[Structural and cytochemical changes in cerebral cortical neurons of the offspring of neurosensitized female rats after prenatal administration of thymalin].
Age-related features of structural and cytochemical changes in the brain cortical neurons were investigated in offspring of rats which were neurosensitized and received a course of timalin treatment during gestation. Course treatment with the drug prevented the development of dystrophic changes in cortical neurons, their death and decrease in cell density within the cortical layers. Timalin acted positive in terms of increase in protein content of the cellular nucleus and especially in the cytoplasm. These effects were more pronounced in aged animals. Possible mechanism of timalin action in neurosensitized mothers is discussed.
Kazakova
P B
PB
Konokotina
G F
GF
D000276:Adjuvants, Immunologic; D000818:Animals; D001284:Atrophy / Q000209:etiology / Q000517:prevention & control; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology* / Q000517:prevention & control; D001921:Brain / Q000276:immunology*; D002540:Cerebral Cortex / Q000276:immunology / Q000473:pathology*; D005260:Female; D007112:Immunity, Maternally-Acquired; D009474:Neurons / Q000473:pathology*; D011247:Pregnancy; D051381:Rats; D013951:Thymus Hormones / Q000008:administration & dosage*
D000276:Adjuvants, Immunologic; D001323:Autoantibodies; D013951:Thymus Hormones; C032805:thymalin
Strukturnye i tsitokhimicheskie izmeneniia neĭronov kory mozga potomstva neĭrosensibilizirovannykh samok krys pri antenata'lnom vvedenii timalina.