[The effect of prednisolone on the functional status of phagocytic cells in the peripheral blood of patients with pulmonary sarcoidosis].
An immunological study was carried out of 51 patients with pulmonary sarcoidosis. Two groups of patients were singled out: receiving and not receiving glucocorticoid treatment (prednisolone: 0.3 mg/kg of body weight). It was found that patients with pulmonary sarcoidosis revealed changes of the functional state of neutrophils and monocytes of the peripheral blood manifested in a reduction of their absorptive capacity, number of rosette-forming cells, adhesiveness of neutrophils, increase of oxygen-dependent metabolism, production of lysozyme by neutrophils. Prednisolone treatment effected the state of neutrophils manifested in a reduced acid phosphatase activity; the production of lysozyme increased, the absorptive capacity normalized.
Tyshko
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D006098:Granulocytes / Q000276:immunology; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy / Q000276:immunology*; D009000:Monocytes / Q000276:immunology; D010587:Phagocytosis; D011239:Prednisolone / Q000494:pharmacology*; D012507:Sarcoidosis / Q000188:drug therapy / Q000276:immunology*
D011239:Prednisolone
Deĭstvie prednizolona na funktsionalnoe sostoianie fagotsitiruiushchikh kletok perfericheskoĭ krovi bol'nykh sarkoidozom legkikh.