Prevention of rat fissure caries by sodium fluoride varnish (Duraphat) with different fluoride concentrations.
125 Osborne-Mendel rats were weaned at 22-23 days, inoculated with Streptococcus sobrinus and fed a cariogenic diet for 40 days. The control group received no treatment; the study groups received applications of Duraphat containing 2.3, 1.1, or 0.6% fluoride or a placebo varnish on days 21-23. The placebo varnish had no effect on caries. Fissure caries was significantly reduced by the 2.3 and 1.1% fluoride varnishes, whereas the caries reduction found after treatment with the 0.6% fluoride varnish was not statistically significant. These results suggest that reducing the fluoride content of Duraphat by half does not significantly reduce its caries-preventive effect, but the progress of caries seems to be somewhat slower with the 2.3% fluoride varnish.
Faculty of Dentistry, University of Kuopio, Finland.
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Seppä
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Forss
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Sormunen
D000818:Animals; D003731:Dental Caries / Q000517:prevention & control*; D003750:Dental Fissures / Q000517:prevention & control*; D004037:Diet, Cariogenic; D004305:Dose-Response Relationship, Drug; D005260:Female; D005460:Fluorides, Topical / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D012969:Sodium Fluoride / Q000008:administration & dosage*; D013295:Streptococcus mutans / Q000302:isolation & purification
D005460:Fluorides, Topical; C023807:sodium fluoride topical preparation; D012969:Sodium Fluoride