In-vitro evaluation of antibiotic combinations against Campylobacter fetus.
We evaluated the in-vitro activity of 16 antibiotics against 22 clinical isolates of Campylobacter fetus. The interaction of these antibiotics was also tested by chequer-board titration and time-kill assay. Eight antibiotic combinations were evaluated. Antagonism was not found with any of the combinations tested. The highest synergistic effect was obtained with a combination of ampicillin and cefazolin or ampicillin and gentamicin.
Goossens
H
H
WHO Collaborating Centre for Enteric Campylobacter, St Pieters University Hospital, Brussels, Belgium.
Coignau
H
H
Vlaes
L
L
Butzler
J P
JP
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001769:Blood / Q000382:microbiology; D002169:Campylobacter Infections / Q000188:drug therapy / Q000382:microbiology; D002168:Campylobacter fetus / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D004338:Drug Combinations; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D006801:Humans; D007700:Kinetics; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D004338:Drug Combinations