Synthesis of a di- and a tri-saccharide related to the K-antigen of Klebsiella type 10 and a study of their inhibition in the precipitin reaction.
Syntheses of methyl 3-O-alpha-D-galactopyranosyl-alpha-D-mannopyranoside (10) and methyl 3-O-alpha-D-galactopyranosyl-2-O-(beta-D-glucopyranosyluronic acid)-alpha-D-mannopyranoside (11) in good yield are described. Both 10 and 11 significantly inhibit antigen-antibody precipitation in the Klebsiella Type 10 immune system. The results provide more evidence for the structure (1) of the antigen from Klebsiella K-10 and its immunodominant grouping.
Sarkar
A K
AK
Department of Biological Chemistry, Indian Association for the Cultivation of Science, Calcutta.
Ray
A K
AK
Roy
N
N
D000942:Antigens, Bacterial / Q000276:immunology*; D002240:Carbohydrate Sequence; D004187:Disaccharides / Q000138:chemical synthesis* / Q000276:immunology; D007709:Klebsiella / Q000276:immunology*; D008969:Molecular Sequence Data; D011233:Precipitin Tests; D014312:Trisaccharides / Q000138:chemical synthesis* / Q000276:immunology
D000942:Antigens, Bacterial; D004187:Disaccharides; D014312:Trisaccharides; C061535:methyl 3-O-galactopyranosyl-2-O-(glucopyranosyluronic acid)mannopyranoside; C061534:methyl 3-O-galactopyranosylmannopyranoside