Morphometric analysis of nuclear/cytoplasmic ratios in normal and perineoplastic vulvar skin.
Analysis of vulvar skin adjacent to squamous carcinoma has demonstrated abnormal deoxyribonucleic acid (DNA) content in histologically unremarkable specimens. Analysis of DNA by microdensitometry is time-consuming. Morphometric analysis by point counting was used to compare the nuclear/cytoplasmic ratios of normal vulvar skin and skin adjacent to malignancy. This showed elevated ratios in the latter specimens although there was no linear relationship to increasing ploidy.
Regional Gynaecological Oncology Unit, Queen Elizabeth II Hospital, Gateshead, UK.
J C
JC
Dalrymple
A K
AK
Brough
J M
JM
Monaghan
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology*; D002648:Child; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D014846:Vulvar Neoplasms / Q000235:genetics* / Q000473:pathology
D004273:DNA, Neoplasm