Quantal melatonin suppression by exposure to low intensity light in man.
Plasma melatonin concentrations were examined following three relatively low intensities of artificial light. Six normal, healthy control subjects were all exposed to (a) 200 lux, (b) 400 lux and (c) 600 lux for a three hour duration from midnight to 0300 h. Blood was also collected on a control night where light intensity was less than 10 lux throughout. Significant suppression of melatonin was observed following light of 400 lux and 600 lux intensity when compared to the control night (p less than 0.05; Mann-Whitney U-test). 200 lux light did not produce a statistically significant melatonin suppression when compared with control samples. Each light intensity produced its own individual maximal melatonin suppression by one hour of exposure. Increased duration of exposure to the light had no further influence on melatonin plasma concentrations. These data confirm a dose response relationship between light and melatonin suppression, and indicate that there is no reciprocal relationship between the effects of light intensity and the duration of exposure on maximal melatonin suppression in man.
Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
I M
IM
McIntyre
T R
TR
Norman
G D
GD
Burrows
S M
SM
Armstrong
D000328:Adult; D002940:Circadian Rhythm; D006801:Humans; D008027:Light; D008550:Melatonin / Q000097:blood / Q000378:metabolism*; D011863:Radioimmunoassay; D012016:Reference Values
D008550:Melatonin