The alpha 2 chain of type 1 collagen does not map to mouse chromosome 16 but maps close to the Met proto-oncogene on mouse chromosome 6.
The gene locus for the alpha 2 chain of type 1 collagen (Cola-2) was previously assigned to chromosome 16. Here we demonstrate, utilising both somatic cell hybrid analysis and genetic linkage analysis, in an interspecific Mus domesticus x Mus spretus cross that Cola-2 fails to cosegregate with mouse chromosome 16, but is linked to the Met proto-oncogene on chromosome 6.
Department of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, London, UK.
N G
NG
Irving
J A
JA
Hardy
N
N
Bahary
J M
JM
Friedman
S D
SD
Brown
D000818:Animals; D002874:Chromosome Mapping; D003094:Collagen / Q000235:genetics*; D006224:Cricetinae; D003412:Cricetulus; D003433:Crosses, Genetic; D005260:Female; D006822:Hybrid Cells; D008297:Male; D051379:Mice; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes
D003094:Collagen