Immunization of cattle with the MSP-1 surface protein complex induces protection against a structurally variant Anaplasma marginale isolate.
The Anaplasma marginale surface protein complex MSP-1 of the Florida isolate is composed of a 105-kilodalton (kDa) polypeptide, which bears a neutralization-sensitive epitope, and a 100-kDa polypeptide. Antigenically similar polypeptides in the Okanogan, Wash. (Washington-O), isolate MSP-1 are 86 and 100 kDa, respectively. Immunization of cattle with Florida isolate MSP-1 induced antibody titers to both MSP-1 polypeptides and protected cattle against homologous and heterologous challenge.
Palmer
G H
GH
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.
Barbet
A F
AF
Cantor
G H
GH
McGuire
T C
TC
D000709:Anaplasma / Q000276:immunology*; D000712:Anaplasmosis / Q000517:prevention & control*; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D000954:Antigens, Surface / Q000008:administration & dosage; D001426:Bacterial Proteins / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D008970:Molecular Weight; D013045:Species Specificity
D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001426:Bacterial Proteins