[Principles of growth of unidirectional combined effects of harmful substances after increase in their quantity].
The experiments on the impact of 4 noxious substances (copper, lead, zinc and cadmium salts) were carried out separately and in all possible combinations on 2 pure lines of cell culture. It was found out that a detrimental combined effect grew more slowly than one could expect proceeding from theoretical assumptions. The technique for calculating the maximum effect of the combination of noxious substances was proposed.
Annaeva
L R
LR
Khvastunov
R M
RM
D000818:Animals; D002104:Cadmium / Q000008:administration & dosage / Q000633:toxicity*; D002478:Cells, Cultured; D003300:Copper / Q000008:administration & dosage / Q000633:toxicity*; D006224:Cricetinae; D003412:Cricetulus; D004357:Drug Synergism; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007822:Laryngeal Neoplasms / Q000473:pathology; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D014116:Toxicology / Q000592:standards*; D015032:Zinc / Q000008:administration & dosage / Q000633:toxicity*
D002104:Cadmium; D007854:Lead; D003300:Copper; C028419:cuprous chloride; D015032:Zinc
O zakonomernosti narastaniia éffekta odnonapravlennogo sov- mestnogo deĭstviia vrednykh veshchestv pri uvelichenii ikh kolichestva.