[Effect of the diethylamide of nicotinic acid (cordiamine) on the hydroxylating function of the liver].
Diethylamide of nicotinic acid (subcutaneously, 40 and 120 mg/kg, once a day for 4 days) was shown to exert no influence on p-hydroxylation of aniline and to increase the rate of N-demethylation of amidopyrine and ethylmorphine in the rat liver microsomal fraction by 21 and 47% as compared with the control. At the same dose of 40 mg/kg and the same schedule of administration the drug was found to increase urine excretion of antipyrine metabolites: nor-antipyrine, 4-hydroxy-antipyrine and the sum of metabolites by 229, 89 and 80%, respectively, during the first 90 min of the experiment. Excretion of antipyrine, 3-hydroxymethyl-antipyrine and 3-carboxymethyl-antipyrine underwent no significant changes. The duration of hexobarbital-induced sleep of the rats was shown to be decreased by 26%.
Bushma
M I
MI
Zavodnik
L B
LB
Lukienko
P I
PI
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D000983:Antipyrine / Q000652:urine; D005036:Ethylmorphine / Q000378:metabolism; D006591:Hexobarbital / Q000037:antagonists & inhibitors; D006900:Hydroxylation; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009552:Nikethamide / Q000494:pharmacology*; D051381:Rats
D000814:Aniline Compounds; D000632:Aminopyrine; D009552:Nikethamide; D006591:Hexobarbital; D006899:Mixed Function Oxygenases; D005036:Ethylmorphine; C023650:aniline; D000983:Antipyrine
K voprosu o vliianii diétilamida nikotinovoĭ kisloty (kordiamina) na gidroksiliruiushchuiu funktsiiu pecheni.