Pupil size after extracapsular cataract extraction and posterior chamber lens implantation: a prospective randomized trial of epinephrine and acetylcholine.
The effects of using epinephrine in the irrigating fluid and intracameral acetylcholine were studied by measuring changes in pupil size in the 48 hours following extracapsular cataract extraction and intraocular lens implantation in 39 eyes. Epinephrine reduced peroperative pupil constriction, but its effect was insignificant thereafter. The pupil constriction following acetylcholine was maximal at 2 hours and was still significant at 4 hours, but pupils redilated by 6 hours. Neither drug had any effect after this time. The edge of most lens implants was visible at 6 hours, after which pupils steadily constricted.
Department of Ophthalmology, West Norwich Hospital, England.
A
A
Elliott
C
C
Carter
D000109:Acetylcholine / Q000494:pharmacology*; D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology*; D006801:Humans; D007910:Lenses, Intraocular; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D011680:Pupil / Q000187:drug effects / Q000473:pathology*; D011897:Random Allocation; D013997:Time Factors
D000109:Acetylcholine; D004837:Epinephrine