title: [Effect of 7-aza- and 13-aza-prostanoids on platelet aggregation].
abstract: The effects of 11 new analogues of 7-aza- and 13-azaprostanoic acid on platelet aggregation of the rat were studied in vitro and ex vivo. The analogues of 13-azaprostanoic acid in vitro (10(-7)-10(-8) mol/l) were found to exhibit the antiaggregation activity in the blood. The compounds containing five-member cycle are more active antiaggregants. They decrease by 70-80% the degree of platelet aggregation stimulated by thrombin and ADP. The modification of omega-chain of these analogues (alkyl, phenyl) exerts no effect on the antiaggregation activity. The antiaggregation action of these compounds in ex vivo condition (5-10 micrograms/kg) does not preserve. 7-azaprostanoids possess the proaggregation activity in vitro.
authors: B B
authors: BB
authors: Kuz'mitskiĭ
authors: L P
authors: LP
authors: Malaeva
authors: T S
authors: TS
authors: Khlevnikova
authors: F A
authors: FA
authors: Lakhvich
mesh_terms: D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors; D000818:Animals; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000494:pharmacology; D005227:Fatty Acids / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011466:Prostanoic Acids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors
chemical_list: D003517:Cyclopentanes; D005227:Fatty Acids; D010975:Platelet Aggregation Inhibitors; D011466:Prostanoic Acids; C061721:7-azaprostanoic acid; D000244:Adenosine Diphosphate; C022574:13-azaprostanoic acid; D013917:Thrombin
vernacular_title: Vliianie nekotorykh 7-aza- i 13-azaprostanoidov na agregatsiiu trombotsitov.