[Mechanism of phasic fluctuations of glycemia after administration of diabetogenic substances].
Dithizone induces similar glycemic changes in rabbits, golden hamsters and mice (triphasic fluctuations resulting in diabetes). In rabbits who received 8-(p-toluenesulfonylamino)-quinoline, 8-(benzenesulfonylamino)-quinoline or alloxan, the glycemic reaction is similar to that observed after a dithizone injection. A degree of glycemic reaction to chromophiric chelants injected to animals, depends on their accumulation in the lysosome-segregation apparatus, of insulin producing cells (acidotropic action).
E D
ED
Gold'berg
V A
VA
Eshchenko
D000496:Alloxan / Q000633:toxicity; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced*; D004230:Dithizone / Q000633:toxicity; D008647:Mesocricetus; D051379:Mice; D011804:Quinolines / Q000633:toxicity; D011817:Rabbits; D013997:Time Factors
D001786:Blood Glucose; D011804:Quinolines; D004230:Dithizone; D000496:Alloxan
K mekhanizmu faznykh kolevaniĭ glikemii pri vvedenii diabetogennykh veshchestv.