title: [Experimental substantiation of the use of regional detoxication therapy in acute ischemia of the limbs].
abstract: In the experiment on dogs, the authors modelled acute ischemia of the extremities and studied the activity of lactate dehydrogenase in the blood serum. In circulatory ischemia for 2 and 4 h, the metabolism in muscular tissue normalized by day 30 after restoration of blood flow. Circulatory hypoxia for 7 and 9 h led to failure of the compensatory-adaptive mechanisms of homeostasis of the muscular tissue and required performance of regional detoxication therapy before restoration of circulation in the extremity.
authors: M G
authors: MG
authors: Gonchar'
authors: Zh M
authors: ZhM
authors: Vavrik
authors: S N
authors: SN
authors: Genyk
mesh_terms: D000208:Acute Disease; D000818:Animals; D001775:Blood Circulation; D004796:Clinical Enzyme Tests; D004285:Dogs; D005121:Extremities / Q000098:blood supply*; D007511:Ischemia / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D013997:Time Factors
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
vernacular_title: Eksperimental'noe obosnovanie primeneniia regionarnoĭ detoksikatsionnoĭ terapii pri ostroĭ ishemii konechnosteĭ.