Interleukin-1 production by polymorphonuclear leukocytes during the course of acute inflammation in rabbits.
Inflammation-induced immune enhancement was observed when an antigen was introduced during an early period of casein-induced inflammation. An immune potentiation factor was detected at the early inflammatory site of mice and rabbits. This immune potentiation factor of rabbits was identified as interleukin-1 (IL-1) in respect of either its biologic activities or its molecular structure. Expression of IL-1 mRNA was observed only in peritoneal exudate cells from the early inflammatory site in parallel with the generation of the immune potentiation activity. The inflammation-induced immune potentiation was assumed to be mediated by newly synthesized IL-1 at the early inflammatory site. By using immunocytochemical staining, it was definitely proved with respect to a single cell level that the polymorphonuclear leukocytes were the major cells in synthesizing IL-1 at the casein-induced inflammation in rabbits.
Ohkawara
S
S
Department of Pathology, Kumamoto University Medical School, Japan.
Goto
K
K
Mori
S
S
Goto
F
F
Saita
N
N
Sagara
T
T
Yoshinaga
M
M
D000208:Acute Disease; D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects; D002364:Caseins; D002454:Cell Differentiation; D002478:Cells, Cultured; D004195:Disease Models, Animal; D007249:Inflammation / Q000276:immunology / Q000378:metabolism*; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000378:metabolism; D051379:Mice; D009504:Neutrophils / Q000378:metabolism* / Q000502:physiology; D010538:Peritonitis / Q000139:chemically induced / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors
D002364:Caseins; D007375:Interleukin-1