Immune function in the elderly.
Normal aging is accompanied by diverse changes in the immune system. Altered function of both T- and B-cells can be shown by losses in proliferative ability and interleukin-2 and interferon synthesis. Granulocyte function is decreased. Although there can be elevations in immunoprotein levels, antibody formation is decreased in most elderly individuals. Response to immunization varies greatly in the aged. This paper discusses the changes in immune function in the elderly, and the clinical implications of these changes.
Clinical Immunology Section, National Institute on Aging, Baltimore, Maryland.
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Adler
D000368:Aged; D000375:Aging / Q000276:immunology*; D000917:Antibody Formation; D006098:Granulocytes / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007109:Immunity; D007958:Leukocyte Count; D008214:Lymphocytes; D008875:Middle Aged