The growth and cell kinetics of a secondary tumor after radiation or surgical treatment of the primary tumor.
Early transplants of a spontaneous mouse fibrosarcoma (FSa II) were used to investigate whether radiation or surgical treatment of a tumor in the leg altered the growth or cell kinetics of a second tumor in the axilla. The volume doubling times and in vivo Bromodeoxyuridine labeling indices of the axillary tumors were the same in the control group and in the groups which received 70 Gy to the leg tumor or normal leg. After surgical removal of the leg tumor, there was small reduction in the time to reach 1500 mm3 (4.0 vs 4.6 days) and an increase in Bromo-deoxyuridine labeling index at Day 3 (18% to 24%) in the axillary tumors. In all groups, there was a fall in labeling index with time reflecting increasing tumor size.
Dept. of Radiation Medicine, Massachusetts General Hospital, Harvard Medical School, Boston.
J
J
Ramsay
A
A
Zietman
F
F
Preffer
H D
HD
Suit
D000818:Animals; D001973:Bromodeoxyuridine; D002453:Cell Cycle; D002455:Cell Division; D005354:Fibrosarcoma / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D051379:Mice; D008809:Mice, Inbred C3H; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000473:pathology*
D001973:Bromodeoxyuridine