Studies on the suppression of HL-60 cell growth in vitro by low molecular weight suppressor of human fetal liver origin.
In human fetal liver there are at least two kinds of cell growth suppressor, arginase and a low molecular weight suppressor, both are cytotoxic towards HL-60 cells under the condition of in vitro culture, and mainly present in the supernatant of fetal liver cell suspension. As compared with arginase, the low molecular weight suppressor shows a preferential suppression on HL-60 cell growth rather than that of granuloid-macrophage progenitors of normal human bone marrow.
Wu
C T
CT
Department of Experimental Hematology, Beijing Institute of Radiation Medicine, People's Republic of China.
Wang
Y Z
YZ
Pei
X T
XT
D001119:Arginase / Q000378:metabolism; D006131:Growth Inhibitors; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology*; D008099:Liver / Q000196:embryology*; D008854:Microscopy, Electron; D008970:Molecular Weight; D014357:Trypsin / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D006131:Growth Inhibitors; D014357:Trypsin; D001119:Arginase