Neuroleptic malignant syndrome: a case report with post-mortem brain and muscle pathology.
The neuroleptic malignant syndrome is a rare but dangerous complication of treatment with neuroleptics. The aetiology and pathophysiology of the syndrome are reviewed, and a fatal case is presented where both brain and muscle pathology are described. Striking myopathic changes in this case, accompanied by only minimal and non-specific brain abnormalities, support a peripheral rather than central mechanism for the hyperthermia.
Jones
E M
EM
University of Bristol, UK.
Dawson
A
A
D000368:Aged; D001921:Brain / Q000473:pathology*; D002545:Brain Ischemia / Q000473:pathology; D002746:Chlorpromazine / Q000008:administration & dosage / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007520:Isocarboxazid / Q000008:administration & dosage / Q000009:adverse effects*; D009132:Muscles / Q000473:pathology*; D009459:Neuroleptic Malignant Syndrome / Q000473:pathology*; D013345:Subarachnoid Hemorrhage / Q000473:pathology
D007520:Isocarboxazid; D002746:Chlorpromazine