Prostaglandin derivatives inhibit the growth of malarial parasites in mice.
New prostaglandin oligomeric derivatives, termed MR-256 and MR-356, were found to inhibit the growth of murine malarial parasites, P. chabaudi and P. vinckei, within red blood cells in vivo. When mice were infected with P. chabaudi, both MR-256 and MR-356 suppressed the growth of parasites, but MR-356 had a greater inhibitory effect than MR-256. With P. vinckei, MR-356 also inhibited the growth of parasites, and improved the survival rate. The effect of MR-256 was much less. A possible inhibitory mechanism of action of these drugs is discussed.
Ohnishi
S T
ST
Membrane Research Institute, University City Science Center, Philadelphia, PA.
Ohnishi
N
N
Oda
Y
Y
Katsuoka
M
M
D000527:Alprostadil / Q000494:pharmacology* / Q000627:therapeutic use / Q000031:analogs & derivatives; D000818:Animals; D000962:Antimalarials; D007928:Lethal Dose 50; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D010961:Plasmodium / Q000187:drug effects* / Q000254:growth & development; D011453:Prostaglandins / Q000494:pharmacology; D011465:Prostaglandins, Synthetic / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
D000962:Antimalarials; D011453:Prostaglandins; D011465:Prostaglandins, Synthetic; C060277:MR 256; C060276:MR 356; D000527:Alprostadil