Dose-related effects of ZnCl2 on dental plaque formation and plaque acidogenicity in vivo.
The plaque-inhibiting capacity of 5-, 10-, 20-, and 100-mM ZnCl2 solutions was examined in 10 dental hygienist students. Twice daily mouthrinses with a 10-ml solution of 5, 10, and 20 mM ZnCl2 significantly inhibited plaque formation (p less than or equal to 0.05), whereas 100 mM ZnCl2 had only a negligible effect. Mouthrinses with 5 and 100 mM ZnCl2 were also tested in 6 dental students characterized as being heavy plaque formers. In this group, the antiplaque effect of 5 mM ZnCl2 was more pronounced, while 100 m ZnCl2 also significantly decreased plaque accumulation. The effect of a single mouthrinse with a 10-ml solution of 5 and 100 mM ZnCl2 on plaque acidogenicity was also assessed in 5 dental students. 5mM ZnCl2 significantly depressed acid production by plaque 30 min after a rinse, while 100 mM ZnCl2 inhibited acid production significantly for up to 4 h. 100 mM ZnCl2 was significantly more effective at depressing acid production than 5 mM ZnCl2 30 min after a rinse.
Giertsen
E
E
Dental Faculty, University of Oslo, Norway.
Scheie
A A
AA
Rölla
G
G
D000143:Acids / Q000378:metabolism; D002712:Chlorides / Q000008:administration & dosage / Q000627:therapeutic use*; D003773:Dental Plaque / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D003774:Dental Plaque Index; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009067:Mouthwashes; D010919:Placebos; D015032:Zinc / Q000008:administration & dosage / Q000627:therapeutic use*; D017967:Zinc Compounds
D000143:Acids; D002712:Chlorides; D009067:Mouthwashes; D010919:Placebos; D017967:Zinc Compounds; C016837:zinc chloride; D015032:Zinc