Variations of serum lipoproteins during cell proliferation induced by lead nitrate.
In the present study serum lipoproteins were investigated during cell proliferation induced by a potent mitogen, lead nitrate. A strong decrease in HDL2 and a concomitant increase in HDL3 were observed in lead-treated rats. The recovery of normal lipoprotein pattern took place together with the regression of hyperplastic process. Since a decrease in HDL also occurs under other conditions of cell growth, we hypothesize that a decrease in HDL, mainly in HDL2 subfraction, may represent a generalized phenomenon related to massive cell proliferation.
Dessí
S
S
Istituto di Farmacologia e Patologia Biochimica, University of Cagliari, Italy.
Batetta
B
B
Carrucciu
A
A
Pulisci
D
D
Laconi
S
S
Fadda
A M
AM
Anchisi
C
C
Pani
P
P
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D007854:Lead / Q000494:pharmacology*; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D009566:Nitrates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D009566:Nitrates; D007854:Lead; C017461:lead nitrate; D002784:Cholesterol