Anti-HIV drugs: comparative toxicities in murine fetal liver and bone marrow erythroid progenitor cells.
The toxicity of anti-HIV drugs, 3'-azido-3'-deoxythymidine (zidovudine, AZT), 2',3'-dideoxycytidine (DDC), 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) and ribavirin was studied in vitro in murine fetal liver cells (FLC) and in bone marrow cells. These studies indicate that d4T is the least toxic drug and ribavirin is the most toxic agent in both models. However, the murine FLC system was found to be a more sensitive model for the assessment of toxicity of anti-HIV agents towards erythroid progenitor cells as indicated by the IC50 values.
Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112.
S R
SR
Gogu
B S
BS
Beckman
K C
KC
Agrawal
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D015224:Dideoxynucleosides / Q000633:toxicity; D005333:Fetus; D006678:HIV / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects*; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D012254:Ribavirin / Q000633:toxicity; D016047:Zalcitabine / Q000031:analogs & derivatives*; D015215:Zidovudine / Q000633:toxicity
D000998:Antiviral Agents; D015224:Dideoxynucleosides; C019336:2',3'-dideoxythymidine; D012254:Ribavirin; D015215:Zidovudine; D016047:Zalcitabine; C050624:2',3'-dideoxycytidinene