title: Complete Clq deficiency associated with IgG multiple myeloma.
abstract: We report a case of IgG multiple myeloma with selective complete Clq deficiency. The patient was a 75-year-old Japanese woman who exhibited urticaria on the arm and an absence of serum hemolytic complement activity (CH50). Further studies revealed no vasculitis in the urticarial lesion but showed selective complete deficiency of Clq without low molecular weight Clq precipitin. Addition of highly purified Clq restored the CH50 level of the patient's serum to normal. It is suggested that this abnormality was a primary Clq deficiency. We discussed a relationship between the Clq deficiency and myeloma and reviewed the literature.
authors: Department of Internal Medicine, Kawasaki Hospital, Kawasaki Medical School, Okayama, Japan.
authors: S
authors: S
authors: Tokumitsu
authors: Y
authors: Y
authors: Furuta
authors: T
authors: T
authors: Kobayashi
authors: T
authors: T
authors: Amano
authors: S
authors: S
authors: Suzuki
authors: Z
authors: Z
authors: Ota
mesh_terms: D000368:Aged; D003166:Complement Activating Enzymes / Q000172:deficiency*; D003172:Complement C1 / Q000172:deficiency*; D015922:Complement C1q; D003165:Complement System Proteins / Q000172:deficiency; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D009101:Multiple Myeloma / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism*
chemical_list: D003172:Complement C1; D007074:Immunoglobulin G; D015922:Complement C1q; D003165:Complement System Proteins; D003166:Complement Activating Enzymes