Immunogenetic analysis of spontaneous autoimmune thyroiditis of obese strain chickens.
A variety of immunological, endocrinological, and virological abnormalities have been implicated in the etiopathogenesis of spontaneous autoimmune thyroiditis (SAT) of Obese strain (OS) chickens, e.g., a general T cell hyperreactivity, an increased uptake of iodine into the thyroid gland, a diminution of the glucocorticoid tonus, and an OS-specific endogenous virus. In crosses of the close-bred OS B15/B15 subline with the inbred normal CB B12/B12 strain we have studied the mode of inheritance of these aberrations and their putative association with SAT. The results indicate that none of these OS-specific characteristics alone is an absolute prerequisite for the development of thyroid infiltration, which appears to be governed by one autosomal recessive gene.
Kroemer
G
G
Institute for General and Experimental Pathology, University of Innsbruck, Medical School, Austria.
Neu
N
N
Kuehr
T
T
Dietrich
H
H
Fässler
R
R
Hala
K
K
Wick
G
G
D000818:Animals; D002645:Chickens; D003433:Crosses, Genetic; D007455:Iodine / Q000493:pharmacokinetics; D008285:Major Histocompatibility Complex; D009765:Obesity / Q000235:genetics* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013961:Thyroid Gland / Q000378:metabolism / Q000473:pathology; D013967:Thyroiditis, Autoimmune / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D014156:Transcortin / Q000032:analysis
D014156:Transcortin; D007455:Iodine