Effect of phosphate binders on the course of chronic renal failure in rats with focal glomerular sclerosis.
To investigate the effect of phosphate binders on the progress of renal functional deterioration, aluminium hydroxide (AL) or calcium carbonate (CA) was administered to adriamycin (ADR)-induced progressive renal failure model rats. Urinary protein excretion was reduced in ADR rats treated with AL (ADR-AL group) or CA (ADR-CA group), compared to those without the treatment (ADR group). Urinary phosphate excretion, serum phosphate concentration, and calcium-phosphate product were significantly lower in the ADR-AL and ADR-CA groups than in the ADR group. At week 34, increased serum creatinine, glomerular sclerosis and tubulointerstitial alterations, being marked in the ADR group, were ameliorated in the ADR-AL and ADR-CA groups. However, there was no significant difference in body weight and serum total protein among the three groups. We conclude that AL and CA could both prevent chronic progressive renal deterioration in focal glomerular sclerosis induced by ADR, and preserve the nutritional condition.
Sanai
T
T
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Okuda
S
S
Motomura
K
K
Onoyama
K
K
Fujishima
M
M
D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000818:Animals; D002119:Calcium Carbonate / Q000494:pharmacology*; D004317:Doxorubicin; D005921:Glomerulonephritis / Q000503:physiopathology*; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D011507:Proteinuria / Q000503:physiopathology; D051381:Rats; D011917:Rats, Inbred Lew
D000536:Aluminum Hydroxide; D004317:Doxorubicin; D002119:Calcium Carbonate