[Modifying effect of the blood serum from patients with soft-tissue sarcomas on interleukin-2 production and activity].
Interleukin-2 (IL-2) production by lymphocytes of a peripheral blood (LPB) in patients with soft tissue sarcomas is considerably lower in comparison with that in donors. Autological serum had either suppressive or stimulative effect on LPB IL-2 production in the observed patients. The investigated serum affected LPB of donors in the same way. Serum of patients with soft tissue sarcomas had the same dual effect on the ability of the active drug IL-2 to proliferate human T-lymphoblasts. Moreover serum-inhibitors of production acted as IL-2 activity stimulators, while serum-stimulators of IL-2 production inhibited the mediator effects.
Goretskiĭ
B A
BA
Berezhnaia
N M
NM
Palivets
A Iu
AIu
Konovalenko
V F
VF
D001782:Blood Donors; D002478:Cells, Cultured; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000276:immunology; D012509:Sarcoma / Q000276:immunology*; D012983:Soft Tissue Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D007106:Immune Sera; D007376:Interleukin-2
Modifitsiruiushchee vliianie syvorotki krovi bol'nykh sarkomami miagkikh tkaneĭ na produktsiiu i aktivnost' interleĭkina-2.