Acquired immunity in rats against Angiostrongylus cantonensis infection.
Acquired immunity against Angiostrongylus cantonensis was induced by immunizing rats with somatic antigens from fifth-stage larvae and adult worms and live third-stage larvae. Rats immunized twice had significantly fewer worms than rats immunized three times. Fewer worms were recovered from rats immunized with 200 live third-stage larvae than from any other groups. Rats immunized with somatic antigens had higher enzyme-linked immunosorbent assay (ELISA) antibody levels than rats immunized with live larvae. Rats immunized with live third-stage larvae of Angiostrongylus cantonensis were more strongly protected against challenge infections (62-92%) than rats immunized with antigens extracted from fifth-stage larvae (0-30%) and adult worms (11-24%).
Wang
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Chao
D
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Chen
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D000801:Angiostrongylus / Q000276:immunology*; D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis*; D007110:Immunity, Active; D007814:Larva / Q000276:immunology; D008681:Metastrongyloidea / Q000276:immunology*; D009349:Nematode Infections / Q000276:immunology / Q000662:veterinary*; D051381:Rats; D011919:Rats, Inbred Strains / Q000469:parasitology*; D012376:Rodent Diseases / Q000276:immunology*
D000909:Antibodies, Helminth