Functional affinity of antibody to the Haemophilus influenzae type b polysaccharide.
The functional affinity, or avidity, of antibody to the capsular polysaccharide of Haemophilus influenzae (Hib-PS) was measured in serum samples from 12 adult male subjects before and after immunization with Hib-PS vaccine. Mean avidity increased from 0.74 nM-1 to 1.5 nM-1 after immunization (P less than .05, paired Student's t test). The Bureau of Biologics reference antiserum had an avidity constant of 12 nM-1, which was the highest of all 25 serum samples studied.
Griswold
W R
WR
University of California Medical Center, San Diego 92103-9981.
Lucas
A H
AH
Bastian
J F
JF
Garcia
G
G
D000907:Antibodies, Bacterial / Q000032:analysis / Q000276:immunology*; D016667:Bacterial Capsules; D001428:Bacterial Vaccines / Q000276:immunology*; D018073:Haemophilus Vaccines; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007114:Immunization; D008297:Male; D011135:Polysaccharides, Bacterial / Q000276:immunology*
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D011135:Polysaccharides, Bacterial