Acute haemodynamic effects of ibopamine and dopamine on isovolumic relaxation.
The effects of intraduodenal ibopamine (a new orally active inotropic agent claimed to have haemodynamic effects similar to dopamine) on isovolumic relaxation were monitored for 90 min in eight closed-chest anaesthetized dogs. Dopamine and epinine (ibopamine active metabolite) were also infused at graded doses. After 15 min, ibopamine (12 mg/kg) shortened the time constant of isovolumic relaxation, and increased stroke volume and mean aortic pressure. Peak positive dP/dt increased significantly only 10 min later. Heart rate did not change. Dopamine (10 micrograms/kg per min) similarly reduced the time constant, and increased stroke volume, mean aortic pressure, peak positive dP/dt and heart rate. Epinine (10 micrograms/kg per min) caused similar changes in peak positive dP/dt, stroke volume, mean aortic pressure, and accelerated time constant without raising the heart rate. Ibopamine and epinine therefore significantly improved the isovolumic relaxation phase, like dopamine, without however affecting the heart rate.
Department of Internal Medicine, University of Pavia, IRCCS, San Matteo, Italy.
L
L
Bernardi
S
S
Perlini
F
F
Soffiantino
C
C
Farilla
A
A
Calciati
P L
PL
Soldá
M
M
Paro
L
L
Merlo
G
G
Marchetti
G
G
Finardi
D000818:Animals; D003846:Deoxyepinephrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004285:Dogs; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; C023487:ibopamine; D003846:Deoxyepinephrine; D004298:Dopamine