Urinary citrate excretion in patients with urolithiasis and normal subjects.
Citrate is a normal constituent of urine which combines with calcium to form a soluble salt. Urinary citrate excretion was examined in patients with urolithiasis and normal subjects by a specific enzymatic technique. There was a considerable overlap in the urinary citrate excretion between normal subjects and stone-formers, but the citrate-creatinine ratio, the citrate-calcium ratio and the citrate-magnesium-calcium ratio, which were all highly significantly lower (p less than 0.001) in stone-formers than in controls, proved most reliable in discriminating between these groups.
Department of Clinical Sciences, University of Tampere, Finland.
M
M
Nikkilä
T
T
Koivula
H
H
Jokela
D002118:Calcium / Q000652:urine; D002951:Citrates / Q000652:urine*; D019343:Citric Acid; D005260:Female; D006801:Humans; D008274:Magnesium / Q000652:urine; D008297:Male; D008875:Middle Aged; D014545:Urinary Calculi / Q000652:urine*
D002951:Citrates; D019343:Citric Acid; D008274:Magnesium; D002118:Calcium