Effects of neuropeptide Y and calcitonin gene-related peptide on local cerebral blood flow in rat striatum.
The effects of neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) on local cerebral blood flow (LCBF) were studied in vivo in rat striatum. Administration of 1 and 5 nmol NPY as a bolus into the internal carotid artery caused a dose-dependent decrease in the ipsilateral striatal LCBF. This decrease developed slowly and persisted for at least 2 h, without affecting mean blood pressure. In contrast, CGRP, at a concentration of 10 pmol, increased striatal LCBF by about 30%, and the duration of the increase was about 1 h. However, at higher doses of CGRP no increase in LCBF was observed. These results suggest that NPY and CGRP released from nerve fibers innervating blood vessels can function as long-acting modulators of CBF.
Suzuki
Y
Y
Department of Neurosurgery, Nagoya University School of Medicine, Japan.
Satoh
S
S
Ikegaki
I
I
Okada
T
T
Shibuya
M
M
Sugita
K
K
Asano
T
T
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide; D003342:Corpus Striatum / Q000098:blood supply* / Q000187:drug effects; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology*; D009479:Neuropeptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009478:Neuropeptide Y; D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide