Changes in the activity of oxygen-dependent metabolism in polymorphonuclear leukocytes and macrophages from a primary focus during experimental Y. pestis infection in the mouse.
The activity of oxygen-dependent metabolism (OM) was investigated in phagocytosing cells from a primary focus in plague infection using a mouse model. Experimental animals were given various i.p. doses of a virulent culture of Y. pestis. Changes in the OM of neutrophils and macrophages derived from peritoneal exudate after Y. pestis administration were phased and identical to non-specific post-aggression fluctuating reaction (PFR) comprising: 1. immediate depression phase, 2. overexertion phase and 3. exhaustion phase.
Isin
Z M
ZM
Central Asia Anti-Plague Research Institute, Alma-Ata, USSR.
D000818:Animals; D001202:Ascitic Fluid / Q000473:pathology; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000378:metabolism*; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D010930:Plague / Q000378:metabolism*
D009580:Nitroblue Tetrazolium; D010100:Oxygen