HLA-Bw60 increases susceptibility to ankylosing spondylitis in HLA-B27+ patients.
We examined the distribution of non-B27 alleles of the HLA-B locus among B27+ patients with ankylosing spondylitis (AS), to detect any additional HLA-B locus allele(s) that may act in conjunction with B27 to increase susceptibility to AS. HLA-Bw60 (or B40 when the Bw60,61 split of B40 was not typed for) was shown to be increased among B27+ AS patients in each of 5 independent data sets. This increase was statistically significant in 4 of the 5 data sets studied, and the overall significance was P less than 0.00001. Susceptibility to AS in B27+ individuals was further increased by a factor of approximately 3 when Bw60 was also present. The distribution of HLA-A alleles on the B27-bearing haplotypes in AS patients was not significantly different from that in normal controls. On the other hand, the distribution of HLA-A alleles on Bw60-bearing haplotypes was significantly different from the distribution of A alleles on Bw60 haplotypes in the general population (P less than 0.0005). Bw60 was not increased in B27- patients with AS. A dominant mode of inheritance generally fits AS; however, our sib pair analysis indicates that the B27,Bw60 disease subgroup follows a more recessive mode of inheritance.
Robinson
W P
WP
Department of Genetics, University of California, Berkeley 94720.
van der Linden
S M
SM
Khan
M A
MA
Rentsch
H U
HU
Cats
A
A
Russell
A
A
Thomson
G
G
D000483:Alleles; D002170:Canada; D004198:Disease Susceptibility; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen; D006239:Haplotypes; D006801:Humans; D009426:Netherlands; D009664:Norway; D010641:Phenotype; D013167:Spondylitis, Ankylosing / Q000235:genetics*; D013557:Switzerland; D014481:United States
D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; C081918:HLA-B60 antigen