[Serial assessment of myocardial thallium perfusion and fatty acid utilization in spontaneously hypertensive rats: assessment by autoradiography and pin-hole imaging].
To evaluate the advantage of free fatty acid imaging on the detection of hypertrophied myocardium, we compared sequentially myocardial thallium and BMIPP (15-(p-iodophenyl)-3-(R,S)-methyl pentadecanoic acid) distribution in spontaneously hypertensive rat (SHR) using dual tracer autoradiography and in vivo pin-hole imaging. Autoradiography and pin-hole imaging showed uniform myocardial distribution of BMIPP and thallium within less than 27 weeks age SHR. In 40 weeks age SHR, thallium myocardial distribution showed uniform, however, BMIPP had focal decreases. Quantitative analysis of pin-hole images showed that myocardial BMIPP and thallium uptake ratio decreased according to the ages of SHR. Our data suggest that hypertension is associated with uniform myocardial perfusion and focal alternation in the substrate used for the performance of myocardial work. Based on the above autoradiographic and in vivo pin-hole imagings, I-123 BMIPP imaging may have a potential for early detection on hypertrophic myocardium compared to thallium perfusion in clinically hypertensive patients.
Sago
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M
Nishimura
T
T
D000818:Animals; D001345:Autoradiography; D005227:Fatty Acids; D006973:Hypertension / Q000378:metabolism*; D007462:Iodobenzenes / Q000493:pharmacokinetics*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D013793:Thallium / Q000493:pharmacokinetics*
D005227:Fatty Acids; D007462:Iodobenzenes; C049338:iodofiltic acid; D013793:Thallium