Isoflurane inhibits enflurane metabolism in man.
Halogenated inhalation anaesthetics interfere with each other's hepatic microsomal metabolism. The increase in plasma inorganic fluoride concentration, caused by the metabolism of a standardised dose of enflurane, was attenuated by isoflurane given either before or after the enflurane exposure. It is concluded that isoflurane inhibits the metabolism of enflurane in man, a fact that might be advantageous in certain clinical situations.
Oikkonen
M P
MP
Department of Anaesthesia, Otolaryngological Hospital, Helsinki University Central Hospital, Finland.
D000328:Adult; D000769:Anesthesia, Inhalation; D004737:Enflurane / Q000378:metabolism*; D005260:Female; D005459:Fluorides / Q000097:blood; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male
D004737:Enflurane; D007530:Isoflurane; D005459:Fluorides