Imaging of brain tumors with L-3-[123I]iodo-alpha-methyl tyrosine and SPECT.
Carbon-11-labeled amino acids have been successfully used to image brain tumors by PET. This study was undertaken to evaluate the potential of L-3-[123I]-iodo-alpha-methyl tyrosine (123IMT) for metabolic imaging of brain tumors. Ten patients (glioblastoma, oligodendroglioma, lymphoma, and metastases) had early and delayed brain SPECT with a rotating gamma camera after i.v.-injection of 200-300 MBq 123IMT. In nine patients the tumors showed intense uptake of the radiotracer. Tumor-to-brain tissue ratios were between 1.4 and 2.6. 123IMT shows potentials for monitoring the effects of brain tumor therapy.
Biersack
H J
HJ
Department of Nuclear Medicine, University of Bonn, FRG.
Coenen
H H
HH
Stöcklin
G
G
Reichmann
K
K
Bockisch
A
A
Oehr
P
P
Kashab
M
M
Rollmann
O
O
D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D005910:Glioma / Q000000981:diagnostic imaging; D006801:Humans; D007457:Iodine Radioisotopes; D008223:Lymphoma / Q000000981:diagnostic imaging; D008781:Methyltyrosines / Q000138:chemical synthesis; D009837:Oligodendroglioma / Q000000981:diagnostic imaging; D014055:Tomography, Emission-Computed
D007457:Iodine Radioisotopes; D008781:Methyltyrosines; C030855:3-iodo-alpha-methyltyrosine