Relapse rates in moderately severe chronic psoriasis treated with cyclosporin A.
Seventeen patients with chronic psoriasis were given cyclosporin A (CsA) 5 mg/kg per day. Twelve patients cleared within 3 months and their relapse rate, 41% at 6 months, was not significantly different from that previously reported with dithranol or PUVA. This pilot study also suggests that continuing CsA for up to 4 weeks after clinical clearance confers no advantage with regard to relapse. Significant adverse effects on renal function and blood pressure did not occur.
University Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
E
E
Higgins
C
C
Munro
J
J
Marks
P S
PS
Friedmann
S
S
Shuster
D000328:Adult; D002908:Chronic Disease; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012008:Recurrence
D003524:Cyclosporins