[The action of a Chamenerion angustifolium extract in experimental influenza virus infection in mice].
V-2 and V-8, two preparations containing an extract from Chamenerion angustifolium, were tested in vitro and in vivo, for their anti-influenza properties. In vitro, the two preparations induced a significant reduction of the hemagglutinating titers. In vivo, administration of each of the two products, three times before the influenza virus inoculation significantly reduced (27%) the mortality rate and the hemagglutinating titers, and increased the survival mean time (SMT) (about 3.5 times). These effects were more striking when control infection was done seven days after the last administration of the extract: the mortality rate reduces by 50%, the HA titers lowered to zero and the SMT increased by about 5 times.
Institut de recherches chimico-pharmaceutiques, Bucarest, Roumanie.
S
S
Vila
E
E
Prahoveanu
V
V
Eşanu
V
V
Mihăilă
G
G
Pintilie
M
M
Niculescu
N
N
Teoteoi
S
S
Colceru
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000872:Anthocyanins / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000627:therapeutic use; D009980:Influenza A virus / Q000187:drug effects; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use*; D012503:Saponins / Q000627:therapeutic use; D013634:Tannins / Q000627:therapeutic use; D014315:Triterpenes / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D000872:Anthocyanins; D000998:Antiviral Agents; D005419:Flavonoids; D010936:Plant Extracts; D012503:Saponins; D013634:Tannins; D014315:Triterpenes; D001205:Ascorbic Acid
L'action d'un extrait de Chamenerion angustifolium sur l'infection expérimentale à virus de la grippe chez la souris.