Use of dopexamine hydrochloride in patients with septic shock.
The short and long-term hemodynamic effects of iv dopexamine hydrochloride (DPX) were studied in ten patients with septic shock. In the short-term study, a dose-dependent increase in cardiac index and heart rate, and a dose-dependent decrease in systemic vascular resistance were demonstrated. These effects diminished gradually during the long-term study, suggesting a problem of tolerance. Although the administration of DPX during septic shock appeared to be relatively safe, its hemodynamic effects suggest that it may be more indicated in selected patients with a low cardiac output.
Colardyn
F C
FC
Department of Intensive Care, University Hospital, State University, Gent, Belgium.
Vandenbogaerde
J F
JF
Vogelaers
D P
DP
Verbeke
J H
JH
D000328:Adult; D000368:Aged; D004298:Dopamine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009846:Oliguria / Q000503:physiopathology / Q000652:urine; D012772:Shock, Septic / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D013997:Time Factors
C046318:dopexamine; D004298:Dopamine