Antidepressant effect of lithium: a neurochemical study on neuronal uptake of norepinephrine and serotonin.
1. The effect of lithium chloride on neuronal uptake of norepinephrine and serotonin was explored on a pure culture of chicken neurons. While an acute lithium treatment (25 minutes) proves ineffective, a long-term treatment (7 days) decreases the uptake of serotonin and increases the uptake of norepinephrine. 2. The combined administration of lithium (7 days) and clomipramine (25 minutes) appears to have a greater effect on the uptake of serotonin than a treatment limited to only one of the two products. 3. The clinical implications of these results are discussed while emphasizing the interest of lithium in the treatment of depression.
Wolf
M A
MA
Centre de Neurochimie du CNRS, Strasbourg, France.
Louis
J C
JC
Vincendon
G
G
D000818:Animals; D000928:Antidepressive Agents; D002478:Cells, Cultured; D002642:Chick Embryo; D002997:Clomipramine / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
D000928:Antidepressive Agents; D012701:Serotonin; D008094:Lithium; D002997:Clomipramine; D009638:Norepinephrine