T lymphocytes in allergen-induced late-phase reactions and asthma.
We have studied a number of aspects of the interrelationship between T lymphocytes and allergic inflammation. Using monoclonal antibodies and immunocytochemistry we have observed significant infiltration by CD3+/CD4+ T lymphocytes together with evidence of T cell activation in the allergen-induced late-phase skin reaction in human atopic subjects. These changes were accompanied by eosinophil infiltration and activation. Activated T cells were also detected in the blood of patients with acute severe asthma. The role of T lymphocytes in granulocyte chemotaxis and activation was also explored, using recombinant human lymphokines, and we have identified and characterized two lymphokines which have specific effects upon neutrophils.
Frew
A J
AJ
Department of Allergy and Clinical Immunology, Cardiothoracic Institute, London, UK.
Corrigan
C J
CJ
Maestrelli
P
P
Tsai
J J
JJ
Kurihara
K
K
O'Hehir
R E
RE
Hartnell
A
A
Cromwell
O
O
Kay
A B
AB
D000208:Acute Disease; D000911:Antibodies, Monoclonal / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D001249:Asthma / Q000276:immunology*; D004804:Eosinophils / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000502:physiology; D009504:Neutrophils / Q000502:physiology; D012882:Skin Tests; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D013997:Time Factors
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D008222:Lymphokines