[Clinical and experimental observations of jinqiancao gao on preventive and therapeutic effects in cholelithiasis].
This paper reports the clinical treatment of 120 patients with cholelithiasis for 2 months with Jinquiancao Gao. The Results showed that the clinical effective rate was 92.5%, among which 29 cases were cured, 42 cases markedly improved and 40 cases ineffective. Animal experiments showed that this medicine can prevent gallstone growth. The gallstone growth rate was 78.5% in the control group and 42.8% in the experimental group (P less than 0.05). The mechanism of the decrease of gallstone growth rate suggests that the said medicine could inhibit the activity of beta-Glucuronidase in the bile, diminish the non-combined bilirubin and prevent the bile from forming bilirubin stones. The result of cultured liver cells in vitro showed that the cholesterol synthesis was markedly inhibited by Jinqiancao Gao. Thus the cholesterol concentration of bile was decreased. These effects in turn prevented the bile from forming cholesterol stones.
Zhang
G S
GS
Li
S Z
SZ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002769:Cholelithiasis / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D042882:Gallstones / Q000188:drug therapy; D005966:Glucuronidase / Q000378:metabolism; D006168:Guinea Pigs; D006500:Hepatic Duct, Common; D006801:Humans; D008297:Male; D008875:Middle Aged
D004365:Drugs, Chinese Herbal; D005966:Glucuronidase