The determination of microscopic ionization constants of a substituted piperazine using estimates from model compounds.
The microscopic ionization constants of 1-[3-(4-chlorophenyl) propyl] piperazine (I) were determined using piperazine (P) and 1,4-bis[3-(4-chlorophenyl)propyl] piperazine (II) as models for one of the ionizations. The macroscopic ionization constants for all three compounds were measured potentiometrically, and the micro constants of P and II, which are symmetrical molecules, were calculated from their macro constants. Only one micro constant of either P or II was suitable as a model for elucidating the micro constants of I.
Pharmaceutics Department, Boehringer Ingelheim Pharmaceuticals Inc. Ridgefield, Connecticut 06877.
N K
NK
Pandit
J M
JM
Sisco
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007477:Ions; D008433:Mathematics; D000432:Methanol; D008956:Models, Chemical; D010879:Piperazines; D011199:Potentiometry; D014867:Water
D007477:Ions; D010879:Piperazines; D014867:Water; C060664:1,4-bis(3-(4-chlorophenyl)propyl)piperazine; C060663:1-(3-(4-chlorophenyl)propyl)piperazine; D000432:Methanol