title: Occupational exposure to solvents and cerebellar, brainstem and vestibular functions.
abstract: Forty-eight persons (age 44, SD 9 years) exposed to paint solvents and 40 nonexposed referents (age 45, SD 9 years) were examined. The duration of exposure was 4 to 30 (mean 20) years and the life-time exposure level was estimated to have been 10 to 330 (mean 60%) of the hygienic standard. The methods used were a neurological examination, electroencephalography, brainstem auditory-evoked potentials, electronystagmography, and posturography. Life-time exposure was estimated on the basis of a detailed occupational history and environmental measurements made at the work places over several years. The average weekly alcohol consumption was established in a detailed interview. Due to the small number of subjects examined, the study was inconclusive. The findings classified as abnormal were slightly more common in the exposed than in the referents, and in the persons who used alcohol than in the non-users. The differences were not statistically significant, and no exposure-response relationships were found.
authors: Institute of Occupational Health, Helsinki, Finland.
authors: M
authors: M
authors: Antti-Poika
authors: M
authors: M
authors: Ojala
authors: E
authors: E
authors: Matikainen
authors: E
authors: E
authors: Vaheri
authors: J
authors: J
authors: Juntunen
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D001933:Brain Stem / Q000187:drug effects; D002531:Cerebellum / Q000187:drug effects; D004569:Electroencephalography; D004584:Electronystagmography; D004781:Environmental Exposure; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010150:Paint; D012997:Solvents / Q000009:adverse effects*; D014722:Vestibule, Labyrinth / Q000187:drug effects
chemical_list: D012997:Solvents