A role for Lyt-2+ T cells in resistance to cutaneous leishmaniasis in immunized mice.
The role of Lyt-2+ T cells in immunologic resistance to cutaneous leishmaniasis was analyzed by comparing infection patterns in resistant C57BL/6 mice and susceptible BALB/c mice induced to heal their infections after sub-lethal irradiation or i.v. immunization, with similar mice treated in vivo with anti-Lyt-2 antibodies. Administration of anti-Lyt-2 mAb resulted in a dramatic reduction in the number of lymphoid cells expressing the Lyt-2+ phenotype. Such treatment led to enhanced disease in both resistant C57BL/6 and irradiated BALB/c mice, as assessed by lesion size, but did not affect the capacity of these mice to ultimately resolve their infections. In contrast, anti-Lyt-2 treatment totally blocked the induction of resistance in i.v. immunized mice. These results suggest, that Lyt-2+ T cells may play a role in immunity to a Leishmania major infection and that their relative importance to resistance may depend on how resistance is induced.
Farrell
J P
JP
Department of Pathobiology, University of Pennsylvania, Philadelphia 19104.
Muller
I
I
Louis
J A
JA
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000950:Antigens, Ly / Q000276:immunology; D000953:Antigens, Protozoan / Q000008:administration & dosage*; D005260:Female; D007113:Immunity, Innate / Q000528:radiation effects; D007275:Injections, Intravenous; D007896:Leishmaniasis / Q000276:immunology*; D008212:Lymphocyte Depletion; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010641:Phenotype; D011828:Radiation Chimera; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology* / Q000528:radiation effects
D000911:Antibodies, Monoclonal; D000950:Antigens, Ly; D000953:Antigens, Protozoan