Study of the disposition kinetics of the N-oxide-derivative: a metabolite of picobenzide.
The disposition kinetics of the N-oxide of picobenzide were studied after administration to rabbits at a bolus dose of 30 mg/kg of picobenzide intravenously. The biotransformation process fits a first-order kinetic process, and the metabolite shows good access capacity to the peripheral compartment. The N-oxide of picobenzide was determined by D.P.P. and parametric estimation was performed by the SIMPLEX method as the search algorithm.
Santos Buelga
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Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Salamanca, Spain.
Mariño
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EL
Domínguez-Gil
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A
D000818:Animals; D001549:Benzamides / Q000493:pharmacokinetics*; D001711:Biotransformation; D007202:Indicators and Reagents; D007275:Injections, Intravenous; D008954:Models, Biological; D011048:Polarography; D011817:Rabbits
D001549:Benzamides; D007202:Indicators and Reagents; C024323:picobenzide N-oxide; C016938:picobenzide