Cytotoxic isoquinoline alkaloids from Xanthorhiza simplicissima.
Two cytotoxic isoquinoline alkaloids, liriodenine and palmatine, were isolated from the Xanthorhiza simplicissima Marsh. Liriodenine, isolated for the second time from the family of Ranunculaceae, demonstrated potent cytotoxicity against KB, A-549, HCT-8, P-388, and L-1210 tumor cells, while palmatine showed marginal cytotoxicity against KB cells.
Wu
Y C
YC
Yamagishi
T
T
Lee
K H
KH
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D001060:Aporphines / Q000494:pharmacology; D001600:Berberine Alkaloids / Q000494:pharmacology; D006801:Humans; D051379:Mice
D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; D001600:Berberine Alkaloids; C026980:liriodenine; C005413:palmatine