[In vitro bactericidal effect of a piperacillin-pefloxacin combination against isolated strains of nosocomial pneumopathies in intensive care].
Combinations of piperacillin and pefloxacin are evaluated in vitro using checkerboard and killing-curves methods against 19 clinical isolates: S. aureus, K. pneumoniae, K. oxytoca, C. freundii, P. stuartii, Ps. aeruginosa, Ps. maltophilia and Ac. anitratum. The static checkerboard method showed more synergistic antibacterial effects than the killing curves method. The best synergistic effects appeared against S. aureus, K. oxytoca, P. stuartii, Ps. aeruginosa Ac. anitratum, including a notable increase of the rapidity of bactericidal activity. The combination PIP 64 micrograms - PEF 4 micrograms prevents the frequent secondary regrowth seen after 6 hours with the antibiotics used alone. No activity is obtained against S. aureus meti-R and Ps. maltophilia.
Simeon De Buochberg
M
M
Laboratoire de Bactériologie, Faculté de Pharmacie, Montpellier.
Kassis
J
J
Perez
C
C
Attisso
M
M
Beziau
H
H
Jonquet
O
O
Bertrand
A
A
Pochet
I
I
D003428:Cross Infection / Q000209:etiology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015366:Pefloxacin / Q000494:pharmacology*; D010878:Piperacillin / Q000494:pharmacology*
D015366:Pefloxacin; D010878:Piperacillin
Activité bactéricide in vitro de l'association pipéracilline-péfloxacine sur des souches isolées de pneumopathies nosocomiales en réanimation.