title: Substrate-affinity relationship of succinate dehydrogenase in brain of albino rat during dieldrin toxicity.
abstract: Substrate kinetics of succinate dehydrogenase (EC 1.3.99.1) were studied in the brain of control and dieldrin-treated albino rats. Dieldrin inhibited the enzyme activity to various degrees and also altered the Michaelis-Menten constant (Km) of the enzyme. Activation energy values (delta E) were increased, suggesting decreased maximal velocity Vmax, and the high Km obtained for the enzyme also revealed decreased enzyme-substrate affinity and masking of active sites by dieldrin.
authors: Department of Zoology, S.V. University, India.
authors: G R
authors: GR
authors: Reddy
authors: G R
authors: GR
authors: Babu
authors: P
authors: P
authors: Reddanna
authors: C S
authors: CS
authors: Chetty
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology*; D004026:Dieldrin / Q000633:toxicity*; D004734:Energy Metabolism; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D013385:Succinate Dehydrogenase; D004026:Dieldrin