Proanthocyanidins from Krameria triandra root.
Oligomeric proanthocyanidins were isolated from rhatany root (Krameria triandra) and characterised by acid hydrolysis, thiolytic degradation, and spectroscopic methods. They consisted of 2-14 flavanol units with mainly 2,3-cis configuration and with a propelagonidin:procyanidin ratio of 65:35. The predominant interflavan linkage was [4,8]. [4,6]-Bonds were present in the higher oligomers, presumably forming branched chain units. The astringency of the drug was mainly due to proanthocyanidins with degrees of polymerization from 5-10, and these were also the astringent compounds of rhatany tea and tincture. A pharmacological screening of the extract revealed a significant antimicrobial effect.
Scholz
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Rimpler
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D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification; D055598:Chemical Phenomena; D002621:Chemistry; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D011918:Rats, Inbred SHR
D000890:Anti-Infective Agents; D005419:Flavonoids