title: Increased proto-oncogene expression in peripheral blood T lymphocytes from patients with systemic sclerosis.
abstract: The expression of c-myc, c-myb, and c-ras proto-oncogenes, determined using RNA hybridization techniques (slot-blot), was significantly increased in peripheral blood T lymphocytes, but not in B cells, from 17 patients with systemic sclerosis with diffuse scleroderma, compared with the expression in normal control subjects. The magnitude of expression of c-myc and c-myb tended to be higher in patients with early, active disease. These results demonstrate an in vivo activation of T cells from systemic sclerosis patients, which may play an important role in the pathogenesis of the disease.
authors: INSERM U-283, Hôpital Cochin, Paris, France.
authors: A
authors: A
authors: Kahan
authors: J
authors: J
authors: Gerfaux
authors: A
authors: A
authors: Kahan
authors: A M
authors: AM
authors: Joret
authors: C J
authors: CJ
authors: Menkès
authors: B
authors: B
authors: Amor
mesh_terms: D000199:Actins / Q000032:analysis; D000328:Adult; D001402:B-Lymphocytes; D015152:Blotting, Northern; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D012595:Scleroderma, Systemic / Q000097:blood* / Q000235:genetics; D013601:T-Lymphocytes
chemical_list: D000199:Actins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas