[Effectiveness of cycloplatam in the free form and included in liposomes during metastasis of GA-1 tumors in A/He mice].
The 6-10-fold freezing and thawing of routine multilamellar phospholipid vesicles in cycloplatam solution give rise to liposomes which entrap in their aqueous phase up to 10 mg of the drug per 100 mg of lipids. When injected intravenously to mice with HA-1 tumour metastases in the liver, liposome-encapsulated cycloplatam increased their survival rate by 112-123%, whereas free cycloplatam--only by 39-61% as compared to the control. The intramuscular transplants of the tumour were affected similarly by both liposome-encapsulated and free cycloplatam (the tumour growth was inhibited by 67.1 and 75.6%, respectively).
Kaledin
V I
VI
Chel'tsov
P A
PA
D000818:Animals; D000970:Antineoplastic Agents; D002850:Chromatography, Gel; D004304:Dosage Forms; D005260:Female; D008081:Liposomes; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000556:secondary; D051379:Mice; D008805:Mice, Inbred A; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D004304:Dosage Forms; D008081:Liposomes; D009944:Organoplatinum Compounds; C055928:cycloplatam
Effektivnost' tsikloplatama v svobodnoĭ forme i akliuchennogo v liposomy pri metastazirovanii opukholi GA-1 u mysheĭ linii A/He.