Effects of indeloxazine hydrochloride on passive avoidance behavior of senescence-accelerated mice.
The effects of indeloxazine hydrochloride on disturbances of passive avoidance behavior in senescence-accelerated mice (SAM) were observed. The step-through latency of SAM-P/8/Ta (SAM-P/8, senescence-prone substrain) was significantly shorter than that of SAM-R/1/Ta (SAM-R/1, senescence-resistant substrain). The administration of indeloxazine (10-30 mg/kg p.o.) or dihydroergotoxine (1 mg/kg i.p.) for 3 weeks significantly prolonged the step-through latency of SAM-P/8/Ta whereas piracetam (30-300 mg/kg p.o.) did not. These results suggest that indeloxazine has a facilitatory effect on cerebral functions and that it has a broader pharmacological profile in anti-amnesic activities than piracetam.
Yamamoto
M
M
Department of Pharmacology, Central Research Laboratories, Yamanouchi Pharmaceutical Co. Ltd., Tokyo, Japan.
Iwai
A
A
Kawabata
S
S
Ozawa
Y
Y
Shimizu
M
M
D000375:Aging / Q000502:physiology*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects; D003513:Cycloheximide / Q000494:pharmacology; D004088:Dihydroergotoxine / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D008815:Mice, Inbred Strains; D009025:Morpholines / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology; D012601:Scopolamine / Q000494:pharmacology
D000928:Antidepressive Agents; D009025:Morpholines; D004088:Dihydroergotoxine; C020852:indeloxazine; D003513:Cycloheximide; D012601:Scopolamine; D010889:Piracetam