[Leigh's syndrome].
Leigh's syndrome is a degenerative nervous system disorder with well-characterized neuropathology. The clinical picture shows progressive neurologic deterioration in infancy leading to death from respiratory arrest. Mitochondrial enzymatic deficiencies are implicated in the pathogenesis of the disease. A 6-month-old male infant with progressive neurologic deterioration and brain findings at autopsy consistent with Leigh's syndrome is described.
Lerman-Sagie
T
T
Mukamel
M
M
Mimouni
M
M
D001344:Autopsy; D001921:Brain / Q000473:pathology; D001928:Brain Diseases, Metabolic / Q000473:pathology; D006801:Humans; D007223:Infant; D007888:Leigh Disease / Q000473:pathology; D008297:Male