Prenatal exposure to alcohol: effect on infant growth and morphologic characteristics.
In this prospective study of alcohol and other substance use during pregnancy, a cohort of 650 women was interviewed at each trimester of pregnancy. Data are presented concerning the status of 595 live singleton births. A relationship was demonstrated between prenatal maternal alcohol use and growth and morphologic abnormalities in the offspring. Low birth weight, decreased head circumference and length, and an increased rate of fetal alcohol effects were all found to be significantly correlated with exposure to alcohol during the first 2 months of the first trimester.
Day
N L
NL
School of Medicine, University of Pittsburgh, Pennsylvania.
Jasperse
D
D
Richardson
G
G
Robles
N
N
Sambamoorthi
U
U
Taylor
P
P
Scher
M
M
Stoffer
D
D
Cornelius
M
M
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking; D000437:Alcoholism / Q000150:complications*; D015331:Cohort Studies; D005314:Embryonic and Fetal Development / Q000187:drug effects; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced; D006801:Humans; D007231:Infant, Newborn; D008385:Marijuana Smoking / Q000009:adverse effects; D011247:Pregnancy; D011248:Pregnancy Complications; D011261:Pregnancy Trimester, First; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies; D012907:Smoking / Q000009:adverse effects
D000431:Ethanol