title: Congenital cutis laxa.
abstract: We have encountered 2 cases (mother and son) with an autosomal dominant form of cutis laxa, which is clinically characterized by inelastic, loose, and pendulous skin without systemic organ involvement. The histopathological findings disclosed that the elastic fibers were decreased in number and had abnormalities in shape. Furthermore, electron microscopic observations showed some variations in structural abnormalities of the elastic fibers between the 2 cases. These findings may suggest that the elastic fibers seen in congenital cutis laxa give various features for elastogenesis and elastolysis in the individual cases, perhaps due to aging.
authors: Department of Dermatology, Shizuoka General Hospital, Japan.
authors: T
authors: T
authors: Oku
authors: F
authors: F
authors: Nakayama
authors: S
authors: S
authors: Imaizumi
authors: M
authors: M
authors: Takigawa
authors: M
authors: M
authors: Yamada
mesh_terms: D000328:Adult; D000375:Aging / Q000473:pathology; D003483:Cutis Laxa / Q000151:congenital* / Q000235:genetics / Q000473:pathology; D004547:Elastic Tissue / Q000648:ultrastructure; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D007223:Infant; D008297:Male