title: Effect of changes in lung volume on respiratory system compliance in newborn infants.
abstract: Total respiratory system compliance (Crs) at volumes above the tidal volume (VT) was studied by use of the expiratory volume clamping (EVC) technique in 10 healthy sleeping unsedated newborn infants. Flow was measured with a pneumotachograph attached to a face mask and integrated to yield volume. Volume changes were confirmed by respiratory inductance plethysmography. Crs measured by EVC was compared with Crs during tidal breathing determined by the passive flow-volume (PFV) technique. Volume increases of approximately 75% VT were achieved with three to eight inspiratory efforts during expiratory occlusions. Crs above VT was consistently greater than during tidal breathing (P less than 0.0005). This increase in Crs likely reflects recruitment of lung units that are closed or atelectatic in the VT range. Within the VT range, Crs measured by PFV was compared with that obtained by the multiple-occlusion method (MO). PFV yielded greater values of Crs than MO (P less than 0.01). This may be due to braking of expiratory airflow after the release of an occlusion or nonlinearity of Crs. Thus both volume recruitment and airflow retardation may affect the measurement of Crs in unsedated newborn infants.
authors: Department of Pediatrics, Children's Hospital, Brigham and Women's Hospital, Boston, Massachusetts 02115.
authors: F
authors: F
authors: Ratjen
authors: R
authors: R
authors: Zinman
authors: A R
authors: AR
authors: Stark
authors: L E
authors: LE
authors: Leszczynski
authors: M E
authors: ME
authors: Wohl
mesh_terms: D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D008170:Lung Compliance; D008176:Lung Volume Measurements; D012123:Pulmonary Ventilation; D013990:Tidal Volume