title: Synthesis and anti-tumour activity of topologically-related analogues of flavoneacetic acid.
abstract: A number of structural analogues of the solid tumour active drug flavoneacetic acid have been prepared and evaluated for in vivo activity against colon 38 adenocarcinoma, in order to extend the limited structure-activity relationships available for compounds with this type of activity. Apart from the fused ring analogue xanthenone-4-acetic acid, structural and electronic modifications of the nucleus led to inactive compounds, suggesting the existence of quite narrow structure-activity relationships.
authors: Cancer Research Laboratory, University of Auckland School of Medicine, New Zealand.
authors: G J
authors: GJ
authors: Atwell
authors: G W
authors: GW
authors: Rewcastle
authors: B C
authors: BC
authors: Baguley
authors: W A
authors: WA
authors: Denny
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000138:chemical synthesis* / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids; C049328:flavone acetic acid