Treatment- and task-induced changes in interhemispheric EEG.
Fifteen male alcoholics treated for three weeks with phenobarbital, diazepam or placebo, the treatment being shifted in the fourth week to placebo in the medicament groups and to phenobarbital in the placebo one, were examined once a week. Frequency analyzed EEG recordings from both hemispheres at three activation levels (relaxation, vigilance, stress) were evaluated and left/right log power ratios formed to ascertain possible hemispheric preponderance, a total of 201600 ratios being evaluated. Blood levels, performance and self estimated mood modalities were obtained. Significant effects (1) of different types of treatment, (2) of a shift in type of treatment and (3) of shifts in activation level on frequency dependent hemispheric preponderance were ascertained and a relation to changes in clinical course of mood modalities was established.
Schwarz-Ottersbach
E
E
Psychiatric University Clinic, Basel, Switzerland.
Goldberg
L
L
D000437:Alcoholism / Q000188:drug therapy / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D003975:Diazepam / Q000627:therapeutic use*; D004569:Electroencephalography; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use*
D003975:Diazepam; D010634:Phenobarbital