In vitro evidence for impaired cellular immune responsiveness in children with chronic renal failure.
We used mixed lymphocyte culture (MLC) as an assay to evaluate in vitro the cellular immune functions of children with chronic renal insufficiency (CRI) or with chronic renal failure (CRF). The proliferative response of lymphocytes from both groups of patients was significantly reduced as compared to the response of control individuals. In addition, the proliferative response of CRF patients treated with hemodialysis was significantly lower than the response of continuous ambulatorial peritoneal dialysis (CAPD) patients. These data confirm that a marked depression of the cellular immune response is detectable in a pediatric population, as predicted from data from the literature on the adult renal failure population.
Manca
F
F
Department of Immunology, XIII USL-University of Genoa, Italy.
Perfumo
F
F
Kunkl
A
A
Costantini
M
M
Gusmano
R
R
D002648:Child; D005919:Glomerular Filtration Rate; D006801:Humans; D007111:Immunity, Cellular; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000628:therapy; D008213:Lymphocyte Activation; D010530:Peritoneal Dialysis; D006435:Renal Dialysis; D013601:T-Lymphocytes / Q000276:immunology