Impact of NSAIDS on murine antigen induced arthritis. I. Investigation of antiinflammatory and chondroprotective effects.
The well known nonsteroidal antiinflammatory drugs (NSAID) diclofenac, piroxicam and tiaprofenic acid as well as the corticosteroid prednisolone, were examined for their effect on injury to knee joint structures evoked by a developing murine antigen induced arthritis. To ensure the human therapeutic dose, each drug was given twice a day per os in 3 different dosage regimes. The severity of arthritis was monitored with 99mTc-uptake measurements. After 3 weeks, mice were sacrificed and knee joints were examined histologically. All drugs exhibited, in comparable extent, antiinflammatory effects in terms of swelling. Grading of joint damage was focused on cartilage harm and chondrocyte activity. Only prednisolone provided sufficient protection and seemed to stimulate repair activity. The NSAID had no clear beneficial or adverse influences on affected cartilage. Apparently, under these experimental circumstances, only prednisolone functions chondroprotectively.
de Vries
B J
BJ
Department of Rheumatology, Academic Hospital Sint Radboud, Nijmegen, The Netherlands.
van den Berg
W B
WB
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001168:Arthritis; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D002358:Cartilage, Articular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D004008:Diclofenac / Q000627:therapeutic use; D007719:Knee Joint / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010894:Piroxicam / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use*; D011422:Propionates / Q000627:therapeutic use; D011509:Proteoglycans / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; D011509:Proteoglycans; D010894:Piroxicam; D004008:Diclofenac; C021270:tiaprofenic acid; D012710:Serum Albumin, Bovine; D011239:Prednisolone