Perimembranous-type renal amyloidosis: a peculiar form of AL amyloidosis.
Six cases of perimembranous-type renal amyloidosis were reported. This type of renal amyloidosis was characterized by amyloid deposition predominantly involving the epithelial aspect of the glomerular capillary wall. Florid spicular arrangement was another representative feature. This type of amyloid deposition was found in 8% of autopsy cases of systemic amyloidosis. All cases were categorized as AL amyloidosis and developed the nephrotic syndrome irrespective of the amount of amyloid within the glomeruli. The results obtained suggest that perimembranous-type renal amyloidosis is a peculiar form of AL amyloidosis both in morphology and clinical manifestations. autopsy cases of systemic amyloidosis. All cases were categorized as AL amyloidosis and developed the nephrotic syndrome irrespective of the amount of amyloid within the glomeruli. The results obtained suggest that perimembranous-type renal amyloidosis is a peculiar form of AL amyloidosis both in morphology and clinical manifestations. autopsy cases of systemic amyloidosis. All cases were categorized as AL amyloidosis and developed the nephrotic syndrome irrespective of the amount of amyloid within the glomeruli. The results obtained suggest that perimembranous-type renal amyloidosis is a peculiar form of AL amyloidosis both in morphology and clinical manifestations.
Department of Pathology, Saga Medical School, Japan.
H
H
Shiiki
T
T
Shimokama
Y
Y
Yoshikawa
K
K
Onoyama
M
M
Morimatsu
T
T
Watanabe
D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D001485:Basement Membrane / Q000648:ultrastructure; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000648:ultrastructure; D008854:Microscopy, Electron; D009101:Multiple Myeloma / Q000150:complications; D009404:Nephrotic Syndrome / Q000209:etiology / Q000473:pathology
D000682:Amyloid