Coronary vasodilatation induced by calcitonin gene-related peptide in the anaesthetised pig.
The ability of CGRP to increase blood flow in the coronary circulation of the anaesthetized pig was studied in a constant pressure perfusion model. Human alpha-CGRP, when infused close-arterially into the left anterior descending coronary artery perfused at constant pressure, produced a marked and prolonged dose-related increase in coronary flow, at doses above 10 pmol min-1. The gradient of the flow/pressure curves at each dose increased with an increase in pressure, indicating a drop in the resistance of the coronary bed. No significant change was observed in heart rate, left ventricle pressure, mean arterial pressure or cardiac output.
Tippins
J R
JR
Department of Biochemistry, Imperial College of Science and Technology, London.
Greenwald
S E
SE
Lever
M J
MJ
MacIntyre
I
I
Morris
H R
HR
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide; D003326:Coronary Circulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects / Q000502:physiology; D007261:Infusions, Intra-Arterial; D009479:Neuropeptides / Q000097:blood / Q000494:pharmacology*; D010477:Perfusion; D013552:Swine; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
D009479:Neuropeptides; D014665:Vasodilator Agents; D015740:Calcitonin Gene-Related Peptide