Effects of 5-hydroxytryptamine on rapidly adapting pulmonary stretch receptor activity in the rabbit.
In anesthetized rabbits, intravenous administration of 5-hydroxytryptamine (5-HT, 10, 20, 40 and 80 micrograms/kg) led to an increase of rapidly adapting pulmonary stretch receptor activity. The magnitude of the increase was dose-dependent. The excitatory responses to any doses of 5-HT were not inhibited by prior treatment with isoprenaline (100-150 micrograms). The results indicate that the stimulation of rapidly adapting pulmonary stretch receptors by 5-HT is not caused by contraction of the airway smooth muscle.
Matsumoto
S
S
First Department of Physiology, Fukushima Medical College, Japan.
Shimizu
T
T
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D007545:Isoproterenol / Q000494:pharmacology; D008168:Lung / Q000294:innervation*; D008465:Mechanoreceptors / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D007545:Isoproterenol