Kinetics of methyl mercury in blood and brain during chronic exposure in the monkey Macaca fascicularis.
The disposition parameters derived from a compartmental model kinetic analysis of blood Hg levels in nonpregnant, adult female Macaca fascicularis given daily doses of MeHg did not vary with either dosage level (50, 70 or 90 micrograms MeHg/kg b.wt.day) or duration of exposure (up to 507 day). In contrast, blood clearance of Hg in pregnant females was dose-dependent; it being higher at the 90 micrograms MeHg/kg b.wt.day than at the lower dosage levels. Hg levels in the brain of adult fascicularis relative to blood Hg also increased at the highest level of exposure. Blood Hg half-life in neonate fascicularis was similar to half-life in their mothers (adults). Finally, the regional distribution of mercury in the brains of adult and neonate fascicularis exposed to low and intermediate levels of MeHg resembles the reported distribution of mercury in the brains of adult and neonate humans environmentally exposed to MeHg. Consequently, M. fascicularis may be an especially appropriate animal model for studying the neurotoxic mechanisms of chronic methyl mercury exposure.
Stinson
C H
CH
Department of Pathology, University of Washington, Seattle 98195.
Shen
D M
DM
Burbacher
T M
TM
Mohamed
M K
MK
Mottet
N K
NK
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D008252:Macaca fascicularis; D008767:Methylmercury Compounds / Q000097:blood / Q000493:pharmacokinetics*; D011247:Pregnancy; D014018:Tissue Distribution
D008767:Methylmercury Compounds