Roxithromycin in the treatment of pneumonia.
An open multicentre study of the efficacy and side effects of roxithromycin, a new macrolide antibiotic, in the treatment of community acquired pneumonia was undertaken. The diagnosis was verified by transtracheal aspiration. Fifty-three patients were studied. In the 49 patients evaluable the clinical efficacy rate was 92% (95% confidence limits 84-100%). Only by measurement of the fall in serum C-reactive protein was it possible to detect a difference in response between pneumonia due to Streptococcus pneumoniae and Haemophilus influenzae. The drug was well tolerated clinically and laboratory abnormalities included transient eosinophilia and elevated liver enzymes in two patients.
Department of Infectious Diseases, Marselisborg Hospital, Aarhus C, Denmark.
N A
NA
Peterslund
P
P
Hänninen
A
A
Schreiner
F T
FT
Black
V
V
Hultén
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D003718:Denmark; D005260:Female; D005387:Finland; D006192:Haemophilus Infections / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007933:Leucomycins / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009664:Norway; D011014:Pneumonia / Q000188:drug therapy* / Q000382:microbiology; D013997:Time Factors
D007933:Leucomycins; D002097:C-Reactive Protein