Cytogenetic characterization of a high-grade murine B-cell lymphoma.
The chromosomal pattern of a high-grade malignant B-cell lymphoma that arose spontaneously in a C57BL mouse is described. A considerable amount of structural chromosomal abnormalities was found in the lymphoma cells. These abnormalities are discussed in view of their possible role for oncogenesis, infiltration, and tissue distribution. The chromosomal findings of this lymphoma are compared with the few that have been described previously.
van Berlo
R J
RJ
Department of Human Genetics, State University of Groningen, The Netherlands.
Molenaar
W M
WM
de Jong
B
B
Lemstra
W
W
Dokter
J
J
Konings
A W
AW
D000818:Animals; D001402:B-Lymphocytes; D002869:Chromosome Aberrations; D005260:Female; D008223:Lymphoma / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL