The role of toxic oxygen metabolites in interleukin-2-induced vascular leak syndrome.
We demonstrated that IL-2 causes injury by a blood mediator not by a direct action on endothelial cells and that toxic oxygen metabolites may play a role.
Mulvin
D W
DW
Grosso
M A
MA
Kruse
C A
CA
Howard
R B
RB
Repine
J E
JE
Johnston
M R
MR
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D005609:Free Radicals; D006207:Half-Life; D007376:Interleukin-2 / Q000493:pharmacokinetics*; D010100:Oxygen / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D005609:Free Radicals; D007376:Interleukin-2; D010100:Oxygen