A conservative viewpoint on linkage in Alzheimer's disease.
Linkage data in Alzheimer's disease have not firmly established a genetic locus on chromosome 21 in early onset disease families. There is little or no support for a chromosome 21 locus in late onset families. Differences in the selection of families and the analysis of data accounts for the differences in interpretation. The actual location of a genetic locus (or loci) for Alzheimer's disease in the human genome will not be influenced by this controversy; more data from exclusion mapping and the use of several methods of linkage analysis will answer current questions.
Roses
A D
AD
Division of Neurology, Duke University Medical Center, Durham, NC 27710.
D000544:Alzheimer Disease / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21; D008040:Genetic Linkage; D006801:Humans