Mutant frequency of radiotherapy technicians appears to be associated with recent dose of ionizing radiation.
The frequency of hypoxanthine phosphoribosyl transferase (HPRT) mutants among peripheral T-lymphocytes of radiotherapy technicians primarily exposed to 60Co was measured by the T-cell cloning method. Mutant frequencies of these technicians in 1984 and 1986 were significantly higher than those of physiotherapy technicians who worked in a neighboring service, and correlated significantly with thermoluminescence dosimeter readings recorded during the 6 mo preceding mutant frequency determination. Correlations decreased when related to dose recorded over longer time intervals. HPRT mutant frequency determination in peripheral lymphocytes is a good measure of recently received biologically effective radiation dose in an occupationally exposed population.
Messing
K
K
Département des Sciences biologiques, Université du Québec à Montréal, Canada.
Ferraris
J
J
Bradley
W E
WE
Swartz
J
J
Seifert
A M
AM
D000328:Adult; D000488:Allied Health Personnel; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics* / Q000528:radiation effects; D009154:Mutation; D026741:Physical Therapy Modalities; D011829:Radiation Dosage; D011878:Radiotherapy; D013679:Technology, Radiologic
D007041:Hypoxanthine Phosphoribosyltransferase