[Myocardial refractory changes after single intravenous administration of cordarone (electrophysiologic study of the heart)].
In 29 patients with cardiac arrhythmias, refractory periods (RP) of the atrium, atrioventricular node and ventricle were defined before and after intravenous administration of cordarone in a dose of 5 mg/kg body weight. The effective RP (ERP) of the atrio-ventricular node showed the most profound changes: in 73% of the patients, the increase was 22.8% as compared to the pretreatment value. The most response of atrial RP to cordarone was also an increase of right atrial ERP by an average of 16.5%, FRP, by 13.1% versus the baseline values. The least effect was produced by cordarone on ventricular RP, namely the maximal increase in right ventricular FRP and ERP did not exceed 10%, but these parameters remained unchanged in a third of the patients.
Grishkin
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D000638:Amiodarone / Q000008:administration & dosage*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000503:physiopathology; D001283:Atrioventricular Node / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D006325:Heart Atria / Q000187:drug effects / Q000503:physiopathology; D006329:Heart Conduction System / Q000503:physiopathology*; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D007275:Injections, Intravenous; D008297:Male
D000638:Amiodarone
Izmeneniia refrakternosti miokarda pri razovykh vnutrivennykh vvedeniiakh kordarona.