[The distribution of 3H-alpha-sec-butyl-p hydroxybenzyl alcohol in mice].
alpha-sec-butyl-p-hydroxybenzyl alcohol is a derivative of gastrodigenin. It dissolves in lipid and passes through the blood-brain barrier more easily than gastrodin does. The distribution experiment has demonstrated that 3H-alpha-sec-butyl-p-hydroxybenzyl alcohol in the brain of mice is higher than in other organs, such as the liver, kidney and intestines. Radioactivity of brain tissue rises to the highest peak in about 1/2-2 min after intravenous injection. Each gram of the brain tissue takes up 21.89% radioactivity of the total dose administered. The sedative effect of alpha-sec-butyl-p-hydroxybenzyl alcohol on the center is rapid and short. It has been proved by the reactions in mice, results indicated by the electrocorticogram obtained from the mice after giving alpha-sec-butyl-p-hydroxybenzyl alcohol, and the correspondence with the distribution of alpha-sec-butyl-p-hydroxybenzyl alcohol in the mouse brain.
Tan
T Z
TZ
Kuang
A R
AR
Liang
Z L
ZL
Zhong
Y G
YG
Chai
H X
HX
Zhang
J L
JL
D000818:Animals; D001592:Benzyl Alcohols / Q000493:pharmacokinetics*; D001593:Benzyl Compounds / Q000493:pharmacokinetics*; D004569:Electroencephalography; D005260:Female; D006993:Hypnotics and Sedatives / Q000493:pharmacokinetics*; D051379:Mice; D014018:Tissue Distribution; D014316:Tritium
D001592:Benzyl Alcohols; D001593:Benzyl Compounds; D006993:Hypnotics and Sedatives; D014316:Tritium; C061385:4-hydroxy-alpha-(1-methylpropyl)benzenemethanol