A role for interleukin 1 in the in vivo actions of tumor necrosis factor.
We have observed a marked species specificity in the in vivo antitumor, shock-inducing and Interleukin-6 (IL-6)-inducing activities of human recombinant TNF (hrTNF) versus murine rTNF (mrTNF) in mouse models. We also have observed that this species specificity can be abolished when synergistic factors are co-administered. We now present data showing that the profiles of induced IL-6 and TNF after lethal and non-lethal doses of endotoxin are different. These results are discussed in the context of a model of dual signalling for the induction of the major post-endotoxin phenomena that takes into consideration the involvement of Interleukin-1 (IL-1) in the in vivo actions of TNF.
Brouckaert
P G
PG
Laboratory of Molecular Biology, State University of Gent, Belgium.
Libert
C
C
Everaerdt
B
B
Takahashi
N
N
Fiers
W
W
D000818:Animals; D004731:Endotoxins / Q000633:toxicity; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D015850:Interleukin-6; D007378:Interleukins / Q000096:biosynthesis; D007700:Kinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013045:Species Specificity; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000494:pharmacology*
D004731:Endotoxins; D007375:Interleukin-1; D015850:Interleukin-6; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha