title: Risk factors for gliomas and meningiomas in males in Los Angeles County.
abstract: Detailed job histories and information about other suspected risk factors were obtained during interviews with 272 men aged 25-69 with a primary brain tumor first diagnosed during 1980-1984 and with 272 individually matched neighbor controls. Separate analyses were conducted for the 202 glioma pairs and the 70 meningioma pairs. Meningioma, but not glioma, was related to having a serious head injury 20 or more years before diagnosis [odds ratio (OR) = 2.3; 95% confidence interval (CI) = 1.1-5.4], and a clear dose-response effect was observed relating meningioma risk to number of serious head injuries (P for trend = 0.01; OR for greater than or equal to 3 injuries = 6.2; CI = 1.2-31.7). Frequency of full-mouth dental X-ray examinations after age 25 related to both glioma (P for trend = 0.04) and meningioma risk (P for trend = 0.06). Glioma, but not meningioma risk, related to duration of prior employment in jobs likely to involve high exposure to electric and magnetic fields (P for trend = 0.05). This risk was greatest for astrocytoma (OR for employment in such jobs for greater than 5 years = 4.3; CI = 1.2-15.6). More glioma cases had worked in the rubber industry (discordant pairs 6/1) and more worked in hot processes using plastics (9/1). More meningioma cases had jobs that involved exposure to metal dusts and fumes (discordant pairs 13/5), and six of these cases and two controls worked as machinists. Finally, there was a protective effect among glioma pairs relating to frequency of use of vitamin C and other vitamin supplements (P for trend = 0.004); the OR for use at least twice a day was 0.4 (CI = 0.2-0.8).
authors: Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90033.
authors: S
authors: S
authors: Preston-Martin
authors: W
authors: W
authors: Mack
authors: B E
authors: BE
authors: Henderson
mesh_terms: D000428:Alcohol Drinking; D001932:Brain Neoplasms / Q000145:classification / Q000453:epidemiology / Q000209:etiology*; D002140:California; D016022:Case-Control Studies; D004781:Environmental Exposure; D005910:Glioma / Q000145:classification / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000145:classification / Q000453:epidemiology / Q000209:etiology*; D008579:Meningioma / Q000145:classification / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D009790:Occupations; D012307:Risk Factors; D012907:Smoking; D014965:X-Rays