Site-specific drug delivery to CNS: old and new.
Delivery of drugs to specific sites in the CNS represents an essential therapeutic challenge. Extradural administration of opiates successfully delivers drugs to the CNS. The levodopa-carbidopa combination achieved some degree of site-specific delivery by pharmacological methods. Antibiotics have been administered through cannula directly into ventricles. Invasive methods offer the greatest degree of site-specificity.
Hollister
L E
LE
University of Texas Medical School, Houston.
D000544:Alzheimer Disease / Q000188:drug therapy*; D001927:Brain Diseases / Q000188:drug therapy* / Q000601:surgery; D004333:Drug Administration Routes; D006801:Humans; D009417:Nerve Tissue / Q000637:transplantation