Effects of indomethacin on erythropoiesis and plasma iron in rats.
The effect of indomethacin on erythropoiesis and plasma iron in rats is investigated after 3-day treatment. A more considerable decrease of erythrocytes, haemoglobin and plasma iron is observed, as well as an increase in reticulocytes and 59Fe incorporated in the newly-formed erythrocytes. The plasma bilirubin and lactate levels are also higher. Obviously, this suggests a regeneratory anaemia. It is concluded that prostaglandins are necessary for the normal iron metabolism and for erythropoiesis, but their absence does not prevent entirely the process of erythroid regeneration.
Ganchev
T
T
Physiology Department, Higher Medical Institute, Varna.
Negrev
N
N
Mileva
V
V
D000818:Animals; D001663:Bilirubin / Q000097:blood; D004920:Erythropoiesis / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology*; D007501:Iron / Q000097:blood*; D007504:Iron Radioisotopes; D007773:Lactates / Q000097:blood; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D007504:Iron Radioisotopes; D007773:Lactates; D011453:Prostaglandins; D007501:Iron; D001663:Bilirubin; D007213:Indomethacin