Abnormal sperm assay tests on benzoin and caprolactam.
Benzoin and caprolactam, two noncarcinogenic chemicals found in association with consumer products, were tested in the mammalian in vivo abnormal spermhead assay. Each chemical was dissolved in a pharmaceutical grade corn oil and administered by gavage. Toxic effects were observed only with caprolactam-treated mice. Neither benzoin nor caprolactam induced a significant increase in the frequency of abnormal sperm as compared to that for animals treated only with the corn oil.
Salamone
M F
MF
Ontario Ministry of the Environment, Biohazard Laboratory, Rexdale, Canada.
D000818:Animals; D001381:Azepines / Q000633:toxicity*; D001573:Benzoin / Q000633:toxicity*; D002209:Caprolactam / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009152:Mutagenicity Tests; D009153:Mutagens; D013094:Spermatozoa / Q000187:drug effects*
D001381:Azepines; D009153:Mutagens; D002209:Caprolactam; D001573:Benzoin