A barley flour inhibitor of insect alpha-amylase is a major allergen associated with baker's asthma disease.
A barley salt-soluble protein of 14.5 kDa, which inhibits the alpha-amylase from the insect Tenebrio molitor, has been identified as a major IgE-binding component of sera from baker's asthma patients. The N-terminal amino acid sequence of this protein indicates that it is a member of a previously described family of alpha-amylase/trypsin inhibitors.
Barber
D
D
Departamento de Análisis, Alergía e Inmunologia Abelló, ETS Ingenieros Agrónomos, Madrid, Spain.
Sánchez-Monge
R
R
Gómez
L
L
Carpizo
J
J
Armentia
A
A
López-Otín
C
C
Juan
F
F
Salcedo
G
G
D000485:Allergens / Q000009:adverse effects / Q000302:isolation & purification*; D000595:Amino Acid Sequence; D000818:Animals; D001249:Asthma / Q000139:chemically induced*; D002851:Chromatography, High Pressure Liquid; D002523:Edible Grain / Q000032:analysis*; D004586:Electrophoresis / Q000379:methods; D005433:Flour / Q000009:adverse effects / Q000032:analysis*; D001467:Hordeum / Q000009:adverse effects / Q000032:analysis*; D007313:Insecta / Q000201:enzymology; D008969:Molecular Sequence Data; D009784:Occupational Diseases / Q000139:chemically induced*; D014361:Trypsin Inhibitors / Q000009:adverse effects / Q000302:isolation & purification*; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
D000485:Allergens; D014361:Trypsin Inhibitors; D000516:alpha-Amylases