[Halothane anesthesia of several hours' duration in swine of the German Landrace breed, selected for resistance to malignant hyperthermia].
The malignant hyperthermia syndrome is widely spread in pigs of the German Landrace. This has precluded the use of halothane anesthesia. The advent of homozygous halothane-negative strains stimulated us to test whether such animals were suitable for longduration halothane anesthesia. Nine sows of the German Landrace (n = 4, homozygous halothane-positive (H+); n = 5, homozygous halothane-negative (-)) were used. Anesthesia was induced by Azaperon/Metomidat-HCL followed by intubation and exposure to halothane. All 4 halothane-positive animals died within 45-90 min following the onset of halothane administration, while all 5 halothane-negative animals survived a 4-5 h deep anesthesia without problems. Thus, homozygous hylothane-positive strains of German Landrace pigs may be surgically anesthetized for long durations with halothane anesthesia.
Nowak
R
R
Ellendorff
F
F
D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D001947:Breeding; D005260:Female; D006221:Halothane / Q000009:adverse effects; D006720:Homozygote; D008305:Malignant Hyperthermia / Q000209:etiology / Q000235:genetics / Q000662:veterinary*; D013552:Swine / Q000235:genetics; D013553:Swine Diseases / Q000209:etiology* / Q000235:genetics; D013997:Time Factors
D006221:Halothane
Mehrstündige Halothannarkose bei Schweinen der Deutschen Landrasse, die gegen maligne Hyperthemie selektiert wurden.