Using phonation time to estimate vital capacity in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease in which progressive respiratory weakness is usually the proximate cause of death. Since continued assessment of respiratory function is important in predicting progression, phonation time was measured in a group of 41 ALS patients and correlated with measured vital capacity. The findings show that the variance in phonation time accounts for nearly 50% of the variability of vital capacity, and therefore, successive measurements of phonation time are a useful means of estimating the loss of vital capacity.
Department of Otolaryngology/Head and Neck Surgery, University of Washington, Seattle.
A D
AD
Hillel
K
K
Yorkston
R M
RM
Miller
D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011336:Probability; D012044:Regression Analysis; D012119:Respiration; D013060:Speech / Q000502:physiology*; D013997:Time Factors; D014797:Vital Capacity