Monosynaptic nigral inputs to the pedunculopontine tegmental nucleus neurons which send their axons to the medial reticular formation in the medulla oblongata. An electron microscopic study in the cat.
An electron microscopic study in the cat has suggested that neurons in the substantia nigra pars reticulata (SNr) project to the medial reticular formation of the medulla oblongata (MRF) via the pedunculopontine tegmental nucleus (PPN): PPN neurons, which were labeled with a retrograde tracer (WGA-HRP; horseradish peroxidase conjugated to wheat germ agglutinin) injected into the MRF, were found to be in synaptic contact with axon terminals which were degenerated with neurotoxic agents applied into the SNr.
Nakamura
Y
Y
Department of Anatomy, School of Medicine, Kanazawa University, Japan.
Tokuno
H
H
Moriizumi
T
T
Kitao
Y
Y
Kudo
M
M
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D002415:Cats; D006651:Histocytochemistry; D007051:Ibotenic Acid / Q000494:pharmacology; D008526:Medulla Oblongata / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D009498:Neurotoxins / Q000494:pharmacology; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D013681:Tegmentum Mesencephali / Q000648:ultrastructure*
D009498:Neurotoxins; D007051:Ibotenic Acid