Evaluation of chromosomal aberrations in bone marrow of 1C3F1 mice.
The chemical caprolactam (CAP) was tested for induction of chromosomal aberrations in bone marrow of male and female 1C3F1 mice at a single dose of 1000 mg/kg by oral intubation of an aqueous solution at a volume of 0.1 ml/10 g of body weight. Bone marrow was sampled from groups of 10 animals 24, 30 and 48 h after treatment. CAP did not produce chromosomal aberrations under the present experimental conditions. At the same time, benzo[a]pyrene, used as a positive control, significantly increased the aberration rates at a dose of 63 mg/kg.
Adler
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GSF-Institut für Säugetiergenetik, Neuherberg, F.R.G.
Ingwersen
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D000818:Animals; D001381:Azepines / Q000633:toxicity*; D001564:Benzo(a)pyrene / Q000633:toxicity; D001853:Bone Marrow / Q000187:drug effects*; D002209:Caprolactam / Q000633:toxicity*; D002869:Chromosome Aberrations; D005260:Female; D008297:Male; D051379:Mice; D009153:Mutagens
D001381:Azepines; D009153:Mutagens; D001564:Benzo(a)pyrene; D002209:Caprolactam