title: [Molecular mechanisms of the action of local anesthetics].
abstract: Raman spectroscopy revealed a suppression of the polyene chain of C40-carotenoids in membrane of the frog nerve during local action of an anesthetic agent in resting and excitation. The phosphatidylcholine binding decreased during rhythmic excitation and local anesthetic action. A mechanism of potential-dependent changes of the carotenoid conformation during local anesthetic action, was discussed.
authors: G V
authors: GV
authors: Maksimov
authors: V Z
authors: VZ
authors: Pashchenko
authors: A B
authors: AB
authors: Rubin
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D003386:Brachyura; D002338:Carotenoids / Q000032:analysis; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008051:Lipid Bilayers / Q000032:analysis; D008563:Membrane Lipids / Q000032:analysis; D010713:Phosphatidylcholines / Q000378:metabolism; D011896:Rana temporaria; D011955:Receptors, Drug / Q000187:drug effects / Q000502:physiology; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology; D013059:Spectrum Analysis, Raman; D013329:Structure-Activity Relationship; D014316:Tritium
chemical_list: D000779:Anesthetics, Local; D008051:Lipid Bilayers; D008563:Membrane Lipids; D010713:Phosphatidylcholines; D011955:Receptors, Drug; D014316:Tritium; D002338:Carotenoids
vernacular_title: K voprosu o molekuliarnykh mekhanizmakh deĭstviia mestnykh anestektikov.