[Aseptic osteonecrosis of the femoral head in cancer patients with neuropathies caused by vincristine and vinblastine].
Aseptic osteonecrosis has been described in many and dissimilar pathologic conditions--most frequently as the aftermath of fractures or dislocations; in falciform anemia, obesity, alcoholism; in diseases requiring constant and heavy corticosteroid therapy, and also following renal transplantation. Many of these pathologies, especially alcoholism, diabetes, uremia, and collagen vascular diseases, have a common denominator: peripheral neuropathy, which is believed to be a pathogenetic factor supporting osteonecrosis. The authors analyze 3 cases of aseptic osteonecrosis of the femoral head in cancer patients treated with vincristine and/or vinblastine. Since in these subjects severe and persistent neuropathy preceded the onset of osteonecrosis, a possible relationship is postulated between the vincristine/vinblastine treatment and the onset of femoral head osteonecrosis, through the pathogenetic mechanism of peripheral neuropathy.
Meneghello
A
A
Complesso Clinico Ospedaliero, Padova.
Presacco
D
D
Di Maggio
C
C
D000328:Adult; D001177:Arthropathy, Neurogenic / Q000139:chemically induced* / Q000150:complications; D001859:Bone Neoplasms / Q000188:drug therapy; D005260:Female; D005271:Femur Head Necrosis / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy; D008875:Middle Aged; D010017:Osteoma, Osteoid / Q000188:drug therapy; D011859:Radiography; D013724:Teratoma / Q000188:drug therapy; D014747:Vinblastine / Q000009:adverse effects*; D014750:Vincristine / Q000009:adverse effects*
D014750:Vincristine; D014747:Vinblastine
Osteonecrosi asettica della testa femorale in pazienti neoplastici con neuropatia da vincristina e vinblastina.