Trisomic 22 placenta in a case of severe intrauterine growth retardation.
We describe a case in which a trisomic 22 placenta could be the cause of severe growth retardation in a chromosomally normal female fetus. At amniocentesis a mosaic 46,XX/47,XX, +22 was observed in amniotic fluid specimens sampled on two different occasions, while fetal blood from a diagnostic cordocentesis revealed a normal chromosome constitution. Postnatal studies showed the consistent presence of trisomic 22 cells in the placenta, while only normal metaphases were found in amnion, blood, and fibroblast cultures.
Stioui
S
S
Laboratorio di Citogenetica, Instituti Clinici di Perfezionamento, Milano, Italy.
de Silvestris
M
M
Molinari
A
A
Stripparo
L
L
Ghisoni
L
L
Simoni
G
G
D002824:Chorionic Villi / Q000648:ultrastructure; D002892:Chromosomes, Human, Pair 22; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009030:Mosaicism; D010922:Placenta Diseases / Q000150:complications* / Q000235:genetics; D011247:Pregnancy; D014314:Trisomy