"On-off"-induced lethal hyperthermia.
Neuroleptic malignant syndrome (NMS) is being increasingly recognized as a potential complication of neuroleptic therapy. Similar hyperthermic episodes have also been described in other settings of abrupt cessation of dopaminergic stimulation such as levodopa withdrawal. We report a fatal NMS-like episode occurring as a complication of an "off" period in a patient with Parkinson's disease.
Pfeiffer
R F
RF
Section of Neurology, University of Nebraska College of Medicine, Omaha.
Sucha
E L
EL
D000978:Antiparkinson Agents / Q000627:therapeutic use; D005334:Fever / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology
D000978:Antiparkinson Agents