title: Allergy to nickel or cobalt: tolerance to nickel and cobalt samples in man and in the guinea pig allergic or sensitized to these metals.
abstract: The aim of this study was to evaluate, in animals and humans sensitive to nickel or cobalt, the tolerance to manufactured metal samples of nickel and cobalt of a defined metallographic structure, plated or not with a layer of chrome or copper/chrome of a determined thickness. Under the defined experimental conditions, a guinea pig sensitized to one metal (nickel or cobalt) was intolerant to both metals (nickel and cobalt). A plating of chrome or copper/chrome did not act as a protection. In the human, it was not the same: the tolerance to metal samples was determined by the specific sensitivity. A plating of chrome or copper/chrome did not act as protection.
authors: Institut National de Recherche et de Sécurité, Vandoeuvre, France.
authors: C
authors: C
authors: Cavelier
authors: J
authors: J
authors: Foussereau
authors: P
authors: P
authors: Gille
authors: D
authors: D
authors: Zissu
mesh_terms: D000818:Animals; D002857:Chromium / Q000009:adverse effects; D003035:Cobalt / Q000009:adverse effects* / Q000276:immunology; D003300:Copper / Q000009:adverse effects; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007114:Immunization; D009532:Nickel / Q000009:adverse effects* / Q000276:immunology; D010328:Patch Tests
chemical_list: D002857:Chromium; D003035:Cobalt; C029938:nickel sulfate; D003300:Copper; D009532:Nickel; C018021:cobaltous chloride