title: Endoscopic sclerotherapy for portal hypertension due to extrahepatic obstruction: long-term follow-up.
abstract: Between 1982 and 1987, 43 patients with variceal bleeding due to extrahepatic portal obstruction were treated by repeated endoscopic injection sclerotherapy using 1% polidocanol intravariceally. This decreased rebleeding, as evidenced by a decrease in bleeding risk factor (BRF), mean transfusion requirement, and mean number of transfusions per patient per month of follow-up. Differences between pre- and postsclerotherapy parameters were significant (p less than 0.001). The varices were eradicated in 86% of patients. The mean sclerotherapy sessions required were 7.68 +/- 2.39 (SD). Complications were infrequent. Forty-three patients were followed from 5 to 68 months: cumulative survival was 97.7% and varices recurred in 16%. Sclerotherapy avoided a second operation in 21 postsurgical patients. Sclerotherapy for managing variceal bleeding due to extrahepatic portal obstruction is a reasonable alternative to surgery.
authors: Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi.
authors: D K
authors: DK
authors: Bhargava
authors: M
authors: M
authors: Dwivedi
authors: S
authors: S
authors: Dasarathy
authors: A
authors: A
authors: Arora
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003251:Constriction, Pathologic; D004724:Endoscopy; D004932:Esophageal and Gastric Varices / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology / Q000628:therapy*; D008297:Male; D011169:Portal Vein; D012008:Recurrence; D012597:Sclerosing Solutions / Q000627:therapeutic use*; D014652:Vascular Diseases / Q000150:complications*
chemical_list: D012597:Sclerosing Solutions