Inhibition of infectivity of human immunodeficiency virus by a novel nucleoside, oxetanocin, and related compounds.
Oxetanocin is a novel nucleoside containing a 4-membered sugar, oxetanosyl-N-glycoside, and adenine. The effects of oxetanocin and related compounds on the infectivity of human immunodeficiency virus (HIV) were examined. They inhibited HIV infectivity in vitro. Allopurinol and mycophenolic acid produced additive anti-HIV effects when added with these compounds.
Seki
J
J
Department of Hygiene, Gumma University School of Medicine, Japan.
Shimada
N
N
Takahashi
K
K
Takita
T
T
Takeuchi
T
T
Hoshino
H
H
D000225:Adenine / Q000031:analogs & derivatives* / Q000032:analysis / Q000494:pharmacology; D000493:Allopurinol / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000494:pharmacology*; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D006678:HIV / Q000187:drug effects / Q000472:pathogenicity*; D006801:Humans; D066298:In Vitro Techniques; D009173:Mycophenolic Acid / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects
D000900:Anti-Bacterial Agents; C051061:oxetanocin; D000493:Allopurinol; D009173:Mycophenolic Acid; D000225:Adenine