Increased susceptibility to lipid peroxidation in skeletal muscles of dystrophic hamsters.
The results showed that the total content of lipids, which could be peroxidized with Fe(2 +)/ascorbate stimulation in vitro, was 45.4% and 53.7% higher than normal in the dystrophic hamster muscle at the age of 1 and 3 months, respectively. Correspondingly, the susceptibility to lipid peroxidation (stimulated by ADP-chelated iron at 37 degrees C) was 38.6-74.3% higher in dystrophic muscles. The increases were not related to necrotic lesions and inflammation observed. The activities of glucose-6-phosphate dehydrogenase, glutathione reductase, thioredoxin reductase and catalase were increased in dystrophic muscles but those of superoxide dismutases and glutathione peroxidase were unaffected.
Department of Cell Biology, University of Jyväskylä, Finland.
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A
Salminen
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Kihlström
D000818:Animals; D000975:Antioxidants; D003402:Creatine Kinase / Q000378:metabolism; D006224:Cricetinae; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D015227:Lipid Peroxidation; D009132:Muscles / Q000201:enzymology / Q000378:metabolism*; D009137:Muscular Dystrophy, Animal / Q000201:enzymology / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D013880:Thioredoxin-Disulfide Reductase / Q000378:metabolism
D000975:Antioxidants; D005954:Glucosephosphate Dehydrogenase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D013880:Thioredoxin-Disulfide Reductase; D003402:Creatine Kinase