Fluctuation of the number of CD-1(T6)-positive dendritic cells, presumably Langerhans cells, in the nasal mucosa of patients with an isolated grass-pollen allergy before, during, and after the grass-pollen season.
A monoclonal antibody against CD-1(T6) was used for studies in the nasal mucosa of patients with isolated grass-pollen allergy to determine whether the number of CD-1-positive cells, presumably Langerhans cells, depends on the season in which the nasal biopsy is performed. An earlier study had demonstrated that during the grass-pollen season, there are significantly more CD-1-positive cells in nasal mucosa of patients with isolated grass-pollen allergy than in nonallergic control subjects without nasal complaints. During the grass-pollen season, the nasal epithelium of patients with an isolated grass-pollen allergy demonstrated significantly more CD-1-positive cells than before and after the season. Before and after the season, the number of CD-1-positive cells in epithelium of the allergic patients was not significantly greater than the corresponding number in epithelium of nonallergic subjects without nasal complaints.
Department of Otorhinolaryngology, University Hospital, Rotterdam.
W J
WJ
Fokkens
T M
TM
Vroom
E
E
Rijntjes
P G
PG
Mulder
D000293:Adolescent; D000328:Adult; D002452:Cell Count; D005260:Female; D006801:Humans; D007801:Langerhans Cells / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000166:cytology*; D006109:Poaceae; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000473:pathology*; D013997:Time Factors