Midazolam acts synergistically with methohexitone for induction of anaesthesia.
The induction dose-response of midazolam was compared with the dose-response of its combination with methohexitone sodium and with that of methohexitone alone. Three groups of 60 unpremedicated ASA physical state I or II women undergoing minor gynaecological interventions were studied. The end-point of induction of anaesthesia was inability to open eyes upon command. Dose-response curves were determined for each group with a probit procedure and compared with an isobolographic analysis. Midazolam was found to act in synergism with methohexitone for induction of anaesthesia. Twenty-seven percent ED50 for methohexitone was required in combination with 33% of ED50 for midazolam to achieve the ED50 of the combination. This degree of synergism is in agreement with that described in animal research.
Department of Anaesthesia and Intensive Care, Rebecca Sieff Hospital, Safed, Israel.
M
M
Tverskoy
I
I
Ben-Shlomo
J
J
Ezry
J
J
Finger
G
G
Fleyshman
D000328:Adult; D000771:Anesthesia, Intravenous; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008723:Methohexital / Q000494:pharmacology*; D008874:Midazolam / Q000494:pharmacology*; D008875:Middle Aged
D008723:Methohexital; D008874:Midazolam