[Influence of Bacillus intermedius RNAase on thymus cell composition and T-lymphocyte differentiation in an experiment].
It was shown that exposure of mice AKR and (CBA X C57B1/6)F1 to Bacillus intermedius RNAase and its derivative selectively inactivated by the active centre histidine stimulated T-lymphocyte maturation. With using bone marrow and spleen lymphocytes of congenitally thymus-free mice it was revealed that this effect of RNAase was defined by induction of Thy-1 antigen of the lymphocyte plasmic membrane and not associated with homology of the enzyme primary structure and the alpha 1-thymosin structure.
Kurinenko
B M
BM
Nekhoroshkova
Z M
ZM
Kochergina
N I
NI
Iarilin
A A
AA
D000818:Animals; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000276:immunology / Q000494:pharmacology; D001407:Bacillus / Q000201:enzymology*; D002454:Cell Differentiation / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D007211:Indoles / Q000276:immunology* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D012260:Ribonucleases / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects*; D013947:Thymosin / Q000494:pharmacology; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects*
D007211:Indoles; D003208:Concanavalin A; D013947:Thymosin; D012260:Ribonucleases; D001205:Ascorbic Acid
Vliianie rnkazy Bacillus intermedius na kletochnyĭ sostav timusa i differentsirovku T-limfotsitov v éksperimente.