[Damage to the creatine phosphokinase of rat brain synaptosomes during molecular oxygen activation].
It was shown that activation of molecular oxygen by Fe2+ ascorbate causes damage to creatine phosphokinase of rat brain synaptosomes. The creatine phosphokinase inactivation did not correlate with activation of lipid peroxidation in synaptosomes. The enzyme damage was the result of direct interaction with active oxygen species.
Spiricheva
N V
NV
Aksenova
M V
MV
Orlov
O N
ON
Burbaeva
G Sh
GSh
Erin
A N
AN
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D003402:Creatine Kinase / Q000378:metabolism*; D005296:Ferrous Compounds / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000201:enzymology*
D005296:Ferrous Compounds; C051140:iron(II)-ascorbic acid complex; D008315:Malondialdehyde; D003402:Creatine Kinase; D001205:Ascorbic Acid
Povrezhdenie kreatinfosfokinazy sinaptosom mozga krys pri aktivatsii molekuliarnogo kisloroda.