Low calcium-induced epileptiform activity in hippocampal slices from infant rats.
Ca2+-free solutions evoke spontaneous epileptiform activity in area CA1 of hippocampal slices from adult and young rats at the age of 7/8, 14/15 and 23/24 days. Studies with combined Ca2+-selective and K+-selective microelectrodes showed that this epileptiform activity commenced at higher Ca2+ levels in young than in adult animals. Unlike in disinhibition seizures, [K+]o did not rise to abnormally high levels. We further found that Ca2+ washout curves from young animals were much faster than those from adult slices, suggesting that the extracellular space is wider in young animals than in adult ones.
Institute of Neurophysiology, University of Cologne, Cologne, F.R.G.
D
D
Albrecht
U
U
Heinemann
D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000502:physiology*; D004827:Epilepsy / Q000503:physiopathology*; D006624:Hippocampus / Q000254:growth & development / Q000503:physiopathology*; D066298:In Vitro Techniques; D051381:Rats
D002118:Calcium