Evidence of 11 beta-hydroxylase deficiency in a patient with cortical adrenal adenoma.
We explored a 61 year old woman with mild hirsutism. An adrenal tumor was found in the left adrenal, which was held responsible for the androgen secretion. The in vitro incubation of the tumor tissue showed an impaired 11 beta-hydroxylation of 11-deoxycortisol. This is a rare and unusual case of adrenal pathology showing that a deficiency in 11 beta-hydroxylase activity does not rule out the presence of an adrenocortical adenoma.
Touitou
Y
Y
Faculté de Médecine Pitié-Salpêtrière, Service de Biochimie Médicale, Paris, France.
Lecomte
P
P
Auzéby
A
A
Bogdan
A
A
Besnier
Y
Y
D000236:Adenoma / Q000201:enzymology* / Q000601:surgery; D000306:Adrenal Cortex Neoplasms / Q000201:enzymology* / Q000601:surgery; D000312:Adrenal Hyperplasia, Congenital; D000315:Adrenalectomy; D000728:Androgens / Q000097:blood; D005260:Female; D006801:Humans; D007664:Ketosteroids / Q000096:biosynthesis; D008875:Middle Aged; D013250:Steroid Hydroxylases / Q000172:deficiency*
D000728:Androgens; D007664:Ketosteroids; D013250:Steroid Hydroxylases