Pseudallescheria boydii keratomycosis in a horse.
The fungal organism Pseudallescheria boydii was isolated from the cornea of a Quarter Horse with ulcerative keratitis. Despite aggressive hourly medication through a subpalpebral lavage system, with drugs including miconazole and natamycin, the cornea developed a stromal abscess. Orbital exenteration was performed after 3 weeks. The fungal isolate was later determined to be resistant to all 8 antifungal drugs tested. Microscopic examination of the cornea revealed fungal hyphae throughout the corneal stroma and penetrating the Descemet membrane. Pseudallescheria boydii has not been implicated previously as a cause of keratomycosis in horses or in other domestic animals, although cases in human beings have been described.
Friedman
D S
DS
Department of Surgical Sciences, Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
Schoster
J V
JV
Pickett
J P
JP
Dubielzig
R R
RR
Czuprynski
C
C
Knoll
J S
JS
Wolfgram
L J
LJ
D000818:Animals; D001203:Ascomycota / Q000302:isolation & purification*; D006734:Horse Diseases / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology; D006736:Horses; D007634:Keratitis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009181:Mycoses / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D011541:Pseudallescheria / Q000302:isolation & purification*