Abolishment of metastasis formation by murine tumor cells transfected with "foreign" H-2K genes.
High metastatic, low immunogenic Lewis lung carcinoma clones express low levels of H-2Kb major histocompatibility complex antigens. These cells metastasize spontaneously in mice with C57BL/6 genetic background possessing the H-2Db locus. Transfection of different H-2K genes abrogates metastasis in H-2K, H-2D compatible mice and in C57BL/6 recipients. The transfected cells are potent inducers of H-2K-restricted and alloreactive cytotoxic lymphocytes that kill H-2K-positive cells and cross-react with parental nontransfected cells.
Gelber
C
C
Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Plaksin
D
D
Vadai
E
E
Feldman
M
M
Eisenbach
L
L
D000818:Animals; D003429:Cross Reactions; D006183:H-2 Antigens / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014162:Transfection
D006183:H-2 Antigens