[Activity of the nucleolar organizers in cardiomyocytes of patients with arterial hypertension of varying genesis].
A comparative study of the myocyte nucleolar organizer activity (NOA) was performed on silver-stained myocardium from 6 patients who had died from the hypertension disease and 7 others patients with secondary renal hypertension non-complicated by severe coronary atherosclerosis and heart failure. In the first group, positive correlations between NOA of cardiac cells and the level of maximal diastolic pressure (r = 0.8, p less than 0.028), wall thickness of the left ventricle (r = 0.8, p less than 0.028) as well as myocardial weight (r = 1.0, p less than 0.001) were found. In the second group, on the contrary, there was a pronounced negative correlation between NOA of the myocytes and myocardial weight (r = -0.86, p less than 0.005) which may be explained partially by a primary metabolic myocardial deficiency in such patients.
Gudkova
A Ia
AIa
Amineva
Kh K
KhK
Mamaev
N N
NN
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000473:pathology*; D006977:Hypertension, Renal / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000166:cytology / Q000473:pathology*; D009697:Nucleolus Organizer Region / Q000473:pathology*; D009929:Organ Size; D014176:Protein Biosynthesis; D012337:RNA, Ribosomal, 18S / Q000096:biosynthesis; D012339:RNA, Ribosomal, 28S / Q000096:biosynthesis
D012337:RNA, Ribosomal, 18S; D012339:RNA, Ribosomal, 28S
Aktivnost' iadryshkovykh organizatorov v kardiomiotsitakh bol'nykh s arterial'noĭ gipertenzieĭ razlichnogo geneza.