Value of monitoring serum gastrin after renal transplantation.
Serum concentration of gastrin was measured before and after renal transplantation in 97 consecutive patients in order to assess possible correlations to gastrointestinal bleeding, allograft function, or graft rejection. In patients with transient signs of allograft rejection (N = 29) or upper gastrointestinal bleeding (N = 12) there was a nonsignificant trend towards higher postoperative gastrin levels, and in patients in whom the graft was removed (N = 29), this tendency was more pronounced (p = 0.06). The study demonstrated that monitoring of serum concentrations of gastrin following renal transplantation is of little clinical value. However, increased gastrin levels in serum may indicate that graftectomy may be the ultimate result.
Pedersen
J H
JH
Department of Surgery C, Rigshospitalet, Copenhagen.
Walter
S
S
Andersen
J T
JT
Stadil
F
F
D002102:Cadaver; D002927:Cimetidine / Q000097:blood / Q000627:therapeutic use; D005260:Female; D005755:Gastrins / Q000097:blood*; D006471:Gastrointestinal Hemorrhage / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D006084:Graft Rejection / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007432:Intraoperative Period; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D010439:Peptic Ulcer Perforation / Q000097:blood; D011237:Predictive Value of Tests
D005755:Gastrins; D007166:Immunosuppressive Agents; D002927:Cimetidine