Concanavalin A--horse radish peroxidase (Con A-HRP) labelling technique in detection and prognosis of cancer of uterine cervix.
The lectin binding capacity of the exfoliated epithelial cells of the uterine cervix was investigated with a modified concanavalin A - horse radish peroxidase labelling procedure. The normal healthy females exhibited a distinct rise in the percentage of labelled cells in comparison to those bearing squamous cell carcinoma. In the treated group, the responsive patients again exhibited a higher labelling percentage than the non-responsive patients - showing that the method is of both diagnostic and prognostic significance.
Sen
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Department of Tumor Biology, Chittaranja National Cancer Research Centre, Calcutta, India.
D000328:Adult; D002478:Cells, Cultured; D002584:Cervix Uteri / Q000166:cytology; D003208:Concanavalin A / Q000031:analogs & derivatives*; D005260:Female; D005500:Follow-Up Studies; D006735:Horseradish Peroxidase; D006801:Humans; D008875:Middle Aged; D010544:Peroxidases; D014407:Tumor Cells, Cultured; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*
C045779:concanavalin A-horseradish peroxidase conjugate; D003208:Concanavalin A; D006735:Horseradish Peroxidase; D010544:Peroxidases