Serum vitamin D metabolite concentrations in primary hyperparathyroidism.
Forty-nine patients with primary hyperparathyroidism were examined preoperatively and three months after parathyroid operation for their serum vitamin D metabolites and routine laboratory samples related to calcium metabolism. The preoperative serum 24,25-dihydroxyvitamin D level, mean (SE) was 1.86 (0.22) nmol/l and the postoperative level 5.35 (0.63) nmol/l, the difference being highly significant (P less than 0.001). Serum 1,25-dihydroxyvitamin D levels fell significantly (P less than 0.001) from a preoperative level of 175.5 (17.9) pmol/l to 102.8 (10.1) pmol/l postoperatively. The preoperative 25-hydroxyvitamin D level did not change significantly after surgery. The preoperative serum 24,25-dihydroxyvitamin D level was very low, especially in patients with bone disease while serum parathormone was significantly higher than in patients without bone disease.
Nikkilä
M T
MT
Department of Clinical Sciences, University of Tampere, Finland.
Saaristo
J J
JJ
D000328:Adult; D000368:Aged; D004100:Dihydroxycholecalciferols / Q000097:blood; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000601:surgery; D011184:Postoperative Period; D014807:Vitamin D / Q000097:blood*
D004100:Dihydroxycholecalciferols; D014807:Vitamin D