title: Effect of rokitamycin on human polymorphonuclear leukocyte chemotaxis.
abstract: The effect of rokitamycin on human polymorphonuclear leukocyte (PMNL) chemotaxis was studied in vitro and in vivo. It was found that rokitamycin in vitro at a concentration of 20 micrograms/ml caused a diminution of PMNL migration, while at lower concentrations no significant effects on migration was observed. In in-vivo studies before and after the ingestion of rokitamycin by six healthy individuals, no change on PMNL chemotaxis was found.
authors: Division of Infectious Diseases, Regional Hospital, Varese, Italy.
authors: D
authors: D
authors: Torre
authors: M
authors: M
authors: Broggini
authors: S
authors: S
authors: Rossi
authors: C
authors: C
authors: Sampietro
authors: V
authors: V
authors: Bottà
mesh_terms: D000328:Adult; D002465:Cell Movement / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D015644:Miocamycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects
chemical_list: D015644:Miocamycin; C033383:rokitamycin