Studies of the oxysterol inhibition of tumor cell growth.
The oxysterols 3 beta-hydroxy-5 alpha-cholest-8-en-11-one, 3 beta-hydroxy-5 alpha-cholest-8-en-7-one, 3 beta-hydroxy-5 alpha-cholest-8(14)-en-7-one, 3 beta-hydroxy-4,4'-dimethylcholest-5-ene-7 one, 4,4'-dimethylcholest-5-ene-3 beta, 7 alpha-diol, 4,4'-dimethylcholest-5-ene-3 beta, 7 beta-diol, lanost-8-ene-3 beta, 25-diol, 25-hydroxylanost-8-en-3-one, 9 alpha, 11 alpha-epoxy-5 alpha-cholest-7-en-3 beta-ol, 3 beta-hydroxycholest-5 alpha-en-22-one, and 3 beta-hydroxycholest-5-en-22-one oxime were evaluated with respect to their ability to inhibit cell growth. All of the sterols were found to possess cytotoxicity when incubated with hepatoma (HTC) and lymphoma (RDM-4) cells in culture at 10-30 microM concentrations.
Parish
E J
EJ
Department of Chemistry, Auburn University, AL 36849-5312.
Chitrakorn
S
S
Luu
B
B
Schmidt
G
G
Ourisson
G
G
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002783:Cholestenones; D004354:Drug Screening Assays, Antitumor; D006888:Hydroxycholesterols; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D051381:Rats; D013261:Sterols / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D002783:Cholestenones; D006888:Hydroxycholesterols; D013261:Sterols