title: Microbiological evaluation of MiraFlow.
abstract: The antimicrobial activity of MiraFlow, an extra-strength cleaner containing 20% isopropyl alcohol, was evaluated using various microorganisms including Acanthamoeba. Other leading cleaners, disinfecting solutions and heat were evaluated for comparison. MiraFlow had greater antimicrobial activity than the other cleaning solutions against all five test microorganisms. When evaluated against Acanthamoeba castellanii, MiraFlow was significantly better than disinfecting solutions containing 3% hydrogen peroxide, with D-values of less than 12 seconds and 1 hour, respectively. Thermal disinfection of Acanthamoeba cysts occurred rapidly at temperatures above 60 degrees C. The data suggest that either thermal disinfection or cleaning lenses for 20 seconds with MiraFlow followed by disinfection in an amoebacidal solution such as 3% hydrogen peroxide, should inactivate Acanthamoeba cysts found as chance contaminants on lenses.
authors: Genelabs, Inc., Redwood City, CA 94063.
authors: M
authors: M
authors: Ghajar
authors: R D
authors: RD
authors: Houlsby
authors: G
authors: G
authors: Chavez
mesh_terms: D000433:1-Propanol / Q000494:pharmacology; D000890:Anti-Infective Agents; D003261:Contact Lenses; D004203:Disinfection; D006358:Hot Temperature; D006861:Hydrogen Peroxide; D009883:Ophthalmic Solutions; D011092:Polyethylene Glycols / Q000494:pharmacology; D011126:Polypropylenes / Q000494:pharmacology; D013242:Sterilization; D013501:Surface-Active Agents / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D009883:Ophthalmic Solutions; D011126:Polypropylenes; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; D000433:1-Propanol; D006861:Hydrogen Peroxide