A serotonin S2 antagonist, naftidrofuryl, exhibited a protective effect on ischemic neuronal damage in the gerbil.
The effect of a serotonin S2 antagonist, naftidrofuryl, on ischemic neuronal damage was examined in the gerbil. Naftidrofuryl was injected i.p. 5 min prior to a single 5-min forebrain ischemia or immediately after each of three 2-min forebrain ischemic insults at 60-min intervals. In both groups the number of intact hippocampal CA1 neurons were significantly higher than in the saline-treated group. These results indicate that serotonin S2 antagonists have a protective effect against ischemic neuronal damage.
Fujikura
H
H
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Kato
H
H
Nakano
S
S
Kogure
K
K
D000818:Animals; D002452:Cell Count; D005663:Furans / Q000627:therapeutic use*; D005849:Gerbillinae / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology*; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009257:Nafronyl / Q000627:therapeutic use*; D011985:Receptors, Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists
D005663:Furans; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D009257:Nafronyl