A note on the genetics of a unilateral senile cataract in mice.
Unilateral cataracts were investigated in 750 day-old BALB/c, C57BL/6 and DBA/2 mice, and the six reciprocal crosses between these strains. This abnormality of the lens appears to be inherited additively in the cross DBA/2xBALB/c (with incomplete penetrance in DBA/2 and F1 mice) but as a completely recessive character in the cross DBA/2xC57BL/6. The mode of inheritance may depend on the genetic background against which this phenotype is expressed, unless this abnormality is inherited as a threshold character. Aged DBA/2 mice may constitute a useful model for senile unilateral cataract, probably caused by early uveitis.
Cohen-Salmon
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Laboratoire Genetique, Neurogenetique et Comportement, U.R.A. 1294 C.N.R.S, Universite Paris V, France.
Lhotellier
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Crusio
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Ward
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D000375:Aging / Q000502:physiology*; D000818:Animals; D002386:Cataract / Q000235:genetics* / Q000473:pathology; D005838:Genotype; D006824:Hybridization, Genetic; D051379:Mice; D008815:Mice, Inbred Strains; D013223:Statistics as Topic