[Effects of nifedipine on pollen-antigen-induced bronchoconstriction in asthmatics].
The clinical effects of a calcium antagonist--nifedipine on Xinjiang local pollen sensitive asthmatics were reported. 15 asthmatics were studied in a randomized double blind fashion by observing the changes in ten parameters of pulmonary function test which includes FEV1, FEV1/FVC. FEF25-75, PEFR V50, V25, RawinSp, RawExp, SRaw and SGaw. Our study showed that premedication of nifedipine significantly attenuated the subsequent bronchoconstriction induced by pollen antigen and offered remarkable increase of PC20. The protecting effect was most distinct from 50 to 60 minutes after medication. It provides a new way of clinical applicability in asthma prophylaxis and treatment.
Zhang
X L
XL
D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000209:etiology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D011058:Pollen / Q000276:immunology; D011897:Random Allocation; D012129:Respiratory Function Tests
D009543:Nifedipine