[Lipid peroxidation and the major factors of its activation in patients with myocardial infarction].
A dynamic study of 97 patients with primary macrofocal myocardial infarction (MI) has demonstrated that activated lipid peroxidation (LPO) is an important pathogenetic element of MI, with LPO level reflecting major stages of the disease and its complications. In acute MI, LPO activation depends on the magnitude of the stress syndrome and the severity of arterial hypoxia and is mediated by gas exchange disorders in the pulmonary circulation network. The passage of LPO products from ischemized myocardium to systemic circulation is also of significance. In the scarring phase, LPO activation is due to circulatory hypoxia associated with reduced cardiac contractility. The markedness of leucocytic response is an important factor of MI-associated LPO activation. The extent of LPO disorders is largely limited by the antioxidant system of the body.
Golikov
A P
AP
Polumiskov
V Iu
VIu
Davydov
B V
BV
Karev
V A
VA
Bashkatova
V G
VG
Belozerov
G E
GE
Golikov
P P
PP
Berestov
A A
AA
D000328:Adult; D000368:Aged; D000975:Antioxidants; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D014811:Vitamin E Deficiency / Q000150:complications / Q000378:metabolism*
D000975:Antioxidants
Perekisnoe okislenie lipidov i osnovnye faktory ego ektivatsii u bo'lnykh infarktom miokarda.