Bilateral testicular and adrenal malignant lymphoma of pre B-cell type.
A rare case of pre B-lymphoblastic lymphoma of the testes and adrenal glands is presented. No lymph node, central nervous system or bone marrow involvement was demonstrated at diagnosis. The primary presentation was of acute unilateral pain and swelling, mimicking simple orchitis. The diagnosis was made using aspiration cytology and the lymphoma characterized using immunohistochemical, electron microscopic and karyotype analysis techniques. Pre B-cell markers were clearly demonstrated by all criteria used. Monoclonal antibodies (FMC 29 and FMC 31) were used to define the early B-cell nature of the lymphoma. Confirmation using karyotype analysis in addition to immunoglobulin and T-cell beta-receptor gene rearrangement was obtained. Intrathecal chemotherapy was used prophylactically. Combination chemotherapy produced regression of the primary lymphomatous lesions, but subsequent bone marrow spread led to death.
Department of Surgery, Flinders Medical Centre, Adelaide, South Australia.
B J
BJ
Coventry
J N
JN
Nacey
S
S
Orell
V R
VR
Marshall
R
R
Seshadri
D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D001402:B-Lymphocytes; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D013736:Testicular Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology