Assessment of unscheduled DNA synthesis in Fischer 344 rat pachytene spermatocytes exposed to caprolactam or benzoin in vivo.
Male Fischer 344 rats were treated with the non-carcinogenic chemicals CAP and ZOIN. The spermatogenic cells were isolated at selected times post-exposure for assessment of chemically-induced DNA damage by quantitative autoradiography of unscheduled DNA synthesis (UDS). Neither chemical (750 mg/kg administered by gavage) induced UDS in pachytene spermatocytes isolated 12, 24 or 48 h after treatment.
Working
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PK
Department of Genetic Toxicology, Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709.
D000818:Animals; D001381:Azepines / Q000633:toxicity*; D001573:Benzoin / Q000633:toxicity*; D002209:Caprolactam / Q000633:toxicity*; D004260:DNA Repair / Q000187:drug effects*; D008297:Male; D009153:Mutagens; D051381:Rats; D011916:Rats, Inbred F344; D013090:Spermatocytes / Q000187:drug effects*
D001381:Azepines; D009153:Mutagens; D002209:Caprolactam; D001573:Benzoin