Bone marrow aplasia associated with proliferation of large granular lymphocytes and subsequent transformation to acute lymphoblastic leukemia.
Proliferation of large granular lymphocytes may be associated with neutropenia and, less frequently, thrombocytopenia. In this report, we describe a patient with severe aplastic anemia in the setting of a proliferation of cells with natural killer (NK) phenotype. We demonstrated evolution to acute lymphoblastic leukemia by cells of identical phenotype.
Department of Medicine, UCLA School of Medicine 90024-1736.
G J
GJ
Schiller
F
F
Naeim
R E
RE
Champlin
D000741:Anemia, Aplastic / Q000097:blood / Q000276:immunology* / Q000473:pathology; D002455:Cell Division; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000276:immunology* / Q000473:pathology