title: Comparative evaluation of scavenger properties of exifone, piracetam and vinburnine.
abstract: The involvement of radical reactions in the ageing process, physiological as well as pathological, is well demonstrated. It is accepted that alloxan cyto-toxicity is linked to a production of hydroxylated free radicals and that a substance preventing the development of alloxanic diabetes possesses scavenger properties. The objective of this work was to demonstrate, in this model, the anti-radical effect of 3 molecules recommended in the treatment of cerebral insufficiency and a reference substance (+)-catechin. We observed a protective action with catechin (P less than 0.05) at the highest dose (100 mg/kg). PEG alone was moderately active but comparison of PEG-alloxan and PEG-exifone-alloxan showed a highly significant difference (P less than 0.001) at the two highest doses (60 and 120 mg/kg). Piracetam (200 and 400 mg/kg) and vinburnine (7.5 and 15 mg/kg) were inactive. Under these experimental conditions, exifone demonstrated remarkable anti-radical properties.
authors: Laboratory of Clinical and Experimental Pharmacology, Faculté de Médecine, Rennes, France.
authors: D
authors: D
authors: Bentue-Ferrer
authors: V
authors: V
authors: Philouze
authors: D
authors: D
authors: Pape
authors: J M
authors: JM
authors: Reymann
authors: H
authors: H
authors: Allain
authors: J
authors: J
authors: Van den Driessche
mesh_terms: D000818:Animals; D001577:Benzophenones / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D002392:Catechin / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology; D005609:Free Radicals; D008297:Male; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014748:Vinca Alkaloids / Q000494:pharmacology*
chemical_list: D001577:Benzophenones; D001786:Blood Glucose; D005609:Free Radicals; D011760:Pyrrolidinones; D014748:Vinca Alkaloids; C052932:exifone; D002392:Catechin; C016422:eburnamonine; D010889:Piracetam