title: Influence of pharmacological doses of calcitonin on serum osteocalcin concentration in patients with Paget's disease of the bone.
abstract: The effect of continuous infusion of calcitonin on serum osteocalcin concentration was studied in 14 patients with Paget's disease. In all patients serum osteocalcin was initially increased. Within 24 h calcitonin gradually reduced serum osteocalcin, a marker of osteoblastic activity. This means that inhibition of the function of the osteoclasts by calcitonin results in an inhibition of the osteoblasts within 24 h in patients with Paget's disease.
authors: Department of Internal Medicine, Eudokia Hospital, Rotterdam, The Netherlands.
authors: H
authors: H
authors: Mulder
authors: C
authors: C
authors: Schop
authors: J C
authors: JC
authors: Koster
mesh_terms: D000368:Aged; D002116:Calcitonin / Q000008:administration & dosage* / Q000494:pharmacology; D002135:Calcium-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000097:blood* / Q000188:drug therapy; D015675:Osteocalcin
chemical_list: D002135:Calcium-Binding Proteins; D015675:Osteocalcin; D002116:Calcitonin