[Neonatal alloimmunothrombocytopenia--effect of combination therapy consisting of i.v. immunoglobulin administration and transfusion of PLA1-negative maternal thrombocytes].
Two newborn infants with severe alloimmunothrombocytopenia due to maternal immunization against fetal PlA1-positive platelets were treated by a combination of i.v.-immunoglobulin (400 mg/kg b.w.) and a transfusion of maternal PlA1-negative platelets. In one infant this regimen was successful; the other one had to be retreated by i.v. immunoglobulin application (400 mg/kg b.w.) over a period of five days.
Choudhury
A R
AR
Universitäts-Kinderklinik, Göttingen.
Friederichs
E
E
Speer
C P
CP
Schröter
W
W
D016824:Antigens, Human Platelet; D001792:Blood Platelets / Q000276:immunology; D001803:Blood Transfusion; D003131:Combined Modality Therapy; D004899:Erythroblastosis, Fetal / Q000628:therapy*; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007231:Infant, Newborn; D039661:Integrin beta3; D007519:Isoantigens / Q000276:immunology*; D008297:Male; D017713:Platelet Transfusion; D013921:Thrombocytopenia / Q000276:immunology / Q000628:therapy*
D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007519:Isoantigens
Neonatale Alloimmunthrombozytopenie--Einfluss einer Kombinationstherapie aus i.v.-Immunglobulingabe und Transfusion PlA1-negativer maternaler Thrombozyten.