[A decrease in the level of unscheduled DNA synthesis in preparations of irradiated rat hepatocyte nuclei under the effect of polyamines].
The results obtained show the possibility of polyamine (spermine and spermidine) utilization to stabilize the nuclear chromatin and to protect it against nuclease degradation in the course of isolation of liver cell nuclei. Besides, the inhibition of the unscheduled DNA synthesis induced by nuclease incision and by gamma- or UV-radiation was demonstrated in the presence of polyamines.
V G
VG
Bezlepkin
R A
RA
Namvar
M G
MG
Lomaeva
A I
AI
Gaziev
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002467:Cell Nucleus / Q000187:drug effects / Q000528:radiation effects*; D002843:Chromatin / Q000187:drug effects; D004260:DNA Repair / Q000187:drug effects*; D005720:Gamma Rays; D008099:Liver / Q000187:drug effects*; D008297:Male; D019384:Nucleic Acid Synthesis Inhibitors; D011073:Polyamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013095:Spermidine / Q000494:pharmacology; D013096:Spermine / Q000494:pharmacology; D014466:Ultraviolet Rays
D002843:Chromatin; D019384:Nucleic Acid Synthesis Inhibitors; D011073:Polyamines; D013096:Spermine; D002118:Calcium; D013095:Spermidine
Snizhenie urovnia vneplanovogo sinteza DNK v preparatakh obluchennykh iader gepatotsitov krys pod vliianiem poliaminov.