title: The Budd-Chiari syndrome caused by a zygomycete. A new pathogenesis of hepatic vein thrombosis.
abstract: The clinical history of a 60-year-old woman suffering from chronic lymphocytic leukemia with sudden deterioration and death is reported. The postmortem macroscopic and microscopic findings included pulmonary aspergillosis and pulmonary zygomycosis (mucormycosis). Hematogenous dissemination of the zygomycete causing cardiac zygomycosis, cerebral infarcts due to vascular occlusion by hyphae, and thrombosis of the major hepatic veins (Budd-Chiari syndrome) with submassive necrosis of the right liver lobe were also observed. To our knowledge, this is the second report dealing with occlusion of the hepatic veins caused by a fungus and the first study reporting the Budd-Chiari syndrome due to a mold of the subclass Zygomycetes.
authors: N. Goormaghtigh Institute of Pathology, State University of Ghent, Belgium.
authors: J H
authors: JH
authors: Vallaeys
authors: M M
authors: MM
authors: Praet
authors: H J
authors: HJ
authors: Roels
authors: E
authors: E
authors: Van Marck
authors: L
authors: L
authors: Kaufman
mesh_terms: D006502:Budd-Chiari Syndrome / Q000209:etiology* / Q000473:pathology; D005260:Female; D006503:Hepatic Veins / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications; D008875:Middle Aged; D009091:Mucormycosis / Q000150:complications* / Q000473:pathology