title: In vivo effects of zinc and chlorhexidine on dental plaque ureolysis and glycolysis.
abstract: We assessed the in vivo effects of zinc and chlorhexidine (CH) on plaque ureolysis and glycolysis in five volunteers. We monitored plaque pH by a surface glass electrode on two teeth in each subject, after topical application of either 5% wt/vol urea or 5% wt/vol glucose solutions. The recordings were repeated 15 and 75 min after a single mouthrinse, with either 20 mmol/L zinc acetate or 0.33 mmol/L CH diacetate. Ureolytic activity decreased significantly (p less than 0.03) up to 75 min after a single mouthrinse with the zinc-containing test solution. CH had no effect on plaque ureolytic activity. Acid production by dental plaque decreased significantly (p less than 0.01) up to 75 min after a single mouthrinse with either the zinc- or the CH-containing test solution.
authors: Department of Pedodontics and Caries Prophylaxis, Faculty of Dentistry, University of Oslo, Norway.
authors: E
authors: E
authors: Giertsen
authors: A A
authors: AA
authors: Scheie
authors: G
authors: G
authors: Rölla
mesh_terms: D000328:Adult; D002710:Chlorhexidine / Q000494:pharmacology*; D003773:Dental Plaque / Q000378:metabolism*; D005260:Female; D006019:Glycolysis / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D009067:Mouthwashes / Q000494:pharmacology; D014508:Urea / Q000378:metabolism*; D015032:Zinc / Q000494:pharmacology*
chemical_list: D009067:Mouthwashes; D014508:Urea; D015032:Zinc; D002710:Chlorhexidine