Penetration of cefuroxime into ventricular fluid in cerebrospinal fluid shunt infections.
The penetration of intravenously administered cefuroxime into ventricular fluid was assessed in five pediatric patients with ventriculoperitoneal shunt infections and in one with a ventriculostomy infection. Patients received a total dose of 200 to 230 mg of cefuroxime per kg of body weight per day administered at 8-h intervals. Levels of cefuroxime in ventricular fluid ranged from 1.6 to 22.5 micrograms/ml and were associated with cerebrospinal fluid bactericidal titers ranging from less than 1:2 to 1:16 against infecting staphylococcal isolates. Five infections were cured with cefuroxime monotherapy. On the basis of MIC data, one patient had vancomycin substituted for cefuroxime and the infection was cured.
Myers Black Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
M S
MS
Edwards
C J
CJ
Baker
K M
KM
Butler
E O
EO
Mason
J P
JP
Laurent
W R
WR
Cheek
D000293:Adolescent; D001424:Bacterial Infections / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D002444:Cefuroxime / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D002511:Cephalosporins / Q000134:cerebrospinal fluid*; D002557:Cerebrospinal Fluid Shunts; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D014640:Vancomycin / Q000627:therapeutic use
D002511:Cephalosporins; D014640:Vancomycin; D002444:Cefuroxime