Retardation of growth and epithelial differentiation in suckling mice by anti-EGF antisera.
Anti-EGF serum administered to newborn mice led to an increasing rate of growth retardation and body weight gain during the following period up to 5 weeks after birth, but sometimes to an effect found reversible after 3-4 weeks. In addition, striking delay of differentiation of skin epidermis and appendages and of intestinal Paneth's cells was ascertained about 4 weeks after birth. The findings point to neutralization of EGF or abolition of its effects by anti-EGF serum and, thus, substantiate the suggestion that EGF plays a physiological role during the early postnatal growth and differentiation.
Zschiesche
W
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Central Institute of Molecular Biology of the Academy of Sciences of the GDR, Berlin.
D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000276:immunology / Q000494:pharmacology / Q000502:physiology*; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D006128:Growth / Q000187:drug effects; D007106:Immune Sera / Q000008:administration & dosage*; D051379:Mice; D008815:Mice, Inbred Strains; D012016:Reference Values
D007106:Immune Sera; D004815:Epidermal Growth Factor