Inhibition of HIV-1 replication and syncytium formation by synthetic CD4 peptides.
Only one peptide of CD4 (amino acid residues 70-132) among 16 synthetic peptide fragments selectively inhibited HIV-1 replication and HIV-1-induced syncytium formation. Several smaller peptides within this region did not show any activity, except for the peptide (86-132) which showed somewhat lower activity.
Hayashi
Y
Y
Department of Pathology, Osaka University, Japan.
Ikuta
K
K
Fujii
N
N
Ezawa
K
K
Kato
S
S
D000945:Antigens, Differentiation, T-Lymphocyte / Q000138:chemical synthesis / Q000494:pharmacology*; D002478:Cells, Cultured; D004306:Dose-Response Relationship, Immunologic; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000494:pharmacology; D014612:Vaccines / Q000494:pharmacology*; D014614:Vaccines, Synthetic / Q000494:pharmacology*; D014765:Viral Vaccines / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
D000945:Antigens, Differentiation, T-Lymphocyte; D010446:Peptide Fragments; D014612:Vaccines; D014614:Vaccines, Synthetic; D014765:Viral Vaccines