title: [Drugs from the classes of tricyclic antidepressives and antiepileptics, nitrosatable under simulated human gastric conditions].
abstract: The nitrosatability of Pryleugan (imipramine), Herphonal (trimipramine), and Finlepsin (carbamazepine) was investigated under simulated human gastric conditions using a colorimetric measuring method. All of them proved to be nitrosatable even at very low nitrite concentrations. In the presence of ascorbic acid, the formation of N-nitroso compounds under model conditions was inhibited markedly. N-nitroso-dihydrodibenzazepine and N-nitroso-dibenzazepine could be identified by thin layer chromatography as main products. The biological effects of these N-nitroso compounds are not known up to now.
authors: Zentralinstitut für Krebsforschung, Akademie der Wissenschaften der DDR, Robert-Rössle-Institut, Berlin-Buch.
authors: D
authors: D
authors: Ziebarth
authors: T
authors: T
authors: Schramm
authors: A
authors: A
authors: Töppel
mesh_terms: D002220:Carbamazepine / Q000378:metabolism*; D003984:Dibenzazepines / Q000032:analysis / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D007099:Imipramine / Q000378:metabolism*; D066298:In Vitro Techniques; D009573:Nitrites / Q000008:administration & dosage / Q000378:metabolism; D009602:Nitrosamines / Q000032:analysis; D015538:Nitrosation; D009603:Nitroso Compounds / Q000378:metabolism*; D014299:Trimipramine / Q000378:metabolism*
chemical_list: D003984:Dibenzazepines; D009573:Nitrites; D009602:Nitrosamines; D009603:Nitroso Compounds; D002220:Carbamazepine; C061273:N-nitrosodibenzazepine; D014299:Trimipramine; C061274:N-nitrosodihydrodibenzazepine; D007099:Imipramine
vernacular_title: Unter simulierten Bedingungen des menschlichen Magens nitrosierbare Arzneimittel aus den Gruppen der trizyklischen Antidepressiva und Antiepileptika.