title: Osteosarcoma with prominent epithelioid features.
abstract: Osteosarcoma in the metaphysis to epiphysis of the left femur of a 17-year-old male is reported. The lesion appeared osteolytic with sclerotic foci on roentgenographs, accompanied by an extensive tumor shadow in the surrounding soft tissue. While 60% of the tumor was necrotic, histological examination of the remaining viable tissue revealed that it consisted almost entirely of a sheet of epithelioid cells, separated by thin, fibrovascular septa with an alveolar-like pattern, suggestive of metastatic carcinoma. Only a few areas were characterized by malignant osteoid tissue intermingled with the above cells, showing significant positivity for bone-specific alkaline phosphatase and 5'-nucleotidase, thus permitting a diagnosis of osteosarcoma. Autopsy findings revealed that the metastatic foci were histologically similar to those of the primary tumor. Electron microscopy revealed poor development of cytoplasmic organelles, supporting possible derivation from an osteoblastic cell lineage at an early stage.
authors: Department of Pathology, Tottori University School of Medicine, Yonago, Japan.
authors: H
authors: H
authors: Yoshida
authors: T
authors: T
authors: Yumoto
authors: H
authors: H
authors: Adachi
authors: T
authors: T
authors: Minamizaki
authors: N
authors: N
authors: Maeda
authors: K
authors: K
authors: Furuse
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000293:Adolescent; D000469:Alkaline Phosphatase / Q000032:analysis; D001859:Bone Neoplasms / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D002277:Carcinoma / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D004848:Epithelium / Q000473:pathology; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D011379:Prognosis
chemical_list: D000469:Alkaline Phosphatase; D000135:Acid Phosphatase