Thin layer chromatographic detection of kryptofix 2.2.2 in the routine synthesis of [18F]2-fluoro-2-deoxy-D-glucose.
A simple procedure for the detection of 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo (8.8.8) hexacosane (Kryptofix 2.2.2) in the final solution of [18F]FDG prepared by the aminopolyether supported nucleophilic substitution of 1,3,4,6-tetra-O-acetyl 2-O-trifluoromethanesulfonyl-beta-D-mannopyranose (Hamacher et al., 1986) has been developed. Presence of Kryptofix 2.2.2 in the routine production of [18F]FDG was detected using methanol/ammonium hydroxide (9:1) solvent system. A method to remove Kryptofix from [18F]FDG solution has been suggested.
Research Department, North Shore University Hospital, Manhasset, NY 11030.
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Chaly
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Dahl
D001643:Bridged Bicyclo Compounds / Q000032:analysis*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000032:analysis*; D002614:Chelating Agents / Q000032:analysis*; D002855:Chromatography, Thin Layer; D003837:Deoxy Sugars / Q000138:chemical synthesis*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; D002614:Chelating Agents; D003837:Deoxy Sugars; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; C006071:cryptating agent 222; D003847:Deoxyglucose