The 'well control' artefact in case/control studies of specific psychiatric disorders.
An appropriate choice of controls in case/control studies of specific psychiatric disorders is crucial for valid risk-factor assessment. One suggested approach to control-group selection, the use of a well control group, is the focus of this paper. While using well controls has intuitive appeal, this paper shows that such a procedure can lead to ambiguous and biased results.
Schwartz
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New York State Psychiatric Institute, Columbia University.
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D001008:Anxiety Disorders / Q000453:epidemiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008016:Life Change Events; D001523:Mental Disorders / Q000453:epidemiology* / Q000523:psychology; D012307:Risk Factors; D015983:Selection Bias; D014481:United States