Gastrointestinal transit times of a charcoal/sorbitol slurry in overdose patients.
Gut decontamination with a slurry of activated charcoal and sorbitol is one of the methods presently available to decrease total body burden of ingested drug. This one year retrospective audit of patients presenting with a history of recent toxic ingestion was designed to determine the time to stool of a charcoal/sorbitol slurry (CSS) when used for differing ingestants. A total of 69 patients received a CSS. 50.7% took less than 6 hours for their first charcoal stool, while 26.1% had emesis of the CSS within 30 minutes of administration. Ingestion of drugs which may increase gastrointestinal transit time (i.e. opioids, cyclic antidepressants) correlated with prolonged time to stool despite treatment with the CSS. Though a prospective, controlled study needs to be performed, variation in dosage of the CSS may be appropriate in select patient groups to offset the effects of the ingestant on bowel motility.
Harchelroad
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F
Division of Emergency Medicine, Allegheny General Hospital, Pittsburgh, PA 15212.
Cottington
E
E
Krenzelok
E P
EP
D000293:Adolescent; D000328:Adult; D002606:Charcoal / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D011041:Poisoning / Q000378:metabolism / Q000628:therapy*; D012189:Retrospective Studies; D013012:Sorbitol / Q000493:pharmacokinetics / Q000627:therapeutic use*
D002606:Charcoal; D013012:Sorbitol