Effects of dietary restriction on radial-arm maze performance and flavor memory in aged rats.
Two groups of aged rats, a dietary restricted group fed approximately 10 g per day from 6 weeks of age and a group fed ad lib throughout their life span, were compared with a young adult group on an 8-arm radial maze and a flavor memory task. The young adult displayed efficient performance on the radial-arm maze within the 15 day test period. In contrast, both aged groups exhibited significantly poorer performance in the maze in comparison with the young adult group neither aged group differed from chance at the end of the 15 days. The flavor memory task required the animals to consume a novel flavor. Their loss of neophobia, as indexed by their subsequent consumption, was then taken as an indication of the extent to which they remembered the novel flavor and its effects. The young adult group lost their neophobia more rapidly than either of the aged groups, which did not appear to differ from each other. Taken together, this pattern of results indicates that dietary restriction does not protect animals from the memory loss observed in aged animals.
School of Behavioural Sciences, Macquarie University, Sydney, NSW, Australia.
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Bond
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Everitt
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Walton
D000818:Animals; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders; D009483:Neuropsychological Tests; D010698:Phobic Disorders / Q000503:physiopathology; D011597:Psychomotor Performance / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000502:physiology*