[The effect of metipamide on levels of sodium and potassium in erythrocytes].
The effect of metipamide on the level of Na+ and K+ in erythrocytes was studied in patients with essential hypertension. The control series consisted of healthy normotonics. In normotonics Nai+ and Ki+ were not affected in vitro, whereas in hypertonics Nai+ was found to be significantly increased (p less than 0.01) and Ki+ decreased (p less than 0.025). In vivo two subgroups of hypertonics were established: a) hypertonics with normal content of Nai+ (6.9 +/- 0.3.10(-3) mol/l) and b) hypertonics with increased content of Nai+ (9.2 +/- 0.3.10(-3) mol/l compared to 7.3 +/- 0.1.10(-3) mol/l, p less than 0.005). With respect to the given heterogeneity of the series, the response to metipamide treatment failed to be uniform. A part of the patients responded to therapy by diminished Nai+, manifesting one of the potential mechanisms of the antihypertensive effect of metipamide. The significant drop of Ki+ recorded in both subgroups of patients in the course of treatment demonstrated the potassium depleting effect of the drug.
M
M
Molitorisová
K
K
Sedláková
R
R
Dzúrik
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D066298:In Vitro Techniques; D007190:Indapamide / Q000031:analogs & derivatives / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*
D000959:Antihypertensive Agents; D004232:Diuretics; C050506:metipamide; D012964:Sodium; D007190:Indapamide; D011188:Potassium
Ucinok metipamidu na koncentráciu sodíka a draslíka v erytrocytoch.