The influence of corticosteroids on sequential clinical and synovial fluid parameters in joints with acute infectious arthritis in the horse.
Infectious arthritis was induced experimentally in one tarsocrural joint of six horses by intra-articular injection of 1 ml Staphylococcus aureus-saline suspension with the addition of 200 mg methylprednisolone acetate. The corresponding contralateral joint was injected with 1 ml of saline with the addition of 200 mg methylprednisolone acetate, and served as a control. The purpose of the experiment was to examine the effect of corticosteroids on the acute clinical signs of infectious arthritis, and the associated changes in synovial fluid, to separate the effects of a steroid injection from those of infection alone. This should aid early diagnosis of infection. The progression of the infectious arthritis was assessed over nine days by clinical examination and sequential synovial fluid analysis. The corticosteroids masked the clinical signs in some horses for up to the third day although changes in the synovial fluid were present earlier. Cellular changes preceded biochemical changes initially. Leucocyte counts showed a significant increase in cell numbers after infection was established. Persistent neutrophilia, over 90 per cent, together with a pH under 6.9 were the most consistent findings in the infected synovia. Total protein values were lower in infected joints with, than those without, corticosteroids; although there was a progressive rise in total protein concentration throughout the experiment in both groups. Serum and synovial glucose difference and synovial lactate had very little diagnostic value because significant increases due to the corticosteroids were documented in the control joints.
College of Veterinary Medicine, Department of Clinical Sciences, Helsinki, Finland.
R M
RM
Tulamo
L R
LR
Bramlage
A A
AA
Gabel
D000208:Acute Disease; D000818:Animals; D001170:Arthritis, Infectious / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D001786:Blood Glucose / Q000032:analysis; D005947:Glucose / Q000032:analysis; D006734:Horse Diseases / Q000175:diagnosis* / Q000188:drug therapy; D006736:Horses; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000032:analysis; D007794:Lameness, Animal / Q000209:etiology; D007958:Leukocyte Count; D008775:Methylprednisolone / Q000627:therapeutic use*; D009504:Neutrophils; D011506:Proteins / Q000032:analysis; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D013582:Synovial Fluid / Q000032:analysis* / Q000166:cytology / Q000382:microbiology
D001786:Blood Glucose; D007773:Lactates; D011506:Proteins; D005947:Glucose; D008775:Methylprednisolone