title: Modelling the occurrence and pathology of Alzheimer's disease.
abstract: Our work has confirmed that of St. George-Hyslop and colleagues, suggesting FAD linkage to the short arm of chromosome 21 in outbred families with a presenile onset of the disease. Future genetic studies should help clarify the current apparent discrepancies between certain laboratories and ultimately lead to a better understanding of the variables which predispose individuals to the disease.
authors: Department of Biochemistry, St. Mary's Hospital Medical School, London.
authors: J A
authors: JA
authors: Hardy
authors: A M
authors: AM
authors: Goate
authors: M J
authors: MJ
authors: Owen
authors: M J
authors: MJ
authors: Mullan
authors: M N
authors: MN
authors: Rossor
authors: R C
authors: RC
authors: Pearson
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D002891:Chromosomes, Human, Pair 21; D008040:Genetic Linkage; D006801:Humans; D008875:Middle Aged