HLA A1, B8, DR3 extended haplotypes in autoimmune chronic hepatitis.
Genetic determinants of the autoimmune type of chronic active hepatitis include the major histocompatibility complex alleles HLA-B8 and HLA-DR3, which are usually present as the haplotype A1, B8, DR3. In certain other autoimmune diseases, an extended haplotype including complement alleles confers a greater relative risk than does B8, DR3. Hence, extended haplotypes were ascertained in autoimmune chronic active hepatitis by typing for HLA, complement alleles C4A, C4B, and Bf, and glyoxalase type 1 or 2. Eight of the 10 B8, DR3 haplotypes were A1, B8, DR3. Of the 8, 7 had the extended haplotype A1, B8, C4AQ0, C4B1, BfS, DR3, but this haplotype occurred in four instances with glyoxalase 2 and in three with glyoxalase 1. Thus, we find that in autoimmune chronic active hepatitis there is a high frequency of null alleles for complement but an extended haplotype does not cause any greater risk for disease than B8, DR3 alone.
Tait
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B
Tissue Typing Laboratory, Royal Melbourne Hospital, Walter and Eliza Hall Institute of Medical Research, Victoria, Australia.
Mackay
I R
IR
Board
P
P
Coggan
M
M
Emery
P
P
Eckardt
G
G
D000483:Alleles; D001327:Autoimmune Diseases / Q000235:genetics*; D003165:Complement System Proteins / Q000235:genetics; D005260:Female; D015234:HLA-A Antigens / Q000235:genetics*; D015788:HLA-A1 Antigen; D015235:HLA-B Antigens / Q000235:genetics*; D015795:HLA-B8 Antigen; D006684:HLA-DR Antigens / Q000235:genetics*; D015803:HLA-DR3 Antigen; D006239:Haplotypes; D006521:Hepatitis, Chronic / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male
D015234:HLA-A Antigens; D015788:HLA-A1 Antigen; D015235:HLA-B Antigens; D015795:HLA-B8 Antigen; D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D003165:Complement System Proteins