A fulminant case of Guillain-Barré syndrome: topographic and fibre size related analysis of demyelinating changes.
In a necropsy case of early fulminant Guillain-Barré syndrome, demyelinating changes were observed throughout the peripheral nervous system, most conspicuous in the spinal nerve roots. The central/peripheral nervous system transition regions and most proximal zones of the roots escaped damage. In some root areas there were widespread early changes in myelin sheaths in the absence of significant infiltrates of inflammatory cells. In the fibre size analytical study, small myelinated fibres were preferentially involved.
Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan.
T
T
Kanda
H
H
Hayashi
H
H
Tanabe
T
T
Tsubaki
M
M
Oda
D003391:Cranial Nerves / Q000473:pathology; D003711:Demyelinating Diseases / Q000473:pathology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009186:Myelin Sheath / Q000473:pathology; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D010525:Peripheral Nerves / Q000473:pathology; D011129:Polyradiculoneuropathy / Q000473:pathology*; D011782:Quadriplegia / Q000473:pathology; D013126:Spinal Nerve Roots / Q000473:pathology; D014630:Vagus Nerve / Q000473:pathology