[Oxygen radical production of alveolar inflammatory cells in sarcoidosis and idiopathic lung fibrosis].
Interstitial lung diseases are characterised by chronic inflammatory processes in the lower respiratory tract, parenchymal cell injury and progressive fibrosis of the alveolar structure. Oxygen radicals are claimed to be a major cause of the tissue damage in the lung. We evaluated the spontaneous and stimulated oxygen radical release of bronchoalveolar lavage (BAL) cells in 35 patients with sarcoidosis and 17 patients with IPF. In comparison with the control in both diseases the spontaneous as well as the stimulated oxygen radical release of the BAL cells is markedly increased. In IPF alveolar macrophages produce the buk part of radicals (84%). Due to their low percentage and in spite of a higher activity on a per cell basis the contribution of neutrophils to the total radical burden is only marginal. In sarcoidosis there is a positive correlation between the oxygen radical release of AM and the CD4/CD8 ratio of BAL lymphocytes. Our results demonstrate that the clinical activity of sarcoidosis and IPF is reflected by the oxygen radical release of BAL cells.
Strausz
J
J
Müller-Quernheim
J
J
Steppling
H
H
Borkowski
A
A
Ferlinz
R
R
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D005260:Female; D005609:Free Radicals; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D010101:Oxygen Consumption; D011658:Pulmonary Fibrosis / Q000276:immunology*; D012507:Sarcoidosis / Q000276:immunology*
D005609:Free Radicals
Sauerstoffradikalproduktion alveolärer Entzündungszellen bei Sarkoidose und bei idiopathischer Lungenfibrose.