Isolation of drug residues from tissues by solid phase dispersion.
A new method based on solid phase dispersion of tissue for the subsequent isolation of drugs is reported. By blending tissues with a polymeric phase bound to a solid support one obtains a semi-dry material which can be used as a column packing material from which one can isolate drugs in a stepwise fashion based on the solubility characteristics of the drugs in this matrix. The applicability of this approach for multidrug residue extraction from a single sample is demonstrated for compounds representing the organophosphate, benzimidazole anthelmintic and beta-lactam antibiotic drug classes.
Department of Physiology, Pharmacology and Toxicology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803.
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification; D002417:Cattle; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000302:isolation & purification*; D007769:Lactams; D009132:Muscles / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D007769:Lactams