title: Fiberoptic endoscopic examination and biopsy in determining the extent of nasopharyngeal carcinoma.
abstract: This is a prospective study on the use of flexible endoscope and multiple biopsies in the assessment of nasopharyngeal carcinoma in 72 patients. This study confirmed the presence of submucosal growth pattern in nasopharyngeal carcinoma in 72 patients. This study confirmed the presence of submucosal growth pattern in nasopharyngeal carcinoma and this occurred in 13.8% of patients. Occult microscopic extension of tumor not detectable by fiberoptic endoscopy occurred in another 51.4% of patients. It has also been shown that multiple biopsy is superior to clinical examination in evaluating the extent of disease in nasopharyngeal carcinoma. Multiple biopsies are suggested for the early detection of nasopharyngeal carcinoma in high-risk cases. Although the better-defined tumor extent do not currently influence the treatment policy of nasopharyngeal carcinoma, and it is too early to assess its prognostic significance, it betters our understanding of the behavior of this tumor. Future analysis in correlation with long-term follow-up data may help to improve the stage classification systems and treatment strategy.
authors: Department of Radiotherapy and Oncology, Queen Mary Hospital, Pokfulam, Hong Kong.
authors: J S
authors: JS
authors: Sham
authors: W I
authors: WI
authors: Wei
authors: W H
authors: WH
authors: Kwan
authors: C W
authors: CW
authors: Chan
authors: P H
authors: PH
authors: Choi
authors: D
authors: D
authors: Choy
mesh_terms: D001706:Biopsy; D002277:Carcinoma / Q000473:pathology*; D004724:Endoscopy; D005189:False Positive Reactions; D005336:Fiber Optic Technology; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000473:pathology*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011446:Prospective Studies