Daily variation in maternal and fetal weight gain in mice and hamsters.
Daily variation in maternal and fetal weight gain was measured in hamsters (Mesocricetus auratus) and in mice (Mus musculus, C57Bl) with free access to food or under restricted feeding schedules. Pregnant hamsters with free access to food and water were weighed twice a day and fetuses were collected twice a day from 10.5 to 14.5 days after fertilization. In three experiments, pregnant mice were given free access to food and water or were allowed food for 12 hours a day or for 6 hours a day. Pregnant mice were weighed twice a day and in the restricted feeding experiments, fetuses were collected every 6 hours from 12.0 to 14.5 days after fertilization. Pregnant mice and hamsters with free access to food showed a daily rhythm in weight gain with greater gain at night. There was no evidence of a daily rhythm in the weight gain with greater gain at night. There was no evidence of a daily rhythm in the weight gain of hamster fetuses. Mouse fetuses showed greater weight gain during two 6-hour intervals each day, the second half of each night and the second half of each day. The 12-hour variation was seen in both wet and dry fetal weight. A 24-hour rhythm in fetal growth was previously described in rats (Barr: Teratology, 7:283-288, 1973). Results in rats and mice indicate that fetal growth is modulated on a daily basis. The different periodicity observed in rats and mice might be related to the different ages of the fetuses examined.
Davis
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FC
Department of Biology, Northeastern University, Boston, Massachusetts 02115.
D000818:Animals; D002940:Circadian Rhythm; D006224:Cricetinae; D004435:Eating; D005314:Embryonic and Fetal Development; D005260:Female; D008647:Mesocricetus; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D015430:Weight Gain