title: Does chromogranin a respond to short-term mild physiologic challenge?
abstract: Plasma chromogranin A, norepinephrine, epinephrine, blood pressure, and heart rate were examined in 51 unmedicated volunteers at rest, in response to postural stimulation, and in response to a mild behavioral stressor. The short-term stressors led to the expected increases in catecholamines, blood pressure, and heart rate; however, chromogranin A was not influenced by these stimuli. Chromogranin A levels were not higher in the hypertensives, nor were they correlated with any of the other physiological variables. Although chromogranin A is coreleased with catecholamines from the sympathoadrenomedullary system, it does not respond to modest short-term postural or psychological stimuli that simultaneously evoke changes in other variables relevant to the sympathetic nervous system.
authors: Department of Psychiatry, University of California, San Diego.
authors: J E
authors: JE
authors: Dimsdale
authors: D
authors: D
authors: O'Connor
authors: M
authors: M
authors: Ziegler
authors: P
authors: P
authors: Mills
mesh_terms: D000328:Adult; D001794:Blood Pressure; D053379:Chromogranin A; D002864:Chromogranins / Q000097:blood*; D004837:Epinephrine / Q000097:blood; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000097:blood*; D009419:Nerve Tissue Proteins / Q000097:blood*; D009638:Norepinephrine / Q000097:blood; D011187:Posture; D012016:Reference Values; D013312:Stress, Physiological / Q000097:blood*
chemical_list: C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins; D009419:Nerve Tissue Proteins; D009638:Norepinephrine; D004837:Epinephrine