The 21-aminosteroid U74006F reduces systemic lipid peroxidation, improves neurologic function, and reduces mortality after cardiopulmonary arrest in dogs.
Natale
J E
JE
Department of Physiology, University of Michigan Medical School, Ann Arbor 48109.
Schott
R J
RJ
Hall
E D
ED
Braughler
J M
JM
D'Alecy
L G
LG
D000818:Animals; D004285:Dogs; D005227:Fatty Acids / Q000097:blood; D006323:Heart Arrest / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D007700:Kinetics; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors* / Q000097:blood; D008297:Male; D009420:Nervous System / Q000503:physiopathology*; D011281:Pregnatrienes / Q000627:therapeutic use*; D014810:Vitamin E / Q000097:blood
D005227:Fatty Acids; D008054:Lipid Peroxides; D011281:Pregnatrienes; D014810:Vitamin E; C053355:tirilazad