title: Low serum progesterone levels and tubal dysfunction--a possible cause of ectopic pregnancy.
abstract: We analyzed 22 human oviducts by the suction electrode method for electrical activity (preceding and reflecting the mechanical activity), as related to serum progesterone levels. Eleven patients had high progesterone levels (greater than or equal to 20 nmol/L), but the other 11 patients had low levels. When the serum progesterone level was low, the oviductal electrophysiologic characteristics were those associated with poor ovum transfer: low probability of prouterine propagation of the activity at the fimbrial end of the tube: high-frequency but low number of electrical bursts, reflecting possible weak propulsive force; and a high occurrence rate of sine-wave-like activity and inactive areas where ovum retention can occur. These phenomena could be related to the higher incidence of ectopic pregnancies in patients with luteal phase defect.
authors: Department of Obstetrics and Gynecology, University of Turku, Finland.
authors: M O
authors: MO
authors: Pulkkinen
authors: U M
authors: UM
authors: Jaakkola
mesh_terms: D000328:Adult; D004594:Electrophysiology; D005187:Fallopian Tubes / Q000503:physiopathology*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000097:blood / Q000209:etiology*; D011374:Progesterone / Q000097:blood*
chemical_list: D011374:Progesterone