Synthesis and pharmacological evaluation of triazolo derivatives of 8-amino-10,11-dihydro-dibenzo[b,e]1,4-thiazepine-11-one.
In the present communication, the syntheses, characterization and pharmacological evaluation of 8-amino-(1,2,4)-triazolo[4,3-d][b,e]1,4-dibenzothiazepine (4) and its various substituted analogs (6-9) are reported.
Joshi
J
J
Chemical Laboratory, University of Rajasthan, Jaipur, India.
Joshi
B C
BC
Barar
F S
FS
D000661:Amphetamine / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000633:toxicity; D005106:Exploratory Behavior / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D013841:Thiazepines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000927:Anticonvulsants; D002491:Central Nervous System Agents; D013841:Thiazepines; C060776:8-amino-10,11-dihydrodibenzo(b,e)1,4-thiazepin-11-one; D000661:Amphetamine; D010424:Pentobarbital