title: Antitumor effects of rhodium (II) citrate in mice bearing Ehrlich tumors.
abstract: Rhodium II citrate was tested in mice for acute toxicity, antitumoral activity against Ehrlich ascites carcinoma and inhibition of DNA synthesis by Ehrlich tumor, malignant adrenocortical cells (Y-1) and normal adrenocortical cells (AR-1). At ip doses up to 260 mg/kg, the compound had no toxic effects for up to 14 days. The same total dose given over 4 days significantly increased the survival rate of mice bearing Ehrlich ascites cells. Thymidine incorporation by Ehrlich tumor, Y-1 and AR-1 cells in vitro was inhibited 50% by 0.1 to 0.2 mM concentrations of the compound. We conclude that the increased survival of the tumor-bearing mice was due at least in part to the inhibition of DNA synthesis with a consequent reduction of cell division and tumor growth.
authors: Departamento de Farmacologia, Universidade de São Paulo, Brasil.
authors: S
authors: S
authors: Zyngier
authors: E
authors: E
authors: Kimura
authors: R
authors: R
authors: Najjar
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000401:mortality / Q000473:pathology*; D002951:Citrates / Q000494:pharmacology* / Q000633:toxicity; D004247:DNA / Q000096:biosynthesis*; D051379:Mice; D012238:Rhodium / Q000494:pharmacology* / Q000633:toxicity; D013936:Thymidine / Q000378:metabolism
chemical_list: D002951:Citrates; D004247:DNA; D012238:Rhodium; D013936:Thymidine