[Portal vein infusion therapy of the prevention of liver metastasis from colorectal carcinomas].
For patients who underwent curative resections for primary colorectal carcinomas, locally recurrent tumors and metastatic liver tumors, we applied portal vein infusion therapy to prevent further metastases to the liver. Following radical resection of the tumor, dissecting the umbilical vein from the falciform ligament made it possible to recanalize and insert a 18 G catheter into the portal vein. Intraportal chemotherapy (5-FU 750 mg/day) was carried out for the first 7 postoperative days. There were 17 patients who received this therapy, 10 with curative resection for the primary cancers, 1 with curative resection for the locally recurrent tumor and 7 with the curative resection for the metastatic liver tumors. The follow-up period is rather short (17 months) but no patients have had the liver metastases. So we suggest that this adjuvant liver infusion may reduce the liver metastases without any mortality or morbidity.
Second Dept. of Surgery, Tokyo Medical and Dental University.
Y
Y
Okubo
H
H
Maruyama
M
M
Imajo
T
T
Iwama
K
K
Yaegashi
Y
Y
Mishima
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000188:drug therapy / Q000517:prevention & control* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D014018:Tissue Distribution
D005472:Fluorouracil