[Comparative effect of apalcillin and other beta-lactam antibiotics against the Bacteroides fragilis group].
The in vitro activity of apalcillin was compared with those of mezlocillin, piperacillin, cefoxitin, cefotaxime and cefotetan against 50 strains of Bacteroides fragilis group. The minimal concentrations were determined by a microdilution method in Wilkins-Chalgren medium and subculturing on agar. On the basis of MICs and MBCs range, the activity of apalcillin was similar to that of other beta-lactam antibiotics; cefoxitin was slightly more active. The mode MICs were as follow: apalcillin = 16 micrograms/ml, mezlocillin = 8 micrograms/ml, piperacillin = 2 micrograms/ml, cefoxitin = 8 micrograms/ml, cefotaxime = 8 and 32 micrograms/ml, cefotetan = 4 micrograms/ml. All the strains of B. thetaiotaomicron and B. vulgatus were susceptible to the six beta lactam compounds. The MBCs and MICs were similar. Apalcillin had the greatest bactericidal activity.
Dusart
G
G
Laboratoire de Bactériologie, Faculté de Pharmacie, Montpellier.
Simeon de Buochberg
M
M
Zuccarelli
M
M
Attisso
M A
MA
Willemin
C
C
D000667:Ampicillin / Q000031:analogs & derivatives / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001441:Bacteroides fragilis / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines
D000900:Anti-Bacterial Agents; D009287:Naphthyridines; C012122:apalcillin; D000667:Ampicillin
Activité comparée de l'apalcilline à celle d'autres bêtalactamines vis-à-vis de Bacteroides du groupe fragilis.