Pharmacokinetics of intravenous buprenorphine in children.
Buprenorphine (3 micrograms kg-1) was given intravenously as premedication to small children (age 4-7 years) undergoing minor surgery. Because of the rapid decline of the plasma buprenorphine concentrations, the terminal elimination half-life could not be estimated reliably. Given this constraint, values of clearance appeared to be higher than those in adults but values of Vss were similar.
Department of Clinical Pharmacology, University of Helsinki, Finland.
K T
KT
Olkkola
E L
EL
Maunuksela
R
R
Korpela
D002047:Buprenorphine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D011863:Radioimmunoassay
D002047:Buprenorphine