title: Basal lamina enhances hippocampal neurite outgrowth in vitro.
abstract: To investigate the involvement of the extracellular matrix in central neuron neurite outgrowth, dissociated hippocampal neurons were cultured on basal lamina prepared from chick embryo retina. After 2 days in culture, the basal lamina was found to promote marked hippocampal neurite outgrowth. The average neurite length was over twice that on collagen plus laminin-treated coverslips. These results clearly indicate that central neurons as well as peripheral neurons respond to the components of basal lamina and thus extend their processes.
authors: National Institute for Physiological Sciences, Okazaki, Japan.
authors: T
authors: T
authors: Nakayama
authors: H
authors: H
authors: Sugiyama
authors: S
authors: S
authors: Furuya
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000502:physiology*; D002454:Cell Differentiation; D002478:Cells, Cultured; D002642:Chick Embryo; D003712:Dendrites / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology* / Q000502:physiology; D051381:Rats; D012160:Retina / Q000166:cytology