title: Meropenem: evidence of lack of proconvulsive tendency in mice.
abstract: The proconvulsive tendency of the novel carbapenem, meropenem was compared to that of imipenem, alone and in combination with cilastatin. The potentiation of metrazole-induced convulsions in mice was measured. Both imipenem and imipenem/cilastatin caused significant potentiation of metrazole-induced convulsions at a dose of 200 mg/kg, i.v. In contrast, meropenem (50-400 mg/kg, iv) failed to exhibit any significant potentiation of metrazole-induced seizures.
authors: ICI Pharmaceuticals Group, ICI Americas Inc., Wilmington, DE 19897.
authors: J B
authors: JB
authors: Patel
authors: R E
authors: RE
authors: Giles
mesh_terms: D000818:Animals; D015780:Carbapenems / Q000633:toxicity*; D015377:Cilastatin / Q000633:toxicity; D015378:Imipenem / Q000633:toxicity; D008297:Male; D000077731:Meropenem; D051379:Mice; D012640:Seizures / Q000139:chemically induced*; D013845:Thienamycins / Q000633:toxicity*
chemical_list: D015780:Carbapenems; D013845:Thienamycins; D015377:Cilastatin; D015378:Imipenem; D000077731:Meropenem