Effect of NSAIDS on serum electrolytes and osmolality.
Rabbits and rats were injected two Nonsteroidal anti-inflammatory drugs (aspirin 300 mg/kg or indomethacin 3 mg/kg) intraperitoneally. One hour after injection blood was analyzed for serum electrolytes and osmolality. Administration of both aspirin and indomethacin in rabbits and rats caused increase in serum sodium, potassium, calcium, chloride, magnesium, phosphorus and osmolality. Results suggest the marked similarity in the action of aspirin and indomethacin on electrolytes and osmolality. It is concluded that the ingestion of aspirin and indomethacin can have a major effect on serum electrolytes and osmolality that may influence the interpretation of clinical data in patients taking these drugs.
Mahboob
T
T
Department of Biochemistry, University of Karachi, Pakistan.
Haleem
M A
MA
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D002712:Chlorides / Q000097:blood; D004573:Electrolytes / Q000097:blood*; D006400:Hematocrit; D007213:Indomethacin / Q000494:pharmacology*; D008274:Magnesium / Q000097:blood; D009994:Osmolar Concentration; D010710:Phosphates / Q000097:blood; D011188:Potassium / Q000097:blood; D011817:Rabbits; D051381:Rats; D012016:Reference Values; D012964:Sodium / Q000097:blood
D002712:Chlorides; D004573:Electrolytes; D010710:Phosphates; D012964:Sodium; D008274:Magnesium; D001241:Aspirin; D011188:Potassium; D002118:Calcium; D007213:Indomethacin