title: Effects of ammonia on the gastric mucosal barrier in rats and dogs.
abstract: We examined the effect of ammonia on the gastric mucosal barrier by measuring the changes in transmucosal fluxes of H+, Na+ and K+. In rats, ammonia at concentrations of 0.1 to 0.5% increased the H+ loss from the lumen and 0.2 to 0.5% concentrations of ammonia increased both Na+ and K+ influxes into the lumen. In dogs, in an exactly similar manner to rats, ammonia at concentrations of 0.1 to 0.5% increased H+ loss, and ammonia at concentration of 0.5% increased both Na+ and K+ influxes into the lumen. These results suggest that ammonia breaks the gastric mucosal barrier.
authors: Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Japan.
authors: M
authors: M
authors: Seiki
authors: M
authors: M
authors: Murakami
authors: J K
authors: JK
authors: Yoo
authors: S
authors: S
authors: Teranuma
authors: H
authors: H
authors: Saita
authors: M
authors: M
authors: Inada
authors: T
authors: T
authors: Kita
authors: T
authors: T
authors: Miyake
mesh_terms: D000641:Ammonia / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006859:Hydrogen / Q000378:metabolism; D008297:Male; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism; D013045:Species Specificity
chemical_list: D000641:Ammonia; D006859:Hydrogen; D012964:Sodium; D011188:Potassium