Delayed hemolytic transfusion reactions in sickle cell anemia.
Delayed hemolytic transfusion reaction (DHTR) developed in three patients with sickle cell anemia seen over an 18-month period at Cook Country Hospital. The DHTR was associated with severe pain crisis, with spherocytic hemolytic anemia, a positive direct antiglobulin test result, previously undetected erythrocyte alloantibodies, and disappearance of Hb A on cellulose acetate electrophoresis. Delayed hemolytic transfusion reactions may be more common than is generally recognized and should be considered when a patient has a sickle cell pain crisis shortly after receiving a transfusion.
Rao
K R
KR
Department of Medicine, Cook Country Hospital, Chicago, Ill.
Patel
A R
AR
D000328:Adult; D000743:Anemia, Hemolytic / Q000097:blood / Q000209:etiology*; D000755:Anemia, Sickle Cell / Q000097:blood / Q000628:therapy*; D017707:Erythrocyte Transfusion; D006801:Humans; D008297:Male; D013997:Time Factors; D065227:Transfusion Reaction