The efficacy of triclabendazole (Fasinex) against immature and adult Fasciola hepatica in experimentally infected cattle.
Eighteen Chinese cattle were experimentally infected with metacercariae of Fasciola hepatica and randomly assigned to 6 groups. Five groups of cattle were treated with a single oral dose of triclabendazole at a dose rate of 12 mg kg-1. At necropsy, the reduction in fluke burden compared with the untreated group was 85, 99.6, 99.8, 100 and 100% for cattle treated 2, 6, 8, 12 and 16 weeks after infection, respectively. Data are also presented on body weight changes during the experimental period and on serum gamma-GT activity in cattle from selected groups. Triclabendazole is considered to be safer and more efficacious than currently available fasciolicides in China.
Shi
F H
FH
Shanghai Institute of Animal Schistosomiasis, Chinese Academy of Agricultural Sciences.
Lin
B F
BF
Qian
C G
CG
Li
M
M
Fang
M B
MB
Ma
J L
JL
Shen
W
W
Wang
S W
SW
Jian
X L
XL
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001652:Bile Ducts / Q000473:pathology; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005210:Fasciola hepatica / Q000187:drug effects; D005211:Fascioliasis / Q000188:drug therapy / Q000662:veterinary*; D005704:Gallbladder / Q000473:pathology; D008099:Liver / Q000473:pathology; D011897:Random Allocation; D000077682:Triclabendazole; D015430:Weight Gain
D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole