Antinuclear and related autoantibodies in sera of healthy subjects with IgA deficiency.
The sera of 49 healthy IgA-deficient (SIgAD) subjects were evaluated for the presence of autoantibodies directed against 10 different nuclear and cytoskeletal antigens, as well as for the presence of the common lupus anti-DNA idiotype (16/6 Id). Twenty-nine sera were from IgG subclass-deficient subjects (4 = IgG2, 25 = IgG3), and 25 from normal healthy subjects, used as controls. The incidence of antinuclear but not anti-cytoskeletal antibodies were found to be significantly greater in the SIgAD group, as compared to the IgG-deficient subjects and the normal controls. Overall, 39% of SIgAD sera demonstrated polyreactivity, namely reactivity against more than one nuclear antigen. The incidence of specific antibody detection ranged from 37% against cardiolipin to 12% against RNP in the IgA-deficient group, albeit not with statistical significance in all cases when compared to the control group. Isotype evaluation of the antinuclear and related antibodies in the SIgAD group showed a greater tendency towards IgG. This increased incidence of autoantibody production in SIgAD may preceed the development of an overt autoimmune disease in the future.
Goshen
E
E
Department of Medicine D, Soroko Medical Center, Faculty of Health Science, Ben-Gurion University, Beer Sheva, Israel.
Livne
A
A
Krupp
M
M
Hammarström
L
L
Dighiero
G
G
Slor
H
H
Shoenfeld
Y
Y
D000361:Agammaglobulinemia / Q000276:immunology*; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology; D003599:Cytoskeleton / Q000276:immunology; D006801:Humans; D017098:IgA Deficiency; D017099:IgG Deficiency; D007132:Immunoglobulin Isotypes / Q000032:analysis
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D001324:Autoantigens; D007132:Immunoglobulin Isotypes