Cytochrome P-450 mediated metabolism in active murine systemic lupus erythematosus.
In a comparison of NZB/NZW female mice either with active systemic lupus erythematosus (SLE) (28-33 weeks of age) or without overt SLE (7-13 weeks), the hepatic microsomal activities of ethoxycoumarin O-deethylation and aminopyrine N-demethylation were decreased 32% (p less than 0.05) and 28% (p less than 0.03), respectively, and cytochrome P-450 levels were decreased 34% (p less than 0.01) in the mice with active SLE. These changes were not associated with age differences alone in 2 nonautoimmune strains. Active murine SLE is thus associated with significant depressions in both hepatic cytochrome P-450 levels and microsomal enzyme activities. The metabolism of drugs and endogenous substrates may thus be impaired in active SLE.
Baer
A N
AN
Department of Medicine, State University of New York, Buffalo.
Green
F A
FA
D015660:7-Alkoxycoumarin O-Dealkylase; D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D019363:Cytochrome P-450 CYP1A1; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004247:DNA / Q000276:immunology; D005260:Female; D008181:Lupus Nephritis / Q000201:enzymology* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008814:Mice, Inbred NZB; D008862:Microsomes, Liver / Q000201:enzymology / Q000276:immunology; D010105:Oxygenases / Q000378:metabolism*; D013250:Steroid Hydroxylases / Q000378:metabolism*
D000974:Antibodies, Antinuclear; D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D013250:Steroid Hydroxylases; D015660:7-Alkoxycoumarin O-Dealkylase; D019363:Cytochrome P-450 CYP1A1; C020120:estrogen 2-hydroxylase; D000633:Aminopyrine N-Demethylase