Thiopental requirements for induction of anesthesia in neonates and in infants one to six months of age.
The authors determined the thiopental dose needed for satisfactory induction in ten neonates, 0-14 days of age, and 20 infants, 1-6 months of age. A single iv bolus of thiopental was given. Thirty seconds after injection the anesthesia mask was applied and the response was observed during the following 30 s while the patient breathed oxygen. Induction was considered satisfactory if there were no gross movements or coughing. The dose required for satisfactory induction in 50% of patients, ED50 (+/- SE), was 3.4 +/- 0.2 mg/kg in neonates and 6.3 +/- 0.7 mg/kg in infants (P less than 0.001). It is concluded that the thiopental dose needed for satisfactory induction is less in neonates than in infants.
Department of Anesthesia, University Hospital, Lund, Sweden.
P
P
Westrin
C
C
Jonmarker
O
O
Werner
D000771:Anesthesia, Intravenous / Q000379:methods; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D013874:Thiopental / Q000008:administration & dosage
D013874:Thiopental; D010100:Oxygen