Study of HLA antigens in patients with Hodgkin's disease.
This paper studies relations of 21 HLA antigens of the A and B loci to selected characteristics in a group of patients with Hodgkin's disease. The investigated characteristics are age, sex, histological patterns, clinical stage and symptomatology. The considered group consists of 68 patients, 37 males and 31 females aged from 19 to 66 years and from 26 to 63 yr, respectively. A comparison between antigen frequencies for patients and controls (301 unrelated blood donors) is carried out. The results confirm that there is no relation between HLA antigens and Hodgkin's disease. A significant increase of A11 is found for females under 40 yr. Certain HLA antigens show significant correlation neither with the patient age nor with clinical or histological stages. A significant increase of B5 is observed for 16 relapsed patients. For them, significant test characteristics are found in the presence of cross-reacting HLA-B5, B35.
Prazák
J
J
Institute of Haematology and Blood Transfusion, Faculty of General Medicine, Charles University, Prague, Czechoslovakia.
Hermanská
Z
Z
D000328:Adult; D000368:Aged; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis; D059870:HLA-A11 Antigen; D015235:HLA-B Antigens / Q000032:analysis; D015797:HLA-B35 Antigen; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens; D015234:HLA-A Antigens; D059870:HLA-A11 Antigen; D015235:HLA-B Antigens; D015797:HLA-B35 Antigen; C035270:HLA-B5 antigen