Novel antitumor antibiotic phospholine. 1. Production, isolation and characterization.
Phospholine was isolated as an antitumor antibiotic from the fermentation broth of Streptomyces hygroscopicus. Phospholine is an amphoteric compound which has an amino group and a phosphoric acid ester as functional groups. Phospholine shows strong activities against L1210, P388 and EL-4.
Ozasa
T
T
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
Suzuki
K
K
Sasamata
M
M
Tanaka
K
K
Kobori
M
M
Kadota
S
S
Nagai
K
K
Saito
T
T
Watanabe
S
S
Iwanami
M
M
D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D007783:Lactones / Q000302:isolation & purification / Q000627:therapeutic use; D007942:Leukemia, Experimental / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D009943:Organophosphorus Compounds / Q000302:isolation & purification / Q000627:therapeutic use; D013302:Streptomyces
D000903:Antibiotics, Antineoplastic; D007783:Lactones; D009943:Organophosphorus Compounds; C061212:phospholine