[Comparative characteristics of the interaction of several nonsteroidal anti-inflammatory agents with biomembranes in experimental inflammation].
The binding of sodium salicylate, sodium mefenamate, ortophen and piroxicam to membranes of erythrocyte ghosts and the effects of the drugs on the membrane microviscosity in carrageenan-induced inflammation were studied by the fluorescent probe method. It was shown that under inflammation the membrane microviscosity decreases and concurrently the affinity of the studied compounds to them increases. Antiphlogistics were found to enhance the membrane viscosity both in control and under inflammation. The possible mechanisms of the described effects of non-steroidal anti-inflammatory agents on biomembranes are discussed.
Mogilevich
S E
SE
Kul'chitskiĭ
A G
AG
Volovik
Z N
ZN
Sapotiuk
M V
MV
Klebanov
B M
BM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism* / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism*; D008560:Membrane Fluidity / Q000187:drug effects; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal
Sravnitel'naia kharakteristika vzaimodeĭstviia nekotorykh nesteroidnykh protivovospalitel'nykh sredstv s biomembranami pri éksperimental'nom vospalenii.