title: Acute inflammatory response of the rat pawskin to acid injury is attenuated by corticotropin-releasing factor.
abstract: Increased vascular permeability, as measured by changes in skin weight and Evans blue dye extravasation, was produced in the skin after immersion of the anesthetized rat's paw in 12 N hydrochloric, 18N sulfuric, or 14N hydrofluoric acids for 2 min. Corticotropin-releasing factor (CRF), a 41-residue peptide having the rat/human sequence, injected 28 micrograms/kg i.v. 10 min before immersion, was efficacious in reducing these indices of skin injury.
authors: School of Public Health, University of California, Berkeley 94720.
authors: J Q
authors: JQ
authors: Tian
authors: E T
authors: ET
authors: Wei
mesh_terms: D000143:Acids; D000818:Animals; D002057:Burns, Chemical / Q000473:pathology; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000143:Acids; D003346:Corticotropin-Releasing Hormone