Vaccination trial against canine visceral leishmaniasis. Phocean Veterinary Study Group on Visceral Leishmaniasis.
In a double-blind study 393 seronegative dogs, residing in a holoendemic area for Leishmania donovani infantum infection, were randomly assigned to an immunization with a partly purified L.d. infantum-derived preparation, or received adjuvant only. During the first year of the study period the rate of infection was significantly higher in the vaccinated group than in the control one (P less than 0.05), but this difference disappeared during the second year (P = 0.44). Since a similar immunization protocol conferred resistance against experimental murine leishmaniasis, these results stress the differences that may exist between the natural hosts of Leishmania parasites and experimental animal substitutes.
Dunan
S
S
INSERM U 313, Pitié-Salpètrière School of Medicine, Paris, France.
Frommel
D
D
Monjour
L
L
Ogunkolade
B W
BW
Cruz
A
A
Quilici
M
M
D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D015153:Blotting, Western; D004198:Disease Susceptibility; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D004311:Double-Blind Method; D007893:Leishmania donovani / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000276:immunology / Q000662:veterinary*; D011897:Random Allocation; D013997:Time Factors; D014611:Vaccination / Q000662:veterinary*
D000913:Antibodies, Protozoan