Distribution of aluminium following intraperitoneal injection of aluminium lactate in the rat.
An animal experiment was performed to evaluate the absorption and distribution of aluminium in serum and tissues of normal rats. The animals were intraperitoneally injected with an aluminium lactate solution at a pH adjusted to 7.0. Before starting, a short preliminary study was carried out in order to verify the validity of the treatment with aluminium lactate instead of aluminium chloride at endogenous pH 3.4. Thirty-one rats were used in the main experiment, divided in four groups. In treated animals, the total Al-administered dose was 75.6 mg during 78 days of treatment. Furthermore, to evaluate the influence of the parathyroid hormone on Al absorption and/or distribution, 200 USP/rat of parathyroid hormone extract (PTH) were also administered during the last 5 days of the experiment. Aluminium content in serum, tibia, rib, brain, liver, muscle, kidney and spleen was determined. Calcium analysis in serum and bone was also performed. The highest concentrations of aluminium were found in liver and spleen, whereas the lowest level was found in the brain. The PTH effect on Al absorption was evident in brain and bone.
Istituto Superiore di Sanita, Applied Toxicology Laboratory, Rome, Italy.
S
S
Costantini
R
R
Giordano
A
A
Ioppolo
A
A
Mantovani
P
P
Ballanti
P
P
Mocetti
E
E
Bonucci
D000535:Aluminum / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000378:metabolism; D007773:Lactates / Q000008:administration & dosage* / Q000097:blood; D019344:Lactic Acid; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D013977:Tibia / Q000378:metabolism; D014018:Tissue Distribution
D007773:Lactates; D019344:Lactic Acid; D000535:Aluminum