Inhibition of carrageenin paw edema by pyridinalalkylimine rhodium(I) complexes.
The effects of a series of pyridinalalkyl-1,5-cyclooctadiene Rhodium(I) complexes were studied on the carrageenin paw edema model, using Sprague-Dawley rats. The series of compounds used were administered at 35, 70 and 140 mumol/kg i.p. 1hr before carrageenin application, and the effect was measured 4hr after carrageenin. The 1,5-cyclooctadienepyridinalaldoxime Rhodium(I) complex proved to be the most active compound, effective also when administered 1hr after carrageenin induction of paw swelling. However, the effects of this complex are not superior to those reported for the methyl derivative, and the overall antiinflammatory activity is inferior to that of this latter compound, particularly when the number of dosages causing at least 80% inhibition are compared. These data are consistent with those obtained in a previous investigation indicating that Rhodium(I) complexes have potential antiinflammatory properties, susceptible of further investigations extended also to other models of inflammatory disease.
Sava
G
G
Institute of Pharmacology, Faculty of Pharmacy, University of Trieste, Italy.
Pacor
S
S
Ceschia
V
V
Zassinovich
G
G
Mestroni
G
G
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002351:Carrageenan; D004487:Edema / Q000517:prevention & control*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012238:Rhodium / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D012238:Rhodium