O-demethylation and N4-acetylation of sulphadimethoxine by the turtle Pseudemys scripta elegans.
After an oral dose of 350 mg of sulphadimethoxine, the turtle Pseudemys scripta elegans O-dealkylates sulphadimethoxine at the 2- and 6-position at 38% and 19% respectively, the 2-position being favoured. Acetylation of sulphadimethoxine and its hydroxy metabolites occurs for 57.4%.
Department of Clinical Pharmacy, Sint Radbound Hospital, Nijmegen, The Netherlands.
T B
TB
Vree
J B
JB
Vree
N
N
Beneken Kolmer
Y A
YA
Hekster
M
M
Shimoda
J F
JF
Nouws
T
T
Yoshioka
K
K
Hoji
D000107:Acetylation; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D013412:Sulfadimethoxine / Q000493:pharmacokinetics*; D014426:Turtles / Q000378:metabolism*
D013412:Sulfadimethoxine