Anaphylactoid reaction to chymopapain.
Chymopapain is a proteolytic enzyme used in the chemonucleolysis of the herniated nucleus pulposus of lumbar intervertebral discs. It causes rapid hydrolysis of the noncollagenous polypeptides that maintain the tertiary structure of the chondromucoprotein of the nucleus pulposus. We report here an anaphylactoid reaction after the intervertebral injection of chymopapain.
Smith
M B
MB
Department of Anesthesiology, University of Oklahoma, Oklahoma City 73190.
Hofmann
V C
VC
D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced*; D002917:Chymopapain / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D013129:Spinal Puncture; D013997:Time Factors
D002917:Chymopapain