Susceptibility of methicillin-resistant Staphylococcus aureus to the selenium-containing compound 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ51).
The growth of Staphylococcus aureus 209P was inhibited by 0.20 micrograms of 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ51) per ml, while strains of the family Enterobacteriaceae were more resistant to the drug. The MIC for 90% of methicillin-resistant S. aureus strains was 1.56 micrograms/ml, and the drug was bactericidal. The selenium in PZ51 was essential, since its sulfur analog (PZ25) lost the antibacterial activity.
Nozawa
R
R
Laboratory for Microbiology, School of Food and Nutritional Sciences, University of Shizuoka, Japan.
Yokota
T
T
Fujimoto
T
T
D001393:Azoles / Q000494:pharmacology*; D054833:Isoindoles; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D016566:Organoselenium Compounds; D010403:Penicillin Resistance; D012643:Selenium / Q000378:metabolism / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
D001393:Azoles; D054833:Isoindoles; D016566:Organoselenium Compounds; C042986:ebselen; D012643:Selenium; D008712:Methicillin