[New elements in the diagnosis and treatment of thyrotropic pituitary adenomas with hyperthyroidism].
Although thyrotropin-secreting pituitary tumors are rather exceptional, the authors have studied 5 new cases from 1982 to 1988. This apparently growing pattern is due to a more accurate diagnosis because of new laboratory measurements: --Immunoradiometric assay (IRMA) of ultra-sensitive thyrotropin (TSH); --Radioimmunoassay (RIA) of free alpha subunit of TSH; --Molar ratio of free alpha subunit/TSH before and after TRH stimulation; --Morphologic assessment of pituitary adenoma by computed tomographic scanning and nuclear magnetic resonance imaging; --Characterization of thyrotropin-secreting cells by immunohistochemical technics and identification of secretion products in cultured cells. The authors illustrate these new topics with a case report harboring a partial resistance to thyroid hormones. A 6-month treatment with somatostatin analogue (SMS 201.995) is reported, before transphenoidal ablation of the adenoma.
M
M
Linquette
J P
JP
Cappoen
M
M
Mazzuca
D000236:Adenoma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D000328:Adult; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology*; D008297:Male; D015282:Octreotide / Q000627:therapeutic use; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D013972:Thyrotropin / Q000378:metabolism*
D013972:Thyrotropin; D015282:Octreotide
Eléments nouveaux dans le diagnostic et le traitement des adénomes hypophysaires thyréotropes avec hyperthyroïdie.