title: [A case of localized pleural tuberculosis exacerbated during antituberculous chemotherapy].
abstract: A 24 year-old male with pulmonary tuberculosis in right upper lobe developed two lesions of extrapulmonary pleural tuberculoma during the course of antituberculous therapy. He had no history of lung tuberculosis nor pleurisy. However, the chest X-ray film on first admission showed scattered nodular shadows in right upper lung field. He had no subjective symptoms and no abnormalities of laboratory findings except mild iron deficiency anemia, from which he recovered completely without specific therapy. Three months after starting the antituberculous therapy including SM, INH, and RFP, a new round homogeneous opacity appeared in the right lower lung field (S4). Chest CT scan revealed the lesions in S10 as well as in S4. Microscopic examination of the specimen obtained by ultrasound-guided needle aspiration biopsy disclosed positive acid-fast bacilli. Because of the lack of effect of drug therapy on pleural lesions, surgical treatment was performed. The visceral pleura was found adherent fibrously to parietal pleura, which was easily separated by hand. However, at the site of lesions, the adhesion was so tight that extrapleural resection was needed. Because lung tissue and tumor were connected tightly, the lung had to be partially resected. Most content of tumors were caseous necrosis. Although main lesion was located outside of the lung, intrapulmonary invasion was also noticed. Double lesions of this kind of disease seem to be very rare. There is no evidence of relapse until eight months after surgery.
authors: K
authors: K
authors: Fujieda
authors: T
authors: T
authors: Ito
authors: S
authors: S
authors: Okubo
authors: H
authors: H
authors: Morinari
authors: M
authors: M
authors: Harasawa
authors: S
authors: S
authors: Masuda
authors: K
authors: K
authors: Yakumaru
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D014375:Tuberculoma / Q000473:pathology* / Q000601:surgery; D014396:Tuberculosis, Pleural / Q000473:pathology* / Q000601:surgery; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000995:Antitubercular Agents