title: Evaluation of chromosomal aberrations in bone marrow of 1C3F1 mice.
abstract: The chemical caprolactam (CAP) was tested for induction of chromosomal aberrations in bone marrow of male and female 1C3F1 mice at a single dose of 1000 mg/kg by oral intubation of an aqueous solution at a volume of 0.1 ml/10 g of body weight. Bone marrow was sampled from groups of 10 animals 24, 30 and 48 h after treatment. CAP did not produce chromosomal aberrations under the present experimental conditions. At the same time, benzo[a]pyrene, used as a positive control, significantly increased the aberration rates at a dose of 63 mg/kg.
authors: GSF-Institut für Säugetiergenetik, Neuherberg, F.R.G.
authors: I D
authors: ID
authors: Adler
authors: I
authors: I
authors: Ingwersen
mesh_terms: D000818:Animals; D001381:Azepines / Q000633:toxicity*; D001564:Benzo(a)pyrene / Q000633:toxicity; D001853:Bone Marrow / Q000187:drug effects*; D002209:Caprolactam / Q000633:toxicity*; D002869:Chromosome Aberrations; D005260:Female; D008297:Male; D051379:Mice; D009153:Mutagens
chemical_list: D001381:Azepines; D009153:Mutagens; D001564:Benzo(a)pyrene; D002209:Caprolactam