Evaluation of the complement split product C3dg in synovial fluid as a possible diagnostic guide in inflammatory arthropathies.
Analyses of C3 split products with C3d specificity (C3dg) were performed in 157 synovial fluids (SF) of 129 patients with various known joint diseases. Considerable overlap between all inflammatory infectious, and crystal induced disease categories confines the value of such measurements as a diagnostic guide to only a few clinical situations. In seronegative as well as in seropositive rheumatoid arthritis no correlation between SF C3d levels and erythrocyte sedimentation rate could be found.
Michel
B A
BA
Department of Rheumatology, University Hospital, Zurich, Switzerland.
Schlumpf
U
U
Simmler
F
F
D001168:Arthritis / Q000175:diagnosis / Q000276:immunology*; D001170:Arthritis, Infectious / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology; D003167:Complement Activation; D003179:Complement C3b / Q000378:metabolism*; D006801:Humans; D010003:Osteoarthritis / Q000276:immunology; D010446:Peptide Fragments / Q000378:metabolism*; D013582:Synovial Fluid / Q000276:immunology*
D010446:Peptide Fragments; C045477:complement C3d,g; D003179:Complement C3b