Elimination of C-6-hydrogen during the formation of ecdysteroids from cholesterol in Locusta migratoria ovaries.
Being administered to Locusta migratoria adult females, [6-3H, 4-14C]cholesterol was incorporated into ecdysone and 2-deoxyecdysone. The ratio of 3H/14C of the two ecdysteroids isolated from newly laid eggs revealed that C-6-hydrogen of cholesterol was eliminated during the conversion to ecdysteroids in the ovaries of the insects. Thus, a hypothetical mechanism involving migration of the C-6-hydrogen to the C-5 position in the formation of A/B cis junction turned out to be less likely.
Fujimoto
Y
Y
Department of Chemistry, Tokyo Institute of Technology, Japan.
Hiramoto
M
M
Kakinuma
K
K
Ikekawa
N
N
D000818:Animals; D002250:Carbon Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D002784:Cholesterol / Q000378:metabolism*; D026461:Ecdysteroids; D004531:Eggs / Q000032:analysis; D005260:Female; D006110:Grasshoppers / Q000378:metabolism; D007447:Invertebrate Hormones; D010053:Ovary / Q000378:metabolism*; D014316:Tritium
D002250:Carbon Radioisotopes; D026461:Ecdysteroids; D007447:Invertebrate Hormones; D014316:Tritium; D002784:Cholesterol