title: Induction of murine macrophage fungal killing by interleukin 3.
abstract: The effect of recombinant interleukin 3 (IL-3) on the function of murine resident peritoneal macrophages was investigated. IL-3 enhanced the phagocytosis of Candida pseudotropicalis and Candida albicans and enhanced killing of the former. The enhanced killing is inhibited by scavengers of oxygen radicals, suggesting that IL-3 primes macrophages for enhanced oxidative metabolism in response to Candida.
authors: Department of Histology and Cell Biology, Sackler School of Medicine, Tel-Aviv University, Ramat-Aviv, Israel.
authors: I
authors: I
authors: Bleiberg
authors: Y
authors: Y
authors: Kletter
authors: I
authors: I
authors: Riklis
authors: I
authors: I
authors: Fabian
mesh_terms: D000818:Animals; D002175:Candida; D007377:Interleukin-3 / Q000494:pharmacology*; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000494:pharmacology
chemical_list: D007377:Interleukin-3; D013482:Superoxide Dismutase