Genetics and senescence. I. Age-related changes in activity and exploration in three inbred strains of mice.
Exploratory, locomotor and ambulatory activities were measured in nine independent groups of three inbred strains of mice (BALB/cBy, C57BL/6J and DBA/2J), at three different ages (150 days, 400 days and 750 days). The results show that for two of the three variables, the age-related changes present different patterns as a function of strain. The genetic and/or environmental correlates of the reactivity to aging may thus depend on the behavioral trait under study.
Laboratoire Génétique Neurogénétique et Comportement, URA 216 CNRS UER Biomédicale, Université Paris, France.
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Lhotellier
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Cohen-Salmon
D000375:Aging / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D008136:Longevity; D051379:Mice; D008807:Mice, Inbred BALB C / Q000502:physiology*; D008810:Mice, Inbred C57BL / Q000502:physiology*; D008811:Mice, Inbred DBA / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology*; D013045:Species Specificity