Urinary excretion of N-acetyl-beta-D-glucosaminidase in normal and complicated pregnancy.
The urinary excretion of N-acetyl-beta-D-glucosaminidase activity, a sensitive indicator of renal tubular injury, was monitored during and after pregnancy. During normal pregnancy, enzymuria increased progressively to levels 3-4 times above normal in the third trimester. In diabetic mothers, enzyme excretion followed a similar pattern, but was generally higher than in uncomplicated pregnancies. Also in preeclampsia, enzymuria tended to be higher than in normal pregnancy. Enzyme excretion normalized about a year after normal pregnancies, but remained elevated in diabetic subjects and in patients who had developed preeclampsia. This latter finding indicates that marginal persistent renal damage may occur during preeclampsia.
Hultberg
B
B
Department of Clinical Chemistry, University of Lund, Sweden.
Isaksson
A
A
Krutzén
E
E
Nilsson-Ehle
P
P
D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D005260:Female; D006801:Humans; D049590:Postpartum Period / Q000652:urine; D011225:Pre-Eclampsia / Q000652:urine*; D011247:Pregnancy / Q000652:urine*; D011254:Pregnancy in Diabetics / Q000652:urine*
D000118:Acetylglucosaminidase