Antibody production in rats after long-term exposure to formaldehyde.
Sprague-Dawley rats were vaccinated with pneumococcal polysaccharide antigens and tetanus toxoid to evaluate the immunologic effects of long-term formaldehyde exposure. The antibody response to vaccination was measured 3 to 4 weeks later by enzyme-linked immunosorbent assay. An IgG response to pneumococcal polysaccharides and to tetanus toxoid was found in both the formaldehyde-exposed group and a control group of rats not exposed to formaldehyde. The IgM response to tetanus toxoid was significant in both groups but neither group showed a significant IgM response to pneumococcal polysaccharides. There were thus no signs of impaired B-cell function in rats exposed to a high concentration (12.6 ppm) of formaldehyde for nearly 2 years.
Holmström
M
M
Department of Otolaryngology, Huddinge Hospital, Karolinska Institutet, Sweden.
Rynnel-Dagöö
B
B
Wilhelmsson
B
B
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D004781:Environmental Exposure; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005557:Formaldehyde / Q000276:immunology / Q000633:toxicity*; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D013745:Tetanus Toxoid / Q000276:immunology*; D014611:Vaccination
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011135:Polysaccharides, Bacterial; D013745:Tetanus Toxoid; D005557:Formaldehyde