Fine needle aspiration cytology and immunocytochemistry of large cell lymphomas expressing the Ki-1 antigen.
Cytomorphology and immunocytochemistry were used to diagnose two cases of large cell anaplastic lymphomas that expressed the Ki-1 antigen. Smears stained with the May-Grünwald-Giemsa stain showed a cytomorphologic spectrum that varied from immunoblastlike cells to large tumor cells with pleomorphic nuclei. The tumor cells had a distinct basophilic cytoplasm, which often contained vacuoles. Giant cells with wreathlike multilobulated bizarre nuclei were also observed. Immunocytochemistry on a cytocentrifuged specimen showed that the tumor cells were of a T-helper phenotype; all strongly expressed the Ki-1 antigen and receptors for HLA-DR and IL-2.
Tani
E
E
Department of Pathology, Karolinska Hospital, Stockholm, Sweden.
Löwhagen
T
T
Nasiell
K
K
Ost
A
A
Skoog
L
L
D000293:Adolescent; D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis*; D001707:Biopsy, Needle; D005260:Female; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007376:Interleukin-2 / Q000378:metabolism; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008297:Male
D000951:Antigens, Neoplasm; D006684:HLA-DR Antigens; D007376:Interleukin-2