Localization of breakpoints in the karyotype of workers professionally exposed to benzene.
Cytogenetic analysis was carried out on peripheral blood lymphocytes of 33 workers professionally exposed to benzene for 10-26 years. In the examined group structural chromosome aberrations were found in 147 metaphases (4.7%). Statistical analysis has shown that the distribution of breakpoints was not random. Chromosomes 2, 4 and 9 are almost twice as susceptible to breaks, while chromosomes 1 and 2 are almost twice as susceptible to gaps, as would be expected based on a random distribution of damage among chromosomes.
Sasiadek
M
M
Department of Pathophysiology, Medical Academy of Wrocław, Poland.
Jagielski
J
J
Smolik
R
R
D000328:Adult; D001554:Benzene / Q000633:toxicity*; D002869:Chromosome Aberrations; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects
D001554:Benzene