[Hidden IgM rheumatoid factor in chronic juvenile arthritis. An open multicenter diagnostic study].
244 patients with a provisional diagnosis of juvenile chronic arthritis were investigated for serological presence of "hidden" IgM-rheumatoid-factor with a newly developed ELISA-technique. By clinical and laboratory criteria 130 patients were left with proven JCA. In active polyarticular disease "hidden" IgM-RF was found in 65%, whereas in pauciarticular disease (type I, II) a positive "hidden" IgM-RF rather excludes a patient from these two groups. A positive "hidden" IgM-RF with pauciarticular onset was seen in older girls (greater than 10 years) even in an inactive state and in younger patients with a changing clinical pattern to polyarticular disease.
Dippell
J
J
Clementine-Kinderhospital, Frankfurt/Main.
D000293:Adolescent; D000974:Antibodies, Antinuclear / Q000032:analysis; D001171:Arthritis, Juvenile / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D015796:HLA-B27 Antigen / Q000032:analysis; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D012217:Rheumatoid Factor / Q000032:analysis*
D000974:Antibodies, Antinuclear; D015796:HLA-B27 Antigen; D007075:Immunoglobulin M; D012217:Rheumatoid Factor
"Hidden"-IgM-Rheumafaktor bei juveniler chronischer Arthritis. Eine offene Multicenter-Diagnostikstudie.