title: Human immunodeficiency virus and human T-cell leukemia virus type I in patients undergoing maintenance hemodialysis in Miami.
abstract: The high prevalence of human immunodeficiency virus (HIV-1) infection in populations at risk in Miami prompted a seroepidemiologic study of both HIV-1 and the human T-cell leukemia virus type I (HTLV-I), a closely related virus, in our patients receiving chronic hemodialysis. One hundred twenty-nine patients undergoing hemodialysis in 1986 and 1987 were tested for antibody against both viral antigens by EIA (Abbott Laboratories, Abbott Park, IL). Seroreactive samples for HIV-1 and/or HTLV-I were confirmed by Western blot and, for HTLV-I, by viral cultures. Thirty patients (23.2%) were positive for retroviral infection (22 for HIV-1 alone, four for HTLV-I alone, and four for both HIV-1 and HTLV-I). The most important risk factor was intravenous drug use, followed by blood transfusion. Patients with HIV-1 had lower T4-T8 ratios and higher mortality than those with HTLV-I infection alone. It was concluded that HTLV-I, as well as HIV-1, infection is endemic in chronic dialysis centers in Miami. The clinical consequences of HTLV-I infection in relatively immunocompromised patients with chronic uremia who are undergoing chronic hemodialysis remains to be established.
authors: Department of Medicine, University of Miami School of Medicine, FL 33101.
authors: G
authors: G
authors: Perez
authors: C
authors: C
authors: Ortiz-Interian
authors: H
authors: H
authors: Lee
authors: M
authors: M
authors: de Medina
authors: M
authors: M
authors: Cerney
authors: J P
authors: JP
authors: Allain
authors: E
authors: E
authors: Schiff
authors: E
authors: E
authors: Parks
authors: W
authors: W
authors: Parks
authors: J J
authors: JJ
authors: Bourgoignie
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D005431:Florida; D015483:HIV Antibodies / Q000032:analysis; D006679:HIV Seropositivity / Q000453:epidemiology; D015497:HIV-1; D015481:HTLV-I Antibodies / Q000032:analysis; D015490:HTLV-I Infections / Q000150:complications / Q000453:epidemiology*; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D007275:Injections, Intravenous; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D006435:Renal Dialysis; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000150:complications; D065227:Transfusion Reaction; D014195:Travel
chemical_list: D015483:HIV Antibodies; D015481:HTLV-I Antibodies