Ultrastructural correlates of functional relationships between nigral dopaminergic or cortical afferent fibers and neuropeptide Y-containing neurons in the rat striatum.
This study examines the ultrastructural relationships established by the nigrostriatal dopaminergic and the corticostriatal afferent fibers with neuropeptide Y (NPY)-containing neurons in the rat striatum. By means of dual immunolabeling procedures using peroxidase conjugated F(ab) fragments and 125I-labeled protein A, direct appositions and morphologically defined synaptic contacts of the symmetrical type were visualized between tyrosine hydroxylase-labeled nerve terminals and NPY-labeled neurons. After deafferentation of the striatum from its cortical input direct appositions and asymmetrical synaptic contacts were evidenced between characteristic degenerative boutons and NPY-positive neurons in the striatum. These results suggest that striatal NPY interneurons undergo direct influence from both nigrostriatal dopaminergic and corticostriatal neuronal systems.
Vuillet
J
J
Centre de Microscopie Electronique, Faculté de Médecine, Marseilles, France.
Kerkerian
L
L
Kachidian
P
P
Bosler
O
O
Nieoullon
A
A
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism* / Q000648:ultrastructure; D004298:Dopamine / Q000378:metabolism* / Q000502:physiology; D005260:Female; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009434:Neural Pathways / Q000378:metabolism; D009478:Neuropeptide Y / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000378:metabolism* / Q000648:ultrastructure
D009478:Neuropeptide Y; D004298:Dopamine