Localization of human monoamine oxidase-A gene to Xp11.23-11.4 by in situ hybridization: implications for Norrie disease.
A cDNA for the neurotransmitter-degrading enzyme monoamine oxidase-A (MAO-A) has been assigned by in situ hybridization to the human X chromosome and subregionally localized to Xp11.23-11.4. As restriction fragments detected by this probe are deleted in some patients with Norrie disease, this assignment provides confirmation of the localization of the disease.
Levy
E R
ER
Genetics Laboratory, Department of Biochemistry, Oxford, United Kingdom.
Powell
J F
JF
Buckle
V J
VJ
Hsu
Y P
YP
Breakefield
X O
XO
Craig
I W
IW
D002871:Chromosome Banding; D002874:Chromosome Mapping; D006801:Humans; D008995:Monoamine Oxidase / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D014960:X Chromosome / Q000648:ultrastructure*
D008995:Monoamine Oxidase