[Effect of fenibut and seduxen on fetal development in the second half of pregnancy].
In experiments on rats it was found that fenibut (50 mg/kg, 1/20 of LD50) during a single and repeated administration in the fetus period of pregnancy does not exert any negative effect on the maternal organism, the growth and development of the fetus. Seduxen administered in a dose of 50 mg/kg (1/80 of LD50) alone and in combination with fenibut was shown to decrease the female body weight gain and to disturb the fetus development. Following a single administration on the 17th day of pregnancy, the effect was poorly pronounced.
Filimonov
V G
VG
Sheveleva
G A
GA
Strel'chenko
N V
NV
Sizov
P I
PI
Iasnetsov
V S
VS
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003975:Diazepam / Q000009:adverse effects*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D010012:Osteogenesis / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D014149:Tranquilizing Agents / Q000009:adverse effects*; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives*
D014149:Tranquilizing Agents; D005680:gamma-Aminobutyric Acid; D003975:Diazepam; C008842:4-amino-3-phenylbutyric acid
Issledovanie vliianiia fenibuta i seduksena na razvitie ploda vo vtoroĭ polovine beremennosti.