[Effect of alpha-tocopherol combined with finoptin on the level of lipid hydroperoxides in plasma lipoproteins and on the functional activity of thrombocytes in patients with exertion-induced stable stenocardia].
Thirty three patients with stable effort-associated angina (Functional Class II) were examined. Enhanced lipid hydroperoxide levels in plasma lipids from the patients were found to play a pathogenetic role in the disturbance of platelet microcirculatory homeostasis. The calcium antagonist finoptin used in combination with alpha-tocopherol made it possible to decrease lipid hydroperoxide levels in low density lipoproteins and malondialdehyde concentrations in platelets, to prevent abnormal cyclic nucleotide metabolism in them and to increase tolerance to physical exercise.
V A
VA
Levchenklo
I P
IP
Gereliuk
N N
NN
Serediuk
I P
IP
Vakaliuk
M N
MN
Boklashchuk
D000328:Adult; D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood*; D008054:Lipid Peroxides / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D010974:Platelet Aggregation / Q000187:drug effects*; D014700:Verapamil / Q000008:administration & dosage*; D014810:Vitamin E / Q000008:administration & dosage*
D002121:Calcium Channel Blockers; D008054:Lipid Peroxides; D008074:Lipoproteins; D014810:Vitamin E; D006861:Hydrogen Peroxide; D014700:Verapamil
Vliianie alpha-tokoferola v sochetanii s finoptinom na soderzhanie gidroperekiseĭ lipidov v lipoproteidakh plazmy i funktsiona'lnuiu vnost trombotsitov u bo'lnykh so stabi'lnoĭ stenokardieĭ napriazhen