Specific antibody response in porcine respiratory tract secretion following intraperitoneal immunization.
Experiments were conducted to determine whether intraperitoneal (IP) immunization and subsequent intratracheal (IT) challenge were able to augment the specific antibody response in secretions of the porcine respiratory tract. Following IP immunization and two IT challenges within a period of 18 days the specific IgG and IgA antibody response was elevated in respiratory tract secretions and serum. While a portion of the anti-ovalbumin (OVA) IgG in respiratory tract secretions was generated locally, it would appear that the bulk of anti-OVA IgA was derived from serum.
Sheldrake
R F
RF
NSW Agriculture & Fisheries, Veterinary Laboratories, Glenfield, Australia.
D000280:Administration, Inhalation; D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D000941:Antigens / Q000008:administration & dosage; D007114:Immunization; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007274:Injections, Intraperitoneal; D010047:Ovalbumin / Q000276:immunology; D012137:Respiratory System / Q000276:immunology*
D000941:Antigens; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D010047:Ovalbumin