Caudato-nigral transmission in the substantia nigra pars reticulata neurons changes with recovery from circling movements induced by microinfusion of ibotenic acid. II. Electrophysiological study on synaptic transmission.
Caudato-nigral synaptic transmission was examined by stimulation of the caudate nucleus while recording from nigral neurons in cats recovering from circling movements induced by a unilateral circumscribed lesion in the substantia nigra pars reticulata after microinfusion of ibotenic acid. Extra- and intracellular recording from neurons in lesion-spared areas of the substantia nigra pars reticulata indicated that the caudato-nigral synaptic action on the side ipsilateral to the lesion exhibited a shorter duration of inhibition and a larger amplitude of excitation as a means of compensating for the circling movements.
Udo
M
M
Division of Neuromuscular Skills, Faculty of Health and Sport Sciences, Osaka University, Japan.
Shimada
T
T
Hirose
S
S
Kitamura
T
T
Yamamoto
H
H
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D007051:Ibotenic Acid / Q000633:toxicity*; D009498:Neurotoxins / Q000494:pharmacology; D010080:Oxazoles / Q000633:toxicity*; D010852:Picrotoxin / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology*; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*
D007051:Ibotenic Acid; D009498:Neurotoxins; D010080:Oxazoles; D010852:Picrotoxin