The effects of the bioflavonoid quercetin on squamous cell carcinoma of head and neck origin.
Quercetin exhibits antitumor activity. We investigated the effect of quercetin on the in vitro and in vivo growth of two squamous cell carcinoma cell lines and a normal human lung fibroblast-like cell line. The in vivo effect was evaluated using implantable cell growth chambers implanted subcutaneously in immunocompetent rats. Quercetin was injected intraperitoneally, and multiple dosages were tested. Cells were counted on days 1, 3, 5, and 7, and growth curves were constructed. Quercetin caused inhibition of growth in both squamous cell carcinoma lines. Effect on the fibroblast-like human lung cells was noted only at the maximum concentration. Significant growth inhibition of squamous cell carcinoma was observed in implantable cell growth chambers retrieved 3 days after quercetin treatment. Quercetin appears to possess a cytotoxic effect on squamous cell carcinoma of head and neck origin both in vivo and in vitro. The inhibitory effect on malignant cells appears to be selective and dose-dependent.
Castillo
M H
MH
Department of Otolaryngology, State University of New York, Sisters of Charity Hospital, Buffalo, New York.
Perkins
E
E
Campbell
J H
JH
Doerr
R
R
Hassett
J M
JM
Kandaswami
C
C
Middleton
E
E
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D015194:Diffusion Chambers, Culture; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000494:pharmacology*; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011794:Quercetin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014407:Tumor Cells, Cultured / Q000187:drug effects
D005419:Flavonoids; D006131:Growth Inhibitors; D011794:Quercetin