Interleukin-1 potentiates the development of collagen-induced arthritis in mice.
1. The subcutaneous administration of recombinant human interleukin-1 beta (rhIL-1 beta) was found to induce an increased incidence and earlier onset of collagen-induced arthritis in mice. 2. The rhIL-1 beta had different effects, depending on when it was administered after collagen-immunization. 3. The effect of rhIL-1 beta may be due, in part, to augmentation of the immune response to type II collagen. 4. Interleukin-1-accelerated, collagen-induced arthritis will provide a useful model for investigating the role of interleukin-1 in the regulation of arthritic diseases, and the development of anti-arthritic therapeutics.
Killar
L M
LM
Hypersensitivity Diseases Research, Upjohn Company, Kalamazoo, Michigan 49001.
Dunn
C J
CJ
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000276:immunology*; D003094:Collagen / Q000276:immunology; D004195:Disease Models, Animal; D007109:Immunity; D007375:Interleukin-1 / Q000276:immunology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D011994:Recombinant Proteins / Q000276:immunology
D007375:Interleukin-1; D011994:Recombinant Proteins; D003094:Collagen