Long-term follow-up of membranoproliferative glomerulonephritis type II and pregnancy: a case report.
A 24-year-old female was diagnosed as having membranoproliferative glomerulonephritis type II (or dense deposit disease), 11 years prior to becoming pregnant. The patient's first renal biopsy was performed 5 years after the onset of her renal symptoms. This biopsy was compared to a second renal biopsy taken just before the patient became pregnant. The second renal biopsy only showed a slight progression in the disease process. During the course of pregnancy, neither renal insufficiency nor hypertension were clinically evident. However, both an increase in proteinuria and a transient hypoalbuminemia were observed. The pregnancy, labor and delivery, and postpartum course for both the mother and child were without complications. Cases of membranoproliferative glomerulonephritis type I and pregnancy have been reported. However, to our knowledge, there are few reports documenting the outcome of pregnancy when a patient has membranoproliferative glomerulonephritis type II. We suggest that it is possible for a patient with membranoproliferative glomerulonephritis type II to have an uneventful pregnancy if she has neither hypertension nor renal insufficiency.
Inaba
S
S
Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Tanizawa
T
T
Igarashi
T
T
Higuchi
A
A
Satou
H
H
Mase
D
D
Asada
R
R
Suzuki
Y
Y
Okada
T
T
D000328:Adult; D001485:Basement Membrane / Q000648:ultrastructure; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D015432:Glomerulonephritis, Membranoproliferative / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D008854:Microscopy, Electron; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D013997:Time Factors