Further investigations of the defective protein C in hemodialysis, hemofiltration and continuous ambulatory peritoneal dialysis.
Protein C activity was determined in patients with terminal renal failure treated in three different ways: hemodialysis (n = 20), hemofiltration (n = 7) and continuous ambulatory peritoneal dialysis (n = 7). The protein C activity was decreased in terminal uremia, independent of the kidney replacement therapy employed, compared with 21 normal controls. In the hemodialysis patients protein C activity increased significantly during a hemodialysis treatment, whereas hemofiltration treatment normalized the depressed protein C activity. In vitro experiments with dialysis and with inhibition of normal plasma with ultrafiltrates could not reveal the presence of an inhibitor of protein C in uremic plasma.
Department of Medicine, Aalborg Hospital, Denmark.
P J
PJ
Sørensen
A H
AH
Nielsen
F
F
Knudsen
J
J
Dyerberg
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006440:Hemofiltration; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011486:Protein C / Q000378:metabolism*; D006435:Renal Dialysis
D011486:Protein C