title: Stimulation of ovine placental calcium transport by purified natural and recombinant parathyroid hormone-related protein (PTHrP) preparations.
abstract: Perfusion in situ of the placenta of previously thyroparathyroidectomized fetal lambs has been used to compare the ability of various forms of parathyroid hormone-related protein (PTHrP) to stimulate placental calcium transport. Whereas PTHrP (1-34) was without effect, PTHrP (1-141) was active but usually after a delay of up to 1 h, in common with the effect noted when using extracts of fetal parathyroid glands. In contrast, PTHrP (1-84) and PTHrP (1-108), tended to show a more rapid stimulatory action. It is suggested that post-translational processing of PTHrP (1-141) may occur as an activating step in the placenta in vivo.
authors: Department of Animal Physiology and Nutrition, University of Leeds.
authors: S K
authors: SK
authors: Abbas
authors: D W
authors: DW
authors: Pickard
authors: C P
authors: CP
authors: Rodda
authors: J A
authors: JA
authors: Heath
authors: R G
authors: RG
authors: Hammonds
authors: W I
authors: WI
authors: Wood
authors: I W
authors: IW
authors: Caple
authors: T J
authors: TJ
authors: Martin
authors: A D
authors: AD
authors: Care
mesh_terms: D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D009363:Neoplasm Proteins / Q000494:pharmacology*; D010281:Parathyroid Hormone / Q000032:analysis; D044162:Parathyroid Hormone-Related Protein; D010477:Perfusion; D010920:Placenta / Q000378:metabolism*; D011994:Recombinant Proteins / Q000494:pharmacology; D012756:Sheep / Q000502:physiology; D013965:Thyroidectomy; D013997:Time Factors
chemical_list: D009363:Neoplasm Proteins; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011994:Recombinant Proteins; D002118:Calcium