title: Modification of amygdala kindling by intracerebroventricularly administered gangliosides in rats.
abstract: The present study evaluated the effects of intracerebroventricularly (icv) administered total brain gangliosides on amygdala (AM) kindling in rats. The results showed the following: (i) exogenously injected gangliosides (0.4 and 0.8 mg/4 microliter) significantly decreased the afterdischarge threshold (ADT) in a dose-dependent manner; (ii) both 0.8 and 0.25 mg gangliosides significantly facilitated AM-kindled seizure development and shortened total AD duration when AM stimulation was given at 2-h intervals, especially in the late stages of kindling (stages 3-5); (iii) the facilitated kindled epileptogenesis by gangliosides was maintained persistently for more than 2 weeks; (iv) 0.25 mg gangliosides did not affect previously kindled seizures; (v) 0.8 mg gangliosides had a proconvulsant action in both nonkindled and kindled rats; and (vi) epileptiform responses to gangliosides markedly increased during kindling and remained increased for at least 5 weeks after kindling. It is concluded that gangliosides in neuronal membranes in the CNS may play an important role in the permanent hyperexcitability of kindled epileptogenesis.
authors: Department of Neuropsychiatry, Okayama University Medical School, Japan.
authors: Y
authors: Y
authors: Nakamura
authors: K
authors: K
authors: Morimoto
authors: M
authors: M
authors: Okamoto
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D004594:Electrophysiology; D004827:Epilepsy / Q000209:etiology / Q000503:physiopathology; D005732:Gangliosides / Q000008:administration & dosage / Q000494:pharmacology*; D006624:Hippocampus / Q000473:pathology; D007276:Injections, Intraventricular; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*
chemical_list: D005732:Gangliosides