Effect of one month of lactitol treatment on calcium metabolism in man.
The chronic use of lactitol as a food additive or laxative might adversely affect calcium homeostasis. Its effect on calcium metabolism has been examined in an open cross-over study in 12 volunteers given 20-40 g lactitol per day for one month. Compared to a control period without lactitol, the disaccharide did not alter the urinary excretion of calcium, inorganic phosphate or hydroxyproline, nor did it alter the circulating levels of calcium, phosphate, alkaline phosphatase, parathormone and osteocalcin. Chronic treatment with lactitol in laxative doses had no measurable effect on calcium metabolism in man.
Egger
B
B
Department of Clinical Pharmacology, University of Berne, Switzerland.
Arnera
V
V
Llull
J B
JB
Lauterburg
B H
BH
D000328:Adult; D002118:Calcium / Q000378:metabolism* / Q000652:urine; D003404:Creatinine / Q000097:blood; D004032:Diet; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood / Q000652:urine; D011897:Random Allocation; D013402:Sugar Alcohols / Q000494:pharmacology*
D010281:Parathyroid Hormone; D010710:Phosphates; D013402:Sugar Alcohols; D015675:Osteocalcin; D003404:Creatinine; C014635:lactitol; D006909:Hydroxyproline; D002118:Calcium