title: Trial of a novel experimental Toxoplasma iscom vaccine in pregnant sheep.
abstract: Fifteen vaccinated ewes (group 1) and 13 unvaccinated ewes (group 2) were each challenged orally with 2000 sporulated Toxoplasma gondii oocysts at 91 (+/- 1) days' gestation. Another four pregnant ewes acted as unvaccinated unchallenged controls. Lamb mortality in group 1 was 36.4% after a mean gestation of 141 days while in group 2 it was 64.7% after a mean gestation of 131.5 days. These differences were not statistically significant. However, substantially more specific antibody was detected in precolostral sera from live lambs from vaccinated ewes than in live lambs from unvaccinated ewes in group 2.
authors: D
authors: D
authors: Buxton
authors: A
authors: A
authors: Uggla
authors: K
authors: K
authors: Lövgren
authors: K
authors: K
authors: Thomson
authors: A
authors: A
authors: Lundén
authors: B
authors: B
authors: Morein
authors: D A
authors: DA
authors: Blewett
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D005260:Female; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*; D014122:Toxoplasma / Q000276:immunology*; D014124:Toxoplasmosis, Animal / Q000151:congenital / Q000517:prevention & control*; D014611:Vaccination / Q000662:veterinary
chemical_list: D000276:Adjuvants, Immunologic