Mercury-selenium interaction: distribution and excretion of 203Hg2+ in rats after simultaneous administration of selenite or selenate.
In female rats intravenously injected with 203HgCl2 (0.6 mg Hg2+ per kg body wt.) the effect of intraperitoneal administration of selenite or selenate (0.525 mg Se per kg body wt.) on distribution and excretion of 203Hg was studied. The content of 203Hg was lower in kidney and higher in liver and blood in the groups treated with selenate or selenite when compared with rats which received only mercury. The brain content of 203Hg was significantly increased in rats injected with selenite. Both selenium compounds injected immediately after mercury significantly decreased urinary as well as biliary excretion of 203Hg. A transient increase in the rate of biliary excretion of 203Hg during the first 2 h after administration was observed in rats treated with selenate. This finding seems to support the idea that the reduction of selenate to selenite in the body is not rapid but takes at least several hours.
Institute of Hygiene and Epidemiology, Prague, Czechoslovakia.
M
M
Cikrt
V
V
Bencko
D000818:Animals; D001646:Bile / Q000032:analysis; D001659:Biliary Tract / Q000032:analysis; D001923:Brain Chemistry; D004347:Drug Interactions; D005243:Feces / Q000032:analysis; D005260:Female; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008627:Mercuric Chloride / Q000032:analysis / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D064586:Selenic Acid; D020887:Selenious Acid; D012643:Selenium / Q000008:administration & dosage*; D018036:Selenium Compounds
D018036:Selenium Compounds; D008627:Mercuric Chloride; D020887:Selenious Acid; D012643:Selenium; D064586:Selenic Acid