Studies of immunoglobulin and T cell receptor gene rearrangement in cutaneous B and T cell lymphomas.
We report two patients with cutaneous B and T cell lymphomas, respectively, in which DNA rearrangement studies were instrumental in establishing a diagnosis. In each case clinical, histopathologic, and immunologic criteria were not sufficient to establish a definitive tissue classification. The use of DNA gene rearrangement studies in the analysis of cutaneous lymphomas is discussed.
Liang
G
G
Department of Medicine, University of Miami School of Medicine, FL 33101.
Pardo
R J
RJ
Voigt
W
W
Gould
E W
EW
Falanga
V
V
D000368:Aged; D001402:B-Lymphocytes; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000175:diagnosis / Q000235:genetics*; D013601:T-Lymphocytes