Elevated plasma levels of haptoglobin in Duchenne muscular dystrophy:electrophoretic variants in patients with a severe form of the disease.
Analysis of plasma proteins of Duchenne muscular dystrophy (DMD) patients and normal age-matched boys using two dimensional gel electrophoresis and densitometry indicated a three-fold increase in the average haptoglobin level in DMD plasma. Two electrophoretic variants of haptoglobin in which the alpha 2 chain had more basic or more acidic spots were found in DMD patients with a rapidly progressing form of the disease. The basic variant was present in relatively low amount. Possible reasons for the elevated haptoglobin levels are discussed.
Department of Genetics, University of Edinburgh, Scotland.
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John
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Purdom
D002675:Child, Preschool; D003720:Densitometry; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D014644:Genetic Variation; D006242:Haptoglobins / Q000235:genetics / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D009136:Muscular Dystrophies / Q000097:blood*; D010449:Peptide Mapping
D006242:Haptoglobins; D006454:Hemoglobins; C035492:haptoglobin-hemoglobin complex