[The role of the leukocytes in the blood-vasal regulation of the blood circulation].
The ability of N-formyl-methionyl-leucyl-phenylalanine-activated leukocytes to influence platelets and vessels was studied. It is shown, that of activation of leukocytes causes a vasoconstriction. The de-endothelialization of the vessels increased this effect. In addition, activated leukocytes increased the platelet aggregation. It was concluded, that activation of leukocytes can trigger thrombogenesis, angiospasm, microembolic syndrome and other disturbances of blood circulation.
Gabrielian
E S
ES
Akopov
S E
SE
Grigorian
M R
MR
D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000502:physiology*; D001775:Blood Circulation / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D002415:Cats; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010477:Perfusion / Q000379:methods; D010974:Platelet Aggregation / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
D009240:N-Formylmethionine Leucyl-Phenylalanine
Rol' leĭkotsitov v gemato-vazal'noĭ reguliatsii krovoobrashcheniia.