Anti-inflammation induced by counter-irritation or by treatment with non-steroidal agents inhibits the growth of a tumour of non-detected immunogenicity.
Counter-irritation (CI) triggered by different non-specific irritant stimuli delayed the growth of a murine tumour of non-detected immunogenicity. The syngeneic LB tumour transplant by itself also induced CI and decreased the number of leukocytes migrating to a secondary s.c. irritant stimulus, e.g. sponge or carrageenan. On the other hand, partial inhibition of cell migration by treatment with either 0.5 mg kg-1 indomethacin or 0.3 mg kg-1 piroxicam retarded LB tumour growth, presumably by a mechanism unrelated to inhibition of immune responses by PGE2. It is suggested that CI may play a role in the early stages of concomitant resistance.
Sordelli
D O
DO
Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
Fontán
P A
PA
Meiss
R P
RP
Ruggiero
R A
RA
Bustuoabad
O D
OD
D000818:Animals; D005260:Female; D007213:Indomethacin / Q000627:therapeutic use*; D007509:Irritants; D015458:Leukemia, T-Cell / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010894:Piroxicam / Q000627:therapeutic use*
D007509:Irritants; D010894:Piroxicam; D007213:Indomethacin