title: [Effect of increasing amounts of clonidine during hyperbaric tetracaine spinal anesthesia].
abstract: The effect of adding clonidine to hyperbaric tetracaine spinal anesthesia was investigated in 60 ASA class I-II patients scheduled for orthopedic and lower abdominal surgery. The subjects were randomly allocated into 4 groups. All patients received tetracaine 10 mg in 10% glucose solution 2 mL. Patients in group 1 received above medication and were the control group, patients in the other groups received tetracaine plus increasing dosages of clonidine: 15 microgram (Gr.2), 30 microgram (Gr.3), and 45 microgram (Gr.4). The segmental level of sensory loss was tested by the pinprick method using a 23 G needle. The three clonidine groups had significantly increased in the sensory regression time to L1 level (by 42, 47, 60% respectively), and also had significantly increased motor complete recovery time (by 48, 70, 74% respectively), but the incidence of hypotension and bradycardia was increased in the clonidine 0.045 mg group. It is concluded that addition of 15 or 30 microgram clonidine may be useful as a means of increasing the duration of hyperbaric tetracaine spinal anesthesia.
authors: C I
authors: CI
authors: Wu
authors: J J
authors: JJ
authors: Wang
authors: F S
authors: FS
authors: Ning
authors: C H
authors: CH
authors: Chao
authors: R J
authors: RJ
authors: Liu
authors: C H
authors: CH
authors: Chen
authors: M S
authors: MS
authors: Mok
mesh_terms: D000328:Adult; D000775:Anesthesia, Spinal / Q000379:methods*; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013046:Specific Gravity; D013748:Tetracaine / Q000008:administration & dosage*
chemical_list: D013748:Tetracaine; D003000:Clonidine