Embryotoxicity and in vivo cytogenetic changes following maternal exposure to cadmium chloride in mice.
Cadmium is a well-known teratogen in laboratory animals and a widespread environmental pollutant. The frequencies of sister chromatid exchanges (SCEs), nucleolar organizing regions (NORs) and chromosomal aberrations were analysed in maternal bone marrow and fetal liver and/or lung cells of mice, following maternal treatment with cadmium chloride, on gestational days 8 through 10. The embryotoxic effects and morphological changes on day 18 fetuses were also studied. Cadmium chloride is readily transferred across the placenta and significant levels were detected in both the placenta and fetus. No significant changes in the frequencies of SCEs or NORs in maternal and fetal cells were observed following exposure to cadmium chloride. Fetal tissues showed mitotic inhibition at the highest dose levels (8.4 and 11.4 mg/kg, b.w.). Maternal treatment with cadmium chloride increased embryonic resorptions and fetal lethality, as well as reduced placental weight; however, it did not produce significant chromosomal changes except at the highest dose level (11.4 mg/kg).
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.
B N
BN
Nayak
M
M
Ray
T V
TV
Persaud
M
M
Nigli
D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride; D002869:Chromosome Aberrations; D004247:DNA / Q000187:drug effects; D004249:DNA Damage; D005260:Female; D008431:Maternal-Fetal Exchange; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D012854:Sister Chromatid Exchange / Q000187:drug effects
D002104:Cadmium; D004247:DNA; D019256:Cadmium Chloride