The ultrastructural picture of cerebral cortex of rat after hypoxia. I. Findings after inhalation of 5% O2 and 95% N2.
The ultrastructure of some elements in the motor region of the cerebral cortex of the rat were studied after hypoxia. The experimental animals, after receiving intraperitoneal chloral hydrate anaesthesia, were placed in a chamber with a controlled supply of a mixture of 95% N2 and 5% O2. After 2- and 3-hour exposure to hypoxic conditions the animals were processed for electron optic study. Edematous mitochondria pith partial or total destruction of the mitochondrial matrix were observed. Some mitochondria were changed into large vacuolar formations. The granular endoplasmic reticulum of neurocytes was dilated and in the broad dilatation structures of lamellar shape were sporadically found. The Golgi complex contained vacuoles of different sizes and long cisterns. Hydrated astrocytes were visualized in the neuropil and perivascular astrocyte processes displayed edematous changes. In the group of animals exposed to hypoxia for 3 hours but processed only 24 hours after termination of hypoxia the same changes were observed yet their extent was considerably diminished. This finding indicates that changes induced by hypoxia tend to return to normal conditions.
Remis
T
T
Benuska
J
J
Binovský
A
A
Masárová
M
M
D000818:Animals; D004195:Disease Models, Animal; D000860:Hypoxia / Q000473:pathology*; D008854:Microscopy, Electron; D009044:Motor Cortex / Q000648:ultrastructure*; D051381:Rats