Severe sublimate intoxication in the rat. Influence of thyroxine on renal enzymes of fatty acid degradation and on the survival rate of intoxicated rats.
1. The influence of thyroxine pretreatment on prognosis and some renal enzymes of fatty acid degradation of mercuric chloride intoxicated rats was studied. 2. Survival rates as observed over 10 d after 1.5 to 6.0 mg mercuric chloride/kg i.p. were not influenced by thyroxine pretreatment. 3. A quarter of survivors of both groups developed renal hypertrophy more pronounced in animals not treated with thyroxine. 4. Fatty acyl-CoA oxidase, the rate limiting enzyme of peroxisomal beta-oxidation was found to be depressed by about 50% 2 d after intoxication. This effect was prevented by thyroxine pretreatment. The other enzyme activities (carnitine acetyltransferase, carnitine-palmitoyltransferase and crotonoyl-CoA dependent NAD+ reduction) are essentially not influenced neither by intoxication nor by thyroxine pretreatment. 5. It is concluded that the prognosis of the intoxication is not correlated with fatty acid degradation enzymes.
Institute of Medical Chemistry, University of Vienna, Austria.
R
R
Kramar
W
W
Ulrich
M
M
Hohenegger
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy; D042962:Acyl-CoA Oxidase; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D008297:Male; D008627:Mercuric Chloride / Q000506:poisoning*; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000627:therapeutic use*
D005227:Fatty Acids; D008627:Mercuric Chloride; D010088:Oxidoreductases; D042962:Acyl-CoA Oxidase; D013974:Thyroxine