A complex t(3;8;17) involving breakpoint 8p11 in a case of M5 acute nonlymphocytic leukemia with erythrophagocytosis.
The t(8;16)(p11;p13) is a recently described new chromosome rearrangement of acute nonlymphocytic leukemia (ANLL). It appears to be specifically associated with acute monoblastic (AML-M5) or unusual myelomonocytic leukemia with prominent erythrophagocytosis in the leukemic cells. A complex t(3;8;17)(q27;p11;q12) is reported in a case of acute monoblastic leukemia with erythrophagocytosis. Sixteen cases of this t(8;16) and two other variant translocations are reviewed. The pathogenetic mechanism of the variant translocations is discussed, suggesting that the der(8) is a consistent recombinant.
Bertheas
M F
MF
Departement d'Hématologie, Immunologie et Cytogénétique, Centre Hospitalier et Universitaire de Saint-Etienne, France.
Jaubert
J
J
Vasselon
C
C
Reynaud
J
J
Pomier
G
G
Le Petit
J C
JC
Hagemeijer
A
A
Brizard
C P
CP
D002871:Chromosome Banding; D002886:Chromosomes, Human, Pair 17; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D010587:Phagocytosis; D014178:Translocation, Genetic