Capillary-isotachophoretic determination of glutamine in cerebrospinal fluid of various neurological disorders.
A rapid and microscale technique to detect and determine L-glutamine (Gln), which is the most abundant free amino acid in human cerebrospinal fluid (Sf), was established on the basis of capillary-isotachophoresis. This system was applied to the measurement of Sf Gln concentration in various neurological disorders. The results showed that Sf Gln was increased under some pathological conditions in the central nervous system, especially those accompanying pleocytosis in Sf.
Hiraoka
A
A
Kyorin University School of Health Sciences, Tokyo, Japan.
Miura
I
I
Tominaga
I
I
Hattori
M
M
D001927:Brain Diseases / Q000134:cerebrospinal fluid*; D004586:Electrophoresis; D005973:Glutamine / Q000134:cerebrospinal fluid*; D006801:Humans; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid*
D005973:Glutamine