Bladder cancer and occupational exposure to polycyclic aromatic hydrocarbons.
The association between occupational exposure to polycyclic aromatic hydrocarbons (PAH) and bladder cancer development was investigated in a population-based case-control study carried out in the Bormida valley, Italy. One hundred and twenty-one male cases and 342 male controls, matched age, were collected from local hospitals. Occupational exposure to PAH and aromatic amines (AA) was evaluated by means of a job exposure matrix, constructed specifically for this study. Subjects considered as sharing a "definite exposure to PAH" showed an increased risk even after adjustment for cigarette smoking and exposure to AA (OR = 2.14, 95% CL 0.82-5.60). No elevation in risk was found for the category "possible exposure to PAH" (OR = 1.05, 95% CL 0.45-2.44). The findings of this study are consistent with previous studies indicating PAH as a risk factor for bladder cancer. A possible residual confounding effect due to AA impurities is discussed.
Bonassi
S
S
Servizio di Epidemiologia Ambientale, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
Merlo
F
F
Pearce
N
N
Puntoni
R
R
D016022:Case-Control Studies; D002617:Chemical Industry; D006801:Humans; D007407:Interviews as Topic; D007558:Italy / Q000453:epidemiology; D016013:Likelihood Functions; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced* / Q000453:epidemiology; D009790:Occupations; D011083:Polycyclic Compounds / Q000009:adverse effects*; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000453:epidemiology
D011083:Polycyclic Compounds