title: [Preparation and pharmacologic activity of N-oxides of 4'-(benzotriazol-2-yl-phenylalkanoic and -phenoxyalkanoic acids].
abstract: A number of N-oxides of 4'-(benzotriazol-2-yl)-phenylalkanoic and -phenoxyalkanoic acids bearing various substituents on position 6 of benzotriazole together with 4'-(benzotriazol-2-yl) phenylacetic acid were prepared and subjected to a wide pharmacological screening. Several compounds exhibited significant antiinflammatory and diuretic activities, while one was endowed with antihypertensive activity.
authors: Istituto di Scienze Farmaceutiche, Università di Genova.
authors: A
authors: A
authors: Boido
authors: I
authors: I
authors: Vazzana
authors: F
authors: F
authors: Sparatore
authors: B
authors: B
authors: Cappello
authors: V
authors: V
authors: Diurno
authors: C
authors: C
authors: Matera
authors: R
authors: R
authors: Marrazzo
authors: S
authors: S
authors: Russo
authors: M L
authors: ML
authors: Cenicola
authors: E
authors: E
authors: Marmo
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004232:Diuretics / Q000138:chemical synthesis*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014563:Urodynamics / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D002264:Carboxylic Acids; D004232:Diuretics; D014230:Triazoles
vernacular_title: Preparazione e attività farmacologica di n-ossidi di acidi 4'-(benzotriazol-2-il)-fenilalcanoici e-fenossialcanoici.