Tetrahydrobiopterin metabolism in the streptozotocin induced diabetic state in rats.
Streptozotocin induced diabetes has been shown to have associated changes in the metabolism of tetrahydrobiopterin. De novo biosynthesis of tetrahydrobiopterin in the brain was reduced as was dihydropteridine reductase activity. Consequently there is a shift from fully reduced biopterins to more oxidised species. Both can cause reduced levels in the cofactor pool and may cause reduced levels of the associated neurotransmitters and neurological deficits.
Pharmaceutical Sciences Institute, Aston University, Aston Triangle, Birmingham, UK.
C G
CG
Hamon
P
P
Cutler
J A
JA
Blair
D000818:Animals; D001708:Biopterins / Q000031:analogs & derivatives* / Q000378:metabolism / Q000502:physiology; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology / Q000378:metabolism*; D004093:Dihydropteridine Reductase / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D001708:Biopterins; D004093:Dihydropteridine Reductase; C003402:sapropterin