[Immunoscintigraphy of choroid melanoma using monoclonal antibodies].
A prospective pilot study on immunoscintigraphy with monoclonal antibody fragments against cutaneous melanoma (MoAb 225.28S) was performed in 17 patients with a clinical diagnosis of choroidal melanoma. Monoclonal antibodies against melanoma associated antigen were labelled with 740 mBq (20 MCi) of the radionuclide 99mTc and injected intravenously. Images were made with a gamma camera 6 hours after injection. With a double pinhole collimator radioactivity was counted thrice in both eyes 6 hours after injection. In 6 out of 17 patients (35.3%) the melanoma could be imaged with the gamma camera. With the double pinhole collimator a significantly higher activity was measured in the melanomatous eye in 13 out of 17 patients (76.5%). In four patients a false negative result was obtained. Considering these results immunoscintigraphy may be valuable in ocular melanoma diagnostics but its specific value still has to be assessed.
Schaling
D F
DF
van Kroonenburgh
M J
MJ
Borsje
R A
RA
Kakebeeke-Kemme
H M
HM
Oosterhuis
J A
JA
Pauwels
E K
EK
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D002830:Choroid Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000175:diagnosis*; D008875:Middle Aged; D011446:Prospective Studies
D000911:Antibodies, Monoclonal
Immunoscintigrafie van het choroideamelanoom met behulp van monoklonale antilichamen.