Brain single photon emission computed tomography in neonates.
This study was designed to rate the clinical value of [123I]iodoamphetamine (IMP) or [99mTc] hexamethyl propylene amine oxyme (HM-PAO) brain single photon emission computed tomography (SPECT) in neonates, especially in those likely to develop cerebral palsy. The results showed that SPECT abnormalities were congruent in most cases with structural lesions demonstrated by ultrasonography. However, mild bilateral ventricular dilatation and bilateral subependymal porencephalic cysts diagnosed by ultrasound were not associated with an abnormal SPECT finding. In contrast, some cortical periventricular and sylvian lesions and all the parasagittal lesions well visualized in SPECT studies were not diagnosed by ultrasound scans. In neonates with subependymal and/or intraventricular hemorrhage the existence of a parenchymal abnormality was only diagnosed by SPECT. These results indicate that [123I]IMP or [99mTc]HM-PAO brain SPECT shows a potential clinical value as the neurodevelopmental outcome is clearly related to the site, the extent, and the number of cerebral lesions. Long-term clinical follow-up is, however, mandatory in order to define which SPECT abnormality is associated with neurologic deficit.
Denays
R
R
Department of Neurology, St Pierre Hospital, Free Universities of Brussels, Belgium.
Van Pachterbeke
T
T
Tondeur
M
M
Spehl
M
M
Toppet
V
V
Ham
H
H
Piepsz
A
A
Rubinstein
M
M
Noël
P
P
Haumont
D
D
D000662:Amphetamines; D001238:Asphyxia Neonatorum / Q000000981:diagnostic imaging; D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D008297:Male; D009122:Muscle Hypertonia / Q000000981:diagnostic imaging; D009123:Muscle Hypotonia / Q000000981:diagnostic imaging; D009942:Organometallic Compounds; D010091:Oximes; D012640:Seizures / Q000000981:diagnostic imaging; D013667:Technetium; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed
D000662:Amphetamines; D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D013667:Technetium