An additional breakpoint region in the BCL-1 locus associated with the t(11;14)(q13;q32) translocation of B-lymphocytic malignancy.
The t(11;14)(q13;q32) translocation is associated with human B-lymphocytic malignancy. This translocation divides the IgH locus on chromosome 14q32 and may activate a postulated proto-oncogene, bcl-1, located on chromosome 11q13. Two samples of chronic lymphocytic leukemia with the t(11;14)(q32;q13) translocation were studied. The break in one sample was shown to join Jh sequences with the previously described bcl-1 major translocation cluster. DNA blots of the second sample suggested that Jh sequences were joined to a different breakpoint region on chromosome 11. This translocation was cloned and found to link the human Jh3 region and a new breakpoint region 63 kb telomeric of the major translocation cluster. This translocation occurred in part as the result of an aberrant D-J recombination. Recurrent translocations human B-lymphocytic malignancy. The definition of a new breakpoint region may aid the identification of the postulated bcl-1 gene.
Meeker
T C
TC
Department of Medicine, University of California, San Francisco.
Grimaldi
J C
JC
O'Rourke
R
R
Louie
E
E
Juliusson
G
G
Einhorn
S
S
D001483:Base Sequence; D002460:Cell Line; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D004273:DNA, Neoplasm / Q000235:genetics; D005803:Genes, Immunoglobulin; D015698:Genomic Library; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data; D000090063:Proto-Oncogene Mas; D011947:Receptors, Antigen, B-Cell / Q000235:genetics*; D015183:Restriction Mapping; D014178:Translocation, Genetic
D004273:DNA, Neoplasm; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011947:Receptors, Antigen, B-Cell