title: Mouse epidermal growth factor concentrations are altered by gonadectomy and treatments with estradiol and progesterone.
abstract: In adult male and female mice we compared the epidermal growth factor (EGF) concentrations after gonadectomy and studied the effects of postgonadectomy treatments with estradiol and progesterone. In gonadectomized mice the mean concentration of EGF in the submandibular salivary gland (SMG) was (7-fold) higher in the females than the males. In the kidneys the males had (1.3-fold) higher levels of EGF than the females. Yet, gonadectomized males had higher plasma EGF levels and females higher urinary EGF concentrations. Estradiol treatment clearly decreased the EGF concentration in the SMG and increased it in urine and kidneys. Progesterone decreased male kidney EGF. Combined treatment with estradiol and progesterone increased the EGF concentration in the male urine and SMG, and decreased it in male kidneys.
authors: Children's Hospital, University of Helsinki, Finland.
authors: T
authors: T
authors: Tuomela
authors: L
authors: L
authors: Viinikka
authors: J
authors: J
authors: Perheentupa
mesh_terms: D000818:Animals; D002369:Castration; D004815:Epidermal Growth Factor / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007668:Kidney / Q000378:metabolism; D008297:Male; D051379:Mice; D011374:Progesterone / Q000494:pharmacology*; D012737:Sex Factors; D013363:Submandibular Gland / Q000378:metabolism
chemical_list: D011374:Progesterone; D004958:Estradiol; D004815:Epidermal Growth Factor