Amplification of uteroglobin secretion by alternating prolactin-progesterone administration.
Long-term ovariectomized rabbits were given injections of progesterone and prolactin in an alternating sequence (progesterone for 5 days, prolactin for 4 days and progesterone for 5 days) to test the hypothesis that each of these hormones acts to increase the other's receptor, resulting in a positive feedback process whereby prolactin augments the progesterone-dependent increase in the mRNA for the uterine protein, uteroglobin. The results of this study support the hypothesis, in that the experimental rabbits produced exceptionally large concentrations of uteroglobin.
Daniel
J C
JC
Department of Biological Sciences, Old Dominion University, Norfolk, Virginia 23529-0163.
Juneja
S C
SC
D000818:Animals; D004357:Drug Synergism; D005260:Female; D006023:Glycoproteins / Q000096:biosynthesis*; D010052:Ovariectomy; D011374:Progesterone / Q000494:pharmacology*; D011388:Prolactin / Q000494:pharmacology*; D011817:Rabbits; D014598:Uteroglobin / Q000096:biosynthesis*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism
D006023:Glycoproteins; D011374:Progesterone; D011388:Prolactin; D014598:Uteroglobin