[Interconnection of the composition, physico-chemical characteristics of lipids and viscosity of the nuclear membrane after administration of diazan (1,2-bis-diazoacetylethane) in vivo].
Studies were carried out of changes in lipids composition, their antioxidative activity (AOA) and oxidizability, as well as of the viscosity of different regions of the liver cells nuclear membrane after single injection of diasan (1,2-bis-diasoacetyletan) (class of diasoketones) possessing antitumor activity in the experiment. On the basis of the results obtained the state of membrane control system was analysed. In vivo injection of diasan was found to bring about changes in AOA--membrane viscosity interaction in the system as compared to the norm. These changes are due to distortion of AOA--lipids composition--oxidizability interaction at earlier times, and of lipids composition--membrane viscosity interaction at later times. The experimental data are discussed in terms of a theoretical model of functioning of this control system in response to stimulation. A number of hypotheses are advanced concerning the role of some interactions of the system for the cell metabolism in the norm and antitumor effect of diasan from the standpoint of the control system under consideration.
Mal'tseva
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Pal'mina
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NP
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003979:Diazonium Compounds / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D051379:Mice; D009685:Nuclear Envelope / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction; D014783:Viscosity
D000970:Antineoplastic Agents; D003979:Diazonium Compounds; D008563:Membrane Lipids; C000279:diazan
Vzaimosviaz' sostava, fiziko-khimicheskikh kharakteristik lipidov i viazkost' iadernoĭ membrany posle vvedeniia diazana (1,2-bis-diazoatsetilétana) in vivo.