Myopathic form of arthrogryposis and microcirculation lesion.
A microvascular lesion characterized by extensive platelet aggregation, thrombosis, vascular damage with hemorrhages was found in the muscle of a 2-month-old boy with a myopathic form of the arthrogryposis syndrome. The lesion morphologically resembled the vascular leakage seen in immunologically mediated tissue injury. A degradative effect of proteases released during platelet and neutrophil aggregation on the muscle and joints is suggested.
Fidziańska
A
A
Department of Neurology, Medical Academy, Warsaw, Poland.
Goebel
H H
HH
Burck-Lehmann
U
U
D001176:Arthrogryposis / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008297:Male; D009132:Muscles / Q000098:blood supply / Q000473:pathology*; D009135:Muscular Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*