title: Renal and extrarenal use of glutamine in normal and acidotic dogs.
abstract: The total body clearance of glutamine in five normal and four acidotic dogs was estimated from the kinetics of disappearance from the blood of 14C-[U]-L-glutamine administered in a central vein as a single bolus. The disappearance curve was analyzed as reflecting a biexponential phenomenon with both a mixing and a metabolism component occurring, respectively, in the extracellular (mixing) and intracellular compartment (metabolism). The apparent total body metabolism of glutamine (total body clearance x arterial concentration) was compared with the renal use of this aminoacid as directly determined by renal A-V differences and blood flow. It was demonstrated that the renal use of glutamine represents between 13% and 25% of the total body use, and was increased by acidosis, which did not change significantly the overall rate of synthesis or use.
authors: Nephrology Service, Hôpital Notre-Dame, Montréal, Québec, Canada.
authors: P
authors: P
authors: Vinay
authors: M
authors: M
authors: Soowamber
authors: P R
authors: PR
authors: De Cotret
authors: A
authors: A
authors: Gougoux
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000097:blood / Q000378:metabolism*; D000818:Animals; D004285:Dogs; D005973:Glutamine / Q000097:blood / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics
chemical_list: D005973:Glutamine