Immunohistochemical study of peripolar cells of the sheep.
The proposal that the cytoplasmic granules of glomerular peripolar cells (PPCs) of the adult sheep and lamb contain a kallikrein-like substance has been re-examined. After extensive characterisation and purification of anti-kallikrein antibodies, it was concluded that PPCs do not contain immunohistochemically detectable amounts of urinary kallikrein; nor do such cells appear to synthesise kallikrein as shown by hybridisation histochemistry studies. They are also not renin-immunopositive. On the other hand, a proportion of them exhibit neuron-specific enolase (NSE) immunoreactivity, unlike the apparently closely related visceral and parietal epithelial cells.
Trahair
J F
JF
Department of Anatomy, University of Melbourne, Parkville, Victoria, Australia.
Gall
J A
JA
Alcorn
D
D
Coghlan
J P
JP
Fernley
R
R
Penschow
J
J
Grattage
L P
LP
Johnston
C I
CI
Ryan
G B
GB
D000818:Animals; D003594:Cytoplasmic Granules / Q000032:analysis; D007150:Immunohistochemistry; D007610:Kallikreins / Q000032:analysis*; D007668:Kidney / Q000032:analysis* / Q000166:cytology; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D012756:Sheep
D007610:Kallikreins; D010751:Phosphopyruvate Hydratase