Enzymes of oxidant defence system of leucocytes and erythrocytes in bovine anaplasmosis.
The glutathione oxidant defence system in leucocytes and erythrocytes of six Anaplasma marginale-infected calves was examined by assaying glutathione peroxidase (GSH-px), glutathione reductase (GSSG-R), reduced glutathione (GSH) and superoxide dismutase (SOD). In addition, GSH-S-transferase and arginase levels were measured in leucocytes. There was a significant decline in the activities of leucocyte GSH-px, GSSG-R and SOD in the post-patent period; whereas arginase activity rose significantly following the patent period of anaplasmosis. The activity of erythrocyte SOD declined in the post-patent stage. The infection also caused a decline in red cell GSH (P less than 0.05). The results suggest that the glutathione oxidant defence system of peripheral blood cells is significantly influenced by the Anaplasma infection.
Division of Biochemistry and Food Science, Indian Veterinary Research Institute, U.P., India.
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Reddy
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Sharma
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Singh
D000712:Anaplasmosis / Q000201:enzymology* / Q000276:immunology; D000818:Animals; D001119:Arginase / Q000097:blood; D002417:Cattle; D002418:Cattle Diseases / Q000201:enzymology* / Q000276:immunology; D004912:Erythrocytes / Q000201:enzymology*; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D007962:Leukocytes / Q000201:enzymology*; D008297:Male; D010084:Oxidation-Reduction; D013482:Superoxide Dismutase / Q000097:blood
D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D001119:Arginase; D005978:Glutathione