Meropenem: evidence of lack of proconvulsive tendency in mice.
The proconvulsive tendency of the novel carbapenem, meropenem was compared to that of imipenem, alone and in combination with cilastatin. The potentiation of metrazole-induced convulsions in mice was measured. Both imipenem and imipenem/cilastatin caused significant potentiation of metrazole-induced convulsions at a dose of 200 mg/kg, i.v. In contrast, meropenem (50-400 mg/kg, iv) failed to exhibit any significant potentiation of metrazole-induced seizures.
Patel
J B
JB
ICI Pharmaceuticals Group, ICI Americas Inc., Wilmington, DE 19897.
Giles
R E
RE
D000818:Animals; D015780:Carbapenems / Q000633:toxicity*; D015377:Cilastatin / Q000633:toxicity; D015378:Imipenem / Q000633:toxicity; D008297:Male; D000077731:Meropenem; D051379:Mice; D012640:Seizures / Q000139:chemically induced*; D013845:Thienamycins / Q000633:toxicity*
D015780:Carbapenems; D013845:Thienamycins; D015377:Cilastatin; D015378:Imipenem; D000077731:Meropenem