[Spontaneous interleukin 1 secretion by alveolar macrophages from the bronchoalveolar lavage of patients with active sarcoidosis].
Alveolar macrophages from 28 patients with pulmonary sarcoidosis, from 6 patients with idiopathic pulmonary fibrosis and from 8 control subjects were tested for their spontaneous interleukin-1 release. Whereas alveolar macrophages from the controls and from the patients with idiopathic pulmonary fibrosis did not show a significant release of interleukin 1, 14 of the sarcoidosis patients displayed a considerable spontaneous interleukin-1 secretion. Besides radiographic signs of an increased disease activity these patients revealed a significantly elevated number of lymphocytes and a significantly increased T4/T8-ratio in the bronchoalveolar lavage indicating an enhanced inflammatory activity of sarcoidosis. The spontaneous interleukin-1 release is possibly due to a raised number of immature alveolar macrophages in the lung of patients with sarcoidosis.
Barth
J
J
I. Medizinische Klinik, Universitätsklinik Kiel.
Kreipe
H
H
Radzun
H J
HJ
Schumacher
U
U
Petermann
W
W
D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D007958:Leukocyte Count; D008171:Lung Diseases / Q000276:immunology*; D008214:Lymphocytes; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000276:immunology; D012507:Sarcoidosis / Q000276:immunology*
D007375:Interleukin-1
Spontane Interleukin-1-Sekretion aus Alveolarmakrophagen der bronchoalveolären Lavage von Patienten mit aktiver Sarkoidose.