Serum and urinary phosphate during and after prolonged muscular ischaemia in non-exercising men and women.
Serum inorganic phosphate (Pi) concentrations and urinary Pi excretions were measured in nine patients undergoing abdominal aortic bypass grafting (group I) and in nine patients undergoing lower limb arterial embolectomy (group II). In group I, serum Pi concentrations were normal until 24 h after reperfusion, when they decreased, reaching their nadir at 48 h (median Pi 0.45 mmol 1(-1). The urinary phosphate clearance relative to the creatinine clearance (Cp/Cc) increased 5 min after reperfusion reaching a maximal median value (0.454) in the 2-24-h collection period. In group II, eight patients had a normal and one had a subnormal serum Pi before reperfusion. None developed hypo- or hyperphosphataemia and the Cp/Cc remained unchanged. Daily urinary Pi excretion was higher in group I than in group II (P less than 0.03). The authors concluded that the regional muscular ischaemia in non-exercising men and women was not associated with hyperphosphataemia. The possible influence of major surgery and anaesthesia on phosphate homeostasis should be considered.
Andersen
P T
PT
Department of Thoracic and Vascular Surgery, Aalborg Sygehus, Denmark.
Nielsen
L K
LK
Hansen
A K
AK
Toft
E
E
Jensen
B V
BV
D001012:Aorta, Abdominal / Q000601:surgery; D001807:Blood Vessel Prosthesis; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000601:surgery; D007511:Ischemia / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply*; D010710:Phosphates / Q000378:metabolism*; D005082:Physical Exertion
D010710:Phosphates