Long-term survival of decentralized axons and incorporation of satellite cells in motor neurons of rock lobsters.
Previous electrophysiological experiments have shown that in the abdominal extensor muscles of rock lobsters, axons which were cut in surviving animals do not degenerate peripherally for several months, but conduct action potentials and release transmitter quanta on stimulation closely distal to the scar. Electron micrographs from the axon distal to the scar (in a reliably conducting region) show invasion of the axoplasmic space by nucleated cells, probably glia. After several months, the cell membranes of the invaders have vanished and apparently functional multiple nuclei remain. We suggest that decentralized axons may survive for months with the help of 'donated' nuclei.
Atwood
H L
HL
Otto Loewi Center for Cellular and Molecular Neurobiology, Hebrew University, Jerusalem, Israel.
Dudel
J
J
Feinstein
N
N
Parnas
I
I
D000200:Action Potentials; D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D002470:Cell Survival; D003714:Denervation; D008854:Microscopy, Electron; D009046:Motor Neurons / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D008121:Nephropidae / Q000033:anatomy & histology*; D009469:Neuromuscular Junction / Q000648:ultrastructure