A general model for the transmembrane proteins of HIV and other retroviruses.
A hypothetical model of the transmembrane (TM) protein of human immunodeficiency virus (HIV) is proposed that is derived from the known structure of the influenza TM protein HA2. This model is consistent with computer algorithms of predicted protein structure and with known properties of TM proteins determined by sequence homology, site-directed mutations, peptide analogs, immunochemistry, or other biologic means. It is applicable to a wide variety of retroviral TM proteins differing widely in overall molecular weight.
Gallaher
W R
WR
Department of Microbiology, Immunology and Parasitology, Louisiana State University Medical Center, New Orleans 70112.
Ball
J M
JM
Garry
R F
RF
Griffin
M C
MC
Montelaro
R C
RC
D000465:Algorithms; D003198:Computer Simulation; D015488:HIV Antigens; D015700:HIV Envelope Protein gp41; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral; D008961:Models, Structural; D011487:Protein Conformation; D012191:Retroviridae Proteins; D014759:Viral Envelope Proteins
D015488:HIV Antigens; D015700:HIV Envelope Protein gp41; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral; D012191:Retroviridae Proteins; D014759:Viral Envelope Proteins