Functional development of the visual system in normal and protein-deprived rats. VII. Lamination of oxidative enzyme activity in the visual cortex during post-natal development.
Lamination of activity of two mitochondrial enzymes-succinate dehydrogenase (SDH) and menadione-dependent alpha-glycerophosphate dehydrogenase (M-GPDH) - was examined in the visual cortex of control (C) and protein-deprived (PD) rats from 10 days old to adult. In C rats, lamination of enzyme activity was evident from 10 days by a band of higher activity in lamina IV. A band of higher SDH activity was seen in superficial lamina VI from 15 days. Lamination of M-GPDH activity became less pronounced with increasing age, whereas distinct bands of high SDH activity in lamina IV and VI remained also in adult rats. PD rats showed a developmental delay of approximately 5 days with regard to the general increase in neuropile activity. A band of higher enzyme activity in lamina IV was present from 10 days, but it was markedly less distinct in the PD rats compared to the C rats between 15 and 25 days. A band of higher SDH activity in superficial lamina VI was not seen until 25 days in PD rats. No apparent differences were seen between adult C and PD rats. The observed developmental alterations are discussed in relation to other delays, distortions and deficits found in the visual system of PD rats.
Conradi
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NG
Department of Pathology, Gothenburg University, Sweden.
Sjöström
A
A
D000818:Animals; D005260:Female; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism*; D006651:Histocytochemistry; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D010084:Oxidation-Reduction; D011247:Pregnancy; D011488:Protein Deficiency / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D014793:Visual Cortex / Q000201:enzymology* / Q000254:growth & development; D014812:Vitamin K / Q000378:metabolism*
D014812:Vitamin K; D005993:Glycerolphosphate Dehydrogenase; D013385:Succinate Dehydrogenase