[Amphibian bombesin and its analog alytesin].
A convenient route of synthesis of amphibian bombesin and bombesin-like peptide alytesin was found. These tetradecapeptides were obtained by assembling the 1-5 and 6-14 fragments by means of DCC-HONB or mixed anhydrides methods. Structure of the tetradecapeptides was confirmed by high resolution NMR spectroscopy data. The bombesin and alytesin synthesized potently decrease body temperature and stimulate pancreatic juice secretion.
Kuranova
I L
IL
Churkina
S I
SI
Liudmirova
V L
VL
Filonova
E B
EB
Mumulis
F K
FK
D000595:Amino Acid Sequence; D000818:Animals; D001001:Anura; D001839:Bombesin / Q000138:chemical synthesis*; D002852:Chromatography, Ion Exchange; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis*
D010455:Peptides; C000058:alytesin; D001839:Bombesin
Bombezin amfibiĭ i ego analog alitezin.