[Interrelations between genetically determined haptoglobin types and the course of the postoperative period in chronic forms of pulmonary tuberculosis].
Haptoglobin (Hp) phenotyping was performed in 346 patients with chronic tuberculosis of the lungs. 135 of them had been earlier subjected to operations which turned to be inefficient by various reasons. Among the patients with chronic destructive and complicated tuberculosis of the lung the number of the persons with Hp 2-1 lowered to 38.7 +/- 2.6 per cent (against 53.5 +/- 5.0 per cent in the reference group) while the number of the persons with Hp 2-2 increased (47.1 +/- 2.7 per cent). During the observation period 193 patients were operated. Within the immediate postoperative period various complications developed in 28.2 +/- 5.3 per cent of the patients with Hp 2-1, in 43.7 +/- 8.8 per cent of the patients with Hp 1-1 and in 47.8 +/- 5.3 per cent of the patients with Hp 2-2. The patients with Hp 1-1 by their histories and postoperative time courses were characterized by susceptibility to relapses and aggravation of the specific process during therapy. The therapy performed was insufficient beneficial for patients with Hp 2-2. It was concluded that homozygous variants of Hp were additional risk factors in phthisiosurgical patients.
Kaminskaia
G O
GO
Zhukova
N L
NL
Naumov
V N
VN
D000328:Adult; D005260:Female; D006242:Haptoglobins / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D010641:Phenotype; D011183:Postoperative Complications / Q000209:etiology*; D012008:Recurrence; D014397:Tuberculosis, Pulmonary / Q000235:genetics* / Q000601:surgery
D006242:Haptoglobins
Vzaimosviaz' geneticheski determinirovannykh tipov gaptoglobina s techeniem posleoperatsionnogo perioda pri khronicheskikh formakh tuberkuleza legkikh.