title: Isolation of the complementary DNA for human transcobalamin II.
abstract: A complementary DNA (cDNA) clone coding for transcobalamin II (TCII) has been isolated from a human umbilical vein endothelial cell cDNA library. The cDNA is 1.9 Kb and includes the nucleotide sequence which encodes the NH2-terminal 19 amino acids of human TCII. The size of the cDNA is sufficient to code for the entire protein and also contains the nucleotide sequence coding for a 24 amino acid leader peptide and a long untranslated 3' region. The availability of this cDNA will provide the opportunity to characterize genetic disorders of TCII.
authors: Department of Medicine, SUNY-Health Science Center, Brooklyn.
authors: O
authors: O
authors: Platica
authors: R
authors: R
authors: Geneczko
authors: A
authors: A
authors: Regec
authors: E V
authors: EV
authors: Quadros
authors: S P
authors: SP
authors: Rothenberg
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000302:isolation & purification*; D004730:Endothelium, Vascular / Q000032:analysis; D006801:Humans; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D014155:Transcobalamins / Q000235:genetics*; D014471:Umbilical Veins / Q000032:analysis
chemical_list: D014155:Transcobalamins; D004247:DNA