[Therapeutic effect of anisodamine on acute lung injury induced by oleic acid in dogs].
Acute lung injury was inflicted in 30 dogs with an intravenous injection of oleic acid of the dose 0.06 ml/kg. Half of the animals were treated with anisodamine. Another 5 dogs were injected with saline to serve as control. The dynamic changes of total hemolytic complement activity, neutrophil aggregation rate, platelet aggregation rate, fibrin degradation products, white cell count and platelet count in both the peripheral arterial and venous blood, and blood gas analysis were tested. The pathological and clinical changes were also observed. The results of the study suggest that the pathogenesis of oleic acid-induced acute lung injury was apparently related to the increase of complement activation, neutrophil aggregating activity, and blood coagulation. The therapeutic effect of anisodamine can be enhanced if the complement neutrophil-fibrin degradation products pathway is blocked.
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D000818:Animals; D004285:Dogs; D005260:Female; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000188:drug therapy*; D012991:Solanaceous Alkaloids / Q000494:pharmacology / Q000627:therapeutic use*
D009829:Oleic Acids; D012991:Solanaceous Alkaloids; C003922:anisodamine; D019301:Oleic Acid