[Possibilities of the immunodiagnosis of erythroleukemia].
The authors describe 6 cases of acute leukemia in which erythroid antigens identified by monoclonal antibodies HAE-3 and HAE-9 (against glycophorin A and antigen of nuclear erythroid cells) were expressed on blasts. The morphocytochemical methods were employed to establish different varieties of leukemia according to the FAB-classification: 2-L1, 2-L2, 1-M2, and 1-M. In 4 cases, the existence of the markers of the early stages of differentiation was shown immunologically. Two patients demonstrated the mixed, variant of leukemia (erythroid-T-cellular and erythroid-myeloid). In 5 out of the 6 cases, the patients turned out refractory to chemotherapy. The lethal outcomes were recorded in the first acute period or in the stage of a relapse (one patient) after a very short 2-month remission.
N N
NN
Tupitsyn
M A
MA
Frenkel'
M A
MA
Volkova
A Iu
AIu
Baryshnikov
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007159:Immunologic Tests; D004915:Leukemia, Erythroblastic, Acute / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents
Vozmozhnosti immunodiagnostiki éritroleĭkozov.