Prevention of urate nephropathy in the tumour lysis syndrome.
Patients with acute lymphoblastic leukaemia and a high tumour burden are at risk of developing acute renal failure when given chemotherapy. Rapid cell lysis releases a high urate load which may result in an obstructive urate nephropathy. This complication should be prevented by establishing an alkaline diuresis before initiating steroid or other chemotherapy.
O'Connor
N T
NT
Department of Haematology, Royal Free Hospital, London.
Prentice
H G
HG
Hoffbrand
A V
AV
D000293:Adolescent; D000493:Allopurinol / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003630:Daunorubicin / Q000008:administration & dosage / Q000009:adverse effects; D004231:Diuresis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007674:Kidney Diseases / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D015275:Tumor Lysis Syndrome / Q000150:complications*; D014527:Uric Acid / Q000378:metabolism*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
D014527:Uric Acid; D014750:Vincristine; D000493:Allopurinol; D011239:Prednisolone; D003630:Daunorubicin