The questionable physiologic and epidemiologic basis for a male climacteric syndrome: preliminary results from the Massachusetts Male Aging Study.
This paper examines the physiologic and epidemiologic evidence for a widely discussed syndrome termed either 'mid-life crisis', 'male menopause', 'male climacteric', or increasingly, 'andropause'. The paper is divided into 2 parts: (1) a review of evidence from physiologic studies conducted over the last decade that examine endocrine function in aging males; (2) a description of the salient features of an ongoing multidisciplinary epidemiologic study (the Massachusetts Male Aging Study) of a sample of approximately 1700 men aged 40-69 yr, randomly sampled from the general population. This study is markedly different in size and content from studies conducted to date. Preliminary findings suggest that age per se may be a relatively unimportant contributor to endocrine variability and that anthropometrics and life style phenomena may be at least as important.
McKinlay
J B
JB
New England Research Institute, Watertown, MA 02172.
Longcope
C
C
Gray
A
A
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000886:Anthropometry; D002979:Climacteric / Q000502:physiology*; D003430:Cross-Sectional Studies; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006801:Humans; D008297:Male; D008404:Massachusetts; D008875:Middle Aged; D011897:Random Allocation; D012107:Research Design; D013577:Syndrome
D012739:Gonadal Steroid Hormones