Effect of indomethacin, diclofenac sodium and sodium salicylate on peripheral blood cell counts in sublethally gamma-irradiated mice.
Treatment with indomethacin and diclofenac sodium was found to increase granulocyte counts in the blood of sublethally gamma-irradiated mice. Treatment with sodium salicylate was ineffective in this respect, administration of sodium salicylate together with indomethacin even decreased the indomethacin-induced effects. The results suggest that the hemopoiesis-stimulating effects of non-steroidal anti-inflammatory drugs cannot be correlated with the anti-inflammatory activity but rather with the side effects of these compounds, including the action on gastro-intestinal prostanoid production. This conclusion doubts on the possibility of the usefulness of non-steroidal anti-inflammatory drugs in conditions of the radiation syndrome.
Pospísil
M
M
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
Netíková
J
J
Kozubík
A
A
Pipalová
I
I
D000818:Animals; D001772:Blood Cell Count; D004008:Diclofenac / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006410:Hematopoiesis / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000188:drug therapy*; D012980:Sodium Salicylate / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
D004008:Diclofenac; D012980:Sodium Salicylate; D007213:Indomethacin