Preventive effect of taurine against acute paraquat intoxication in beagles.
The continuous infusion of taurine markedly protected against paraquat (PQ)-induced oliguria in beagles. Pharmacokinetic studies revealed that taurine infusion increased the blood concentration of PQ and reduced the net content in the kidney and, to a lesser extent, in the lung. The excretion of PQ into the urine was unaltered. The infusion of glycine did not have such effects.
Izumi
K
K
Department of Pharmacology, Faculty of Medicine, Kagoshima University, Japan.
Nagata
R
R
Motoya
T
T
Yamashita
J
J
Hirokane
T
T
Nagata
T
T
Satoh
Y
Y
Sawada
Y
Y
Ishibashi
M
M
Yoshida
H
H
D000818:Animals; D004285:Dogs; D005260:Female; D007262:Infusions, Intravenous; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D010269:Paraquat / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity; D013654:Taurine / Q000494:pharmacology*; D014563:Urodynamics / Q000187:drug effects
D013654:Taurine; D010269:Paraquat