title: Effects of propofol on baroreflex control of heart rate and on plasma noradrenaline levels.
abstract: The effects of propofol induction (2.5 mg kg-1) and of two continuous infusion rates of propofol (100 and 200 micrograms kg-1 min-1) on baroreflex control of heart rate and on plasma noradrenaline concentration were investigated in 11 unpremedicated patients. Baroreflex function was assessed using a pressor test (phenylephrine) and a depressor test (sodium nitroprusside). In addition, samples for subsequent determination of plasma noradrenaline levels and blood propofol levels were collected before each test. Baroreflex sensitivity and plasma noradrenaline concentrations were not significantly changed at any time of the study. By contrast, a significant and sustained resetting of baroreflex set point was observed, allowing unchanged heart rate at lower arterial pressure. It is concluded that the effects of propofol on baroreflex function and noradrenaline concentration are moderate.
authors: Département d'Anesthésie et de Réanimation Chirurgicale, Hôpital Bichat, Paris, France.
authors: E
authors: E
authors: Samain
authors: J
authors: J
authors: Marty
authors: R
authors: R
authors: Gauzit
authors: I
authors: I
authors: Bouyer
authors: E
authors: E
authors: Couderc
authors: R
authors: R
authors: Farinotti
authors: J M
authors: JM
authors: Desmonts
mesh_terms: D000328:Adult; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D011311:Pressoreceptors / Q000187:drug effects* / Q000502:physiology; D015742:Propofol / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects* / Q000502:physiology
chemical_list: D009638:Norepinephrine; D015742:Propofol