[Factors affecting the cholinomimetic activity of alkyltrimethylammonium compounds in experiments on isolated neurons of the mollusk Planorbarius corneus].
It has been shown that the elementary current is independent whereas the duration of channel opening is slightly dependent on the number of methylene groups (from 1 to 9) in the molecule of alkyltrimethylammonium compounds. However, substances with more than 4 methylene groups exhibit lower cholinomimetic activity (i.e. the ability to increase the membrane current) and higher values of Q10 for the reaction with cholinoreceptor. It is suggested that lower activity of these compounds is due to a low rate of formation of a complex with cholinoreceptor because of the higher potential energy barrier.
Skliarov
A I
AI
Lavrent'eva
V V
VV
Danilov
A F
AF
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D066298:In Vitro Techniques; D008974:Mollusca / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010277:Parasympathomimetics / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D010277:Parasympathomimetics; D000644:Quaternary Ammonium Compounds
Faktory, opredeliaiushchie kholinomimeticheskuiu aktivnost' alkiltrimetilammonievykh soedineniĭ v opytakh na izolirovannom neĭrone molliuska Planorbarius corneus.