[Interaction of mitotic oscillators as a source of variability of cell cycle duration].
Interaction between membrane mitotic oscillators at the expense of exchange with the molecules of lipids (slow variable) and antioxidants (fast variable) was considered. Parameters of all the oscillators are equal, excluding a small noise added to the equation for lipids. These parameters are chosen in such a way that the oscillators are not far from the transition to the stable stationary state. The numerical modeling has shown that the exchange with lipids brings about the appearance of an additional limit cycle whose period is significantly greater than that of an autonomous oscillator. The addition of noise averages the behaviour of oscillators, and distribution according to cycle duration becomes broad and bimodal. Thus the exchange of the slow variable increases the dispersion of distribution of cell generation times. This conclusion seems to be true for any oscillator with similar dynamic properties.
Volkov
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EI
D001683:Biological Clocks; D002453:Cell Cycle; D050356:Lipid Metabolism; D008938:Mitosis
Vzaimodeĭstvie mitoticheskikh ostsilliatorov kak istochnik variabelnosti dlitelnosti kletochnogo tsikla.