Leukopenia in acute thermal injury: evidence against topical silver sulfadiazine as the causative agent.
White blood cell data from time of admission to 4 days after burn injury was retrospectively reviewed to determine differences in the incidence of leukopenia in patients with burn injuries treated topically with either silver sulfadiazine or silver nitrate. WBC counts decreased in both groups of patients during the first 3 days after burn injury. An incidence of leukopenia (WBC count less than or equal to 5000/mm3) was observed in of 40 (47.5%) patients treated with silver sulfadiazine and in 13 of 30 (43.3%) patients treated with silver nitrate. There was no statistical difference in the incidence of leukopenia between the two treatment groups. These data suggest that silver sulfadiazine may not be the cause of the leukopenia observed early after burn injury.
Thomson
P D
PD
Department of Surgery, University of Michigan Medical Center, Ann Arbor.
Moore
N P
NP
Rice
T L
TL
Prasad
J K
JK
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002056:Burns / Q000150:complications / Q000188:drug therapy*; D002648:Child; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D007970:Leukopenia / Q000139:chemically induced* / Q000150:complications; D008297:Male; D008875:Middle Aged; D012835:Silver Nitrate / Q000627:therapeutic use; D012837:Silver Sulfadiazine / Q000009:adverse effects*; D013411:Sulfadiazine / Q000009:adverse effects*
D013411:Sulfadiazine; D012835:Silver Nitrate; D012837:Silver Sulfadiazine