Glycaemic control affects cellular sodium metabolism.
Total and amiloride sensitive leucocyte sodium influx in Media containing 10 mmol/l Na was studied directly using a triple isotope method for measuring initial 22Na uptake rates in 25 non insulin dependent diabetic subjects. Glycaemic control was assessed by glycated haemoglobin and fasting blood glucose. Although no significant relationship between Na flux and either plasma insulin or blood glucose could be found, glycated haemoglobin was significantly correlated with both total and amiloride sensitive flux. Glycaemic control must be considered in future work on cellular sodium metabolism.
Sheikh Rashid Diabetes Unit, Radcliffe Infirmary, Oxford, UK.
D
D
Simmons
L L
LL
Ng
M
M
Harker
T D
TD
Hockaday
D000584:Amiloride / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000097:blood*
D000584:Amiloride; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D012964:Sodium