Brain neocortex modulation of mitogen-induced interleukin 2, but not interleukin 1, production.
Interleukin 2 (IL-2) production by splenic T cells stimulated by Concanavalin A was studied in mice after unilateral or bilateral brain neocortex ablation. The brain cortex was shown to modulate IL-2 production in an asymmetrical way. IL-2 levels were higher in animals with a right cortical lesion (group R) and lower in mice with a symmetrical lesion (group L) as compared to controls, differences between groups R and L being significant. Such variations of IL-2 production that were observed after unilateral lesions were abolished with bilateral cortical ablations. These results extend the immunoregulatory roles of the brain neocortex to IL-2 production by splenic T cells and may provide molecular support for neuro-immunological networks.
Neveu
P J
PJ
INSERM U. 259, Université de Bordeaux II, Domaine de Carreire, France.
Barnéoud
P
P
Vitiello
S
S
Kelley
K W
KW
Le Moal
M A
MA
D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000502:physiology*; D003208:Concanavalin A / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007375:Interleukin-1 / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D051379:Mice; D008809:Mice, Inbred C3H; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000378:metabolism*
D007375:Interleukin-1; D007376:Interleukin-2; D003208:Concanavalin A