Recovery of auditory function following intense sound exposure in the neonatal chick.
We report the changes in auditory function that occurred at selected intervals following exposure to an intense pure-tone stimulus. One day old chicks were exposed to a 0.9 kHz tone for 48 h at 120 dB. At 0, 1, 3, 6, 9, 12 and 15 days after exposure, cochlear nucleus sound-evoked potentials were used to assess threshold sensitivity and frequency selectivity. Immediately after removal from the pure tone a threshold shift of 60 dB relative to age-matched controls was measured. The sharpness of tuning curves, as measured by Q10 dB, decreased by over 50%. By post-exposure day 15, near complete recovery of function was seen, with the greatest recovery occurring within the first three days. We relate these results to recent reports of structural recovery on the basilar papilla of the chick.
McFadden
E A
EA
Department of Otolaryngology and Human Communication, Medical College of Wisconsin, Milwaukee 53226.
Saunders
J C
JC
D000818:Animals; D000831:Animals, Newborn; D001309:Auditory Threshold / Q000502:physiology; D001489:Basilar Membrane / Q000293:injuries / Q000503:physiopathology; D002645:Chickens; D005072:Evoked Potentials, Auditory / Q000502:physiology; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology*; D013997:Time Factors