Naloxone reversal of stress-induced suppression of LH release in the common marmoset.
There is considerable evidence suggesting that endogenous opioid peptides (EOP) might play a role in the defensive response to stressful stimuli. The stress associated with receipt of aggression from a female conspecific and physical restraint for collection of serial blood samples (at 10-min intervals) resulted in a significant (p less than 0.05) suppression of LH secretion in the oestradiol primed ovariectomized marmoset. Administration of the opioid receptor antagonist, Naloxone (1 mg/kg) immediately before and after receipt of aggression completely prevented the stress-induced decrease in LH release. This suggests that EOP may mediate, at least in part, this stress induced decline in LH release in the marmoset.
O'Byrne
K T
KT
M.R.C. Reproductive Biology Unit, Edinburgh.
Lunn
S F
SF
Dixson
A F
AF
D000374:Aggression; D000818:Animals; D002144:Callithrix; D004958:Estradiol / Q000008:administration & dosage; D005260:Female; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D009270:Naloxone / Q000494:pharmacology*; D010052:Ovariectomy; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism*
D009270:Naloxone; D004958:Estradiol; D007986:Luteinizing Hormone