[Severe acute pneumopathy following low-dose methotrexate therapy in chronic polyarthritis].
A 70-year-old patient with a history of rheumatoid arthritis was hospitalized for severe acute pneumonitis after 36 weeks of treatment with low-dose methotrexate (7.5 mg/week). High dose corticotherapy and assisted ventilation were necessary to obtain a clinical response. Medical history, clinical signs, laboratory findings. X-ray films of the chest and special investigations suggest the diagnosis of acute low-dose methotrexate pneumonitis.
Quadri
F
F
Dipartimento di Medicina interna, Ospedale San Giovanni, Bellinzona.
Marone
C
C
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D008775:Methylprednisolone / Q000627:therapeutic use; D011014:Pneumonia / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D011859:Radiography; D012121:Respiration, Artificial
D008775:Methylprednisolone; D008727:Methotrexate
Schwere akute Pneumopathie nach "low-dose"-Methotrexat-Therapie bei chronischer Polyarthritis.