[Detection of antineutrophil antibodies in patients with neutropenia in infancy].
Antineutrophil antibodies in the sera against peripheral blood neutrophils were examined in 8 infants (2 to 12 months of age) with neutropenia (absolute neutrophil count 0 to 480/microliter). The antibodies were detected by granulocyte indirect immunofluorescence test (GIIFT) and microleukocyte agglutination test (M-LAT). Three of the 6 serum samples with chronic benign-type neutropenia reacted in both GIIFT and M-LAT. In 2 of these 3 samples, the antibody was proved to be specific to neutrophil antigen NA1 by the absorption experiment. Neither the GIIFT nor the M-LAT showed the antibody in two patients with Kostmann-type neutropenia. These results suggest that the examination of antibodies against neutrophils is essential to the evaluation of the patients with chronic benign-type neutropenia in infancy.
Kobayashi
M
M
Yumiba
C
C
Kawaguchi
Y
Y
Tanaka
Y
Y
Ueda
K
K
Komazawa
Y
Y
Kaneda
M
M
Tanihiro
M
M
Okada
K
K
D000380:Agranulocytosis / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007223:Infant; D007519:Isoantigens / Q000276:immunology; D008297:Male; D009503:Neutropenia / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*
D000954:Antigens, Surface; D001323:Autoantibodies; D007519:Isoantigens