[Initial results in man of immunolymphoscintigraphy of cancer of the prostate].
The loco-regional investigation of carcinoma of the prostate usually comprises ilio-obturator lymphadenectomy. This procedure carries a significant morbidity. Immunolymphoscintigraphy may provide a non-invasive alternative to this operation. Monoclonal (MAB) 227 A anti-prostatic acid phosphatase antibodies have been produced and selected for their affinity and specificity. This MAB was fragmented to its F (ab')2 form and marked with Iodine 123. Fifteen patients with prostate cancer were given 100 to 400 micrograms of the MAB by periprostatic perineal injection. The region was scanned 1 hr, 3 hrs, 6 hrs and 24 hrs after the injection. The results of the immunolymphoscintigraphy were compared with the histology of the ganglia removed at surgery or needle biopsy guided by CT scanning. In 13 cases the results were concordant for the two techniques (10 negatives and 3 positives). Two patients showed extra-prostatic fixation whilst the histology remained negative. Immunolymphoscintigraphy may therefore provide a simple method of detecting local metastases of carcinoma of the prostate if these initial results are confirmed.
Teillac
P
P
Service d'Urologie, Hôpital Saint-Louis, Paris.
Leroy
M
M
Rain
J D
JD
Bruneau
J
J
Cheval
E
E
Ketels
F
F
Rabaud
B
B
Saccavini
J C
JC
Najean
Y
Y
Le Duc
A
A
D000368:Aged; D000911:Antibodies, Monoclonal; D006801:Humans; D007457:Iodine Radioisotopes; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes
Premiers résultats chez l'homme de l'immunolymphoscintigraphie dans le cancer de prostate.