title: Erdosteine protection against cigarette smoking-induced functional antiprotease deficiency in human bronchiolo-alveolar structures.
abstract: Cigarette smoke reduces the elastase inhibitory capacity (EIC) of alpha 1-antitrypsin by an oxidative process and thus may promote the pathogenetic bases for the development of pulmonary emphysema. The present study was performed with the aim to evaluate the protective activity of erdosteine, a novel thiol derivative endowed with reducing properties, against the functional inactivation of alpha 1-AT induced by smoke. For the purpose, a double-blind study was carried out on 24 healthy smokers divided into two groups orally treated with placebo or erdosteine 900 mg/day for one month. The antigenic and functional alpha 1-AT was measured in bronchoalveolar (BAL) fluids and sera before and shortly after the last treatment. The findings indicate that the loss of EIC of alpha 1-AT in BAL fluids can be partially prevented by pharmacological treatment. In this regard, it is reasonable to hypothesize that the reestablishment of the oxidant-antioxidant balance in favor of the antioxidants would be useful as a therapeutic strategy to arrest or at least delay the emphysematous process.
authors: Teaching School of Respiratory Pathology, University of Cagliari, Italy.
authors: M
authors: M
authors: Vagliasindi
authors: G B
authors: GB
authors: Fregnan
mesh_terms: D000328:Adult; D001980:Bronchi / Q000187:drug effects / Q000201:enzymology*; D001992:Bronchoalveolar Lavage Fluid / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000201:enzymology*; D012907:Smoking / Q000378:metabolism*; D013864:Thioglycolates / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*; D000515:alpha 1-Antitrypsin / Q000097:blood; D019896:alpha 1-Antitrypsin Deficiency
chemical_list: D013864:Thioglycolates; D013876:Thiophenes; D000515:alpha 1-Antitrypsin; C048498:erdosteine