[Organ changes in rabbits and rats in phosphothioaliphatic acid poisoning. I. Effect of inhibition of cholinesterase and various marker lysosomal hydrolases on organ changes in rabbits and rats in phosphothioaliphatic acid poisoning].
In the blood of rabbits and rats poisoned with Intration, after 1, 3, 6 and 10 days of the experiment activities of AChE and ChE as well as those of beta-GR, AcP, AP and KT were checked. In addition, in the cardiac muscle, kidneys and liver, marker lysosomal hydrolases, i.e. beta-GR and AcP were determined. A long-standing reduction in the activities of AChE and ChE and increase in the activities in the concentrations of nonphysiologically great lysosomal hydrolases and AP were noted. A correlation between the inhibition of cholinesterase and organic lesions was found. Lysosomal enzymes share the responsibility for the necrotic process or rabbits' and rats' cardiac muscles. The use of oximes (PAM and Toxobidine) considerably contributed to reactivation of AChE and ChE and to normalization of the test marker enzymes.
Giermaziak
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D000818:Animals; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases / Q000378:metabolism*; D006867:Hydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007306:Insecticides / Q000506:poisoning*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D062025:Organophosphate Poisoning; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds / Q000506:poisoning*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; D006867:Hydrolases; D002802:Cholinesterases; C100178:thiometon
Zmiany narzadowe u królików i szczurów w przebiegu zatrucia zwiazkiem fosforotioalifatycznym. Cześć I. Wpływ inhibicji esteraz cholinowych oraz niektórych markerowych hydrolaz lizosomalnych na zmiany narzadowe u królików i szczurów w przebiegu zatrucia zwiazkiem fosforotioalifatycznym.