A new HLA-B antigen, BHT: definition by serological and biochemical means.
In 3 unrelated individuals, a new, so far unknown HLA-B-locus antigen was found. This HLA-B antigen, provisionally termed 'BHT', is recognized by extra reactions with alloantisera against the B5 cross-reactive group. BHT can be clearly discerned from all cross-reactive antigens by one-dimensional isoelectro focusing (1D IEF), as it reveals, on IEF gels, a characteristic, rather neutral double-banding pattern different from all known HLA class I bands. The BHT banding pattern, which is identical in all 3 BHT-positive individuals, segregates with the haplotype A28, BHT, Cw7, DRw6.
Institute for Blood Group Serology, University of Vienna, Austria.
A
A
Hajek-Rosenmayr
L
L
Jungl
M
M
Kirnbauer
G
G
Gruber
W R
WR
Mayr
D005838:Genotype; D015235:HLA-B Antigens / Q000032:analysis* / Q000235:genetics; D006239:Haplotypes; D007106:Immune Sera; D007525:Isoelectric Focusing
D015235:HLA-B Antigens; D007106:Immune Sera