Hypersecretion of gonadotropins by a pituitary adenoma: pituitary dynamic studies and treatment with bromocriptine in one patient.
Pituitary adenomas secreting gonadotropins are often diagnosed as nonsecreting tumors on the basis of clinical findings. We now describe a middle-aged woman who developed visual disturbances and was found to have a large infiltrating pituitary adenoma secreting large quantities of follicle-stimulating hormone (FSH) with moderate elevation of luteinizing hormone (LH). The patient twice underwent transsphenoidal microsurgery to partially remove the adenoma. Thereafter, a trial with bromocriptine was initiated. Normal levels of FSH and LH were observed after 6 weeks of treatment as well as improvement of visual field examination. This case illustrates the fact that some gonadotropin-secreting adenomas can be extremely sensitive to dopamine agonist adenomas can be extremely sensitive to dopamine agonist therapy.
Comtois
R
R
Notre-Dame Hospital, University of Montreal, Quebec, Canada.
Bouchard
J
J
Robert
F
F
D000236:Adenoma / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D001971:Bromocriptine / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006062:Gonadotropins / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology
D006062:Gonadotropins; D001971:Bromocriptine