title: A new technique to demonstrate flow limitation in partial expiratory flow-volume curves in infants.
abstract: Partial expiratory flow-volume (PEFV) curves in infants are generated by applying a compressive pressure over the chest wall with an inflatable jacket. This study addresses two issues: pressure transmission to and across the chest wall and whether flow limitation can be identified. Eleven infants sedated with chloral hydrate were studied. Pressure transmission to the chest wall, measured with neonatal blood pressure cuffs placed on the infant's body surface, was 72 +/- 4% of jacket pressure during compression maneuvers. The pressure transmission to the air spaces, determined by measuring airway pressure during a compression maneuver against an occluded airway, was 56 +/- 6% of jacket pressure. A significant amount of the applied pressure is therefore lost across both the jacket and chest wall. Rapid pressure oscillations (RPO) were superimposed on static jacket pressures while expiratory flow was measured. Absence of associated oscillations of flow measured at the mouth was taken to indicate that flow was independent of driving pressure and therefore limited. Flow limitation was demonstrable with the RPO technique in all infants for jacket pressures greater than 50 cmH2O; however, it was evident at jacket pressures less than 30 cmH2O jacket pressure in four infants with obstructive airway disease. The RPO technique is a useful adjunct to the compression maneuver utilized to generate PEFV curves in infants because it facilitates the recognition of expiratory flow limitation.
authors: Department of Medicine, Children's Hospital, Boston, Massachusetts 02115.
authors: F
authors: F
authors: Ratjen
authors: R
authors: R
authors: Zinman
authors: M E
authors: ME
authors: Wohl
mesh_terms: D006801:Humans; D007223:Infant; D008173:Lung Diseases, Obstructive / Q000503:physiopathology; D011312:Pressure; D012123:Pulmonary Ventilation / Q000502:physiology*; D013909:Thorax