[The electrophysiologic effect of atenolol and nitrendipine on normal and ischemic rabbit myocardium in situ. III. Effects on ventricular fibrillation threshold].
This study was designed to assess myocardial vulnerability by measuring ventricular pacing threshold (VPT), multiple extrasystoles threshold (MET), ventricular tachycardia threshold (VTT) and ventricular fibrillation threshold (VFT) by means of the pulse train stimulating method. The results showed that: (1) VFT is a quantitative index of myocardial vulnerability: (2) MET, positively correlated with VFT, might become a substitute for VFT as an index of vulnerability to ventricular fibrillation: (3) atenolol, both in normal and ischemic myocardium, is able to make a significant elevation of VFT, which is considered as an antifibrillation effect: (4) nitrendipine exerted no apparent effects on all the parameters.
Ren
X L
XL
Lin
C X
CX
D000818:Animals; D001262:Atenolol / Q000494:pharmacology / Q000627:therapeutic use*; D004558:Electric Stimulation; D004594:Electrophysiology; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D009568:Nitrendipine / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D014693:Ventricular Fibrillation / Q000209:etiology / Q000517:prevention & control*
D001262:Atenolol; D009568:Nitrendipine