title: The major and minor chicken vitellogenin genes are each adjacent to partially deleted pseudogene copies of the other.
abstract: The major chicken vitellogenin gene (VTGII) has previously been cloned and sequenced. We now report the isolation of genomic clones that encompass a minor chicken vitellogenin gene (VTGIII) which is also expressed in the liver in response to estradiol. Our analysis reveals that a pseudogene for VTGII (psi VTGII) lies 1,426 base pairs upstream of this VTGIII gene. A reevaluation of published sequence data reveals that the converse is also true, namely, that a pseudogene for VTGIII (psi VTGIII) lies 1,345 base pairs downstream of the VTGII gene. Our results show that a 335-base-pair deletion has removed the psi VTGIII promoter and cap site but left residual estrogen response element in a region where nuclease-hypersensitive sites have been reported to be induced in response to estradiol.
authors: Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
authors: R
authors: R
authors: Silva
authors: A H
authors: AH
authors: Fischer
authors: J B
authors: JB
authors: Burch
mesh_terms: D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002645:Chickens / Q000235:genetics*; D002872:Chromosome Deletion; D003001:Cloning, Molecular; D015180:Electrophoresis, Gel, Two-Dimensional; D008969:Molecular Sequence Data; D011544:Pseudogenes; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D014819:Vitellogenins / Q000235:genetics*
chemical_list: D014819:Vitellogenins