Very high dose intravenous gammaglobulin in thrombocytopenia of pregnancy.
A 22-year-old woman with severe idiopathic thrombocytopenic purpura, complicating pregnancy, was unresponsive to high-dose corticosteroids and three separate infusions of high-dose intravenous immunoglobulin using the conventional schedule of 400 mg/kg/d for five days. A dramatic albeit transient, elevation of her platelet count followed a six day course of very high dose immunoglobulin (1000 mg/kg/d) thus allowing elective lower segment cesarean section to be performed without complications and with the delivery of a live, female infant. Two months later a further course of very high dose gammaglobulin was again effective in raising the patient's platelet count prior to elective splenectomy. No adverse reactions were seen to either infusion.
Gibson
J
J
Hematology Department, Royal Prince Alfred Hospital, NSW.
Laird
P P
PP
Joshua
D E
DE
Child
A
A
Harris
J
J
Kronenberg
H
H
D000328:Adult; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000627:therapeutic use*; D007231:Infant, Newborn; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy*; D011696:Purpura, Thrombocytopenic / Q000628:therapy*
D007074:Immunoglobulin G