Comparison of endothelial damage produced by control and surface modified poly(methyl methacrylate) intraocular lenses.
Biological studies were performed on control and surface modified (passivated) poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs). In acute corneal touch studies in cats, surface modified IOLs caused little endothelial damage and only single cells or small debris were seen adhering to the IOL. In contrast, control IOLs caused major endothelial damage and large sheets of endothelial cells were seen adhering to the control IOL surface. Use of the surface modified IOLs may help reduce the associated endothelial damage during cataract surgery.
Balyeat
H D
HD
Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City 73104.
Nordquist
R E
RE
Lerner
M P
MP
Gupta
A
A
D000818:Animals; D002415:Cats; D004728:Endothelium, Corneal / Q000473:pathology* / Q000648:ultrastructure; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008768:Methylmethacrylates; D008855:Microscopy, Electron, Scanning; D013501:Surface-Active Agents
D008768:Methylmethacrylates; D013501:Surface-Active Agents