title: Benign recurrent intrahepatic cholestasis. A report of 26 cases.
abstract: Benign recurrent intrahepatic cholestasis is characterized by attacks of cholestasis. The purpose of our study of 26 patients was to emphasize some features uncommonly or never reported in this disease: (a) in each patient, the attacks of cholestasis were stereotypic; (b) attacks of cholestasis were not associated with pruritus in 15% of our patients; (c) the occurrence of attacks of cholestasis during pregnancy or oral contraceptive use might be a fortuitous coincidence; (d) gallstones were found in several patients with benign recurrent intrahepatic cholestasis and might be present earlier than in the general population; (e) in some of our patients, during attacks of cholestasis, serum transaminases were very high, exceeding 15 times the upper limit of normal; (f) mild portal inflammatory infiltration was found in one third of our patients; (g) no treatment shortened the duration of cholestasis, and in a few patients, plasmapheresis seemed to diminish jaundice and improve biochemical disorders.
authors: Service d'Hépatologie, Hôpital Beaujon, Clichy, France.
authors: R
authors: R
authors: Brenard
authors: A P
authors: AP
authors: Geubel
authors: J P
authors: JP
authors: Benhamou
mesh_terms: D000328:Adult; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis / Q000628:therapy; D002792:Cholestyramine Resin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use; D010956:Plasmapheresis; D012008:Recurrence
chemical_list: D002792:Cholestyramine Resin; D010634:Phenobarbital