Is intact PTH a sensitive biochemical indicator of deranged calcium homeostasis in vitamin D deficiency?
Intact PTH was elevated in 38/40 Asians with reduced serum 25 hydroxyvitamin D [25(OH)D] including seven patients with normal serum calcium, phosphate and alkaline phosphatase. Changes in intact PTH were disproportionately greater than for other biochemical parameters, making it the most sensitive early indicator of deranged calcium homeostasis in vitamin D deficiency.
Ashby
J P
JP
Department of Clinical Chemistry, Northwick Park Hospital, Harrow, Middlesex, UK.
Newman
D J
DJ
Rinsler
M G
MG
D001206:Ascorbic Acid Deficiency / Q000097:blood* / Q000150:complications; D002118:Calcium / Q000097:blood*; D015331:Cohort Studies; D006706:Homeostasis; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D010281:Parathyroid Hormone / Q000097:blood*; D012189:Retrospective Studies
D010281:Parathyroid Hormone; D002118:Calcium