title: Sclerotherapy for extrahepatic portal hypertension in childhood.
abstract: Ten children with extrahepatic portal hypertension who had major bleeding from esophageal varices were treated with sclerotherapy of esophageal varices by means of flexible fiberoptic endoscopy and intravenous sedation. Four had had no previous therapy, five had had previous surgery for variceal bleeding, and five had received propranolol orally. During therapy and follow-up monitoring of 1.4 to 7.1 years (mean 4.7 years), only two patients bled again from esophageal varices, one before complete obliteration of varices and one who temporarily defaulted on follow-up. The few complications were easily managed, and only three required any specific therapy. No child bled from gastric varices. Frequency of sclerotherapy sessions and quantity of sclerosant could be decreased with time, usually after 3 years of sclerotherapy, suggesting that the natural history of decreased bleeding with time in extrahepatic portal hypertension may be accelerated by sclerotherapy. Esophageal varices in children with extrahepatic portal hypertension may be treated safely with sclerotherapy, which is effective in preventing chronic and recurrent gastrointestinal bleeding.
authors: Division of Pediatric Gastroenterology, University of British Columbia, Vancouver, Canada.
authors: E
authors: E
authors: Hassall
authors: W E
authors: WE
authors: Berquist
authors: M E
authors: ME
authors: Ament
authors: J
authors: J
authors: Vargas
authors: S
authors: S
authors: Dorney
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004724:Endoscopy; D004932:Esophageal and Gastric Varices / Q000628:therapy*; D005260:Female; D005336:Fiber Optic Technology; D005500:Follow-Up Studies; D006471:Gastrointestinal Hemorrhage / Q000628:therapy*; D006801:Humans; D008297:Male; D012008:Recurrence; D012597:Sclerosing Solutions / Q000627:therapeutic use*
chemical_list: D012597:Sclerosing Solutions