Theme and variations on a string of amyloid.
In vivo amyloidogenesis seems to involve glycosaminoglycans. The latter may be especially important in their interactions with amyloid precursors. Glycosaminoglycans may influence both the folding of and amyloid precursors. Glycosaminoglycans may influence both the folding of and proteolytic attack on such precursors, and one may speculate that proteolysis is an after-event in amyloid fibril formation.
Kisilevsky
R
R
Department of Pathology, Queen's University, Kingston, Ontario, Canada.
D000544:Alzheimer Disease / Q000378:metabolism*; D000686:Amyloidosis / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism*; D006801:Humans
D006025:Glycosaminoglycans