[HLA antigens in type II diabetics].
The study examined the relationship between class I HLA antigens and type II diabetes with regard to insulin secretion and hyperlipoproteinemia. Out of 28 HLA antigens of A, B and C loci, 46 type II diabetics had statistically more significant HLA Cw1 - 15.9% as compared with 6.3% of the control group, the relative risk being 2.81. These patients were younger than the other diabetics but showed no difference in insulin secretion or hyperlipoproteinemia. Diabetics with HLA Cw4, just as patients after myocardial infarction with concomitant hyperlipoproteinemia, were also found frequently to have hyperlipoproteinemia (89 percentage cases as compared to 63% of the other diabetics). The findings may be indicative of potential genetic heterogeneity of type II diabetes. The paper stresses the necessity of establishing suitable genetic characters for early diagnosis of diabetes and its development.
Jirkovská
A
A
Ivasková
E
E
Válek
J
J
Skibová
J
J
Grafnetter
D
D
Petrásek
R
R
D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens
HLA antigeny u diabetiků II. typu.