Methicillin resistance and beta-lactamase production in Staphylococcus aureus.
Staphylococcus aureus isolates were either sensitive, resistant or partially resistant (minimum inhibitory concentration 90 of 4 micrograms/ml) to methicillin. Low-level methicillin resistance was shown to be due to beta-lactamase production. The clinical significance of this beta-lactamase-mediated resistance is still unclear, so it is recommended that these strains should, at present, be regarded as methicillin-resistant.
de Villiers
F J
FJ
Department of Medical Microbiology, University of Pretoria.
Huygens
F
F
van Rensburg
A J
AJ
D000818:Animals; D008712:Methicillin / Q000494:pharmacology*; D010403:Penicillin Resistance; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology*; D001618:beta-Lactamases / Q000502:physiology*
D001618:beta-Lactamases; D008712:Methicillin