title: Interleukin 1 and tumor necrosis factor: studies on the induction by lipopolysaccharide partial structures.
abstract: Minimal concentration ranges of lipopolysaccharides, natural and synthetic lipid As, and partial structures were established for the induction of release of IL-1 and TNF from human MNC. LPS was more potent than lipid A. Partial structures of lipid A lacking nonhydroxylated fatty acids were inactive, but in combination with LPS or lipid A exhibited time-dependent synergistic or antagonistic effects.
authors: Forschungsinstitut Borstel, FRG.
authors: H D
authors: HD
authors: Flad
authors: H
authors: H
authors: Loppnow
authors: W
authors: W
authors: Feist
authors: M H
authors: MH
authors: Wang
authors: H
authors: H
authors: Brade
authors: S
authors: S
authors: Kusumoto
authors: E T
authors: ET
authors: Rietschel
authors: A J
authors: AJ
authors: Ulmer
mesh_terms: D006017:Glycolipids / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008050:Lipid A / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D006017:Glycolipids; D007375:Interleukin-1; D008050:Lipid A; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; C044283:lipid X