[Diffusion of ofloxacin in infected ascitic fluid].
The ofloxacin diffusion was investigated in 13 cirrhotic patients with spontaneous bacterial peritonitis. Plasma and ascitic samples were collected at times H1, H31 and H8 after a first dose of 200 mg per os, in these 13 patients, after 4.5 or 6 days of 200 mg per os each 8 hours in 9 out of them. After the first dose, the plasmatic and ascitic concentrations, measured by High Performance Liquid Chromatography (HPLC), were between 0 and 3.62 mg/l, 0 and 1.95 mg/l respectively. The steady state concentrations are higher than the MIC'S for the organisms most commonly involved, comparable in the plasma and the ascitic fluid is good and suggest the interest of its use in this indication.
Latrive
J P
JP
Service d'Hépatogastroentérologie, Centre Hospitalier de Compiègne, Compiègne.
Barbare
J C
JC
Darchis
J P
JP
Farinotti
R
R
Noel
F
F
D000328:Adult; D000368:Aged; D001201:Ascites / Q000188:drug therapy; D001202:Ascitic Fluid / Q000378:metabolism*; D004058:Diffusion; D005260:Female; D006801:Humans; D007239:Infections / Q000188:drug therapy; D008103:Liver Cirrhosis / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000493:pharmacokinetics* / Q000627:therapeutic use
D015242:Ofloxacin
Diffusion de l'ofloxacine dans l'ascite infectée.