Cryopreserved saphenous vein homografts for femoral-distal vascular reconstruction.
Cryopreserved saphenous vein homografts may serve as an alternative for femoral distal bypass conduits when suitable endogenous vein is not available. In a preliminary study, 6 patients underwent femoral distal bypass for limb salvage with cryopreserved saphenous vein with patency in 2 patients at 18 and 20 months, respectively. One graft, occluded at 14 months, was salvaged with thrombolytic therapy and percutaneous angioplasty, and is patent 7 months post intervention. Occlusion occurred in 3 grafts at 1 day, 7 days and 4 months, respectively. Reasons for reduced patency of cryopreserved grafts are related to destruction of the cellular components and fibrosis as a result of the cryopreservation and poor distal run-off present in these patients. Due to lower patency as compared to autogenous vein grafts, cryopreserved veins should be reserved for limb salvage when no autogenous vein is available for revascularization.
Sellke
F W
FW
Division of Cardiothoracic Surgery, University of Iowa Hospitals and Clinics, Iowa City.
Meng
R L
RL
Rossi
N P
NP
D000328:Adult; D000368:Aged; D001807:Blood Vessel Prosthesis; D015925:Cryopreservation; D005263:Femoral Artery / Q000601:surgery*; D006083:Graft Occlusion, Vascular / Q000209:etiology; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D012501:Saphenous Vein / Q000637:transplantation*; D014021:Tissue Preservation; D014654:Vascular Patency