title: Drosophila neuroglian: a member of the immunoglobulin superfamily with extensive homology to the vertebrate neural adhesion molecule L1.
abstract: Drosophila neuroglian is an integral membrane glycoprotein that is expressed on a variety of cell types in the Drosophila embryo, including expression on a large subset of glial and neuronal cell bodies in the central and peripheral nervous systems and on the fasciculating axons that extend along them. Neuroglian cDNA clones were isolated by expression cloning. cDNA sequence analysis reveals that neuroglian is a member of the immunoglobulin superfamily. The extracellular portion of the protein consists of six immunoglobulin C2-type domains followed by five fibronectin type III domains. Neuroglian is closely related to the immunoglobulin-like vertebrate neural adhesion molecules and, among them, shows most extensive homology to mouse L1. Its homology to L1 and its embryonic localization suggest that neuroglian may play a role in neural and glial cell adhesion in the developing Drosophila embryo. We report here on the identification of a lethal mutation in the neuroglian gene.
authors: Howard Hughes Medical Institute, University of California, Berkeley 94720.
authors: A J
authors: AJ
authors: Bieber
authors: P M
authors: PM
authors: Snow
authors: M
authors: M
authors: Hortsch
authors: N H
authors: NH
authors: Patel
authors: J R
authors: JR
authors: Jacobs
authors: Z R
authors: ZR
authors: Traquina
authors: J
authors: J
authors: Schilling
authors: C S
authors: CS
authors: Goodman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D005796:Genes; D005803:Genes, Immunoglobulin; D008562:Membrane Glycoproteins / Q000235:genetics*; D051379:Mice; D008854:Microscopy, Electron; D008969:Molecular Sequence Data; D005810:Multigene Family; D009420:Nervous System / Q000196:embryology / Q000378:metabolism / Q000648:ultrastructure; D012689:Sequence Homology, Nucleic Acid; D014714:Vertebrates
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D029721:Drosophila Proteins; D008562:Membrane Glycoproteins; C061745:Nrg protein, Drosophila; D004247:DNA