Will neurotrophic agents be harmful in Alzheimer's disease?
The thesis that neurotrophic therapy in Alzheimer's disease may exacerbate the pathological state merits careful experimental verification. We are concerned about prematurely dismissing an important avenue of potential therapy which would provide a trophic stimulus to compensate for enhanced proteolysis and the deposition of A4 amyloid peptide.
Appel
S H
SH
Department of Neurology, Baylor College of Medicine, Houston, TX.
McManaman
J L
JL
Strittmatter
W J
WJ
D000544:Alzheimer Disease / Q000188:drug therapy*; D006801:Humans; D009414:Nerve Growth Factors / Q000627:therapeutic use*
D009414:Nerve Growth Factors