title: Autogenous oscillatory potentials in neurons of the guinea pig substantia nigra pars compacta in vitro.
abstract: In spontaneously firing neurons of the guinea pig substantia nigra pars compacta (SNC) maintained in slices, blockade of the fast spikes by tetrodotoxin (TTX) revealed a slow oscillatory potential change, which was depressed by Cd2+, a Ca2+-channel blocker. The spontaneous firing was suppressed by the application of Ca2+-free saline, Cd2+ or Co2+, but not by nifedipine. These findings lend support to the view that the spontaneous firing of SNC neurons is produced by an intrinsic, Ca2+-dependent pacemaking process affected by Cd2+ but not by nifedipine.
authors: Department of Physiology, Nagasaki University School of Medicine, Japan.
authors: K
authors: K
authors: Fujimura
authors: Y
authors: Y
authors: Matsuda
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D019256:Cadmium Chloride; D002118:Calcium / Q000494:pharmacology; D003035:Cobalt / Q000494:pharmacology; D006168:Guinea Pigs; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009543:Nifedipine / Q000494:pharmacology; D013378:Substantia Nigra / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D002104:Cadmium; D003035:Cobalt; D013779:Tetrodotoxin; D009543:Nifedipine; D019256:Cadmium Chloride; D002118:Calcium