A new immunomodulator, FR-901235.
FR-901235 is a new type of immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. The mitogen-induced lymphocyte proliferation which had been suppressed by addition of immunosuppressive factor, was restored to a normal level by the addition of FR-901235. Furthermore, the subsequent administration of FR-901235 partially restored the impaired delayed-type hypersensitivity to sheep red blood cells in tumor-bearing mice.
Shibata
T
T
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Nishikawa
M
M
Tsurumi
Y
Y
Takase
S
S
Terano
H
H
Kohsaka
M
M
D000276:Adjuvants, Immunologic / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D043803:Phenalenes; D011083:Polycyclic Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects
D000276:Adjuvants, Immunologic; D043803:Phenalenes; D011083:Polycyclic Compounds; C061219:FR 901235