[Plasmapheresis in the combined treatment of the kidney transplant rejection crisis].
A total of 15 recipients of renal allotransplant were subjected to 41 sessions of gravitation plasmapheresis after immunosuppressive treatment with sandimmun, methypred, and azathioprine performed for prevention of acute steroid-resistant rejections. The efficacy of plasmapheresis was proved in 6 patients with early and 4 patients with advanced stages of the rejection crises. The authors developed the criteria for the assessment of plasmapheresis efficacy which should be considered for defining the optimal treatment regimens: the time-course of diuresis, the number of leukocytes, the plasma levels of creatinine and circulating immune complexes, the blood levels of IgG, IgA, IgM and the number of active rosette-forming cells, the blood serum complement activity (measured at least 24 hrs after the session).
Serniak
P S
PS
Kovalenko
N V
NV
Bogomolov
A M
AM
Zakharov
V V
VV
Chernobrivtsev
P A
PA
D000208:Acute Disease; D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D003131:Combined Modality Therapy; D005260:Female; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016030:Kidney Transplantation / Q000276:immunology; D010956:Plasmapheresis / Q000379:methods; D011183:Postoperative Complications / Q000628:therapy*; D012397:Rosette Formation
D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D007166:Immunosuppressive Agents
Plazmaferez v kompleksnom lechenii kriza ottorzheniia pochechnogo transplantata.