[The relationship between coronary artery stenosis and myocardial metabolism of oxygen demand in dogs].
In open chest dogs, a micrometer constrictor was used to produce three different coronary artery stenosis (AS) on left circumflex coronary artery, and hemodynamics, blood gas and coronary sinus pH, lactate were then measured. In mild coronary AS, resting coronary artery flow (CBF) did not decrease; but lactate increased. In critical coronary AS, CBF slightly decreased, MVO2 decreased and lactate increased. There was a decrease in CBF, O2 supply/consumption ratio, coronary sinus pH and an increase in oxygen extraction and lactate with severe coronary AS. The percent area stenosis (%AS) was highly correlated with O2 supply (r = -0.92), poorly correlated with MVO2 (r = -0.58) when it was higher than 75%.
Chen
S L
SL
Zang
Y M
YM
Zhu
M Z
MZ
Luo
B G
BG
Liu
D M
DM
Liang
H
H
D000818:Animals; D003326:Coronary Circulation; D003327:Coronary Disease / Q000378:metabolism*; D004285:Dogs; D005260:Female; D006439:Hemodynamics; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption