A non-parametric grading system for intestinal metaplasia: correlations with gastric tissue enzymes.
A novel method for grading intestinal metaplasia, with general applicability, is described. Highly significant agreement was found by kappa analysis both for intra-observer (k = 0.90) and for inter-observer (k = 0.85) variation, confirming the reproducibility of the method. The ranks derived by this method were correlated with gastric tissue levels of the enzymes beta-glucuronidase, lactic dehydrogenase (LDH), and %m-LDH. A significant (P less than 0.05) positive correlation was found between intestinal metaplasia and %m-LDH, but there was no correlation between intestinal metaplasia and beta-glucuronidase or LDH.
St. George's Hospital Medical School, London, U.K.
P J
PJ
Finch
M E
ME
Fallowfield
D005753:Gastric Mucosa / Q000201:enzymology*; D005966:Glucuronidase / Q000032:analysis; D006801:Humans; D007422:Intestines / Q000473:pathology*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008679:Metaplasia / Q000201:enzymology / Q000473:pathology
D007770:L-Lactate Dehydrogenase; D005966:Glucuronidase