[Risk of myocardial infarct in 40 to 60-year-old males in relation to potential risk factors of atherosclerosis. Intermediate evaluation of the Göttingen risk, incidence and prevalence study following a 5-year observation period].
The main part of the Göttingen risk, incidence and prevalence study (GRIPS) is a prospective cohort-study (GRIPS-project B). In 1982 about 6,000 male subjects aged 40-60 years underwent an extensive, baseline examination. The incidences of death and disease are being recorded in this collective by regular follow-up investigations. A five-year observation period has now been completed for more than 95% of the original study participants. During this period 107 subjects, who had no symptoms of atherosclerotic diseases in 1982, developed fatal or non fatal myocardial infarction (MI). In the present evaluation this incidence group is compared to those study participants, who remained free of atherosclerotic diseases until December 1986 (reference group: n = 5160). The results indicate that LDL-cholesterol is the predominant predictor of MI-risk among all variables investigated. Additional risk factors of significance were as follows (in the rank order of their importance): positive family history of MI, hyperglycemia, low HDL-cholesterol, increased levels of triglyceride-rich-lipoproteins, hypertension, cigarette-smoking. For the most important risk-factor, LDL-cholesterol, 190 mg/dl seem to be a useful threshold value for therapeutic intervention according to the present data from GRIPS-project B. However, if additional risk-factors or definitive coronary artery disease are present, LDL-cholesterol levels below 140 mg/dl should be the therapeutic aim.
Cremer
P
P
Muche
R
R
Kruse-Lösler
B
B
Seidel
D
D
Labrot
B
B
D000328:Adult; D001161:Arteriosclerosis / Q000401:mortality*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005500:Follow-Up Studies; D005860:Germany, West / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality*; D011446:Prospective Studies; D012307:Risk Factors
Myokardinfarktrisiko bei 40- bis 60jährigen Männern in Abhängigkeit von potentiellen Risikofaktoren der Atherosklerose. Zwischenauswertungen der Göttinger Risiko-, Inzidenz- und Prävalenzstudie (GRIPS) nach einem 5jährigen Beobachtungszeitraum.