Platelet GABA-aminotransferase in epileptic patients.
Platelet GABA-aminotransferase (GABA-T) activity was determined in 12 adults (six healthy volunteers and six long-term treated epileptic patients) and 17 children (six non-epileptic, and 11 long-term treated epileptic patients). Platelet GABA-T activity was about 60% higher in the epileptic patients than in the controls, both in adults (14.7 +/- 8.6 versus 8.8 +/- 3.5 pmol/min/mg of protein,) and children (13.1 +/- 4.8 versus 8.3 +/- 3.3 pmol/min/mg of protein, p less than 0.05). The relationship between this increase and either epilepsy or anti-epileptic treatment should be clarified in further studies.
Department of Clinical Pharmacology, M. de Valdecilla National Hospital, University of Cantabria, Spain.
J A
JA
Armijo
R
R
Arteaga
R
R
Valiente
J L
JL
Herranz
D000612:4-Aminobutyrate Transaminase / Q000097:blood*; D000328:Adult; D000367:Age Factors; D001792:Blood Platelets / Q000201:enzymology*; D002648:Child; D004827:Epilepsy / Q000097:blood / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male
D000612:4-Aminobutyrate Transaminase