title: Rapid headspace gas chromatographic method for the determination of liquid/gas partition coefficients.
abstract: A rapid, efficient and low-cost headspace technique useful for the determination of liquid/gas partition coefficients of gases and volatile substances of low and intermediate solubility is described. The equilibration step is carried out at constant pressure using glass syringes, with a ratio of liquid/gas phase volumes of ca. 1:3; after 30 min at the desired temperature, the headspace is recovered by transfer into another syringe and analyzed by gas chromatography. A study of the partition coefficients in water at 37 degrees C of 27 volatile compounds demonstrated that the method is fully applicable for all gases, with exception of those with a partition coefficient higher than 300.
authors: Department of Pharmacology, Autonomous University of Barcelona, Spain.
authors: R
authors: R
authors: Guitart
authors: A
authors: A
authors: Puigdemont
authors: M
authors: M
authors: Arboix
mesh_terms: D002849:Chromatography, Gas / Q000379:methods*; D005740:Gases / Q000032:analysis; D008433:Mathematics; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011312:Pressure; D012995:Solubility; D013696:Temperature; D014835:Volatilization; D014867:Water
chemical_list: D005740:Gases; D004364:Pharmaceutical Preparations; D014867:Water