Computation of diagnostic data from coronary sinus pressure: a comparison between two possible models.
We have evaluated two mathematical models to describe the increase in coronary sinus pressure (CSP) following pressure controlled intermittent coronary sinus occlusion (PICSO). The models are evaluated and compared on the basis of human and canine data. Both models were fitted by non-linear least squares algorithms. Next, derived quantities, such as plateau, rise-time and mean integral of the coronary sinus pressure were calculated from the model parameters. Corresponding quantities for the two models were compared with regard to mean values, rate of successful calculation and specific features characterizing the human or canine case. One model was found to be superior for investigational purposes. The other model was found to be more stable in critical situations and is therefore suggested for usage in closed loop regulation of PICSO. Physiologically, the differences in mean values of the derived quantities between the two models were found to be negligible. The formal statistical significance of the differences is but a consequence of the large number of PICSO cycles analysed.
Schreiner
W
W
Second Surgical Department, University of Vienna, Austria.
Neumann
F
F
Schuster
J
J
Froehlich
K C
KC
Sun
Y
Y
Mohl
W
W
D000465:Algorithms; D000818:Animals; D001794:Blood Pressure; D003326:Coronary Circulation; D003971:Diastole; D004285:Dogs; D006801:Humans; D008432:Mathematical Computing; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000601:surgery; D013599:Systole