[Value of immunohistochemical investigation of anti-GST-pi antibody in the early diagnosis of gastric carcinoma and precancerous lesion].
Human placental form of glutathione S-transferase (GST-pi) was detected in 38 human gastric carcinoma and 28 precancerous lesions by Avidin biotin peroxidase complex (ABC) method using anti-GST-pi antibody. Of 22 normal gastric mucosa, 91% were negative for GST-pi stain, 95% of 21 well and moderately differentiated gastric adenocarcinomas, all of 5 poorly differentiated gastric adenocarcinomas, 75% of undifferentiated gastric carcinomas, 85% of intestinal metaplasia and 100% of atypical hyperplasia were positive for GST-pi stain. These results indicate that GST-pi is a new sensitive marker for immunohistochemical detection of gastric carcinoma and precancerous lesion.
Yin
Z Z
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Department of Biochemistry, Yanbian Medical College, Yanji.
D000230:Adenocarcinoma / Q000175:diagnosis*; D000906:Antibodies / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D005982:Glutathione Transferase / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D010920:Placenta; D011230:Precancerous Conditions / Q000175:diagnosis*; D013274:Stomach Neoplasms / Q000175:diagnosis*
D000906:Antibodies; D014408:Biomarkers, Tumor; D005982:Glutathione Transferase