Hepatic granulomata in long-term hemodialysis patients with hyperaluminumemia.
We describe two long-term hemodialysis patients with hyperaluminumemia, in whom multiple granulomata were found in the livers at autopsy. The granulomata were mainly composed of modified macrophages, and aluminum was constantly detected in the cytoplasm of these macrophages by histochemical analysis, as well as by X-ray microanalysis. These granulomata were also found in the spleen and lymph nodes. The constant presence of aluminum in the mononuclear phagocytic system might have been followed by the development of granulomata. Functional disturbances of the liver were not evident.
Kurumaya
H
H
Second Department of Pathology, School of Medicine, Kanazawa University, Japan.
Kono
N
N
Nakanuma
Y
Y
Tomoda
F
F
Takazakura
E
E
D000328:Adult; D000368:Aged; D000535:Aluminum / Q000032:analysis / Q000097:blood*; D004577:Electron Probe Microanalysis; D005260:Female; D006099:Granuloma / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008099:Liver / Q000032:analysis; D008107:Liver Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D006435:Renal Dialysis / Q000009:adverse effects*
D000535:Aluminum