Synthesis and investigation of effects of 2-[4- [[(arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity relationships.
A series of 2-[4-[[[(substituted-phenyl)amino]carbonyl]amino]phenoxy]-2- methylpropionic acids and other substituted phenoxyacetic acids were synthesized and tested for their ability to reduce the affinity of hemoglobin for oxygen. 2-[4-[[[(3,4,5-trichlorophenyl)amino]carbonyl]amino]phenoxy]-2- methylpropionic acid was found to be the most potent compound known. Structure-activity relationships of the compounds synthesized are discussed.
Lalezari
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Organic Chemistry Laboratory, Montefiore Medical Center, Bronx, New York.
Lalezari
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D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006016:Glycolates / Q000138:chemical synthesis*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D015394:Molecular Structure; D010108:Oxyhemoglobins / Q000378:metabolism*; D010642:Phenoxyacetates / Q000138:chemical synthesis* / Q000494:pharmacology; D011422:Propionates / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D006016:Glycolates; D006454:Hemoglobins; D010108:Oxyhemoglobins; D010642:Phenoxyacetates; D011422:Propionates