Isolation of flavonoids and a chalcone from Helichrysum odoratissimum and synthesis of helichrysetin.
3,5-Dihydroxy-6,7,8-trimethoxyflavone, 3-O-methylquercetin, and helichrysetin were isolated from the flowers of the Rwandese medicinal plant, Helichrysum odoratissimum. Because of inconsistencies of the mp of the latter chalcone, a synthesis of helichrysetin was developed. 3-O-Methylquercetin was shown to be an active principle as it displayed antimicrobial activity.
Centre Universitaire de Recherche sur la Pharmacopée et la Médecine Traditionnelle, Université Nationale du Rwanda, Butare.
L
L
Van Puyvelde
N
N
De Kimpe
J
J
Costa
V
V
Munyjabo
S
S
Nyirankuliza
E
E
Hakizamungu
N
N
Schamp
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology; D002599:Chalcone / Q000031:analogs & derivatives / Q000096:biosynthesis* / Q000138:chemical synthesis / Q000302:isolation & purification*; D005419:Flavonoids / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000032:analysis*; D011427:Propiophenones / Q000096:biosynthesis* / Q000302:isolation & purification*
D000890:Anti-Infective Agents; D005419:Flavonoids; D011427:Propiophenones; D002599:Chalcone; C061023:helichrysetin