Estrual cycle periodicity in hormone-independent tumor-bearing mice.
The periodicity of the estrual cycle in mice was studied by vaginal cytology during the growth of a hormone-independent mammary adenocarcinoma. A direct relationship between age progression and lengthening of estrual cycle was observed in control mice but not in tumor-bearing mice of the same age. These results suggest that hormone regulation of the estrual cycle may be affected in tumor-bearing hosts.
Vauthay
L G
LG
Experimental Cancer and Animal Care Division, Instituto de Oncología A. H. Roffo, Facultad de Medicina, Buenos Aires, Argentina.
de Bonaparte
Y P
YP
D000230:Adenocarcinoma / Q000503:physiopathology*; D000818:Animals; D004971:Estrus; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000503:physiopathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010507:Periodicity