Effect of antibiotics on laser-induced thrombus formation in rat mesenteric arterioles.
Antibiotics were tested in a thrombosis model, in which thrombi are produced in small rat mesenteric arterioles. An interference contrast system based on a Leitz Orthoplan microscope, was used to visualize thrombus formation. Vascular lesions were produced with a Coherent CR-2 supergraphite ion laser (argon laser) in arterioles of 25-35 microns diameter. Cefmenoxim, cefotaxim (i.v.) and cephalexin orally at doses of 20 and 40 mg/kg and gentamycin 10 and 20 mg/kg (i.v.) had a marked and significant antithrombotic effect. Even more effective were cefoperazon and lamoxactam 20 and 40 mg/kg (i.v.) and tobramycin 10 and 20 mg/kg (i.v.). Azlocillin, cefoxitin, mezlocillin or spectinomycin (20 mg/kg i.v.) and penicillin or piperacillin (50 mg/kg i.v.) also showed a significant antithrombotic effect, which, however, disappeared on doubling of the applied dose.
Weichert
W
W
Department of Internal Medicine, J.W. Goethe University, Frankfurt/Main, FRG.
Breddin
H K
HK
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001160:Arterioles / Q000187:drug effects; D001390:Azlocillin / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007231:Infant, Newborn; D007834:Lasers; D008638:Mesenteric Arteries / Q000187:drug effects*; D008802:Mezlocillin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology
D000900:Anti-Bacterial Agents; D010406:Penicillins; D001390:Azlocillin; D008802:Mezlocillin; D010878:Piperacillin