[Pharmacodynamics of erythromycin lactobionate during tonsillectomy in children].
In 22 children serum levels and concentration of erythromycin in the tonsil tissue after intravenous injection were measured. The concentration of erythromycin in the tonsils one hour after injection was four times the serum level. Two hours after injection the ratio was reduced significantly to 1.2. From the results it is concluded that perioperative antibiotic therapy with erythromycin has pharmacodynamic advantages.
Leuthardt
R
R
Ostschweizerisches Kinderspital, Klinik für Kinderchirurgie, St. Gallen.
Trümpi
B
B
Morger
R
R
D002648:Child; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D011897:Random Allocation; D014068:Tonsillectomy
C010948:erythromycin lactobionate; D004917:Erythromycin
Pharmakodynamik von Erythromycin-Laktobionat während der Tonsillektomie bei Kindern.