Is immunotherapy for habitual aborters an immunologically hazardous procedure for infants?
Physical development and tests of immunologic function are reported from the first year of life for 13 infants born to mothers who were habitual aborters and who had undergone subcutaneous vaccination with their husband's lymphocytes. The mean weight of the infants at birth was 2,975 +/- 540 g, including one infant who was small for dates. Physical development parameters for the first year were all within normal range. Immunologic studies were performed at ages 0, 1, 3, 6, 9, and 12 months. The studies included the following: (1) serum levels of immunoglobulins and complement components; (2) the number of peripheral blood lymphocytes (PBL) and their subpopulations; and (3) proliferative responses by PBL against unrelated lymphocytes and some mitogens (pokeweed, phytohemagglutinin, and concanavalin A). All were normal when compared with studies of infants of nonimmunized mothers. These observations suggested that subcutaneous vaccination of women with their husband's lymphocytes did not result in any adverse effects on their infants' physical or immunologic development.
Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan.
K
K
Takakuwa
S
S
Goto
I
I
Hasegawa
H
H
Ueda
T
T
Maruhashi
T
T
Kajino
H
H
Yoshizawa
K
K
Kanazawa
S
S
Takeuchi
D000026:Abortion, Habitual / Q000628:therapy*; D002657:Child Development; D003165:Complement System Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D007107:Immune System / Q000254:growth & development; D007121:Immunocompetence; D007136:Immunoglobulins / Q000378:metabolism; D007167:Immunotherapy / Q000009:adverse effects*; D007223:Infant; D007231:Infant, Newborn; D008213:Lymphocyte Activation; D008297:Male; D011247:Pregnancy
D007136:Immunoglobulins; D003165:Complement System Proteins