[The evaluation of the therapeutic effect on acute myocardial infarction by radioisotope method--assessment of the intravenous injection of urokinase and comparison with the results of PTCR + PTCA].
The therapeutic effect of intravenous injection of Urokinase (UK method) on acute myocardial infarction (AMI) was studied and compared with the results of the therapeutic effect of PTCR + PTCA. The subjects comprise 108 cases with AMI, and a radioisotope examination was performed in the acute stage to calculate LVEF and Tl-defect ratio (Tl-DR). Measured by the UK method, Tl-DR in the group given 1.2 X 10(6) units of UK was 1.63 +/- 0.8, which was lower than the 2.4 +/- 1.33 for the group given 9.6 X 10(5) unit of UK, whereas a favorable therapeutic effect was obtained in both groups compared to 3.5 +/- 2.5 in the control group. In the group given UK within 6 hours after the onset of AMI, favorable results were obtained for LVEF (44.5 +/- 11.2%) and Tl-DR (1.68 +/- 0.82). The UK group showed as better results as the PTCR + PTCA group for LVEF (42.3 +/- 11.3 vs. 38.1 +/- 7.4) and Tl-DR (2.10 +/- 1.19 vs. 2.09 +/- 0.62). In both the UK and PTCR + PTCA groups, Tl-DR was well maintained despite an increase in the peak CPK and a decrease in LVEF, and, therefore, the conservation of stunned myocardium in the acute stage was suggested. From the above, it was concluded that the UK method is useful for treating AMI.
Yamazaki
J
J
Kawamura
Y
Y
Okuzumi
I
I
Morishita
T
T
Ohsawa
H
H
Yabe
Y
Y
Saito
T
T
Kamishima
G
G
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000628:therapy*; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
D013794:Thallium Radioisotopes; D014568:Urokinase-Type Plasminogen Activator