The effect of endotoxin on nociception in mice.
The possible antinociceptive activity of endotoxin was studied in mice. The antinociceptive properties of endotoxin (0.0003, 0.003, 0.03, 0.3 and 3 mg/kg, i.p.) were evaluated using the phenylbenzoquinone-induced writhing test. The antinociceptive activity of endotoxin was more potent than that of aminopyrine and morphine.
Ishikawa
M
M
Department of Toxicology and Pharmacology, Cancer Research Institute, Tohoku College of Pharmacy, Sendai, Japan.
Sugawara
S
S
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D000983:Antipyrine / Q000494:pharmacology; D016227:Benzoquinones; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D011809:Quinones; D013997:Time Factors
D016227:Benzoquinones; D004731:Endotoxins; D011809:Quinones; C029322:phenylbenzoquinone; D009020:Morphine; D000983:Antipyrine