Chronic non-neurological toxicity from volatile substance abuse.
1. Most of the evidence for chronic non-neurological toxicity from volatile substance abuse is derived from case reports. 2. Factors important in assessing these reports are the marked variations in exposure conditions and in the composition of the products abused. 3. In a young and otherwise healthy population, any chronic organ toxicity arising from VSA has to be gross in order to become clinically apparent. This may partially explain the relatively low incidence of reporting. 4. Toluene and the chlorinated hydrocarbons 1,1,1-trichloroethane and trichloroethylene can cause permanent damage to the kidney, liver, heart and lung, in certain volatile substance abusers.
Department of Anaesthetics, Kings College Hospital, Denmark Hill, London, UK.
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Marjot
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McLeod
D000141:Acidosis, Renal Tubular / Q000139:chemically induced; D003645:Death, Sudden / Q000209:etiology; D004781:Environmental Exposure; D005921:Glomerulonephritis / Q000139:chemically induced; D006321:Heart / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008452:Maximum Allowable Concentration; D012997:Solvents / Q000633:toxicity*; D019966:Substance-Related Disorders / Q000473:pathology*; D014050:Toluene / Q000633:toxicity; D014240:Trichloroethanes / Q000633:toxicity; D014241:Trichloroethylene / Q000633:toxicity
D012997:Solvents; D014240:Trichloroethanes; C024566:1,1,1-trichloroethane; D014241:Trichloroethylene; D014050:Toluene