Developing rat cerebellum--III. Effects of abnormal thyroid states and undernutrition on gangliosides.
Alteration of rat postnatal cerebellar development produced by undernutrition, thyroxine treatment and thyroid deficiency also involves ganglioside deposition. The distribution of the different ganglioside types is apparently unaffected but quantitative alterations are present that reflect the reduction of cell number and cell process surface in the adult, and either acceleration or slowing down or reduction of cell formation and maturation occurring during cerebellar development in the three experimental situations.
Vitiello
F
F
Istituto di Fisiologia Umana, Facoltà di Medicina e Chirurgia, Bari, Italy.
Clos
J
J
Di Benedetta
C
C
Gombos
G
G
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000254:growth & development* / Q000378:metabolism; D005732:Gangliosides / Q000378:metabolism*; D007037:Hypothyroidism / Q000378:metabolism*; D009748:Nutrition Disorders / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000494:pharmacology / Q000502:physiology*
D005732:Gangliosides; D013974:Thyroxine