IgE antibodies to human growth hormone prior to and during treatment.
Clinical manifestations of allergy to biosynthetic hGH were not reported in 245 patients treated for one year. A sensitive radioallergosorbent test showed, however, the presence of anti-hGH IgE antibodies in the sera of 13%. All patients with anti-hGH IgE had also elevated concentrations of total serum IgE, similar to atopic persons (2459 +/- 147 micrograms/l, normal 70 +/- 8, 2p less than 0.0001); 83% of all patients who had specific IgE antibodies to hGH had specific antibodies prior to treatment. Administration of hGH did not consistently change concentrations (up to 8 micrograms/l) or affinities (less than 10(7) to 1.3 X 10(9) l/mol) of the specific reagins. Anti-hGH IgE antibodies were related to atopy. Treatment with biosynthetic hGH did not significantly stimulate specific IgE.
Petersen
K G
KG
Department of Clinical Endocrinology, University Medical Hospital, Freiburg, FRG.
Khalaf
A
A
Zeisel
H J
HJ
Stryjek-Kaminska
D
D
Kerp
L
L
D000293:Adolescent; D000328:Adult; D002648:Child; D004342:Drug Hypersensitivity / Q000276:immunology*; D013006:Growth Hormone / Q000276:immunology* / Q000627:therapeutic use; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D011852:Radioallergosorbent Test
D007073:Immunoglobulin E; D013006:Growth Hormone