The influence of the convulsant pentylenetetrazol on Ca2+-selective microelectrodes (neutral carrier ETH 1001).
Interference of the epileptogenic drug pentylenetetrazol (PTZ) on the Ca2+-selective microelectrode based on the neutral carrier ETH 1001 is described. It is suggested that tetraphenylborate, a component of the Ca2+-selective membrane, is responsible for this interference. Though the sensitivity of the Ca2+-selective microelectrode to PTZ is low, the error in measurements of the free Ca2+ concentration in biological preparations treated with PTZ has to be considered, since pathological changes in the extracellular Ca2+ concentration also produce relatively small changes in the relative electrode potential.
Lücke
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Institute of Physiology, University of Münster, F.R.G.
Lehmenkühler
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A
Speckmann
E J
EJ
D000818:Animals; D002118:Calcium / Q000502:physiology*; D008839:Microelectrodes; D010433:Pentylenetetrazole / Q000494:pharmacology*
D002118:Calcium; D010433:Pentylenetetrazole