Paraproteinaemias and platelet aggregation: role of whole blood aggregometry.
Whole blood and optical platelet aggregation were measured in normals and in patients with paraproteinaemias; extent of aggregation was correlated with paraprotein concentrations in patients and in normals after addition of different doses of paraproteins; threshold aggregating concentrations of several agonists were also determined in whole blood and in PRP from both groups of subjects. The results indicate that patients with macromolecular monoclonal component bear a "hyperaggregable" state which can be probably ascribed also to plasma hyperviscosity and which is better detected with the impedance aggregometer.
Department of Medicine and Experimental Oncology, University of Turin, Molinette Hospital, Italy.
P C
PC
Schinco
A
A
Fusaro
R
R
Marranca
S
S
Battaglio
M
M
Bazzan
A
A
Pannocchia
G
G
Tamponi
A
A
Pileri
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001095:Arachidonic Acids / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000032:analysis; D066298:In Vitro Techniques; D010265:Paraproteinemias / Q000097:blood*; D010266:Paraproteins / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*
D001095:Arachidonic Acids; D007132:Immunoglobulin Isotypes; D010266:Paraproteins; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine