Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor.
RU 486, a steroid with high affinity for the progesterone receptor, is the first available active antiprogesterone. It has been used successfully as a medical alternative for early pregnancy interruption, and it also has other potential applications in medicine and for biochemical and pathophysiological endocrine research.
Baulieu
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INSERM U 33 (Communications hormonales), Faculté de Médicine, Université Paris-Sud, Bicêtre, France.
D000019:Abortifacient Agents / Q000627:therapeutic use*; D000021:Abortifacient Agents, Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D004334:Drug Administration Schedule; D010064:Embryo Implantation / Q000187:drug effects; D004963:Estrenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D005938:Glucocorticoids / Q000037:antagonists & inhibitors; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D015735:Mifepristone; D011247:Pregnancy / Q000187:drug effects; D011374:Progesterone / Q000037:antagonists & inhibitors*; D011965:Receptors, Glucocorticoid / Q000187:drug effects; D011980:Receptors, Progesterone / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000019:Abortifacient Agents; D000021:Abortifacient Agents, Steroidal; D004963:Estrenes; D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D011980:Receptors, Progesterone; D015735:Mifepristone; D011374:Progesterone; D007986:Luteinizing Hormone