Seizures after liver transplantation: a clinicopathologic study.
We reviewed the clinical and neuropathologic findings in 21 patients who had seizures after orthotopic liver transplants. Tonic-clonic seizures were the most common seizure type. Six patients developed status epilepticus. In 9 patients, seizures occurred within 1 week following transplantation. We found CNS lesions that were probably responsible for the occurrence of seizures in most patients; some had more than 1 finding. Neuropathologic examination revealed ischemic or hemorrhagic strokes in 18 patients, central pontine myelinolysis in 5, and CNS infections in 5. Multiple metabolic abnormalities were a contributing factor to the onset of seizures in some patients.
Estol
C J
CJ
Department of Neurology, Presbyterian-University Hospital, University of Pittsburgh School of Medicine, PA.
Lopez
O
O
Brenner
R P
RP
Martinez
A J
AJ
D000328:Adult; D002490:Central Nervous System / Q000473:pathology; D002493:Central Nervous System Diseases / Q000150:complications; D004569:Electroencephalography; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology