title: Erythrocyte destruction under periodically fluctuating shear rate: comparative study with constant shear rate.
abstract: The hydrodynamic effect of periodically fluctuating shear rate on erythrocyte destruction was quantitatively studied in vitro in comparison with constant shear rates. Uniform shear rates (less than 1,000 s-1; constant or sinusoidally fluctuating with time) were applied to heparinized canine blood contained in the concavo-convex type of Couette flow testing machine for (1.8-9.0) x 10(3) s at 24 degrees C. The results show that the erythrocyte destruction (evaluated with hemolysis ratio; plasma hemoglobin count per whole blood hemoglobin count) decreases when the exposure time of larger (greater than 500 s-1) shear rates is interspersed with smaller (less than 300 s-1) shear rates.
authors: School of Medicine, Kitasato University, Sagamihara, Japan.
authors: S
authors: S
authors: Hashimoto
mesh_terms: D004912:Erythrocytes / Q000032:analysis*; D006454:Hemoglobins / Q000032:analysis*; D006461:Hemolysis; D066298:In Vitro Techniques; D012212:Rheology; D013997:Time Factors
chemical_list: D006454:Hemoglobins