Heparinizable segmented polyurethanes containing poly-amidoamine blocks.
A poly-ether-urea-urethane was synthesized by copolymerization of 4,4'-diphenylmethanediisocyanate (MDI), propanediamine, and poly-oxytetra-methylene glycol (M.W. 1000). Two other corresponding copolymers were also synthesized by adding amino terminated poly-amidoamine macromonomers, purposely synthesized, so as to insert relatively small amounts (6 and 15 weight %) of two types of poly-amidoamine segments in the final product. Of the three copolymers several physicochemical and mechanical properties have been determined, and their heparin adsorption ability, blood compatibility, and cytotoxicity evaluated.
Tanzi
M C
MC
Dept. Chimica Industriale e Ingegneria Chimica G. Natta, Milano, Italy.
Levi
M
M
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004987:Ethers / Q000138:chemical synthesis / Q000494:pharmacology; D006493:Heparin; D007202:Indicators and Reagents; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013718:Tensile Strength; D014508:Urea / Q000138:chemical synthesis* / Q000494:pharmacology
D001672:Biocompatible Materials; D004987:Ethers; D007202:Indicators and Reagents; D011108:Polymers; D011140:Polyurethanes; D014508:Urea; D006493:Heparin