[N-isopropyl I-123 p-iodoamphetamine (IMP) brain SPECT in Alzheimer's disease].
Eighteen patients with Alzheimer's disease (AD), 5 patients with Pick disease (PD), 6 patients with other types of degenerative dementia (O) and 12 age-matched normal control subjects (N) were studied using N-isopropyl p-[I-123]iodoamphetamine (I-123 IMP) with SPECT. Regional to cerebellar activity (R/CE) ratio and frontal to parietal (F/P) activity ratio were evaluated in each case. I-123 IMP-SPECT revealed focal abnormality in all cases in AD, PD, O group, while XCT and/or MRI were normal or showed cerebral atrophy without focal abnormal density or intensity. In AD group, R/CE ratio in all the regions except for bilateral Rolandic area and left primary visual cortex were significantly lower (p less than 0.05 or p less than 0.01) than that in N group, and F/P ratio were significantly higher (p less than 0.01) than that in P and O group. In conclusion, I-123 IMP-SPECT is useful to detect focal perfusion abnormality in dementia and may be of value in differentiating Alzheimer's disease from dementia of non-Alzheimer type.
Momose
T
T
Nishikawa
J
J
Kosaka
N
N
Ohtake
T
T
Watanabe
T
T
Yoshikawa
K
K
Iio
M
M
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging*; D003704:Dementia / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging
D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine