[Quantitative "structure-antimicrobial activity" relations of the new azole derivatives].
New azole derivatives are synthesized and examined with the purpose of searching antimicrobic drugs and of determining the quantitative structure--activity relationships. Their antifungal and antibacterial activity is fixed. Certain regularities of the relationships between the chemical structure of compounds and their activity are determined by the Free-Wilson model. The influence of aryl and alkyl radicals in 1.2 and 5 positions of azoles on antimicrobial properties is discussed. Prospects for the further studies of this group of chemicals are shown.
Patratiĭ
V K
VK
Sinchenko
V G
VG
Prodanchuk
N G
NG
Butkovskiĭ
Iu V
IuV
Drach
B S
BS
D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D001393:Azoles / Q000138:chemical synthesis / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D001393:Azoles
Kolichestvennye zavisimosti "struktura-protivomikrobnaia aktivnost'" dlia novykh proizvodnykh azolov.