The effects of cadmium, mercury and lead in vitro on hepatic microsomal mixed function oxidase and lipid peroxidation.
In this study, the authors investigated the effect of cadmium, mercury and lead in vitro on hepatic microsomal mixed function oxidase and lipid peroxidation. The results showed that these metals could inhibit the activity of hepatic microsomal aniline hydroxylase, decrease the concentration of hepatic microsomal cytochrome P-450 and increase the concentration of the inactive form of hemoprotein, P-420. Besides, they could enhance hepatic microsomal lipid peroxidation. There were marked concentration-dependent responses in these microsomal reactions. Thus, it may be suggested that cadmium, mercury and lead are capable of impairing hepatic microsomal mixed function oxidase in vitro by stimulating membrane lipid peroxidation.
Xiao
G H
GH
Wu
J L
JL
Liu
Y G
YG
D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D007854:Lead / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008628:Mercury / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D002104:Cadmium; D007854:Lead; D003577:Cytochrome P-450 Enzyme System; D000815:Aniline Hydroxylase; D008628:Mercury