Elevated serum levels of soluble interleukin-2 receptors in HIV infection: no correlation with activated T cells.
Serum levels of soluble interleukin-2 receptors (sIL-2R) were measured in 105 HIV-seropositive individuals simultaneously with T cell subsets and activated T cells (CD3+ and HLA-DR+). Significantly elevated levels of serum sIL-2R were found (564 +/- 259 U/ml versus 258 +/- 87 U/ml in 70 controls, p less than 0.001), as well as increased numbers of activated T cells (mean numbers, 579/microliters in the patients versus 113/microliters in 26 controls, p less than 0.0001). Correlation analysis did not disclose any significant association between elevated sIL-2R and increased activated T cells, nor with decreased CD4+ lymphocytes. These data suggest that sIL-2R in HIV infection do not emanate from activated T cells and are not linked to CD4+ cell loss.
Service d'Onco-Hématologie, Hôpital de Hautepierre, Strasbourg, France.
J M
JM
Lang
G
G
Coumaros
S
S
Levy
A
A
Falkenrodt
M
M
Steckmeyer
M
M
Partisani
A
A
Aleksijevic
L
L
Lehr
C
C
Koehl
D000293:Adolescent; D000328:Adult; D005260:Female; D006679:HIV Seropositivity / Q000097:blood* / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D012995:Solubility; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
D015375:Receptors, Interleukin-2