title: Functional brain asymmetry and murine systemic lupus erythematosus.
abstract: The role of brain lateralization in antibody production was studied in a murine systemic lupus erythematosus model. Male and female New Zealand black mice that spontaneously produce pathogenic auto-antibodies directed against red blood cells and DNA, were divided into right- and left-handers using a paw preference test, and anti-erythrocyte and anti-DNA antibody production was repeatedly determined. In females, antibodies against erythrocytes and double-stranded DNA appeared earlier in left-handers. These results provide the first evidence of an association between a functional brain asymmetry and auto-antibody production and suggest the involvement of the central nervous system in the pathogenesis of autoimmune processes.
authors: INSERM U. 259, Laboratorie de Psychobiologie des Comportements Adaptatifs, Université de Bordeaux II, France.
authors: P J
authors: PJ
authors: Neveu
authors: C
authors: C
authors: Betancur
authors: P
authors: P
authors: Barnéoud
authors: J L
authors: JL
authors: Preud'Homme
authors: P
authors: P
authors: Aucouturier
authors: M
authors: M
authors: LeMoal
authors: S
authors: S
authors: Vitiello
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001921:Brain / Q000276:immunology* / Q000503:physiopathology; D004247:DNA / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000503:physiopathology*; D008297:Male; D051379:Mice
chemical_list: D001323:Autoantibodies; D004247:DNA