Individual and combined toxicity of deoxynivalenol and T-2 toxin in broiler chicks.
Effects of feeding diets containing deoxynivalenol (DON)-contaminated wheat (16 mg DON/kg) and purified T-2 toxin at 4 mg/kg singly and in combination were characterized in male broiler chicks from 1 day to 3 wk of age. Total body weight gains and final body weights were significantly reduced by the DON/T-2 toxin combination but were not significantly affected by the toxins singly. The efficiency of feed utilization was reduced in chicks fed either of the diets containing DON-contaminated wheat. The incidence and severity of oral lesions induced by T-2 toxin was increased in the DON/T-2 toxin combination. Several parameters not altered by DON or T-2 toxin singly were significantly affected by the combination, indicating that the combination may pose a potentially greater problem to the poultry industry than either of the mycotoxins individually.
Kubena
L F
LF
USDA, Agricultural Research Service, College Station, Texas 77841.
Huff
W E
WE
Harvey
R B
RB
Phillips
T D
TD
Rottinghaus
G E
GE
D000821:Animal Feed / Q000032:analysis; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002060:Bursa of Fabricius / Q000187:drug effects; D002645:Chickens / Q000502:physiology*; D004338:Drug Combinations; D005895:Gizzard, Avian / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D012717:Sesquiterpenes / Q000633:toxicity*; D013605:T-2 Toxin / Q000633:toxicity*; D013997:Time Factors; D014255:Trichothecenes / Q000633:toxicity*
D004338:Drug Combinations; D012717:Sesquiterpenes; D014255:Trichothecenes; D013605:T-2 Toxin; C007262:deoxynivalenol