Superwarfarin poisoning in children: a prospective study.
This prospective study was undertaken to determine the incidence, severity, time of onset, and duration of coagulopathy in children following accidental ingestion of long-acting anticoagulant rodenticides, often called "superwarfarins." Of 110 children, who ingested superwarfarins and in whom one or more prothrombin time values were obtained, 8 had a prothrombin time ratio (patient to control) of greater than or equal to 1.2, indicative of anticoagulation. Prothrombin time values obtained 48 hours after ingestion were more likely to be prolonged (6/34, 17.6%) than values obtained 24 hours after ingestion (2/104, 1.9%) (P less than .005). The occurrence of an abnormal prothrombin time could not be predicted based on the history of amount ingested or on the presence of the characteristic green-blue product dye in or around the child's mouth. Acute toxicity was evidenced by transient abdominal pain, vomiting, and heme positive stools in 2 patients. The duration of prothrombin time prolongation could not be determined because of the few values obtained after 48 hours. To detect all possible abnormal prothrombin time values, 24- and 48-hour determinations are recommended after a child has ingested a superwarfarin.
Smolinske
S C
SC
Rocky Mountain Poison and Drug Center, Denver, CO 80204-4507.
Scherger
D L
DL
Kearns
P S
PS
Wruk
K M
KM
Kulig
K W
KW
Rumack
B H
BH
D015110:4-Hydroxycoumarins / Q000506:poisoning*; D000925:Anticoagulants / Q000506:poisoning; D001778:Blood Coagulation Disorders / Q000139:chemically induced* / Q000503:physiopathology; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D011446:Prospective Studies; D011517:Prothrombin Time; D012378:Rodenticides / Q000506:poisoning*; D013997:Time Factors
D015110:4-Hydroxycoumarins; D000925:Anticoagulants; D012378:Rodenticides; C013418:bromfenacoum; C012903:difenacoum