[The pharmacokinetics of antilipemic agents. 5. Is 2-(4-hydroxyphenoxy)-2-methylpropionic acid a metabolite of the antilipemic ciprofibrate?].
After oral administration of Ciprofibrate (1) to volunteers (n = 5) only its glucuronide, but no 1 and no 2-(4-Hydroxyphenoxy)-2-methyl-propionic acid (3) could be detected in the fresh urine. Its formation from 1 seems to be impossible on the basis of established biochemical reactions. Therefore, its presence in the urine of volunteers reported by other authors is refuted.
Oelschläger
H
H
Rothley
D
D
Hellwich
K H
KH
Schmidt
W
W
D002994:Clofibrate / Q000031:analogs & derivatives*; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D058607:Fibric Acids; D006801:Humans; D000960:Hypolipidemic Agents / Q000493:pharmacokinetics*
D058607:Fibric Acids; D000960:Hypolipidemic Agents; D002995:Clofibric Acid; C060854:2-(4-hydroxyphenoxy)-2-methylpropionic acid; C019304:ciprofibrate; D002994:Clofibrate
Zur Pharmakokinetik von Lipidsenkern, T. Mitt. Ist 2-(4-Hydroxyphenoxy)-2-methyl-propionsäure ein Metabolit des Lipidsenkers Ciprofibrat?