Doxorubicin-loaded nanoparticles: increased efficiency in murine hepatic metastases.
Free doxorubicin and doxorubicin associated with polyisohexlycyanoacrylate were tested for their therapeutic efficiency in hepatic metastasis-bearing mice. The metastases originated from the M 5076 reticulum cell sarcoma. Irrespective of the dose and the administration schedule, the reduction of the number of metastases was much larger with the doxorubicin-loaded nanoparticles than with free doxorubicin. This was clearly confirmed by histological examination. Although pharmacological and pharmacokinetic data indicated a strong capture of the nanoparticles by the hepatic issue, the mechanism of nanoparticle therapeutic efficiency remains unclear.
Laboratoire de Pharmacie Galenique et Biopharmacie, Faculte de Pharmacie, Universite de Paris-Sud, Chatenay-Malabry, France.
N
N
Chiannilkulchai
Z
Z
Driouich
J P
JP
Benoit
A L
AL
Parodi
P
P
Couvreur
D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008099:Liver / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000556:secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D008863:Microspheres; D009368:Neoplasm Transplantation; D011108:Polymers
D011108:Polymers; D004317:Doxorubicin