Antibodies to glutaraldehyde-polymerized human albumin (anti-pHSA) in viral hepatitis.
The antibody to polymerized human albumin (anti-pHSA) was studied in normal subjects and in the course of infection from hepatitis A virus, hepatitis B virus, and hepatitis non-A, non-B virus. Results show that anti-pHSA antibody was never found in normal subjects, but it appeared during virus liver pathologies. The behavior of anti-pHSA differs in acute type A hepatitis that does not change to chronic form and in those forms which tend to become chronic (B and nonA, nonB). In the type-A infection anti-pHSA disappears after the acute phase; in the other two forms it persists all along as the infection develops. Specifically in non-A, non-B infection only the IgM type anti-pHSA is produced.
Sansonno
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DE
Laboratory of Liver Immunopathology, Istituto di Ricovero e Cura a Carattere Scientifico, Castellana Grotte Bari, Italy.
Detomaso
P
P
Leone
G
G
Bufano
G
G
Rizzi
R
R
Manghisi
O G
OG
D000208:Acute Disease; D000906:Antibodies / Q000032:analysis*; D002908:Chronic Disease; D005260:Female; D006525:Hepatitis, Viral, Human / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D012709:Serum Albumin / Q000276:immunology*; D000075462:Serum Albumin, Human
D000906:Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012709:Serum Albumin; C032137:polyalbumin; D000075462:Serum Albumin, Human