[Macro-creatine kinase: not all increased CK-MB activity signifies a heart infarct].
Assay of creatine kinase MB isoenzyme plays an important role in the diagnosis of acute myocardial infarction. An increase in CK-MB is frequently interpreted by the clinician as objective evidence of myocardial cell damage. However, increases of CK-MB may be found in several circumstances in which patients have not sustained an acute myocardial infarction. An important cause of elevated CK-MB values unrelated to acute MI is the presence of macro-creatine kinases in the patient's plasma. With immuno-inhibition procedures macro-CK is often measured as CK-MB, leading to falsely elevated CK-MB. In this paper macro-CKs, their clinical importance and their interference with CK-MB determination are discussed.
L J
LJ
Reichert
F
F
van der Graaf
P G
PG
Gerlag
D000368:Aged; D003402:Creatine Kinase / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D005756:Gastritis / Q000201:enzymology*; D006801:Humans; D007527:Isoenzymes; D046911:Macromolecular Substances; D008875:Middle Aged; D008970:Molecular Weight; D009203:Myocardial Infarction / Q000201:enzymology; D009362:Neoplasm Metastasis / Q000201:enzymology*
D007527:Isoenzymes; D046911:Macromolecular Substances; D003402:Creatine Kinase
Macro-creatine-kinase: niet iedere verhoogde CK-MB-activiteit duidt op een hartinfarct.