Antiepileptic properties of cerebrospinal fluid after activation of the antiepileptic system of the brain.
Intraventricular injection of cerebrospinal fluid (CSF) obtained from cats with chronic electrical stimulation of cerebellar vermal cortex resulted in suppression of epileptic foci activity in cat brain cortex, an increase in time to first seizure, and weakening of generalized seizures in rats. The CSF obtained from cats after electroshock seizures induced less pronounced, although significant antiepileptic action in comparison with the CSF of cats with cerebellar stimulation on the model of generalized seizures in rats. The antiepileptic action of CSF obtained from cats with electrostimulation of cerebellar vermis and from electroshock cats is due to appearance of peptide factors in CSF.
Kryzhanovsky
G N
GN
Institute of General Pathology and Pathological Physiology, USSR Academy of Medical Sciences, Moscow.
Shandra
A A
AA
Godlevsky
L S
LS
Karganov
M Y
MY
D000818:Animals; D000927:Anticonvulsants; D002415:Cats; D002531:Cerebellum / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000032:analysis / Q000502:physiology*; D004558:Electric Stimulation; D004597:Electroshock; D004827:Epilepsy / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D010433:Pentylenetetrazole / Q000009:adverse effects; D010455:Peptides / Q000032:analysis / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000927:Anticonvulsants; D010455:Peptides; D010433:Pentylenetetrazole