title: Quantitative iodine-123 IMP imaging of brain perfusion in schizophrenia.
abstract: Decreased perfusion in the frontal lobes of patients with chronic schizophrenia has been reported by multiple observes using a variety of techniques. Other observers have been unable to confirm this finding using similar techniques. In this study quantitative single photon emission computed tomography brain imaging was performed using p,5n [123I]IMP in five normal subjects and ten chronically medicated patients with schizophrenia. The acquisition data were preprocessed with an image dependent Metz filter and reconstructed using a ramp filtered back projection technique. The uptake in each of 50 regions of interest in each subject was normalized to the uptake in the cerebellum. There were no significant confirmed differences in the comparable ratios of normal subjects and patients with schizophrenia even at the p = 0.15 level. "Hypofrontality" was not observed.
authors: Nuclear Medicine Service, V.A. Medical Center, Sepulveda, California.
authors: M B
authors: MB
authors: Cohen
authors: R R
authors: RR
authors: Lake
authors: L S
authors: LS
authors: Graham
authors: M A
authors: MA
authors: King
authors: A S
authors: AS
authors: Kling
authors: L J
authors: LJ
authors: Fitten
authors: J
authors: J
authors: O'Rear
authors: G A
authors: GA
authors: Bronca
authors: M
authors: M
authors: Gan
authors: R
authors: R
authors: Servrin
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D005625:Frontal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D012559:Schizophrenia / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007457:Iodine Radioisotopes