Penetration of clindamycin and metronidazole into the appendix and peritoneal fluid in children.
Thirty-one children underwent appendectomy following administration of a single i.v. dose of clindamycin 10 mg/kg or metronidazole 7.5 mg/kg. The serum levels of the antibiotics at that time were comparable, but the tissue concentration of clindamycin in the appendix (mean 7.23 micrograms/g) exceeded that of metronidazole (mean 2.27 micrograms/g). The concurrent mean concentration of metronidazole in peritoneal fluid (14.26 micrograms/ml) was higher than that of clindamycin (7.72 micrograms/ml).
Nagar
H
H
Department of Pediatric Surgery, Tel-Aviv Medical Center, Israel.
Berger
S A
SA
Hammar
B
B
Gorea
A
A
D001065:Appendix / Q000378:metabolism*; D001202:Ascitic Fluid / Q000378:metabolism; D002648:Child; D002981:Clindamycin / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000493:pharmacokinetics*; D010529:Peritoneal Cavity
D008795:Metronidazole; D002981:Clindamycin