[The induction of latent liver damage by cyclophosphamide].
The effect of the cyclophosphamide on the changes of the mitotic index (MI), metaphase-prophase ratio (M/P) and chromosomal aberrations in postmetaphase in regenerating rat liver was studied. Cyclophosphamide was injected in the single doses of 100 and 200 mg/kg i.p. 2 hours before partial hepatectomy (PHE). The results have shown that cyclophosphamide caused latent liver damage which was manifested after PHE in reduced MI and increased frequency of chromosomal aberrations. The extent of the changes induced by cyclophosphamide corresponds to that due to the effect of 3 or 6 Gy of X-rays, respectively.
Kropacová
K
K
Misurová
E
E
D000818:Animals; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006498:Hepatectomy; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008115:Liver Regeneration / Q000187:drug effects; D008297:Male; D008938:Mitosis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003520:Cyclophosphamide
Induktsiia latentnogo povrezhdeniia pecheni tsiklofosfamidom.