title: Population bottlenecks in Polynesia revealed by minisatellites.
abstract: Tandem-repetitive highly variable loci in the human genome (minisatellites) have been used in gene mapping and as DNA "fingerprints", but they have not yet found much application in population genetics. We have investigate the capacity of six minisatellites to discriminate between four populations in Oceania. We find that in comparison to Melanesians, Polynesians have a significant loss of heterozygosity (or gene diversity), not noted using more traditional markers. We show also that the number of alleles, the allele distribution and the mutation rates at the Polynesian minisatellite loci do not deviate from those predicted by the neutral mutation/infinite allele model. The low gene diversity is therefore likely to be a result of the maintenance of small population sizes and bottleneck effects during the colonization of the Pacific.
authors: Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, UK.
authors: J
authors: J
authors: Flint
authors: A J
authors: AJ
authors: Boyce
authors: J J
authors: JJ
authors: Martinson
authors: J B
authors: JB
authors: Clegg
mesh_terms: D000483:Alleles; D004276:DNA, Satellite / Q000235:genetics*; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D011114:Polynesia
chemical_list: D004276:DNA, Satellite; D005819:Genetic Markers