title: Diffuse osteosclerosis in hairy cell leukemia.
abstract: We describe two patients with a new clinical pathologic syndrome of diffuse osteosclerosis in association with hairy cell leukemia. In both patients bone marrow biopsies could not be obtained due to extremely hard bones and inability to insert the biopsy needle; neither patient had a history of bony pain or fracture. The osteosclerotic process in one patient stabilized after successful treatment of her hairy cell leukemia with interferon alpha and deoxycoformycin suggesting that the osteosclerosis observed was related to the underlying malignant disease. Possible etiologic mechanisms are discussed.
authors: Biological Response Modifiers Program, National Cancer Institute, Frederick, MD 21701.
authors: L A
authors: LA
authors: VanderMolen
authors: W J
authors: WJ
authors: Urba
authors: D L
authors: DL
authors: Longo
authors: J
authors: J
authors: Lawrence
authors: H
authors: H
authors: Gralnick
authors: R G
authors: RG
authors: Steis
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010026:Osteosclerosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography