Lineage relationship between oligodendrocytes and brain macrophages?
Cells which adhere rapidly in vitro were purified from embryonic rat brain and characterized as macrophages. These characterizations rely on (1) phagocytic behaviour, (2) non-specific esterase activity, (3) immunocytochemical criteria such as the detection of CD4, Mac 1 and class II products of the major histocompatibility complex (MHC II). Morphological transformations observed in the cultures and labeling with anti-galactocerebroside (GalC) antibodies suggest a possible transition between brain-macrophagic and oligodendrocytic phenotypes.
Mallat
M
M
Chaire de Neuropharmacologie, INSERM U.114, Collège de France, Paris.
Chamak
B
B
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism; D002455:Cell Division; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology* / Q000378:metabolism; D003342:Corpus Striatum / Q000166:cytology* / Q000378:metabolism; D004622:Embryo, Mammalian; D006649:Histocompatibility Antigens / Q000378:metabolism; D008264:Macrophages / Q000166:cytology* / Q000378:metabolism; D009457:Neuroglia / Q000166:cytology*; D009836:Oligodendroglia / Q000166:cytology* / Q000378:metabolism; D051381:Rats
D000945:Antigens, Differentiation, T-Lymphocyte; D006649:Histocompatibility Antigens