Use of nude mice in experimental neutron capture therapy with 10B-BPA.
Mouse B16 melanoma allografts in nude mice were successfully treated by thermal neutron irradiation after IP injection of 10B-paraboronophenylalanine hydrochloride. The tumor growth was significantly suppressed for 4 weeks after irradiation, compared with animals given neutron irradiation alone. Tumor-bearing nude mice were shown to be useful for evaluating the treatment for melanoma.
Tamaoki
N
N
Department of Pathology, School of Medicine, Tokai University, Kanagawa-ken, Japan.
Ueda
M
M
Tamauchi
S
S
Yamamoto
K
K
Mishima
Y
Y
D000818:Animals; D001896:Boron Compounds / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D008546:Melanoma, Experimental / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D051379:Mice; D008819:Mice, Nude; D009502:Neutrons; D010649:Phenylalanine / Q000378:metabolism / Q000494:pharmacology / Q000031:analogs & derivatives; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D014184:Transplantation, Homologous
D001896:Boron Compounds; D010649:Phenylalanine; C033685:4-boronophenylalanine