Myocardial free-radical injury after cardioplegia.
Although cold blood cardioplegia provides excellent myocardial protection for elective coronary bypass surgery, myocardial metabolic recovery is delayed postoperatively, perhaps because of free-radical injury during reperfusion. To assess free-radical reperfusion injury, we measured the products of lipid peroxidation and the cardiac concentrations of alpha tocopherol in 10 patients undergoing elective surgical revascularization. Arterial and coronary sinus blood measurements revealed a delayed recovery of myocardial oxygen consumption and lactate utilization and the myocardial release of conjugated dienes (chemical signatures of free-radical injury) at 3 and 60 minutes after reperfusion. In addition, myocardial concentrations of alpha tocopherol decreased after reperfusion, suggesting consumption of the major membrane antioxidant. These results support the hypothesis that oxygen-derived free radicals contribute to myocardial injury after cardioplegic arrest and that antioxidant therapy should improve myocardial protection.
Weisel
R D
RD
Division of Cardiovascular Surgery, Toronto General Hospital, Ontario, Canada.
Mickle
D A
DA
Finkle
C D
CD
Tumiati
L C
LC
Madonik
M M
MM
Ivanov
J
J
Burton
G W
GW
Ingold
K U
KU
D005609:Free Radicals; D006324:Heart Arrest, Induced; D006801:Humans; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D015227:Lipid Peroxidation; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000209:etiology* / Q000378:metabolism; D009204:Myocardial Revascularization; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000633:toxicity*; D010101:Oxygen Consumption; D013997:Time Factors; D014810:Vitamin E / Q000378:metabolism
D005609:Free Radicals; D007773:Lactates; D014810:Vitamin E; D019344:Lactic Acid; D010100:Oxygen