Prostaglandin-induced hyperostosis. A case report.
The use of prostaglandin-E1 (PGE1) to maintain patency of the ductus arteriosus in infants with ductal-dependent congenital heart disease is now well established. A 2.5-month-old child with cyanotic heart disease who required long-term PGE1 infusions; developed widespread periosteal reactions during the course of therapy. Prostaglandin-induced subperiosteal hyperostosis should now be considered in the differential diagnosis of neonatal cortical proliferation.
Emory University School of Medicine, Atlanta, Georgia 30303.
D M
DM
Drvaric
W J
WJ
Parks
J B
JB
Wyly
K J
KJ
Dooley
W H
WH
Plauth
E W
EW
Schmitt
D000527:Alprostadil / Q000009:adverse effects* / Q000627:therapeutic use; D001847:Bone Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy*; D010522:Periostitis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography
D000527:Alprostadil