[Can naproxen impair menstruation?].
Two patients are described experiencing interruption of menstrual blood flow soon after taking a tablet of naproxen (250 or 275 mg). The patients were young women (19 and 34 years) with a diagnosis of primary dysmenorrhoea: menstruation had otherwise been regular and of normal duration. Normal menstruation is influenced by prostaglandins in a complex way. Non-steroidal anti-inflammatory drugs are known to reduce the amount of blood loss in menorrhagia. It is suggested that the effects of cyclo-oxygenase inhibitors on the metabolism of prostaglandins may occasionally interfere with the normal course of menstruation.
Meyboom
R H
RH
Bonsema
K
K
Huisman-Klein Haneveld
P M
PM
D000328:Adult; D004412:Dysmenorrhea / Q000188:drug therapy; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects*; D009288:Naproxen / Q000009:adverse effects* / Q000627:therapeutic use; D011453:Prostaglandins / Q000378:metabolism
D011453:Prostaglandins; D009288:Naproxen
Kan naproxen de menstruatie verstoren?