Pulmonary vascular and renal effects of cromakalim in anaesthetized dogs.
1) CROM reduced hypoxia-induced pulmonary vasoconstriction and maintained PaO2 with an increase in cardiac output. 2) Low doses of CROM infused into the kidney caused pronounced renal vasodilation, marked natriuresis and a significant increase in cardiac output with minor changes in blood pressure. In addition to its previously described systemic antihypertensive effects, CROM also reduces hypoxia-induced pulmonary hypertension and shows marked renal vasodilation with natriuresis in anaesthetized dogs.
Department of Pharmacology, Recherche Syntex France, Montlhery.
P E
PE
Hicks
D
D
Martin
D
D
Dumez
E
E
Zazzi-Sudriez
J M
JM
Armstrong
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects*; D019806:Cromakalim; D004285:Dogs; D007668:Kidney / Q000098:blood supply / Q000187:drug effects*; D015221:Potassium Channels / Q000187:drug effects*; D011652:Pulmonary Circulation / Q000187:drug effects*; D011758:Pyrroles / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D001578:Benzopyrans; D015221:Potassium Channels; D011758:Pyrroles; D014665:Vasodilator Agents; D019806:Cromakalim