Comparative pharmacokinetics of netobimin and albendazole in the one-humped camel (Camelus dromedarius).
Netobimin and albendazole were administered orally to camels (n = 5 + 5) at molecular equivalent dosages, 15.8 and 10.0 mg/kg body wt, respectively. The plasma profiles of the two main metabolites were investigated for 54 h by high performance liquid chromatography. The metabolism and the disposition of both anthelmintics in camels were similar to sheep rather than to cattle. These results indicate that netobimin and albendazole are likely to be excellent anthelmintics for camels.
Delatour
P
P
Ouhsine
A
A
Benoit
E
E
D015766:Albendazole / Q000493:pharmacokinetics*; D000818:Animals; D000871:Anthelmintics / Q000493:pharmacokinetics*; D001682:Biological Availability; D002162:Camelus / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006146:Guanidines / Q000493:pharmacokinetics*; D012016:Reference Values
D000871:Anthelmintics; D006146:Guanidines; D015766:Albendazole; C049626:netobimin