title: A conservative viewpoint on linkage in Alzheimer's disease.
abstract: Linkage data in Alzheimer's disease have not firmly established a genetic locus on chromosome 21 in early onset disease families. There is little or no support for a chromosome 21 locus in late onset families. Differences in the selection of families and the analysis of data accounts for the differences in interpretation. The actual location of a genetic locus (or loci) for Alzheimer's disease in the human genome will not be influenced by this controversy; more data from exclusion mapping and the use of several methods of linkage analysis will answer current questions.
authors: Division of Neurology, Duke University Medical Center, Durham, NC 27710.
authors: A D
authors: AD
authors: Roses
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21; D008040:Genetic Linkage; D006801:Humans