Observation of activity of IL-2 produced by mononuclear cells in tumor draining lymph-node.
The activity of IL-2 produced by mononuclear cells in draining lymph-onde and peripheral blood from patients with cancer was investigated. It was found that, though the activity of IL-2 produced by peripheral blood mononuclear cells from these patients became much lower, the activity of IL-2 produced by draining lymph node mononuclear cells from the same donors showed no decline, in contrast to non-malignant patients and healthy controls. What is more, the NK cells of tumor draining lymph-nodes responded as strong to xenogenous IL-2 as those of draining lymphnodes from patients with non-malignant disease. The results suggested that some of the immune functions of tumor draining lymph-node mononuclear cells might be more stable than those of peripheral blood mononuclear cells in patients suffering from cancer, and that local injection of xenogenous IL-2 might enhance the anti-cancer activity of tumor draining lymph-node.
Fang
J M
JM
Bi
A H
AH
D001943:Breast Neoplasms / Q000276:immunology*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D013274:Stomach Neoplasms / Q000276:immunology*
D007376:Interleukin-2