[1,4-Disubstituted 1,3-dihydro-2H-1,5-benzo- and chlorobenzodiazepin-2-ones with activity on the central nervous system].
In pursuing the study on pyridodiazepinone derivatives, in order to verify the variation of biological activity induced by replacement of the heteroaromatic with an aromatic nucleus and by the introduction of chlorine on the benzene ring, a series of 1-[(dialkylamino)alkyl]-4-phenyl-1,3-dihydro-2H-1,4-benzodiazepin- 2-ones and of 7-chloro-analogues were prepared. Some benzodiazepinones and their 7-chloro-analagous were subjected to pharmacological experimentation in order to evaluate and compare their effect upon mice with regard to exploratory activity, motor coordination and spontaneous motility. In addition their anti-strychnine, anti-cardiazole, anti-amphetamine and anti-reserpine activities were also evaluated.
Istituto di Scienze Farmaceutiche, Università di Genova.
F
F
Savelli
A
A
Boido
A
A
Mulè
L
L
Piu
M C
MC
Alamanni
G
G
Pirisino
M
M
Satta
A
A
Peana
D000662:Amphetamines / Q000037:antagonists & inhibitors; D000818:Animals; D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002492:Central Nervous System Depressants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D004347:Drug Interactions; D005106:Exploratory Behavior / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D012110:Reserpine / Q000037:antagonists & inhibitors
D000662:Amphetamines; D001570:Benzodiazepinones; D002492:Central Nervous System Depressants; D012110:Reserpine
1,3-diidro-2H-1,5-benzo- e -clorobenzodiazepin-2-oni-1,4-disostituiti ad attività sul S.N.C.