title: [Change in the number of epidermal growth factor receptors of hepatocytes during liver regeneration in rats].
abstract: The number of epidermal growth factor (EGF) receptors was determined for rat's hepatocytes under condition of their regeneratory proliferation, following a partial hepatectomy. In the normal hepatocytes two classes of EGF-receptors are distinguished, with high and low affinity, respectively. As early as 2 hours after the partial hepatectomy the total number of EGF-receptors sharply decreases, those with high affinity being not determined at all. The patterns of autophosphorylation of EGF-receptors with low affinity, examined in regenerating liver hepatocytes, remained the same as in the intact liver: their kinase activity was EGF-dependent, tyrosine residues of receptor molecules, with molecular mass equal to 150-170 kDa, underwent phosphorylation.
authors: Iu D
authors: IuD
authors: Ivashchenko
authors: I T
authors: IT
authors: Gut
authors: L V
authors: LV
authors: Garmanchuk
authors: G A
authors: GA
authors: Kulik
authors: A I
authors: AI
authors: Vykorez
mesh_terms: D000818:Animals; D004815:Epidermal Growth Factor / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism*; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D010766:Phosphorylation; D051381:Rats
chemical_list: D004815:Epidermal Growth Factor; D066246:ErbB Receptors
vernacular_title: Izmenenie kolichestva retseptorov épidermal'nogo faktora rosta gepatotsitov pri regeneratsii pecheni u krys.