[Effect of procaine and procaine metabolites on coenzyme A and acetyl coenzyme A concentration in various tissues of the rat].
In rats treated with procaine hydrochloride, diethylaminoethanol, monoethylaminoethanol, ethanolamine, as well as a combination of procaine hydrochloride and haematoporphyrine the ratio of acetyl coenzyme A and coenzyme A clearly was enhanced in the liver and to a minor extent in the cerebellum. In the tissue of cerebral cortex, heart, muscle and duodenum no corresponding effects were demonstrated. These findings, showing a further intermediary effect of orally administered procaine, can be interpreted as an influence in intermediary energy utilisation.
Kietzmann
M
M
Institut für Pharmakologie, Toxikologie und Pharmazie, Tierärztliche Hochschule Hannover.
Kaemmerer
K
K
D000105:Acetyl Coenzyme A / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D003065:Coenzyme A / Q000378:metabolism*; D004338:Drug Combinations; D004386:Duodenum / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D019856:Ethanolamine; D004983:Ethanolamines / Q000494:pharmacology*; D006415:Hematoporphyrins / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects; D008297:Male; D009132:Muscles / Q000187:drug effects; D011343:Procaine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D004338:Drug Combinations; D004983:Ethanolamines; D006415:Hematoporphyrins; D011343:Procaine; D019856:Ethanolamine; D000105:Acetyl Coenzyme A; C007369:2-diethylaminoethanol; D003065:Coenzyme A
Einfluss von Procain und Procain-Metaboliten auf die Coenzym A- und Acetyl-Coenzym A-Konzentration in verschiedenen Geweben der Ratte.