[Characteristics of the combined action of melatonin and imizin on the structure of forced swimming and the circadian rhythm].
Acute administration of melatonin (10 mg/kg) produced a depressed effect on the mice behavior. But it's injection after chronic imipramine (10 mg/kg/day, 2 weeks) potentiated antidepressant ability and shortened the duration of immobility in the structure of swimming. In rats, which had a high amplitude of circadian rest-activity rhythm, melatonin produced imipramine effect on circadian mobility, but potentiated antidepressant action in animals with low initial level of locomotor activity.
Arushanian
E B
EB
Baturin
V A
VA
Ovanesov
K B
KB
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D004347:Drug Interactions; D005260:Female; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D005082:Physical Exertion / Q000187:drug effects*; D013550:Swimming
D008550:Melatonin; D007099:Imipramine
Osobennosti sochetannogo deĭstviia melatonina i imizina na strukturu prinuditel'nogo plavaniia i tsirkadiannogo ritma.