[Effect of glycine on liver cytochrome P-450 and severity of experimental food anaphylaxis].
Male guinea pigs, intact and orally sensitized with chick ovalbumin (OVA), having initial bw 250-300 g, received glycine intraperitoneally or orally in a single dose of 100 or 200 mg/kg/day, during 3 days. The specific volume of cytochromes P450 and b5 in the microsomal fraction of the liver, activity of aminopyrine N-demethylase and aniline-p-hydroxylase, severity of food anaphylaxis to OVA and the animals' sensitivity to intravenous histamine LD50 were studied. The inducing effect of glycine on the cytochrome P450 system in the liver was more pronounced in the presensitized animals, that was attended by a decreased severity of food anaphylaxis and by a protective action in respect to histamine LD50. Possible mechanisms of glycine action are considered regarding its participation in metabolic processes.
Krzhechkovskaia
V V
VV
Lysenkova
E M
EM
Malikova
N A
NA
Marokko
I N
IN
Kovalev
I E
IE
D000707:Anaphylaxis / Q000201:enzymology / Q000517:prevention & control*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D005512:Food Hypersensitivity / Q000201:enzymology / Q000517:prevention & control*; D005998:Glycine / Q000627:therapeutic use*; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male
D003577:Cytochrome P-450 Enzyme System; D005998:Glycine
Vliianie glitsina na tsitokhrom P-450 i vyrazhennost' éksperimental'noĭ pishchevoĭ anafilaksii.