Hypothalamo-pituitary-adrenal manipulations and stress ulcerations in rats.
Both gastric ulceration and activation of the hypothalamo-pituitary adrenal axis are considered integral to the stress response, and a causal relationship between the two has been suggested. In the present study, corticosterone secretion in rats was either stimulated with CRF or lowered with metyrapone during a known ulcerogenic stress. Reduction of circulating corticosterone during the stress had no effect on ulceration severity compared to saline-treated stressed control rats. Treatment with CRF in stressed animals reduced ulceration severity. The mechanism of this protective effect remains unclear. The findings do not support a simple causal relationship between adrenocortical activity and gastric ulceration.
Murison
R
R
Department of Physiological Psychology, University of Bergen, Norway.
Overmier
J B
JB
Hellhammer
D H
DH
Carmona
M
M
D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008797:Metyrapone / Q000494:pharmacology*; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D013312:Stress, Physiological / Q000097:blood / Q000150:complications* / Q000503:physiopathology
D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone; D008797:Metyrapone