Modelling the occurrence and pathology of Alzheimer's disease.
Our work has confirmed that of St. George-Hyslop and colleagues, suggesting FAD linkage to the short arm of chromosome 21 in outbred families with a presenile onset of the disease. Future genetic studies should help clarify the current apparent discrepancies between certain laboratories and ultimately lead to a better understanding of the variables which predispose individuals to the disease.
Hardy
J A
JA
Department of Biochemistry, St. Mary's Hospital Medical School, London.
Goate
A M
AM
Owen
M J
MJ
Mullan
M J
MJ
Rossor
M N
MN
Pearson
R C
RC
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D002891:Chromosomes, Human, Pair 21; D008040:Genetic Linkage; D006801:Humans; D008875:Middle Aged