[Role of prostanoids in the control of renal function in normal potassium balance and in acute experimental potassium depletion. 4. Relation of extrarenal parameters, renal function parameters and urinary excretion of prostanoids].
The renal function has been evaluated by clearance (cl.) method during hypotonic polyuria and successive moderate antidiuresis induced by a low dose of lysine-8-vasopressin; four 15 min and two 60 min cl. periods were performed, respectively. Glomerular filtration rate was estimated by creatinine cl.; the osmotic cl. (Cosm, CH2O), the absolute and fractional excretions of water, sodium, potassium and chloride were determined by usual methods. The urinary concentrations of PGE2, 6-keto-PGF1 alpha (6KPGF) and TxB2 were measured by RIA. The study protocol was applied in normal potassium balance and experimental potassium balance (KD), both in absence and presence of indomethacin. In KD groups with a potassium cumulative deficit of 198.4 +/- 22.2 meq (D3; n = 6) during polyuria significant correlations are consistent with the hypothesis that the lower the plasma potassium concentration is the higher the urinary chloride excretion and the inhibition of distal fractional chloride reabsorption. Moreover, by utilizing the polyuria and antidiuresis data pool, the effects of urine flow rate changes on PGE2 and 6KPGF urinary excretions are blunted as compared to normal potassium balance (n = 14). After indomethacin treatment (D3.I) the following functional relationships are disclosed: a) the lower the kaliemia is the lower the urinary chloride and potassium excretions and the higher the fractional isosmotic reabsorption; b) the lower the urinary potassium excretion is the lower the urinary chloride excretion. In both D3 and D3.I experimental groups the positive correlation between urinary chloride excretion and urinary potassium excretion is significant.
Agnoli
G C
GC
Borgatti
R
R
Cacciari
M
M
Garutti
C
C
Ikonomu
E
E
Lenzi
P
P
Marinelli
M
M
D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine*; D002712:Chlorides / Q000378:metabolism; D015232:Dinoprostone / Q000652:urine*; D004231:Diuresis / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000378:metabolism*; D007686:Kidney Tubules, Distal / Q000378:metabolism*; D008236:Lypressin / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism*; D011191:Potassium Deficiency / Q000378:metabolism; D013929:Thromboxane B2 / Q000652:urine*
D002712:Chlorides; D008236:Lypressin; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D015232:Dinoprostone; D011188:Potassium; D007213:Indomethacin
Ulteriori ricerche sul ruolo dei prostanoidi nel controllo della funzione renale in bilancio potassico normale e in deplezione potassica acuta sperimentale. IV: Relazioni tra parametri extrarenali, parametri funzionali renali ed escrezioni urinarie dei prostanoidi.