The effect of a cystamine derivative, bis[2-(E-2-hexenoylamino)ethyl] disulfide, on rat platelet aggregation.
Bis[2-(E-2-alkenoylamino)ethyl] disulfides (compds. I), synthesized from cystamine and 2-trans fatty acids, inhibited collagen-induced rat and rabbit platelet aggregation. The most potent compound was bis[2-(E-2-hexenoylamino)ethyl] disulfide (compd. I-1), and this compound suppressed thromboxane B2 formation from arachidonic acid in rat platelets. The results suggested that compd. I-1 has an inhibitory effect on cyclooxygenase.
Mimura
T
T
Nakajima
H
H
Tsujikawa
K
K
Haruyama
M
M
Lee
B G
BG
Kohama
Y
Y
Kohda
I
I
Iwai
M
M
D000475:Alkenes / Q000138:chemical synthesis*; D000818:Animals; D003538:Cystamine / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000031:analogs & derivatives; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep
D000475:Alkenes; D010975:Platelet Aggregation Inhibitors; C061601:bis(2-(2-hexenoylamino)ethyl) disulfide; D003538:Cystamine