[Diminution of the hypoxic effect of conjugate functions in skeletal muscles under the action of gamma-oxybutyric acid].
The resistive, capacitive, and exchange function of vessels in hypoxia (8% O2) was studied on cat shank muscles isolated in relation to hemodynamics. The perfusion pressure reduced by 28%, the pre- and postcapillary resistance by 32 and 35%, the capillary hydrostatic pressure by 12%. The venous flow increased by 0.13 ml/100 g, the capillary filtration coefficient by 58%. Infusion of sodium salt of gamma-oxybutyric acid (GOBA) (10 mg/min) into the region caused lesser changes of parameters while the venous flow increased by 0.63/100 g. Combination of hypoxia and infusion of the agent stabilized precapillary resistance, capillary hydrostatic pressure, and venous flow within ranges close to the initial background, while the capillary filtration coefficient increased by 25%. Changes of perfusion pressure and postcapillary resistance were similar to those recorded under conditions of control hypoxia. The mechanisms of the effect of GOBA sodium salt on conjugate functions of vessels of the skeletal muscles in hypoxia are discussed.
Ibragimov
Iu I
IuI
Tkachenko
B I
BI
D000818:Animals; D002415:Cats; D005260:Female; D000860:Hypoxia / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D009132:Muscles / Q000098:blood supply / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D005680:gamma-Aminobutyric Acid; C009338:succinic semialdehyde
Umen'shenie vliianiia gipoksii na sopriazhennye funktsii sosudov skeletnoĭ muskulatury pri deĭstvii gamma-oksimaslianoĭ kisloty.