Significance tests for cancer screening trials.
The goal of a cancer screening program is to reduce cancer mortality by detecting tumors at earlier stages of their development. For some types of cancer, screening tests may allow the preclinical detection of benign precursors of a tumor, and thus a screening program could result in reductions in both cancer incidence and mortality. For other types of cancer, a screening program will not reduce cancer incidence, and thus the expected outcome in a randomized cancer screening trial would be equal cancer incidence rates in control and study groups, but reduced cancer mortality in the study group. For the latter situation, we employ a variety of Poisson models for cancer incidence and mortality to derive optimal tests for equality of cancer mortality rates in a cancer screening trial, and we compare the asymptotic relative efficiencies of the test statistics under various alternatives. We demonstrate that testing equality of case mortality rates using Fisher's exact test or its Pearson chi-square approximation is nearly optimal when cancer incidence rates are equal and is fully efficient when cancer incidence rates are unequal. When valid, this comparison of case mortality rates in the study and control groups can be considerably more powerful than the standard comparison of population mortality rates. We illustrate the results using data from a clinical trial of a breast cancer screening program.
Tarone
R E
RE
Mathematical Statistics and Applied Mathematics Section, National Cancer Institute, Bethesda, Maryland 20892.
Gart
J J
JJ
D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000517:prevention & control; D005260:Female; D006801:Humans; D008403:Mass Screening; D008433:Mathematics; D008875:Middle Aged; D015233:Models, Statistical; D009010:Monte Carlo Method; D009369:Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000517:prevention & control*; D011336:Probability