Intravenous fat emulsion (intralipid) delays gastric emptying, but does not cause gastroesophageal reflux in healthy volunteers.
The impact of overnight intravenous lipid emulsion (ILE) infusion on upper gastrointestinal tract physiology was assessed in 10 healthy volunteers. No changes in lower esophageal sphincter pressure (before infusion: 28 +/- 4 mm Hg; after infusion 20.5 +/- 3; p:NS), plasma concentrations of gastrointestinal hormones (gastrin: preprandial before/after lipids: 14 +/- 2.1/13 +/- 1.4 pM; postprandial before/after lipids: 28 +/- 2.7/30 +/- 3.4 pM, CCK: preprandial before/after lipids: 69 +/- 10/64 +/- 10 pM; postprandial before/after lipids: 96 +/- 11/95 +/- 12 pM; neurotensin: levels less than 6 pM in all samples; somatostatin levels undetectable in all samples) nor on pathologic gastroesophageal reflux episodes (% of time of pH less than 4, before/after lipids: 0.6 +/- 0.4/0.15 +/- 0.09), were found (p = NS). In contrast, technetium gastric emptying studies showed a significant delay when comparing pre- and post-lipid infusion values (37 +/- 4/54 +/- 4%) (p greater than 0.005). The mechanism of this effect remains unexplained.
Department of Pediatrics, University of California, Los Angeles 90024.
P R
PR
Casaubon
K A
KA
Dahlstrom
J
J
Vargas
R
R
Hawkins
M
M
Mogard
M E
ME
Ament
D000328:Adult; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D005746:Gastric Emptying; D005764:Gastroesophageal Reflux / Q000209:etiology*; D005768:Gastrointestinal Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D009325:Nausea; D012527:Satiation
D005217:Fat Emulsions, Intravenous; D005768:Gastrointestinal Hormones