Are certain HLA haplotypes responsible for low testosterone levels in males?
The level of testosterone on 138 HLA typed healthy males and 71 male rheumatoid arthritis patients were analysed. HLA-B15 was associated with a lower mean serum testosterone level in males than any other tissue type. This was observed in both the normal and RA groups.
ARC Epidemiology Research Unit, University of Manchester, U.K.
W
W
Ollier
T
T
Spector
A
A
Silman
L
L
Perry
J
J
Ord
W
W
Thomson
H
H
Festenstein
D001172:Arthritis, Rheumatoid / Q000097:blood; D015235:HLA-B Antigens / Q000032:analysis*; D059910:HLA-B15 Antigen; D006239:Haplotypes; D006801:Humans; D008297:Male; D013739:Testosterone / Q000097:blood*
D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D013739:Testosterone