Functional development of the visual system in normal and protein-deprived rats. VII. Lamination of oxidative enzyme activity in the visual cortex during post-natal development.
Lamination of activity of two mitochondrial enzymes-succinate dehydrogenase (SDH) and menadione-dependent alpha-glycerophosphate dehydrogenase (M-GPDH) - was examined in the visual cortex of control (C) and protein-deprived (PD) rats from 10 days old to adult. In C rats, lamination of enzyme activity was evident from 10 days by a band of higher activity in lamina IV. A band of higher SDH activity was seen in superficial lamina VI from 15 days. Lamination of M-GPDH activity became less pronounced with increasing age, whereas distinct bands of high SDH activity in lamina IV and VI remained also in adult rats. PD rats showed a developmental delay of approximately 5 days with regard to the general increase in neuropile activity. A band of higher enzyme activity in lamina IV was present from 10 days, but it was markedly less distinct in the PD rats compared to the C rats between 15 and 25 days. A band of higher SDH activity in superficial lamina VI was not seen until 25 days in PD rats. No apparent differences were seen between adult C and PD rats. The observed developmental alterations are discussed in relation to other delays, distortions and deficits found in the visual system of PD rats.
Department of Pathology, Gothenburg University, Sweden.
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Sjöström
D000818:Animals; D005260:Female; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism*; D006651:Histocytochemistry; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D010084:Oxidation-Reduction; D011247:Pregnancy; D011488:Protein Deficiency / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D014793:Visual Cortex / Q000201:enzymology* / Q000254:growth & development; D014812:Vitamin K / Q000378:metabolism*
D014812:Vitamin K; D005993:Glycerolphosphate Dehydrogenase; D013385:Succinate Dehydrogenase