Inhibition of IgG-mediated immunosuppression by a monoclonal anti-Fc receptor antibody.
IgG-antibodies can efficiently suppress the antibody response against their specific antigen. The suppressive capacity is dependent on intact Fc regions. However, it is not clear which of the Fc-mediated effector functions are necessary for the induction of immunosuppression. The monoclonal antibody 24G2, which binds to murine Fc receptors on macrophages and B cells, was used in the present study to address the question of whether IgG-mediated suppression is in fact dependent on the binding of IgG antibodies to Fc receptors on splenocytes. In a murine in vitro immunization system, 24G2 is shown to reverse efficiently the suppression of the sheep erythrocyte-specific antibody response. The role of B cells or macrophages as effector cells is discussed.
Heyman
B
B
Department of Immunology, Uppsala University, Sweden.
D000818:Animals; D000910:Antibodies, Heterophile / Q000096:biosynthesis; D000911:Antibodies, Monoclonal / Q000502:physiology*; D001202:Ascitic Fluid / Q000276:immunology; D001667:Binding, Competitive; D006736:Horses; D007108:Immune Tolerance; D007074:Immunoglobulin G / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D051381:Rats; D011917:Rats, Inbred Lew; D011961:Receptors, Fc / Q000276:immunology*; D012397:Rosette Formation; D012756:Sheep
D000910:Antibodies, Heterophile; D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D011961:Receptors, Fc