Interleukin-1 induced vascular pathology "in vivo": a scanning electron-microscopy study.
Ethylene vinyl acetate (EVA) discs containing either 50 U interleukin-1 (IL-1) or 250 mg bovine serum albumin as control were implanted around the exposed jugular veins of rabbits. After 24 hr, the veins were examined by scanning electron-microscopy. Compared with minor changes in control vein lumena, those of EVA-IL-1 treated veins showed extensive endothelial cell denudation and exposure of basement membrane associated with platelet accumulation and adherence/subendothelial migration of leucocytes. These observations suggest that locally-released IL-1 provokes significant vascular pathological changes "in vivo" and emphasise the importance of this cytokine as a mediator of inflammatory and thrombotic/atherosclerotic diseases.
Dunn
C J
CJ
Department of Hypersensitivity Diseases Research, Upjohn Company, MI Kalamazoo, MI 49001.
Schaub
R G
RG
Fleming
W E
WE
Gibbons
A J
AJ
D000818:Animals; D007375:Interleukin-1 / Q000633:toxicity*; D008297:Male; D008855:Microscopy, Electron, Scanning; D011145:Polyvinyls; D011817:Rabbits; D012710:Serum Albumin, Bovine; D014652:Vascular Diseases / Q000139:chemically induced* / Q000473:pathology
D007375:Interleukin-1; D011145:Polyvinyls; C016438:ethylenevinylacetate copolymer; D012710:Serum Albumin, Bovine