title: Controlled dosage titration of febantel paste in naturally parasitized cattle.
abstract: A controlled anthelmintic trial was conducted to determine the efficacy of febantel paste (45.5%) at dosages of 2.5, 5.0, 7.5, and 10.0 mg/kg in calves harboring natural gastrointestinal nematode infections. Dosages of 5.0, 7.5 and 10.0 mg of febantel/kg of body weight were greater than 96% effective in removing adults of Haemonchus contortus, Ostertagia spp, Cooperia spp, and Oesophagostomum radiatum. The 2.5 mg/kg dosage was considered suboptimal because of low efficacy against Ostertagia and Cooperia spp. Efficacies against Trichostronglylus axei, Trichuris spp, Bunostomum phlebotomum, and Stronglyloides papillosus were difficult to determine because fewer numbers of these nematodes were recovered. Efficacies of febantel paste against immature bovine parasites ranged from 83.62% to 97.72%.
authors: Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849-5519.
authors: B L
authors: BL
authors: Blagburn
authors: C M
authors: CM
authors: Hendrix
authors: L A
authors: LA
authors: Hanrahan
authors: D S
authors: DS
authors: Lindsay
authors: R G
authors: RG
authors: Arther
authors: J W
authors: JW
authors: Drane
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000627:therapeutic use; D001835:Body Weight; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000469:parasitology; D005260:Female; D006146:Guanidines / Q000008:administration & dosage* / Q000627:therapeutic use; D006189:Haemonchus / Q000187:drug effects; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D007814:Larva / Q000187:drug effects; D008297:Male; D009349:Nematode Infections / Q000469:parasitology / Q000662:veterinary*; D009815:Oesophagostomum / Q000187:drug effects; D010028:Ostertagia / Q000187:drug effects
chemical_list: D000871:Anthelmintics; D006146:Guanidines; C017309:febantel