title: Novel antitumor antibiotic phospholine. 1. Production, isolation and characterization.
abstract: Phospholine was isolated as an antitumor antibiotic from the fermentation broth of Streptomyces hygroscopicus. Phospholine is an amphoteric compound which has an amino group and a phosphoric acid ester as functional groups. Phospholine shows strong activities against L1210, P388 and EL-4.
authors: Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
authors: T
authors: T
authors: Ozasa
authors: K
authors: K
authors: Suzuki
authors: M
authors: M
authors: Sasamata
authors: K
authors: K
authors: Tanaka
authors: M
authors: M
authors: Kobori
authors: S
authors: S
authors: Kadota
authors: K
authors: K
authors: Nagai
authors: T
authors: T
authors: Saito
authors: S
authors: S
authors: Watanabe
authors: M
authors: M
authors: Iwanami
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D007783:Lactones / Q000302:isolation & purification / Q000627:therapeutic use; D007942:Leukemia, Experimental / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D009943:Organophosphorus Compounds / Q000302:isolation & purification / Q000627:therapeutic use; D013302:Streptomyces
chemical_list: D000903:Antibiotics, Antineoplastic; D007783:Lactones; D009943:Organophosphorus Compounds; C061212:phospholine