Cytogenetic and hematological effects in plastics workers exposed to styrene.
For 20 glass-reinforced plastics workers exposed to styrene and 22 unexposed referents, the frequency and size distribution of micronuclei were determined for lymphocytes stimulated with phytohemagglutinin or pokeweed mitogen, and white blood cell counts were made. Furthermore, chromosome aberrations were scored for 11 of the exposed subjects and 15 of the referents. The mean level of styrene in the breathing zone of the workers was 56 mg/m3. Workers exposed to styrene did not show an increase in any of the cytogenetic end points studied when the effect of age and smoking was allowed for in a multiple regression analysis. A significant 30% increase in the number of peripheral monocytes was observed for the exposed workers. No correlations between the cytogenetic and hematological tests on one hand and the length of exposure time on the other could be detected.
Department of Occupational Medicine, University Hospital, Sweden.
L
L
Hagmar
B
B
Högstedt
H
H
Welinder
A
A
Karlsson
F
F
Rassner
D000293:Adolescent; D000328:Adult; D000368:Aged; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects* / Q000648:ultrastructure; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D010969:Plastics; D012997:Solvents / Q000009:adverse effects; D020058:Styrene; D013343:Styrenes / Q000009:adverse effects*
D000395:Air Pollutants, Occupational; D010969:Plastics; D012997:Solvents; D013343:Styrenes; D020058:Styrene