Inhibitors of adenosine catabolism improve recovery of dog myocardium after ischemia.
The effects of inhibitors of adenosine catabolism on contractile function and metabolites were assessed during 15 minutes of ischemia followed by 30 minutes of reperfusion in the open-chest dog heart. As compared to sham treatment, pretreatment with erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and dipyridamole (DP) protected contractile function during ischemia, and improved recovery of high energy phosphate content and contractile function during reperfusion following ischemia. Testing EHNA and DP in a free-radical generating system indicated both compounds have some scavenging ability, suggesting the effect of EHNA + DP may not be on adenosine nucleotide metabolism alone. Comparison of end diastolic segment lengths to contractile function indicated the results were not affected by changes in preload resulting from peripheral vasodilation.
Koke
J R
JR
Department of Biology, Southwest Texas State University, San Marcos.
Fu
L M
LM
Sun
D
D
Vaughan
D M
DM
Bittar
N
N
D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D004176:Dipyridamole / Q000627:therapeutic use*; D004285:Dogs; D004338:Drug Combinations; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D005609:Free Radicals; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*
D004338:Drug Combinations; D005609:Free Radicals; C010192:9-(2-hydroxy-3-nonyl)adenine; D004176:Dipyridamole; D000225:Adenine; D000241:Adenosine