[A method for understanding halothane-induced changes of cytosolic calcium concentrations in blood platelets].
A method will be presented for monitoring the halothane-induced changes of the cytosolic calcium concentration in blood platelets. Using the fluorescent indicator quin2 it was demonstrated for the first time that halothane causes a temporary increase of the cytosolic free calcium in platelets. The parameter Mean Cytosolic Calcium Concentration describes the halothane-induced changes quantitatively.
S
S
Fink
A
A
Bosia
J G
JG
Hofmann
D000634:Aminoquinolines; D001792:Blood Platelets / Q000032:analysis* / Q000187:drug effects; D002118:Calcium / Q000097:blood*; D003600:Cytosol / Q000032:analysis*; D005260:Female; D005456:Fluorescent Dyes; D005470:Fluorometry; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D008297:Male
D000634:Aminoquinolines; D005456:Fluorescent Dyes; C035739:Quin2; D002118:Calcium; D006221:Halothane
Eine Methode zur Erfassung halothaninduzierter Vernderungen der cytosolischen Calciumkonzentration in Blutplättchen.