Sensitivity of selected drug biotransformation enzymes to dietary protein levels in adult F344 male rats.
Adult male Fischer 344 rats were fed inadequate, adequate, and excessive quantities of dietary protein (8, 12, and 22%, respectively) for a period of 14 days. An increase in dietary protein did not increase liver weight but resulted in an increase in cytochrome P-450 content and 7-ethoxycoumarin O-deethylase activity. No significant difference in glutathione S-transferase activity was observed at the three protein levels. The in vivo hepatotoxicity of bromobenzene increased with an elevation in dietary protein intake from 12 to 22%. These data from mature rats follow trends similar to findings we have reported previously with juvenile rats.
Toxicology Program, North Carolina State University, Raleigh 27695-7633.
L E
LE
Butler
W C
WC
Dauterman
D000818:Animals; D001711:Biotransformation; D001835:Body Weight / Q000187:drug effects; D001969:Bromobenzenes / Q000494:pharmacology; D004044:Dietary Proteins / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344
D001969:Bromobenzenes; D004044:Dietary Proteins; D004364:Pharmaceutical Preparations; D006899:Mixed Function Oxygenases