title: Vasopressin reduces food intake in goats.
abstract: The effect of arginine vasopressin (VP) on cumulative food intake and meal pattern was tested in pygmy goats. VP injected intraperitoneally (I.P.) (0.75, 1.5 and 3.0 micrograms kg-1 body weight) appeared to reduce food intake in a dose-dependent manner by reducing the size of the first meal and by increasing the first intermeal interval (IMI). The hypophagic effect of VP was reversed by both a V1-receptor antagonist and an alpha-adrenergic antagonist. Exogenous VP (0.75 and 1.5 microgram kg-1 body weight I.P.) produced increases in plasma VP concentration which also may occur in stressful situations. VP might therefore be related to stress-induced anorexia.
authors: Institut für Veterinär-Physiologie, Universität Zürich, Switzerland.
authors: A H
authors: AH
authors: Meyer
authors: W
authors: W
authors: Langhans
authors: E
authors: E
authors: Scharrer
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000037:antagonists & inhibitors / Q000097:blood / Q000494:pharmacology*; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D004326:Drinking; D004435:Eating / Q000187:drug effects*; D005260:Female; D005502:Food; D006041:Goats; D007274:Injections, Intraperitoneal; D011863:Radioimmunoassay; D013997:Time Factors
chemical_list: D001127:Arginine Vasopressin