Pharmacologic modulation of acute ocular inflammation with quercetin.
Anti-inflammatory potentials of a safe, common dietary component, quercetin, were investigated in suppression of intraocular inflammation induced by retinal S antigen. Lewis rats sensitized to S antigen were treated daily with intraperitoneal injections of quercetin. Control rats with S-antigen-induced uveitis were similarly treated with diluent. When compared with controls the treated group showed marked reduction in uveal and retinal inflammation and in vasculitis and perivasculitis. Morphometric analysis revealed a significant reduction (p less than 0.005) in choroidal thickness when compared with that of control animals. These results clearly show the antiphlogistic effects of quercetin in experimental uveitis.
Romero
J
J
Doheny Eye Institute, Department of Ophthalmology, University of Southern California, Los Angeles.
Marak
G E
GE
Rao
N A
NA
D000818:Animals; D000941:Antigens; D019393:Arrestin; D002829:Choroid / Q000473:pathology; D005136:Eye Proteins; D005419:Flavonoids / Q000494:pharmacology*; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D012173:Retinitis / Q000473:pathology / Q000517:prevention & control*; D013997:Time Factors; D014605:Uveitis / Q000473:pathology / Q000517:prevention & control*
D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins; D005419:Flavonoids; D011794:Quercetin