Intraocular non-Hodgkin's lymphoma treated with systemic and intrathecal chemotherapy and radiotherapy. A case report and review of the literature.
A case of therapy-resistant bilateral intermediate uveitis is presented. Vitreous biopsy and lumbar puncture resulted in the diagnosis of high-grade malignant non-Hodgkin's lymphoma (NHL). Because chemotherapy and radiotherapy continue to yield better results in the treatment of NHL and a cure can be reached in a large group of patients with high-grade malignant NHL, early diagnosis is very important. We therefore recommend early vitreous biopsy in persistent, bilateral, granulomatous intermediate uveitis, especially in older patients. Our patient achieved a complete remission (follow-up period at the time of writing, 18 months after the beginning of polychemotherapy and radiotherapy). The chemotherapy modalities are briefly discussed.
Rouwen
A J
AJ
Department of Ophthalmology, Free University Hospital, Amsterdam, The Netherlands.
Wijermans
P W
PW
Boen-Tan
T N
TN
Stilma
J S
JS
D000971:Antineoplastic Combined Chemotherapy Protocols; D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use*; D004317:Doxorubicin / Q000627:therapeutic use; D005134:Eye Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D002955:Leucovorin / Q000627:therapeutic use; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000532:radiotherapy; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012164:Retinal Diseases / Q000188:drug therapy / Q000473:pathology*; D014605:Uveitis / Q000150:complications; D014750:Vincristine / Q000627:therapeutic use; D014792:Visual Acuity; D014822:Vitreous Body / Q000473:pathology
D003561:Cytarabine; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002955:Leucovorin; D011241:Prednisone; D008727:Methotrexate