Correlation of bone marrow colony growth in the myelodysplastic syndromes with the FAB classification and the Bournemouth score.
Erythroid and myeloid colonies were grown from the bone marrow of 81 patients with myelodysplasia and the median number of colonies correlated with the FAB classification and Bournemouth score. CFU-GM were increased in CMML compared to RAEB and RAEBt. BFU-E were higher in RA than in the other FAB subgroups. Patients with a high Bournemouth score had poorer CFU-GM and BFU-E growth than those with a low score.
Oscier
D G
DG
Department of Haematology, Royal Victoria Hospital, Bournemouth, U.K.
Worsley
A
A
Darlow
S
S
Figes
A
A
Williams
J D
JD
Hamblin
T J
TJ
D000753:Anemia, Refractory / Q000473:pathology; D000754:Anemia, Refractory, with Excess of Blasts / Q000473:pathology; D000756:Anemia, Sideroblastic / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology*; D003114:Colony-Forming Units Assay; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000145:classification / Q000473:pathology*