Interaction of salicylate and noise results in mortality of rats.
Survival as a function of salicylate dose and the intensity of environmental noise was investigated in 150 adult female pigmented rats. Rats were assigned to groups (n = 6/group) defined by combinations of salicylate levels from 0-(saline) to 300 mg/kg, injected subcutaneously, and noise levels from ambient noise to 98 dB SPL, presented daily for 10-h periods for up to 17 days. Mortality occurred in groups exposed to the higher combinations of salicylate and noise.
University of Massachusetts, Boston.
J F
JF
Brennan
P J
PJ
Jastreboff
D000818:Animals; D001835:Body Weight; D005260:Female; D009026:Mortality; D009622:Noise / Q000009:adverse effects*; D051381:Rats; D012459:Salicylates / Q000097:blood / Q000633:toxicity*
D012459:Salicylates