[Intra-arterial chemotherapy with angiotensin II in metastatic carcinoma of the liver using implantable pump].
Nine patients with metastatic carcinoma involving the liver were treated by hepatic arterial chemotherapy with Angiotensin II (AGT II) using a subcutaneous implanted pump. There were two primary lesions in the breast, one in the stomach, three in the colon and three in the rectum. Every patient received intra-arterial bolus injection of 5-FU and Adriamycin with 3 mcg of AGT II weekly at our outclinic. Of 7 evaluable patients, 6 responded clinically with PR (response rate, 85.7%). No adverse effects were noted in relation to AGT II. AGT II combined with chemotherapy is therefore a safe and effective method for even outpatients with liver metastases.
Second Dept. of Surgery, Saitama Medical Center.
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S
Takagi
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Murata
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M
Wada
M
M
Kobayashi
M
M
Seki
D000328:Adult; D000368:Aged; D000804:Angiotensin II / Q000008:administration & dosage* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007260:Infusion Pumps; D007261:Infusions, Intra-Arterial / Q000379:methods; D008113:Liver Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012074:Remission Induction
D014408:Biomarkers, Tumor; D000804:Angiotensin II; D004317:Doxorubicin; D005472:Fluorouracil