[Specific binding of androgens by the skin in hirsutism of ovarian genesis].
The role of raised skin sensitivity to circulating androgens in the pathogenesis of hirsutism, determined by the syndrome of polycystic ovaries, was studied. A two-fold increase in the specific binding of 3H-methyltrienolone++ was noted in the cytosol fraction of the public skin of women suffering from hirsutism as compared to healthy women using saturation analysis. The specific binding of androgens indicated an increase in the content of androgen receptors of the skin in hirsutism.
Tarasenko
L V
LV
Varga
S V
SV
Sinitsyn
P V
PV
D000328:Adult; D001667:Binding, Competitive; D003600:Cytosol / Q000378:metabolism; D004963:Estrenes / Q000378:metabolism*; D005260:Female; D006628:Hirsutism / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D015741:Metribolone; D010053:Ovary / Q000503:physiopathology*; D011944:Receptors, Androgen / Q000378:metabolism; D012867:Skin / Q000378:metabolism*; D045165:Testosterone Congeners / Q000378:metabolism*
D004963:Estrenes; D011944:Receptors, Androgen; D045165:Testosterone Congeners; D015741:Metribolone
Spetsificheskoe sviazyvanie androgenov kozheĭ pri girsutizme ovarial'nogo geneza.