B cell dependent T cell function blocked by perinatal exposure of mice to anti-IgM antibodies.
Mice born to mothers deprived of B lymphocytes by their chronic treatment with anti-IgM antibodies (Su/N) do not possess naturally occurring anti-ids (present in sera of normal mice at 2 weeks of age) up to 10 weeks, despite the presence of normal levels of B cells and serum Ig (in these animals). Su/N mice of the same age also lack a T cell subset which together with anti-ids are thought to participate in an antisuppressor regulatory pathway. It is suggested that early development of these T cells may be linked and be dependent on the presence of these anti-ids synthesized early in ontogeny, providing one explanation for a selective T cell deficiency of B cell-deprived mice.
Gordon
J
J
Department of Surgery, McGill University, Montreal, Quebec, Canada.
Mitrovski
B
B
Abikar
K
K
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D001402:B-Lymphocytes / Q000502:physiology*; D007112:Immunity, Maternally-Acquired; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D007136:Immunoglobulins / Q000032:analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000502:physiology*
D000888:Antibodies, Anti-Idiotypic; D007130:Immunoglobulin Idiotypes; D007075:Immunoglobulin M; D007136:Immunoglobulins