Magnetic resonance studies on the development of ischemic edema in an early period after occlusion of middle cerebral artery in a rat.
The development of ischemic edema after middle cerebral artery occlusion in a rat was studied using T1 and T2-weighted magnetic resonance imaging (MRI). Examinations were performed with Helmholtz coil and multiple echo sequences with TR 1,500 ms and TE 30-240 ms (8 echoes) were used. T2 prolongation was noted already 3 hours after experimental stroke and the values increased during the time of the study. T1-weighted images were much less sensitive for the detection of increased water content. This experiment forms a basis for MR studies on the formation and resolution of cerebral edema and can be useful for studies on efficacy of different medical measures against ischemic edema.
Kotwica
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Z
Thuomas
K A
KA
Persson
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D000818:Animals; D001929:Brain Edema / Q000175:diagnosis* / Q000209:etiology; D002545:Brain Ischemia / Q000175:diagnosis* / Q000209:etiology; D002561:Cerebrovascular Disorders / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains