Comparison of different caloric substrates on intestinal adaptation in the rat.
We compared the relative efficacy of medium- and long-chain triglycerides and dextrose on intestinal adaptation. Parenterally nourished rats received an isocaloric luminal infusion of one of these three substrates for 1 wk into either the jejunum or the ileum. Intestinal mass (mucosal weight and protein content) as well as the in vivo absorption of 5 mM glucose, valine, and aspartic acid were measured. In the jejunum, long-chain triglycerides were the most trophic, whereas in the ileum, long-chain triglycerides and dextrose were equally effective, but significantly more trophic than medium-chain triglycerides. In general, absorptive function was better maintained by dextrose and medium-chain triglycerides than long-chain triglycerides in the jejunum or by dextrose in the ileum. These data demonstrate that the jejunum and ileum respond differently to caloric substrates. Medium-chain triglycerides do not appear to have a clear superiority to long-chain triglycerides or dextrose in producing intestinal adaptation.
Weinberg
L M
LM
Division of Gastroenterology and Nutrition, Albert Einstein Medical Center, Philadelphia, Pennsylvania.
Pusateri
J P
JP
Levine
G M
GM
D000222:Adaptation, Physiological; D000818:Animals; D001224:Aspartic Acid / Q000493:pharmacokinetics; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004041:Dietary Fats / Q000494:pharmacology*; D004655:Emulsions; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology; D005947:Glucose / Q000493:pharmacokinetics / Q000494:pharmacology; D006965:Hyperplasia / Q000503:physiopathology; D007082:Ileum / Q000473:pathology / Q000502:physiology*; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000473:pathology; D007583:Jejunum / Q000473:pathology / Q000502:physiology*; D008297:Male; D010743:Phospholipids; D051381:Rats; D011919:Rats, Inbred Strains; D013024:Soybean Oil; D014280:Triglycerides / Q000494:pharmacology; D014633:Valine / Q000493:pharmacokinetics
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D010743:Phospholipids; D014280:Triglycerides; C545823:soybean oil, phospholipid emulsion; D001224:Aspartic Acid; D013024:Soybean Oil; D014633:Valine; D005947:Glucose