Lymphocyte subsets in kala-azar.
We examined lymphocyte subsets in peripheral blood from children with visceral leishmaniasis both in the active stage of the disease and after recovery. At diagnosis, CD2+ and CD4+ cells showed a significant decrease while CD8+ cells were significantly increased when compared with controls; CD4/CD8 ratio was inverted. All of these alterations returned to normal values 3 months after recovery.
Sciotto
A
A
Department of Pediatrics, University of Catania, Italy.
Russo-Mancuso
G
G
Zinna
C M
CM
Comisi
F F
FF
Sciannaca
R M
RM
Schiliro
G
G
D000740:Anemia / Q000209:etiology; D000913:Antibodies, Protozoan / Q000032:analysis; D015703:Antigens, CD / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D002675:Child, Preschool; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000150:complications / Q000276:immunology*; D007970:Leukopenia / Q000209:etiology; D008214:Lymphocytes / Q000276:immunology*; D013997:Time Factors
D000913:Antibodies, Protozoan; D015703:Antigens, CD; D015704:CD4 Antigens; D007136:Immunoglobulins