Anal sphincter dysfunction in Parkinson's disease.
Striated anal sphincter function was studied electrophysiologically and radiologically in six patients with Parkinson's disease and chronic constipation. In five cases, there was paradoxic anal sphincter muscle contraction during simulated defecation straining resembling anismus-type pelvic outlet obstruction. Radiologic studies showed functional improvement of the defecatory mechanism following the administration of the dopamine receptor agonist apomorphine in four patients. Dysfunction of the striated anal sphincter musculature may be a significant cause of constipation in some parkinsonian patients, occurring as part of the generalized extrapyramidal motor disorder.
Mathers
S E
SE
Department of Physiology, St Mark's Hospital, London, England.
Kempster
P A
PA
Law
P J
PJ
Frankel
J P
JP
Bartram
C I
CI
Lees
A J
AJ
Stern
G M
GM
Swash
M
M
D001003:Anal Canal / Q000503:physiopathology*; D003248:Constipation / Q000209:etiology*; D003672:Defecation / Q000502:physiology; D004576:Electromyography; D005260:Female; D005471:Fluoroscopy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*