[Quantitative DNA analysis in epithelial ovarian cancer].
The tumor cell nuclear DNA content was measured in 27 cases of epithelial ovarian cancer. The proliferative activity of the tumor was correlated with the prognosis of the patients. The proportion of G0 and G1 cells of the tumors of the same histologic type varied among individuals. There was a close relationship between the proliferative activity of the tumor and the remission rate, duration of survival and mortality of the patients. The heterogeneity of the proliferative activity of the tumor cells may explain the difference of response to chemotherapy. It is suggested that the quantitative analysis of DNA content may be used as an theoretical and experimental basis for the individualization of treatment.
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D002453:Cell Cycle; D003536:Cystadenocarcinoma / Q000032:analysis*; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000032:analysis*; D013053:Spectrophotometry
D004273:DNA, Neoplasm