Propofol-induced anaesthesia. Double-blind comparison of recovery after anaesthesia induced by propofol or thiopentone.
Postoperative psychomotor and cognitive recovery were assessed after anaesthesia induced by either propofol or thiopentone, and maintained with nitrous oxide and halothane in 40 unpremedicated dental patients. Performance was shown to be impaired one hour postoperatively for the whole sample in hand-eye coordination (p less than 0.001), reaction time (p less than 0.001) and digit span (p less than 0.05). There was evidence of impairment at 3 hours postoperatively in reaction time (p less than 0.05) and ataxia (p less than 0.01). Performance also deteriorated in the dexterity and aiming tasks. Patients reported significantly less clumsiness by 24 hours in blurred vision and shivering (p less than 0.05) and by 48 hours less coughing (p less than 0.05). However, there was no significant difference between groups. No evidence showed that recovery in the propofol group was faster, so it was concluded that induction with propofol offered no advantage when anaesthesia is maintained with nitrous oxide and halothane for the periods of time reported in this study.
Sanders
L D
LD
Department of Anaesthesia, University of Wales, College of Medicine, Heath Park, Cardiff.
Isaac
P A
PA
Yeomans
W A
WA
Clyburn
P A
PA
Rosen
M
M
Robinson
J O
JO
D000293:Adolescent; D000328:Adult; D000368:Aged; D000762:Anesthesia Recovery Period; D000766:Anesthesia, Dental; D000777:Anesthetics; D003071:Cognition / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006221:Halothane; D006801:Humans; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D010636:Phenols / Q000494:pharmacology; D015742:Propofol; D011597:Psychomotor Performance / Q000187:drug effects; D013874:Thiopental / Q000494:pharmacology
D000777:Anesthetics; D010636:Phenols; D013874:Thiopental; D009609:Nitrous Oxide; D006221:Halothane; D015742:Propofol