[Interaction between erythromycin and carbamazepine].
A six-month-old girl receiving erythromycin was given carbamazepine treatment. Two days later signs of carbamazepine intoxication developed and a serum carbamazepine concentration of 30 mg/l was found (4-9 mg/l being the desired therapeutical level). The interaction of erythromycin and carbamazepine by liver enzyme competition is clinically significant.
Goldhoorn
P B
PB
Hofstee
N
N
D002220:Carbamazepine / Q000008:administration & dosage / Q000009:adverse effects*; D002524:Cerebellar Ataxia; D004347:Drug Interactions; D004359:Drug Therapy, Combination / Q000009:adverse effects; D004917:Erythromycin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007223:Infant; D002527:Myoclonic Cerebellar Dyssynergia / Q000150:complications / Q000188:drug therapy*; D012141:Respiratory Tract Infections / Q000150:complications / Q000188:drug therapy*
D002220:Carbamazepine; D004917:Erythromycin
Een interactie tussen erytromycine en carbamazepine.