[The cutaneous bioavailability of alpha-chymotrypsin from ointments].
In view of improving the cutaneous bioavailability of alpha-chymotrypsin from ointments, the stability of this enzyme in two hydrophile ointment bases, macrogoli and carbopol, was tested. The cutaneous bioavailability of alpha-chymotrypsin in ointments, estimated by determining the anti-inflammatory action, underlines the important role played both by the ointment base and by the enzyme activating substances. By correlating the determinations of alpha-chymotrypsin enzymatic activity with the anti-inflammatory action a correlation between the manifested activity and the active substance stability was noticed.
Gafiţanu
E
E
Filip
M
M
Mungiu
O C
OC
Nicolaiciuc
C
C
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001682:Biological Availability; D002918:Chymotrypsin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy; D008297:Male; D009823:Ointment Bases / Q000493:pharmacokinetics; D009824:Ointments; D051381:Rats; D012869:Skin Absorption / Q000187:drug effects*; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009823:Ointment Bases; D009824:Ointments; D002918:Chymotrypsin
Cercetări privind biodisponibilitatea cutanată a alfa-chimotripsinei din unguente.