Effects of macromolecular chelators on intestinal cadmium absorption in mice.
Suppression of absorption by macromolecular chelators have been successful with several metals. In this paper a series of immobilized chelators ranging from DTPA to S-containing soft bases have been synthetized and investigated for ability to suppress intestinal uptake of 109Cd2+ in mice. Dextran-0-ethyl-mercaptan, xanthates derived from polysaccharides and polyvinyl alcohol, dithiocarbamates of polyethylene imine and aminoethyl cellulose, and DTPA immobilized on aminopropyl silica were all ineffective. DTPA immobilized on aminoethyl cellulose even enhanced the intestinal uptake. The macromolecular chelators were without extensive effect on organ distribution of absorbed cadmium, except for dithiocarbamate immobilized on polyethylene imine, which enhanced the deposition of cadmium in several organs including the brain. Although the results are discouraging, they indicate that design and synthesis of immobilized vicinal dithio compounds may represent an avenue for development of non-absorbable chelators with high affinity for cadmium.
Department of Environmental Medicine, Odense University, Denmark.
O
O
Andersen
R A
RA
Bulman
J B
JB
Nielsen
D000818:Animals; D002104:Cadmium / Q000493:pharmacokinetics*; D002614:Chelating Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D008670:Metals / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D014018:Tissue Distribution / Q000187:drug effects
D002614:Chelating Agents; D008670:Metals; D002104:Cadmium