Erdosteine protection from cigarette smoke-induced loss of alpha 1-antitrypsin activity in rat lungs.
Acute inhalation of cigarette smoke induced alpha 1-antitrypsin inactivation in rat lungs. The elastase inhibitory capacity of the protein could be prevented by oral treatment with erdosteine (a mucoregulator endowed with free radical scavenging properties). A partial dose-dependent protection was observed with 500 and 1,000 mg/kg. The mechanism of its action might be related either to the inhibition of alpha 1-antitrypsin oxidation manifested by two SH groups liberated in vivo or to the anti-inflammatory and mucoregulator properties present in the substance.
Biagi
G L
GL
Institute of Pharmacology, Faculty of Medicine, University of Bologna, Italy.
Fregnan
G B
GB
Gazzani
G
G
Vandoni
G
G
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012907:Smoking / Q000378:metabolism*; D013864:Thioglycolates / Q000494:pharmacology; D013876:Thiophenes / Q000494:pharmacology; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
D013864:Thioglycolates; D013876:Thiophenes; D000515:alpha 1-Antitrypsin; C048498:erdosteine