Immunologic and hematologic responses in ponies with experimentally induced Strongylus vulgaris infection.
Immunologic and hematologic responses were examined in 4 ponies with experimentally induced Strongylus vulgaris infection and in 5 helminth-free ponies. Two ponies were inoculated with 200 larvae and 2 were inoculated with 700 larvae of S vulgaris and then were reinoculated with the same numbers of larvae 34 weeks later. Initial response of the ponies inoculated with S vulgaris was S vulgaris antigen-induced lymphocyte response that developed 1.5 to 3 weeks after inoculation and did not persist. Development of antigen-reactive lymphocytes was followed sequentially by a biphasic complement-fixing antibody response, then biphasic eosinophilia. Antibody titer to S vulgaris antigen was higher in ponies inoculated with 700 larvae, compared with that in ponies given 200 larvae of S vulgaris. Also, the second peak in antibody titer and in absolute number of eosinophils was observed earlier in ponies inoculated with 700 larvae, compared with ponies inoculated with 200 S vulgaris larvae, and subsided before or from about 24 weeks after inoculation. The prepatent period for S vulgaris infection was 24 to 25 weeks. After reinoculation with S vulgaris, a degree of increased lymphocyte responsiveness was apparent but, by 17 weeks after reinoculation, only the primary peak in the absolute number of eosinophils indicated an anamnestic response. Essentially, antibody was not detectable after reinoculation.
Department of Clinical Veterinary Medicine, University of Cambridge, England.
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Bailey
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Martin
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Lloyd
D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis*; D000947:Antigens, Helminth / Q000276:immunology; D003168:Complement Fixation Tests; D004802:Eosinophilia / Q000209:etiology / Q000662:veterinary; D005260:Female; D006403:Hematologic Tests / Q000662:veterinary; D006736:Horses / Q000469:parasitology; D007814:Larva / Q000276:immunology; D007958:Leukocyte Count / Q000662:veterinary; D008213:Lymphocyte Activation; D008297:Male; D011247:Pregnancy; D013319:Strongyle Infections, Equine / Q000276:immunology* / Q000469:parasitology; D013320:Strongyloidea / Q000276:immunology*; D013323:Strongylus / Q000276:immunology* / Q000302:isolation & purification
D000909:Antibodies, Helminth; D000947:Antigens, Helminth