Primary carcinoma of the gallbladder. Adjuvant postoperative external irradiation.
Seven patients received the same postoperative (Postop) external-beam irradiation (NRT) after apparent complete removal of gallbladder carcinoma between August 1983 to February 1988. A dosage of 4600 cGy were delivered on a first volume (average treated volume 0.87 liters) corresponding to this of potentially locoregional disease, completed by a boost dose of 900 cGy on the gallbladder bed. Moderate acute side effects were seen in five patients; regressive dyspepsia in three and mean weight loss of 1.5 kg in three. The minimum follow-up is 5 months and the maximum is 58 months. Five patients are alive with no evidence of disease (NED) after 5, 9, 11, 31, and 58 months, respectively. One died at 12 months with local recurrence, liver metastasis, and peritoneal implants. Another one died at 26 months of abdominal recurrence. With regard to the natural history of this tumor, the dismal results obtained by surgery alone, and our preliminary data, we advocate Postop adjuvant XRT as a safe treatment.
Bosset
J F
JF
Department of Radiation Oncology, Centre Hospitalier Universitaire, Besançon, France.
Mantion
G
G
Gillet
M
M
Pelissier
E
E
Boulenger
M
M
Maingon
P
P
Corbion
O
O
Schraub
S
S
D000368:Aged; D001835:Body Weight / Q000528:radiation effects; D002763:Cholecystectomy; D003131:Combined Modality Therapy; D004415:Dyspepsia / Q000209:etiology; D005260:Female; D005706:Gallbladder Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D011182:Postoperative Care; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects