title: Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill.
abstract: Since the isolation of an HIV-2-related virus from captive macaques (SIVMAC), the origin of human immunodeficiency viruses, a much debated subject, has been attributed to monkeys. The sequence of SIVAGM, which is derived from a naturally infected African green monkey, shows equal relatedness to HIV-1 and HIV-2, suggesting that the derivation of these viruses from SIVAGM is unlikely. Recent sequence analysis of SIV from a captive sooty mangabey (SIVMAC), however, shows its close relatedness to HIV-2 and SIVMAC, indicating a possible origin of HIV-2 and SIVMAC from SIVSM (refs 4, 7, 9). We report here the sequence of a novel simian lentivirus, SIVMND, isolated from a wild-caught mandrill in Africa. It is distinct from the three other main groups, HIV-1, HIV-2/SIVMAC/SIVSM and SIVAGM, and therefore represents a fourth main group of primate lentiviruses. Phylogenetic analysis indicates that these four main virus groups might have diverged from a common ancestor at about the same time, long before the spread of AIDS in humans.
authors: Department of Animal Pathology, University of Tokyo, Japan.
authors: H
authors: H
authors: Tsujimoto
authors: A
authors: A
authors: Hasegawa
authors: N
authors: N
authors: Maki
authors: M
authors: M
authors: Fukasawa
authors: T
authors: T
authors: Miura
authors: S
authors: S
authors: Speidel
authors: R W
authors: RW
authors: Cooper
authors: E N
authors: EN
authors: Moriyama
authors: T
authors: T
authors: Gojobori
authors: M
authors: M
authors: Hayami
mesh_terms: D000818:Animals; D005075:Biological Evolution; D005681:Gabon; D005814:Genes, Viral; D006678:HIV / Q000235:genetics; D008969:Molecular Sequence Data; D010215:Papio / Q000382:microbiology*; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000302:isolation & purification; D014764:Viral Proteins / Q000235:genetics
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins