Release of VIP- but not CGRP-like immunoreactivity by capsaicin from the human isolated small intestine.
Exposure to capsaicin (1 microM) produced a prompt and sustained release of vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) from mucosa-free strips of human small intestine (jejunum and ileum). A second application of capsaicin, 60 min later, had no effect indicating complete desensitization, a specific feature of the action of capsaicin on sensory nerves. By contrast no release of calcitonin gene-related peptide (CGRP)-LI was produced upon the first or second application of capsaicin.
Maggi
C A
CA
Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
Santicioli
P
P
Del Bianco
E
E
Geppetti
P
P
Barbanti
G
G
Turini
D
D
Meli
A
A
D000368:Aged; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000187:drug effects; D009479:Neuropeptides / Q000378:metabolism*; D011863:Radioimmunoassay; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D009479:Neuropeptides; D014660:Vasoactive Intestinal Peptide; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin