Pharmacokinetics of cefsulodin in rat cerebrospinal fluid during experimental Pseudomonas aeruginosa meningitis.
Experimental meningitis was induced in rats with Pseudomonas aeruginosa. Bacteria were inoculated in the second ventricle. Twenty hours later cefsulodin penetration was studied in CSF by on-line cannula system which permitted sampling of CSF in the third ventricle. Comparison with healthy animals indicated breakdown of the blood-CSF barrier and high concentrations of cefsulodin were found in CSF.
Faculté de médecine Xavier-Bichart, Laboratoire de Biophysique, Inserm-U13, Paris, France.
A
A
Meulemans
P
P
Vicart
B
B
Pangon
J
J
Mohler
L
L
Bocquet
M
M
Vulpillat
D000818:Animals; D002441:Cefsulodin / Q000134:cerebrospinal fluid*; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid*; D011552:Pseudomonas Infections / Q000134:cerebrospinal fluid*; D051381:Rats; D011919:Rats, Inbred Strains
D002441:Cefsulodin