inv(12)(p11.2q13) in an endometrial polyp.
A benign endometrial polyp from a 50-year-old postmenopausal woman has been cytogenetically investigated. A single clonal karyotypic anomaly, inv(12)(p11.2q13), was found in about 30% of cells analyzed after short-term culture. This finding contributes further to the hypothesis that the chromosomal segment 12q13-q14, which is also involved in chromosomal rearrangements in uterine leiomyomas, pleomorphic adenomas of the salivary glands, lipomas, and myxoid liposarcomas, contains a gene or genes that are related to cellular proliferation rather than to malignant transformation.
Cancer Center, Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
T A
TA
Walter
S X
SX
Fan
M T
MT
Medchill
C S
CS
Berger
H J
HJ
Decker
A A
AA
Sandberg
D002871:Chromosome Banding; D007446:Chromosome Inversion; D002881:Chromosomes, Human, Pair 12; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D011127:Polyps / Q000235:genetics* / Q000473:pathology; D014594:Uterine Neoplasms / Q000235:genetics* / Q000473:pathology