[Effect of tumor-promoting phorbol esters on retrovirus-infected human cells: scanning electron microscopy studies].
The effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on cultivated human cells infected with a human cell line derived retrovirus were examined by using scanning electron microscopy. The most prominent immediate morphological changes were the rounding up of cell surfaces, an enhanced formation of blebs and an increasing tendency to cell detachment. The production of virus particles under TPA treatment was markedly augmented, reaching 300 to 500 particles in individual cells. The production of particles appeared nearly random over the cell surface.
Zentralinstitut für Krebsforschung, Akademie der Wissenschaften der DDR, Berlin.
M
M
Rudolph
V
V
Wunderlich
L
L
Baumbach
D002460:Cell Line; D002472:Cell Transformation, Viral / Q000187:drug effects*; D005260:Female; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010051:Ovarian Neoplasms; D012190:Retroviridae / Q000235:genetics*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000648:ultrastructure
D013755:Tetradecanoylphorbol Acetate
Wirkung eines tumorpromovierenden Phorbolesters auf Retrovirus-infizierte menschliche Zellen: Rasterelektronenmikroskopische Untersuchungen.