title: [Resorption and postoperative anti-inflammatory effect of soluble indomethacin eyedrops].
abstract: Absorption of the 0.3% Indomethacin-soluble ophthalmic solution produced in the 2nd Department of Ophthalmology in Budapest is more rapid and reaches a higher concentration in the aqueous humour than 0.5% Indomelol or 1.0% Indoptol ophthalmic solution. This fact was demonstrated in human aqueous humour, too, taken from the eye 1 h after administration of the drops at the beginning of the cataract operation. The Indomethacin-soluble eye drops are especially effective in preventing a postoperative increase in the intraocular pressure as a result of inflammation. On the first postoperative day following the cataract operation a 26.2% increase in the intraocular pressure in was found in the patients. In eyes treated with Indomethacin this number was 14.0%. The difference is significant (p = 0.04).
authors: G
authors: G
authors: Imre
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D009877:Endophthalmitis / Q000517:prevention & control; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009883:Ophthalmic Solutions; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D011817:Rabbits
chemical_list: D009883:Ophthalmic Solutions; D007213:Indomethacin
vernacular_title: Resorption und postoperative anti-inflammatorische Wirkung von "Indomethacin soluble"-Augentropfen.