[Assessment of the degree of carcinogenicity of small doses of nitrites].
Chronic experiments on CBA and C57B1 mice and acute experiments on CBA mice established: (a) carcinogenic effect of sodium nitrite given continuously with drinking water (0.1; 1.0 and 10.0 maximum allowable concentration) in combination with morpholine fed with bread, and (b) endogenous synthesis of nitrosomorpholine as a result of simultaneous intragastric administration of same doses of sodium nitrite and morpholine. Also, nitrosomorpholine and N-nitrosodimethylamine synthesis was observed in vitro following addition of low-dose sodium nitrite, morpholine and amidopyrine to human gastric juice. Carcinogenic hazard associated with low-dose nitrite consumption in humans is discussed.
Il'nitskiĭ
A P
AP
Iurchenko
V A
VA
Zhukova
G F
GF
Ermilov
V B
VB
D000632:Aminopyrine / Q000008:administration & dosage; D000818:Animals; D002273:Carcinogens / Q000096:biosynthesis; D004128:Dimethylnitrosamine / Q000096:biosynthesis; D005260:Female; D005502:Food; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009025:Morpholines / Q000008:administration & dosage; D009573:Nitrites / Q000633:toxicity*; D009602:Nitrosamines / Q000096:biosynthesis; D012977:Sodium Nitrite / Q000008:administration & dosage / Q000633:toxicity; D014881:Water Supply
D002273:Carcinogens; D009025:Morpholines; D009573:Nitrites; D009602:Nitrosamines; D000632:Aminopyrine; C037574:morpholine; D012977:Sodium Nitrite; D004128:Dimethylnitrosamine
Otsenka stepeni kantserogennoĭ opasnosti malykh doz nitritov.