Negative micronucleus tests on caprolactam and benzoin in ICR/JCL male mice.
Male ICR/JCL mice were given a single intraperitoneal injection of 125, 250, and 500 mg/kg of caprolactam (CAP), or 250, 500, and 1000 mg/kg of benzoin (ZOIN). Bone marrow preparations were made 24, 30, and 48 h after treatment with the maximum dose, and 30 h after treatment with the other doses. The slides were coded before microscopic examination. No significant increase was found in the incidence of micronucleated polychromatic erythrocytes after treatment with either CAP or ZOIN.
Ishidate
M
M
National Institute of Hygienic Sciences, Tokyo, Japan.
Odagiri
Y
Y
D000818:Animals; D001381:Azepines / Q000633:toxicity*; D001573:Benzoin / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects; D002209:Caprolactam / Q000633:toxicity*; D004912:Erythrocytes / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009153:Mutagens
D001381:Azepines; D009153:Mutagens; D002209:Caprolactam; D001573:Benzoin