Enhancing effect of suspended particulate matter on the IgE antibody production in mice.
Suspended particulate matter (SPM), suspended in the polluted environmental atmosphere, are perpetually inhaled into the human body and are considered to have profound effects on human health. This study investigated the enhancing effect of SPM on the IgE antibody production in mice. The IgE antibody responses in mice immunized with intranasal administration of ovalbumin (OA) plus SPM at 3-week intervals were higher than responses in the animals immunized with OA alone. When the dose of OA administered as an antigen was 0.25 microgram, the time course and magnitude of enhancement by SPM was comparable to those by killed Bordetella pertussis, a common adjuvant. SPM had an enhancing effect on IgE antibody production even in a small dose such as 0.25 microgram administered at 3-week intervals. The possibility cannot be excluded that the natural exposure of humans to SPM in the environmental atmosphere may explain the high prevalence rate of allergic rhinitis caused by pollens in polluted districts in Japan.
Takafuji
S
S
Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan.
Suzuki
S
S
Koizumi
K
K
Tadokoro
K
K
Ohashi
H
H
Muranaka
M
M
Miyamoto
T
T
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000281:Administration, Intranasal; D000327:Adsorption; D000393:Air Pollutants; D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D004334:Drug Administration Schedule; D005260:Female; D007073:Immunoglobulin E / Q000096:biosynthesis*; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D010316:Particle Size; D013535:Suspensions
D000276:Adjuvants, Immunologic; D000393:Air Pollutants; D013535:Suspensions; D007073:Immunoglobulin E; D010047:Ovalbumin