Effects of hypertonic NaCl solution on the hamster cheek pouch microcirculation in normo- and hypovolemia.
The aim of this study was to evaluate the effects of a single, 10 min, intravenous infusion of a hypertonic NaCl solution [2400 mOsm/l; infused volume 0.35 +/- 0.03 ml (SEM)] on the hamster cheek pouch microcirculation during normovolemia and after acute bleeding to a hypotension level of about 40 mmHg. Upon bleeding, the arterial pressure dropped to 39 mu 1 mmHg, arterioles greater than 40 microns constricted 12 +/- 3% (from their control value), arterioles less than 40 microns dilated 6 +/- 2%, venules stayed largely unchanged, while RBC velocity and volume flow decreased 57 +/- 7% in all vessels. During the subsequent hypertonic NaCl infusion, the arterial pressure increased rapidly to a new steady state level of 66 +/- 3 mmHg. After the infusion, the large arterioles stayed constricted 11 +/- 1% and the small arterioles dilated 7 +/- 1% for a 1-h observation period. The venules constricted initially by 6 +/- 2% and returned to control diameter in 30-40 min. RBC velocity and calculated volume flow returned to the pre-hemorrhage control values in about 10 min for the arterioles and in 40 min for the venules. An identical hypertonic infusion given to normovolemic hamsters caused no significant alterations of the measured variables.
Bouskela
E
E
Department of Physiology and Biophysics, University of Lund, Sweden.
Grampp
W
W
Mellander
S
S
D000818:Animals; D001160:Arterioles / Q000187:drug effects; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects*; D002610:Cheek / Q000098:blood supply*; D006224:Cricetinae; D005260:Female; D007262:Infusions, Intravenous; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D012769:Shock / Q000503:physiopathology; D013997:Time Factors
D012462:Saline Solution, Hypertonic