Effects on the urinary level of gamma-carboxyglutamic acid caused by the administration of antibiotics with N-methyl thiotetrazole side chains to patients with infectious diseases.
A comparative study was conducted of the urinary level of gamma-carboxyglutamic acid (gamma-Gla) in patients with infectious diseases to investigate the mechanism of hemorrhagic diathesis occurrence resulting in post-administrative side effects of cephem-group antibiotics. The results showed that the group of administered antibiotics with N-methyl thiotetrazole (NMTT) side chains exhibited decreases in the urinary level of gamma-Gla. Especially, in the aged group of patients (over 65) with non-carcinoma infectious diseases, significant decreases in the urinary level of gamma-Gla were observed. From the above, it is considered that the administration of antibiotics with NMTT side chains has an effect of prohibiting the vitamin K function.
Department of Internal Medicine, Tonan Hospital, Sapporo, Japan.
S
S
Uehara
K
K
Honjo
A
A
Hirayama
K
K
Goto
D015055:1-Carboxyglutamic Acid / Q000652:urine*; D000328:Adult; D000368:Aged; D002511:Cephalosporins / Q000009:adverse effects*; D005260:Female; D006474:Hemorrhagic Disorders / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged
D002511:Cephalosporins; D015055:1-Carboxyglutamic Acid