[Insulin resistance in experimental hypo- and hyperthyroidism].
The effect of thyroid hormones on the realization of body insulin function was investigated on the models of hypo- and hyperthyroidism. Hyperthyroidism resulting from thyroidectomy, caused the development of insulin resistance, expressed in a lowered body reaction to i. v. insulin infusion, a decrease in tissue sensitivity and reactivity to insulin. Insulin resistance in hypothyroidism was accountable for by a decrease in the serum total activity of insulin-like growth factors. Insulin resistance in hyperthyroidism was less notable and observed only in 10-day administration of thyroiodine; more prolonged administration of the drug (up to 30 days) restored insulin sensitivity. This effect can be accounted for by enhanced insulin independent glucose consumption caused by thyroid hormones.
Kosovskiĭ
M I
MI
Katkova
S P
SP
Mirakhmedov
M M
MM
Rakhimdzhanov
R T
RT
D000273:Adipose Tissue / Q000502:physiology; D000818:Animals; D004837:Epinephrine / Q000502:physiology; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology; D005951:Glucose Tolerance Test; D006980:Hyperthyroidism / Q000503:physiopathology*; D007037:Hypothyroidism / Q000503:physiopathology*; D007262:Infusions, Intravenous; D007333:Insulin Resistance; D008066:Lipolysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy
D005947:Glucose; D004837:Epinephrine
Insulinorezistentnost' pri éksperimental'nom gipo- i gipertireoze.