[Prediction of dysbiotic effect in toxico-hygienic assessment of antibiotics].
The results of the studies showed that there was relation between the changes in the size of the typhlon and the composition of the microflora of its contents under antibiotic effect. On the basis of the analysis of the literature data and the experimental results a new toxicometric index i. e. a typhlon weight coefficient was proposed. A procedure for probabilistic estimation of the index is described. Close coincidence of the values of the threshold concentrations determined by the typhlon weight coefficient and the bacteriological methods was observed.
Zel'tser
I Z
IZ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002432:Cecum / Q000187:drug effects* / Q000382:microbiology; D005839:Gentamicins / Q000009:adverse effects; D008034:Lincomycin / Q000009:adverse effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D012293:Rifampin / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D008034:Lincomycin; D012293:Rifampin
O prognozirovanii disbioticheskogo éffekta pri toksiko- gigienicheskoĭ otsenke antibiotikov.