Epidermal growth factor receptor not equal to nerve growth factor.
I am perplexed by the authors' complete lack of definition of neurotrophic factors. The agents Butcher and Woolf want to blame are neurite promoting factors, not neurotrophic factors. Treatment of Alzheimer's disease with NGF antagonists might instead exacerbate the death of both basal forebrain neurons and their cortical target neurons, accelerating the progress of dementia.
Williams
L R
LR
CNS Diseases Research, Upjohn Company, Kalamazoo, MI 49001.
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000503:physiopathology; D066246:ErbB Receptors / Q000187:drug effects*; D006801:Humans; D009414:Nerve Growth Factors / Q000037:antagonists & inhibitors*
D009414:Nerve Growth Factors; D066246:ErbB Receptors