IgE antibody to sweat in atopic dermatitis.
Of 45 patients with atopic dermatitis skin-tested with their own sweat, 43 showed positive immediate-type skin reactions to titres between 1 and 256. Of 22 non-atopic patients 18 showed negative reactions. Skin reactivity of the atopic patients to the sweat and house dust did not run parallel. Radioallergosorbent test (RAST) using the sweat collected from a healthy subject detected IgE antibody in 24 atopic patients with a score from 0.5 to 3.5, whereas all the control subjects showed the score 0. This IgE antibody to sweat did not cross-react with the mite extract (Dermatophagoides farinae) or Staphylococcus aureus. These results indicate that atopic patients have specific IgE antibody to sweat.
Adachi
K
K
Department of Dermatology, Habikino Hospital of Osaka Prefecture, Japan.
Aoki
T
T
D000293:Adolescent; D000328:Adult; D002648:Child; D003876:Dermatitis, Atopic / Q000276:immunology*; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011852:Radioallergosorbent Test; D011864:Radioimmunosorbent Test; D012871:Skin Diseases / Q000276:immunology; D012882:Skin Tests; D013542:Sweat / Q000276:immunology*
D007073:Immunoglobulin E