A stochastic two-stage model for cancer risk assessment. II. The number and size of premalignant clones.
Mathematical expressions are derived, under different dosing patterns, for the number and size of premalignant clones within the framework of a two-mutation model for carcinogenesis, which has previously been shown to be consistent with a large body of epidemiologic and experimental data.
Dewanji
A
A
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington 98104.
Venzon
D J
DJ
Moolgavkar
S H
SH
D000818:Animals; D002452:Cell Count; D002999:Clone Cells / Q000473:pathology; D003043:Cocarcinogenesis; D008954:Models, Biological; D008962:Models, Theoretical; D011230:Precancerous Conditions / Q000209:etiology* / Q000473:pathology; D012306:Risk; D013269:Stochastic Processes; D013997:Time Factors