[Clinical evaluation of cefteram pivoxil in the pediatric field].
Cefteram pivoxil (CFTM-PI, T-2588), a new oral cephalosporin antibiotic, was evaluated for its safety and efficacy in children. Fifty-three patients with bacterial infections were treated with 8.3 to 21.8 mg/kg/day of CFTM-PI. The drug was very effective (efficacy rate 98.1%) in pharyngitis, otitis media, tracheobronchitis, pneumonia and skin infections. The antibacterial potency was very good against Haemophilus influenzae, Streptococcus pyogenes and Streptococcus pneumoniae, and was comparable with cephalexin against Staphylococcus aureus. No severe adverse reaction was encountered with the CFTM-PI therapy. The data suggest that CFTM-PI is a safe and effective antibiotic when used in children with susceptible bacterial infections.
Meguro
H
H
Department of Pediatrics, School of Medicine, Teikyo University.
Arimasu
O
O
Tajima
T
T
Shiraishi
H
H
Kobayashi
M
M
Abe
T
T
D000293:Adolescent; D001424:Bacterial Infections / Q000188:drug therapy*; D015281:Cefmenoxime / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests
C046817:cefteram pivoxil; D015281:Cefmenoxime