The effect of diclofenac sodium on renal function.
The effects of diclofenac sodium on the kidneys were studied during 4 1/2 hours in eight patients with normal renal function. Urinary output decreased within 10 min after the injection, and maximally by 80%. The renal plasma flow and the glomerular filtration rate initially diminished significantly, by 35%, but began to increase after only 2 hours. The dominant and persistent effect was reduction of free water clearance, with maximum fall from 5.9 to 0.08 ml/min after 2 1/2 hours. The long-lasting increased tubular reabsorption of water probably is important for the lowered intrapelvic pressure that is associated with good analgetic effect of diclofenac in ureteral colic.
Department of Urology, Karolinska Hospital, Stockholm, Sweden.
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AC
Kinn
J
J
Elbarouni
P
P
Seideman
A
A
Sollevi
D000328:Adult; D003085:Colic / Q000188:drug therapy; D004008:Diclofenac / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation / Q000187:drug effects; D013997:Time Factors; D014515:Ureteral Diseases / Q000188:drug therapy
D004008:Diclofenac