Urinary lactic dehydrogenase isoenzyme analysis in children with spinal lesions.
In 48 children with spinal lesions and micturition problems urinary lactic dehydrogenase (LDH) isoenzymes were analyzed. They had higher total LDH activities (716.8 +/- 1,050.2 nkat/I), isoenzymes V percents (22.2 +/- 13.0%) and isoenzyme V activities (203.4 +/- 308.4 nkat/I) than those of healthy children (150.0 +/- 83.4 nkat/I, 1.9 +/- 1.0%, 5.0 +/- 3.3 nkat/I). Many subjects had an isoenzyme V-dominant LDH isoenzyme pattern. Among 48 subjects the patients with pyuria, bacteriuria or abnormal pyelograms had markedly high total LDH activities, isoenzyme V percents and isoenzyme V activities. The rise in LDH isoenzyme V levels may reflect the renal damage in the patients with neurogenic bladders.
Department of Pediatrics, Seirei-Mikatabara General Hospital, Hamamatsu, Japan.
K
K
Yokochi
T
T
Uchida
K
K
Kodama
D000293:Adolescent; D001437:Bacteriuria; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000652:urine*; D008297:Male; D013122:Spinal Diseases / Q000150:complications / Q000201:enzymology*; D013124:Spinal Injuries / Q000150:complications / Q000201:enzymology*; D014555:Urination Disorders / Q000150:complications / Q000201:enzymology
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase