Plasma tocopherol in sheep and cattle after ingesting free or acetylated tocopherol.
Two trials were carried out to evaluate the bioavailability of dl-alpha-tocopherol and dl-alpha-tocopherol acetate administered to sheep and cattle in a single oral dose. In the first trial, two groups of five sheep were used. They received 100 mg/kg body weight of either dl-alpha-tocopherol or its acetylated form. The blood plasma alpha-tocopherol tolerance curve area was higher in the dl-alpha-tocopherol group than in its ester form. The time to reach maximum plasma alpha-tocopherol concentration was less in the dl-alpha-tocopherol group than in its ester form. In a second trial, four heifers received the two forms (50 mg/kg body weight) in rotation after an appropriate washing period between the two dosings. Again, plasma tolerance curve area was greater in the cattle following administration of dl-alpha-tocopherol than its acetylated form.
Hidiroglou
N
N
Animal Science Department, University of Florida, Gainesville 32611-0691.
McDowell
L R
LR
Balbuena
O
O
D000818:Animals; D001682:Biological Availability; D002417:Cattle / Q000378:metabolism*; D005260:Female; D008297:Male; D012756:Sheep / Q000378:metabolism*; D024505:Tocopherols; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood* / Q000493:pharmacokinetics; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols