[Pulmonary eosinophilic infiltration with pneumothorax during trimipramine treatment].
Three weeks after starting treatment with the antidepressant trimipramine a 55-year-old man developed increasing cough, fatigue and lack of appetite. The blood count revealed marked eosinophilia (15%) and the chest X-ray showed bilateral pulmonary infiltrates. Later a left spontaneous pneumothorax occurred. When trimipramine was discontinued (as the suspected cause of the described changes) the symptoms quickly subsided and the infiltrate as well as the eosinophilia quickly disappeared.
Medizinische Klinik, Kantonsspital Chur.
A K
AK
Eigenmann
M
M
Kuhn
D003984:Dibenzazepines / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011030:Pneumothorax / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography; D013997:Time Factors; D014299:Trimipramine / Q000008:administration & dosage / Q000009:adverse effects*
D003984:Dibenzazepines; D014299:Trimipramine
Eosinophiles Lungeninfiltrat mit Pneumothorax während Trimipramin-Behandlung.