Hyperinsulinism in infancy.
Five infants with persistent hypoglycaemia due to hyperinsulinism were reported. Provocative tests for insulin release were unhelpful. Diazoxide was useful in the treatment of three patients but many side-effects were observed. These included petechial rash, hypertrichosis, acute renal failure, fluid retention and cardiac failure. Two patients underwent spontaneous remission. Three patients had nesidioblastosis, two of whom were subjected to 95% pancreatectomy. Postoperatively, recurrence of hypoglycaemia was due to hyperinsulinism in one patient and to presumed glucagon deficiency in the other. Phenytoin effectively corrected the hypoglycaemia in the patient who had postoperative hyperinsulinism. It is recommended that medical therapy with diazoxide (10-15 mg/kg per day) together with a diuretic be commenced once hyperinsulinism is diagnosed. Subtotal pancreatectomy should be performed early in these patients if hypoglycaemia cannot be controlled with medical therapy or if side-effects of treatment are documented.
Low
L C
LC
Department of Paediatrics, Queen Mary Hospital, Hong Kong.
Yu
E C
EC
Chow
O K
OK
Yeung
C Y
CY
Young
R T
RT
D003981:Diazoxide / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D007003:Hypoglycemia / Q000209:etiology*; D007231:Infant, Newborn; D008297:Male; D010179:Pancreas / Q000601:surgery; D010182:Pancreatic Diseases / Q000601:surgery
D004232:Diuretics; D003981:Diazoxide