Modification by apomorphine of the circling behaviour in the rat due to unilateral intranigral injection of 1-methyl-4-phenylpyridine (MPP+).
Unilateral injection of MPP+ (4 micrograms/1 microliter) into the pars compacta of the substantia nigra in rats induced ipsiversive circling immediately after the injection. Ipsiversive circling was still present 7 days after the injection. Systemic injection of the dopamine agonist apomorphine induced contraversive circling. These results show that MPP+ exerts a powerful neurotoxic action on the nigrostriatal dopaminergic system of the rat. Furthermore, the results suggest that unilateral intranigral administration of MPP+ in the rat may induce supersensitive dopamine receptors in the ipsilateral denervated striatum.
Lange
K W
KW
D015655:1-Methyl-4-phenylpyridinium; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011726:Pyridinium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology; D013378:Substantia Nigra / Q000187:drug effects* / Q000502:physiology
D011726:Pyridinium Compounds; D011954:Receptors, Dopamine; D001058:Apomorphine; D015655:1-Methyl-4-phenylpyridinium