title: Management options for Propionibacterium acnes endophthalmitis.
abstract: The authors reviewed the management of nine culture-proven cases of Propionibacterium acnes endophthalmitis which presented at an average of 4 months after extracapsular cataract extraction (ECCE) and posterior chamber intraocular lens (PC IOL) implantation. The initial signs included a white intracapsular plaque (9/9), vitritis (9/9), granulomatous uveitis (4/9), nongranulomatous uveitis (5/9), hypopyon (4/9), beaded fibrin strands in the anterior chamber (3/9), and diffuse intraretinal hemorrhages (2/9). A variety of management schemes were used in these patients, including the following: topical and intravenous antibiotics alone; intraocular and topical antibiotic administration; pars plana vitrectomy with capsulectomy and intraocular antibiotic administration; and removal of all capsular remnants with PC IOL removal or exchange. The final visual acuities ranged from 20/20 to 20/60 in six eyes and 20/200 to 20/400 in three eyes. This review suggests that a variety of management options for P. acnes endophthalmitis appear to be successful. Based on the authors' experience, an algorithm for future treatment is offered.
authors: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33136.
authors: W
authors: W
authors: Zambrano
authors: H W
authors: HW
authors: Flynn
authors: S C
authors: SC
authors: Pflugfelder
authors: T J
authors: TJ
authors: Roussel
authors: W W
authors: WW
authors: Culbertson
authors: S
authors: S
authors: Holland
authors: D
authors: D
authors: Miller
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000628:therapy*; D002387:Cataract Extraction; D004333:Drug Administration Routes; D009877:Endophthalmitis / Q000628:therapy*; D005260:Female; D006801:Humans; D007910:Lenses, Intraocular; D008297:Male; D011379:Prognosis; D011425:Propionibacterium acnes / Q000187:drug effects; D012189:Retrospective Studies; D014792:Visual Acuity; D014821:Vitrectomy
chemical_list: D000900:Anti-Bacterial Agents