[Cortisol level and immunosuppression in viral hepatitis B in children and the approach to its treatment with glucocorticoids].
As many as 132 children with verified virus hepatitis were examined. Cortisol content in blood serum was measured and the parameters of cellular-humoral immunity were determined over time in the acute period and in the catamnesis up to 1 year. In the cyclic self-limiting forms of hepatitis B, the children developed immunologic unbalance with progressive hypercortisolemia, being an adequate reaction of the stressor systems and not requiring prednisolone administration. In protracted and chronic persistent hepatitis, the children developed immunosuppression and monotonous hypercortisolemia requiring short-term prednisolone treatment. The children afflicted with the grave and malignant forms of hepatitis B demonstrated, within the early times of the disease, secondary immunodeficiency and a considerable drop of cortisol content, demanding early prednisolone administration.
Balikin
V F
VF
Panova
L A
LA
Sukharev
V M
VM
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006509:Hepatitis B / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007108:Immune Tolerance / Q000187:drug effects*; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D011239:Prednisolone / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000276:immunology
D007136:Immunoglobulins; D011239:Prednisolone; D006854:Hydrocortisone
Urove'n kortizola i dinamika immunodepressii pri virusnom gepatite B u deteĭ i podkhody k lecheniiu gliukokortikoidami.