Bone mass in Guamanian patients with amyotrophic lateral sclerosis and parkinsonism-dementia.
Bone mass, as assessed by measurements of total subperiosteal diameter and medullary width of the second metacarpal bone on hand-wrist radiographs, was evaluated for 31 Guamanian patients (15 males, 16 females) with amyotrophic lateral sclerosis (ALS), 67 patients (39 males, 28 females) with parkinsonism-dementia (PD), and 66 (34 males, 32 females) nonaffected Guamanian controls. Comparisons between the two disease groups and between each disease group and the nonaffected controls were made taking into account the sex, age, and disability status of each participant. At all ages, ALS patients of both sexes had significantly lower percent cortical areas (PCA) than did nonaffected controls. The ALS males also had significantly lower PCA than PD males, although no significant differences were observed between female ALS and PD patients. The PD patients of either sex had a lower PCA when compared to controls, but the differences were not statistically significant. The observed differences in PCA were due solely to increased medullary width, suggesting that the diminished cortical bone thickness resulted from greater bone resorption rather than differential bone growth. Longitudinal studies support the cross-sectional findings of accelerated bone loss among ALS patients. It is not possible to determine from the present data whether the observed differences in PCA of the second metacarpal of the ALS patients are due to atrophy of the first interosseous muscle, to a generalized resorption process inherently associated with the development and progression of ALS, or to factors not accounted for by the present analysis.
Garruto
R M
RM
Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892.
Plato
C C
CC
Yanagihara
R
R
Fox
K
K
Dutt
J
J
Gajdusek
D C
DC
Tobin
J
J
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000208:ethnology / Q000473:pathology*; D000704:Analysis of Variance; D001842:Bone and Bones / Q000473:pathology*; D005260:Female; D006141:Guam; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008663:Metacarpus / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D010300:Parkinson Disease / Q000208:ethnology / Q000473:pathology*; D011859:Radiography; D012044:Regression Analysis; D012737:Sex Factors