Adrenergic blocking agents and lipoprotein lipase activity.
Lipoprotein lipase activity, total serum cholesterol and triglycerides, HDL cholesterol were determined before and after two weeks of treatment with a low dose of an alpha 1-blocking agent (prazosin) or of a beta-adrenergic-blocking drug (metoprolol). Lipoprotein lipase activity was almost doubled after prazosin (p less than 0.02) and practically unchanged after metoprolol, at a time and at a drug dosage when only minor changes in blood pressure and serum lipids were detectable. HDL cholesterol was slightly but significantly increased after prazosin (p less than 0.05). Heart rate was increased after prazosin (p less than 0.05) and decreased after metoprolol (p less than 0.01).
Rubba
P
P
Istituto di Medicina Interna e Malattie Dismetaboliche, II Facoltà di Medicina, University of Napoli, Italy.
De Simone
B
B
Marotta
T
T
Leccia
G
G
Soro
S
S
Ferrara
L A
LA
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008071:Lipoprotein Lipase / Q000097:blood*; D008297:Male; D008790:Metoprolol / Q000494:pharmacology*; D008875:Middle Aged; D011224:Prazosin / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood*
D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol; D008071:Lipoprotein Lipase; D008790:Metoprolol; D011224:Prazosin