title: Total respiratory compliance during anaesthesia in infants and young children.
abstract: The multiple occlusion technique was used to study the effects of paralysis on ventilatory mechanics during anaesthesia. Total respiratory compliance (Crs) was measured during spontaneous breathing and following neuromuscular block with controlled ventilation in 23 infants. There was marked variation in response to paralysis: some infants demonstrated no change in Crs between the two states; others had values of Crs which were significantly higher during paralysis with controlled ventilation than during spontaneous breathing. A possible cause of these differences may be the type of controlled ventilation given during paralysis, with tidal volume directly influencing values of Crs obtained. The results of this study suggest that values of Crs obtained during spontaneous breathing and paralysis should not be used interchangeably until further studies have been performed to assess factors influencing Crs during controlled ventilation.
authors: Hospital for Sick Children, London.
authors: M E
authors: ME
authors: Fletcher
authors: J
authors: J
authors: Stocks
authors: S
authors: S
authors: Ridley
authors: N
authors: N
authors: Braude
authors: A P
authors: AP
authors: Yates
authors: D J
authors: DJ
authors: Hatch
mesh_terms: D000768:Anesthesia, General; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008170:Lung Compliance; D009466:Neuromuscular Blocking Agents; D011312:Pressure; D012119:Respiration; D012121:Respiration, Artificial; D012143:Respiratory Physiological Phenomena; D013990:Tidal Volume
chemical_list: D009466:Neuromuscular Blocking Agents