[The effect of cepharanthine on the hemopoietic suppression by X-ray irradiation--hematological and histological studies].
The effects of cepharanthine on the suppression of hemopoiesis by X-ray irradiation were studied. A whole body X-irradiation (3 Gy) induced decrease of leucocyte count, nucleated cell count of bone marrow, myeloid stem cell count (CFU-C), and spleen weight. Oral administration of cepharanthine (25 mg/kg BW or 50 mg/kg BW) tended to decrease these damage on hemopoiesis, and increased spleen weight on 5th day after irradiation. Histological examinations revealed that the administration of cepharanthine accelerated the hemopoietic recovery in the red pulp of spleen.
Mori
M
M
Kawasaki
S
S
Sacho
M
M
Awai
M
M
Sadahira
Y
Y
Ono
M
M
D000470:Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D044182:Benzylisoquinolines; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D002452:Cell Count / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects* / Q000473:pathology; D014965:X-Rays; D052117:Benzodioxoles
D000470:Alkaloids; D044182:Benzylisoquinolines; C006947:cepharanthine; D052117:Benzodioxoles