Clustering of multiple sclerosis in Galion, Ohio, 1982-1985.
Epidemiologic evidence indicates that the outbreak of 30-40 cases of multiple sclerosis and other demyelinating syndromes in Galion, Ohio, USA, during 1982-1985 was related to an excess concentration of heavy-metal wastes, especially of cadmium and chromium in sewage and river water. Both multiple sclerosis and myasthenia gravis were diagnosed by board-certified neurologists.
School of Public Health, Boston University School of Medicine, Massachusetts.
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D000690:Amyotrophic Lateral Sclerosis / Q000139:chemically induced / Q000453:epidemiology; D002104:Cadmium / Q000032:analysis; D002105:Cadmium Poisoning; D002857:Chromium / Q000032:analysis / Q000506:poisoning; D003300:Copper / Q000032:analysis / Q000506:poisoning; D004196:Disease Outbreaks; D005618:Fresh Water; D006801:Humans; D008670:Metals / Q000032:analysis / Q000506:poisoning*; D009103:Multiple Sclerosis / Q000139:chemically induced / Q000453:epidemiology*; D009157:Myasthenia Gravis / Q000139:chemically induced / Q000453:epidemiology; D009820:Ohio; D014873:Water Pollutants / Q000506:poisoning*; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000506:poisoning*
D008670:Metals; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D002104:Cadmium; D002857:Chromium; D003300:Copper