The pharmacokinetics of meropenem in volunteers.
Two human volunteer studies were performed with meropenem: a dose proportionality study of 0.25, 0.5 and 1.0 g and a probenecid interaction study. Six volunteers took part in each study. Meropenem was generally well tolerated: One volunteer was withdrawn from the dose proportionality study because of looseness of stool and abdominal pain after a dose of 1.0 g. The plasma concentrations of meropenem were linearly related to dose. The half-life of meropenem was approximately 1 h and the urinary recovery of unchanged drug was 79%. In the presence of probenecid the plasma half-life of meropenem was increased by 33% but the urinary recovery was unaffected.
Bax
R P
RP
ICI Pharmaceuticals, Macclesfield, Cheshire, UK.
Bastain
W
W
Featherstone
A
A
Wilkinson
D M
DM
Hutchison
M
M
Haworth
S J
SJ
D000328:Adult; D015780:Carbapenems / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male; D000077731:Meropenem; D011339:Probenecid / Q000494:pharmacology; D012016:Reference Values; D013845:Thienamycins / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D015780:Carbapenems; D013845:Thienamycins; D000077731:Meropenem; D011339:Probenecid