Haemophilus influenzae type b disease in the Oxford region.
A prospective survey of children in the Oxford region identified 200 cases of systemic Haemophilus influenzae type b disease in the first three and a half years of the study. The annual incidence in children less than 5 years of age was 33.4/100,000. This represents a cumulative incidence of one systemic infection in 600 children before their 5th birthday. The mortality was 5.0%. The risk of H influenzae type b meningitis was one in 850 with a mortality of 5.6%, and substantial morbidity among survivors. From the total live birth rate, about 1300 cases of systemic H influenzae type b disease, over 900 cases of H influenzae type b meningitis, and 65 deaths would be predicted annually in children in the United Kingdom.
Tudor-Williams
G
G
University Department of Paediatrics, John Radcliffe Hospital, Oxford.
Frankland
J
J
Isaacs
D
D
Mayon-White
R T
RT
MacFarlane
J A
JA
Slack
M P
MP
Anderson
E
E
Rees
D G
DG
Moxon
E R
ER
D002648:Child; D002675:Child, Preschool; D004739:England; D006192:Haemophilus Infections / Q000453:epidemiology* / Q000401:mortality; D006193:Haemophilus influenzae; D006801:Humans; D007223:Infant; D008583:Meningitis, Haemophilus / Q000453:epidemiology / Q000401:mortality; D011446:Prospective Studies