Influence of pharmacological doses of calcitonin on serum osteocalcin concentration in patients with Paget's disease of the bone.
The effect of continuous infusion of calcitonin on serum osteocalcin concentration was studied in 14 patients with Paget's disease. In all patients serum osteocalcin was initially increased. Within 24 h calcitonin gradually reduced serum osteocalcin, a marker of osteoblastic activity. This means that inhibition of the function of the osteoclasts by calcitonin results in an inhibition of the osteoblasts within 24 h in patients with Paget's disease.
Mulder
H
H
Department of Internal Medicine, Eudokia Hospital, Rotterdam, The Netherlands.
Schop
C
C
Koster
J C
JC
D000368:Aged; D002116:Calcitonin / Q000008:administration & dosage* / Q000494:pharmacology; D002135:Calcium-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000097:blood* / Q000188:drug therapy; D015675:Osteocalcin
D002135:Calcium-Binding Proteins; D015675:Osteocalcin; D002116:Calcitonin