[Cyclosporin, toxicity and efficacy in rejection of liver allografts in the rat].
52 orthotopic liver transplants were performed in DA to lewis rat strain combination, in order to appreciate cyclosporine toxicity, and efficacy at doses of 10 mg/kg day (G II) and 20 mg/kg/day (GIII) compared to liver allografts in DA/lewis rats. The first signs of cyclosporine hepatotoxicity are biological (increased plasma level of bilirubine and transaminase) that were noticed at the dose of 20 mg/kg/day. Histological signs (cells inclusion, hepatocytic necrosis) appeared late and were less constant as well as difficult to assert creatinine plasma level was the best reflect of cyclosporine nephrotoxicity. Renal toxicity was practically constant at the dose of 20 mg/kg/day. In spite of renal and hepatic toxicity, cyclosporin by itself, allows the abolition of the acute rejection of liver allografts in the rat.
Settaf
A
A
Groupe de Recherche de Chirurgie Hépatique, Hôpital Paul Brousse, Villejuif.
Gugenheim
J
J
Lahlou
M K
MK
Gigou
M
M
Capron-Laudereau
M
M
Charpentier
B
B
Reynes
M
M
Lokiec
F
F
Bismuth
H
H
D000818:Animals; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000097:blood / Q000494:pharmacology* / Q000633:toxicity; D006084:Graft Rejection / Q000187:drug effects*; D007165:Immunosuppression Therapy; D007674:Kidney Diseases / Q000139:chemically induced; D016031:Liver Transplantation; D051381:Rats; D011917:Rats, Inbred Lew; D000637:Transaminases / Q000097:blood; D014184:Transplantation, Homologous
D003524:Cyclosporins; D003404:Creatinine; D000637:Transaminases; D001663:Bilirubin
Ciclosporine, toxicité et efficacité dans le rejet des allogreffes hépatiques chez le rat.