[Is Stewart's malignant midline granuloma a peripheral T-cell lymphoma? Apropos of 5 cases].
Midline granuloma includes diverse clinicopathological entities, such as Wegener granulomatosis, polymorphic reticulosis, lethal midline granuloma and conventional malignant lymphoma of the nose usually of B-cell origin. The authors describe five patients with LMG clinically and pathologically typical. Using an extensive panel of monoclonal antibodies, they demonstrate an "activate" T-cell phenotype observed on the initial lesion of the face in one patient, similar to that found in two patients with LMG but studied after dissemination in peripheral T-cell lymphoma. Furthermore, many atypical cells were found in LMG, and stained with the Ki-67 monoclonal antibody, a marker of proliferating cells. These findings support the view that LMG is closely related to T-cell malignancies. Two of them were treated with recombinant Interferon alpha 2a followed by a response rapidly objective. Immunohistologic studies are very important for confirming the T-cell origin of such a disease and for selecting patients to be treated with Interferon alpha.
Dubois
A
A
Rossi
J F
JF
Double
C M
CM
Pignodel
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C
Roumieux
J L
JL
Lafontaine
J S
JS
Lallemant
J G
JG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006103:Granuloma, Lethal Midline / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D007150:Immunohistochemistry; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D008223:Lymphoma / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D011994:Recombinant Proteins; D013601:T-Lymphocytes
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins
Le granulome malin centro-facial de Stewart est-il un lymphome T périphérique? A propos de 5 observations.