Chronic myelocytic leukemia probably promoted by growth hormone.
The study shows clinical evidence that growth hormone (GH) presumably promoted Ph1-positive chronic myelocytic leukemia in a 14-year-old boy who was receiving GH treatment for growth failure after surgery and irradiation for craniopharyngioma. Leukocytosis associated with immature myelocytic cells and low leukocyte alkaline phosphatase score appeared one year after GH treatment. Cytogenic study showed the presence of Ph1 chromosome.
Ishii
A
A
Department of Pediatrics, Saka Hospital, Shiogama.
Kakuta
K
K
Tsuchiya
S
S
Konno
T
T
D000293:Adolescent; D001853:Bone Marrow / Q000473:pathology; D006130:Growth Disorders / Q000188:drug therapy; D013006:Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology*; D007958:Leukocyte Count; D007964:Leukocytosis / Q000209:etiology; D008297:Male; D010677:Philadelphia Chromosome
D013006:Growth Hormone