Enzymes of oxidant defence system of leucocytes and erythrocytes in bovine anaplasmosis.
The glutathione oxidant defence system in leucocytes and erythrocytes of six Anaplasma marginale-infected calves was examined by assaying glutathione peroxidase (GSH-px), glutathione reductase (GSSG-R), reduced glutathione (GSH) and superoxide dismutase (SOD). In addition, GSH-S-transferase and arginase levels were measured in leucocytes. There was a significant decline in the activities of leucocyte GSH-px, GSSG-R and SOD in the post-patent period; whereas arginase activity rose significantly following the patent period of anaplasmosis. The activity of erythrocyte SOD declined in the post-patent stage. The infection also caused a decline in red cell GSH (P less than 0.05). The results suggest that the glutathione oxidant defence system of peripheral blood cells is significantly influenced by the Anaplasma infection.
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Division of Biochemistry and Food Science, Indian Veterinary Research Institute, U.P., India.
Reddy
G R
GR
Sharma
S P
SP
Singh
L N
LN
D000712:Anaplasmosis / Q000201:enzymology* / Q000276:immunology; D000818:Animals; D001119:Arginase / Q000097:blood; D002417:Cattle; D002418:Cattle Diseases / Q000201:enzymology* / Q000276:immunology; D004912:Erythrocytes / Q000201:enzymology*; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D007962:Leukocytes / Q000201:enzymology*; D008297:Male; D010084:Oxidation-Reduction; D013482:Superoxide Dismutase / Q000097:blood
D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D001119:Arginase; D005978:Glutathione