Synthesis, antiinflammatory and antiarthritic properties of a new tiopronine gold derivative.
The synthesis of triethylphosphine gold complex with the alpha-mercaptopropionylglycine ethyl ester (compound 3) is reported. The new compound shows an antiinflammatory and antiarthritic activity superior to auranofin.
G
G
Coppi
F
F
Borella
M T
MT
Gatti
A
A
Comini
L
L
Dall'Asta
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D006046:Gold / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D008625:Tiopronin / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006046:Gold; D008625:Tiopronin