Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats.
The temporal requirements for theophylline-induced upregulation of A1 adenosine receptors and elevation of seizure threshold were examined. Chronic theophylline exposure (75 mg/kg twice daily) elicited a significant upregulation of [3H]cyclohexyladenosine ([3H]CHA) binding sites following 7 and 14 days of treatment. Alterations in seizure threshold followed a similar temporal pattern of development. The reversibility of theophylline-induced upregulation of high affinity [3H]CHA binding sites was complete at 10 days following cessation of theophylline administration, while the alteration of seizure threshold required 21 days to return to control values.
Sanders
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RC
College of Pharmacy, Oregon State University, Corvallis 97331.
Murray
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TF
D000241:Adenosine / Q000031:analogs & derivatives / Q000378:metabolism; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011983:Receptors, Purinergic / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D012640:Seizures / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D013806:Theophylline / Q000494:pharmacology*; D013997:Time Factors
D011983:Receptors, Purinergic; C027513:N(6)-cyclohexyladenosine; D013806:Theophylline; D000241:Adenosine; D001640:Bicuculline