The developmental toxicity of an isolate from the plant Solanum dimidiatum (potato-weed) in Syrian golden hamsters.
The developmental toxicity of an ethanol extract from Solanum dimidiatum was investigated in date-bred Syrian golden hamsters. Neural tube defects were seen in three Syrian golden hamster fetuses, from one litter out of 12, at a maternal dose of 1.52 mg of plant isolate per g of body weight. Other malformations observed were syndactyly in a single fetus, from one litter out of ten, in the 0.45 mg/g dose group and gastroschisis in a single fetus, from one litter out of nine, in the 1.01 mg/g dose group. These findings suggest minimal developmental toxicity for this plant isolate.
Casteel
S W
SW
Department of Veterinary Physiology, Texas A&M University, College Station 77843.
Bailey
E M
EM
Camp
B J
BJ
Bridges
C H
CH
Hejtmancik
E
E
Ueckert
D N
DN
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006224:Cricetinae; D010064:Embryo Implantation; D005260:Female; D005327:Fetal Resorption; D005333:Fetus / Q000187:drug effects; D005865:Gestational Age; D008647:Mesocricetus; D010936:Plant Extracts / Q000633:toxicity*; D011247:Pregnancy; D011198:Solanum tuberosum / Q000032:analysis*; D013723:Teratogens
D010936:Plant Extracts; D013723:Teratogens