Pleural T-lymphocyte subsets in amiodarone-associated pleuropneumonitis.
Two male patients presented with lung disorders with all the characteristics of amiodarone-related pneumonitis. Bilateral exudative pleural effusions were associated with pneumonitis. High lymphocytosis was present in the pleural fluid with a ratio of T-lymphocyte subsets close to that found in peripheral blood; in the blood T-lymphocyte subset ratio was nearly normal. By contrast, and as is usual in similar cases, lymphocytic alveolitis with T-lymphocyte subset imbalance was found in bronchoalveolar lavage fluid. These findings, never published so far to our knowledge, would favor a compartmentalization of the immune response inside the lung.
Akoun
G M
GM
Chest Disease Department, Hôpital Tenon, Paris, France.
Milleron
B J
BJ
Badaro
D M
DM
Mayaud
C M
CM
Liote
H A
HA
D000368:Aged; D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000150:complications / Q000276:immunology; D000638:Amiodarone / Q000009:adverse effects*; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis; D006801:Humans; D008297:Male; D010996:Pleural Effusion / Q000209:etiology / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification*
D000638:Amiodarone