Udder edema in cattle: effects of diuretics (furosemide, hydrochlorothiazide, acetazolamide, and 50% dextrose) on serum and urine electrolytes.
Blood and urine chemical values at parturition in clinically normal Holstein cows (n = 12) were compared with the same values in Holstein cows developing udder edema (n = 12). There was no statistically significant mean difference between the 2 groups for the serum and urine chemical data. Furosemide (500 mg) given IV caused a significant increase in serum calcium and sodium, urine chloride, potassium, and sodium, and fractional excretional ratio of chloride, potassium, and sodium. There was a significant mean decrease in the serum potassium, urine creatinine, osmolality, pH, and specific gravity. Hydrochlorothiazide (250 mg) given IV caused a significant mean increase in serum chloride, urine chloride, potassium, and sodium, and fractional excretion ratio of chloride, potassium, and sodium. There was a significant mean decrease in serum potassium and sodium, urine osmolality, pH, and specific gravity. Acetazolamide (500 mg) given IV caused a significant mean increase in blood urea nitrogen, serum chloride and glucose, urine sodium, and fractional excretion ratio of sodium, while causing a significant mean decrease in serum potassium, sodium, and phosphorus, and urine creatinine. Dextrose (500 g) given IV as a 50% solution caused a statistical mean increase in serum glucose, urine chloride, potassium, and sodium, and fractional excretion ratio of chloride and potassium. A statistical mean decrease occurred in the packed cell volume, blood urea nitrogen, serum calcium, potassium, sodium, and phosphorus, urine creatinine, osmolality, and pH.
Vestweber
J G
JG
Department of Surgery and Medicine, College of Veterinary Medicine, Kansas State University, Manhattan 66506.
al-Ani
F K
FK
Johnson
D E
DE
D000086:Acetazolamide / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000097:blood / Q000652:urine; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004232:Diuretics / Q000494:pharmacology*; D004487:Edema / Q000097:blood / Q000652:urine / Q000662:veterinary*; D004573:Electrolytes / Q000032:analysis* / Q000097:blood / Q000652:urine; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006852:Hydrochlorothiazide / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008321:Mammary Glands, Animal; D009994:Osmolar Concentration; D011188:Potassium / Q000097:blood / Q000652:urine; D012964:Sodium / Q000097:blood / Q000652:urine; D013046:Specific Gravity
D004232:Diuretics; D004573:Electrolytes; D006852:Hydrochlorothiazide; D005665:Furosemide; D012964:Sodium; D005947:Glucose; D000086:Acetazolamide; D011188:Potassium; D002118:Calcium