Elevated gastric acid secretion in patients with Barrett's metaplastic epithelium.
Gastric acid secretion in response to a protein meal and to exogenously administered synthetic human gastrin 17-I was measured in patients with Barrett's esophagus, patients with uncomplicated gastroesophageal reflux, and normal age- and sex-matched controls. Acid secretion, both basally and in response to gastrin 17-I, was significantly greater in patients with Barrett's esophagus compared to normal individuals without reflux. Basal gastrin levels and meal-stimulated levels of the hormone were similar among all three groups. Sensitivity to gastrin, expressed as the concentration causing half-maximal acid secretion, was also similar among the study groups. It is speculated that elevated basal acid production in Barrett's esophagus may contribute to the pathogenesis of the disorder.
Department of Surgery, University of Washington, Seattle.
M W
MW
Mulholland
B J
BJ
Reid
D S
DS
Levine
C E
CE
Rubin
D001471:Barrett Esophagus / Q000150:complications / Q000378:metabolism*; D002908:Chronic Disease; D002927:Cimetidine / Q000494:pharmacology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005755:Gastrins / Q000097:blood; D005764:Gastroesophageal Reflux / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D019832:N-Methylscopolamine; D010276:Parasympatholytics / Q000494:pharmacology; D012602:Scopolamine Derivatives / Q000494:pharmacology
D005755:Gastrins; D010276:Parasympatholytics; D012602:Scopolamine Derivatives; C013550:gastrin 17; D002927:Cimetidine; D019832:N-Methylscopolamine