[Effects of inhalation of several organic solvents on left ventricular dp/dt].
Effects of inhalation of several organic solvents on left ventricular contractility were investigated by using left ventricular dp/dt in anesthetized dogs. The first derivative of the left ventricular pressure was obtained by an electronic differentiating circuit and recorded continuously. As organic solvents, 1,1,1-trichloroethane (1,1,1-TCE), trichloroethylene, tetrachloroethylene, toluene, m-xylene and trichloro-trifluoroethane (FC-113) were used in this study. Each solvent was separately inhaled for a period of approximately 2 min. In the acute inhalation experiments, peak dp/dt that was the maximal left ventricular dp/dt decreased following inhalation of each organic solvent. The threshold concentration of 1,1,1-TCE, trichloroethylene, tetrachloroethylene, toluene, m-xylene and FC-113 required to decrease peak dp/dt was approximately 0.2%, 0.15%, 0.2%, 0.38%, 0.35% and 0.35%, respectively. These results indicated that the decrease in peak dp/dt was induced following inhalation of each solvent, but threshold concentration of the solvents to produce decrease in peak dp/dt was different. Inhalation of organic solvents of higher concentrations markedly decrease peak dp/dt. A dose response relationship was observed between decrease in peak dp/dt and concentration of the solvent greater than the threshold level. The degree of decrease in peak dp/dt following inhalation differed by kind of solvents with the greatest decrease in peak dp/dt being induced by tetrachloroethylene inhalation.
Kobayashi
H
H
Department of Public Health, Yamaguchi University School of Medicine.
Hobara
T
T
Sakai
T
T
D000280:Administration, Inhalation; D000818:Animals; D064227:Chlorofluorocarbons, Ethane; D005617:Chlorofluorocarbons, Methane / Q000633:toxicity; D004285:Dogs; D009200:Myocardial Contraction / Q000187:drug effects*; D012997:Solvents / Q000008:administration & dosage / Q000633:toxicity*; D013750:Tetrachloroethylene / Q000633:toxicity; D014050:Toluene / Q000633:toxicity; D014240:Trichloroethanes / Q000633:toxicity; D014241:Trichloroethylene / Q000633:toxicity; D014992:Xylenes / Q000633:toxicity
D064227:Chlorofluorocarbons, Ethane; D005617:Chlorofluorocarbons, Methane; D012997:Solvents; D014240:Trichloroethanes; D014992:Xylenes; C005850:1,1,1-trichloro-2,2,2-trifluoroethane; C024566:1,1,1-trichloroethane; D014241:Trichloroethylene; D014050:Toluene; C031285:3-xylene; D013750:Tetrachloroethylene