Expression of CEA-related genes in the first trimester human placenta.
Eight cDNA clones, closely related to the carcino-embryonic antigen gene family, have been isolated from a cDNA library representing genes expressed in the first trimester human placenta. Sequence analysis of one clone shows it to be a pregnancy-specific beta 1-glycoprotein (PS beta G) closely related to three other PS beta G cDNA recently characterised from a term placenta library. The protein encoded by the cDNA is predicted to be less high glycosylated than those reported previously and differs markedly in the C-terminal sequence. The 3' untranslated region of the cDNA is very similar to the equivalent region of beta 1-glycoprotein PS beta G E except that it contains the 12bp repeat sequence found flanking the Alu sequence in CEa and an additional 67bp of sequence that appears to be derived from CEA.
McLenachan
T
T
Department of Microbiology and Genetics, Massey University, Palmerston North, New Zealand.
Mansfield
B
B
D000595:Amino Acid Sequence; D001483:Base Sequence; D015152:Blotting, Northern; D002272:Carcinoembryonic Antigen / Q000235:genetics*; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000235:genetics*; D011263:Pregnancy Trimester, Third; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000235:genetics* / Q000648:ultrastructure; D012333:RNA, Messenger / Q000235:genetics; D015183:Restriction Mapping
D002272:Carcinoembryonic Antigen; D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins; D012333:RNA, Messenger; D004247:DNA