Sequential changes of IgG and antitrypsin in different compartments during the colostral-intestinal transfusion of immunity to the newborn foal.
IgG levels and tryptic inhibition were investigated in sequentially collected mare's colostrum and milk, foal serum and urine. The colostral trypsin-inhibitor was "transfused" to the newborn foal by the colostral intestinal route in parallel with IgG. However, the trypsin-inhibitor as a small molecular weight inhibitor became excreted into urine peaking at about 20 hours. The physiological proteinuria in foals during the first 2 days is mostly due to immunoglobulin fragments and colostral-derived trypsin-inhibitor. Analysis of urine for IgG light chains or trypsin inhibitor will therefore reveal ingestion of colostrum.
Saikku
A
A
Koskinen
E
E
Sandholm
M
M
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D003126:Colostrum / Q000276:immunology*; D005260:Female; D006736:Horses / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis*; D011247:Pregnancy; D014361:Trypsin Inhibitors / Q000032:analysis*
D007074:Immunoglobulin G; D014361:Trypsin Inhibitors