Long term pathological sequelae of neonatal endotracheal intubation.
In neonates, acquired subglottic stenosis (SGS) is the most serious long term complication of endotracheal intubation. In this case report, we describe the pathological changes in the larynx of a child who died two years after successful treatment, involving corrective surgery, for neonatally acquired SGS. Stenosis, due to dense fibrous connective tissue, was still present at death. However, there was evidence that there had been growth of the laryngeal cartilages. Disruption of the laryngeal cartilages was present anteriorly due to the antecedent surgery but major cricoid cartilage injury secondary to intubation was not seen. The crico-arytenoid joints demonstrated ankylosis and to this was attributed the abnormal quality of voice noted in the child at follow-up. The pathological changes are considered in relation to the pathology of endotracheal intubation and pathogenesis of acquired subglottic stenosis.
Department of Histopathology, University College and Middlesex School of Medicine, London.
S J
SJ
Gould
J
J
Graham
D006801:Humans; D006819:Hyaline Membrane Disease / Q000628:therapy; D007231:Infant, Newborn; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007829:Laryngostenosis / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D007830:Larynx / Q000473:pathology / Q000601:surgery; D008297:Male; D013997:Time Factors