Release of platelet Met-enkephalin, but not serotonin, in migraine. A platelet response unique to migraine patients?
Plasma-induced release of platelet-serotonin and Met-enkephalin was studied by incubating platelets from migraineurs, tension headache patients and healthy volunteers with water, plasma collected during migraine attacks and with plasma collected during attack-free periods. Migraine-attack plasma, but not migraine attack-free plasma, released Met-enkephalin from platelets of migraineurs. Platelets of healthy controls or tension headache sufferers did not release their Met-enkephalin in response to either incubation medium. In contrast to Met-enkephalin, serotonin was not released from platelets in relevant quantities by migraine-attack plasma.
Ferrari
M D
MD
Department of Neurology, University Hospital, Leiden, The Netherlands.
Odink
J
J
Frölich
M
M
Tapparelli
C
C
Portielje
J E
JE
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood*; D012701:Serotonin / Q000097:blood*
D012701:Serotonin; D004744:Enkephalin, Methionine