The leukocyte integrins.
During the 1980s, various laboratories identified a rare type of patient suffering from recurrent bacterial infections whose neutrophils showed reduced spreading on surfaces. Such leukocyte adhesion deficient (LAD) patients were shown to lack a trio of molecules named either LFA-1, CR3/Mac-1/Mo1, p150,95/CR4 or CD11, CD18 or the leukocyte integrin family. In September 1988, the first meeting exclusively devoted to this topic was held.
Hogg
N
N
D000954:Antigens, Surface / Q000235:genetics; D002448:Cell Adhesion; D003001:Cloning, Molecular; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D016023:Integrins; D007962:Leukocytes / Q000166:cytology* / Q000276:immunology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology*; D009154:Mutation; D009504:Neutrophils / Q000166:cytology / Q000276:immunology
D000954:Antigens, Surface; D016023:Integrins; D008562:Membrane Glycoproteins