Early effect of the anticancer drug biocarbazin (DTIC synonym) on mice spermatogenesis.
Biocarbazin (DTIC synonym) is an anticancer drug acting as a purine analogue, as an alkylating agent, as a SH-group blocker. Biocarbazin administration in doses 50 and 200 mg/kg of body weight to adult male BALB/c mice suppresses the process of spermatogenesis. Seminiferous tubule of the testis displayed dose-dependent histological alterations manifested with decrease of mitotically dividing cells and increase in the number of multinucleated spermatocytes and spermatids. RNA synthetic activity studied by means of autoradiography showed a tendency for a reduction in the spermatogonia and pachytene spermatocytes.
Martinova
Y S
YS
Nikolova
D B
DB
Michova
Z
Z
D000818:Animals; D003606:Dacarbazine / Q000633:toxicity*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012671:Seminiferous Tubules / Q000187:drug effects*; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects*
D003606:Dacarbazine