UK-69,753, a novel member of the efrotomycin family of antibiotics. I. Taxonomy of the producing organism, fermentation and isolation.
UK-69,753 is a novel antibiotic structurally related to efrotomycin and factumycin, produced by a new strain of Amycolatopsis orientalis (ATCC 53550). The antibiotic potency in the fermentation broth was monitored by HPLC with diode array detection. A six tube counter current distribution was used to purify UK-69,753.
Pacey
M S
MS
Central Research Division, Pfizer Ltd., Kent, England.
Jefson
M R
MR
Huang
L H
LH
Cullen
W P
WP
Maeda
H
H
Tone
J
J
Nishiyama
S
S
Kaneda
K
K
Ishiguro
M
M
D000192:Actinomycetales / Q000145:classification / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D011714:Pyrans / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D011714:Pyrans; C058298:UK 69753