[Development of motor and emotional disorders in rats during daily administration of subliminal doses of picrotoxin].
It was shown in the experiments on rats, that three neuropathological syndromes develop as a result of daily subthreshold picrotoxin injections (1.25 mg/kg). Maximal expression of syndromes was different during various periods of kindling. The development of seizure syndrome was followed by prevalence of enhanced electrical activity in hippocampus; the development of "akinetic" syndrome was the same in the caudate nuclei. Data are discussed on the positions of theory of the generator, determinant and systemic mechanisms of neuropathological syndromes.
Kryzhanovskiĭ
G N
GN
Shandra
A A
AA
Makul'kin
R F
RF
Godlevskiĭ
L S
LS
Mazarati
A M
AM
D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000503:physiopathology; D004562:Electrocardiography; D004644:Emotions; D007696:Kindling, Neurologic; D008297:Male; D009069:Movement Disorders / Q000503:physiopathology; D010852:Picrotoxin / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013577:Syndrome; D013997:Time Factors
D010852:Picrotoxin
Formirovanie dvigatel'nykh i émotsional'nykh rasstroĭstv u krys pri ezhednevnom vvedenii pikrotoksina v podporogovĭ doze.