title: Familial deficiency of the seventh component of complement associated with recurrent meningococcal infections.
abstract: We describe an 11-year-old girl suffering from recurrent meningitis with a complete absence of the seventh component of complement (C7). Diagnosis was established by haemolytic titration and western blotting. The patient's serum lacked the 85 kDa C7 chain. Haemolytic activity of serum was reconstituted with either pooled normal human serum or with purified C7. The relatives (parents and one sister) had half-normal levels of both immunochemically and functionally determined C7, indicating a heterozygous state for C7 deficiency.
authors: Abteilung für Neonatologie und Gastroenterologie der Universität, Düsseldorf, Federal Republic of Germany.
authors: W
authors: W
authors: Nürnberger
authors: H
authors: H
authors: Pietsch
authors: R
authors: R
authors: Seger
authors: T
authors: T
authors: Bufon
authors: V
authors: V
authors: Wahn
mesh_terms: D015153:Blotting, Western; D002648:Child; D003184:Complement C7 / Q000172:deficiency* / Q000235:genetics; D005260:Female; D006801:Humans; D008585:Meningitis, Meningococcal / Q000276:immunology*; D012008:Recurrence
chemical_list: D003184:Complement C7