title: Modulation of collagen synthesis in human glomerular epithelial cells by interleukin 1.
abstract: Human glomerular epithelial cells produce matrix material e.g. collagen type IV. In vitro, the synthesis of collagen can be monitored by the incorporation of 3H-proline, a precursor molecule of the collagens. We report on the enhancement of collagen synthesis by glomerular epithelial cells with highly purified or recombinant I1-1. Since I1-1 is released from monocytes or glomerular mesangial cells by inflammatory mediators, our results point to a participation of I1-1 in the development of sclerosis, which is seen in many forms of chronic inflammatory diseases.
authors: Institut für Immunologie, Universität Heidelberg, FRG.
authors: I
authors: I
authors: Torbohm
authors: B
authors: B
authors: Berger
authors: M
authors: M
authors: Schönermark
authors: J
authors: J
authors: von Kempis
authors: K
authors: K
authors: Rother
authors: G M
authors: GM
authors: Hänsch
mesh_terms: D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D007678:Kidney Glomerulus / Q000187:drug effects / Q000378:metabolism*; D009000:Monocytes / Q000502:physiology
chemical_list: D007375:Interleukin-1; D003094:Collagen