An association between acute retinal necrosis syndrome and HLA-DQw7 and phenotype Bw62, DR4.
Human leukocyte antigen (HLA) typing was performed on 27 white patients with acute retinal necrosis syndrome. Antigens for the HLA-A, -B, -C, -DR and -DQ loci were determined, and frequencies were compared with racially matched controls. There was a statistically significant increase in the frequency of HLA-DQw7 (11 of 20 [55%] of patients vs 294 of 1546 [19%] of controls, P = .0004, relative risk 5.20) that remained significant at the P = .05 level when the P value was multiplied by the number of antigens tested. The HLA phenotype Bw62, DR4 is also more frequent than in normal control populations (4 of 25 [16%] of patients vs 26 of 1023 [2.6%] of controls, relative risk 7.49). These results support an association between the acute retinal necrosis syndrome and certain HLA specificities and suggest a possible immunogenetic predisposition to the syndrome in some patients.
Holland
G N
GN
Jules Stein Eye Institute, Department of Ophthalmology, UCLA School of Medicine.
Cornell
P J
PJ
Park
M S
MS
Barbetti
A
A
Yuge
J
J
Kreiger
A E
AE
Kaplan
H J
HJ
Pepose
J S
JS
Heckenlively
J R
JR
Culbertson
W W
WW
D005260:Female; D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D006683:HLA-DQ Antigens / Q000032:analysis*; D015804:HLA-DR4 Antigen / Q000032:analysis*; D006801:Humans; D008297:Male; D010641:Phenotype; D012016:Reference Values; D015882:Retinal Necrosis Syndrome, Acute / Q000235:genetics / Q000276:immunology*
D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; C044141:HLA-Bw62; D006683:HLA-DQ Antigens; D015804:HLA-DR4 Antigen