Effects of anticholinergic drugs on regional brain neurotensin concentrations.
Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.
Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.
B
B
Levant
G
G
Bissette
C B
CB
Nemeroff
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects*; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009496:Neurotensin / Q000378:metabolism*; D010276:Parasympatholytics / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012601:Scopolamine / Q000494:pharmacology
D010276:Parasympatholytics; D009496:Neurotensin; D001285:Atropine; D012601:Scopolamine; D006220:Haloperidol