Integrated complex combinations for the treatment of opportunistic infections in AIDS.
In the present paper the 'serial combinations' (components of the combination offered separately), as used in conventional combination therapy, are compared with the 'integrated complex combination' (offered as fixed combinations). So far, three combinations have been worked out on the basis of this concept (RMP + SMZ + TMP + INH; RMP + SMZ + TMP + PTH; RMP + INH + PTH + DDS). They allow successful treatment of almost all mycobacterial infections and diseases (including tuberculosis and leprosy) and a number of infections caused by gram-negative and gram-positive microorganisms and by Pneumocystis carinii.
Freerksen
E
E
Rosenfeld
M
M
Spannuth
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy; D000900:Anti-Bacterial Agents; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D006801:Humans; D009164:Mycobacterium Infections / Q000188:drug therapy; D009894:Opportunistic Infections / Q000188:drug therapy*
D000900:Anti-Bacterial Agents