[An immune adjuvant activity of mycolic acid-containing glycolipid, trehalose-2,3,6'-trimycolate, derived from Gordona aurantiaca].
A mycolic acid-containing glycolipid, trehalose-2,3,6'-trimycolate (GaGM), derived from Gordona aurantiaca, an acid-fast bacterium closely related taxonomically to Mycobacterium, was investigated for its immune adjuvant activity on cell-mediated responses in the mouse. I.V. injection of liposomes containing GaGM enhanced the generation of cytotoxic T-lymphocyte (CTL) against syngeneic and allogeneic tumor cells. In addition, the injection of GaGM augmented the natural killer (NK) activity and the antibody-dependent cellular cytotoxicity (ADCC). These results suggest that the injection of GaGM induces the production of interleukin-2 (IL-2), since such effector cells as CTL, NK and K cells have been shown to require IL-2 for their development.
Ohtsubo
Y
Y
Furukawa
M
M
Fujinobu
Y
Y
Sugimoto
N
N
Ikutoh
M
M
Katoh
Y
Y
Yano
I
I
Higasa
M
M
Shinka
S
S
Dohi
Y
Y
D000276:Adjuvants, Immunologic; D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects; D002478:Cells, Cultured; D006017:Glycolipids / Q000302:isolation & purification / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D009161:Mycobacterium / Q000032:analysis*
D000276:Adjuvants, Immunologic; D006017:Glycolipids; D007376:Interleukin-2; C060019:trehalose 2,3,6'-trimycolate