title: Human alpha-L-fucosidase: complete coding sequence from cDNA clones.
abstract: The human lysosomal storage disorder fucosidosis results from the deficiency of alpha-L-fucosidase, a lysosomal enzyme essential for the catabolism of oligosaccharides containing alpha-L-fucosides. cDNA clones coding for human alpha-L-fucosidase have been isolated from lambda gt10 and lambda gt11 cDNA libraries derived from human liver, placenta and colon. Compilation of cDNA sequences results in a nucleotide sequence of 2053 base pairs encoding alpha-L-fucosidase. The sequence contains an open reading frame of 461 amino acids beginning with the first in-frame methionine and includes 439 amino acids which comprise the mature protein in addition to a hydrophobic signal peptide sequence of 22 amino acids.
authors: Department of Chemical Pathology, Adelaide Medical Centre for Women and Children, South Australia.
authors: T
authors: T
authors: Occhiodoro
authors: K R
authors: KR
authors: Beckmann
authors: C P
authors: CP
authors: Morris
authors: J J
authors: JJ
authors: Hopwood
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000235:genetics*; D015342:DNA Probes; D015698:Genomic Library; D006801:Humans; D008969:Molecular Sequence Data; D015183:Restriction Mapping; D005644:alpha-L-Fucosidase / Q000235:genetics*
chemical_list: D015342:DNA Probes; D004247:DNA; D005644:alpha-L-Fucosidase