Syntheses and comparison of three reagents for allyldimethylsilylation of prostaglandins and steroids: a gas chromatographic method.
Three reagents used for allyldimethylsilylation of prostaglandins and steroids have been prepared: N,O-bis(allyldimethylsilyl)trifluoroacetamide, N-methylallyl-dimethylsilyltrifluoroacetamide and allyldimethylsilyl-N,N-diphenylamine. The reaction kinetics of the reagents have been studied at room temperature in several solvents, and the optimal conditions for the derivatization of prostaglandins and steroids are discussed.
Steffenrud
S
S
Inflammation and Immunology-Rheumatology, Research Unit, Le Centre Hospitalier de l'Université Laval, Quebec, Canada.
Borgeat
P
P
Bertrand
M J
MJ
D000081:Acetamides; D000498:Allyl Compounds; D002849:Chromatography, Gas; D015237:Dinoprost / Q000032:analysis; D004159:Diphenylamine / Q000031:analogs & derivatives; D005463:Fluoroacetates; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D017646:Organosilicon Compounds; D011453:Prostaglandins / Q000032:analysis*; D012825:Silicon; D013256:Steroids / Q000032:analysis*; D014269:Trifluoroacetic Acid
D000081:Acetamides; D000498:Allyl Compounds; D005463:Fluoroacetates; D007202:Indicators and Reagents; D017646:Organosilicon Compounds; D011453:Prostaglandins; D013256:Steroids; C052198:N,O-bis(allyldimethylsilyl)-2,2,2-trifluoroacetamide; C061584:N-methylallyldimethylsilyltrifluoroacetic acid; C061583:allyldimethylsilyl-N,N-diphenylamine; D004159:Diphenylamine; D015237:Dinoprost; D014269:Trifluoroacetic Acid; D012825:Silicon