Calmodulin-independent bovine brain adenylate cyclase. Amino acid sequence and nucleotide sequence of the corresponding cDNA.
An individual catalytic component of calmodulin-independent adenylate cyclase has been isolated from bovine brain cortex. Affinity chromatography on an immunosorbent was used. The amino acid sequence of adenylate cyclase as well as the corresponding nucleotide sequence of the cDNA has been determined. cDNA of adenylate cyclase encodes a protein consisting of 834 amino acid residues and the signal peptide (19 amino acid residues). A series of adenylate cyclase isoforms has been found. A homology between adenylate cyclases from bovine brain, E. coli and Bordetella pertussis has been revealed.
Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Moscow.
V M
VM
Lipkin
N V
NV
Khramtsov
S G
SG
Andreeva
M V
MV
Moshnyakov
G V
GV
Petukhova
T V
TV
Rakitina
E A
EA
Feshchenko
K A
KA
Ishchenko
S F
SF
Mirzoeva
M N
MN
Chernova
D000262:Adenylyl Cyclases / Q000235:genetics* / Q000302:isolation & purification; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002540:Cerebral Cortex / Q000201:enzymology*; D002846:Chromatography, Affinity; D003001:Cloning, Molecular; D004247:DNA / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D021382:Protein Sorting Signals / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
D021382:Protein Sorting Signals; D004247:DNA; D000262:Adenylyl Cyclases