title: [In vivo bactericidal effect of ciprofloxacin, ofloxacin and pefloxacin against Staphylococcus aureus].
abstract: The bactericidal activity of ciprofloxacin, ofloxacin, pefloxacin, against methicillin sensitive S. aureus (2 different strains) was studied on a model of infected fibrin clots inserted subcutaneously in rabbit. The quinolones were delivered intravenously, as a single daily dose of 100 mg/kg/day. The bactericidal activity was evaluated by determining for various time points (1 h, 2 h, 6 h, 12 h, and 24 h after the infusion of the antibiotics), viable organisms in the dissolved clots. This study shows that: 1) No significant difference appears between the quinolones studied. 2) The in vivo early bactericidal activity of quinolones against S. aureus appears to be better than oxacillin but lesser than oxacillin-netilmicin combination.
authors: Service des Maladies Infectieuses, Centre Hospitalier Universitaire Nancy-Brabois, Vandoeuvre-Lès-Nancy.
authors: H
authors: H
authors: Tronel
authors: P
authors: P
authors: Voiriot
authors: M
authors: M
authors: Weber
authors: C
authors: C
authors: Dopff
authors: P
authors: P
authors: Dewachter
authors: F
authors: F
authors: Phelisse
authors: J B
authors: JB
authors: Dureux
mesh_terms: D000818:Animals; D002939:Ciprofloxacin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology*; D015366:Pefloxacin / Q000494:pharmacology*; D011817:Rabbits; D013203:Staphylococcal Infections; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D015366:Pefloxacin; D002939:Ciprofloxacin; D015242:Ofloxacin
vernacular_title: Etude de l'activité bactéricide in vivo de la ciprofloxacine, de l'ofloxacine et de la péfloxacine vis-à-vis de Staphylococcus aureus.