title: Novel poly-substituted aryl acridinium esters and their use in immunoassay.
abstract: A new series of stable acridinium ester conjugates have been developed for use as non-isotopic labels in immunoassay. They have proved to be a flexible alternative to radioimmunoassay. We present data showing the successful development of immunoassays in sandwich, competitive and receptor formats. In addition, hydrophilic acridinium ester analogues have been synthesized, encapsulated in liposomes, and utilized as labels in immunoassay. The potential of this technology is discussed.
authors: Ciba-Corning Diagnostics, E. Walpole, MA 02032.
authors: S J
authors: SJ
authors: Law
authors: T
authors: T
authors: Miller
authors: U
authors: U
authors: Piran
authors: C
authors: C
authors: Klukas
authors: S
authors: S
authors: Chang
authors: J
authors: J
authors: Unger
mesh_terms: D000166:Acridines; D004952:Esters; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D008081:Liposomes; D008163:Luminescent Measurements; D011863:Radioimmunoassay; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D000166:Acridines; D004952:Esters; D008081:Liposomes; D013972:Thyrotropin; D014805:Vitamin B 12; D013974:Thyroxine