Post exposure studies with human diploid cell rabies vaccine and purified chick embryo cell vaccine: comparative serological responses in man.
Rabies-neutralising antibody responses to human diploid cell strain rabies vaccine (HDCSV) and purified chick embryo cell vaccine (PCECV) were studied in 125 patients previously exposed to rabid animals having received 3, 5 and 6 doses on days 0, 3, 7, 14, 30 and 90. Antibody response was significantly higher (P less than 0.05) with HDCSV than PCECV in all subjects irrespective of their sex and age group. Three doses on day 0, 3, 7 given for post-exposure rabies prophylaxis to class I patients with a negligible risk elicited antibody titres significantly higher than the minimum protective level required (0.5 I.U./ml); the mean response was greater than 15 I.U./ml in the case of PCECV and greater than 32 I.U./ml in the case of HDCSV. The use of PCECV is cost-effective and suggested for use in developing countries.
Madhusudana
S N
SN
Rabies Research Centre, Central Research Institute, Kasauli, India.
Tripathi
K K
KK
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002642:Chick Embryo; D002648:Child; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D009500:Neutralization Tests; D011818:Rabies / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*; D012737:Sex Factors
D000914:Antibodies, Viral; D011819:Rabies Vaccines