Kmeriol and other aromatic constituents of Kmeria duperreana.
The CHCl3-soluble fraction of a crude extract of Kmeria duperreana exhibited cytotoxic activity when tested in both KB and P388 tumor-cell cultures. Bioassay-directed fractionation led to the isolation of a cytotoxic alkaloid, liriodenine (1). Other constituents obtained from the extract included scopoletin (2), (-)-3,4,5-trimethoxyphenyl beta-D-glucopyranoside (3), (+)-syringaresinol beta-D-glucopyranoside (4), and a new phenylpropanol, kmeriol (5), whose chemical structure was established through spectroscopic analysis.
Dong
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Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60680.
Mondranondra
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Fong
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Farnsworth
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D000818:Animals; D000840:Anisoles; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D007941:Leukemia P388 / Q000473:pathology; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis*; D011409:Propylene Glycols / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000840:Anisoles; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D011409:Propylene Glycols; C061203:kmeriol