Sucralfate delays gastric emptying of liquids and solids in duodenal ulcer patients.
Gastric emptying studies were performed on nine healthy volunteers and ten duodenal ulcer (DU) patients utilizing a dual radionuclide technique to assess simultaneously emptying rates of liquid (111In labeled water) and solid (99mTc sulfur colloid labeled chicken liver) components of a meal. One gram of sucralfate was compared to placebo in separate days in a randomized double-blind crossover fashion. Subjects ingested the radiolabeled test meal 1 h after receiving medication, and gastric emptying was monitored for 3 h using a gamma camera interfaced with a computer. We found that DU patients had significantly faster gastric emptying of solids (P less than 0.05) compared to normals on the placebo days, while liquid emptying rates were similar. Sucralfate, in the DU patients, significantly (P less than 0.05) slowed gastric emptying of water from 20 to 40 min and emptying of the solid component from 100-160 min after the meal compared to placebo. In normal subjects, gastric emptying of liquids and solids was not significantly affected by sucralfate. We conclude that slowing of gastric emptying, possibly mediated through aluminum ions, occurs in DU patients on sucralfate. This may be one mechanism by which sucralfate enhances healing and decreases recurrence of duodenal ulcer.
Department of Medicine, Yale University School of Medicine, Hospital of Saint Raphael, New Haven, CT 06511.
J M
JM
Petersen
V J
VJ
Caride
E K
EK
Prokop
F J
FJ
Troncale
R W
RW
McCallum
D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D005502:Food; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D011897:Random Allocation; D013392:Sucralfate / Q000627:therapeutic use*; D013671:Technetium Tc 99m Sulfur Colloid
D007205:Indium Radioisotopes; D013392:Sucralfate; D013671:Technetium Tc 99m Sulfur Colloid