Cardiovascular function and serum catecholamine concentrations after anesthesia and surgery in the dog.
Peripheral vasoconstriction and plasma catecholamine concentrations were studied in 37 dogs after cervical disc fenestration and salivary gland excision, laparotomy for intestinal anastomoses and cystotomy, or laparotomy for repair of diaphragmatic rupture, gastrotomy, and pyloromyotomy. Meperidine (4.4 mg/kg) was administered before extubation of 12 dogs undergoing laparotomy. Heart rate, respiratory frequency, indirect blood pressure, rectal temperature, toe web temperature, and plasma concentrations of epinephrine and norepinephrine were determined before induction of anesthesia, after intubation, after extubation, at sternal recumbency, and at standing. All dogs were hypothermic during surgery. After surgery, peripheral hypothermia (large rectal-toe web temperature gradients) increased from a mean of 4.6 degrees C after intubation to a mean of 10.4 degrees C when the dogs initially stood. Heart and respiratory rates and blood pressures during recovery were similar to those before anesthesia. Mean plasma catecholamine concentrations were neither significantly higher during recovery than before surgery nor were they increased in any surgical group, including the dogs not treated with meperidine. After anesthesia, 15% of the epinephrine and 12% of the norepinephrine samples were more than two standard deviations above the mean of the preanesthetic concentrations of all dogs. The ratio of all dogs with an epinephrine concentration more than two standard deviations above the mean of baseline epinephrine concentrations was greater at sternal recumbency than before anesthesia and the ratio of dogs with an increased epinephrine concentration at sternal recumbency was greater in the laparotomy dogs (9 of 24) than in the cervical surgery dogs (0 of 12).(ABSTRACT TRUNCATED AT 250 WORDS)
Rawlings
C A
CA
Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
Tackett
R L
RL
Bjorling
D E
DE
Arnold
T H
TH
D000758:Anesthesia / Q000662:veterinary*; D000762:Anesthesia Recovery Period; D000818:Animals; D001794:Blood Pressure; D001831:Body Temperature; D002395:Catecholamines / Q000097:blood*; D004285:Dogs / Q000601:surgery*; D004837:Epinephrine / Q000097:blood; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics; D008614:Meperidine / Q000008:administration & dosage; D009638:Norepinephrine / Q000097:blood; D012119:Respiration
D002395:Catecholamines; D008614:Meperidine; D009638:Norepinephrine; D004837:Epinephrine