[Chemoprevention of secondary abdominal echinococcosis--experimental study and clinical observation].
An experiment was carried out in white mice by intra-abdominal injection of protoscolices. A chemoprophylaxis of the secondary abdominal echinococcosis was practised by means of Mebendazole (Vermox) in a dosage of 50 mg/kg body weight daily for 90 days. The chemoprophylaxis started on the twentieth day after the infection. Three animal groups were divided: group 1--peroral application of the drug, group 2--injection of the drug, group 3--control group. The autopsy of the mice were carried out one month after the end of the chemoprophylaxis. An echinococcosis was diagnosable only in the control group. The application in one patient showed the same good result.
Wissenschaftlichen Institut für Gastroenterologie und Ernährung, Medizinischen Akademie Sofia.
G
G
Stojanow
D
D
Jurukowa
P
P
Meinhard
D000284:Administration, Oral; D000328:Adult; D015766:Albendazole; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage*; D001562:Benzimidazoles / Q000008:administration & dosage*; D004443:Echinococcosis / Q000517:prevention & control*; D004444:Echinococcosis, Hepatic / Q000601:surgery*; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D008463:Mebendazole / Q000008:administration & dosage*; D051379:Mice; D008815:Mice, Inbred Strains; D010532:Peritoneal Diseases / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D012008:Recurrence; D012422:Rupture, Spontaneous
D000871:Anthelmintics; D001562:Benzimidazoles; D008463:Mebendazole; D015766:Albendazole
Chemoprophylaxe der sekundären abdominalen Echinokokkose--experimentelle Untersuchung und klinische Beobachtung.