Functional brain asymmetry and murine systemic lupus erythematosus.
The role of brain lateralization in antibody production was studied in a murine systemic lupus erythematosus model. Male and female New Zealand black mice that spontaneously produce pathogenic auto-antibodies directed against red blood cells and DNA, were divided into right- and left-handers using a paw preference test, and anti-erythrocyte and anti-DNA antibody production was repeatedly determined. In females, antibodies against erythrocytes and double-stranded DNA appeared earlier in left-handers. These results provide the first evidence of an association between a functional brain asymmetry and auto-antibody production and suggest the involvement of the central nervous system in the pathogenesis of autoimmune processes.
Neveu
P J
PJ
INSERM U. 259, Laboratorie de Psychobiologie des Comportements Adaptatifs, Université de Bordeaux II, France.
Betancur
C
C
Barnéoud
P
P
Preud'Homme
J L
JL
Aucouturier
P
P
LeMoal
M
M
Vitiello
S
S
D000375:Aging / Q000276:immunology*; D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001921:Brain / Q000276:immunology* / Q000503:physiopathology; D004247:DNA / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000503:physiopathology*; D008297:Male; D051379:Mice
D001323:Autoantibodies; D004247:DNA