title: New natural polysaccharides with potent antithrombic activity: fucans from brown algae.
abstract: Fucans extracted from brown algae exhibit anticoagulant properties, as demonstrated by coagulation assays and kinetic study of the inactivation of thrombin in the presence of antithrombin III. These derivatives exert a direct antithrombic activity by an antithrombin III-independent pathway. Besides, their anticoagulant activity is not mediated by a potency to inhibit factor Xa. Relatively low-molecular-mass fractions (50,000 Daltons) prepared by chromatographic fractionation of the crude fucans also exhibit anticoagulant activity. They may prove useful as anticoagulant drugs.
authors: Laboratoire de Recherches sur les Macromolécules, CNRS UA 502, Université Paris-Nord, Villetaneuse, France.
authors: V
authors: V
authors: Grauffel
authors: B
authors: B
authors: Kloareg
authors: S
authors: S
authors: Mabeau
authors: P
authors: P
authors: Durand
authors: J
authors: J
authors: Jozefonvicz
mesh_terms: D000990:Antithrombin III / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D056890:Eukaryota / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008970:Molecular Weight; D000459:Phaeophyceae / Q000378:metabolism*; D010936:Plant Extracts / Q000378:metabolism / Q000494:pharmacology; D011134:Polysaccharides / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors*
chemical_list: D010936:Plant Extracts; D011134:Polysaccharides; D000990:Antithrombin III; C007789:fucoidan; D013917:Thrombin