A rapid method for estimating mean platelet survival time.
Platelet survival studies were performed in 27 consecutive subjects, and mean platelet life span was derived by computerized calculations of radioactivity in blood samples obtained daily for 9-11 days. These computer derived estimates were then correlated with the raw whole blood radioactivity data obtained for the first 3 days of each study. Data from the 48-hr point correlates with the computer estimates so that platelet survival data can now be reported in 2 days with 93% precision of the long method and without visual curve fitting. Thus, one may take a "quick look" at the probable platelet lifespan, under steady state conditions, in order to evaluate therapy while avoiding problems of patient compliance.
Monte-Scaglione Memorial Laboratory, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark.
D C
DC
Giuliani
E H
EH
Ford
B S
BS
Morse
D001792:Blood Platelets / Q000502:physiology*; D001807:Blood Vessel Prosthesis; D002470:Cell Survival; D006801:Humans; D007205:Indium Radioisotopes; D011696:Purpura, Thrombocytopenic / Q000097:blood; D012016:Reference Values; D012044:Regression Analysis; D012984:Software; D013163:Splenomegaly / Q000097:blood
D007205:Indium Radioisotopes