[Studies on the chemical constituents of the root of Desmos cochinchinensis Lour].
Desmos cochinchinensis as a folk medicine is used for treatment of malaria in China. Pharmacological studies showed that the petroleum ether extract of the root of the plant exhibited anti-malarial activity. Three flavonoids were isolated from this extract, of which two were identified as lawinal and isounonal. Compound III is a new flavanol. On the basis of spectroscopic analyses (UV, IR, MS, 1HNMR, 13CNMR and X-RD) the structure was established as 4,7-dihydroxyl-5-methoxyl-6-methyl-8-formyl-flavan. I and II were found from this plant for the first time.
Liao
S X
SX
Han
G Y
GY
Zhang
Y R
YR
Zheng
Q T
QT
He
C H
CH
D000962:Antimalarials; D055598:Chemical Phenomena; D002621:Chemistry; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D005419:Flavonoids / Q000302:isolation & purification*
D000962:Antimalarials; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C061425:4,7-dihydroxy-5-methoxy-6-methyl-8-formylflavan; C061398:lawinal; C061424:isounonal