Rapid and sensitive determination of aprindine in serum by gas chromatography using a surface ionization detector.
A rapid and highly sensitive method for the determination in serum of aprindine, an antiarrhythmic drug, was developed employing gas chromatography with a surface ionization detector. No interfering peak from endogenous substances appeared when an organic phase was directly injected into the system after single extraction from a serum sample. A standard curve obtained was linear up to the serum level of 6 micrograms/ml, and the limit of sensitivity was 16 pg. The method described is applicable to routine therapeutic monitoring of serum concentrations of aprindine.
Department of Pharmaceutical Services, Kumamoto University Hospital, Japan.
H
H
Kawano
N
N
Inotsume
H
H
Arimoto
T
T
Fujii
M
M
Nakano
D000293:Adolescent; D001073:Aprindine / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics; D002849:Chromatography, Gas; D005260:Female; D005410:Flame Ionization; D006801:Humans; D007099:Imipramine / Q000097:blood; D007192:Indenes / Q000097:blood*
D007192:Indenes; D001073:Aprindine; D007099:Imipramine