Synthesis and biological properties of 1-methyl-2-[(4-aminophenyl)-sulfonyl-]amino-5-nitro imidazole.
The synthesis of 1-methyl-2-[(4-aminophenyl)sulfonyl] amino-5-nitroimidazole 5 is described. The new sulfonamide 5 shows a good activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria. Compound 5 is well absorbed in rats after oral administration but the plasma levels are inferior to those of sulfadiazine and sulfamethoxazole.
A
A
Bertolini
M
M
Castelli
F
F
Borella
L
L
Dall' Asta
A
A
Comini
D
D
Alberti
G
G
Coppi
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D008826:Microbial Sensitivity Tests; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D009593:Nitroimidazoles; D013449:Sulfonamides; C061005:1-methyl-2-((4-aminophenyl)sulfonyl)amino-5-nitroimidazole