Delay of astrocyte reaction in the injured cerebral cortex of hypothyroid mouse.
Reactive change in the number of astrocytes in the stabbed cerebral cortex (layers II-VI) of the hypothyroid mouse was studied quantitatively over a 4-day period after stabbing, by immunohistochemistry for glial fibrillary acidic protein (GFAP) and S-100 protein. The reactive increase in the number of GFAP-positive astrocytes was delayed in the hypothyroid mouse, compared to that in the euthyroid mouse. The number of S-100-positive astrocytes neither increased nor decreased significantly in the hypothyroid and the euthyroid mice. [3H]Thymidine autoradiography showed that the time course and intensity of the reactive proliferation of astrocytes were the same in the hypothyroid mouse as in the euthyroid mouse. These results indicate that hypothyroidism delays the reactive expression of GFAP-antigen and delays the transformation of GFAP-negative astrocytes into GFAP-positive reactive astrocytes.
Miyake
T
T
Department of Pathology, Fukui Medical School, Japan.
Imamura
Y
Y
Fukuda
M
M
Kitamura
T
T
D000818:Animals; D001253:Astrocytes / Q000473:pathology*; D001930:Brain Injuries / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D002455:Cell Division; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005911:Gliosis / Q000209:etiology* / Q000473:pathology; D007037:Hypothyroidism / Q000378:metabolism / Q000503:physiopathology*; D007150:Immunohistochemistry; D051379:Mice; D008813:Mice, Inbred ICR; D009418:S100 Proteins / Q000378:metabolism; D013936:Thymidine
D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins; D013936:Thymidine