The effect of substituted aminoalkylaminoanthraquinones on eukaryotic cells.
Nine aminoalkylaminoanthraquinones (I-IX) were evaluated for their cytotoxic potency against normal and malignant mammalian cells. The 1.8-di-(aminopropylamino) derivative (VIII) exhibited significant activity against several tumor cell systems and had some selectivity. The toxicity of this compound was also tested in growing chick embryos.
Department of Pharmaceutical Chemistry, Hebrew University School of Pharmacy, Jerusalem, Israel.
J
J
Katzhendler
G
G
Bar-Ad
M
M
Haran
K F
KF
Gean
Z
Z
Tashma
I
I
Ringel
A
A
Ramu
U
U
Bachrach
D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D005347:Fibroblasts / Q000187:drug effects; D005910:Glioma / Q000473:pathology; D007941:Leukemia P388 / Q000473:pathology; D009447:Neuroblastoma / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000880:Anthraquinones; D000970:Antineoplastic Agents