Practical management of NSAID gastropathy in rheumatic patients.
Gastropathy is a relatively common complication of treatment with a non-steroidal anti-inflammatory drug (NSAID). Pre-treatment evaluation of patients is therefore of key importance. Contraindications for NSAID treatment may include a history of gastroduodenal ulcer or of NSAID gastropathy, simultaneous administration of anticoagulant therapy and the existence of risk factors for ulcer disease. After NSAID treatment has begun, clinical follow-up is highly desirable. NSAID gastropathy can be asymptomatic despite the presence of a broad spectrum of gastrointestinal mucosal changes on endoscopy, but in the majority of cases there are clinical symptoms. Management of gastropathy may involve withdrawal of NSAID treatment, replacement therapy with a different type of drug or post hoc treatment of the gastropathy with anti-ulcer compounds.
Peltier
A P
AP
Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D005500:Follow-Up Studies; D005773:Gastroscopy; D006801:Humans; D012216:Rheumatic Diseases / Q000188:drug therapy*; D012307:Risk Factors; D013272:Stomach Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents