Spectrum and outcome of microbiologically documented listeria monocytogenes infections in cancer patients.
At the M.D. Anderson Cancer Center (Houston), Listeria monocytogenes was cultured from 14 patients between 1980 and 1987. The case records of 11 of these patients were reviewed. Underlying malignancies included acute leukemia (three), lymphoma (two), myeloma (one), adenocarcinoma of colon (two), carcinoma of breast (one), carcinoma of lung (one), and Kaposi's sarcoma associated with the acquired immune deficiency syndrome (one). Listeria monocytogenes was cultured from blood (eight patients), cerebrospinal fluid (CSF) (two patients), and from both blood and CSF in one patient. All patients were receiving immunosuppressive therapy including corticosteroids in seven. An absolute neutrophil count of less than 1000/mm3 was noted in five. Bacteremia was the predominant type of infection and ten patients responded to antimicrobial therapy.
Khardori
N
N
Department of Medical Specialities, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Berkey
P
P
Hayat
S
S
Rosenbaum
B
B
Bodey
G P
GP
D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008088:Listeriosis / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D008297:Male; D008584:Meningitis, Listeria / Q000150:complications; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014640:Vancomycin / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D014640:Vancomycin; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination