Antibody-forming cell assays of avian paramyxoviruses: immunization of chickens demonstrates two serotype groups.
Chickens were immunized with eight different serotypes of avian paramyxovirus (PMV). Ninety percent of splenic IgG antibody-forming cells (AFC) were serotype-specific with respect to the glycoprotein and nucleoprotein-polymerase antigens in an indirect immunoperoxidase binding system. The IgG AFCs which cross-reacted between serotypes divided the serotypes into two mutually exclusive super serogroups composed of PMV-1, -3, -4, -7 and -9, and PMV-2, -6 and -8. PMV-5 was not tested.
Russell
P H
PH
Department of Veterinary Pathology, Royal Veterinary College, University of London, U.K.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000921:Antibody-Producing Cells / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D002645:Chickens; D007181:Inclusion Bodies, Viral / Q000276:immunology; D009698:Nucleoproteins / Q000276:immunology; D010252:Paramyxoviridae / Q000145:classification / Q000276:immunology*; D012703:Serotyping; D014764:Viral Proteins / Q000276:immunology
D000914:Antibodies, Viral; D000954:Antigens, Surface; D000956:Antigens, Viral; D009698:Nucleoproteins; D014764:Viral Proteins