Reversal of an aluminum-induced behavioral deficit by administration of deferoxamine.
Administration of aluminum sulfate in the drinking water of male Sprague-Dawley rats for 30 days resulted in a reduction in the number of days to reach extinction criterion on a passive avoidance task (38% control level). The behavioral deficit was not due to nonspecific effects caused by lower fluid consumption. Partial reversal of the deficit was produced by discontinuing aluminum treatment 2 weeks prior to testing (p less than .05). Injection of the aluminum chelator deferoxamine returned the performance of the aluminum-treated animals to control levels in a dose-dependent manner but had no effect on control animals. No differences in open-field activity were evident across groups. These results indicate that the behavioral impairment is a specific, reversible, toxic effect of the aluminum administration.
University of Alabama, Birmingham.
D J
DJ
Connor
L E
LE
Harrell
R S
RS
Jope
D000534:Alum Compounds / Q000633:toxicity*; D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003676:Deferoxamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000534:Alum Compounds; C041524:aluminum sulfate; D000535:Aluminum; D003676:Deferoxamine