[Secondary messenger level of inositol triphosphate in fibroblasts after treatment with papaverine].
Ten per cent foetal bovine serum had been added to human embryonic fibroblasts which had previously been incubated in serum free cultures. The effect has been studied on quantity of synthetized DNA in next 30 hours and on inositol-1,4,5-phosphate contents of cells. On the effect of foetal bovine serum synthesis of DNA has increased four times and 1 minute after its addition inositol-1,4,5-phosphate level has doubled. Papaverine given together with FBS has suspended inductive effect of FBS on DNA synthesis and its increasing effect on level of inositol-1,4,5-phosphate.
Vályi-Nagy
T
T
Bándi
Z
Z
Boldogh
I
I
Albrecht
T
T
D002478:Cells, Cultured; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate; D007295:Inositol Phosphates / Q000502:physiology*; D010208:Papaverine / Q000494:pharmacology*; D015290:Second Messenger Systems / Q000187:drug effects*; D013403:Sugar Phosphates / Q000502:physiology*
D007295:Inositol Phosphates; D013403:Sugar Phosphates; D015544:Inositol 1,4,5-Trisphosphate; D010208:Papaverine
Az inozitol-trifoszfát másodlagos messenger szintje fibroblasztokban papaverin kezelés után.