[Prevention of acute neonatal respiratory insufficiency. A method of conditioning the baboon lung during cesarean section].
Preterm baboons at 140 +/- 3 day gestation (term 182 +/- 7 days) have been subjected to lung conditioning, consisting of a series of prolonged inflations of the lungs at 35 cm H2O, followed by approximately 10 min of application of continuous positive airway pressure (CPAP) equal to 15-20 cm H2O, before umbilical cord interruption. The aim of this study was to evaluate, in a primate experimental model, the safety and efficacy in the prevention of neonatal RDS of a technique so far experimented on only in ovine models. Thoraco-pulmonary compliance exceeded the value of 0.2 ml (cm H2O)-1.kg-1 in only 1 animal out of 5 (20%), which didn't develop illness, versus 69% of positive results achieved with the same technique in lambs at 128-130 day gestation, an experimental model considered in the literature as equivalent to a 140 +/- 3 day gestation baboon as far as it concerns incidence and severity of RDS. The application of lung conditioning was easy and safe (as previously reported), but its effectiveness in a primate model is still to be defined.
Solca
M
M
Frigerio
L
L
Farina
C
C
Marini
A
A
Pifarotti
G
G
Ferrari
A
A
Candiani
G B
GB
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002585:Cesarean Section; D004195:Disease Models, Animal; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000503:physiopathology*; D010215:Papio; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology / Q000517:prevention & control*
La prevenzione dell'insufficienza respiratoria acuta neonatale. Metodica di condizionamento del polmone del babbuino in corso di taglio cesareo.