title: Evidence of potential tumour-initiating and tumour-promoting activities of hickory smoke condensate when given alone or with nitrite to rats.
abstract: Epidemiological studies have indicated that the consumption of smoked fish and meat products is associated with an increased risk of stomach cancer. A commercial hickory smoke condensate (HSC) was evaluated for its tumour-initiating and promoting activities in the glandular stomach using short-term methods in vivo. HSC (1 ml of a 10-100% v/v solution/rat) was given orally, either with or without nitrite (25-100 mumols/rat) to male F344 rats. The potential of HSC to act as a glandular stomach carcinogen was revealed by the induction in the pyloric mucosa of the stomach of ornithine decarboxylase (ODC), replicative DNA synthesis (RDS) and DNA single-strand breaks. The administration of HSC with nitrite also induced unscheduled DNA synthesis in the pyloric mucosa, but led to decreased induction of ODC, RDS and DNA single-strand breaks in comparison with treatment with HSC alone. These results suggest that HSC contains substance(s) that have potential tumour-initiating and/or tumour-promoting activities and that reaction with nitrite generates new substance(s) that could act as potential tumour-initiators in the rat glandular stomach.
authors: Unit of Environmental Carcinogens and Host Factors, International Agency for Research on Cancer, Lyon, France.
authors: H
authors: H
authors: Ohshima
authors: C
authors: C
authors: Furihata
authors: T
authors: T
authors: Matsushima
authors: H
authors: H
authors: Bartsch
mesh_terms: D000818:Animals; D002273:Carcinogens; D003043:Cocarcinogenesis; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D005511:Food Handling; D005753:Gastric Mucosa / Q000201:enzymology; D008297:Male; D009573:Nitrites / Q000633:toxicity*; D009955:Ornithine Decarboxylase / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D012906:Smoke; D013274:Stomach Neoplasms / Q000139:chemically induced; D014934:Wood
chemical_list: D002273:Carcinogens; D009573:Nitrites; D012906:Smoke; D009955:Ornithine Decarboxylase