title: Evidence for the production of an interleukin-like protein by Asterias rubens (axial organ cells) in mixed leukocyte cultures.
abstract: Cells from the axial organ of the sea star may be separated into two subpopulations, depending on adherence to nylon wool. The non-adherent cells are morphologically and physiologically similar to Th. lymphocytes and produce an MLR-like reaction in a xenogeneic system involving two different species of sea stars. On the second day of such a MLC, these cells released molecules which were probably glycoproteins and which produced a mitogenic effect on all the axial organ cells. No effect occurred when the supernatant was tested on adherent or non-adherent cells separately, suggesting that a cellular cooperation is necessary in order to produce the response. These soluble mediators produced by T-like cells with a mitogenic effect on lymphocyte-like cells resemble the interleukin proteins produced by vertebrate leukocytes.
authors: Laboratoire d'Immunologie des Invertébrés, Université d'Orléans, France.
authors: G
authors: G
authors: Luquet
authors: J
authors: J
authors: Lemaitre
authors: M
authors: M
authors: Leclerc
mesh_terms: D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D007378:Interleukins / Q000096:biosynthesis*; D007962:Leukocytes / Q000378:metabolism*; D008934:Mitogens / Q000096:biosynthesis; D013215:Starfish / Q000502:physiology*
chemical_list: D007378:Interleukins; D008934:Mitogens