Influence of respiratory drive on airway responses to excitation of lung C-fibers.
To determine whether the responses of tracheal smooth muscle and the nasal vasculature to stimulation of lung C-fiber receptors depend on the level of respiratory drive, the effects of right atrial injection of capsaicin and phenyldiguanide were studied in chloralose-anesthetized, paralyzed, artificially ventilated cats. Studies were performed while the animals were hyperventilated to apnea and, in addition, when breathing was stimulated by inhalation of 7% CO2 or by N-methyl-D-aspartic acid (NMDA) applied to the ventral surface of the medulla. When the cats were hyperventilated to apnea with O2, injection of capsaicin into the right atrium increased tracheal tone and slightly raised nasal resistance. However, when the animals were ventilated with 7% CO2 in O2 or respiratory activity was stimulated by the application of NMDA, administration of capsaicin eliminated spontaneous phrenic nerve activity and caused an abrupt decrease in tracheal tone but still increased nasal resistance. Similar responses were also obtained with right atrial injection of phenyldiguanide. These results showed for the first time that in the cat the direction of the reflex effects on tracheal tone but not nasal resistance depends on the preexisting level of respiratory drive and on cholinergic activity to airway smooth muscle.
Department of Medicine, University Hospitals of Cleveland, Ohio.
M A
MA
Haxhiu
E C
EC
Deal
N S
NS
Cherniack
D000403:Airway Resistance; D000818:Animals; D001645:Biguanides / Q000494:pharmacology*; D002211:Capsaicin / Q000494:pharmacology*; D002415:Cats; D005260:Female; D008168:Lung / Q000294:innervation*; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D009297:Nasal Mucosa / Q000098:blood supply; D010791:Phrenic Nerve / Q000187:drug effects*; D012119:Respiration; D014132:Trachea / Q000187:drug effects*
D001645:Biguanides; D002211:Capsaicin; C008846:phenyl biguanide