[Lymphocyte subpopulations in patients with viral hepatitis B and delta-infections].
Changes in subpopulations of T3, T4, T8, HNK-1, Ia-positive, B-IgM and B-IgG producing lymphocytes were studied in patients with acute and chronic active virus hepatitis B and delta infection. A decrease of T4-helpers/inducers was demonstrated in all the groups under study and of T3-lymphocytes only in patients with delta-hepatitis turning into liver cirrhosis. The number of suppressors/cytotoxic T8 cells increased and T4/T8 ratio decreased in most patients. The number of HNK-1, Ia-positive, B-IgM and B-IgG lymphocytes increased in many subjects examined. Most marked quantitative changes in lymphocyte subpopulations were observed in patients with severe forms of delta-hepatitis and with liver cirrhosis. Changes in lymphocyte subpopulations in patients with viral hepatitis B and delta-infection are explained by reconstruction of the immune system in response to infection, affection of lymphocytes with viruses and emergence of antilymphocyte antibodies.
Savitskiĭ
G I
GI
Zhilina
N N
NN
Morgunov
K V
KV
Bugaeva
N P
NP
Khlopova
I N
IN
D000956:Antigens, Viral / Q000032:analysis; D002908:Chronic Disease; D006509:Hepatitis B / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D003699:Hepatitis D / Q000276:immunology*; D006801:Humans; D007958:Leukocyte Count; D008103:Liver Cirrhosis / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*
D000956:Antigens, Viral; D006514:Hepatitis B Surface Antigens
Subpopuliatsii limfotsitov u bol'nykh virusnym gepatitom B i del'ta-infektsieĭ.