Malic enzyme type VII isoenzyme as an indicator of suramin resistance in Trypanosoma evansi.
This study analysed the suramin sensitivity of 29 stocks of Trypanosoma evansi isolated from Egypt, Sudan, and Indonesia and compared the results with the isoenzyme banding patterns of 20 soluble enzymes in these stocks of T. evansi. The results showed that the type VII banding pattern of malic enzyme was found only in T. evansi stocks which were highly resistant to suramin.
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Centre for Tropical Veterinary Medicine, Midlothian, Scotland.
Jones
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Payne
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D000818:Animals; D004351:Drug Resistance; D004534:Egypt; D005260:Female; D007214:Indonesia; D007527:Isoenzymes / Q000032:analysis*; D008291:Malate Dehydrogenase / Q000032:analysis*; D051379:Mice; D013397:Sudan; D013498:Suramin / Q000494:pharmacology* / Q000627:therapeutic use; D014345:Trypanosoma / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D014352:Trypanosomiasis / Q000188:drug therapy / Q000469:parasitology*
D007527:Isoenzymes; D013498:Suramin; D008291:Malate Dehydrogenase