Evaluation of two forms of N-benzoyl-L-tyrosyl p-aminobenzoic acid in pancreatic function testing of dogs.
Plasma para-aminobenzoic acid (PABA) concentrations were compared in 12 dogs after oral administration of either a powdered suspension or a solution of N-benzoyl-L-tyrosyl-PABA. Peak PABA plasma concentrations were significantly higher at 30, 60 and 90 minutes after administration of the solution (P less than 0.05). As the solution may now be used as a clinical test, interpretation of the results by comparison with normal absorption curves obtained after administration of the suspension could contribute to a failure to diagnose canine exocrine pancreatic insufficiency.
Burrows
C F
CF
College of Veterinary Medicine, Department of Medical Sciences, HSC University of Florida, Gainesville 32610.
Orfely
C
C
D010129:4-Aminobenzoic Acid / Q000097:blood*; D062365:Aminobenzoates / Q000097:blood*; D000818:Animals; D004285:Dogs / Q000502:physiology*; D010179:Pancreas / Q000502:physiology; D010186:Pancreatic Function Tests / Q000662:veterinary*; D062366:para-Aminobenzoates
D062365:Aminobenzoates; D062366:para-Aminobenzoates; C006717:bentiromide; D010129:4-Aminobenzoic Acid