[Theoretical analysis of the DNA duplication mechanisms in the prokaryotic genomes on the basis of repeats].
In the present work a theoretical analysis of the molecular mechanisms on duplications emergence in the genomes of prokaryotes on the basis of direct repeats has been carried out. The correlations obtained have shown, that the duplication rate depends on such parameters as the distance between repeated regions, repeats nucleotide composition and the number of homology damages in them. It has been revealed that the rate of duplications decreases more readily than the deletion rate upon the growth of the distance between the repeats. Such prevalence of deletions over duplications must lead to the elimination of various types of direct repeats from the prokaryotic genomes in the course of their evolution.
Kolchanov
N A
NA
Solov'ev
V V
VV
Kel'
A E
AE
D002477:Cells; D002872:Chromosome Deletion; D004247:DNA / Q000235:genetics; D004261:DNA Replication; D008962:Models, Theoretical; D005810:Multigene Family; D009692:Nucleic Acid Heteroduplexes; D011387:Prokaryotic Cells; D012091:Repetitive Sequences, Nucleic Acid
D009692:Nucleic Acid Heteroduplexes; D004247:DNA
Teoreticheskiĭ analiz mekhanizmov duplikatsiĭ DNK v genomakh prokariot na osnove povtorov.