The effects of intracerebroventricularly administered angiotensin II on blood pressure and cochlear blood flow in rats and guinea pigs.
Guinea pigs and Sprague-Dawley rats were intracerebroventricularly (icv) infused with various doses of angiotensin II (AII) in order to investigate central control of and species differences in cochlear blood flow (CBF) and blood pressure (BP). The results indicated a positive dose-response relationship between icv infusions of AII for BP and CBF in members of both species. This relationship was more predictable in the guinea pig than in the rat. In addition, responses to similar AII doses between species indicated that: a) BP elevations were significantly greater in the rat than in the guinea pig, b) CBF elevations were not significantly different between the rats and guinea pigs, and c) CBF was more highly correlated with BP in the guinea pig than in the rat. These results suggest that different relationships may exist between BP and CBF in rats and guinea pigs.
Flynn
A J
AJ
Department of Psychology, Washington State University, Pullman 99164-4830.
Quirk
W S
WS
Dengerink
H A
HA
Wright
J W
JW
D000804:Angiotensin II / Q000008:administration & dosage*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003051:Cochlea / Q000098:blood supply* / Q000187:drug effects; D006168:Guinea Pigs; D007276:Injections, Intraventricular; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects
D000804:Angiotensin II