Vasopressin reduces food intake in goats.
The effect of arginine vasopressin (VP) on cumulative food intake and meal pattern was tested in pygmy goats. VP injected intraperitoneally (I.P.) (0.75, 1.5 and 3.0 micrograms kg-1 body weight) appeared to reduce food intake in a dose-dependent manner by reducing the size of the first meal and by increasing the first intermeal interval (IMI). The hypophagic effect of VP was reversed by both a V1-receptor antagonist and an alpha-adrenergic antagonist. Exogenous VP (0.75 and 1.5 microgram kg-1 body weight I.P.) produced increases in plasma VP concentration which also may occur in stressful situations. VP might therefore be related to stress-induced anorexia.
Meyer
A H
AH
Institut für Veterinär-Physiologie, Universität Zürich, Switzerland.
Langhans
W
W
Scharrer
E
E
D000818:Animals; D001127:Arginine Vasopressin / Q000037:antagonists & inhibitors / Q000097:blood / Q000494:pharmacology*; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D004326:Drinking; D004435:Eating / Q000187:drug effects*; D005260:Female; D005502:Food; D006041:Goats; D007274:Injections, Intraperitoneal; D011863:Radioimmunoassay; D013997:Time Factors
D001127:Arginine Vasopressin