title: [Effect of digoxin on sinoatrial node automatism and atrio-ventricular conductivity in patients with a paroxysmal form of atrial fibrillation].
abstract: Digoxin was studied for its effects on the function of sinus nodal automatism and atrioventricular conduction in an acute experiment and during a course therapy. Digoxin was shown to exert substantial effects on the sinus node with its retained function and dysfunction. When digoxin was given in a daily dose of 0.375 mg, there was an increase in sinoatrial conduction time. When the drug was administered in a single dose of 0.4 mg, there was no substantial change in the atrioventricular conduction. During its course therapy, digoxin failed to produce antirecurrent antiarrhythmic effects.
authors: V A
authors: VA
authors: Bobrov
authors: Iu B
authors: IuB
authors: Shchepotin
authors: A
authors: A
authors: Sui'lkhi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000503:physiopathology; D001283:Atrioventricular Node / Q000187:drug effects* / Q000503:physiopathology; D004077:Digoxin / Q000627:therapeutic use*; D005260:Female; D006329:Heart Conduction System; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012849:Sinoatrial Node / Q000187:drug effects* / Q000503:physiopathology
chemical_list: D004077:Digoxin
vernacular_title: Vliianie digoksina na funktsiiu avtomatizma sinusovogo uzla i atrioventrikuliarnuiu provodimos't u bo'lnykhs paroksizma'l- noĭ formoĭ fibrilliatsii predserdiĭ.