[Immunologic assessment in habitual abortion].
Since 1985, after excluding nonimmunological reasons for habitual abortion, we have been performing an MCL, a cross-match, and an HLA typing in these patients. Those with a low MLC response and a negative cross-match are considered to be immunological aborters. Only three out of 42 examined couples showed a low response and in 21 of 24 tested couples the cross-match was negative. Of 36 patients with a high response, 10 had successful pregnancies; seven of them shared more than two HLA antigens. An immunological treatment is indicated in patients with low response and a negative cross-match. High responders should have another pregnancy without stimulation. HLA typing is without any consequences.
Strowitzki
T
T
Frauenklinik im Klinikum Grosshadern, Universität München.
Wiedemann
R
R
Mempel
W
W
Hepp
H
H
D000026:Abortion, Habitual / Q000235:genetics / Q000276:immunology*; D000483:Alleles; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D008285:Major Histocompatibility Complex; D011247:Pregnancy; D012307:Risk Factors
D006680:HLA Antigens
Immunologische Abklärung bei habituellen Aborten.