Hypertension in black South Africans--new perspectives on old material.
Autopsy material was examined from cases diagnosed as malignant nephrosclerosis in the years 1956-1961, a period when adequate antihypertensive therapy had not yet become available, a second group of malignant nephrosclerosis from the years 1970-1980, an era during which effective antihypertensive therapy was available, and a third group of essential benign nephrosclerosis, once more from the early pretreatment period (1956-1961). The observations suggest that malignant and benign hypertension may be two different diseases. Further studies will be pursued to assess whether hypertensive renal changes seen in this study are a spectrum of one disease extending from malignant nephrosclerosis de novo presenting with acute renal failure or chronic renal failure to benign hypertensive nephrosclerosis.
Isaacson
C
C
School of Pathology, Department of Anatomical Pathology, South African Institute for Medical Research, Johannesburg.
Milne
F J
FJ
van Niekerk
I
I
D044383:Black People; D006801:Humans; D006973:Hypertension / Q000473:pathology*; D006974:Hypertension, Malignant / Q000473:pathology*; D008875:Middle Aged; D009400:Nephrosclerosis / Q000209:etiology*; D013019:South Africa; D013997:Time Factors