Protective effect of anethol dithiolthione against acetaminophen hepatotoxicity in mice.
Anethol dithiolthione (ADT), usually prescribed as a choleretic drug, when given orally 1 hour prior to acetaminophen (AAP) (450 mg/kg intraperitoneally) in Swiss female mice, exhibited an hepatoprotective potency at doses as low as 10 mg/kg relative to serum aminotransferase activities and hepatic glutathione related enzyme system (glutathione reductase, peroxidase, transferase). These preliminary results are relevant with the use of pharmacologic dosage of ADT in hepatotoxicity prevention.
Toxicological Laboratory, Faculty of Pharmacy, Paris, France.
J M
JM
Warnet
M O
MO
Christen
M
M
Thevenin
D
D
Biard
A
A
Jacqueson
J R
JR
Claude
D000082:Acetaminophen / Q000633:toxicity*; D000781:Anethole Trithione / Q000494:pharmacology*; D000818:Animals; D000840:Anisoles / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D051379:Mice
D000840:Anisoles; D000082:Acetaminophen; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione; D000781:Anethole Trithione