title: Interleukin 2 promotes expression of an interleukin 2 receptor and proliferation of T cells stimulated with non-mitogenic dose of concanavalin A.
abstract: Interleukin 2 (IL-2) initiated proliferation of the cells of T-enriched population stimulated with non-mitogenic dose of concanavalin A (Con A), whereas it could not induce proliferation of the cells treated with non-mitogenic lectin wheat germ agglutinin (WGA). Use of monoclonal antibody (MAb) directed against interleukin 2 receptor (IL-2R) showed that IL-2 significantly increased expression of IL-2R on the cells of T-enriched population stimulated with Con A, whereas it could not cause any significant enhancement of expression of IL-2R on the cells treated with WGA. We concluded that IL-2 activated T cells in combination with non-mitogenic does of Con A, and induced both expression of IL-2R and proliferation.
authors: Department of Pathology, Mie University School of Medicine, Japan.
authors: H
authors: H
authors: Komada
authors: H
authors: H
authors: Nakabayashi
authors: M
authors: M
authors: Hara
authors: M
authors: M
authors: Hara
authors: T
authors: T
authors: Takahashi
authors: J
authors: J
authors: Morita
authors: T
authors: T
authors: Yoshida
authors: H
authors: H
authors: Takanari
authors: K
authors: K
authors: Izutsu
mesh_terms: D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000494:pharmacology*; D008213:Lymphocyte Activation; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000276:immunology*; D014909:Wheat Germ Agglutinins / Q000494:pharmacology
chemical_list: D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D014909:Wheat Germ Agglutinins; D003208:Concanavalin A