Cholangitis after the Kasai operation for biliary atresia.
One hundred seventy-nine episodes of cholangitis in 28 consecutive patients having a Kasai operation for biliary atresia during the past 3 1/2 years were analyzed. The diagnosis was made primarily on the basis of unexplained fever (greater than 38.0 degrees C). An increase in serum bilirubin or a decrease in bile volume and in bile bilirubin concentration were often confirmatory, but other laboratory data including serum hepatic enzymes and blood and bile culture data were of little or inconsistent value. All patients were treated with systemic antibiotics. The best results were obtained with third-generation cephalosporins or imipenemcilastatin with the addition of aminoglycosides in recalcitrant cases. Antibiotic therapy was modified if defervescence did not occur within the first 24 hours. Cholangitis refractory to antibiotics was aggressively treated with pulse steroid therapy, and in some cases, operative intervention, both with good clinical success (60% and 73%, respectively).
Department of Surgery, University of Colorado School of Medicine, Denver 80262.
S S
SS
Rothenberg
G P
GP
Schroter
F M
FM
Karrer
J R
JR
Lilly
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001656:Biliary Atresia / Q000601:surgery*; D002511:Cephalosporins / Q000627:therapeutic use; D002761:Cholangitis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D015377:Cilastatin / Q000627:therapeutic use; D000077728:Cilastatin, Imipenem Drug Combination; D004338:Drug Combinations / Q000627:therapeutic use; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D007223:Infant; D008775:Methylprednisolone / Q000627:therapeutic use; D011171:Portoenterostomy, Hepatic; D011182:Postoperative Care; D011183:Postoperative Complications / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D011379:Prognosis
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004338:Drug Combinations; D015377:Cilastatin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination; D008775:Methylprednisolone