Sulconazole nitrate cream 1 percent for treating tinea cruris and corporis.
Sulconazole nitrate 1 percent cream, a new imidazole derivative, was tested in 117 Colombian Army soldiers with tinea cruris/corporis under hot, humid conditions. The results of two clinical trials demonstrate that sulconazole applied once daily was as effective as clotrimazole applied twice daily. After three weeks of therapy 100 percent of the patients treated either once or twice daily with sulconazole showed negative findings on potassium hydroxide preparations and cultures from lesions. Although sulconazole was well tolerated and caused no adverse reactions, four of twenty-seven clotrimazole-treated patients showed reactions consisting of erosive primary irritation. Sulconazole nitrate 1 percent cream appears to be highly effective in the treatment of tinea cruris/corporis when applied once or twice daily and may be very useful in hot and humid conditions where contact irritation reactions occur more often.
Tanenbaum
L
L
Syntex Research, Palo Alto, California.
Taplin
D
D
Lavelle
C
C
Akers
W A
WA
Rosenberg
M J
MJ
Carmargo
G
G
D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003022:Clotrimazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D004311:Double-Blind Method; D004643:Emollients / Q000008:administration & dosage / Q000627:therapeutic use; D004821:Epidermophyton / Q000302:isolation & purification; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D011897:Random Allocation; D014005:Tinea / Q000188:drug therapy*
D000935:Antifungal Agents; D004643:Emollients; D007093:Imidazoles; C033308:sulconazole; D003022:Clotrimazole