[The effect of carnosine on indicators of free radical lipid oxidation during acute stress in rats].
The effect of carnosine intraperitoneal injection in rats (in doses 0.2, 2.0 or 20 mg/kg) on the vegetative parameters (arterial blood pressure, Hildebrandt index), the content of free radical oxidation (FRO) products and superoxide dismutase activity in serum and brain homogenates and brain lipid composition under normal condition and after different stress forms have been investigated. The carnosine injection in dose 20 mg/kg preserves and increase in arterial pressure and Hildebrandt index at all steps of stress development. The phase non-unidirectional changes in studied biochemical parameters have been revealed depending on the level of stress development in animals under control. The unidirectional and dose-dependent changes of phospholipid content and the level of brain lipids, decrease of FRO products in tissue and brain cholesterol, the increase of the superoxide dismutase activity of serum and brain homogenates have been found in intact and stressed animals after carnosine injection. A comparison of carnosine pharmacokinetics with concentration dependences of the antioxidative effect under in vitro and in vivo experiments comes to conclusion concerning the carnosine indirect adaptogenic action.
Guliaeva
N V
NV
Obidin
A B
AB
Levshina
I P
IP
Filonenko
A V
AV
Dupin
A M
AM
Boldyrev
A A
AA
D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D002336:Carnosine / Q000378:metabolism / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals; D007103:Immobilization; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D051379:Mice; D010084:Oxidation-Reduction; D013312:Stress, Physiological / Q000378:metabolism* / Q000503:physiopathology; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism
D004151:Dipeptides; D005609:Free Radicals; D008055:Lipids; D002336:Carnosine; D013482:Superoxide Dismutase
Vliianie karnozina na pokazateli svobodnoradikal'nogo okisleniia lipidov pri ostrom stresse u krys.