Depletion of hypothalamic norepinephrine reduces the fever induced by polyriboinosinic acid: polyribocytidylic acid (Poly I:Poly C) in rats.
Administration of either Poly I:Poly C (0.05-0.50 micrograms) or norepinephrine (2-8 micrograms) into the anterior hypothalamic area produced a dose-related fever in rats. The fever induced by Poly I:Poly C was attenuated after selective depletion of norepinephrine in the hypothalamus. However, selective depletion of hypothalamic norepinephrine did not affect the fever induced by intrahypothalamic norepinephrine. The data indicate that Poly I:Poly C may act to induce fever through the endogenous release of norepinephrine from the rat's hypothalamus.
Department of Physiology, Taipei Medical College, Taiwan, ROC.
H J
HJ
Liu
C M
CM
Young
M T
MT
Lin
D000818:Animals; D004298:Dopamine / Q000378:metabolism; D005334:Fever / Q000139:chemically induced / Q000378:metabolism / Q000628:therapy*; D006892:Hydroxydopamines / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D011070:Poly I-C / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D006892:Hydroxydopamines; D011070:Poly I-C; D004298:Dopamine; D009638:Norepinephrine