[An experimental observation on the calmative and antiepileptic effects of a new synthetic drug SC1001-aminum intupaias].
In this experiment, the calmative and anti-epileptic effects of SC1001A were observed in fifty-five tupaias (Tupaia belangeri Yunalis), both male and female, were divided into four groups. The animals of the first group were perfused with SC1001A (400mg/kg) into their stomach. The animals of the second group were injected with coriaria lactone (5mg/kg, i.m.) for inducing seizures. The remaining two groups received SC1001A 100 and 400 mg/kg respectively by the same way as that of the first group, and 1 min later, they were injected immediately with coriaria lactone (5 mg/kg, i.m.). After the drug being perfused, the behaviors of all the experimental animals were observed continuously for 2-3 h. The results of the experiment indicated that SC1001A was possessed of a calmative effect which appeared shortly after drug (mean 12.88 min) and did not sustain a long time (mean 98 min). In addition, SC1001A was obviously effective on epilepsy induced by coriaria lactone in tupaias, in reducing the seizure rate, the times of petit mal and grand mal, as well as the duration of grand mal.
Chai
H X
HX
Xie
Y G
YG
Chen
Q X
QX
Huang
Y
Y
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002934:Cinnamates / Q000627:therapeutic use*; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D007783:Lactones; D008297:Male; D014417:Tupaia
D000927:Anticonvulsants; D002934:Cinnamates; D007783:Lactones; C058003:SC 1001A; C049836:coriaria lactone