The "public" determinants HLA-Bw4/Bw6 do not generate cytotoxic T lymphocytes (CTLs).
The human leucocyte antigens (HLA)-Bw4/Bw6 antigens detected serologically are "public" determinants located in the HLA-B molecule. They do not generate cytotoxic T lymphocytes (CTLs) in primary allogeneic cultures (mixed lymphocyte antigens) and secondary (primed lymphocyte typing) cultures indicate that they do not behave like normal HLA "private" cell-mediated lympholysis determinants. Therefore, the contribution of the 79-83 (alpha 1) residues in the generation of the epitopes Bw4/Bw6 does not seem to be critical for the examination by T cell receptor in allogeneic CML. The different overlapping patterns of the serological and CTL examinations are discussed, based on the structure of HLA class I antigens.
López-Larrea
C
C
Immunologia Hospital N.S. de Covadonga, Oviedo, Spain.
Arnaiz-Villena
A
A
D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D015235:HLA-B Antigens / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D013602:T-Lymphocytes, Cytotoxic
D015235:HLA-B Antigens