[Changes in the pulmonary surfactant system and induced chemiluminescence of pulmonary washings after fasting and the effect of alpha-tocopherol on them].
A complex of methods was used to study the pulmonary surfactant system and the intensity of induced chemoluminescence of pulmonary washings in rats after 4-week fasting and the effect produced on them by alpha-tocopherol. During fasting changes occurred in the values of surface activity of pulmonary washings, extracts, stability coefficient, and intensity of induced chemoluminescence; this was evidence of exhaustion of the intracellular surfactant reserve and intensification of lipid peroxidation. Administration of alpha-tocopherol during fasting reduced the disturbances in the pulmonary surfactant system of the animals and the degree of increased lipid peroxidation activity which indicates that the antioxidant protects the unsaturated fatty acids from oxidation.
Dorovatovskiĭ
V A
VA
Muravleva
L E
LE
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000378:metabolism*; D005215:Fasting; D008163:Luminescent Measurements; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology*
D011663:Pulmonary Surfactants; D014810:Vitamin E
Izmeneniia surfaktantnoĭ sistemy legkikh i indutsirovannoĭ khemiliuminestsentsii legochnykh smyvov posle golodaniia i vliianie na nikh alpha-tokoferola.