Human platelets involvement in immune modulation of graft rejection in mice.
A cell lysate consisting of human thrombocytes is able after a unique i.p. application in mice to prolonge significantly the survival time of skin allografts. A linear relation is existing between the dosis and the effect within a defined dosis area (100 to 300 x 10(6) Gpt). The correlation was proved by the application of cell lysates from 12 single donors (r = 0.575, P less than 0.05) as well as by the application of 5 differently diluted preparations produced from a concentrated total pool (r = 0.577). The fact is discussed that the protective clinical transplant effects occurring by pre-operatively administered blood transfusions may be due to the same principle of action.
Bundschuh
G
G
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D001803:Blood Transfusion; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D017713:Platelet Transfusion; D016038:Skin Transplantation