Investigation of the roles of the substances in serum lipids and their constitutive fatty acids in chronic urticaria.
The newly-generated lipid mediators include products of arachidonate metabolism, prostaglandins and leukotrienes. In this study, serum lipids and fatty acids, including arachidonic acid (C20:4) were examined in 12 normal subjects (6 males and 6 females) and 23 subjects with chronic urticaria (6 males and 17 females), including 17 who made an excellent or good recovery (4 males and 13 females). The results indicated a relationship between chronic urticaria and serum lipids and fatty acids. The omega 6 (n-6) and omega 3 (n-3) series of polyunsaturated fatty acids and lipid peroxidation were suggested that may be one of the mediators in chronic urticaria. Pantethine, glutathione and ascorbic acid were effective in controlling chronic urticaria.
Kobayashi
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D000328:Adult; D001205:Ascorbic Acid / Q000627:therapeutic use; D002908:Chronic Disease; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D005978:Glutathione / Q000627:therapeutic use; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010204:Pantetheine / Q000627:therapeutic use / Q000031:analogs & derivatives; D014581:Urticaria / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology
D005227:Fatty Acids; D008055:Lipids; D010204:Pantetheine; C005425:pantethine; D005978:Glutathione; D001205:Ascorbic Acid