Evaluation of neutralizing antibodies to type A, B, E, and F botulinum toxins in sera from human recipients of botulinum pentavalent (ABCDE) toxoid.
Twenty-five serum specimens from personnel immunized with botulinum pentavalent toxoid (ABCDE) had titers of neutralizing antibodies to type A (5.7 to 51.6 IU/ml), type B (0.75 to 18 IU/ml), and type E (0.61 to 10 IU/ml) botulinum toxins. Titers for one type could not be used to predict titers for another type in individuals receiving the toxoid. Cross-neutralizing antibodies to type F botulinum toxin were not detected (less than 0.0125 IU/ml).
Department of Toxinology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701-5011.
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Siegel
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis*; D001681:Biological Assay; D001905:Botulinum Toxins / Q000276:immunology*; D003429:Cross Reactions; D006801:Humans; D051379:Mice; D009500:Neutralization Tests; D014121:Toxoids / Q000276:immunology*
D000907:Antibodies, Bacterial; D014121:Toxoids; D001905:Botulinum Toxins