[The mutagenic action of the DNA fragments of bovine adenovirus type 3 (BAV-3) containing early E1 (oncogene) and E4 regions].
A study of mutagenic action of DNA fragments of bovine adenovirus type 3 (BAV-3), containing early E1 (oncogenic) and E4 regions has been carried out. Viral DNA was digested with Xba 1 restriction endonuclease. The mutagenic effect revealed itself by induction of resistance to 6-mercaptopurine in Chinese hamster cells. The data obtained suggest that the early regions E1 and E4 can cause mutagenic effect in mammalian cells.
Charikova
E V
EV
D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D002417:Cattle; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004279:DNA, Viral / Q000235:genetics* / Q000302:isolation & purification; D004351:Drug Resistance; D005814:Genes, Viral; D015122:Mercaptopurine / Q000037:antagonists & inhibitors; D009154:Mutation; D009857:Oncogenes; D011401:Promoter Regions, Genetic
D004279:DNA, Viral; D015122:Mercaptopurine
Izuchenie mutagennogo deĭstviia fragmentov DNK bych'ego adenovirusa tipa 3 (BAV-3), soderzhashchikh rannie oblasti E1 (onkogen) i E4.