[Early indicators of kidney injury in male and female rats after oral administration of cadmium].
The effect of cadmium on the urinary excretion of glucose, creatinine and enzymes has been studied in adult male and female rats given the substance (70, 140 and 280 mg/kg food) for 4 weeks. Renal function tests and gel electrophoresis of urinary proteins were conducted simultaneously. Sex-dependent differences were demonstrated with regard to sensitivity of several kidney parameters and their predictive character of a possible chronic nephrotoxicity. These results were compared with hematological and general biological examinations of cadmium toxicity.
Ozierenski
B
B
Zentralinstitut für Ernährung in Potsdam-Rehbrücke, Akademie der Wissenschaften der DDR.
Plass
R
R
Lewerenz
H J
HJ
D000818:Animals; D002105:Cadmium Poisoning / Q000503:physiopathology*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D007674:Kidney Diseases / Q000139:chemically induced* / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D011507:Proteinuria / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013997:Time Factors
Erfassung frühzeitiger Nierenschädigungen anhand von Urinuntersuchungen an männlichen und weiblichen Ratten nach oraler Cadmiumexposition.