[Experimental study on transferability to cerebrospinal fluid of cefodizime in combination with ampicillin].
A study was done on cefodizime (THR-221, CDZM) in combination with ampicillin (ABPC) for its transferability to cerebrospinal fluid (CSF) of rabbits with experimental meningitis caused by Staphylococcus aureus. Blood and CSF were collected at 15, 30, 45, 60, 90, 120 and 180 minutes after intravenous administration of CDZM at 100 mg/kg to 6 rabbits, ABPC at 100 mg/kg to 4 rabbits and simultaneous administration of both drugs at 100 mg/kg each to 5 rabbits. Drug concentrations were assayed with an high performance liquid chromatography method, and pharmacokinetic parameters were calculated. The comparison revealed no significant difference in concentrations achieved among different groups. Therefore, the mutual transferability of these drugs to CSF was not considered to interact adversely due to the simultaneous administration of both drugs. Accordingly, CDZM may be a candidate of chemotherapeutics in the therapy of purulent meningitis, and it is worthy of further investigations.
Okura
K
K
Department of Pediatrics, Kobe City General Hospital.
Haruta
T
T
Kobayashi
Y
Y
D000667:Ampicillin / Q000008:administration & dosage / Q000134:cerebrospinal fluid*; D000818:Animals; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid; D004347:Drug Interactions; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000134:cerebrospinal fluid; D007275:Injections, Intravenous; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000209:etiology; D011817:Rabbits; D013203:Staphylococcal Infections / Q000134:cerebrospinal fluid
D000667:Ampicillin; D002439:Cefotaxime; C033356:cefodizime