[Effect of various contrast media on platelet aggregation--an in vivo study].
Recently, some radiologists using non-ionic contrast media for angiography have noted the increased tendency of thrombus formation in the injection syringe or angiographic catheter contaminated with blood. In vitro studies by some authors have shown that non-ionic contrast media had only a slight anticoagulative effect as compared with ionic contrast media. But the in vivo studies comparing the anticoagulative effect of both ionic and non-ionic contrast media have not been performed previously. We investigated the effect of non-ionic and ionic contrast media on platelet aggregation in 40 patients undergoing angiography. The in vivo study revealed a negligible influence of both non-ionic and ionic contrast media on systemic platelet aggregation. The dose of contrast media also showed no significant correlation with platelet aggregation. Our study suggests that the data from in vitro experiments cannot be extended to in vivo study as for the relationship between contrast media and their anticoagulant effect.
Shinmoto
H
H
Ido
K
K
Yuasa
Y
Y
Endo
M
M
Yasuoka
H
H
Edamitsu
S
S
Takahashi
K
K
Koizumi
J
J
Hiramatsu
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000009:adverse effects*; D003973:Diatrizoate / Q000009:adverse effects; D006801:Humans; D007472:Iohexol / Q000009:adverse effects; D007479:Iopamidol / Q000009:adverse effects; D007485:Ioxaglic Acid / Q000009:adverse effects; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*
D003287:Contrast Media; D003973:Diatrizoate; D007472:Iohexol; D007479:Iopamidol; D007485:Ioxaglic Acid