Spontaneous tumors in F-344/Jcl rats.
The age-related incidence of spontaneously occurring neoplastic and non-neoplastic lesions in untreated F-344/Jcl rats, used as controls in carcinogenicity testing, were studied from the histological examination of tissues from 469 males and 354 females. The incidence of spontaneous tumors was 83.2% in the males and 71.2% in the females. The most common neoplasms were leukemia (males: 24.3%, females: 24.0%), pituitary adenoma (males: 16.0%, females: 45.2%), pheochromocytoma (males: 14.7%, females: 7.3%), testicular interstitial cell tumor (males: 79.1%), and uterine endometrial stromal polyp(females: 16.4%). The incidence of other tumors of almost all the organs and/or tissues was low. Non-neoplastic lesions generally increased with advancing age of the animals.
Takaki
Y
Y
Department of Pathology (I), Juntendo University School of Medicine, Tokyo, Japan.
Kitamura
S
S
Uekusa
T
T
Honma
S
S
Aze
Y
Y
Wakabayashi
K
K
Kuwabara
N
N
Fukuda
Y
Y
D000367:Age Factors; D000818:Animals; D001859:Bone Neoplasms / Q000662:veterinary; D004067:Digestive System Neoplasms / Q000662:veterinary; D004700:Endocrine System Diseases / Q000662:veterinary; D005260:Female; D005833:Genital Neoplasms, Female / Q000662:veterinary; D005834:Genital Neoplasms, Male / Q000662:veterinary; D007938:Leukemia / Q000662:veterinary; D008297:Male; D009135:Muscular Diseases / Q000662:veterinary; D009369:Neoplasms / Q000453:epidemiology / Q000662:veterinary*; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D012142:Respiratory Tract Neoplasms / Q000662:veterinary; D012376:Rodent Diseases / Q000453:epidemiology; D012737:Sex Factors; D012878:Skin Neoplasms / Q000662:veterinary