The effect of slime production on vancomycin efficacy in the treatment of experimental endocarditis due to Staphylococcus epidermidis.
We compared the efficacy of vancomycin in the treatment of experimental endocarditis caused by either a parent strain of Staphylococcus epidermidis that produced slime or a daughter strain that produced less slime. After subcutaneously administered vancomycin, we noted similar cure rates and similar microbiological characteristics of endocardial infections in rats challenged with these strains, regardless of slime produced.
Baddour
L M
LM
Department of Medicine, University of Tennessee, Memphis.
Christensen
G D
GD
Schadow
K H
KH
D000268:Adhesiveness; D000818:Animals; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D008297:Male; D008826:Microbial Sensitivity Tests; D051381:Rats; D011919:Rats, Inbred Strains; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D013212:Staphylococcus epidermidis / Q000187:drug effects; D014640:Vancomycin / Q000627:therapeutic use*
D014640:Vancomycin