Effects of mezerein and diglycerides on the PRL stimulation of cell replication in Nb2 node lymphoma cells.
These studies provide further support for the thesis that the activation of protein kinase C is likely involved in the prolactin (PRL) stimulation of mitogenesis in the Nb2 node lymphoma cell line. The diterpene mezerein is shown to potentiate the mitogenic effect of PRL at a hormone concentration which elicits a less than maximum response. A similar response was observed with two diglycerides, diolein and dicaprin. Neither mezerein nor the diglycerides affected the magnitude of response to a maximum stimulatory concentration of PRL.
Tarrant
T M
TM
Department of Physiology, Wayne State University, School of Medicine, Detroit, Michigan 48201.
Rillema
J A
JA
D002273:Carcinogens / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004075:Diglycerides / Q000494:pharmacology*; D004224:Diterpenes; D004357:Drug Synergism; D004789:Enzyme Activation / Q000187:drug effects; D005989:Glycerides / Q000494:pharmacology*; D007700:Kinetics; D008223:Lymphoma / Q000473:pathology*; D011388:Prolactin / Q000494:pharmacology*; D011493:Protein Kinase C / Q000378:metabolism*; D013729:Terpenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D002273:Carcinogens; D004075:Diglycerides; D004224:Diterpenes; D005989:Glycerides; D013729:Terpenes; C044297:1,2-didecanoylglycerol; C011309:mezerein; C038237:1-oleoyl-2-acetylglycerol; D011388:Prolactin; D011493:Protein Kinase C; C013965:diolein