Arthritis associated with adjuvant mycobacterial treatment for carcinoma of the bladder.
A patient who developed an inflammatory polyarthritis following intravesical administration of bacillus Calmette-Guérin (BCG) used in the treatment of bladder cancer is described. An inflammatory synovitis comprising predominantly T lymphocytes was demonstrated on synovial biopsy. The synovitis resolved spontaneously within 14 days in this 'human model' of adjuvant arthritis.
Hughes
R A
RA
Department of Immunology of Rheumatic Disease, Charing Cross Hospital, London.
Allard
S A
SA
Maini
R N
RN
D000283:Administration, Intravesical; D000368:Aged; D000369:Aged, 80 and over; D001168:Arthritis / Q000209:etiology* / Q000473:pathology; D001169:Arthritis, Experimental / Q000209:etiology; D001500:BCG Vaccine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D013582:Synovial Fluid / Q000166:cytology; D013585:Synovitis / Q000209:etiology / Q000473:pathology; D013601:T-Lymphocytes; D001749:Urinary Bladder Neoplasms / Q000628:therapy*
D001500:BCG Vaccine