Thirty-one autopsy cases of trisomy 18: clinical features and pathological findings.
The clinical features and morphological findings in 31 Japanese infants with trisomy 18 are presented. The majority were small-for-date infants. There was no sex predominance in our series, as opposed to male:female ratios of 1:3 reported in the literature. The average age at death was greater in females than in males. Cardiovascular anomalies were consistently present; ventricular septar defect and patent ductus arteriosus being the most common malformations. Various other internal malformations including the Arnold-Chiari malformation were observed.
Kinoshita
M
M
2nd Department of Pathology, Kurume University School of Medicine, Japan.
Nakamura
Y
Y
Nakano
R
R
Morimatsu
M
M
Fukuda
S
S
Nishimi
Y
Y
Hashimoto
T
T
D001344:Autopsy; D001842:Bone and Bones / Q000473:pathology; D002490:Central Nervous System / Q000473:pathology; D002869:Chromosome Aberrations / Q000473:pathology*; D025063:Chromosome Disorders; D002887:Chromosomes, Human, Pair 18; D004064:Digestive System / Q000473:pathology; D005260:Female; D006330:Heart Defects, Congenital / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000473:pathology; D008297:Male; D014314:Trisomy; D014566:Urogenital System / Q000473:pathology