[Discordant evolution in monozygotic twins with familial nephropathy].
Two monozygotic twin sisters presented a familial nephropathy, discovered at 5 years of age. The clinical course was quite different for each patient: end-stage renal failure occurred at 5.5 years of age for one and at 14 years for the other. This difference raises the hypothesis of the role of environmental factors on the clinical expression of an inherited disease.
Falque
V
V
Service de génétique médicale et Laboratoire d'anatomo-pathologie, hôpital d'Enfants de La Timone, Marseille, France.
Casanova
P
P
Barnay
C
C
Picon
G
G
D000293:Adolescent; D000367:Age Factors; D002648:Child; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D016030:Kidney Transplantation; D014427:Twins; D014430:Twins, Monozygotic
Evolution discordante chez deux soeurs jumelles monozygotes atteintes de néphropathie familiale.