title: Recovery of rat mast cells after secretion: a morphometric study.
abstract: Granule reconstitution in rat peritoneal mast cells following massive secretion was studied by morphometric techniques. Immediately following secretion, the earliest identifiable mast cells showed a substantial decrease in cell volume associated with granule loss. Cell volume then increased almost to the original level over a period of a month. The size of the Golgi apparatus increased markedly in the week following secretion and then returned to its original size. The total volume of granules increased slowly after the secretory depletion and by 34 days had not returned to the original value although the number of granules had recovered fully. The reconstitution of mast cells after secretion is a prolonged process with several phases resulting in mast cells of varying appearance and content. This heterogeneity generated by reconstitution post secretion must be considered in studies of populations of mast cells in vivo.
authors: Department of Pathology, Sackler School of Medicine, Tel-Aviv University, Israel.
authors: I
authors: I
authors: Hammel
authors: D
authors: D
authors: Lagunoff
authors: P G
authors: PG
authors: Krüger
mesh_terms: D000818:Animals; D002642:Chick Embryo; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D008297:Male; D008407:Mast Cells / Q000166:cytology* / Q000378:metabolism / Q000648:ultrastructure; D008854:Microscopy, Electron; D015388:Organelles / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains