[The effect of urea on epidermal cell renewal measured with a noninvasive method].
On five subjects (2 women and 3 men) the penetration-promoting and cell division-blocking effect of 10% urea was measured and compared to that of the ointment base and a commercially available preparation (containing 10% urea, 5% lactic acid, and 4.3% betaine = ULB cream). The dansylchloride fluorescence detection technique coupled with quantitative evaluation on the lower arm was applied. Only ULB cream promoted penetration as early as day 3 and significantly increased fluorescence by day 6 as compared with controls.
Baló-Banga
J M
JM
Klinik f. Haut- und Geschlechtskrankheiten, Semmelweis Universität, Budapest.
D000328:Adult; D002455:Cell Division / Q000187:drug effects*; D004261:DNA Replication / Q000187:drug effects; D003879:Dermatologic Agents / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D012867:Skin / Q000187:drug effects*; D014508:Urea / Q000494:pharmacology*
D003879:Dermatologic Agents; D014508:Urea
Harnstoff-Einfluss auf die epidermale Zellerneuerung gemessen mit einer nichtinvasiven Methode.