Urinary interleukin-2 inhibition in patients with cystitis.
An inhibitor of interleukin-2 activity (IL-2-IN) is present in the urine of most patients during the acute phase of untreated bacterial cystitis (UTI). We measured urinary IL-2-IN activity in 30 adults with uncomplicated UTIs and followed the patients for an additional 6 months. Urinary IL-2-IN activity ranged between 0 and 1.97 units/mg urine creatinine (U/mg u.c.). Relatively low levels of IL-2-IN (less than 0.5 U/mg u.c.) correlated with a prior history of recurrent UTIs (p less than 0.01), and also were predictive of a subsequent UTI during the 6 month follow-up, regardless of the prior medical history (p less than 0.01). Measurement of urinary IL-2-IN during the untreated phase of a UTI may prove helpful for directing antibiotic prophylaxis against subsequent UTIs.
Fleischmann
J D
JD
Department of Surgery (Urology) Case Western Reserve University, Cleveland, Ohio 44109.
Wentworth
D B
DB
Thomas
K M
KM
Imbembo
A L
AL
D001424:Bacterial Infections / Q000150:complications; D002478:Cells, Cultured; D003556:Cystitis / Q000652:urine*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007376:Interleukin-2 / Q000037:antagonists & inhibitors; D008222:Lymphokines / Q000652:urine*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology
D007376:Interleukin-2; D008222:Lymphokines; C046147:interleukin 2 inhibitor