[HBsAg/PRE-S2 expression of viral replication and hepatic inflammation in chronic hepatitis B virus infection].
A close relationship (r = 0.186, P less than 0.025) was found between the serologic level of HBsAg/pre-S2, an envelope protein of hepatitis B virus, and the level of viral replication expressed by HBeAg. The rate of co-appearance and co-absence of both pre-S2 and HBeAg was 75.0%. Among HBeAg-positive cases, the prevalence of pre-S2 and its serologic level were significantly higher during exacerbation than resolution of chronic active hepatitis (73.3 vs 33.3%, 111.4 vs 1.4 ng/ml), and also higher than those among HBeAg-negative cases. Those the prevalence and the level were also higher in chronic active hepatitis than in chronic asymptomatic carriers (26.9 vs 11.5%, 2.95 vs 0.49 ng/ml). Pre-S2 prevalence in the group with highest scoring of histological activity was significantly higher than that in the groups with lower scoring (88.9 vs 40.0 and 36.4%) and the serologic level of pre-S2 also increased along with the scoring. Those data suggest that pre-S2 was associated with hepatic inflammatory activity as well.
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D000293:Adolescent; D000328:Adult; D000368:Aged; D002353:Carrier State / Q000382:microbiology; D005260:Female; D006509:Hepatitis B / Q000382:microbiology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000502:physiology; D006521:Hepatitis, Chronic / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000032:analysis*; D014779:Virus Replication
D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D011498:Protein Precursors; C050807:presurface protein 2, hepatitis B surface antigen