[Effects of synthetic new drug SC1001-sodium on respiratory frequency, heart rate, rectal temperature and electrocorticogram in rabbits].
Seventeen normal male rabbits weighing 1.7-2.8 kg were randomly divided into 2 groups. The experimental group (ten rabbits) was injected with SC1001Na (200 mg/kg, i.p.). The control group (seven rabbits) was injected with normal saline of the same volume. Continuous observations for 6 hours were made after injection, with reference to respiratory frequency (RF), heart rate (HR), rectal temperature (RT) and ECoG of these rabbits. The results of experiments indicate that SC1001Na has a slight inhibitory effect on RF and RT, an obvious inhibitory effect on the activity of central nervous system, and an accelerating effect on HR in rabbits.
Chen
Q X
QX
Chai
H X
HX
Xie
Y G
YG
Xu
J G
JG
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002934:Cinnamates / Q000494:pharmacology*; D004569:Electroencephalography; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D012007:Rectum; D012119:Respiration / Q000187:drug effects*
D002934:Cinnamates; C058003:SC 1001A