Elevated serum levels of soluble interleukin-2 receptors in HTLV-I--associated myelopathy.
Using an enzyme-linked immunosorbent assay, we measured the level of soluble interleukin-2 receptors (sIL-2Rs) in the serum of 50 normal controls, 48 human carriers of T cell leukemia virus type I (HTLV-I) antibody who had no symptoms, 11 patients with HTLV-I-associated myelopathy (HAM), and 39 patients with adult T cell leukemia (ATL) (four smoldering, 10 chronic, nine lymphoma, and 16 acute type). The highest levels of sIL-2R were observed in patients with acute and lymphoma-type ATL, as opposed to those with chronic and smoldering-type ATL. The levels of sIL-2R in patients with HAM were roughly between those of smoldering ATL and healthy HTLV-I carriers. Serum sIL-2R levels in healthy carriers were also elevated compared with those in normal controls. These observations suggest that the measurement of sIL-2R levels in patients with ATL can be useful as a noninvasive measure of tumor burden and should aid in the understanding of the natural history of HTLV-I infection leading to the development of ATL.
Yamaguchi
K
K
Blood Transfusion Service, Kumamoto University Medical School, Japan.
Nishimura
Y
Y
Kiyokawa
T
T
Takatsuki
K
K
D000328:Adult; D000368:Aged; D002353:Carrier State; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015490:HTLV-I Infections / Q000150:complications*; D006801:Humans; D015461:Leukemia, Prolymphocytic, T-Cell / Q000097:blood; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000097:blood; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000097:blood; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D013118:Spinal Cord Diseases / Q000097:blood / Q000209:etiology*
D015375:Receptors, Interleukin-2