Biocompatibility of carbon-carbon materials: blood tolerability.
Carbon-carbon composites are well known in the field of aerospace technology. Such composites have been proposed to be used as biomaterials, particularly in contact with blood. To evaluate their haemocompatibility, samples were tested in vivo and in vitro, using radiotracers. In vivo study showed the accumulation of platelets on the exposed surface material with any surface morphology, whereas platelet concentration in blood remained constant. In vitro study allowed us to distinguish, among entrapped platelets, active adhering platelets from those mechanically retained and it appeared that the bulk structure of materials influenced the adhesion mechanism of platelets.
Baquey
C
C
Unité 306-INSERM, Université de Bordeaux II, France.
Bordenave
L
L
More
N
N
Caix
J
J
Basse-Cathalinat
B
B
D000818:Animals; D001672:Biocompatible Materials; D002244:Carbon; D004285:Dogs; D066298:In Vitro Techniques; D008422:Materials Testing; D010973:Platelet Adhesiveness; D019736:Prostheses and Implants
D001672:Biocompatible Materials; D002244:Carbon