Levels of protein kinase C activity in human gastrointestinal cancers.
The protein kinase C (PKC) activities of tumor tissue and adjacent normal mucosa of human cancers of the esophagus (8 cases), stomach (1 case) and colon (3 cases) were measured. Considerable variations were found in the activity of PKC and in its subcellular distribution in these cancers. The PKC activities of the membrane and cytosolic fractions of the eight esophageal cancers were, however, similar to those of the adjacent normal mucosa: the average PKC activities of the tumor tissues and normal mucosa were 7.5 and 8.3 pmol/min/mg protein, respectively, in their membrane fractions and 7.9 and 7.8 pmol/min/mg protein, respectively, in their cytosolic fractions.
Department of Cancer Cell Research, University of Tokyo, Japan.
Y
Y
Hashimoto
K
K
Chida
M
M
Huang
M
M
Katayama
T
T
Nishihira
T
T
Kuroki
D002462:Cell Membrane / Q000201:enzymology; D003110:Colonic Neoplasms / Q000201:enzymology; D003600:Cytosol / Q000201:enzymology; D004938:Esophageal Neoplasms / Q000201:enzymology; D005770:Gastrointestinal Neoplasms / Q000201:enzymology*; D006801:Humans; D009092:Mucous Membrane / Q000201:enzymology; D011493:Protein Kinase C / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000201:enzymology
D011493:Protein Kinase C