Antibodies to calcitonin-gene related peptide reduce inflammation induced by topical mustard oil but not that due to carrageenin in the rat.
The influence of prior immunization to calcitonin gene-related peptide (CGRP) was examined on responses in two models of inflammation plasma: protein extravasation following topical application of mustard oil to the hind paw, and changes in paw volume following subplantar injection of carrageenin. In rats with antibodies to CGRP, there was an approximately 50% decrease compared to the control animals in extravasation, measured by the Evans blue method after topical mustard oil. In contrast, there was no difference in the inflammatory response to carrageenin in control and immunized rats. The results indicate that CGRP, which is probably released from the peripheral endings of cutaneous primary afferents, plays a role in the inflammatory response to mustard oil, but not carrageenin.
Louis
S M
SM
MRC Secretory Control Group, Physiological Laboratory, University of Liverpool, U.K.
Johnstone
D
D
Russell
N J
NJ
Jamieson
A
A
Dockray
G J
GJ
D000287:Administration, Topical; D000818:Animals; D000906:Antibodies; D015740:Calcitonin Gene-Related Peptide / Q000276:immunology / Q000502:physiology*; D002351:Carrageenan / Q000494:pharmacology*; D007114:Immunization; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D009150:Mustard Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000906:Antibodies; D009150:Mustard Compounds; D002351:Carrageenan; D015740:Calcitonin Gene-Related Peptide