Acute coronary artery thrombosis in paroxysmal nocturnal hemoglobinuria.
We have reported a case of coronary artery thrombosis in a 36-year-old man with paroxysmal nocturnal hemoglobinuria (PNH), a potentially lethal thrombotic complication not previously documented in this unique patient population. Although the etiology of PNH remains unknown, the pathogenesis appears to be related to the deficiency of a specific membrane complement-regulatory protein, decay accelerating factor. Coronary artery thrombosis must now be added to the list of potential life-threatening thrombotic complications.
Klein
K L
KL
Department of Internal Medicine, University of South Florida College of Medicine, Tampa.
Hartmann
R C
RC
D000208:Acute Disease; D000328:Adult; D003327:Coronary Disease / Q000150:complications*; D003328:Coronary Thrombosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D013300:Streptokinase / Q000008:administration & dosage / Q000627:therapeutic use
D013300:Streptokinase