title: Chlorhexidine rinse in prevention of dental caries in patients following radiation therapy.
abstract: Patients who receive cancer radiotherapy, which compromises salivary gland function, may develop xerostomia. These patients are at increased risk to develop rampant dental caries. Streptococcus mutans and species of lactobacillus have been associated with dental caries. Quantitative counts of these organisms demonstrated high caries risk in 85% of patients studied. The use of chlorhexidine rinse to reduce the counts of S. mutans and lactobacillus was studied. A modest reduction in S. mutans was seen, but little effect was demonstrated on lactobacillus counts. Caries activity was shown to be related to lactobacillus count.
authors: Cancer Control Agency of British Columbia, Vancouver, Canada.
authors: J B
authors: JB
authors: Epstein
authors: R
authors: R
authors: Loh
authors: P
authors: P
authors: Stevenson-Moore
authors: B C
authors: BC
authors: McBride
authors: J
authors: J
authors: Spinelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002710:Chlorhexidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004245:DMF Index; D003731:Dental Caries / Q000209:etiology / Q000517:prevention & control*; D003733:Dental Caries Susceptibility; D005260:Female; D006801:Humans; D007778:Lactobacillus / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes; D011878:Radiotherapy / Q000009:adverse effects*; D012463:Saliva / Q000378:metabolism / Q000382:microbiology; D013295:Streptococcus mutans / Q000302:isolation & purification; D014987:Xerostomia / Q000209:etiology
chemical_list: D009067:Mouthwashes; D002710:Chlorhexidine