Open trial of fluoxetine in obsessive-compulsive disorder.
A 12-week open trial of fluoxetine in 61 obsessive-compulsive disorder patients significantly improved depressive and obsessive-compulsive symptoms. Baseline depression scores were not related to improvement on two obsessive-compulsive scales. The results reinforce the hypothesis of serotonergic abnormalities in obsessive-compulsive disorder.
Jenike
M A
MA
Harvard Medical School, OCD Clinic and Research Unit, Massachusetts General Hospital, Boston 02114.
Buttolph
L
L
Baer
L
L
Ricciardi
J
J
Holland
A
A
D000328:Adult; D003863:Depression / Q000188:drug therapy; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy*; D010556:Personality Tests
D005473:Fluoxetine