Cytogenetic survey of subfertile males in Japan.
Chromosomal analysis of 554 consecutive Japanese male patients attending a subfertility clinic revealed 18 (3.2%) major chromosomal aberrations. The incidence of sex chromosomal anomalies and autosomal anomalies is 1.3 and 2.0%, respectively, which is significantly higher than that for the general population. All 7 sex chromosomal anomalies were found among the azoo- or oligozoospermic patients, while the incidence of autosomal anomalies for the normozoospermic patients was statistically similar to that for the azoo- or oligozoospermic patients. Therefore, cytogenetic analysis is recommended not only for patients with reduced sperm density but also for subfertile patients with normozoospermia.
Matsuda
T
T
Department of Urology, Faculty of Medicine, Kyoto University, Japan.
Nonomura
M
M
Okada
K
K
Hayashi
K
K
Yoshida
O
O
D000328:Adult; D002869:Chromosome Aberrations; D006801:Humans; D015994:Incidence; D007248:Infertility, Male / Q000453:epidemiology / Q000235:genetics*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012729:Sex Chromosome Aberrations / Q000453:epidemiology*