Effects of thiobenzamide on the rat immune system.
Thiobenzamide (TB) is a thiono-containing compound endowed with liver-damaging properties and promoting ability on liver carcinogenesis. When administered in a single dose to normal as well as to adrenalectomized rats, this compound induced a striking thymus cortex involution without relevant effects on the morphological features of other lymphoid organs such as spleen and lymph nodes. The proximal TB metabolite TB-S-oxide (TBSO) shared these effects with the parent compound, whereas the terminal metabolite benzamide (BA) was ineffective. The effect of TB on thymus was found to be dose- and age-dependent. Furthermore, acute TB treatment 12h before priming with the T-dependent antigen sheep erythrocytes impaired the secondary antibody response. In addition, TB administration affected not only cell-mediated immunity (as evidenced by a decreased delayed hypersensitivity response) but also mitogen-induced proliferation of blood lymphocytes. On the contrary, the chemotactic response of polymorphonuclear leukocytes obtained from TB-treated rats was unchanged.
Pasquinelli
P
P
Institute of General Pathology, University of Pisa, Italy.
Vaglini
F
F
Pieracci
D
D
Ettorre
V
V
Puccini
M
M
Malvaldi
G
G
D000367:Age Factors; D000577:Amides / Q000494:pharmacology*; D000818:Animals; D000995:Antitubercular Agents / Q000378:metabolism / Q000494:pharmacology*; D001549:Benzamides / Q000378:metabolism / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007107:Immune System / Q000187:drug effects*; D008099:Liver / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013854:Thioamides / Q000378:metabolism / Q000494:pharmacology*; D013950:Thymus Gland / Q000187:drug effects / Q000502:physiology
D000577:Amides; D000995:Antitubercular Agents; D001549:Benzamides; D013854:Thioamides; C015539:thiobenzamide