TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding.
The neuroblastoma cell line SH-SY5Y was cultured in the presence of TPA for three days. Increased neurite formation was noted as early as 24 hours after TPA was added. These changes were associated with an increase in IGF-I receptor binding as well as increased mRNA for the IGF-I receptor.
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Section of Molecular and Cellular Physiology, NIDDK, Bethesda, MD 20892.
Shen-Orr
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Roberts
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LeRoith
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D001667:Binding, Competitive; D002454:Cell Differentiation / Q000187:drug effects; D003712:Dendrites / Q000187:drug effects / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism*; D009447:Neuroblastoma; D012333:RNA, Messenger / Q000378:metabolism*; D013002:Somatomedins / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism
D012333:RNA, Messenger; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D013755:Tetradecanoylphorbol Acetate