Appearance of a transient inv(14)(q11q32) in a case of B cell chronic lymphocytic leukemia.
The inv(14)(q11q32) has been reported to be a specific chromosome aberration in T-cell chronic lymphocytic leukemia (T-CLL) and different types of T-cell lymphomas. Here, the first case of B-CLL with a clonal inv(14)(q11q32) in a phytohemagglutinin-stimulated bone marrow culture is presented. In a subsequent study 9 months later, tetradecanoyl-o-phorbol-13-acetate stimulated blood and bone marrow cultures revealed a clone with a t(1;11)(p13.2;q23.1) and an aberrant chromosome 17.
Department of Human Genetics, Christian Albrechts-Universität, Kiel, West Germany.
B
B
Schlegelberger
L
L
Zech
H
H
Euler
H
H
Löffler
A
A
Himmler
A
A
Feller
D000368:Aged; D002871:Chromosome Banding; D007446:Chromosome Inversion; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male