title: Flexor tendon pulley reconstructions--a histological and ultrastructural study in non-human primates.
abstract: The feasibility of A2 pulley reconstructions using expanded polytetrafluoroethylene (PTFE), woven nylon, and fascia lata was assessed in a non-human primate model and evaluated by light and scanning electron microscopy 18 weeks after implantation. No adhesions were found between reconstructed pulleys and flexor tendons. All types of pulley were intact and incorporated by host tissues, without evidence of a foreign body reaction. The inner surfaces of the fascial and PTFE pulleys, apposed to the gliding flexor tendons, were smooth and covered by a fibrous layer of tissue on microscopic and ultrastructural examination. The apposed visceral synovial surfaces of the F.D.P. tendon were indistinguishable from those from unoperated digits. The FDP tenosynovium apposed to woven nylon pulleys was more fibrillar and granular. Based on the results of the present study and on previous biomechanical data, expanded PTFE should be considered as a material for pulley reconstruction; it is incorporated by host tissues, elicits no foreign body reaction and causes no adhesions or traumatic changes to underlying flexor tendons. It is not yet known whether it has sufficient breaking strength to meet the functional demands of human pulleys.
authors: Division of Orthopaedic Surgery, Washington University School of Medicine.
authors: J
authors: J
authors: Dunlap
authors: J A
authors: JA
authors: McCarthy
authors: P R
authors: PR
authors: Manske
mesh_terms: D000818:Animals; D005205:Fascia / Q000637:transplantation*; D005206:Fascia Lata / Q000637:transplantation*; D008254:Macaca nemestrina / Q000601:surgery; D008855:Microscopy, Electron, Scanning; D009757:Nylons / Q000627:therapeutic use*; D011138:Polytetrafluoroethylene / Q000627:therapeutic use*; D013710:Tendons / Q000601:surgery* / Q000648:ultrastructure
chemical_list: D009757:Nylons; D011138:Polytetrafluoroethylene