title: Emergency lung biopsy in immunocompromised pediatric patients.
abstract: Twenty-six lung biopsies were performed on immunocompromised children with interstitial pneumonia over a 4-year period. More than 50% of the patients had either bone marrow transplants or immunodeficiency syndromes. Biopsy diagnosis included viral (9), nonspecific interstitial pneumonitis (9), Pneumocystis carinii (7), and bacterial (1) etiologies. Findings caused a change in treatment in 15 (58%) patients, and nine of these 15 (60%) survived. Survivors included five children with viral infections treated with antiviral agents. Only one of nine patients requiring preoperative intubation survived, while 11 of 17 (65%) not intubated before operation survived. Overall survival was 46% and included 5 of 5 patients with leukemia, 2 of 3 patients with liver transplants, 2 of 6 patients with immunodeficiency syndromes, and 1 of 8 patients with bone marrow transplants. This report shows that (1) an infectious etiology was found in 65% of the cases; (2) there was a high incidence of viral pneumonitis; (3) biopsy indicated a change in treatment for the majority of the patients; (4) the change in treatment was associated with survival in 60%; (5) viral infections may be effectively treated; and (6) the timely use of lung biopsy is an important adjunct in the diagnostic and therapeutic regimen for immunocompromised children with interstitial pneumonia.
authors: Department of Surgery, UCLA School of Medicine 90024.
authors: R P
authors: RP
authors: Foglia
authors: J
authors: J
authors: Shilyansky
authors: E W
authors: EW
authors: Fonkalsrud
mesh_terms: D000293:Adolescent; D001424:Bacterial Infections / Q000150:complications / Q000175:diagnosis; D001706:Biopsy / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D004630:Emergencies; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D007223:Infant; D008168:Lung / Q000473:pathology*; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000175:diagnosis; D011024:Pneumonia, Viral / Q000150:complications / Q000175:diagnosis; D011658:Pulmonary Fibrosis / Q000175:diagnosis* / Q000209:etiology