[Changes in the activity of plasma renin and aldosterone induced by a pattern of increasing administration of zinc sulphate in normotensive individuals].
The behavior of the renin-angiotensin-aldosterone system was evaluated in response to an increasing zinc intake. This oligoelement can modify the activity of the angiotensin I converting enzyme (ACE). Six healthy normotensive volunteers received 30 mg of zinc sulphate orally for 4 days and 600 mg for 4 additional days. On the first, fifth and ninth days plasma renin activity (PRA) and serum aldosterone were measured, and the possible changes in blood pressure were evaluated. PRA and aldosterone showed significant increases, with a stepwise distribution throughout the zinc overload. On the first day, PRA was 0.40 +/- 0.08 ng/ml/h; on the fifth day it was 0.80 +/- 0.21 ng/ml/h, and on the ninth day 1.39 +/- 0.34 ng/ml/h (1st-5th day; p less than 0.05; 1st-9th day: p less than 0.02). On the first day, the aldosterone levels were 81 +/- 17 pg/ml, on the fifth day they were 119 +/- 26 pg/ml, and on the ninth day 164 +/- 30 pg/ml (1st-5th day: nonsignificant difference; 1st-9th day: p less than 0.02). The values of arterial pressure did not change significantly after zinc overload. It is concluded that zinc overload can modify PRA and aldosterone levels, and that these changes are dose-related.
M
M
Calero
A
A
Sampalo
J E
JE
Millán
J
J
Freire
A
A
Senra
E
E
Zamora
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D006801:Humans; D008297:Male; D012084:Renin-Angiotensin System / Q000187:drug effects*; D013431:Sulfates / Q000008:administration & dosage / Q000494:pharmacology*; D015032:Zinc / Q000008:administration & dosage / Q000494:pharmacology*; D019287:Zinc Sulfate
D013431:Sulfates; D019287:Zinc Sulfate; D015032:Zinc
Modificaciones en la actividad de renina plasmática y aldosterona provocadas por una pauta de administración creciente de sulfato de cinc en individuous normotensos.