Imipramine prevents stress gastric glandular lesions in rats.
Intraperitoneal (i.p.) administration of imipramine dose-dependently inhibited gastric lesions induced by 3 h of cold restraint stress. The high dose of imipramine (5 mg/kg) almost completely abolished gastric lesion formation, and also suppressed acid secretion in rats with pyloric ligation. Intracisternal imipramine (1 microgram) was also protective. These findings suggest that tricyclic antidepressants may play an important role in preventing the deleterious effects of stress on the gut.
Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033.
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Hernandez
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Xue
D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D007099:Imipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010437:Peptic Ulcer / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological
D007099:Imipramine