title: [The effect of central and peripheral neuroglia on the regeneration of the optic nerve].
abstract: The post-traumatic response of adult ganglion cell axons to the presence of regeneration-permissive environments was examined in the optic nerve of the adult rat. As a first goal, we elucidated the reasons why the optic nerve was not able to regenerate. We were able to show that ganglion cell axons growing in vitro could not penetrate an impediment consisting of purified central nervous system myelin. The results demonstrated that the intrinsic ability of central neurons to regrow their axons is suppressed by non-permissive central myelin. After total intraorbital transection of the optic nerve and either simultaneous anastomosis of an autologous transplant from the peroneus communis nerve, or anastomosis delayed for up to 6 weeks several thousand ganglion cell axons reelongated into the transplant and reached lengths of about 30 mm within 5 to 6 weeks. Regeneration-stimulating substances could be accumulated within silicone tubes implanted at the site of the lesion in the N. peroneus communis. Their neurotrophic activity was tested in vitro in the explanted adult retina. The results indicate that the regeneration-permissive peripheral neuroglia responds to lesions with the production and supply of neuritogenic substances. Such substances are also active in the explanted adult retina where they support central axonal reelongation.
authors: S
authors: S
authors: Thanos
authors: J
authors: J
authors: Vanselow
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D009416:Nerve Regeneration; D009457:Neuroglia / Q000502:physiology*; D009900:Optic Nerve / Q000502:physiology* / Q000601:surgery; D010543:Peroneal Nerve / Q000637:transplantation; D051381:Rats; D011917:Rats, Inbred Lew
vernacular_title: Einfluss der zentralen und peripheren Neuroglia auf die Regeneration des Nervus opticus.