Automated method for measuring fighting behavior and locomotor activity of mice.
A multiunit apparatus for automatic quantification of intermale fighting behavior and locomotor activity of mice is described. The method uses static charge sensitive beds (SCSB) to detect movement, and appropriate hard- and software for data acquisition and analysis. The data obtained with the SCSB-method correlated well with those observed from video-recordings of the same 60 aggression trials for determining both the total fighting times (r = .967) and the latencies to first fighting (r = .982). d-Amphetamine significantly increased locomotor activity counts on the SCSBs, and this increase was blocked by haloperidol. It is concluded, that the SCSB-method is an accurate and flexible technique for quantifying intermale fighting behavior and locomotor activity of mice.
Research Laboratories, Alko Ltd., Helsinki, Finland.
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D000374:Aggression; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003625:Data Collection / Q000295:instrumentation*; D003913:Dextroamphetamine / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects
D006220:Haloperidol; D003913:Dextroamphetamine