[Chronic myelogenous leukemia maintained in remission by interferon alpha presenting with bladder cancer].
We present a case of a 63-year-old man who was diagnosed CML at the onset of bladder transitional carcinoma. He had been treated with subcutaneous injection of natural interferon-alpha at the dose of 2 X 10(6) U on consecutive days. Four weeks later, he achieved remission and then received curative operation. Ph1 chromosome transiently decreased to 40%. For more than 16 months, he remained in remission. Since in CML Ph1 clone can be found in B cells and CML itself may result in hypogammaglobulinemia which may be basis of carcinogenesis, it was speculated that hypogammaglobulinemia found in this case related to carcinogenesis.
Kobayashi
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Ogawa
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D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D011300:Preoperative Care; D012074:Remission Induction; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000601:surgery
D007370:Interferon Type I