Splenic accumulation of interleukin-3-dependent hematopoietic cells in Friend erythroleukemia.
Interleukin-3-dependent hematopoietic stem cells commonly accumulate in spleens of mice infected with leukemia viruses. To study their origins, a molecularly tagged helper-free Friend spleen focus-forming virus was used to produce erythroleukemias. Uninfected interleukin-3-dependent basophil-mast cell progenitors coproliferated amidst the spleen focus-forming virus-infected leukemic cells. Splenic proliferation of normal stem cells is apparently a host response to leukemogenesis, and we propose that it may contribute to certain retroviral diseases.
Spiro
C
C
Department of Biochemistry, School of Medicine, Oregon Health Sciences University, Portland 97201-3098.
Gliniak
B C
BC
Kabat
D
D
D000818:Animals; D002455:Cell Division; D005622:Friend murine leukemia virus; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D007377:Interleukin-3 / Q000494:pharmacology*; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology*; D051379:Mice; D013154:Spleen / Q000473:pathology*
D007377:Interleukin-3