[The effect of the antiarrhythmic, prajmalium bitartrate, on human thrombocyte function].
Studies of the in vitro effects of the antiarrhythmic drug prajmalium bitartrate (PBT, Neo-Gilurytmal) showed inhibitory effects on platelet aggregation and thromboxane production. PBT inhibited the primary and secondary phases of aggregation induced by adrenaline (epinephrine) or adenosine diphosphate (ADP). Platelet aggregation stimulated with collagen, platelet activating factor (PAF), and the thromboxane mimetic 9,11-azo-prostaglandin H2 (U 44064) was inhibited. The secondary phase of aggregation induced by ristocetin and aggregation caused by arachidonic acid (AA) were inhibited in samples from some donors (responders) but not in others (nonresponders). Platelet aggregation by the ionophore calcimycine (A 23187) was not inhibited, but small doses of calcimycine abolished the PBT-induced inhibition of aggregation caused by ADP. Thromboxane production of platelets with collagen of ADP was inhibited by higher concentrations of PBT, whereas AA-induced thromboxane synthesis remained unchanged. The observed antiplatelet activities of PBT are thought to result from calcium and sodium channel blocking properties of the drug.
Medizinische Klinik III, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München.
H
H
Riess
F
F
Bauer
E
E
Hiller
D000404:Ajmaline / Q000031:analogs & derivatives*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors; D011219:Prajmaline / Q000494:pharmacology*; D013931:Thromboxanes / Q000097:blood
D010975:Platelet Aggregation Inhibitors; D013931:Thromboxanes; D000404:Ajmaline; D011219:Prajmaline
Einfluss des Antiarrhythmikums Prajmaliumbitartrate auf die humane Thrombozytenfunktion.