Allergy to nickel or cobalt: tolerance to nickel and cobalt samples in man and in the guinea pig allergic or sensitized to these metals.
The aim of this study was to evaluate, in animals and humans sensitive to nickel or cobalt, the tolerance to manufactured metal samples of nickel and cobalt of a defined metallographic structure, plated or not with a layer of chrome or copper/chrome of a determined thickness. Under the defined experimental conditions, a guinea pig sensitized to one metal (nickel or cobalt) was intolerant to both metals (nickel and cobalt). A plating of chrome or copper/chrome did not act as a protection. In the human, it was not the same: the tolerance to metal samples was determined by the specific sensitivity. A plating of chrome or copper/chrome did not act as protection.
Cavelier
C
C
Institut National de Recherche et de Sécurité, Vandoeuvre, France.
Foussereau
J
J
Gille
P
P
Zissu
D
D
D000818:Animals; D002857:Chromium / Q000009:adverse effects; D003035:Cobalt / Q000009:adverse effects* / Q000276:immunology; D003300:Copper / Q000009:adverse effects; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007114:Immunization; D009532:Nickel / Q000009:adverse effects* / Q000276:immunology; D010328:Patch Tests
D002857:Chromium; D003035:Cobalt; C029938:nickel sulfate; D003300:Copper; D009532:Nickel; C018021:cobaltous chloride