[Hypothalamic phospholipid liposomes in the treatment of the climacteric syndrome].
Phospholipid liposomes have a dopaminergic effect on the human brain. Changes in prolactin and growth hormone secretion have been observed in humans given phospholipid liposomes. The authors have investigated the therapeutic efficacy of hypothalamic phospholipids in the menopausal syndrome. The study was an open trial on 37 outpatients treated with 1 and 2 ampoules i.m. of a preparation of phospholipids (in the form of unilamellar liposomes) for a period of six months. The therapeutic effects were assessed by means of the Hamilton rating scale, MMPI (Minnesota multiphasic inventory test), and a list of psychosomatic symptoms (LSP). In the patients no change in FSH, LH, PRL, or E2 secretion was observed, whereas the neurotic symptomatology appeared remarkably reduced.
Jasonni
V M
VM
Palareti
A
A
Bulletti
C
C
Fuschini
G
G
Naldi
S
S
Ricciardelli
E
E
D000328:Adult; D002979:Climacteric / Q000187:drug effects* / Q000502:physiology / Q000523:psychology; D004337:Drug Carriers; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006801:Humans; D008081:Liposomes; D008950:MMPI; D008875:Middle Aged; D010743:Phospholipids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010908:Pituitary Hormones, Anterior / Q000378:metabolism; D011569:Psychiatric Status Rating Scales
D004337:Drug Carriers; D008081:Liposomes; D010743:Phospholipids; D010908:Pituitary Hormones, Anterior; D004958:Estradiol
I liposomi di fosfolipidi ipotalamici nel trattamento della sindrome climaterica.