The INT1 oncogene is not rearranged or amplified in lipomas with structural chromosomal abnormalities of 12q13-15.
DNA from nine different solitary subcutaneous lipomas, all with clonal abnormalities affecting the chromosome segment 12q13-15, was examined for rearrangement or amplification of a human INT1 gene sequence. INT1 is a putative oncogene that has been localized to the chromosome band 12q13. No rearrangement or amplification could be detected.
Arheden
K
K
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Mandahl
N
N
Heim
S
S
Mitelman
F
F
D002881:Chromosomes, Human, Pair 12; D004247:DNA / Q000235:genetics; D005784:Gene Amplification; D015321:Gene Rearrangement; D006801:Humans; D008067:Lipoma / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D015183:Restriction Mapping
D004247:DNA