title: Adenosine nucleotide utilization in subtotally nephrectomized rabbits.
abstract: Two- to three-kilogram albino rabbits were subtotally nephrectomized and compared with sham-operated normal rabbits for the muscle content of adenosine mono (AMP)-, di (ADP)- and triphosphate (ATP) and inosine monophosphate (IMP) before and after exercise. Analysis of snap-frozen, lyophilized soleus muscle showed lower levels of AMP, ATP and total adenosine nucleotide (TAN) (p less than 0.01) and ATP/ADP (p less than 0.02) in the subtotally nephrectomized animals. IMP levels following exercise were higher in the experimental animals. Muscle adenosine nucleotide concentrations in the experimental animals were significantly different for normals, thus suggesting that minimal azotemia could adversely affect muscle function in these animals.
authors: Department of Medicine, George Washington University Medical Center, Washington, D.C.
authors: A E
authors: AE
authors: Parrish
authors: M
authors: M
authors: Zikria
authors: C
authors: C
authors: Tomaselli
authors: T M
authors: TM
authors: Phillips
authors: R A
authors: RA
authors: Kenney
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000378:metabolism; D009392:Nephrectomy; D005082:Physical Exertion / Q000502:physiology; D011817:Rabbits
chemical_list: D000227:Adenine Nucleotides