[Tree pollens and nasal allergy (XI). Relationship of age to the total IgE level, Japanese cedar RAST score, Japanese cedar-specific IgG antibodies and IgG subclass].
Japanese cedar pollinosis occurs most frequently in the twenties and thirties. To understand this phenomenon, total serum IgE, frequency of positive RAST reactions to Japanese cedar and Japanese cedar-specific IgG antibody were examined in serum samples from a general population consisted of 1,491 subjects and their age-related changes were investigated. The difference of mean value of total serum IgE was not significant between age groups. Positive RAST's to Japanese cedar were found in 13.9% of cases. The frequency of positive RAST reactions showed a peak in the twenties and decreased thereafter with aging. The amount of Japanese cedar-specific IgG antibodies was 244.7 +/- 373.2 GRU/ml (mean +/- S.D.) and there was no significant difference between males and females. There was no difference in the amount of specific IgG antibodies among the subjects giving RAST scores of 0-3, whereas those giving RAST scores of 4 had lower specific IgG antibodies. The amount of Japanese cedar-specific IgG antibodies increased from the fifties. Specific antibody of IgG1 subclass to Japanese cedar increased with age, whereas IgG4 antibody increased slightly without statistically significant difference. Based on the above result, we discussed why Japanese cedar pollinosis occurs most frequently in the twenties and thirties.
Enomoto
T
T
Yokoyama
M
M
Nakanishi
H
H
Samukawa
T
T
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000906:Antibodies / Q000032:analysis*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis* / Q000145:classification; D008875:Middle Aged; D011058:Pollen / Q000276:immunology*; D011852:Radioallergosorbent Test
D000906:Antibodies; D007074:Immunoglobulin G; D007073:Immunoglobulin E