Genetic studies of typical Alzheimer's disease.
Typical, late-onset Alzheimer's disease is familial but shows no clear Mendelian pattern of inheritance. Strategies that could help to reveal its genetics are: 1) identification of genetically homogeneous phenotypes, 2) identification of early or alternate manifestations of AD gene expression in relatives, and 3) use of small multiplex families with cases of typical AD for linkage studies.
Mohs
R C
RC
Psychiatry Service, Veterans Administration Medical Center, Bronx, NY 10468.
Greenberg
D A
DA
Silverman
J M
JM
D000544:Alzheimer Disease / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21; D008040:Genetic Linkage; D006801:Humans; D010375:Pedigree