Long-term follow-up of membranoproliferative glomerulonephritis type II and pregnancy: a case report.
A 24-year-old female was diagnosed as having membranoproliferative glomerulonephritis type II (or dense deposit disease), 11 years prior to becoming pregnant. The patient's first renal biopsy was performed 5 years after the onset of her renal symptoms. This biopsy was compared to a second renal biopsy taken just before the patient became pregnant. The second renal biopsy only showed a slight progression in the disease process. During the course of pregnancy, neither renal insufficiency nor hypertension were clinically evident. However, both an increase in proteinuria and a transient hypoalbuminemia were observed. The pregnancy, labor and delivery, and postpartum course for both the mother and child were without complications. Cases of membranoproliferative glomerulonephritis type I and pregnancy have been reported. However, to our knowledge, there are few reports documenting the outcome of pregnancy when a patient has membranoproliferative glomerulonephritis type II. We suggest that it is possible for a patient with membranoproliferative glomerulonephritis type II to have an uneventful pregnancy if she has neither hypertension nor renal insufficiency.
Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
S
S
Inaba
T
T
Tanizawa
T
T
Igarashi
A
A
Higuchi
H
H
Satou
D
D
Mase
R
R
Asada
Y
Y
Suzuki
T
T
Okada
D000328:Adult; D001485:Basement Membrane / Q000648:ultrastructure; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D015432:Glomerulonephritis, Membranoproliferative / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D008854:Microscopy, Electron; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D013997:Time Factors