Immunomodulating properties of the N-(1-deoxy-D-fructos-lyl) derivative of amphotericin B in mice.
Immunomodulating properties of the N-(1-deoxy-D-fructos-lyl) derivative of Amphotericin B (N-Fru-AmB) was investigated in vitro on T and B mouse lymphocytes and compared to that of the original AmB molecule. Results indicate that N-Fru-AmB is a potent polyclonal B cell activator capable of inducing B lymphocytes to proliferate and to differentiate into Ig secreting cells in absence of any additional signal. N-Fru-AmB is also mitogenic for a fraction of peripheral T lymphocytes. Together, the results suggest a potential interest of such derivatives in the treatment of mycosal infections in immunodeficient patients.
Henry-Toulmé
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N
Laboratoire de Physique et Chimie Biomoléculaire, CNRS UA198, Université Paris.
Hermier
B
B
Seman
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M
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005260:Female; D007075:Immunoglobulin M / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D013268:Stimulation, Chemical; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D007075:Immunoglobulin M; C059463:N-(1-deoxyfructosyl)amphotericin B; D000666:Amphotericin B