[Antioxidant properties of benzofurocaine, phenycaberan and orthophen].
The antioxidant properties of benzofurocaine, phenycaberan, crithophen, alpha-tocopherol and ionol were evaluated by inhibition of oxygen absorption by liposomes from egg phosphatidylcholine induced by the addition of an prooxidant. The activity of the tested agents at inhibition of Fe2+-ascorbater-initiated oxidation decreases in the order: ionol, benzofurocaine, phenycaberan, orthophen, alpha-tocopherol; emine-initiated (EDTA-independent) oxidation of phosphatidylcholine is inhibited only by ionol, orthophen and alpha-tocopherol. Phenycaberan exerts no effect on oxidation and benzofurocaine increases the rate of emine-initiated absorption of oxygen. Thus, benzofurocaine, phenycaberan and orthophen may be referred to as selective inhibitors of Fe2+-initiated peroxidation of phosphatidylcholine.
Lebedev
A V
AV
Kuz'min
A V
AV
Levitskiĭ
D O
DO
Stepaniuk
G I
GI
D000779:Anesthetics, Local / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001572:Benzofurans / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D004008:Diclofenac / Q000494:pharmacology*; D008081:Liposomes / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology
D000779:Anesthetics, Local; D000975:Antioxidants; D001572:Benzofurans; D008081:Liposomes; D010713:Phosphatidylcholines; D014810:Vitamin E; D004008:Diclofenac; D002084:Butylated Hydroxytoluene; C015212:fenicoberan; C040205:benzofurocaine; D010100:Oxygen
Antioksidantnye svoĭstva benzofurokaina, fenikaberana i ortofena.