title: Correlation of tonography and constant pressure perfusion measurements of outflow facility in the rabbit.
abstract: The values of aqueous outflow facility, determined using tonography and constant pressure perfusion, were compared in the New Zealand white rabbit. Four-minute indentation tonography was followed by multi-level constant pressure perfusion lasting 60 minutes in one randomly chosen eye of each animal. Mean outflow facility was 0.26 +/- 0.07 microliter/(min) (mmHg) using tonography and 0.26 +/- 0.6 microliter/(min) (mmHg) using constant pressure perfusion. These values are similar (p greater than 0.6) and show significant correlation (r = 0.914, p less than 0.001). Constant pressure perfusion was associated with a time-dependent facility increase, and with increased flow and stable resistance at higher infusion pressures. These results suggest that tonography may represent a repeatable, reproducible, and valid noninvasive technique to monitor outflow facility in this animal. This may be important in the evaluation of medications which alter wound healing after glaucoma filter surgery.
authors: Department of Ophthalmology, University of Pittsburgh, PA 15213.
authors: S
authors: S
authors: Fourman
authors: M B
authors: MB
authors: Fourman
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000378:metabolism; D001082:Aqueous Humor / Q000378:metabolism; D005069:Evaluation Studies as Topic; D010477:Perfusion; D011817:Rabbits; D014065:Tonometry, Ocular