[In vivo bactericidal effect of ciprofloxacin, ofloxacin and pefloxacin against Staphylococcus aureus].
The bactericidal activity of ciprofloxacin, ofloxacin, pefloxacin, against methicillin sensitive S. aureus (2 different strains) was studied on a model of infected fibrin clots inserted subcutaneously in rabbit. The quinolones were delivered intravenously, as a single daily dose of 100 mg/kg/day. The bactericidal activity was evaluated by determining for various time points (1 h, 2 h, 6 h, 12 h, and 24 h after the infusion of the antibiotics), viable organisms in the dissolved clots. This study shows that: 1) No significant difference appears between the quinolones studied. 2) The in vivo early bactericidal activity of quinolones against S. aureus appears to be better than oxacillin but lesser than oxacillin-netilmicin combination.
Tronel
H
H
Service des Maladies Infectieuses, Centre Hospitalier Universitaire Nancy-Brabois, Vandoeuvre-Lès-Nancy.
Voiriot
P
P
Weber
M
M
Dopff
C
C
Dewachter
P
P
Phelisse
F
F
Dureux
J B
JB
D000818:Animals; D002939:Ciprofloxacin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology*; D015366:Pefloxacin / Q000494:pharmacology*; D011817:Rabbits; D013203:Staphylococcal Infections; D013211:Staphylococcus aureus / Q000187:drug effects*
D015366:Pefloxacin; D002939:Ciprofloxacin; D015242:Ofloxacin
Etude de l'activité bactéricide in vivo de la ciprofloxacine, de l'ofloxacine et de la péfloxacine vis-à-vis de Staphylococcus aureus.