Tetracycline in uranyl nitrate intoxication: its action on renal damage and U retention in bone.
In acute intoxication, uranium (U) not only inhibits bone formation but its excretion in urine also causes renal damage. The former effect is ameliorated by tetracycline (TC), probably due to its chelation property, which might also prevent U deposition in bone. Chemical determination of U incorporated in bone and a histological study of the kidneys were performed on animals injected with U and then treated with TC. The results showed that TC was unable to prevent the binding of U to bone while it exacerbated U-induced renal damage.
Guglielmotti
M B
MB
Department of Radiobiology, National Atomic Energy Commission, Buenos Aires, Argentina.
Ubios
A M
AM
Larumbe
J
J
Cabrini
R L
RL
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D007668:Kidney / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013752:Tetracycline / Q000627:therapeutic use*; D014501:Uranium / Q000378:metabolism* / Q000633:toxicity*; D014502:Uranyl Nitrate / Q000633:toxicity*
D014502:Uranyl Nitrate; D014501:Uranium; D013752:Tetracycline