Use of cisplatin for control of metastatic malignant mesenchymoma and hypertrophic osteopathy in a dog.
Cisplatin (cis-diammine-dichloroplatinum) treatment induced partial remission of pulmonary metastatic malignant mesenchymoma and nearly complete radiographic remission of hypertrophic osteopathy in a 14-year-old Beagle. Cisplatin was given once every 3 weeks. Clinical signs of hypertrophic osteopathy resolved one week after initiation of treatment. Partial remission of pulmonary metastases and partial radiographic remission of hypertrophic osteopathy was seen 6 weeks after initiation of treatment. Previous treatment of neoplasia-related hypertrophic osteopathy has consisted of removal of the initiating mass or vagotomy. In this case, appropriate chemotherapy was used to control clinical signs and progression of hypertrophic osteopathy.
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-7403.
K A
KA
Hahn
R C
RC
Richardson
D000818:Animals; D001847:Bone Diseases / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D002945:Cisplatin / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D006984:Hypertrophy; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000662:veterinary*; D008637:Mesenchymoma / Q000150:complications / Q000188:drug therapy / Q000556:secondary / Q000662:veterinary*; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy / Q000662:veterinary; D012983:Soft Tissue Neoplasms / Q000150:complications / Q000188:drug therapy / Q000662:veterinary
D002945:Cisplatin