Kinetics of mast cells, eosinophils and phospholipase B activity in the spontaneous-cure response of two strains of mice (rapid and slow responder) to the cestode Hymenolepis nana.
Primary egg-derived infection of Hymenolepis nana (100 eggs) in BALB/c (rapid responder) and C3H (slow responder) mice resulted in increased levels of mucosal mast cells (MMCs), eosinophilia (bone marrow, peripheral, tissue) and phospholipase B activity. The response appeared to be similar in both strains used, with a slight difference in cellular accumulation but a significantly earlier response in BALB/c than in C3H mice. These findings suggest that the prolongation of H. nana infection in C3H mice may be related to the delayed appearance of MMCs and eosinophils, which triggers a slower generation of the intestinal inflammation response. The rapidity with which phospholipase B activity increased was strictly correlated with eosinophil tissue number; this further supports the hypothesis for a direct parallel between eosinophils and phospholipase B activity in infected tissue.
Bortoletti
G
G
Istituto di Parassitologia, Università di Cagliari, Italy.
Gabriele
F
F
Palmas
C
C
D000818:Animals; D002452:Cell Count; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D006925:Hymenolepiasis / Q000201:enzymology / Q000276:immunology*; D007422:Intestines / Q000469:parasitology; D007700:Kinetics; D007958:Leukocyte Count; D008245:Lysophospholipase / Q000378:metabolism*; D008407:Mast Cells / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D010740:Phospholipases / Q000378:metabolism*
D010740:Phospholipases; D008245:Lysophospholipase