Drug-induced anticentromere antibody?
Anticentromere antibody (ACA) was previously described as a serological marker for CREST, progressive systemic sclerosis (PSS), Raynaud's syndrome (RS) and primary biliary cirrhosis (PBC). We have observed ACA appearing and disappearing during D-penicillamine (DPA) treatment in six patients without any features of CREST, PSS, RS, PBC or related syndromes. ACA also could be DPA-induced.
Haberhauer
G
G
Second Department of Internal Medicine, Kaiser-Franz-Josef-Hospital, Vienna, Austria.
Bröll
H
H
D000974:Antibodies, Antinuclear / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D002503:Centromere / Q000276:immunology*; D002875:Chromosomes / Q000276:immunology*; D004247:DNA / Q000276:immunology; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy / Q000276:immunology*; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use; D012217:Rheumatoid Factor / Q000032:analysis
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D004247:DNA; D012217:Rheumatoid Factor; D010396:Penicillamine