[Suppression by bone marrow cells of the level of specific IgE antibodies in the blood of mice and decrease in the production of IGE by bone marrow cells].
Changes in the level of the specific IgE-antibodies to ovalbumin under the influence of syngeneic cells of a bone marrow were studied. The IgE-response was induced by ovalbumin in mice (CBA X C57Bl/6)F1. The bone marrow cells suspensions (20-30 X 10(6) cells per mouse) from syngeneic donors was inoculated simultaneously with the immunization. It was found that bone marrow cells suppressed both the level of IgE-antibodies in experimental mice serum and the production of IgE by the bone marrow cells of the recipient. The ability to suppress IgE-response remained when erythrocytes, monocytes and T-lymphocytes were removed from inoculated suspensions. The bone marrow cells taken from the mice immunized with ovalbumin, at the stage of a decreasing IgE-response, provided more pronounced suppression, than bone marrow cells taken from intact animals.
Siusiukin
M Iu
MIu
Vlasov
A A
AA
Pol'ner
A A
AA
D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D001853:Bone Marrow / Q000276:immunology*; D016026:Bone Marrow Transplantation; D007108:Immune Tolerance; D007114:Immunization; D007073:Immunoglobulin E / Q000032:analysis*; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D014185:Transplantation, Isogeneic
D007073:Immunoglobulin E; D010047:Ovalbumin
Podavlenie kletkami kostnogo mozga urovnia spetsificheskikh IgE-antitel v syvorotke krovi mysheĭ i snizhenie vyrabotki IgE kostnomozgovymi kletkami.