Facilitation of retention performance in mice by pretest microinjection of AVP into dorsal or ventral hippocampus: differential influence of the peptide on appetitive task.
Pre-test local microinjection of arginine-vasopressin (AVP) into dorsal or ventral hippocampus resulted in an improvement of retention performance in an appetitively motivated task. Nevertheless, a better improvement appeared when AVP treatment was performed into ventral hippocampus suggesting a higher sensitivity of this part of hippocampus to the action of AVP. To examine a non-specific behavioral action of the peptide, the effect of AVP treatment on locomotor activity was assessed. When the treatment was given into ventral hippocampus, a reduction of locomotor activity was recorded, whereas after AVP injection into dorsal hippocampus, the peptide failed to alter locomotor activity.
Laboratoire de Neurobiologie des Comportements, CNRS U.R.A. 372, Université de Provence, Marseille, France.
D
D
Metzger
B
B
Alescio-Lautier
B
B
Soumireu-Mourat
D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects; D001127:Arginine Vasopressin / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects
D001127:Arginine Vasopressin