Cell response in bronchoalveolar lavage fluid after sulfur dioxide exposure.
Environmental chamber exposure and bronchoalveolar lavage (BAL) were used to study the dose-response relationship between short-term exposure to sulfur dioxide (SO2) and inflammatory reactions in the human lung as reflected in BAL fluid. Healthy subjects were exposed to 10, 13, 20, or 30 mg/m3 for 20 min. BAL was performed several weeks preexposure and 24 h postexposure. Mast cells, lymphocytes, lysozyme positive macrophages, and the total number of macrophages were significantly increased after SO2 exposure. A dose-dependent increase in the cell response in BAL fluid was observed after exposure to 10-20 mg/m3, but no further increase was detected after 30 mg/m3. Inflammatory cell response was found in BAL fluid at SO2 levels that occur in industrial indoor environments worldwide, and cell response to SO2 was also seen below the short-term exposure limit of Sweden and many other countries (13 mg/m3).
Department of Lung Medicine, University Hospital, Umeå, Sweden.
T
T
Sandström
N
N
Stjernberg
M C
MC
Andersson
B
B
Kolmodin-Hedman
K
K
Lindström
L
L
Rosenhall
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D001999:Bronchoscopy; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007958:Leukocyte Count; D008168:Lung / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D011014:Pneumonia / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D013147:Spirometry; D013458:Sulfur Dioxide / Q000008:administration & dosage*
D013458:Sulfur Dioxide