Side-effect evaluation of a new diazepam formulation: venous sequela reduction following intravenous (i.v.) injection of a diazepam emulsion in rabbits.
Diazepam has been incorporated into a stable, submicronized injectable emulsion. Venous sequela induction in rabbits following iv administration of diazepam in a marketed hydroalcoholic solution and in the emulsion were determined and compared over a 5-day period. There was a marked difference in the local reactions induced by the iv administration of the marketed diazepam hydroalcoholic solution and the diazepam emulsion, even on the first postinjection day. This difference was confirmed by pathological analysis. The highest mean venous sequela score was reached by the rabbit group injected with the marketed diazepam solution. It should be noted that no statistical difference was observed between the saline and the diazepam emulsion rabbit groups during the 5 days of the observation period. The moderate increase in the venous sequela score values compared to that for the saline solution should be attributed to the intrinsic effect produced by diazepam itself, and not to the emulsion vehicle, which was shown not to induce any vascular reaction in the present study.
Department of Pharmacy, School of Pharmacy, Hebrew University of Jerusalem, Israel.
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MY
Levy
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L
Langerman
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Gottschalk-Sabag
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S
Benita
D000818:Animals; D001808:Blood Vessels / Q000033:anatomy & histology; D002626:Chemistry, Pharmaceutical; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D004355:Drug Stability; D004655:Emulsions; D007275:Injections, Intravenous; D010316:Particle Size; D011817:Rabbits; D013696:Temperature
D004655:Emulsions; D003975:Diazepam