Adult-onset metachromatic leucodystrophy presenting without psychiatric symptoms.
A 24-year-old man presented with a spastic and ataxic condition resembling chronic-progressive multiple sclerosis. Radiological examination revealed symmetrical diffuse paraventricular demyelination. Electrophysiological findings suggested additional involvement of the brain stem and the peripheral nervous system. The diagnosis of adult-onset metachromatic leucodystrophy was confirmed by biochemical and ultrastructural examination. In contrast to almost all adult cases reported so far, psychiatric symptoms were not present.
Klemm
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Department of Neurology, University of Bonn, Federal Republic of Germany.
Conzelmann
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E
D000328:Adult; D001241:Aspirin / Q000097:blood / Q000652:urine; D001706:Biopsy; D003937:Diagnosis, Differential; D004594:Electrophysiology; D005192:Family Health; D006801:Humans; D007966:Leukodystrophy, Metachromatic / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis*; D012007:Rectum / Q000473:pathology; D014057:Tomography, X-Ray Computed
D001241:Aspirin