Inhibition of growth of human lung adenocarcinoma cell lines by anti-transforming growth factor-alpha monoclonal antibody.
We previously reported that two human lung adenocarcinoma cell lines (A-549 and PC-9) produce human transforming growth factor-alpha (hTGF-alpha) and express its receptors. In the present study an exogenously added monoclonal antibody against recombinant hTGF-alpha inhibited growth of these cell lines in vitro. This result indicated that endogenous hTGF-alpha produced by the cancer cells can function as an autocrine growth factor.
Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan.
K
K
Imanishi
K
K
Yamaguchi
M
M
Kuranami
E
E
Kyo
T
T
Hozumi
K
K
Abe
D000230:Adenocarcinoma / Q000628:therapy*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000918:Antibody Specificity; D002455:Cell Division; D004815:Epidermal Growth Factor / Q000276:immunology; D066246:ErbB Receptors / Q000378:metabolism; D006801:Humans; D007167:Immunotherapy; D066298:In Vitro Techniques; D008175:Lung Neoplasms / Q000628:therapy*; D011869:Radioligand Assay; D011994:Recombinant Proteins / Q000276:immunology; D015291:Transforming Growth Factors / Q000276:immunology* / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D011994:Recombinant Proteins; D004815:Epidermal Growth Factor; D015291:Transforming Growth Factors; D066246:ErbB Receptors