Placental weights of normal and aneuploid early human fetuses.
Placental and body weights were plotted for 252 normal human fetuses less than 600 gm and mean regressions and 95% prediction intervals were calculated. Placentas from 62 aneuploid fetuses were compared to these standards. Placenta to body weight ratios from 34 trisomy-21 fetuses were not reduced but those from 15 trisomy-18 fetuses were generally decreased. One of 5 trisomy-13 ratios was below the prediction interval. Among 7 triploid fetuses the ratios were above the normal interval in 3 and below normal in 4. Three of the triploids that were below were associated with a karyotype of 69,XXX and did not have hydatidiform degeneration. All 4 placentas with hydatidiform changes were abnormally large. All of the 7 triploids had 3-4 syndactyly and 3 had hydrocephalus.
Shepard
T H
TH
Department of Pediatrics, School of Medicine, University of Washington, Seattle 98195.
FitzSimmons
J M
JM
Fantel
A G
AG
Pascoe-Mason
J
J
D000782:Aneuploidy; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005260:Female; D005333:Fetus / Q000166:cytology*; D006801:Humans; D007621:Karyotyping; D008297:Male; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology*; D012729:Sex Chromosome Aberrations; D013223:Statistics as Topic