Effect of levodopa on the human pattern electroretinogram and pattern visual evoked potentials.
Pattern electroretinograms (P-ERGs) and pattern visual evoked potentials (P-VEPs) were recorded at three luminance levels and five different check sizes in a group of 16 control subjects before and after the oral administration of levodopa. At the lower luminance levels, significant decrease in P-ERG and P-VEP latencies were found. For P-VEPs the latency changes occurred only at small check sizes. No changes were observed in control experiments without levodopa administration. Our results show that levodopa-induced changes even occur at the retinal level and support a dopaminergic involvement in light and dark adaptation. Our observations are in agreement with a VEP delay found in Parkinson's disease and with a VEP latency increase in rats after dopamine depletion.
Gottlob
I
I
I. Universitäts-Augenklinik, Wien, Austria.
Weghaupt
H
H
Vass
C
C
Auff
E
E
D000284:Administration, Oral; D000328:Adult; D004596:Electroretinography / Q000187:drug effects*; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D005260:Female; D005556:Form Perception; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010364:Pattern Recognition, Visual / Q000187:drug effects*; D011897:Random Allocation; D013997:Time Factors; D014792:Visual Acuity
D007980:Levodopa