Cardiovascular effects of increasing sodium chloride concentrations microinjected into the nucleus tractus solitarii of the rat.
Unilateral microinjection of increasing sodium chloride concentrations (154.0-256.6 mM) into the nucleus tractus solitarii (NTS) of urethane-anesthetized rats evoked hypotension and bradycardia. The effect was elicited only in a restricted area of the mediocaudal NTS. Microinjection of demineralized water, an isotonic sucrose solution and artificial cerebrospinal fluid were without effect. The possible existence of sodium-sensitive neurons in the NTS is discussed.
Lukovic
L
L
Institute of Experimental Pharmacology, Centre of Physiological Sciences, Bratislava, Czechoslovakia.
de Jong
W
W
de Wied
D
D
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D008845:Microinjections; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology*; D013997:Time Factors
D012965:Sodium Chloride