The effect of moderate fluosol-DA hemodilution on gender specific metabolism of antipyrine.
Antipyrine metabolism was determined after hemodilution with 40 ml/kg of Fluosol in conscious, unrestrained female and male rats. Rats received an intravenous antipyrine dose (20 mg/kg) 24, 48, or 72 hours after hemodilution and the pharmacokinetic parameters were compared to non-exchanged control animals. Changes in the plasma disposition parameters were the same in both genders but the specific characteristic of a greater half-life in female rats was retained. A significant increase in antipyrine clearance was found at 48 hours after hemodilution. 3OHME clearance was increased in both female and male rats but 4OH clearance was increased only in female rats at that time. The data also suggested that the Fluosol emulsion induced a different microsomal enzyme activity change than its most studied component, perfluorodecalin.
Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360.
R P
RP
Shrewsbury
L G
LG
White
D000818:Animals; D000983:Antipyrine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism* / Q000493:pharmacokinetics / Q000652:urine; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D005466:Fluorocarbons / Q000494:pharmacology*; D006207:Half-Life; D006438:Hemodilution; D006895:Hydroxyethyl Starch Derivatives; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C060936:3-methylantipyrine; C007983:4-hydroxyantipyrine; C031820:3-hydroxymethylantipyrine; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D000983:Antipyrine