[Changes in the electrical activity of spinal cord neurons of adrenalectomized rats under the effect of adrenal cortex hormones].
Effect of dexamethasone and desoxycorticosterone on the electrical activity of neurons in dorsal and ventral horn of spinal cord evoked by sciatic nerve stimulation were studied in adrenalectomized rats as well as effect of the same hormones on the background activity of single cells in the dorsal horn. The results demonstrated that both hormones (dexamethasone and desoxycorticosterone) provided enhancement of the amplitude of the field potentials recorded from the dorsal half of the spinal cord and facilitation of the background neuronal discharges of the single cells under investigation. It was stated that gluco- and mineralocorticoid hormones exerted different effects on the activity of ventral horn neurons of the spinal cord: dexamethasone++ potentiated and desoxycorticosterone depressed the amplitudes of the field potentials recorded from the region of motoneurons. The presented data have shown the modulatory effects of neurosteroids on the electrical activity of the spinal cord neurons.
Kapriian
T K
TK
Chavushian
V A
VA
D000315:Adrenalectomy; D000818:Animals; D003900:Desoxycorticosterone / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D005071:Evoked Potentials; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects / Q000502:physiology*
D003900:Desoxycorticosterone; D003907:Dexamethasone
Izmeneniia élektricheskoĭ aktivnosti neĭronov spinnogo mozga adrenaléktomirovannykh krys pod deĭstviem gormonov kory nadpochechnikov.