[The carcinogenic effect of 5-bromodeoxyuridine and its amplification by x-rays in rats].
5-bromodeoxyuridine (BUdR) injected to rats in the neonatal period is shown to produce a pronounced carcinogenic effect which brings about the appearance of various benign and malignant tumours. Exposure of females to X-ray total-body irradiation (1.5 Gy) was followed by intensification of the carcinogenic effect of BUdR. Assuming that this pyrimidine analog reacts solely with DNA substituting thymidine during DNA synthesis and induces point mutations due to tautomerization, the data obtained demonstrate the possibility of tumour induction by a selective DNA perturbation.
Anisimov
V N
VN
Likhachev
A Ia
AIa
Vilenchik
M M
MM
D000818:Animals; D001973:Bromodeoxyuridine / Q000528:radiation effects / Q000633:toxicity*; D003043:Cocarcinogenesis; D004249:DNA Damage; D005260:Female; D008297:Male; D009381:Neoplasms, Radiation-Induced; D051381:Rats; D014965:X-Rays
D001973:Bromodeoxyuridine
Kantserogennyĭ éffekt 5-bromodezoksiuridina i ego usilenie rentgenovskim oblucheniem u krys.