title: Peripheral nerve regeneration induces elevated expression of GAP-43 in the brainstem trigeminal complex of adult hamsters.
abstract: A polyclonal antibody was used to delineate the pattern of GAP-43 expression in central processes of trigeminal ganglion cells while their peripheral processes were undergoing regeneration. Two weeks after transection of the infraorbital nerve, levels of GAP-43 ipsilateral to the transection were greatly increased along the trajectory of infraorbital axons in the central trigeminal tract and also within the target neuropil. We conclude that elevated levels of GAP-43 in central processes of injured trigeminal ganglion cells occur in direct response to the regenerative response of the cell body and may have important implications for 'plasticity'-related changes seen in the adult trigeminal system.
authors: Department of Brain and Cognitive Sciences, Whitaker College, Massachusetts Institute of Technology, Cambridge 02139.
authors: R S
authors: RS
authors: Erzurumlu
authors: S
authors: S
authors: Jhaveri
authors: K L
authors: KL
authors: Moya
authors: L I
authors: LI
authors: Benowitz
mesh_terms: D000818:Animals; D006224:Cricetinae / Q000502:physiology*; D005260:Female; D019922:GAP-43 Protein; D005786:Gene Expression Regulation; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008647:Mesocricetus / Q000378:metabolism / Q000502:physiology*; D009416:Nerve Regeneration; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010525:Peripheral Nerves / Q000378:metabolism / Q000502:physiology*; D014276:Trigeminal Nerve / Q000378:metabolism / Q000502:physiology*
chemical_list: D019922:GAP-43 Protein; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins