title: The effects of altered strain environments on bone tissue kinetics.
abstract: This study defines the alteration in bone tissue kinetics responsible for the "adaptive remodeling" response to altered strain environments. Adult beagle dogs were separated into three experimental groups: ulnar osteotomy, ulnar osteotomy with fracture fixation plate spanning the gap and sham surgery. Four sets of double fluorochrome labels were administered. Prior to sacrifice at 1, 3, and 6 months, strains were measured through rosette strain gages on the cranial and caudal surfaces of the intact radius. Histomorphometric analysis indicated that the increased bone mass in response to elevated strain results from increased activation frequency of modeling with more sites undergoing formation processes than resorption processes on periosteal and endocortical surfaces. Increased remodeling activation did not lead to increased bone mass. There was no evidence that elevated strain changes the individual vigor of osteoclasts or osteoblasts, or that the sigma period was altered by elevated strain.
authors: Department of Anatomy, West Virginia University Health Sciences, Morgantown 26506.
authors: D B
authors: DB
authors: Burr
authors: M B
authors: MB
authors: Schaffler
authors: K H
authors: KH
authors: Yang
authors: D D
authors: DD
authors: Wu
authors: M
authors: M
authors: Lukoschek
authors: D
authors: D
authors: Kandzari
authors: N
authors: N
authors: Sivaneri
authors: J D
authors: JD
authors: Blaha
authors: E L
authors: EL
authors: Radin
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001846:Bone Development; D001860:Bone Plates; D004285:Dogs; D007700:Kinetics; D008297:Male; D010027:Osteotomy; D011884:Radius / Q000032:analysis; D013314:Stress, Mechanical; D013312:Stress, Physiological / Q000378:metabolism* / Q000503:physiopathology; D014457:Ulna / Q000378:metabolism* / Q000601:surgery