Jumping end-to-end dicentrics in a case of squamous cell carcinoma from a patient with xeroderma pigmentosum.
Cytogenetic studies of a skin squamous cell carcinoma from a xeroderma pigmentosum patient were performed at several passages. They show the existence of recurrent rearrangements: 53% were dicentrics, of which 67% were of the telomere-telomere type. The telomeric region of the long arm of chromosome 12 was the most involved (in 38% of dicentrics), followed by 22p. The origin of this type of jumping rearrangement and its possible role on cell proliferation are discussed.
CNRS URA 620, Institut Curie, Section de Biologie, Paris, France
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Aledo
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Aurias
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Avril
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Dutrillaux
D000293:Adolescent; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000235:genetics*; D002503:Centromere; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D006801:Humans; D007621:Karyotyping; D008297:Male; D012878:Skin Neoplasms / Q000150:complications / Q000235:genetics*; D014983:Xeroderma Pigmentosum / Q000150:complications / Q000235:genetics*