Effect of venoruton on hypoxic stress-induced neurotoxicity in mice and oxygen free radical generation by human neutrophils.
Venoruton offers a protection against hypoxic stress-induced neurotoxicity (convulsions and death) in mice. It also inhibits free radical generation, since it produces a concentration-dependent (5-160 micrograms/10(6) cells/ml) decrease of chemiluminescence response from human neutrophils. The maximum inhibition was observed at 140 micrograms/10(6) cells/ml. The in vivo protective effect against hypoxic stress-induced neurotoxicity has been correlated to the inhibitory action of venoruton on oxygen free radical generation.
Shukla
V K
VK
Department of Pharmaceutical Sciences, Panjab University, Chandigarh India.
Sethi
A K
AK
Garg
S K
SK
Ganguly
N K
NK
Kulkarni
S K
SK
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005609:Free Radicals; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives* / Q000494:pharmacology; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D008297:Male; D051379:Mice; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D012431:Rutin / Q000031:analogs & derivatives*
D000925:Anticoagulants; D005609:Free Radicals; D006896:Hydroxyethylrutoside; D012431:Rutin; C005865:troxerutin