Study of the disposition kinetics of the N-oxide-derivative: a metabolite of picobenzide.
The disposition kinetics of the N-oxide of picobenzide were studied after administration to rabbits at a bolus dose of 30 mg/kg of picobenzide intravenously. The biotransformation process fits a first-order kinetic process, and the metabolite shows good access capacity to the peripheral compartment. The N-oxide of picobenzide was determined by D.P.P. and parametric estimation was performed by the SIMPLEX method as the search algorithm.
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Salamanca, Spain.
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Santos Buelga
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Mariño
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Domínguez-Gil
D000818:Animals; D001549:Benzamides / Q000493:pharmacokinetics*; D001711:Biotransformation; D007202:Indicators and Reagents; D007275:Injections, Intravenous; D008954:Models, Biological; D011048:Polarography; D011817:Rabbits
D001549:Benzamides; D007202:Indicators and Reagents; C024323:picobenzide N-oxide; C016938:picobenzide