Adenocarcinoma of the jejunum in association with celiac sprue.
An increased incidence of small bowel lymphoma in patients with long-standing celiac sprue is well documented in the literature. Less common is the association of adenocarcinoma of the small intestine. We report a patient with celiac sprue who initially responded to a gluten-free diet. Eighteen months later, diarrhea, abdominal cramps, and bloating was found to have its origin in partial small bowel obstruction. At laparotomy, two distinct adenocarcinomas of the jejunum were resected. Celiac patients who initially respond to gluten withdrawal and subsequently suffer exacerbation while adhering to strict dietary therapy should be carefully evaluated for evidence of a small bowel malignancy.
Department of Internal Medicine, University of South Florida College of Medicine, Tampa 33612-4799.
R J
RJ
Straker
S
S
Gunasekaran
P G
PG
Brady
D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology; D002446:Celiac Disease / Q000150:complications*; D005260:Female; D006801:Humans; D007580:Jejunal Neoplasms / Q000150:complications* / Q000473:pathology; D007583:Jejunum / Q000473:pathology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary