Tumor-associated erythrocytosis in a dog with nasal fibrosarcoma.
Erythrocytosis (hematocrit, 79%) was diagnosed in an 8-year-old, neutered female, mixed-breed dog with an intranasal fibrosarcoma. Both serum and tumor erythropoietin (Ep) activities were elevated, as determined by the polycythemic exhypoxic mouse model, and the Ep activity was neutralized in that model by rabbit anti-Ep antibodies. Tumor resection normalized the hematocrit.
Couto
C G
CG
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus.
Boudrieau
R J
RJ
Zanjani
E D
ED
D000818:Animals; D004283:Dog Diseases / Q000378:metabolism; D004285:Dogs; D004921:Erythropoietin / Q000032:analysis / Q000096:biosynthesis / Q000097:blood; D005260:Female; D005354:Fibrosarcoma / Q000150:complications / Q000378:metabolism / Q000662:veterinary*; D009669:Nose Neoplasms / Q000150:complications / Q000378:metabolism / Q000662:veterinary*; D011086:Polycythemia / Q000209:etiology / Q000662:veterinary*
D004921:Erythropoietin