Sample sizes for constructing confidence intervals and testing hypotheses.
Although estimation and confidence intervals have become popular alternatives to hypothesis testing and p-values, statisticians usually determine sample sizes for randomized clinical trials by controlling the power of a statistical test at an appropriate alternative, even those statisticians who recommend the use of confidence intervals for inference. There is merit in achieving consistency in the techniques for data analysis and sample size determination. To that end, this paper compares sample size determination with use of the length of the confidence interval with that obtained by control of power.
Bristol
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Development Department, CIBA-GEIGY Corporation, Summit, NJ 07901.
D000787:Angina Pectoris / Q000188:drug therapy / Q000503:physiopathology; D002986:Clinical Trials as Topic / Q000379:methods*; D004562:Electrocardiography; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D013223:Statistics as Topic