Possible recombinogenic effect of caprolactam in the mammalian spot test.
Tests of caprolactam in the mouse spot test showed that treatment with this compound increased the frequency of color spots among animals treated in utero. The nature of these spots suggests that caprolactam may induce spots through the induction of mitotic recombination.
Fahrig
R
R
Fraunhofer-Institut für Toxikologie und Aerosolforschung, Abteilung Genetik, F.R.G.
D000818:Animals; D001381:Azepines / Q000633:toxicity*; D002209:Caprolactam / Q000633:toxicity*; D002874:Chromosome Mapping; D004622:Embryo, Mammalian / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D011995:Recombination, Genetic / Q000187:drug effects*
D001381:Azepines; D009153:Mutagens; D002209:Caprolactam