Identification and quantification of p-hydroxyethylamphetamine as a novel metabolite of ethylamphetamine in rat by gas chromatography-mass spectrometry.
Ethylamphetamine and two major metabolites in urine, obtained after intraperitoneal administration of the drug to rats, have been isolated by gas chromatography-mass spectrometry. We have also synthesized an authentic sample of p-hydroxy-N-ethylamphetamine by a simple method. In rat, the metabolic pathway of ethylamphetamine is similar to that of amphetamine and methylamphetamine according to quantitative analysis of the major metabolites using a selected ion monitoring (SIM) method.
Faculty of Pharmaceutical Sciences, University of Tokyo Hongo, Japan.
Y
Y
Makino
T
T
Higuchi
S
S
Ohta
M
M
Hirobe
D000661:Amphetamine / Q000652:urine; D000662:Amphetamines / Q000138:chemical synthesis / Q000378:metabolism* / Q000652:urine*; D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000662:Amphetamines; C016434:ethylamphetamine; C060891:4-hydroxyethylamphetamine; D000661:Amphetamine