Prevention of anaphylactoid shock in the rat by the calmodulin antagonist thioridazine.
Calmodulin antagonists, which block intracellular calcium/calmodulin-dependent processes like exocytosis, inhibit effectively mast cell mediator release in vitro. Our experiments confirm that they are also effective in vivo. Thioridazine (5 mg/kg), a representative of the group, prevents the severe anaphylactoid shock in the rat, induced with compound 48/80, and permits a rapid and complete recovery, with special protection of respiration. Thus, calmodulin antagonists seem to be potential drugs for the management of mast cell-mediated allergic diseases.
Grollmuss
O
O
Department of Pharmacology, University of Ulm, FRG.
Sanchez-Delgado
E
E
Bader
H
H
D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D003490:Cyanosis / Q000517:prevention & control; D006339:Heart Rate / Q000187:drug effects; D006940:Hyperemia / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D013881:Thioridazine / Q000627:therapeutic use*; D014554:Urination / Q000187:drug effects; D003189:p-Methoxy-N-methylphenethylamine
D002147:Calmodulin; D003189:p-Methoxy-N-methylphenethylamine; D013881:Thioridazine