Both single-dose and repeated administration of clomipramine reduces the behavioural response to intrathecal capsaicin in mice.
Capsaicin injected intrathecally releases substance P from primary sensory nerve endings, and induces a pain related behaviour in mice consisting of licking, biting and scratching directed to the distal part of the body. This behavioural response was reduced by approximately 35% after intraperitoneal administration of clomipramine, 10 mg/kg, 1 hr in advance, and by 38% after repeated administration (10 mg/kg/day for 9 days). Twenty-four hr after the last repeated clomipramine injection, the response after capsaicin was still reduced by 36%, indicating a long-lasting effect of repeated treatment. The results indicate that clomipramine has analgesic properties against pain of central origin both after single-dose and repeated administration.
Rosland
J H
JH
Department of Physiology, University of Bergen, Norway.
Hunskaar
S
S
Hole
K
K
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002211:Capsaicin / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D002997:Clomipramine / Q000494:pharmacology*; D007278:Injections, Spinal; D008297:Male; D051379:Mice; D009619:Nociceptors / Q000187:drug effects
D002997:Clomipramine; D002211:Capsaicin