[Comparative clinico-immunologic and microcirculation studies in families of patients with type 1 diabetes mellitus and systemic lupus erythematosus].
Presented are findings of comparative studies of the clinico-immunological parameters and the microcirculatory bed status in 17 DM I probands and 37 of their family members and in 17 SLE probands with 54 of their relatives. The DM I families were found to have DM and prediabetic cases, while among the SLE probands' families rheumatic and, less frequently, cardiovascular diseases prevailed. In the DM I probands' families, a significantly greater number of relatives were found to have rheumatoid factor, high IgG level, anti-DNA antibodies, and CIC (as compared to the SLE series). Both DM I and SLE groups demonstrated reduced efficacy of the cutaneous circulation as compared to norm; in the DM I relatives this disorder was more pronounced than in SLE relatives. The degree to which circulatory changes were pronounced was related to immunological disorders.
Nasonova
V A
VA
Denisov
L N
LN
Mazovetskiĭ
A G
AG
Mach
E S
ES
Babadzhanova
T A
TA
D000328:Adult; D000368:Aged; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D012867:Skin / Q000098:blood supply*
Sravitel'nye kliniko-immunologicheskie i mikrotsirkuliatornye issledovaniia v sem'iakh bol'nykh sakharnym diabetom 1 tipa i sistemnoĭ krasnoĭ volchankoĭ.