Synthesis of 2-hydroxyacetyl-7-acetyl-xanthone, a new xanthone derivative endowed with antianaphylactic, analgesic, and antiinflammatory activities.
2-Hydroxyacetyl-7-acetylxanthone (V), a new xanthone derivative, was synthesized in four steps starting from xanthene, by two synthetic approaches. The new compound displayed antianaphylactic activity in the PCA test and in the anaphylaxis shock test in rats. It also displayed analgesic activity in the writhing test in mice, and antiinflammatory activity in the carrageenin edema test in rats. The activity of the new compound has been tentatively interpreted on the basis of its chemical and structural analogy with known drugs.
Bianco
A
A
Dipartimento di Chimica, Università La Sapienza, Roma.
Passacantilli
P
P
Righi
G
G
Brufani
M
M
Cellai
L
L
Marchi
E
E
Milani
M R
MR
D000707:Anaphylaxis / Q000188:drug therapy* / Q000517:prevention & control; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D001993:Bronchodilator Agents; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014966:Xanthenes / Q000138:chemical synthesis* / Q000494:pharmacology; D044004:Xanthones
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001993:Bronchodilator Agents; D014966:Xanthenes; D044004:Xanthones; C061672:2-hydroxyacetyl-7-acetyl-xanthone