Ultraviolet radiation-induced suppression of contact hypersensitivity in relation to padimate O and oxybenzone.
Contact hypersensitivity (CHS) in mice can be induced by cutaneous sensitization followed by elicitation via ear-painting with trinitrochlorobenzene (TNCB). This CHS reaction is systemic and can be suppressed by exposure of mice to suberythemogenic doses of 280-315 nm radiation. In this study, we investigated whether a commercially available water-resistant sunscreen, either SPF-6 or SPF-15, containing Padimate O (UVB absorber) and oxybenzone (UVA absorber), was effective in preventing systemic suppression of CHS induced by either FS36 sunlamp exposure or solar simulating radiation. We observed that these two sunscreen preparations were totally incapable of preventing the immunologic suppression of contact hypersensitivity by UV radiation. These results indicate that application of sunscreen does not retard the development of suppression of CHS following repeated UV exposure under conditions where erythema is not clinically observed. Thus, erythema may not be a good end point for assessing systemic immune suppression and its consequences.
Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia 30310-1495.
M S
MS
Fisher
J M
JM
Menter
I
I
Willis
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D062365:Aminobenzoates / Q000494:pharmacology*; D000818:Animals; D001577:Benzophenones / Q000494:pharmacology*; D003877:Dermatitis, Contact / Q000276:immunology*; D004307:Dose-Response Relationship, Radiation; D004890:Erythema / Q000209:etiology / Q000276:immunology; D007108:Immune Tolerance / Q000187:drug effects* / Q000528:radiation effects; D051379:Mice; D008812:Mice, Hairless; D013473:Sunscreening Agents / Q000494:pharmacology*; D014466:Ultraviolet Rays; D062366:para-Aminobenzoates
D062365:Aminobenzoates; D001577:Benzophenones; D013473:Sunscreening Agents; D062366:para-Aminobenzoates; C005290:oxybenzone; D010129:4-Aminobenzoic Acid; C041981:padimate-O