[Sequential study of glioblastoma with high uptake of N-isopropyl-p-[123I]iodoamphetamine: a case report].
A case of glioblastoma with high uptake of N-isopropyl-p-[123I]iodoamphetamine (IMP) is presented. The lesion on a X-ray CT showed an enhanced area with a cyst, in which angiography, operative findings and histological investigations revealed abundant vessels. A pretreatment Xe-SPECT study showed that the tumor blood flow was higher than a healthy cortex blood flow. Also, high IMP uptake was observed using an IMP-SPECT early image, 20 minutes after IMP intravenous injection. Furthermore it was noted in the delayed image 2 hours later. After intraoperative and external radiation therapy, both the tumor blood flow, as determined by Xe-SPECT, and the IMP uptake were seen to gradually decrease, while the thallium-201 uptake was high. These findings suggested that the IMP uptake in tumor tissue accurately reflects the tumor blood flow if there is no arteriovenous fistula in the tumor. On conclusion, IMP-SPECT early images might reflect both the tumor blood flow and the vascular architecture.
Araki
Y
Y
Yamada
H
H
D000662:Amphetamines / Q000493:pharmacokinetics; D001932:Brain Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000378:metabolism; D005910:Glioma / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D014055:Tomography, Emission-Computed
D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine