The content of fatty acids in leukemic lymphocytes in vitro in cattle.
In leukemic lymphocytes in vitro obtained from cattle the fatty acids content has been determined employing the method of gas chromatography of methyl esters. Significant increase of linolic acid (C18 = 2) and of linolenic acid (C18 = 3) in leukemic lymphocytes have been noted, while reduced amounts of eicanoic acid (C20) and arachidonic acid (C20 = 4) have been observed. Fatty acids contribution in destabilization of biological membranes of leukemic cells has been discussed. It is very likely that the destabilization of biological membranes promotes the "induction" of various cancero- and cocancerogenetic changes, as well as enables the penetration of leukemovirus into the cell.
Madej
J A
JA
Department of Pathology nad Forensic Medicine, Agriculture Academy, Wrocław, Poland.
Szymczak
J
J
Klimentowski
S
S
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood*; D002849:Chromatography, Gas; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D005260:Female; D007938:Leukemia / Q000097:blood / Q000662:veterinary*; D008214:Lymphocytes / Q000032:analysis*; D012016:Reference Values
D005230:Fatty Acids, Nonesterified; D005231:Fatty Acids, Unsaturated