Pregnancy associated RPGN (rapidly progressive glomerulonephritis) with repeated attacks of purpura and arthralgia.
A 35-year-old woman at 28 weeks' gestation presented with purpura, arthralgia and proteinuria. After a skin biopsy had suggested necrotizing vasculitis, prednisolone was administered. Renal biopsy following delivery disclosed crescents in about 60% of glomeruli. After stopping prednisolone, purpuric lesions and arthralgia reappeared. A second renal biopsy demonstrated cellular crescents in about 80% of glomeruli. The symptoms disappeared on restarting prednisolone. However, the patient progressed to renal failure in 8 months. Histological examinations of the kidney and skin suggested microscopic PN.
Ishii
K
K
Kobayashi
M
M
Koyama
A
A
Narita
M
M
D000328:Adult; D001706:Biopsy; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007596:Joints / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000473:pathology; D010146:Pain / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications; D011693:Purpura / Q000209:etiology*; D012867:Skin / Q000473:pathology