[Isoenzymes of lactate dehydrogenase, alkaline phosphatase, creatine kinase. Possible use as tumor markers].
The electrophoresis of serum isoenzymes in cancer pathology at different stages has enabled us to recognise for LDH4 and LDH5, characteristics of sensitivity in all stages, with positivity greater than 60% in the advanced and multiply metastasized stages or with interference from other pathologies; to reveal portions pathologically heavy like FAST (46%); to reveal atypical bands (BB and MIT), as well as the values for normal or really low enzymatic activity. Through the elevated sensitivity and the high percentage of positivity, the isoenzymes LDH4 and LDH5 can be considered tumour markers and superior in validity to the conventional markers.
Scarazatti
E
E
Borroni
A
A
Melloni
C F
CF
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood*; D014408:Biomarkers, Tumor; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged
D014408:Biomarkers, Tumor; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D000469:Alkaline Phosphatase
Isoenzimi della lattato deidrogenasi, fosfatasi alcalina, creatin-chinasi. Possibilità di impiego come markers tumorali.