Effect of antioxidant enzymes on experimental uveitis in rats.
The antioxidant enzymes superoxide dismutase and glutathione peroxidase have been observed to be effective antiphlogistic agents in severe experimental allergic uveitis induced by retinal S antigen in rats. The role that the high concentration of antioxidants found in the eye may play in modulating acute inflammation is discussed.
de Kozak
Y
Y
Unité de Recherche d'Ophtalmologie, Paris, France.
Nordman
J P
JP
Faure
J P
JP
Rao
N A
NA
Marak
G E
GE
D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D019393:Arrestin; D002829:Choroid / Q000473:pathology; D005136:Eye Proteins / Q000008:administration & dosage; D005979:Glutathione Peroxidase / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D051381:Rats; D011917:Rats, Inbred Lew; D012164:Retinal Diseases / Q000473:pathology; D013482:Superoxide Dismutase / Q000627:therapeutic use*; D014603:Uveal Diseases / Q000473:pathology; D014605:Uveitis / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*
D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase