title: [Lymphocyte subpopulations in patients with viral hepatitis B and delta-infections].
abstract: Changes in subpopulations of T3, T4, T8, HNK-1, Ia-positive, B-IgM and B-IgG producing lymphocytes were studied in patients with acute and chronic active virus hepatitis B and delta infection. A decrease of T4-helpers/inducers was demonstrated in all the groups under study and of T3-lymphocytes only in patients with delta-hepatitis turning into liver cirrhosis. The number of suppressors/cytotoxic T8 cells increased and T4/T8 ratio decreased in most patients. The number of HNK-1, Ia-positive, B-IgM and B-IgG lymphocytes increased in many subjects examined. Most marked quantitative changes in lymphocyte subpopulations were observed in patients with severe forms of delta-hepatitis and with liver cirrhosis. Changes in lymphocyte subpopulations in patients with viral hepatitis B and delta-infection are explained by reconstruction of the immune system in response to infection, affection of lymphocytes with viruses and emergence of antilymphocyte antibodies.
authors: G I
authors: GI
authors: Savitskiĭ
authors: N N
authors: NN
authors: Zhilina
authors: K V
authors: KV
authors: Morgunov
authors: N P
authors: NP
authors: Bugaeva
authors: I N
authors: IN
authors: Khlopova
mesh_terms: D000956:Antigens, Viral / Q000032:analysis; D002908:Chronic Disease; D006509:Hepatitis B / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D003699:Hepatitis D / Q000276:immunology*; D006801:Humans; D007958:Leukocyte Count; D008103:Liver Cirrhosis / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D006514:Hepatitis B Surface Antigens
vernacular_title: Subpopuliatsii limfotsitov u bol'nykh virusnym gepatitom B i del'ta-infektsieĭ.