[Retinoic acid effect on the differentiation of blast cells in suspension].
Cells from three patients showed maturation after incubation with retinoic acid (2 had M-3 AML and 1 had CML-B). Three additional patients showed spontaneous maturation (1 with M-2 and 2 with M-4 AML), and in them cell maturation was also achieved after incubation with retinoic acid and cytosine arabinoside (10 nM). These results confirm different maturation capability of leukaemic cells, as well as the possibility to induce cellular maturation with retinoic acid, especially in patients with acute promyelocytic leukaemia (M-3).
Burgaleta
C
C
Moreno
T
T
Sánchez Godoy
P
P
D000328:Adult; D000368:Aged; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008875:Middle Aged; D014212:Tretinoin / Q000494:pharmacology*
D014212:Tretinoin
Efecto del ácido retinoico sobre la diferenciación de células blásticas en suspensión.