[An immunohistochemical study on pre-S proteins of hepatitis B virus].
An indirect immunohistochemical technique was established to detect pre-S1 and pre-S2 proteins in liver with monoclonal antibodies, and altogether 80 samples of liver were studied. Under light microscope, pre-S1 and pre-S2 were known to be expressed in a similar way and might be divided into three patterns: diffusion type, inclusion type and membrane type. Membranous type expression of both pre-S1 and pre-S2 was associated with activity of the liver diseases and liver cell necrosis. Pre-S1 and Pre-S2 were also expressed in several samples of hepatocellular carcinoma.
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D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006521:Hepatitis, Chronic / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism*; D011498:Protein Precursors / Q000032:analysis*; D014759:Viral Envelope Proteins / Q000032:analysis*
D006514:Hepatitis B Surface Antigens; D011498:Protein Precursors; D014759:Viral Envelope Proteins; C050806:presurface protein 1, hepatitis B surface antigen; C050807:presurface protein 2, hepatitis B surface antigen