Carcinogenic tryptophan pyrolysis products in airborne particles and rain water.
This is the first report that carcinogenic tryptophan pyrolysis products are present in airborne particles and rain water. The airborne particles were collected from August 1988 through October 1988 at 4 locations in Japan. The amounts of 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) in the air were 0.23 +/- 0.17 pg/m3 air (mean +/- SD, n = 18) and 0.16 +/- 0.15 pg/m3 air (n = 18), respectively. Moreover, these carcinogens were detected in rain water. These results indicate that Trp-P-1 and Trp-P-2 are ubiquitous environmental components.
Department of Hygiene and Preventive Medicine, Faculty of Medicine, University of Tokyo, Japan.
S
S
Manabe
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E
Uchino
O
O
Wada
D000393:Air Pollutants / Q000032:analysis*; D002243:Carbolines / Q000032:analysis*; D002274:Carcinogens, Environmental / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D013058:Mass Spectrometry; D011891:Rain; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D014887:Weather
D000393:Air Pollutants; D002243:Carbolines; D002274:Carcinogens, Environmental; C019133:3-amino-1-methyl-5H-pyrido(4,3-b)indole; C019132:3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole