[Effects of thymosin and B-activin on lateralization of sensomotor control in rats].
Characteristics of regulatory effects of B-activin and thymosin (fraction 5) on the activity of right and left hemispheres were studied in rats. The results obtained were estimated basing on the analysis of the following components of food-searching behavior: lateralization of a single conditioned-reflex response; preference of right or left paw; spontaneous rotations. Opposite effects of thymosin and B-activin were found at different stages of the food-searching behavior. Thymosin activated structures of the left hemisphere. A conclusion is made on the possibility of application of these drugs for targeted influencing the balance of intra-hemispheric activity in the brain functional pathology and during the compensatory process.
Dobrynin
V P
VP
Fedan
V A
VA
Orbachesvskaia
I Iu
IIu
Pogozheva
E N
EN
Neprintseva
E S
ES
D028341:Activins; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001853:Bone Marrow; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D003214:Conditioning, Classical; D007839:Functional Laterality; D008297:Male; D009842:Oligopeptides; D010455:Peptides / Q000494:pharmacology*; D011597:Psychomotor Performance; D051381:Rats; D013947:Thymosin / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D009842:Oligopeptides; D010455:Peptides; C044147:activin B; D028341:Activins; C048617:myelopeptides; D013947:Thymosin
Vliianie timozina i B-aktivina na lateralizatsiiu sensomotornogo kontrolia u krys.