[Pharmacokinetic evaluations and analysis of aztreonam in children].
Aztreonam (AZT), monocyclic beta-lactam antimicrobial agent, was administered to 9 children at a dose level of 30 mg/kg through intravenous drip infusion for half-hour. Using serum levels of the drug obtained in blood samples, pharmacokinetic parameters were calculated and a simulation curve of serum levels was drawn automatically using a micro-computer. The mean values (n = 9) for elimination constant (Kel) and half-life (T 1/2) were 0.67 hr-1 and 1.08 hours, respectively. The mean apparent volume of distribution was 4.29 L, and serum clearance was 0.17 L/kg/hr. A basic analysis for the efficacy dose of AZT was performed using above mentioned parameters.
Kawasaki
H
H
Department of Pediatrics, Touhoku Rohsai Hospital.
D000293:Adolescent; D000367:Age Factors; D001398:Aztreonam / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male
D001398:Aztreonam