[Changes in cerebrospinal fluid immunoglobulin serial parameters in neurologic disorders].
Cerebrospinal fluid (CSF) immunoglobulin serial parameters were determined with the method of single radial immunodiffusion (SRID) in 458 neurological cases with 30 kinds of diseases. The results were compared with the normal values from 36 subjects of comparable age. The authors considered that the elevated CSF-Ig could occur in the following 5 pathological processes: (1) Ig endogenous synthesis in the central nervous system (CNS). (2) inflammatory diffusion, which would be seen in general inflammation but the blood-brain-barrier (BBB) would be normal; (3) diffusion due to damaged BBB, including acute hemorrhagic and ischemic cerebrovascular diseases (4) inflammatory diffusion in combination with BBB impairment. (5) Ig endogenous synthesis in the CNS in combination with diffusion, due to damaged BBB as seen in Guillain-Barre syndrome and sporadic encephalitis. It was considered that in the CSF, IgG, IgA, IgM and C3 would show simultaneous corresponding increase or decrease in quite a number of neurological disorders.
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D001812:Blood-Brain Barrier; D002561:Cerebrovascular Disorders / Q000134:cerebrospinal fluid; D006801:Humans; D007070:Immunoglobulin A / Q000134:cerebrospinal fluid; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid*; D011129:Polyradiculoneuropathy / Q000134:cerebrospinal fluid
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M