High chlorpromazine doses and liver function.
The aim of the present study was to evaluate the in vivo effect of high chlorpromazine (CPZ) doses on hepatocellular function. Thirty male Wistar rats weighing 200 to 250 g were divided into two groups: control (C, N = 17), injected ip with saline, and CPZ (N = 13), injected ip with high chlorpromazine doses (initial dose of 30 mg/kg body weight followed by daily doses of 10 mg/kg for 7 days). No significant differences in serum levels of alanine-aminotransferase, alkaline phosphatase and bilirubin or in mitochondrial function (activated and basal respiration and mitochondrial respiration control (activated/basal ratio) were detected between the two groups.
Castro-e-Silva Júnior
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O
Departmento de Cirurgia, Faculdade de Medicina de Ribeirão Pretro, Universidade de São Paulo, Brasil.
Ceneviva
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Roselino
J E
JE
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001663:Bilirubin / Q000097:blood; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014021:Tissue Preservation
D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin; D002746:Chlorpromazine