title: [Effects of middle-weight molecules on the mechanism of hemostasis].
abstract: Middle-weight molecules exert a marked anticoagulant effect, inhibit fibrinolysis and promote disaggregation of spontaneously aggregated blood platelets, decrease the degree of ADP-induced aggregation of blood platelets, and raise vascular permeability thus influencing the hemostatic potential of the blood. The types of the activity established are mainly detectable in the dialysed fraction of middle-weight molecules. After purification by means of dialysis the middle-weight molecule fraction promotes the formation of an active prothrombin-transforming complex without Ca++ in the presence of the matrix (tissue thromboplastin). On storage of the conserved donor's blood and plasma there occurs an accumulation of middle-weight molecule substances. This process is of moderate character, being two times more pronounced in the blood than in the plasma.
authors: V A
authors: VA
authors: Siatkovskiĭ
authors: V A
authors: VA
authors: Zmachinskiĭ
authors: L P
authors: LP
authors: Vasilenko
authors: O I
authors: OI
authors: Kim
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000096:biosynthesis*; D003029:Coagulants; D006801:Humans; D066298:In Vitro Techniques; D010977:Platelet Factor 3 / Q000096:biosynthesis*; D011516:Prothrombin / Q000096:biosynthesis*; D011817:Rabbits; D006435:Renal Dialysis / Q000009:adverse effects; D013927:Thrombosis / Q000209:etiology* / Q000517:prevention & control; D014118:Toxins, Biological / Q000097:blood*; D014511:Uremia / Q000097:blood* / Q000628:therapy
chemical_list: D001779:Blood Coagulation Factors; D003029:Coagulants; D014118:Toxins, Biological; C026865:uremia middle molecule toxins; D010977:Platelet Factor 3; D011516:Prothrombin
vernacular_title: Vliianie molekul sredneĭ massy na mekhanizmy gemostaza.