Evidence for etiologic heterogeneity in Alzheimer's disease.
We briefly describe the evidence for etiologic heterogeneity in Alzheimer's disease. Several different genetic and environmental factors may act separately or in combination to produce the AD phenotype. This potential heterogeneity presents special challenges to those attempting to identify specific genetic influences in the pathogenesis of AD.
Bird
T D
TD
University of Washington School of Medicine, Alzheimer's Disease Research Center.
Schellenberg
G D
GD
Wijsman
E M
EM
Martin
G M
GM
D000544:Alzheimer Disease / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics; D001930:Brain Injuries / Q000150:complications*; D002891:Chromosomes, Human, Pair 21; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans
D004785:Environmental Pollutants