[Effect of thymalin on the immunological indices and morphofunctional structure of the uterus in guinea pigs with endometrial hyperplasia].
The efficiency of usage of the preparations of thymalin in hyperplasia of endometrium has been studied in the experiment on 125 female guinea pigs. Indicated pathology was caused by the introduction of oil solution of synestrol during 19 weeks. It is determined that marked hyperplasia of endometrium is developing as a result of prolonged introduction of synestrol in experimental animals and the decrease of the amount of T- and B-lymphocytes takes place. The use of thymalin results in normalization of indexes of immune system and in partial normalization of morphologic structure of endometrium.
Zaporozhan
V N
VN
Khait
O V
OV
Li
L N
LN
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D004028:Dienestrol; D004353:Drug Evaluation, Preclinical; D004714:Endometrial Hyperplasia / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006168:Guinea Pigs; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013951:Thymus Hormones / Q000627:therapeutic use*; D013997:Time Factors; D014599:Uterus / Q000187:drug effects* / Q000276:immunology / Q000503:physiopathology
D000276:Adjuvants, Immunologic; D013951:Thymus Hormones; C032805:thymalin; D004028:Dienestrol
Vliianie timalina na nekotorye immunologicheskie pokazateli i morfofunktsional'nuiu strukturu matki u morskikh svinok s giperplazieĭ éndometriia.