Effect of left ventricular volume on right ventricular end-systolic pressure-volume relation. Resetting of regional preload in right ventricular free wall.
Effect of left ventricular (LV) volume on right ventricular (RV) end-systolic pressure-volume relation (ESPVR) was investigated, and the mechanism was examined from a standpoint of the alteration of RV free wall mean fiber length. Twelve cross-circulated isovolumically contracting canine hearts in which both ventricular volumes were controlled independently were used, and RV-ESPVR was determined at three different LV volume levels. At small (10.2 +/- 0.6 ml), middle (15.3 +/- 1.0 ml), and large (20.5 +/- 1.4 ml) LV volume, the slope of the RV-ESPVR was 2.63 +/- 0.13, 2.74 +/- 0.13, and 2.89 +/- 0.12 mm Hg/ml, respectively, and each value was significantly different from the others (p less than 0.01). The volume intercept (V0) of the relation (RV-V0) was significantly decreased with the increment of LV volume (RV-V0 in small, middle, and large LV volume; 3.92 +/- 0.68, 3.39 +/- 0.67, and 2.87 +/- 0.71 ml, respectively; p less than 0.01). In nine hearts, RV free wall lengths in latitudinal and meridional direction were measured at three LV volume levels when RV volume was held constant (16.1 +/- 1.1 ml). RV latitudinal end-diastolic length was significantly augmented with increasing LV volume (latitudinal length in small, middle, and large LV volume; 9.68 +/- 0.55, 9.81 +/- 0.56, and 9.92 +/- 0.55 mm, respectively). RV meridional end-diastolic length also increased significantly with increasing LV volume.(ABSTRACT TRUNCATED AT 250 WORDS)
First Department of Internal Medicine, Yamagata University School of Medicine, Japan.
S
S
Yamaguchi
K
K
Tsuiki
H
H
Miyawaki
Y
Y
Tamada
I
I
Ohta
H
H
Sukekawa
M
M
Watanabe
T
T
Kobayashi
S
S
Yasui
D000818:Animals; D001794:Blood Pressure; D003326:Coronary Circulation; D003971:Diastole; D004285:Dogs; D006321:Heart / Q000502:physiology*; D006352:Heart Ventricles / Q000033:anatomy & histology; D066298:In Vitro Techniques; D008955:Models, Cardiovascular; D010477:Perfusion; D013599:Systole; D014465:Ultrasonics; D016276:Ventricular Function