[Dissolution profiles of powdered inclusion compounds of sulfonamide drugs with beta-cyclodextrin].
The interactions of beta-cyclodextrin (beta-CD) with three sulfonamide drugs were studied. Observations were made on the effects of beta-CD on the solubility and the dissolution rate of these drugs in aqueous solution when comparing two different methods. The solubility of these three drugs was found to increase with the addition of beta-CD. This increase in solubility when using beta-CD was considered to be due to the formation of inclusion compounds. The dissolution rate of drugs increased with beta-CD, and was similar in tendency to the solubility data. These effects on both solubility and dissolution rates were similar regardless of which method was used. The X-ray diffraction pattern of the drug/beta-CD freeze-drying powder showed a clear difference from the physical mixture of intact drugs.
J Y
JY
Chen
W Y
WY
Tsai
D055598:Chemical Phenomena; D002621:Chemistry; D003505:Cyclodextrins / Q000032:analysis*; D003912:Dextrins / Q000032:analysis*; D004339:Drug Compounding / Q000379:methods; D005612:Freeze Drying; D011208:Powders; D012995:Solubility; D013213:Starch / Q000032:analysis*; D013449:Sulfonamides / Q000032:analysis*; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D003912:Dextrins; D011208:Powders; D013449:Sulfonamides; D047392:beta-Cyclodextrins; D013213:Starch; C031215:betadex