title: [Refractory depression: therapeutic alternatives].
abstract: A group of 89 patients admitted to the Psychiatric Unit of a General Hospital, with diagnosis of depression according to ICD-9 criteria and randomly chosen were studied. 26 of them (29.2%) were resistant depressions and 63 (7.82%) responded to treatment. Both groups were composed retrospectively in order to analyse resistance or lack of response to a first treatment with tricyclic or tetracyclic antidepressants in effective dosages. We considered: the personality type; the associated somatic pathology; prolonged social stress; period of evolution of the disorder; previous treatments; type of disorder uni or bipolar; familial morbidity; diagnosis reconsideration; analysis of therapeutic compliance; side effects and intolerance. We observed a statistically significant difference with regard to prophylactic treatment (38.4% resistant versus 98.3% non-resistant, p less than 0.0001); a greater suspicion of psycho-organicity in the resistant group (p less than 0.05); a longer interval of time for the resistant group between the beginning of the disorder and the beginning of treatment in our service (F: 1.45, t: 2.58, p less than 0.01). The alternatives used with our patients are analysed and we propose schedules for tackling this kind of problem.
authors: J J
authors: JJ
authors: López-Ibor Aliño
authors: A
authors: A
authors: Chinchilla
authors: M
authors: M
authors: Vega
authors: P
authors: P
authors: Sánchez
authors: M
authors: M
authors: Camarero
authors: L
authors: L
authors: Jordá
authors: R
authors: R
authors: Viñas
authors: I
authors: I
authors: Moreno
mesh_terms: D000928:Antidepressive Agents / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D011897:Random Allocation; D012189:Retrospective Studies; D012959:Socioeconomic Factors
chemical_list: D000928:Antidepressive Agents
vernacular_title: Depresiones resistentes: alternativas terapéuticas.