title: The vacuolated glycogen-laden leukemic lymphocytes of a T-cell lymphoproliferative disorder.
abstract: In this report, we present a case of peripheral T-cell leukemia/lymphoma having mostly small- to medium-sized cells with abundant clear cytoplasmic vacuoles. The presentation at the time of diagnosis was one of leukemia/lymphoma. The phenotype of the leukemic cells of the peripheral blood was T1+, T11+, TQ1+, interleukin-2+, T3-, T4-, and T8-. The cells in the peripheral blood as well as those obtained from lymph node biopsy were strongly periodic acid-Schiff positive; the positivity was diastase sensitive. Electron microscopy confirmed the presence of glycogen in the cytoplasmic vacuoles. Serologic tests were negative for human T-cell lymphotropic virus type 1 antibody. The data presented in this article support the existence of a vacuolated variant of peripheral T-cell leukemia/lymphoma and further expand the morphological spectrum of T-cell lymphoproliferative disorders.
authors: Department of Pathology, Medical College of Georgia, Augusta 30912-3620.
authors: J S
authors: JS
authors: Krauss
authors: C G
authors: CG
authors: Pantazis
authors: B O
authors: BO
authors: Spurlock
authors: L M
authors: LM
authors: Price
authors: A E
authors: AE
authors: Neeley
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005434:Flow Cytometry; D006003:Glycogen / Q000378:metabolism*; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D015458:Leukemia, T-Cell / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D010503:Periodic Acid-Schiff Reaction; D013601:T-Lymphocytes / Q000145:classification / Q000378:metabolism / Q000648:ultrastructure*; D014617:Vacuoles / Q000648:ultrastructure*
chemical_list: D006003:Glycogen