DNA haplotypes and frameworks linked to the beta-globin locus in an Austro-Asiatic population with a high prevalence of hemoglobin E.
DNA haplotypes (HT) and frameworks (FW) linked to the beta-globin locus were determined by restriction fragment analysis using eight restriction enzymes on chromosomes bearing the Hb A gene (HBB*A) or the HbE gene (HBB*E) in the So, an Austro-Asiatic population of northeast Thailand with an HBB*E frequency near 0.5. All HBB*E genes were present with FW2, and only two haplotypes were observed (25 HT 27-2, -+- +-; 10 HT 41-2, +----++-). In a control group from the general population of Northeast Thailand the HT distribution was more diverse, and 2 of 20 HBB*E genes were present in FW 3. High frequencies of HBB*E in FW 3 in Southeast Asia are apparently limited to the Khmer population of Cambodia. There were no differences in the hematologic parameters in subjects homozygous for HBB*E/FW2 or HBB*E/FW3.
Department of Biochemistry, Faculty of Medicine, Khonkaen University, Thailand.
P
P
Yongvanit
P
P
Sriboonlue
N
N
Mularlee
T
T
Karnthong
P
P
Areejitranusorn
J
J
Hundrieser
R
R
Limberg
B
B
Schulze
M
M
Laig
S D
SD
Flatz
D004247:DNA / Q000235:genetics*; D008040:Genetic Linkage; D005838:Genotype; D005914:Globins / Q000235:genetics*; D006239:Haplotypes; D006446:Hemoglobin E / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D015183:Restriction Mapping; D013785:Thailand
D006455:Hemoglobins, Abnormal; D005914:Globins; D004247:DNA; D006446:Hemoglobin E