title: A new and highly sensitive immunohistologic diagnostic criterion for Sjögren's syndrome.
abstract: Immunohistologic investigation of the sublabial salivary glands of 65 surgical patients who were free of systemic disease (control) and 19 patients with Sjögren's syndrome resulted in a new diagnostic criterion for SS that was more disease-specific than the widely used lymphocytic focus score criterion. Our bivariate classification criterion, which is based on the percentages of IgA- and IgG-containing plasma cells, has a specificity of 95.4% and a sensitivity of 100%, while its overall percentage of misclassification is 3.6%. This immunohistologic diagnostic criterion results in a reduction of the percentage of false-positive diagnoses from 9% to 4.6%.
authors: Institute for Pathologic Anatomy, University of Nijmegen, The Netherlands.
authors: P C
authors: PC
authors: de Wilde
authors: L
authors: L
authors: Kater
authors: J P
authors: JP
authors: Baak
authors: J C
authors: JC
authors: van Houwelingen
authors: R J
authors: RJ
authors: Hené
authors: P J
authors: PJ
authors: Slootweg
mesh_terms: D000367:Age Factors; D016002:Discriminant Analysis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007159:Immunologic Tests; D010950:Plasma Cells / Q000276:immunology; D012469:Salivary Glands / Q000276:immunology / Q000473:pathology; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000473:pathology
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M