Fine-needle aspiration cytology and immunocytochemistry of malignant non-Hodgkin's lymphoma in the oral cavity.
Fine-needle aspirates from 12 cases of malignant non-Hodgkin's lymphoma of the oral cavity were cytologically classified according to the Kiel classification. Ten lymphomas were high-grade and two were classified as being low-grade malignancies. Immunocytologic characterization on cytospin material showed that all cases were B-cell derived with monoclonal expression of immunoglobulin light chains. Surgical biopsy material was available for histologic diagnosis in 8 of 12 cases. In 5 of these, the cytomorphologic and the histologic diagnoses were in agreement. With respect to the other 3, one case was histologically classified as an unspecified malignancy and one as a centroblastic/centrocytic lymphoma, and in one case no malignant lesion could be found. The three cases were cytologically classified as large-cell centrocytic, centroblastic, and lymphoblastic lymphoma, respectively. We conclude that fine-needle aspiration cytology in conjunction with immunocytochemistry is a rapid, feasible, and atraumatic technique that is useful for diagnosing malignant lymphoma in the oral cavity.
Liliemark
J
J
Department of Medicine, Karolinska Institute, Huddinge Hospital, Sweden.
Tani
E
E
Mellstedt
H
H
Skoog
L
L
D000293:Adolescent; D000368:Aged; D000369:Aged, 80 and over; D001402:B-Lymphocytes / Q000473:pathology; D001707:Biopsy, Needle; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology*; D009367:Neoplasm Staging