Effect of a natural flavonoid on gastric mucosal barrier.
The effects of 3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-1-benzopyrylium chloride (IdB 1027) on the rat gastric mucosa were evaluated. IdB 1027 administered intragastrically at doses ranging from 100 to 400 mg/kg inhibited the fall in transmucosal potential difference and the increase in H+ back-diffusion induced by acetylsalicylic acid. Moreover, IdB 1027 at doses of 50 and 200 mg/kg by intragastric route increased the gastric bicarbonate secretion. These results suggest that the gastroprotective activity of IdB 1027 is mediated by an increase in the efficiency of gastric mucosal barrier.
Research and Development Laboratories, Inverni della Beffa, S.p.A., Milan, Italy.
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Cristoni
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Malandrino
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MJ
Magistretti
D000818:Animals; D000872:Anthocyanins; D001241:Aspirin / Q000378:metabolism; D001578:Benzopyrans / Q000502:physiology*; D001639:Bicarbonates / Q000378:metabolism; D002463:Cell Membrane Permeability; D004058:Diffusion; D005419:Flavonoids / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000872:Anthocyanins; D001578:Benzopyrans; D001639:Bicarbonates; D005419:Flavonoids; C017154:cyanidin; D001241:Aspirin