Wegener's granulomatosis (WG) and insulin dependent diabetes mellitus (IDDM).
We report a case of a 14 year-old girl with Wegener's granulomatosis (WG) complicated by its direct brain invasion and insulin dependent diabetes mellitus (IDDM). This case was diagnosed as WG early in its onset and successfully treated. As for IDDM of this case, the presence of HLA-DR4 and the islet cell surface antibody (ICSA) was demonstrated. To our knowledge, this is the first case report on IDDM associated with WG. We consider that WG may precipitate the development of IDDM in a genetically predisposed subject.
Sugimoto
A
A
Third Department of Internal Medicine, Miyazaki Medical College, Japan.
Sugimoto
S
S
Tanaka
M
M
Kuribayashi
T
T
Takemura
J
J
Matsukura
S
S
Sugiyama
S
S
D000293:Adolescent; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000276:immunology; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000473:pathology; D006684:HLA-DR Antigens / Q000032:analysis; D015804:HLA-DR4 Antigen; D006801:Humans
D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen