Comparative study on cytogenetic effects by diplatinum complexes of the ligands of naphthazarine and squaric acid in human lymphocytes.
The effect of diplatinum complexes of the binucleating ligands of naphthazarine and squaric acid on Sister Chromatid Exchange (SCE) rates and human lymphocyte proliferation kinetics was studied. Squarodicisplatinum complex I, naphthazarindicisplatinum and squarodicisplatinum complex II induce cytotoxic effects as can be deduced from the resulted induction of SCEs and the produced cell division delays. Squarodicisplatinum complex I was found to be on a molar basis the most effective in causing markedly increased SCE rates and cell division delays. Cis-diaminodichloride platinum was found to be next in order of effectiveness with naphthazarindicisplatinum and squarodicisplatinum complex II following. Naphthazarine and SQA were found to be ineffective on induction of SCEs.
Lialiaris
T
T
Department of Medicinal Biology and Genetics, Faculty of Medicine, Aristotelian University, Thessaloniki, Greece.
Mourelatos
D
D
Boutis
L
L
Papageorgiou
A
A
Christianopoulou
M
M
Papageorgiou
V
V
Dozi-Vassiliades
J
J
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D003503:Cyclobutanes / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D009285:Naphthoquinones / Q000494:pharmacology*; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000970:Antineoplastic Agents; D003503:Cyclobutanes; D009285:Naphthoquinones; D009944:Organoplatinum Compounds; C005503:naphthazarin; D002945:Cisplatin; C030042:squaric acid