Primary association of HLA-DQw8 with type I diabetes in DR4 patients.
DNA from 164 Caucasian type I (insulin-dependent) diabetic patients and 200 Caucasian nondiabetic control blood donors were analyzed by the polymerase chain reaction technique for HLA-DR4 and the associated Dw and DQB subtypes of DR4. The DQw8 subtype of HLA-DR4 was associated with type I diabetes in all DR4 subgroups (DR4/3 and DR4/non-3). Dw subtypes of DR4 other than DW10 did not confer additional association with type I diabetes. Thus, the DQ region appears to provide the primary major histocompatibility association with type I diabetes in most DR4 patients.
Owerbach
D
D
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
Gunn
S
S
Gabbay
K H
KH
D000328:Adult; D001483:Base Sequence; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000235:genetics* / Q000276:immunology; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D015804:HLA-DR4 Antigen; D006801:Humans; D015151:Immunoblotting; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes
D006683:HLA-DQ Antigens; C109756:HLA-DQ8 antigen; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; D015345:Oligonucleotide Probes