Hydroporphyrins of the meso-tetra(hydroxyphenyl)porphyrin series as tumour photosensitizers.
Four new hydroporphyrins [the o, m and p isomers of 5,10,15,20-tetra(hydroxyphenyl)chlorin and 5,10,15,20-tetra(m-hydroxyphenyl)bacteriochlorin] related to the tetra(hydroxyphenyl)porphyrins have been prepared. They show the expected strong absorption bands in the red region of the visible spectrum and are found to be very effective tumour photosensitizers.
Bonnett
R
R
Department of Chemistry, Queen Mary College, London, U.K.
White
R D
RD
Winfield
U J
UJ
Berenbaum
M C
MC
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D051379:Mice; D011166:Porphyrins / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents
D000970:Antineoplastic Agents; D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; C051233:5,10,15,20-tetra(3-hydroxyphenyl)porphyrin; C051234:5,10,15,20-tetra(2-hydroxyphenyl)porphyrin; C051232:5,10,15,20-tetra(4-hydroxyphenyl)porphyrin