HLA-DQw3 in Japanese summer-type hypersensitivity pneumonitis induced by Trichosporon cutaneum.
The phenotype of the major histocompatibility complex, loci A, B, C, DR, and DQ, was studied in 66 patients with Japanese summer-type hypersensitivity pneumonitis induced by Trichosporon cutaneum, and the results were compared with those obtained from 472 normal healthy subjects. Our results showed an increase in the frequency of HLA-DQw3 antigen in the patients (66% compared with 49% in the normal healthy control subjects: chi 2 = 5.48, p = 0.018, RR = 1.92), suggesting the importance of the host factors for the generation of this disease. The association between HLA-DQw3 as an immune suppression gene and the disease is discussed.
Ando
M
M
Department of Internal Medicine, Kumamoto University Medical School, Japan.
Hirayama
K
K
Soda
K
K
Okubo
R
R
Araki
S
S
Sasazuki
T
T
D000542:Alveolitis, Extrinsic Allergic / Q000276:immunology*; D002874:Chromosome Mapping; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D007564:Japan; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D012621:Seasons; D014250:Trichosporon
D006683:HLA-DQ Antigens; C051569:HLA-DQ3 antigen