[Genetic epidemiology of schizophrenia in the population of Tomsk Oblast. Dependence of parameters of the occurrence of schizophrenia among relatives on the method of proband sample formation].
The program of genetic-epidemiological study of schizophrenia in five districts of the Tomsk region is presented. According to standardized methods, 610 diagnosed patients (epidemiological register) were examined, 74.1% of them being at random registered as probands (452 families of the epidemiological sample). 229 probands of non-epidemiological sample were registered in psychiatric hospitals. Schizophrenia occurrence parameters among first-degree relatives of probands of the non-epidemiological sample were regularly overestimated, as compared to the epidemiological sample. The methodical sources of contradictions in clinico-genealogical studies are discussed; the conclusion about representativeness+ of the probands' epidemiological sample is made.
M S
MS
Ritsner
S I
SI
Karas'
O L
OL
Sherina
I G
IG
Boiarintseva
E V
EV
Gutkevich
D006801:Humans; D012494:Sampling Studies; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D012800:Siberia
Geneticheskaia épidemiologiia shizofrenii v populiatsii Tomskoĭ oblasti. Zavisimost' pokazateleĭ rasprostranennosti shizofrenii sredi rodstvennikov ot sposoba formirovaniia vyborki probandov.