title: Synthesis and in vitro activity of new semi-synthetic coumermycin analogs: chemical modification at the C-3 amide.
abstract: Several new semi-synthetic coumermycin analogs, which carry a polar substituent at the C-3 amide moiety have been prepared. In vitro antibacterial activity of these new analogs against Gram-positive organisms, particularly methicillin-resistant strains of Staphylococci species has been described.
authors: Antiinfective Chemistry Department, Bristol-Myers Company, Wallingford, CT 06492.
authors: Y
authors: Y
authors: Ueda
authors: J M
authors: JM
authors: Chuang
authors: L B
authors: LB
authors: Crast
authors: R A
authors: RA
authors: Partyka
mesh_terms: D049933:Aminocoumarins; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003374:Coumarins / Q000138:chemical synthesis / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D049933:Aminocoumarins; D000900:Anti-Bacterial Agents; D003374:Coumarins; C004628:coumermycin