title: Pharmacokinetics of a nitrofuran compound, nifurtimox, in healthy volunteers.
abstract: Nifurtimox disposition was evaluated in 7 healthy volunteers. Each subject received an oral dose of 15 mg/kg of nifurtimox and blood sample was obtained 11 h after the drug administration. We used an analytical method previously assessed in the literature. The pharmacokinetic analysis was carried out according to a one-compartment model and the most important parameters established were elimination half-life, distribution volume, and clearance. Serum concentrations were low in relation to the high doses administered. The low serum concentration is probably the result of a marked first pass effect.
authors: Department of Science and Pharmaceutical Technology, Faculty of Chemistry and Pharmaceutical Science, University of Chile, Santiago.
authors: C
authors: C
authors: Paulos
authors: J
authors: J
authors: Paredes
authors: I
authors: I
authors: Vasquez
authors: S
authors: S
authors: Thambo
authors: A
authors: A
authors: Arancibia
authors: G
authors: G
authors: Gonzalez-Martin
mesh_terms: D000328:Adult; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008954:Models, Biological; D009547:Nifurtimox / Q000493:pharmacokinetics*; D009581:Nitrofurans / Q000493:pharmacokinetics*
chemical_list: D009581:Nitrofurans; D009547:Nifurtimox