title: [99mTc-fosfon distribution in the hip joints and femoral arteries in femur head osteochondropathy in children].
abstract: A study was made of 99mTc-fosfon distribution in the hip joint of children in health and Perthes' disease. The drug distribution asymmetry in the hip joints did not exceed +/- 10%. The 1st stage of disease was characterized by the absence of x-ray signs of head necrosis, a decrease in drug accumulation at the upper pole of the head up to 90% and less. The susceptibility of the test was 0.95, specificity--1, accuracy--0.97. A low level of drug accumulation at the upper pole of the head was retained at the 2nd and 3rd stages. At the 4th stage drug accumulation was increased. Changes in the relative level of drug accumulation at the upper pole of the head were correlated with changes in the indices characterizing the first passage of the drug in the femoral artery of the affected limb: a decrease in the volumetric blood flow at the 1st stage and its regeneration to values of the blood flow in the lateral artery at the 4th stage. The susceptibility of the test was 0.95, but its specificity and accuracy were lower. The combination of gamma topography of the hip joints with gamma chronometry of the first passage of the drug in the femoral arteries using the quantitative criteria of distribution asymmetry expanded and improved the potentialities of radionuclide diagnosis of Perthes' disease.
authors: Iu D
authors: IuD
authors: Kovalenko
authors: V G
authors: VG
authors: Kriuchok
authors: G I
authors: GI
authors: Ioda
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000378:metabolism*; D005271:Femur Head Necrosis / Q000378:metabolism*; D006621:Hip Joint / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D007873:Legg-Calve-Perthes Disease / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism*; D008297:Male; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D009943:Organophosphorus Compounds / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds; D012039:Regional Blood Flow; D013667:Technetium / Q000493:pharmacokinetics*; D013997:Time Factors; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
chemical_list: D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; C059491:technetium Tc 99m phosphon; D013667:Technetium
vernacular_title: Raspredelenie 99mTc-fosfona v tazobedrennykh sustavakh i bedrennykh arteriiakh pri osteokhondropatii golovki bedra u deteĭ.