[Why is peroperative antibiotic prophylaxis of infectious complications most effective?].
The concentrations of oxacillin, azlocillin, temocillin, amoxycillin, cefoperazone, cefazoline, netilmicin, clindamicin, ofloxacine in serum and coagulum take a parallel course but their content in the coagulum is ten times lower than in serum--with the exception of doxycycline which reached a 40% value of the serum level in the coagulum. From this ensues that most effective are those antibiotics which can be administered in large doses and which have a long half-life. Unfavourable are antibiotics with a narrow therapeutic range and those with a short half-life. Preoperative application of such doses which create sufficiently high and prolonged levels is the optimal method of antibiotic prophylaxis of infectious complications during surgical operations.
Morávek
J
J
Vanĕk
I
I
Modr
Z
Z
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D011292:Premedication
D000900:Anti-Bacterial Agents
Proc je peroperacní antibiotická profylaxe infekcních komplikací nejúcinnĕjsí?