[Effect of Polfos on the bleeding time. II. Changes in selected parameters of the blood coagulation system and fibrinolysis].
The influence of Polfos on some parameters of the coagulation system and fibrinolysis in rats was examined. The present results indicate that Polfos had no effect on the coagulation system and fibrinolysis in the initial phase of intoxication (2 hours). In the late phase of intoxication (24 hours) a decrease in the prothrombin index, shortening of thrombin time, increase in the fibrinogen level and prolongation of euglobulin lysis time were observed. The results demonstrate that the normalization of the bleeding time in the late phase of intoxication depended on activation of the coagulation system and inhibition of fibrinolysis activation.
Konopelko
M
M
Akademia Medyczna w Białymstoku, Zakład Farmakodynamiki.
Malinowska
B
B
Chabielska
E
E
Buczko
W
W
D000818:Animals; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D002709:Chlorfenvinphos / Q000031:analogs & derivatives / Q000506:poisoning*; D005342:Fibrinolysis / Q000187:drug effects; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007306:Insecticides; C006037:methylbromfenvinphos; D002709:Chlorfenvinphos
Wpływ Polfosu na czas krwawienia. II. Zachowanie sie wybranych parametrów układu krzepniecia i fibrynolizy.