[Benzonal metabolism in guinea pigs].
A metabolite of an anticonvulsant drug Benzonal was isolated from the guinea pig blood serum and identified by high performance liquid chromatography (HPLC). By using HPLC as well as ultraviolet-, infrared- and mass-spectrometry it was established that in the guinea pig intestine Benzonal undergoes alkaline hydrolysis with the formation of phenobarbital. The native Benzonal in the guinea pig blood serum was not found.
Okudzhava
V M
VM
Chankvetadze
B G
BG
Rogava
M M
MM
Dzhikiia
N Iu
NIu
Lomsadze
K T
KT
D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism*; D001463:Barbiturates / Q000378:metabolism*; D006168:Guinea Pigs; D006868:Hydrolysis; D010634:Phenobarbital / Q000378:metabolism; D014018:Tissue Distribution
D000927:Anticonvulsants; D001463:Barbiturates; C002915:benzobarbital; D010634:Phenobarbital
Metabolizm benzonala u morskikh svinok.