Effects of vanadyl sulphate on ornithine decarboxylase and progesterone levels in the ovary of rat.
The effects of vanadyl sulphate in vitro on the levels of ODC activity and progesterone synthesis in ovaries were studied. The levels of ODC in the ovaries were stimulated with high concentration of vanadyl sulphate and at low concentrations there was no change in the levels of ODC activity. On the contrary progesterone levels were stimulated with low concentrations of vanadyl sulphate and were inhibited at higher concentrations. Vanadyl sulphate showed additional stimulation of ODC activity, when it was added with hCG and caused inhibition of hCG induced progesterone biosynthesis. These results show that the effects of vanadyl sulphate on ODC and progesterone are different.
Reddy
R L
RL
School of Life Sciences, University of Hyderabad, India.
Reddy
B V
BV
Reddy
P R
PR
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D010053:Ovary / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D011374:Progesterone / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D014639:Vanadium / Q000494:pharmacology*; D017968:Vanadium Compounds
D006063:Chorionic Gonadotropin; D017968:Vanadium Compounds; D014639:Vanadium; D011374:Progesterone; C034028:vanadyl sulfate; D009955:Ornithine Decarboxylase