[Inhibiting effect of the polyphenolic complex from Plantago major (plantastine) on the carcinogenic effect of endogenously synthesized nitrosodimethylamine].
Amidopyrine administered in combination with sodium nitrite in the long-term experiment produces the toxic damage of the liver and tumors in rats in connection with endogenic synthesis of carcinogenic nitrosodimethylamine. The inclusion into the animal diet of the polyphenolic complex from Plantago major--plantastine as an inhibitor of the carcinogen synthesis reduced the toxic damage of the liver that was indicated by normalization of biochemical parameters and also decreased the tumor yield from 87.5% to 33.3%. The data obtained may be the basis for the combined use of plantastine with nitrosated drugs that would contribute to carcinogenesis prevention.
Karpilovskaia
E D
ED
Gorban'
G P
GP
Pliss
M B
MB
Zakharenko
L N
LN
Gulich
M P
MP
D000632:Aminopyrine / Q000633:toxicity; D000818:Animals; D002273:Carcinogens; D055598:Chemical Phenomena; D002621:Chemistry; D004008:Diclofenac / Q000493:pharmacokinetics* / Q000494:pharmacology; D004128:Dimethylnitrosamine / Q000378:metabolism* / Q000633:toxicity; D008297:Male; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D010943:Plantago / Q000032:analysis*; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D012977:Sodium Nitrite / Q000633:toxicity
D002273:Carcinogens; D010636:Phenols; D010936:Plant Extracts; D000632:Aminopyrine; D004008:Diclofenac; D012977:Sodium Nitrite; D004128:Dimethylnitrosamine
Ingibiruiushchee vliianie polifenol'nogo kompleksa iz podorozhnika bol'shogo--plantastina--na kantserogennyĭ éffekt éndogenno sintezirovannogo nitrozodimetilamina.