title: Lymphocyte subpopulations in the blood of sheep persistently infected with border disease virus.
abstract: The surface phenotypes of peripheral blood lymphocytes in groups of lambs and adult sheep persistently infected with Border disease virus (P-I BD) were compared with those of healthy controls. The proportion and number of lymphocytes bearing surface immunoglobulin (sIg+) and expressing class II MHC antigen (B cells) were significantly increased. A significant increase in CD1+ lymphocytes was also evident. Conversely, the proportion of T lymphocytes in P-I BD lambs was reduced. A marked reduction in the proportion of circulating lymphocytes expressing class I MHC antigen was also observed. These findings were not affected by differences in the strain of the virus responsible for the persistent infection.
authors: Moredun Research Institute, Edinburgh, Scotland.
authors: C
authors: C
authors: Burrells
authors: P F
authors: PF
authors: Nettleton
authors: H W
authors: HW
authors: Reid
authors: H R
authors: HR
authors: Miller
authors: J
authors: J
authors: Hopkins
authors: I
authors: I
authors: McConnell
authors: M D
authors: MD
authors: Gorrell
authors: M R
authors: MR
authors: Brandon
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes; D001882:Border Disease / Q000097:blood / Q000276:immunology*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000145:classification*; D010641:Phenotype; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification
chemical_list: D000911:Antibodies, Monoclonal