Not all chromosome imbalance resulting from the 11q;22q translocation is due to 3:1 segregation in first meiosis.
The constitutional translocation between chromosomes 11 and 22 [t(11;22)(q23.3;q11.2)] is one of the best known rearrangements in the human genome. Hitherto only one type of unbalanced karyotype, namely 47,XX or XY, +der(22) t(11;22)(q23.3;q11.2) was found among offspring of the translocation carriers. This result is the product of a 3:1 segregation at meiosis. We report an alternative unbalanced karyotype. The proband's karyotype is 47,XY,t(11;22)(q23.3;q11.2), +der(22)t(11;22)(q23.3;q11.2)pat. This finding cannot be due to nondisjunction in first meiosis of the translocation carrier.
Lockwood
D H
DH
Genetics Center, Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
Farrier
A
A
Hecht
F
F
Allanson
J
J
D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D007621:Karyotyping; D008540:Meiosis; D014178:Translocation, Genetic