Transport of salicylamide from intestinal lumen to serosal compartment.
This study was aimed to clarify the fate of the perfused drug and the characteristics of the serosal compartment. A portion of rat small intestine immersed in a solution regarded as the serosal compartment was perfused in situ and the permeability of drugs into the mesenteric venous blood and into the serosal solution were determined. The cumulative amounts of salicylamide (SAM) transported to the mesenteric venous blood and the serosal compartment were 19.7 and 45.8% of amount disappeared from the intestinal lumen, respectively and those of benzoic acid (BA) were 47.4 and 12.7%, respectively. The permeability of SAM into the serosal compartment was 2.8 times of that into the mesenteric venous blood, while the permeability of BA into the serosal compartment was only one fourth of that into the mesenteric venous blood.
Oikawa
T
T
Central Research Laboratories, SS Pharmaceutical Co. Ltd., Chiba, Japan.
Shibasaki
S
S
Nishigaki
R
R
Umemura
K
K
D000818:Animals; D001565:Benzoates / Q000493:pharmacokinetics; D019817:Benzoic Acid; D007408:Intestinal Absorption; D008297:Male; D008954:Models, Biological; D010477:Perfusion; D010539:Permeability; D051381:Rats; D011919:Rats, Inbred Strains; D012457:Salicylamides / Q000493:pharmacokinetics*
D001565:Benzoates; D012457:Salicylamides; D019817:Benzoic Acid; C031060:salicylamide