Protective effect of idebenone against hypoxia in mice.
The effects of idebenone on survival time of mice subjected to hypoxia induced by N2 and CO2 inhalation and KCN injection were studied. Idebenone (10, 20, 50 and 100 mg/kg, i.p.) prolonged the survival time of mice exposed to a hypoxic condition (98% N2, 2% O2) in a dose-dependent manner: significant prolongations were observed at doses higher than 20 mg/kg. The drug also exerted a similar elongation effect at the same doses under conditions of 100% CO2 gas inhalation and KCN injection (3 mg/kg, i.v.). The results suggest that idebenone protects against hypoxia by improving cerebral energy metabolism.
Kiyota
Y
Y
Central Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan.
Miyamoto
M
M
Nagaoka
A
A
D000818:Animals; D016227:Benzoquinones; D002540:Cerebral Cortex / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D000860:Hypoxia / Q000188:drug therapy*; D051379:Mice; D008813:Mice, Inbred ICR; D011809:Quinones / Q000494:pharmacology*; D014451:Ubiquinone / Q000031:analogs & derivatives
D016227:Benzoquinones; D011809:Quinones; D014451:Ubiquinone; C036619:idebenone