Hereditary nature of the pattern of the motor activity circadian rhythm in mice.
The inherited nature of the pattern of the daily motor activity function (MAF) has been studied using different families of the same strain of mice. The motor activity of 6 male mice, belonging to two different families (A and B was recorded during 54 days in LD conditions (12L:12D) using six inductive units. The register began the day just after weaning. A Fourier analysis was applied to motor activity data corresponding to observation periods of 24 hours. The daily power spectrum, with 20 harmonics, was calculated by obtaining the power content of each harmonic expressed as a percentage of the total power content of the MAF. A discriminant function based on the first fifteen harmonics was created to distinguish between the males of the two families. Then, the same discriminant function was applied to the daily power spectra of the progeny. It was also possible to differentiate among the mice (males and females) coming from fathers of family A and the mice coming from fathers of family B (p less than 0.02). This fact suggests that, in the power spectra of the progeny, there may be enough characteristic equal to that of their respective fathers and it further suggests that some characteristic of the MAF could have been inherited.
Departament Ciències Fisiològiques Humanes i de la Nutrició, Facultat Farmàcia, Universitat de Barcelona, Spain.
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Díez-Noguera
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Cambras
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Ribot
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Torralba
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002940:Circadian Rhythm; D005260:Female; D008297:Male; D051379:Mice / Q000235:genetics*; D009043:Motor Activity / Q000502:physiology*