title: The structure of ulithiacyclamide B. Antitumor evaluation of cyclic peptides and macrolides from Lissoclinum patella.
abstract: The major cytotoxic metabolites of Lissoclinum patella from Pohnpei have been isolated and identified. Most of the cytotoxicity is attributed to a new cyclic peptide, ulithiacyclamide B [4], which is closely related to ulithiacyclamide [1]. The proposed structure of 4 is based on spectroscopic analysis and chemical degradation. Compound 4 exhibits an IC50 of 17 ng/ml against the KB cell line but does not show selective cytotoxicity against solid tumor cells in the Corbett assay.
authors: Department of Chemistry, University of Hawaii Manoa, Honolulu 96822.
authors: D E
authors: DE
authors: Williams
authors: R E
authors: RE
authors: Moore
authors: V J
authors: VJ
authors: Paul
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D006868:Hydrolysis; D007939:Leukemia L1210 / Q000188:drug therapy; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010456:Peptides, Cyclic / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D014230:Triazoles / Q000032:analysis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D018942:Macrolides; D010456:Peptides, Cyclic; D014230:Triazoles; C061628:ulithiacyclamide B