Behavioral characteristics of the SAM-P/8 strain in Sidman active avoidance task.
The behavior of the senescence-accelerated mouse (SAM-P/8) at the age of 1, 2, 4 and 10-11 months in Sidman active avoidance learning was analyzed, and compared to findings in the controls (SAM-R/1). At the age of 1 and 2 months, learning was comparable in these two strains. At the age of 4 and 10-11 months, SAM-P/8 but not SAM-R/1 learned active avoidance. We propose that SAM-P/8 can serve as a valid model of deficits in learning and memory.
Ohta
A
A
Department of Psychology, Faculty of Letters, Kyoto University, Japan.
Hirano
T
T
Yagi
H
H
Tanaka
S
S
Hosokawa
M
M
Takeda
T
T
D000375:Aging / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D008297:Male; D051379:Mice