[Immunologic findings in the newborn infant. II. Studies of humoral immunity, reference values of immunologic studies in the newborn infant].
After dealing with cellular immune aspects in the first part of the paper the authors describe in the second part the state of humoral immunity in healthy full-term newborns aged one to three days. The number of complementreceptor lymphocytes was 17.0 +/- 8.9% or 0.75 +/- 0.51 (mean +/- S.D.) respectively, with the EAC-rosette method. The percentage value equalled that of adults but the absolute count is higher. Using the immunodiffusion method IgA was detectable in 4 out of 132 newborns only 8.86 +/- 2.52 g/l (mean +/- S.D.) was measured as an average IgG concentration. With regard to the IgM content the values often exceeded 0.30 g/l in newborns of mothers who had been suffering from pre-eclampsia. Their mean value of 0.35 +/- 0.21 g/l, too, was significantly higher than 0.13 +/- 0.08 in the resting infants. Raised IgM values frequently coincided with high spontaneous transformation activities in lymphocyte cultures. The possible causes are discussed. Complement C3-component was measured on average with 0.78 +/- 0.18 g/l and C4-component with 0.34 +/- 0.11 g/l. When calculating reference values for newborns the results of infants with maternal pre-eclampsia have been omitted.
Weinmann
G
G
Menzel
K
K
D003176:Complement C3 / Q000032:analysis*; D003181:Complement C4 / Q000032:analysis*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D007231:Infant, Newborn / Q000276:immunology*; D008297:Male; D011225:Pre-Eclampsia / Q000276:immunology; D011247:Pregnancy; D011951:Receptors, Complement / Q000032:analysis*; D012016:Reference Values; D012397:Rosette Formation
D003176:Complement C3; D003181:Complement C4; D007136:Immunoglobulins; D011951:Receptors, Complement
Immunologïsche Befunde des Neugeborenen. II. Untersuchungen zur humoralen Immunität, Referenzwerte immunologischer Untersuchungen beim Neugeborenen.