title: [In vivo protective action of urinastatin during extracorporeal circulation].
abstract: A patient undergoing extracorporeal circulation is in the state of controlled shock. The object of the present study is to investigate the prophylactic effect of ulinastatin (6000 U.kg-1 or 12000 U.kg-1 during extracorporeal circulation by a randomized study. Although the ratio of lactic acid/pyruvic acid did not show significant changes, the increase was inhibited in 12000 U.kg-1 treated group. In 12000 U.kg-1 treated group, beta-glucuronidase reflecting the function of lysosomal membrane, as well fibronectin reflecting the endothelial function, were suppressed. The results of the present study indicate that administration of ulinastatin 12000 U.kg-1 is effective and useful for the organism.
authors: T
authors: T
authors: Arima
authors: M
authors: M
authors: Matsuura
authors: M
authors: M
authors: Ohata
authors: T
authors: T
authors: Shiramatsu
authors: I
authors: I
authors: Matsumoto
authors: T
authors: T
authors: Hori
mesh_terms: D005112:Extracorporeal Circulation; D005260:Female; D006023:Glycoproteins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012773:Shock, Surgical / Q000517:prevention & control*; D014361:Trypsin Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D006023:Glycoproteins; D014361:Trypsin Inhibitors; C028665:urinastatin