title: Increased plasma tricyclic antidepressant concentrations in two patients concurrently treated with fluoxetine.
abstract: Two patients taking stable doses of standard tricyclic antidepressants were additionally treated with fluoxetine as the first step in a transition to that drug. After fluoxetine was added, both patients' plasma tricyclic antidepressant levels increased substantially. Adverse side effects occurred in one patient. Fluoxetine may increase the plasma levels of standard tricyclic antidepressants and the likelihood of tricyclic antidepressant toxicity.
authors: Department of Psychiatry, University of Tennessee, Memphis College of Medicine, TN 38105.
authors: J M
authors: JM
authors: Downs
authors: A D
authors: AD
authors: Downs
authors: T L
authors: TL
authors: Rosenthal
authors: N
authors: N
authors: Deal
authors: H S
authors: HS
authors: Akiskal
mesh_terms: D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans
chemical_list: D000929:Antidepressive Agents, Tricyclic; D005473:Fluoxetine