Drugs in hair: a new extraction procedure.
An enzymatic hydrolysis of hair for drug detection is described. The results obtained with the suggested method are compared with those observed by chemical hydrolysis. Enzymatic digestion provides a high recovery (80%) for cocaine metabolite, while alkaline hydrolysis causes its chemical destruction. The two hydrolytic procedures yielded comparable results for morphine. The outlined procedure is recommended when unstable compounds are to be detected in hair.
Offidani
C
C
Institute of Forensic Medicine, Università Cattolica del Sacro Cuore, Roma, Italy.
Carnevale
A
A
Chiarotti
M
M
D003042:Cocaine / Q000031:analogs & derivatives* / Q000032:analysis; D006197:Hair / Q000032:analysis*; D006801:Humans; D006868:Hydrolysis; D009020:Morphine / Q000032:analysis*; D019966:Substance-Related Disorders / Q000378:metabolism
C005618:benzoylecgonine; D009020:Morphine; D003042:Cocaine