[Characteristics of the development of cataract models against a background of poisoning].
Biomicroscopic studies of lenses of 300 rabbits subjected to the action of various cataractogenic factors have shown that a combined action of cataractogenic factors (3-aminotriazole and light) as well as of cataractogenic and syncataractogenic factors (carbon tetrachloride) possess a much stronger action, that the isolated effect of such factors, as light of high intensity and 3-aminotriazole. It is shown that under combined action of 3-aminotriazole and carbon tetrachloride ripe cataract develops by the 42nd week and under combined action of light, aminotriazole and carbon tetrachloride--by the 30th week. The isolated action of aminotriazole and light doesn't induce ripe cataract. Aminotriazole produces pronounced cataractous changes 50-60 weeks after administration, the light--80 weeks after the action. A conclusion is made that opacification of the lens is a result of complex causes with many factors and is conditioned not only by photochemical processes in the lens itself and disturbances in the processes of detoxification of free radicals in the tissues of the eye as a whole and in the lens, in particular, but also by changes in the antiradical status of the body as a whole.
Shapkina-Gun'ko
V A
VA
Leus
N F
NF
Drozhzhina
G I
GI
D000640:Amitrole / Q000506:poisoning; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications* / Q000378:metabolism; D002386:Cataract / Q000209:etiology* / Q000378:metabolism; D004195:Disease Models, Animal; D005609:Free Radicals; D007908:Lens, Crystalline / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008027:Light / Q000009:adverse effects; D008297:Male; D011817:Rabbits; D013997:Time Factors
D005609:Free Radicals; D000640:Amitrole
Osobennosti razvitiia modelirovannykh katarakt na fone intoksikatsii.