Induced hyperglycemia protects rats against mercuric chloride nephrotoxicity.
Male Sprague-Dawley rats made diabetic (n = 20) by injection of streptozotocin 65 mg/kg and weight matched controls (n = 19) were divided into unilaterally nephrectomized and intact groups prior to challenge with HgCl2 (3 mg/kg). Diabetic rats (D2, n = 9) did not show a rise in serum creatinine concentration (0.56 +/- 0.10 vs 0.48 +/- 0.10 mg/dl) after HgCl2 challenge, while control rats (C2, n = 10) had a significant (p less than 0.001) rise in serum creatinine levels (0.40 +/- 0.14 vs 2.60 +/- 0.42 mg/dl). Uninephrectomized rats (D1, n = 11) did not alter the protection afforded by diabetes (creatinine 0.69 +/- 0.14 vs 0.67 +/- 0.13 mg/dl), but control uninephrectomized rats (C1, n = 9) had a substantial rise (p less than 0.001) in serum creatinine (0.51 +/- 0.13 vs 3.81 +/- 0.72 mg/dl). We conclude that induced hyperglycemia protects rats against mercuric chloride toxicity.
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D058186:Acute Kidney Injury / Q000139:chemically induced; D000818:Animals; D003404:Creatinine / Q000097:blood; D006943:Hyperglycemia / Q000503:physiopathology*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008627:Mercuric Chloride / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D008627:Mercuric Chloride; D003404:Creatinine