[Effect of doprostone on fatty acid metabolism disturbances in the rat heart caused by adrenergic influences].
Administration of isoproterenol results in a marked increase (by 4.85 times) of the blood serum concentration of free fatty acids. In the heart there was found a four-fold increase of the concentration of long-chain acylcarnitine against the background of a reduction of free carnitine content. A preliminary administration of doprostone in a dose of 50 micrograms/kg intraperitoneally for 10 days completely prevents isoproterenol-induced increase of the serum concentration of free fatty acids and the heart concentration of long-chain acylcarnitine. Doprostone contributes also to preservation of the myocardium content of free carnitine under conditions of adrenergic influences. Correction of fatty acid metabolism under the influence of doprostone indicates the possibility of the heart protection against lesions caused by fatty acids and their detergent metabolites (long-chain acyl-CoA and acylcarnitine) during adrenergic and ischemic influences.
Simkhovich
B Z
BZ
Meĭrena
D V
DV
Khagi
Kh B
KhB
Freĭmanis
Ia F
IaF
D000108:Acetylcarnitine / Q000378:metabolism; D000527:Alprostadil / Q000494:pharmacology / Q000031:analogs & derivatives; D000818:Animals; D002331:Carnitine / Q000378:metabolism; D002395:Catecholamines / Q000502:physiology; D005227:Fatty Acids / Q000378:metabolism*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats
D002395:Catecholamines; D005227:Fatty Acids; D000108:Acetylcarnitine; D000527:Alprostadil; D007545:Isoproterenol; D002331:Carnitine; C034008:11-deoxyprostaglandin E1
Vliianie doprostona na vyzyvaemye adrenergicheskimi vozdeĭstviiami narusheniia metabolizma zhirnykh kislot v serdtse krys.