Plasma fibrinolytic activity after ingestion of omega-3 fatty acids in human subjects.
Plasma fibrinolytic activity was measured in human volunteers after 30 day periods of ingestion of a fish oil product (Max Vita) containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and a wheat germ oil product containing alpha linolenic acid. Compliance was confirmed by significant increases in plasma levels of EPA and DHA and by significant falls in serum triglyceride levels. Platelet aggregation in platelet rich plasma and in whole blood was not altered significantly by fish oil or wheat germ oil. Neither fish oil or wheat germ oil caused any significant change in tissue plasminogen activator (tPA) or its inhibitor (PAI) measured enzymatically or in tPA antigen measured by an ELISA method. All these analytes (tPA, PAI, and tPA antigen) were measured before and after venous compression.
Department of Pathology, Michael Reese Hospital and Medical Center, Chicago, Illinois.
G
G
Takimoto
J
J
Galang
G K
GK
Lee
B A
BA
Bradlow
D000328:Adult; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D005395:Fish Oils / Q000494:pharmacology*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects
D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D008055:Lipids