Synthesis and hypolipidemic activity of some new esters of glycerol and 2-O-methyl-glycerol with nicotinic and 5-fluoro-nicotinic acids.
A series of new esters of glycerol and 2-O-methyl-glycerol with nicotinic and 5-fluoro-nicotinic acids were synthesized and their hypolipidemic activities were comparatively tested. The two most interesting compounds, 5 and 12, show a higher activity than both nicotinic and 5-fluoro-nicotinic acids in the following experimental models: Triton and olive oil hyperdyslipemia and tests on old rats.
Dall'Asta
L
L
Comini
A
A
Borella
F
F
Berti
M A
MA
Coppi
G
G
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005995:Glyceryl Ethers / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000188:drug therapy; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D009539:Nicotinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D005995:Glyceryl Ethers; D000960:Hypolipidemic Agents; D009539:Nicotinic Acids