[Homeostasis of the auto-oscillation period in a model of a cellular circadian clock].
A mathematical model was numerically investigated which describes the autooscillatory temporal organization of futile cycles of the carbohydrate branch of energy metabolism. Using an optimization method we found a region in the parametric space of the model in which the circadian oscillation period was practically constant, although the major eight parameters varied in a wide range. Such homeostasis of the period is due to synergistic effects of the four feed-back mechanisms regulating activities of the key enzymes. The result obtained supports the metabolic theory of the circadian cell clock.
E E
EE
Sel'kov
L Ia
LIa
Lisnichuk
N V
NV
Avseenko
D050260:Carbohydrate Metabolism; D002940:Circadian Rhythm; D004734:Energy Metabolism; D006706:Homeostasis; D008433:Mathematics
Gomeostaz perioda avtokolebaniĭ v modeli tsirkadiannykh kletochnykh chasov.