Cocaine increases extracellular dopamine in rat nucleus accumbens and ventral tegmental area as shown by in vivo microdialysis.
In vivo microdialysis measurements of extracellular dopamine (DA) were made simultaneously in nucleus accumbens (NAS) and ventral tegmental area (VTA) in anesthetized rats. Intravenous cocaine (1 mg/kg) resulted in rapid increases in DA in both NAS and VTA. The DA increase in NAS was greater in magnitude and persisted longer than that in VTA. The relevance of the observed effects to reported effects of cocaine on firing rate of mesoaccumbens DA neurons is discussed.
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510.
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Bradberry
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Roth
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003042:Cocaine / Q000494:pharmacology*; D003956:Dialysis; D004298:Dopamine / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism; D012686:Septal Nuclei / Q000378:metabolism*; D013681:Tegmentum Mesencephali / Q000378:metabolism*
D011954:Receptors, Dopamine; D003042:Cocaine; D004298:Dopamine