Computer controlled infusion of propofol.
A computer controlled infusion pump was used to deliver propofol to two groups of eight patients undergoing body surface surgery. The patients were premedicated with morphine sulphate i.m. and anaesthesia was supplemented with 66% nitrous oxide in oxygen. Patients in group 1 breathed spontaneously, whereas patients in group 2 underwent artificial ventilation to a normal PaCO2. The computer program was designed to achieve and maintain a blood concentration of propofol 3 micrograms ml-1 as rapidly as possible, basing calculations on a three-compartment pharmacokinetic model. Mean blood propofol concentrations were found to be close to the predicted target from 10 to 120 min in group 1, but were 5-20% higher from 20 min in group 2.
Tackley
R M
RM
Department of Medical Physics, Bristol Royal Infirmary.
Lewis
G T
GT
Prys-Roberts
C
C
Boaden
R W
RW
Dixon
J
J
Harvey
J T
JT
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000008:administration & dosage*; D006801:Humans; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D008838:Microcomputers; D008875:Middle Aged; D010636:Phenols / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D015742:Propofol
D000777:Anesthetics; D010636:Phenols; D015742:Propofol