Carnitine and deoxycarnitine concentration in rat tissues and urine after their administration.
Administration of L-carnitine to rats was followed by an increase of deoxycarnitine in urine. Conversely, administration of deoxycarnitine caused an increase of carnitine. The latter treatment also produced a transient but significant diminution of L-carnitine in heart, skeletal muscle and kidney, but not in liver and plasma. Administration of D-carnitine to rats previously loaded with deoxycarnitine significantly depleted the elevated deoxycarnitine concentration in skeletal muscle and kidney while increasing it in plasma. These results suggest that the tissue exchange between L-carnitine and deoxycarnitine, already demonstrated in vitro, occurs also in vivo.
Sartorelli
L
L
Dipartimento di Chimica Biologica, CNR, Padova, Italy.
Mantovani
G
G
Ciman
M
M
D000818:Animals; D001622:Betaine / Q000493:pharmacokinetics / Q000031:analogs & derivatives; D002331:Carnitine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D007668:Kidney / Q000032:analysis; D009132:Muscles / Q000032:analysis; D009206:Myocardium / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D001622:Betaine; C002889:gamma-butyrobetaine; D002331:Carnitine