Injurious effect of buthionine sulfoximine, an inhibitor of glutathione biosynthesis, on the lethality and urotoxicity of cyclophosphamide in mice.
The effect of buthionine sulfoximine (BSO), a glutathione biosynthesis inhibitor, on the acute lethal toxicity and urotoxicity induced by cyclophosphamide (CPA) was examined in mice. Pretreatment of mice with BSO (500 mg/kg, i.p.) 5 hr prior to CPA resulted in enhanced lethality and urotoxicity of CPA. In contrast, administration of cysteamine decreased the lethality and urotoxicity of CPA.
Ishikawa
M
M
Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku College of Pharmacy, Sendai, Japan.
Sasaki
K
K
Takayanagi
Y
Y
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D019328:Buthionine Sulfoximine; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005978:Glutathione / Q000096:biosynthesis*; D007928:Lethal Dose 50; D008297:Male; D008717:Methionine Sulfoximine / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D014570:Urologic Diseases / Q000139:chemically induced / Q000517:prevention & control*
D000963:Antimetabolites; D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D003520:Cyclophosphamide; D005978:Glutathione