Disposition and dosage regimen of cephaloridine in calves.
The disposition and dosage regimen of cephaloridine were investigated in healthy calves following a single intramuscular administration of 10 mg/kg. The absorption halflife, elimination halflife, apparent volume of distribution and total body clearance were 0.107 +/- 0.025 h, 2.08 +/- 0.14 h, 0.70 +/- 0.07 L kg-1 and 235.8 +/- 21.9 ml kg-1 h-1, respectively. Therapeutic plasma levels (greater than or equal to 1 micrograms/ml) were maintained for up to 7 h. A satisfactory intramuscular dosage regimen for cephaloridine in calves would be 10 mg/kg repeated at 8 h intervals.
Department of Pharmacology, College of Veterinary Science, Punjab Agricultural University, Ludhiana, India.
R K
RK
Chaudhary
A K
AK
Srivastava
D000818:Animals; D001682:Biological Availability; D002417:Cattle / Q000378:metabolism*; D002509:Cephaloridine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D007273:Injections, Intramuscular; D007275:Injections, Intravenous
D002509:Cephaloridine