Antitumor activity of steroid-containing platinum (II) complexes of 1R,2R-cyclohexanediamine and 2-(aminomethyl)-cyclohexylamine isomers against leukemia L1210.
Various steroid-containing platinum (Pt) complexes of 1R,2R-cyclohexanediamine (= 1R,2R-dach) and cis-dl- and trans-dl-2-(aminomethyl)cyclohexylamine (= amcha) were synthesized and their antitumor activity was screened against leukemia L1210 according to the Pt Analog Study Protocol. Among the Pt complexes prepared, Pt 1R,2R-dach complexes of cortisone, hydrocortisone, methylprednisolone, testosterone, estriol and progesterone showed very high antitumor activity. Pt complexes of cis-dl- and trans-dl-amcha prednisolone, Pt(17-OH-progesterone) (trans-dl-amcha), Pt complexes of cis-dl- and trans-dl-amcha progesterone were found to be very effective.
Kidani
Y
Y
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Suzuki
K
K
Noji
M
M
Tashiro
T
T
D000818:Animals; D004353:Drug Evaluation, Preclinical; D007939:Leukemia L1210 / Q000188:drug therapy*; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D013256:Steroids / Q000494:pharmacology*
D009944:Organoplatinum Compounds; D013256:Steroids