Diabetes enhances vasoreactivity to calcium entry blockers.
Equipotent concentrations of diltiazem and verapamil relaxed coronary resistance vessels in isovolumically-perfused rat hearts. In diabetic hearts, the vasodilator response to diltiazem, and to a lesser extent verapamil, was significantly augmented. The addition of both calcium entry blockers also produced greater relaxation in precontracted isolated thoracic aorta of diabetic animals suggesting that diabetes increases the sensitivity of calcium entry blockers in two separate vessel types.
Pieper
G M
GM
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226.
Gross
G J
GJ
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004110:Diltiazem / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D014655:Vascular Resistance / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil; D004110:Diltiazem