[A novel phenotype (CD 4+, Leu 7+) in large granular lymphocyte leukemia: a case report].
We report a case of a 72-year-old man with large granular lymphocyte (LGL) leukemia. Immunophenotypical analysis of the abnormal cells showed the following results: CD 2+, CD 3+, CD 4+, CD 8-, CD 11+, CD 16-, Leu 7+. These cells had natural killer (NK) activity, responded to PHA and recombinant interleukin-2 (rIL-2), and showed neither helper nor suppressor function in B-cell differentiation. Molecular genetical analysis showed monoclonal rearrangement of T-cell receptor beta-chain gene, indicating they are of T-cell origin. These findings provide information on biological characteristics of normal CD 4+, Leu 7+ cells.
Ohno
T
T
Miwa
H
H
Anazawa
H
H
Ikeda
T
T
Kawakami
K
K
Katayama
N
N
Shirakawa
S
S
D000368:Aged; D000943:Antigens, Differentiation / Q000032:analysis*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000473:pathology; D008297:Male; D010641:Phenotype
D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte