Effects of anticholinergic drugs on regional brain neurotensin concentrations.
Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.
Levant
B
B
Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.
Bissette
G
G
Nemeroff
C B
CB
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects*; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009496:Neurotensin / Q000378:metabolism*; D010276:Parasympatholytics / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012601:Scopolamine / Q000494:pharmacology
D010276:Parasympatholytics; D009496:Neurotensin; D001285:Atropine; D012601:Scopolamine; D006220:Haloperidol