title: Impaired differentiation of Ig A-B cell precursors in the Peyer's patches of protein depleted rats.
abstract: The aim of this study has been set on Ig A plasma cell precursors that are found in the Peyer's patches. In a previous work it has been shown that protein deficiency at weaning led to the presence in the Peyer's patch of very immature B cells, mostly cu+ su- cells. In this report we demonstrate the c mu+ s mu- cells comprise a (c mu OX7)+ s mu- cell population that is predominant in the protein-deprived rats (41.5 versus 16.8 in 39 day-old control rats). Protein refeeding reinitiates the differentiation as follows: (a) the (c mu OX7)+ s mu- cell population was able to differentiate to (cs mu+ as in the normal Peyer's patch (53.6 versus 44.9 in 39 day-old control rats); (b) the switching of sIg M-bearing cells to sIg A-bearing cells occurs in a restricted pattern; only 27.9 versus 47.6 in the 60 day-old control rats; (c) concomitantly, protein-refed rats showed a low absolute number of W3/13+ and W3/25+ T cells. Therefore, this experimental model of immunodeficiency provides further evidence that specialized T helper cells or their soluble factors are needed for Ig A-B cell differentiation "in vivo."
authors: Department of Food Science and Experimental Nutrition, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
authors: M C
authors: MC
authors: Lopez
authors: M E
authors: ME
authors: Roux
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002454:Cell Differentiation; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000473:pathology; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D007075:Immunoglobulin M / Q000378:metabolism; D010581:Peyer's Patches / Q000276:immunology* / Q000473:pathology; D011488:Protein Deficiency / Q000276:immunology* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D007071:Immunoglobulin A, Secretory; D007075:Immunoglobulin M