title: Contribution of plasma protein and lipoproteins to intestinal lymph: comparison of long-chain with medium-chain triglyceride duodenal infusion.
abstract: In rats with intestinal lymph-fistula and electrolyte and protein losses continuously replaced by I.V. infusion, the plasma to lymph filtration of total protein, albumin, and cholesterol was similar after duodenal infusion of either long-chain (LCT) or medium-chain (MCT) triglyceride. Filtration of cholesterol into intestinal lacteals was also measured after pulsed I.V. administration of 14C-beta-sitosterol as an indirect marker for passage of lipoproteins into the lymph system. During intraduodenal administration of LCT and constant I.V. infusion of 125I-apo high density lipoprotein (HDL), intact plasma HDL appeared in lymph and contributed apo-LP to chylomicron formation. Nevertheless, most lymph apo-LP originated from local mucosal synthesis.
authors: Clinics Hospital Laboratory Investigation Institute (LIM), University of São Paulo, Brazil.
authors: A M
authors: AM
authors: Sipahi
authors: H C
authors: HC
authors: Oliveira
authors: K S
authors: KS
authors: Vasconcelos
authors: L N
authors: LN
authors: Castilho
authors: A
authors: A
authors: Bettarello
authors: E C
authors: EC
authors: Quintão
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002784:Cholesterol / Q000378:metabolism*; D004386:Duodenum / Q000378:metabolism; D007262:Infusions, Intravenous; D007413:Intestinal Mucosa / Q000378:metabolism*; D008074:Lipoproteins / Q000378:metabolism*; D008196:Lymph / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012855:Sitosterols; D014280:Triglycerides / Q000493:pharmacokinetics*
chemical_list: D001798:Blood Proteins; D002250:Carbon Radioisotopes; D008074:Lipoproteins; D012855:Sitosterols; D014280:Triglycerides; C025473:gamma-sitosterol; D002784:Cholesterol