The protective effects of L-ascorbic acid and DL-alpha-tocopherol on cultured rat embryos treated with xanthine/xanthine oxidase.
Abnormalities of the neural suture were observed in cultured rat embryos exposed to oxygen radicals generated by xanthine and xanthine oxidase. The distribution of the severity of these abnormalities was altered by the addition of L-ascorbic acid (AA) or DL-alpha-tocopherol (AT). The antioxidant effect of AA and AT were probably responsible for the protection of the embryos from the damaging effects of oxygen radicals.
BIBRA, Carshalton, Surrey, Great Britain.
A J
AJ
Francis
D
D
Anderson
P C
PC
Jenkinson
D V
DV
Parke
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D005609:Free Radicals; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000494:pharmacology*; D014969:Xanthine Oxidase / Q000633:toxicity*; D014970:Xanthines / Q000633:toxicity*
D005609:Free Radicals; D014970:Xanthines; D014810:Vitamin E; D014969:Xanthine Oxidase; D001205:Ascorbic Acid