Klebsiella bacteremia. A 10-year review in a cancer institution.
A total of 368 episodes of Klebsiella bacteremia occurred in 330 cancer patients, representing a rate of four episodes per 1000 hospital admissions. Eighty-eight percent of these infections were acquired nosocomically and 58% of the patients received antibiotics during the preceding 10-day period. There was pulmonary infection in 24% of the patients, shock in 25%, and disseminated intravascular coagulation in 7%. The overall response rate was 69%. Response rates were significantly lower among patients with shock (25% versus 83%), hemorrhage (29% versus 76%), and pneumonia (37% versus 79%). The combination of a cephalosporin plus an aminoglycoside produced the highest response rate (79%). Klebsiella sp continue to be an important cause of infection in patients with cancer.
Bodey
G P
GP
Department of Medical Specialties, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Elting
L S
LS
Rodriquez
S
S
Hernandez
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002173:Cancer Care Facilities; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D005334:Fever; D006782:Hospitals, Special; D006801:Humans; D007223:Infant; D007710:Klebsiella Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018805:Sepsis / Q000188:drug therapy / Q000453:epidemiology*; D015163:Superinfection / Q000453:epidemiology
D000900:Anti-Bacterial Agents