[Features of protein secretion by the rat liver in various stages of carbon tetrachloride or heliotrine poisoning].
Rats were poisoned by carbon tetrachloride (50% oil solution; 0.5 ml/100 g; 12 injections) or by heliotrine (0.5 mg/100 g once a week; 10 injections). In periods of 3 to 12 months from the onset of poisoning, the liver was perfused in situ with Tyrode's solution and polyglucin for 5 hours. Protein was determined in the perfusate. In the first 3 hours of perfusion stimulation of protein synthesis was absent (basal secretion), then 500 mcg/l cortisol was added (stimulated protein secretion). Progressive decrease in basal and stimulated secretion of protein was encountered in heliotrine poisoning. In poisoning by carbon tetrachloride stimulated secretion decreases progressively, while basal secretion reduces in the initial stages of perfusion but begins to be activated by the 12th month after the onset of poisoning.
K T
KT
Tadzhibaev
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D011763:Pyrrolizidine Alkaloids / Q000506:poisoning*; D051381:Rats
D011506:Proteins; D011763:Pyrrolizidine Alkaloids; C010178:heliotrine
Osobennosti sekretsii belka pechen'iu krys na raznuykh stadiiakh otravleniia CCl4 ili geliotrinom.