title: Familial Crohn's disease in multiple siblings: no linkage to the HLA system.
abstract: We report five families with 3 or more children having Crohn's disease. In one family, 6 out of 11 siblings were affected. HLA haplotype study in affected children showed that the probability of random segregation was only 38 percent, making improbable a linkage between the histocompatibility locus and the development of Crohn's disease. However similar clinical patterns in siblings could suggest a genetic factor not linked to the HLA system.
authors: Clinique des Maladies de l'Appareil Digestif, CHU Lille, France.
authors: J F
authors: JF
authors: Colombel
authors: F
authors: F
authors: Guillemot
authors: A
authors: A
authors: Van Gossum
authors: F
authors: F
authors: Dufossé
authors: A
authors: A
authors: Cortot
authors: E
authors: E
authors: Dupont
authors: J C
authors: JC
authors: Paris
mesh_terms: D000293:Adolescent; D000328:Adult; D003424:Crohn Disease / Q000235:genetics*; D003627:Data Interpretation, Statistical; D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011336:Probability
chemical_list: D006680:HLA Antigens