Antibacterial activity of the dialysates and sera during treatment with chemotherapeutic combinations in continuous ambulatory peritoneal dialysis (CAPD).
In everyday clinical practice, different chemotherapeutics are mostly applied intraperitoneally in treating continuous ambulatory peritoneal dialysis (CAPD) peritonitis. Antibacterial activity of the dialysates and sera were studied, according to their bacteriostatic effect after the intraperitoneal and/or peroral administration of chemotherapy. All samples were tested by the two-fold dilution method. We found that the best therapeutical effect is obtained by applying the combination of two compatible chemotherapeutics, in which the first acts in the peritoneal cavity, and the other represents the "pool" of chemotherapeutics forming a barrier to the spreading of bacteria into other distant parts of the body.
Beader
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Institute of Microbiology, Public Health School Andrija Stampar, Medical Faculty, University of Zagreb, Yugoslavia.
Zagar
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D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000378:metabolism; D001202:Ascitic Fluid / Q000378:metabolism*; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D006801:Humans; D007274:Injections, Intraperitoneal; D010531:Peritoneal Dialysis, Continuous Ambulatory; D015610:Serum Bactericidal Test
D000900:Anti-Bacterial Agents