Behavioral consequences of prenatal exposure to the organophosphate insecticide sumithion.
Prenatal administration of Sumithion 50 EC, an organophosphate insecticide, to CFY rats at 5, 10 and 15 mg/kg from days 7 to 15 of gestation, resulted in dose related decreases in open field activity and motor coordination in the offspring treated with the two higher doses. Long lasting alterations in the acquisition and extinction of a conditioned escape response, as well as increased social interactions were observed in the adult offspring. The results indicate a no effect level at 5 mg/kg under the experimental conditions in the present study.
State Institute of Occupational Health, Budapest, Hungary.
K
K
Lehotzky
M J
MJ
Szeberenyi
A
A
Kiss
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003213:Conditioning, Psychological / Q000187:drug effects; D004924:Escape Reaction / Q000187:drug effects; D005260:Female; D005278:Fenitrothion / Q000633:toxicity*; D008297:Male; D008431:Maternal-Fetal Exchange; D009943:Organophosphorus Compounds / Q000633:toxicity; D011247:Pregnancy; D051381:Rats; D013216:Reflex, Startle / Q000187:drug effects
D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D005278:Fenitrothion