High frequency of coeliac disease in adult patients with type-I diabetes.
Anti-reticulin antibodies were measured by an indirect immunofluorescence method in 195 consecutive patients with insulin-dependent diabetes mellitus, and positive titres were found in 8 patients. A jejunal biopsy was performed in these patients, all of whom had small-intestinal atrophy. Thus the frequency of coeliac disease in adult diabetes patients was 4.1%. The patients had no signs of malabsorption or of significant abdominal complaints. We conclude that coeliac disease is commoner in type-I diabetes than in the normal population, and measurement of anti-reticulin antibodies seems to be a suitable screening method.
Collin
P
P
Dept. of Internal Medicine, Tampere University, Central Hospital, Finland.
Salmi
J
J
Hällström
O
O
Oksa
H
H
Oksala
H
H
Mäki
M
M
Reunala
T
T
D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D002446:Celiac Disease / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D005387:Finland; D006801:Humans; D007421:Intestine, Small / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012155:Reticulin / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D012155:Reticulin