Chlordane: thirty-month tumorigenicity and chronic toxicity test in rats.
Groups of 80 Fischer 344 specific-pathogen-free rats of each sex were fed 0, 1, 5, and 25 ppm chlordane for 130 weeks. The rats were examined for hematological, biochemical, urinary, and pathological changes at 26, 52, and 130 weeks of exposure. The original pathologist found statistically significant dose-related changes only in the liver. At 25 ppm chlordane in the diet there were increases in bilirubin levels, liver weight, liver cell volume (centered at the lobules), hepatic necrosis (only in animals found dead or killed in extremis), and hepatocellular nodules (only after 105 weeks of exposure). A peer review of the pathology for all tumors observed on test were spontaneous and unrelated to treatment. From the original pathologist the no-observed-effect level (NOEL) for chlordane in the diet of Fischer 344 rats was found to be 5 ppm. From the peer review data the NOEL in males is 25 ppm and in females is 1 ppm.
Khasawinah
A M
AM
Velsicol Chemical Corporation, Rosemont, Illinois 60018-5119.
Grutsch
J F
JF
D000818:Animals; D001835:Body Weight; D015197:Carcinogenicity Tests; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology; D002706:Chlordan / Q000633:toxicity*; D004435:Eating / Q000187:drug effects; D004798:Enzymes / Q000097:blood; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced; D008099:Liver / Q000187:drug effects; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000503:physiopathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D014481:United States; D014484:United States Environmental Protection Agency
D004798:Enzymes; D002706:Chlordan