Potentiation of cathinone by caffeine and nikethamide.
The drug discrimination paradigm was employed to evaluate the effect of coadministration of both caffeine and nikethamide upon the discrimination of a low dose of cathinone. In rats trained to discriminate between 0.8 mg/kg l-cathinone and its vehicle in a two-lever food-motivated operant task, 0.2 mg/kg cathinone produced 29.2% of responses on the cathinone-appropriate lever. This lever was chosen in 0 and 50% of trials with 25 mg/kg nikethamide and 20 mg/kg caffeine, respectively. Coadministration of caffeine, nikethamide, or caffeine plus nikethamide with low-dose cathinone produced strong cathinone-like discriminative performance. This potentiattion of cathinone by caffeine and nikethamide is reflective of noncontrolled drugs of abuse containing similar combinations especially for that of antiadipositum X-112, a drug containing all three agents and widely abused in Europe.
Schechter
M D
MD
Department of Pharmacology, Northeastern Ohio University, College of Medicine, Rootstown 44272.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects*; D004338:Drug Combinations / Q000494:pharmacology; D004357:Drug Synergism; D008297:Male; D009552:Nikethamide / Q000494:pharmacology*; D010665:Phenylpropanolamine / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012459:Salicylates / Q000494:pharmacology
D000470:Alkaloids; D004338:Drug Combinations; D011619:Psychotropic Drugs; D012459:Salicylates; D010665:Phenylpropanolamine; D009552:Nikethamide; D002110:Caffeine; C023665:cathinone; C039440:antiadipositum X 112