The effect of high cholesterol, high fat diet on rabbit plasma beta-VLDL and its interaction with macrophage.
Rabbits were fed on 1% cholesterol and 10% rape seed oil (group A) or lard (group B). Plasma cholesterol and triglyceride level of group A was strikingly lower than that of group B. No difference was found in the lipid composition of beta-VLDLs between both groups. However, apo E content of beta-VLDL from group A was higher and apo B (higher molecular weight) was lower than that of group B respectively. beta-VLDL of group A caused greater accumulation of cholesterol in mouse peritoneal macrophage than that of group B. Therefore, we assume that the good effect of poly-unsaturated fatty acid on atherosclerosis results not from decreasing accumulation of cholesterol in macrophages but from enhancing elimination of beta-VLDL by the liver.
Wang
S P
SP
Feng
Z C
ZC
Feng
Y M
YM
Wu
W S
WS
Wang
C B
CB
Jiang
W G
WG
Dai
W X
WX
Liang
J G
JG
D000818:Animals; D001057:Apolipoproteins E / Q000097:blood; D004036:Diet, Atherogenic; D005231:Fatty Acids, Unsaturated; D008079:Lipoproteins, VLDL / Q000097:blood*; D008264:Macrophages / Q000378:metabolism*; D010529:Peritoneal Cavity / Q000166:cytology; D011817:Rabbits
D001057:Apolipoproteins E; D005231:Fatty Acids, Unsaturated; D008079:Lipoproteins, VLDL