Coulter S Plus STKR histograms detect spurious elevation of leucocyte and platelet counts associated with cryoglobulinaemia.
Abnormalities in the size frequency histogram generated by the Coulter S Plus STKR at room temperature raised the possibility of the presence of a cryoglobulinaemia in a man admitted to the hospital with pneumonia. The leucocyte and platelet counts generated by the Coulter S Plus STKR were higher when counts were done at room temperature than counts done at 37 degrees C. Further investigation of the patient revealed the presence of Non-Hodgkin's Lymphoma which had not been suspected on clinical grounds. The importance of testing samples at 37 degrees C, where an abnormality in the Coulter S Plus STKR histogram has been detected at room temperature, is emphasized.
Pagliuca
A
A
Academic Department of Haematological Medicine, King's College Hospital, Denmark Hill, London, UK.
Hambley
H
H
Mufti
G J
GJ
D000368:Aged; D003449:Cryoglobulinemia / Q000097:blood*; D003450:Cryoglobulins / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007958:Leukocyte Count / Q000295:instrumentation*; D008297:Male; D010976:Platelet Count / Q000295:instrumentation*
D003450:Cryoglobulins; D007074:Immunoglobulin G; D007075:Immunoglobulin M