[Effect of thiamine and its metabolites on aspartate and alanine aminotransferase activity in the body of white rats and in donor blood].
ThPP and thiochrome, being thiamine metabolites, are inhibitors of blood transaminase. Their action is evidently realized on the level of competition with PALP when these compounds attach to apotransaminases.
Petrov
S A
SA
Donesko
E V
EV
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D001782:Blood Donors; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D051381:Rats; D013831:Thiamine / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D013831:Thiamine
Vliianie tiamina i ego metabolitov na aktivnost' aspartat- i alaninaminotransferazy v organizme belykh krys i donorskoĭ krovi.