Effects of ceruletide on post-operative intestinal atony: a manometric study.
The effects of ceruletide on jejunal motor activity were studied in seven patients with postoperative intestinal atony. Jejunal pressures were recorded by three perfused catheters with orifices spaced 5 cm apart, the proximal one being positioned 10 cm beyond the ligament of Treitz. Ceruletide (0.05 microgram/Kg i.v.) significantly (p less than 0.0001) increased the number and amplitude of jejunal contractions. The action of ceruletide was most obvious the first 15-minutes after administration, then its effect diminished progressively and ceased after 65-75 minutes. The adverse reactions of ceruletide were minimal and self-limiting.
Stanciu
C
C
Frasin
M
M
Bălan
G
G
Stratan
I
I
Carniciu
S
S
D000328:Adult; D002108:Ceruletide / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007410:Intestinal Diseases / Q000188:drug therapy* / Q000503:physiopathology; D007583:Jejunum / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy* / Q000503:physiopathology
D002108:Ceruletide