[Myelopeptide correction of the differentiation of hematopoietic precursor cells in mice with experimental T-immunodeficiency].
The influence of myelopeptides on differentiation of bone marrow haemopoietic precursors cells in thymectomized and normal mice has been studied in vivo. The introduction of myelopeptides decreased the number of erythroid (E) colonies and increased that of granulocytic ones (G). This results in the decrease of initially raised E/G ratio in thymectomized mice (from 4.3) down to 1.3). Myelopeptides exerted no influence on haemopoietic precursors in normal mice (E/G-2.0).
Rudneva
T B
TB
Osipova
E Iu
EIu
Makhaĭlova
A A
AA
Man'ko
V M
VM
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation / Q000276:immunology; D002454:Cell Differentiation / Q000187:drug effects / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D004353:Drug Evaluation, Preclinical; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009842:Oligopeptides; D010455:Peptides / Q000494:pharmacology* / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology*; D013934:Thymectomy
D009842:Oligopeptides; D010455:Peptides; C048617:myelopeptides
Korrektsiia mielopeptidami differentsirovki krovetvornykh kletok-predshestvennikov u mysheĭ s éksperimental'nym T-immunodefitsitom.