title: Apparent coagulopathy caused by infusion of shed mediastinal blood and its prevention by washing of the infusate.
abstract: We found that reinfusion of shed mediastinal blood (SMB) after a cardiac operation was associated with laboratory evidence of disseminated intravascular coagulation. In view of this, we compared the effect of infusing washed or unwashed SMB on the coagulation profiles and blood use of two serial groups of patients undergoing cardiopulmonary bypass. We found that the results of testing for fibrin degradation products converted from negative to positive in 17 of 20 patients who received unwashed SMB versus 1 of 14 patients who received washed SMB (p less than 0.0001). Other coagulation studies did not reveal disseminated intravascular coagulation in either group, nor were there differences in blood use between the two groups. The unwashed SMB contained high titers of fibrin degradation products (mean reciprocal titer = 354 +/- 161) compared with washed SMB (mean reciprocal titer = 34 +/- 18) (p less than 0.01). Based on the volume of SMB infused, the amount of fibrin degradation products in unwashed SMB was sufficient to account for the positive fibrin degradation product assays after infusion in this group. We conclude that infusion of unwashed SMB may confuse the interpretation of tests for disseminated intravascular coagulation or fibrinolysis. As this could lead to unnecessary blood component use and is preventable by washing before infusion, we recommend that the routine infusion of unwashed SMB no longer be employed.
authors: Department of Cardiothoracic Surgery, University of California, San Diego.
authors: L D
authors: LD
authors: Griffith
authors: G F
authors: GF
authors: Billman
authors: P O
authors: PO
authors: Daily
authors: T A
authors: TA
authors: Lane
mesh_terms: D001780:Blood Coagulation Tests; D001804:Blood Transfusion, Autologous / Q000009:adverse effects* / Q000379:methods; D001026:Coronary Artery Bypass; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology* / Q000517:prevention & control; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D008482:Mediastinum; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology* / Q000517:prevention & control; D013997:Time Factors
chemical_list: D005338:Fibrin Fibrinogen Degradation Products