Secretory pattern of growth hormone regulates steroid sulfatase activity in rat liver.
Steroid sulfatase activity was quantified in liver microsomes from hypophysectomized adult female rats treated with estradiol and continuous or intermittent human growth hormone (hGH). Hypophysectomy clearly enhanced sulfatase activity as compared to intact female rats. Normal female values were completely restored by continuous infusion of hGH (1.4 i.u./kg/day). Neither the same dose of hGH given as two daily injections nor estrogen replacement therapy had any effect. It is concluded that liver microsome sulfatase activity in the non-pregnant rat is regulated by the sexually dimorphic secretory pattern of GH.
Department of Obstetrics and Gynecology, University Hospital, Umeå, Sweden.
L
L
Eriksson
B
B
Nilsson
K
K
Carlström
J
J
Oscarsson
S
S
Eden
B
B
von Schoultz
D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D013006:Growth Hormone / Q000008:administration & dosage / Q000378:metabolism / Q000502:physiology*; D007016:Hypophysectomy; D007260:Infusion Pumps; D007279:Injections, Subcutaneous; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000378:metabolism*
D004958:Estradiol; D013006:Growth Hormone; D013429:Sulfatases; D001192:Arylsulfatases; D043266:Steryl-Sulfatase