Heterogeneous activation of protein kinase C during rat liver regeneration induced by carbon tetrachloride administration.
During rat liver regeneration induced by carbon tetrachloride administration, the protein kinase C alpha subspecies was activated in a heterogeneous fashion, a higher number of hepatocytes expressing the protein kinase C alpha subspecies being detected in the pericentral zone than in the periportal zone. This zonal heterogeneity became maximal at 24 h after the treatment. The distribution of hepatocytes expressing the protein kinase C alpha subspecies was roughly coincident with that of hepatocytes exhibiting DNA synthesis. These results suggest that protein kinase C may play a crucial role in liver regeneration.
Sasaki
Y
Y
First Department of Medicine, Osaka University Medical School, Japan.
Hayashi
N
N
Ito
T
T
Fusamoto
H
H
Sato
N
N
Kamada
T
T
D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D004261:DNA Replication / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D007150:Immunohistochemistry; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D008115:Liver Regeneration; D008297:Male; D008954:Models, Biological; D011493:Protein Kinase C / Q000302:isolation & purification / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D002251:Carbon Tetrachloride; D011493:Protein Kinase C