title: Neuroanatomical correlates of a lactate-induced anxiety attack.
abstract: Positron emission tomographic measurements of regional blood flow were used to assess local neuronal activity in patients with panic disorder and in normal control subjects before and during the infusion of sodium lactate. A new technique for the analysis of positron emission tomographic data was employed to identify significant changes in regional blood flow associated with lactate infusion in the panicking patients, nonpanicking patients, and controls. Lactate-induced panic was associated with significant blood flow increases bilaterally in the temporal poles; bilaterally in insular cortex, claustrum, or lateral putamen; bilaterally in or near the superior colliculus; and in or near the left anterior cerebellar vermis. Lactate infusion was not associated with significant changes in regional blood flow in the nonpanicking patients or control subjects. Thus, the identified regions seemed to be involved in an anxiety attack.
authors: Department of Psychiatry, Mallinckrodt Institute of Radiology, St. Louis, MO 63110.
authors: E M
authors: EM
authors: Reiman
authors: M E
authors: ME
authors: Raichle
authors: E
authors: E
authors: Robins
authors: M A
authors: MA
authors: Mintun
authors: M J
authors: MJ
authors: Fusselman
authors: P T
authors: PT
authors: Fox
authors: J L
authors: JL
authors: Price
authors: K A
authors: KA
authors: Hackman
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D001479:Basal Ganglia / Q000098:blood supply; D001921:Brain / Q000000981:diagnostic imaging; D002540:Cerebral Cortex / Q000098:blood supply; D002560:Cerebrovascular Circulation; D005239:Fear; D005260:Female; D006801:Humans; D007773:Lactates; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D010200:Panic; D011699:Putamen / Q000098:blood supply; D013702:Temporal Lobe / Q000098:blood supply; D014055:Tomography, Emission-Computed / Q000379:methods
chemical_list: D007773:Lactates; D019344:Lactic Acid