Detection of high levels of immunoreactive human beta-1 interferon in sera from HIV-infected patients.
We have examined human interferon beta-1 (HuIFN-beta 1) levels in the sera from patients with various diseases by using a newly developed highly sensitive enzyme-linked immunosorbent assay system (ELISA). High levels of HuIFN-beta 1 were detected in the sera from Human Immunodeficiency Virus-I (HIV-I) infected patients, especially of asymptomatic carriers. The serum level of HuIFN-beta 1 may be a good indicator of HIV-I infection and of other immunological disorders.
Minagawa
T
T
Department of Microbiology, Hokkaido University School of Medicine, Sapporo, Japan.
Mizuno
K
K
Hirano
S
S
Asano
M
M
Numata
A
A
Kohanawa
M
M
Nakane
A
A
Hachimori
K
K
Tamagawa
S
S
Negishi
M
M
D000386:AIDS-Related Complex / Q000097:blood; D000911:Antibodies, Monoclonal; D004797:Enzyme-Linked Immunosorbent Assay; D015658:HIV Infections / Q000097:blood* / Q000150:complications; D006679:HIV Seropositivity / Q000097:blood; D006509:Hepatitis B / Q000097:blood / Q000150:complications; D006801:Humans; D007370:Interferon Type I / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications; D010391:Pemphigoid, Bullous / Q000097:blood / Q000150:complications
D000911:Antibodies, Monoclonal; D007370:Interferon Type I