[Correlations between the endothelium-dependent relaxation of the aorta and arterial pressure in rats with myocardial infarction].
The effect of experimental myocardial infarction on endothelium-dependent relaxation was studied on isolated rat aorta and compared with the dynamics of arterial pressure (AP). It was shown that the endothelium-dependent relaxation of aorta was increased 1.8 times 3 h following the myocardial infarction. Simultaneously the drop in AP which had begun immediately following the experimental infarction became maximal. In 24 h both the indices were restored practically to the initial level. There was a significant negative correlation between the extent of endothelium-dependent relaxation and AP. It was suggested that the increase in endothelium-dependent relaxation could influence vascular tone, the drop in AP, and, finally, the development of cardiogenic shock in myocardial infarction in man.
Meerson
F Z
FZ
Manukhina
E B
EB
Lapshin
A V
AV
Ustinova
E E
EE
D000818:Animals; D001011:Aorta / Q000503:physiopathology*; D001794:Blood Pressure; D004730:Endothelium, Vascular / Q000503:physiopathology*; D008297:Male; D009203:Myocardial Infarction / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012770:Shock, Cardiogenic / Q000209:etiology; D013997:Time Factors
Sootnoshenie éndoteliĭzavisimogo rasslableniia aorty i arterial'nogodavleniia krysy pri infarkte miokarda.