title: [Comparative studies of cyclic 11, 12 erythromycin carbonate (davercin) and erythromycin a levels in lung tissue, serum and bronchial secretions].
abstract: A comparison of serum, pulmonary tissue and bronchial secretory levels of erythromycin and cyclic--11,12 carbonate of erythromycin (Davercin--Polfa) was carried out in 55 patients with lung cancer. All patients received erythromycin and Davercin 80 hours prior surgery, during which a small fragment of pulmonary tissue was removed for further evaluation. Concentration of both antibiotics was determined microbiologically. Better penetration of Davercin to the pulmonary tissue was found, as well as higher tissue concentration. The study demonstrates the advantage of Davercin over erythromycin in treating bacterial infections of the respiratory system.
authors: P
authors: P
authors: Krakówka
authors: A
authors: A
authors: Kazimierczak
authors: J
authors: J
authors: Kuś
authors: J
authors: J
authors: Zagdańska
authors: A
authors: A
authors: Schaeffer
authors: K
authors: K
authors: Bireta
authors: H
authors: H
authors: Zdziarska
authors: H
authors: H
authors: Olechnowicz
authors: E
authors: E
authors: Sawicka
authors: P
authors: P
authors: Kołb
mesh_terms: D001826:Body Fluids / Q000032:analysis; D004917:Erythromycin / Q000032:analysis* / Q000493:pharmacokinetics / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D008168:Lung / Q000032:analysis* / Q000378:metabolism; D008297:Male
chemical_list: C029784:erythromycin A cyclic 11,12-carbonate; D004917:Erythromycin
vernacular_title: Badania porównawcze stezenia cyklicznego 11, 12 weglanu erytromycyny a (davercin) i erytromycyny a w tkance płucnej, surowicy krwi i śluzie oskrzelowym.