[Role of the collateral coronary circulation in the mechanism of action of verapamil and diltiazem on the ischemic myocardium].
In experiments on anesthetized cats and dogs it was shown that the anti-ischemic action of verapamil and diltiazem injected intravenously in acute permanent occlusion of the coronary artery is not related to their effect on the collateral blood supply to the myocardial ischemic focus. The protective effect of the drugs in this case is due to other mechanisms one of which is a decrease of oxygen consumption by the heart.
Kirsanova
G Iu
GIu
Tsorin
I B
IB
Chichkanov
G G
GG
D000818:Animals; D002415:Cats; D003097:Collateral Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004110:Diltiazem / Q000627:therapeutic use*; D004285:Dogs; D010101:Oxygen Consumption / Q000187:drug effects; D014700:Verapamil / Q000627:therapeutic use*
D014700:Verapamil; D004110:Diltiazem
Rol' kollateral'nogo koronarnogo krovoobrashcheniia v mekhanizme deĭstviia verapamila i diltiazema na ishemizirovannyĭ miokard.