[Depression of penicillin-evoked seizure discharges of cerebrospinal neurons by magnesium ions].
In experiments on narcotized spinal cats perfusion of the lumbosacral segments of the spinal cord with penicillin (50 mmol/l) containing artificial cerebrospinal fluid led to the appearance of spontaneous negative small potentials in the dorsal roots and spontaneous repetitive bursts of impulses in the ventral roots of the perfused segments. The epileptogenic activity of penicillin was reduced or completely blocked if administration of the penicillin containing cerebrospinal fluid was preceded by 20-30 minute perfusion of the central canal of the lumbosacral segments with cerebrospinal fluid containing a high concentration of magnesium ions.
Kornilov
O V
OV
Ruchinskaia
T Iu
TIu
Sverdlov
Iu S
IuS
D000818:Animals; D002415:Cats; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D005071:Evoked Potentials / Q000187:drug effects; D008274:Magnesium / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010406:Penicillins / Q000037:antagonists & inhibitors* / Q000633:toxicity; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology
D010406:Penicillins; D008274:Magnesium
Ugnetenie ionami magniia vyzvannykh penitsillinom sudorozhnykh razriadov spinnomozgovykh neĭronov.