Hemodialysis removal of propafenone.
Propafenone kinetics were studied after intravenous and oral dosing in a patient with end-stage renal disease. Hemodialysis was performed within 10 hours of dosing in order to assess its effects. After intravenous administration of 70 mg propafenone, total-body clearance was 10.5 ml/min/kg before and 10.4 ml/min/kg during hemodialysis. After a single oral dose of 300 mg, clearance was 19.4 ml/min/kg before and 18.9 ml/min/kg during hemodialysis. Bioavailability was 48%.
Burgess
E D
ED
Department of Medicine, University of Calgary, Alberta, Canada.
Duff
H J
HJ
D000284:Administration, Oral; D001682:Biological Availability; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007676:Kidney Failure, Chronic / Q000378:metabolism; D008657:Metabolic Clearance Rate; D011405:Propafenone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006435:Renal Dialysis
D011405:Propafenone