[The effect of glycerol on regional cerebral blood flow, blood volume and oxygen metabolism].
Using positron emission tomography with 15O-labelled CO2 O2 and CO gases, the effects of glycerol on regional cerebral blood flow (CBF), blood volume (CBV) and oxygen metabolism (CMRO2) were investigated in 6 patients with meningioma accompanying peritumoral brain edema. The same study was done in 5 normal volunteers. The changes of blood gases, hematocrit and hemoglobin were also examined. After a drip infusion of glycerol, the regional CBF increased not only in the peritumoral cortex and white matter but also in the intact cortex and white matter on the contralateral side. The increase of CBF was extensive and substantially there were no regional differences. In contrast, the changes of CMRO2 were not significant. This was derived from the increase in oxygen extraction fraction throughout extensive areas including the peritumoral area. There were no changes in CBV. Hematocrit and hemoglobin decreased to a small degree. In the normal volunteers, the same findings were noted. Thus, glycerol increases the functional reserve for cerebral oxygen metabolism, not only in the peritumoral regions but also in the intact regions. The effects of glycerol on hemodynamics and metabolism were discussed with reference to some differences from mannitol.
Ishikawa
M
M
Division of Surgical Operation Service, Kyoto University Hospital.
Kikuchi
H
H
Nagata
I
I
Yamagata
S
S
Taki
W
W
Kobayashi
A
A
Yonekura
Y
Y
Nishizawa
S
S
D000328:Adult; D001810:Blood Volume / Q000187:drug effects*; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005990:Glycerol / Q000494:pharmacology*; D006801:Humans; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D008579:Meningioma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects*; D010104:Oxygen Radioisotopes; D014055:Tomography, Emission-Computed
D010104:Oxygen Radioisotopes; D005990:Glycerol