title: Effects of anticholinergic agents on the excitability of the blink reflex in Meige syndrome.
abstract: Blink reflex recovery cycle, before and after acute administration of orphenadrine chlorhydrate, was tested in Meige syndrome. Data here reported show, after the drug, a decrease of the unconditioned polysynaptic responses, without a significant modification of the blink reflex recovery curves. This fact rules out a specific effect of anticholinergic drugs on the pathological reduction of the inhibitory process, at an interneuronal level of these polysynaptic pathways, in Meige syndrome.
authors: Institute of Clinical Neurology, University of Pisa, Italy.
authors: B
authors: B
authors: Rossi
authors: G
authors: G
authors: Vignocchi
authors: G
authors: G
authors: Siciliano
authors: R
authors: R
authors: Risaliti
mesh_terms: D000368:Aged; D001480:Basal Ganglia Diseases / Q000503:physiopathology*; D001767:Blinking / Q000187:drug effects*; D005260:Female; D006801:Humans; D008538:Meige Syndrome / Q000503:physiopathology*; D008875:Middle Aged; D009966:Orphenadrine / Q000494:pharmacology*; D010276:Parasympatholytics / Q000494:pharmacology*
chemical_list: D010276:Parasympatholytics; D009966:Orphenadrine