HLA-DR/DQ antigens and reactivity to B cell alloantigen D8/17 in Indian patients with rheumatic heart disease.
D8/17, a B cell alloantigen, and its occurrence with DR/DQ antigens was examined in 54 patients with rheumatic heart disease and matched North Indian controls. Thirty-four patients (62.9%) carried D8/17 as compared with a frequency of 12.5% in controls (chi 2 by Yates', 18.75; p less than 0.0001). A marginally increased frequency of human leukocyte antigen (HLA)-DR3 (44.2% vs. 28.8%) and a significantly reduced frequency of HLA-DR2 (21.1% vs. 46.6%; p less than 0.005) was observed in patients as compared with controls. However, the most significant positive association was observed with HLA-DQw2 (63.4% in patients and 31.5% in controls; chi 2 by Yates', 9.85; p less than 0.005). The DQw2 association was significant only in the D8/17-positive patients. These observations suggest that the disease susceptibility gene in rheumatic heart disease may be nearer to the HLA-DQ locus than to the HLA-DR.
Taneja
V
V
Department of Anatomy, All India Institute of Medical Sciences, New Delhi.
Mehra
N K
NK
Reddy
K S
KS
Narula
J
J
Tandon
R
R
Vaidya
M C
MC
Bhatia
M L
ML
D000944:Antigens, Differentiation, B-Lymphocyte / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007194:India; D007519:Isoantigens / Q000235:genetics*; D008297:Male; D010641:Phenotype; D012214:Rheumatic Heart Disease / Q000235:genetics*
D000944:Antigens, Differentiation, B-Lymphocyte; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D007519:Isoantigens