Ability of alpha (but not beta) form interleukin-1 to support DNA synthesis in human tonsillar B cells.
The ability of the two forms of recombinant human interleukin-1 (alpha and beta) to support DNA synthesis in human tonsillar B cells was assessed. The results suggested that in two out of three cases the alpha form was able to support DNA synthesis when the beta form was not. These results support the hypothesis that each form of human interleukin-1 has a different role in supporting the growth of human B cells.
Gallagher
G
G
Immunology Division, University of Strathclyde, Glasgow, Scotland.
Christie
J F
JF
Stimson
W H
WH
D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000502:physiology; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D014066:Palatine Tonsil; D011994:Recombinant Proteins / Q000494:pharmacology
D007375:Interleukin-1; D011994:Recombinant Proteins; D004247:DNA