Lactation inhibits stress-mediated secretion of corticosterone and oxytocin and hypothalamic accumulation of corticotropin-releasing factor and enkephalin messenger ribonucleic acids.
The effect of lactation on stress-induced hormone responses and changes in hypothalamic mRNA was assessed in female rats. In control animals the stimulus of ip hypertonic saline resulted in increased plasma levels of corticosterone, oxytocin, and vasopressin and hypothalamic content of CRF and enkephalin mRNA. In lactating females, however, the corticosterone response to this stress failed to reach significance, the plasma oxytocin response was markedly reduced, and the vasopressin response was unaffected. Lactation also resulted in an abolition of the CRF and enkephalin mRNA responses to stress. In contrast, the hypothalamic CRF response to adrenalectomy was unaffected by lactation status. Removal of the pups from their mothers resulted in a return of CRF and enkephalin mRNA responses to stress within 2 days. Lactation is associated with a selective inhibition of normal hypothalamic stress responses.
Lightman
S L
SL
Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892.
Young
W S
WS
D000818:Animals; D003345:Corticosterone / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000235:genetics*; D004745:Enkephalins / Q000235:genetics*; D005260:Female; D006728:Hormones / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007774:Lactation / Q000502:physiology*; D010121:Oxytocin / Q000378:metabolism; D011247:Pregnancy; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D013312:Stress, Physiological / Q000378:metabolism*
D004745:Enkephalins; D006728:Hormones; D012333:RNA, Messenger; D012462:Saline Solution, Hypertonic; D010121:Oxytocin; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone