title: Polymers of random short oligonucleotides detect polymorphic loci in the human genome.
abstract: Polymers of random 14 mer oligonucleotides are shown to detect discrete loci in the human genome. Eighteen different synthetic tandem repeats of random 14 base-pair units (STRs) have been generated and all of them turn out to detect polymorphic loci on southern blots of human DNA samples, presumably corresponding to a variable number of tandem repeats (VNTR). This finding suggests that minisatellites are a major component of the human genome and are strongly associated with the generation of genetic variability. In addition, it should open new strategies to make new polymorphic probes available.
authors: Laboratoire de Génétique Moléculaire, Centre d'Etudes du Bouchet, Vert-le-Petit, France.
authors: G
authors: G
authors: Vergnaud
mesh_terms: D001482:Base Composition; D001483:Base Sequence; D003001:Cloning, Molecular; D005260:Female; D015894:Genome, Human; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D009838:Oligodeoxyribonucleotides; D010375:Pedigree; D011110:Polymorphism, Genetic
chemical_list: D009838:Oligodeoxyribonucleotides