The effect of loxiglumide (CR-1505) on basal and bombesin-stimulated gallbladder volume in man.
This study was undertaken in 5 normal subjects to determine the role of cholecystokinin (CCK) in the regulation of basal gallbladder volume and gallbladder contraction stimulated by infusion of bombesin. Administration of the CCK-receptor antagonist, loxiglumide (CR-1505), led to doubling of the gallbladder volume (increase 104 +/- 26%; P less than 0.05) and reduced the bombesin-stimulated gallbladder contraction from 69 +/- 17 to 19 +/- 17% (P less than 0.05). The findings provide evidence suggesting that CCK plays an important role in the regulation of basal gallbladder tone and in mediating the gallbladder contraction induced by the administration of bombesin.
Douglas
B R
BR
Department of Gastroenterology-Hepatology, University Hospital, Leiden, The Netherlands.
Jebbink
M C
MC
Tjon a Tham
R T
RT
Jansen
J B
JB
Lamers
C B
CB
D000328:Adult; D001839:Bombesin / Q000494:pharmacology*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D005260:Female; D005704:Gallbladder / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011377:Proglumide / Q000494:pharmacology / Q000031:analogs & derivatives; D013997:Time Factors
C053737:loxiglumide; D002766:Cholecystokinin; D011377:Proglumide; D001839:Bombesin