The effect of uptake inhibition on dopamine release from the nucleus accumbens of rats during self- or forced stimulation of the medial forebrain bundle: a microdialysis study.
Changes in dopamine (DA) release were measured in microdialysis samples taken from the nucleus accumbens (NAC) of rats pretreated with the DA uptake inhibitor, nomifensine (1 mg/kg, i.p.) during self- or forced stimulation of the medial forebrain bundle (MFB). Self-stimulation of the MFB in nomifensine-pretreated rats caused an increased release of DA in the NAC. In the same rats, similar increases in DA release were also found during forced stimulation, that is, during MFB stimulation in the absence of lever-pressing, but at current and rate parameters identical to those recorded in the previous self-stimulation session. The results indicate that self-stimulation of the MFB activates the mesolimbic DA system; similar neurochemical changes observed during self- and forced stimulation of the MFB suggest that the operant lever-pressing behavior itself did not influence DA release in the NAC.
Nakahara
D
D
Department of Psychology, Nagoya University College of Medical Technology, Japan.
Ozaki
N
N
Kapoor
V
V
Nagatsu
T
T
D000818:Animals; D003956:Dialysis; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D008297:Male; D008474:Medial Forebrain Bundle / Q000502:physiology*; D009627:Nomifensine / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation / Q000502:physiology*; D012686:Septal Nuclei / Q000378:metabolism*
D009627:Nomifensine; D004298:Dopamine