Evidence for the involvement of prostaglandins in modulation of acetylcholine release from canine bronchial tissue.
A sensitive high pressure liquid chromatography (HPLC) method was used to measure acetylcholine release from canine bronchial tissue in response to electrical stimulation. Indomethacin enhanced the efflux of acetylcholine, an effect that was reversed by the addition of prostaglandin E2 (PGE2). Prostaglandin D2 (PGD2) had no effect on acetylcholine output. These data suggest that prostaglandins, possibly PGE2, are involved in a negative feedback control mechanism for acetylcholine release in canine bronchi.
Deckers
I A
IA
University of Antwerp (UIA), Department of Experimental Pharmacology, Wilrijk, Belgium.
Rampart
M
M
Bult
H
H
Herman
A G
AG
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D015232:Dinoprostone / Q000494:pharmacology; D004285:Dogs; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008168:Lung / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D015230:Prostaglandin D2 / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology*
D011453:Prostaglandins; D001285:Atropine; D015232:Dinoprostone; D000109:Acetylcholine; D015230:Prostaglandin D2; D007213:Indomethacin