The effect of smoking on the frequencies of asymmetrical and symmetrical chromosome exchanges in human lymphocytes.
Cytogenetic analysis was performed on blood lymphocyte cultures from 12 moderate smokers (15-20 cigarettes/day) and 12 non-smokers. An increase in dicentrics was observed in the smokers using block-stained material but this was not significant. Analysis of banded material, enabling both symmetrical and asymmetrical aberrations to be scored, revealed a significant increase in total aberrations thus emphasizing the need to identify all chromosome rearrangements when examining the effects of low-level chronic exposures to clastogens.
Tawn
E J
EJ
Geoffrey Schofield Cytogenetics Laboratory, BNF plc, Sellafield, Cumbria, Great Britain.
Cartmell
C L
CL
D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002883:Chromosomes, Human, Pair 14; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D008875:Middle Aged; D010947:Plants, Toxic; D012907:Smoking / Q000009:adverse effects*; D014026:Nicotiana