Clinical correlations of auditory P200 topography and left temporo-central deficits in schizophrenia: a preliminary study.
A number of studies using nontopographic analyses have reported an amplitude decrement of the auditory P200 component in schizophrenics compared to normal controls. Here we report a topographic analysis of the auditory P200 (204-272 ms; peak to baseline) in chronic medicated schizophrenics (N = 11) and normal controls (N = 18) and the correlation between this measure and clinical symptoms in schizophrenia. Exploratory T-statistic mapping (SPM) and "protected" Hotelling's T-squared contrasts of integrated voltages over the entire scalp showed that schizophrenics' P200 component had diminished amplitude in the left temporo-central region. Furthermore, P200 amplitude in the same scalp region during the experimental condition of counting infrequent tones was highly correlated with negative symptoms in the schizophrenic group.
Shenton
M E
ME
Department of Psychiatry, Harvard Medical School, VAMC, Brockton, MA 02401.
Faux
S F
SF
McCarley
R W
RW
Ballinger
R
R
Coleman
M
M
Duffy
F H
FH
D000328:Adult; D001288:Attention / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory; D005625:Frontal Lobe / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000503:physiopathology