Na+/H+ ion-exchange property of postmortem human gastric mucus. The effects of Campylobacter pylori infection and sucralfate.
The effect of Campylobacter pylori infection and sucralfate treatment on the ion-exchange property of human gastric mucus from 17 human postmortem stomachs was investigated in an in vitro chamber. Of the 10 stomachs not infected with C. pylori mucus from 4 stomachs had a 'normal' Na+/H+ exchange capacity, whereas 6 were without a Na+/H+ exchange capacity. The Na+/H+ exchange capacity of the seven stomachs infected with C. pylori was half that of the four 'normal' uninfected stomachs. Sucralfate significantly improved the Na+/H+ exchange capacity of mucus from C. pylori-infected stomachs and from the uninfected stomachs without Na+/H+ exchange. This study shows that impairment of the Na+/H+ exchange capacity of gastric mucus is associated with C. pylori infection and that sucralfate improves the Na+/H+ exchange capacity of gastric mucus.
Thomsen
L
L
Dept. of Medicine, University of Auckland Medical School, New Zealand.
Tasman-Jones
C
C
Morris
A
A
D000368:Aged; D002169:Campylobacter Infections / Q000473:pathology / Q000503:physiopathology*; D005753:Gastric Mucosa / Q000473:pathology / Q000502:physiology*; D005756:Gastritis / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007474:Ion Exchange; D008875:Middle Aged; D013392:Sucralfate / Q000494:pharmacology*
D013392:Sucralfate