[Evaluation of clinical and neurophysiological markers of depressive disorder with symptoms of peripheral and brain circulation disturbance].
The evaluation of neurophysiological markers during imipramine treatment of 60 patients with endogenous depression was made. These markers were evaluated in 2 groups of patients: with cardio-vascular, and with brain circulation disturbances; both groups equal 30 subjects. During thymoleptic treatment of patients with circulation disturbances, elevated level of anxiety and statistically significant lower simple and complex reactivity of central nervous system were found. Such reactivity did not improve during the treatment in this group of patients. The lack of improvement of above mentioned parameters under imipramine may be the factor that elucidates the pathomechanism of chronic course of depression in old age. The improvement of circulation conditions, along with the thymoleptic therapy, should have the crucial importance for the therapeutic effect.
Strzyzewski
W
W
Rajewski
A
A
Sydor
L
L
Zelechowska-Ruda
E
E
Jaracz
J
J
D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications / Q000503:physiopathology*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000503:physiopathology*; D002908:Chronic Disease; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D007099:Imipramine
Ocena wykładników klinicznych i neurofizjologicznych zespołów depresyjnych z objawami zaburzeń w krãzeniu obwodowym i mózgowym krwi.