[Patterns in the combined action of irradiation and glucose loading on tumor cells].
It was shown that incubation of Ehrlich ascites tumor cells with glucose or in buffer solutions of low pH decreases their viability. The cell survival rate depends on pH values irrespective of the protoxidation method and oxygenation conditions used. At the same time, radiosensitivity of Ehrlich ascites tumor cells is practically invariable with pH being decreased from 7.0 to 5.0. The effects of glucose and radiation are additive in conditions simulating the effect of hyperglycaemia in vivo.
Shmakova
N L
NL
Shteĭn
L V
LV
Kolesnikova
A I
AI
Fomenkova
T E
TE
Lepekhina
L A
LA
D000818:Animals; D002021:Buffers; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism / Q000532:radiotherapy*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003131:Combined Modality Therapy / Q000379:methods; D005720:Gamma Rays / Q000627:therapeutic use; D005947:Glucose / Q000627:therapeutic use*; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D010101:Oxygen Consumption / Q000187:drug effects / Q000528:radiation effects; D011838:Radiation-Sensitizing Agents; D013997:Time Factors; D014407:Tumor Cells, Cultured
D002021:Buffers; D011838:Radiation-Sensitizing Agents; D005947:Glucose
Zakonomernosti kombinirovannogo deĭstviia oblucheniia i gliukoznoĭ nagruzki na opukholevye kletki.