Isolation of isoflavonoids possessing antioxidant activity from the fermentation broth of Streptomyces sp.
Three antioxidant isoflavonoids characterized as 4',7,8-trihydroxyisoflavone (1), 3',4',7-trihydroxyisoflavone (2) and 8-chloro-3',4',5,7-tetrahydroxyisoflavone (3) were isolated from the cultured broth of Streptomyces sp. OH-1049. Among them, 3 is a novel isoflavonoid possessing a chlorine atom in the molecule. In in vitro studies, these antibiotics were found to possess antioxidant activity whereas showed almost no cytocidal activities against HeLa S3 cells.
Komiyama
K
K
Kitasato Institute, Tokyo, Japan.
Funayama
S
S
Anraku
Y
Y
Mita
A
A
Takahashi
Y
Y
Omura
S
S
Shimasaki
H
H
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005419:Flavonoids / Q000302:isolation & purification*; D006367:HeLa Cells / Q000187:drug effects; D007529:Isoflavones / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D008826:Microbial Sensitivity Tests; D051381:Rats; D011919:Rats, Inbred Strains; D013302:Streptomyces / Q000145:classification; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D005419:Flavonoids; D007529:Isoflavones; C061216:8-chloro-3',4',5,7-tetrahydroxyisoflavone; C061214:4',7,8-trihydroxyisoflavone; C061213:3',4',7-trihydroxyisoflavone