Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes.
The serum of children with untreated hemophagocytic syndromes contains elevated levels (23,600 to 75,200 U/mL) of soluble interleukin-2 receptor (SIL2R) that returns toward normal with clinical improvement. These levels are in excess of levels previously reported for benign conditions. They are as high as levels reported for HTLV-1-associated adult T-cell leukemia (HATL) and hairy cell leukemia (HCL) in adults and some children with poor-prognosis non-T, non-B, acute lymphoblastic leukemia (ALL). Serum SIL-2R is a marker of disease activity that has the potential to identify infants at risk for the inherited form of the disease before the disease is clinically expressed.
Komp
D M
DM
Department of Pediatrics, Howard Hughes Medical Institute, New Haven, CT 06510.
McNamara
J
J
Buckley
P
P
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007244:Infectious Mononucleosis / Q000097:blood; D008206:Lymphatic Diseases / Q000097:blood* / Q000276:immunology; D008264:Macrophages / Q000032:analysis / Q000473:pathology; D010587:Phagocytosis; D010920:Placenta / Q000032:analysis / Q000473:pathology; D015375:Receptors, Interleukin-2 / Q000097:blood*; D013577:Syndrome
D015375:Receptors, Interleukin-2