The angiotensinogen gene is located on mouse chromosome 8.
We have recently identified a cis-acting genetic lesion affecting angiotensinogen gene expression in testis and salivary gland. Accordingly, the angiotensinogen gene was assigned to mouse chromosome 8 by screening a series of hybrid cell lines for retention of mouse angiotensinogen sequences by genomic Southern analysis. In AKXD recombinant inbred mice, the angiotensinogen gene is 2.4 +/- 1.8 centiMorgan from Rn7S-8,a 7S RNA gene located on chromosome 8 (Taylor, B.A., personal communication). However, the segregation of salivary and testicular angiotensinogen expression phenotypes into inbred mouse strains was not concordant with the known chromosome 8 proviruses Emv-2, Mtv-21, Xmv-12 or Xmv-26.
Clouston
W M
WM
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia.
Fournier
R E
RE
Richards
R I
RI
D000808:Angiotensinogen / Q000235:genetics*; D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D006224:Cricetinae; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D015870:Gene Expression; D005796:Genes; D006822:Hybrid Cells / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats
D000808:Angiotensinogen; D004247:DNA