In vivo evidence of interaction between interferon-stimulated gene factors and the interferon-stimulated response element.
Constitutive and interferon-inducible DNase hypersensitive sites in vivo are located in interferon-stimulated gene promoters near sequences that specifically bind constitutive or interferon-inducible proteins in vitro. Induced sites and proteins are transient or maintained, depending on cell type. Interferon-stimulated gene transcription is transient or maintained in parallel.
Pine
R
R
Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021.
Darnell
J E
JE
D002460:Cell Line; D002467:Cell Nucleus / Q000032:analysis; D002843:Chromatin / Q000648:ultrastructure; D004268:DNA-Binding Proteins; D003850:Deoxyribonuclease I; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D011401:Promoter Regions, Genetic; D011994:Recombinant Proteins; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors
D002843:Chromatin; D004268:DNA-Binding Proteins; D007370:Interferon Type I; D011994:Recombinant Proteins; D014157:Transcription Factors; D003850:Deoxyribonuclease I