[Intra aqueous humor penetration of ciprofloxacin in humans].
Authors have studied the penetration of ciprofloxacin in the aqueous humor of 30 patients (30 eyes). The concentration in the anterior chamber was on average 0.73 mg/l (33% of serum level), from 1.30 hours after a single oral dose (1000 mg) till the 5th hour after this dose. The samples were assessed by a microbiological method. These results are over the minimal inhibitory concentration for many bacterial agents found in endophthalmitis. So this antibiotic may be proposed in the treatment of endophthalmitis, with further investigations assessing the safety of this procedure.
Service d'Ophtalmologie, CHU Jean-Minjoz, Centre Hospitalier Régional et Universitaire, Besançon, France.
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A
Bron
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Talon
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Cellier
J M
JM
Estavoyer
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Delbosc
J
J
Royer
D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000032:analysis* / Q000378:metabolism; D001424:Bacterial Infections / Q000188:drug therapy; D002386:Cataract / Q000188:drug therapy; D002387:Cataract Extraction; D002939:Ciprofloxacin / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005128:Eye Diseases / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication
D002939:Ciprofloxacin
La pénétration intra-camérulaire de la ciprofloxacine chez l'homme.