Bromsulphthalein and indocyanine green elimination from plasma, and urinary bromsulphthalein excretion, in normal cats.
The elimination of bromsulphthalein (BSP) and indocyanine green (ICG) from plasma and urinary excretion of BSP were investigated in healthy cats. At 5 mg kg-1, BSP elimination fitted a two-compartment open model, with mean t1/2 beta of 7.1 (SD 2.5) minutes. A tendency for slower elimination of BSP at 10 mg kg-1 suggested saturation of excretory mechanisms, while at 2 mg kg-1 accurate dosing and assay of low BSP concentrations were difficult. Urinary recovery of BSP at 5 mg kg-1 was 0.01 to 0.13 per cent of the total dose. Plasma ICG (0.5 mg kg-1) data fitted a one-compartment open model, with mean t1/2 2.7 (SD 1.0) minutes. In cats, retention tests are more attractive than clearance tests because fewer blood collections are necessary. Proposed reference values are under 3.6 per cent retention of BSP (5 mg kg-1) at 30 minutes and under 17.5 per cent retention of ICG (0.5 mg kg-1) at 15 minutes. At present economic and technical factors favour BSP over ICG.
Department of Veterinary Pathology, University of Sydney, New South Wales, Australia.
D J
DJ
Middleton
A D
AD
Watson
D000818:Animals; D002415:Cats / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005260:Female; D007208:Indocyanine Green / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D013448:Sulfobromophthalein / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D013448:Sulfobromophthalein; D007208:Indocyanine Green