CT-SPECT fusion to correlate radiolabeled monoclonal antibody uptake with abdominal CT findings.
To enhance the information provided by computed tomography (CT) and single photon emission computed tomography (SPECT) performed with radiolabeled, anti-carcinoembryonic antigen monoclonal antibody (MoAb), the authors performed fusion of these types of images from eight subjects with suspected colorectal adenocarcinoma. Section thickness and pixel size of the two studies were matched, coordinates of corresponding points from each study were identified, and CT sections were translated, rotated, and reprojected to match the corresponding SPECT scans. The CT-SPECT fusion enabled identification of anatomic sites of tumor-specific MoAb accumulation in four cases, showed non-specific MoAb accumulation in two, and helped confirm information only suggested by the two studies separately in one.
Kramer
E L
EL
Nuclear Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Noz
M E
ME
Sanger
J J
JJ
Megibow
A J
AJ
Maguire
G Q
GQ
D000230:Adenocarcinoma / Q000175:diagnosis*; D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen / Q000276:immunology*; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007205:Indium Radioisotopes; D008297:Male; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D007205:Indium Radioisotopes