Chronic glomerulonephritis: inflammatory mediators stimulate the collagen synthesis in glomerular epithelial cells.
C5b-9 membrane attack complexes of complement (MAC) stimulate the production of type IV collagen in cultures of human glomerular epithelial cells. Together with other known effects of MAC interaction with glomerular cells, the complex is ascribed a role in the progress of acute glomerulitis into the chronic nephritic state.
Hänsch
G M
GM
Institute of Immunology, University of Heidelberg, FRG.
Torbohm
I
I
Rother
K
K
D002478:Cells, Cultured; D003094:Collagen / Q000378:metabolism*; D015938:Complement Membrane Attack Complex; D003165:Complement System Proteins / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004848:Epithelium / Q000378:metabolism; D005921:Glomerulonephritis / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis; D008970:Molecular Weight
D015938:Complement Membrane Attack Complex; D007375:Interleukin-1; D003094:Collagen; D003165:Complement System Proteins