Neuropsychological correlates of subclinical paroxysmal EEG activity in children with epilepsy. 1: Qualitative features (generalized and focal abnormalities).
The cognitive deficit often associated with epilepsy is attributable to the presence and interaction of several factors but whether recurrent subclinical spike-wave discharges interfere with cognitive development is not yet clear. In the present study, the presence of subclinical discharges proved to be significantly associated with lower than average Full-Scale Intelligence Quotient (IQ), Verbal IQ and Performance IQ scores (Wechsler Intelligence Scale for Children) in comparison with patients not presenting EEG abnormalities during test. These findings confirm the adverse effect both of generalized and focal EEG epileptiform abnormalities, even if unaccompanied by overt seizures.
Brinciotti
M
M
Institute of child neuropsychiatry, La Sapienza University, Rome, Italy.
Matricardi
M
M
Paolella
A
A
Porro
G
G
Benedetti
P
P
D000293:Adolescent; D000328:Adult; D002648:Child; D003072:Cognition Disorders / Q000209:etiology*; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008297:Male