title: Positron emission tomographical studies of 1-11C-acetoacetate, 2-18F-fluoro-deoxy-D-glucose, and L-1-11C-tyrosine uptake by cat brain with an experimental lesion.
abstract: In cat brain with a freezing injury, the uptake of 1-11C-acetoacetate (11C-ACAC), 2-18F-fluorodeoxy-D-glucose (18FDG), and L-1-11C-tyrosine (11C-TYR) was monitored by positron emission tomography following intravenous administration of the tracers, at 1 day, and 1-3 weeks after the injury. The development and further course of the cold-induced oedema was monitored by magnetic resonance imaging. In the fresh (1 day old) lesion there was increased uptake of 11C-ACAC, probably due to release of the restrictive influence of the blood-brain barrier upon passage of the substance into brain. The uptake of 18FDG, which normally occurs by carrier-mediated transport at the barrier, was decreased in the fresh lesion, probably as a result of damage of the carrier mechanism. In the 3 week old lesion 18FDG uptake was still reduced, and 11C-ACAC uptake was still increased, although barrier function to Evans blue had recovered. It is suggested, that the increased 11C-ACAC uptake in the chronic lesion bears upon the proliferation of macrophages and reactive glial cells in the lesion. This is supported by the increased uptake of 11C-TYR in the 2 weeks old lesion, while in the fresh lesion 11C-TYR uptake was unchanged.
authors: Department of Neurosurgery, University of Groningen, The Netherlands.
authors: G H
authors: GH
authors: Prenen
authors: K G
authors: KG
authors: Go
authors: A M
authors: AM
authors: Paans
authors: F
authors: F
authors: Zuiderveen
authors: W
authors: W
authors: Vaalburg
authors: R L
authors: RL
authors: Kamman
authors: W M
authors: WM
authors: Molenaar
authors: S
authors: S
authors: Zijlstra
authors: P H
authors: PH
authors: Elsinga
authors: J B
authors: JB
authors: Sebens
mesh_terms: D000090:Acetoacetates; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001812:Blood-Brain Barrier; D001921:Brain / Q000000981:diagnostic imaging; D001929:Brain Edema / Q000000981:diagnostic imaging*; D001930:Brain Injuries / Q000000981:diagnostic imaging*; D002545:Brain Ischemia / Q000000981:diagnostic imaging; D002250:Carbon Radioisotopes; D002415:Cats; D002560:Cerebrovascular Circulation; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005615:Freezing; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010296:Parietal Lobe / Q000293:injuries; D014055:Tomography, Emission-Computed; D014443:Tyrosine
chemical_list: D000090:Acetoacetates; D001786:Blood Glucose; D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D009419:Nerve Tissue Proteins; D019788:Fluorodeoxyglucose F18; D014443:Tyrosine; C016635:acetoacetic acid; D003847:Deoxyglucose