[The role of interleukin-2 in the impaired lymphocyte function after open heart surgery].
To reveal the mechanism of impaired lymphocyte function shown as the suppression of mitogenic proliferation of lymphocytes after open heart surgery, we evaluated the kinetics of Interleukin 2 (IL-2) production and response of lymphocytes sequentially until 7th day postoperatively in 10 patients. Membrane oxygenators were used exclusively and steroids were not administered during this study. In addition to the assay of mitogenic response (PHA), we measured IL-2 production and response utilizing IL-2 dependent cytotoxic T cell line and mitogenic proliferation to standard IL-2 respectively concomitant with plasma cortisol level. The results are as follows. 1. Mitogenic proliferation was suppressed with significance postoperatively (1POD: p less than 0.01). 2. IL-2 production was suppressed with significance postoperatively (3POD: p less than 0.05). In contrast no significant fluctuation of IL-2 responsiveness was observed postoperatively. 3. No correlation between plasma cortisol levels and these impairment was shown in this study. In conclusion impaired IL-2 production might be responsible for deficient lymphocyte function after open heart surgery.
Ide
H
H
Kakiuchi
T
T
Ino
T
T
Hasegawa
T
T
Furuta
N
N
Matsumoto
H
H
Furuse
A
A
D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000502:physiology*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged
D007376:Interleukin-2