The influence of moderate exercise in diabetic and normal pregnancy on maternal and fetal outcome in the rat.
The effect of treadmill exercise prior to and during pregnancy on maternal and fetal outcome was studied in nondiabetic and streptozotocin-induced diabetic rats. Animals were exercised daily on a motorized treadmill (16.1 m/min, 45 min/d) for three weeks prior to mating and throughout gestation. The catabolic state of diabetes was evidenced by changes in maternal body composition. Overall, fetuses of diabetic dams were smaller, lighter, had less calcified skeletons and had more malformations compared to control fetuses. Exercise in the nondiabetic dams resulted in a retardation of skeletal ossification compared to fetuses from sedentary controls. However, exercise improved fetal outcome in diabetic rats, resulting in increased fetal weight and a lower frequency of malformations compared to fetuses from sedentary diabetic dams.
Department of Internal Medicine, University of California, Davis 95616.
J Y
JY
Uriu-Hare
C L
CL
Keen
E A
EA
Applegate
J S
JS
Stern
D000818:Animals; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D005260:Female; D008098:Litter Size; D010012:Osteogenesis; D010805:Physical Conditioning, Animal; D011247:Pregnancy; D011256:Pregnancy Outcome; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D011270:Pregnancy, Animal / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose