[Clozapine-induced cholestatic jaundice: a case report].
We report on a patient who became jaundiced during treatment with clozapine (Leponex). Histologically, cholestatic hepatitis with single-cell necroses of hepatocytes and infiltration of the portal zones with eosinophilic granulocytes were found. The patient recovered after discontinuation of clozapine, and liver function tests returned to normal within 4 weeks. This adverse effect of clozapine suggests that this "atypical" tricyclic neuroleptic resembles the phenothiazines both with regard to therapeutic spectrum and side effects.
Medizinische Klinik, Stadtspital Triemli, Zürich.
G
G
Dorta
R
R
Siebenmann
P
P
Fröhli
P
P
Freytag
H R
HR
Koelz
D000368:Aged; D001321:Autistic Disorder / Q000188:drug therapy*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000473:pathology; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D003984:Dibenzazepines / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology
D003984:Dibenzazepines; D003024:Clozapine
Clozapin-induzierter cholestatischer Ikterus: ein Fallbericht.