2-cyclohexene-1-one-induced hyperglycemia in the mice.
2-Cyclohexene-1-one (CHX) dose-dependently caused the elevation of blood glucose levels in both fed and fasted mice. Adrenalectomy considerably prevented the elevated blood glucose with CHX, and plasma adrenaline assays revealed about a three- to fifteen-fold rise after CHX treatment. These findings indicate that the CHX-induced hyperglycemia may be largely mediated by adrenaline released from the adrenal medulla.
Department of Biology and Clinical Physiology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
T
T
Masukawa
M
M
Sai
Y
Y
Tochino
D000315:Adrenalectomy; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003345:Corticosterone / Q000494:pharmacology; D003510:Cyclohexanes / Q000494:pharmacology*; D003512:Cyclohexanones / Q000494:pharmacology*; D004837:Epinephrine / Q000097:blood / Q000494:pharmacology; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR
D001786:Blood Glucose; D003510:Cyclohexanes; D003512:Cyclohexanones; C028215:2-cyclohexen-1-one; D003345:Corticosterone; D004837:Epinephrine