[(Pyrimidin-5-yl)-2-propionic acids as potential anti-inflammatory agents and peripheral analgesics].
The (pyrimidin-5-yl)-2-propionic acids 3a-f have been synthetized starting from the corresponding 5-vinylpyrimidins 1a-f. They were tested for antiphlogistic and analgesic activity. Only three of these compounds showed a moderate antiinflammatory and analgesic activity.
Kvita
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Schweizer
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A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D011422:Propionates / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; D011743:Pyrimidines
(Pyrimidin-5-yl)-2-propionsäuren als potentielle Antiphlogistica und periphere Analgetica.