[Immunologic and immunogenetic heterogeneity of systemic and discoid lupus erythematosus].
The immune and endocrine systems and HLA genotype were subjected to a comparative study in patients with systemic and discoid lupus erythematosus (SLE, DLE). The patients suffering from these diseases were found to differ in a number of the parameters of the immune status including the content in blood serum and supernatant of the cultivated mononuclear cells of the soluble molecules HLA-A, HLA-B and HLA-DR. The degree of the SLE and DLE association with the genes and haplotypes of class I HLA complex was different as was the character of the association of HLA-A and HLA-B specificities with the activity of the immune system cells and with hydrocortisone content in plasma. The common immunogenetic syndrome characteristic of SLE and DLE patients has been identified.
Konenkov
V I
VI
Korotkova
I Iu
IIu
Prokof'ev
V F
VF
Petrova
E M
EM
Lozovoĭ
V P
VP
D000293:Adolescent; D000328:Adult; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D006680:HLA Antigens
Immunologicheskaia i immunogeneticheskaia raznorodnost' sistemnoĭ i diskoidnoĭ krasnoĭ volchanki.