Myoglobinuria exacerbates ischemic renal damage in the dog.
The effects of intramuscular glycerol on ischemic acute renal failure was investigated in dogs. Anesthetized dogs received a bilateral 120-min renal artery obstruction (RAO) alone, RAO plus 5 ml/kg of 50% glycerol or RAO plus 5 ml/kg of 75% glycerol. Control groups received the glycerol injection, but not RAO. Renal histopathology was minimal in dogs receiving glycerol alone. In RAO dogs, those receiving 50% glycerol showed diffuse acute tubular necrosis (ATN), while those receiving 75% glycerol had severe ATN with extreme mortality. Changes in serum creatinine, creatinine clearance, and fractional excretion of sodium were consistent with the histopathologic changes. We conclude that myoglobinuria, of a degree insufficient to cause renal failure itself, can interact with renal ischemia to significantly exacerbate the renal damage produced.
Mandal
A K
AK
Division of Nephrology, VA Medical Center, Dayton, Ohio.
Davis
J B
JB
Bell
R D
RD
Miller
J M
JM
D058186:Acute Kidney Injury / Q000209:etiology*; D000818:Animals; D003404:Creatinine / Q000097:blood; D004285:Dogs; D005990:Glycerol / Q000008:administration & dosage; D006400:Hematocrit; D007273:Injections, Intramuscular; D007511:Ischemia / Q000150:complications* / Q000473:pathology; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D007683:Kidney Tubular Necrosis, Acute / Q000209:etiology / Q000473:pathology; D008297:Male; D008657:Metabolic Clearance Rate; D009212:Myoglobinuria / Q000139:chemically induced / Q000150:complications* / Q000473:pathology; D009994:Osmolar Concentration; D012206:Rhabdomyolysis; D014556:Urine
D003404:Creatinine; D005990:Glycerol