How phosphocreatine buffers cyclic changes in ATP demand in working muscle.
1. Spatial buffering is hardly necessary for maintaining ATP concentration. 2. Temporal buffering may be essential to defend concentration of products of ATP hydrolysis. ADP would vary 4-fold and AMP would vary 16-fold during a single twitch without buffering. 3. The principal function of the transphosphorylating reaction may be to buffer temporally the concentrations of controlling reactants.
Funk
C
C
Department of Mechanical Engineering, University of Rochester, NY 14627.
Clark
A
A
Connett
R J
RJ
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D002021:Buffers; D004734:Energy Metabolism; D008433:Mathematics; D008962:Models, Theoretical; D009132:Muscles / Q000378:metabolism / Q000502:physiology*; D010725:Phosphocreatine / Q000378:metabolism*; D005082:Physical Exertion
D002021:Buffers; D010725:Phosphocreatine; D000255:Adenosine Triphosphate