[Penetration and action of edoxudine in vitro and in vivo].
The penetration of 5-ethyl-2'-deoxyuridine (edoxudine, Aedurid) from gel base with and without the addition of urea and other adjuvant has been studied in an in vitro model using guinea pig skin. The formulation of 3% edoxudine gel with 5% urea showed the best results. In vivo experiments on hairless mice infected intracutaneously with herpes simplex virus type 1 also showed this formulation's good efficacy as compared to other formulations.
Kaul
R
R
Biochemische und Analytische Abteilung der Robugen GmbHa, Esslingen/Neckar, Leuven, Belgien.
Hempel
B
B
De Clercq
E
E
D000818:Animals; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D005079:Excipients; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000188:drug therapy; D066298:In Vitro Techniques; D051379:Mice; D008812:Mice, Hairless; D012869:Skin Absorption
D005079:Excipients; C022811:edoxudin; D003857:Deoxyuridine
Penetration und Wirksamkeit von Edoxudin in vitro und in vivo.