Lipid peroxidation in open-angle glaucoma.
UV-spectrophotometry and fluorescent analysis were used to study lipid extracts from lenses, aqueous humour and blocks containing trabecular and Schlemms canal tissues, obtained from 49 eyes of patients with primary open-angle glaucoma (POAG). Accumulation of the primary, secondary, and end products of lipid peroxidation (LPO) (diene and triene conjugates, Schiff's bases) was noted in the studied extracts. Significant differences in the levels of all the mentioned LPO products in comparison with the control were observed. The data may be considered as an evidence of LPO participation in destruction of the trabecule and Schlemm's canal in POAG.
Babizhayev
M A
MA
Moscow Helmholtz Research Insitute of Eye Diseases, USSR.
Bunin AYa
D000328:Adult; D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism; D002386:Cataract / Q000378:metabolism; D005902:Glaucoma, Open-Angle / Q000378:metabolism*; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism; D050356:Lipid Metabolism; D008875:Middle Aged; D010084:Oxidation-Reduction; D014129:Trabecular Meshwork / Q000473:pathology