[The distribution, characteristics and effects of ir-BNP in central and peripheral tissues in rat].
The present study first investigated the distribution, biochemical characteristics, receptor binding and biological effects of immunoreactive brain natriuretic peptide (ir-BNP), in the central nervous system and some peripheral tissues in rats, using highly specific radioimmunoassay, radioreceptor assay and immunohistochemical method. The results suggest that BNP may be a novel neurotransmitter or circulatory hormone, which is widely distributed in various tissues and involved in the regulation of water electrolyte balance and cardiovascular activity.
Tang
J A
JA
Cui
H
H
Xu
D
D
Li
C Y
CY
Wang
J P
JP
Meng
Z H
ZH
Peng
J Y
JY
Yuan
Q X
QX
Zhang
D
D
Zhang
Z K
ZK
D000818:Animals; D002490:Central Nervous System / Q000032:analysis; D007150:Immunohistochemistry; D008297:Male; D020097:Natriuretic Peptide, Brain; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000502:physiology*; D010525:Peripheral Nerves / Q000032:analysis; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D009419:Nerve Tissue Proteins; D020097:Natriuretic Peptide, Brain