Enhanced in vitro bone marrow cell migration and T-lymphocyte responses in aged mice given subcutaneous thymic epithelial cell grafts.
Thymic epithelial cell cultures from newborn CBA/J mice were developed and grown on collagen-coated dextran beads. These thymic epithelial cells were transplanted subcutaneously into aged syngeneic mice. After several weeks, enhanced in vitro migration of host bone marrow cells occurred to supernatants prepared from neonatal thymus cultures in thymic epithelial cell grafted mice compared to control aged mice. Percent migration equaled that of migration from control young adult mice. In addition, enhanced T-lymphocyte responses were observed in aged mice given thymic epithelial cell grafts as compared to aged controls.
Haar
J L
JL
Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
Taubenberger
J K
JK
Doane
L
L
Kenyon
N
N
D000375:Aging / Q000276:immunology*; D000818:Animals; D001853:Bone Marrow / Q000276:immunology / Q000502:physiology*; D002465:Cell Movement; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D007108:Immune Tolerance; D051379:Mice; D008808:Mice, Inbred CBA; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology / Q000637:transplantation*
D003208:Concanavalin A