The effect of calcium entry blocker S-emopamil on cerebrocortical metabolism and blood flow changes evoked by graded hypotension.
Our studies demonstrate that in the explanation of the protective effect of the calcium antagonist (S)-emopamil the possibility of beneficial metabolic causes (lower O2 consumption) must also be considered beside of blood flow increasing effects. It is suggested that (S)-emopamil may be a useful drug for the treatment of cerebro-ischemic disorders.
Kovách
A G
AG
Experimental Research Department, Semmelweis Medical University, Budapest, Hungary.
Nguyen
L T
LT
Pék
L
L
Dezsi
L
L
Lohinai
Z S
ZS
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002415:Cats; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D007022:Hypotension / Q000503:physiopathology*; D008297:Male; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D012016:Reference Values; D012039:Regional Blood Flow / Q000187:drug effects; D013050:Spectrometry, Fluorescence / Q000379:methods; D014700:Verapamil / Q000031:analogs & derivatives* / Q000494:pharmacology
D002121:Calcium Channel Blockers; D009243:NAD; D014700:Verapamil; C052752:emopamil