[Heparin prophylaxis of thrombohemorrhagic complications in surgical interventions in cancer patients].
Patients with uterine (394), ovarian (272) and breast cancer (122) were followed postoperatively using complex clinico-biomicroscopic method. Control (no heparin) group 1 included 100 patients and control group 2 (prophylactic mini-doses of heparin pre- and postoperatively)--142. Intra- and postoperative heparin was administered for prevention of thrombohemorrhagic syndrome (THS) in a study group of 152 patients. Such complications as phlebothrombosis and bronchopneumonia occurred in 19% (control group 1), and phlebothrombosis--in 11.2% (control group 2), vascular bleeding--in 2 cases. Bleeding from open vessel was observed in 1 case of radical mastectomy (study group) and microhematuria--in 8 cases of uterine extirpation with the appendages. The study revealed chronic THS-type coagulation disturbances in uterine, ovarian and breast cancer patients as well as high effectiveness of prevention of their progression by intra- and postoperative heparin administration.
Nadiradze
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D001780:Blood Coagulation Tests; D001943:Breast Neoplasms / Q000601:surgery*; D005260:Female; D005833:Genital Neoplasms, Female / Q000601:surgery*; D006470:Hemorrhage / Q000517:prevention & control*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control*; D013927:Thrombosis / Q000517:prevention & control*
D006493:Heparin
Geparinoprofilaktika trombogemorragicheskikh oslozhneniĭ pri khirurgicheskikh vmeshatel'stvakh u onkologicheskikh bol'nykh.