Amino acid sequence templates derived from recurrent turn motifs in proteins: critical evaluation of their predictive power.
Amino acid sequence patterns suggested to characterize specific recurrent turn conformation in protein are tested as to their predictive power in a database containing 75 proteins of known structure. Many of these patterns are found to be associated with local structures that differ from the motifs originally used to derive them. It is therefore concluded that, while they could be useful for improving predictions made by other methods, their stand-alone predictive power is poor. The issue of deriving and validating consensus sequence patterns for use in protein structure prediction is raised.
Rooman
M J
MJ
Unité Conformation de Macromolécules Biologiques, Université Libre de Bruxelles, Belgium.
Wodak
S J
SJ
Thornton
J M
JM
D000595:Amino Acid Sequence; D003196:Computer Graphics; D003198:Computer Simulation; D007256:Information Systems; D008958:Models, Molecular; D011487:Protein Conformation; D013698:Templates, Genetic