title: DR4 prevalence related to the age at disease onset in female patients with rheumatoid arthritis.
abstract: The prevalence of HLA-DR4 in relation to age at disease onset was calculated in 226 consecutive female patients with definite or classical rheumatoid arthritis (RA). A slight increase in the prevalence of DR4 with age at RA onset was found. This appeared to be due to the low percentage of rheumatoid factor (RF) positivity in the youngest age groups; the DR4 prevalence in the RF positive patients was constant for all decades--that is, approximately 60%. A previously reported declining trend of DR4 prevalence in women with RA in relation to age of RA onset may be due to the disease heterogeneity of the patients included in that study.
authors: Department of Rheumatology, University Hospital Leiden, The Netherlands.
authors: J M
authors: JM
authors: Hazes
authors: B A
authors: BA
authors: Dijkmans
authors: J M
authors: JM
authors: Hoevers
authors: J J
authors: JJ
authors: Janson
authors: R R
authors: RR
authors: de Vries
authors: J P
authors: JP
authors: Vandenbroucke
authors: A
authors: A
authors: Cats
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis*; D015804:HLA-DR4 Antigen; D006801:Humans; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000032:analysis
chemical_list: D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; D012217:Rheumatoid Factor