[Nucleation time and growth time in patients with cholesterol gallstone--factors affecting nucleation time and growth time and effect of UDCA and CDCA].
Nucleation time (NT) and growth time (GT) were measured in gallbladder bile of patients with cholesterol gallstones. NT was significantly shortened (NT less than 10 days) in pure cholesterol stones but was moderately shortened (11 less than or equal to NT less than or equal to 21) in mixed and combination stones. GT also was accelerated (GT less than 7 days) in cholesterol stones. NT was shortened in increased biliary total protein, but on the contrary, was shortened in decreased apo A-I. NT of bile by UDCA therapy but not CDCA was extended. This suggests that increased apo A-I during UDCA therapy might imply extension of NT. The strong negative correlation between GT and CSI of bile suggests that CSI plays an important role in crystal growth.
Nomura
Y
Y
D000368:Aged; D001646:Bile / Q000378:metabolism; D002635:Chenodeoxycholic Acid / Q000627:therapeutic use*; D002769:Cholelithiasis / Q000188:drug therapy* / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D003460:Crystallization; D003840:Deoxycholic Acid / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; D014580:Ursodeoxycholic Acid; D002784:Cholesterol