[Stable xenon CT-CBF study with measurement of end-tidal xenon concentration--correction by arterial concentration of xenon].
Non-invasive methods with monitoring end-tidal stable xenon (ETXes) are described for estimating local cerebral blood flow (LCBF) and local partition coefficient (L lambda). 30% of Xes in oxygen was inhaled for 240 sec and exhaled for 160 sec during serial CT scannings after denitrogenation with pure oxygen breathing. During the examination, serial samplings of arterial blood and continuous monitoring of ETXes were performed to determine build up range (A) and build up rate constant (K) of artery. Calculated A and K using the arterial sampling (Aa and Ka, respectively) were compared with the calculated A and K using the continuous monitoring of ETXes (Ae and Ke, respectively) in 109 patients with epilepsy, head trauma, or cerebrovascular diseases. Ae and Ke had significantly positive correlation with Aa and Ka, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Touho
H
H
Department of Neurosurgery, Osaka Neurological Institute, Tayonaka, Japan.
Karasawa
J
J
Shishido
H
H
Yamada
K
K
Yamazaki
Y
Y
Asai
M
M
Kawabata
K
K
Kobayashi
K
K
Kitamura
T
T
Kagawa
M
M
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D002648:Child; D006259:Craniocerebral Trauma / Q000000981:diagnostic imaging / Q000503:physiopathology; D004827:Epilepsy / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012119:Respiration; D013990:Tidal Volume; D014057:Tomography, X-Ray Computed; D014978:Xenon / Q000008:administration & dosage / Q000097:blood
D014978:Xenon