[Theoretical and practical problems posed by the measurement of capillary filtration by radioactive tracers].
Screening for abnormal capillary filtration in the limbs with radioactive tracers requires the use of molecules of a known hydrodynamic radius. The molecule labeling should be obtained with a pure gamma-emitting radioactive atom, presenting a steady bond with the molecule, in vivo. Indium-111-labeled albumin appears to be the best tracer, and should be injected concurrently with the technetium 99m-labeled erythrocytes. The latter tracer permits assessing volume variations induced by the venous blood return block needed to obtain a capillary pressure increase. A qualitative estimation of lymphatic flow, and screening for abnormal permeability of the lymphatic vessels must be carried out as part of any capillary filtration study protocol.
Service de Biophysique et Médecine Nucléaire, Centre Hospitalier Régional, La Tronche.
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Comet
D002199:Capillary Permeability; D006801:Humans; D007205:Indium Radioisotopes; D007866:Leg / Q000098:blood supply*; D013667:Technetium
D007205:Indium Radioisotopes; D013667:Technetium
Problèmes théoriques et pratiques posés par la mesure de la filtration capillaire avec des traceurs radioactifs.