Calvarial bone regeneration using osteogenin.
This experimental study reports on the application of a partially purified noncollagenous protein extracted from cortical bone to restore craniotomy defects in Papio species (baboon). The partially purified protein (osteogenin) produced significantly more bone formation in calvarial wounds than was found in the untreated controls. There were no adverse tissue reactions from the implanted xenogeneic osteogenin.
Hollinger
J
J
Walter Reed Army Medical Center, Washington, DC 20307-5300.
Mark
D E
DE
Bach
D E
DE
Reddi
A H
AH
Seyfer
A E
AE
D000818:Animals; D001857:Bone Matrix; D001861:Bone Regeneration / Q000187:drug effects*; D002214:Capsules; D005260:Female; D006133:Growth Substances / Q000494:pharmacology*; D008297:Male; D010215:Papio; D012886:Skull / Q000187:drug effects / Q000378:metabolism*
D002214:Capsules; D006133:Growth Substances