Anti-Staphylococcus aureus IgE antibodies for diagnosis of hyperimmunoglobulinemia E-recurrent infection syndrome in infancy.
Four infants with hyperimmunoglobulinemia E presented with a persistent papulovesicular rash and eosinophilia. Serum IgE levels and specific anti-Staphylococcus aureus IgE antibodies were studied during the first year of life. Increased anti-S aureus IgE antibodies were an early indicator of the disease; they appeared as soon as 7 weeks of age in patient 1 and before 1 year of age for the other patients. These antibodies were detected before the development of deeper staphylococcal infections. Prompt diagnosis and treatment are important, as they may prevent long-term infectious complications.
Department of Pediatrics, Children's Hospital, Philadelphia.
A
A
Lavoie
M
M
Rottem
M P
MP
Grodofsky
S D
SD
Douglas
D000914:Antibodies, Viral / Q000276:immunology*; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012008:Recurrence; D013207:Staphylococcal Skin Infections / Q000209:etiology / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology
D000914:Antibodies, Viral; D007073:Immunoglobulin E