Pharmacokinetics of intravenous buprenorphine in children.
Buprenorphine (3 micrograms kg-1) was given intravenously as premedication to small children (age 4-7 years) undergoing minor surgery. Because of the rapid decline of the plasma buprenorphine concentrations, the terminal elimination half-life could not be estimated reliably. Given this constraint, values of clearance appeared to be higher than those in adults but values of Vss were similar.
Olkkola
K T
KT
Department of Clinical Pharmacology, University of Helsinki, Finland.
Maunuksela
E L
EL
Korpela
R
R
D002047:Buprenorphine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D011863:Radioimmunoassay
D002047:Buprenorphine