Allergic airway disease caused by methyl tetrahydrophthalic anhydride in epoxy resin.
Work-associated rhinitis and asthma occurred in a subject exposed to methyl tetrahydrophthalic anhydride (MTHPA) used as a curing agent in an epoxy resin system. He displayed bronchial hyperreactivity in provocation with methacholine, as well as skin prick test positivity and specific immunoglobulin E (IgE) serum antibodies, against a conjugate of MTHPA and human serum albumin. Thus, it seems likely that the disease was caused by an IgE-mediated allergy.
Nielsen
J
J
Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden.
Welinder
H
H
Skerfving
S
S
D000328:Adult; D001249:Asthma / Q000139:chemically induced* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced* / Q000276:immunology; D010795:Phthalic Acids / Q000009:adverse effects*; D010796:Phthalic Anhydrides / Q000009:adverse effects*; D012130:Respiratory Hypersensitivity / Q000139:chemically induced* / Q000276:immunology; D012220:Rhinitis / Q000139:chemically induced* / Q000276:immunology
D010795:Phthalic Acids; D010796:Phthalic Anhydrides; D007073:Immunoglobulin E