The effect of indomethacin on cartilage breakdown.
The effects of recombinant interleukin-1 alpha (rIL-1 alpha) and indomethacin on the glycosaminoglycan (GAG) content of rat femoral head cartilage (FHC) were studied in vitro. Net GAG loss was observed from cartilage cultured in the presence of indomethacin plus rIL-1 alpha. Indomethacin and rIL-1 alpha alone caused no net loss of GAG from cartilage unless the cartilage was cultured in the presence of fibroblasts.
Desa
F M
FM
Department of Experimental Pathology, St. Bartholomew's Hospital, Medical College, London, UK.
Chander
C L
CL
Moore
A R
AR
Howat
D W
DW
Corry
D G
DG
Willoughby
D A
DA
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D002356:Cartilage / Q000378:metabolism*; D015232:Dinoprostone / Q000096:biosynthesis / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology*; D007375:Interleukin-1 / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D006025:Glycosaminoglycans; D007375:Interleukin-1; D015232:Dinoprostone; D007213:Indomethacin