[Optimization of methodology and extension of indications for beta therapy of neoplasms of the eyelids, conjunctiva and cornea].
The paper offers a theoretical foundation and results after clinical approbation of the method developed by the authors for beta therapy by enlarged single doses using, if necessary, a speeded-up fractionating and split courses of radiation. Beta therapy was used in 220 patients with tumors of the eye lids, conjunctiva and cornea, single doses of radiation, 40 Gr daily or each other day. By their morphologic type the tumors were mostly malignant epithelial and pigmented new-formations (sarcoma, melanoma). In the follow-up period, from 1 to 6 years, the following results were recorded: the treatment proved effective for epithelial tumors in 97%, melanocytic--in 73%; recurrences appeared in 3%; the number of postradiation complications made up 6.6%, of them disturbances in visual functions--2%: death from metastases in melanoma--8.7% of cases. The proposed method of radiation allowed to increase indications for beta therapy of this pathology to 5-6 mm of the tumor protrusion, to decrease the number of complications and terms of treatment. As a result of computer analysis of clinical results, a new method for calculation of optimal summary doses of beta radiation was worked out, that can be used by practitioners in conducting beta therapy for tumors of the eye lids, conjunctiva and cornea.
Fokin
V P
VP
Terent'eva
L S
LS
Usov
N I
NI
Karpovskiĭ
E Ia
EIa
D001610:Beta Particles / Q000627:therapeutic use; D003230:Conjunctival Neoplasms / Q000532:radiotherapy*; D003316:Corneal Diseases / Q000532:radiotherapy*; D005142:Eyelid Neoplasms / Q000532:radiotherapy*; D005500:Follow-Up Studies; D006801:Humans; D008722:Methods; D009369:Neoplasms / Q000532:radiotherapy; D011879:Radiotherapy Dosage; D012044:Regression Analysis
Optimizatsiia metodiki i rasshirenie pokazaniĭ dlia beta-terapii pri novoobrazovaniiakh vek, kon''iunktivy i rogovitsy.