title: Conformation of a T cell stimulating peptide in aqueous solution.
abstract: Using two-dimensional NMR spectroscopy and circular dichroism spectroscopy it is demonstrated that a T cell stimulating peptide corresponding to residues 132-153 of sperm whale myoglobin populates helical conformations in aqueous solution. This finding is in accordance with proposals that immunodominant sites in T cell stimulating peptides have a high conformational propensity. The observation of secondary structure in aqueous solutions of this and other immunogenic peptides has important implications for initiation of protein folding.
authors: Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA 92037.
authors: J P
authors: JP
authors: Waltho
authors: V A
authors: VA
authors: Feher
authors: R A
authors: RA
authors: Lerner
authors: P E
authors: PE
authors: Wright
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D009211:Myoglobin / Q000032:analysis; D010455:Peptides / Q000032:analysis*; D011487:Protein Conformation; D012996:Solutions; D013601:T-Lymphocytes / Q000276:immunology*; D014907:Whales
chemical_list: D009211:Myoglobin; D010455:Peptides; D012996:Solutions