Favourable effect of flunarizine on the recovery from hemiparesis in rats with intracerebral hematomas.
In 25 rats, an intracerebral hematoma was created in the foreleg area of the motor cortex by injection of 50 microliters blood. After the lesion, 13 were treated with flunarizine and 12 with the solvent. Neurological testing was performed by measuring the running time on a rotating platform. In animals with hemiparesis, the flunarizine group (n = 7) showed a significantly (P less than 0.05) better recovery than the control group (n = 8). No significant differences occurred in animals without neurological deficits (flunarizine: n = 6, control: n = 4). So the effect of the drug is not due to a non-specific activation; it may partially cure neurological deficits caused by intracerebral hematoma.
Kleiser
B
B
Department of Neurology, University of Ulm, F.R.G.
Van Reempts
J
J
Van Deuren
B
B
Haseldonckx
M
M
Borgers
M
M
Horn
E
E
Esseling
K
K
Widder
B
B
Kornhuber
H H
HH
D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology*; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000503:physiopathology; D005444:Flunarizine / Q000627:therapeutic use*; D006406:Hematoma / Q000188:drug therapy* / Q000503:physiopathology; D006429:Hemiplegia / Q000188:drug therapy* / Q000209:etiology; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D005444:Flunarizine