[Identification of trihalomethanes in drinking water and assessment of their toxicity, mutagenicity and carcinogenicity].
Dichlorobromomethane (DCMB) and dibromochloromethane (DBCM) isolated from chlorinated drinking water were tested for toxicity, mutagenicity and carcinogenicity. Both agents proved mutagenic in a "dessicator" modification of the Ames test using Salmonella typhimurium TA98 and TA100 in the presence of exogenous metabolic activation. In aquarium Danio rerio fish tests, LD50/30 was 250 mg/l for both compounds. Both agents induced hepatocellular carcinoma in fish: DCMB--in 11 out of 29 animals (at 16.5 weeks) and DBCM--in 3 out of 16 (at 26.5 weeks). These data merit further investigation of the agents' carcinogenicity in chronic experiments in rodents.
Khudoleĭ
V V
VV
Gvil'dis
V Iu
VIu
Pliss
G B
GB
D000818:Animals; D015197:Carcinogenicity Tests; D005393:Fish Diseases / Q000139:chemically induced; D005399:Fishes; D006846:Hydrocarbons, Halogenated / Q000302:isolation & purification* / Q000633:toxicity; D008113:Liver Neoplasms / Q000139:chemically induced; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D009152:Mutagenicity Tests; D051381:Rats; D022882:Trihalomethanes; D014881:Water Supply / Q000032:analysis*
D006846:Hydrocarbons, Halogenated; D022882:Trihalomethanes; C032707:chlorodibromomethane; C025191:bromodichloromethane
Identifikatsiia v pit'evoĭ vode nekotorykh trigalometanov i vyiavlenie ikh toksichnosti, mutagennosti i kantserogennosti.