Pharmacokinetics and tissue distribution of parenterally administered human alpha-lymphotoxin in normal and meth-A tumor-bearing BALB/c mice.
These in vivo studies examine the pharmacokinetics of parenterally administered purified, native human alpha-lymphotoxin (LT) in normal and Meth-A bearing BALB/c mice. We found that the lytic activity of alpha-LT was inactivated within 5 h in the blood of both normal and tumor-bearing mice in vivo. However, LT bioactivity in vitro was not affected by incubation with fresh serum. Radioiodinated LT was rapidly sequestered in the kidneys of both normal and tumor-bearing animals. Systemically administered, radioiodinated LT did not selectively localize in tumor tissues.
Averbook
B J
BJ
Department of Surgery, University of California, Irvine.
Jeffes
E B
EB
Yamamoto
R S
RS
Masunaka
I
I
Kobayashi
M
M
Granger
G A
GA
D000818:Animals; D006801:Humans; D007263:Infusions, Parenteral; D007457:Iodine Radioisotopes; D008233:Lymphotoxin-alpha / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008748:Methylcholanthrene; D051379:Mice; D008807:Mice, Inbred BALB C; D012513:Sarcoma, Experimental / Q000139:chemically induced; D012710:Serum Albumin, Bovine / Q000493:pharmacokinetics; D012711:Serum Albumin, Radio-Iodinated / Q000493:pharmacokinetics; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D008233:Lymphotoxin-alpha; D012711:Serum Albumin, Radio-Iodinated; D012710:Serum Albumin, Bovine; D008748:Methylcholanthrene