[Salicylic acid and urea--possible modification of the keratolytic effect of salicylic acid by urea].
The keratolytic effect of salicylic acid was measured with a colorimeter after staining the outer layers of the stratum corneum with silver nitrate. Salicylic acid was used in a concentration of 5% or 10% in vaseline or of 5% in an improved vehicle. The results of two experiments showed that improvement of the vehicle increased the keratolytic effect of salicylic acid and that urea played a major role in this improvement.
Gabard
B
B
Spirig AG, Egerkingen.
Bieli
E
E
D003879:Dermatologic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D007641:Keratolytic Agents / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects*; D012880:Skin Pigmentation / Q000187:drug effects; D014508:Urea / Q000494:pharmacology*
D003879:Dermatologic Agents; D007641:Keratolytic Agents; D014508:Urea
Salizylsäure und Harnstoff--mögliche Beeinflussung der keratolytischen Wirkung von Salizylsäure durch Harnstoff.