[Comparative influence of nootropic preparations on the emetic effect of morphine].
The effect of electroshock (ECS) and piracetam, oxiracetam or N-acetylglycinamide on the passive avoidance conditioned response in rats was studied. The antiemetic effect of the compounds was examined in cats as well. The results obtained allowed us to distinct the nootropic and antiemetic action of the drugs. The substances possessed a similar ability to prevent ECS-induced amnesia. On the contrary, oxiracetam completely prevented the emetic response to morphine at doses 100 times lower and piracetam at doses 10 times higher then those of the opioid. N-Acetylglycinamide had no antiemetic activity. The results obtained show that oxiracetam is 100 times more active in antiemetic test than piracetam. These data comprise the novel properties of nootropic drugs.
Naumova
V I
VI
Krylova
I N
IN
Drozd
Iu V
IuV
Polev
P V
PV
Bashnin
Iu I
IuI
D000648:Amnesia, Retrograde / Q000188:drug therapy / Q000209:etiology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002415:Cats; D003214:Conditioning, Classical / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D005260:Female; D005998:Glycine / Q000494:pharmacology / Q000627:therapeutic use / Q000031:analogs & derivatives; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D010889:Piracetam / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000627:therapeutic use; D011759:Pyrrolidines / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D014839:Vomiting / Q000139:chemically induced*
D011619:Psychotropic Drugs; D011759:Pyrrolidines; C061328:N-acetylglycinamide; D009020:Morphine; C040619:oxiracetam; D005998:Glycine; D010889:Piracetam
Sravnitel'noe vliianie nootropnykh preparatov na émeticheskiĭ éffekt morfina.