Enhancing activity of anthranilic acid on adjuvant arthritis in rats and antibody formation in mice.
Anthranilic acid (ANA), a metabolite of tryptophan, was examined for its immunopotentiating properties. Administration of ANA (12 mg/kg/day, p.o.) significantly enhanced the development of adjuvant arthritis in rats, although not in a dose-related manner. ANA tended to enhance adjuvant disease moderately suppressed by pretreatment with cyclophosphamide (CY), an immunosuppressive agent. ANA (3-30 mg/kg/day, p.o.) also caused a dose-related enhancement in the antibody formation to sheep erythrocytes (SRBC) in mice.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
M
M
Kunitomo
Y
Y
Tanaka
K
K
Yamada
Y
Y
Yamaguchi
Y
Y
Bandô
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001168:Arthritis / Q000503:physiopathology*; D001169:Arthritis, Experimental / Q000276:immunology / Q000503:physiopathology*; D004912:Erythrocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D012756:Sheep / Q000276:immunology; D013997:Time Factors; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D062367:ortho-Aminobenzoates