[Indicators of the advance and rate of progress of radiographic changes in patients with rheumatoid arthritis and their correlation with clinical and laboratory criteria].
In a double blind study with hydroxychloroquine sulphate used for treatment of rheumatoid arthritis the correlation of six X-ray criteria of progression of RA, based on calculation of the narrowing of the articular spaces and erosions (Sharp and Amos) and 23 clinical and laboratory criteria was assessed. Before treatment a satisfactory correlation of the majority of clinical and laboratory criteria with X-ray criteria was found. As after one-year treatment the majority of clinical criteria improved significantly and X-ray criteria did not differ significantly before and after treatment, the authors found very few correlations between changes of clinical and X-ray criteria, in particular after a dose of 20 mg/day. The X-ray criteria recommended by Sharp and Amos are not sensitive enough to be used for the evaluation of changes of the X-ray picture after one-year treatment with anti-rheumatic drugs which modify the course of RA. This applies in particular to more advanced cases.
Pavelka
K
K
Gatterová
J
J
Pavelka
K
K
Pelísková
Z
Z
Trnavský
K
K
D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D001175:Arthrography; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use
D006886:Hydroxychloroquine
Ukazatele pokrocilosti a rychlosti progrese rtg-zmĕn u nemocných revmatoidní artritidou a jejich korelace s klinickými a laboratorními kritérii.