[Antibodies to glial fibrillary antigen as potential carriers of drugs for glial tumors].
Polyclonal monospecific antibodies to the glial fibrillar antigen of the brain (GFA) and, as controls, antibodies not possessing specific tendency were injected intravenously separately into two groups of rats with glioblastomas transplanted into the brain. The immunoenzymatic method was used to study the content of the injected antibodies in tissue extracts collected from the zone of the glioblastoma, brain matter and other organs 2, 20, and 48 hours after the injection. It was established that polyclonal monospecific antibodies to GFA accumulate selectively in the zone of the glioblastoma. The use of antibodies to GFA for selective transport of medicinal agents to malignant glial tumors must be evaluated in further studies.
Obukhov
S K
SK
Kalashnikova
V V
VV
Khalanskiĭ
A S
AS
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000918:Antibody Specificity; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001921:Brain / Q000276:immunology; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology*; D005910:Glioma / Q000188:drug therapy* / Q000276:immunology; D000922:Immunotoxins / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D051381:Rats; D013997:Time Factors
D000906:Antibodies; D000970:Antineoplastic Agents; D005904:Glial Fibrillary Acidic Protein; D000922:Immunotoxins
Antitela k glial'nomu fibrilliarnomu antigenu kak potentsial'nye perenoschiki lekarstvennykh sredstv k glial'nym opukholiam.