Hospitalizations for pulmonary reactions following nitrofurantoin use.
Acute pulmonary illness compatible with previously described nitrofurantoin toxicity and requiring hospitalization occurred three times among 16,101 first courses of therapy with nitrofurantoin. One case of fatal pulmonary fibrosis was ascribed to long-term use of nitrofurantoin among 742 observed recipients of ten or more prescriptions.
Jick
S S
SS
Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Waltham, MA 02154.
Jick
H
H
Walker
A M
AM
Hunter
J R
JR
D000208:Acute Disease; D000368:Aged; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009582:Nitrofurantoin / Q000009:adverse effects* / Q000627:therapeutic use; D011658:Pulmonary Fibrosis / Q000139:chemically induced*
D009582:Nitrofurantoin