title: In vivo protein phosphorylation in Drosophila mutants defective in learning and memory.
abstract: Polypeptides phosphorylated in vivo in Drosophila mutants defective in learning and memory, were characterized by polyacrylamide gel electrophoresis of subcellular fractions obtained by phase partitioning in Triton X-114 [3]. In the mutants turnip, dunce and Shaker, one or more bands at a molecular weight range of 50-80 kDa had altered 32P incorporation. Some of these bands were altered in more than one mutant. In the mutant rutabaga no significant differences from wild-type were observed. The data suggest that phosphoproteins that could be potentially related to learning mechanisms might be identified in some learning mutants.
authors: Weizmann Institute of Science, Department of Neurobiology, Rehovot, Israel.
authors: J D
authors: JD
authors: Buxbaum
authors: Y
authors: Y
authors: Dudai
mesh_terms: D000818:Animals; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D008970:Molecular Weight; D009154:Mutation; D010750:Phosphoproteins / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation
chemical_list: D010750:Phosphoproteins