[Comparative study of the effect of picamilone and piracetam on learning in rats in a radial maze].
During four weeks rats were learned to visit consequently 4 baited arms in the 8-armed radial maze. Picamilone (nicotinoyl-GABA) in a dose of 10 mg/kg daily accelerated rats to reach 80% level of learning (to 20-28 trials). After picamilone injections rats obtained the maximal level of short-term memory as just 3-5 trials. Piracetam in a dose of 200 mg/kg daily exerted no effects on long-term and short-term memory of rats in the radial maze.
Voznesenskiĭ
A G
AG
Kovalev
G V
GV
Sazhin
V A
VA
D000818:Animals; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D011760:Pyrrolidinones; C044905:nicotinoyl-GABA; D005680:gamma-Aminobutyric Acid; D010889:Piracetam
Sravnitel'noe izuchenie vliianiia pikamilona i piratsetama na obuchenie krys v radial'nom labirinte.