The role of class II major histocompatibility complex antigens in autoimmune diabetes: animal models.
Like human insulin-dependent diabetes, autoimmune diabetes in BB rats and NOD mice is under control of Class II genes of the major histocompatibility complex. The mechanisms of expression of these genes is still unclear. No aberrant expression of Class II antigens was found in BB rats at the onset of diabetes. The putative role of inadequate Class II-linked suppressor control is suggested, however, by the observation that in vivo treatment with anti-Class II monoclonal antibody prevents the onset of diabetes in NOD mice, and that this protection can be transfer by CD4+ T cells.
Timsit
J
J
Institut National de le Santé et la Recherche Médicale, Unité 25 Hôpital Necker, Paris, France.
Savino
W
W
Boitard
C
C
Bach
J F
JF
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D003921:Diabetes Mellitus, Experimental / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D004195:Disease Models, Animal; D000949:Histocompatibility Antigens Class II; D007116:Immunization, Passive; D008297:Male; D051379:Mice; D010179:Pancreas / Q000276:immunology / Q000473:pathology; D051381:Rats; D011913:Rats, Inbred BB; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II