Naloxone does not produce withdrawal hypothermia in chronically phencyclidine-treated rats.
Naloxone-induced hypothermia is a sensitive indicator of mu-type opiate dependence in the rat. The present study investigated whether naloxone produces hypothermia in chronically PCP-treated rats. Rats were given daily injections of saline or PCP (10.0 mg/kg s.c.) for 7 days, and on day 8 challenged with naloxone (2.0 mg/kg s.c.). There were no differences between chronic saline- and PCP-treated subjects, indicating that the repeated administration of 10.0 mg/kg per day of PCP does not produce mu-type opiate dependence as reflected by naloxone-precipitated hypothermia.
Pechnick
R N
RN
Department of Pharmacology, UCLA School of Medicine 90024-1735.
George
R
R
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D013997:Time Factors
D009270:Naloxone; D010622:Phencyclidine