Erythro-lectin immuno test (Erythro-LIT) in the immunodiagnosis of neurocysticercosis.
1. The effectiveness of the Erythro-Lectin Immuno Test (Erythro-LIT) to detect anticysticercus antibodies was tested using cerebrospinal fluid (CFS) from patients with neurocysticercosis. 2. Both Erythro-LIT and complement fixation (CF) were used to detect antibodies in 36 CSF samples from cysticercotic patients. Erythro-LIT detected anticysticercus antibodies in 35 CSF samples (97%) and CF in 26 (72%). The antibody titers ranged from 1:4 to 1:4096 for Erythro-LIT (mean geometric titer = 282.65) and 1:1 to 1:64 in CF (mean geometric titer = 7.92). 3. When greater than or equal to 1:16 Erythro-LIT titer was used as a significant diagnostic cut-off value, the sensitivity and specificity of Erythro-LIT were 92% and 100%, respectively, for CFS. 4. The high sensitivity and specificity demonstrated here, together with the simplicity and low cost of the test, make the Erythro-LIT a potentially useful method for screening for specific antibodies in neurocysticercosis.
Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Brasil.
C L
CL
Rossi
L S
LS
Prigenzi
J A
JA
Livramento
D000818:Animals; D000909:Antibodies, Helminth / Q000134:cerebrospinal fluid*; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid*; D003551:Cysticercosis / Q000134:cerebrospinal fluid*; D003552:Cysticercus / Q000276:immunology*; D006801:Humans; D007159:Immunologic Tests / Q000379:methods*; D013621:Taenia / Q000276:immunology*
D000909:Antibodies, Helminth