[The effect of HLA-DRB4 on the clinical picture of chronic polyarthritis].
61 patients suffering from classic erosive rheumatoid arthritis (RA) with a condition persisting for more than 5 years, were examined together with 69 healthy control subjects with regard to associations to "supertypic" HLA-D specificities. We found a significant increase of HLA-DRw53 in patients with seropositive RA (SPRA) (31/42 patients = 73.8%, Chi 2 = 18.4, p less than 0.01, RR = 7.3). Our results confirm the hypothesis, that the HLA-DRB4 gene is closer related to the disease susceptibility genes of SPRA than of DR4 (DRB1).
Haberhauer
G
G
2. Medizinische Abteilung mit Rheumatologie und Osteologie im Kaiser-Franz-Josef-Spital der Stadt Wien, Osterreich.
Peichl
P
P
D000328:Adult; D000368:Aged; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D005787:Gene Frequency; D005819:Genetic Markers; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics*; D015804:HLA-DR4 Antigen; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
D005819:Genetic Markers; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen
Der Einfluss von HLA-DRB4 auf das klinische Bild der chronischen Polyarthritis.