Borna disease, a progressive meningoencephalomyelitis as a model for CD4+ T cell-mediated immunopathology in the brain.
A homogeneous T cell line NM1 with Borna disease (BD) virus reactivity could be established. The NM1 cells have been characterized as CD4+ T cells. Adoptive transfer revealed that this MHC class II-restricted immune cell is responsible for the immunopathological effect leading to BD, a progressive meningoencephalomyelitis.
Richt
J A
JA
Institut für Virologie, Justus-Liebig-Universität Giessen, Federal Republic of Germany.
Stitz
L
L
Wekerle
H
H
Rott
R
R
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D001890:Borna Disease / Q000276:immunology*; D001891:Borna disease virus / Q000276:immunology; D004195:Disease Models, Animal; D008590:Meningoencephalitis / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte