title: t(3;22)(q27;q11): a novel translocation associated with diffuse non-Hodgkin's lymphoma.
abstract: Of 187 specimens of non-Hodgkin's lymphoma and four hyperplastic lymphoid proliferations with clonal chromosome abnormalities ascertained serially over a 4 1/2-year period, nine cases with t(3;22)(q27;q11) were identified. Seven of the lymphomas were diffuse tumors, predominantly large cell type. The eighth tumor, a follicular small cleaved cell lymphoma, exhibited a t(3;22) and a t(14;18)(q32;q21). The ninth case was a lymph node from a human immunodeficiency virus-positive patient which showed atypical hyperplasia. Overall survival of t(3;22) diffuse lymphoma patients was not different from that of patients with abnormal karyotypes without t(3;22). The t(3;22) diffuse tumors studied showed a disproportionate frequency of lambda light chain on their cell surfaces, a finding similar to that observed in t(8;22)(q24;q11) Burkitt's lymphomas. Our results indicate that the t(3;22)(q27;q11) is the third most common recurring translocation in diffuse non-Hodgkin's lymphoma.
authors: Laboratory of Cancer Genetics and Cytogenetics, Sloan-Kettering Institute, New York, NY.
authors: K
authors: K
authors: Offit
authors: S
authors: S
authors: Jhanwar
authors: S A
authors: SA
authors: Ebrahim
authors: D
authors: D
authors: Filippa
authors: B D
authors: BD
authors: Clarkson
authors: R S
authors: RS
authors: Chaganti
mesh_terms: D000328:Adult; D000368:Aged; D002892:Chromosomes, Human, Pair 22; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic