Applicability of continuous-flow fast atom bombardment liquid chromatography-mass spectrometry in bioanalysis. Dextromethorphan in plasma.
Continuous-flow fast atom bombardment (CF-FAB) is an interface for combined liquid chromatography-mass spectrometry using FAB as the ionization method. The applicability of CF-FAB for quantitative bioanalysis was studied for a model compound, dextromethorphan, in plasma samples using conventional high-performance liquid chromatography. The flow-rate reduction was achieved either by splitting or by the phase-system switching approach. The features of both systems are discussed.
TNO-CIVO Institute, Zeist, The Netherlands.
P
P
Kokkonen
W M
WM
Niessen
U R
UR
Tjaden
J
J
van der Greef
D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D003915:Dextromethorphan / Q000097:blood*; D006801:Humans; D007981:Levorphanol / Q000031:analogs & derivatives*; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*
D007981:Levorphanol; D003915:Dextromethorphan