Developmental differences of antinociceptive effects of oxotremorine in two inbred strains of mice.
During development the C57BL/6 and DBA/2 mouse strains present morphological variations in cholinergic forebrain structures correlated with different behavioral reactivities to cholinergic agents. The present research assessed that these strain-dependent differences are also present in cholinergic-mediated analgesia. The administration of oxotremorine (0.0025, 0.005 and 0.01 mg/kg) to 30- and 60-day-old C57 and DBA mice resulted in dose- age- and strain-dependent analgesia. In particular oxotremorine is more effective in DBA/2 than in C57BL/6 mice and the latter strain showed a significant decrease of analgesic response in adulthood.
Pavone
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Istituto di Psicobiologia e Psicofarmacologia, C.N.R., Rome, Italy.
Consorti
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Fagioli
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D000375:Aging / Q000378:metabolism* / Q000502:physiology; D000698:Analgesia; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains / Q000502:physiology*; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D010095:Oxotremorine / Q000494:pharmacology*; D010277:Parasympathomimetics / Q000494:pharmacology; D013045:Species Specificity
D010277:Parasympathomimetics; D010095:Oxotremorine