A case of Vogt-Koyanagi-Harada syndrome in a patient affected by Hodgkin's disease.
The Vogt-Koyanagi-Harada (VKH) syndrome, a disease of unknown origin, characterized by inflammation of the uveal tract, retina and meninges, was observed in a patient with Hodgkin's disease (HD) who had been treated with chemotherapy and radiotherapy. Ten years later the patient developed a cluster of neurological symptoms and signs (fever, pain, bilateral hypoacousia, dizziness, uveitis and psychiatric disorder) which were initially interpreted as a relapse of HD. The diagnosis of VKH syndrome was thereafter suspected from the clinical findings, response to therapy and further evolution. During the follow-up (14 months) the patient showed a varying course; hypoacousia remained unaltered while uveitis recurred and only a partial improvement was obtained by immunosuppressive therapy.
Department of Haematology, Niguarda Cà Granda Hospital, Milan, Italy.
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Cipriani
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Landonio
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Canepari
D005260:Female; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D014605:Uveitis / Q000150:complications*; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications*