Beneficial effects of anti-growth hormone antiserum in avian muscular dystrophy.
Human subjects and mice have been found to have a milder progression of muscular dystrophy when the disease is associated with genotypically determined dwarfism. In this paper we describe an experimental test for reducing growth hormone in dystrophic chickens that uses rabbit anti-chicken growth hormone anti-serum (anti-cGH). Antiserum was injected daily into dystrophic (line 413) male chickens from day 1 to day 8 after hatching. Dystrophic chickens injected with anti-cGH maintained a significantly higher score in the standardized test for righting ability (P less than 0.001-0.051) from 3 to 9 1/2 wk after hatching when compared with dystrophic controls. The observed prolongation of the functional ability of injected dystrophic animals suggests that growth hormone plays a role in potentiating the symptoms of dystrophy in chickens.
Kurtenbach
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Departamento de Bioquimica, Universidade Federal do Rio de Janeiro, Brazil.
Moraes
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SS
Trocado
M T
MT
Lôbo
G F
GF
Nascimento
P S
PS
Verjovski-Almeida
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S
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D002645:Chickens; D003402:Creatine Kinase / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D013006:Growth Hormone / Q000276:immunology* / Q000502:physiology; D007106:Immune Sera / Q000032:analysis; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D008297:Male; D009137:Muscular Dystrophy, Animal / Q000628:therapy*
D000888:Antibodies, Anti-Idiotypic; D007106:Immune Sera; D007074:Immunoglobulin G; D013006:Growth Hormone; D003402:Creatine Kinase