Cardiac peroxisomal enzymes and starvation.
In mice subjected to 3-day periods of food deprivation an increase in plasma free fatty acids occurred together with a rise in the cardiac content of fatty acyl CoA-oxidase (+ 15.2%) and catalase (+ 136.2%) activities. Stimulation of hydrogen peroxide production by the heart was found after 30 hours of fasting and this phenomenon was almost completely eliminated by 6 hours of refeeding. These data suggest that high myocardial loads of free fatty acids involve the peroxisomal enzymes in the beta-oxidation process. The resulting increase in hydrogen peroxide production could be partly responsible for the myocardial injury caused by starvation.
Crescimanno
M
M
Istituto di Farmacologia e Sezione Autonoma di Oncologia Clinica, Palermo, Italy.
Armata
M G
MG
Rausa
L
L
Gueli
M C
MC
Nicotra
C
C
D'Alessandro
N
N
D042962:Acyl-CoA Oxidase; D000818:Animals; D002374:Catalase / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006861:Hydrogen Peroxide / Q000378:metabolism; D051379:Mice; D008830:Microbodies / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology* / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D013217:Starvation / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D006861:Hydrogen Peroxide; D010088:Oxidoreductases; D002374:Catalase; D042962:Acyl-CoA Oxidase