title: Keloid fibroblasts in culture: abnormal growth behaviour and altered response to the epidermal growth factor.
abstract: Keloid fibroblasts were propagated in culture and their proliferative behaviour and response to the Epidermal Growth Factor (EGF) were studied. Keloid fibroblasts grew at a rate which was approximately one-half that of normal age, sex and race matched control fibroblasts. Keloid fibroblasts were stimulated to grow in the presence of EGF (10 ng/ml), but to a lesser degree than the normal control fibroblasts. Scatchard analysis of the binding data obtained using 125I-labeled EGF revealed no difference in binding affinity or receptor numbers between keloid and normal fibroblasts.
authors: Connective Tissue Research Institute, University City Science Center, Philadelphia, Pennsylvania 19104.
authors: R A
authors: RA
authors: Harper
mesh_terms: D000328:Adult; D002455:Cell Division; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D007627:Keloid / Q000378:metabolism / Q000473:pathology*; D012867:Skin / Q000166:cytology; D013997:Time Factors
chemical_list: D004815:Epidermal Growth Factor