[Morphologic changes of the nucleolar system of lymphocytes as the indicator of sensitivity to tuberculin and Toxoplasma antigen].
A study was made of the nucleolar apparatus of peripheral blood lymphocytes of the newborns, infants and their mothers before and after incubation in vitro with tuberculin or toxoplasmic antigen. It was established that in the presence of sensitization to one or another antigen, there was an increase in the relative count of lymphocytes having a zone of clarification near nucleoli. In children vaccinated with BCG, such an effect was noted in 81.3% of the cases, whereas in children with verified toxoplasmosis, in all the cases. It is recommended that the method designed might be used as alternative for the complement fixation test in the diagnosis of toxoplasmosis.
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Gavrilova
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Autenshlius
D000818:Animals; D000953:Antigens, Protozoan / Q000032:analysis*; D002466:Cell Nucleolus / Q000648:ultrastructure*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis; D066298:In Vitro Techniques; D007223:Infant; D007231:Infant, Newborn; D008214:Lymphocytes / Q000648:ultrastructure*; D014122:Toxoplasma / Q000276:immunology*; D014126:Toxoplasmosis, Ocular / Q000097:blood* / Q000151:congenital / Q000276:immunology; D014373:Tuberculin / Q000276:immunology*; D014605:Uveitis / Q000097:blood* / Q000151:congenital / Q000276:immunology
D000953:Antigens, Protozoan; D014373:Tuberculin
Morfologicheskie izmeneniia nukleoliarnogo apparata limfotsitov kak ppkazate'l chuvstvite'lnosti k tuberkulinu i toksoplazmen- nomu antigenu.