[HLA-A, B-antigens and hypertrophic cardiomyopathy].
21 HLA-A, B-antigens were typed in 82 patients with hypertrophic cardiomyopathy and their 17 diseased relatives in 15 families, and their frequency was statistically compared with 300 healthy persons. A statistically significant lower frequency of the HLA-antigen B35 could bei stated (3.66% in contrast to 19.33%). An insignificant occurrence of HLA-B40 and a more frequent occurrence of HLA-Bw22 were statistically significant only before the p-correction. A statistic evaluation was done also in the groups of patients who were subdivided according to the age, the breadth of the ventricular septum and the presence of the obstruction. The importance of the results for the pathogenesis and prognosis of the disease was discussed.
Institut für Hämatologie und Bluttransfusion, Medizinischen Hygiene-Fakultät Prag.
A
A
Májský
P
P
Gregor
J
J
Prazák
D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000235:genetics* / Q000473:pathology; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006239:Haplotypes; D006346:Heart Septum / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors
D015234:HLA-A Antigens; D015235:HLA-B Antigens
HLA-A, B-Antigene und hypertrophische Kardiomyopathie.