Dermatoses in five related female carriers of X-linked chronic granulomatous disease.
Eight female members of a family with X-linked chronic granulomatous disease were identified. Five were shown to be carriers of the disease gene. Each of these female carriers of the gene had a history of skin eruptions. The identification of the carrier state is important as genetic counselling should be offered and the prenatal diagnosis of this disorder is possible.
Garioch
J J
JJ
Department of Dermatology, Glasgow Royal Infirmary, Scotland, U.K.
Sampson
J R
JR
Seywright
M
M
Thomson
J
J
D000328:Adult; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods*; D008040:Genetic Linkage; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000235:genetics*; D006801:Humans; D010375:Pedigree; D012871:Skin Diseases / Q000209:etiology / Q000235:genetics*; D014960:X Chromosome