The effects of aluminium on brain gangliosides in uraemic rats treated with 24R,25-dihydroxyvitamin D3.
The administration of aluminium to uraemic rats leads to aluminium accumulation in different brain regions. Aluminium intoxication significantly alters brain gangliosides, the content of which is increased in uraemic animals. This phenomenon can be prevented by administration of 24R,25-dihydroxyvitamin D3 (24,25(OH)2D3). Our results could possibly find an application in the prevention of aluminium-induced encephalopathy in patients on haemodialysis.
Vukicević
S
S
Department of Anatomy, School of Medicine, University of Zagreb, Yugoslavia.
Kracun
I
I
Stavljenić
A
A
Kelović
Z
Z
Krempien
B
B
Rösner
H
H
D015650:24,25-Dihydroxyvitamin D 3; D000535:Aluminum / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000378:metabolism; D004100:Dihydroxycholecalciferols / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005732:Gangliosides / Q000378:metabolism*; D051381:Rats; D014511:Uremia / Q000378:metabolism*
D004100:Dihydroxycholecalciferols; D005732:Gangliosides; D015650:24,25-Dihydroxyvitamin D 3; D000535:Aluminum