Increased temporal lobe glucose use in chronic schizophrenic patients.
Temporal lobe glucose metabolic rate was assessed in 21 off-medication patients with schizophrenia and 19 normal controls by positron emission tomography with 18F-deoxyglucose. Patients with schizophrenia had significantly greater metabolic activity in the left than the right anterior temporal lobe, and the extent of this lateralization was in proportion to the severity of psychopathology.
DeLisi
L E
LE
Department of Psychiatry, University of California, Irvine 92717.
Buchsbaum
M S
MS
Holcomb
H H
HH
Langston
K C
KC
King
A C
AC
Kessler
R
R
Pickar
D
D
Carpenter
W T
WT
Morihisa
J M
JM
Margolin
R
R
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D001931:Brain Mapping; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000378:metabolism*; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000378:metabolism*; D014055:Tomography, Emission-Computed
D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose