Adoptive transfer of tsk skin fibrosis to +/+ recipients by tsk bone marrow and spleen cells.
The tight skin mouse (Tsk/+) is an autosomal dominant example of inherited fibrosis whose pathogenesis is unclear. Autoimmune phenomena have been described previously. This study demonstrates the adoptive transfer of skin fibrosis to lethally irradiated syngeneic +/+ recipients by the transplantation of both bone marrow and spleen cells. The recipient skin fibrosis was not associated with mast cell proliferation or degranulation as it is in the tsk/+ mouse, representing for the first time a dissociation between mast cells and fibrosis and introducing the potential for direct T cell-fibroblast interactions.
Walker
M A
MA
Department of Medicine, Medical University of South Carolina, Charleston 29425.
Harley
R A
RA
DeLustro
F A
FA
LeRoy
E C
EC
D000818:Animals; D016026:Bone Marrow Transplantation; D005355:Fibrosis; D007116:Immunization, Passive; D017710:Lymphocyte Transfusion; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D012016:Reference Values; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000235:genetics* / Q000276:immunology; D013154:Spleen / Q000637:transplantation