Miokamycin and leukocyte activity in man.
The effects of miokamycin on the immune system were studied in healthy volunteers by means of the following assays: phagocytosis, intracellular killing and natural killer activity. The tests were performed before, 2 and 6 h after oral administration of 600 mg of miokamycin. The findings suggest that miokamycin stimulates phagocytosis and intracellular killing. These effects could be clearly shown 2 h after drug intake and disappeared at the 6th hour. On the contrary, the natural killer activity was not significantly stimulated by miokamycin.
Fraschini
F
F
Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
Scaglione
F
F
Ferrara
F
F
Dugnani
S
S
Falchi
M
M
Cattaneo
G
G
D000328:Adult; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects*; D007933:Leucomycins / Q000494:pharmacology*; D015644:Miocamycin; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*
D007933:Leucomycins; D015644:Miocamycin