[Measurement for instantaneous acceleration of ventricular pressure and its significant].
The indices of the first and second derivatives of the left ventricular pressure were compared in terms of their inotropic sensitivity and preload, afterload and heart rate dependence in 14 rabbits. In comparison with (dp/dt)max, (d2p/dt2)max is more sensitive to inotropic stimulation. Both indices are increased with increasing preload, afterload and heart rate (HR), but the difference in their dependences on load and HR is not statistically significant. The results suggest that (d2p/dt2)max is a better index of ventricular performance than (dp/dt)max.
Guo
Z M
ZM
Hang
D H
DH
Yang
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D000054:Acceleration; D000818:Animals; D001462:Barbital / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D006321:Heart / Q000502:physiology*; D006339:Heart Rate; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011312:Pressure; D011817:Rabbits; D013328:Strophanthins / Q000494:pharmacology; D016276:Ventricular Function
D013328:Strophanthins; D001462:Barbital; C029082:strophanthin K