Effects of synthetic salmon calcitonin therapy in children with osteogenesis imperfecta.
A total of four children with osteogenesis imperfecta, three with type I and one with type III forms of the disease, were treated with synthetic salmon calcitonin for 18-24 months. The annual fracture rate was decreased during calcitonin therapy compared with the period preceding it. No patient presented a marked inflexion in linear growth and a transient improvement was even noticed in two cases.
Rebelo
I
I
Department of Pediatrics, Dona Estefânia Hospital, Lisbon, Portugal.
da Silva
L P
LP
Blanco
J C
JC
Monteiro
M E
ME
Ferreira
N C
NC
D000365:Age Determination by Skeleton; D001827:Body Height / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects; D002116:Calcitonin / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D008297:Male; D010013:Osteogenesis Imperfecta / Q000150:complications / Q000188:drug therapy*
D002116:Calcitonin