Effect of rokitamycin on human polymorphonuclear leukocyte chemotaxis.
The effect of rokitamycin on human polymorphonuclear leukocyte (PMNL) chemotaxis was studied in vitro and in vivo. It was found that rokitamycin in vitro at a concentration of 20 micrograms/ml caused a diminution of PMNL migration, while at lower concentrations no significant effects on migration was observed. In in-vivo studies before and after the ingestion of rokitamycin by six healthy individuals, no change on PMNL chemotaxis was found.
Torre
D
D
Division of Infectious Diseases, Regional Hospital, Varese, Italy.
Broggini
M
M
Rossi
S
S
Sampietro
C
C
Bottà
V
V
D000328:Adult; D002465:Cell Movement / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D015644:Miocamycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects
D015644:Miocamycin; C033383:rokitamycin