title: Enhancement of pancreatic carcinogenesis in hamsters fed a high-fat diet ad libitum and at a controlled calorie intake.
abstract: An enhancement of pancreatic cancer induced by N-nitrosobis-(2-oxopropyl)amine (BOP) was reported previously in Syrian hamsters fed high-fat diet following carcinogen treatment. The purpose of our research was to determine if this enhancement was due to the consumption of more calories by the hamsters fed the high-fat diet. Male hamsters were treated with a single injection of BOP (20 mg/kg body weight s.c.) at 8 weeks of age. One week later they started either on a low-fat diet (4.3% corn oil) or a high-fat diet (20.5% corn oil) that was fed until the end of the experiment at 92 weeks after BOP. Diets were fed either ad libitum or in a control-fed protocol. The control-fed groups had equivalent calorie intakes and were restricted slightly in comparison with the ad libitum-fed hamsters. BOP treatment reduced survival slightly but survival did not differ significantly in accordance with dietary assignment. Body weight was elevated in the hamsters fed high-fat diet ad libitum in comparison with those fed low-fat diet ad libitum. However, differences were not observed in hamsters fed low- and high-fat diets by the control-fed protocol. Pancreatic carcinogenesis was enhanced about 3- to 4-fold when hamsters were fed high-fat diet by either protocol. The degree of enhancement did not differ with the feeding regimen. However, the higher death rate with pancreatic cancer occurred earlier in the ad libitum-fed hamsters than in the control-fed hamsters.
authors: Eppley Institute for Research in Cancer, Omaha, Nebraska 68105-1065.
authors: D F
authors: DF
authors: Birt
authors: A D
authors: AD
authors: Julius
authors: L T
authors: LT
authors: White
authors: P M
authors: PM
authors: Pour
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced* / Q000209:etiology / Q000473:pathology; D000236:Adenoma / Q000139:chemically induced* / Q000209:etiology / Q000473:pathology; D000375:Aging; D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D004038:Diet, Reducing; D004041:Dietary Fats; D002149:Energy Intake; D005704:Gallbladder / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines; D010179:Pancreas / Q000254:growth & development / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000209:etiology / Q000473:pathology
chemical_list: D002273:Carcinogens; D004041:Dietary Fats; D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine