Evidence for an osteoblast-activating factor in a patient with peripheral T-cell lymphoma and osteosclerosis.
A patient with peripheral T-cell Lymphoma and acquired, systemic osteosclerosis is described. Bone histology showed a spectacular activation of osteoblasts accompanyed by massive new bone formation. Alkaline phosphatase in serum was elevated and increased to greater than 2000 U/l when the lymphoma became refractory to chemotherapy. In the patient's serum an osteoblast-activating factor could be demonstrated using a rat osteogenic osteosarcoma cell line (ROS 17/2.8). The factor was absent during remission of the tumor. We conclude that osteosclerosis was a paraneoplastic syndrome in this patient due to the secretion of an osteoblast-stimulating factor by the T-cell lymphoma. This situation is similar to the secretion of osteoclast-activating factors described in B-cell lymphomas, particularly multiple myeloma. The characterization of such a factor could be of therapeutic relevance.
Hüfner
M
M
Medizinische Klinik und Poliklinik V (Haematologie/Onkologie/Rheumatologie), Universität Heidelberg.
Döhner
H
H
Schmidt
J
J
Möller
P
P
Ho
A D
AD
Hunstein
W
W
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D002460:Cell Line; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008222:Lymphokines / Q000097:blood*; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology* / Q000473:pathology; D008297:Male; D012516:Osteosarcoma / Q000473:pathology; D010026:Osteosclerosis / Q000201:enzymology*; D010257:Paraneoplastic Syndromes / Q000201:enzymology* / Q000473:pathology; D051381:Rats; D013601:T-Lymphocytes
D008222:Lymphokines; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase