[Interferon responses of various populations of lymphocytes of inbred mice with various degrees of sensitivity to the western equine encephalitis virus].
The sensitivity of mice of three lines: CBA, BALB/C, and C57BL/6 (males aged greater than or equal to 4-5 and one week) to peripheral inoculation with Western equine encephalomyelitis (WEE) virus was studied. The C57BL/6 line was found to be the most and CBA the least sensitive. The first generation hybrids between these lines are intermediate in their sensitivity to WEE virus. A correlation was established between the increased sensitivity to WEE virus of C57BL/6 mice and the defect of the interferon system in these mice manifested by the extremely low capacity of their thymocytes for production of beta and alpha-interferons, as well as by a significant decrease of interferon responses of splenocytes to Newcastle disease virus, L-1 (alpha-interferon), lafarin, beta-interferon, concanaxalin-A (alpha-interferon) after immunization with antigens of different origin.
Tazulakhova
E B
EB
Nesterchuk
S L
SL
Mezentseva
M V
MV
Ershov
F I
FI
Barinskiĭ
I F
IF
D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D004198:Disease Susceptibility; D004667:Encephalitis Virus, Western Equine / Q000276:immunology; D004683:Encephalomyelitis, Equine / Q000276:immunology*; D007113:Immunity, Innate; D007370:Interferon Type I / Q000096:biosynthesis*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008810:Mice, Inbred C57BL / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D007370:Interferon Type I
Interferonovye reaktsii razlichnykh populiatsii limfotsitov inbrednykh liniĭ mysheĭ s raznoĭ stepen'iu chuvstvitel'nosti k virusu zapadnogo éntsefalomielita loshadeĭ.