Degradation of 5-chloro-2-hydroxynicotinic acid by Mycobacterium sp. BA.
Bacteria with the ability to use 5-chloro-2-hydroxynicotinic acid as sole source of carbon and energy have been isolated from enrichment cultures with 2-hydroxynicotinic acid and 5-chloro-2-hydroxynicotinic acid. According to their morphological and physiological properties, these bacteria have been classified as Mycobacterium sp. The first metabolite in the degradation pathway is 5-chloro-2,6-dihydroxynicotinic acid. 2-Hydroxynicotinic acid had an inductive effect on the degrading enzymes. Chloride was released from 5-chloro-2-hydroxynicotinic acid, chloromaleic acid and chlorofumaric acid. A degradation pathway is proposed.
Tibbles
P E
PE
Institut für Mikrobiologie, Universität Hohenheim.
Müller
R
R
Lingens
F
F
D005650:Fumarates / Q000378:metabolism; D008298:Maleates / Q000378:metabolism; D009161:Mycobacterium / Q000302:isolation & purification* / Q000378:metabolism; D009539:Nicotinic Acids / Q000378:metabolism*
D005650:Fumarates; D008298:Maleates; D009539:Nicotinic Acids; C061111:5-chloro-2-hydroxynicotinic acid; C061114:2-chloromaleic acid; C061112:2-chlorofumaric acid