Effects of high- and low-osmolar contrast media on renal plasma flow and glomerular filtration rate in euvolaemic and dehydrated rats. A comparison between ioxithalamate, iopamidol, iohexol and ioxaglate.
The effects of a slow intravenous injection of contrast media (CM) on renal function and haemodynamics were investigated in euvolaemic and dehydrated rats. Iodine-equivalent doses (1600 mg I/kg body weight) of ioxithalamate, ioxaglate, iopamidol and iohexol were used. Glomerular filtration rate (GFR) and renal plasma flow (RPF) were assessed with clearance techniques. In euvolaemic rats no statistically significant decrease in GFR or RPF was found after CM injections. In the dehydrated rats the changes in GFR were more pronounced and this was significantly decreased in the ioxithalamate and iopamidol groups while RPF was still not decreased. This study indicates that dehydration potentiates adverse effects of CM on GFR and that there may be differences between the effects of low-osmolar and high-osmolar CM on GFR and also between different low-osmolar CM.
Department of Diagnostic Radiology, Akademiska Sjukhuset, University of Uppsala, Sweden.
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D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D003681:Dehydration / Q000503:physiopathology* / Q000652:urine; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D007472:Iohexol / Q000009:adverse effects; D007479:Iopamidol / Q000009:adverse effects; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D007485:Ioxaglic Acid / Q000009:adverse effects; D007668:Kidney / Q000098:blood supply*; D008297:Male; D009994:Osmolar Concentration; D051381:Rats
D003287:Contrast Media; D007483:Iothalamic Acid; D007472:Iohexol; C002587:ioxitalamic acid; D007479:Iopamidol; D007485:Ioxaglic Acid