Uncomplicated retrobulbar neuritis and the development of multiple sclerosis.
A retrospective study of 30 patients hospitalized with a diagnosis of uncomplicated retrobulbar neuritis was carried out. The follow-up period was 2-11 years; 57% developed multiple sclerosis. When the initial examination revealed oligoclonal bands in the cerebrospinal fluid, the risk of developing multiple sclerosis increased to 79%. With normal cerebrospinal fluid the risk decreased to only 10%. In the majority of cases, the diagnosis of MS was made during the first 3 years after retrobulbar neuritis.
Department of Ophthalmology, Lillehammer Fylkessykehus, Norway.
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Slettnes
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000209:etiology*; D009902:Optic Neuritis / Q000134:cerebrospinal fluid / Q000150:complications*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors