Coronary artery plaque rapidly induced by local electromagnetic stimulation in the baboon.
A reliable method has been developed to produce stenosis of the right coronary artery of baboons as a consequence of electrostimulation of the vessel at a chosen position. At that site a pair of electrodes were implanted and activated with a train of 9-volt pulses (length: 10 ms, separation: 100 ms) for 30 min, 5 days/week, up to 6 weeks. 13 animals were included in the experiment, 2 of those served as controls. Pathohistologically the structure of the artificially produced constrictions is similar to atherosclerotic lesions. On average the stenoses occupied 55% of the available lumen; total occlusion and no stenosis were observed in 1 case each.
Breuer
H
H
Department of Cardiothoracic Surgery, University of Cape Town, South Africa.
Fincham
J
J
Hinrichsen
P
P
Uys
C J
CJ
Weich
H
H
Reichart
B
B
D000818:Animals; D003327:Coronary Disease / Q000209:etiology* / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004566:Electrodes; D055590:Electromagnetic Phenomena; D008297:Male; D010215:Papio