title: Transient increase in plasma catecholamines following hypertonic/hyperosmotic fluid administration in conscious rats.
abstract: Plasma norepinephrine and epinephrine levels were monitored to determine possible alterations of the sympathetic nervous system caused by hypertonic fluid administration. Iv infusion (3.5 ml/kg, 1 min) of 7.5% NaCl/6% Hespan transiently increased both plasma norepinephrine and epinephrine levels to 197 +/- 28% and 220 +/- 30% of control, respectively, at 1 min. These increases were no longer significant 5 or 15 min following infusion. A brief hypotension was also observed immediately following hypertonic fluid administration. Thus, prolonged sympathetic activation does not occur following hypertonic fluid infusion in normovolemic conscious rats.
authors: Department of Physiology, East Carolina University School of Medicine, Greenville, NC 27858-4354.
authors: R G
authors: RG
authors: Carroll
authors: G T
authors: GT
authors: Clark
authors: M E
authors: ME
authors: Whitehurst
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003243:Consciousness / Q000187:drug effects; D004837:Epinephrine / Q000097:blood*; D006982:Hypertonic Solutions / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D009638:Norepinephrine / Q000097:blood*; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects*
chemical_list: D006982:Hypertonic Solutions; D009638:Norepinephrine; D004837:Epinephrine