title: HIV encephalopathy and lymphadenopathy: cells associated with viral antigens.
abstract: HIV associated subacute, micronodular encephalitis and lymphadenopathy were compared with regard to demonstrable HIV antigens and characterization of HIV antigen expressing cells. In the brain, both gag- and env-coded antigens were confined to cells of micronodular lesions with immunophenotype of monocyte/macrophages (KiM6+, 9.4+, CD4+/-). The micronodular lesions were also infiltrated by some lymphoid cells, predominantly CD8+. In lymphadenopathic nodes, gag-encoded antigens were demonstrable almost exclusively in follicles/germinal centres in association with follicular dendritic cells, whereas env-antigens usually were not found. Follicular involution was related to destruction of follicular dendritic cells and infiltration of CD8+ lymphocytes within the germinal centres. During follicular involution, HIV-gag antigens diminished in parallel with destruction of the network of dendritic reticulum cells. These findings indicate important tissue related differences in HIV expression. In addition, a possible participation of CD8+ cells in the pathogenesis of HIV induced tissue lesions is suggested.
authors: V Cattedra di Anatomia Patologica, Università di Milano, Italy.
authors: C L
authors: CL
authors: Parravicini
authors: A L
authors: AL
authors: Petrén
authors: L
authors: L
authors: Vago
authors: G
authors: G
authors: Costanzi
authors: J C
authors: JC
authors: Gluckman
authors: R C
authors: RC
authors: Gallo
authors: P
authors: P
authors: Biberfeld
mesh_terms: D000386:AIDS-Related Complex / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D000911:Antibodies, Monoclonal / Q000276:immunology; D001921:Brain / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D003713:Dendritic Cells / Q000276:immunology / Q000382:microbiology; D004660:Encephalitis / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D006678:HIV / Q000302:isolation & purification; D015488:HIV Antigens / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D009000:Monocytes / Q000276:immunology / Q000382:microbiology; D013601:T-Lymphocytes / Q000276:immunology / Q000382:microbiology
chemical_list: D000911:Antibodies, Monoclonal; D015488:HIV Antigens