[Hepatoprotective activity of analogs of cinnamic acid].
The hepatoprotective activity of 16 derivatives of +hydroxycinnamic acids was studied on the model of acute tetrachloromethane-induced hepatitis. The effects of the agents administered in doses of 5, 15, and 30 mg/kg were compared with those of silibor, vitamin E and flamine. The studied compounds were shown to possess the bile-expelling, antioxidant and membrane-protective effects being superior in some cases to similar effects of reference drugs. The structure-activity relationship was established.
Sal'nikova
S I
SI
Dorogovoz
S M
SM
Slyshkov
V V
VV
Guzhva
N N
NN
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D002756:Cholagogues and Choleretics / Q000494:pharmacology; D002934:Cinnamates / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D002756:Cholagogues and Choleretics; D002934:Cinnamates; D010936:Plant Extracts; C015886:Flamin; D014810:Vitamin E
Gepatozashchitnaia aktivnost' analogov korichnoĭ kisloty.