[Pseudomonas aeruginosa infection of the sternum and costal cartilages in cardiosurgery. Therapeutic experience using aztreonam].
Clinical effectiveness of Aztreonam was studied. This new monobactam antimicrobial agent was tasted in the treatment of post-operative infectious complications of cardiac surgical sternal wounds. Ten patients (4 men and 6 women, age range 20 to 68 years) were entered into the study. All had a Pseudomonas aeruginosa infection of sternum or sternum and ribs and all underwent an extensive regional surgery of the infection wound and received a topical and/or IV treatment with Aztreonam. In all cases we obtained a satisfactory result, with complete eradication of the infection. Both local and systemic tolerance to the drug were excellent and no side-effect was registered. Therefore Aztreonam can be considered an active and safe antibiotic for the treatment of sternal and/or costal postsurgical infections by Pseudomonas aeruginosa.
Donegani
E
E
di Summa
M
M
Agaccio
G
G
Comoglio
C
C
De Paulis
R
R
Matani
A
A
D000328:Adult; D000368:Aged; D001398:Aztreonam / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures; D002356:Cartilage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000209:etiology; D013249:Sternum; D013530:Surgical Wound Infection / Q000188:drug therapy*
D001398:Aztreonam
Infezioni da Pseudomonas aeruginosa dello sterno e delle cartilagini costali in cardiochirurgia. Esperienza terapeutica con Aztreonam.