title: Calcitonin gene-related peptide increases in rat facial motoneurons after peripheral nerve transection.
abstract: The rat facial nerve was transected and the retrograde reaction studied in the facial nucleus using light and electron microscopic immunohistochemistry and radioimmunoassay for calcitonin gene-related peptide (CGRP). An initial increase of CGRP-immunoreactivity (IR) was noted at 15 h after axotomy, thereafter CGRP-IR continued to rise to maximal levels around day 6 after which it gradually decreased and reached normal levels again after 5-6 weeks. Immunoreactive CGRP was found to fill the perikarya of facial motoneurons extending into dendrites and axons. Possible functional implications of CGRP as a neuroregulatory molecule during nerve regeneration are discussed.
authors: Department of Neuromorphology, Max Planck Institute for Psychiatry, Martinsried, F.R.G.
authors: W J
authors: WJ
authors: Streit
authors: F L
authors: FL
authors: Dumoulin
authors: G
authors: G
authors: Raivich
authors: G W
authors: GW
authors: Kreutzberg
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D003712:Dendrites / Q000378:metabolism / Q000648:ultrastructure; D003714:Denervation; D005154:Facial Nerve / Q000378:metabolism* / Q000601:surgery / Q000648:ultrastructure; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009046:Motor Neurons / Q000378:metabolism* / Q000648:ultrastructure; D009416:Nerve Regeneration; D009457:Neuroglia / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide