Normotensive renal failure in systemic sclerosis.
Of 140 patients with "scleroderma renal crisis" encountered during a 33-year period, 15 of 131 (11%) whose blood pressures were recorded were normotensive during this complication. In comparison with 116 patients with hypertension, the normotensive patients significantly more often had microangiopathic hemolytic anemia (90% versus 38%) and thrombocytopenia (83% versus 21%). Pulmonary hemorrhage occurred in 6 normotensive patients. More normotensive patients had received high doses of corticosteroids (prednisone greater than or equal to 30 mg/day) during the 2 months immediately preceding renal crisis (64% versus 16%). A role for corticosteroids in precipitating renal crisis is suggested. The 12-month survival was significantly reduced in the normotensive patients (13% versus 35%).
Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261.
D J
DJ
Helfrich
B
B
Banner
V D
VD
Steen
T A
TA
Medsger
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D001794:Blood Pressure; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000473:pathology; D007668:Kidney / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects; D011446:Prospective Studies; D012189:Retrospective Studies; D012595:Scleroderma, Systemic / Q000150:complications* / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D012867:Skin / Q000473:pathology
D011241:Prednisone