Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1.
Interleukin-1 (IL-1) is a major regulator of inflammation and immunity. IL-1 induces T lymphocyte growth by acting as a second signal (together with antigen) in enhancing the production of interleukin-2 (IL-2). An IL-1-responsive element in the promoter region of the human IL-2 gene was similar to the binding site for the transcription factor AP-1. IL-1 enhanced expression of c-jun messenger RNA, whereas the antigenic signal enhanced messenger RNA expression of c-fos. Thus, the two components of the AP-1 factor are independently regulated and the AP-1 factor may serve as a nuclear mediator for the many actions of IL-1 on cells.
Muegge
K
K
Laboratory of Molecular Immunoregulation, Program Resources Inc., Frederick, MD 21701.
Williams
T M
TM
Kant
J
J
Karin
M
M
Chiu
R
R
Schmidt
A
A
Siebenlist
U
U
Young
H A
HA
Durum
S K
SK
D000818:Animals; D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D007376:Interleukin-2 / Q000235:genetics*; D051379:Mice; D011401:Promoter Regions, Genetic / Q000235:genetics; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014162:Transfection; D014407:Tumor Cells, Cultured
D007375:Interleukin-1; D007376:Interleukin-2; D016755:Proto-Oncogene Proteins c-jun; D015500:Chloramphenicol O-Acetyltransferase; D013755:Tetradecanoylphorbol Acetate