[The effect of subtherapeutic quantities of native gelatin and Haemaccel 35 (polygeline) on the fibronectin level and wound healing. An experimental animal study in rats with burn wounds].
Posttraumatically, opsonic plasma fibronectin is consumed by collagen-like degradation products that enter the vascular system. Additional administration of gelatin (= denatured collagen) results in an essential lack of fibronectin with subsequent retardation of wound healing even when subtherapeutic amounts are given. Therefore, in an experiment with rats we studied the question of whether similar effects are evoked by equal amounts of Haemaccel 35 (cross-linked polypeptides from degraded gelatin). The animals received standardized third degree burn injuries of about 1% of body surface. Immediately after wounding and on the following 2 days native gelatin or Haemaccel was applied intraperitoneally in 2 different dosages (61 mg/kg and 122 mg/kg). The burn injury by itself did not cause a significant decrease of plasma fibronectin. After injection of gelatin a dramatic deprivation of plasma fibronectin occurred and, in consequence, a delay of the healing process. After administration of equal amounts of Haemaccel 35, however, there was neither a depletion of plasma fibronectin nor any significant effect on wound healing.
Nagelschmidt
M
M
II. Chirurgischer Lehrstuhl der Universität zu Köln.
Röddecker
K
K
Weiser
M
M
D000818:Animals; D002056:Burns / Q000503:physiopathology*; D005353:Fibronectins / Q000097:blood*; D005780:Gelatin / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D011097:Polygeline / Q000008:administration & dosage / Q000494:pharmacology*; D011108:Polymers / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing / Q000187:drug effects*
D005353:Fibronectins; D011108:Polymers; D005780:Gelatin; D011097:Polygeline
Einfluss subtherapeutischer Mengen nativer Gelatine und Haemaccel 35 (Polygeline) auf den Fibronektinspiegel und die Wundheilung. Eine tierexperimentelle Studie an Ratten mit Brandwunden.