Synthesis of cyclic oligodeoxyribonucleotides via the 'filtration' approach.
The synthesis of cyclic di-, tri-, tetra-, penta- and hexa-thymidylic acids (16; n = 2, 3, 4, 5 and 6) and the cyclic hexadeoxyribonucleotide [d(CpCpTpApGpGp)], via the "filtration" approach, is reported. Some of the physical properties of the cyclic oligonucleotides are discussed, and their susceptibility to digestion in the presence of phosphorylytic enzymes has been studied.
Rao
M V
MV
Department of Chemistry, King's College London, Strand, UK.
Reese
C B
CB
D001483:Base Sequence; D002853:Chromatography, Liquid; D003460:Crystallization; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000302:isolation & purification
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides