[Changes in the sensitivity of the adrenoreactive systems of various subtypes in rheumatic fever in children].
Distinct and generalized decrease in sensitivity of alpha 2-adrenoreactive system, pronounced decrease of beta 1- and beta 2-but not of alpha 1-adrenoreactivity were observed in children with acute rheumatic fever. After cupping of the rheumatic attack and restoration of circulation functions impairments of the alpha 2-adrenoreactivity (but not of beta 1- and beta 2-adrenoreactivities) were decreased however without complete normalization. Absence of a number of sympathogenic reactions appears to occur due to impairment of the adrenoreactive system sensitivity even though accumulation of catecholamines as found in biological fluids, as a result of which catecholamine-effector uncoupling elevated.
Kulinskiĭ
V I
VI
Chesmochakova
E I
EI
D000293:Adolescent; D002395:Catecholamines / Q000378:metabolism*; D002648:Child; D006801:Humans; D011941:Receptors, Adrenergic / Q000502:physiology*; D012216:Rheumatic Diseases / Q000378:metabolism / Q000503:physiopathology*
D002395:Catecholamines; D011941:Receptors, Adrenergic
Izmeneniia chuvstvitel'nosti adrenoreaktivnykh sistem raznykh podtipov pri revmatizme u deteĭ.