[Non-granulomatous anterior uveitis and HLA-B27 antigen].
In Caucasians, there is close correlation between acute anterior uveitis and histocompatibility antigen HLA-B27. But in Japanese, this is not clear. Therefore, we examined 58 patients with non-granulomatous anterior uveitis (NGAU) about HLA typing in our uveitis clinic at Tokyo Women's Medical College Hospital. HLA-B27 was identified in 20 out of 58 patients (34.5%) with NGAU and it was statistically significant. We also studied the clinical features of patients with HLA-B27 positive NGAU. We found that in HLA-B27-positive NGAU, the visual acuity was more strongly affected during the attack and the duration of inflammation was longer than HLA-B27 negative NGAU patients. The duration of the first attack was longer than re-attack, and the duration of the first attack was longer than HLA-B27 negative NGAU patients. It was less commonly associated with systemic disorders in Japanese HLA-B27 positive anterior uveitis than in Caucasian. However, in Japanese NGAU patients without systemic disorders, there was the same tendency concerning the HLA-B27 positive rate as in Caucasians.
Fukuda
S
S
Kogure
M
M
Shimakawa
M
M
Wakatsuki
Y
Y
Takahashi
Y
Y
Ohsone
T
T
Oguro
Y
Y
Kanai
K
K
Kuranami
T
T
D044466:Asian People / Q000235:genetics; D015796:HLA-B27 Antigen / Q000032:analysis* / Q000235:genetics; D006801:Humans; D007564:Japan; D014606:Uveitis, Anterior / Q000276:immunology*; D044465:White People / Q000235:genetics
D015796:HLA-B27 Antigen