[The effect of the calcium antagonists nimodipin, verapamil and diltiazem on local cerebral blood flow of the cortex and thalamus in cats].
Experiments were carried out on 54 cats, anesthesized by ether and alpha chloralose (0, 1 g/kg of b. m.) and the influence of calcium antagonists nimodipin (0.01 and 0.03 mg/kg), verapamil (0.1 and 0.3 mg/kg) and diltiazem (0.1 and 0.3 mg/kg), administered intravenously by a femoral venous catheter, was investigated on th local cerebral blood flow in the cortex and thalamus by means of a thermistor thermoclearance technique. The cerebral blood flow was recorded in the sensomotor area of the cortex-and pulvinar thalami. The effect of these drugs was examined on arterial blood pressure in dynamics synchronously. Calcium antagonist nimodipin, verapamil and diltiazem increased cerebral blood flow and this effect was more manifested in the cortex than in the thalamus. The effect of nimodipin was considerably stronger on the cerebral blood flow in the cortex in comparison with verapamil and diltiazem. Verapamil and diltiazem showed approximately equal effect on cerebral blood flow in the cortex. Diltiazem increased cerebral local blood flow, but not-that of the thalamus.
Ganchev
E
E
D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000098:blood supply* / Q000187:drug effects; D004110:Diltiazem / Q000494:pharmacology*; D009553:Nimodipine / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D013788:Thalamus / Q000098:blood supply* / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology*
D009553:Nimodipine; D014700:Verapamil; D004110:Diltiazem
Vliianie na kaltsievite antagonisti nimodipin, verapamil i diltiazem vŭrkhu localniia mozŭchen krŭvotok v kora i talamus na kotki.