Prediction of ovulation.
The purpose of this investigation was to evaluate all available ovulatory diagnostics with respect to sensitivity, specificity, diagnostic specificity (predictive value of a positive test, PVP) and diagnostic sensitivity (predictive value of a negative test, PVN). Twenty-one ovulatory women with more than 3 years of infertility problems were included in the study. PVP and PVN were highest for detection of urinary luteinizing hormone (LH) peak at ovulation (PVP = 90%, PVN = 95%) and for serum-estradiol peak 1 day before ovulation (PVP = 83%, PVN = 97%). The predictive values were lower for all other tests. The PVP (54%) and PVN (90%) were rather low for detection of ovulation with vaginal electric impedance. However, all ovulations were predicted when urinary LH peak and vaginal impedance were combined. Two women were stimulated with human chorionic gonadotropin to investigate a possible connection between the LH peak and the preovulatory vaginal electric impedance. No close connection between them could be demonstrated. Basal body temperature should not be used for the prediction of ovulation (PVP = 25%). We suggest that ovulation should primarily be predicted from the identification of the urinary LH peak and that other methods be supplementary.
Department of Obstetrics and Gynecology, Central Hospital, Hillerød, Denmark.
J
J
Grinsted
J D
JD
Jacobsen
L
L
Grinsted
A
A
Schantz
H H
HH
Stenfoss
S P
SP
Nielsen
D000704:Analysis of Variance; D004958:Estradiol / Q000097:blood*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000652:urine*; D010060:Ovulation; D010061:Ovulation Detection; D010062:Ovulation Induction; D012044:Regression Analysis
D004958:Estradiol; D007986:Luteinizing Hormone