title: The amino acid sequence of rabbit skeletal muscle glycogenin.
abstract: The amino acid sequence of glycogenin from rabbit skeletal muscle has been determined. The N-acetylated protein consists of 332 amino acids and has a molecular mass of 37278 Da. The novel tyrosyl-glucose linkage between glycogenin and glycogen [Smythe, C., Caudwell, F. B., Ferguson, M. & Cohen, P. (1988) EMBO J. 7, 2681-2686] is shown to occur at a single site, tyrosine-194. Although glycogenin is a UDP-Glc utilising glucosyltransferase that self-glucosylates [Pitcher, J., Smythe, C. & Cohen, P. (1988) Eur. J. Biochem. 176, 391-395], following addition by an unknown enzyme of the first glucose to tyrosine-194, it is not homologous to either human glycogen synthase or other UDP-Glc-requiring enzymes.
authors: Department of Biochemistry, University of Dundee, Scotland, UK.
authors: D G
authors: DG
authors: Campbell
authors: P
authors: P
authors: Cohen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005964:Glucosyltransferases; D006023:Glycoproteins / Q000032:analysis*; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000032:analysis*; D010766:Phosphorylation; D011487:Protein Conformation; D011817:Rabbits
chemical_list: D006023:Glycoproteins; D009124:Muscle Proteins; C051887:glycogenin; D005964:Glucosyltransferases