title: Immunohistochemical study of peripolar cells of the sheep.
abstract: The proposal that the cytoplasmic granules of glomerular peripolar cells (PPCs) of the adult sheep and lamb contain a kallikrein-like substance has been re-examined. After extensive characterisation and purification of anti-kallikrein antibodies, it was concluded that PPCs do not contain immunohistochemically detectable amounts of urinary kallikrein; nor do such cells appear to synthesise kallikrein as shown by hybridisation histochemistry studies. They are also not renin-immunopositive. On the other hand, a proportion of them exhibit neuron-specific enolase (NSE) immunoreactivity, unlike the apparently closely related visceral and parietal epithelial cells.
authors: Department of Anatomy, University of Melbourne, Parkville, Victoria, Australia.
authors: J F
authors: JF
authors: Trahair
authors: J A
authors: JA
authors: Gall
authors: D
authors: D
authors: Alcorn
authors: J P
authors: JP
authors: Coghlan
authors: R
authors: R
authors: Fernley
authors: J
authors: J
authors: Penschow
authors: L P
authors: LP
authors: Grattage
authors: C I
authors: CI
authors: Johnston
authors: G B
authors: GB
authors: Ryan
mesh_terms: D000818:Animals; D003594:Cytoplasmic Granules / Q000032:analysis; D007150:Immunohistochemistry; D007610:Kallikreins / Q000032:analysis*; D007668:Kidney / Q000032:analysis* / Q000166:cytology; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D012756:Sheep
chemical_list: D007610:Kallikreins; D010751:Phosphopyruvate Hydratase