Vanadate stimulates in vivo glucose uptake in brain and arrests food intake and body weight gain in rats.
Vanadate, administered via drinking fluid (0.2-0.8 mg/ml in 80 mM NaCl), attenuated food intake and strongly suppressed body weight gain in normally-fed or 20-hour food-deprived rats. At 0.8 mg/ml for 4 days, oral vanadate significantly stimulated the rate of hexose uptake by brain tissue. When microinjected into the lateral cerebral ventricle at a dose of 82 nmol, vanadate strongly and specifically suppressed food intake and body weight gain in 20-hour food deprived rats previously maintained on tap water. This inhibitory effect was reversed by coadministration of 3-O-methyl glucose. Collectively, the results suggest that vanadate is capable of blocking food intake by a specific effect in the central nervous system that involves stimulation of local glucose uptake.
Meyerovitch
J
J
Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.
Shechter
Y
Y
Amir
S
S
D019325:3-O-Methylglucose; D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects*; D005508:Food Deprivation; D005947:Glucose / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D008757:Methylglucosides / Q000494:pharmacology; D010710:Phosphates / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014638:Vanadates / Q000008:administration & dosage / Q000494:pharmacology*; D015430:Weight Gain / Q000187:drug effects*
D008757:Methylglucosides; D010710:Phosphates; D019325:3-O-Methylglucose; D014638:Vanadates; D005947:Glucose