Elevated plasma levels of haptoglobin in Duchenne muscular dystrophy:electrophoretic variants in patients with a severe form of the disease.
Analysis of plasma proteins of Duchenne muscular dystrophy (DMD) patients and normal age-matched boys using two dimensional gel electrophoresis and densitometry indicated a three-fold increase in the average haptoglobin level in DMD plasma. Two electrophoretic variants of haptoglobin in which the alpha 2 chain had more basic or more acidic spots were found in DMD patients with a rapidly progressing form of the disease. The basic variant was present in relatively low amount. Possible reasons for the elevated haptoglobin levels are discussed.
John
H A
HA
Department of Genetics, University of Edinburgh, Scotland.
Purdom
I F
IF
D002675:Child, Preschool; D003720:Densitometry; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D014644:Genetic Variation; D006242:Haptoglobins / Q000235:genetics / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D009136:Muscular Dystrophies / Q000097:blood*; D010449:Peptide Mapping
D006242:Haptoglobins; D006454:Hemoglobins; C035492:haptoglobin-hemoglobin complex