[Hematopoietic precursor cells in Wistar rats with acute myeloblastic leukemia].
The studies were performed on Wistar rats with acute myeloblastic leukemia induced by a prolonged administration of tritiated water (370 MBq/kg/day-1; an absorbed dose--25.3 Gy) and by repeated pyrogenal injections. A reduction of the pool of polypotent hemopoietic cells (CFUs) with a simultaneous increase of their proliferative activity and a decline of their ability to self-supporting were observed in the leukemia-bearing animals. Populations of CFUdc in DC and of CFUc were reduced in all cases; their colony-forming ability was also found to decrease. All animals with leukemia showed a lowered amount of CFU-BL in the bone marrow and of CFU-TL in the thymus, although the content of these cells in the peripheral blood remained unchanged.
Muksinova
K N
KN
Murzina
L D
LD
Kirillova
E N
EN
Revina
V S
VS
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D006098:Granulocytes / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000473:pathology*; D007953:Leukemia, Radiation-Induced / Q000209:etiology / Q000473:pathology*; D008070:Lipopolysaccharides; D009000:Monocytes / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D011749:Pyrogens; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D013997:Time Factors; D014316:Tritium; D014867:Water
D008070:Lipopolysaccharides; D011749:Pyrogens; C009136:pyrogenal; D014867:Water; D014316:Tritium; C033961:tritium oxide
Krovetvornye kletki-predshestvenniki u krys porody Wistar s ostrym mieloblastnym leĭkozom.