Comment: mitochondrial genes and cancer.
As a result of an experimental confluence between carcinogenesis and oxidative phosphorylation, we published in 1971 'A Unitary Hypothesis for Carcinogenesis' [(1971) J. Antibiot. Tokyo 24, 405-417]. According to this hypothesis, damaged mitochondria release mitochondrial genetic material which like that from an oncogenic virus could enter the nuclear genome. Our original hypothesis and its justification cover the hypothesis recently presented by Dr C. Richter [(1988) FEBS Lett. 241, 1-5].
Hadler
H I
HI
Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, IL 62901.
D000375:Aging / Q000235:genetics*; D000818:Animals; D002273:Carcinogens; D004249:DNA Damage; D004272:DNA, Mitochondrial / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D010085:Oxidative Phosphorylation
D002273:Carcinogens; D004272:DNA, Mitochondrial