Simple aliphatic diamines: acute neurotoxicity.
The acute neurotoxicity of a homologous series of diamines (ethylenediamine to 1,6-diaminohexane) was tested by injection into the lateral ventricle of conscious rats, documented as changes in behavior and electroencephalogram (EEG). Three distinct response patterns were seen ranging from prostration and EEG depression, to EEG seizures and convulsions, to a mixture of the patterns. All compounds were acutely lethal after micromole doses.
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GM
Veterinary Physiology, Louisiana State University School of Veterinary Medicine, Baton Rouge 80803-8420.
Flory
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W
D000818:Animals; D003959:Diamines / Q000633:toxicity*; D004569:Electroencephalography; D005971:Glutamates / Q000633:toxicity; D009422:Nervous System Diseases / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000633:toxicity
D003959:Diamines; D005971:Glutamates; D005680:gamma-Aminobutyric Acid