Topical treatment of severe corneal ulcers with cyclosporin A.
Cyclosporin A eye drops were used on six patients to treat corneal ulcers associated with rheumatic diseases, oculomucocutaneous syndrome, and Sjögren's syndrome. Conjunctival excision was additionally carried out in two cases. All ulcers healed rapidly. The mechanism of ulcer formation involving T-lymphocytes is discussed.
Zierhut
M
M
Augenklinik der Universität, Tübingen, Federal Republic of Germany.
Thiel
H J
HJ
Weidle
E G
EG
Waetjen
R
R
Pleyer
U
U
D000287:Administration, Topical; D000293:Adolescent; D000368:Aged; D003228:Conjunctiva / Q000473:pathology; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000276:immunology; D003524:Cyclosporins / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012216:Rheumatic Diseases / Q000473:pathology
D003524:Cyclosporins