[Evaluation of gallbladder emptying in patients with chronic liver disease by 99mTc-EHIDA hepatobiliary scintigraphy].
Gallbladder emptying after intramuscular injection of cerulein was investigated by 99mTc-EHIDA hepatobiliary scintigraphy in 23 patients with biliary disease, 55 patients with chronic liver disease, and 21 normal controls. The mean gallbladder ejection fraction in patients with gallstones and liver cirrhosis was significantly reduced compared with normal controls. (gallstones: 56.3 +/- 21.3%, LC with gallstones: 50.8 +/- 29.6%, LC without gallstones: 55.9 +/- 26.7%, vs. normal controls: 74.4 +/- 12.9%, p less than 0.01). The mechanism for sluggish gallbladder emptying in liver cirrhosis is unknown, however impaired emptying with bile stasis provides a potential pathophysiologic basis for the high frequency of pigment stones.
Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital, Japan.
N
N
Kurihara
H
H
Ide
T
T
Omata
S
S
Yonamine
Y
Y
Mashima
M
M
Tanno
K
K
Chiba
H
H
Yamada
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002108:Ceruletide; D002769:Cholelithiasis / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D007098:Imino Acids; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D011877:Radionuclide Imaging; D013667:Technetium; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid
D007098:Imino Acids; D009942:Organometallic Compounds; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid; D013667:Technetium; D002108:Ceruletide