Peptic (contact ulcer) granuloma of the larynx.
Review of published work and analysis of clinical data and pathology of four biopsy specimens from two patients with laryngeal contact granuloma showed that its peptic origin was derived from a gastro-oesophago-laryngeal reflux. It is proposed that the term "peptic granuloma" should be given to this phenomenon. This term is given further support on account of the spectacular recovery of the laryngeal lesion following antacid and antireflux treatment, rather than the traditional method of using vocal rest and speech therapy, assumed to be the best way of treating a result of mechanical irritation, the previously accepted cause of laryngeal contact granuloma.
Department of Pathology, University Medical School of Debrecen, Hungary.
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D003937:Diagnosis, Differential; D005750:Gastric Juice / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000473:pathology; D006102:Granuloma, Laryngeal / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007818:Laryngeal Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications* / Q000473:pathology