[Mechanism of activating the lymphocyte glucocorticoid receptor in acute myocardial infarct].
Dose-dependent increase in content of highly specific binding sites for glucocorticoids (receptors), but without alteration in their affinity to the hormone, was observed after incubation during 2 hrs of healthy donor lymphocytes with blood serum of patients with acute myocardial infarction. The similar effects exhibited protein extracts of necrotized and normal parts of human myocardium (heart antigens) as well as the autologous blood serum and human blood serum albumin treated with UV-irradiation. Number of receptors was not altered in human skin fibroblasts incubated both with the patients blood serum and with the UV-treated blood serum. Antigenic effects of protein components, developed in blood serum after acute myocardial infarction, on cells of the lymphoid system appear to be responsible for the increase in number of binding sites for glucocorticoids in lymphocytes of patients with acute myocardial infarction or in lymphocytes of healthy donors incubated with the patients blood serum.
I E
IE
Petrichenko
A Sh
ASh
Shartava
Iu A
IuA
Shakhov
D000328:Adult; D003907:Dexamethasone / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*
D011965:Receptors, Glucocorticoid; D003907:Dexamethasone
O mekhanizme aktivatsii gliukokortikoid-retseptornogo apparata limfotsitov pri ostrom infarkte miokarda.