Heat shock proteins as markers of neural injury.
Systemic or intracerebral injections of kainic acid induced immunoreactivity for the 72 kDa heat shock protein (HSP72) in individual neurons of the rat brain in patterns matching the known histopathology of the particular injury. HSP72 immunostaining was also induced in and around areas of infarction following experimental strokes. These results suggest that HSP72 immunocytochemistry may be used as a marker of cellular injury in the mammalian brain.
Department of Neurology, University of California, San Francisco.
M F
MF
Gonzalez
K
K
Shiraishi
K
K
Hisanaga
S M
SM
Sagar
M
M
Mandabach
F R
FR
Sharp
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000378:metabolism* / Q000473:pathology; D006360:Heat-Shock Proteins / Q000378:metabolism*; D007150:Immunohistochemistry; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D008970:Molecular Weight; D051381:Rats
D006360:Heat-Shock Proteins; D007608:Kainic Acid