Morphometric evaluation of rhesus articular cartilage: correlation of hexosamine and 35SO4 = incorporation.
Morphometric evaluation of 20 rhesus articular cartilage samples were correlated with hexosamine and an 18-hour incorporation of 35SO4- as a measure of proteoglycan production on samples from the same joint. Reduced chondrocyte cellularity was the basis of the reduced maintenance of the matrix by the chondrocyte. In the more cellular cartilage, the matrix/lacunae area ratio was less than 25, and the less cellular group had a ratio of greater than 40. An inverse correlation existed between morphometric cartilage matrix/lacunar area ratio and hexosamine content. A significant difference of 35SO4 incorporation was not seen between the three morphometric grades. Morphometric assessment reduces the subjectivity of articular cartilage evaluation.
Roberts
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ED
Department of Veterinary Pathology, Louisiana State University School of Veterinary Medicine, Baton Rouge.
Zeman
D H
DH
Miwa
T
T
Shoje
H
H
D000818:Animals; D002358:Cartilage, Articular / Q000032:analysis / Q000166:cytology* / Q000378:metabolism; D006595:Hexosamines / Q000032:analysis*; D007719:Knee Joint; D008253:Macaca mulatta; D011509:Proteoglycans / Q000032:analysis* / Q000096:biosynthesis; D013431:Sulfates / Q000378:metabolism; D013997:Time Factors
D006595:Hexosamines; D011509:Proteoglycans; D013431:Sulfates