Bright white light does not improve narcoleptic symptoms.
Bright white light (500lx) for 4 h/day was applied to seven narcoleptic patients (age 47-65 years, mean 55 years). The effects of the light on the disturbed sleep-wake cycle in narcoleptics were investigated by the measurement of the following parameters: (1) excessive daytime sleepiness and sustained attention (multiple sleep latency test); (2) rest-activity cycles; (3) self-ratings (mood, anxiety, tiredness); (4) urinary cycles of 6-OH melatonin sulphate and cortisol; (5) sleep EEG. Treatment with bright light showed neither objective nor subjective changes in the clinical symptoms of narcolepsy. While similar "dosage" light applications can phase shift human circadian rhythms and improve depression and hypersomnia in winter depression, it is not an appropriate treatment for narcolepsy.
Neurological Hospital, Schwalmstadt-Treysa, Federal Republic of Germany.
M
M
Hajek
K
K
Meier-Ewert
A
A
Wirz-Justice
I
I
Tobler
J
J
Arendt
H
H
Dick
G
G
Fink
D000368:Aged; D002940:Circadian Rhythm / Q000528:radiation effects; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives / Q000652:urine; D008875:Middle Aged; D009290:Narcolepsy / Q000628:therapy*; D010789:Phototherapy; D012894:Sleep Stages / Q000528:radiation effects
C054513:6-sulfatoxymelatonin; D008550:Melatonin; D006854:Hydrocortisone