[Predictive and diagnostic value of fibronectin levels in pregnancy-induced hypertension].
Serum fibronectin (FN) level was assayed using ELISA monoclonal antifibronectin antibody of 152 normal gravida tested in the second and third trimesters, 24 cases who showed higher serum FN (309 +/- 13 mg/l, means +/- s means) than the normal (163 +/- 4 mg/l) developed pregnancy induced hypertension (PIH) later on. The serum FN level of 30 PIH patients was significantly higher than that of 128 normal gravidae (P less than 0.01). A serum FN level of 255 mg/l is suggested as the critical value in predicting the occurrence of PIH. The sensitivity was 79.2%, the specificity 95.3%, the index of diagnosis 174.5%, the efficiency of diagnosis 92.8%, the positive predictive value 76.0%, and the negative predictive value 96.1%.
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D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy
D005353:Fibronectins