[The formation and repair of DNA breaks in subpopulations of irradiated rat bone marrow cells].
Using the method of viscosimetry of alkaline lysates it was shown that the saturable DNA repair system was present in rat bone marrow cells which was described by a complex kinetics. Isokinetic fractionation in a sucrose and dextran gradient permitted to isolate three fractions differing in the ratio between differentiated cells and cells capable of division. The estimation of the postirradiation DNA repair kinetics in these cells revealed a comparatively high level of repair in normocytes which confirmed the presence of the relationship between the level of DNA repair in cells and their proliferative potency.
V A
VA
Tronov
A V
AV
Provotorov
G Iu
GIu
Kaz'min
V G
VG
Danilian
S P
SP
Rad'ko
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D001854:Bone Marrow Cells; D002455:Cell Division / Q000528:radiation effects; D002478:Cells, Cultured; D004249:DNA Damage; D004260:DNA Repair / Q000528:radiation effects*; D004277:DNA, Single-Stranded / Q000528:radiation effects; D011836:Radiation Tolerance; D051381:Rats; D011919:Rats, Inbred Strains; D014783:Viscosity
D004277:DNA, Single-Stranded
Obrazovanie i reparatsiia razryvov DNK v subpopuliatsiiakh obluchennykh kletok kostnogo mozga krys.