title: Effect of various propofol plasma concentrations on regional myocardial contractility and left ventricular afterload.
abstract: The cardiovascular effects of propofol infusions, designed to maintain constant plasma concentrations, were examined in an open-chested pig model. Regional myocardial contractility was measured with the end-systolic pressure-length relationship (Ees) and left ventricular afterload quantified by the effective arterial elastance (Ea). The propofol plasma concentrations in this study varied between 0 and 7.73 (SEM 0.96) micrograms/mL. A significant correlation for the increasing propofol plasma concentration and a decrease in myocardial contractility (P = 0.0056) was demonstrated, and the Ea remained constant. This gave rise to a reduction in stroke volume (P = 0.002) and, combined with a decrease in the heart rate (P = 0.0001), led to a reduction in the cardiac output (P = 0.0001). When the propofol infusion was stopped, myocardial contractility did not recover in parallel with the decrease in plasma propofol concentration.
authors: Department of Anesthesiology, University of Stellenbosch Medical School, Tygerberg, South Africa.
authors: A
authors: A
authors: Coetzee
authors: P
authors: P
authors: Fourie
authors: J
authors: J
authors: Coetzee
authors: E
authors: E
authors: Badenhorst
authors: A
authors: A
authors: Rebel
authors: C
authors: C
authors: Bolliger
authors: R
authors: R
authors: Uebel
authors: C
authors: C
authors: Wium
authors: C
authors: C
authors: Lombard
mesh_terms: D000777:Anesthetics / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D003201:Computers; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D007262:Infusions, Intravenous; D009200:Myocardial Contraction / Q000187:drug effects*; D010636:Phenols / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D015742:Propofol; D013552:Swine
chemical_list: D000777:Anesthetics; D010636:Phenols; D015742:Propofol