The C57BL/6 nude, beige mouse: a model of combined T cell and NK effector cell immunodeficiency.
This article describes the construction and establishment of a double congenic nude, beige C57BL/6 (B6 nu, bg) mouse strain. The mice do not show higher fragility than C57BL/6 nude mice and the double congenic strain can be maintained under conventional mouse housing conditions. Although the B6 nu, bg display a very low natural killer activity which cannot be enhanced by an interferon inducer (poly(I-C], they lack responsiveness to a T cell mitogen (concanavalin A); and they also show extremely low responsiveness to a B cell mitogen (0128: B12 Escherichia coli lipopolysaccharide) probably as a result of combined effects of the beige and nude genes in the C57BL/6 genetic context.
Pflumio
F
F
Laboratory of Immunology, Louis Pasteur University Strasbourg 1, Illkirch, France.
Fonteneau
P
P
Gavériaux
C
C
Cammisuli
S
S
Loor
F
F
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003208:Concanavalin A / Q000494:pharmacology; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics / Q000276:immunology*; D008819:Mice, Nude / Q000235:genetics / Q000276:immunology*; D010375:Pedigree; D011070:Poly I-C / Q000494:pharmacology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D008070:Lipopolysaccharides; D003208:Concanavalin A; D011070:Poly I-C