[Diabetic neuropathy in dogs and cats--a bioptic electron microscopic study].
Electron microscopic examination of peripheral nerves within dermal corium based upon skin biopsies (punch diameter = 6 mm) of chronic diabetic dogs and cats in comparison with normal controls revealed that more than 90% of the diabetic animals (31/34 dogs, 9/10 cats) had developed characteristic neuropathies. The main features were of axonal atrophy of myelinated and unmyelinated fibers, demyelination and - to a lesser degree - intraaxonal accumulation of glycogen (about 25%). In contrast with human diabetic polyneuropathy vascular basement membranes were throughout of normal appearance. Thickening of the perineural basement membranes were observed in a few canine cases only. Diagnostic procedures as well as questions on pathogenesis are discussed in detail.
Lehrstuhl für Allgemeine Pathologie und Neuropathologie, Tierärztlichen Fakultät der Ludwig-Maximilians-Universität München.
E
E
Dahme
A
A
Hafner
C
C
Reusch
P
P
Schmidt
D000818:Animals; D001284:Atrophy; D001369:Axons / Q000473:pathology / Q000648:ultrastructure; D001485:Basement Membrane / Q000648:ultrastructure; D001706:Biopsy / Q000662:veterinary; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D003711:Demyelinating Diseases / Q000473:pathology / Q000662:veterinary; D003929:Diabetic Neuropathies / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000473:pathology / Q000648:ultrastructure; D010525:Peripheral Nerves / Q000473:pathology / Q000648:ultrastructure*; D012867:Skin / Q000294:innervation / Q000473:pathology
Diabetische Neuropathie bei Hund und Katze--eine bioptisch-elektronenmikroskopische Studie.