[Morphology, clinical aspects and therapy of perinatal hypoxic central nervous system damage. A pedoneuropsychiatric follow-up analysis in relation to the neurohistologic spectrum of findings].
The histological localization and extent of ZNS-lesions caused by perinatal hypoxia has been examined in 83 cases. The neuropsychiatrical patterns of 71 in preschool and school age children after perinatal hypoxia were also investigated. Predominantly a brain stem damage with nerve cells lesions, hemorrhages and disturbance of neuroglia are found. In 1 fourth of the cases, nerve cell damage was localized in the medulla spinalis. Intramedullar hemorrhages can be observed in 10% of the cases. 41% of the cases showed subarachnoidal bleedings. Neuropsychiatrical examinations showed varying degrees of brain stem dysfunction in accordance with neurohistological findings. 1 third of the risk children demonstrated minimal brain dysfunction. In 10% an early rehabilitation of resulted in an amelioration of the ZNS-function. Special attention should be drawn to partial ZNS-disturbance-children. The problems of therapy are discussed.
Quandt
J
J
Neuropsychiatrischen Abteilung Kreiskrankenhauses Köthen, DDR.
Goertchen
R
R
Kopp
E M
EM
Sommer
H
H
D000293:Adolescent; D001238:Asphyxia Neonatorum / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001925:Brain Damage, Chronic / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005313:Fetal Death / Q000473:pathology; D005317:Fetal Growth Retardation / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D002534:Hypoxia, Brain / Q000473:pathology*; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000473:pathology*; D007859:Learning Disabilities / Q000473:pathology; D008297:Male; D019965:Neurocognitive Disorders / Q000473:pathology; D009483:Neuropsychological Tests; D011247:Pregnancy; D012307:Risk Factors; D013116:Spinal Cord / Q000473:pathology*
Beitrag zur Morphologie, Klinik und Therapie der perinatalen hypoxischen ZNS-Schädigung. Eine paidoneuropsychiatrische Verlaufsanalyse in Beziehung zum neurohistologischen Befundkomplex.