omega-Hydroxyacid derivatives in the epidermis of several mammalian species.
1. omega-Hydroxyacids from the acylceramides and acylglucosylceramides of mammalian epidermis were examined by thin-layer and gas-liquid chromatography to determine their degree of unsaturation and chain-length distributions. The species examined included human (Homo sapiens), pig (Sus scrofa), mouse (Mus musculus) and rat (Rattus rattus). 2. Within a species, the omega-hydroxyacids from the acylceramide and acylglucosylceramide were essentially identical. 3. The human omega-hydroxyacids proved to be mainly saturated with C30:0 being the major entity. 4. The pig contained similar saturated, monoenoic and small amounts of dienoic omega-hydroxyacids, with C30:0, C32:1 being the major entities. 5. The mouse and rat contained C32:0 and C34:1 as the major components.
Department of Dermatology, University of Iowa College of Medicine, Iowa City 52242.
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Wertz
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Downing
D000818:Animals; D002518:Ceramides / Q000032:analysis; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004817:Epidermis / Q000032:analysis*; D005963:Glucosylceramides / Q000032:analysis; D006801:Humans; D006880:Hydroxy Acids / Q000032:analysis*; D013058:Mass Spectrometry; D051379:Mice; D015394:Molecular Structure; D008970:Molecular Weight; D051381:Rats; D013045:Species Specificity; D013552:Swine
D002518:Ceramides; D005963:Glucosylceramides; D006880:Hydroxy Acids