[Association of HLA with breast cancer and its ER status].
Results of comparative study of HLA-A, -B typing in 73 patients with breast cancer (BC) who had different ER status and 50 healthy individuals in north China are reported. Of these 73 patients, HLA-C, -DR typing were also studied in 58 patients. The results showed that HLA-Bw61 (40) were negatively associated with BC but -Cw7 and -DRw6 were positively associated with BC. Moreover, -DRw6 was more closely associated with ER(+) status, with a RR value of 8.621. In the ER (-) group, there were no specific related antigens. In the light of the difference in pathology, prognosis and effect of endocrine therapy between ER (+) and ER (-), the authors believe that the two kinds of breast cancer may be a heterogeneous disease.
Song
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ST
Academy of Military Medical Sciences, Beijing.
D001943:Breast Neoplasms / Q000032:analysis* / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis; D015236:HLA-C Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D015808:HLA-DR6 Antigen; D006801:Humans; D011960:Receptors, Estrogen / Q000032:analysis*
D006680:HLA Antigens; D015235:HLA-B Antigens; C079077:HLA-B61 antigen; D015236:HLA-C Antigens; C040178:HLA-C*70 antigen; D006684:HLA-DR Antigens; D015808:HLA-DR6 Antigen; D011960:Receptors, Estrogen