Respiratory activities of intralaryngeal branches of the recurrent laryngeal nerve.
To distinguish experimentally between motor nerve activity destined for vocal cord abductor muscles and that bound for muscles that adduct the cords, we recorded efferent activities of intralaryngeal branches of the recurrent laryngeal nerve (RLN) in decerebrate, vagotomized, paralyzed, ventilated cats. Activities of the whole RLN and phrenic nerve were also recorded. Nerve activities were assessed at several steady-state end-tidal O2 and CO2 concentrations. The nerve to the thyroarytenoid (TA) muscle, a vocal cord adductor, was only slightly active under base-line (normocapnic, hyperoxic) conditions but in most cats developed strong activity during expiration in hypocapnia or hypoxia. In severe hypocapnia, phasic expiratory TA activity persisted even during phrenic apnea, indicating continuing activity of the respiratory rhythm generator. The nerve to the posterior cricoarytenoid (PCA) muscle, the vocal cord abductor, was always active in inspiration but often showed expiratory activity as well. This expiratory activity was usually enhanced by hypercapnia and often inhibited by hypoxia. The results are consistent with previous electromyographic findings and emphasize the importance of distinguishing abductor from adductor activity in studies of laryngeal control.
Zhou
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D
Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire 03756.
Huang
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Q
St John
W M
WM
Bartlett
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D
D000818:Animals; D002415:Cats; D003655:Decerebrate State; D004525:Efferent Pathways / Q000502:physiology; D005260:Female; D006935:Hypercapnia / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D007823:Laryngeal Nerves / Q000502:physiology*; D008297:Male; D009046:Motor Neurons / Q000502:physiology; D010243:Paralysis / Q000503:physiopathology; D010791:Phrenic Nerve / Q000502:physiology; D012009:Recurrent Laryngeal Nerve / Q000502:physiology*; D012119:Respiration; D012132:Respiratory Muscles / Q000294:innervation / Q000502:physiology; D014630:Vagus Nerve / Q000502:physiology