Effects of sennosides A + B and bisacodyl on rat large intestine.
Oral and intracecal administration of bisacodyl or sennosides A + B (10-100 mg/kg each) to rats induced a similar quantity of soft feces within 24 h and a similar acceleration of large intestinal transit time, but in each case bisacodyl had a prolonged action. Net fluid absorption in the perfused rat colon was reduced to a comparable extent by local bisacodyl in 1/10 of the molar concentration of rhein, an active metabolite of sennosides; recovery was delayed after bisacodyl. These results show that the time course of the laxative action of both drugs is different, probably attributable to their different pharmacokinetics. Both drugs influence colon motility as well as colonic secretion, but fluid secretion may contribute more to the laxative effect of bisacodyl than to that of sennosides.
Department of Pharmacology, Dr. Madaus GmbH & Co., Köln, FRG.
E
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Leng-Peschlow
D000284:Administration, Oral; D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology*; D001726:Bisacodyl / Q000494:pharmacology*; D001834:Body Water / Q000378:metabolism; D002400:Cathartics / Q000494:pharmacology*; D003106:Colon / Q000378:metabolism; D003408:Cresols / Q000494:pharmacology*; D004573:Electrolytes / Q000378:metabolism; D005243:Feces; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects; D007408:Intestinal Absorption / Q000187:drug effects; D007420:Intestine, Large / Q000187:drug effects*; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D012676:Senna Extract; D000081226:Sennosides
D000880:Anthraquinones; D002400:Cathartics; D003408:Cresols; D004573:Electrolytes; D000081226:Sennosides; D001726:Bisacodyl; D012676:Senna Extract; D009247:NADH, NADPH Oxidoreductases; C020491:rhein