The hyperventilation-induced ischaemia model in human neuropharmacology: neurophysiological and psychometric studies of aniracetam and 3-OH aniracetam.
Standardized hyperventilation in young subjects induces changes in the EEG, a decrease in the velocity of the cerebral blood flow and a decline in cognitive performance, which are comparable to those occurring in patients with cerebral ischaemia. The anti-ischaemic properties of aniracetam and 3-OH aniracetam were tested in this model. A single oral dose of 3-OH aniracetam 1500 mg appeared to have the most pronounced effect on hyperventilation-induced EEG changes and cognitive deterioration. The test drugs had no effect on the heart rate or blood flow velocity. The effects agree with those of other drugs classified as noötropics.
Kraaier
V
V
University Hospital Utrecht, Department of Clinical Neurophysiology, The Netherlands.
van Huffelen
A C
AC
Wieneke
G H
GH
D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D004311:Double-Blind Method; D004569:Electroencephalography; D006801:Humans; D006985:Hyperventilation; D008297:Male; D008568:Memory / Q000187:drug effects; D011760:Pyrrolidinones / Q000494:pharmacology* / Q000627:therapeutic use
D011760:Pyrrolidinones; C036466:aniracetam; C061073:3-hydroxyaniracetam