Surgery and radiotherapy in the treatment of early stage uterine sarcomas.
Twenty-three patients with early stage uterine sarcomas underwent surgery (5 patients) or surgery and pelvic irradiation (18 patients). Twelve (52%) of the patients developed a recurrence: relapsing disease was pelvic in 3 (25%) of them, extrapelvic in 8 (66.7%) and both pelvic and extrapelvic in one (8.3%). Out of the whole series the 2- and 5-year actuarial survival rates were 61% and 33% respectively. Among the patients with leiomyosarcoma the 2- and 5-year actuarial survival rates were 54% and 39% respectively. Among the patients with carcinosarcoma the 2- and 5-year actuarial survival rates were 66% and 23% respectively. The high incidence of extrapelvic recurrences after locoregional treatment seems to suggest the use of an adjuvant chemotherapy in the management of patients with early stage uterine sarcomas.
Department of Obstetrics and Gynecology, University of Pisa, Italy.
A
A
Gadducci
M G
MG
Fabrini
V
V
Facchini
F
F
Ducci
S
S
Colosimo
T
T
Dell'Arciprete
S
S
Moda
P
P
Fioretti
D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012509:Sarcoma / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D014594:Uterine Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*