title: Analyses of chromium and nickel in human pulmonary tissue. Investigations in lung cancer patients and a control population under special consideration of medical expertise aspects.
abstract: After inhalative occupational exposure to certain compounds containing nickel and chromium (mostly over many years), an accumulation of these metals may occur in the lung tissue. This is of particular importance, both from a toxicological point of view and with regard to expert reports, since certain nickel and chromium compounds may induce lung cancers. In the context of this study, samples of pulmonary tissue from 34 deceased persons from the Bergen area (Norway) were analysed by atomic absorption spectrometry with regard to their content of chromium and nickel. The deceased comprised 21 men and 13 women. In 15 cases, death resulted from lung cancer; in the other 19 deceased, there was no indication of a malignant disease of the airways. The concentrations of nickel found in the lung tissue do not differ between patients with lung cancer and patients with healthy lungs. On the other hand, the concentration of chromium in the pulmonary tissue in the patients who had died of lung cancer and who had all been inhalative smokers, are higher (statistically significant) than in the nonsmokers or in those with healthy lungs. An accumulation of these two metals in the tumor matrix could not be detected. Both the average nickel and the average chromium concentrations were higher in the persons who had probably been exposed occupationally. Considering the present state of scientific knowledge, the aspects relevant to expert reports which result from the analyses of metals in the pulmonary tissue are discussed.
authors: Institute of Occupational and Social Medicine, University of Erlangen-Nuremberg, FRG.
authors: H J
authors: HJ
authors: Raithel
authors: K H
authors: KH
authors: Schaller
authors: L A
authors: LA
authors: Akslen
authors: A O
authors: AO
authors: Myking
authors: O
authors: O
authors: Mørkve
authors: A
authors: A
authors: Gulsvik
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002857:Chromium / Q000032:analysis*; D005260:Female; D006801:Humans; D008168:Lung / Q000032:analysis*; D008175:Lung Neoplasms / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000032:analysis*
chemical_list: D002857:Chromium; D009532:Nickel