Hypersensitivity reactions to deoxycoformycin.
Deoxycoformycin (dCF) is a promising new antineoplastic agent in the treatment of lymphoid malignancies, particularly hairy cell leukemia (HCL). Skin toxicity in the form of a maculopapular eruption has previously been reported but has not clearly been associated with idiosyncratic reactions. We present five cases of dCF-related hypersensitivity reactions in which additional systemic manifestations indicated an allergic etiology. The value of dCF in treating lymphoid neoplasms suggests that further study of the treatment of these reactions is indicated.
O'Dwyer
P J
PJ
Investigational Drug Branch, National Cancer Institute Bethesda, MD.
King
S A
SA
Eisenhauer
E
E
Grem
J L
JL
Hoth
D F
DF
D000328:Adult; D000368:Aged; D000493:Allopurinol / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003070:Coformycin / Q000009:adverse effects* / Q000031:analogs & derivatives; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015649:Pentostatin; D012263:Ribonucleosides / Q000009:adverse effects*; D012867:Skin / Q000187:drug effects
D000970:Antineoplastic Agents; D012263:Ribonucleosides; D003070:Coformycin; D015649:Pentostatin; D000493:Allopurinol