Elevated antidepressant plasma levels after addition of fluoxetine.
Four patients treated with tricyclic antidepressants and one patient treated with trazodone all demonstrated marked increases in plasma levels of these drugs after the addition of fluoxetine. Such increases could increase adverse effects.
Aranow
A B
AB
Laboratories for Psychiatric Research, McLean Hospital, Belmont, MA 02178.
Hudson
J I
JI
Pope
H G
HG
Grady
T A
TA
Laage
T A
TA
Bell
I R
IR
Cole
J O
JO
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000929:Antidepressive Agents, Tricyclic / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D014196:Trazodone / Q000097:blood*
D000929:Antidepressive Agents, Tricyclic; D004338:Drug Combinations; D005473:Fluoxetine; D014196:Trazodone