Relapse rates in moderately severe chronic psoriasis treated with cyclosporin A.
Seventeen patients with chronic psoriasis were given cyclosporin A (CsA) 5 mg/kg per day. Twelve patients cleared within 3 months and their relapse rate, 41% at 6 months, was not significantly different from that previously reported with dithranol or PUVA. This pilot study also suggests that continuing CsA for up to 4 weeks after clinical clearance confers no advantage with regard to relapse. Significant adverse effects on renal function and blood pressure did not occur.
Higgins
E
E
University Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
Munro
C
C
Marks
J
J
Friedmann
P S
PS
Shuster
S
S
D000328:Adult; D002908:Chronic Disease; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012008:Recurrence
D003524:Cyclosporins