Nuclear medicine studies of aging--VIII. Bone to soft-tissue ratio of 99mTc labeled MDP and HMDP vs age.
An objective approach to determine whether there was an advantage of using 99mTc-MDP or 99mTc-HMDP for bone imaging, particularly in elderly subjects, was evaluated by measuring the bone to soft-tissue ratio in relation to age. This was done by quantifying analog images of the femoral region by using an optical densitometer. A ratio (mean for right and left thighs) was determined for mid-femur to adjacent soft-tissue. These values were analyzed in relation to the age of patients studied with either MDP or HMDP. Little correlation with age was observed. An analysis at 10-year intervals of age indicated a decline in the ratio after 70 years, without any significant difference between MDP and HMDP.
Kassamali
H
H
Department of Nuclear Medicine, University of Connecticut Health Center, Farmington 06032.
Hosain
F
F
Spencer
R P
RP
Layne
W W
WW
Karimeddini
M K
MK
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D006801:Humans; D008875:Middle Aged; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives
C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013669:Technetium Tc 99m Medronate