Chromosomal analyses of human lymphocytes exposed in vitro to caprolactam.
Caprolactam was tested for the induction of chromosomal aberrations in cultured human lymphocytes from one male donor and one female donor. At 7.5 mg/ml, caprolactam-treated cells from the male showed a small but significant increase in the frequency of aberrations. No effect was observed in cells from the female if gaps are excluded.
Kristiansen
E
E
Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Withington, Manchester, Great Britain.
Scott
D
D
D000328:Adult; D001381:Azepines / Q000633:toxicity*; D002209:Caprolactam / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008677:Metaphase / Q000187:drug effects; D009153:Mutagens
D001381:Azepines; D009153:Mutagens; D002209:Caprolactam