Duodenal ulcers are associated with a depletion of duodenal calcitonin gene-related peptide-like immunoreactivity in rats.
Calcitonin gene-related peptide-like immunoreactivity (CGRP-li) was decreased in duodenal samples from animals treated with ulcerogens such as dulcerozine, cysteamine or mepirizole. The degree of these experimental ulcers was inversely correlated with the levels of duodenal CGRP-li. These findings show that endogenous CGRP may play an important role in duodenal ulcerogenesis.
Evangelista
S
S
Pharmacology Department, Menarini Pharmaceuticals, Firenze, Italy.
Renzi
D
D
Mantellini
P
P
Surrenti
C
C
Meli
A
A
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D003543:Cysteamine; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000378:metabolism*; D004386:Duodenum / Q000378:metabolism*; D004840:Epirizole; D005260:Female; D009479:Neuropeptides / Q000276:immunology / Q000378:metabolism*; D011743:Pyrimidines; D051381:Rats; D011919:Rats, Inbred Strains
D009479:Neuropeptides; D011743:Pyrimidines; C043452:dulcerozine; D004840:Epirizole; D003543:Cysteamine; D015740:Calcitonin Gene-Related Peptide