Methylprednisolone pulse therapy in severe dysthyroid optic neuropathy.
Five patients with severe dysthyroid optic neuropathy were treated with intravenous methylprednisolone (1 g daily for 3 consecutive days). Before administration, visual acuity of the more severely affected eyes of each patient was counting fingers at 5 feet, 8/200, 20/400, 20/200, and 20/80. Immediately after completion of pulse therapy, visual acuity improved to 20/25 in four patients and 20/30 in one. Remissions were maintained with oral prednisone and external beam irradiation of the orbit. Pulse methylprednisolone therapy appears to be beneficial in the initial management of severe dysthyroid optic neuropathy.
Department of Ophthalmology, University of Florida, College of Medicine, Gainesville 32610-0284.
J R
JR
Guy
S
S
Fagien
J P
JP
Donovan
M L
ML
Rubin
D000328:Adult; D005260:Female; D006111:Graves Disease / Q000188:drug therapy*; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage; D006973:Hypertension / Q000188:drug therapy; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D009915:Orbit / Q000528:radiation effects; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity; D014794:Visual Fields
D006852:Hydrochlorothiazide; D008775:Methylprednisolone