Allopurinol inhibits uric acid accumulation in the rat brain following focal cerebral ischemia.
Uric acid (UA) in the rat brain was measured by HPLC with an electrochemical detector following focal ischemia. At 24 h after the operation, the UA level in the ischemic center was 105.47 +/- 8.39 nmol/g tissue, whereas it was 8.36 +/- 1.86 in the sham-operated group. Allopurinol, xanthine oxidase inhibitor, almost completely inhibited this UA accumulation. These data demonstrate that the UA increase in the ischemic brain is due to the xanthine oxidase reaction.
Kanemitsu
H
H
Department of Neurosurgery, Teikyo University School of Medicine, Tokyo, Japan.
Tamura
A
A
Kirino
T
T
Oka
H
H
Sano
K
K
Iwamoto
T
T
Yoshiura
M
M
Iriyama
K
K
D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014527:Uric Acid / Q000378:metabolism*
D014527:Uric Acid; D000493:Allopurinol