title: Trifluoperazine plasma levels and clinical response.
abstract: The authors studied 36 acutely psychotic inpatients who were diagnosed as having either a schizophrenic (N = 30) or other psychotic (N = 6) disorder. After a washout phase averaging 18 days, all patients were placed on trifluoperazine 5 mg orally twice a day. Plasma levels of trifluoperazine were obtained on days 11 and 15 of treatment and then compared with clinical response. After 2 weeks of treatment an inverted U-shaped relationship was found between change scores on the Brief Psychiatric Rating Scale and trifluoperazine plasma levels.
authors: Illinois State Psychiatric Institute, Chicago 60612.
authors: P G
authors: PG
authors: Janicak
authors: J I
authors: JI
authors: Javaid
authors: R P
authors: RP
authors: Sharma
authors: J E
authors: JE
authors: Comaty
authors: J
authors: J
authors: Peterson
authors: J M
authors: JM
authors: Davis
mesh_terms: D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000097:blood* / Q000188:drug therapy / Q000523:psychology; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D014268:Trifluoperazine / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D014268:Trifluoperazine