title: Bronchial artery ligation modifies pulmonary edema after exposure to smoke with acrolein.
abstract: Pulmonary edema can follow smoke inhalation and is believed to be due to the multiple chemical toxins in smoke, not the heat. We have developed a synthetic smoke composed of aerosolized charcoal particles to which one toxin at a time can be added to determine whether it produces pulmonary edema. Acrolein, a common component of smoke, when added to the synthetic smoke, produced a delayed-onset pulmonary edema in dogs in which the extravascular lung water (EVLW) as detected by a double-indicator technique began to rise after 42 +/- 2 (SE) min from 148 +/- 16 to 376 +/- 60 ml at 165 min after smoke exposure. The resulting pulmonary edema was widespread macroscopically but appeared focal microscopically with fibrin deposits in alveoli adjacent to small bronchi and bronchioles. Bronchial vessels were markedly dilated and congested. Monastral blue B when injected intravenously leaked into the walls of the bronchial vessels down to the region of the small bronchioles (less than or equal to 0.5 mm ID) of acrolein-smoke-exposed dogs but not into the pulmonary vessels. Furthermore, ligation of the bronchial arteries delayed the onset of pulmonary edema (87 +/- 3 min, P less than 0.05) and lessened the magnitude (232 +/- 30 ml, P less than 0.05) at 166 +/- 3 min after acrolein-smoke exposure.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Department of Medicine (Pulmonary Unit), Massachusetts General Hospital, Harvard Medical School, Boston 02114.
authors: C A
authors: CA
authors: Hales
authors: P
authors: P
authors: Barkin
authors: W
authors: W
authors: Jung
authors: D
authors: D
authors: Quinn
authors: D
authors: D
authors: Lamborghini
authors: J
authors: J
authors: Burke
mesh_terms: D000171:Acrolein / Q000633:toxicity*; D000447:Aldehydes / Q000633:toxicity*; D000818:Animals; D001834:Body Water / Q000502:physiology; D001981:Bronchial Arteries / Q000503:physiopathology*; D004285:Dogs; D008026:Ligation; D011652:Pulmonary Circulation; D011654:Pulmonary Edema / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D015208:Smoke Inhalation Injury / Q000150:complications* / Q000473:pathology / Q000503:physiopathology
chemical_list: D000447:Aldehydes; D000171:Acrolein