In vitro activity of minocycline and rifampin against staphylococci.
We tested the in vitro inhibitory and bactericidal activity of minocycline against 26 methicillin-susceptible Staphylococcus aureus, 24 methicillin-resistant S. aureus, 1 methicillin-susceptible coagulase-negative staphylococci, and 33 methicillin-resistant coagulase-negative staphylococci. Minocycline and rifampin had MIC90 results in the susceptible range, but MBCs were markedly elevated for minocycline alone (MBC50 greater than 32 micrograms/ml). The combination of minocycline and rifampin was synergistic for 30% of the isolates with the highest rates of synergy being against methicillin-resistant isolates.
Segreti
J
J
Rush-Presbyterian-St. Luke's Medical Center, Section of Infectious Disease, Chicago, Illinois.
Gvazdinskas
L C
LC
Trenholme
G M
GM
D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D013754:Tetracyclines / Q000494:pharmacology*
D013754:Tetracyclines; D008911:Minocycline; D012293:Rifampin