title: Serum concentrations of alkaline phosphatase isoenzymes and osteocalcin in normal pregnancy.
abstract: We measured serum alkaline phosphatase isoenzymes and osteocalcin levels in 40 healthy women at 4-week intervals throughout uncomplicated pregnancies and 6 weeks after delivery in 17 women. Serum bone alkaline phosphatase was significantly higher in the third trimester than in early pregnancy (P less than 0.001), and this elevation was still apparent at the end of the puerperium, suggesting increased bone turnover. Serum osteocalcin was not detected (less than 0.2 micrograms/L) after the first trimester in the majority of women, and it reappeared within 48 h after delivery. The disappearance of osteocalcin after the first trimester and its rapid reappearance after delivery suggest placental clearance of this peptide. We conclude that serum osteocalcin measurements cannot be used as a marker of bone metabolism during pregnancy.
authors: Department of Obstetrics, Guy's Hospital, London, England.
authors: A
authors: A
authors: Rodin
authors: A
authors: A
authors: Duncan
authors: H W
authors: HW
authors: Quartero
authors: G
authors: G
authors: Pistofidis
authors: G
authors: G
authors: Mashiter
authors: K
authors: K
authors: Whitaker
authors: D
authors: D
authors: Crook
authors: J C
authors: JC
authors: Stevenson
authors: M G
authors: MG
authors: Chapman
authors: I
authors: I
authors: Fogelman
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood*; D001842:Bone and Bones / Q000201:enzymology; D002135:Calcium-Binding Proteins / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008099:Liver / Q000201:enzymology; D015675:Osteocalcin; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy / Q000097:blood*; D013997:Time Factors
chemical_list: D002135:Calcium-Binding Proteins; D007527:Isoenzymes; D015675:Osteocalcin; D000469:Alkaline Phosphatase