Familial Crohn's disease in multiple siblings: no linkage to the HLA system.
We report five families with 3 or more children having Crohn's disease. In one family, 6 out of 11 siblings were affected. HLA haplotype study in affected children showed that the probability of random segregation was only 38 percent, making improbable a linkage between the histocompatibility locus and the development of Crohn's disease. However similar clinical patterns in siblings could suggest a genetic factor not linked to the HLA system.
Colombel
J F
JF
Clinique des Maladies de l'Appareil Digestif, CHU Lille, France.
Guillemot
F
F
Van Gossum
A
A
Dufossé
F
F
Cortot
A
A
Dupont
E
E
Paris
J C
JC
D000293:Adolescent; D000328:Adult; D003424:Crohn Disease / Q000235:genetics*; D003627:Data Interpretation, Statistical; D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011336:Probability
D006680:HLA Antigens