IL-2 antibody production in lupus mice.
We show here that antibody responses to IL-2 were detected in NZBWF1 and BXSB mice but not in MRL/lpr mice in vivo and in vitro. Lipopolysaccharide (LPS), in the presence or in the absence of T cells, also induced anti-IL-2 antibody production in NZBWF1 and BXSB mouse spleen cells but not in MRL/lpr spleen cells in vitro. Anti-IL-2 antibody production increased progressively with age. Supernatants (SN) obtained from NZBWF1 B cell cultures were able to elicit anti-IL-2 antibody production in LPS-stimulated spleen cells of normal BALB/c mice, whereas SN from NZBWF1 T cells culture had no detectable effect.
Third Department of Internal Medicine, Nara Medical University, Japan.
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Ishizaka
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Tsujii
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D002478:Cells, Cultured; D005260:Female; D007376:Interleukin-2 / Q000172:deficiency / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008213:Lymphocyte Activation; D008212:Lymphocyte Depletion; D008214:Lymphocytes / Q000378:metabolism; D008222:Lymphokines / Q000378:metabolism; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB / Q000276:immunology*; D008815:Mice, Inbred Strains / Q000276:immunology; D008817:Mice, Mutant Strains / Q000276:immunology*
D001323:Autoantibodies; D007376:Interleukin-2; D008222:Lymphokines