Regulation of immunoglobulin gene rearrangement and expression.
The molecular genetic events leading to Ig expression and their control formed the topic of a recent EMBO workshop. This report by Michael Taussig, Martin Sims and Ulrich Krawinkel discusses contributions dealing with genes expressed in early pre-B cells, the mechanism of rearrangement, aberrant rearrangements seen in B cells of SCID mice, the feedback control of rearrangement as studied in transgenic mice, the control of Ig expression at the transcriptional and post-transcriptional levels, and class switching.
Taussig
M J
MJ
Sims
M J
MJ
Krawinkel
U
U
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D004742:Enhancer Elements, Genetic; D005246:Feedback; D005786:Gene Expression Regulation; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D051379:Mice; D008817:Mice, Mutant Strains