Experimental studies on complete global brain ischemia using the isohistogenic infantile head transplant model in Lewis rats.
A new experimental model is presented, using isohistogenic Lewis rats and microsurgical techniques. Transplantation of the head and forelimbs of the infantile rat was done to the groin of an adult rat. The goal was to study the effects of ischemia on brain tissue. This model also proved useful for other experiments in studies of facial and cranial bone growth. The model presented proved efficient for the study goals, and long-term experiments were possible. The maximum ischemia time tolerated by brain tissue was found to be somewhere between 60 min and 120 min.
Sakurai
A
A
Department of Plastic and Reconstructive Surgery, Faculty of Medicine, University of Tokyo, Japan.
Hirabayashi
S
S
Harii
K
K
Fukuda
O
O
D000818:Animals; D001921:Brain / Q000473:pathology*; D002545:Brain Ischemia / Q000209:etiology* / Q000473:pathology; D002560:Cerebrovascular Circulation; D004569:Electroencephalography; D006257:Head / Q000637:transplantation*; D008866:Microsurgery / Q000379:methods; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors