Gastrointestinal transit of a solid indigestible capsule as measured by radiotelemetry and dual gamma scintigraphy.
The objectives of the present study were to evaluate gastric and small bowel transit times of an indigestible solid matrix and to characterize the specific changes in intraluminal pH as a function of transit time through the gastrointestinal tract. Particular attention was paid to the lag time at the ileocecal junction. A Heidelberg capsule (HC), labeled with 10 microCi Indium-111, was given orally to six healthy male subjects 15 min after oral ingestion of 100 microCi of 99mTc-sulfur colloid as a liquid fatty meal (4 ml/kg). Intraluminal pH was monitored continuously via the HC. Gastric and small bowel transit of the radionuclides was monitored via external scintigraphy at 0.5-hr intervals. Gastric residence times (GRT) of the HC ranged from 2.8 to 4.8 hr. with a mean (+/- SD) of 3.6 +/- 0.8 hr. These values were independent of the individual's weight, height, or body surface area. Small bowel transit times of the HC ranged from 2.8 to greater than 5.5 hr. which were consistent with the reported values of 3 to 5 hr. The lag times of the HC at ileocecal junction ranged from 0.8 to greater than 2.5 hr. The presence of the lag times at the ileocecal junction in all subjects confirmed that it acts as a valve or sphincter. Mouth-to-cecum transit times of the HC occurred within 9.0 hr in 50% of the subjects. In general, following a sharp rise upon pyloric passage of HC the pH dropped slightly but then increased linearly throughout the small intestine.(ABSTRACT TRUNCATED AT 250 WORDS)
Mojaverian
P
P
Division of Clinical Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Chan
K
K
Desai
A
A
John
V
V
D000328:Adult; D002214:Capsules; D002432:Cecum / Q000000981:diagnostic imaging / Q000502:physiology; D005069:Evaluation Studies as Topic; D005772:Gastrointestinal Transit; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007080:Ileocecal Valve / Q000502:physiology; D007082:Ileum / Q000000981:diagnostic imaging / Q000502:physiology; D008297:Male; D011877:Radionuclide Imaging / Q000379:methods; D013686:Telemetry / Q000379:methods
D002214:Capsules