Functional heterogeneity of virgin and memory B murine lymphocytes revealed by the utilization of cyclosporin A: an overview.
The effects of cyclosporin A on the generation and revelation of B memory cells by thymus-independent (TI) antigens was investigated. A class 1 (TNP-LPS) and a class 2 (TNP-Ficoll) TI antigens were used for priming an elicitation. Evidence is presented that cyclosporin A does not interfere with the generation of hapten-specific (TNP) B memory cells by TNP-LPS or DNP-Ficoll. Cyclosporin A does not affect the revelation of B memory cells by TNP-LPS, but inhibits their revelation by TNP-Ficoll. These findings are discussed in terms of two distinct B cell lineages leading to antibody-forming cells and memory cells precursors, and in terms of heterogeneity of B memory cells.
Le Moal
M A
MA
Unité d'immunophysiologie moléculaire, Institut Pasteur, Paris, France.
Truffa-Bachi
P
P
D000818:Animals; D000955:Antigens, T-Independent / Q000276:immunology; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D003524:Cyclosporins; D005362:Ficoll / Q000276:immunology / Q000031:analogs & derivatives; D007156:Immunologic Memory / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D014301:Trinitrobenzenes / Q000276:immunology
D000955:Antigens, T-Independent; D003524:Cyclosporins; D008070:Lipopolysaccharides; C020529:TNP-ficoll; D014301:Trinitrobenzenes; C048761:trinitrophenyl-lipopolysaccharide; D005362:Ficoll