Autocorrelation spectroscopy for particle sizing and stability tests of radiolabelled colloids.
In many nuclear medicine applications a well defined particle size and stability of administered colloids is of great importance. A fast and reliable sizing technique for routine quality control is therefore essential. This paper evaluates autocorrelation spectroscopy with an instrument capable of analysing several peaks simultaneously. A total of nine 99mTc-labelled colloids and one 99Y-labelled colloid were studied. The autocorrelation spectroscopy measurements were compared with the standard sizing technique of microfiltration. A good agreement between the sizing techniques was found for most of the colloids. The reproducibility of successive measurements was within +/- 12% and +/- 40% when using unimodal analysis and SDP analysis, respectively. Autocorrelation spectroscopy was found to be well suited for particle sizing and stability tests of radiolabelled colloids.
Bergqvist
L
L
Department of Radiation Physics, University of Lund, Sweden.
Strand
S E
SE
D003102:Colloids / Q000592:standards*; D004355:Drug Stability; D006801:Humans; D008722:Methods; D009683:Nuclear Medicine / Q000592:standards*; D010316:Particle Size; D011786:Quality Control
D003102:Colloids