Nifedipine decreases the mitotic activity of adrenocortical cells in early stage of adrenal regeneration.
The influence of nifedipine, a calcium channel antagonist, on adrenal regeneration was investigated by evaluation of mitotic activity of adrenocortical cells. It was found, that nifedipine given at a daily dose of 10 mg/kg, reduced the proliferation of regenerating adrenal cortex on the fourth day after adrenal enucleation, but the inhibitory effect of nifedipine became insignificant on the eighth day after the operation.
Zieleniewski
J
J
Institute of Endocrinology, Academy of Medicine, Lódź, Poland.
Nowakowska-Jankiewicz
B
B
Zieleniewski
W
W
D000302:Adrenal Cortex / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D000311:Adrenal Glands / Q000502:physiology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration / Q000187:drug effects*
D002121:Calcium Channel Blockers; D009543:Nifedipine