1H image-guided localized 31P MR spectroscopy of human brain: quantitative analysis of 31P MR spectra measured on volunteers and on intracranial tumor patients.
1H image-guided 31P MR spectra of normal human brain and of intracranial tumors have been analyzed quantitatively. Tumor types examined include prolactinoma, lymphoma, and various grade gliomas. The experimental signals were processed by means of a time-domain least-square fitting procedure, which yields the spectral parameters, as well as a prediction of the standard deviations. Significant spectral variations are observed within both populations of normal brain and of intracranial tumor 31P MR spectra. The metabolic ratios derived from the glioma 31P MR spectra and from corresponding uninfiltrated brain tissue do not differ significantly. Significant differences are, however, observed between the metabolic ratios of prolactinoma and uninfiltrated tissue 31P MR spectra. Alkaline pH values are found for the prolactinoma and the high-grade gliomas. Furthermore, spectral differences are observed between the patient's uninfiltrated tissue 31P MR spectra and those of an unmatched population of volunteers. This underscores the necessity for control measurements on the uninfiltrated tissue of the patient and for controls from a matched population of healthy individuals.
Hôpital Erasme, Unité de Résonance Magnétique, Bruxelles, Belgium.
C M
CM
Segebarth
D F
DF
Balériaux
R
R
de Beer
D
D
van Ormondt
A
A
Mariën
P R
PR
Luyten
J A
JA
den Hollander
D000328:Adult; D001921:Brain / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism*; D005583:Fourier Analysis; D005910:Glioma / Q000378:metabolism; D006801:Humans; D008223:Lymphoma / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D010758:Phosphorus; D011336:Probability; D015175:Prolactinoma / Q000378:metabolism
D010758:Phosphorus