title: Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans.
abstract: The Caenorhabditis elegans gene unc-22 encodes a very large muscle protein, called twitchin, which consists of a protein kinase domain and several copies of two short motifs. The sequence of twitchin has unexpected similarities to the sequences of proteins of the immunoglobulin superfamily, cell adhesion molecules and vertebrate muscle proteins, including myosin light-chain kinase. These homologies, together with results from earlier genetic and molecular analyses, indicate that twitchin is involved in a novel mechanism of myosin regulation.
authors: Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322.
authors: G M
authors: GM
authors: Benian
authors: J E
authors: JE
authors: Kiff
authors: N
authors: N
authors: Neckelmann
authors: D G
authors: DG
authors: Moerman
authors: R H
authors: RH
authors: Waterston
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002107:Caenorhabditis / Q000235:genetics* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins; D002148:Calmodulin-Binding Proteins; D005796:Genes; D015801:Helminth Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics*; D009219:Myosin-Light-Chain Kinase / Q000235:genetics; D009218:Myosins / Q000378:metabolism*; D011494:Protein Kinases / Q000235:genetics*; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
chemical_list: D029742:Caenorhabditis elegans Proteins; D002148:Calmodulin-Binding Proteins; D015801:Helminth Proteins; D009124:Muscle Proteins; C489233:unc-22 protein, C elegans; D011494:Protein Kinases; D009219:Myosin-Light-Chain Kinase; D009218:Myosins