title: Human chorionic gonadotropin in colorectal cancer and its relationship to prognosis.
abstract: The presence of human chorionic gonadotropin in large bowel cancers was studied immunohistochemically using an immunoperoxidase technique. HCG-positive tumour cells were present in 42 of 194 adenocarcinomas examined (22.0% of colon cancer and 21.2% of rectal cancers). On histological grading, the hCG-positive rate tended to rise as the degree of differentiation decreased. HCG was detected more frequently in cancers invading the total bowel wall (27%) than in those invading the partial wall (17.1%). Lymph node, liver or peritoneal metastases were present more frequently in hCG-positive tumours than in hCG-negative tumours. Furthermore, there was an intimate correlation between the presence of hCG-positive tumour cells and CEA doubling times in nine cases with untreated liver metastasis. The survival rate for patients with tissue hCG-positive cells was lower than for those with hCG-negative tumours. Thus, the presence of tissue hCG in colorectal cancers may be a biological marker of prognostic significance.
authors: Department of Surgery II, School of Medicine, Kanazawa University, Japan.
authors: A
authors: A
authors: Yamaguchi
authors: T
authors: T
authors: Ishida
authors: G
authors: G
authors: Nishimura
authors: T
authors: T
authors: Kumaki
authors: M
authors: M
authors: Katoh
authors: T
authors: T
authors: Kosaka
authors: Y
authors: Y
authors: Yonemura
authors: I
authors: I
authors: Miyazaki
mesh_terms: D000230:Adenocarcinoma / Q000032:analysis* / Q000473:pathology; D006063:Chorionic Gonadotropin / Q000032:analysis*; D003110:Colonic Neoplasms / Q000032:analysis* / Q000473:pathology; D006801:Humans; D011379:Prognosis; D012004:Rectal Neoplasms / Q000032:analysis* / Q000473:pathology
chemical_list: D006063:Chorionic Gonadotropin