Biodistribution and radiation absorbed dose of (N-methyl[11C])pyrilamine: a histamine H-1 receptor radiotracer.
The in vivo biodistribution for (N-methyl[11C])pyrilamine in mice is reported for various times after i.v. bolus injection, together with estimates of the radiation absorbed dose for the same radiotracer in man. More than 60% of the injected dose was excreted via the kidneys in urine after 90 min post injection. The brain regional distribution in mice showed a favorable hypothalamus-to-cerebellum ratio, indicative of H-1 receptor binding, encouraging in vivo histamine H-1 receptor imaging studies in man.
Yanai
K
K
Division of Nuclear Medicine and Radiation Health Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21205-2179.
Dannals
R F
RF
Wilson
A A
AA
Ravert
H T
HT
Scheffel
U
U
Tanada
S
S
Wagner
H N
HN
D000631:Aminopyridines; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging; D002250:Carbon Radioisotopes; D008297:Male; D051379:Mice; D011738:Pyrilamine / Q000493:pharmacokinetics; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D011970:Receptors, Histamine H2 / Q000032:analysis*; D014018:Tissue Distribution
D000631:Aminopyridines; D002250:Carbon Radioisotopes; D011970:Receptors, Histamine H2; D011738:Pyrilamine