Ether does not antagonize bronchoconstriction caused by acetylcholine, histamine, or phenylephrine.
The effect of ether as a possible antagonist of mediator-effected bronchoconstriction was tested in eight anesthetized, paralyzed, and mechanically ventilated baboons. Ether administered intravenously had no effect on bronchoconstriction caused by acetylcholine, histamine, or phenylephrine administered by the same route, either alone or in combination with propranolol.
Department of Clinical Pharmacology, Godfrey Huggins School of Medicine, Avondale, Harare, Zimbabwe.
P
P
Neill
J W
JW
Sleigh
D000109:Acetylcholine / Q000009:adverse effects*; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy*; D001980:Bronchi / Q000187:drug effects*; D003251:Constriction, Pathologic; D004986:Ether / Q000494:pharmacology / Q000627:therapeutic use*; D005019:Ethyl Ethers / Q000627:therapeutic use*; D006632:Histamine / Q000009:adverse effects*; D007262:Infusions, Intravenous; D008168:Lung / Q000502:physiology; D010656:Phenylephrine / Q000009:adverse effects*; D011312:Pressure; D012123:Pulmonary Ventilation / Q000187:drug effects
D005019:Ethyl Ethers; D004986:Ether; D010656:Phenylephrine; D006632:Histamine; D000109:Acetylcholine