The effect of endotoxin on nociception in mice.
The possible antinociceptive activity of endotoxin was studied in mice. The antinociceptive properties of endotoxin (0.0003, 0.003, 0.03, 0.3 and 3 mg/kg, i.p.) were evaluated using the phenylbenzoquinone-induced writhing test. The antinociceptive activity of endotoxin was more potent than that of aminopyrine and morphine.
Department of Toxicology and Pharmacology, Cancer Research Institute, Tohoku College of Pharmacy, Sendai, Japan.
M
M
Ishikawa
S
S
Sugawara
Y
Y
Takayanagi
K
K
Sasaki
D000818:Animals; D000983:Antipyrine / Q000494:pharmacology; D016227:Benzoquinones; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D011809:Quinones; D013997:Time Factors
D016227:Benzoquinones; D004731:Endotoxins; D011809:Quinones; C029322:phenylbenzoquinone; D009020:Morphine; D000983:Antipyrine