Developing rat cerebellum--II. Effects of abnormal thyroid states and undernutrition on hyaluronic acid.
The early postnatal pattern of hyaluronic acid (HA) deposition in rat cerebellum is affected by thyroid deficiency, thyroxine treatment and undernutrition. The modification of HA ontogenesis apparently reflects the smaller number of cells formed in undernourished rats, or alterations of cell maturation (accelerated in thyroxine-treated and slowed down in thyroid-deficient rats). The developmentally regulated loss of tissue water is also affected in the three conditions; this can be correlated with the roughly simultaneous disappearance of extracellular, but not of total, HA.
Institut de Chimie Biologique de la Faculté de Médecine, Université Louis Pasteur, France.
G
G
Normand
F
F
Vitiello
J
J
Clos
G
G
Gombos
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000254:growth & development* / Q000378:metabolism; D006820:Hyaluronic Acid / Q000378:metabolism*; D007037:Hypothyroidism / Q000378:metabolism*; D009748:Nutrition Disorders / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000494:pharmacology / Q000502:physiology*
D006820:Hyaluronic Acid; D013974:Thyroxine