Effect of liposomes on hamster oral mucosa.
The histologic reaction to topically applied or intramucosally injected DPPC/chol (2:1 molar ratio) liposomes was investigated. No reaction to liposomes was observed 4 days after daily topical application. However, a mild focal immune type inflammatory reaction was observed after 21 days topical treatment. Intramucosal injection of liposome produced no irritation but a macrophage reaction limited to the injection site, which was followed by healing and complete tissue regeneration.
Foong
W C
WC
College of Pharmacy, Dalhousie University Halifax, N.S., Canada.
Harsanyi
B B
BB
Mezei
M
M
D015060:1,2-Dipalmitoylphosphatidylcholine; D000278:Administration, Buccal; D000287:Administration, Topical; D000818:Animals; D002610:Cheek; D002784:Cholesterol; D006224:Cricetinae; D004337:Drug Carriers; D005260:Female; D008081:Liposomes / Q000009:adverse effects / Q000494:pharmacology*; D009061:Mouth Mucosa / Q000187:drug effects*
D004337:Drug Carriers; D008081:Liposomes; D015060:1,2-Dipalmitoylphosphatidylcholine; D002784:Cholesterol