Transdermal controlled delivery of propranolol from a multilaminate adhesive device.
The feasibility of transdermal controlled delivery of propranolol was investigated by conducting in vitro skin permeation studies using rabbit pinna (ear) skin. A new multilaminate adhesive device which is capable of releasing propranolol in a controlled fashion over a 24-hr period had been developed and was evaluated transdermally using rabbit pinna skin. Skin permeation of propranolol from the device was found to be controlled by the stratum corneum during the early phase of permeation and then by the adhesive device during steady-state permeation. The rabbit pinna skin was shown to be a good animal model for studying the transdermal permeation of propranolol from the device, when compared to human cadaver skin.
Corbo
M
M
Controlled Drug-Delivery Research Center, Rutgers University College of Pharmacy, Piscataway, New Jersey 08855-0789.
Liu
J C
JC
Chien
Y W
YW
D000269:Adhesives; D000279:Administration, Cutaneous; D000818:Animals; D004431:Ear, External / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D011433:Propranolol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011817:Rabbits; D051381:Rats; D012828:Silicones; D012869:Skin Absorption; D013045:Species Specificity; D013535:Suspensions
D000269:Adhesives; D012828:Silicones; D013535:Suspensions; D011433:Propranolol