High magnesium diets increase blood pressure and enhance stroke mortality in hypertensive SHRsp rats.
The effect of varying amounts of dietary magnesium in conjunction with potassium (K) on hypertension and stroke mortality in hypertensive stroke prone (SHRsp) rats was studied. These results show that high K (2.1%) diets strongly protect against stroke mortality and rises of blood pressure, while high magnesium (Mg) (0.26%) diets appeared to increase stroke mortality and accelerate the rise of blood pressure in SHRsp rats. Similarly, medium-high (1.3%) levels of K in the diet significantly reduced blood pressure and stroke mortality but not nearly as much as the 2.1% K in the high K diet.
Ganguli
M
M
Department of Medicine, University of Minnesota Hospital and School of Medicine, Minneapolis 55455.
Tobian
L
L
Sugimoto
T
T
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000401:mortality*; D004032:Diet; D004198:Disease Susceptibility; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008274:Magnesium / Q000008:administration & dosage / Q000494:pharmacology*; D011188:Potassium / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR
D008274:Magnesium; D011188:Potassium