[Lipid peroxidation as a mechanism of bioenergetic regulation in inflammation of the respiratory organs].
Oxidative phosphorylation, the content of lipids, diene++ conjugates, and malonic dialdehyde, catalase activity in hepatic mitochondria, and antioxidative activity of the postmitochondrial fraction of the liver were studied during the development of inflammation of the lungs in rats (in periods of 3 days to 3 months). The metabolic condition of the mitochondria changes in these periods of the disease from limited hyperactive to inhibited hyperactive with diminution of oxidation and phosphorylation conjugation. This is attended by an increase of the relative content of lipids (increase of diene++ conjugate and decrease of malonic dialdehyde level). Changes of catalase activity correlate with the dynamics of changes of the phosphorylation coefficient. It is assumed that the regulation of bioenergetic processes is realized by modification of the mitochondrial membrane structures, increased utilization of lipids as a respiratory substrate, as well as by changes in the activity of the factors of lipid peroxidation control which may be regulators of oxidation and phosphorylation conjugation.
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Semenov
D000818:Animals; D004734:Energy Metabolism; D015227:Lipid Peroxidation; D011014:Pneumonia / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
Perekisnoe okislenie lipidov kak mekhanizm bioénergeticheskoĭ reguliatsii pri vospalenii organov dykhaniia.