Elevated activity of myeloid growth factor in bone marrow adjacent to joints affected by rheumatoid arthritis.
Myeloid growth activity of rheumatoid arthritis (RA) and normal serum was measured with a newly developed simple method. Abnormally high titers of this activity were found in the bone marrow blood serum adjacent to joints with RA where abnormal myelopoiesis had been found. Maximal activity for myeloid growth was found at a molecular weight of 70 kDa in gel filtration of serum, different from the size of any known factors involved with myelopoiesis.
Department of Orthopedic Surgery, Osaka University Medical School, Japan.
H
H
Owaki
T
T
Ochi
K
K
Yamasaki
K
K
Yukawa
S
S
Wakitani
M
M
Okamura
K
K
Ono
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism*; D005260:Female; D006132:Growth Plate / Q000378:metabolism*; D006133:Growth Substances / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006801:Humans; D007596:Joints / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009504:Neutrophils / Q000378:metabolism
D006133:Growth Substances