An investigation into the incidence of auto-immune disorders in patients with localized morphoea.
Patients with localized morphoea have an increased incidence of auto-immune disorders, but this is not related to the age of onset, duration of disease nor the site or number of lesions. The patients have an increased incidence of tissue antibodies and these are more common when more than one lesion is present. The relatives of the patients have also been found to have an increased incidence of auto-immune disorders. These findings suggest an immunological basis for the disease and indicate that the patients should be investigated and followed up to detect the evidence of other auto-immune disorders.
Rupert Hallam Department of Dermatology, Royal Hallamshire Hospital, Sheffield, U.K.
C I
CI
Harrington
I R
IR
Dunsmore
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000150:complications* / Q000235:genetics / Q000276:immunology
D001323:Autoantibodies