Oncogenous osteomalacia: a case study.
A case of oncogenous osteomalacia due to a fibrosarcoma of the maxilla is reported, with a 19 year course before treatment. Metabolic studies of calcium and phosphorus were performed 3 and 19 years after the first symptomology. There was a negative balance for both phosphorus and calcium with low serum levels of 1,25-dihydroxyvitamin D which were corrected by resection of the tumor. Portions of the tumor were cultured and the supernatant did not affect phosphorus transport by a proximal tubule kidney cell line. Other portions were injected into athymic nude mice where they resulted in hypophosphatemia and phosphaturia, thus confirming the endocrine nature of the oncogenous osteomalacia factor.
Nitzan
D W
DW
Department of Oral Surgery, Hadassah University Hospital, Jerusalem, Israel.
Horowitz
A T
AT
Darmon
D
D
Friedlaender
M M
MM
Rubinger
D
D
Stein
P
P
Bab
I
I
Popovtzer
M M
MM
Silver
J
J
D000328:Adult; D000818:Animals; D002118:Calcium / Q000378:metabolism; D005354:Fibrosarcoma / Q000150:complications* / Q000378:metabolism; D006801:Humans; D008297:Male; D008441:Maxillary Neoplasms / Q000150:complications* / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010018:Osteomalacia / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D010758:Phosphorus / Q000378:metabolism; D014407:Tumor Cells, Cultured
D010758:Phosphorus; D002118:Calcium