title: Impaired down-regulation of pituitary dopamine receptors by estradiol in aged rats.
abstract: Administration of 17 beta-estradiol to mature (6-12 months) rats results in a more than 50% reduction in pituitary dopamine receptor concentrations, without affecting binding affinity. In contrast, when the same manipulation is performed on senescent (24-25 months) rats, negligible change in receptor concentration occurs. These results suggest that age-related increases in estrogen-stimulated prolactin release are not due to decreased dopaminergic inhibition at the receptor level.
authors: Molecular Physiology and Genetics Section, Francis Scott Key Medical Center, Baltimore, Maryland 21224.
authors: K
authors: K
authors: Kochman
authors: J A
authors: JA
authors: Joseph
authors: M R
authors: MR
authors: Blackman
authors: C A
authors: CA
authors: Stagg
authors: G S
authors: GS
authors: Roth
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D015536:Down-Regulation / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D010052:Ovariectomy; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*
chemical_list: D011954:Receptors, Dopamine; D004958:Estradiol; D011388:Prolactin