[The clinical usefulness of serum CA72-4 analysis in patients with ovarian cancer].
Serum CA72-4 levels were measured by a radioimmunoassay using the murine monoclonal antibody B72.3 in gynecologic disease. The sensitivity and specificity was compared with those of CA125. If the upper limit of normal is set at 3.9U/ml of serum, all serum of normal healthy donors is negative, and in only 5 of 73 serum samples (6.8%) from patients with benign gynecologic disease is CA72-4 increased, whereas in 28 of 63 (44.4%) of ovarian cancer patients it is positive. The positivity of serum CA72-4 in ovarian cancer is as follows: 8.3% in stage I, 25.0% in stage II, 48.0% in stage III, and 85.7% in stage IV, respectively. Serum CA72-4 is increased in 39.1% of serous cystadenocarcinoma, 52.0% of mucinous cystadenocarcinoma, 44.4% of endometrioid carcinoma, and 33.3% of clear cell carcinoma. Consequently, the one positive finding is that the CA72-4 test appears to be more useful in mucinous tumors than is the CA125. The use of CA72-4 and CA125 in combination is useful in increasing sensitivity because of the poor reaction of CA125 in mucinous tumors.
Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine.
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Kobayashi
D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D003536:Cystadenocarcinoma / Q000175:diagnosis; D004715:Endometriosis / Q000175:diagnosis; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D011863:Radioimmunoassay; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis; D014594:Uterine Neoplasms / Q000175:diagnosis
D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor