Intrahepatic 5-FU retreatment of liver metastases of colorectal cancer that were progressive under previous systemic chemotherapy.
Sixteen patients with liver metastases of colorectal cancer that were progressive under systemic chemotherapy were treated by hepatic arterial infusion therapy. 5-fluorouracil (5-FU) with a daily dosage of 1 g/m2/day was given continuously for 5 consecutive days at 3-week intervals. Restaging after three cycles of treatment revealed three partial remissions (PRs) and five patients with stable disease (SD). Duration of response was a median 17 months in patients with PRs. Survival time of the total group of patients was 11.6 months. Patients with PRs had 19 months, patients with SD 13 months, and patients with progressive disease 9 months median survival time. In 12 of the patients, tumor growth was limited to the liver for a long period of time, and extrahepatic metastases occurred in the end-stage disease. Therefore, in patients with progressive liver metastases of colorectal cancer under systemic chemotherapy and with no extrahepatic metastases, intrahepatic arterial chemotherapy may offer a further chance for tumor control.
Hohenberger
P
P
Department of Surgery, University of Heidelberg, Germany.
Schlag
P
P
Herrmann
R
R
Räth
U
U
D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D000328:Adult; D000368:Aged; D002423:Cause of Death; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012074:Remission Induction; D014057:Tomography, X-Ray Computed
D005472:Fluorouracil