v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.
Cas NS-1 is an acutely transforming murine retrovirus that induces pre-B and pro-B cell lymphomas. Molecular cloning showed it was generated from the ecotropic Cas-Br-M virus by sequential recombinations with endogenous retroviral sequences and a cellular oncogene. The oncogene sequence shows no homology with known oncogenes but some similarity to the yeast transcriptional activator GCN4. A 100-kDa gag-cbl fusion protein, with no detectable kinase activity, is responsible for the cellular transformation. The cellular homologue of v-cbl, present in mouse and human DNA, is expressed in a range of hemopoietic lineages.
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.
W Y
WY
Langdon
J W
JW
Hartley
S P
SP
Klinken
S K
SK
Ruscetti
H C
HC
Morse
D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes; D001483:Base Sequence; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D003001:Cloning, Molecular; D008223:Lymphoma / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D050722:Oncogene Protein v-cbl; D009857:Oncogenes; D051381:Rats; D015183:Restriction Mapping; D012190:Retroviridae / Q000235:genetics*; D012191:Retroviridae Proteins / Q000235:genetics*; D015682:Retroviridae Proteins, Oncogenic
D050722:Oncogene Protein v-cbl; D012191:Retroviridae Proteins; D015682:Retroviridae Proteins, Oncogenic