[Effects of diethylcarbamazine and ivermectin on the mobilization of microfilariae of Onchocerca volvulus].
Microfilaria of Onchocerca volvulus are localized in superficial dermis. However, they are sometimes noticed in the blood and urines, when there is an important infestation. Diethylcarbamazine (DEC) bring on an increase of microfilaria, successively in the blood and after, in the urines. This study of 30 patients, treated in double blind by placebo, DEC and ivermectin, a new molecule with spectacular action on this filariasis, allowed to compare effect of each one on apparition of microfilariae in the blood and urines. Ivermectin bring on very important increase of microfilaremia without microfilaruria, unlike diethylcarbamazine. This establishment bring to discuss very different physiologic mechanisms between them. It should have an incidence on diagnosis and treatment of this dangerous parasite.
Basset
D
D
Laboratoire de Microbiologie, Hôtel Dieu de Paris.
Bouree
P
P
Basset
A
A
Lariviere
M
M
D000328:Adult; D000818:Animals; D004049:Diethylcarbamazine / Q000627:therapeutic use*; D004311:Double-Blind Method; D005370:Filarioidea; D006801:Humans; D007559:Ivermectin / Q000627:therapeutic use*; D008302:Mali; D008842:Microfilariae / Q000187:drug effects*; D009855:Onchocerciasis / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D010919:Placebos
D010919:Placebos; D007559:Ivermectin; D004049:Diethylcarbamazine
Effets de la diéthylcarbamazine et de l'ivermectine sur la mobilisation des microfilaires d'Onchocerca volvulus.