Monoamine oxidase inhibitor toxicity.
Monoamine oxidase inhibitor (MAOI) drugs are used in the treatment of depressive and anxiety disorders in adults. MAOIs are also used in high doses for the treatment of lymphomas and of central nervous system (CNS) tumors in children. Toxic effects resulted when procarbazine, a drug of this class, was used in treating a child with a CNS tumor. Psychotic reaction in the child may have been triggered by any of several factors, but arguments are for an organic cause. The implication of the MAOI procarbazine must be seriously considered. The case highlights potential serious problems associated with MAOIs and the interaction of this agent with other drugs.
Pfefferbaum
B
B
Pack
R
R
van Eys
J
J
D001932:Brain Neoplasms / Q000188:drug therapy; D002648:Child; D005260:Female; D005910:Glioma / Q000188:drug therapy; D006801:Humans; D011344:Procarbazine / Q000633:toxicity*; D019966:Substance-Related Disorders / Q000209:etiology*
D011344:Procarbazine