Intestinal blood flow and oxygen consumption: responses to hemorrhage in the developing piglet.
Age-related differences in the intestinal hemodynamic and oxygenation responses to arterial hemorrhage were studied in anesthetized and ventilated 1-d, 3-d, 1-wk, and 2-wk-old piglets. Steady-state values of superior mesenteric blood flow, venous pressure, and arteriovenous oxygen difference were obtained before and after 5 and 10 mL/kg arterial hemorrhage. With 5 mL/kg hemorrhage, intestinal blood flow fell significantly below baseline values, but oxygen extraction increased to maintain oxygen uptake at control levels in all age groups. In contrast to 2-wk-old piglets, the intestine of 1-d, 3-d, and 1-wk-old animals could not compensate for the greater reduction in blood flow produced by 10 mL/kg hemorrhage, resulting in a significant reduction in oxygen uptake. Thus, the intestine of developing piglets up to 1 wk of age appears to be at greater risk for tissue hypoxia induced by arterial hemorrhage than that of older animals.
Department of Physiology and Biophysics, Louisiana State University Medical Center, Shreveport 71130.
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Crissinger
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Granger
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001794:Blood Pressure; D005260:Female; D006470:Hemorrhage / Q000378:metabolism / Q000503:physiopathology*; D007421:Intestine, Small / Q000098:blood supply* / Q000378:metabolism*; D008297:Male; D010101:Oxygen Consumption; D013552:Swine; D014655:Vascular Resistance