Regional brain glucose metabolism in neuroacanthocytosis.
Two brothers with neuroacanthocytosis had [18F]-2-fluoro-2-deoxyglucose PET scans showing marked glucose hypometabolism of the caudate and putamen. MRIs showed no evidence of atrophy or modification of signal intensity in these structures. Decreased glucose utilization of the striatum can underlie hyperkinetic movement disorders of various etiologies.
Dubinsky
R M
RM
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
Hallett
M
M
Levey
R
R
Di Chiro
G
G
D000050:Acanthocytes; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D004913:Erythrocytes, Abnormal; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006402:Hematologic Diseases / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D009069:Movement Disorders / Q000378:metabolism*; D012640:Seizures / Q000378:metabolism* / Q000473:pathology; D013577:Syndrome; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose