Taenia crassiceps: experimental model of intraocular cysticercosis.
An experimental model of Taenia crassiceps intraocular cysticercosis was developed in rabbits. The objectives of this study were to analyze the pathophysiology of this parasitic infection and to evaluate the humoral immune response. Cysticerci, inoculated in the anterior chamber of the eye, were able to grow; no inflammatory changes in the eye or anticysticercus antibodies in serum or in aqueous humor were detected during the 12-day period. In contrast, rabbits that had previously been either infected intraperitoneally with living T. crassiceps cysts or immunized intramuscularly with T. crassiceps antigenic extract developed an intense inflammatory reaction in the eye and high levels of antibodies were detected in serum and aqueous humor even before the intraocular inoculation of parasites. Furthermore, intraocular cysticerci showed minimal growth and some were eliminated. These findings support the concept that the eye is an immunologically privileged site in the nonimmunized host and the importance of the immune response in the elimination of this parasitic infection.
Cárdenas
F
F
Departamento de Immunología, Universidad Nacional Autonoma de México, Mexico D.F.
Plancarte
A
A
Quiroz
H
H
Rabiela
M T
MT
Gómez-Leal
A
A
Correa
D
D
Flisser
A
A
D000818:Animals; D000867:Anterior Chamber / Q000469:parasitology; D000909:Antibodies, Helminth / Q000032:analysis; D003551:Cysticercosis / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D003552:Cysticercus / Q000254:growth & development / Q000276:immunology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D015822:Eye Infections, Parasitic / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D011817:Rabbits
D000909:Antibodies, Helminth