Effect of diazepam on electroacupuncture-induced changes in regional gamma-aminobutyric acid of the rat central nervous system.
Electroacupuncture-induced analgesia (EAA), as assessed in terms of tail flick latency in adult male albino rats, was reduced or completely withdrawn by co-treatment of diazepam with electroacupuncture (EA) (10 Hz, 1 volt), although diazepam (5-20 mg/kg, i.p.) alone had no analgesic effect. Further, it was found that only the gamma-aminobutyric acid (GABA) system of thalamus and pons-medulla regions were involved in EAA. The EA-induced inhibition of GABAergic activity in the thalamus and pons-medulla was disinhibited when diazepam was pre-administered to rats treated with a single EA and reduced the EAA.
Chakrabarti
S
S
Department of Biochemistry, University of Calcutta, India.
Poddar
M K
MK
D015667:Acupuncture Analgesia; D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D003975:Diazepam / Q000494:pharmacology*; D008297:Male; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D003975:Diazepam