[Amino acid composition and properties of fibrin self-assembly inhibitors].
Three peptides, inhibitors of fibrin self-assembly, were shown to be responsible for stable antipolymerization activity of blood plasma. Similarity of amino acid composition of these inhibitors might be considered as an indication of their origin from a common precursor by means of limited proteolysis. Inhibition of the self-assembly occurred due to interaction of the peptides with monomeric fibrin in the region of domain D, which was accompanied by loosening of electrostatic interactions between molecules of fibrin.
E A
EA
Chiriat'ev
O P
OP
Leonova
A Sh
ASh
Byshevskiĭ
D000596:Amino Acids / Q000032:analysis*; D002850:Chromatography, Gel; D005337:Fibrin / Q000037:antagonists & inhibitors*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D010455:Peptides / Q000032:analysis* / Q000097:blood*; D013056:Spectrophotometry, Ultraviolet
D000596:Amino Acids; D010455:Peptides; D005337:Fibrin; C052940:fibrin self-assembly inhibitor
Aminokislotnyĭ sostav i svoĭstva ingibitorov samosborki fibrina.