Biliary and pancreatic excretion of cefamandole.
After intravenous infusion of secretin and cholecystokinin in six dogs, cefamandole (50 mg/kg of body weight) was given intravenously for 10 min. Samples of serum, bile, pancreatic juice, liver, pancreas, fat, and muscle were collected over a 2-h period. Cefamandole levels were measured by a microbiological assay. The highest levels were as follows: serum, 160 micrograms/ml; bile, 3,071 micrograms/ml; pancreatic juice, 7 micrograms/ml; liver, 101 micrograms/g; pancreas, 44 micrograms/g; muscle, 20 micrograms/g; and fat, 14 micrograms/g. Levels in pancreatic juice were extremely low compared with levels in pancreatic tissue, suggesting the existence of a barrier to excretion at the ductal membrane.
Department of Surgery, Long Island Jewish Medical Center, New Hyde Park, New York 11042.
G P
GP
Burns
T A
TA
Stein
M
M
Cohen
D000818:Animals; D001646:Bile / Q000378:metabolism*; D002435:Cefamandole / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004285:Dogs; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism*
D002435:Cefamandole