Blood pressure and impairment of endothelium-dependent relaxation in spontaneously hypertensive rats.
Correlation between hypertension and impairment of endothelium-dependent relaxation was demonstrated using aortae from certain strains of rats with various levels of spontaneous hypertension. It was also observed that the impairment of endothelium-dependent relaxation is the secondary change due to hypertension, and the level and duration of hypertension is the determinant factor of the impairment.
Sunano
S
S
Research Institute of Hypertension, Kinki University, Osaka, Japan.
Osugi
S
S
Shimamura
K
K
D000818:Animals; D001011:Aorta / Q000503:physiopathology*; D001794:Blood Pressure; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006973:Hypertension / Q000503:physiopathology*; D009126:Muscle Relaxation; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY