title: Tryptamine alkaloid toxicosis in feedlot sheep.
abstract: Tryptamine alkaloid toxicosis (Phalaris staggers) was diagnosed in feedlot sheep. Clinical signs of toxicosis, which were exacerbated by excitement, included gait abnormalities, muscular tremors, nystagmus, and convulsions. An estimated 8% of the most severely affected lambs had clinical signs of toxicosis. Gross lesions detected in the brain of affected lambs consisted of focal gray-green discoloration in the brain stem and thalamus; these areas had microscopic evidence of intraneuronal pigment accumulation. Brain specimens obtained at slaughter indicated that 60% of the lambs had lesions consistent with tryptamine alkaloid toxicosis. Tryptamine alkaloids were found in low concentrations in the feed. Lambs exposed to these feeds had higher death losses than those that were not exposed to the feeds. Cobalt concentration in the feed was higher than that previously reported to be associated with Phalaris staggers.
authors: Veterinary Medicine Teaching and Research Center, University of California, Davis 18830.
authors: I J
authors: IJ
authors: Lean
authors: M
authors: M
authors: Anderson
authors: M G
authors: MG
authors: Kerfoot
authors: G C
authors: GC
authors: Marten
mesh_terms: D000470:Alkaloids / Q000506:poisoning*; D000821:Animal Feed / Q000506:poisoning*; D000818:Animals; D001921:Brain / Q000473:pathology; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced* / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology; D014363:Tryptamines / Q000506:poisoning*
chemical_list: D000470:Alkaloids; D014363:Tryptamines