Synthesis and in vitro activity of new semi-synthetic coumermycin analogs: chemical modification at the C-3 amide.
Several new semi-synthetic coumermycin analogs, which carry a polar substituent at the C-3 amide moiety have been prepared. In vitro antibacterial activity of these new analogs against Gram-positive organisms, particularly methicillin-resistant strains of Staphylococci species has been described.
Ueda
Y
Y
Antiinfective Chemistry Department, Bristol-Myers Company, Wallingford, CT 06492.
Chuang
J M
JM
Crast
L B
LB
Partyka
R A
RA
D049933:Aminocoumarins; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003374:Coumarins / Q000138:chemical synthesis / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D049933:Aminocoumarins; D000900:Anti-Bacterial Agents; D003374:Coumarins; C004628:coumermycin