title: Antibodies to nuclear lamin proteins in liver disease.
abstract: Sera of patients with autoimmune liver disease contained antibodies reactive with nuclear lamins. These antigens were identified in immunoblotting experiments, using isolated nuclei, nuclear matrices, nuclear lamina-pore complexes and purified lamins as antigen source. The lamins were, furthermore, characterized by 2-dimensional gel electrophoresis. Antibodies to nuclear lamins were found in 75 per cent of the active lupoid hepatitis cases, but not in patients with inactive disease. Anti-lamin antibodies were detected in 8 per cent of primary biliary cirrhosis sera. The autoimmune liver disease sera recognized predominantly the nuclear lamins A/C, and less frequently the lamins A/B/C or lamin B.
authors: Institute of Tumorbiology-Cancer Research, University of Vienna, Austria.
authors: J
authors: J
authors: Wesierska-Gadek
authors: E
authors: E
authors: Penner
authors: E
authors: E
authors: Hitchman
authors: G
authors: G
authors: Sauermann
mesh_terms: D000974:Antibodies, Antinuclear / Q000302:isolation & purification*; D001327:Autoimmune Diseases / Q000276:immunology; D006505:Hepatitis / Q000276:immunology; D006801:Humans; D007797:Laminin / Q000276:immunology*; D008105:Liver Cirrhosis, Biliary / Q000276:immunology; D008107:Liver Diseases / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D007797:Laminin