title: Ibotenic acid-induced nigral lesion and limbic seizure in cats.
abstract: The degenerative lesions of bilateral substantia nigra (SN) were made by means of microinjections of ibotenic acid (IBO) solutions and influences upon kainic acid (KA)-induced seizures were studied. IBO solutions were injected bilaterally into SN and circumscribed degenerative lesions were made within the bilateral SN. In a control group, phosphate buffer solutions were injected in the bilateral SN. More than one week after the procedures, 1 microgram KA was injected into unilateral amygdala via implanted cannula and limbic seizures were induced. The destruction of SN accelerated the secondary generalization of the limbic seizure within 3 days after the KA injection while no secondary generalization was observed within 3 days in the control group. The fact suggests that GABAergic systems of the substantia nigra and/or ascending norepinephrine pathway have a strong inhibitory influence on the secondary generalization of limbic seizures. The hypothesis of nigral mechanisms as a control system for secondary generalization is discussed.
authors: Department of Neurosurgery, Asahikawa Medical College, Japan.
authors: T
authors: T
authors: Tanaka
authors: S
authors: S
authors: Tanaka
authors: M
authors: M
authors: Kaijima
authors: Y
authors: Y
authors: Yonemasu
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000503:physiopathology*; D002415:Cats; D004569:Electroencephalography; D005260:Female; D007051:Ibotenic Acid; D007608:Kainic Acid; D008032:Limbic System / Q000503:physiopathology*; D008297:Male; D010080:Oxazoles; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013378:Substantia Nigra / Q000502:physiology*
chemical_list: D010080:Oxazoles; D007051:Ibotenic Acid; D007608:Kainic Acid