[Change in the number of epidermal growth factor receptors of hepatocytes during liver regeneration in rats].
The number of epidermal growth factor (EGF) receptors was determined for rat's hepatocytes under condition of their regeneratory proliferation, following a partial hepatectomy. In the normal hepatocytes two classes of EGF-receptors are distinguished, with high and low affinity, respectively. As early as 2 hours after the partial hepatectomy the total number of EGF-receptors sharply decreases, those with high affinity being not determined at all. The patterns of autophosphorylation of EGF-receptors with low affinity, examined in regenerating liver hepatocytes, remained the same as in the intact liver: their kinase activity was EGF-dependent, tyrosine residues of receptor molecules, with molecular mass equal to 150-170 kDa, underwent phosphorylation.
Ivashchenko
Iu D
IuD
Gut
I T
IT
Garmanchuk
L V
LV
Kulik
G A
GA
Vykorez
A I
AI
D000818:Animals; D004815:Epidermal Growth Factor / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism*; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D010766:Phosphorylation; D051381:Rats
D004815:Epidermal Growth Factor; D066246:ErbB Receptors
Izmenenie kolichestva retseptorov épidermal'nogo faktora rosta gepatotsitov pri regeneratsii pecheni u krys.