[The therapeutic efficacy of phonophoresis of ribonucleic acid hydrolysate in toxic retinal lesions].
Experiments on 82 rabbits (162 eyes) have shown that RNA hydrolysate phonophoresis possesses a pronounced protective action by stimulating a rapid cupping of metabolic disturbances and a restoration of the chemical state of cellular elements of the retina in a relatively remote terms after the introducing of a monobromoacetate inhibitor (within first 3 days). Experimental therapy beginning 10 days after the introducing of monobromoacetate, i. e. in the period when, besides metabolic disturbances histomorphologic changes were also seen, considerably stimulated activation of compensatory-inflammatory processes. The investigations carried out allow to recommend RNA hydrolysate phonophoresis for clinical examination in dystrophic diseases of the retina.
Plevinskis
V P
VP
Skrinnik
A S
AS
Fuks
B B
BB
Bormusova
E A
EA
Konovalova
N V
NV
D000085:Acetates / Q000506:poisoning; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D006651:Histocytochemistry; D008297:Male; D009843:Oligoribonucleotides; D015612:Phonophoresis; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000378:metabolism; D012162:Retinal Degeneration / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D012265:Ribonucleotides / Q000008:administration & dosage*; D013997:Time Factors
D000085:Acetates; D009843:Oligoribonucleotides; D012265:Ribonucleotides; C031373:ENKAD; C016274:bromoacetate
Izuchenie terapevticheskoĭ éffektivnosti fonoforeza gidrolizata ribonukleinovoĭ kisloty pri toksicheskikh porazhennykh setchatki.