Ketogenic diets in the treatment of epilepsy: short-term clinical effects.
The classical 4:1 ketogenic diet, the medium-chain triglyceride (MCT) diet and a modified MCT diet were used in the treatment of 55 children and four adults with intractable epilepsy. During a three-month treatment period 51 of 63 studies (81 per cent) showed greater than 50 per cent reduction in seizure frequency. This improvement was independent of diet used and type of seizure experienced by patients. The diets were found to be acceptable and of therapeutic benefit to the children, but treatment of the four adult patients with the MCT diet was unsuccessful. There was no correlation between EEG changes and clinical response. The three ketogenic diets were shown to be effective in the short-term management of children whose epilepsy is poorly controlled with anticonvulsant drugs.
Schwartz
R H
RH
University Department of Paediatrics, John Radcliffe Hospital, Oxford.
Eaton
J
J
Bower
B D
BD
Aynsley-Green
A
A
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004041:Dietary Fats / Q000008:administration & dosage* / Q000009:adverse effects; D004569:Electroencephalography; D004827:Epilepsy / Q000097:blood / Q000178:diet therapy*; D005071:Evoked Potentials; D006801:Humans; D007657:Ketone Bodies / Q000097:blood; D008875:Middle Aged; D014280:Triglycerides / Q000008:administration & dosage*
D004041:Dietary Fats; D007657:Ketone Bodies; D014280:Triglycerides