Ontogenesis of monoamine oxidase-A and -B in the human brain frontal cortex.
The effect of several antemortem and postmortem factors (patients' age, sex, postmortem delay, storage time, laterality and brain weight) on both monoamine oxidase-A (MAO-A) and -B (MAO-B) activity was investigated in the frontal cortex of human brains. The MAO-A activity decreases rapidly during the first two years of life and remains constant thereafter. In contrast, the MAO-B activity keeps unchanged during early childhood and raises during advanced age. These findings seem to be consistent with a genetic regulation and a variation in cell type assembling during brain development and aging.
Kornhuber
J
J
Department of Psychiatry, University of Würzburg, F.R.G.
Konradi
C
C
Mack-Burkhardt
F
F
Riederer
P
P
Heinsen
H
H
Beckmann
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005625:Frontal Lobe / Q000201:enzymology* / Q000254:growth & development; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000378:metabolism* / Q000502:physiology
D008995:Monoamine Oxidase