[Systematic study of various tumoral markers in prevalent bone metastasis].
In the presence of prevalent bone metastases, the precise histo-pathological diagnosis of the primary tumor is often difficult. The authors study the diagnostic value of systematic serum assay of a series of tumoral tracers (ACE, AFP, PAP and PSA, SCC, CA 19:9, CA 15:3, CA 125) which until now were used in evolutive and therapeutic monitoring. 34 patients were selected for this preliminary retrospective study (including 20 with a demonstrated histopathological diagnosis). 70 p. cent of prevalent bone metastases express a target tracer corresponding to the initial location. In some cases, an elevated tracer, because of its specificity, may bring about a diagnostic or therapeutic decision (always according to the context). No conclusion may currently be drawn in case of discordance between the anatomo-clinical context and the "profile" of the markers (1 case in our series).
Service de Rhumatologie, CHU de Nice et du Centre Antoine Lacassagne, Nice.
L
L
Euller-Ziegler
D
D
Pons-Anicet
B P
BP
Krebs
J F
JF
Leyge
F
F
Nectoux
A
A
Thyss
G
G
Ziegler
D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000097:blood / Q000556:secondary*; D006801:Humans; D012189:Retrospective Studies
D014408:Biomarkers, Tumor
Apport de l'étude systématique de différents marqueurs tumoraux dans les métastases osseuses prévalentes.