Correction of thrombocytopenia with small dose aspirin in the primary antiphospholipid syndrome.
We describe 2 patients with primary antiphospholipid syndrome in whom thrombocytopenia, which had not responded to high dose prednisone treatment, was promptly corrected after they started taking small doses (100 mg/day) of aspirin. This effect has been sustained despite subsequent prednisone withdrawal. Theoretical reasons for such an apparent therapeutic effect of aspirin in these patients are discussed.
Alarcón-Segovia
D
D
Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Mexico City, Mexico.
Sánchez-Guerrero
J
J
D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000032:analysis*; D001241:Aspirin / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D010743:Phospholipids / Q000276:immunology*; D013577:Syndrome; D013921:Thrombocytopenia / Q000188:drug therapy*
D000906:Antibodies; D010743:Phospholipids; D001241:Aspirin