Solubility of I-653, sevoflurane, isoflurane, and halothane in human tissues.
Tissue/blood partition coefficients of anesthetics are important indicators of the rate of tissue wash-in and wash-out, and wash-in and wash-out are determinants of the rates of induction of and recovery from anesthesia. In the present study of human tissues, we found that the tissue/blood partition coefficients (for brain, heart, liver, kidney, muscle, and fat) for the new anesthetic I-653 were smaller than those for isoflurane, sevoflurane, and halothane (anesthetics listed in order of increasing tissue/blood partition coefficients). For example, the respective brain/blood partition coefficients were 1.29 +/- 0.05 (mean +/- SD); 1.57 +/- 0.10; 1.70 +/- 0.09; and 1.94 +/- 0.17. This indicates that induction of and recovery from anesthesia with I-653 should be more rapid than with the other agents. The finding of a lower tissue/blood partition coefficient for I-653 parallels the previous finding of a lower blood/gas partition coefficient.
Yasuda
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Department of Anesthesia, University of California, San Francisco 94143-0464.
Targ
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AG
Eger
E I
EI
D000368:Aged; D000375:Aging / Q000378:metabolism; D000777:Anesthetics / Q000378:metabolism*; D002849:Chromatography, Gas; D000077335:Desflurane; D004987:Ethers / Q000378:metabolism*; D006221:Halothane / Q000378:metabolism*; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000378:metabolism*; D008738:Methyl Ethers; D008875:Middle Aged; D000077149:Sevoflurane; D012995:Solubility; D014018:Tissue Distribution
D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane; D006221:Halothane