title: [Disorders of the immune system in benign lesions and cancer of the breast].
abstract: Immunologic vigor was studied in 225 cases of breast cancer at various stages, 99 patients with benign lesions of the breast and 154 healthy donors. The parameters of cell-mediated immunity under study included total, active and neuraminidase T-lymphocyte levels, concentration of T-lymphocyte subsets (Tm, T gamma, theophylline--sensitive and theophylline--resistant) and their profile, functional activity of lymphocytes in blastogenic reaction with PHA and natural killer levels. Also, such humoral immunity indexes as B-lymphocytes and immunoglobulins A, M and C were evaluated. Significant changes in functional activity of the immune system (mainly, its T-cell--mediated component) were identified as early as at the initial stages of breast cancer development and they became more pronounced as tumor advanced. Also, at initial stages, both T-lymphocyte and natural killer functional activity started to flag.
authors: N A
authors: NA
authors: Derevnina
authors: E B
authors: EB
authors: Polevaia
authors: T K
authors: TK
authors: Veskova
authors: L P
authors: LP
authors: Trubcheninova
authors: V N
authors: VN
authors: Bogatyrev
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D001941:Breast Diseases / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology*; D005260:Female; D007136:Immunoglobulins / Q000032:analysis; D007694:Killer Cells, Natural / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
chemical_list: D007136:Immunoglobulins
vernacular_title: Narusheniia v sisteme immuniteta pri dobrokachestvennykh izmeneniiakh i rake molochnoĭ zhelezy.