[Studies with temocillin].
This is a report about microbiological investigations with a new Penicillin-derivate. Temocillin is the first beta-lactamase stable Penicillin with an excellent bactericidal effect against almost all clinically important gram-negative aerobic germs. The antibacterial activity of Temocillin was determined against 355 multiresistent Enterobacteriaceae-strains. We ascertained minimal bacteriostatic and the minimal bactericidal concentration with help of macrodilution-test. The ratio of resistant strains amounted to 0.8%. In vitro investigations with the combination Temocillin and Gentamicin (checker-board-technique) showed 91% indifference and 9% addition, respectively, in 35 Enterobacteriaceae-strains, investigated. Resistances against Temocillin and Ampicillin were cultured through subinhibitory concentrations to predict parallel resistances possible.
Crusius
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S
D001437:Bacteriuria / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004755:Enterobacteriaceae / Q000187:drug effects*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000627:therapeutic use*; D011704:Pyelonephritis / Q000188:drug therapy
D010406:Penicillins; C031367:temocillin
Untersuchungen mit Temocillin.