Hyaluronan in flexor tendon repair.
This study assesses the effect of a preparation of hyaluronan (hyaluronic acid) applied topically at the time of flexor tendon repair in a well-established model. The hypothesis is that hyaluronic acid applied topically at the time of flexor tendon repair will decrease adhesions, and will improve clinically the gliding function of the repaired flexor tendon. After transection and repair of the second and fifth flexor tendons of the left forepaw of four mongrel dogs, the second flexor tendon was treated with hyaluronic acid of molecular weight 3.6 x 10(6) daltons applied topically between the synovial sheath and the repair site. The left forepaws were completely immobilized for 5 weeks to optimize the formation of adhesion ingrowth. After death, the repaired tendons and sheaths were removed en bloc, fixed, and dissected. Gross inspection and histologic evaluation of all tendons showed that the quality and quantity of adhesions from the wound repair to the synovial sheath appeared to have been consistently affected by hyaluronan. Hyaluronic acid had a beneficial effect on both the repair site and synovial sheath by decreasing the peripheral inflammatory response and promoting a contact healing process via epitenon and endotenon cell involvement in the repair process.
Amiel
D
D
University of California, San Diego, La Jolla 92093.
Ishizue
K
K
Billings
E
E
Wiig
M
M
Vande Berg
J
J
Akeson
W H
WH
Gelberman
R
R
D000818:Animals; D004285:Dogs; D005552:Forelimb; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007103:Immobilization; D008722:Methods; D013710:Tendons / Q000473:pathology / Q000601:surgery*; D000267:Tissue Adhesions; D014034:Toes / Q000601:surgery*
D006820:Hyaluronic Acid