Effect of diet on [lactate]/[pyruvate] ratios during alcohol metabolism in man.
Ten subjects received alcohol by intravenous infusion on two occasions, after five-day periods on high- or low-carbohydrate diets. Blood [lactate]/[pyruvate] ratios were significantly higher during fasting alcohol metabolism after the low-carbohydrate, high-fat diet. The carbohydrate/fat balance in the diet may affect cytoplasmic-mitochondrial NADH transfer. Dietary composition may modify the metabolic changes caused by alcohol.
Department of Pharmacology, University of Sydney, NSW, Australia.
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D
Mascord
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J
Rogers
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J
Smith
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GA
Starmer
J B
JB
Whitfield
D000328:Adult; D000435:Alcoholic Intoxication / Q000097:blood; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D000431:Ethanol / Q000493:pharmacokinetics*; D006801:Humans; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011773:Pyruvates / Q000097:blood*; D019289:Pyruvic Acid
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D000431:Ethanol; D019289:Pyruvic Acid