title: Atrophic rhinitis in New Zealand white rabbits infected with Pasteurella multocida.
abstract: Atrophic rhinitis was detected in New Zealand White rabbits when upper respiratory tract disease was evaluated during a vaccine field trial for the prevention of pasteurellosis. Of 52 adult rabbits euthanatized and necropsied, 26 (50%) had evidence of turbinate atrophy. Atrophy was detected in 77% of rabbits with Pasteurella multocida infection only, 71% of rabbits with concurrent P multocida and Bordetella bronchiseptica infections, and 6% of rabbits with B bronchiseptica infection only. Grossly, turbinate atrophy was characterized by a mild to severe loss or diminution in the maxilloturbinates. Histologically, turbinate bones were small and irregular in thickness and had numerous osteoclasts and osteoblasts. A neutrophilic exudate filled the nasal passages, and infiltrates of neutrophils and lymphocytes were detected in the mucosa and submucosa of the nasal turbinates. Rhinitis was significantly (P less than 0.001) associated with turbinate atrophy. Isolates of P multocida from rabbits with turbinate atrophy were serotype A:12.
authors: Department of Comparative Medicine, School of Medicine, University of Washington, Seattle 98195.
authors: R F
authors: RF
authors: DiGiacomo
authors: B J
authors: BJ
authors: Deeb
authors: W E
authors: WE
authors: Giddens
authors: B L
authors: BL
authors: Bernard
authors: M M
authors: MM
authors: Chengappa
mesh_terms: D000818:Animals; D001284:Atrophy / Q000662:veterinary; D001885:Bordetella Infections / Q000150:complications / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D005260:Female; D010325:Pasteurella / Q000302:isolation & purification; D010326:Pasteurella Infections / Q000150:complications / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D011817:Rabbits / Q000382:microbiology*; D012141:Respiratory Tract Infections / Q000150:complications / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D012222:Rhinitis, Atrophic / Q000150:complications / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D014420:Turbinates / Q000473:pathology*