[Participation of the lungs in the absorption and liberation of biogenic amines in the postresuscitation period].
After revival from a 10-minute clinical death caused by acute blood loss the transport of biogenic amines to the lungs in dogs did not increase for 3 hours. Their absorption by the lungs was replaced periodically by their liberation; both processes were intensified for serotonin but weakened for histamine. In 6-9 hours during the period of hypoperfusion and reduction of the transport of amines to the lungs the intensity of absorption and liberation of serotonin by the lungs were normalized, while these processes for histamine remained diminished. The content of biogenic amines in arterial blood reduced. Twenty-four hours later, under conditions of normalization of hemodynamics, the transport of histamine to the lungs and its concentration in blood were still reduced, while the transport and absorption of serotonin by the lungs, as well as its content in arterial blood, increased; this was attended by an increase in total pulmonary resistance and the development of moderate hypoxemia. Animals who died subsequently had a higher level of serotonin in arterial blood but a lower level of histamine. The role of the lungs in homeostasis of blood biogenic amines in the postresuscitation period is discussed.
Trubina
I E
IE
Il'icheva
R F
RF
Volkov
A V
AV
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D004285:Dogs; D008168:Lung / Q000378:metabolism*; D012151:Resuscitation
D001679:Biogenic Amines
Uchastie legkikh v pogloshchenii i vysvobozhdenii biogennykh aminov v postreanimatsionnom periode.