Lymphokine production in patients with Alzheimer's disease.
The capacity of peripheral blood mononuclear cells (PBMC) isolated from patients with Alzheimer's disease to produce interleukin-1 and -2 (IL-1, IL-2) was compared to that of cells from age-matched controls and young healthy subjects. There was no difference in the production of both interleukins between patients and their age-matched controls. On the other hand, the production of IL-1 by the PBMC of healthy young volunteers was significantly higher than that of the cells from patients and subjects of the other two groups. Although the results indicated a higher production of IL-2 by PBMC from younger individuals, the difference in comparison with the other two groups was not statistically significant.
Bessler
H
H
Research Laboratory, Hasharon Hospital, Petah-Tiqva, Israel.
Sirota
P
P
Hart
J
J
Djaldetti
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008875:Middle Aged
D007375:Interleukin-1; D007376:Interleukin-2