title: Effect of strain differences on the potency testing of rabies vaccines in mice.
abstract: Antigenic differences between several strains of rabies virus, namely CVS, SAD and Flury (LEP) strains, were studied in cross-challenge experiments or cross-neutralization tests performed on sera of mice immunized with vaccines containing each strain. A typical wild fox virus strain was also included as challenge virus. The strain differences affected the relative potencies of the three vaccines in the European Pharmacopoeia mouse protection test for veterinary rabies vaccines, in that higher antigenic values were obtained when the vaccine strain was homologous to the challenge virus. This observation was confirmed by neutralizing antibody induction in mice.
authors: Centre National d'Etudes Vétérinaires et Alimentaires, Laboratoire d'Etudes sur la Rage et la Pathologie, Malzéville, France.
authors: J
authors: J
authors: Blancou
authors: M F
authors: MF
authors: Aubert
authors: E
authors: E
authors: Cain
authors: M
authors: M
authors: Selve
authors: O
authors: O
authors: Thraenhart
authors: L
authors: L
authors: Bruckner
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D004797:Enzyme-Linked Immunosorbent Assay; D051379:Mice; D011819:Rabies Vaccines / Q000276:immunology* / Q000592:standards; D011820:Rabies virus / Q000276:immunology*; D013045:Species Specificity; D014944:World Health Organization
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines