Parkinsonism secondary to bilateral striatal fungal abscesses.
A 24-year-old man with an 11-year history of i.v. drug use rapidly developed parkinsonism clinically indistinguishable from MPTP toxicity and Parkinson's disease. Although tests were negative for the human immunodeficiency virus, radiologic evaluation revealed bilateral striatal lesions. Stereotactic biopsy demonstrated septate hyphae consistent with either aspergillosis or mucormycosis. Gradual improvement followed systemic therapy with amphotericin B.
Adler
C H
CH
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia.
Stern
M B
MB
Brooks
M L
ML
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D001922:Brain Abscess / Q000150:complications* / Q000188:drug therapy; D001927:Brain Diseases / Q000150:complications / Q000188:drug therapy; D003342:Corpus Striatum; D006801:Humans; D008297:Male; D009181:Mycoses / Q000150:complications* / Q000188:drug therapy; D010302:Parkinson Disease, Secondary / Q000209:etiology*; D015819:Substance Abuse, Intravenous / Q000150:complications
D000666:Amphotericin B