[Ultrastructural and immunocytochemical study on human silent pituitary adenomas].
16 cases of silent pituitary adenomas were studied with immunoelectron microscopy using protein A-gold probes and were subtyped on their ultrastructural appearances and immunocytochemical reactivity. 2 cases were identified as sparsely granulated PRL adenomas, comprising numerous PRL-positive cells. In 2 acidophil stem cell adenomas were detected GH- and PRL-producing cells, though fewer in number. No hormone activity was found in the secretory granules of 3 oncocytomas and 9 undifferentiated cell adenomas. The morphological features of various silent pituitary adenomas are described and their clinical implications are discussed.
Zhou
X J
XJ
D000236:Adenoma / Q000378:metabolism / Q000648:ultrastructure*; D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D015175:Prolactinoma / Q000648:ultrastructure
D013006:Growth Hormone