[Visually evoked responses as follow-up parameters in multiple sclerosis].
VEP- and MRI-changes were compared in 93 patients with definite or probable multiple sclerosis. A high correlation between slowing of visual conduction time and volume of peri-ventricular white matter lesions was found. The finding suggests a retrogenicular site of the pathogenic process being frequently responsible for VEP-abnormalities. Long-standing clinical courses show better VEP/MRI-correlations even without clinical symptoms, whereas acute cases more often have related visual disabilities but no convincing correlations. VEP represent one function of those regions in the brain which are frequently impaired by the demyelinating process in multiple sclerosis. They provide an optimal parameter of clinical course.
Hänny
P
P
Müller
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology; D005074:Evoked Potentials, Visual; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology / Q000503:physiopathology*
VEP als Verlaufsparameter bei multipler Sklerose.