Synthesis, antilipidemic and platelet antiaggregatory activity of 2-aminobenzimidazole amide derivatives.
The synthesis and preliminary pharmacological evaluation of 2-aminobenzimidazole amide derivatives are reported. None of these compounds showed antilipidemic or platelet antiaggregatory activity comparable to that of drugs used in therapy.
Caroti
P
P
Istituto di Chimica Farmaceutica, Università di Pisa, Italy.
Ceccotti
C
C
Da Settimo
F
F
Primofiore
G
G
Franzone
J S
JS
Reboani
M C
MC
Cravanzola
C
C
D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D001562:Benzimidazoles; D000960:Hypolipidemic Agents; D010975:Platelet Aggregation Inhibitors