[Immunocytochemical studies in the diagnosis of pulmonary histiocytosis X].
The diagnostic value of immunocytochemical tests was analysed for 19 cases of pulmonary histiocytosis X (PHX) and eight of other types of fibrosing pulmonary disease (sarcoidosis, 3; exogenous allergic alveolitis, 3; chronic pneumonia, 1; fibrosing alveolitis, 1). The cellular, proliferative-fibroblastic and fibrocystic stages in the course of pulmonary changes were differentiated. PHX cells reacted with anti-S 100 protein in all stages. In three cases for which unfixed tissue was available, all PHX cells reacted with antibody Leu-6, and 35% of these cells also reacted with the proliferation marker Ki-67. The few S-100 positive cells from the eight controls were limited to peribronchial tissue. Thus the antibodies Leu-6 and S-100 are useful aids in the diagnosis of PHX.
Institut für Pathologische Anatomie der Universität Wien.
O M
OM
Braun
P
P
Dalquen
W
W
Popp
B
B
Neumeister
N
N
Neuhold
N
N
Vetter
K
K
Krisch
D000906:Antibodies / Q000032:analysis; D000911:Antibodies, Monoclonal; D003937:Diagnosis, Differential; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000378:metabolism / Q000648:ultrastructure; D008171:Lung Diseases / Q000175:diagnosis* / Q000473:pathology; D008854:Microscopy, Electron; D011658:Pulmonary Fibrosis / Q000175:diagnosis / Q000473:pathology; D009418:S100 Proteins / Q000276:immunology; D012507:Sarcoidosis / Q000175:diagnosis / Q000473:pathology
D000906:Antibodies; D000911:Antibodies, Monoclonal; D009418:S100 Proteins
Immunzytochemische Untersuchungen in der Diagnostik der pulmonalen Histiocytosis X.