title: Inhibition of pregnancy in heifers, using a repositol formulation of melengestrol acetate.
abstract: Efficacy of a repositol formulation of melengestrol acetate (MGA) for inhibition of pregnancy was determined in one hundred 14- to 16-month-old beef heifers. Nonpregnant heifers were allocated on the basis of weight into 5 groups of 20 heifers each and were given 0, 30, 60, 90, or 120 mg of repositol MGA, SC, on day 0. Four bulls, determined to be satisfactory potential breeders, were pastured with the heifers from postinjection days (PID) 7 to 177. The day of gestation was estimated for each heifer by rectal palpation at PID 59, 91, 134, 177, and 225. Heifers not pregnant by PID 177 were assigned a day of conception of greater than 177. For heifers given 0, 30, 60, 90, and 120 mg of MGA, respectively, the percentage pregnant at PID 177 was 95, 95, 50, 15, and 15%, and the median day of estimated conception was PID 21, 87, 175, greater than 177, and greater than 177. Repositol MGA significantly (P less than 0.001) affected the distribution of conception times over all doses. Average daily gain (+/- SEM) for 178 days was 0.28 +/- 0.04 kg, 0.24 +/- 0.03 kg, 0.33 +/- 0.04 kg, 0.40 +/- 0.03 kg, and 0.35 +/- 0.03 kg for heifers given 0, 30, 60, 90, and 120 mg of MGA, respectively. Increased dose of repositol MGA was associated with increased average daily gain, but this effect was not apparent when days pregnant were taken into account. Repositol MGA was an effective contraceptive for pastured heifers and the duration of its effect was dose-dependent.
authors: Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801.
authors: J G
authors: JG
authors: Floyd
authors: R S
authors: RS
authors: Ott
authors: R M
authors: RM
authors: Weigel
authors: G M
authors: GM
authors: Zinn
authors: J E
authors: JE
authors: Hixon
mesh_terms: D000818:Animals; D002417:Cattle / Q000502:physiology*; D003267:Contraception / Q000662:veterinary*; D003271:Contraceptive Agents, Female / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007279:Injections, Subcutaneous; D008552:Melengestrol Acetate / Q000008:administration & dosage*; D011245:Pregnadienes / Q000008:administration & dosage*; D011247:Pregnancy; D013997:Time Factors; D015430:Weight Gain
chemical_list: D003271:Contraceptive Agents, Female; D011245:Pregnadienes; D008552:Melengestrol Acetate