[Characteristics of local immunity in newborn infants].
The secretory immune system was found to be different in neonates and their mothers. The differences manifested in the low content of IgA and high content of the free secretory component in the child's saliva and tears as well as in neonatal milk. In order to study the local immunity of neonates, use was made of neonatal milk as a research object. The system of the complement C3-component synthesis on the mucous membranes appeared mature even in the neonatal period. Based on a comparative analysis of the subpopulations of the immunocompetent cells of blood and milk of neonates and their mothers the conclusion is made about the activation in the neonatal period of the immune system of the mucous membranes associated with the low functional activity of the systemic immunity. The comparative analysis of the immunosuppressive properties of the breast and neonatal milk has demonstrated that the low suppressor activity of secretory factors of the neonates' mucous membranes may be one of the causes of the local immunity activation.
Chernyshov
V P
VP
Slukvin
I I
II
D000328:Adult; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007128:Immunoglobulin Fragments / Q000032:analysis*; D007231:Infant, Newborn / Q000276:immunology*; D008895:Milk, Human / Q000276:immunology; D012463:Saliva / Q000276:immunology*; D012635:Secretory Component / Q000032:analysis*; D013601:T-Lymphocytes / Q000276:immunology; D013666:Tears / Q000276:immunology*
D007070:Immunoglobulin A; D007128:Immunoglobulin Fragments; D012635:Secretory Component
Osobennosti mestnogo immuniteta novorozhdennykh.