Effect of cocarboxylase in dogs subjected to experimental septic shock.
We examined the effects of cocarboxylase treatment on both the hemodynamic variables and metabolic function during endotoxic shock in dogs. Cocarboxylase inhibited deterioration in metabolic function as reflected by improved pH and base excess as well as maintenance of normal oxygen consumption. Significant improvements in mean arterial pressure and cardiac index were also seen. Cocarboxylase is a major coenzyme of mitochondrial pyruvate dehydrogenase and may exert its beneficial effects via this complex.
Lindenbaum
G A
GA
Department of Surgery and Cardiothoracic Surgery, Medical Center, Philadelphia, PA 19141.
Larrieu
A J
AJ
Carroll
S F
SF
Kapusnick
R A
RA
D000818:Animals; D001784:Blood Gas Analysis; D004285:Dogs; D004731:Endotoxins / Q000008:administration & dosage; D006439:Hemodynamics / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D010101:Oxygen Consumption / Q000187:drug effects; D012772:Shock, Septic / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D013835:Thiamine Pyrophosphate / Q000627:therapeutic use*; D013997:Time Factors
D004731:Endotoxins; D013835:Thiamine Pyrophosphate