Precursor T-cell lymphoma associated with human immunodeficiency virus type 1 (HIV-1) infection. First reported case.
The majority of lymphomas that develop in human immunodeficiency virus type 1 (HIV-1) positive patients have a B-cell phenotype, with few reported cases of T-cell lymphoma. Within the latter group, those that have been comprehensively phenotyped had a mature helper T-cell phenotype (CD4+). We report, for the first time, an HIV-1 positive patient with a precursor T-cell lymphoma (CD7+,CD1-,CD3-,CD4-, and CD8-). T-cell receptor beta and gamma genes were in the germline configuration and integration of HIV-1 DNA could not be detected in the lymphoma cell genome.
Ruff
P
P
Department of Medicine, Hillbrow Hospital, Johannesburg, South Africa.
Bagg
A
A
Papadopoulos
K
K
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D004279:DNA, Viral; D015497:HIV-1; D006801:Humans; D008223:Lymphoma / Q000209:etiology* / Q000235:genetics; D008297:Male; D010641:Phenotype; D011948:Receptors, Antigen, T-Cell / Q000032:analysis; D013601:T-Lymphocytes
D000945:Antigens, Differentiation, T-Lymphocyte; D004279:DNA, Viral; D011948:Receptors, Antigen, T-Cell