[Effects of influenza on the state of vessels in the stria vascularis of the spiral organ (an experimental study)].
The effect of influenza infection on vessels in the stria vascularis of the spiral organ of 60 guinea-pigs infected intranasally or intranasally and intracordially was investigated. The vascular network was examined 1, 3, 7 or 14 days after infection. The animals that were infected intranasally were treated with dimephosphone administered for 7 days intraesophageally. The vessel diameter and blood flow, alkaline phosphatase in the vascular wall, adventitial cells and epithelial cells of the stripe were measured. It was found that the infection produced a strong effect on the vascular network of the stripe, especially 1 day after infection: the caliber of vessels diminished, formed elements accumulated in their lumen, alkaline phosphatase in the vascular wall and adventitial cells decreased. On day 3 alkaline phosphatase activity increased and vessel diameter normalized but congestive changes developed. Dimephosphone given for 7 days had a vasodilatory effect. These observations clarify certain aspects of the origin of hearing disorders accompanying influenza.
Lebedev
S I
SI
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D003051:Cochlea; D006168:Guinea Pigs; D006311:Hearing Disorders / Q000209:etiology; D009925:Organ of Corti / Q000098:blood supply*; D009943:Organophosphorus Compounds / Q000627:therapeutic use; D009976:Orthomyxoviridae Infections / Q000150:complications / Q000503:physiopathology*; D013316:Stria Vascularis; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009943:Organophosphorus Compounds; C049638:dimephosphon
Vliianie grippoznoĭ infektsii na sostoianie sosudov sosudistoĭ polosti spiral'nogo organa (éksperimental'noe issledovanie).