Plasma alpha 1B-glycoprotein allele frequencies in Finns and Swedish Lapps: evidence for a new alpha 1B allele.
A new allele (A1B*5) of human plasma alpha 1B-glycoprotein (alpha 1B) was reported. alpha 1B phenotyping was done by two-dimensional agarose gel (pH 5.4)-horizontal polyacrylamide gel (pH 9.0) electrophoresis followed by protein staining. The alpha 1B phenotypes 1-1, 1-2, 1-5 and 2-2 were observed in Finns and phenotypes 1-1, 1-2, 1-5 and 2-5 in Swedish Lapps. The respective frequencies of A1B*1, A1B*2 and A1B*5 were 0.9575, 0.0350, 0.0075 in Finns and 0.8922, 0.0653, 0.0425 in Swedish Lapps. The Swedish Lapps showed a higher degree of alpha 1B polymorphism (polymorphism information content = 0.19) than other Caucasian populations that have been studied.
Juneja
R K
RK
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala.
Beckman
G
G
Lukka
M
M
Gahne
B
B
Ehnholm
C
C
D000483:Alleles; D001798:Blood Proteins / Q000032:analysis / Q000235:genetics*; D015180:Electrophoresis, Gel, Two-Dimensional; D005387:Finland; D005787:Gene Frequency; D006023:Glycoproteins; D006801:Humans; D007136:Immunoglobulins; D010641:Phenotype; D013548:Sweden
C048566:A1BG protein, human; D001798:Blood Proteins; D006023:Glycoproteins; D007136:Immunoglobulins