Effect of fluoroquinolones on the in-vitro proliferation of myeloid precursor cells.
The effects of three fluoroquinolones (ofloxacin, pefloxacin and rufloxacin) on the in-vitro proliferation of murine myeloid cells were studied. Their activity was compared with that of nalidixic acid and novobiocin. Therapeutic concentrations of quinolones do not affect the physiological course of myelopoiesis. Only very high concentrations of drug (greater than 70 mg/l) affect bone marrow cell growth producing a dose-dependent inhibition. Because quinolones are active on topoisomerase II from eukaryotic cells they can modulate mammalian cell growth.
Pessina
A
A
Institute of Medical Microbiology, University of Milan, Italy.
Neri
M G
MG
Muschiato
A
A
Mineo
E
E
Cocuzza
G
G
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D005260:Female; D006098:Granulocytes / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015242:Ofloxacin / Q000494:pharmacology; D015366:Pefloxacin / Q000494:pharmacology
D000890:Anti-Infective Agents; D015366:Pefloxacin; D015242:Ofloxacin