title: [Modification of the pharmacokinetics of ortophen and its analgesic activity by inducers and inhibitors of xenobiotic metabolism enzymes and thiamine diphosphate].
abstract: Phenobarbital administered in a dose of 70 mg/kg intraperitoneally (once a day for 4 days) was shown to accelerate ortophen elimination from blood of rats and to decrease its analgesic activity. Administration of cimetidine (100 mg/kg, intragastrically once a day for 5 days), cobalt chloride (10 mg/kg, subcutaneously twice) and thiamine diphosphate (10 mg/kg, intraperitoneally once a day for a week) was found to slow down elimination of ortophen from blood and to enhance its analgesic effect. Cimetidine slows down ortophen elimination from blood of the patients.
authors: A A
authors: AA
authors: Pentiuk
authors: N A
authors: NA
authors: Stanislavchuk
authors: B A
authors: BA
authors: Borisenko
mesh_terms: D000700:Analgesics / Q000493:pharmacokinetics* / Q000494:pharmacology; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004008:Diclofenac / Q000493:pharmacokinetics* / Q000494:pharmacology; D004790:Enzyme Induction; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013835:Thiamine Pyrophosphate / Q000494:pharmacology*; D015262:Xenobiotics / Q000378:metabolism*
chemical_list: D000700:Analgesics; D065607:Cytochrome P-450 Enzyme Inhibitors; D015262:Xenobiotics; D004008:Diclofenac; D002927:Cimetidine; D003577:Cytochrome P-450 Enzyme System; D013835:Thiamine Pyrophosphate; D010634:Phenobarbital
vernacular_title: Modifikatsiia farmakokinetiki ortofena i ego anal'geticheskoĭ aktivnosti induktorami i ingibitorami aktivnosti fermentov metabolizma ksenobiotikov i tiamindifosfatom.