Trophic factors and Alzheimer's disease.
The paper by Butcher and Woolf presents a troubling hypothesis, that neurotrophic factors may be contributory to the pathology of Alzheimer's disease rather than potentially serving as therapeutic agents. Much more experimental work, especially in primates, will be required to tease out the positive and/or negative influences these factors may have on the pathogenesis of the neurodegenerative diseases causing dementias.
Phelps
C H
CH
Neuroscience and Neuropsychology of Aging Program, National Institute on Aging, Bethesda, MD 20892.
D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use
D009414:Nerve Growth Factors