Sex-related differences in doxapram-induced alteration of drug action in the rat.
Pretreatment of rats with doxapram (20 mg/kg, i.p.) potentiates the duration of hexobarbital hypnosis and inhibits the rate of hepatic hexobarbital metabolism in female rats but not male rats. These data show that there is a sex-related difference in the ability of doxapram to alter both the drug response and hepatic drug metabolism in rats.
Ishikawa
M
M
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Ozaki
M
M
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D001711:Biotransformation; D004315:Doxapram / Q000494:pharmacology*; D005260:Female; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D012890:Sleep / Q000187:drug effects
D004315:Doxapram; D006591:Hexobarbital; D006899:Mixed Function Oxygenases; C021352:hexobarbital hydroxylase