Chromosome 22 abnormalities in Ewing's sarcoma.
A child with disseminated Ewing's sarcoma underwent cytogenetic investigations which showed different structural rearrangements of chromosome 22 at diagnosis (?ring22), and at relapse [t(10;22)], but the classic translocation t(11;22) was not detectable. This case provides further evidence of the importance of chromosome 22 in this disease, while raising some questions about the central importance of the translocation between chromosomes 11 and 22.
Department of Human Genetics, University of Newcastle upon Tyne.
E V
EV
Davison
A D
AD
Pearson
J
J
Emslie
M M
MM
Reid
A
A
Malcolm
A W
AW
Craft
D001859:Bone Neoplasms / Q000150:complications / Q000235:genetics; D002648:Child; D002869:Chromosome Aberrations / Q000150:complications*; D025063:Chromosome Disorders; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007085:Ilium; D007621:Karyotyping; D012512:Sarcoma, Ewing / Q000150:complications / Q000235:genetics*; D014178:Translocation, Genetic