Some measures of lipid metabolism in young sterile males before and after testosterone treatment.
The concentration of total cholesterol and triacylglycerols in plasma and their distribution in lipoproteins as well as the level of apolipoprotein-B and of endogenous testosterone were measured in 30 young sterile males before and after the treatment with methyltestosterone (Agovirin SPOFA) in a dose of 10 mg daily for 30 days. Before the treatment the level of total cholesterol in plasma and in VLDL fraction was normal, while that in LDL fraction was increased and in HDL fraction decreased. Similarly, the level of triacylglycerols in plasma was increased and correspondingly also the levels of that in all lipoprotein fractions. After the treatment no changes in total and VLDL cholesterol were found, while a significant decrease in LDL fraction and increase in HDL fraction was observed. Moreover, a significant decrease was found in a level of total plasma and VLDL triacylglycerols.
Hromadová
M
M
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Briatislava.
Hácik
T
T
Malatinský
E
E
Sklovský
A
A
Cervenakov
I
I
D000328:Adult; D001055:Apolipoproteins B / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D008297:Male; D008777:Methyltestosterone / Q000494:pharmacology*; D013739:Testosterone / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism*
D001055:Apolipoproteins B; D014280:Triglycerides; D013739:Testosterone; D002784:Cholesterol; D008777:Methyltestosterone