Cytotoxic T-cell response to influenza A subunit vaccine in patients with type 1 diabetes mellitus.
The cytotoxic T-cell and humoral immune response to a commercially available influenza A-H1N1 subunit vaccine in 14 patients with type 1 diabetes mellitus was compared with the response in 13 healthy volunteers. Cytotoxic T-cell response to vaccination was poor in both patients and controls. At a calculated 50: 1 effector-target cell ratio, however, significantly more controls than patients showed an increase of over 5% cytotoxic T-cell mediated lysis after vaccination (P less than 0.05). In patients the cytotoxic T-cell response decreased with higher percentages of glycosylated haemoglobin (regression coefficient not equal to 0 with P less than 0.05). No significant difference was found between diabetic patients and control subjects with respect to antibody response after vaccination. Implications for vaccination strategy are discussed.
Diepersloot
R J
RJ
Bouter
K P
KP
van Beek
R
R
Lucas
C J
CJ
Masurel
N
N
Erkelens
D W
DW
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
D000914:Antibodies, Viral; D007252:Influenza Vaccines