Pharmacokinetics of amikacin in hematologic malignancies.
The pharmacokinetics of amikacin in 10 patients with hematologic malignancies and 1 patient with aplastic anemia were investigated. At an administered dose of 7 mg/kg of body weight, a volume of distribution of 0.4 liters/kg, an elimination half-life of 3.0 h, and a total body clearance of 2.1 ml/min per kg, amikacin achieved a peak level in blood of 21 micrograms/ml. Results of the study revealed that there was a marked increase in volume of distribution of amikacin in these patients compared with normal.
Kaojarern
S
S
Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand.
Maoleekoonpairoj
S
S
Atichartakarn
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V
D000328:Adult; D000583:Amikacin / Q000493:pharmacokinetics*; D000741:Anemia, Aplastic / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007938:Leukemia / Q000378:metabolism*; D008223:Lymphoma / Q000378:metabolism*; D008875:Middle Aged; D013997:Time Factors
D000583:Amikacin