Hydrophobic moieties in cations, anions, and alcohols promote the B-to-Z transition in poly[d(G-C)] and poly[d(G-m5C)].
Previous results from our laboratory showed that an increase in the nonpolar alkyl chain length in tetraalkylammonium cations is accompanied by greater efficiency in driving the B-to-Z transition. Analogous effects are observed when the hydrocarbon portion of carboxylate anions and alcohols is increased in size. The more hydrophobic species have a greater ordering effect on the aqueous solvent and promote formation of the less hydrated Z-DNA conformer.
McDonnell
N B
NB
Department of Chemistry, Towson State University, MD 21204.
Preisler
R S
RS
D000438:Alcohols / Q000378:metabolism; D000838:Anions / Q000378:metabolism; D002412:Cations / Q000378:metabolism; D002942:Circular Dichroism; D004247:DNA / Q000378:metabolism*; D011089:Polydeoxyribonucleotides / Q000378:metabolism*
D000438:Alcohols; D000838:Anions; D002412:Cations; D011089:Polydeoxyribonucleotides; C019530:poly(dC-dG); D004247:DNA