Metabolism of pentachlorophenol by fish.
1. Interspecies variability in the metabolism of pentachlorophenol (PCP) was investigated by exposing rainbow trout, fathead minnows, sheepshead minnow, firemouth, and goldfish to water-borne 14C-PCP for 64 h. 2. The amounts of metabolites in bile and exposure water were species-dependent; all of the metabolites excreted into the water were sulphate conjugates while bile was enriched in glucuronide conjugates. 3. Biliary excretion accounted for less than 30% of the total PCP metabolites. 4. Biliary metabolites alone were a poor indication of the metabolites produced and of the major routes of elimination.
Stehly
G R
GR
Pharmacology/Toxicology Program, Washington State University, Pullman 99164-6510.
Hayton
W L
WL
D000818:Animals; D001646:Bile / Q000378:metabolism; D002733:Chlorophenols / Q000493:pharmacokinetics*; D003530:Cyprinidae / Q000378:metabolism; D005399:Fishes / Q000378:metabolism*; D006054:Goldfish / Q000378:metabolism; D010416:Pentachlorophenol / Q000493:pharmacokinetics*; D013045:Species Specificity; D014018:Tissue Distribution; D014337:Trout / Q000378:metabolism; D014873:Water Pollutants / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000378:metabolism*
D002733:Chlorophenols; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D010416:Pentachlorophenol