The use of streptomycin to induce unilateral ablation of vestibular function in the rat: a preliminary report.
The goal of our research is to develop a method of applying streptomycin to the middle ear so as to destroy vestibular function unilaterally while avoiding damage to auditory function. In this preliminary experiment, a total of 42 mg of streptomycin was infused continuously over a seven-day period into one middle ear cavity of seven rats, with the opposite ear serving as a control. Histologic study revealed a moderate to severe degree of vestibular neuroepithelial damage in all of the infused ears. However, significant damage also occurred in the basal turn of the cochlea in a majority of cases.
Proctor
L R
LR
Department of Otolaryngology--Head & Neck Surgery, Johns Hopkins University, Baltimore, MD.
el-Kashef
Y
Y
D000042:Absorption; D000818:Animals; D003051:Cochlea / Q000187:drug effects; D007758:Ear, Inner / Q000187:drug effects / Q000378:metabolism; D004432:Ear, Middle / Q000378:metabolism; D004848:Epithelium / Q000187:drug effects; D007260:Infusion Pumps; D007263:Infusions, Parenteral; D008297:Male; D051381:Rats; D013307:Streptomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D013307:Streptomycin