[Chromopharmacokinetics of acetylsalicylic acid administered rectally the rabbit].
Five white rabbits are given by rectal route a single dose of 100 mg of Aspirin at regular hours: 7 a.m.; 10 a.m. and 2 p.m. the 7 a.m. administration results in lowest CMAX and AUC and the slowest elimination, whereas 10 a.m. and 2 p.m. administration results in the highest CMAX and AUC and shortest elimination time.
B
B
Fehri
J M
JM
Aiache
K
K
Boukef
D000285:Administration, Rectal; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D011817:Rabbits
D001241:Aspirin
Chronopharmacocinétique de l'acide acétylsalicylique administré par voie rectale chez le lapin.