[Effect of low-molecular toxic substances on the organs of the immune system in mothers and their offspring].
Administration of benzpirene to the mother is accompanied with activation of B-and decrease in T-links of immune activity both in the mother and offspring. The lymphoid organs in the animals, not subjected antenatally to benziprene action, but given the substance after birth, undergo destabilization and are not ready to administration of this polycyclic hydrocarbonic compound. This produces their hypoplasia. It is quite possible, that under this condition the activity of the cellular link of immunity decreases, and the humoral one is stimulated. Certain morphofunctional connections are supposed to exist between the immune systems of the mother and the fetus. The antenatal action of benzpirene causes a responsive reaction in the offspring as an immunological commemoration, and it ensures the level of the immune response.
Borodin
Iu I
IuI
Sklianova
N A
NA
Ivanov
V V
VV
Sklianov
Iu I
IuI
Semeniuk
A V
AV
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D001580:Benzopyrenes / Q000494:pharmacology / Q000633:toxicity*; D005260:Female; D006984:Hypertrophy; D007112:Immunity, Maternally-Acquired / Q000187:drug effects*; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D008297:Male; D008970:Molecular Weight; D011247:Pregnancy; D051381:Rats
D001580:Benzopyrenes
Vliianie nizkomolekuliarnykh toksikantov na organy immuniteta materi i potomstva.