Effects of in vivo perfusion of glutamate dehydrogenase in the guinea pig cochlea on the VIIIth nerve compound action potential.
Glutamate is considered as the best candidate for the neurotransmission between the inner hair cell and the primary efferent neurons in the mammalian cochlea. In order to test its presence in the synapse, a degradative enzyme for glutamate, glutamate dehydrogenase (GDH) was perfused in the cochlea of guinea pigs. The intensity function of the VIIIth nerve compound action potential was recorded as a physiological test. The results show that the GDH induces a decrease in the auditory nerve responsiveness. The threshold elevation observed is dependent upon the enzyme concentration.
INSERM, Laboratoire de Neurobiologie de l'Audition, Montpellier, France.
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D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003051:Cochlea / Q000294:innervation* / Q000502:physiology; D005260:Female; D005969:Glutamate Dehydrogenase / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D000159:Vestibulocochlear Nerve / Q000187:drug effects / Q000502:physiology*
D005969:Glutamate Dehydrogenase