Interstitial hyperthermia of experimental brain tumor using implant heating system.
New experimental system of induction hyperthermia for brain tumor using ferromagnetic implant with low Curie point has been developed. The metal implant is cylindrical needle and made of Fe-Pt alloy with low Curie point suitable for hyperthermia (50-60 degrees C). Induction coil and generator which produce maximum power of 200W and variable frequency of 100-500kHz, yielding magnetic power of 16.7Oe, have been developed. Interstitial hyperthermia was made on rat brain tumor model (T9 gliosarcoma) by this system. Significant effects of single hyperthermia (45 degrees C for 30 minutes) were observed by the extension of life span and morphological changes of the tumor.
Department of Neurosurgery, Nagoya University School of Medicine, Japan.
T
T
Kobayashi
T
T
Tanaka
Y
Y
Kida
M
M
Matsui
T
T
Ikeda
D000818:Animals; D001932:Brain Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D004195:Disease Models, Animal; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods*; D019736:Prostheses and Implants; D051381:Rats