Remission induced by chlorambucil in steroid-responsive, frequently relapsing nephrotic syndrome that relapsed after cyclophosphamide.
Five patients with a steroid-responsive, frequently relapsing nephrotic syndrome who had failed at least one course of treatment with cyclophosphamide were all put into a long term remission with chlorambucil. One patient developed a severe neutropenia and herpes zoster and another with an epileptic tendency developed myoclonic jerks. The indications and potential hazards of using chlorambucil in this context are discussed.
Bailey
R R
RR
Department of Nephrology, Christchurch Hospital.
D000284:Administration, Oral; D002648:Child; D002699:Chlorambucil / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012008:Recurrence; D012074:Remission Induction / Q000379:methods; D013997:Time Factors
D002699:Chlorambucil; D003520:Cyclophosphamide; D011241:Prednisone