[Study of the immunogenicity of conjugates, obtained by means of chemical interaction of benzidine with synthetic polyelectrolytes].
The formation of specific antibodies to benzidine under immunization of rabbits with conjugates obtained by joining benzidine through diazolinkage to vinylpyrrolidone therpolymer (VP) is shown possible. Data obtained demonstrate that blood serum of intact rabbits is able to participate in immunodiffusion reaction with copolymers and therpolymer VP making 1-2 precipitation lines. However, this ability is lost after benzidine linkage, which indicates the possible loss of immunological specificity by macromolecules after interaction between carcinogens and their determinant groups.
Korosteleva
T A
TA
Belokhvostova
A T
AT
Panarin
E F
EF
Nazarova
O V
OV
Solovskiĭ
M V
MV
Potapenkova
L S
LS
D000818:Animals; D001560:Benzidines; D004573:Electrolytes; D000922:Immunotoxins / Q000276:immunology*; D011233:Precipitin Tests; D011760:Pyrrolidinones; D011817:Rabbits
D001560:Benzidines; D004573:Electrolytes; D000922:Immunotoxins; D011760:Pyrrolidinones; C042670:N-vinyl-2-pyrrolidinone
Issledovanie immunogennosti kon''iugatov, poluchennykh putem khimicheskogo vzaimodeĭstviia benzidina s sinteticheskimi poliélektrolitami.