Methylprednisolone pulse therapy in severe dysthyroid optic neuropathy.
Five patients with severe dysthyroid optic neuropathy were treated with intravenous methylprednisolone (1 g daily for 3 consecutive days). Before administration, visual acuity of the more severely affected eyes of each patient was counting fingers at 5 feet, 8/200, 20/400, 20/200, and 20/80. Immediately after completion of pulse therapy, visual acuity improved to 20/25 in four patients and 20/30 in one. Remissions were maintained with oral prednisone and external beam irradiation of the orbit. Pulse methylprednisolone therapy appears to be beneficial in the initial management of severe dysthyroid optic neuropathy.
Guy
J R
JR
Department of Ophthalmology, University of Florida, College of Medicine, Gainesville 32610-0284.
Fagien
S
S
Donovan
J P
JP
Rubin
M L
ML
D000328:Adult; D005260:Female; D006111:Graves Disease / Q000188:drug therapy*; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage; D006973:Hypertension / Q000188:drug therapy; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D009915:Orbit / Q000528:radiation effects; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity; D014794:Visual Fields
D006852:Hydrochlorothiazide; D008775:Methylprednisolone