Influence of environmental factors on the in vitro efficacy of ciprofloxacin against anaerobic bacteria.
The effects of alterations in pH, size of inoculum, addition of human serum, and repeated exposure to sub-minimum inhibitory concentration of ciprofloxacin against anaerobic bacteria were assessed. Increase in the size of the inoculum and human serum had no effect on the minimum inhibitory concentration, whereas decrease in pH and exposure to sub-MIC decreased the activity of ciprofloxacin against Bacteroides fragilis. We tested for synergism of ciprofloxacin with cefoxitin, clindamycin and metronidazole against B. fragilis.
Department of Medicine, Charles R. Drew University of Medicine and Science/UCLA, School of Medicine.
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H
Thadepalli
M B
MB
Bansal
R
R
Marshall
R H
RH
Prabhala
D000900:Anti-Bacterial Agents; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001790:Blood Physiological Phenomena; D002939:Ciprofloxacin / Q000494:pharmacology*; D003470:Culture Media; D004359:Drug Therapy, Combination / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D003470:Culture Media; D002939:Ciprofloxacin