Infrared immunoassay.
An immunoassay method based on the labelling of an antigen with a transition-metal carbonyl organometallic marker and detection of the label by Fourier transform infrared (FT-IR) spectroscopy is described. The viability of this novel non-isotopic approach, termed infrared immunoassay (IRIA), has been evaluated in the quantitative determination of the tricyclic antidepressant nortriptyline.
Department of Chemistry, McGill University, Montreal, Quebec, Canada.
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AA
Ismail
G
G
Jaouen
P
P
Cheret
P
P
Brossier
D000818:Animals; D000906:Antibodies / Q000032:analysis; D005583:Fourier Analysis; D007118:Immunoassay / Q000379:methods; D009661:Nortriptyline / Q000032:analysis; D009942:Organometallic Compounds / Q000378:metabolism; D011817:Rabbits; D013055:Spectrophotometry, Infrared
D000906:Antibodies; D009942:Organometallic Compounds; D009661:Nortriptyline