Induction of murine macrophage fungal killing by interleukin 3.
The effect of recombinant interleukin 3 (IL-3) on the function of murine resident peritoneal macrophages was investigated. IL-3 enhanced the phagocytosis of Candida pseudotropicalis and Candida albicans and enhanced killing of the former. The enhanced killing is inhibited by scavengers of oxygen radicals, suggesting that IL-3 primes macrophages for enhanced oxidative metabolism in response to Candida.
Bleiberg
I
I
Department of Histology and Cell Biology, Sackler School of Medicine, Tel-Aviv University, Ramat-Aviv, Israel.
Kletter
Y
Y
Riklis
I
I
Fabian
I
I
D000818:Animals; D002175:Candida; D007377:Interleukin-3 / Q000494:pharmacology*; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000494:pharmacology
D007377:Interleukin-3; D013482:Superoxide Dismutase