[Initial results of immunotherapy approaches to tumor treatment in the animal model].
The possibilities of using immunocytes in cancer therapy have been increasing during the last few years. Contrary to the promising results gained by in vitro experiments, several clinical trials have shown that, on the one hand, it is difficult to preserve a quantity of cells big enough to inhibit tumours, and they have also shown that, on the other hand, antitumour lymphocytes do not get into the tumour. That is why we concentrated on improving the tumour selectivity of the antitumour lymphocytes. We carried this out practising two sets of experiments. First we incubated patient lymphocytes with tumour extract and vaccinated them in this manner. Secondly, by binding antitumour antibodies to lymphocytes, we could improve the ability of lymphocytes to bind with tumour cells. We tested these therapy models on human tumours and on tumour cell lines. Both were implanted in the renal capsule space of nude mice.
Kau
R J
RJ
Universitäts-HNO-Klinik Düsseldorf.
Kürten
C
C
Kumazawa
H
H
Koldovsky
P
P
D000230:Adenocarcinoma / Q000628:therapy; D000368:Aged; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D002460:Cell Line; D002470:Cell Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D007116:Immunization, Passive; D015979:Killer Cells, Lymphokine-Activated / Q000637:transplantation*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D013370:Subrenal Capsule Assay
Erste Ergebnisse immuntherapeutischer Ansätze zur Tumorbehandlung im Tiermodell.