[Endocrine, paracrine and autocrine factors in the maturation and functional development of the testis].
We have studied the specific effects of highly purified pituitary hormones on testicular cell multiplication and differentiation in the immature hypophysectomized rat. LH exhibits multiplicative effects on Leydig cells and, curiously, regressive effects on germ cells. Seminiferous tubules are the main site of action of FSH which induces direct differentiation of Sertoli cells and paracrine effects on germ cells resulting in their multiplication to the pachytene stage (in the absence of androgen). Through interstitium-directed paracrine effects, FSH promotes the differentiation of Leydig cells. Prolactin and lactogenic growth hormones are capable of exerting both differentiative and multiplicative effects on Leydig cells. The purity of the hormone preparations permit to define their specific and direct effects and those mediated by paracrine or autocrine factors synthetized locally under their control. Among these potential factors, we have demonstrated the pituitary-dependent expression of IGF-I, c-myc, c-fos proteins. The purity of the preparations used in this work permits to distinguish clearly the specific and direct effect of each pituitary hormone from those mediated by paracrine or autocrine factors.
Closset
J
J
Dombrowicz
D
D
Vandenbroeck
M
M
Scippo
M L
ML
Igout
A
A
Gothot
A
A
Sente
B
B
Hennen
G
G
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D007016:Hypophysectomy; D008297:Male; D010907:Pituitary Hormones / Q000494:pharmacology*; D051381:Rats; D013002:Somatomedins / Q000378:metabolism; D013737:Testis / Q000166:cytology / Q000187:drug effects*
D010907:Pituitary Hormones; D013002:Somatomedins
Facteurs endocrines, paracrines et autocrines dans la maturation et le développement fonctionnels du testicule.