Complement polymorphism in Greece.
The polymorphisms of the complement components C2, C3, C4 and BF have been studied in a sample of 166 unrelated individuals from Northern Greece. The C3*F and BF*F allele frequencies of Greeks are within the range of frequencies reported from Europe. A single individual with a rare heterozygote variant C2C/C2A was found in Greeks. This C2*A allele was found for the first time in European Caucasoids. For the C4 system six different alleles were found at both C4A and C4B loci. There were a low frequency of the null alleles at the C4A locus and a relatively high incidence of gene duplications in this system.
Triantaphyllidis
C D
CD
Division of Human Genetics, School of Pathological Sciences, University of Newcastle Upon Tyne, UK.
Ad'hiah
A
A
Karkousis
J
J
Papiha
S S
SS
D003175:Complement C2 / Q000235:genetics; D050678:Complement C2a; D003176:Complement C3 / Q000235:genetics; D015934:Complement C4a / Q000235:genetics; D015935:Complement C4b / Q000235:genetics; D011416:Complement Factor D / Q000235:genetics; D003165:Complement System Proteins / Q000235:genetics*; D005787:Gene Frequency; D006115:Greece; D006801:Humans; D005810:Multigene Family; D011110:Polymorphism, Genetic
D003175:Complement C2; D003176:Complement C3; D015934:Complement C4a; D015935:Complement C4b; D003165:Complement System Proteins; D050678:Complement C2a; C493488:CFD protein, human; D011416:Complement Factor D