Effects of perphenazine, chlorpromazine or CoCl2 on the activities of delta-aminolevulinic acid synthetase and heme oxygenase and on the content of hemoprotein in rat liver.
Administration of CoCl2 caused a marked decrease of hepatic drug-metabolizing enzymes and the induction of delta-aminolevulinic acid (delta-ALA) synthetase and heme oxygenase. Under the same experimental condition, the inverse relationship between the decrease of hepatic drug-metabolizing enzymes and delta-ALA synthetase activity and the increase of heme oxygenase activity was observed in perphenazine (PPZ)- or chlorpromazine (CPZ)-treated rats. However, the decrease of cytochrome P-450 and aniline hydroxylase by CPZ was later restored or increased over the control level. In addition, CPZ resulted in a marked decrease of total heme content, but this content was not changed by PPZ.
Senda
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Department of Pharmacology, Hokkaido Institute of Pharmaceutical Sciences, Otaru, Japan.
Hoshi
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Fujino
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D000624:5-Aminolevulinate Synthetase / Q000096:biosynthesis*; D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D003035:Cobalt / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis*; D006420:Hemeproteins / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D010546:Perphenazine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D006420:Hemeproteins; D003035:Cobalt; D006899:Mixed Function Oxygenases; D006419:Heme Oxygenase (Decyclizing); D000624:5-Aminolevulinate Synthetase; C018021:cobaltous chloride; D010546:Perphenazine; D002746:Chlorpromazine