Survival of motoneurons following axotomy is enhanced by lactation or by progesterone treatment.
It was shown previously that neuron loss induced by nerve transection in the hypoglossal and facial motor nuclei of female rats could be reduced by long-term testosterone treatment following axotomy. In the present study, it is reported that such neuron loss could also be attenuated by lactation-related hormones and by progesterone treatment following axotomy.
Department of Cell Biology and Anatomical Sciences, City University of New York Medical School, NY 10031.
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D000818:Animals; D002452:Cell Count; D004305:Dose-Response Relationship, Drug; D005154:Facial Nerve / Q000187:drug effects / Q000502:physiology*; D005260:Female; D007002:Hypoglossal Nerve / Q000187:drug effects / Q000502:physiology*; D007774:Lactation; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology*; D009416:Nerve Regeneration / Q000187:drug effects*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011374:Progesterone