Use of mouse anti-rabies monoclonal antibodies in postexposure treatment of rabies.
Immunization of mice and hamsters with a cocktail of mouse MAbs specific for rabies virus nucleocapsid protein and glycoprotein protected animals not only when challenged with a lethal dose of rabies virus after immunization, but also in post-exposure situations. Hamsters treated with the MAb cocktail 3 h after virus inoculation were completely protected from lethal rabies virus infection, and 80% of the animals survived when the MAb cocktail was given 36 h after virus challenge. The potential usefulness of this MAb cocktail for the postexposure treatment of human rabies is discussed.
Wistar Institute, Philadelphia, Pennsylvania 19104.
C L
CL
Schumacher
B
B
Dietzschold
H C
HC
Ertl
H S
HS
Niu
C E
CE
Rupprecht
H
H
Koprowski
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D000914:Antibodies, Viral / Q000008:administration & dosage / Q000627:therapeutic use*; D000918:Antibody Specificity; D006224:Cricetinae; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D007116:Immunization, Passive / Q000379:methods; D007276:Injections, Intraventricular; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D011818:Rabies / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D011819:Rabies Vaccines