[Radiation stimulation of the production of thymocyte growth factor and its possible role in thymus recovery].
Cells of two lines originating from intrathymic precursors of mouse T-lymphocytes produce an autocrine growth factor. The factor production during a certain period of the development of lines is drastically increased by radiation. The stimulatory effect of radiation cannot be explained by the release of the factor due to cell death. The administration of cultural supernatants, containing thymocyte growth factor, to the exposed mice favours the recovery of the thymus at early times following irradiation and influences the thymocyte response to the effect of growth factors.
E A
EA
Protsak
V P
VP
Shichkin
A A
AA
Iarilin
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D005260:Female; D006133:Growth Substances / Q000494:pharmacology / Q000502:physiology / Q000528:radiation effects*; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010455:Peptides / Q000494:pharmacology / Q000502:physiology / Q000528:radiation effects*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013268:Stimulation, Chemical; D013950:Thymus Gland / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*
D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D010835:Phytohemagglutinins; C052275:thymocyte growth peptide
Stimuliatsiia oblucheniem vyrabotki faktora rosta timotsitov i ego vozmozhnaia rol' v vosstanovlenii timusa.