[Lipid peroxidation and the polymerase activities of liver chromatin fractions in rats during aging].
Lipids, which enter the composition of actively transcribed and repressed chromatin fractions are found to undergo a peroxidation. This process decreased with aging and more pronounced in actively transcribed chromatin fraction. A decreased activity of DNA polymerase beta and increased activity of RNA polymerase I in this chromatin fraction with aging were observed. It is assumed that observed changes of genome function of old animals may be caused by decreased peroxidation of chromatin lipids.
Levitskiĭ
E L
EL
Gubskiĭ
Iu I
IuI
Gol'dshteĭn
N B
NB
Litoshenko
A Ia
AIa
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014158:Transcription, Genetic
D002843:Chromatin; D012321:DNA-Directed RNA Polymerases; D004259:DNA-Directed DNA Polymerase
Perekisnoe okislenie lipidov i polimeraznye aktivnosti fraktsiĭ khromatina pecheni krys pri starenii.