[Interleukin 2-stimulated formation of ATP in T cell particles enriched with plasma membranes].
Distinct increase in content of ATP was found in preparations of enriched with plasmatic membranes particles from rat thymus T lymphocytes and from human peripheric blood T lymphocytes after their incubation with interleukin-2 as compared with controls which did not contain the peptide. The phenomenon observed was manifested only if these particles from T cells were preincubated with concanavalin A (2 min, 40 micrograms/ml), which is required to expression of the receptors for interleukin-2. The membrane-bound ATP, formed after the interleukin-2 effect on receptors of T lymphocytes, appears to serve as the secondary messenger activating protein kinase C.
Karelin
A A
AA
Demidova
V S
VS
Globa
A G
AG
Marchuk
A I
AI
Vtiurin
B V
BV
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003208:Concanavalin A; D005786:Gene Expression Regulation; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008297:Male; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D015375:Receptors, Interleukin-2 / Q000235:genetics; D013601:T-Lymphocytes / Q000378:metabolism*; D013950:Thymus Gland / Q000378:metabolism
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D003208:Concanavalin A; D000255:Adenosine Triphosphate; D011493:Protein Kinase C
Stimuliruemoe interleĭkinom-2 obrazovanie ATF preparatami obogashchennykh plazmaticheskimi membranami chastits iz t-kletok.