Hemoglobin Nouakchott [alpha 114(GH2)Pro----Leu]: a new hemoglobin variant displaying an unusual increase in hydrophobicity.
The most striking fact in Hb Nouakchott [alpha 114(GH2)Pro----Leu] is the highly increased hydrophobicity of the abnormal chain. In comparison to other variants carrying the same amino-acid substitution, but at another position, the involvement of the environmental domains in the expression of the hydrophobicity is shown. Even though the substitution concerned a proline residue, it was without consequences on the oxygen binding and the stability of the molecule.
Wajcman
H
H
INSERM U299, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
Delaunay
J
J
Francina
A
A
Rosa
J
J
Galacteros
F
F
D000328:Adult; D000595:Amino Acid Sequence; D001665:Binding Sites; D004586:Electrophoresis / Q000379:methods; D005260:Female; D006455:Hemoglobins, Abnormal / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007525:Isoelectric Focusing; D007930:Leucine / Q000032:analysis; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010100:Oxygen / Q000032:analysis; D010455:Peptides / Q000032:analysis; D011392:Proline / Q000032:analysis
D006455:Hemoglobins, Abnormal; D010455:Peptides; C061206:hemoglobin Nouakchott; D011392:Proline; D007930:Leucine; D010100:Oxygen