Neutrophil function and humoral immunity in children with recurrent infections of the lower respiratory tract and chronic bronchial suppuration.
Neutrophil motility and superoxide anion production and serum immunoglobulin levels were assessed in 51 children with recurrent infections of the lower respiratory tract and chronic bronchial suppuration, not due to anatomic or functional cause. In 26 children (50.9%), a significant defect of the immunologic defenses, likely to be responsible for the disease, was observed. A precocious diagnosis and an adequate therapy could result, at least in some patients, in the prevention of progressive lung damage.
Pediatric Pneumology and Cystic Fibrosis Center, Ospedale Civile Maggiore, Verona, Italy.
G
G
Cazzola
E A
EA
Valletta
S
S
Ciaffoni
C
C
Roata
G
G
Mastella
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D001424:Bacterial Infections / Q000097:blood / Q000276:immunology*; D001987:Bronchiectasis / Q000097:blood / Q000276:immunology*; D001996:Bronchopneumonia / Q000097:blood / Q000276:immunology*; D002465:Cell Movement; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils / Q000276:immunology* / Q000473:pathology; D012008:Recurrence; D013492:Suppuration / Q000097:blood / Q000276:immunology
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E