title: [New heterocyclic derivatives with germicidal activity. VI. Synthesis and activity of new 2-benzoxazoyl-2'-furanes and -thiophenes variously substituted in 5 and 5' positions].
abstract: Seventeen derivatives of 2'-furyl-2-benzoxazole and three derivatives of 2'-thienyl-2-benzoxazole, having different substituents in the benzene moiety (position 5) and in the furanic or thiophenic ring (position 5'), are described, with the aim of studying antibacterial and antimycotic structure-activity relationships. None of the compounds show an important antibacterial and/or antimycotic activity, when tested against nine bacteria and Candida albicans cultures; in any case it was much lower than that previously reported for the corresponding benzimidazoles. It seems that the = NH group of the imidazole ring, which is absent in the benzoxazole derivatives, might be important for the biological activity of this class of compounds.
authors: Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università Degli Studi di Perugia, Italia.
authors: G
authors: G
authors: De Meo
authors: M
authors: M
authors: Pedini
authors: A
authors: A
authors: Ricci
authors: L
authors: L
authors: Bastianini
authors: T
authors: T
authors: Sposini
authors: P
authors: P
authors: Jacquignon
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001583:Benzoxazoles; D005663:Furans; D013876:Thiophenes
vernacular_title: Nuovi derivati eterociclici ad attività germicida. VI. Sintesi ed attività di nuovi 2-benzossazolil-2'-furani e-tiofeni, variamente sostituiti in 5 e 5'.