Results of radiotherapy of cervix cancer stage IB depending on the techniques of intracavitary gamma-therapy.
The results of radiotherapy in 219 patients with cervix cancer stage IB have been presented. Among them, 38 patients were treated by traditional intracavitary gamma-therapy, 47 patients by intracavitary irradiation on the principle of simple afterloading, and 134 by remote afterloading. External irradiation on gammatrons was of the same type. The data obtained have shown that the 5-year survival rate of patients treated by a radiation method including gamma therapy on the principle of simple or remote afterloading does not differ essentially (95.7 +/- 3.0 and 95.2 +/- 1.5% respectively). The given value 73.6 +/- 7.6 was well above, in comparison with that in patients irradiated by traditional intracavitary method. The frequency of radiation damage was found by investigation to depend on the variant of gamma-therapy used. Radiation reactions in the course of treatment and after its completion were most frequent in patients irradiated by traditional intracavitary technique. The incidence of vesical, rectal, vaginal radiation damage proved to be significant with intracavitary gamma-therapy used on the principle of remote afterloading. Therefore, taking into account the number of positive points of irradiation on AGAT-B apparatus, scientific investigations must be intensified to choose more optimum regimens of dose fractionation and rhythms of radiation that can ensure the proper clinical result.
Vishnevskaya
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EE
Scientific Research Inst. of Oncology and Medical Radiology of the BSSR Health Ministry, USSR.
D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000379:methods; D005260:Female; D005720:Gamma Rays; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*