Red blood cell sodium-lithium countertransport, blood pressure, and uric acid metabolism in untreated healthy men.
The relationship of red blood cell (RBC) Na/Li countertransport to the renal handling of lithium and uric acid was investigated in a sample of 176 untreated men. Subjects in the upper quintile of the Na/Li countertransport distribution (n = 40), compared to those in the two lower quintiles (n = 72), had higher serum uric acid levels (0.34 +/- 0.06 v 0.29 +/- 0.05 mmol/L, P less than 0.001) and systolic blood pressure (131 +/- 19 v 123 +/- 16 mm Hg, P less than 0.02) and slightly lower fractional excretion of uric acid (7.5 +/- 1.5 v 8.4 +/- 2.6%, P less than 0.08). The lithium fractional excretion was not significantly related to either blood pressure or RBC Na/Li countertransport. The altered uric acid metabolism in individuals with high RBC Na/Li countertransport could be the expression of an abnormality of renal tubular function.
Institute of Internal Medicine and Metabolic Diseases, Clinica Medica, Second Medical School, University of Naples, Italy.
P
P
Strazzullo
F P
FP
Cappuccio
M
M
Trevisan
L
L
Iacoviello
R
R
Iacone
G
G
Barba
A
A
De Leo
E
E
Farinaro
M
M
Mancini
D001692:Biological Transport; D001794:Blood Pressure; D001824:Body Constitution; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D008094:Lithium / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D014527:Uric Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine
D014527:Uric Acid; D008094:Lithium; D012964:Sodium