Energy-dispersive x-ray microscopy to trace gadolinium in tissues.
An electron microscopic technique, energy-dispersive x-ray (EDX) analysis, was applied to rat tissue specimens containing gadolinium diethylenetriamine-pentaacetic acid (DTPA). EDX spectroscopy was able to detect the characteristic radiation spectra of gadolinium from tissues in concentrations as low as 0.005 mmol per gram of tissue. A mapping algorithm allowed the detected spectra to be assigned to a specific site of origin within the tissue. This technique allows direct visualization of the location of Gd-DTPA complexes in tissues.
Elster
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AD
Department of Radiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
D000818:Animals; D001923:Brain Chemistry; D004577:Electron Probe Microanalysis / Q000295:instrumentation / Q000379:methods; D019786:Gadolinium DTPA; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D004369:Pentetic Acid / Q000493:pharmacokinetics*; D051381:Rats; D014018:Tissue Distribution
D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA