[Study of haemorheology in the process of invasion and metastasis after subcutaneous transplantation of mouse uterine cervix carcinoma U14].
Mouse uterine cervix carcinoma U14 was transplanted into 615-strain inbred mice. 13-14 animals were sacrificed on the 5th, 9th, 15th, and 19th day respectively. Histological and haemorheological studies were done for each mouse. Histological examination showed that tumor invasion was slight on the 5th day after transplantation (I-III grades). The invasive behaviour of tumor cells was more active on the 9th day after inoculation. On the 15th day, tumor invasive behaviour was obviously exhibited and lymphatic metastasis occurred in 17% of the cases. On the 19th day the invasive behaviour of tumor cells was over invasive grade III, and lymphatic metastasis was seen in all cases. Haemorheological investigation showed no remarkable change on the 5th day. Plasma viscosity, aggregation of red cells and blood viscosity increased significantly on the 9th day after transplantation. Contrarily, on the 15th and 19th day after transplantation, all the four haemorheological values showed significant, changes; namely, in the invasive stage, there was obvious increase in three haemorheological values; while in the metastatic stages all the four haemorheological values showed significant decrease. The results are discussed.
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D000818:Animals; D001809:Blood Viscosity; D004903:Erythrocyte Aggregation; D005260:Female; D008207:Lymphatic Metastasis; D051379:Mice; D008815:Mice, Inbred Strains; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D012212:Rheology; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000473:pathology