title: [Changes in biliary lithogenicity caused by 4 weeks' weight reduction].
abstract: In 2 of 12 patients (16.6%) cholesterol monohydrate crystals occurred in duodenal bile samples after a 4 weeks fasting period (452 kcal/day). Cholesterol monohydrate crystals could be observed until recently mainly in patients with cholesterol gallstones. Therefore, this finding indicates increased biliary lithogenicity despite a non statistical decrease in CSI from 1.35 +/- 0.35 to 1.19 +/- 0.64. Presumably the increased lithogenicity may be caused by an increased glycoprotein concentration and an improvement in gallbladder contractility. Short time fasting obviously will be a risk factor for the development of gallstones, if weight and metabolic normalisation cannot be achieved.
authors: Abteilung Innere Medizin II der Universität Ulm.
authors: P
authors: P
authors: Janowitz
authors: W
authors: W
authors: Swobodnik
authors: J G
authors: JG
authors: Wechsler
authors: K
authors: K
authors: Kuhn
authors: H
authors: H
authors: Wenzel
authors: H
authors: H
authors: Wenk
authors: H
authors: H
authors: Ditschuneit
mesh_terms: D000328:Adult; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D002769:Cholelithiasis / Q000209:etiology* / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000178:diet therapy / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D015431:Weight Loss
chemical_list: D001647:Bile Acids and Salts; D010743:Phospholipids; D002784:Cholesterol
vernacular_title: Veränderungen der biliären Lithogenität während einer vierwöchigen Gewichtsreduktion.