Two types of A-current differing in voltage-dependence are expressed by neurons of the rat neostriatum.
Transient potassium currents of the A type are thought to be important in a number of physiological processes of excitable cells, including spike repolarization and synaptic integration. This functional diversity may reflect the contribution of distinct subtypes of A channel to cellular behavior. Using the whole-cell variant of the patch clamp technique, we have found that two types of A-current are expressed in rat neostriatal neurons, one that is similar to previous descriptions in mammals and a second that is activated at considerably more depolarized potentials.
Surmeier
D J
DJ
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis 38163.
Bargas
J
J
Kitai
S T
ST
D000818:Animals; D003342:Corpus Striatum / Q000502:physiology*; D004553:Electric Conductivity; D008564:Membrane Potentials; D009474:Neurons / Q000502:physiology; D051381:Rats