Trisomy 12 and translocation (7;9) in an ovarian immature teratoma.
We report a case of an immature malignant ovarian teratoma with peritoneal implants diagnosed in an 18-year-old woman. The tumor was brought into remission after surgery (three laparotomies) and adjuvant chemotherapy. A residual peritoneal implant showed a mature epithelial and glial configuration. Histologically, the neuroectodermal component was dominant in the original tumor as well as in the metastases, being confirmed by immunohistochemistry and electron microscopy. A stem cell line has been obtained with cell culture, having a germ cell character and a yolk sac configuration. This line possessed a trisomy 12 and a translocation (7;9) similar to other chromosomal abnormalities described in immature teratomas of the testes and ovaries.
Department of Pathology, University of Valencia Medical School, Spain.
C
C
López Ginés
R
R
Gil
A
A
Pellin
M
M
Martorell
F
F
Vilar
A
A
Llombart-Bosch
D000293:Adolescent; D002881:Chromosomes, Human, Pair 12; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D007621:Karyotyping; D008854:Microscopy, Electron; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D013724:Teratoma / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic; D014314:Trisomy