[Kleine-Levin syndrome. The provocation of manic symptoms by an antidepressant and a therapeutic trial of carbamazepine].
A 17-year-old adolescent had a recurrent episode of somnolence and morbid hunger (Kleine-Levin syndrome) three years after a first attack, from which he had spontaneously recovered. He was treated with 50 mg daily of clomipramine for the somnolence accompanied by disturbance of attention and memory. Under this treatment he developed thymoleptic symptoms with polyphagia, logorrhea and hyperactivity. Placed on a trial dose of at first 600 mg, then 400 mg carbamazepine daily the abnormal findings disappeared within a few days, and there has been no recurrence after some months. It is postulated, based on the observations of this case, that the Kleine-Levin syndrome, presumably a functional hypothalamic disorder, is closely related to the endogenous psychoses.
Wurthmann
C
C
Neurologische Klinik, Universität Düsseldorf.
Hartung
H P
HP
Dengler
W
W
Gerhardt
P
P
D000293:Adolescent; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000188:drug therapy / Q000523:psychology; D002220:Carbamazepine / Q000008:administration & dosage / Q000627:therapeutic use*; D002997:Clomipramine / Q000008:administration & dosage / Q000009:adverse effects*; D006970:Disorders of Excessive Somnolence / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D004341:Drug Evaluation; D001068:Feeding and Eating Disorders / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D006801:Humans; D008297:Male; D011599:Psychopathology; D012008:Recurrence; D012075:Remission, Spontaneous; D012893:Sleep Wake Disorders / Q000150:complications*; D013577:Syndrome
D002220:Carbamazepine; D002997:Clomipramine
Kleine-Levin-Syndrom. Provokation manischer Symptome durch ein Antidepressivum und Therapieversuch mit Carbamazepin.