Antiarrhythmic peptide has no direct cardiac actions.
The electrophysiologic, inotropic, and muscarinic effects of antiarrhythmic peptide (AAP) were examined in canine cardiac Purkinje fibers, ferret papillary muscle, and canine cardiac membranes, respectively. Aside from a prolongation of time to peak force in papillary muscle, no biologically significant effects of AAP could be determined in any preparation, suggesting that its antiarrhythmic effects are not mediated by direct membrane actions.
Argentieri
T
T
Berlex Laboratories, Inc., Cedar Knolls, New Jersey 07927.
Cantor
E
E
Wiggins
J R
JR
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D004285:Dogs; D004558:Electric Stimulation; D005289:Ferrets; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006329:Heart Conduction System / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*; D010210:Papillary Muscles / Q000187:drug effects* / Q000502:physiology; D011690:Purkinje Fibers / Q000187:drug effects* / Q000502:physiology; D011976:Receptors, Muscarinic / Q000187:drug effects; D013268:Stimulation, Chemical
D000889:Anti-Arrhythmia Agents; D009842:Oligopeptides; D011976:Receptors, Muscarinic; C029579:antiarrhythmic peptide