The development of an animal model of glioma for use in experimental neuro-oncology.
A cell line, 497-P(1), derived from the VM spontaneous murine astrocytoma has been used to develop an in vitro in vivo model of human glioma. This paper describes the growth characteristics of tumours produced after intracerebral or subcutaneous inoculation of 497-P(1) cells into syngeneic VM mice. The results show that cell line 497-P(1) provides the basis for a reproducible animal model of glioma which fulfils many of the criteria required for experimental therapy studies.
Bradford
R
R
Gough-Cooper Department of Neurological Surgery, Institute of Neurology, London, United Kingdom.
Darling
J L
JL
Thomas
D G
DG
D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D002460:Cell Line; D004195:Disease Models, Animal; D005910:Glioma / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured