title: Analgesic and anti-inflammatory effects of some benzanilides.
abstract: Analgesic and anti-inflammatory effects of N-(p-ethoxyphenyl)-2,6-dihydroxybenzamide (1), N-(p-ethoxyphenyl)-2,6-diacetoxybenzamide (2), N-(p-ethoxyphenyl)-2,5-dihydroxybenzamide (3), and N-(p-ethoxyphenyl)-2,5-diacetoxybenzamide (4) have been investigated in mice and rats. The analgesic effect of 2 on acetic acid-induced writhing was found to be stronger than that of aspirin, whereas that of 1, 3, and 4 was weaker than that of aspirin. In inflammatory studies, 1-4 showed inhibition of formaldehyde-induced paw swelling (edema). The effects of 1-3 were more potent than that of aspirin, 1 being the most potent. The potency of 4 was almost equal to that of aspirin.
authors: Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors: E
authors: E
authors: Oskay
authors: F
authors: F
authors: Aksu
authors: M I
authors: MI
authors: Cingi
authors: K
authors: K
authors: Erol
authors: M
authors: M
authors: Fidan
mesh_terms: D000813:Anilides / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D008297:Male; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000813:Anilides; D000894:Anti-Inflammatory Agents, Non-Steroidal