Spontaneous hypoparathyroidism: clinical, biochemical and radiological features.
The clinical, biochemical and radiological features of spontaneously occurring hypoparathyroidism in 13 patients (mean age 9 years, range 4 months to 20 years) are highlighted. Nine patients presented with a history of generalised seizures and 2 were in acute hypocalcemic crisis at the time of admission. Ocular involvement (corneal opacities, cataract) was present in 3 patients and vitiligo in 1 patient. The serum calcium level was low (mean 5.46 mg/dl, range 5.0-7.2) and serum phosphorus level was high (mean 8.49 mg/dl, range 6-14 mg/dl) in all the patients. Six patients had elevated serum alkaline phosphatase (greater than 20 KAU). Radiological examination revealed osteopenia in 3 patients. Nine patients underwent a head CT scan; 5 had evidence of basal ganglia calcification. The findings of elevated serum alkaline phosphatase and osteopenia are at variance with existing literature and may possibly reflect pre-existing vitamin D deficiency.
Mithal
A
A
Menon
P S
PS
Ammini
A C
AC
Karmarkar
M G
MG
Ahuja
M M
MM
D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001480:Basal Ganglia Diseases / Q000201:enzymology / Q000208:ethnology; D001851:Bone Diseases, Metabolic / Q000201:enzymology / Q000208:ethnology; D002114:Calcinosis / Q000201:enzymology / Q000208:ethnology; D002648:Child; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000201:enzymology / Q000208:ethnology; D007194:India; D007223:Infant; D008297:Male; D012640:Seizures / Q000201:enzymology / Q000208:ethnology
D000469:Alkaline Phosphatase