Effect of a moderate fish intake on haemostatic parameters in healthy males.
This article describes the results of a dietary intervention study performed in three different centers. In the study the effect of a diet enriched with fish on the coagulation tendency of blood was investigated. Two groups of 40 volunteers were given a dietary supplement consisting of 135 g of canned mackerel or meat paste (control) for a 6 weeks period. Compliance, monitored by measuring the urinary excretion of lithium, added to the supplements, was about 80%. Before, during and at the end of the experimental period a number of hemostatic parameters, reflecting the coagulation tendency of blood and the procoagulant activity of monocytes, were measured. The fish supplement did not cause a significant effect on the prothrombin time and on the levels of factor VII, activated factor VII, antithrombin III, von Willebrand factor, fibrinogen, plasminogen and alpha 2-antiplasmin. A slight but transient prolongation in the activated partial thromboplastin time was observed as well as a significant increase in the factor X level, which became more pronounced with prolongation of the experimental period; no activated factor X was found. A tendency towards a stimulation of monocyte procoagulant activity was noticed.
Muller
A D
AD
Department of Biochemistry, University of Limburg, Maastricht, The Netherlands.
van Houwelingen
A C
AC
van Dam-Mieras
M C
MC
Bas
B M
BM
Hornstra
G
G
D000328:Adult; D000818:Animals; D001779:Blood Coagulation Factors / Q000502:physiology; D001780:Blood Coagulation Tests; D005396:Fish Products; D006487:Hemostasis; D006801:Humans; D008297:Male; D008461:Meat Products; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D010473:Perciformes
D001779:Blood Coagulation Factors; C045071:leukocyte procoagulant activity