Clinical value of a pathological examination in a case of first trimester trisomy 18.
An unexpected case of trisomy 18 was diagnosed after a chorionic villous biopsy at 9 weeks gestation, obtained to exclude a probable case of sickle cell disease. Difficulties in confirming the original diagnosis after fetal tissue culture are examined. The value of pathological examination of the termination specimen is emphasized.
Moscoso
G
G
Department of Morbid Anatomy, King's College Hospital, London, UK.
Rosevear
S
S
Nandra
C
C
Nicolaides
K H
KH
D000328:Adult; D002887:Chromosomes, Human, Pair 18; D005260:Female; D005333:Fetus; D006330:Heart Defects, Congenital / Q000175:diagnosis*; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014314:Trisomy