Effects of morphine and pethidine in vitro on longitudinal and circular muscle tension of bovine coronary artery.
The effects of morphine and pethidine on the tension in longitudinal and circular muscle from bovine coronary arteries have been compared. Pethidine caused constriction in circular muscle while morphine caused relaxation. In longitudinal muscle, pethidine caused relaxation while morphine had no effect. Like morphine, noradrenaline in comparable doses relaxed circular muscle and had minimal effects on longitudinal muscle. If the difference in the response to morphine and pethidine demonstrated here also applies to human coronary arteries, the clinical implications are potentially important.
Helgesen
K G
KG
Institute of Medical Biology, University of Tromsø, Ullevaal hospital, Norway.
Tindall
A
A
D000818:Animals; D002417:Cattle; D003331:Coronary Vessels; D066298:In Vitro Techniques; D008614:Meperidine / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*
D009020:Morphine; D008614:Meperidine