[The effect of modification of excipients for the bioavailability of vinburnine].
Biopharmaceutic comparison is achieved between commercialized capsules of vinburnine and a new dosage form. The difference between the two drug products concerns only the quality of excipients. Drug bioavailability decreases of about 10%, in despite of the very important, and well known, interindividual variations of vincamine drug products. Only the absorption rate seems statistically lightly decreased by the new formulation.
Sado
P A
PA
Gibassier
D
D
Leverge
R
R
D000328:Adult; D001682:Biological Availability; D005079:Excipients; D005260:Female; D006801:Humans; D008297:Male; D014748:Vinca Alkaloids / Q000493:pharmacokinetics*
D005079:Excipients; D014748:Vinca Alkaloids; C016422:eburnamonine
Influence d'une modification d'excipients sur la biodisponibilité de la vinburnine.