Posttraumatic narcolepsy: the complete syndrome with tissue typing. Case report.
Although sleep disturbances following head injury are common, well-documented posttraumatic narcolepsy has rarely been reported. A patient with all four major features of narcolepsy following significant head injury is presented. Tissue typing revealed the presence of the human lymphocyte antigen DR2, which is strongly associated with idiopathic narcolepsy. Interaction between the brain injury and a genetic predisposition appears to be involved in the development of posttraumatic narcolepsy.
Good
J L
JL
Department of Neurology, University of Maryland School of Medicine, Baltimore.
Barry
E
E
Fishman
P S
PS
D000328:Adult; D001930:Brain Injuries / Q000150:complications* / Q000276:immunology; D006681:HLA-D Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D009290:Narcolepsy / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology
D006681:HLA-D Antigens