[Evaluation of the capability of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and pyridine derivatives to evoke parkinsonism].
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produce an irreversible parkinsonian-like syndrome in humans, monkeys and mice C57BL/6. Experimental parkinsonism produced by MPTP on mice C57BL/6 were studied with the aim of working up the method for testing MPTP-like substances. It has been shown that intraperitoneal administration the maximal tolerated doses of MPTP cause significant decrease (by 40-60%) of dopamine content on the mice brain. Number of injections did not influence the results. The similar administration of 4-phenyl-pyridyl and 4,4'-dipyridyl derivates, including known herbicides paraquat and cyperquat, produce neither decrease of dopamine content in the brain, nor the development of parkinsonian-like behavioral syndrome.
Lermontiva
N N
NN
Soliakov
L S
LS
Bachurin
S O
SO
Tkachenko
S E
SE
Serkova
T P
TP
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D006540:Herbicides / Q000633:toxicity*; D020267:MPTP Poisoning; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009638:Norepinephrine / Q000032:analysis; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000378:metabolism; D011726:Pyridinium Compounds / Q000633:toxicity*; D012701:Serotonin / Q000032:analysis; D013329:Structure-Activity Relationship; D013997:Time Factors
D006540:Herbicides; D011726:Pyridinium Compounds; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine
Otsenka sposobnosti 1-metil-4-fenil-1,2,3,6-tetragidropiridina i nekotorykh proizvodnykh piridina vyzyvat' parkinsonizm.