Physiological characteristics of platelet serotonin in rats.
Physiological characteristics of platelet serotonin (5-HT) levels in rats of Wistar origin were investigated by use of a recently developed method. By comparison of populations of male and female rats (N = 281) similar unimodal frequency distributions, with a tendency to higher values in females (1.61 vs. 1.70 micrograms 5HT/mg platelet protein; p less than 0.01), were found. For a group of 55 animals, monitored twice for this parameter within a week interval, a remarkable intraindividual constancy in time, the mean difference between two determinations being 5.5%, was shown. No age-dependence could be demonstrated for platelet serotonin concentrations in 5- to 30-week-old rats, nor were there significant circadian or seasonal oscillations.
Department of Experimental Biology and Medicine, Ruder Bosković Institute, Zagreb, Yugoslavia.
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Jernej
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Cicin-Sain
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Kveder
D000375:Aging; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D001798:Blood Proteins / Q000032:analysis; D002940:Circadian Rhythm; D005260:Female; D008297:Male; D010507:Periodicity; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012621:Seasons; D012701:Serotonin / Q000097:blood*; D012737:Sex Factors
D001798:Blood Proteins; D012701:Serotonin