Campylobacter pylori-related gastrointestinal disease in children. Incidence and clinical findings.
Over a one-year period, 95 children and adolescents presenting with epigastric pain and/or vomiting, and without associated risk factors for development of peptide disease, underwent endoscopic antral biopsies for pathologic diagnosis and to detect presence of Campylobacter ss. pylori (C. pylori). Additional biopsies of the esophagus, stomach, and duodenum were obtained for histologic evaluation. C. pylori was identified in 16 patients (16.8%), all of whom had evidence of acute and/or chronic gastritis. Significant discriminating factors between C. pylori-positive and -negative subjects included age at presentation (positive vs negative = 14.6 vs 9.9 years, P less than 0.01), biopsy-confirmed gastritis (100% vs 30.4%, P less than 0.001), and diagnosis of duodenitis alone (0% vs 46.8%, P less than 0.001). Risk for bacterial colonization was significantly higher in the presence of endoscopic gastritis (P less than 0.001). Among C. pylori-positive patients, none responded to standard antiulcer therapy (H2-receptor antagonists, antacids). Symptomatic and histologic remission was achieved utilizing combined therapy with bismuth subsalicylate and antibiotics. Seven of 79 C. pylori-negative patients with biopsy-proven gastritis who responded poorly to antisecretory therapy had the organism identified in follow-up antral biopsies; these patients improved clinically following treatment for C. pylori. These data suggest that C. pylori is a significant factor in the etiology of upper gastrointestinal tract inflammatory disease in pediatrics, and presence of the organism should be evaluated, particularly in children with evidence of acute and/or chronic gastritis.
Glassman
M S
MS
Department of Pediatrics, New York Medical College, Valhalla 10595.
Schwarz
S M
SM
Medow
M S
MS
Beneck
D
D
Halata
M
M
Berezin
S
S
Newman
L J
LJ
D000293:Adolescent; D001706:Biopsy; D002169:Campylobacter Infections / Q000453:epidemiology*; D002648:Child; D004382:Duodenitis / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D004724:Endoscopy; D005753:Gastric Mucosa / Q000382:microbiology; D005756:Gastritis / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D011446:Prospective Studies