[Histologic distribution of anti-glioma monoclonal antibody SZ-39 in human xenograft brain tumors].
131I-labeled anti-glioma monoclonal antibody SZ-39 was injected intraperitoneally into nude mice bearing xenograft human glioma, ependymoma and intracranial metastatic adenocarcinoma. Subsequent gamma-imaging and assessment of radioactivity showed selective accumulation of antibody in the glioma. Quantitative autoradiography supported the results of radiolocalization observed in vivo in different brain tumors and normal tissues. It was also shown that antibody SZ-39 was specially localized to viable glioma cells and closely associated with their cell membrane. Yet, it was not bound to fibrous or necrotic areas. 131I-normal mouse IgG was distributed in a nonspecific pattern in the glioma. These studies demonstrated the specificity of SZ-39 in vivo which may be useful in clinical diagnostic guiding and treatment.
Yang
W L
WL
Neurologic Laboratory, Suzhou Medical College.
D000230:Adenocarcinoma / Q000276:immunology / Q000556:secondary; D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis*; D000912:Antibodies, Neoplasm / Q000032:analysis*; D001345:Autoradiography; D001932:Brain Neoplasms / Q000276:immunology*; D004806:Ependymoma / Q000276:immunology; D005910:Glioma / Q000276:immunology*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014018:Tissue Distribution
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm