The effect of high-dose short-term ibuprofen on antihypertensive control with hydrochlorothiazide.
The effect of high-dose ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), on the blood pressure of treated hypertensive patients was evaluated in a randomized, placebo-controlled, double-blind, crossover trial with 24-hour ambulatory blood pressure monitoring. Twelve middle-aged black women with essential hypertension, controlled with 50 mg hydrochlorothiazide per day, randomly received 3200 mg ibuprofen and a placebo for 8 days. Each treatment phase was separated by a 1-week washout period. Ambulatory blood pressure monitoring (ABPM), body weight, and 24-hour urinary excretion of sodium, creatinine, and prostaglandin E2 (PGE2) were determined at the end of each treatment phase. Mean (+/- SEM) 24-hour systolic and diastolic blood pressures were 122/85 (+/- 2.9/1.7) and 125/85 (+/- 3.0/1.1) during the placebo and ibuprofen phases, respectively. Mean ABPM during six consecutive 4-hour periods also revealed no significant differences between placebo and ibuprofen. We conclude that 3200 mg ibuprofen per day for up to 1 week induced little change in blood pressure in hypertensive who are receiving hydrochlorothiazide.
Wright
J T
JT
Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0284.
McKenney
J M
JM
Lehany
A M
AM
Bryan
D L
DL
Cooper
L W
LW
Lambert
C M
CM
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D015232:Dinoprostone / Q000652:urine; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D015716:Electrocardiography, Ambulatory / Q000187:drug effects; D004573:Electrolytes / Q000652:urine; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D011863:Radioimmunoassay; D011897:Random Allocation
D004573:Electrolytes; D006852:Hydrochlorothiazide; D015232:Dinoprostone; D007052:Ibuprofen