Effects of the diterpene sclareol glycol on convulsive seizures.
The effects of the diterpene sclareol glycol (SG) of the labdane family on convulsive seizures induced by pentylenetetrazole (PTZ), picrotoxin and bicuculline in mice were studied. Sclareol glycol potentiated convulsive seizures induced by PTZ (60 and 80 mg/kg) and antagonized the anticonvulsant effect of diazepam. At low doses, SG gave a protective effect against convulsions induced by picrotoxin and bicuculline, and prolonged the latency to convulsions. At larger doses, SG increased the intensity of convulsive seizures. Forskolin, a diterpene of the same family, evoked a protective effect against convulsions induced by bicuculline and prolonged the latency.
Institute of Pharmacology and Pharmacy, Medical Academy, Sofia, Bulgaria.
J
J
Georgieva
D000818:Animals; D001640:Bicuculline; D005576:Colforsin / Q000494:pharmacology; D003292:Convulsants / Q000494:pharmacology*; D004224:Diterpenes / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D010852:Picrotoxin; D012640:Seizures / Q000139:chemically induced*
D001640:Bicuculline; D005576:Colforsin; D003292:Convulsants; D004224:Diterpenes; D010433:Pentylenetetrazole; D010852:Picrotoxin; C060464:sclareol glycol