[Structure-activity relations of antineoplastic platinum II and platinum IV coordination compounds].
Five diammine-Pt(II) or Pt(IV) coordination compounds, namely cis-diammine-dichloro-platinum (II) "cis-DDP", transdihydroxy-cis-diammine-dichloro-platinum (IV) "trans-ODDP", and derived substitution products of lactic acid (racemates or L-forms) with diminished toxicity in comparison to cis-DDP have been tested against mouse leukemia P388, and partly on melanoma B16 for antineoplastic activity. The results have been compared with those obtained with the clinical approved cis-DDP. They were not in every way equal to the antitumor efficiency of cis-DDP. Improved physicochemical properties as well as favorable differences of side effects in contrast to cis-DDP, could be decisive for the potential value of these substances.
Gutsche
W
W
Zentralinstitut für Mikrobiologie und experimentelle Therapie, Akademie der Wissenschaften der DDR, Jena.
Baumgart
J
J
Schröer
H P
HP
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D007274:Injections, Intraperitoneal; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C061259:diammine platinum(II) dilactate; C061258:diammine platinum(II) lactate; D002945:Cisplatin; C043804:diamminedichlorodihydroxyplatinum IV
Struktur-Wirkungsbeziehungen antineoplastisch wirksamer Koordinationsverbindungen des II- und IV-wertigen Platins.