The mutagenic effect of caprolactam in the spot test with (T x HT) F1 mouse embryos.
The mouse spot test was used to investigate the in vivo mutagenicity of caprolactam. Among offspring treated with 500 mg/kg, the frequency of spots was increased over controls in 4 separate experiments, leading to the conclusion that caprolactam is mutagenic in the spot test.
Neuhäuser-Klaus
A
A
Institut für Säugetiergenetik, Gesellschaft für Strahlen- und Umweltforschung (GSF), Neuherberg F.R.G.
Lehmacher
W
W
D000818:Animals; D001381:Azepines / Q000633:toxicity*; D002209:Caprolactam / Q000633:toxicity*; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D011247:Pregnancy
D001381:Azepines; D009153:Mutagens; D002209:Caprolactam