Modification of Catharanthus roseus alkaloids: a lactone derived from 17-deacetylvinblastine.
A spirolactone with anti-tumor activity is formed during the reaction of paraformaldehyde with 17-deacetylvinblastine. The compound was identified by NMR techniques. The chemotherapeutic activity was assessed.
De Bruyn
A
A
Verzele
M
M
Dejonghe
J P
JP
Bhushana Rao
K S
KS
Collard
M P
MP
Trouet
A
A
Hannart
J
J
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007783:Lactones / Q000302:isolation & purification; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008811:Mice, Inbred DBA; D014747:Vinblastine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; C052416:4-desacetylvinblastine; D014747:Vinblastine