[Clinical and morphologic aspects of benign bone tumors and tumorous bone lesions. Follow-up, therapy and prognosis].
In this study, a total of 1434 benign bone tumors and 384 tumor-like bone lesions that have been diagnosed from 1945 until 1974 in the Institute of Pathology of the University of Freiburg was reviewed and statistically analysed. The most frequent tumors include 720 osteochondromas, 345 enchondromas and 93 osteomas (80.8%). The remainder of 276 cases included several tumorous bone lesions with an individual share of below 5%. Our 64 osteoclastomas (4.5%) are in reality tumors of low grade of malignancy. There was an equal distribution among both sexes (737 male, 695 female). Predominate location were the bones of extremities and the skull. Most often, we have found these tumors in the lower legs, and one third was localized in hands and feet. 60% of the benign bone tumors of the hands have been enchondromas. Osteomas and hemangiomas have been localized most often in the skull, and ossifying and non-ossifying fibromas in the jaws. Main localization of osteoclastomas was the knee. Roentgenograms have always been put into consideration for diagnoses and have, together with the histological findings, facilitate an exact classification. Clinical findings have only exceptionally shown indicative symptoms (e. g. night pain in cases of osteoid osteomas); otherwise there were vague swelling, pain or disfunction. Benign bone tumors are poor of symptoms. Concerning therapy, most bone tumors have been cured by operation (curettage, excision). In some tumors (especially in chondromyxoidfibromas) recurrences have occurred. No investigated bone tumor has shown a malignant transformation.
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Adler
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Brendle
D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology; D002812:Chondroma / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005870:Giant Cell Tumors / Q000473:pathology*; D006801:Humans; D008297:Male
Klinische und morphologische Aspekte von gutartigen Knochentumoren und tumorähnlichen Knochenläsionen. Verlauf, Therapie und Prognose.