[Influence of HIV infection on hepatitis B virus infection in homosexual patients].
Clinical expression and outcome of hepatis B virus infections associated with human immunodeficiency virus infection (without AIDS) were studied in 17 homosexuals during 23 months. In an attempt to distinguish the respective impacts of homosexuality from that of human immuno-deficiency virus, patient were compared with a population of homosexual males infected by hepatitis B virus alone. The ratio of biochemical evidence of liver cell necrosis (ALAT)/viral replication (DNAp) was significatively decreased (p less than 0.01), despite evidence of severe histological damage in some cases. Two-thirds of patients with HBV replication tolerated HBV infection at the end of follow-up. This tolerance was significatively more common than in homosexuals infected by HBV alone (p less than 0.01), and did not appear to be related to decreased T4 cell count but seemed to correlate with the existence of the AIDS related complex.
Favre
O
O
Unité d'Hépatologie, Hôtel-Dieu, Lyon.
Heyraud
J P
JP
Chossegros
P
P
Retornaz
G
G
Ouzan
D
D
Neyrat
M
M
Trépo
C
C
D000328:Adult; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications*; D006509:Hepatitis B / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006515:Hepatitis B virus / Q000502:physiology; D006716:Homosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014779:Virus Replication
Influence de l'infection à VIH sur l'infection par le virus de l'hépatite B chez les patients homosexuels.