Copper status and adriamycin treatment: effects on antioxidant status in mice.
The biochemical response of Cu-sufficient and Cu-deficient mice to adriamycin (ADR) treatment was evaluated. Mice were injected intraperitoneally with ADR (17 mg/kg body wt.) or saline (0.9% w/v) and killed 4 d after injection. There was no effect of ADR on cardiac superoxide dismutase (SOD) activity in Cu-sufficient of Cu-deficient mice. ADR injection resulted in higher cardiac glutathione (GSH) concentrations in Cu-sufficient mice while it resulted in lower GSH concentrations in Cu-deficient mice relative to their saline-injected controls. The effects of ADR in Cu-deficient mice were tissue-specific as its administration resulted in lower hepatic SOD activity and higher hepatic GSH concentrations relative to saline-injected controls.
Zidenberg-Cherr
S
S
Department of Nutrition, University of California, Davis 95616.
Dreith
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D
Keen
C L
CL
D000818:Animals; D001835:Body Weight; D003300:Copper / Q000172:deficiency / Q000378:metabolism*; D004317:Doxorubicin / Q000378:metabolism* / Q000633:toxicity; D004435:Eating; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051379:Mice; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D009929:Organ Size; D010084:Oxidation-Reduction; D013482:Superoxide Dismutase / Q000378:metabolism
D003300:Copper; D004317:Doxorubicin; D013482:Superoxide Dismutase; D005978:Glutathione