The effect of gadolinium DTPA on tissue water compartments in slow- and fast-twitch rabbit muscles.
Proton T2 relaxation and its biexponential components have been determined in rabbit skeletal muscle in the presence and absence of GdDTPA. The effect of GdDTPA, which distributes only in the extracellular space, was greatest in the longer-relaxing T2 component (T22). A 27% reduction in T22 was measured for slow-twitch (red) muscle and 17% for fast-twitch (white) muscle, consistent with the larger extracellular space of the former. Magnetic resonance images demonstrated apparent contrast between red and white rabbit muscles. This contrast was instantaneously enhanced by administration of GdDTPA and returned to near normal levels after approximately 30 min. These functional changes in tissue contrast are consistent with differences in blood perfusion and biological water compartmentation between fast- and slow-twitch skeletal muscles.
Department of Radiology, Harvard Medical School, Boston, Massachusetts 02115.
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Adzamli
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Jolesz
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Bleier
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Mulkern
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Sandor
D000818:Animals; D003287:Contrast Media; D005110:Extracellular Space / Q000187:drug effects* / Q000378:metabolism; D005682:Gadolinium / Q000494:pharmacology*; D019786:Gadolinium DTPA; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D009942:Organometallic Compounds / Q000494:pharmacology*; D004369:Pentetic Acid / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA