Antifungal effects of selenocystine and its derivatives on dermatophytes.
Antifungal effects of DL-selenocystine and its derivatives (DL-selenolanthionine, DL-Se-sulfoselenocysteine) and of sodium selenite were tested in 14 dermatophytes and 7 species of keratinolytic and non-keratinolytic soil fungi. Minimal inhibitory concentrations of the compounds were measured and compared to those of ketoconazole. Organic selenocompounds behaved similarly. They were on average less inhibitory than ketoconazole but, in some cases, MICs were equal or even lower. The effects of selenite were but small. The action of selenocystine and ketoconazole in concentrations up to 50 micrograms/ml was found to be mostly fungistatic. Free L-cystine (100 micrograms/ml) antagonized the antifungal effect of its selenoanalog.
Kunert
J
J
D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D003553:Cystine / Q000494:pharmacology / Q000031:analogs & derivatives; D016566:Organoselenium Compounds; D012643:Selenium / Q000494:pharmacology*; D012988:Soil Microbiology
D000935:Antifungal Agents; D016566:Organoselenium Compounds; C009226:selenocystine; D003553:Cystine; D012643:Selenium