title: Expression of the CD4 molecule on acute nonlymphocytic leukemia (ANLL) cell lines.
abstract: Mature and immature monocytes express the CD4 molecule similar to that expressed on lymphocytes. Since monocytes and cells of myeloid lineage are derived from a common progenitor, we studied a panel of nine myeloid leukemia cell lines for the expression of the CD4 molecule. We found that six of nine myeloid leukemia cell lines (U937, KG1-B, HL-60, THP-1, HEL 92.1.7, KMOE) expressed CD4, the exceptions being the erythroleukemia line K562, myeloblast line KG1-REV, and megakaryocytic line, CHRF-288. SDS-PAGE analysis of HL-60 cells immunoprecipitated with OKT4 showed the presence of a 55 kd molecule similar in weight to that seen on lymphocytes. These data suggest that some myeloid progenitor cells express the CD4 molecule and that the CD4 may have a broader distribution within hematopoietic cells.
authors: Division of Hematology/Oncology, Children's Hospital Research Foundation, Cincinnati, OH 45229.
authors: S
authors: S
authors: Neudorf
authors: C
authors: C
authors: DeLaat
authors: M
authors: M
authors: Jones
mesh_terms: D015704:CD4 Antigens / Q000032:analysis*; D002460:Cell Line; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology; D007947:Leukemia, Megakaryoblastic, Acute / Q000276:immunology; D007948:Leukemia, Monocytic, Acute / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000276:immunology*; D015473:Leukemia, Promyelocytic, Acute / Q000276:immunology; D009000:Monocytes / Q000276:immunology*
chemical_list: D015704:CD4 Antigens