Utility of the affected sib pair method to detect linkage of a sex-linked dominant disease with a sex-linked recessive trait.
Use of affected sib-pairs for linkage determination of a sex-linked dominant disease with a recessive X-chromosome marker will require extremely large sample sizes, particularly when the marker is marginally polymorphic. In addition, this method should not be used without caution on data collected for a traditional LOD score analysis, without considering the parental mating types involved in the informative families. Nevertheless, ascertainment adjustment and correction for dependence of multiple pairs of affected sib-pairs in families suggests that this method provides linkage inference concordant with that of the traditional LOD score analysis.
Chakraborty
R
R
Center for Demographic and Population Genetics, University of Texas Graduate School of Biomedical Sciences, Houston 77225.
D003117:Color Vision Defects / Q000235:genetics; D003198:Computer Simulation; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D010641:Phenotype; D011995:Recombination, Genetic