[Effect of serotonin on the background activity of neurons in the isolated spinal cord semisegment of the rat].
The background activity of neurons in the isolated lumbar semisegment of 14-22 days old white rats was investigated before and after bath application of serotonin (5-HT, 1.10(-8)-1.10(-4) mol/l). 50% investigated neurons in dorsal horn and 70.6% interneurons in the ventral horn reacted on 5-HT. Excitation reactions prevailed. In the dorsal horn 5-HT evoked activation in 62.4% of responding interneurons, depression--in 8.4% and mixed reaction--in 29.2%. In the ventral horn 91.6% of all responses were activation reactions and only 8.4%--biphase ones. 5-HT induced discharges of motoneurons in the ventral root and ventral root depolarization. The data obtained have shown mainly the activation effect of 5-HT on the background activity of spinal neurons.
S G
SG
Khasabov
Z A
ZA
Tamarova
D000818:Animals; D005071:Evoked Potentials; D066298:In Vitro Techniques; D007395:Interneurons / Q000502:physiology*; D008564:Membrane Potentials; D009046:Motor Neurons / Q000502:physiology*; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*
D012701:Serotonin
Vliianie serotonina na fonovuiu aktivnost' neĭronov izolirovannogo polusegmenta spinnogo mozga krysiat.