[Effect of x-ray contrast substances on the complement system of rats].
The purpose of the work was to demonstrate the effect of radiographic contrast media (RCM) 50% bilignost, 76% triombrast, 80% iodamide-380 on the complement system in rats. It has been found that RCM cause alternative complement activation during incubation with the whole blood or serum in vivo and in vitro. The RCM effect value depends on the drug dose and increase in the order: triombrast iodamide bilignost. Different sensitivity of animals to the effect of RCM on the complement system has been shown.
Sergeev
P V
PV
Kul'berg
A Ia
AIa
Shimanovskiĭ
N L
NL
Napolov
Iu K
IuK
Ukhanov
S V
SV
D000818:Animals; D003167:Complement Activation; D003170:Complement Pathway, Alternative / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006461:Hemolysis / Q000187:drug effects; D066298:In Vitro Techniques; D007451:Iodamide / Q000494:pharmacology; D007458:Iodipamide / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D003287:Contrast Media; D003974:Diatrizoate Meglumine; D007451:Iodamide; D007458:Iodipamide
Vliianie rentgenokontrastnykh sredstv na sistemu komplementa u krys.