title: Blood pressure, intraocular pressure, and retinal vessels after high altitude mountain exposure.
abstract: Identical test protocols were used before and after 2 to 7 weeks of high altitude exposure in 23 climbers participating in 3 separate mountain expeditions in the Himalayas. The three groups reached altitudes of 4,000 m, 5,200, and 5,850 m, respectively. High altitude retinal hemorrhages (HARH) were found in three subjects (13%). Two weeks after the mountain exposure, reduced mean values of systolic (p less than 0.005) and diastolic (p less than 0.05) blood pressure and intraocular pressure (p less than 0.005) were found. Retinal veins were dilated 2.6% (p less than 0.001), and in both arteries (p less than 0.001) and veins (p less than 0.005) we observed a tendency for small vessels to dilate and large vessels to constrict. The intensity of reflection of light ("the central light reflex") from arteries was reduced (p = 0.003), indicating hemorrheology changes in the vessels. This study shows that significant changes in blood pressure, intraocular pressure and retinal vascularity follow hypoxic and physical strain of high altitude. The vascular conditioning of altitude acclimatization can be demonstrated in the retinal circulation 2 weeks after the exposure.
authors: Eye Department, Ullevål University Hospital, Oslo, Norway.
authors: O
authors: O
authors: Brinchmann-Hansen
authors: K
authors: K
authors: Myhre
mesh_terms: D000328:Adult; D000368:Aged; D000531:Altitude; D000532:Altitude Sickness / Q000453:epidemiology; D005260:Female; D006801:Humans; D007022:Hypotension / Q000453:epidemiology*; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009051:Mountaineering; D005082:Physical Exertion; D010809:Physical Fitness; D012166:Retinal Hemorrhage / Q000453:epidemiology; D012171:Retinal Vessels / Q000502:physiology*; D014664:Vasodilation