[Value of determining the activity of cholesterol esterase in the duodenal contents].
Cholesterol esterase, a pancreatic enzyme, activity has been measured in the duodenal contents of patients with chronic pancreatitis by fluorometry with the use of o-coumaric acid, a cholesteryl ether substrate, manufactured in this country. The measurements have revealed a significant difference in the values of the enzyme secretion debit after pancreozymin-secretin stimulation of the pancreas in chronic pancreatitis patients and in the controls. Hypo- and hypersecretion of cholesterolesterase have been revealed in the patients. The disease severity had a most marked effect on the hyposecretion degree. These data evidence a high value of cholesterolesterase measurements for the assessment of the pancreatic exosecretion: such tests may help detect the early stages of exosecretory disturbances, assess the disease severity and progress.
A S
AS
Loginov
L O
LO
Shibaeva
V M
VM
Sadokov
Z S
ZS
Isakova
D000328:Adult; D002265:Carboxylic Ester Hydrolases / Q000032:analysis*; D002908:Chronic Disease; D004386:Duodenum / Q000201:enzymology*; D005766:Gastrointestinal Contents / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D010186:Pancreatic Function Tests; D010195:Pancreatitis / Q000175:diagnosis* / Q000201:enzymology; D002787:Sterol Esterase / Q000032:analysis*
D002265:Carboxylic Ester Hydrolases; D002787:Sterol Esterase
Znachenie opredeleniia aktivnosti kholesterolésterazy v duodena'lnom soderzhimom.