Focal glomerulosclerosis treated with heparin.
A boy with focal glomerulosclerosis as a result of nephrotic syndrome became unresponsive to corticosteroids and cyclophosphamide. He was given prolonged subcutaneous heparin with reduction in proteinuria, return of corticosteroid sensitivity, and no further deterioration (possibly improvement) in histological appearance. He remained completely well after five years.
Department of Paediatrics, Flinders University of South Australia.
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Coleman
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Gallus
D002648:Child; D005921:Glomerulonephritis / Q000188:drug therapy*; D005923:Glomerulosclerosis, Focal Segmental / Q000188:drug therapy* / Q000209:etiology; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications
D006493:Heparin