Effect of food on the absorption of vigabatrin.
1. This study, involving eight healthy volunteers, revealed that food intake does not have a clinically significant effect on vigabatrin kinetics. 2. Kinetics of vigabatrin in the fasting state showed low inter-individual variation. 3. The plasma concentration vs time profile followed a bi-exponential decline with a terminal half-life of 6.8 h and a relative bioavailability of 92% +/- 11%. 4. In the clinical setting, vigabatrin may be taken at times convenient for the patient.
Service de Pharmacologie Clinique, I.N.S.E.R.M. U7, Paris, France.
M
M
Frisk-Holmberg
P
P
Kerth
P
P
Meyer
D000293:Adolescent; D000328:Adult; D000614:Aminocaproates / Q000009:adverse effects / Q000493:pharmacokinetics*; D000927:Anticonvulsants / Q000009:adverse effects / Q000493:pharmacokinetics*; D001682:Biological Availability; D005502:Food; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D011897:Random Allocation; D020888:Vigabatrin
D000614:Aminocaproates; D000927:Anticonvulsants; D020888:Vigabatrin