[Rapid local oscillations of the surface of the human erythrocyte].
The transverse displacements of the human erythrocyte surface with amplitude 300-400 nm in the frequency range 0.2-30 Hz are recorded on the minimal area erythrocyte rim (approximately 0.5 X 0.5 microns). These local oscillations of the surface are diminished at hypoosmotic erythrocyte swelling, on addition of substances which increase the membrane rigidity (0.01% glutaraldehyde, 0.5 mM 4-hydroxymercuribenzoate, cell membrane stain--0.002% Heliogen Blue) and on discocyte--echinocyte transformation due to addition of 1-2 mM 2,4-dinitrophenol. The amplitude of transverse displacements is reduced by 1.7-2 times on erythrocytes of patients with inherent microspherocytosis. These erythrocytes have inherent defects in spectrin. It is suggested that spectrin is important for rapid local oscillations of the human erythrocyte surface.
Krol'
A Iu
AIu
Grinfel'dt
M G
MG
Smil'giavichius
A D
AD
Levin
S V
SV
D004548:Elasticity; D004907:Erythrocyte Deformability; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000502:physiology; D004912:Erythrocytes / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007038:Hypotonic Solutions; D008027:Light; D012542:Scattering, Radiation; D013049:Spectrin / Q000172:deficiency; D013103:Spherocytosis, Hereditary / Q000097:blood; D013499:Surface Properties
D007038:Hypotonic Solutions; D013049:Spectrin
Bystrye lokal'nye kolebaniia poverkhnosti éritrotsita cheloveka.