title: Effect of incorporation of serum from dogs with renal impairment on canine erythroid bone marrow cultures.
abstract: Serum from dogs with surgically induced renal impairment was incorporated into the medium for erythroid bone marrow cultures. A significant correlation was found between serum activities of erythropoietin and numbers of erythroid colony-forming units grown in culture. Serum creatinine concentrations had no correlation, and serum parathyroid hormone activities had a negative correlation with numbers of erythroid colony-forming units that was below the level of significance. Purified 1-84 parathyroid hormone added to bone marrow cultures was found to be stimulatory to erythroid colony-forming unit growth in higher concentrations, but decreased the number of burst-forming units. Unmeasured substances in the canine serum appeared to have a greater effect on the canine erythroid bone marrow cultures than did creatinine or parathyroid hormone values.
authors: Department of Veterinary Pathology, College of Veterinary Medicine, Texas A&M University, College Station 77843.
authors: M B
authors: MB
authors: Petrites-Murphy
authors: K R
authors: KR
authors: Pierce
authors: J W
authors: JW
authors: Fisher
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D003404:Creatinine / Q000097:blood; D003470:Culture Media; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D015672:Erythroid Precursor Cells / Q000166:cytology*; D004921:Erythropoietin / Q000097:blood; D007674:Kidney Diseases / Q000097:blood / Q000662:veterinary*; D010281:Parathyroid Hormone / Q000097:blood / Q000494:pharmacology
chemical_list: D003470:Culture Media; D010281:Parathyroid Hormone; D004921:Erythropoietin; D003404:Creatinine