[The specific effects of new phenoxyacetic acid derivatives at the cellular membrane level].
Substances ASFA-2 and ASFA-4, new derivatives of phenoxyacetic acid, induce, in normal conditions, the hyperpolarization of the striated muscle fibre membrane, inhibition the depolarization due to the absence of external Ca2+, the restoration of membrane potential of the liver cells poisoned with ally alcohol and the change of redox potential of the environment. It results that these substances have important pharmacological properties--influence upon the membrane potential and cellular excitability, membrane stabilization, redox modulation and hepatic protection--that can be useful in therapy.
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D000433:1-Propanol / Q000506:poisoning; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology; D002462:Cell Membrane / Q000187:drug effects* / Q000502:physiology; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D006016:Glycolates / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D009132:Muscles / Q000187:drug effects / Q000502:physiology; D010084:Oxidation-Reduction / Q000187:drug effects; D010642:Phenoxyacetates / Q000494:pharmacology*; D020005:Propanols; D011895:Rana ridibunda; D013449:Sulfonamides / Q000494:pharmacology*
D006016:Glycolates; D010642:Phenoxyacetates; D020005:Propanols; D013449:Sulfonamides; C006463:allyl alcohol; C061452:2-chloro-4-sulfonamidophenoxyacetic acid; C061454:4-chloro-2-sulfonamidophenoxyacetic acid; D000433:1-Propanol
Efecte specifice ale unor noi derivaţi ai acidului fenoxiacetic la nivelul membranei celulare.