[The disposition of bornaprine hydrochloride in the rat. 2. The metabolism of exo-epimers].
The biotransformation of an epimeric form of the anticholinergic drug exo-2-phenyl-bicyclo-[2.2.1.]-heptane-2-carboxylic acid (4'-diethylaminopropyl)ester hydrochloride (bornaprine hydrochloride, Sormodren) was investigated after oral application in male Wistar rats. Main metabolite of the exo-isomer in the feces was the hydroxylated and sulfate-conjugated product, substitution having occurred at C(5) of the bicyclic ring in exo-position. As further metabolites, the sulfate-conjugate in exo-position at C(6) and the N-desethyl derivatives of both were detectable.
Neidlein
R
R
Pharmazeutisch-chemisches Institut, Universität Heidelberg.
Pichler
B
B
Hege
G
G
Weymann
J
J
D000818:Animals; D000978:Antiparkinson Agents / Q000493:pharmacokinetics*; D001646:Bile / Q000032:analysis; D001711:Biotransformation; D001952:Bridged-Ring Compounds / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000032:analysis; D007536:Isomerism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000978:Antiparkinson Agents; D001952:Bridged-Ring Compounds; C006088:bornaprine
Zur Disposition von Bornaprin-hydrochlorid bei der Ratte. 2. Mitteilung: Untersuchungen zum Metabolismus des Exo-Epimeren.