title: Mosaic reconstruction of blood vessels in mouse neocortical tissue transplanted into the third ventricle of rat brain.
abstract: Newborn mouse neocortical tissue was transplanted into the third ventricle of rat brain and the reconstruction and the origin of the blood vessels were investigated by using a monoclonal antibody against mouse endothelial surface antigen-1 (MESA-1). It was clearly demonstrated that some of the blood vessels in the graft originated in the donor mouse neocortical tissue. An India ink perfusion experiment revealed that the blood was supplied to the MESA-1-positive blood vessels. Furthermore, electron microscopic immunohistochemical studies demonstrated the existence of a mosaic reconstruction of blood vessels which consisted of mouse- and rat-derived vascular endothelial cells. It was concluded that the blood vessels originating in the donor tissue and those originating in the host tissue inoculate with each other in the grafted tissue.
authors: Department of Physiology, School of Medicine, Keio University, Tokyo, Japan.
authors: Y
authors: Y
authors: Nakano
authors: K
authors: K
authors: Takei
authors: S
authors: S
authors: Toya
authors: Y
authors: Y
authors: Tsukada
authors: S
authors: S
authors: Ghandour
authors: S
authors: S
authors: Kohsaka
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000098:blood supply / Q000637:transplantation*; D002552:Cerebral Ventricles / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D004730:Endothelium, Vascular / Q000166:cytology / Q000276:immunology*; D005260:Female; D006085:Graft Survival; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D011919:Rats, Inbred Strains; D014183:Transplantation, Heterologous
chemical_list: D000949:Histocompatibility Antigens Class II