Pharmacokinetics of miocamycin in patients with liver cirrhosis.
The pharmacokinetics of miocamycin, a new macrolide antibiotic, was studied in 6 healthy controls and 6 patients with compensated liver cirrhosis. The results indicate that in chronic liver disease the kinetics of the drug is altered. Therefore, a dosage adjustment of miocamycin is recommended when dealing with these patients.
Miglioli
P A
PA
Department of Pharmacology, University of Padua, Italy.
Pivetta
P
P
Orlando
R
R
Palatini
P
P
Varotto
A
A
Okolicsanyi
L
L
D000284:Administration, Oral; D006207:Half-Life; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism*; D015644:Miocamycin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D015644:Miocamycin