title: Prognostic significance of the DNA content of renal carcinoma.
abstract: DNA analysis was performed on fresh frozen samples of the primary tumor in 32 patients with renal carcinoma (13 with apparently localized disease and 19 with metastases at presentation). A comparison of ploidy with staging and standard histologic variables was performed. None of the patients who presented without metastases died of disease during the follow-up period. Eleven of 13 patients of this group had a diploid/near diploid pattern, and metastases developed in only one patient. Patients with metastatic disease and a diploid/near diploid DNA content had a significantly better survival rate than those with aneuploid primary tumors. Statistical analysis showed that grade and ploidy contributed significant but independent prognostic information. We concluded that DNA content is a useful prognostic factor in renal carcinoma.
authors: Department of Surgery, UCLA School of Medicine 90024.
authors: J B
authors: JB
authors: deKernion
authors: E
authors: E
authors: Mukamel
authors: A W
authors: AW
authors: Ritchie
authors: B
authors: B
authors: Blyth
authors: J
authors: J
authors: Hannah
authors: R
authors: R
authors: Bohman
mesh_terms: D000328:Adult; D000368:Aged; D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis
chemical_list: D004273:DNA, Neoplasm