Cimetidine in the treatment of refractory anaphylaxis.
After preoperative intubation and administration of intravenous cefuroxime, a 48-year-old white female developed anaphylactic shock that was refractory to the usual therapeutic measures but was responsive to treatment with intravenous cimetidine. Beta-lactam sensitivity was subsequently confirmed by skin testing. Cimetidine, which antagonizes arterial H2 receptors, may be useful in the treatment of anaphylaxis refractory to the usual resuscitative measures.
Yarbrough
J A
JA
Allergy/Immunology Section, Medical College of Georgia, Augusta.
Moffitt
J E
JE
Brown
D A
DA
Stafford
C T
CT
D000707:Anaphylaxis / Q000139:chemically induced / Q000188:drug therapy*; D002444:Cefuroxime / Q000009:adverse effects; D002927:Cimetidine / Q000627:therapeutic use*; D004342:Drug Hypersensitivity / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005483:Flushing / Q000139:chemically induced; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007431:Intraoperative Complications / Q000188:drug therapy / Q000209:etiology; D008875:Middle Aged; D013610:Tachycardia / Q000139:chemically induced; D014581:Urticaria / Q000139:chemically induced
D002927:Cimetidine; D002444:Cefuroxime