A comparative study of prenatal development in the olfactory bulb, neocortex and hippocampal region of the precocial mouse Acomys cahirinus and rat.
Unlike the remainder of the rodent subfamily Muridae, Acomys cahirinus (the 'spiny' mouse) is born in a precocial state after a long (39 day) gestation. In this paper, the development of the olfactory bulb, neocortex and hippocampal formation of Acomys from prenatal days 14-34 was examined and the rate of maturation compared with that of its cousin, the laboratory rat (Rattus norvegicus). At the earliest stages examined, Acomys was approximately 2 days less mature than the same post-conception aged rat. The difference between the two species increased: Acomys at 28 days postconception resembled the 22-day rat. By the end of gestation, Acomys and the rat were in a relatively similar developmental state. Therefore, Acomys exhibits a quite different timetable of early maturation which includes a protracted period of relatively slow growth during mid-gestation. As such, it offers many benefits as a subject for studies of both early ontogenesis and the mechanisms which result in species differences.
Brunjes
P C
PC
Department of Psychology, University of Virginia, Charlottesville 22903.
D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology*; D005314:Embryonic and Fetal Development; D005865:Gestational Age; D006624:Hippocampus / Q000166:cytology / Q000196:embryology*; D051379:Mice; D009830:Olfactory Bulb / Q000166:cytology / Q000196:embryology*; D051381:Rats