Isolation of a natural cytotoxic IgM "antibody" in human serum sensitizing L cells to complement.
An IgM fraction of human serum was isolated and purified. A portion of this fraction firmly attaches to L cells' surfaces, which sensitizes these cells to the lytic action of low concentrations of serum C. It contains the natural cytotoxic "antibody" to L cells.
Bolande
R P
RP
Department of Pathology, East Carolina University, School of Medicine, Greenville, North Carolina 27855.
Mayer
D C
DC
D000818:Animals; D000937:Antigen-Antibody Reactions; D003167:Complement Activation; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology* / Q000302:isolation & purification; D007739:L Cells / Q000276:immunology*; D051379:Mice; D011247:Pregnancy
D007075:Immunoglobulin M