Ankylosing spondylitis in the Mexican mestizo: patterns of disease according to age at onset.
We studied 87 Mexican mestizo patients (82 men and 5 women) with definite ankylosing spondylitis (AS) with particular reference to juvenile and adult onset types. HLA-B27 was present in 32 of 38. Forty-seven patients (54.0%) had onset before the age of 16 years and 40 (46.0%) thereafter. By the end of the 1st year of disease, main features included spinal involvement in 44 (50.6%), peripheral arthropathy in 57 (65.5%) and enthesopathy in 41 (47.1%). Frequency of these increased up to 100.0, 79.3 and 64.4%, respectively, through the course of the disease. Peripheral arthritis and/or enthesopathy occurred in 89.4 and 63.1% of juveniles and 37.5 and 27.5% of adults, respectively, while lumbar pain and/or stiffness occurred in 23.4% of the former and 82.5% of the latter during the first year of disease. Additional findings were high erythrocyte sedimentation rate, anemia and hypergammaglobulinemia. Uveitis was the commonest extraarticular manifestation occurring in 20.6%. Our data suggest that the clinical pattern of AS in our patients was influenced by both age at onset and sex distribution of the disease.
Burgos-Vargas
R
R
Rheumatology Unit, Hospital General de Mexico, S.S. Mexico City.
Naranjo
A
A
Castillo
J
J
Katona
G
G
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D005260:Female; D015235:HLA-B Antigens / Q000032:analysis; D015796:HLA-B27 Antigen; D006801:Humans; D007198:Indians, North American; D007596:Joints / Q000473:pathology; D008297:Male; D008800:Mexico; D012737:Sex Factors; D013167:Spondylitis, Ankylosing / Q000473:pathology*
D015235:HLA-B Antigens; D015796:HLA-B27 Antigen