Human brain and spinal cord scan after intracerebroventricular administration of iodine-123 morphine.
[123I]iodomorphine (IMPH) was administered intracerebroventriculary (i.c.v.) in eight patients treated by i.c.v. morphinotherapy (i.c.v.m.). Scans obtained by gamma-scintigraphy over 1 h post-injection showed only a slight diffusion of IMPH beyond the ventricular system, particular attention being paid to the spinal cord. These data agree well with induced i.c.v.m. analgesia (mean latency 20 min) and biological results such as HPLC assay of morphine in the lumbar cerebrospinal fluid, supporting the action of morphine only on the central opiate receptors.
Tafani
J A
JA
Service Central de Médecine Nucléaire, CHU Purpan, Toulouse, France.
Lazorthes
Y
Y
Danet
B
B
Verdie
J C
JC
Esquerre
J P
JP
Simon
J
J
Guiraud
R
R
D001921:Brain / Q000000981:diagnostic imaging*; D006801:Humans; D007276:Injections, Intraventricular; D007457:Iodine Radioisotopes; D009022:Morphine Derivatives / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D010148:Intractable Pain / Q000188:drug therapy*; D011877:Radionuclide Imaging; D013116:Spinal Cord / Q000000981:diagnostic imaging*
D007457:Iodine Radioisotopes; D009022:Morphine Derivatives; C061704:2-iodomorphine