Novel antitumor antibiotic phospholine. 2. Structure determination.
Phospholine, an antitumor antibiotic, has the molecular formula of C25H40NO8P and possesses a delta-lactone and a phosphoric acid ester as functional groups. Its structure was determined based on interpretation of fast atom bombardment MS, 1H NMR, 13C NMR, 1H-1H correlation spectroscopy (COSY), 13C-1H COSY, heteronuclear multiple bond correlation spectroscopy, elemental analysis and chemical modifications.
Ozasa
T
T
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
Tanaka
K
K
Sasamata
M
M
Kaniwa
H
H
Shimizu
M
M
Matsumoto
H
H
Iwanami
M
M
D000903:Antibiotics, Antineoplastic / Q000032:analysis* / Q000302:isolation & purification; D055598:Chemical Phenomena; D002621:Chemistry; D007783:Lactones / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D009943:Organophosphorus Compounds / Q000302:isolation & purification
D000903:Antibiotics, Antineoplastic; D007783:Lactones; D009943:Organophosphorus Compounds; C061212:phospholine