The influence of early parathyroidectomy on aluminum-induced rickets in growing uremic rats.
Rats were subjected to a two-stage 5/6 nephrectomy and treated with aluminum for 2 and 4 weeks with a cumulative dose of 4.2 and 8.4 mg of aluminum, respectively. Other animals were parathyroidectomized and loaded with 8.4 mg of aluminum for 4 weeks. Histomorphometry and electron microscopy (tibiae), aluminum tissue (bone, kidney, liver) determination, serum (Ca, Mg, Zn, P, urea, creatinine, alkaline phosphatase, 1,25(OH)2D3, PTH) and urine (creatinine, A1) revealed that: (a) a dose of 8.4 mg aluminum was sufficient to induce rickets within 4 weeks of treatment and was associated with decreased serum calcitriol values and high aluminum accumulation within organs (electron-dense material was found in osteoblasts only); (b) previous parathyroidectomy prevented the occurrence of any aluminum-induced alteration of bone. It was associated with higher calcitriol and phosphorus values than in corresponding non-parathyroidectomized rats and significantly reduced aluminum accumulation within organs. The results was influenced neither by a drop in serum calcium values nor by different degrees of renal failure. We suggest that aluminum-induced rickets in growing uremic rats is prevented or delayed when previous parathyroidectomy has been performed.
Department of Anatomy, Zagreb University School of Medicine, Yugoslavia.
S
S
Vukicević
A
A
Stavljenić
T
T
Boll
M
M
Cervar
C
C
Degenhardt
T
T
Mihaljević
B
B
Krempien
D000535:Aluminum / Q000009:adverse effects* / Q000032:analysis / Q000378:metabolism / Q000652:urine; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism / Q000502:physiology; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000097:blood; D003401:Creatine / Q000097:blood / Q000652:urine; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D010280:Parathyroid Glands / Q000601:surgery*; D010758:Phosphorus / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012279:Rickets / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D014508:Urea / Q000097:blood / Q000652:urine; D014511:Uremia / Q000378:metabolism*
D010758:Phosphorus; D014508:Urea; D000535:Aluminum; D002117:Calcitriol; D003401:Creatine; D002118:Calcium