[Characteristics of the metabolism and gonadal action in mice of tritium-labelled deoxycytidine].
The levels of 3H-deoxycytidine binding in mice and rats were shown to depend on the amount of the carrier and the routes of administration, and the dynamics of its retention, on the dose and schedule of its administration. As estimated by the criterion of the testis mass decrease the 3H-deoxycytidine dose of 37 kBq/g is equivalent to gamma-radiation dose of 0.06 Gy. The coefficient of 3H-deoxycytidine absorption from the digestive tract of mice and rats is 2-10 times as high as that of 3H-thymidine, while both compounds administered to rats transcutaneously have the same absorption coefficients amounting to 0.02.
Balonov
M I
MI
Zhesko
T V
TV
Chetchueva
M E
ME
D000818:Animals; D003841:Deoxycytidine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution; D014316:Tritium
D003841:Deoxycytidine; D014316:Tritium
Osobennosti metabolizma i deĭstviia na gonady myshi mechennogo tritie dezoksitsitidina.