Prevention of tourniquet pain by spinal isobaric bupivacaine with clonidine.
In order to assess the effect of spinal clonidine on tourniquet pain, 30 patients scheduled to undergo orthopaedic surgery under spinal anaesthesia were allocated randomly to two groups. Patients in group I (n = 15) received 0.5% isobaric bupivacaine 15 mg plus isotonic saline 1 ml. Patients in group II (n = 15) received 0.5% bupivacaine 15 mg plus clonidine 1 ml (150 micrograms). Sensory block was evaluated by pinprick and motor block with Bromage's scale. The presence of clonidine significantly prolonged the duration of sensory and motor block. Three patients in group I, but none in group II, experienced tourniquet pain. Hypotension and bradycardia were not worsened by spinal clonidine. The use of clonidine may be a useful technique to augment bupivacaine spinal block.
Département d'Anesthésie Réanimation No. II, Hôpital Henri Mondor, Creteil, France.
F
F
Bonnet
A
A
Diallo
M
M
Saada
M
M
Belon
M
M
Guilbaud
O
O
Boico
D000328:Adult; D000368:Aged; D000775:Anesthesia, Spinal; D002045:Bupivacaine / Q000008:administration & dosage; D003000:Clonidine / Q000008:administration & dosage; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000517:prevention & control*; D011446:Prospective Studies; D011897:Random Allocation; D012677:Sensation / Q000187:drug effects; D013046:Specific Gravity; D013997:Time Factors; D014111:Tourniquets / Q000009:adverse effects*
D003000:Clonidine; D002045:Bupivacaine