Baclofen antagonism by 4-amino-3-(5-methoxybenzo[b]furan-2-yl) butanoic acid in the cat spinal cord.
When administered microelectrophoretically, 4-amino-3-(5-methoxybenzo[b]furan-2-yl)butanoic acid (MBFG) reversibly reduced the presynaptic depression by (-)-baclofen of the monosynaptic excitation of spinal interneurones by impulses in muscle low-threshold afferent fibres of the cat as well as the postsynaptic depression by (-)-baclofen of the firing of these neurones. MBFG, as an antagonist of (-)-baclofen, may be useful in investigating the structure-activity relationships of central and peripheral baclofen receptors.
Beattie
D T
DT
Division of Neuroscience, John Curtin School of Medical Research, Canberra, A.C.T., Australia.
Curtis
D R
DR
Debaert
M
M
Vaccher
C
C
Berthelot
P
P
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001572:Benzofurans / Q000494:pharmacology*; D002415:Cats; D004558:Electric Stimulation; D007395:Interneurons / Q000187:drug effects / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology; D012023:Reflex, Monosynaptic / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D001572:Benzofurans; C060686:4-amino-3-(5-methoxybenzo(b)furan-2-yl)butanoic acid; D005680:gamma-Aminobutyric Acid; D001418:Baclofen