Percutaneous absorption of 3 organic solvents in the guinea pig. (III). Effect of barrier creams.
The efficacy of 4 barrier preparations presented as cream or foam against percutaneous absorption of organic solvents was investigated in the guinea pig. An ordinary hand cream was also tested. Slight reduction in blood concentration of the solvents was seen when normal skin treated with barrier creams was exposed. Absorption of butanol through stripped skin treated with barrier creams was higher than absorption through skin not so treated. Barrier creams can be considered to give poor skin protection against the organic solvents investigated.
Boman
A
A
Department of Occupational Dermatology, National Institute of Occupational Health, Solna, Sweden.
Mellström
G
G
D000818:Animals; D000440:Butanols / Q000378:metabolism*; D006168:Guinea Pigs; D006843:Hydrocarbons, Chlorinated / Q000378:metabolism*; D009824:Ointments / Q000627:therapeutic use; D012869:Skin Absorption / Q000187:drug effects; D012997:Solvents / Q000378:metabolism; D013997:Time Factors; D014050:Toluene / Q000378:metabolism*
D000440:Butanols; D006843:Hydrocarbons, Chlorinated; D009824:Ointments; D012997:Solvents; D014050:Toluene