The value of C-reactive protein in the diagnosis of intestinal perforation in typhoid fever.
Serum C-reactive protein concentrations were measured in 28 Nigerian patients with typhoid fever on presentation at hospital and at intervals thereafter. Five of the 28 (18%) were subsequently diagnosed as suffering from ileal perforation. These patients had concentrations of C-reactive protein during the first 24 h of admission which were significantly higher (mean = 229 mg/L) than those without perforation (mean = 91 mg/L). C-reactive protein may have a role in the prediction of early diagnosis of perforation in patients with typhoid fever.
Olubuyide
I O
IO
Department of Medicine, University College Hospital, Ibadan, Nigeria.
Brown
N M
NM
Higginson
J
J
Whicher
J T
JT
D002097:C-Reactive Protein / Q000097:blood*; D006801:Humans; D007416:Intestinal Perforation / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors; D014435:Typhoid Fever / Q000097:blood / Q000150:complications* / Q000503:physiopathology
D002097:C-Reactive Protein