Entorhinal fibers form synaptic contacts on parvalbumin-immunoreactive neurons in the rat fascia dentata.
The entorhinal cortex gives rise to a dense projection to the outer two-thirds of the dentate molecular layer. The main target neurons are the granule cells. This study demonstrates that entorhinal fibers labeled by anterograde degeneration also terminate on parvalbumin-containing non-granule cells in the rat fascia dentata. Since the calcium-binding protein parvalbumin was recently found coexistent with gamma-aminobutyric acid in inhibitory hippocampal neurons, the described connection provides evidence for a role of entorhinal fibers in feed-forward inhibition of the granule cells.
Institute of Anatomy, Johann Wolfgang Goethe University, Frankfurt am Main, F.R.G.
F
F
Zipp
R
R
Nitsch
E
E
Soriano
M
M
Frotscher
D000818:Animals; D006624:Hippocampus / Q000378:metabolism / Q000648:ultrastructure*; D007150:Immunohistochemistry; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism*; D010320:Parvalbumins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000378:metabolism / Q000648:ultrastructure*
D009124:Muscle Proteins; D010320:Parvalbumins