Susceptibilities to ceftriaxone of streptococcal strains associated with infective endocarditis.
We determined the bactericidal activity of ceftriaxone on 20 streptococci isolated from patients with infective endocarditis and that of penicillin G on 5 strains. The MICs of ceftriaxone were less than or equal to 2 micrograms/ml and the MBCs were low for 5 nontolerant strains (less than or equal to 2 micrograms/ml) and high for 15 tolerant strains (greater than or equal to 16 micrograms/ml). The maximal reduction of the viable bacterial counts after 24 h of exposure to antibiotic was achieved for a concentration of ceftriaxone of 4, 32 and 256 micrograms/ml, respectively for 5, 10 and 19 strains. The activity of penicillin G was similar.
Etienne
J
J
Hôpital Cardiologique, Laboratoire de Bactériologie, Lyon, France.
Vandenesch
F
F
Fauvel
J P
JP
Coulet
M
M
Brun
Y
Y
Fleurette
J
J
D002443:Ceftriaxone / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004697:Endocarditis, Bacterial / Q000382:microbiology*; D006801:Humans; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology; D013290:Streptococcal Infections / Q000382:microbiology*; D013291:Streptococcus / Q000187:drug effects* / Q000302:isolation & purification
D002443:Ceftriaxone; D010400:Penicillin G