Hexahydrodifenidol does not distinguish among M1 receptors in rat cerebral cortex, hippocampus and superior cervical ganglion.
We have determined the antagonist affinity of hexahydrodifenidol in a range of receptor assays in the rat:-radioreceptor binding and phosphatidyl-inositol turnover assays in cerebral cortex and hippocampus, and electrophysiological experiments on the superior cervical ganglion and hippocampus. We failed to detect any appreciable differences in the affinity of hexahydrodifenidol among any of these assays.
Freedman
S B
SB
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, U.K.
Field
J L
JL
Gilbert
M J
MJ
Newberry
N R
NR
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D004594:Electrophysiology; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D010890:Pirenzepine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000187:drug effects*
D010880:Piperidines; D011976:Receptors, Muscarinic; C060685:hexahydrodifenidol; D010890:Pirenzepine