Effects of gossypol on Na+, K+ transmembrane fluxes in human red cells.
The effects of gossypol-acetic acid (a male contraceptive) on transmembrane fluxes of sodium and potassium in human red cells were studied, in comparison with the effects of ouabain (an inhibitor of Na+-K+-ATPase) and furosemide (an inhibitor of Na+, K+ cotransport). It was found that gossypol may be an inhibitor of outward (Na+, K+) cotransport in human red cells but has no significant effect on (Na+, K+)-ATPase. The results provide new evidence for elucidating the mechanism of hypokalemia caused by gossypol.
Jin
Y
Y
Chen
H C
HC
Wo
W H
WH
Yang
M Z
MZ
Xue
S P
SP
D004910:Erythrocyte Membrane / Q000378:metabolism*; D006072:Gossypol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D011188:Potassium / Q000493:pharmacokinetics*; D012964:Sodium / Q000493:pharmacokinetics*
D012964:Sodium; D006072:Gossypol; D011188:Potassium; C028178:gossypol acetic acid