[Changes in biliary lithogenicity caused by 4 weeks' weight reduction].
In 2 of 12 patients (16.6%) cholesterol monohydrate crystals occurred in duodenal bile samples after a 4 weeks fasting period (452 kcal/day). Cholesterol monohydrate crystals could be observed until recently mainly in patients with cholesterol gallstones. Therefore, this finding indicates increased biliary lithogenicity despite a non statistical decrease in CSI from 1.35 +/- 0.35 to 1.19 +/- 0.64. Presumably the increased lithogenicity may be caused by an increased glycoprotein concentration and an improvement in gallbladder contractility. Short time fasting obviously will be a risk factor for the development of gallstones, if weight and metabolic normalisation cannot be achieved.
Janowitz
P
P
Abteilung Innere Medizin II der Universität Ulm.
Swobodnik
W
W
Wechsler
J G
JG
Kuhn
K
K
Wenzel
H
H
Wenk
H
H
Ditschuneit
H
H
D000328:Adult; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D002769:Cholelithiasis / Q000209:etiology* / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000178:diet therapy / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D015431:Weight Loss
D001647:Bile Acids and Salts; D010743:Phospholipids; D002784:Cholesterol
Veränderungen der biliären Lithogenität während einer vierwöchigen Gewichtsreduktion.