
T
Imamura
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects*; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D004907:Erythrocyte Deformability / Q000187:drug effects*; D005340:Fibrinogen / Q000032:analysis; D006400:Hematocrit; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008171:Lung Diseases / Q000097:blood / Q000139:chemically induced; D008297:Male; D063086:Organothiophosphates / Q000633:toxicity*; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D011014:Pneumonia / Q000097:blood / Q000139:chemically induced; D051381:Rats
D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; C019123:O,O,S-trimethyl phosphorothioate; D005340:Fibrinogen; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase