title: In vitro polymorphonuclear neutrophil function in surgical patients does not correlate with anergy but with "activating" processes such as sepsis or trauma.
abstract: We studied 199 preoperative patients admitted for esophagogastric, gastric, colonic, or rectal resections, 132 patients with severe blunt trauma, 180 surgical intensive care unit patients with major sepsis, and 95 laboratory controls in order to clarify the role of polymorphonuclear neutrophil (PMN) adherence and chemotaxis to outcome. Patients were also stratified by the delayed-type hypersensitivity response to five ubiquitous antigens. PMN adherence and PMN chemotaxis were not different in preoperative reactive or anergic patients and were equal to the control values, whereas both reactive patients and anergic patients showed altered PMN function after trauma or sepsis. There was no difference in PMN adherence or chemotaxis between patients who died and those who lived. Multiple logistic regression analysis showed that patient age, delayed-type hypersensitivity, and admission serum albumin level, not PMN adherence or chemotaxis, were significantly related to septic mortality. We concluded that altered circulating PMN adherence and chemotaxis is seen in all patients after an "activation" event such as trauma or sepsis. This is a nonspecific immune alteration not related to specific immune events such as delayed-type hypersensitivity; it does not correlate with patient outcome and should not be used as a predictive variable.
authors: Department of Surgery McGill University, Montreal, Quebec, Canada.
authors: N V
authors: NV
authors: Christou
authors: J M
authors: JM
authors: Tellado
mesh_terms: D000328:Adult; D000368:Aged; D001247:Asthenia / Q000503:physiopathology*; D002448:Cell Adhesion; D002634:Chemotaxis, Leukocyte; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000503:physiopathology*; D007239:Infections / Q000503:physiopathology*; D008297:Male; D009026:Mortality; D009504:Neutrophils / Q000502:physiology*; D012044:Regression Analysis; D014947:Wounds and Injuries / Q000503:physiopathology*