[Pulmonary encephalopathy and disturbance in amino acids metabolism].
18 kinds of serum free amino acids (SFAAs) were determined in 35 patients suffering from cor pulmonale (CP) with acute exacerbation of chronic obstructive pulmonary disease (COPD). We found that the branched-chain AAs/aromatic AAs ratio (BCAAs/AAAs) was smaller in patients with pulmonary encephalopathy (PE) than those with respiratory failure (RF) only. For the PE patients, this ratio was still smaller during unconscious period than during conscious period. Some SFAAs related to neurotransmitters were also altered during unconscious period. However, there was no significant difference between CP patients with simple RF and those without RF. When RF was controlled, the SFAAs remained unchanged. The above results suggested that disturbance in neutral AAs metabolism participates in the mechanism of PE formation.
Xu
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Zheng
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D000368:Aged; D000596:Amino Acids / Q000378:metabolism*; D000597:Amino Acids, Branched-Chain / Q000378:metabolism; D001927:Brain Diseases / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011660:Pulmonary Heart Disease / Q000150:complications / Q000378:metabolism*
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain