Calcium metabolism in Alzheimer's disease. A case-control study.
Aluminium is present in senile plaques and in neurofibrillary tangle-bearing neurones in brains of cases of Alzheimer's disease. Evidence linking aluminium absorption to calcium metabolism prompted a case-control study of physiological markers of calcium homeostasis in patients with Alzheimer's disease. Mean plasma 25-hydroxyvitamin D concentration was lower in cases than in controls but no difference in median parathyroid hormone concentrations or other evidence of altered calcium metabolism was found. The difference in 25-hydroxyvitamin D concentrations may be secondary to differences in exposure to sunlight.
Martyn
C N
CN
MRC Environmental Epidemiology, Southampton General Hospital, UK.
Singh
S
S
Wood
P J
PJ
D015652:25-Hydroxyvitamin D 2 / Q000097:blood; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000453:epidemiology / Q000378:metabolism*; D015992:Body Mass Index; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D010281:Parathyroid Hormone / Q000097:blood; D006113:United Kingdom
D010281:Parathyroid Hormone; D015652:25-Hydroxyvitamin D 2; D002118:Calcium