[Effect of various levels of alcohol consumption on plasma lipoproteins and apoproteins].
To assess the abnormalities induced by alcohol on plasma lipids and lipoproteins and their possibly involved mechanisms three basis of the daily intake: social drinkers (less than or equal to 20 g/day; n = 10), moderate drinkers (greater than 20 to less than 70 g/day; n = 11), and severe drinkers (greater than or equal to 70 g/day; n = 15). Eleven nondrinkers were evaluated as control group. Very low density lipoproteins (VLDL), low density lipoproteins (LDL), high density lipoproteins (HDL)-2 and HDL-3 were isolated by preparative sequential isopicnic centrifugation, and their apolipoprotein and lipidic composition were measured. In the group of severe drinkers, a marked tendency of HDL-3 cholesterol to be higher than in the remaining groups was found. There was no correlation between this parameter and hepatic enzymes. The HDL-2 cholesterol of severe drinkers was significantly increased (p less than 0.005). The parallel enrichment in apolipoproteins C of the HDL-2 particle in all groups of alcohol users suggests a transfer phenomenon from VLDL. The apoA/C ratio of HDL-2 might be useful as a marker of alcohol intake.
Andrade Bellido
R J
RJ
Escolar Castellón
J L
JL
Aguado Guerrero
F
F
Valdivielso Felices
P
P
González Santos
P
P
D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking; D000437:Alcoholism / Q000097:blood; D001059:Apoproteins / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D006801:Humans; D008074:Lipoproteins / Q000097:blood* / Q000145:classification; D008297:Male; D008875:Middle Aged; D013695:Temperance
D001059:Apoproteins; D008076:Cholesterol, HDL; D008074:Lipoproteins
Influencia de diversos grados de consumo de alcohol sobre las lipoproteínas y apolipoproteínas plasmáticas.