Caudato-nigral transmission in the substantia nigra pars reticulata neurons changes with recovery from circling movements induced by microinfusion of ibotenic acid. I. Behavioral study.
Following creation of a unilateral circumscribed lesion in a portion of a cat substantia nigra pars reticulata by microinfusion of ibotenic acid, circling movements toward the contralateral side of the lesion appeared within 2 days and disappeared a few days later. After recovery, the circling movements reappeared when the cats were decerebrated at the premammillary and precollicular level, suggesting that brain centers rostral to the decerebration participate in compensating the circling movements.
Division of Neuromuscular Skills, Faculty of Health and Sport Sciences, Osaka University, Japan.
M
M
Udo
T
T
Shimada
S
S
Hirose
H
H
Okamura
H
H
Yamamoto
D000818:Animals; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology*; D007051:Ibotenic Acid / Q000633:toxicity*; D009498:Neurotoxins / Q000494:pharmacology; D010080:Oxazoles / Q000633:toxicity*; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology*; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*
D009498:Neurotoxins; D010080:Oxazoles; D007051:Ibotenic Acid