Suppression of anaphylactic shock in sensitized guinea pigs by cytochalasin B.
Twenty-three guinea pigs, presensitized with horse serum, were injected intracardially with 1 ml of 1.5 X 10(-4) M cytochalasin B in a 2.5% dimethyl sulfoxide solution, 1.5 h before being challenged with the serum. Eighteen of the guinea pigs (80%) survived. A single intracardiac injection of cytochalasin B to the control group of guinea pigs at 1.5 h before administration of the allergen did not prevent their sensitization and death following challenge.
Stefani
D V
DV
Moscow Research Institute of Pediatrics and Pediatric Surgery, Ministry of Health of the Russian Soviet Federated Socialist Republic.
Veltishchev YuE
Semyonov
A V
AV
Kudrina
G P
GP
D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D003571:Cytochalasin B / Q000008:administration & dosage / Q000494:pharmacology*; D006168:Guinea Pigs
D003571:Cytochalasin B