Use of cisplatin for control of metastatic malignant mesenchymoma and hypertrophic osteopathy in a dog.
Cisplatin (cis-diammine-dichloroplatinum) treatment induced partial remission of pulmonary metastatic malignant mesenchymoma and nearly complete radiographic remission of hypertrophic osteopathy in a 14-year-old Beagle. Cisplatin was given once every 3 weeks. Clinical signs of hypertrophic osteopathy resolved one week after initiation of treatment. Partial remission of pulmonary metastases and partial radiographic remission of hypertrophic osteopathy was seen 6 weeks after initiation of treatment. Previous treatment of neoplasia-related hypertrophic osteopathy has consisted of removal of the initiating mass or vagotomy. In this case, appropriate chemotherapy was used to control clinical signs and progression of hypertrophic osteopathy.
Hahn
K A
KA
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-7403.
Richardson
R C
RC
D000818:Animals; D001847:Bone Diseases / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D002945:Cisplatin / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D006984:Hypertrophy; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000662:veterinary*; D008637:Mesenchymoma / Q000150:complications / Q000188:drug therapy / Q000556:secondary / Q000662:veterinary*; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy / Q000662:veterinary; D012983:Soft Tissue Neoplasms / Q000150:complications / Q000188:drug therapy / Q000662:veterinary
D002945:Cisplatin