A case of IgA nephropathy associated with vitiligo, primary hypothyroidism and primary adrenocortical insufficiency.
A 14 year old boy presented with recurrent attacks of macroscopic haematuria preceded by tonsillitis. Clinical examination revealed generalised vitiligo. Renal function was normal with microscopic haematuria. Percutaneous renal biopsy showed mesangial proliferation on light microscopy with deposition of IgA and IgM in a granular pattern in the mesangium and glomerular basement membrane compatible with a diagnosis of IgA nephropathy. Biochemical investigations revealed primary hypothyroidism and primary adrenocortical insufficiency with negative organ specific autoimmune screen. Renal function has not deteriorated after three years follow-up. This particular association has not been previously described to our knowledge.
Madden
B P
BP
Walker
F
F
Gaffney
E
E
Keogh
J A
JA
D000293:Adolescent; D000309:Adrenal Insufficiency / Q000150:complications*; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D007037:Hypothyroidism / Q000150:complications*; D008297:Male; D014820:Vitiligo / Q000150:complications* / Q000276:immunology