[11 beta-hydroxylation of 16 alpha-methyl-Reichstein's compound S 21-acetate by Curvularia lunata].
The conversion of 16 alpha-methyl-Reichstein's compound S 21-acetate (I) to 16 alpha-methyl-hydrocortisone (II) by the mycelium Curvularia lunata AS3.4381 was studied. Maximal 11 beta-hydroxylating activity of the mycelium was found during cultivation of the microorganism by 24h. Inhibition of the ethanol to the 11 beta-hydroxylating activity was obvious. The yield of 55.4% (II) (W/W) could be achieved during conversion of 0.15% substrate at 72 h.
Huang
S H
SH
Xu
S W
SW
Fa
Y H
YH
D006854:Hydrocortisone / Q000031:analogs & derivatives*; D006900:Hydroxylation; D003904:Mitosporic Fungi / Q000378:metabolism*
C061386:16-methylhydrocortisone; D006854:Hydrocortisone