title: Protective value of a liver initiation-promotion regimen against the lethal effect of carbon tetrachloride in rats.
abstract: This study was designed as one test of the hypothesis that an early sequence of steps in hepatocarcinogenesis in the rat, with the production of hepatocyte nodules, may be a special form of adaptive response that has survival value for the host. Fischer 344 rats were initiated with a single dose of diethylnitrosamine. Hepatocyte nodules were rapidly generated by selecting for resistant hepatocytes by a brief exposure to 2-acetylaminofluorene coupled with partial hepatectomy, a procedure that leads to liver cancer without any further treatment. Most animals with hepatocyte nodules were completely resistant to single doses of CCl4 that induced 100% mortality in control animals. The demonstration of this protective effect is consistent with the proposed hypothesis.
authors: Department of Pathology, University of Toronto, Ontario, Canada.
authors: L
authors: L
authors: Harris
authors: L E
authors: LE
authors: Morris
authors: E
authors: E
authors: Farber
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008113:Liver Neoplasms / Q000209:etiology / Q000401:mortality / Q000517:prevention & control; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D002251:Carbon Tetrachloride