Sleep apnea in Alzheimer's disease.
Mental deterioration accompanying sleep apnea has been noted frequently. Because sleep apnea increases with age, such deficits raise the possibility that dementia in the elderly could be related to sleep apnea. In this study we investigated this possibility cross-sectionally by comparing respiration during sleep in 28 patients with Alzheimer's disease (AD) and 25 nondemented controls. We hypothesized that higher levels of sleep apnea would be present in AD patients. Our results indicated no significant differences between AD patients and controls but those few AD patients who desaturated during sleep experienced morning confusion. The findings imply that AD and sleep apnea are two separate conditions which may still interact in the aged.
Bliwise
D L
DL
Department of Psychiatry and Behavioral Science, Stanford University Medical School, CA 94305.
Yesavage
J A
JA
Tinklenberg
J R
JR
Dement
W C
WC
D000368:Aged; D000375:Aging / Q000502:physiology; D000544:Alzheimer Disease / Q000150:complications*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000453:epidemiology