[Degree of proliferative response to concanavalin A of spleen cells of mice of different strains and production of interleukin-2].
Differences in the lymphoproliferative response to Con A of spleen cells allowed one to distinguish a high responder (BALB/c and DBA/2) and low responder (C57BL/6 and CC57BR) mice. BALB/c and DBA/2 mice (H-2d haplotype) produced interleukin 2 better, than C57BL/6 and CC57BR mice (H-2b haplotype). However acceptance of interleukin 2 was better in BALB/c and C57BL/6, than in DBA/2 and CC57BR mice. Summarizing these facts the authors suppose that the differences in interleukin 2 production and acceptance play an important role in the height of lymphoproliferative response.
Pukhal'skiĭ
A L
AL
Toptygina
A P
AP
D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D006239:Haplotypes; D007376:Interleukin-2 / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics / Q000276:immunology; D008810:Mice, Inbred C57BL / Q000235:genetics / Q000276:immunology; D008811:Mice, Inbred DBA / Q000235:genetics / Q000276:immunology; D008815:Mice, Inbred Strains / Q000235:genetics* / Q000276:immunology; D013154:Spleen / Q000276:immunology*
D007376:Interleukin-2; D003208:Concanavalin A
Vysota proliferativnogo otveta na konkanavalin A kletok selezenki mysheĭ raznykh liniĭ i produktsiia interleĭkina-2.