title: [The reaction of the endocrine cells of the gastrointestinal tract in response to exposure to 3,6-dichloropicolinic acid].
abstract: Silver-impregnated argentaffin cells both Ec, D1, G, P, S and K enteroendocrine cell types of rat gastrointestinal mucosa were investigated under light and electron microscopy after single oral administration of 3,6-dichloropicolinic acid. As a result, in pyloric-duodenal region Ec cells after a period of 1 hour had intensively secreted hormones. Ultrastructurally their cytoplasm and secretory granules were covered by expressed vacuolization. These data hypothetically elucidate the role of the endocrine regulations in developing barrier function of the gastrointestinal epithelium.
authors: V V
authors: VV
authors: Iaglov
authors: Iu R
authors: IuR
authors: Ptashekas
mesh_terms: D000818:Animals; D002838:Chromaffin System; D004064:Digestive System / Q000187:drug effects* / Q000648:ultrastructure; D004759:Enterochromaffin Cells / Q000187:drug effects* / Q000648:ultrastructure; D005753:Gastric Mucosa / Q000187:drug effects / Q000648:ultrastructure; D006540:Herbicides / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D010848:Picolinic Acids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D006540:Herbicides; D010848:Picolinic Acids; C011767:clopyralid
vernacular_title: Reaktsiia éndokrinnykh kletok zheludochno-kishechnogo trakta v otvet na vozdeĭstvie 3,6-dikhlorpikolinovoĭ kisloty.