Lack of correlation between HLA types and anti-idiotypic production in family members of a lupus patient.
Correlations of anti-single-stranded (ss) DNA, anti-F(ab')2, and anti-idiotypes to HLA types of 16 healthy family members of a lupus patient were studied. High levels of anti-ss DNA (63%) and anti-F(ab')2 (69%) were detected. Of the 12 family members who expressed HLA-DR2 antigen, 8 had anti-ss DNA and anti-F(ab')2 antibodies. One out of 3 family members who shared the same HLA phenotypes, A1B8DR2, of the proband had high levels of anti-idiotype directed against the proband's F(ab')2 anti-DNA. Though a high prevalence of A1B8DR2, of anti-ss DNA, and of anti-F(ab')2 in healthy family members of a lupus patient was found, anti-idiotypes against anti-DNA were not dependent on HLA-A, B, Dr.
Suenaga
R
R
Department of Medicine, University of Kansas School of Medicine, Kansas City 66103.
Hatfield
M
M
Jones
E
E
Jones
J V
JV
Abdou
N I
NI
D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis*; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001323:Autoantibodies / Q000096:biosynthesis*; D005260:Female; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000235:genetics / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D008297:Male; D010641:Phenotype
D000888:Antibodies, Anti-Idiotypic; D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006680:HLA Antigens; D007130:Immunoglobulin Idiotypes