Indices of calcium metabolism in women with hip fractures.
We have assessed indices of calcium metabolism in 41 women with hip fractures and compared them with two elderly control groups. The women with hip fractures had lower serum concentrations of albumin, 25-hydroxyvitamin D and osteocalcin than the controls. Serum concentrations of calcium, alkaline phosphatase and parathyroid hormone, as well as urinary hydroxyproline/creatinine ratios were similar in the three groups of women. The small reduction in serum osteocalcin concentration in fracture patients is consistent with the hypothesis that reduced osteoblast function may contribute to the osteoporosis which results in hip fracture.
MRC Environmental Epidemiology Unit, Southampton General Hospital, England.
C
C
Cooper
M
M
Mclaren
P J
PJ
Wood
L
L
Coulton
J A
JA
Kanis
D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism; D002112:Calcifediol / Q000097:blood; D002118:Calcium / Q000097:blood*; D002135:Calcium-Binding Proteins / Q000097:blood; D005260:Female; D006620:Hip Fractures / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D015675:Osteocalcin; D010281:Parathyroid Hormone / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism
D002135:Calcium-Binding Proteins; D010281:Parathyroid Hormone; D012709:Serum Albumin; D015675:Osteocalcin; D000469:Alkaline Phosphatase; D002112:Calcifediol; D002118:Calcium