Prevention of urate nephropathy in the tumour lysis syndrome.
Patients with acute lymphoblastic leukaemia and a high tumour burden are at risk of developing acute renal failure when given chemotherapy. Rapid cell lysis releases a high urate load which may result in an obstructive urate nephropathy. This complication should be prevented by establishing an alkaline diuresis before initiating steroid or other chemotherapy.
Department of Haematology, Royal Free Hospital, London.
N T
NT
O'Connor
H G
HG
Prentice
A V
AV
Hoffbrand
D000293:Adolescent; D000493:Allopurinol / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003630:Daunorubicin / Q000008:administration & dosage / Q000009:adverse effects; D004231:Diuresis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007674:Kidney Diseases / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D015275:Tumor Lysis Syndrome / Q000150:complications*; D014527:Uric Acid / Q000378:metabolism*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
D014527:Uric Acid; D014750:Vincristine; D000493:Allopurinol; D011239:Prednisolone; D003630:Daunorubicin