title: Hepatic arterial chemotherapy: role of angiography.
abstract: Hepatic arterial infusion chemotherapy increases the hepatic concentration of chemotherapeutic agents without increasing systemic toxicity. Both percutaneous (most commonly left transbrachial) and surgical approaches are currently used for infusion catheter placement. Surgical catheter and pump placement has proved to be a reliable means of delivering drugs to the liver and has been commonly used for hepatic arterial chemotherapy for metastatic colorectal carcinoma. Meticulous angiographic evaluation of the hepatic vascular anatomy, its variations, and hemodynamics is necessary for correct catheter placement to achieve total liver perfusion without significant extrahepatic perfusion. Satisfactory hepatic perfusion should be documented before drug infusion. Hepatic arterial radionuclide flow imaging with technetium-99m-labeled macroaggregated serum albumin remains the most reliable means of assessing hepatic perfusion following catheter placement. Transcatheter techniques have been used to facilitate catheter placement, to prevent gastrointestinal drug toxicity, and to correct unsatisfactory perfusion following surgical catheter placement.
authors: Department of Radiology, University of Michigan Medical Center, Ann Arbor 48109-0030.
authors: K J
authors: KJ
authors: Cho
authors: J C
authors: JC
authors: Andrews
authors: D M
authors: DM
authors: Williams
authors: F
authors: F
authors: Doenz
authors: G E
authors: GE
authors: Guy
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002404:Catheterization / Q000379:methods; D006439:Hemodynamics; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006801:Humans; D007260:Infusion Pumps; D007261:Infusions, Intra-Arterial / Q000009:adverse effects / Q000379:methods; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D011859:Radiography
chemical_list: D000970:Antineoplastic Agents