[Immunosuppressive and virostatic actions of sterones from Petunia hybrida Vilm].
10 Ergostan-3-on derivatives presumably in the majority ergosta-1,4-dien-3-on derivatives could be isolated from Petunia hybrida VILM. Two were identified as the known compounds petuniasterone A and petuniasterone-C-22-O-acetate. The structures of two other compounds named petuniasterone-D-diacetate and 30-hydroxypetuniasterone A could be elucidated. The molecular formulas of the remaining substances were ascertained by mass spectroscopy. The petuniasterones inhibited the proliferation of stimulated human lymphocytes in non-cytotoxic concentrations, possessing therefore possibly immunosuppressive effects. Extracts of the plant and fractions containing a synergistically effective blue fluorescing substance retarded the multiplication speed of influenza viruses; pure petuniasterones were ineffectiv under our conditions in this regard.
Hassan
R
R
Sektion Pharmazie, Ernst-Moritz-Arndt-Universität Greifswald.
Teuscher
E
E
Gründemann
E
E
Franke
P
P
Hiller
K
K
May
A
A
Mahmood
S
S
D000998:Antiviral Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D013058:Mass Spectrometry; D010946:Plants, Medicinal / Q000032:analysis*
D000998:Antiviral Agents; D007166:Immunosuppressive Agents; C061458:petuniasterone A; C061459:petuniasterone-C22-O-acetate; D004875:Ergosterol
Untersuchungen immunsuppressiv und virostatisch wirksamer Sterone aus Petunia hybrida Vilm.