The human homolog of the Moloney leukemia virus integration 2 locus (MLV12) maps to band p14 of chromosome 5.
The Moloney leukemia virus integration 2 (MLV12) locus represents a common region for proviral integration and a putative oncogene involved in the induction of thymic lymphomas in rodents. The human homolog of the MLV12 locus has been cloned and studies have been initiated to determine its possible role in the induction and progression of human neoplasms. In this study we used a panel of human X rodent somatic cell hybrids and in situ hybridization to metaphase chromosomes to map MLV12 to the short arm of the human chromosome 5, band p14.
Anagnou
N P
NP
Department of Basic Sciences, University of Crete School of Medicine, Greece.
Economou-Pachnis
A
A
O'Brien
S J
SJ
Modi
W S
WS
Nienhuis
A W
AW
Tsichlis
P N
PN
D000818:Animals; D001287:Attachment Sites, Microbiological; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D003001:Cloning, Molecular; D006801:Humans; D006822:Hybrid Cells; D008242:Lysogeny; D051379:Mice; D008979:Moloney murine leukemia virus / Q000235:genetics*; D009857:Oncogenes