Antiestrogen antibodies, oral contraception and systemic lupus erythematosus.
Oral contraceptives (OC) are suspect to play a role in systemic lupus erythematosus (SLE). It has previously been shown that OC can induce immune reactions in a number of normal women. Antiethinylestradiol antibodies (anti-EE Ab) have been detected with a radioimmunoassay method in 25-30% of healthy OC users. In the present paper, a comparative study of 123 controls and 55 SLE patients, with or without OC use, indicates (1) that in the disease-free group, anti-EE Ab were detected in 30% of OC users, and only in OC users; (2) that in the SLE group, anti-EE Ab were observed in 57% of female OC users, and, surprisingly, in 13% of men also, a finding already reported by other authors.
Beaumont
V
V
Inserm U-32, Department of Cardiology, Hôpital Herni-Mondor, Créteil, France.
Gioud-Paquet
M
M
Kahn
M F
MF
Beaumont
J L
JL
D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000032:analysis*; D003276:Contraceptives, Oral / Q000009:adverse effects*; D004997:Ethinyl Estradiol / Q000276:immunology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced / Q000209:etiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D000906:Antibodies; D003276:Contraceptives, Oral; D004997:Ethinyl Estradiol