Male fertility study on N,N-dimethylacetamide administered by the inhalation route to Sprague-Dawley rats.
Male Sprague-Dawley rats were exposed to N,N-dimethylacetamide (DMAC) and mated to untreated virgin females. Mean analytical exposure concentrations were 40, 116, and 386 ppm, respectively. A control group was exposed to air containing no DMAC. A total of 69 d of exposure to DMAC at these levels produced treatment-related effects of increased liver weights and liver/body weight ratios in the high- and medium-exposure groups of male rats. Reproductive data indicated no treatment-related effects on copulation efficiency or efficiency in effecting pregnancy, and there were no detectable treatment-related effects on preimplantation loss, postimplantation loss, embryotoxicity, or fetotoxicity in litters of females mated to males exposed to DMAC at the levels used in this study. The significance of these findings is discussed.
California Department of Food and Agriculture, Sacramento.
G M
GM
Wang
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LD
Kier
G W
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Pounds
D000081:Acetamides / Q000008:administration & dosage / Q000633:toxicity*; D000280:Administration, Inhalation; D000818:Animals; D001284:Atrophy; D003451:Cryoprotective Agents / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013737:Testis / Q000187:drug effects / Q000473:pathology
D000081:Acetamides; D003451:Cryoprotective Agents; C013959:dimethylacetamide