Cochlear nerve action potentials during cerebellopontine angle surgery: relationship of latency, amplitude, and threshold measurements to hearing.
The cochlear nerve action potential (AP) was monitored during two types of hearing preservation surgery: (1) removal of small cerebellopontine angle tumors and (2) retrolabyrinthine vestibular nerve section. The purpose of this investigation was to study the relationship between changes in intraoperative AP latency, amplitude, and threshold, and changes in audiometric hearing subsequent to surgery. The presence or absence of a cochlear nerve AP toward the end of surgery accurately predicted the presence or absence of postoperative hearing (93%). Regression analyses were performed to explore the relationship between audiometric pre- and postoperative thresholds and intraoperative AP threshold changes. Statistically significant relationships were found for (1) pre-operative audiometric thresholds and initial AP click thresholds (p = 0.0068); (2) final AP click thresholds and postoperative audiometric thresholds (p = 0.0003); (3) AP click (p = 0.0001) and 1 kHz (p = 0.0006) threshold shifts and pre- to postoperative audiometric threshold shifts. No relationship was found between either AP latency or amplitude values and postoperative hearing. Intraoperative threshold measurements can be used as an indicator of hearing change. If amplitude or latency indices are also monitored it may be better to use stimulus levels close to the evoked potential threshold.
Stanton
S G
SG
Department of Otolaryngology, Sunnybrook Medical Centre, University of Toronto, Ontario, Canada.
Cashman
M Z
MZ
Harrison
R V
RV
Nedzelski
J M
JM
Rowed
D W
DW
D000200:Action Potentials; D001299:Audiometry; D001309:Auditory Threshold / Q000502:physiology*; D002528:Cerebellar Neoplasms / Q000601:surgery*; D002530:Cerebellopontine Angle / Q000601:surgery*; D003056:Cochlear Nerve / Q000502:physiology*; D005072:Evoked Potentials, Auditory; D006309:Hearing / Q000502:physiology*; D006801:Humans; D009464:Neuroma, Acoustic / Q000601:surgery*; D014717:Vertigo / Q000601:surgery; D014725:Vestibular Nerve / Q000601:surgery