The [lactate]/[pyruvate] ratio and alcohol metabolism: experiments with naloxone in fasting normal male volunteers.
Naloxone administration to fasting normal male volunteers reverses the acute ethanol-induced increase in the blood [lactate]/[pyruvate] ratio, but fails to lower blood-ethanol concentration. The results are discussed in relation to factors affecting ethanol elimination and the mechanism of antagonism of acute alcohol intoxication by naloxone.
Morgan
C J
CJ
South Glamorgan Health Authority, Biomedical Research Laboratory, Cardiff, Wales.
Badawy
A A
AA
Thomas
D R
DR
Dando
T G
TG
Kirby
A
A
D000328:Adult; D000435:Alcoholic Intoxication / Q000097:blood; D000431:Ethanol / Q000493:pharmacokinetics*; D006801:Humans; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood*; D019289:Pyruvic Acid
D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D009270:Naloxone; D000431:Ethanol; D019289:Pyruvic Acid