[Enzymatic synthesis and immunochemical characterization of conjugated morphine-protein antigens].
Conjugates morphine-protein which are formed in the systems of cytochrome P-450 and horse-radish peroxidase can induce in rabbits synthesis of the specific antibodies to morphine. In the blood of animals immunized with the above mentioned conjugates there are antimorphine-antibodies being constituents on immunochemical complexes with endogenous ligands. Administration to rabbits of the conjugated antigen morphine-microsomes of the rabbit liver causes the development of the reaction of hypersensitivity of delayed type to morphine.
Kovalev
I E
IE
Tomilin
V A
VA
D000818:Animals; D000941:Antigens / Q000276:immunology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006735:Horseradish Peroxidase / Q000378:metabolism; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007114:Immunization; D007120:Immunochemistry; D008862:Microsomes, Liver / Q000201:enzymology; D009020:Morphine / Q000276:immunology* / Q000378:metabolism; D010084:Oxidation-Reduction; D011817:Rabbits
D000941:Antigens; D009020:Morphine; D003577:Cytochrome P-450 Enzyme System; D006735:Horseradish Peroxidase
Fermentativnyĭ sintez i immunokhimicheskaia kharakteristika kon'iugirovannykh antigenov morfin-belok.