B-vitamins potentiate the antinociceptive effect of diclofenac in carrageenin-induced hyperalgesia in the rat tail pressure test.
B-vitamins possess antinociceptive and antiinflammatory activity. The rat tail pressure test was used to examine whether a mixture of the vitamins B1, B6, and B12, clinically used as Neurobion, has antinociceptive activity itself or potentiates the effect of the non-steroidal antiinflammatory drug (NSAID) diclofenac on carrageenin-induced hyperalgesia. Only the highest dose of the vitamin mixture (667 mg/kg B1 and B6, 6.7 mg/kg B12 p.o.) exhibited antinociceptive activity. Nevertheless, lower doses which alone were lacking in activity (100-250 mg/kg B1 and B6, 1-2.5 mg/kg B12 p.o.) dose-dependently potentiated the antinociceptive of diclofenac. This result supports the clinical experience of a reduced need for diclofenac when B-vitamins are administered concomitantly.
E. Merck, Department of Pharmacology, Darmstadt, F.R.G.
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Bartoszyk
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D000284:Administration, Oral; D000700:Analgesics; D000818:Animals; D002351:Carrageenan; D004008:Diclofenac / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006930:Hyperalgesia / Q000139:chemically induced* / Q000188:drug therapy; D006941:Hyperesthesia / Q000139:chemically induced*; D008297:Male; D010147:Pain Measurement; D051381:Rats; D011919:Rats, Inbred Strains; D014803:Vitamin B Complex / Q000008:administration & dosage*
D000700:Analgesics; D014803:Vitamin B Complex; D004008:Diclofenac; D002351:Carrageenan