title: [Analysis of trace elements of the brain and liver tissues in Wilson's disease].
abstract: In a patients with extrapyramidal-cortical form of the Wilson-Konovalov disease, brain and liver tissues were tested for Ca, Cu, Fe, Ka, Mg, Mn, Mo, P, Pb, Se, Sn, Sz, Zn, S, using plasma emission spectrometry. The tissues autopsied from 2 cerebral hemorrhage victims served as controls. Hepatic Cu concentration was increased 24-fold (6.89 mumole/g of tissue dry weight); Cu accumulation in the brain cortex and basal ganglia were 10 times as high as control levels; hepatic (8.78 mumole/g) and brain cortical (2.23 mumole/g) Zn contents were higher than controls, respectively by factors of 2 and 1.7; hepatic S content (289.4 mumole/g) was 1.2 times the control level; Mn brain content was above the control value. Mg was below the appreciable amount in the brain that was not the case in control. On the contrary, Sr was detected only in basal ganglia and liver in the patient and not detected in control tissues. Pb content in the patient's liver was above the control level.
authors: T I
authors: TI
authors: Mzhe'lskaia
authors: E G
authors: EG
authors: Larskiĭ
authors: L A
authors: LA
authors: Pashchenko
authors: S P
authors: SP
authors: Gladkikh
authors: I A
authors: IA
authors: Ivanova-Smolenskaia
authors: E D
authors: ED
authors: Markova
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D006527:Hepatolenticular Degeneration / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013052:Spectrometry, X-Ray Emission; D014131:Trace Elements / Q000032:analysis / Q000378:metabolism*
chemical_list: D014131:Trace Elements
vernacular_title: Mikroélementnyĭ analiz tkaneĭ mozga i pecheni pri bolezni Vi'lsona-Konovalova.