title: Acquired platelet dysfunction with eosinophilia: review of seven adult cases.
abstract: Seven adults with acquired platelet dysfunction with eosinophilia presented with histories of spontaneous bruising and three also had moderate thrombocytopenia. Six patients had platelet function tests performed and all showed variable storage pool defects. When assayed, IgE concentrations were raised. Although only two patients had parasites isolated in their stools, all seven responded to antihelminth treatment. It is speculated that the IgE response to parasites mediates mast cell degranulation, which leads to in vivo platelet activation.
authors: Department of Haematology, Singapore General Hospital.
authors: S H
authors: SH
authors: Lim
authors: C E
authors: CE
authors: Tan
authors: T
authors: T
authors: Agasthian
authors: L S
authors: LS
authors: Chew
mesh_terms: D000328:Adult; D001791:Blood Platelet Disorders / Q000150:complications*; D004802:Eosinophilia / Q000150:complications*; D006801:Humans; D008297:Male; D015539:Platelet Activation; D010979:Platelet Function Tests; D013577:Syndrome