[Effect of ethanol on the morphological characteristics of the cerebral cortex in tissue culture].
Light and electron microscopy were used to study the effects of different ethanol concentrations (0.5 and 1%) on the organotypic culture of neonatal rat cerebral cortex. Ethanol produced a biphasic effect. Primarily, the adaptive response of the tissue increased and cell differentiation accelerated. Later, destruction signs accumulated. These changes correlated with the strength and duration of the stimulus. Exposure to 1% ethanol induced the destruction.
Me'lnikova
T N
TN
Konovalov
G V
GV
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity*; D009044:Motor Cortex / Q000187:drug effects* / Q000473:pathology; D009924:Organ Culture Techniques; D051381:Rats; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000473:pathology; D013268:Stimulation, Chemical; D013997:Time Factors
D003470:Culture Media; D000431:Ethanol
Vliianie étanola na morfologicheskuiu kharakteristiku ku'ltury kory golovnogo mozga.