[Synthesis and evaluation of the antifungal activity of a new series of N-acylureas].
Four new series of N-Acylureas (IIIa-h), (IV a-h), (Va-h), (VIa-h) were synthesized and tested for phytoiatric antimycotic activity. Only few of the tested compounds (IIIg), (IIIh), (IVf), (IVh), (Vg), (Vh), (VIg) showed a fairly good activity against P. irregulare, whereas no compounds exhibited any activity in the in vivo tests (in the preventive phase).
Departimento Di Scienze Farmaceutiche, Università Di Ferrara.
P G
PG
Baraldi
M
M
Guarneri
S
S
Manfredini
D
D
Simoni
V
V
Zanirato
D000935:Antifungal Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000935:Antifungal Agents; D014508:Urea
Sintesi e valutazione dell'attività antifungina di una nuova classe di N-aciluree.