Proteoglycans in the pathogenesis of amyloidosis.
Glycosaminoglycans, which occur in most organisms from bacteria to vertebrates, appear to be present in all amyloid deposits regardless of the protein involved. This, their early appearance, and their likely interaction with specific proteins imply that they play an essential role in the pathogenesis of amyloidosis.
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Veterans Administration Medical Center, Salt Lake City, UT 84148.
D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology*; D000686:Amyloidosis / Q000378:metabolism / Q000503:physiopathology; D006025:Glycosaminoglycans / Q000378:metabolism / Q000502:physiology; D006801:Humans; D011509:Proteoglycans / Q000378:metabolism / Q000502:physiology*
D006025:Glycosaminoglycans; D011509:Proteoglycans