Evaluation of the therapeutic use of radioactive monoclonal antibodies C242 and C215 in transplanted murine tumours.
The therapeutic roles of monoclonal antibodies C242 and C215 labelled with 131I were investigated in transplanted mammary carcinomas. Fragments (10 mg) of mammary tumour from (A x Pc) F1 hybrid mice were implanted subcutaneously in 72 mice of the same strain. Twelve mice were injected with 131I-C242 starting from day 12 following tumour implantation, and eight out of 12 survived for 60 days. By contrast all but one of 36 control mice died within the same time period (P less than 0.0001). Twelve mice were injected with 131I-C215. Seven out of the 12 were alive at 60 days whilst all but 1 of 36 control animals had died (P less than 0.0001). In this study targeted immunotherapy using 131I-labelled antibodies C242 and C215 inhibited tumour growth and prolonged survival. Measurements of tumour area showed a 27-39 percent reduction in the mice receiving the radiolabelled conjugates C242 and C215 (P less than 0.004 and P = 0.028 respectively).
Department of Surgery, Bristol Royal Infirmary.
N A
NA
Habib
B
B
Fermor
M
M
Lucarotti
M
M
Palmer
L
L
Lindholm
C B
CB
Wood
R C
RC
Williamson
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005260:Female; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008325:Mammary Neoplasms, Experimental / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D051379:Mice; D008805:Mice, Inbred A; D009368:Neoplasm Transplantation; D013997:Time Factors
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes