Low natural antibody and low in vivo tumor resistance, in xid-bearing B-cell deficient mice.
Evidence from correlative studies and Winn-type assays in syngeneic murine models has suggested that natural antibodies contribute to resistance against tumors in vivo. The B cell deficit associated with the X-linked immunodeficiency of CBA/N strain mice provided a genetic model in which to further test this question. RI-28, a radiation-induced T cell leukemia of the CBA/H strain acquired reduced levels of fluorescence-detected natural antibodies from the serum of X-linked immunodeficiency-bearing CBA/N and male (CBA/N x CBA/J) F1 mice compared with the serum from normals. Threshold s.c. inocula of the RI-28 appeared sooner and produced higher tumor frequencies in the X-linked immunodeficiency-bearing animals. This data coupled with the lack of correlating deficiencies in natural killer cell or activated macrophage activity provide the first genetic evidence for the hypothesis.
Chow
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DA
Department of Immunology, University of Manitoba, Winnipeg, Canada.
Bennet
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D000818:Animals; D000912:Antibodies, Neoplasm / Q000096:biosynthesis*; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D003165:Complement System Proteins / Q000502:physiology; D003433:Crosses, Genetic; D003602:Cytotoxicity, Immunologic; D005260:Female; D007113:Immunity, Innate; D007153:Immunologic Deficiency Syndromes / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D007694:Killer Cells, Natural / Q000276:immunology; D015458:Leukemia, T-Cell / Q000209:etiology / Q000276:immunology*; D008262:Macrophage Activation; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008817:Mice, Mutant Strains; D012727:Sex Characteristics; D014960:X Chromosome
D000912:Antibodies, Neoplasm; D003165:Complement System Proteins