[Stereospecific hydroxylation of (+)-sparteine (pachycarpine) in the rat].
Pachycarpine (4), the optical antipode of the lupine alkaloid (-)-sparteine (1), has been prepared from (-)-lupanine; its metabolism was studied in rats. After isolation and chromatographic purification, streochemically homogeneous (+)-(4S)-hydroxysparteine (7) was identified as the major urinary metabolite by use of mass spectrometry and high-field NMR-spectroscopy.
Ebner
T
T
Eichelbaum
M
M
Fischer
P
P
Meese
C O
CO
D000818:Animals; D006900:Hydroxylation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013034:Sparteine / Q000378:metabolism*; D013237:Stereoisomerism
D013034:Sparteine
Uber die stereospezifische Hydroxylierung von (+)-Spartein (Pachycarpin) bei der Ratte.