Stimulation of growth of human breast cancer cell lines in culture by linoleic acid.
Linoleic acid, an omega-6 unsaturated fatty acid, stimulated growth of the MDA-MB-231 and MCF-7 human breast cancer cell lines in culture. Responses of the estrogen-independent MDA-MB-231 cells both in serum-free medium and with 1% fetal bovine serum added were positively correlated with linoleic acid concentration over the entire range examined (5-750 ng/ml). Growth stimulation of the estrogen-responsive MCF-7 cell line was maximal at a LA concentration of 500 ng/ml when cultured in 1% fetal bovine serum-containing medium with added estradiol. Linoleic acid had no mitogenic effect on three human cancer cell lines derived from sites other than breast, or on untransformed 3T3 cells.
Rose
D P
DP
Division of Nutrition and Endocrinology, American Health Foundation, Valhalla, New York 10595.
Connolly
J M
JM
D001943:Breast Neoplasms / Q000473:pathology*; D002273:Carcinogens; D004041:Dietary Fats / Q000009:adverse effects*; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000633:toxicity*; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D002273:Carcinogens; D004041:Dietary Fats; D008041:Linoleic Acids; D019787:Linoleic Acid