Effect of early human malnutrition on waking and sleep organization.
In order to evaluate the effect of early human malnutrition (EHM) on waking and sleep organization, a group of 12 infants malnourished (M) from birth were investigated in their first year of life through 24-h polygraphic recordings. The same infants were recorded again after nutritional rehabilitation (R). A group of 12 age-paired normal infants served as controls (C). Both young (less than 4 months) and older (greater than or equal to 4 months) M infants showed a distribution of classes of waking duration different from that of C while the trend with age of the longest sustained waking (LSW) is similar in M and in C infants. The durations distribution of sleep episodes does not differ between M and C infants, while the longest sustained sleep (LSS) is significantly shorter in M than in C infants. The LSW is less clearly located in the day-time and the LSS is less clearly located in the night-time in M infants as compared to C infants. The quiet sleep-paradoxical sleep cycles are significantly shorter in older M infants because of the reduction of quiet sleep. Nutritional rehabilitation tends to improve waking and sleep organization.
Peirano
P
P
INSERM U3, Hôpital de la Salpétrière, Paris, France.
Fagioli
I
I
Singh
B B
BB
Salzarulo
P
P
D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007228:Infant Nutrition Disorders / Q000503:physiopathology* / Q000534:rehabilitation; D007231:Infant, Newborn; D008297:Male; D012890:Sleep / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D014851:Wakefulness / Q000502:physiology*