Ocular injection of retinal S antigen: suppression of autoimmune uveitis.
Uveoretinitis induced in Lewis rats by foot pad injections of retinal soluble (S) antigen is a model system used to study the immunopathogenesis of the autoimmune uveoretinitides in which delayed hypersensitivity plays a dominant role. Since down-regulation of delayed hypersensitivity can be achieved by injection of antigens into the anterior chamber of the eye, we have examined the potential of intracameral S antigen to mitigate experimental autoimmune uveitis. The results of these studies reveal that pretreatment of Lewis rats with S antigen injected into the anterior chamber markedly reduces the incidence and expression of experimental autoimmune uveitis.
Mizuno
K
K
Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101.
Clark
A F
AF
Streilein
J W
JW
D000818:Animals; D000867:Anterior Chamber; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology*; D019393:Arrestin; D001327:Autoimmune Diseases / Q000276:immunology* / Q000517:prevention & control; D005136:Eye Proteins / Q000008:administration & dosage / Q000276:immunology*; D005260:Female; D007267:Injections; D051381:Rats; D011917:Rats, Inbred Lew; D012173:Retinitis / Q000276:immunology; D014605:Uveitis / Q000276:immunology* / Q000517:prevention & control
D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins