title: High chlorpromazine doses and liver function.
abstract: The aim of the present study was to evaluate the in vivo effect of high chlorpromazine (CPZ) doses on hepatocellular function. Thirty male Wistar rats weighing 200 to 250 g were divided into two groups: control (C, N = 17), injected ip with saline, and CPZ (N = 13), injected ip with high chlorpromazine doses (initial dose of 30 mg/kg body weight followed by daily doses of 10 mg/kg for 7 days). No significant differences in serum levels of alanine-aminotransferase, alkaline phosphatase and bilirubin or in mitochondrial function (activated and basal respiration and mitochondrial respiration control (activated/basal ratio) were detected between the two groups.
authors: Departmento de Cirurgia, Faculdade de Medicina de Ribeirão Pretro, Universidade de São Paulo, Brasil.
authors: O
authors: O
authors: Castro-e-Silva Júnior
authors: R
authors: R
authors: Ceneviva
authors: J E
authors: JE
authors: Roselino
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001663:Bilirubin / Q000097:blood; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014021:Tissue Preservation
chemical_list: D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin; D002746:Chlorpromazine