[Effect of monoamine oxidase inhibitors on the concentrations of free and conjugated dopamine in rat small intestine and liver following exogenous dopamine administration].
In rats treated with MAO inhibitors, free and conjugated catecholamine concentrations in small intestine and liver following exogenous free dopamine (DA) administration at the rate of 2 micrograms.kg-1.min-1 for two hours were measured. Free and conjugated DA concentrations increased in both small intestine and liver following exogenous free DA administration. Free and conjugated DA concentrations of the tissue of the rat treated with MAO inhibitors were higher than that of the control group. These results suggest that transformation of free DA into conjugated DA is activated in the small intestine and liver of the rat treated with MAO inhibitors when exogenous DA is given.
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D000818:Animals; D004298:Dopamine / Q000008:administration & dosage* / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D008996:Monoamine Oxidase Inhibitors; D004298:Dopamine; D009638:Norepinephrine