Two stage carcinogenesis by membrane potential changes.
The membrane potential theory is modified and extended. It is shown to be applicable to carcinogenesis by prolonged treatment of target tissues with an initiating external carcinogen or by a single sub-threshold exposure to the initiating external carcinogen followed by subsequent treatment with a phorbol ester internal promoter.
Beech
J A
JA
D000818:Animals; D002273:Carcinogens; D003043:Cocarcinogenesis; D008564:Membrane Potentials; D008954:Models, Biological
D002273:Carcinogens