Effects of intracerebral estradiol on the dorsal immobility response in the rat.
The effects of intracerebral implants of 17 beta estradiol and cholesterol in five brain regions were tested on the duration of the dorsal immobility response in ovariectomized female rats. The dorsal immobility response was significantly prolonged by 4-hr implants of 17 beta estradiol in the dorsal striatum and nucleus accumbens, but not in the cortex, the globus pallidus, or the substantia nigra pars compacta. These data further support previous evidence that estradiol acts directly on the striatum to affect behavior in the rat.
Van Hartesveldt
C
C
Psychology Department, University of Florida, Gainesville 32611.
Cottrell
G A
GA
Meyer
M E
ME
D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects*; D001921:Brain / Q000033:anatomy & histology; D004343:Drug Implants; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007103:Immobilization; D010052:Ovariectomy; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*
D004343:Drug Implants; D004958:Estradiol