[The interphase death of dividing cells. The effect of oxygen and the pH of the medium on the interphase death of Ehrlich ascites carcinoma cells under the action of ionizing radiation].
Interphase death of in vitro irradiated (200 Gy) Ehrlich ascites tumor cells was studied as a function of oxygenation level and medium pH. The presence of oxygen both during and after irradiation as well as the increase in pH from 7.4 to 8.1 were shown to increase interphase death rate. The pronounced threshold dependence of interphase death of cells upon their concentration may be attributed to hypoxia occurring in a pericellular medium when cells concentration exceeds the threshold.
Iu N
IuN
Korystov
O R
OR
Dobrovinskaia
O V
OV
Degtiareva
L Kh
LKh
Eĭdus
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology* / Q000532:radiotherapy; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003470:Culture Media / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005720:Gamma Rays; D006863:Hydrogen-Ion Concentration; D007399:Interphase / Q000187:drug effects / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010100:Oxygen / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D003470:Culture Media; D010100:Oxygen
Issledovanie interfaznoĭ gibeli deliashchikhsia kletok. Vliianie kisloroda i pH sredy na interfaznuiu gibel' kletok astsitnoĭ kartsinomy Erlikha pri deĭstvii ioniziruiushchego izlucheniia.