Caprolactam and benzoin: tests for induction of chromosome aberrations and SCEs in mouse bone marrow.
CAP and ZOIN were tested in vivo for their ability to induce sister-chromatid exchanges (SCE) and chromosome aberrations in mouse bone marrow cells. Single intraperitoneal injections of ZOIN to a maximum of 3000 mg/kg body weight failed to increase the number of SCEs in metaphases recovered 24 h post-treatment, and doses of 1500 mg/kg did not induce measurable increases in chromosome-aberration levels among first-division metaphases at 18 h. Similarly, neither endpoint showed a significant increase following near-lethal doses of 700 mg/kg of CAP. Two lower doses of each chemical were also ineffective. Under the in vivo conditions of our test system, both chemicals were cytogenetically inactive.
McFee
A F
AF
Medical and Health Sciences Division, Oak Ridge Associated Universities, TN 37831.
Lowe
K W
KW
D000818:Animals; D001381:Azepines / Q000633:toxicity*; D001573:Benzoin / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects*; D002209:Caprolactam / Q000633:toxicity*; D002869:Chromosome Aberrations; D008297:Male; D051379:Mice; D009153:Mutagens; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D001381:Azepines; D009153:Mutagens; D002209:Caprolactam; D001573:Benzoin