[Hypothermic effect on mice of a 1-10 kD fraction of the small intestine of the hibernating suslik Citellus undulatus during hypoxia and hypercapnia].
Studies have been made on a possibility of inducing a prolonged hypothermia by injections to albino mice of a fraction with a molecular mass 1-10 KD isolated from the small intestine of hibernating ground squirrels. Specific conditions for the onset of hibernation (hypoxia, hypercapnia, temperature) were simulated. Exposure of mice to hypoxia and hypercapnia for 2 hours in combination with injection of the mentioned fraction extended hypothermic condition in animals up to 24-36 hours as compared to 2-3 hours after sole injection of the fraction. After the injection of 5-OT under the same conditions, the prolonged hypothermia was less stable.
Ignat'ev
D A
DA
Kolaeva
S G
SG
Kramarova
L I
LI
Kravchenko
I I
II
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D006605:Hibernation / Q000187:drug effects; D006935:Hypercapnia / Q000503:physiopathology*; D007035:Hypothermia / Q000139:chemically induced* / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology*; D007421:Intestine, Small; D008297:Male; D051379:Mice; D008970:Molecular Weight; D012589:Sciuridae / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D013997:Time Factors; D014020:Tissue Extracts / Q000494:pharmacology*
D014020:Tissue Extracts; D012701:Serotonin
Gipotermicheskoe vliianie na mysheĭ fraktsii 1-10 kD tonkoĭ kishki giberniruiushchego suslika Citellus undulatus v usloviiakh gipoksii i giperkapnii.