The effect of ketanserin on serotonin-induced vascular responses in the isolated perfused rat lung.
Based on a vasoconstrictor role for serotonin (5-HT) in various types of cardiopulmonary conditions the effect of the 5-HT2 receptor antagonist, ketanserin, on 5-HT-induced responses in the intact, isolated rat lung was investigated. 5-HT produced biphasic responses consisting of weak vasodilator and predominant, dose-dependent constrictor components. Ketanserin showed no direct vasodilator effects but could completely antagonise the 5-HT-induced vasoconstrictor responses, suggesting that this response was 5-HT2 receptor-mediated.
Le Roux
M G
MG
Department of Pharmacology, School of Pharmacy, University of the Western Cape, Bellville, Cape Province, South Africa.
Syce
J A
JA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007650:Ketanserin / Q000494:pharmacology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011652:Pulmonary Circulation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects
D012701:Serotonin; D007650:Ketanserin