title: Calcium chloride inhibits stimulation of replicative DNA synthesis by sodium chloride in the pyloric mucosa of rat stomach.
abstract: Calcium chloride (CaCl2) inhibits stimulation of replicative DNA synthesis (RDS) induced in the pyloric mucosa of male Fischer 344 rats by sodium chloride (NaCl), which is a tumor promoter in the glandular stomach. Administration of 1 ml of 3.3 M NaCl by gastric intubation induced a maximal 15-fold increase in RDS in the pyloric mucosa by 17 h; this had returned to the control level by 48 h. Administration of 1 ml of 20-400 mM CaCl2 1 h before administration of NaCl resulted in a 60-100% inhibition of the increase in RDS within 4-48 h; the inhibition was dose-dependent. The 400 mM level of CaCl2 also decreased the histological damage to surface epithelial cells induced by NaCl. These results suggest that calcium ion acts as an anti-tumor promoter in stomach carcinogenesis.
authors: Department of Molecular Oncology, University of Tokyo, Japan.
authors: C
authors: C
authors: Furihata
authors: K
authors: K
authors: Sudo
authors: T
authors: T
authors: Matsushima
mesh_terms: D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology*; D002273:Carcinogens; D004261:DNA Replication / Q000187:drug effects*; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D011706:Pyloric Antrum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D012965:Sodium Chloride / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000139:chemically induced; D013997:Time Factors
chemical_list: D002273:Carcinogens; D012965:Sodium Chloride; D002122:Calcium Chloride