Fatal aplastic anaemia and liver toxicity caused by D-penicillamine treatment of rheumatoid arthritis.
A 65 year old woman with rheumatoid arthritis developed marrow aplasia and jaundice owing to D-penicillamine treatment. Recovery of bone marrow was ineffective, and the patient finally died despite intensive therapeutic measures. The rare coexistence of myelotoxicity and hepatotoxicity is presented and discussed.
Fishel
B
B
Department of Rheumatology, Ichilov Hospital, Tel Aviv Medical Center, Israel.
Tishler
M
M
Caspi
D
D
Yaron
M
M
D000368:Aged; D000741:Anemia, Aplastic / Q000139:chemically induced*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007565:Jaundice / Q000139:chemically induced*; D008099:Liver / Q000187:drug effects; D010396:Penicillamine / Q000009:adverse effects*
D010396:Penicillamine