[Effects of furazolidone on brain monoamines in the treatment of peptic ulcer].
The purpose of this study was to investigate the protective role of furazolidone against the formation of duodenal ulcer induced by cysteamine and the effect of furazolidone on NE, DA and 5-HT concentrations in various brain regions (telencephalon, diencephalon and brainstem). The results indicated that one dose of cysteamine (280 mg/kg) produced 90-92% ulceration with no mortality within the first 24 hours, whereas cysteamine plus furazolidone significantly decreased the duodenal ulceration from 90% to 0. Using a sensitive spectrofluorimetric method, we found that cysteamine markedly diminished the NE levels in all regions but the DA level only in telencephalon. Meanwhile, cysteamine plus furazolidone increased the DA level in the same region. This suggested that the protective role of furazolidone against the formation of duodenal ulcer induced by cysteamine in rat may be related to increased DA level in telencephalon.
Huang
C W
CW
Zheng
Z T
ZT
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D003543:Cysteamine; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005664:Furazolidone / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D015306:Biogenic Monoamines; D005664:Furazolidone; D003543:Cysteamine