Increase in gastric secretion induced by 2-deoxy-D-glucose is impaired in capsaicin pretreated rats.
Gastric acid secretion was determined following intravenous administration of 2-deoxy-D-glucose (2-DG; 60 mg kg-1) or electrical stimulation of the vagus nerve in urethane-anaesthetized rats pretreated when newborn with either capsaicin or the vehicle. The secretory response to 2-DG was substantially reduced in the capsaicin pretreated rats, while that induced by electrical vagal stimulation (1 mA, 1 ms. 3 Hz) was unaffected. These results suggest that capsaicin-sensitive fibres are involved in the afferent branch of the reflex response activated by 2-DG to stimulate gastric acid secretion.
Evangelista
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S
Pharmacology Department, Menarini Pharmaceuticals, Firenze, Italy.
Santicioli
P
P
Maggi
C A
CA
Meli
A
A
D000818:Animals; D002211:Capsaicin / Q000008:administration & dosage / Q000494:pharmacology*; D003837:Deoxy Sugars / Q000037:antagonists & inhibitors*; D003847:Deoxyglucose / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology
D003837:Deoxy Sugars; D003847:Deoxyglucose; D002211:Capsaicin