Effect of parathyroid hormone, centrally or peripherally injected, on gastric activity in male rats.
Parathyroid hormone (PTH) injected peripherally did not interfere with the development of experimental ulcers. Conversely, when PTH was administered i.c.v. the development of ulcers was significantly inhibited. The gastric secretory volume and acid output were also reduced. The possibility is discussed that this antisecretory activity of PTH may be due to a direct effect at the CNS level.
Clementi
G
G
Institute of Pharmacology, Department of Internal Medicine, University of Catania School of Medicine, Italy.
Caruso
A
A
Fiore
C E
CE
Leone
M G
MG
Prato
A
A
D000818:Animals; D000431:Ethanol; D005744:Gastric Acid / Q000378:metabolism; D007213:Indomethacin; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D010281:Parathyroid Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D011708:Pylorus / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013270:Stomach / Q000187:drug effects*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology; D013315:Stress, Psychological / Q000150:complications
D010281:Parathyroid Hormone; D000431:Ethanol; D007213:Indomethacin