[Primary malignant melanoma of ORL mucosa. Apropos of 5 cases].
Based on five observations of primary mucosal melanomas recently treated in the department, the authors describe the main features of this very rare condition, and particularly the evolutive aspects in diagnosis and prognosis. Histological diagnosis is sometimes difficult, and must involve specific argentic staining and a search for the presence of the protein S100. Tumor thickness was systematically examined. No prognostic interpretation, however, is possible, given the small number of cases in the series. Evolution is unpredictable; there is very commonly a series of local recurrences which may be well controlled, followed by remote metastases remaining long quiescent, bypassing the cervical ganglion relay. Treatment is surgical whenever possible, with palliative radiotherapy for local recurrences and chemotherapy for metastatic forms. Other therapies have yet to prove their effectiveness.
D
D
Stoll
P
P
Boudard
C
C
Deminière
D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D008875:Middle Aged; D009297:Nasal Mucosa; D009364:Neoplasm Recurrence, Local; D009669:Nose Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy
Mélanome malin primitif des muqueuses O.R.L. Etude à propos de 5 cas.