title: The absence of direct antimicrobial activity in extracts of cytotoxic lymphocytes.
abstract: An important mechanism used by the immune system in resisting infections by intracellular pathogens is the destruction of host cells by cytolytic lymphocytes. Whether these lymphocytes display a more direct antimicrobial action remains unclear. We have attempted to answer this question by testing extracts of cytolytic lymphocytes, prepared by cell fractionation, against three bacterial species - Escherichia coli, Salmonella typhimurium, and Listeria monocytogenes. We also tested these extracts against two viruses - pseudorabies virus and vesicular stomatitis virus. The extracts showed negligible activity against the test organisms under the conditions used.
authors: Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021.
authors: S
authors: S
authors: Joag
authors: J D
authors: JD
authors: Young
mesh_terms: D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D002457:Cell Extracts / Q000494:pharmacology*; D002458:Cell Fractionation; D002460:Cell Line; D015169:Colony Count, Microbial; D013602:T-Lymphocytes, Cytotoxic / Q000032:analysis / Q000276:immunology*; D013997:Time Factors; D014020:Tissue Extracts / Q000494:pharmacology*; D014780:Viruses / Q000187:drug effects / Q000254:growth & development
chemical_list: D002457:Cell Extracts; D014020:Tissue Extracts