title: Histamine-induced modulation of olfactory receptor neurones in two species of lobster, Panulirus argus and Homarus americanus.
abstract: In two species of lobster, application of the biogenic amine, histamine (HA), to the soma of olfactory receptor cells suppressed both spontaneous and odour-evoked activity, as shown by electrophysiological recording from single cells. The action of HA was graded, reversible, specific to HA, and had a threshold between 0.1 and 1 mumol l-1. HA increased the conductance of the membrane, primarily to chloride ions. The vertebrate HA receptor antagonist, cimetidine, and the nicotinic receptor antagonist, d-tubocurarine, but not other known vertebrate HA receptor antagonists, reversibly blocked the action of HA. These results suggest that a histaminergic mechanism modulates stimulus-response coupling in lobster olfactory receptor cells and potentially implicate a novel HA receptor, pharmacologically similar to the one recently described in the visual system of flies.
authors: Whitney Laboratory, University of Florida, St Augustine 32086.
authors: T A
authors: TA
authors: Bayer
authors: T S
authors: TS
authors: McClintock
authors: U
authors: U
authors: Grünert
authors: B W
authors: BW
authors: Ache
mesh_terms: D000200:Action Potentials; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D005071:Evoked Potentials; D006632:Histamine / Q000494:pharmacology*; D008121:Nephropidae / Q000502:physiology*; D009812:Odorants; D009830:Olfactory Bulb / Q000502:physiology*; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects; D012903:Smell / Q000187:drug effects*; D014403:Tubocurarine / Q000494:pharmacology
chemical_list: D002927:Cimetidine; D006632:Histamine; D014403:Tubocurarine