title: Permeability of two nitrosoureas, carmustine and fotemustine in rat cortex.
abstract: Carmustine and fotemustine were perfused using a bolus retrograde infusion into the right external carotid artery of rats. The right jugular vein gave blood samples. Using a previously described method, nitrosoureas were continuously measured in rat brain by voltammetry and in blood samples by high-performance liquid chromatography for 15 min. Cerebrovascular permeability coefficients calculated in the first 2 min were 0.9.10(-4) cm.s-1 for carmustine and 0.5.10(-4) cm.s-1 for fotemustine. These high brain permeability coefficients were compared to literature values for carmustine and other nitrosoureas determined with a radioactive procedure.
authors: Faculté de Médecine Xavier-Bichat, Laboratoire de Biophysique, Paris, France.
authors: A
authors: A
authors: Meulemans
authors: B
authors: B
authors: Giroux
authors: P
authors: P
authors: Hannoun
authors: D
authors: D
authors: Henzel
authors: J P
authors: JP
authors: Bizzari
authors: J
authors: J
authors: Mohler
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D001812:Blood-Brain Barrier; D002199:Capillary Permeability; D002330:Carmustine / Q000493:pharmacokinetics*; D002540:Cerebral Cortex / Q000098:blood supply / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004730:Endothelium, Vascular / Q000378:metabolism; D007261:Infusions, Intra-Arterial; D009607:Nitrosourea Compounds / Q000493:pharmacokinetics*; D009943:Organophosphorus Compounds / Q000493:pharmacokinetics*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds; D009943:Organophosphorus Compounds; C054368:fotemustine; D002330:Carmustine