Effects of inoculations with Eimeria zuernii on young calves treated with decoquinate or narasin with or without dexamethasone.
Sixteen 7-week-old Holstein male calves were inoculated with sporulated oocysts of Eimeria zuernii. Four calves (controls) were euthanatized and necropsied at 14 and 20 days after inoculation (DAI). Two calves were treated with 20 mg of dexamethasone (IM) on 13, 14, and 15 DAI and euthanatized and necropsied 17 DAI and 2 calves were given similar treatments and necropsied 20 DAI. The 8 other calves were euthanatized and necropsied 20 DAI. Two were started on the anticoccidial drug decoquinate in feed 13 DAI; 2 others were given decoquinate on the same schedule plus dexamethasone on 13,14, and 15 DAI. Two calves were given the antibiotic narasin in feed beginning 13 DAI and 2 calves were given parasin on the same schedule plus dexamethasone on 13,14, and 15 DAI. All calves, except 2 controls necropsied 14 DAI and 4 calves given decoquinate, discharged moderate-to-large numbers of oocysts in feces and had moderate-to-serve changes in fecal consistency. Histologic examinations revealed large numbers of endogenous stages in tissues of calves treated or not treated with dexamethasone. Few endogenous stages were observed in tissues from calves that were given decoquinate or decoquinate plus dexamethasone. Calves given narasin or narasin plus dexamethasone had moderate-to-large numbers of endogenous stages in the tissues.
Fitzgerald
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PR
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Mansfield
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ME
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology; D003048:Coccidiosis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D003049:Coccidiostats / Q000494:pharmacology*; D003667:Decoquinate / Q000627:therapeutic use*; D003907:Dexamethasone / Q000494:pharmacology*; D004539:Eimeria / Q000187:drug effects; D005243:Feces / Q000469:parasitology; D006912:Hydroxyquinolines / Q000627:therapeutic use*; D007814:Larva; D008297:Male; D011714:Pyrans / Q000627:therapeutic use*; D011897:Random Allocation; D013997:Time Factors
D003049:Coccidiostats; D006912:Hydroxyquinolines; D011714:Pyrans; D003667:Decoquinate; D003907:Dexamethasone; C013612:narasin