title: Effects of gossypol on Na+, K+ transmembrane fluxes in human red cells.
abstract: The effects of gossypol-acetic acid (a male contraceptive) on transmembrane fluxes of sodium and potassium in human red cells were studied, in comparison with the effects of ouabain (an inhibitor of Na+-K+-ATPase) and furosemide (an inhibitor of Na+, K+ cotransport). It was found that gossypol may be an inhibitor of outward (Na+, K+) cotransport in human red cells but has no significant effect on (Na+, K+)-ATPase. The results provide new evidence for elucidating the mechanism of hypokalemia caused by gossypol.
authors: Y
authors: Y
authors: Jin
authors: H C
authors: HC
authors: Chen
authors: W H
authors: WH
authors: Wo
authors: M Z
authors: MZ
authors: Yang
authors: S P
authors: SP
authors: Xue
mesh_terms: D004910:Erythrocyte Membrane / Q000378:metabolism*; D006072:Gossypol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D011188:Potassium / Q000493:pharmacokinetics*; D012964:Sodium / Q000493:pharmacokinetics*
chemical_list: D012964:Sodium; D006072:Gossypol; D011188:Potassium; C028178:gossypol acetic acid