Primary structure of a putative receptor for a ligand of the insulin family.
Nucleotide sequence analysis of human and guinea pig genomic DNA encoding a new member of the insulin receptor (IR) family revealed that the predicted primary structure of this IR-related protein is as similar to the IR and insulin-like growth factor (IGF) I receptor as the IR and IGF-IR are to each other. The conservation of this IR-related sequence among mammals and with the IR and IGF-IR suggests that this IR-related protein is a novel receptor for insulin, IGF-I, IGF-II, or an as yet unidentified peptide hormone or growth factor belonging to the insulin family.
Shier
P
P
Department of Physiology, University of Toronto, Ontario, Canada.
Watt
V M
VM
D000595:Amino Acid Sequence; D000818:Animals; D015139:Blotting, Southern; D003001:Cloning, Molecular; D004247:DNA / Q000302:isolation & purification; D004220:Disulfides; D005796:Genes; D006168:Guinea Pigs; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D011487:Protein Conformation; D011972:Receptor, Insulin / Q000235:genetics / Q000302:isolation & purification*; D012689:Sequence Homology, Nucleic Acid
D004220:Disulfides; D004247:DNA; D011972:Receptor, Insulin; C066542:insulin receptor-related receptor