Survival of astroglial cell lineage from adult brain transplant.
We previously described a transplantation model which enables the selective identification of rabbit astroglial cells in sections of mouse brain tissue. In the present paper, we report that cells of the astroglial lineage from an adult transplant are able to survive after implantation into the brain of an immature host. Surviving xenogenic cells are found outside the graft, forming colonies in the host brain parenchyma. However, after 3 months, transplant-derived astrocytes are no longer detected.
Ignacio
V
V
INSERM U 134, Hôpital de la Salpêtrière, Paris, France.
Collins
V P
VP
Suard
I M
IM
Jacque
C M
CM
D000818:Animals; D000911:Antibodies, Monoclonal; D001253:Astrocytes / Q000032:analysis / Q000502:physiology / Q000637:transplantation*; D001921:Brain / Q000166:cytology*; D002465:Cell Movement; D002470:Cell Survival; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000276:immunology; D006085:Graft Survival; D008297:Male; D051379:Mice; D009457:Neuroglia / Q000637:transplantation; D011817:Rabbits; D033581:Stem Cell Transplantation; D013997:Time Factors; D014183:Transplantation, Heterologous
D000911:Antibodies, Monoclonal; D005904:Glial Fibrillary Acidic Protein