Inhibition of ischemic brain edema formation by post-ischemic administration of a prostaglandin oligomer.
We studied the efficacy of an oligomeric derivative of prostaglandin E1 in protecting the rat brain against focal ischemia. The degree of ischemic damage was evaluated from three parameters, namely, the degree of edema formation, reduction of motor performance, and memory disturbance as measured by a passive avoidance test. The pre-ischemic administration of the drug (6 mg/kg i.p.) had some effects, but the differences were not significant. The post-ischemic administration (6 mg/kg i.p.) produced significant improvement in all three parameters. The increase of water content of the ischemic hemisphere was reduced (p less than 0.05); the total motor score was improved (p less than 0.01); and the memory disturbance as estimated by the passive avoidance test was reduced (p less than 0.01). A possible mechanism of protection is discussed.
Membrane Research Institute, University City Science Center, Philadelphia, PA.
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Ohnishi
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Tominaga
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Katsuoka
D000527:Alprostadil / Q000031:analogs & derivatives*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001929:Brain Edema / Q000209:etiology / Q000517:prevention & control*; D002545:Brain Ischemia / Q000188:drug therapy*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011453:Prostaglandins; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011453:Prostaglandins; D011459:Prostaglandins E, Synthetic; C060276:MR 356; D000527:Alprostadil