Streptococcal antigen-induced dislocation and dysplasia of the hip in newborn rats. Radiologic and histologic evaluation of a model of congenital dislocation of the hip.
Dislocation of the hip developed in 62% of newborn rats with streptococcal antigen-induced synovitis. Age at the time of the induction of synovitis is critical since dislocation is not observed in older rats. Synovitis with distention and laxity of the joint capsule is most likely responsible for the hip dislocation. Although congenital dislocation of the hip in children is not mediated by an inflammatory process, the current model of dislocation of the hip in rats is similar in being critically age-dependent, and associated with ligamentous laxity. Our model may be helpful in studying this important clinical entity.
Parker
M D
MD
Department of Radiology, University of North Carolina, School of Medicine, Chapel Hill 27514.
Clark
R L
RL
Cuttino
J T
JT
Anderle
S K
SK
Schwab
J H
JH
D000367:Age Factors; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage; D004195:Disease Models, Animal; D006617:Hip Dislocation / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D006618:Hip Dislocation, Congenital; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013291:Streptococcus / Q000276:immunology; D013585:Synovitis / Q000150:complications*
D000942:Antigens, Bacterial