[Effects of sodium oxybutyrate on the level of catecholamines and serotonin and monoamine oxidase activity in patients with alcoholism].
Sodium salt of gamma-hydroxybutyric acid (Na-GHB) was administered to 37 drug-free alcoholic men in placebo controlled study. The psychotropic effect was evaluated using psychometric scale of 4 ranges. Changes in plasma levels of epinephrine, norepinephrine, dopamine, serotonin and platelet MAO-B activity were assessed. The psychotropic effect was observed in 27 (76%) patients. The baseline of dopamine concentration was significantly correlated with the expression of psychotropic effect. Na-GHB decreased dopamine concentration in responders. The possible involvement of dopaminergic system in the realization of psychotropic effect of Na-GHB was discussed.
Treskov
V G
VG
Krashkina
I I
II
Tsirenina
M L
ML
Koltovaia
N A
NA
Nikol'skaia
G V
GV
Baturin
A K
AK
Gapparov
M M
MM
Mel'nik
E I
EI
Maĭskiĭ
A I
AI
D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000188:drug therapy*; D001792:Blood Platelets / Q000201:enzymology; D002395:Catecholamines / Q000097:blood*; D004298:Dopamine / Q000097:blood; D004837:Epinephrine / Q000097:blood; D006801:Humans; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D008995:Monoamine Oxidase / Q000097:blood*; D009638:Norepinephrine / Q000097:blood; D012701:Serotonin / Q000097:blood*; D012978:Sodium Oxybate / Q000494:pharmacology / Q000627:therapeutic use*
D002395:Catecholamines; D006885:Hydroxybutyrates; D012701:Serotonin; D012978:Sodium Oxybate; D008995:Monoamine Oxidase; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
Vliianie natriia oksibutirata na urovni katekholaminov, serotonina i aktivnost' monoaminoksidazy u bol'nykh alkogolizmom.