title: Phenanthrylalkanoic acids, III: Syntheses and biological activities of 4-phenanthryl derivatives.
abstract: Reformatsky reactions between 2,3-dihydro-4(1H)-phenanthrenone (5) and ethyl alpha-bromoacetate or propanoate yield several unsaturated esters which, upon aromatization followed by saponification, lead to the 4-phenanthrylacetic (1) and 2-(4-phenanthryl)propanoic (2) acids. The analgesic and anti-inflammatory properties of 1 and 2 were measured and compared with those of Fenbufen.
authors: A
authors: A
authors: Eirín
authors: F
authors: F
authors: Fernández
authors: G
authors: G
authors: Gómez
authors: C
authors: C
authors: López
authors: A
authors: A
authors: Santos
authors: J M
authors: JM
authors: Calleja
authors: E
authors: E
authors: Cano
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D051379:Mice; D010616:Phenanthrenes / Q000138:chemical synthesis*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010616:Phenanthrenes