title: Effects of neuropeptide Y and calcitonin gene-related peptide on local cerebral blood flow in rat striatum.
abstract: The effects of neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) on local cerebral blood flow (LCBF) were studied in vivo in rat striatum. Administration of 1 and 5 nmol NPY as a bolus into the internal carotid artery caused a dose-dependent decrease in the ipsilateral striatal LCBF. This decrease developed slowly and persisted for at least 2 h, without affecting mean blood pressure. In contrast, CGRP, at a concentration of 10 pmol, increased striatal LCBF by about 30%, and the duration of the increase was about 1 h. However, at higher doses of CGRP no increase in LCBF was observed. These results suggest that NPY and CGRP released from nerve fibers innervating blood vessels can function as long-acting modulators of CBF.
authors: Department of Neurosurgery, Nagoya University School of Medicine, Japan.
authors: Y
authors: Y
authors: Suzuki
authors: S
authors: S
authors: Satoh
authors: I
authors: I
authors: Ikegaki
authors: T
authors: T
authors: Okada
authors: M
authors: M
authors: Shibuya
authors: K
authors: K
authors: Sugita
authors: T
authors: T
authors: Asano
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide; D003342:Corpus Striatum / Q000098:blood supply* / Q000187:drug effects; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology*; D009479:Neuropeptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009478:Neuropeptide Y; D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide