The distribution of intravenous nicardipine in rat brain after subarachnoid hemorrhage.
The distribution of intravenously injected nicardipine in rat brain was investigated, as well as the influence of subarachnoid hemorrhage on its distribution. Autoradiographic studies demonstrated the accumulation of 3H-nicardipine only in the ventricles and subarachnoid spaces around pial vessels in normal brains. Thirty minutes after subarachnoid hemorrhage, the concentration of 3H-nicardipine was higher in the ventricles and in the subarachnoid space than that found in normal brains. It is concluded that nicardipine penetrates into the subarachnoid spaces and ventricles from pial vessels and/or choroid plexus, and that subarachnoid hemorrhage increases the penetration of nicardipine from vessels into the subarachnoid space.
Tsukahara
T
T
Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville 22908.
Arista
A
A
Kassell
N F
NF
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D007275:Injections, Intravenous; D008297:Male; D009529:Nicardipine / Q000097:blood / Q000493:pharmacokinetics*; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D013345:Subarachnoid Hemorrhage / Q000097:blood / Q000378:metabolism*; D014018:Tissue Distribution; D014316:Tritium
D014316:Tritium; D009529:Nicardipine