[Pharmacokinetics of cisplatin and vindesine in a patient with chronic renal failure undergoing hemodialysis].
Plasma total platinum and vindesine levels were monitored in a patient with chronic renal failure undergoing hemodialysis. Plasma levels of cisplatin were determined as platinum by atomic absorption spectrophotometry, and plasma vindesine levels were measured by radioimmunoassay. Fifty mg. of cisplatin in combination with 3 mg. of vindesine were infused for 60 minutes before dialysis. During dialysis, plasma total platinum levels decreased rapidly in a biphasic fashion and 1.76 at 30 hours after infusion. Plasma vindesine levels declined with higher concentration. In conclusion, it is considered that cisplatin and vindesine can be given to anuric patients undergoing hemodialysis. However, it is suggested that smaller doses should be given to prevent side effects.
First Dept. of Surgery, Nagasaki University Hospital.
H
H
Ayabe
T
T
Uchikawa
K
K
Kimino
Y
Y
Tagawa
K
K
Kawahara
M
M
Tomita
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy; D006435:Renal Dialysis; D014751:Vindesine / Q000008:administration & dosage / Q000493:pharmacokinetics*
D002945:Cisplatin; D014751:Vindesine