[The local cooling effect of anterior chamber irrigation on the blood-aqueous barrier].
Local cooling effect on the breakdown of the blood-aqueous barrier (BAB) following anterior chamber irrigation, including additional direct irritation of the iris, was evaluated fluorophotometrically. The rabbit anterior chamber was irrigated with simulated aqueous humor (S-MA 2) the temperature of which was maintained at 35 degrees C or 10 degrees C. The fluorophotometry was performed before and 4, 24, 48 hours and 7 days after irrigation for 30 or 60 minutes. The temperature changes in the anterior chamber, retrolental vitreous body and posterior retina were also measured with a thermocouple during irrigation at 10 degrees C. The temperature of the anterior chamber and the retrolental vitreous fell to 15.0 degrees C and 28.2 degrees C, respectively, within 30 minutes after starting irrigation, whereas the temperature drop in the posterior retina was only 2.0 degrees C after 60 min. At 4 hours after 60-minute irrigation, the breakdown of the BAB was greater than following 30-minute irrigation. There was no significant difference in the BAB breakdown between eyes irrigated at 10 degrees C and 35 degrees C.
Honda
F
F
Majima
A
A
Tamai
K
K
D000818:Animals; D000867:Anterior Chamber; D001082:Aqueous Humor / Q000378:metabolism*; D001831:Body Temperature; D005452:Fluoresceins / Q000493:pharmacokinetics; D007036:Hypothermia, Induced; D011817:Rabbits; D007507:Therapeutic Irrigation; D013997:Time Factors
D005452:Fluoresceins