A new macromolecular antitumor antibiotic, C-1027. III. Antitumor activity.
C-1027, a new macromolecular antitumor antibiotic produced by Streptomyces globisporus C-1027, showed extremely potent cytotoxicity toward cultured cancer cells. Compared in terms of IC50 values, antibiotic C-1027 showed much more potent cytotoxicity than doxorubicin, mitomycin C and neocarzinostatin. Spermatogonial assay, a prescreen for anticancer drugs, was highly sensitive for detection of C-1027. At tolerable doses, C-1027 exhibited marked inhibition on a panel of transplantable tumors in mice, which included leukemia L1210, P388, ascites hepatoma H22, sarcoma 180 and melanoma Harding-Passey.
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing.
Y S
YS
Zhen
X Y
XY
Ming
B
B
Yu
T
T
Otani
H
H
Saito
Y
Y
Yamada
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D053281:Enediynes; D006801:Humans; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D011506:Proteins / Q000494:pharmacology / Q000633:toxicity; D013093:Spermatogonia / Q000187:drug effects; D014410:Tumor Stem Cell Assay
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D053281:Enediynes; D011506:Proteins; C058024:C 1027