title: Cytotoxic T-cell response to influenza A subunit vaccine in patients with type 1 diabetes mellitus.
abstract: The cytotoxic T-cell and humoral immune response to a commercially available influenza A-H1N1 subunit vaccine in 14 patients with type 1 diabetes mellitus was compared with the response in 13 healthy volunteers. Cytotoxic T-cell response to vaccination was poor in both patients and controls. At a calculated 50: 1 effector-target cell ratio, however, significantly more controls than patients showed an increase of over 5% cytotoxic T-cell mediated lysis after vaccination (P less than 0.05). In patients the cytotoxic T-cell response decreased with higher percentages of glycosylated haemoglobin (regression coefficient not equal to 0 with P less than 0.05). No significant difference was found between diabetic patients and control subjects with respect to antibody response after vaccination. Implications for vaccination strategy are discussed.
authors: R J
authors: RJ
authors: Diepersloot
authors: K P
authors: KP
authors: Bouter
authors: R
authors: R
authors: van Beek
authors: C J
authors: CJ
authors: Lucas
authors: N
authors: N
authors: Masurel
authors: D W
authors: DW
authors: Erkelens
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines