The primary structure of a feline class I gene: striking similarity to HLA-A.
The sequence of a feline class I pseudogene and its comparison with class I genes from other species is presented. The gene isolated is a pseudogene because of the presence of four stop codons and two frame shift mutations in the first- and second-domain encoding exons, as well as a mutation in a splice acceptor site in the third intron. By sequence comparison with the other class I sequences determined to date, the FLA pseudogene is most closely related to the HLA-A locus products (88% nucleotide identity.
van Hoof
M
M
Department of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam.
de Geus
J P
JP
Roos
M
M
Brown
C
C
Jacobs
H
H
Ploegh
H
H
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002415:Cats / Q000235:genetics* / Q000276:immunology; D005796:Genes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D008285:Major Histocompatibility Complex; D008969:Molecular Sequence Data; D015183:Restriction Mapping
D015395:Histocompatibility Antigens Class I