The adrenergic properties of ring-brominated isoprenaline analogues.
The beta 1- and beta 2-adrenoceptor activity of the 2- and 6-ring-brominated analogues of isoprenaline were evaluated in vitro. The 2-bromo-substituted analogue exhibits a far greater activity on beta 1- and beta 2-receptors than the 6-bromo-substituted analogue.
Department of Pharmaceutical Chemistry, Potchefstroom University for Christian Higher Education, South Africa.
J H
JH
Langenhoven
D P
DP
Venter
T G
TG
Dekker
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects
D007545:Isoproterenol