[Evaluation of serum pepsinogen I and II of patients with gastric cancer].
Serum pepsinogen levels were examined by immunoradiometric assay method for evaluating its clinical usefulness in gastric cancer. In patients with gastric cancer, serum PG-I tended to decrease but PG-II stayed normal level, resulting in low PG-I/PG-II ratio. Combination of PG-I and PG-I/PG-II discriminated 53.7% of gastric cancer, 70.6% of scirrhous type gastric cancer, and 66.7-100% of those arisen in the upper portion of the stomach, but 13.7% of normal subjects. As the aged normal subjects tended to show decreased PG-I/PG-II ratio (about 30% of the normal subjects aged over 40 years were discriminated as abnormal), the usefulness for detection of gastric cancer seems to be limited, but some types of gastric cancer such as scirrhous type or one arisen in the upper portion may be discriminated by this method. It is also suggested that this method may detect the recurrence of the cancer in some patients.
Kimura
Y
Y
Fujii
T
T
Hamamoto
K
K
Miyagawa
N
N
Tsuda
K
K
Tanada
S
S
Iio
A
A
D000328:Adult; D000367:Age Factors; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010435:Pepsinogens / Q000097:blood*; D013274:Stomach Neoplasms / Q000201:enzymology*
D002272:Carcinoembryonic Antigen; D010435:Pepsinogens