[Effect of indomethacin on the immunological indices of patients with inoperable stomach cancer].
Immunoregulatory T-lymphocytes (T mu- and T gamma-lymphocytes) and circulating immune complexes were studied in inoperable patients with the stomach carcinoma of stages III-IV. It is established that the absolute number of T-lymphocytes, mainly of T-helpers/inductors increases after the administration of indomethacin and 5-fluorouracil with indomethacin. The T mu/T gamma-lymphocyte ratio increases and approaches the control values. The level of the circulating immune complexes tends to be normalized. The main effect of indomethacin is determined by the effect of T-lymphocytes on immunoregulatory subpopulations.
Moroz
T D
TD
Zinevich
A K
AK
Kas'ianenko
I V
IV
Moroz
V L
VL
D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000276:immunology; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D007213:Indomethacin / Q000627:therapeutic use*; D008875:Middle Aged; D012397:Rosette Formation; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000936:Antigen-Antibody Complex; D005472:Fluorouracil; D007213:Indomethacin
Vliianie indometatsina na immunologicheskie pokazateli u neoperabel'nykh bol'nykh rakom zheludka.