title: Human BF*F-subtypes: segregation analysis with inclusion of MHC haplotypes.
abstract: The segregation of factor B(BF)F subtypes was analyzed in conjunction with other MHC markers in 15 families with 89 offspring. Informative data for BF F subtypes were obtained from 11 families, 6 of them with known recombinant individuals for the HLA-B/DR/GLO region. The subtypes did not contribute further to the localization of the cross-overs, but followed the known segregation of conventional BF allotypes. In 2 families of one kinship, the recognition of heterozygous BF*FAFB individuals could be established following the inclusion of three generations. The rarer of the two BF F subtype alleles, BF*FA, is positively associated with the HLA haplotypes BW62, CW3, C4A*3 and A29, CWX, B44, C4A*3, B*1, DR7. BF F subtypes are regarded as a very useful additional tool for studies of MHC organization and disease association.
authors: Institut für Gerichtliche Medizin der Humboldt-Universität, Berlin, German Democratic Republic.
authors: G
authors: G
authors: Geserick
authors: G
authors: G
authors: Mauff
authors: I
authors: I
authors: Siemens
authors: H
authors: H
authors: Waltz
authors: A
authors: A
authors: Mayer
authors: K
authors: K
authors: Bender
authors: M
authors: M
authors: Rose
authors: S
authors: S
authors: Goldmann
authors: M
authors: M
authors: Brenden
authors: H
authors: H
authors: Schröder
mesh_terms: D000483:Alleles; D011415:Complement Factor B / Q000235:genetics*; D004792:Enzyme Precursors / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic
chemical_list: D004792:Enzyme Precursors; D005819:Genetic Markers; D006680:HLA Antigens; D011415:Complement Factor B