Daily metabolism and hepatic balance studies of plasma cortisol and aldosterone in the preruminant calf.
Intestinal and hepatic catabolism of cortisol and aldosterone were studied in the calf using blood samples from the mesenteric artery and portal and hepatic veins collected over 24 h, the hepatic blood flow being continuously recorded during this period. The total hepatic blood flow remained broadly constant over the 24 h, although meals were followed by decreasing flow in the portal vein and by increasing flow in the hepatic artery. The intestinal tract catabolizes cortisol as intensively as the liver (both 13% of cortisol reaching the organ). The part played by the gut and the liver in the catabolism of aldosterone were also equivalent (both 30% of aldosterone reaching the organ). This 24-h study demonstrated that a constant ratio existed between secretion and catabolism of cortisol while the hepatic balance of aldosterone seemed to be modified during the night.
Laboratoire de Physiologie Animale et UA CNRS 1123, Université Blaise Pascal-Clermont-Ferrand II, Aubière, France.
M
M
Gardy-Godillot
M
M
Dalle
D
D
Bauchart
D
D
Durand
P
P
Delost
D000450:Aldosterone / Q000097:blood*; D000818:Animals; D002417:Cattle; D002940:Circadian Rhythm; D003348:Cortisone / Q000097:blood*; D006503:Hepatic Veins; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D008638:Mesenteric Arteries; D011169:Portal Vein
D000450:Aldosterone; D003348:Cortisone