[The effect of emotional-pain stress syndrome on the biochemical characteristics of the stress-realizing system and metastasis of Lewis lung carcinoma in mice].
The emotional-pain stress (EPS) in C57BL mice with Lewis carcinoma was studied for its influence on serotoninergic, noradrenergic, dopaminergic, glutamatergic, aspartatergic, glycinergic, taurinergic, GABA-ergic and cholinergic mediator mechanisms of the hypothalamus, the level of corticotropin, free and bound 11-corticosteroids, insulin, thyroxin and testosterone in blood plasma as well as on the content of catecholamines, their precursors and catabolites in urine. EPS contributed to a long-term activation of stress-realizing systems resulting in generalization of decompensation in them. The stimulating effect of EPS on the incidence and growth of metastases is established depending on the terms of its application.
Valitskiĭ
K P
KP
Shmal'ko
Iu P
IuP
Pridatko
O E
OE
Smelkova
M I
MI
D000818:Animals; D007031:Hypothalamus / Q000503:physiopathology*; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D013315:Stress, Psychological / Q000150:complications* / Q000378:metabolism
Vliianie émotsional'no-bolevogo stressa na biokhimicheskie kharakteristiki stressrealizuiushchikh sistem i metastazirovanie kartsinomy legkikh L'iuis u mysheĭ.