title: Air pollution by gasoline exhaust fumes: effect on platelet function and blood viscosity.
abstract: Air pollution induced by automobile exhaust fumes seems to be involved in increased cardiovascular and respiratory morbidity. The effects of inhalation of such pollutant gases on platelet function and blood viscosity have not been sufficiently investigated, even if these parameters seem to be in strict correlation with cardiovascular function. Twelve healthy non-smoking volunteers were exposed for 30 minutes in a closed room to air polluted by automobile fumes. Platelet aggregation, blood viscosity, HbCO levels and P50 STD were determined before and after exposure. Cardiovascular parameters (blood pressure, heart rate and ECG) were also measured. At the end of the test, HbCO levels were significantly increased, but P50 STD was significantly reduced; an impairment of both platelet function and blood viscosity was observed. No significant changes in cardiovascular parameters were recorded. The decreases in platelet aggregation and blood viscosity were not directly correlated with either the increase in carbon monoxide levels or with the reduced P50 STD levels. It can be reasonably concluded that gasoline exhaust fumes could have been responsible for the observed alterations.
authors: L
authors: L
authors: Coppola
authors: R
authors: R
authors: Giunta
authors: A
authors: A
authors: Grassia
authors: L
authors: L
authors: Misso
authors: G
authors: G
authors: Verrazzo
authors: P F
authors: PF
authors: Violano
authors: F
authors: F
authors: Grandillo
authors: A
authors: A
authors: Tirelli
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects*; D001784:Blood Gas Analysis; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D001809:Blood Viscosity / Q000187:drug effects*; D005742:Gasoline / Q000009:adverse effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010578:Petroleum
chemical_list: D000393:Air Pollutants; D005742:Gasoline; D010578:Petroleum