title: Cardiac peroxisomal enzymes and starvation.
abstract: In mice subjected to 3-day periods of food deprivation an increase in plasma free fatty acids occurred together with a rise in the cardiac content of fatty acyl CoA-oxidase (+ 15.2%) and catalase (+ 136.2%) activities. Stimulation of hydrogen peroxide production by the heart was found after 30 hours of fasting and this phenomenon was almost completely eliminated by 6 hours of refeeding. These data suggest that high myocardial loads of free fatty acids involve the peroxisomal enzymes in the beta-oxidation process. The resulting increase in hydrogen peroxide production could be partly responsible for the myocardial injury caused by starvation.
authors: Istituto di Farmacologia e Sezione Autonoma di Oncologia Clinica, Palermo, Italy.
authors: M
authors: M
authors: Crescimanno
authors: M G
authors: MG
authors: Armata
authors: L
authors: L
authors: Rausa
authors: M C
authors: MC
authors: Gueli
authors: C
authors: C
authors: Nicotra
authors: N
authors: N
authors: D'Alessandro
mesh_terms: D042962:Acyl-CoA Oxidase; D000818:Animals; D002374:Catalase / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006861:Hydrogen Peroxide / Q000378:metabolism; D051379:Mice; D008830:Microbodies / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology* / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D013217:Starvation / Q000378:metabolism
chemical_list: D005230:Fatty Acids, Nonesterified; D006861:Hydrogen Peroxide; D010088:Oxidoreductases; D002374:Catalase; D042962:Acyl-CoA Oxidase