Anticardiolipin antibody: a marker of immune reactivity.
An enzyme-linked immunosorbent assay for anticardiolipin (ACL) antibody was performed on 250 consecutive antinuclear antibody (ANA) or anticytoplasmic antibody (ACA) positive sera and 50 consecutive ANA/ACA negative sera submitted to a rheumatology reference laboratory for ANA testing. Of the 250 ANA/ACA positive sera, 33 (13%) were found to be ACL antibody positive. This compared with only 2 (4%) ACL antibody positive samples among the 50 ANA/ACA negative controls. Chart review revealed only one documented case of thrombosis in ACL antibody positive patients. We conclude that among ANA/ACA positive patients, ACL antibody is a frequent finding. ACL antibody in the population studied is not associated with thrombosis. ACL antibody in this group appears to more accurately reflect immune reactivity than a thrombotic state.
Hoppmann
R A
RA
Department of Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC.
Loeser
R
R
Saluta
G
G
Rothberger
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000032:analysis*; D000974:Antibodies, Antinuclear / Q000276:immunology; D000917:Antibody Formation; D002308:Cardiolipins / Q000276:immunology*; D002648:Child; D003593:Cytoplasm / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008875:Middle Aged; D013927:Thrombosis / Q000276:immunology
D000906:Antibodies; D000974:Antibodies, Antinuclear; D002308:Cardiolipins; D007074:Immunoglobulin G; D007075:Immunoglobulin M