An investigation of NCRC11 immunoreactivity in normal and neoplastic epithelia of the female genital tract and ovary.
NCRC11 is a monoclonal antibody raised against human mammary carcinoma cells. The prognostic value of tumour cell immunoreactivity to NCRC11 in breast cancer has been shown previously. This study describes NCRC11 immunoreactivity in a wide range of normal and neoplastic epithelial types from the female genital tract and ovary. In the tumours examined, a wide range of staining patterns was seen. The implications of these findings are discussed in relation to the potential uses of this antibody in diagnosis and monitoring of gynaecological diseases.
Department of Histopathology, City Hospital, Nottingham, UK.
A
A
Hitchcock
I O
IO
Ellis
J
J
Bell
A
A
Robins
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology; D001948:Brenner Tumor / Q000276:immunology / Q000473:pathology; D004717:Endometrium / Q000166:cytology / Q000276:immunology / Q000473:pathology; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology / Q000473:pathology; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D005836:Genitalia, Female / Q000166:cytology / Q000276:immunology*; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D010053:Ovary / Q000166:cytology / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm