Parental origin of chromosomal nondisjunction in a 49,XXXXY male using recombinant-DNA techniques.
We have analyzed the origin, in a patient with 49,XXXXY, of the four X-chromosomes by means of recombinant DNA techniques. We found a maternal origin of the four X-chromosomes due to non-disjunctions in the first and second meiotic divisions.
Villamar
M
M
Departamento de Genética, Fundación Jiménez Diaz, Madrid, Spain.
Benitez
J
J
Fernández
E
E
Ayuso
C
C
Ramos
C
C
D002675:Child, Preschool; D015342:DNA Probes; D004274:DNA, Recombinant; D005147:Facial Bones / Q000002:abnormalities; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008540:Meiosis; D009035:Mothers; D009630:Nondisjunction, Genetic; D011123:Polyploidy; D011596:Psychomotor Disorders / Q000235:genetics; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D012886:Skull / Q000002:abnormalities; D014960:X Chromosome
D015342:DNA Probes; D004274:DNA, Recombinant