Studies on the mechanism of benzene toxicity.
Using the 59Fe uptake method of Lee et al. it was shown that erythropoiesis in female mice was inhibited following IP administration of benzene, hydroquinone, p-benzoquinone, and muconaldehyde. Toluene protected against the effects of benzene. Coadministration of phenol plus either hydroquinone or catechol resulted in greatly increased toxicity. The combination of metabolites most effective in reducing iron uptake was hydroquinone plus muconaldehyde. We have also shown that treating animals with benzene leads to the formation of adducts of bone marrow DNA as measured by the 32P-postlabeling technique.
Snyder
R
R
Joint Graduate Program in Toxicology, Rutgers, State University of New Jersey, Piscataway.
Dimitriadis
E
E
Guy
R
R
Hu
P
P
Cooper
K
K
Bauer
H
H
Witz
G
G
Goldstein
B D
BD
D000447:Aldehydes / Q000633:toxicity; D000818:Animals; D001554:Benzene / Q000633:toxicity*; D016227:Benzoquinones; D001853:Bone Marrow / Q000187:drug effects*; D002396:Catechols / Q000494:pharmacology; D004247:DNA / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D006873:Hydroquinones / Q000633:toxicity; D007504:Iron Radioisotopes; D051379:Mice; D019800:Phenol; D010636:Phenols / Q000494:pharmacology; D011809:Quinones / Q000633:toxicity; D051381:Rats; D014050:Toluene / Q000494:pharmacology
D000447:Aldehydes; D016227:Benzoquinones; D002396:Catechols; D006873:Hydroquinones; D007504:Iron Radioisotopes; D010636:Phenols; D011809:Quinones; C034476:muconaldehyde; D019800:Phenol; D014050:Toluene; C004532:quinone; D004247:DNA; D001554:Benzene; C034221:catechol; C031927:hydroquinone