[Inactivation of cytochrome P-450 by hydrogen peroxide formed in the catalytic cycle during peroxy-complex degradation].
It was shown that the crucial role in the inactivation of microsomal cytochrome P-450 in reactions of hydroxylation of type I (DMA, AP, BPh, p-NA) and type II (AN) substrates belongs to H2O2 directly formed in the enzyme active center during the decomposition of the peroxy complex. Hydrogen peroxide formed via an indirect pathway during the dismutation of superoxide radicals does not play a role in the hemoprotein inactivation.
Mengazetdinov
D E
DE
Karuzina
I I
II
Archakov
A I
AI
D000818:Animals; D001386:Azides / Q000494:pharmacology; D001665:Binding Sites; D002384:Catalysis; D065607:Cytochrome P-450 Enzyme Inhibitors; D006420:Hemeproteins / Q000037:antagonists & inhibitors; D006861:Hydrogen Peroxide / Q000378:metabolism*; D019811:Hydroxylamine; D006898:Hydroxylamines / Q000494:pharmacology; D008297:Male; D008861:Microsomes / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D011817:Rabbits; D019810:Sodium Azide; D013379:Substrate Specificity
D001386:Azides; D065607:Cytochrome P-450 Enzyme Inhibitors; D006420:Hemeproteins; D006898:Hydroxylamines; D019811:Hydroxylamine; D019810:Sodium Azide; D006861:Hydrogen Peroxide; D006899:Mixed Function Oxygenases
Inaktivatsiia tsitokhroma P-450 perekis'iu vodoroda, obrazuiushcheĭsia v kataliticheskom tsikle pri raspade peroksikompleksa.