Criteria for the validity of clinical trials of treatments of cohorts of cancer patients based on the Hardin Jones principle.
With the assumption of the validity of the Hardin Jones principle that the death rate of members of a homogeneous cohort of cancer patients is constant, three criteria for the validity of clinical trials of cancer treatments are formulated. These criteria are satisfied by most published clinical trials, but one trial was found to violate all three, rendering the validity of its reported results uncertain.
Linus Pauling Institute of Science and Medicine, Palo Alto, CA 94306.
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Pauling
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Herman
D001205:Ascorbic Acid / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000379:methods*; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000188:drug therapy; D015179:Colorectal Neoplasms / Q000188:drug therapy; D004311:Double-Blind Method; D006801:Humans; D015233:Models, Statistical; D009369:Neoplasms / Q000188:drug therapy*
D001205:Ascorbic Acid