The progress of oesophageal involvement in progressive systemic sclerosis during D-penicillamine treatment.
In 21 patients with initial signs of progressive systemic sclerosis, oesophageal motility was monitored manometrically from the start of D-penicillamine treatment and over a period of up to 5 years. Urinary excretion of the collagen-specific amino acids hydroxyproline and hydroxylysine, and of proline was used as a guideline for monitoring the bioavailability of D-penicillamine. D-penicillamine therapy was found to be unable to arrest the progress of oesophageal involvement. A downward trend over time--statistically significant at p = 0.03, p = 0.02, and p less than 0.005--was found for lower oesophageal sphincter pressure, peristaltic wave pressure in the distal third, and peristaltic wave pressure in the middle third of the oesophagus, respectively.
Department of Dermatology, Rigshospital, Copenhagen, Denmark.
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L
Hendel
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Stentoft
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S
Aggestrup
D004941:Esophagitis / Q000209:etiology; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology; D006801:Humans; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use*; D010528:Peristalsis; D011446:Prospective Studies; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*
D010396:Penicillamine