[Effects of glucocorticoid therapy on membrane markers of lymphocytes and monocytes in children with chronic idiopathic thrombocytopenic purpura].
The treatment with glucocorticoids brings about a decrease in the expression of Ia-like and LFA-J antigens on the membrane surface of peripheral blood lymphocytes and monocytes, diminution of the relative count of monocytes with fixed immunoglobulins (with Fc-receptors). A reduction of the count of B lymphocytes and monocytes with Ia and LFA-J antigens in the spleen was recorded. The hematologic effect attained in the treatment with glucocorticoids was determined by the combined effect of the drugs: by the blockade of monocyte/macrophage receptors and by the redistributiion++ action of prednisolone leading to the release of blood platelets from the bone marrow to the blood bed.
Torubarova
N A
NA
Koshe'l
I V
IV
Mambetova
Ch D
ChD
D000293:Adolescent; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D002462:Cell Membrane / Q000187:drug effects / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use*; D011696:Purpura, Thrombocytopenic / Q000097:blood / Q000188:drug therapy*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000473:pathology
D015415:Biomarkers; D011239:Prednisolone
Vliianie gliukokortikoidnoĭ terapii na membrannye markery limfotsitov i monotsitov u deteĭ s khronicheskoĭ idio- paticheskoĭ trombotsitopenicheskoĭ purpuroĭ.