[The development of cytotoxic T lymphocytes in HLA-D/DR identity].
The development of cytotoxic T-lymphocytes is controlled by genes of the HLA complex and occurs, in the majority of cases, when the responding and stimulating subjects differ both in HLA-A, -B and HLA-D/DR antigens. We examined a married couple for kidney transplantation and found that they differed in HLA-A, -B antigens and were identical in HLA-DR antigens. The negative results of the MLC test confirmed the serological findings. Nevertheless, cytotoxic T-lymphocytes developed despite HLA-D/DR identity. The presented case is one of the few published exceptions to the rule governing the development of cytotoxic T-lymphocytes.
Porubská
S
S
Buc
M
M
Bencová
M
M
Nyulassy
S
S
Stefanovic
J
J
D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis* / Q000276:immunology; D006648:Histocompatibility; D006801:Humans; D008297:Male; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D006684:HLA-DR Antigens
Vznik cytotoxických lymfocytov T pri identite HLA-D/DR.