Effects of mammal submandibular gland glycoderivatives on human hemostatic system.
The aim of this study was to investigate the effects of glycoconjugate components extracted from the submandibular glands of four mammal species (rat, mouse, rabbit, hare) on human hemostatic system. The following analyses were performed: thromboelastography and hemocoagulation screening tests (Thrombin Time, Prothrombin Time, Partial Thromboplastin Time). Findings showed that all glycoconjugates induce modifications of fibrin clot formation time, modulus of elasticity and some hemocoagulation tests (TT, PTT). The anticoagulant effects were of inhibitory type.
Menghi
G
G
Lai
G
G
Piciotti
D
D
Ravaglia
F
F
D000818:Animals; D000925:Anticoagulants; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D005337:Fibrin / Q000378:metabolism; D006001:Glycoconjugates / Q000494:pharmacology*; D006493:Heparin / Q000378:metabolism; D006801:Humans; D051379:Mice; D011817:Rabbits; D051381:Rats; D013363:Submandibular Gland / Q000032:analysis*; D013916:Thrombelastography; D013997:Time Factors
D000925:Anticoagulants; D006001:Glycoconjugates; D005337:Fibrin; D006493:Heparin