Control of sweating during the human menstrual cycle.
Thermoregulatory responses were studied in seven women during two separate experimental protocols in the follicular (F, days 4-7) phase and during the luteal (L, days 19-22) phase of the menstrual cycle. Continuous measurements of esophageal temperature (Tes), mean skin temperature (Tsk), oxygen uptake and forearm sweating (ms) were made during all experiments. Protocol I involved both passive heat exposure (3 h) and cycle exercise at approximately 80% VO2 peak during which the environmental chamber was controlled at Ta = 50.0 degrees C, rh = 14% (Pw = 1.7 kPa). In protocol II subjects were tested during thirty-five minutes of exercise at approximately 85% VO2 peak at Ta = 35 degrees C and rh = 25% (Pw = 1.4 kPa). The normal L increase in resting Tes (approximately 0.3 degrees C) occurred in all seven subjects. Tsk was higher during L than F in all experiments conducted at 50 degrees C. During exercise and passive heat exposure, the Tes threshold for sweating was higher in L, with no change in the thermosensitivity (slope) of ms to Tes between menstrual cycle phases. This rightward or upward shift in Tes threshold for initiation of sweating averaged 0.5 degrees C for all experiments. The data indicate the luteal phase modulation in the control of sweating in healthy women is also apparent during severe exercise and/or heat stress.
US Army Research Institute of Environmental Medicine, Natick, MA 01760-5007.
M A
MA
Kolka
L A
LA
Stephenson
D000328:Adult; D001831:Body Temperature; D001833:Body Temperature Regulation; D001835:Body Weight; D004837:Epinephrine / Q000097:blood; D015444:Exercise; D005080:Exercise Test; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008597:Menstrual Cycle; D009638:Norepinephrine / Q000097:blood; D010101:Oxygen Consumption; D012881:Skin Temperature; D013312:Stress, Physiological / Q000378:metabolism; D013546:Sweating
D009638:Norepinephrine; D004837:Epinephrine