Oscillatory potentials of X-linked carriers of congenital stationary night blindness.
ERG oscillatory potentials (OPs) were recorded from obligate carriers of CSNB and from age-matched normal subjects. The OPs were recorded under four stimulus conditions and were analyzed in the time and frequency domains. The results, first of all, provide confirmation of the previous report that the OP amplitude is reduced in carriers. Second, the results show that, of four stimulus conditions examined, the best condition for discriminating the carriers and normal subjects was when the flash was blue and the eye was dark-adapted. Third, the results show that, in the frequency domain, optimal discrimination occurs when examining the power content of the OP at a center frequency of about 130 Hz using a 70 Hz bandwidth window. In the time domain, optimal discrimination occurs when examining the amplitude of the third peak of the response.
Young
R S
RS
Department of Ophthalmology and Visual Sciences, Texas Tech Health Sciences Center, Lubbock 79430-0001.
Chaparro
A
A
Price
J
J
Walters
J
J
D004596:Electroretinography; D005069:Evaluation Studies as Topic; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods; D006579:Heterozygote; D006801:Humans; D009755:Night Blindness / Q000151:congenital* / Q000503:physiopathology; D012016:Reference Values; D012160:Retina / Q000503:physiopathology*; D014960:X Chromosome