[A study on the distribution of T-3262 (tosufloxacin tosilate) in salivary glands of rats using microautoradiography].
The distribution of T-3262 (tosufloxacin tosilate) in salivary glands of rats was investigated with frozen-microautoradiography. One and 4 hours after oral administration of 14C-T-3262 at 100 mg/kg to rats submandibular glands, parotid glands and sublingual glands were removed, and a microautoradiogram of each was made. In the submandibular gland and the parotid gland 14C-T-3262 was distributed at high levels throughout the glands taken at 1 and 4 hours after administration, but lower levels than the other glands were found in the sublingual gland at 1 hour. The results of this study suggested that T-3262 penetrates effectively into the saliva, because 14C-T-3262 is distributed well into glandular acinus, striated duct and excretory duct. The microautoradiography was a useful and reliable method for investigating the distribution of antimicrobial agents in salivary glands.
Morihana
T
T
Department of Oral and Maxillofacial Surgery, School of Medicine, Tokai University.
Sakai
H
H
Hayakawa
H
H
D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D001345:Autoradiography; D004341:Drug Evaluation; D024841:Fluoroquinolones; D008297:Male; D009287:Naphthyridines; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000378:metabolism*
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C055185:tosufloxacin