Efficacy of levamisole against immature and mature nematodes in goats with induced infections.
Anthelmintic efficacy of levamisole against induced infections with 7- and 21-day-old Haemonchus contortus, Ostertagia circumcincta, Trichostrongylus axei, and T colubriformis was evaluated as an oral drench in goats. Group 1 (n = 8) was not treated, group 2 (n = 8) was given 3.96 mg of levamisole/kg of body weight, group 3 (n = 8) was given 7.92 mg of levamisole/kg, and group 3 (n = 7) was given 11.88 mg of levamisole/kg. Efficacy against all worms was low in goats given 3.96 mg of levamisole/kg, but was high against adult H contortus (99%) and adult T colubriformis (99.7%) in goats given 7.92 mg of levamisole/kg. Although efficacy against adults of all species was high in goats given 11.88 mg of levamisole/kg, some immature worms of all species remained in the abomasa of goats.
Coles
G C
GC
Department of Zoology, University of Massachusetts, Amherst 01003.
Giordano
D J
DJ
Tritschler
J P
JP
D000818:Animals; D004304:Dosage Forms; D005260:Female; D006041:Goats / Q000469:parasitology*; D006188:Haemonchiasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D007814:Larva / Q000187:drug effects; D007978:Levamisole / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010029:Ostertagiasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D014252:Trichostrongyloidiasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D014253:Trichostrongylosis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary
D004304:Dosage Forms; D007978:Levamisole