The arbors of axons terminating in middle cortical layers of somatosensory area 3b in owl monkeys.
The arbors of single axons terminating predominantly in layer IV of the representation of the hand in area 3b of owl monkeys were reconstructed from serial brain sections after axons beneath the cortex were severed and horseradish peroxidase was injected into the white matter. In addition to dense terminations in layer IV, these labeled axons generally had branches extending into deeper layer III, and a few had very sparse terminations in layer VI. Terminal arbors ranged from 100 to 900 microns in diameter, and fine branches with synaptic boutons were unevenly distributed, typically grouped in a large central cluster and one or more smaller side clusters. The results are consistent with three broad conclusions: (1) Since the arbors are large relative to the details of the somatotopic map in area 3b, all regions within a single arbor may not be equally effective in activating cortical cells. (2) Spatially separate branches of single axons may relate to spatially separate modules of neurons of the same class in a manner that allows them to receive the same inputs. (3) Many of the somatotopic changes that have been reported in the hand representation as a result of nerve manipulations in adults could result from alterations in synaptic effectiveness within the arbors of single axons.
Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240.
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Garraghty
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Pons
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Kaas
D000344:Afferent Pathways / Q000033:anatomy & histology; D000818:Animals; D001029:Aotus trivirgatus / Q000033:anatomy & histology*; D001369:Axons / Q000648:ultrastructure*; D001931:Brain Mapping; D002427:Cebidae / Q000033:anatomy & histology*; D003712:Dendrites / Q000648:ultrastructure; D006225:Hand / Q000294:innervation*; D013003:Somatosensory Cortex / Q000033:anatomy & histology*; D013569:Synapses / Q000648:ultrastructure; D013787:Thalamic Nuclei / Q000033:anatomy & histology*