[Antifibrillatory effect of the calcium antagonist foridon in acute myocardial ischemia in conscious rabbits].
The effect of ryodipine on disorders of rhythm induced by occlusion of the left descending coronary artery was studied in experiments on 40 conscious immobilized rabbits. Ryodipine was injected intravenously (50 mcg/kg 5 minutes prior to and 25 mcg/kg after occlusion). Ventricular fibrillation developed in 19 (66%) rabbits of the control group and in 3 (27%) animals in the experimental group (p less than 0.03). The parameters of systemic and regional hemodynamics were studied in 7 rabbits of the control group and in 5 animals of the experimental group before and 30 minutes after occlusion; microspheres (15 mcm) labelled with various radioactive isotopes were used in the study. The blood flow in the intact myocardium of rabbits given ryodipine was higher than the initial level by 14% (p less than 0.05). The coronary fraction of the cardiac output increased by 21%. It is concluded that the antifibrillation effect of ryodipine is due to its favourable action on the myocardial blood flow.
Glukhovtsev
E V
EV
Dugin
S F
SF
Medvedev
O S
OS
Khodzhaev
A I
AI
D000818:Animals; D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011817:Rabbits; D014851:Wakefulness
D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D009543:Nifedipine; C045912:ryodipine
Antifibrilliatornoe deĭstvie antagonista kal'tsiia foridona pri ostroĭ ishemii miokarda u bodrstvuiushchikh krolikov.