Effect of supernatants derived from T lymphocyte culture in minimal change nephrotic syndrome on rat kidney capillaries.
The effect on the kidney capillaries of T lymphocyte culture supernatants from patients with minimal change nephrotic syndrome was studied by infusion into the left renal artery of rats. The supernatants of T lymphocyte cultures from nephrotic patients induced significant proteinuria and a reduction of anionic sites in the glomerular basement membrane of the kidneys in the rats. These changes were not produced in rats receiving equivalent supernatants from healthy controls.
Department of Pediatrics, Gunma University School of Medicine, Japan.
K
K
Maruyama
S
S
Tomizawa
N
N
Shimabukuro
T
T
Fukuda
T
T
Johshita
T
T
Kuroume
D000818:Animals; D000838:Anions / Q000378:metabolism; D001485:Basement Membrane / Q000378:metabolism; D001665:Binding Sites; D002196:Capillaries / Q000187:drug effects; D002478:Cells, Cultured; D002648:Child; D003470:Culture Media; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism / Q000648:ultrastructure; D008222:Lymphokines / Q000652:urine; D008297:Male; D009402:Nephrosis, Lipoid / Q000378:metabolism*; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation; D013601:T-Lymphocytes / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D000838:Anions; D003470:Culture Media; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors