[Dynamic tests for calcium-regulating hormones in childhood. Evaluation of the incremental response in normal subjects].
Some tests to study the dynamic secretion of calcium-regulating hormones in childhood are presented. A low-calcium diet (less than or equal to 2 mg/kg/daily) for 1,25-dihydroxyvitamin D [1.25-(OH)-2D], ASU-eel-CT i.m. injection (80 U MRC/1.73 mq) for parathyroid hormone (PTH), and calcium infusion (2 mg/kg in 5') for calcitonin (CT) are employed. A significant increase in 1,25-(OH)-2D level (1 degree day: 47.0 +/- 6.7 pg/ml; 3 degree day: 73.2 +/- 6.9 pg/ml; p less than 0.001; n = 19), intact PTH values (basal: 29.7 +/- 7.5 pg/ml; +120': 68.2 +/- 7.8 pg/ml; p less than 0.001; n = 10) and monomeric CT concentrations (basal: 5.2 +/- 2.3 pg/ml; +10': 26.2 +/- 4.4 pg/ml; p less than 0.001; n = 18) have been observed. The employed tests are able to show a significant increase in calcium-regulating hormones in healthy children. These tests are a simple and reliable method without side-effects that may provide further information on the pathogenesis of some pediatric diseases with altered mineral homeostasis.
Saggese
G
G
Bertelloni
S
S
Baroncelli
G I
GI
Buggiani
B
B
Gualtieri
M
M
Fusaro
C
C
D000293:Adolescent; D002116:Calcitonin / Q000378:metabolism* / Q000502:physiology; D002117:Calcitriol / Q000378:metabolism* / Q000502:physiology; D002118:Calcium / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000378:metabolism* / Q000502:physiology
D010281:Parathyroid Hormone; D002116:Calcitonin; D002117:Calcitriol; D002118:Calcium
Tests dinamici per gli ormoni calciotropi in età pediatrica. Valutazione della risposta incretoria in soggetti normali.