title: [Pharmacokinetics of antimicrobial agents in the elderly].
abstract: The elderly can be easily infected by certain organisms due to underlying diseases and complications. The pharmacokinetics of cefotiam, ceftriaxone, ceftizoxime, cefpodoxime proxetil, carumonam, clarithromycin, amikacin, ofloxacin and lomefloxacin in the elderly should be considered when choosing antibiotics for elderly patient with regard to infected site, causative organisms, pharmacokinetics and side effects. Pharmacokinetics in the elderly reflect potential renal dysfunction, so that t1/2 was elongated and AUC increased with age. Intravenous administration in the elderly, especially in the subjects with low body weight, the administered dose and intervals must be considered. With oral administration there was no constant tendency of the intestinal absorption.
authors: T
authors: T
authors: Yamamoto
authors: K
authors: K
authors: Suzuki
authors: K
authors: K
authors: Yamamoto
authors: S
authors: S
authors: Adachi
mesh_terms: D000284:Administration, Oral; D000285:Administration, Rectal; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D007275:Injections, Intravenous
chemical_list: D000900:Anti-Bacterial Agents