Sulfadoxine specific lymphocyte transformation in a patient with eosinophilic pneumonia induced by sulfadoxine-pyrimethamine (Fansidar).
A patient developed eosinophilic peripheral pulmonary infiltrates while receiving malaria prophylaxis with sulfadoxine-pyrimethamine (Fansidar). Withdrawal of Fansidar and treatment with corticosteroids led to rapid recovery. No exacerbation occurred after cessation of corticosteroids. Lymphocyte transformation testing gave a positive result in the presence of sulfadoxine but not pyrimethamine. It is concluded that drug hypersensitivity to sulfadoxine was the cause of the eosinophilic pneumonia in this patient.
Daniel
P T
PT
Department II of Internal Medicine, University of Tübingen, Federal Republic of Germany.
Holzschuh
J
J
Berg
P A
PA
D000328:Adult; D000962:Antimalarials / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008288:Malaria / Q000517:prevention & control; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000276:immunology; D011739:Pyrimethamine / Q000009:adverse effects*; D013413:Sulfadoxine / Q000009:adverse effects*; D013424:Sulfanilamides / Q000009:adverse effects*
D000962:Antimalarials; D004338:Drug Combinations; D013424:Sulfanilamides; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011739:Pyrimethamine