[Histopathologic observation on the therapeutic effect of Tripterygium wilfordii in treating experimental allergic encephalomyelitis].
The Tripterygium wilfordii (TW) was used to treat experimental allergic encephalomyelitis (EAE) in guinea-pig. The morphological change was observed by using light microscope. Lymphocytic histochemical staining was performed on the spinal cord from EAE in guinea-pig. The results were: The incidence of inflammatory reaction, neuraxial swelling, break and neuronal necrosis in the treatment group was lower than that in the control group (P less than 0.01-0.005); the variation of incidence of neurofibrillar demyelinating in the treatment group was smaller than that in the control group (P less than 0.025). The result of ANAE and ALP staining for lymphocytes in the spinal cord from EAE was T-cell. It showed TW could inhibit the allergic action and decrease tissular injury.
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D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology; D006168:Guinea Pigs; D008297:Male; D013116:Spinal Cord / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects
D004365:Drugs, Chinese Herbal