Effects of dietary linoleic acid and gamma linolenic acid on platelets of patients with multiple sclerosis.
The effects of dietary evening primrose oil (rich in linoleic acid and gamma-linolenic acid) were studied on platelets of multiple sclerosis (MS) patients and controls. It was found that platelet aggregation (ADP, thrombin and collagen), platelet fibrinogen binding and platelet glycoprotein (sialic acid and N-acetyl glucosamine) content were not significantly modified by evening primrose oil in MS patients and controls. Moreover, platelet fibrinogen binding and platelet glycoprotein (sialic acid and N-acetyl glucosamine) content were determined for the first time in MS patients and found similar to controls. Platelets of MS patients aggregated more to thrombin and collagen compared to controls, but the difference was only significant with thrombin aggregation after the oil treatment. This study does not show a significant effect of evening primrose oil on platelets of MS patients.
Mcgregor
L
L
Inserm Unit 63, Alexis Carrel Medical School, Lyon, France.
Smith
A D
AD
Sidey
M
M
Belin
J
J
Zilkha
K J
KJ
McGregor
J L
JL
D015126:8,11,14-Eicosatrienoic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood / Q000178:diet therapy* / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects*
D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D019787:Linoleic Acid; D015126:8,11,14-Eicosatrienoic Acid