Pyoderma gangrenosum and adrenocortical carcinoma.
Systemic disorders that have been associated with pyoderma gangrenosum include inflammatory bowel disease, rheumatoid arthritis, paraproteinemias, and hematologic malignancies. We report the case of a 55-year-old woman with pyoderma gangrenosum, IgA monoclonal gammopathy, and a cortisol-secreting adrenocortical carcinoma. Review of the literature revealed one previous case of pyoderma gangrenosum associated with a solid tumor; at autopsy, a carcinoid tumor and an adrenocortical adenoma were found. Our patient's rapid improvement after the carcinoma was resected and her subsequent disease-free course suggests that the two conditions were related. This case suggests that evaluation for underlying malignancy should be considered in patients with pyoderma gangrenosum.
Cole
H G
HG
Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905.
Nelson
R L
RL
Peters
M S
MS
D000306:Adrenal Cortex Neoplasms / Q000150:complications* / Q000601:surgery; D000315:Adrenalectomy; D002277:Carcinoma / Q000150:complications* / Q000601:surgery; D005260:Female; D005734:Gangrene / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D011711:Pyoderma / Q000150:complications*