Blastogenic responses of human lymphocytes to a streptococcal preparation OK-432 and its fractions.
This study was undertaken to examine the blastogenic responses of PBL to Streptococcal preparation OK-432 and its fractions. The results showed that OK-432 and its fractions, Su-PR and PM, have the mitogenic activity against human lymphocytes. The demonstration that PBL which had been cultured with OK-432 expressed IL-2 receptors and the blastogenic responses of PBL to OK-432 were inhibited by anti-IL-2 antibody suggested that IL-2 and IL-2 receptors might play a central role in OK-432-induced proliferation of human lymphocytes.
Tanaka
T
T
3rd Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
Kaneko
Y
Y
Haba
F
F
Katsuta
S
S
Tsutsui
K
K
Tamaki
S
S
Chen
D R
DR
Suzuki
S
S
Ueda
R
R
Yamamoto
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001402:B-Lymphocytes / Q000276:immunology; D001688:Biological Products / Q000494:pharmacology*; D006801:Humans; D007167:Immunotherapy; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008875:Middle Aged; D008934:Mitogens; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D010844:Picibanil / Q000302:isolation & purification / Q000494:pharmacology*; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology
D001688:Biological Products; D008934:Mitogens; D015375:Receptors, Interleukin-2; D010844:Picibanil