Hostility and hallucinations as a consequence of midazolam administration.
A 74-year-old woman experienced an apparent psychotic reaction several hours after administration of iv midazolam as a premedicant for gastroscopy. The reaction included confusion, hallucinations, and hostility and required administration of haloperidol to calm her. The woman subsequently underwent colonoscopy with meperidine as a premedication and experienced no behavioral changes. Although other causes cannot be completely ruled out, the evidence points strongly to midazolam as the precipitating agent for the psychotic reaction.
Burnakis
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TG
Department of Pharmacy, Wyandotte Hospital, MI 48192.
Berman
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DE
D000368:Aged; D005260:Female; D006212:Hallucinations / Q000139:chemically induced*; D006791:Hostility; D006801:Humans; D008874:Midazolam / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000523:psychology*
D008874:Midazolam