Use of cefuroxime in preventing postcesarean infection in high-risk patients.
Prophylactic antibiotic therapy is accepted for prevention of postceasarean infection in certain risk groups. Of the antibiotic regimens presented none appears superior. Patients having a cesarean section (CS) more than 6 h after membrane rupture were given three doses of cefuroxime (1.5 g every 8th hour) in a prospective study. This prophylaxis was as efficacious as a 7-day treatment with cefuroxime and cefadroxil. The infection rate was 21% which should be compared to approximately 50% when no prophylaxis was given. Patients with membrane rupture of less than 6 h and having a most urgent CS received the same 24-hour prophylaxis. No postoperative infection was recorded. Women having a CS with an ongoing uterine infection were treated with cefuroxime alone or combined with metronidazole. All but one (91%) had an uneventful recovery.
Department of Obstetrics and Gynecology, Södersjukhuset, Stockholm, Sweden.
P J
PJ
Moberg
K
K
Schedvins
D001424:Bacterial Infections / Q000517:prevention & control*; D002434:Cefadroxil / Q000627:therapeutic use; D002444:Cefuroxime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002585:Cesarean Section; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors
D002511:Cephalosporins; D008795:Metronidazole; D002434:Cefadroxil; D002444:Cefuroxime