Effect of furazolidone and nitrofurazone on brain gamma-amino butyric acid and glutamate concentrations in chickens.
1. The concentrations of gamma-amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, the birds lost about 9% of their bodyweight when on the small dose of FZ or NF and about 18% when on the high doses. 3. Both drugs produced dose-dependent increases in the concentrations of GABA and glutamate which were statistically significant at doses of 25 and 50 mg/kg of NF, and 50 mg/kg of FZ.
Department of Veterinary Medicine, Pharmacology and Toxicology, University of Khartoum, Sudan.
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Ali
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D005664:Furazolidone / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism*; D008297:Male; D009583:Nitrofurazone / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005971:Glutamates; D005680:gamma-Aminobutyric Acid; D005664:Furazolidone; D009583:Nitrofurazone