Screening for mitochondrial cytopathies: the sub-anaerobic threshold exercise test (SATET).
A simple test is described for identifying patients with abnormalities of muscle energy metabolism secondary to mitochondrial dysfunction, based on the venous lactate response to exercise at 90% of predicted work rate at the anaerobic threshold. The test was standardised for age, weight and sex of subjects, and was abnormal in all cases of mitochondrial cytopathy tested, with a false positive rate of 7% in a control population. The test was abnormal in two cases of mitochondrial disease in which muscle biopsy was normal or showed only non-specific changes.
Nashef
L
L
Regional Neurosciences Centre, Charing Cross Hospital, London.
Lane
R J
RJ
D000328:Adult; D000368:Aged; D015308:Anaerobic Threshold; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D008659:Metabolic Diseases / Q000175:diagnosis* / Q000378:metabolism; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology*; D005082:Physical Exertion
D007773:Lactates; D019344:Lactic Acid