title: Antibodies in serum of patients with Alzheimer's disease cause immunolysis of cholinergic nerve terminals from the rat cerebral cortex.
abstract: A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.
authors: Department of Biochemistry, Imperial College of Science and Technology, London, UK.
authors: H F
authors: HF
authors: Bradford
authors: P
authors: P
authors: Foley
authors: M
authors: M
authors: Docherty
authors: H
authors: H
authors: Fillit
authors: V N
authors: VN
authors: Luine
authors: B
authors: B
authors: McEwen
authors: G
authors: G
authors: Bucht
authors: B
authors: B
authors: Winbald
authors: J
authors: J
authors: Hardy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000276:immunology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002799:Cholinergic Fibers / Q000201:enzymology / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000906:Antibodies; D002795:Choline O-Acetyltransferase