Melanin concentrating hormone. III. Melanin concentrating hormone (MCH): the message sequence.
Melanin concentrating hormone (MCH) is a heptadecapeptide synthesized by the hypothalamus and secreted by the neurohypophysis of the teleost pituitary gland. MCH stimulates melanosome aggregation within teleost melanocytes but also exhibits MSH-like (melanosome dispersing) activity on tetrapod (frog and lizard) melanocytes. We have synthesized a number of MCH analogues to determine the essential features of the primary structure necessary to stimulate either melanosome aggregation or dispersion in fish or tetrapod melanocytes, respectively. An analysis of the potencies and actions of these analogues on vertebrate melanocytes is provided and demonstrates that the two activities have different structural requirements.
Castrucci
A M
AM
Department of Anatomy and Chemistry, University of Arizona, Tucson 85721.
Lebl
M
M
Hruby
V J
VJ
Matsunaga
T O
TO
Hadley
M E
ME
D000595:Amino Acid Sequence; D000818:Animals; D001681:Biological Assay; D005399:Fishes; D007028:Hypothalamic Hormones; D008116:Lizards; D008543:Melanins / Q000138:chemical synthesis / Q000494:pharmacology*; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology; D008544:Melanocytes / Q000187:drug effects / Q000648:ultrastructure*; D008969:Molecular Sequence Data; D010907:Pituitary Hormones / Q000138:chemical synthesis / Q000494:pharmacology*; D011487:Protein Conformation; D011894:Rana pipiens; D012867:Skin / Q000648:ultrastructure; D013329:Structure-Activity Relationship
D007028:Hypothalamic Hormones; D008543:Melanins; D010907:Pituitary Hormones; C019463:melanin-concentrating hormone; D009074:Melanocyte-Stimulating Hormones