[Comparative studies of diatrizoate, ioxaglate and iohexol as angiocardiographic contrast media].
We did 2 consecutive randomized studies to compare the effects of diatrizoate, ioxaglate, and iohexol. Sixty patients were studied: 15 with diatrizoate (group I) versus 15 with ioxaglate (IIA), and 15 with ioxaglate (IIB) versus 15 with iohexol (III). Group I had hypotension and severe increase in end-diastolic pressure. Severe bradycardia was seen in 27% of the cases. Group IIA and IIB had identical changes, with a moderate increase in systolic and end-diastolic pressure. Group III only presented a mild increase in end-diastolic pressure. None of the low-osmolar contrast media produced severe bradycardia, but ioxaglate induced frequent (20%) nausea. Our results suggest the best contrast media for angiocardiography is, in decreasing order: iohexol, ioxaglate, and diatrizoate.
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Esplugas
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Torrents
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Mauri
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Jara
D000790:Angiocardiography; D001919:Bradycardia / Q000139:chemically induced; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D003973:Diatrizoate / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007472:Iohexol / Q000009:adverse effects*; D007485:Ioxaglic Acid / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation
D003973:Diatrizoate; D007472:Iohexol; D007485:Ioxaglic Acid
Estudios comparativos entre diatrizoato, ioxaglato e iohexol como contraste cardioangiográfico.