The progress of oesophageal involvement in progressive systemic sclerosis during D-penicillamine treatment.
In 21 patients with initial signs of progressive systemic sclerosis, oesophageal motility was monitored manometrically from the start of D-penicillamine treatment and over a period of up to 5 years. Urinary excretion of the collagen-specific amino acids hydroxyproline and hydroxylysine, and of proline was used as a guideline for monitoring the bioavailability of D-penicillamine. D-penicillamine therapy was found to be unable to arrest the progress of oesophageal involvement. A downward trend over time--statistically significant at p = 0.03, p = 0.02, and p less than 0.005--was found for lower oesophageal sphincter pressure, peristaltic wave pressure in the distal third, and peristaltic wave pressure in the middle third of the oesophagus, respectively.
Hendel
L
L
Department of Dermatology, Rigshospital, Copenhagen, Denmark.
Stentoft
P
P
Aggestrup
S
S
D004941:Esophagitis / Q000209:etiology; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology; D006801:Humans; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use*; D010528:Peristalsis; D011446:Prospective Studies; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*
D010396:Penicillamine