Decreased levels of pathogenic IgG anti-DNA antibodies in autoimmune mice after linomide treatment.
Treatment with a novel immunomodulator called linomide resulted in highly reduced levels of pathogenic anti-DNA antibodies in MRL-lpr/lpr mice compared to untreated mice. This reduction occurred without altering the total levels of serum immunoglobulins, implying that the compound does not have any direct B-cell suppressive effect. The possible role of T cells in regulating autoreactive B-cell clones is discussed.
Spetz-Hagberg
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Unité de Biologie Moléculaire du Gène, U277 INSERM-UAC 115 CNRS, Institut Pasteur, Paris.
Larsson-Sciard
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D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D004247:DNA / Q000276:immunology; D006912:Hydroxyquinolines / Q000627:therapeutic use*; D007074:Immunoglobulin G / Q000378:metabolism; D007674:Kidney Diseases / Q000188:drug therapy; D051379:Mice; D008817:Mice, Mutant Strains; D013601:T-Lymphocytes / Q000145:classification / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D001323:Autoantibodies; D006912:Hydroxyquinolines; D007074:Immunoglobulin G; C045282:roquinimex; D004247:DNA