[In vitro action spectrum of a new antifungal agent derived from morpholine: amorolfin].
The minimal inhibitory concentrations of amorolfin against yeasts, dermatophytes, Sporothrix schenckii and moduls were determined on Sabouraud's dextrose agar by dilution test procedure (Dixon's agar for Malassezia). The yeasts (Candida, Torulopsis, Trichosporon) present various susceptibility, MIC ranged from 0.01 to 1 micrograms/ml-1 for sensible strains particularly Malassezia (0.005-0.5 microgram/ml-1) ranged from 20 to 100 micrograms/ml-1 for resistant isolates. Amorolfine is also effective on Sporothrix schenckii (0.5 microgram/ml-1) Scopulariopsis brevicaulis (0.2-5 micrograms/ml-1) but with Aspergillus and Fusarium higher concentrations (10-100 micrograms/ml-1) are necessary. Dermatophytes are largely susceptible to amorolfine (MIC ranged to 0.005 to 0.2 microgram/ml-1) whatever the tested species were belonging to Microsporum, Trichophyton or Epidermophyton. So, amorolfine seems to be a very effective antifungal agent against those pathogenic fungi.
Regli
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Laboratoire de Botanique et Cryptogamie, Faculté de Pharmacie, Marseille.
Ferrari
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H
D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D001230:Aspergillus / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009025:Morpholines / Q000494:pharmacology*; D015003:Yeasts / Q000187:drug effects*
D000935:Antifungal Agents; D009025:Morpholines; C038974:amorolfine
Spectre d'action in vitro d'un nouvel antifongique dérivé de la morpholine: l'amorolfine.