Effect of perioperative transfusions on survival in osteosarcoma treated by multimodal therapy.
We report on a retrospective study of 155 patients amputated for nonmetastatic osteosarcoma of the long bones. Among the various prognostic variables considered, a significant correlation was found only between survival and transfusions. In this report, the authors consider some hypotheses reported by others for tumors of a different nature and site and conclude that perioperative transfusion may induce depression in the immune response, which is the cause of a shorter survival in the patients reviewed.
Chesi
R
R
Transfusional Unit, Istituto Ortopedico Rizzoli, Bologna, Italy.
Cazzola
A
A
Bacci
G
G
Borghi
B
B
Balladelli
A
A
Urso
G
G
D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001803:Blood Transfusion; D001859:Bone Neoplasms / Q000401:mortality / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000401:mortality / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies
D000469:Alkaline Phosphatase