Comparative evaluation of scavenger properties of exifone, piracetam and vinburnine.
The involvement of radical reactions in the ageing process, physiological as well as pathological, is well demonstrated. It is accepted that alloxan cyto-toxicity is linked to a production of hydroxylated free radicals and that a substance preventing the development of alloxanic diabetes possesses scavenger properties. The objective of this work was to demonstrate, in this model, the anti-radical effect of 3 molecules recommended in the treatment of cerebral insufficiency and a reference substance (+)-catechin. We observed a protective action with catechin (P less than 0.05) at the highest dose (100 mg/kg). PEG alone was moderately active but comparison of PEG-alloxan and PEG-exifone-alloxan showed a highly significant difference (P less than 0.001) at the two highest doses (60 and 120 mg/kg). Piracetam (200 and 400 mg/kg) and vinburnine (7.5 and 15 mg/kg) were inactive. Under these experimental conditions, exifone demonstrated remarkable anti-radical properties.
Bentue-Ferrer
D
D
Laboratory of Clinical and Experimental Pharmacology, Faculté de Médecine, Rennes, France.
Philouze
V
V
Pape
D
D
Reymann
J M
JM
Allain
H
H
Van den Driessche
J
J
D000818:Animals; D001577:Benzophenones / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D002392:Catechin / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology; D005609:Free Radicals; D008297:Male; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014748:Vinca Alkaloids / Q000494:pharmacology*
D001577:Benzophenones; D001786:Blood Glucose; D005609:Free Radicals; D011760:Pyrrolidinones; D014748:Vinca Alkaloids; C052932:exifone; D002392:Catechin; C016422:eburnamonine; D010889:Piracetam