[Effects of clopheline on impulse activity of neurons in the midbrain and dorsal horn of the spinal cord].
Clophelin (1-5 mg/kg) suppresses spinal dorsal horn neuronal nociceptive responses but does not change their touch stimuli reactions in unanesthetized curarized cats. This effect is steady to naloxone (1 mg/kg), yohimbine (5 mg/kg) and removal by prazosin (1 mg/kg). Clophelin depresses nociceptive responses of the central gray matter neurones which generalized pain impulses in the supraspinal structures.
Zaĭtsev
A A
AA
Butkhuzi
S M
SM
Kolchin
V V
VV
Moroz
B T
BT
Sakvarelidze
Z A
ZA
D000818:Animals; D002415:Cats; D003000:Clonidine / Q000494:pharmacology*; D008636:Mesencephalon / Q000187:drug effects* / Q000503:physiopathology; D009270:Naloxone / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000503:physiopathology; D011224:Prazosin / Q000494:pharmacology; D013116:Spinal Cord / Q000187:drug effects* / Q000503:physiopathology; D015016:Yohimbine / Q000494:pharmacology
D015016:Yohimbine; D009270:Naloxone; D003000:Clonidine; D011224:Prazosin
Vliianie klofelina na impul'snuiu aktivnost' neĭronov srednego mozga i zadnego roga spinnogo mozga.