Species-specific placental corticotropin releasing hormone messenger RNA and peptide expression.
The human placenta is a major site of synthesis of the hypothalamic neuropeptide corticotropin releasing hormone (CRH). We have examined placentae of several other species for expression of the CRH gene in this tissue. CRH mRNA was detected in human, gorilla, and rhesus monkey placentae, but not in rat, guinea pig and lemur placentae. A nonhuman primate may therefore be a suitable experimental model for studying placental CRH gene expression in vivo.
Robinson
B G
BG
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Arbiser
J L
JL
Emanuel
R L
RL
Majzoub
J A
JA
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D006071:Gorilla gorilla; D006168:Guinea Pigs; D006801:Humans; D015151:Immunoblotting / Q000379:methods; D007900:Lemur; D008253:Macaca mulatta; D010926:Placental Hormones / Q000235:genetics*; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis*; D011863:Radioimmunoassay; D051381:Rats
D010926:Placental Hormones; D012333:RNA, Messenger; D003346:Corticotropin-Releasing Hormone