Chiasma-based models of multilocus recombination: increased power for exclusion mapping and gene ordering.
Cytological evidence indicates that the number of chiasmata which can occur on any given chromosome arm is limited. In this paper a Monte-Carlo simulation study is used to compare the power of a model of multilocus recombination parameterized in terms of chromosome-specific chiasma distributions with the traditional model parameterized by recombination fractions in adjacent intervals. Two specific gene mapping problems are considered: excluding a test locus from a given chromosome map and ordering a test locus with respect to a fixed map of syntenic marker loci. We show that the chiasma-based models require significantly fewer observations to exclude or order a test locus and that they are quite robust to errors in specifying the underlying true chiasma distribution.
Goldgar
D E
DE
Department of Medical Informatics, University of Utah, Salt Lake City 84108.
Fain
P R
PR
Kimberling
W J
WJ
D000818:Animals; D002874:Chromosome Mapping; D003434:Crossing Over, Genetic; D004330:Drosophila / Q000235:genetics; D005819:Genetic Markers; D008957:Models, Genetic; D009010:Monte Carlo Method; D011995:Recombination, Genetic; D014960:X Chromosome
D005819:Genetic Markers