title: [Double minute chromosomes (DMs) in a case of acute myelomonocytic leukemia].
abstract: A 71-year old male was admitted to our hospital because of general malaise and fever. Peripheral blood showed Hb 8.1 g/dl, platelet 7.0 X 10(4)/microliters, and WBC 18.100/microliters with 64% leukemic cells. Bone marrow showed normocellularity with 73.4% leukemic cells. They were positive for peroxidase and alpha-naphthyl butyrate esterase stainings. Serum and urine lysozyme levels were elevated. He was diagnosed as having acute myelomonocytic leukemia (M 4 in FAB classification). Chromosome analysis of bone marrow cells showed 45, XY, -17, t (9; 17) (q22; p13) and double minute chromosomes (DMs) were observed in the 50 cells analyzed. A complete remission (CR) was obtained by DCMP regimen, but he relapsed as acute monocytic leukemia (M 5 b in FAB classification) and died 5 months after diagnosis. DMs appear to be rare in acute leukemia and the clinical and etiologic implications of DMs are discussed.
authors: T
authors: T
authors: Takesako
authors: S
authors: S
authors: Murakami
authors: H
authors: H
authors: Haruyama
authors: N
authors: N
authors: Oku
authors: N
authors: N
authors: Takeda
authors: K
authors: K
authors: Itoh
authors: N
authors: N
authors: Fujita
authors: S
authors: S
authors: Nakanish
authors: C
authors: C
authors: Shimazaki
authors: T
authors: T
authors: Isemura
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D006801:Humans; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D008297:Male