Prevention of rectal cancer induced by N-nitrosobis(2-oxopropyl)-amine by exogenous testosterone in MRC rats.
Rectal carcinogenicity of N-nitrosobis(2-oxopropyl)amine (BOP) in male MRC Wistar rats was shown to be inhibited by exogenous testosterone (T) when the hormone was given during, but not after, administration of the carcinogen. This effect was independent of the dose and frequency of BOP, which was given either weekly for 20 weeks orally or daily for 3 days subcutaneously. Since, except for prostatic cancer, the incidence and the patterns of other BOP-induced tumors were not altered by T, this hormone seems to play a specific role in the rectal carcinogenesis of BOP.
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Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68105.
Kazakoff
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D000818:Animals; D009602:Nitrosamines; D051381:Rats; D012004:Rectal Neoplasms / Q000139:chemically induced*; D016019:Survival Analysis; D013739:Testosterone / Q000494:pharmacology*
D009602:Nitrosamines; D013739:Testosterone; C013622:nitrosobis(2-oxopropyl)amine