[The search for antibiotics not exerting activating action in the persistence of the tick-borne encephalitis virus].
Chronic tick-borne encephalitis (TBE) frequently develops in the presence of concomitant diseases requiring antibiotic therapy. Because some antibiotics, e.g. streptomycin, strongly activate persisting TBE virus, a study was carried out in search of antibiotics without the activating effect. The experiments were carried out in Syrian hamsters inoculated subcutaneously with the Vasil'chenko strain of TBE virus which at 60-348 days of the persistent infection were given florimycin, levomycetin and kanamycin. The antibiotics were administered for 3 weeks. Levomycetin showed no activating properties, while kanamycin and florimycin exerted weak activating effect on the persisting TBE virus (isolated from 5% of the specimens) without marked immunosuppressive effect or manifestation of the infection. The TBE virus strains isolated on the 205th day from the brain and 348th day from the spleen of the hamsters given kanamycin and florimycin had higher virulence than the original strain.
Malenko
G V
GV
Pogodina
V V
VV
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D000998:Antiviral Agents; D001921:Brain / Q000382:microbiology; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D004669:Encephalitis Viruses, Tick-Borne / Q000187:drug effects* / Q000254:growth & development / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy / Q000382:microbiology; D006389:Hemagglutinins, Viral / Q000276:immunology; D008647:Mesocricetus; D013997:Time Factors; D014775:Virus Activation / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000888:Antibodies, Anti-Idiotypic; D000998:Antiviral Agents; D006389:Hemagglutinins, Viral
Poisk antibiotikov, ne okazyvaiushchikh aktiviruiushchego deĭstviia pri persistentsii virusa kleshchevogo éntsefalita.