title: Regional localization of the fibronectin and gamma-crystallin genes to bovine chromosome 8.
abstract: The genes for isocitrate dehydrogenase-1, fibronectin, and gamma-crystallin are syntenic in man, mouse, and cow. In an effort to assign this bovine syntenic group to a specific chromosome and to allow a cytological comparison of the conserved chromosomal region containing these genes in their respective species, we have localized the fibronectin and gamma-crystallin genes to bovine chromosome 8, region 1.1-1.4. This study incorporates the techniques of hybrid somatic cell analysis and in situ hybridization and the use of a Robertsonian-translocated marker chromosome from a related species for regional assignment of genes to a specific bovine chromosome. The regions on human chromosome 2q, mouse chromosome 1, and cow chromosome 8 that contain these genes are cytologically similar, perhaps representing evolutionary conservation at the cytogenetic level as well as at the gene level for this group of loci.
authors: Department of Veterinary Pathology, College of Veterinary Medicine, Texas A & M University, College Station 77843.
authors: S M
authors: SM
authors: Zneimer
authors: J E
authors: JE
authors: Womack
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D002871:Chromosome Banding; D002874:Chromosome Mapping; D003459:Crystallins / Q000235:genetics*; D015342:DNA Probes; D005353:Fibronectins / Q000235:genetics*; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: D003459:Crystallins; D015342:DNA Probes; D005353:Fibronectins; D007521:Isocitrate Dehydrogenase