Dopamine and preparatory behavior: III. Effects of metoclopramide and thioridazine.
The effects of metoclopramide and thioridazine on feeding behaviors of male hooded rats were investigated in 2 experiments. Metoclopramide (2.5-7.5 mg/kg) attenuated conditioned preparatory responses to a conditional stimulus signaling delivery of a meal. However, consummatory responses were affected only by the highest dose. Similar effects had previously been observed following administration of pimozide (Blackburn, Phillips, & Fibiger, 1987). Thioridazine (10-30 mg/kg) had no significant effect on any measure of feeding behavior. The different effects of the 2 drugs may be related to their preferential actions at dopamine terminals in anatomically distinct regions of the forebrain.
University of British Columbia, Vancouver, Canada.
J R
JR
Blackburn
A G
AG
Phillips
H C
HC
Fibiger
D000818:Animals; D001143:Arousal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects; D004298:Dopamine / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D009042:Motivation / Q000187:drug effects*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D013881:Thioridazine / Q000494:pharmacology*
D011954:Receptors, Dopamine; D008787:Metoclopramide; D013881:Thioridazine; D004298:Dopamine