Exclusion of Usher syndrome gene from much of chromosome 4.
Usher syndrome is an autosomal recessive disease characterized by dual sensory impairments; affected individuals are born with a sensorineural hearing loss and ultimately lose their sight as retinitis pigmentosa develops. Conventional protein markers previously tested in a Louisiana Acadian kindred suggested tentative linkage to vitamin D-binding protein on chromosome 4. DNA linkage studies do not confirm this linkage relationship and exclude much of chromosome 4 as the site of the Usher syndrome gene in these families.
Smith
R J
RJ
Baylor College of Medicine, Houston, TX 77030.
Holcomb
J D
JD
Daiger
S P
SP
Caskey
C T
CT
Pelias
M Z
MZ
Alford
B R
BR
Fontenot
D D
DD
Hejtmancik
J F
JF
D001766:Blindness / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4; D003638:Deafness / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010375:Pedigree; D013577:Syndrome
D005819:Genetic Markers