Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice.
When rodents are infected with the nematode Nippostrongylus brasiliensis, large numbers of eosinophils appear in their blood and lungs and their serum immunoglobulin E (IgE) is increased. Injection of a monoclonal antibody to interleukin-5 completely suppressed the blood eosinophilia and the infiltration of eosinophils in the lungs of parasitized mice but had no effect on serum IgE. In contrast, an antibody to interleukin-4 inhibited parasite-induced IgE but not the eosinophilia. These results show that interleukin-5 is important in eosinophil production in vivo and that IgE and eosinophil production are regulated by different cytokines produced by the TH2 subset of CD4-expressing T cells.
Coffman
R L
RL
DNAX Research Institute, Palo Alto, CA 94304.
Seymour
B W
BW
Hudak
S
S
Jackson
J
J
Rennick
D
D
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D004802:Eosinophilia / Q000209:etiology / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D015847:Interleukin-4; D015848:Interleukin-5; D007378:Interleukins / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009349:Nematode Infections / Q000150:complications* / Q000276:immunology; D009559:Nippostrongylus
D000911:Antibodies, Monoclonal; D015848:Interleukin-5; D007378:Interleukins; D015847:Interleukin-4; D007073:Immunoglobulin E