Identification of plasma proteins contained in bronchoalveolar fluid from Macacus cynomolgus.
1. Serial bronchoalveolar lavages (BAL) were performed on a subhuman primate (Macacus cynomolgus) in order to give an experimental model for silicosis. 2. We have identified and quantified some plasma proteins of monkey BAL fluid. 3. The results were compared to those previously obtained in humans. 4. Two proteins previously detected in human BAL fluid (alpha 1 acid glycoprotein, alpha 1 antichymotrypsin) were not detected in monkey control BAL fluid. 5. Two kinds of transferrins were detected in monkey BAL fluids while only one is described in human. 6. The present results will now permit sequential follow up studies during the course of experimental silicosis.
Hannothiaux
M H
MH
Unité des Protéines INSERM No. 16, Lille, France.
Scharfman
A
A
Leger
D
D
Van Brussel
E
E
Lafitte
J J
JJ
Roussel
P
P
D000818:Animals; D001798:Blood Proteins / Q000032:analysis*; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis*; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D008251:Macaca / Q000378:metabolism*; D008252:Macaca fascicularis / Q000378:metabolism*; D011480:Protease Inhibitors / Q000032:analysis; D012709:Serum Albumin / Q000032:analysis; D014168:Transferrin / Q000032:analysis / Q000302:isolation & purification; D000515:alpha 1-Antitrypsin
D001798:Blood Proteins; D011480:Protease Inhibitors; D012709:Serum Albumin; D014168:Transferrin; D000515:alpha 1-Antitrypsin