Decreased protein kinase C activity in fatty liver from cattle.
Protein kinase (PK) C activity in the liver of cattle with fatty liver syndrome was evaluated and compared with that in liver of healthy cattle. The PKC activities in cytosolic and particulate fractions were reduced in fatty livers, compared with those in livers from healthy cattle. The decrease of PKC activity was more distinct in cytosolic (P = 0.0016) than particulate (P = 0.069) fractions. Protein kinase activities other than PKC were not substantially changed. Seemingly, PKC was involved in the pathogenesis of fatty liver syndrome in cattle.
Katoh
N
N
Hokkaido Branch Laboratory, National Institute of Animal Health, Sapporo, Japan.
Kimura
K
K
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000201:enzymology* / Q000378:metabolism; D002855:Chromatography, Thin Layer; D005234:Fatty Liver / Q000201:enzymology / Q000662:veterinary*; D005260:Female; D008099:Liver / Q000201:enzymology*; D008107:Liver Diseases / Q000201:enzymology / Q000662:veterinary*; D008297:Male; D011493:Protein Kinase C / Q000032:analysis / Q000378:metabolism*; D013577:Syndrome
D011493:Protein Kinase C