MRI detection of myocardial perfusion changes by gadolinium-DTPA infusion during dipyridamole hyperemia.
To detect abnormal regional myocardial coronary flow reserve, serial spin-echo MR tomograms of four control dogs and six with a partial balloon occlusion of the left anterior descending (LAD) coronary artery were acquired before and after dipyridamole infusion and during the paramagnetic effect of a bolus plus infusion of gadolinium-DTPA. Microsphere myocardial blood flow was measured for correlation with serial regional changes in MR signal intensity. Significant difference in gadolinium-enhanced MR signal intensity existed between the hypoperfused LAD and the hyperemic left circumflex perfusion beds (46 +/- 22% vs 78 +/- 29% above baseline, respectively; P less than 0.05). The percentage changes in gadolinium-enhanced MR signal and microsphere myocardial blood flow were significantly correlated (r2 = 0.93).
Miller
D D
DD
Department of Medicine, Massachusetts General Hospital, Boston 02114.
Holmvang
G
G
Gill
J B
JB
Dragotakes
D
D
Kantor
H L
HL
Okada
R D
RD
Brady
T J
TJ
D000818:Animals; D003287:Contrast Media; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000473:pathology / Q000503:physiopathology*; D004176:Dipyridamole / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004285:Dogs; D005682:Gadolinium; D019786:Gadolinium DTPA; D006940:Hyperemia / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds; D004369:Pentetic Acid; D014664:Vasodilation / Q000187:drug effects
D003287:Contrast Media; D009942:Organometallic Compounds; D004176:Dipyridamole; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA