Facilitation of retention performance in mice by pretest microinjection of AVP into dorsal or ventral hippocampus: differential influence of the peptide on appetitive task.
Pre-test local microinjection of arginine-vasopressin (AVP) into dorsal or ventral hippocampus resulted in an improvement of retention performance in an appetitively motivated task. Nevertheless, a better improvement appeared when AVP treatment was performed into ventral hippocampus suggesting a higher sensitivity of this part of hippocampus to the action of AVP. To examine a non-specific behavioral action of the peptide, the effect of AVP treatment on locomotor activity was assessed. When the treatment was given into ventral hippocampus, a reduction of locomotor activity was recorded, whereas after AVP injection into dorsal hippocampus, the peptide failed to alter locomotor activity.
Metzger
D
D
Laboratoire de Neurobiologie des Comportements, CNRS U.R.A. 372, Université de Provence, Marseille, France.
Alescio-Lautier
B
B
Soumireu-Mourat
B
B
D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects; D001127:Arginine Vasopressin / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects
D001127:Arginine Vasopressin