Postprandial gastrin concentrations are higher in female patients with duodenal ulcers.
We compared plasma gastrin concentrations in male and female patients with duodenal ulcers because a group in Denmark reported a difference, but two groups in the Far East did not. Median basal gastrin was 23 pmol/l in males compared with 43 pmol/l in females. Median peak postprandial gastrin was 71 pmol/l in males, compared with 142 pmol/l in females (p less than 0.03). Elevated gastrin may reflect diminished sensitivity of parietal cells to gastrin in females.
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
J
J
Calam
C J
CJ
Springer
J C
JC
Bojarski
M L
ML
Francis-Reme
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004381:Duodenal Ulcer / Q000097:blood* / Q000378:metabolism; D004435:Eating; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012727:Sex Characteristics
D005755:Gastrins