Localization of the gene for uridine monophosphate synthase to human chromosome region 3q13 by in situ hybridization.
The bifunctional enzyme uridine monophosphate (UMP) synthase catalyzes the last two steps in de novo pyrimidine biosynthesis. A genetic deficiency in the activity of this enzyme causes the inherited human disease orotic aciduria. We used a human cDNA probe to localize the gene for UMP synthase to human chromosome region 3q13 by the technique of in situ hybridization.
Qumsiyeh
M B
MB
Department of Biochemical and Clinical Pharmacology, St. Jude Children's Research Hospital, Memphis 38101.
Valentine
M B
MB
Suttle
D P
DP
D001345:Autoradiography; D002262:Carboxy-Lyases / Q000235:genetics*; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D004247:DNA / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D008677:Metaphase; D009097:Multienzyme Complexes / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009962:Orotate Phosphoribosyltransferase / Q000235:genetics*; D009964:Orotidine-5'-Phosphate Decarboxylase / Q000235:genetics*; D010430:Pentosyltransferases / Q000235:genetics*; D010957:Plasmids
D005819:Genetic Markers; D009097:Multienzyme Complexes; C027157:uridine 5'-monophosphate synthase; D004247:DNA; D010430:Pentosyltransferases; D009962:Orotate Phosphoribosyltransferase; D002262:Carboxy-Lyases; D009964:Orotidine-5'-Phosphate Decarboxylase