[Treatment of reflex algoneurodystrophies by sympathetic blockade with guanethidine].
Reflex sympathetic dystrophy (RSD) can be treated by regional sympathetic blockade with guanethidine. This method was used systematically in 25 patients with post-traumatic RSD of the upper (n = 8) or lower limb (n = 17). Sixty three blocks were performed, each patient receiving 1 to 4 blocks. The results were appreciated by the effects after one month on pain, mobility and trophic changes. They were excellent in 7 cases, good in 4 cases and poor in 7 cases. The results were better in moderate RSD without psychiatric overlay. Thirteen patients were cured after 3 months. Pain decreased significantly 2 days after injection in 28 of the 63 blocks. The effects on mobility and trophic changes always occurred after the analgesic effect. No side effects were observed with the exception of one patient who had a convulsion 2 hours after the injection. These results show that regional sympathetic blockage with guanethidine is useful for the treatment of RSD, especially in its moderate stages. In view of the negligible risks and its efficacy, the authors consider it to be the first line treatment of moderate RSD.
Service de Rhumatologie, HIA Laveran, impasse des Lauriers, Marseille Armées.
P
P
Jeandel
D
D
Prigent
B
B
Gilette
P
P
Imbert
G
G
Angel
M
M
Aubert
D000328:Adult; D000368:Aged; D005260:Female; D006145:Guanethidine; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009407:Nerve Block / Q000379:methods*; D012019:Reflex Sympathetic Dystrophy / Q000188:drug therapy*; D013997:Time Factors
D006145:Guanethidine
Traitement des algoneurodystrophies réflexes par blocs sympathiques à la guanéthidine.