title: Is epidural anaesthesia using bupivacaine safe in patients with atrio-ventricular conduction defects?
abstract: Bupivacaine is known to interact with the conductive system of the heart, also when used in epidural anaesthesia. Ten patients, undergoing bupivacaine epidural anaesthesia for lower limb or pelvic surgery, who presented a history of cardiac conduction disturbances, were studied. The ECG was continuously monitored and a right ventricular bipolar electrode was used to monitor the following parameters: heart rate, QRS duration, QT, Atria-His and His-Ventricle intervals. No significant change was noticed, even in patients with a high grade conduction defect. The mean plasma level of bupivacaine was 0.33 +/- 0.23 micrograms/ml. Based on this experience, it seems that lumbar epidural anaesthesia with bupivacaine can be safely used in patients with asymptomatic AV conduction abnormalities.
authors: Department of Anaesthesiology, Centre Hospitalier Régional et Universitaire, Nimes, France.
authors: J J
authors: JJ
authors: Eledjam
authors: J E
authors: JE
authors: de la Coussaye
authors: P
authors: P
authors: Colson
authors: E
authors: E
authors: Viel
authors: B
authors: B
authors: Bassoul
authors: J P
authors: JP
authors: Bertinchant
authors: F
authors: F
authors: D'Athis
mesh_terms: D000767:Anesthesia, Epidural / Q000009:adverse effects*; D002045:Bupivacaine / Q000009:adverse effects* / Q000494:pharmacology; D004562:Electrocardiography; D006327:Heart Block / Q000503:physiopathology; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D007866:Leg / Q000601:surgery; D008991:Monitoring, Physiologic; D010388:Pelvis / Q000601:surgery
chemical_list: D002045:Bupivacaine