[Possibility of lowering the dose of metronidazole during the irradiation of tumors using subsequent artificial hyperglycemia].
The therapeutic efficacy of a scheme of poly-radiomodification with metronidazole (MZ) administration was investigated in experiments on mice with Ehrlich carcinoma before local irradiation of tumors and with subsequent induced hyperglycemia (IH) depending on a MZ dose. For equally effective potentiation of the effect of radiation on a tumor during a combined use of MZ and postradiation IH a 4-fold lower dose of the drug was required as combined to MZ used alone. The combined effect of the modifiers was superadditive. The use of IH in this scheme not only potentiated skin radiation reactions on a tumor growth zone but also slightly weakened their expression.
Vinskaia
N P
NP
Voloshina
E A
EA
Kozin
S V
SV
D000818:Animals; D001786:Blood Glucose / Q000502:physiology*; D002286:Carcinoma, Ehrlich Tumor / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage* / Q000627:therapeutic use; D051379:Mice; D009368:Neoplasm Transplantation; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage* / Q000627:therapeutic use
D001786:Blood Glucose; D011838:Radiation-Sensitizing Agents; D008795:Metronidazole
Vozmozhnost' snizheniia dozy metronidazola pri obluchenii opukholeĭ sposleduiushcheĭ iskusstvenoĭ giperglikemieĭ.