[Biosynthesis of 14C-macrocyclic trichothecenes].
Possibility of producing (14C)-macrocyclic trichothecenes (MCTC) with high specific activity was studied. (1-14C)-glucose, (2-14C)-acetate and (2-14C)-mevalonate were used as precursors. The best results were obtained when labeled acetate was introduced into the medium at the end of the logarithmic growth stage of Dendrodochium toxicum 5800, a fungus-producer. Individual (14C)-MCTC with high specific activity are obtained: verrucarine A-158.1 microC/mM, rhoridine A-167.4 microC/mM; rhoridine H-161.9 microC/mM.
A M
AM
Zaĭchenko
T I
TI
Tugaĭ
V V
VV
Shliakhovoĭ
D055598:Chemical Phenomena; D002621:Chemistry; D003904:Mitosporic Fungi / Q000378:metabolism*; D012717:Sesquiterpenes / Q000096:biosynthesis*; D014255:Trichothecenes / Q000096:biosynthesis* / Q000378:metabolism
D012717:Sesquiterpenes; D014255:Trichothecenes
Biosintez 14C-makrotsiklicheskikh trikhotetsenov.