Stimulation of motility and energy metabolism of spermatozoa from asthenozoospermic patients by 17 beta-estradiol.
Spermatozoa from nine asthenozoospermic patients were incubated for 3 h in Krebs Phosphate Ringer (KRP), supplemented or not with 17 beta-estradiol. 17 beta-estradiol increased the mean velocity and maintained the percentage of motility during the first 2 h of incubation. Oxydative metabolism and intracellular ATP concentrations were enhanced, too, whereas glycolysis remained unchanged.
Laboratoire de Biologie de la Reproduction et du Développement Faculté de Médecine, Lyon, France.
M
M
Idaomar
J F
JF
Guerin
J
J
Lornage
J C
JC
Czyba
D002470:Cell Survival / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D006801:Humans; D007248:Infertility, Male / Q000503:physiopathology; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects* / Q000378:metabolism
D004958:Estradiol