[Effect of the cerebrospinal fluid from patients with cerebral pathology on regional cerebral blood flow in experimental animals].
In 15 chronically instrumented rabbits the local cerebral blood flow was measured in frontal, parietal and temporal cerebral cortex while high-molecular weight (protein) and low-molecular weight (peptide) fractions of cerebrospinal fluid (CSF) of epileptic and subarachnoidal hemorrhage patients was infused into their lateral brain ventricles. High molecular-weight fraction elicited pronounced and long-lasting vasoactive effects. This fraction taken from epileptic patients increased and from subarachnoidal hemorrhage patients decreased the local cerebral blood flow. The low-molecular weight fraction caused brief local cerebral flow changes in rabbits: an increase when taken from epileptic patients and decrease with epileptic patients' fraction.
Maĭorova
N F
NF
Aleksandrova
N P
NP
Alekseeva
L A
LA
D000818:Animals; D002540:Cerebral Cortex / Q000098:blood supply*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D002560:Cerebrovascular Circulation; D004827:Epilepsy / Q000134:cerebrospinal fluid*; D006801:Humans; D008970:Molecular Weight; D011817:Rabbits; D012039:Regional Blood Flow; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid*
Vliianie fraktsii spinnomozgovoĭ zhidkosti bo'lnykh s tserebra'lnoĭ patologieĭ na loka'lnyĭ mozgovoĭ krovotok u éksperimenta'lnykh zhivotnykh.