[Clinico-electroencephalographic indices of the parkinsonian syndrome induced by MPP+ in rats].
The bilateral intranigral injection of 1-methyl-4-phenyl-pyridinium ion (MPP+) (10 g) produced significant oligokinesia, rigidity and weak tremor in rats. The extrapyramidal disturbances manifest a high-amplitude paroxysmal activity (PA) in the structures studied. It was found that the Pa was remarkable and more stable in the caudata nucleus than in other brain structures. It is PA that gives us the real basis to conclude the formation of the generator of pathologically enhanced excitation (GPEE) in the caudata nuclei. The analysis of PA dynamics revealed that the formation of the GPEE in the caudata nuclei correlated with development of parkinsonian syndrome (PS).
Kryzhanovski?
G N
GN
Atadzhanov
M A
MA
Voronina
T A
TA
Nerobkova
L N
LN
Zagorevski
V A
VA
D015655:1-Methyl-4-phenylpyridinium; D000818:Animals; D004567:Electrodes, Implanted; D004569:Electroencephalography; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009498:Neurotoxins / Q000633:toxicity*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000175:diagnosis* / Q000503:physiopathology; D011726:Pyridinium Compounds / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
D009498:Neurotoxins; D011726:Pyridinium Compounds; D015655:1-Methyl-4-phenylpyridinium
Kliniko-élektroéntsefalograficheskie pokazateli parkinsonicheskogo sindroma, vyzvannogo MFP+ u krys.