[Low activity of antioxidant enzymes in tumor cells as a factor of oxygen dependence of antitumor cytotoxicity of macrophages].
The author studied dependence of cytotoxicity of peritoneal macrophages of Wistar rats on the production of active oxygen form (AOF) and activity of antioxidative enzymes in target cells. Low activity of glutathione-peroxidase and glutathione-reductase in K562 cells could be the cause of macrophage cytotoxicity realization along AOF-dependent way.
Borunov
E V
EV
Khavalkin
I V
IV
Smirnova
L P
LP
Shchepetkin
I A
IA
Lankin
V Z
VZ
Vasil'ev
N V
NV
D000818:Animals; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000276:immunology / Q000378:metabolism*; D010100:Oxygen; D051381:Rats; D013053:Spectrophotometry; D014407:Tumor Cells, Cultured
D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D010100:Oxygen
Nizkaia aktivnost' antioksidantnykh fermentov v opukholevykh kletkakh kak faktor kislorodnoĭ zavisimosti protivoopukholevoĭ tsitotoksichnosti makrofagov.