Disruption of stromal niches by diffusible factors in the conditioned media of leukemic cell-lines and sera of chronic myelogenous leukemia patients.
The bone-marrow microenvironment has a decisive role in maintaining haemopoietic stem cells and regulating their differentiation. In diseases of the haemopoietic system, viz. anaemias and leukemias, the microenvironment has been shown to play a key role. In this paper we show that leukemic cell conditioned medium and sera from CML patients, interact with the in vitro bone-marrow environment and bring about changes which affect the maintenance of normal stem cells.
Shetty
A
A
Cell Biology Division, Tata Memorial Centre, Bombay, India.
Bapna
V K
VK
Rao
S G
SG
D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D002448:Cell Adhesion; D002455:Cell Division; D003114:Colony-Forming Units Assay; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology* / Q000503:physiopathology; D051379:Mice; D013997:Time Factors; D014407:Tumor Cells, Cultured