Functional activity patterns in the forebrain of swimming rats: a 5 min 2-deoxyglucose study.
Effects of 5 min of swimming on functional activity patterns in the rat forebrain were examined by high resolution autoradiographic assessment of [14C]2-deoxyglucose ([14C]2-DG) uptake. In autoradiograms made from swimming rats, the isocortex displayed a columnar pattern in which columns of high optical density, oriented perpendicularly to the cortical surface, were separated by columns of low optical density of similar orientation. Increased [14C]2-DG uptake in swimming rats compared to resting rats was also apparent in the lateral septal nucleus, globus pallidus, and endopiriform nucleus. The results demonstrate that 2-DG can be used in short survival uptake experiments to gain insight into neuroanatomical patterns of functional activity.
Department of Cell Biology and Anatomy, School of Medicine, University of North Carolina, Chapel Hill 27599.
G E
GE
Duncan
W E
WE
Stumpf
G R
GR
Breese
K E
KE
Mitra
D000818:Animals; D001345:Autoradiography; D003837:Deoxy Sugars / Q000493:pharmacokinetics*; D003847:Deoxyglucose / Q000493:pharmacokinetics*; D004734:Energy Metabolism; D005625:Frontal Lobe / Q000378:metabolism* / Q000502:physiology; D008297:Male; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming
D003837:Deoxy Sugars; D003847:Deoxyglucose