title: Hydrins, hydroosmotic neurohypophysial peptides: osmoregulatory adaptation in amphibians through vasotocin precursor processing.
abstract: From neurointermediate pituitary glands of Xenopus laevis and Rana esculenta, previously unreported peptides termed hydrins, active on water permeability of frog urinary bladder and frog skin (Brunn or "water-balance" effect), have been isolated and sequenced. These peptides seem to be derived from the pro-vasotocin-neurophysin precursor. Hydrin 1, found in Xenopus, has been identified as vasotocin C-terminally extended with the Gly-Lys-Arg sequence; hydrin 2, found in Rana, has been identified as vasotocin C-terminally extended with glycine. Hydrin 2 has been detected in several Ranidae (R. esculenta, Rana temporaria, Rana pipiens) and Bufonidae (Bufo bufo, Bufo ictericus) and appears to have a large distribution in terrestrial or semiaquatic anurans. Hydrins, in contrast to vasotocin, are not active on rat uterus or rat blood pressure. They are absent from other vasotocin-bearers such as birds and could be involved specifically in water-electrolyte regulation of amphibians.
authors: Laboratory of Biological Chemistry, University of Paris VI, France.
authors: Y
authors: Y
authors: Rouillé
authors: G
authors: G
authors: Michel
authors: M T
authors: MT
authors: Chauvet
authors: J
authors: J
authors: Chauvet
authors: R
authors: R
authors: Acher
mesh_terms: D000064:Acclimatization; D000595:Amino Acid Sequence; D000818:Animals; D008969:Molecular Sequence Data; D010121:Oxytocin / Q000031:analogs & derivatives / Q000235:genetics / Q000302:isolation & purification; D010904:Pituitary Gland, Posterior / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D011893:Rana esculenta; D013045:Species Specificity; D014668:Vasotocin / Q000031:analogs & derivatives* / Q000235:genetics* / Q000302:isolation & purification / Q000502:physiology; D014882:Water-Electrolyte Balance; D014982:Xenopus laevis
chemical_list: C060257:hydrin 1; C060258:hydrin 2; C001713:mesotocin; D010121:Oxytocin; D014668:Vasotocin