Light and electronmicroscopic examination of calf lung tissue after left ventricular assisted circulation with the spindle pump.
The influence of the spindle pump, a nonpulsatile blood pump, used as LVAD on calf lung tissue was examined by means of the actual 16th protoype which was applied in 3 "acute" tests up to 13 hours of pumping duration and 8 prolonged experiments with pumping periods up to 63 hours. Samples were taken during the operation and after exitus of the test animal and investigated by light and electronmicroscopy. Histological findings of tissue changes could be ascribed to mechanical manipulations and shock-like influences. Regardless of the time of nonpulsatile perfusion this tissue damage remained within an acceptable range, indicating the absence of a deleterious effect of nonpulsatile flow.
Hager
J
J
Surgical Clinic I, University of Innsbruck, Austria.
Dietze
O
O
Brandstaetter
F
F
Koller
I
I
Unger
F
F
D000818:Animals; D002417:Cattle; D004867:Equipment Design; D005260:Female; D006353:Heart-Assist Devices; D006439:Hemodynamics; D008168:Lung / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D013997:Time Factors