Mesocolic myxoid hamartoma showing neural differentiation: an ultrastructural and immunohistochemical study.
A myxoid mesocolic tumor in a 4-month-old female infant is described. The tumor weighed 190 g and measured 8 cm in diameter and presented as a single mass composed of stellate and round cells with vesicular nuclei and prominent nucleoli in a myxoid, well-vascularized stroma. Electron microscopy showed mesenchymal cells with dilated rough endoplasmic reticulum, cell projections with primitive and desmosome-like cell junctions, and basal membrane-like material. Immunohistochemical studies demonstrated immunoreactivity with antibodies against vimentin and S-100 protein. The infant is well and without evidence of disease 3 years after surgery. This is an example of a peripheral myxoid hamartoma with neural differentiation, and the tumor is expected to have a benign clinical course.
Henriquez
A
A
Department of Pediatric Pathology, Hospital Luis Calvo Mackenna, Santiago de Chile.
Latorre
J J
JJ
Gonzalez
S
S
D005260:Female; D006222:Hamartoma / Q000378:metabolism / Q000601:surgery / Q000648:ultrastructure*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008646:Mesocolon; D008854:Microscopy, Electron; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure; D010534:Peritoneal Neoplasms / Q000378:metabolism / Q000601:surgery / Q000648:ultrastructure*; D009418:S100 Proteins / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
D009418:S100 Proteins; D014746:Vimentin