title: Capillary gas chromatographic determination of epomediol in human plasma and urine using a rapid solid-phase extraction.
abstract: A simple and precise method for the quantitation of epomediol in human plasma and urine is described. Each biological sample is added with the internal standard and applied directly to an Extrelut-1 solid-phase column. After absorption the column is eluted with chloroform and the eluate is evaporated to dryness. The residue, reconstituted in ethanol, is analysed by capillary gas chromatography. No interferences from possible metabolites or endogenous constituents can be noted. The method has been applied to human pharmacokinetic studies: the results of a subacute administration to volunteers are presented.
authors: Dipartimento di Chimica Analitica, Camillo Corvi, S.p.A., Piacenza, Italy.
authors: M A
authors: MA
authors: Girometta
authors: L
authors: L
authors: Loschi
authors: P
authors: P
authors: Ventura
authors: S
authors: S
authors: Canali
authors: C
authors: C
authors: Giachetti
authors: G
authors: G
authors: Zanolo
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic; D002756:Cholagogues and Choleretics / Q000032:analysis* / Q000097:blood / Q000652:urine; D002849:Chromatography, Gas / Q000379:methods*; D006801:Humans; D013729:Terpenes / Q000097:blood / Q000652:urine
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D002756:Cholagogues and Choleretics; D013729:Terpenes; C031365:epomediol