Effects of vitamin D3 metabolites in ovariectomized rats.
The effects of two vitamin D3 metabolites, 24R,25-dihydroxyvitamin D3 and 1 alpha,25-dihydroxyvitamin D3, were investigated in ovariectomized rats. The amount of ash in the femur on a defatted dry weight basis was significantly greater in rats treated with 1 microgram/kg 24R,25-dihydroxyvitamin D3, or 0.01 or 0.1 microgram/kg 1 alpha,25-dihydroxyvitamin D3 than in the controls. The concentration of bone gla protein in serum and amounts in the femur were significantly greater in rats treated with 1 or 10 micrograms/kg 24R,25-dihydroxyvitamin D3, but not those given 1 alpha,25-dihydroxyvitamin D3 compared with the controls. These results suggest that 24R,25-dihydroxyvitamin D3 increased bone mass probably through the stimulation of bone formation.
Orimo
H
H
Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan.
Tsutsumi
C
C
Hosoya
N
N
Maeda
Y
Y
Yamato
H
H
Katoh
T
T
D015650:24,25-Dihydroxyvitamin D 3; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001806:Blood Urea Nitrogen; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002116:Calcitonin / Q000097:blood; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D002135:Calcium-Binding Proteins / Q000097:blood; D004100:Dihydroxycholecalciferols / Q000494:pharmacology*; D005260:Female; D005269:Femur; D015675:Osteocalcin; D010052:Ovariectomy; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
D002135:Calcium-Binding Proteins; D004100:Dihydroxycholecalciferols; D010281:Parathyroid Hormone; D010710:Phosphates; D015675:Osteocalcin; D015650:24,25-Dihydroxyvitamin D 3; D002116:Calcitonin; D000469:Alkaline Phosphatase; D002117:Calcitriol; D002118:Calcium