Nitroprusside in children after cardiopulmonary bypass: a study of thiocyanate toxicity.
Thiocyanate levels, an indicator of nitroprusside toxicity, were studied in 22 children after repair of structural heart disease during cardiopulmonary bypass. At the total dose (2.6 +/- 2.3 mg/kg) and time (34.4 +/- 19 h) ranges of this study, no evidence of toxicity was detected, despite this total dose exceeding recommended maximum in some patients. Nitroprusside infusion, as described, in children with normal hepatic and renal function is safe and may not warrant routine assessment of thiocyanate levels.
Kunathai
S
S
Adolph Basser Institute of Cardiology, Children's Hospital, Camperdown, Sydney, Australia.
Sholler
G F
GF
Celermajer
J M
JM
O'Halloran
M
M
Cartmill
T B
TB
Nunn
G R
GR
D001219:Aspartate Aminotransferases / Q000097:blood; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D005292:Ferricyanides / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D009599:Nitroprusside / Q000009:adverse effects / Q000627:therapeutic use*; D011182:Postoperative Care; D013861:Thiocyanates / Q000097:blood*; D014508:Urea / Q000097:blood
D005292:Ferricyanides; D013861:Thiocyanates; D009599:Nitroprusside; D014508:Urea; D001219:Aspartate Aminotransferases; C031760:thiocyanate