title: Two species of the phosphoprotein mRNA with differently edited reading frames discovered in measles virus infected Vero cells. Brief report.
abstract: One cDNA clone representing the phosphoprotein mRNA sequence of the Edmonston strain of measles virus contained 4 G nucleotides at a particular position. Two other clones contained 3 G nucleotides at the same position. Otherwise the nucleotide sequence were identical. The mRNA with 3 G nucleotides codes for the 70 kD phosphoprotein. The mRNA with 4 G nucleotides may code for a putative new peptide with 231 aminoterminal amino acids in common with the P protein whereas the 68 carboxyterminal amino acids are different from any amino acid sequence of the phosphoprotein. Thus the consequence of the insertion of one additional G is a translational shift to a shorter open reading frame. There are several indications that the observation is of biological significance.
authors: Department of Microbiology and Immunology, Gade Institute, Bergen, Norway.
authors: K H
authors: KH
authors: Kalland
authors: L S
authors: LS
authors: Havarstein
authors: C
authors: C
authors: Endresen
authors: G
authors: G
authors: Haukenes
mesh_terms: D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005807:Genes, Overlapping; D008459:Measles virus / Q000235:genetics*; D010750:Phosphoproteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D014709:Vero Cells
chemical_list: D010750:Phosphoproteins; D012333:RNA, Messenger; D004247:DNA