Direct cytogenetic analysis of primary neuroblastoma.
In this paper the results of cytogenetic analysis of a metastatic neuroblastoma from a 14-month-old boy are described. Direct cytogenetic analysis was performed on tumor pieces obtained from surgery prior to therapy. Consistent numerical and structural chromosome aberrations were identified. The modal chromosome number was 48, with 9.4% of the cell population being in the near-tetraploid range. In all karyotyped cells, the Y chromosome was missing and additions of chromosomes 7 and 14 were identified. Two rearranged #1 were observed: del(1)(p22 or p31) and t(1;18)(p22 or p31;q11-12), resulting in monosomy of the distal segment of the short arm and trisomy of the long arm. In two cells, single minutes were found; this chromosomal aberration has been previously described in a case of metastatic neuroblastoma.
Petković
I
I
Institut for Mother and Child Health, Zagreb, Yugoslavia.
Nakić
M
M
Cepulić
M
M
D002869:Chromosome Aberrations; D002871:Chromosome Banding; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D009447:Neuroblastoma / Q000235:genetics*