Altered levels of calcitonin gene-related peptide (CGRP)-like immunoreactivity of cat lumbar motoneurons after chronic spinal cord transection.
In cats subjected to total spinal cord transection at the lower thoracic level, the calcitonin gene-related peptide (CGRP)-like immunoreactivity (LI) was studied in motoneuron cell bodies in the L6-L7 segments. In transected animals, the CGRP-immunoreactive labeling of the motoneurons was virtually absent. When combining the spinal cord transection with a unilateral rhizotomy of all dorsal roots below the transection, however, an apparently normal labelling pattern of CGRP-LI of the motoneurons was displayed on both sides. Thus, surgical interventions which affect afferent pathways to the motoneurons may have influence on the levels of CGRP-LI in otherwise intact motoneurons.
Arvidsson
U
U
Department of Anatomy, Karolinska Institutet, Stockholm, Sweden.
Cullheim
S
S
Ulfhake
B
B
Hökfelt
T
T
Terenius
L
L
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D002415:Cats; D007150:Immunohistochemistry; D009046:Motor Neurons / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism* / Q000601:surgery
D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide