Prophylactic one-dose treatment with clindamycin and gentamicin in transurethral prostatic resection. A double-blind placebo controlled study.
One hundred and sixty-eight patients scheduled for transurethral prostatic resection were randomly assigned to treatment either with a combination of clindamycin and gentamycin or with placebo, administered preoperatively as a single bolus infusion. The patients were stratified into a group of 35 with preoperative bacteriuria, and a group of 133 with preoperative sterile urine. Postoperatively the frequency of bacteriuria and bacteriaemia, the maximum body temperature measured, the number of patients with antibiotic therapy instituted, and the duration of hospitalization were significantly lower in the treated than in the placebo group. This applied both to the group with preoperative sterile urine and to the group with preoperative bacteriuria.
Kjaergaard
B
B
Department of Surgery, Brønderslev Hospital, Denmark.
Petersen
E
E
Lauridsen
K G
KG
Petersen
A S
AS
D000368:Aged; D001437:Bacteriuria / Q000517:prevention & control; D002981:Clindamycin / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D007902:Length of Stay; D008297:Male; D011292:Premedication; D011468:Prostatectomy; D011897:Random Allocation; D018805:Sepsis / Q000517:prevention & control; D012768:Shivering / Q000187:drug effects
D005839:Gentamicins; D002981:Clindamycin