Inhibition of monoamine oxidase by the fungicide metalaxyl.
The in vitro effect of metalaxyl on monoamine oxidase (MAO) activity in rat heart was studied. Metalaxyl decreased MAO activity in a dose-dependent manner. The inhibitory concentration (IC50) for metalaxyl was found to be 19 mumol. Substrate-dependent kinetic studies demonstrated noncompetitive inhibition as evidenced by decreased velocity of enzyme activity (Vmax) without significant change in enzyme-substrate affinity (Km). The inhibition of MAO activity by metalaxyl suggests interference with amine metabolism.
Nutrition and Food Safety, Central Food Technological Research Institute, Mysore, India.
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D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D005659:Fungicides, Industrial / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D005659:Fungicides, Industrial; D008996:Monoamine Oxidase Inhibitors; C028175:metalaxyl; D000409:Alanine