[An amino acid substitution determining G1m(x) allotypic marker].
We confirmed the amino acid substitution responsible for G1m(x) allotypic marker, which was estimated by Cook & Steinberg (Mol. Immunol. 16:555-558 (1979), by primary structure analysis of the C-terminal BrCN peptide from normal human IgG1 carrying G1m(x+) or G1m(x-). The results indicate that IgG1 carrying G1m(x) have glycine instead of alanine at position 431 (Eu numbering). And we discussed the epitope on tertiary structure of IgG1-Fc fragment.
Ito
S
S
Suzuki
K
K
Miyazaki
T
T
Matsumoto
H
H
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis*; D005819:Genetic Markers / Q000032:analysis; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000032:analysis / Q000235:genetics; D007074:Immunoglobulin G / Q000032:analysis / Q000235:genetics; D007129:Immunoglobulin Gm Allotypes / Q000032:analysis* / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure
D000596:Amino Acids; D005819:Genetic Markers; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007129:Immunoglobulin Gm Allotypes