Superior prevention of reinfarction by 30 mg per day aspirin compared with 1000 mg: results of a two years follow-up study in Cottbus.
The clearly significant overall results of the study indicating the superiority of the very low aspirin dose of 30 mg/d was differentiated by subgroup evaluations: The absolute benefit produced by the low aspirin dose was greatest among patients aged over 60, male patients, patients with a history of angina pectoris, patients with ST-depression of 0.5 mm or more in the 2th week after the cardiac event, among hypercholesterolaemic patients and those with all MI-locations except of the posterior site. The side effects were negligible (5% compared with 20-25% with 1000 mg/per day aspirin) and the drug costs are small. There was no evidence of any benefit of the high dose aspirin with respect to the odds of mortality and reinfarction.
Förster
W
W
Department of Pharmacology and Toxicology, Martin Luther-University Halle-Wittenberg, GDR.
Hoffmann
W
W
D000368:Aged; D001241:Aspirin / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D005859:Germany, East; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality / Q000517:prevention & control*; D011897:Random Allocation; D012008:Recurrence
D001241:Aspirin