The study on cell surface antigens in epithelial tumor of the upper urinary tract: ABH-isoantigen and Thomsen-Friedenreich antigen.
ABH-isoantigen (ABH-Ag) and Thomsen-Friedenreich antigen (T-Ag) were investigated by the Avidin-Biotin-Peroxidase Complex (ABC) method on 47 patients with epithelial tumor of the upper urinary tract (all patients underwent nephroureterectomy including the cuff of the bladder; 30 patients were diagnosed as transitional cell carcinoma of renal pelvis and 17 ureteral organs). The correlations between ABC expression for ABH-Ag and T-Ag with histological grade, stage and prognosis (5 year survival rate) were studied. A correlation was observed between grade (p less than 0.05) and deletion of the antigenicity of ABH-Ag, but no correlation was evident with stage and prognosis. A high correlation was evident, however, between grade (p less than 0.01), stage (p less than 0.01) and prognosis (p less than 0.01) and deletion of the antigenicity of T-Ag. The analysis of ABC expression for ABH-Ag and T-Ag may therefore be valuable for predicting the malignant potential in transitional cell carcinoma of the upper urinary tract. T-Ag determination in particular may provide a useful prognostic probe should it find clinical application.
Fukatsu
H
H
Department of Urology, Aichi Medical University.
Nonomura
H
H
Miyagawa
Y
Y
Waki
M
M
Hatano
Y
Y
Hiraiwa
S
S
Muramatsu
T
T
Nishikawa
E
E
Yamada
Y
Y
Satoh
T
T
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015295:Antigens, Tumor-Associated, Carbohydrate; D002295:Carcinoma, Transitional Cell / Q000276:immunology*; D004187:Disaccharides / Q000032:analysis*; D005260:Female; D006801:Humans; D007519:Isoantigens / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D014571:Urologic Neoplasms / Q000276:immunology*
D000017:ABO Blood-Group System; D015295:Antigens, Tumor-Associated, Carbohydrate; D004187:Disaccharides; D007519:Isoantigens; C016467:Thomsen-Friedenreich antigen