Benign transient hyperphosphatasia and HIV infection.
The disorder, benign transient hyperphosphatasia, has been defined previously as a condition occurring in a normal child with spontaneous, transient elevation of alkaline phosphatase. We report three cases of hyperphosphatasia in patients with congenital HIV infection and underlying liver disease which appear to satisfy the criteria for benign transient hyperphosphatasia despite the presence of chronic disease. These three children, when compared with three normal children with transient hyperphosphatasia exhibited similar patterns of change in serum alkaline phosphatase. Extreme elevation of serum alkaline phosphatase in HIV infected patients does not of itself suggest alterations in clinical status nor indicate the need for extensive evaluation.
Fennoy
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I
Department of Pediatrics, Columbia University, Harlem Hospital Medical Center, New York, New York 10037.
Laraque
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D
D000367:Age Factors; D000469:Alkaline Phosphatase / Q000097:blood*; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002675:Child, Preschool; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D006679:HIV Seropositivity / Q000201:enzymology*; D006801:Humans; D007223:Infant; D008297:Male; D013420:Sulfamethoxazole / Q000627:therapeutic use; D013997:Time Factors; D014295:Trimethoprim / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000890:Anti-Infective Agents; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D000469:Alkaline Phosphatase; D013420:Sulfamethoxazole