[Side-effects of the clonidine test in 20 children with short stature].
A single oral dose of 0.15 mg/m2 of clonidine was given to twenty children and adolescents (range 1.6 to 17.4 years) with short stature (height standard deviation score -3.3 +/- 1.1). In 18 (90%) tests the plasma growth hormone response was positive (13.5 +/- 7 ng/ml) without false-negatives. 16 (80%) were drowsy, lasting for 3-4 hours. The systolic blood pressure decreased from 99.6 +/- 13 mmHg (basal) to 81 +/- 13.9 and 85.8 +/- 11.8 (p less than 0.05), after 180 and 240 minutes of clonidine administration. The cardiac frequency decreased from 92 +/- 18 to 74 +/- 14 beat/minute (p less than 0.05). A positive linear correlation (p less than 0.05) was found between peak serum growth hormone concentration and peak systolic hypotension (r = 0.707). The great sensitivity of the clonidine test is confirmed. The side-effects observed suggest that it is necessary to control blood pressure during the 5 hours following the oral administration of clonidine.
Durá Trave
T
T
Hospital Provincial, Facultad de Medicina, Departamento de Pediatría, Universidad de Alicante.
Moya Benavent
M
M
Buades Esplá
A
A
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003000:Clonidine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006130:Growth Disorders / Q000097:blood / Q000503:physiopathology*; D013006:Growth Hormone / Q000097:blood*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007223:Infant; D008297:Male
D013006:Growth Hormone; D003000:Clonidine
Efectos colaterales del test de clonidina aplicado a 20 niños con talla corta.