Effect of anticancer agents neothramycin, aclacinomycin, FK-565 and FK-156 on the release of interleukin-2 and interleukin-1 in vitro.
Four anticancer agents, neothramycin, aclacinomycin, FK-565 and FK-156, were tested for their effects on concanavalin-A-induced interleukin-2 release from rat splenocytes in vitro. Neothramycin showed an enhancement of the release of interleukin-2, whereas aclacinomycin had no effect. FK-565 and FK-156 were found to inhibit the release of interleukin-2 under similar conditions. The inhibition was much more marked with FK-565. These drugs were also tested for their effects on the release of interleukin-1 from rat peritoneal exudate cells stimulated by lipopolysaccharide in vitro. Neothramycin and aclacinomycin did not affect the release of interleukin-1; however, both FK-565 and FK-156 resulted in its enhanced release under these conditions.
Department of Pathology, Royal College of Surgeons of England, London.
K
K
Ahmed
J L
JL
Turk
D015250:Aclarubicin / Q000031:analogs & derivatives / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology; D003960:Diaminopimelic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D007375:Interleukin-1 / Q000378:metabolism*; D007376:Interleukin-2 / Q000378:metabolism*; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000378:metabolism
D000276:Adjuvants, Immunologic; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D001570:Benzodiazepinones; D007375:Interleukin-1; D007376:Interleukin-2; D009842:Oligopeptides; C011157:aclacinomycins; D003960:Diaminopimelic Acid; C012453:neothramycins; D015250:Aclarubicin; C034330:FK 156; C039537:heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine