Interleukin 1 stimulates production of LTC4 and other eicosanoids by macrophages.
Human recombinant IL-1 alpha stimulates in a dose-dependent fashion the production of 5-lipoxygenase-derived LTC4 and, to a lesser extent, of cyclooxygenase-derived eicosanoids (PGE2, 6-keto PGF1 alpha, TXB2) by murine resident peritoneal macrophages. Enhancement of eicosanoid production was evident on unstimulated macrophages, but only marginal on macrophages phagocytosing zymosan. The effect of IL-1 was similarly achieved at physiological (37 degrees C) as well as at higher (39 degrees C) temperatures. Human recombinant IL-1 beta, human natural IL-1, and partially purified murine IL-1-rich supernatant also stimulated eicosanoid production by macrophages, although IL-1 alpha appeared to be the most effective.
Censini
S
S
Laboratory of Immunopharmacology, Sclavo Research Center, Siena, Italy.
Bartalini
M
M
Tagliabue
A
A
Boraschi
D
D
D000818:Animals; D002455:Cell Division; D007375:Interleukin-1 / Q000494:pharmacology*; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D011453:Prostaglandins / Q000096:biosynthesis*; D011863:Radioimmunoassay; D011994:Recombinant Proteins / Q000494:pharmacology; D013189:SRS-A / Q000096:biosynthesis*; D013929:Thromboxane B2 / Q000096:biosynthesis*; D013950:Thymus Gland / Q000166:cytology
D007375:Interleukin-1; D011453:Prostaglandins; D011994:Recombinant Proteins; D013189:SRS-A; D013929:Thromboxane B2