Effect of manganese on some bioantioxidants in various organs of protein-deficient rats.
The effect of manganese exposure (Mn2+ 4 mg Mn/kg intraperitoneally) on certain bioantioxidants in brain, liver, kidney and testes in growing rats maintained on 21% and 8% casein diet were investigated. Manganese administration for 30 days caused significant reduction in the level of GSH (reduced glutathione) in liver and testes and GR (glutathione reductase) and G-6-PDH (glucose-6-phosphate dehydrogenase) in brain, liver and testes. The magnitude of alteration was greater in 8% casein diet fed animals compared to rats maintained on 21% casein diet. These results indicate that protein deficient animals are more susceptible to the manganese induced biochemical changes in various tissues. The mechanism of such changes is discussed.
Srivastava
R S
RS
Neurotoxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
Murthy
R C
RC
Chandra
S V
SV
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D020149:Manganese Poisoning; D010084:Oxidation-Reduction; D011488:Protein Deficiency / Q000378:metabolism*; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000378:metabolism
D005954:Glucosephosphate Dehydrogenase; D005980:Glutathione Reductase; D005978:Glutathione