[The discordance between the presence of identifiable p24 antigen in the blood and the isolation of HIV from the blood is not influenced by methodological factors].
To clarify the biological, clinical and prognostic relevance of HIV isolation from plasma and explain the relation to p24 antigenemia, we studied these two markers in 67 anti-HIV positive subjects in different stages of the disease. The results suggest that discordances between these two parameters are not dependent on methodological problems and may be attributed to yet unexplained biological phenomena. Some hypotheses to explain the observed discrepancies are suggested.
Fiore
J R
JR
Casalino
C
C
Fico
C
C
Monno
L
L
Esposito
M
M
Angarano
G
G
Pastore
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000276:immunology* / Q000382:microbiology; D015415:Biomarkers / Q000032:analysis*; D015488:HIV Antigens / Q000032:analysis*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans
D015415:Biomarkers; D015488:HIV Antigens
La discordanza tra presenza di antigenemia p24 dosabile e isolamento dell'HIV dal plasma non è influenzata da fattori di ordine metodologico.