[Effect of adaptation to continuous and intermittent hypoxia on heart resistance to ischemic and reperfusion arrhythmias].
The effect of adaptation to intermittent hypoxia in a pressure chamber (5.000 m daily for 6 hours for 30 days) on arrhythmias occurring in occlusion of the coronary artery and subsequent reperfusion in rats was compared with the effect of adaptation to continuous hypoxia at middle-mountain altitudes. Adaptation to intermittent hypoxia reduced the duration of severe ventricular arrhythmias in acute ischemia and reperfusion to a great measure. Adaptation to continuous hypoxia at middle-mountain altitudes has a similar effect only in ischemic arrhythmias but at the same time promotes the development of reperfusion arrhythmias. The possible mechanisms of these effects are discussed.
Meerson
F Z
FZ
Beloshitskiĭ
P V
PV
Vorontsova
E Ia
EIa
Ustinova
E E
EE
Rozhitskaia
I I
II
D000222:Adaptation, Physiological; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology*; D003326:Coronary Circulation; D003327:Coronary Disease / Q000150:complications*; D008297:Male; D010100:Oxygen / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010100:Oxygen
Vliianie adaptatsii k deĭstviiu nepreryvnoĭ i periodicheskoĭ gipoksii na rezistentnost' serdtsa k ishemicheskim i reperfuzionnym aritmiiam.