Lomefloxacin, a new difluoroquinolone: in vitro activity against gram-positive and gram-negative bacteria.
The in vitro activity of lomefloxacin, a new difluoro-quinolone, was compared to other antimicrobial agents against a selection of Gram-positive and Gram-negative organisms. Against the Enterobacteriaceae, the lomefloxacin MIC inhibiting 90% of strains was less than or equal to 0.5 micrograms/ml. Ninety per cent of Pseudomonas aeruginosa and Acinetobacter sp. isolates were inhibited at less than or equal to 4 micrograms/ml. All staphylococci including methicillin-resistant organisms were susceptible at 1.0 micrograms/ml. Enterococcus faecalis, Listeria spp., and sero Group B streptococci were more resistant with an MIC90 of 8, 16 and 4 micrograms/ml, respectively.
Hoban
D
D
Department of Clinical Microbiology, Health Sciences Centre, Winnipeg, Manitoba, Canada.
Grabowski
M
M
Koss
J
J
Weselowski
V
V
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D015363:Quinolones
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin