title: The effect of a cystamine derivative, bis[2-(E-2-hexenoylamino)ethyl] disulfide, on rat platelet aggregation.
abstract: Bis[2-(E-2-alkenoylamino)ethyl] disulfides (compds. I), synthesized from cystamine and 2-trans fatty acids, inhibited collagen-induced rat and rabbit platelet aggregation. The most potent compound was bis[2-(E-2-hexenoylamino)ethyl] disulfide (compd. I-1), and this compound suppressed thromboxane B2 formation from arachidonic acid in rat platelets. The results suggested that compd. I-1 has an inhibitory effect on cyclooxygenase.
authors: T
authors: T
authors: Mimura
authors: H
authors: H
authors: Nakajima
authors: K
authors: K
authors: Tsujikawa
authors: M
authors: M
authors: Haruyama
authors: B G
authors: BG
authors: Lee
authors: Y
authors: Y
authors: Kohama
authors: I
authors: I
authors: Kohda
authors: M
authors: M
authors: Iwai
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis*; D000818:Animals; D003538:Cystamine / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000031:analogs & derivatives; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep
chemical_list: D000475:Alkenes; D010975:Platelet Aggregation Inhibitors; C061601:bis(2-(2-hexenoylamino)ethyl) disulfide; D003538:Cystamine