Calcium channel inhibitors prevent apomorphine- and oxytocin-induced penile erection and yawning in male rats.
The effect of i.p. injection of the calcium channel inhibitors, verapamil, flunarizine, nifedipine, nimodipine and nicardipine, on penile erection and yawning induced by the dopamine agonist, apomorphine, or by oxytocin was studied in male rats. The five compounds antagonized in a dose-dependent manner the behavioral responses induced either by apomorphine or oxytocin. Nimodipine and nicardipine were found to be the most potent, being active in doses between 5 and 20 mg/kg, while nifedipine, verapamil and flunarizine were active in doses higher than 15 mg/kg. The results suggest that calcium is involved in the expression of the above-mentioned behavioural responses.
Argiolas
A
A
Department of Neurosciences, University of Cagliari, Italy.
Melis
M R
MR
Gessa
G L
GL
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors*; D001522:Behavior, Animal / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D010121:Oxytocin / Q000037:antagonists & inhibitors*; D010410:Penile Erection / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D015000:Yawning / Q000187:drug effects*
D002121:Calcium Channel Blockers; D010121:Oxytocin; D001058:Apomorphine