title: [The study of degradation of peptides in human plasma and serum by the ERIAD high pressure liquid chromatography-mass spectrometry method].
abstract: The proteolysis of bradykinin, [Leu5]enkephalin and some of its synthetic analogs. [D-Ala2,Leu5]enkephalin and [D-Ala2,Leu5]enkephalinyl-Arg, by human blood plasma and serum enzymes was investigated. The degradation products were identified. Based on the kinetic data, the principal pathways of degradation and its limiting steps were established.
authors: O A
authors: OA
authors: Mirgorodskaia
authors: A V
authors: AV
authors: Podtelezhnikov
authors: A A
authors: AA
authors: Shevchenko
mesh_terms: D001920:Bradykinin / Q000097:blood*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004745:Enkephalins / Q000097:blood*; D006801:Humans; D007700:Kinetics; D013058:Mass Spectrometry / Q000379:methods
chemical_list: D004745:Enkephalins; D001920:Bradykinin
vernacular_title: Izuchenie degradatsii peptidov v plazme i syvorotke krove cheloveka metodom vysokoéffektivnoĭ zhidkostnoĭ khromatografii-mass- spektrometrii ERIAD.