Prognosis in childhood rhabdomyosarcoma of the extremity.
From 1970 to 1987, 34 patients younger than 22 years of age with extremity rhabdomyosarcoma were treated at the Memorial Sloan-Kettering Cancer Center (MSKCC). All patients were treated according to protocols consisting of surgery, radiotherapy, and multiple drug chemotherapy. Sixteen of 34 patients survived, and 14 continue to be disease-free; the 5-year survival rate was 44%. A retrospective univariate analysis of data according to the TNM staging system was undertaken. Tumor invasion, regional nodal involvement, distant metastases, and alveolar histologic condition each had a significant impact on survival. However, in multivariate analysis, the stage of disease at diagnosis was the most important predictor of survival outcome.
Ghavimi
F
F
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Mandell
L R
LR
Heller
G
G
Hajdu
S I
SI
Exelby
P
P
D000293:Adolescent; D000328:Adult; D000671:Amputation, Surgical; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005121:Extremities; D005260:Female; D006801:Humans; D007223:Infant; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000401:mortality / Q000473:pathology / Q000556:secondary / Q000628:therapy*