A new zinc-62/copper-62 generator as a copper-62 source for PET radiopharmaceuticals.
A new 62Zn/62Cu generator system was designed to provide a readily available 62Cu source for positron emission tomographic radiopharmaceuticals, based on the differences of complex formation between Zn and Cu. Noncarrier added 62Cu was selectively eluted as a glycine complex from 62Zn-adsorbed cation-exchange resin (CG-120, Amberlite), when a glycine solution (200 mM) was used as the eluant. The elution efficiency and radionuclidic purity of 62Cu were 70% and greater than 99.9%, respectively. Copper in glycine solution showed rapid complex formation with dithiosemicarbazone, which is one of the established Cu-binding agents for bifunctional chelating radiopharmaceutical.
Fujibayashi
Y
Y
Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Matsumoto
K
K
Yonekura
Y
Y
Konishi
J
J
Yokoyama
A
A
D002851:Chromatography, High Pressure Liquid; D003301:Copper Radioisotopes; D005998:Glycine; D011876:Radionuclide Generators; D012996:Solutions; D013882:Thiosemicarbazones; D014055:Tomography, Emission-Computed; D015037:Zinc Radioisotopes
D003301:Copper Radioisotopes; D012996:Solutions; D013882:Thiosemicarbazones; D015037:Zinc Radioisotopes; C015848:dithiosemicarbazone; D005998:Glycine