Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill.
Since the isolation of an HIV-2-related virus from captive macaques (SIVMAC), the origin of human immunodeficiency viruses, a much debated subject, has been attributed to monkeys. The sequence of SIVAGM, which is derived from a naturally infected African green monkey, shows equal relatedness to HIV-1 and HIV-2, suggesting that the derivation of these viruses from SIVAGM is unlikely. Recent sequence analysis of SIV from a captive sooty mangabey (SIVMAC), however, shows its close relatedness to HIV-2 and SIVMAC, indicating a possible origin of HIV-2 and SIVMAC from SIVSM (refs 4, 7, 9). We report here the sequence of a novel simian lentivirus, SIVMND, isolated from a wild-caught mandrill in Africa. It is distinct from the three other main groups, HIV-1, HIV-2/SIVMAC/SIVSM and SIVAGM, and therefore represents a fourth main group of primate lentiviruses. Phylogenetic analysis indicates that these four main virus groups might have diverged from a common ancestor at about the same time, long before the spread of AIDS in humans.
Tsujimoto
H
H
Department of Animal Pathology, University of Tokyo, Japan.
Hasegawa
A
A
Maki
N
N
Fukasawa
M
M
Miura
T
T
Speidel
S
S
Cooper
R W
RW
Moriyama
E N
EN
Gojobori
T
T
Hayami
M
M
D000818:Animals; D005075:Biological Evolution; D005681:Gabon; D005814:Genes, Viral; D006678:HIV / Q000235:genetics; D008969:Molecular Sequence Data; D010215:Papio / Q000382:microbiology*; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000302:isolation & purification; D014764:Viral Proteins / Q000235:genetics
D012367:RNA, Viral; D014764:Viral Proteins