Effects of idebenone on lipid peroxidation and hemolysis in erythrocytes of stroke-prone spontaneously hypertensive rats.
Stroke-prone spontaneously hypertensive rats (SHRSP) were kept on a 1% NaCl solution as drinking water to shorten the onset-time of a stroke. The level of lipoperoxide (LPO) in the erythrocytes of SHRSP loaded with salt for 22 days was significantly higher than that of the controls. Idebenone treatment (30 mg/kg per day, p.o.) markedly decreased the LPO to the level of the controls. Hemolysis in SHRSP was accelerated by the salt-loading. Idebenone significantly inhibited the hemolysis in a dose-dependent manner. These results suggest that idebenone inhibits lipid peroxidation in erythrocytes and stabilizes the erythrocyte membrane.
Central Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan.
M
M
Suno
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M
Shibota
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A
Nagaoka
D000818:Animals; D016227:Benzoquinones; D002561:Cerebrovascular Disorders / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D006461:Hemolysis / Q000187:drug effects*; D006973:Hypertension / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D011809:Quinones / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D014451:Ubiquinone / Q000031:analogs & derivatives
D016227:Benzoquinones; D011809:Quinones; D014451:Ubiquinone; C036619:idebenone