[Experimental studies on vascularized allogeneic joint grafts].
Vascularized joint transplantations and limb transplantations were performed on inbred rats on five different strains to investigate (i) the effect of vascularity on the joint graft, and (ii) the influence of subregions of the rat major histocompatibility antigen (RTI) on the allogeneic joint graft. According to roentgenograms and histological findings of autogenous joint grafts, the bone healing was prompt and the joint structure was well preserved in the vascularized grafts compared to the non-vascularized grafts. 99m Tc-MDP scintigrams and the histological study of the allogeneic graft, indicated that transplanted limbs of which subregions of RT1 were partially matched in particular those RT1-A were matched, remained alive longer than limbs of which subregions were completely different. This study suggests that the success of the allogeneic joint transplantation might be dependent on the vascularity and low antigenicity between the donor and the recipient.
Sakuma
T
T
Department of Orthopaedic Surgery, School of Medicine, Hokkaido University, Sapporo, Japan.
D000818:Animals; D005121:Extremities / Q000000981:diagnostic imaging / Q000637:transplantation*; D007596:Joints / Q000098:blood supply*; D008285:Major Histocompatibility Complex / Q000276:immunology; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013669:Technetium Tc 99m Medronate; D014181:Transplantation Immunology
D013669:Technetium Tc 99m Medronate