Cholecystokinin interferes with the thermoregulatory effect of exogenous and endogenous opioids.
Intraperitoneal (ip) injection of cholecystokinin octapeptide sulfate ester (CCK; 5, 10 and 50 micrograms/kg) reduced the hypothermic response to 8 mg/kg and 32 mg/kg systemic morphine in restrained and freely moving rats, respectively. The hyperthermia elicited by a subcutaneous (sc) injection of 8 mg/kg morphine to freely moving rats was not diminished by CCK pretreatment. CCK (5 micrograms/kp ip) completely prevented the restraint stress-induced hyperthermia. Naloxone (1 mg/gk sc) was effective in antagonizing both the hyperthermic and the hypothermic effects of morphine and the stress-induced emotional hyperthermia. These results support the hypothesis that CCK may contribute to regulation of the endogenous opioid system.
Kapás
L
L
Department of Physiology, Albert Szent-Györgyi University Medical School, Szeged, Hungary.
Benedek
G
G
Penke
B
B
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002766:Cholecystokinin / Q000494:pharmacology*; D004723:Endorphins / Q000502:physiology*; D006979:Hyperthermia, Induced; D007036:Hypothermia, Induced; D007274:Injections, Intraperitoneal; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D004723:Endorphins; D009270:Naloxone; D009020:Morphine; D002766:Cholecystokinin