title: Interleukin 2 and interleukin 2 inhibitors in human serum and synovial fluid. II. Mitogenic stimulation, interleukin 2 production and interleukin 2 receptor expression in rheumatoid arthritis, psoriatic arthritis and Reiter's syndrome.
abstract: Peripheral blood and synovial fluid (SF) mononuclear cells from 30 patients with rheumatoid arthritis (RA) were hyporesponsive to mitogenic stimulation with plant lectins and CD3 antibodies, due to depressed interleukin 2 (IL-2) production and IL-2 receptor upregulation. In contrast, in the seronegative arthritis patient group only SF mononuclear cells were hyporesponsive to mitogenic stimulation and there were no significant differences in IL-2 production or IL-2 receptor upregulation as compared with control subjects. No significant correlations were observed between IL-2 inhibitor levels and mitogenic responses, IL-2 production and IL-2 receptor upregulation on peripheral blood and SF mononuclear cells but an inverse correlation was noted between SF mitogenic responses and the expression of selected activation markers. We conclude that IL-2 abnormalities appear to be most pronounced in RA compared with other inflammatory arthritides and that these changes do not appear to be directly related to serum or SF IL-2 inhibitor levels.
authors: Department of Clinical Immunology, Flinders Medical Centre, Adelaide, South Australia.
authors: M D
authors: MD
authors: Smith
authors: P J
authors: PJ
authors: Roberts-Thomson
mesh_terms: D001168:Arthritis / Q000097:blood / Q000378:metabolism; D016918:Arthritis, Reactive / Q000097:blood / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000378:metabolism; D001773:Blood Cells / Q000378:metabolism; D006801:Humans; D007376:Interleukin-2 / Q000037:antagonists & inhibitors / Q000097:blood* / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D008934:Mitogens / Q000494:pharmacology*; D009000:Monocytes / Q000378:metabolism; D011565:Psoriasis / Q000097:blood / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D012216:Rheumatic Diseases / Q000097:blood / Q000378:metabolism*; D013582:Synovial Fluid / Q000166:cytology / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism
chemical_list: D007376:Interleukin-2; D008934:Mitogens; D015375:Receptors, Interleukin-2; D013936:Thymidine