title: Effect of systolic flow rate on the prediction of effective prosthetic valve orifice area.
abstract: The Gorlin equation for the hemodynamic assessment of valve area is commonly used in cardiac catheterization laboratories. A study was performed to test the prediction capabilities of the Gorlin formula as well as the Aaslid and Gabbay formula for the effective orifice area of prosthetic heart valves. Pressure gradient, flow, and valve opening area measurements were performed on four 27 mm valve prostheses (two mechanical bileaflet designs, St. Jude and Edwards-Duromedics, an Edwards pericardial tissue valve, and a trileaflet polyurethane valve) each mounted in the aortic position of an in vitro pulse duplicator. With the known valve orifice area, a different discharge coefficient was computed for each of the four valves and three orifice area formulas. After some theoretical considerations, it was proposed that the discharge coefficient would be a function of the flow rate through the valve. All discharge coefficients were observed to increase with increasing systolic flow rate. An empirical relationship of discharge coefficient as a linear function of systolic flow rate was determined through a regression analysis, with a different relationship for each valve and each orifice area formula. Using this relationship in the orifice area formulas improved the accuracy of the prediction of the effective orifice area with all three formulas performing equally well.
authors: Department of Biomedical Engineering, University of Iowa, Iowa City.
authors: R
authors: R
authors: Schoephoerster
authors: K B
authors: KB
authors: Chandran
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D002302:Cardiac Output; D006339:Heart Rate; D006350:Heart Valve Prosthesis; D006801:Humans; D008955:Models, Cardiovascular; D011140:Polyurethanes; D011336:Probability; D011474:Prosthesis Design; D013499:Surface Properties; D013599:Systole
chemical_list: D011140:Polyurethanes