Metabolic disturbances induced by organotins through subchronic treatment in chickens. First communication: growth dynamics, carbohydrate and protein metabolism.
Four organotin derivatives (tributyltin acid, dibutyltin chloride, triphenyltinchloride, and triphenyltin-bis (diethyl) dithiophosphate) were tested through subchronic treatment on 19 days old chickens. Growth dynamics as well as carbohydrate and protein metabolism were investigated, in order to evaluate their effects on metabolic activity. Biochemical liver and blood constituents revealed growth retardation and general depression of metabolic activity in experimental groups. Some correlations were found to exist chemical structure, dose use for compound, and effects. Butyltins were more toxic than phenylderivatives and their effects were proportionale to the dose.
Guta-Socaciu
C
C
Ghergariu
S
S
Giurgea
R
R
Coprean
D
D
D000818:Animals; D050260:Carbohydrate Metabolism; D002645:Chickens / Q000254:growth & development / Q000378:metabolism*; D009947:Organotin Compounds / Q000633:toxicity*; D011506:Proteins / Q000378:metabolism*
D009947:Organotin Compounds; D011506:Proteins