Ontogeny of high affinity uptake of GABA studied in 'minislices' (tissue prisms) of rat cerebral cortex.
There has been a considerable discrepancy between the values of Vmax of high affinity uptake of gamma-aminobutyric acid (GABA) obtained in slices and homogenates, respectively, of developing rat cortex. In the present communication, it is suggested that the relatively low values observed in slices of early postnatal cortex might be explained by damage to the immature tissue during the experiment. The possible locations of high affinity uptake of GABA in developing rat cortex are discussed.
Balcar
V J
VJ
Department of Anatomy, University of Sydney, N.S.W., Australia.
Johnston
G A
GA
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000254:growth & development / Q000378:metabolism*; D066298:In Vitro Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000493:pharmacokinetics*
D005680:gamma-Aminobutyric Acid