Influence of guar on serum lipids in patients with hyperlipidaemia.
The antihyperlipidaemic effect of a guar preparation which absorbs a particularly large amount of water has been examined in 13 patients with Type II hyperlipidaemia. A 30-day pre-treatment phase was followed by 60 days of treatment with 4 g guar dissolved in 200-ml liquid at each meal-time (total guar 12 g/day), and a 60-day post-treatment observation period. Routine other clinical blood tests were performed 30, 15 or 0 days before treatment, 15, 30 and 60 days after the start of treatment, and 30 and 60 days after its end. Total cholesterol fell by 0.85 mmol.l-1, from a pre-treatment concentration of 7.4 mmol.l-1 to a treatment value of 6.5 mmol.l-1, and LDL-cholesterol fell by 0.64 mmol.l-1, from 5.5 mmol.l-1 to a treatment value of 4.8 mmol.l-1. There was no significant change in triglyceride and VLDL concentrations during the study. A slight but significant fall in HDL-cholesterol was seen. The sole adverse effect was occasional intestinal discomfort.
Kirsten
R
R
Clinical Pharmacology and Central Laboratory, University of Frankfurt, Federal Republic of Germany.
Domning
B
B
Nelson
K
K
Nemeth
K
K
Oremek
G
G
Hübner-Steiner
U
U
Speck
U
U
D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005685:Galactans / Q000627:therapeutic use*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D008055:Lipids / Q000097:blood*; D008297:Male; D008351:Mannans / Q000627:therapeutic use*; D008875:Middle Aged; D053149:Plant Gums; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005685:Galactans; D008055:Lipids; D008351:Mannans; D053149:Plant Gums; D014280:Triglycerides; D002784:Cholesterol; C007894:guar gum