Norethandrolone produces temporary loss of the ability to escape from salt-retaining steroids.
Patients with diseases characterized by salt retention manifest a loss of the normal ability of healthy persons to escape from repeat injections of aldosterone or other salt-retaining steroids. This phenomenon may be a clue to the pathophysiological mechanisms of salt retention. Administration of norethandrolone to a subject who had demonstrated the ability to escape from the salt-retaining effect of corticosteroid administration temporarily and reversibly deleted his ability to escape. Thus norethandrolone administration provides the basis for a model system for exploring the mechanisms of escape (and therefore of salt retention).
Zumoff
B
B
Department of Medicine, Beth Israel Medical Center, New York, NY 10003.
D001835:Body Weight / Q000187:drug effects; D004958:Estradiol / Q000627:therapeutic use* / Q000652:urine; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use* / Q000652:urine; D008297:Male; D008875:Middle Aged; D009639:Norethandrolone / Q000009:adverse effects*; D012964:Sodium / Q000378:metabolism*; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects
D004958:Estradiol; D012964:Sodium; D009639:Norethandrolone; D006854:Hydrocortisone