Occurrence of tetrodotoxin in the frog Atelopus oxyrhynchus.
Alcohol extracts from the frog Atelopus oxyrhynchus were toxic to mice when injected intraperitoneally. The toxin was purified by gel filtration on a Sephadex G-15 column, and was identified as tetrodotoxin by thin-layer chromatography and GC-MS analysis of the alkali-hydrolyzed and trimethylsilylated derivative giving the same pattern as the C9-base of tetrodotoxin.
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Zentrum der Rechtsmedizin, University of Frankfurt, Federal Republic of Germany.
Schmidt
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D000818:Animals; D001001:Anura / Q000378:metabolism*; D002850:Chromatography, Gel; D008401:Gas Chromatography-Mass Spectrometry; D051379:Mice; D013779:Tetrodotoxin / Q000032:analysis* / Q000302:isolation & purification / Q000633:toxicity; D014687:Venezuela
D013779:Tetrodotoxin