Transgenerational effect of orthoaminoasotoluol in mice.
Transplacental effect of orthoaminoasotoluol (OAAT) on the liver was studied in 3 generations of CBA mice. OAAT was administered to mice intragastrically at the 17, 18 and 19th day of pregnancy. A high incidence of liver tumors was observed in males (73.1% compared with 40.6% in control animals) and 34.3% in females compared to 4.6% in control animals which were the F1 descendants of treated mothers. The females of the F2 generation which were not in direct contact with OAAT developed a statistically higher, compared with the control incidence of liver tumors (24%). The liver tumor incidence in males of the F2 (20.6%) and F3 (17.8%) generations was lower than in the control group (40.5%). The liver tumor incidence in the controls was similar to that observed in F3 females (4.05%).
Institute of Carcinogenesis, Cancer Research Center, Moscow, U.S.S.R.
N V
NV
Popova
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D004198:Disease Susceptibility; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000235:genetics; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA / Q000235:genetics; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012737:Sex Factors; D009762:o-Aminoazotoluene / Q000008:administration & dosage / Q000633:toxicity*
D001391:Azo Compounds; D009762:o-Aminoazotoluene