title: Release of platelet Met-enkephalin, but not serotonin, in migraine. A platelet response unique to migraine patients?
abstract: Plasma-induced release of platelet-serotonin and Met-enkephalin was studied by incubating platelets from migraineurs, tension headache patients and healthy volunteers with water, plasma collected during migraine attacks and with plasma collected during attack-free periods. Migraine-attack plasma, but not migraine attack-free plasma, released Met-enkephalin from platelets of migraineurs. Platelets of healthy controls or tension headache sufferers did not release their Met-enkephalin in response to either incubation medium. In contrast to Met-enkephalin, serotonin was not released from platelets in relevant quantities by migraine-attack plasma.
authors: Department of Neurology, University Hospital, Leiden, The Netherlands.
authors: M D
authors: MD
authors: Ferrari
authors: J
authors: J
authors: Odink
authors: M
authors: M
authors: Frölich
authors: C
authors: C
authors: Tapparelli
authors: J E
authors: JE
authors: Portielje
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood*; D012701:Serotonin / Q000097:blood*
chemical_list: D012701:Serotonin; D004744:Enkephalin, Methionine