Inhibition of collagen synthesis by interleukin-1 in three-dimensional collagen lattice cultures of fibroblasts.
Interleukin-1 (Il-1) was added to collagen lattice cultures of human skin fibroblasts. No cell division was induced, the ability of fibroblasts to contract the lattices was decreased and a dose-related inhibition of collagen synthesis without effect on non-collagen proteins was found. Indomethacin had no influence on these effects.
Lab. Biochemistry, UA CNRS 610, Fac. Medicine, Reims, France.
P
P
Gillery
F
F
Coustry
J P
JP
Pujol
J P
JP
Borel
D002452:Cell Count; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D003470:Culture Media; D005109:Extracellular Matrix; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007375:Interleukin-1 / Q000494:pharmacology*; D014176:Protein Biosynthesis
D003470:Culture Media; D007375:Interleukin-1; D003094:Collagen; D007213:Indomethacin