title: [Stimulatory effects of small doses of mutagens].
abstract: Small radiation doses stimulate the organism. This so-called hormetic effect was first described in the fifties, however, only in recent years it has been accepted. According to data in the literature the hormetic effect comprises stimulation of the immune system, a general increase of the resistance of the organism, a reduced risk of cancer and in model organisms a protraction of the median life span was observed. Positive effects of small doses were observed in experiments with cell and tissue cultures of animal and plant origin. A prolongation of the median and maximal life span in Drosophilae was also observed. There are indications that the hormetic effect could be due to the action of chemical mutagens. Attempts to explain this phenomenon are as a rule based on the finding that the activity of reparative DNA systems is substantially increased in case of a disorder of newly synthetized DNA. This reduction is triggered by a feedback reaction in the regulatory chain of synthesis of reparative enzymes. In the literature experiments were already described on the application of the hormetic phenomenon in therapy. Wider use calls, however, for systematic research. The perspective seem promising.
authors: S
authors: S
authors: Doubal
authors: J
authors: J
authors: Horsky
mesh_terms: D000818:Animals; D004330:Drosophila; D006801:Humans; D007109:Immunity / Q000187:drug effects* / Q000528:radiation effects; D007114:Immunization; D009153:Mutagens / Q000008:administration & dosage* / Q000494:pharmacology; D011829:Radiation Dosage
chemical_list: D009153:Mutagens
vernacular_title: Stimulacni úcinky malých dávek mutagenů na organismus.