[Effects of thermal burns of the esophagus on carcinogenesis induced by ethyl ethers of N-nitrososarcosine in rats].
The study was concerned with the effect of electro-thermocoagulation burn of the rat gullet on carcinogenesis induced by esophagotropic carcinogen--ethyl ester of N-nitrososarcosine (50 mg/kg, five times a week, four months). Treatment was started on day 15 postburn, and at 8 months tumors of the esophagus occurred in 71.8% including tumors in the burn area (46.8%). Forestomach neoplasms were observed in 15.6%. Animals treated with the carcinogen alone showed a significant decrease in both overall frequency of esophageal tumors (42.4%) and that for the burn area (18.1%) while frequency of forestomach neoplasia remained nearly the same (21.2%). Most tumors were benign papillomas. It was concluded that burn--induced cicatricial changes in the esophageal mucosa predispose to development and growth of tumors of this site.
Novikov
A I
AI
Aleksandrov
V A
VA
Zabezhinskiĭ
M A
MA
Stoliarov
V I
VI
D000818:Animals; D002056:Burns / Q000150:complications*; D002921:Cicatrix / Q000150:complications; D004564:Electrocoagulation; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000209:etiology*; D004947:Esophagus / Q000293:injuries*; D005019:Ethyl Ethers / Q000008:administration & dosage; D006358:Hot Temperature; D009602:Nitrosamines / Q000008:administration & dosage; D010212:Papilloma / Q000139:chemically induced / Q000209:etiology*; D051381:Rats; D013997:Time Factors
D005019:Ethyl Ethers; D009602:Nitrosamines; C013162:N-nitrososarcosine
Vliianie termicheskogo ozhoga pishchevoda na kantserogenez, vyzyvaemyĭ étilovym éfirom N-nitrozosarkozina u krys.