Acute effects of peripheral histamine administration on arginine-8-vasopressin and oxytocin levels in rat spinal cord.
The effects of a single injection of 20 mg/kg histamine on the immunoreactive arginine-8-vasopressin (AVP) and oxytocin (OXT) levels in the rat spinal cord were studied after peripheral (intraperitoneal) administration. Histamine induced a 60% elevation in the AVP content of the spinal cord, whereas the spinal level of OXT decreased by 36%. The findings suggest that peripheral histamine differentially affects the AVP and OXT levels in the spinal cord.
Jójárt
I
I
First Department of Medicine, Albert Szent-Györgyi University Medical School, Szeged, Hungary.
Vecsernyés
M
M
Jójárt
J
J
Laczi
F
F
Szabó
G
G
Kovács
G L
GL
Janáky
T
T
László
F A
FA
Telegdy
G
G
D000818:Animals; D006632:Histamine / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D010121:Oxytocin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects* / Q000378:metabolism; D014668:Vasotocin / Q000378:metabolism*
D010121:Oxytocin; D006632:Histamine; D014668:Vasotocin