Endoarterial treatment of acute ischemia of the limbs with urokinase. Italian Cooperative Study "Bologna".
Authors report the results of the treatment of acute ischemia of the limbs with urokinase in patients included in a polycentric study group called "Bologna". A total of 111 patients affected with acute ischemias of the limbs caused by arterial or graft thromboses were treated with intra-arterial urokinase with a loading dose of 200,000 U.I., followed by 75,000 I.U./hour maintenance dose for 72 hours at the most. With this treatment 83.5% of clinically positive results was obtained. Complications and angiographic results are discussed.
D000208:Acute Disease; D001777:Blood Coagulation; D005121:Extremities / Q000098:blood supply*; D006801:Humans; D007269:Injections, Intra-Arterial; D007511:Ischemia / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D012008:Recurrence; D014568:Urokinase-Type Plasminogen Activator / Q000009:adverse effects / Q000627:therapeutic use*
D014568:Urokinase-Type Plasminogen Activator