title: Mode of alloantibody-mediated blockade of allo-sensitization for tumor allograft rejection.
abstract: The mode of alloantibody-mediated inhibition of allo-sensitization for tumor allograft rejection was studied. Relatively small amounts of anti-H-2d alloantiserum administered shortly before or after injection of allogeneic spleen cells blocked the allo-sensitization for second-set tumor allograft rejection. In contrast, the alloantiserum injected shortly before inoculation of tumor barely enhanced the tumor growth. The passively administered alloantiserum inhibited the sensitization for allospecific cytotoxic T lymphocyte responses in vitro. Further study revealed that the allo-sensitization could be blocked with antiserum specific against only one of the expressed H-2 antigens on stimulator cells. Correspondingly, H-2Dd-monospecific monoclonal antibody (IgG2a) was effective in inhibiting the sensitization with cells expressing multiple H-2 alloantigens. These results suggest that antibody-mediated inactivation of stimulator cells as a whole is an important mechanism of the allograft enhancement.
authors: Department of Immunology, Nagoya University School of Medicine, Japan.
authors: H
authors: H
authors: Lai
authors: Y
authors: Y
authors: Hasegawa
authors: K
authors: K
authors: Mizoguchi
authors: T
authors: T
authors: Yoshida
authors: K
authors: K
authors: Isobe
authors: K
authors: K
authors: Shimokata
authors: K
authors: K
authors: Kawashima
authors: I
authors: I
authors: Nakashima
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D001667:Binding, Competitive; D006084:Graft Rejection; D006183:H-2 Antigens; D007518:Isoantibodies; D007939:Leukemia L1210 / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014184:Transplantation, Homologous
chemical_list: D000911:Antibodies, Monoclonal; D006183:H-2 Antigens; D007518:Isoantibodies