The [lactate]/[pyruvate] ratio and alcohol metabolism: experiments with naloxone in fasting normal male volunteers.
Naloxone administration to fasting normal male volunteers reverses the acute ethanol-induced increase in the blood [lactate]/[pyruvate] ratio, but fails to lower blood-ethanol concentration. The results are discussed in relation to factors affecting ethanol elimination and the mechanism of antagonism of acute alcohol intoxication by naloxone.
South Glamorgan Health Authority, Biomedical Research Laboratory, Cardiff, Wales.
C J
CJ
Morgan
A A
AA
Badawy
D R
DR
Thomas
T G
TG
Dando
A
A
Kirby
D000328:Adult; D000435:Alcoholic Intoxication / Q000097:blood; D000431:Ethanol / Q000493:pharmacokinetics*; D006801:Humans; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood*; D019289:Pyruvic Acid
D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D009270:Naloxone; D000431:Ethanol; D019289:Pyruvic Acid