Matrix protein of cell-associated subacute sclerosing panencephalitis viruses.
The nucleotide sequence has been determined for the matrix (M) protein gene of three strains, Niigata-1, ZH and Biken, of cell-associated subacute sclerosing panencephalitis (SSPE) virus. The M proteins of the Niigata-1 and ZH strains were found to terminate prematurely as a result of nonsense mutations at nucleotide positions 68 and 96 respectively. On the other hand it was predicted that the Biken strain would express M protein with 22 amino acid differences and eight additional amino acids at its C terminus in comparison to the M protein of the Edmonston strain of measles virus. Radiolabelling of cells carrying the Biken strain showed the production of an M protein with considerably altered immunoreactivity and a marked reduction in intracellular stability. Either premature termination or rapid degradation of the M protein may underlie the defectiveness of these three strains of SSPE virus.
Department of Measles Virus, National Institute of Health Gakuen, Tokyo, Japan.
M
M
Enami
T A
TA
Sato
A
A
Sugiura
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002522:Chlorocebus aethiops; D005796:Genes; D005814:Genes, Viral; D008969:Molecular Sequence Data; D011233:Precipitin Tests; D013190:SSPE Virus / Q000235:genetics*; D014709:Vero Cells; D014763:Viral Matrix Proteins / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification
D014763:Viral Matrix Proteins