Immunopathology of experimental autoallergic sialadenitis in C3H/He mice.
We have shown that autoallergic sialadenitis develops in C3H/He (H-2k) mice thymectomized 3 days after birth and then immunized at 4 or 6 weeks of age with a homogenate of the submandibular salivary gland emulsified in Freund's complete adjuvant. Significant inflammatory changes did not develop in other inbred strains, such as BALB/c (H-2d), and C57BL/6 (H-2b) mice, examined by the same experimental protocol, or in the control groups, i.e. animals thymectomized at day 3 but not immunized, and animals not thymectomized but immunized. The cellular infiltrates observed in C3H/He mice with sialadenitis consisted of small and medium-sized lymophocytes stained with anti-Thy-1.2 antibody (the major proportion positive with anti-L3T4 and the lesser, with anti-Lyt 2). Anti-salivary duct antibodies were detected frequently in the sera of the C3H/He mice with sialadenitis.
Hayashi
Y
Y
Department of Pathology, Tokyo Metropolitan Institute of Gerontology, Japan.
Hirokawa
K
K
D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D012466:Salivary Gland Diseases / Q000473:pathology*; D012793:Sialadenitis / Q000276:immunology / Q000473:pathology*; D013363:Submandibular Gland / Q000473:pathology; D013601:T-Lymphocytes / Q000145:classification; D013934:Thymectomy
D001323:Autoantibodies