[Health status of children born to women with renal pathology].
The children born to mothers suffering from glomerulonephritis, pyelonephritis and hereditary nephritis were followed up for 4-5 and more years. This allowed a conclusion about a considerable rate of the birth of children with pathology of the urinary system organs (USO) and with diseases of other organs which were diagnosed for the first time at the age of 3-10 years as a result of goal-oriented investigations. The groups of the children born to women with renal diseases were marked by a high perinatal lethality studied by means of retrospective questionnaire. As for the structure of the USO diseases, the children manifested the predominance of the disease patterns associated with dysembryogenesis at the organ (anatomic abnormalities), tissue (dysplasia of the renal tissue) and at the cellular levels (metabolic nephropathies). In children born to women with hereditary nephritis, USO pathology was of the same kind and occurred only in the form of hereditary nephritis, which corresponds to the concepts of monogenously inherited pathology. The demonstration during pregnancy of a considerable rate of the environmental effects capable of exerting a damaging action on the embryonal development of children born to women with glomerulo- and pyelonephritis suggests a concomitant genesis of USO diseases in children born to mothers suffering from renal diseases. The authors discuss measures aimed at the prevention or reduction of the incidence of USO pathology in children as well as at the recognition of pathologies in children born to women with renal diseases at the predisease stage.
Ignatova
M S
MS
Degtiareva
E M
EM
Fokeeva
V V
VV
D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000235:genetics*; D006801:Humans; D007223:Infant; D007668:Kidney / Q000002:abnormalities; D009394:Nephritis, Hereditary / Q000235:genetics*; D011704:Pyelonephritis / Q000235:genetics*
Sostoianie zdorov'ia deteĭ, rozhdennykh zhenshchinami s patologieĭ pochek.