title: A malignant peripheral nerve sheath tumor in association with a paratesticular ganglioneuroma.
abstract: A malignant peripheral nerve sheath (PNS) tumor and a benign ganglioneuroma were present as a composite tumor in the paratesticular area of a 15-year-old boy. The pathologic diagnosis was made by characteristic histologic and ultrastructural features and was supported by the demonstration of neuron-specific enolase (NSE)-positive ganglion cells and S-100-protein-positive spindle cells consistent with schwannian cells. The patient has remained disease-free for 3 years since the orchiectomy and the retroperitoneal lymph node dissection, which was followed by combination chemotherapy.
authors: Department of Pathology, Indiana University School of Medicine, Indianapolis.
authors: E
authors: E
authors: Banks
authors: M
authors: M
authors: Yum
authors: C
authors: C
authors: Brodhecker
authors: M
authors: M
authors: Goheen
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005729:Ganglioneuroma / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000473:pathology*; D009378:Neoplasms, Multiple Primary; D009919:Orchiectomy; D010524:Peripheral Nervous System Neoplasms / Q000473:pathology* / Q000628:therapy; D013736:Testicular Neoplasms / Q000473:pathology* / Q000628:therapy; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide