title: [Choreo-ballistic status treated by GABA].
abstract: A successful GABA replacement therapy for choreo-ballistic status in a 9-year-old girl, who had been previously treated medically or surgically without beneficial results, was reported. Involuntary movements completely ceased after intravenous administration of GABA (the maximal doses: 533 mg/kg/day) of 3 weeks' duration. Chorea and ballism are assumed to be caused by hypofunction of the GABA-neurons in the basal ganglia. Administration of GABA has been considered to be ineffective for these involuntary movements, since GABA has been believed not to cross the blood-brain barrier. The present case suggests that a large amount of intravenous administration of GABA gives a chance to treat involuntary movements caused by deficiency of GABA-neurons, although the essential mechanism of intracerebral penetration of GABA remains uncertain.
authors: M
authors: M
authors: Hashimoto
authors: A
authors: A
authors: Yokota
authors: S
authors: S
authors: Matsuoka
authors: F
authors: F
authors: Shima
mesh_terms: D002648:Child; D002819:Chorea / Q000188:drug therapy*; D005260:Female; D006801:Humans; D009069:Movement Disorders / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
chemical_list: D005680:gamma-Aminobutyric Acid