[Erythropoietin activity in plasma after amantinine poisoning and hypoxia].
Determination of plasma erythropoietin activity was performed on highly sensitive to exogenous erythropoietin recipients-posthypoxic polycytemic mice. After submitting male white rats to a two-hour hypobaric hypoxia (0.42 atm.) we obtained an increase in the plasma erythropoietic activity with 367% in comparison with control animals. Amanitin effect inhibited hypoxic stimulated plasma erythropoietin activity in male rabbits of the strain Chinchilla, which was statistically significant (p less than 0.01), but 4 hours after its application erythropoietin level was lowered with 68% in rabbits with a preceding hypoxia and intraperitoneal administration of Amanitin in comparison with nontreated hypoxic animals. The results were similar 48 hours after amanitin application as well. The results suggest that intraperitoneal administration of Amanita faloides before the onset of hypoxia diminishes erythropoietin production.
Nikolov
V
V
Logofetov
A
A
Kalaĭdzhieva
V
V
D000547:Amantadine / Q000633:toxicity*; D000818:Animals; D004921:Erythropoietin / Q000097:blood*; D000860:Hypoxia / Q000097:blood*; D008297:Male; D051379:Mice; D012319:RNA Polymerase II / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains
D004921:Erythropoietin; D000547:Amantadine; D012319:RNA Polymerase II
Eritropoetinova aktivnost na plazmata sled amanitinova intoksikatsiia i khipoksiia.