Effect of D-galactosamine on blood clearance of 99mTc-phytate in rats.
The effect of D-galactosamine (GalN) on the blood clearance of 99mTc-phytate (99mTc-P) in rats was examined, and the blood clearance test of 99mTc-P was compared with the cases of serum transaminase and bilirubin test. Serum transaminase and bilirubin levels in rats increased dose-dependantly after GalN administration. The disappearance rate of 99mTc-P from blood decreased with the increase in dose of GalN and with the passage of time after the GalN administration. Changes of the blood clearance of 99mTc-P after GalN treatment in rats may be influenced by the disorder in the hepatocytes and the alteration of the liver reticuloendothelial system phagocytic function. The blood clearance test of 99mTc-P in rats showed a sensitive reaction for the acute hepatic dysfunction induced by GalN equally to or higher than the serum transaminase and bilirubin test.
Shibata
H
H
Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.
Hisano
T
T
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005688:Galactosamine / Q000494:pharmacology*; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010833:Phytic Acid / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains
D015609:Organotechnetium Compounds; C026177:technetium phytate; D005688:Galactosamine; D010833:Phytic Acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin