Prolonged lung retention of 123I-IMP in pulmonary disease.
The accumulation of venously injected 123I-IMP in the lung was studied. Between 30 and 50 min after the injection of the 1.5 mCi 123I-IMP, the concentration of 123I-IMP in the broncho-alveolar lavage fluid were much higher than in the blood. It was considered that 123I-IMP was transported into the alveolar spaces and was absorbed by the alveolar cells. The half time (T1/2) of the 123I-IMP release from the lung between 10 and 25 min immediately after the injection was calculated. In normal subjects the T1/2 ranged between 25 and 44 min and was prolonged in subjects with pulmonary fibrosis, sarcoidosis, and allergic alveolitis. It was considered that the retention of 123I-IMP was related not only to the endothelial cells, but also to the alveolar cells. It was considered that the analysis of the lung release of 123I-IMP forms a new lung dysfunction index.
Ikeda
H
H
1st Department of Internal Medicine, Yamagata University School of Medicine.
Mariko
M
M
Komatsu
M
M
Takahashi
K
K
Yasui
S
S
Takahashi
K
K
D000662:Amphetamines / Q000493:pharmacokinetics*; D001992:Bronchoalveolar Lavage Fluid / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism*; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000378:metabolism*; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging / Q000378:metabolism; D011877:Radionuclide Imaging; D012507:Sarcoidosis / Q000000981:diagnostic imaging / Q000378:metabolism
D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine