Oxidation and O-dealkylation of sulphamonomethoxine by the turtle Pseudemys scripta elegans.
Sulphamonomethoxine is O-demethylated at the 6 position and oxidised at the 2 position of the pyrimidine substituent by Pseudemys scripta elegans. No N4-acetylation takes place. The yield of the oxidation reaction is twice that of the O-demethylation reaction.
Vree
T B
TB
Department of Clinical Pharmacy, Sint Radboud Hospital, Nijmegen, The Netherlands.
Vree
J B
JB
Beneken Kolmer
N
N
Hekster
Y A
YA
Shimoda
M
M
Nouws
J F
JF
Yoshioka
T
T
Hoji
K
K
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D010084:Oxidation-Reduction; D013422:Sulfamonomethoxine / Q000493:pharmacokinetics*; D013424:Sulfanilamides / Q000493:pharmacokinetics*; D014426:Turtles / Q000378:metabolism*
D013424:Sulfanilamides; D013422:Sulfamonomethoxine