Effect of cadmium on lipid peroxidation and antioxidant enzymes in undernourished weanling rat brain.
The effect of early postnatal cadmium exposure on lipid peroxidation and antioxidant enzymes in undernourished weanling rat brain has been studied. The results suggest that undernutrition makes the weanling rat brain more susceptible to the neurotoxic effects of cadmium. Cadmium at a low dose of 1 mg/kg body weight did not produce any changes in lipid peroxidation and antioxidant enzymes in normal weanling rat brain, but caused a significant increase in lipid peroxidation and markedly decreased the activities of antioxidant enzymes like glutathione peroxidase, superoxide dismutase and catalase when subjected to undernutrition.
Gill
K D
KD
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Pal
R
R
Nath
R
R
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000975:Antioxidants; D001921:Brain / Q000201:enzymology*; D002104:Cadmium / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism; D014886:Weaning
D000975:Antioxidants; D002104:Cadmium; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase