Very late activation antigen on synovial fluid T cells from patients with rheumatoid arthritis and other rheumatic diseases.
We used flow cytometry and immunoprecipitation techniques to study the expression of the activation molecules transferrin receptor, interleukin-2 receptor, HLA-DR, and very late activation antigen 1 (VLA-1) on purified T lymphocytes from peripheral blood and synovial fluid of 9 patients with rheumatoid arthritis and 7 patients with other rheumatic diseases. We found a T cell subset bearing VLA-1 in synovial fluid from 8 rheumatoid arthritis patients and 4 patients with other rheumatic diseases. VLA-1 was not found in peripheral blood T lymphocytes from either group.
Laffon
A
A
Section of Rheumatology, Hospital de la Princesa, Universidad Autónoma de Madrid, Spain.
Sánchez-Madrid
F
F
Ortíz de Landázuri
M
M
Jiménez Cuesta
A
A
Ariza
A
A
Ossorio
C
C
Sabando
P
P
D000943:Antigens, Differentiation / Q000502:physiology*; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D005453:Fluorescence; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D016029:Receptors, Very Late Antigen; D012216:Rheumatic Diseases / Q000276:immunology* / Q000473:pathology; D013582:Synovial Fluid / Q000166:cytology* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000943:Antigens, Differentiation; D006684:HLA-DR Antigens; D016029:Receptors, Very Late Antigen