The effects of Oradexone and Ambroxol pretreatment of the oxidative sensitivity of the red blood cells in preterm infants.
The antioxidant enzyme activities and lipid peroxidation in the red blood cells of cord blood were investigated and compared at different gestation times in preterm and full-term neonates, with and without pretreatment of the pregnant mothers with Oradexone (Dexamethasone) or Ambroxol. Administration of the two drugs not only stimulated the lung surfactant system, but also exerted favourable effects on the antioxidant enzyme activities while the lipid peroxidation was decreased.
Novák
Z
Z
County and Municipal Children's Hospital, Szeged, Hungary.
Varga
S I
SI
Kovács
L
L
Pál
A
A
Pataki
L
L
Matkovics
B
B
D000551:Ambroxol / Q000494:pharmacology*; D000975:Antioxidants / Q000097:blood; D001964:Bromhexine / Q000031:analogs & derivatives*; D003907:Dexamethasone / Q000494:pharmacology*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005312:Fetal Blood / Q000201:enzymology; D006801:Humans; D007231:Infant, Newborn / Q000097:blood; D007234:Infant, Premature / Q000097:blood*; D015227:Lipid Peroxidation / Q000187:drug effects; D008168:Lung / Q000196:embryology; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D000975:Antioxidants; D000551:Ambroxol; D003907:Dexamethasone; D001964:Bromhexine