Decreased poststenotic flow disturbance during drag reduction by polyacrylamide infusion without increased aortic blood flow.
The infusion of polyacrylamide in open chest rats has been reported to increase aortic blood flow and the effect has been ascribed to the "drag reduction" properties of these compounds. In six anesthetized dogs the infusion of polyacrylamide to a total dose of 2 mg/kg caused a reduction in midline and separation zone Doppler spectral broadening in the common carotid artery poststenotic velocity field. This apparent reduction in poststenotic turbulence was interpreted as indicating the presence of a drag reducing effect. Despite this demonstration that polyacrylamide was present in the blood in drag reducing concentrations no increase in aortic blood flow was produced.
Hutchison
K J
KJ
Department of Physiology, University of Alberta, Edmonton, Canada.
Campbell
J D
JD
Karpinski
E
E
D000180:Acrylic Resins / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000502:physiology*; D001783:Blood Flow Velocity / Q000187:drug effects; D002339:Carotid Arteries / Q000473:pathology / Q000503:physiopathology; D003251:Constriction, Pathologic / Q000503:physiopathology; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects*; D000099166:Polyacrylamides
D000180:Acrylic Resins; D000099166:Polyacrylamides