Topical corticosteroid compounding: effects on physicochemical stability and skin penetration rate.
Compounding compatibility studies of four corticosteroid cream products and four commonly added chemicals are presented. Physical alteration, chemical stability, micropreservative challenge status, and in vitro skin penetration were evaluated at ambient conditions for 2 months. The study was designed to generate useful, previously unavailable information to aid dispensing pharmacists and dermatologists.
Krochmal
L
L
Pharmaceutical Research and Development Division, Bristol-Myers Co., Buffalo, New York.
Wang
J C
JC
Patel
B
B
Rodgers
J
J
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics*; D055598:Chemical Phenomena; D002621:Chemistry; D003899:Desoximetasone / Q000493:pharmacokinetics; D004339:Drug Compounding; D005447:Fluocinonide / Q000493:pharmacokinetics; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D012869:Skin Absorption / Q000502:physiology*; D014222:Triamcinolone Acetonide / Q000493:pharmacokinetics
D000893:Anti-Inflammatory Agents; D005447:Fluocinonide; D003899:Desoximetasone; C038363:hydrocortisone valerate; D014222:Triamcinolone Acetonide; D006854:Hydrocortisone