Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for psoriatic arthropathy.
A case of Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for psoriasis and psoriatic arthropathy is described. This potentially fatal event was probably precipitated by an interaction between methotrexate and concurrent non-steroidal anti-inflammatory drugs, resulting in serious potentiation of the effects of methotrexate.
Wallis
P J
PJ
Department of Medicine, Manor Hospital, Walsall, West Midlands.
Ryatt
K S
KS
Constable
T J
TJ
D000293:Adolescent; D001168:Arthritis / Q000188:drug therapy*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000009:adverse effects; D007165:Immunosuppression Therapy / Q000009:adverse effects; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D011020:Pneumonia, Pneumocystis / Q000209:etiology*; D011565:Psoriasis / Q000188:drug therapy*
D007052:Ibuprofen; D008727:Methotrexate