[Clinical and experimental research on a kidney-tonifying prescription in preventing and treating children's hearing-loss induced by aminoglycoside antibiotic ototoxicity].
This paper reports 30 cases of hearing-loss induced by aminoglycoside antibiotic ototoxicity treated mainly with Kidney-tonifying herbs such as Herba Epimedii, Rhizoma Drynariae, Rhizoma Polygonati, Radix Polygoni Multiflori, Magnetitum and Rhizoma Acori Graminei, etc. After three month's treatment, the authors found that 19 cases had improved their hearing more than 15 db, among which there are 8 cases who had improved 15 db and 11 cases 30 db. The patients' hearing of pre-treatment and post-treatment were determined by BAR V-wave hearing threshold. In order to further prove that Kidney-tonifying prescription can antagonize the aminoglycoside antibiotic ototoxicity, animal experiments had been made. The authors chose guinea pigs for experimental animals, which were randomly divided into three groups: Kanamycin group, kanamycin with Kidney-tonifying herbs group, and control group. The indexes of the experiments were the animals' helix reflection index, BAR and observation of animals' cochlear under electron microscope. As a result, the damage to hair cell of Cortis organ has marked for the animals of kanamycin group, while for kanamycin with herbs group, it was obviously slighter (P less than 0.01). There was significant difference between the groups. The result indicates that Kidney-tonifying herbs had the effect of protecting the animals' hair cells of cortis organ against aminoglycoside antibiotic ototoxicity and thus protected the animals' hearing.
Lin
W S
WS
Song
X Z
XZ
D000293:Adolescent; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D005839:Gentamicins / Q000009:adverse effects; D006168:Guinea Pigs; D034381:Hearing Loss; D006312:Hearing Loss, Bilateral / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009925:Organ of Corti / Q000187:drug effects
D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D005839:Gentamicins