Assignment of defensin gene(s) to human chromosome 8p23.
A relatively abundant component of the polymorphonuclear leukocyte granulocytes has been recently isolated and called defensin. Defensins have antimicrobial activity against gram-positive and gram-negative bacteria and enveloped viruses. A cDNA insert for defensin HNP-1 (DEF1) has been used to map the gene(s) to human chromosome 8p23 using a mouse/human somatic cell hybrid panel and in situ hybridization to normal human metaphase chromosomes. Because of the similarity of HNP-1 defensin to other defensins, it is likely that two of these genes map to this region.
Sparkes
R S
RS
Department of Medicine, UCLA Center for the Health Sciences 90024.
Kronenberg
M
M
Heinzmann
C
C
Daher
K A
KA
Klisak
I
I
Ganz
T
T
Mohandas
T
T
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8 / Q000648:ultrastructure*; D006801:Humans; D006822:Hybrid Cells; D066298:In Vitro Techniques; D051379:Mice; D009504:Neutrophils / Q000502:physiology; D011506:Proteins / Q000235:genetics*; D023084:alpha-Defensins
D011506:Proteins; D023084:alpha-Defensins; C406413:human neutrophil peptide 1