[Inhibitory effects of new-breviscapine on thrombosis in vivo].
New-Breviscapine is an anti-platelet compound with some kinds of salts extracted from a Chinese herb Erigeron breviscapus. In aortic thrombus formation in rabbits, the platelet 5-HT release reaction and platelet destruction could be reduced by the compound, meanwhile aortic thrombosis was inhibited with a clear correlation between drug dosage and its efficacy. It was shown that new-breviscapine could inhibit the production of TXB2 and 6-keto-PGF1 alpha by platelets and endothelial cells respectively. The data suggest that new-breviscapine has a significant inhibitory effect on thrombus formation in vivo through suppression of platelet functions.
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D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000818:Animals; D000925:Anticoagulants; D001792:Blood Platelets / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005419:Flavonoids; D008297:Male; D011817:Rabbits; D013927:Thrombosis / Q000097:blood / Q000517:prevention & control*; D013929:Thromboxane B2 / Q000097:blood*
D000925:Anticoagulants; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C061097:breviscapine; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha