Muscle pain associated with tubular aggregates and structures resembling cylindrical spirals.
A 42-year-old man complained of muscle pain in the legs and episodes of left-sided limb weakness. Light microscopy of his quadriceps muscle showed abundant subsarcolemmal accumulations with typical histochemical features for tubular aggregates. Electron microscopy showed areas filled with tubular aggregates and vesicular profiles. Scattered within some of the tubular aggregates circular profiles reminiscent of cylindrical spirals were seen. The presence of structures resembling cylindrical spirals within tubular aggregates suggest that they may arise from a component of the sarcoplasmic reticulum. There appears to be an intimate relationship between myalgia and these various types of abnormal membranous profiles; however, the pathophysiology remains to be elucidated.
Department of Neurology, University of Illinois, College of Medicine, Chicago 60612.
M J
MJ
Danon
S
S
Carpenter
Y
Y
Harati
D000328:Adult; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009132:Muscles / Q000648:ultrastructure*; D009135:Muscular Diseases / Q000473:pathology*; D010146:Pain / Q000473:pathology; D012519:Sarcoplasmic Reticulum / Q000648:ultrastructure*