Transient exacerbation of tics in treatment of Tourette's syndrome with clonidine.
An 11-year-old boy with a history of behavioral problems was admitted to the inpatient Child Development Program of St. Louis University Medical Center. A diagnosis of Tourette's syndrome was made, and when family objected to a trial of haloperidol for fear of tardive dyskinesia, clonidine was initiated. A temporary period of worsening of motor and phonic tics ensued, while dose adjustments were made. When a maintenance level was achieved, approximately 2 weeks after initiating treatment, remission of symptoms was observed.
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D002648:Child; D003000:Clonidine / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D005879:Tourette Syndrome / Q000139:chemically induced* / Q000188:drug therapy
D003000:Clonidine