title: Neuroleptic malignant syndrome: a case report with post-mortem brain and muscle pathology.
abstract: The neuroleptic malignant syndrome is a rare but dangerous complication of treatment with neuroleptics. The aetiology and pathophysiology of the syndrome are reviewed, and a fatal case is presented where both brain and muscle pathology are described. Striking myopathic changes in this case, accompanied by only minimal and non-specific brain abnormalities, support a peripheral rather than central mechanism for the hyperthermia.
authors: University of Bristol, UK.
authors: E M
authors: EM
authors: Jones
authors: A
authors: A
authors: Dawson
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D002545:Brain Ischemia / Q000473:pathology; D002746:Chlorpromazine / Q000008:administration & dosage / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007520:Isocarboxazid / Q000008:administration & dosage / Q000009:adverse effects*; D009132:Muscles / Q000473:pathology*; D009459:Neuroleptic Malignant Syndrome / Q000473:pathology*; D013345:Subarachnoid Hemorrhage / Q000473:pathology
chemical_list: D007520:Isocarboxazid; D002746:Chlorpromazine