[Effect of carminomycin on the enzyme systems of the metabolism of active forms of oxygen and on free-radical lipid oxidation in August rats with Walker carcinosarcoma 256].
The influence of carminomycin (CM) on enzymic systems of metabolism of oxygen active forms, free radical lipid peroxidation and microviscosity of membrane lipids as well as toxic and antitumour action of CM were studied in normal and tumour-bearing rats. Detected responses of the system of superoxide anion- and H2O2 metabolism reflected the role of active oxygen forms in CM toxicity. The investigation results of the lipid peroxidation fluorescent products level and microsomal lipid phase microviscosity did not suppose stimulation of lipid peroxidation as key mechanism for CM toxic effects. Problems on the prevention and treatment of anthracyclines side effects are discussed.
Sh S
ShS
Tazhibaev
E G
EG
Lenskaia
K Kh
KKh
Khasenova
N M
NM
Karsybekova
N R
NR
Alekseeva
D000818:Animals; D002279:Carcinoma 256, Walker / Q000188:drug therapy* / Q000378:metabolism; D002360:Carubicin / Q000627:therapeutic use* / Q000633:toxicity; D002374:Catalase / Q000378:metabolism; D003630:Daunorubicin / Q000031:analogs & derivatives*; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009368:Neoplasm Transplantation; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D014783:Viscosity
D005609:Free Radicals; D008563:Membrane Lipids; D002360:Carubicin; D002374:Catalase; D013482:Superoxide Dismutase; D003630:Daunorubicin
Vliianie karminomitsina na fermentnye sistemy metabolizma aktivnykh form kisloroda i svobodnoradikal'noe okislenie lipidov u krys linii August s kartsinosarkomoĭ Uoker 256.