title: Effects of thyroxine on the development of self-grooming behavior in rats.
abstract: The effects of intraperitoneal thyroxine administration (1 microgram/body weight) on postnatal days 1-3 and the subsequent alterations upon the development of six self-grooming components were measured postnatally in male Wistar rats between days 1-60. Observations on self-grooming components showed that thyroxine-treated rats did not show consistent significant differences in the duration of grooming movements of short displacement directed to the forepaws and head throughout the study, as compared to controls. By contrast, after weaning, the duration of grooming movements of long displacement directed to the fur, genital area, and body scratching were significantly increased. The findings suggest that early thyroxine treatment may primarily interfere with the neural circuitry that modulate long displacement grooming movements, rather than with the substrates controlling short displacement grooming activities. Thus, the hormone might be acting upon neural modulatory systems of self-grooming having different vulnerability in relation to the level of maturity of the brain circuits underlying each grooming component.
authors: M
authors: M
authors: Salas
authors: S
authors: S
authors: Pulido
authors: C
authors: C
authors: Torrero
authors: C
authors: C
authors: Escobar
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D006120:Grooming / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D013974:Thyroxine