Effects of guinea pig vasoactive intestinal peptide on the isolated perfused guinea pig heart.
The pharmacological effects of guinea pig vasoactive intestinal peptide (VIP) were studied in isolated perfused guinea pig hearts. Bolus injections of VIP produced a dose-dependent tachycardia that was not affected by atenolol. A decrease in amplitude of ventricular contractions occurred in response to all doses of VIP. This response was preceded by a small increase in amplitude in 3 of 6 hearts at the highest dose. VIP produced a decrease in perfusion pressure which was prominent after coronary tone was elevated with [Arg8]-vasopressin. The present findings support speculation that VIP may have a role in the regulation of heart rate and coronary blood flow.
Department of Pharmacology, Quillen-Dishner College of Medicine, East Tennessee State University, Johnson City 37614.
D B
DB
Hoover
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D001262:Atenolol / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010477:Perfusion; D011312:Pressure; D014660:Vasoactive Intestinal Peptide / Q000502:physiology*; D014664:Vasodilation
D001127:Arginine Vasopressin; D014660:Vasoactive Intestinal Peptide; D001262:Atenolol