title: Dietary supplementation of tyrosine prevents the rapid fall in blood pressure during haemorrhage.
abstract: Previous studies have demonstrated the ability of tyrosine (TYR), the amino acid precursor of catecholamines, to increase blood pressure in rats made hypotensive by haemorrhage. Other studies have shown that supplementation of the diet with TYR can reverse certain neurochemical and behavioural consequences associated with acute stress. Such studies demonstrate that during conditions of enhanced neuronal firing catecholamine synthesis is accelerated when additional precursor TYR is made available. In these situations the rate-limiting enzyme of catecholamine synthesis, tyrosine hydroxylase, activated via phosphorylation, becomes responsive to additional TYR. Our experiments were designed to study the ability of dietary TYR (3.7%, or 4X the normal amount), to prevent the rapid fall in blood pressure observed during acute haemorrhage. Rats consuming the high TYR diet (5 days) maintained arterial blood pressure (systolic, diastolic and mean) at significantly greater values during the period of acute haemorrhagic insult than animals maintained on a control diet. Rats fed the high TYR diet had significantly greater levels of the amino acid in the heart, adrenal glands, liver, kidney, brainstem, spleen and semimembranosus pars caudalis muscle. We conclude that TYR can be stored and most likely utilized in the synthesis of catecholamines for the maintenance of arterial blood pressure during acute haemorrhage. These results are of particular importance in light of the fact that most total parenteral nutrition solutions contain very little if any TYR.
authors: Department of Pharmacology, Massachusetts College of Pharmacy, Boston.
authors: F A
authors: FA
authors: Moya-Huff
authors: J M
authors: JM
authors: Pinto
authors: P J
authors: PJ
authors: Kiritsy
authors: T J
authors: TJ
authors: Maher
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002395:Catecholamines / Q000096:biosynthesis; D004032:Diet; D006470:Hemorrhage / Q000150:complications* / Q000503:physiopathology; D007022:Hypotension / Q000517:prevention & control*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000150:complications / Q000503:physiopathology; D014443:Tyrosine / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D002395:Catecholamines; D014443:Tyrosine