[Anti-allergic properties of pipethiaden--a new preventive agent for migraine].
Pipethiadene, a prophylactic of vasomotoric headaches of the series of 4,9-dihydrothieno(2,3-c)-2-benzothiepine derivatives, shows a peripheralpharmacological profile of an antiallergic agent. The experiments in rats showed a high antianaphylactic effect of pipethiadene in the passive cutaneous anaphylaxis (PCA) test. Pipethiadene also exerted intensive antianaphylactoid action in rats on the liberator of histamine, compound 48/80, on dextran, and in the use of a combination of ovalbumin with indomethacin. In comparative pharmacological experiments with pizotifen and cyproheptadine an attempt was made to estimate the relative role of histamine and 5-hydroxytryptamine 5-HT) mediators in the employed experimental procedures in rats.
Frycová
H
H
Metys
J
J
D000707:Anaphylaxis / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D003533:Cyproheptadine / Q000627:therapeutic use; D005260:Female; D006168:Guinea Pigs; D051379:Mice; D008881:Migraine Disorders / Q000517:prevention & control; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D010880:Piperidines / Q000627:therapeutic use*; D010918:Pizotyline / Q000627:therapeutic use; D051381:Rats
D010880:Piperidines; D010918:Pizotyline; D003533:Cyproheptadine; C045300:pipethiaden
Antialergické vlastnosti pipethiadenu--nového profylaktika migrény.