A comparative study of creatinine clearance rate in type I (IDDM) and II (NIDDM) diabetic patients.
The endogenous creatinine clearance test was done in 14 Type I and 15 Type II poorly controlled diabetic patients and compared with respective age matched healthy volunteers. Type I diabetics had significantly lower creatinine clearance rate, body mass index and serum albumin levels when compared to their control group. In Type II diabetics these values remained unaltered. Both Type I and Type II diabetics had significantly higher blood sugar and glycosylated haemoglobin levels. The creatinine clearance rate had significant positive correlation with patients' body mass index and serum albumin levels. This suggests that the undernutrition of Type I diabetics may be responsible for the decreased creatinine clearance.
Department of Pharmacology, Jawaharlat Institute of Postgraduate Medical Education and Research, Pondicherry.
C
C
Adithan
G
G
Sriram
R P
RP
Swaminathan
C H
CH
Shashindran
M
M
Krishanan
J S
JS
Bapna
S
S
Chandrasekar
D000328:Adult; D001774:Blood Chemical Analysis; D003404:Creatinine / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status
D003404:Creatinine