[Immunocompetent cells in organs of local and systemic immunity in intact and sensitized guinea pigs upon specific intranasal immunotherapy].
The normal levels of some lymphocyte populations and subpopulations in the lungs and lymph nodes draining the respiratory tract have been determined. The influence of systemic delayed hypersensitivity (DH) to staphylococci and the multiple introduction of staphylococcal antigen into intact and sensitized guinea pigs on the distribution of lymphocyte subpopulations in the central, peripheral and respiratory lymphoid organs has been studied. Systemic DH has been found to affect the level of immunocytes in the thymus and peripheral lymphoid organs; the local introduction of the allergen and the intranasal immunotherapy of systemic DH produce both local (the lungs and their lymph nodes) and systemic effect.
Nugmanova
Zh S
ZhS
Nugmanova
D S
DS
Beklemishev
N D
ND
Andreeva
N A
NA
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000382:microbiology; D007114:Immunization; D008221:Lymphoid Tissue / Q000276:immunology; D013210:Staphylococcus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000942:Antigens, Bacterial
Immunokompetentnye kletki v organakh lokal'nykh i sistemnogo immuniteta u intaktnykh i sensibilizirovannykh morskikh svinok pri spetsificheskoĭ intranazal'noĭ immunoterapii.