Familial aortic valve disease: evidence for a genetic influence?
It has been suggested that genetic factors may play a role in the aetiology of congenital bicuspid aortic valve disease. This report describes a family in which three male siblings with bicuspid aortic valves developed critical aortic stenosis. This provides further evidence that an hereditary mechanism may play a role in some patients with this condition.
St Vincent's Hospital, University College Dublin, Ireland.
K
K
McDonald
B J
BJ
Maurer
D000328:Adult; D001021:Aortic Valve; D001024:Aortic Valve Stenosis / Q000209:etiology; D030342:Genetic Diseases, Inborn / Q000209:etiology*; D006349:Heart Valve Diseases / Q000150:complications / Q000151:congenital / Q000209:etiology*; D006801:Humans; D008297:Male