[The decrease in thyroid hormones in CAPD is not explained either by iodine saturation or by dialysate loss].
Total T4, total T3 and TSH were measured in blood, urine and dialysate of 13 patients on CAPD. Iodine was measured in blood and urine. Free T4 and T3 were measured in blood only. Serum measurements revealed one true hypothyroidism, normal total T4, T3 and TSH for 12 patients, low free T4 and T3 with normal TSH for 9 patients. Iodine was slightly elevated for 3 patients. Urinary T4 and T3 were low. Dialysate T4 and T3 were low (T4 = 13, 6 nmol/24 H). Low free thyroid hormones are not relevant to iodine excess, nor to dialysate losses. Low free thyroid hormones may be considered as an endocrine dysfunction of chronic illnesses.
Verger
M F
MF
Service de Médecine Interne et Néphrologie Centre Hospitalier R. Dubos, Pontoise.
Verger
C
C
Abramovici
Y
Y
Larpent
L
L
Giraud
C
C
Bernard
M
M
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007455:Iodine / Q000032:analysis* / Q000097:blood / Q000652:urine; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D013972:Thyrotropin / Q000097:blood* / Q000652:urine; D013974:Thyroxine / Q000097:blood* / Q000652:urine; D014284:Triiodothyronine / Q000097:blood* / Q000652:urine
D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine
La diminution des hormones thyroïdiennes en DPCA ne s'explique ni par la saturation iodée ni par la perte dans le dialysat.