Chromosomal abnormalities in couples with recurrent abortions.
Out of 126 couples seeking genetic advice for abortions, 95 couples have experienced 2 or more spontaneous abortions. Of these, chromosome banding studies were carried out in one or both partners (92 women and 85 men). Abnormal karyotypes were found in 2 males. Both abnormalities were balanced translocations: 46 XY t(5q+ 11q-) and 45 XY t(13/14). This represents an overall frequency of 1.1% which is comparable to the reported incidence in the literature.
P S
PS
Low
J S
JS
Tay
M A
MA
Tan
T S
TS
Chua
H B
HB
Wong
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D002895:Chromosomes, Human, Pair 5; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D011247:Pregnancy; D014178:Translocation, Genetic