[The effect of nerve growth factor, guanethidine and their combined use on nuclease activity in animal tissues].
Activity of ribo- and deoxyribonucleases RNAases I and II, DNAases I and II was studied in brain hemispheres, liver, kidney and heart tissues of one-month-old rats, which were administered daily, beginning from birth either with nerve growth factor 15 micrograms/kg, guanethidine 30 micrograms/kg or with these compounds simultaneously at the doses mentioned above. Activity of the nucleases studied was altered in nervous tissue and in vegeto-dependent tissues after separate treatment with both nerve growth factor and guanethidine, while their simultaneous administration caused slight normalization but not to complete recovery of the patterns studied.
V N
VN
Kaliunov
G P
GP
Petrusenko
K V
KV
Fomichenko
D000818:Animals; D001921:Brain / Q000201:enzymology; D003851:Deoxyribonucleases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004347:Drug Interactions; D006145:Guanethidine / Q000494:pharmacology*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology; D009414:Nerve Growth Factors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012260:Ribonucleases / Q000037:antagonists & inhibitors / Q000378:metabolism*
D009414:Nerve Growth Factors; D003851:Deoxyribonucleases; D012260:Ribonucleases; D006145:Guanethidine
Vliianie faktora rosta nervov, guanetidina i ikh sovmestnogo primeneniia na aktivnost' nukleaz v tkaniakh zhivotnykh.