[Use of a cream based on 20% azelaic acid in the treatment of melasma].
A 20% azelaic acid base cream (Skinoren-Schering) known in the treatment of acne has been used in melasma. The statistically processed results refer to 39 patients treated for 6 months with 2 applications/die. The reduction in melasma intensity was obtained in all patients bar two whose basal pigmentation situation was already compromised. Overall assessment on a graduated scale in cm evidences, after 6 months of treatment, a mean reduction in pigmentation of 51.3% understood as intensity and surface. The overall judgment of physician and patient on the preparation coincide with some 79% excellent and good on the part of the physician and 85% on the part of the patient. Noteworthy is the absolute absence of sensitisation or leukoderma or any of the other typical side-effects of the other depigmentants available thus far.
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D000328:Adult; D000368:Aged; D003998:Dicarboxylic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008548:Melanosis / Q000188:drug therapy*; D008875:Middle Aged; D009824:Ointments
D003998:Dicarboxylic Acids; D009824:Ointments; C010038:azelaic acid
Impiego di una crema a base di acido azelaico 20% nel trattamento del melasma.