Ganglioside composition in human meningiomas.
The ganglioside composition in meningioma specimens from 20 patients was analyzed to find potential meningioma-associated structures. The characterization was performed by immunological staining with specific monoclonal antibodies to ganglioside antigens and fast atom bombardment-mass spectrometry. The major gangliosides were GM3 and GD3, and most of the meningioma specimens could be divided into a "GM3-rich" or a "GD3-rich" group. Gangliosides of the gangliotetraose series were represented by GM1, GD1a, GD1b, and GT1b, which were found in minor amounts in all the specimens. The ratios of GM1/GD1a and GD1a/GD1b differed from that in normal brain, and therefore existence of this series could not be explained by contamination with brain material. Ganglioside 3'-isoLM1, found in human malignant glioma, could not be detected in any meningioma specimen.
Department of Psychiatry and Neurochemistry, Gothenburg University, St. Jörgen Hospital, Hisings Backa, Sweden.
P
P
Davidsson
P
P
Fredman
V P
VP
Collins
H
H
von Holst
J E
JE
Mänsson
L
L
Svennerholm
D001923:Brain Chemistry; D004797:Enzyme-Linked Immunosorbent Assay; D005677:G(M1) Ganglioside / Q000032:analysis; D005679:G(M3) Ganglioside / Q000032:analysis; D005732:Gangliosides / Q000032:analysis*; D006801:Humans; D013058:Mass Spectrometry; D008577:Meningeal Neoplasms / Q000032:analysis*; D008579:Meningioma / Q000032:analysis*
D005679:G(M3) Ganglioside; D005732:Gangliosides; C021298:ganglioside, GD1a; C033851:ganglioside, GD1b; D005677:G(M1) Ganglioside; C016481:trisialoganglioside GT1; C026226:ganglioside, GD3