title: Fast atom bombardment mass spectrometry and selective acid hydrolysis for the analysis of partially modified retro-inverso peptide analogues.
abstract: Fast atom bombardment (FAB) mass spectrometry has been successfully applied to the analysis of partially modified retro-inverso peptide isomers. The spectra are characterized by abundant protonated molecular ions and also by sequence ions due to fragmentation of the inverted bonds. Unambiguous information, as to the nature and the position in the backbone of the amino acids involved in the partial modification of the structure, are given by using a combination of FAB mass spectrometry and partial, selective acid hydrolysis, without separation of the resulting peptide mixtures.
authors: Dipartimento di Chimica, Università La Sapienza, Roma, Italy.
authors: F
authors: F
authors: De Angelis
authors: S
authors: S
authors: Ceccarelli
authors: G C
authors: GC
authors: Viscomi
authors: M
authors: M
authors: Pinori
authors: A S
authors: AS
authors: Verdini
mesh_terms: D006868:Hydrolysis; D007536:Isomerism; D013058:Mass Spectrometry; D010455:Peptides / Q000032:analysis*; D013237:Stereoisomerism
chemical_list: D010455:Peptides