Lumbar CSF eicosanoids in neonates.
Lumbar CSF eicosanoids were measured in 11 neonates with perinatal asphyxia and 12 neonates with suspected sepsis. In the asphyxia group low levels of thromboxane B2 and prostaglandin F2a were detected in five neonates, all of which had had a lumbar puncture prior to 4 hours of age. In the group with suspected sepsis two infants had positive blood cultures and one had strep meningitis. CSF eicosanoids were nondetectable in all patients in this second group with the exception of the infant with meningitis. With meningitis CSF eicosanoids were markedly elevated. These findings suggest that lumbar CSF eicosanoids do not appear to be a clinically useful tool. The data further suggest that eicosanoids are involved in the inflammatory response to meningitis.
Mirro
R
R
Department of Pediatrics, Obstetrics and Gynecology, University of Tennessee, Memphis 38163.
Armstead
W M
WM
Beasley
D G
DG
Leffler
C W
CW
D001238:Asphyxia Neonatorum / Q000134:cerebrospinal fluid; D015237:Dinoprost / Q000134:cerebrospinal fluid; D004537:Eicosanoic Acids / Q000134:cerebrospinal fluid*; D006801:Humans; D007231:Infant, Newborn / Q000134:cerebrospinal fluid*; D008161:Lumbosacral Region; D011863:Radioimmunoassay; D018805:Sepsis / Q000134:cerebrospinal fluid; D013929:Thromboxane B2 / Q000134:cerebrospinal fluid
D004537:Eicosanoic Acids; D013929:Thromboxane B2; D015237:Dinoprost