Heterogeneity in Alzheimer's disease.
The phenotype of Alzheimer's disease is variable. Age of onset, cognitive features, and neuropathology differ case to case. In some cases the differences are due to variable expression and others to genetic heterogeneity. Present evidence suggests four types of Alzheimer's disease: early and late onset autosomal dominant forms, trisomy 21, and phenocopies.
Folstein
M F
MF
Johns Hopkins University School of Medicine, Baltimore, MD.
D000328:Adult; D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D000647:Amnesia / Q000209:etiology*; D001037:Aphasia / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D013577:Syndrome