[Differentiated changes in the activity of the sympathetic nerves induced by glycopenia in spontaneously hypertensive rats].
2-deoxy-D-glucose (2-DG) evokes an increase in the efferent discharge rate of the adrenal nerve in anesthetized rats and rabbits. A 63% increase in adrenal sympathetic nerve activity (adrSNA) occurred within 15 min after 125 mg/kg 2-DG administration in alert animals, no changes being revealed in the renal sympathetic nerve activity (renSNA), blood pressure (BP) or the heart rate (HR). Additional administration of 375 mg/kg 2-DG (cumulative dose 500 mg/kg) led to an over 120% increase in the adrSNA and the 20 mm Hg increase in the BP, whereas renSNA only increased by 30%. These results indicate that 2-DG-induced neuroglycopenia evokes highly differential changes in adrenal and renSNA in alert SHR rats. Whether this explains an obvious response of the BP in SHR to 2-DG, remains to be determined.
Medvedev
O S
OS
Delle
M
M
Thoren
P
P
D000311:Adrenal Glands / Q000187:drug effects / Q000294:innervation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D003847:Deoxyglucose / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004566:Electrodes; D005947:Glucose / Q000172:deficiency*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007668:Kidney / Q000187:drug effects / Q000294:innervation; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*
D003847:Deoxyglucose; D005947:Glucose
Differentsirovannye izmeneniia aktivnosti simpaticheskikh nervov, vyzvannye glikopenieĭ, u spontanno gipertenzivnykh krys.