New humantenine-type alkaloids from Gelsemium elegans.
The alkaloid extract of the whole plant of Gelsemium elegans has afforded four new alkaloids: N-desmethoxyrankinidine [1], 11-hydroxrankinidine [3], 11-hydroxyhuman-humantenine [4] and humantenirine [6]. The structures of 5 was established through X-ray crystallographic analysis, and the structures of the other three new alkaloids were deduced by spectral analysis (1H, 13C, APT, 2D-COSY and 2D-HETCOR).
Lin
L Z
LZ
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.
Cordell
G A
GA
Ni
C Z
CZ
Clardy
J
J
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification*; D008958:Models, Molecular; D015394:Molecular Structure; D013057:Spectrum Analysis
D000470:Alkaloids; D004365:Drugs, Chinese Herbal