LL-E19020 alpha and beta, animal growth promoting antibiotics: taxonomy, fermentation and biological activity.
Antibacterial antibiotics LL-E19020 alpha and beta were isolated from the fermentation broth of an actinomycete strain. Based on cultural and physiological characteristics, culture LL-E19020 was identified as a new subspecies of Streptomyces lydicus. The LL-E19020 alpha and beta antibiotics were found to possess a very narrow antibacterial spectrum against human pathogens. In studies in chickens, LL-E19020 alpha demonstrated excellent growth promoting activity.
Maiese
W M
WM
Medical Research Division, American Cyanamid Company, Lederle Laboratory, Pearl River, New York 10965.
Lechevalier
M P
MP
Lechevalier
H A
HA
Korshalla
J
J
Goodman
J
J
Wildey
M J
MJ
Kuck
N
N
Conner
S D
SD
Greenstein
M
M
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002645:Chickens; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005285:Fermentation; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006133:Growth Substances / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D051379:Mice; D013291:Streptococcus / Q000187:drug effects; D013302:Streptomyces / Q000145:classification / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006133:Growth Substances; C058743:phenelfamycin F; C058741:phenelfamycin E