Jaundiced Gunn rats have increased synaptic delays in the ventral cochlear nucleus.
Recordings were made in vitro from cochlear nuclei of Gunn rats, a strain with a recessive mutation that predisposes rats to hyperbilirubinemia at birth. Delays between shocks to the auditory nerve and earliest synaptic responses of the cochlear nuclear neurons were on average longer in Gunn rats than in heterozygotes. Injections of sulfonamide further increased average synaptic delays in jaundiced rats. Responses to injected current in rats were like those in mice.
Zhang
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Department of Neurophysiology, University of Wisconsin, Madison 53706.
Wickesberg
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Oertel
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D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003056:Cochlear Nerve / Q000187:drug effects / Q000503:physiopathology*; D004558:Electric Stimulation; D007565:Jaundice / Q000503:physiopathology*; D051381:Rats; D011911:Rats, Gunn / Q000502:physiology*; D011922:Rats, Mutant Strains / Q000502:physiology*; D011930:Reaction Time / Q000187:drug effects; D012249:Rhombencephalon / Q000187:drug effects / Q000503:physiopathology*; D013449:Sulfonamides / Q000494:pharmacology; D000159:Vestibulocochlear Nerve / Q000502:physiology
D013449:Sulfonamides