[The effect of mucous excipient concentration on bioadhesion ex vivo].
The bioadhesion of aqueous solutions of polyacrylics (1-3), hydroxyethylcellulose (4), sodium carboxymethylamylopectin (5), polyvinylalcohol (6) and tragant (7) was investigated using a tensiometer and fresh intestine of pigs. It was dependent on the concentration of the excipient as described by a quadratic equation and found in the maximum from 244 Pa (7) to 554 Pa (4). The maximum of bioadhesion corresponds to the concentration of the excipient from 0.15% (2) to 23.7% (4) and to the viscosity of the solutions from 0.11 Pa.s (3) to 3.6.10(6) Pa.s (4). There was not a correlation between the viscosity and the bioadhesion.
Dittgen
M
M
Sektion Pharmazie der Ernst-Moritz-Arndt-Universität Greifswald.
Oestereich
S
S
Dittrich
F
F
D000268:Adhesiveness; D000818:Animals; D005079:Excipients; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D012044:Regression Analysis; D013552:Swine; D014783:Viscosity
D005079:Excipients
Einfluss der Schleimstoffkonzentration auf die Bioadhäsion ex vivo.