[Changes in anterior pituitary function during ACTH therapy of patients with infantile spasms].
Serum cortisol, prolactin (PRL), TSH, GH, LH and FSH levels were measured before and immediately after daily ACTH-Z therapy (0.01 mg/kg/day, 1-2 weeks) for 5 patients with infantile spasms and one patient with myoclonus epilepsy. Total number of ACTH-Z therapy were 8 times, and all patients became seizure free after ACTH-Z therapy. In 6 occasions, TRH, LH-RH and insulin tolerance tests were performed before and after daily ACTH-Z therapy. Serum cortisol levels were significantly increased after daily ACTH-Z therapy but all other hormone levels were significantly decreased. In TRH and LH-RH tolerance tests, peak levels and increments of PRL, LH and FSH were significantly decreased after daily ACTH-Z therapy and those of TSH were mildly decreased. In one case insulin tolerance test revealed an adequate decrease of blood glucose before and after ACTH-Z therapy, and there was a poor GH response after ACTH-Z therapy. Daily ACTH-Z therapy was thought to suppress secretion of anterior pituitary hormones.
Shimizu
A
A
Seki
T
T
Ohyama
K
K
Takahashi
T
T
Takuma
Y
Y
Hirai
K
K
Aihara
M
M
Hatakeyama
K
K
D002675:Child, Preschool; D003366:Cosyntropin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010903:Pituitary Gland, Anterior / Q000503:physiopathology*; D013036:Spasms, Infantile / Q000188:drug therapy* / Q000503:physiopathology
D003366:Cosyntropin; C006418:adrenocorticotropin zinc