Mass spectrometric approaches in structural characterization of cephalosporins.
The mass spectrometric behaviour of five structurally different cephalosporins has been studied in detail by means of different ionization/desorption methods (electron impact, fast atom bombardment, desorption chemical ionization, laser-induced vaporization) and metastable ion studies (linked scans and mass-analysed ion kinetic energy spectrometry). The best results were obtained by fast atom bombardment mass spectrometry, leading to both molecular ions and fragment ions diagnostic for structural identification.
Scandola
M
M
Glaxo S.p.A., Richerche e Sviluppo, Verona, Italy.
Tarzia
G
G
Gaviraghi
G
G
Chiarello
D
D
Traldi
P
P
D002511:Cephalosporins / Q000032:analysis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D013058:Mass Spectrometry
D002511:Cephalosporins