Meal associated changes in brown fat thermogenesis and glycogen.
Data indicate a close association between a decrease in feeding-induced brown adipose tissue (BAT) thermogenesis and an increase in food consumption. The present study examines the hypothesis that feeding-induced BAT thermogenesis, or feeding-induced changes in BAT glycogen, a mobile form of energy store and a correlate of BAT thermogenesis, may modulate feeding behavior. We report that propranolol, which completely abolished meal-induced BAT thermogenesis, did not evoke intake of a larger meal. Though BAT glycogen concentration is a sensitive measure of the state of feeding, on a meal to meal basis it does not correlate with hunger and satiety. Hence the hypothesis is not supported by the current data. We also report that meal-induced BAT hypertrophy and glycogen deposition can be dissociated from meal-induced BAT thermogenesis.
Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Sepulveda, CA 91343.
Z
Z
Glick
A
A
Uncyk
J
J
Lupien
L
L
Schmidt
D002001:Adipose Tissue, Brown / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology*; D006003:Glycogen / Q000032:analysis*; D006150:Guanine Nucleotides / Q000378:metabolism*; D006153:Guanosine Diphosphate / Q000378:metabolism*; D008099:Liver / Q000032:analysis; D008297:Male; D009132:Muscles / Q000032:analysis; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D006150:Guanine Nucleotides; D006153:Guanosine Diphosphate; D006003:Glycogen; D011433:Propranolol