Subgingival administration of tetracycline on a collagen film.
The purpose of this study was to evaluate the duration of therapeutic effect after administration of the collagen film immobilized tetracycline (TC film). TC film or tetracycline non-immobilized placebo film was applied one time to the periodontal pocket (greater than or equal to 4 mm) of five periodontitis patients (20 teeth). The clinical and microbiological effects are summarized as follows: The group that received TC film continued to show significantly low values for bleeding upon probing the pocket depth for 3 and 4 weeks, respectively, after administration, but there was no significant difference in the plaque index or gingival index when compared with the group that received a placebo film. In the TC film group, the density of microorganisms and the proportion of motile rods and spirochetes were also significantly decreased 3 weeks after administration. These findings suggest that topically administered TC film remains both clinically and bacteriologically effective for 2 to 3 weeks.
Minabe
M
M
Department of Periodontology, Kanagawa Dental College, Yokosuka, Japan.
Takeuchi
K
K
Tamura
T
T
Hori
T
T
Umemoto
T
T
D000287:Administration, Topical; D000328:Adult; D001419:Bacteria / Q000302:isolation & purification; D003094:Collagen; D003692:Delayed-Action Preparations; D003773:Dental Plaque / Q000382:microbiology; D003774:Dental Plaque Index; D005260:Female; D005881:Gingiva; D006801:Humans; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000188:drug therapy*; D010518:Periodontitis / Q000188:drug therapy*; D010919:Placebos; D013752:Tetracycline / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D010919:Placebos; D003094:Collagen; D013752:Tetracycline