title: [Treatment of chronic glomerulonephritis with cytostatics].
abstract: A retrospective analysis was made of the efficacy of oral treatment with cytostatics (azathioprin, batriden, cyclophosphamide) in 109 patients with chronic glomerulonephritis (CGN) (with a known morphologic appearance in 94 patients) and with excessive doses of cyclophosphamide i. v. in 32 patients with CGN depending on the nephritis standing, its clinical pattern and morphologic variant. The best results were recorded with nephritis lasting up to 2 years in patients suffering from the nephrotic pattern of CGN or at the stage of the nephrotic syndrome formation in patients with latent CGN, in membranoproliferative, membranous and membranocapillary versions of CGN, during pulse therapy, and in patients with focal segmental glomerulohyalinosis. No remissions were observed in mixed CGN. The experimental data are also provided concerning the influence of a single oral cyclophosphamide administration on the morphologic signs of nephritis in GBA and C57BL mice.
authors: I E
authors: IE
authors: Tareeva
authors: N B
authors: NB
authors: Gordovskaia
authors: O P
authors: OP
authors: Gladskikh
authors: A A
authors: AA
authors: Ivanov
authors: T N
authors: TN
authors: Krasnova
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001379:Azathioprine / Q000627:therapeutic use; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000188:drug therapy*; D006072:Gossypol / Q000031:analogs & derivatives*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; C016259:batridene; D003520:Cyclophosphamide; D006072:Gossypol; D001379:Azathioprine
vernacular_title: Lechenie khronicheskogo glomerulonefrita tsitostatikami.