Trisomy 16 detected at chorion villus sampling.
Trisomy 16 detected at chorion villus sampling (CVS) may reflect the placental but not the fetal karyotype. We describe a case in which the pregnancy continued until intrauterine death at 37 weeks. Cytogenetic study of two placental samples showed 47, + 16 and 46,XX; the fetus was morphologically grossly normal, but fetal tissue culture was unsuccessful. Conservative management may be appropriate when trisomy 16 is detected at CVS and the pregnancy is normal ultrasonographically.
Hashish
A F
AF
Department of Obstetrics and Gynaecology, Dunedin Hospital, New Zealand.
Monk
N A
NA
Lovell-Smith
M P
MP
Bardwell
L M
LM
Fiddes
T M
TM
Gardner
R J
RJ
D000328:Adult; D015193:Chorionic Villi Sampling; D002885:Chromosomes, Human, Pair 16 / Q000032:analysis*; D005260:Female; D005313:Fetal Death / Q000473:pathology; D006801:Humans; D011247:Pregnancy; D014314:Trisomy