Deoxycoformycin antagonizes ischemia-induced neuronal degeneration.
Deoxycoformycin, a potent and specific adenosine deaminase antagonist, reduced ischemic hippocampal damage and the associated hypermotility in Mongolian gerbils. Cerebral ischemia was induced by a bilateral 5 min occlusion of the carotid arteries. Deoxycoformycin (500 micrograms/kg IP), administered 15 min prior to ischemia, prevented the increase in locomotor activity normally observed with this model and significantly reduced the ischemia-induced damage to CA1 hippocampal neurons. The results suggest that deoxycoformycin may be useful in the prevention of brain damage due to cerebral ischemia.
Phillis
J W
JW
Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201.
O'Regan
M H
MH
D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D003070:Coformycin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D005849:Gerbillinae; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D008297:Male; D009700:Nucleoside Deaminases / Q000378:metabolism*; D015649:Pentostatin; D012263:Ribonucleosides / Q000627:therapeutic use*; D013997:Time Factors
D012263:Ribonucleosides; D003070:Coformycin; D015649:Pentostatin; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase