Identification of octadeca-9,11-dienoic acid and its significance in the diagnosis of cervical intraepithelial neoplasia.
In 1987 it was claimed using high performance liquid chromatography (HPLC) that the molar ratio of octadeca-9,11-dienoic acid to its parent linoleic acid (18:2 (9,12)) was raised in malignant and premalignant conditions of the cervix. In this study based on a gas chromatographic procedure which prevents autoxidation and avoids the detection limitations of HPLC, we have shown that assay of these fatty acids has no role to play in the assessment of cervical neoplasia.
Parham
D M
DM
Department of Pathology, University of Dundee, Scotland, UK.
Ross
P E
PE
Gunstone
F D
FD
Robertson
A J
AJ
Duncan
I D
ID
D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004910:Erythrocyte Membrane / Q000032:analysis; D005260:Female; D006801:Humans; D007536:Isomerism; D008041:Linoleic Acids / Q000032:analysis*; D044243:Linoleic Acids, Conjugated; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D014626:Vaginal Smears
D008041:Linoleic Acids; D044243:Linoleic Acids, Conjugated; C046938:9,11-linoleic acid