[Preparation and pharmacologic activity of amido- derivatives of 3-methyl-3,4-dihydro benzo- and pyrido-1,2,4-triazin-3-acetic acids].
Thirteen amidoderivatives of 3-methyl-3,4-dihydro-6-R-benzo-1,2,4-triazin-3-yl-acetic acids and of 3-methyl-3,4-dihydro-pyrido [3,2-e]/[3,4-e]-1,2,4-triazin- 3-yl-acetic acids were prepared and submitted to a wide pharmacological screening. The dihydrobenzotriazine and dihydropyridotriazine moieties were endowed with a wide pharmacogenic capacity; in fact, several compounds exhibited high antiinflammatory [(I c), (I d), (II d), (V f), (VI f)], diuretic [(I f), (I g), (I h)] and antihypertensive activities [(I d), (III d)], as well as minor effects on the C.N.S.
Boido
A
A
Istituto di Scienze Farmaceutiche, Università di Genova.
Novelli
F
F
Savelli
F
F
Sparatore
F
F
Russo
S
S
Filippelli
W
W
Susanna
V
V
Marmo
E
E
D000085:Acetates / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D000927:Anticonvulsants; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004231:Diuresis / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D000959:Antihypertensive Agents; D011725:Pyridines; D014227:Triazines
Preparazione e attività farmacologica di ammidoderivati 3-metil-3,4-diidro benzo e pirido-1,2,4-triazin-3-acetici.