[Cytotoxicity of benzethonium chloride on cultured mammalian cells].
Cytotoxicity of benzethonium chloride on cultured mammalian cells was studied. Growth of V79 cells, derived from Chinese hamster lung was inhibited by treatment with benzethonium chloride at above 30 micrograms/ml for 24 to 48 hr. Inhibitory effect on survival of V79 cells was not observed in cultures treated with benzethonium chloride at 3 micrograms/ml for 2 to 24 hr. Meanwhile, treatment with benzethonium chloride at 10 micrograms/ml for 2 to 24 hr elicited 11.4% to 75.0% inhibition of cell survival. Exposure of cells to benzethonium chloride at 3 to 30 micrograms/ml for 2 hr resulted in inhibition of DNA-, RNA-, and protein-syntheses of the cells, in a dose-dependent manner.
Tsujihama
M
M
D000818:Animals; D001558:Benzethonium / Q000633:toxicity*; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D000644:Quaternary Ammonium Compounds / Q000633:toxicity*
D000644:Quaternary Ammonium Compounds; D001558:Benzethonium