title: [The effect of modification of excipients for the bioavailability of vinburnine].
abstract: Biopharmaceutic comparison is achieved between commercialized capsules of vinburnine and a new dosage form. The difference between the two drug products concerns only the quality of excipients. Drug bioavailability decreases of about 10%, in despite of the very important, and well known, interindividual variations of vincamine drug products. Only the absorption rate seems statistically lightly decreased by the new formulation.
authors: P A
authors: PA
authors: Sado
authors: D
authors: D
authors: Gibassier
authors: R
authors: R
authors: Leverge
mesh_terms: D000328:Adult; D001682:Biological Availability; D005079:Excipients; D005260:Female; D006801:Humans; D008297:Male; D014748:Vinca Alkaloids / Q000493:pharmacokinetics*
chemical_list: D005079:Excipients; D014748:Vinca Alkaloids; C016422:eburnamonine
vernacular_title: Influence d'une modification d'excipients sur la biodisponibilité de la vinburnine.