Deferoxamine test and bone disease in dialysis patients with mild aluminum accumulation.
Aluminum bone disease is a frequent complication of dialysis patients. The deferoxamine (DFO) test has been advocated as a noninvasive procedure for the diagnosis of AI bone lesion. However most of these studies have been performed in symptomatic patients with significant AI bone disease. Whether this test may provide similar data at an earlier stage of AI toxicity is not known. The present study evaluates prospectively 28 patients with mild AI load. Patients studied ranged in age from 21 to 65 years; duration of dialysis was 5.6 +/- 3.2 years; deferoxamine, 40 mg/kg body weight, was infused at the end of dialysis. Serum AI was measured before DFO administration and before the next dialysis treatment. Bone biopsies were performed in all patients. Cortical bone AI was determined biochemically; trabecular and cortical bone AI were also determined histochemically. Mean basal serum AI (43.2 +/- 30.8 micrograms/L) and cortical bone AI (25.7 +/- 35.2 micrograms/g) were moderately increased. Basal serum AI correlated (r = 0.77) with the increment in serum AI after DFO infusion. After DFO, stainable trabecular and cortical bone AI correlated in a similar manner with both basal serum AI and increment in serum AI. Only biochemically determined cortical bone AI was not significantly related to basal serum AI. Nineteen of the 28 patients had evidence of osteitis fibrosa on bone biopsy. Stained AI surfaces but not trabecular AI were different in patients with low and patients with high bone formation rates. The bone findings, assessed as bone formation rates and resorption surfaces, did not correlate with biochemically or histochemically determined bone AI.(ABSTRACT TRUNCATED AT 250 WORDS)
INSERM U18, Hôpital Lariboisière, Paris.
M C
MC
de Vernejoul
S
S
Marchais
G
G
London
J
J
Bielakoff
P
P
Chappuis
C
C
Morieux
F
F
Llach
D000535:Aluminum / Q000009:adverse effects* / Q000378:metabolism; D001706:Biopsy; D001842:Bone and Bones / Q000473:pathology; D003676:Deferoxamine; D003956:Dialysis; D006801:Humans; D010018:Osteomalacia / Q000139:chemically induced* / Q000175:diagnosis; D011446:Prospective Studies; D013997:Time Factors
D000535:Aluminum; D003676:Deferoxamine