[Loco-regional cancer chemotherapy with a new drug delivery system, "anticancer drug-fibrin clot"].
Five different types of anticancer drugs were individually entrapped into fibrin clots using our own material, "G.T.XIII" to provide an "anticancer drug-fibrin clot" for regional cancer chemotherapy. Anticancer drugs used in the present study were ADM, MMC, MTX, 5-FU and cDDP. The release of drugs from fibrin clots was studied in vitro. Each fibrin clot was intraperitoneally administered to cancer (AH-130)-bearing rats to evaluate the oncolytic effects. The activities of anticancer drugs delivered from the clots were maintained for more than two weeks. Survival terms of cancer bearing rats were remarkably prolonged with the anticancer drug-fibrin clots. Neither recurrence of ascites nor metastases of malignant cells was observed in the rats treated with such clots. Our newly devised anticancer drug-fibrin clots showed a sustained release of oncolytic drugs and favorable antineoplastic effects. This newly devised drug delivery system suggested a clinical potential for regional cancer chemotherapy.
Dept. of Surgery, Osaka National Hospital.
A
A
Sugitachi
Y
Y
Takatsuka
N
N
Numata
T
T
Kawahara
M
M
Hirata
T
T
Kido
I
I
Sakamoto
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D005176:Factor XIII / Q000627:therapeutic use; D005337:Fibrin / Q000627:therapeutic use*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D011379:Prognosis; D051381:Rats; D011919:Rats, Inbred Strains; D013917:Thrombin / Q000627:therapeutic use; D014018:Tissue Distribution
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; C050909:G-T-XIII; D005337:Fibrin; D005176:Factor XIII; D013917:Thrombin