title: Structural analysis of the alpha-globin gene cluster in two Chinese families with alpha-thalassemias.
abstract: The inheritance of alpha-thalassemia is determined by restriction endonuclease mapping in the members of two Chinese families with history of Hb H disease. One family carries the South East Asia (SEA) deletion in alpha-thalassemia-1 determinant and the nondeletion mutation in alpha-thalassemia-2 determinant. The other family carries the SEA deletion in alpha-thalassemia-1 determinant and the leftward deletion in alpha-thalassemia-2 determinant. Direct analysis of the genetic defects by gene mapping technique is the most reliable method for detecting minor forms of alpha-thalassemia and provides valuable information for genetic conseling in affected families.
authors: J Y
authors: JY
authors: Wang
authors: J C
authors: JC
authors: Liang
authors: H W
authors: HW
authors: Peng
mesh_terms: D044466:Asian People / Q000235:genetics; D002872:Chromosome Deletion; D004247:DNA / Q000032:analysis; D005260:Female; D005914:Globins / Q000235:genetics*; D006801:Humans; D008297:Male; D005810:Multigene Family; D013789:Thalassemia / Q000235:genetics*
chemical_list: D005914:Globins; D004247:DNA