Nimodipine does not improve neurologic outcome after 14 minutes of cardiac arrest in cats.
We tested the effects of nimodipine upon neurologic outcome in 31 cats subjected to 14 minutes of cardiac arrest followed by resuscitation. With the dose schedule used, nimodipine had no effect upon neurologic outcome or upon the percentage of ischemic neurons in frontal, hippocampal, occipital, or cerebellar brain sections. The electroencephalographic recovery pattern did not correlate with neurologic or pathologic findings.
Tateishi
A
A
Department of Anesthesiology, University of California, San Diego, La Jolla 92093.
Fleischer
J E
JE
Drummond
J C
JC
Scheller
M S
MS
Zornow
M H
MH
Grafe
M R
MR
Shapiro
H M
HM
D000818:Animals; D001921:Brain / Q000473:pathology; D002415:Cats; D002493:Central Nervous System Diseases / Q000517:prevention & control*; D004569:Electroencephalography; D006323:Heart Arrest / Q000188:drug therapy*; D009553:Nimodipine / Q000627:therapeutic use*; D012151:Resuscitation; D013997:Time Factors
D009553:Nimodipine