The effect of immunomodulating drugs on adjuvant-induced arthritis in Lewis rats.
The purpose of this study was to investigate the effects of cyclosporine A (CSA) and methotrexate (MTX) as potential immunomodulators in a nonestablished adjuvant arthritis (AA) model. Non-injected hind paw volumes were reduced when AA rats were treated for 18 days with CSA (100% at 10 mg/kg) or MTX (100% at 0.1 mg/kg). Body weights of drug treated AA rats were increased above untreated AA rats and were similar to non-arthritic controls. AA rats show elevated T helper (W3/25+)/T suppressor (OX 8+) cell ratios (2.0 vs. 3.1, p less than 0.01). The immunomodulators tested all returned these elevated ratios to control non-arthritic levels. Similarly, these drugs returned the reduced mitogen responses and elevated blood granulocyte numbers toward normal non-arthritic control values.
Jaffee
B D
BD
E. I. Du Pont de Nemours & Co., Medical Products Department, Wilmington, DE 19880-0400.
Kerr
J S
JS
Jones
E A
EA
Giannaras
J V
JV
McGowan
M
M
Ackerman
N R
NR
D000818:Animals; D001168:Arthritis; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D003524:Cyclosporins / Q000627:therapeutic use; D005528:Foot / Q000473:pathology; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D007213:Indomethacin; D008727:Methotrexate