title: Sustained and controlled release of neuroactive substances in the CNS by encapsulation into implantable polymers.
abstract: Implantable drug-polymer matrices have great potential as sources for drug administration into the CNS. Their size and release characteristics can be adjusted by design, they provide protection of the encapsulated drug from premature metabolism or inactivation, and they can provide long-term constant or modulated drug release into discrete regions of the brain. However, they may not prove useful for the administration of neuroactive substances which require adjustment or discontinuation of dosage.
authors: Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, NC 27858-4354.
authors: G M
authors: GM
authors: Peterson
mesh_terms: D001927:Brain Diseases / Q000188:drug therapy*; D002214:Capsules; D003692:Delayed-Action Preparations; D004343:Drug Implants; D006801:Humans; D011108:Polymers
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D004343:Drug Implants; D011108:Polymers