The effect of using T-activin in the therapy of the newborn with suppurative surgical infection.
A total of 156 newborn infants with suppurative surgical infection (SSI) were observed; 73 of them had sepsis and 83 a severe localized process. In 47 patients with sepsis and 34 with localized infection, T-activin was included in complex therapy while the other infants formed the control group. It has been established that T-activin leads to an increase in the quantity of the active population of T-lymphocytes in the peripheral blood and to enhanced functional activity of T-lymphocytes in the newborn with SSI independent of generalization of the process. Bactericidal activity of circulating phagocytes is improved. The clinical course of SSI is less severe with more pronounced positive changes in the symptoms, hospital stay of the children is shortened, lethality is reduced. The effect of T-activin on the dynamic of the indices of the immune state is more marked in a septic process.
Samsygin
S A
SA
A. N. Bakulev Institute of Cardiovascular Surgery, Academy of Medical Sciences of the USSR, Moscow.
Dolgina
E N
EN
Arion VYa
Romanova
L A
LA
Shchevochkina
G I
GI
Ovchinnikova
E A
EA
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D007231:Infant, Newborn; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology; D010455:Peptides / Q000627:therapeutic use*; D012397:Rosette Formation; D013492:Suppuration; D013530:Surgical Wound Infection / Q000276:immunology / Q000628:therapy*; D013949:Thymus Extracts / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin