UCHL1-positive extranodal lymphoma resembling multiple lymphomatous polyposis of the gastrointestinal tract.
Histopathologic and immunohistochemical studies were done on paraffin sections from a patient with alimentary tract lymphoma resembling multiple lymphomatous polyposis of the gastrointestinal tract (MLP). Diffuse, but not follicular, proliferation of medium-sized lymphoid cells was noted in the polypoid lesions of the alimentary tract, peripancreatic lymph nodes, spleen, liver, and bone marrow. These cells possessed a T-cell-related antigen (UCHL1), but were negative for the B-cell-related and myeloid cell-related antigens examined. Because neoplastic cells in MLP are usually of B-cell origin, the current case will provide important information on the relation between phenotypes and morphologic patterns of proliferation.
Nakamine
H
H
Department of Laboratory Medicine, Wakayama Medical School, Japan.
Sakamoto
H
H
Tanaka
T
T
Nakashima
N
N
Takenaka
T
T
Maeda
J
J
D000368:Aged; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D004067:Digestive System Neoplasms / Q000032:analysis / Q000473:pathology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000032:analysis / Q000473:pathology*; D008297:Male; D011127:Polyps / Q000473:pathology*; D013601:T-Lymphocytes / Q000032:analysis / Q000473:pathology
D000945:Antigens, Differentiation, T-Lymphocyte