[The effect of caffeine on the duration of the mitotic phase cycle in CHO-K1 Chinese hamster cells, irradiated with x-rays].
Alterations in the duration of mitotic cycle phases in X-irradiated Chinese hamster cells CHO K1 after caffeine (CF) treatment are studied. Delays in S- and G2-phases, induced by 1 and 5 Gr of X-irradiation, are partially or completely decreased by 1 mM or 5 mM CF, respectively. When CF is removed from the medium after irradiation, delays in S- and G2-phases are seen again, however long (0-12 hours) CF remains in the medium. The data obtained allow to suggest that since CF results in a radioresistant DNA synthesis, it may also postpone delays in S- and G2-phases, while cells are progressing through the cell cycle.
T V
TV
Kirillova
Iu M
IuM
Rozanov
T B
TB
Seregina
I M
IM
Spivak
D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D005720:Gamma Rays; D007399:Interphase / Q000187:drug effects / Q000528:radiation effects; D008938:Mitosis / Q000187:drug effects*; D013997:Time Factors
D002110:Caffeine
Vliianie kofeina na dlitel'nost' faz mitoticheskogo tsikla u kletok kitaĭskogo khomiachka CHO-K1, obluchennykh rentgenovskimi luchami.