Radioisotope studies in monitoring of Gaucher's disease and its treatment.
Radioisotope studies (blood volume, spleen function, and ferrokinetics) were performed in seven patients with chronic (type 1) Gaucher's disease. Interestingly, the 52Fe scans and spleen histology demonstrated extramedullary haemopoiesis in the liver and spleen. Radioisotope measurements (red cell volume, plasma volume, red cell pool, damaged cell clearance, spleen blood flow, 59Fe clearance, red cell utilization and 52Fe scans) provide methods for accurate measurement of the bone marrow and spleen function, thereby enabling prediction of the most suitable time for splenectomy, in the treatment of patients with Gaucher's disease.
Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
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Dokal
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Deenmamode
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Lewis
D005776:Gaucher Disease / Q000000981:diagnostic imaging* / Q000628:therapy; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D007504:Iron Radioisotopes; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging / Q000473:pathology
D007504:Iron Radioisotopes