[Effects of gestrinone on serum lipid and lipoprotein levels in women with endometriosis].
Gestrinone (G) was given to 12 females with endometriosis in weekly doses of 5 or 10mg for 4 to 6 months, and the change in serum lipids and lipoproteins was analysed. G decreased total cholesterol by 20% (p less than 0.05), triglycerides by 36% (p less than 0.05), phospholipids by 28% (p less than 0.01) and lipid peroxides by 34% (p less than 0.05), among which reductions in them were statistically significant when compared with the pretreatment levels. Levels of high density lipoproteins (HDL) also fell: HDL-cholesterol by 41% (p less than 0.01), HDL-triglycerides by 49% (p less than 0.05) and HDL-phospholipids by 38% (p less than 0.01) which were significant. Concurrently apolipoproteins (Apo) and lecithin-cholesterol acyltransferase activity (LCAT) decreased: Apo A-I by 31% (p less than 0.01), Apo A-II by 13% (p less than 0.05) and LCAT by 53% (p less than 0.05), which were significant. In contrast, there were few changes in the levels of low density lipoproteins (LDL) and Apo B. There was also little effect on very low density lipoproteins (VLDL) except VLDL-triglycerides which decreased by 52% (p less than 0.05). Meanwhile free fatty acids increased by 61% (p less than 0.05). Therefore, the atherogenic index defined as the ratio of LDL-cholesterol to HDL-cholesterol rose as much as 92% (p less than 0.01) of the initial value in 24 weeks of medication. When these results were examined with respect to the 5 and 10mg administration group, dose-dependent effects were observed, but these were not marked.(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Obstetrics and Gynecology, Kitasato Institute Hospital, Tokyo.
Y
Y
Fukuda
S
S
Tamura
S
S
Hatanaka
D001053:Apolipoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004715:Endometriosis / Q000097:blood* / Q000188:drug therapy; D005260:Female; D005867:Gestrinone / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D009651:Norpregnatrienes / Q000494:pharmacology*; D010743:Phospholipids / Q000097:blood; D014594:Uterine Neoplasms / Q000097:blood* / Q000188:drug therapy
D001053:Apolipoproteins; D008055:Lipids; D008074:Lipoproteins; D009651:Norpregnatrienes; D010743:Phospholipids; D005867:Gestrinone; D002784:Cholesterol