Autologous adrenal medullary transplant in progressive supranuclear palsy.
We transplanted autologous adrenal medullary cells to the caudate nucleus in 3 patients with progressive supranuclear palsy, using the method Madrazo has employed for neural transplantation in Parkinson's disease. Major and minor complications occurred post-operatively from which the patients recovered. One patient had a marked improvement in his postural stability and a decreased incidence of falling. This change was evident at 1 month after surgery and has remained for the 6 months of follow-up. Postural reflexes were not altered in the other 2 patients. There was no change in extraocular movements, speech, or the rigid-bradykinetic features of parkinsonism in any patient. Adrenal medullary transplantation has only limited efficacy in progressive supranuclear palsy.
Department of Neurology, University of Kansas Medical Center, Kansas City 66103.
W C
WC
Koller
R
R
Morantz
B
B
Vetere-Overfield
M
M
Waxman
D000313:Adrenal Medulla / Q000637:transplantation*; D000368:Aged; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011187:Posture; D012018:Reflex; D013494:Supranuclear Palsy, Progressive / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors