Negative evidence in vivo of DNA-damaging, mutagenic and chromosomal effects of eugenol.
The DNA-damaging, mutagenic and chromosomal effects of eugenol were assayed by the DNA alkaline elution technique, the granuloma pouch assay and the bone marrow micronucleus test in rats. With all the techniques used, eugenol did not show any genotoxic activity.
Maura
A
A
Institute of Pharmacology, University of Genoa, Italy.
Pino
A
A
Ricci
R
R
D000818:Animals; D005054:Eugenol / Q000633:toxicity*; D005260:Female; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D011919:Rats, Inbred Strains
D009153:Mutagens; D005054:Eugenol