title: Effects of mezerein and diglycerides on the PRL stimulation of cell replication in Nb2 node lymphoma cells.
abstract: These studies provide further support for the thesis that the activation of protein kinase C is likely involved in the prolactin (PRL) stimulation of mitogenesis in the Nb2 node lymphoma cell line. The diterpene mezerein is shown to potentiate the mitogenic effect of PRL at a hormone concentration which elicits a less than maximum response. A similar response was observed with two diglycerides, diolein and dicaprin. Neither mezerein nor the diglycerides affected the magnitude of response to a maximum stimulatory concentration of PRL.
authors: Department of Physiology, Wayne State University, School of Medicine, Detroit, Michigan 48201.
authors: T M
authors: TM
authors: Tarrant
authors: J A
authors: JA
authors: Rillema
mesh_terms: D002273:Carcinogens / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004075:Diglycerides / Q000494:pharmacology*; D004224:Diterpenes; D004357:Drug Synergism; D004789:Enzyme Activation / Q000187:drug effects; D005989:Glycerides / Q000494:pharmacology*; D007700:Kinetics; D008223:Lymphoma / Q000473:pathology*; D011388:Prolactin / Q000494:pharmacology*; D011493:Protein Kinase C / Q000378:metabolism*; D013729:Terpenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D002273:Carcinogens; D004075:Diglycerides; D004224:Diterpenes; D005989:Glycerides; D013729:Terpenes; C044297:1,2-didecanoylglycerol; C011309:mezerein; C038237:1-oleoyl-2-acetylglycerol; D011388:Prolactin; D011493:Protein Kinase C; C013965:diolein