A kinetic hairpin transfer model for parvoviral DNA replication.
The DNAs encapsidated by parvoviruses show distinctly different patterns with respect to the ratio of plus-to-minus strands and sequence heterogeneity at the ends. A kinetic model, based on differential rates of hairpin transfer at 3' termini, is described and shown to account for all known parvoviral DNA distributions.
Chen
K C
KC
Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061.
Tyson
J J
JJ
Lederman
M
M
Stout
E R
ER
Bates
R C
RC
D001483:Base Sequence; D003198:Computer Simulation; D004261:DNA Replication; D004279:DNA, Viral / Q000235:genetics*; D007700:Kinetics; D008433:Mathematics; D008957:Models, Genetic; D010321:Parvoviridae / Q000235:genetics*; D013816:Thermodynamics
D004279:DNA, Viral