[The effect of histamine on the tonus of isolated coronary arteries with intact and damaged endothelium].
In isolated rings of the pig coronary arteries mechanical damage of endothelium led to a considerable reduction of coronary spastic responses to histamine due to the H1-receptors damage after the denudation of endothelium. The tachyphylaxis to histamine was eliminated after de-endothelialization. The drugs blocking H1-receptors such as dimedrol, were effective for preventing the histamine coronary vasospasm.
Karachentsev
A N
AN
Baranov
A G
AG
D000818:Animals; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000503:physiopathology; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology; D004155:Diphenhydramine / Q000494:pharmacology; D004347:Drug Interactions; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects* / Q000502:physiology
D006632:Histamine; D004155:Diphenhydramine
Vliianie gistamina na tonus izolirovannykh koronarnykh arteriĭ s intaktnym i povrezhdennym éndoteliem.