title: Anti-inflammation induced by counter-irritation or by treatment with non-steroidal agents inhibits the growth of a tumour of non-detected immunogenicity.
abstract: Counter-irritation (CI) triggered by different non-specific irritant stimuli delayed the growth of a murine tumour of non-detected immunogenicity. The syngeneic LB tumour transplant by itself also induced CI and decreased the number of leukocytes migrating to a secondary s.c. irritant stimulus, e.g. sponge or carrageenan. On the other hand, partial inhibition of cell migration by treatment with either 0.5 mg kg-1 indomethacin or 0.3 mg kg-1 piroxicam retarded LB tumour growth, presumably by a mechanism unrelated to inhibition of immune responses by PGE2. It is suggested that CI may play a role in the early stages of concomitant resistance.
authors: Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
authors: D O
authors: DO
authors: Sordelli
authors: P A
authors: PA
authors: Fontán
authors: R P
authors: RP
authors: Meiss
authors: R A
authors: RA
authors: Ruggiero
authors: O D
authors: OD
authors: Bustuoabad
mesh_terms: D000818:Animals; D005260:Female; D007213:Indomethacin / Q000627:therapeutic use*; D007509:Irritants; D015458:Leukemia, T-Cell / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010894:Piroxicam / Q000627:therapeutic use*
chemical_list: D007509:Irritants; D010894:Piroxicam; D007213:Indomethacin