Ethanol and water sorption into stratum corneum and model systems.
Sorption of ethanol and water into stratum corneum, delipidized stratum corneum, and triolein as a simple model lipid was investigated. Optima in ethanol sorption and flux are related to dehydration of keratins. There was no optimum for solubility in triolein; a linear cosolvency is observed with ethanol:triolein mixtures. A model is proposed which qualitatively predicts the key features of ethanol-enhanced skin permeation on the basis of these solubility phenomena and a constant diffusion coefficient.
CIBA-GEIGY Corporation, Ardsley, N.Y. 10502.
B
B
Berner
R H
RH
Juang
G C
GC
Mazzenga
D000431:Ethanol / Q000493:pharmacokinetics*; D006801:Humans; D066298:In Vitro Techniques; D008055:Lipids / Q000502:physiology; D008297:Male; D008954:Models, Biological; D012869:Skin Absorption; D012995:Solubility; D014304:Triolein / Q000032:analysis; D014783:Viscosity; D014867:Water
D008055:Lipids; D014867:Water; D014304:Triolein; D000431:Ethanol