[Limitation of ischemic necrosis by the use of antioxidant ionol].
Inhibitory effect of Ionol on lipid peroxidation (LPO) in the infarction zone and out of it after experimental myocardial infarction in the experiments on rats was investigated. The results of measurements, performed by two independent methods: point counting and the computer image analysis were compared. It was shown that LPO activation out of the ischaemic zone was prevented and dimensions of the ischaemic necrosis were limited by Ionol, which did not influence LPO activation in the ischaemic zone. Data obtained by both methods coincide qualitatively, the computer image analysis being more sensitive and effective.
Evsev'eva
M V
MV
Shinkarenko
V S
VS
Didenko
V V
VV
Meerson
F Z
FZ
D000284:Administration, Oral; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage / Q000494:pharmacology*; D002374:Catalase / Q000032:analysis; D005979:Glutathione Peroxidase / Q000032:analysis; D007091:Image Processing, Computer-Assisted; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008954:Models, Biological; D009203:Myocardial Infarction / Q000473:pathology*; D009206:Myocardium / Q000201:enzymology / Q000473:pathology*; D009336:Necrosis; D051381:Rats
D002084:Butylated Hydroxytoluene; D002374:Catalase; D005979:Glutathione Peroxidase
Ogranichenie ishemicheskogo nekroza s pomoshch'iu antioksidanta ionola.