The influence of a non-ionic surfactant on rectal absorption of virus particles.
A bacterial virus, suspended in three different vehicles, was introduced into the rectum of rabbits. The virus was detected in the circulating blood as early as 10 min after the administration. The quantity of virus found in blood and the duration of its presence, were enhanced when a non-ionic surfactant was used as vehicle of the virus.
Sechter
I
I
Central Laboratory, Ministry of Health, Jerusalem, Israel.
Touitou
E
E
Donbrow
M
M
D000818:Animals; D000838:Anions / Q000494:pharmacology; D001435:Bacteriophages / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D007408:Intestinal Absorption / Q000187:drug effects*; D011817:Rabbits; D012007:Rectum / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology*; D013501:Surface-Active Agents / Q000494:pharmacology*
D000838:Anions; D013501:Surface-Active Agents