12-epi-teuscordonin and other neoclerodanes from Teucrium bicolor.
A new neoclerodane, (12R)-epi-teuscordonin [1] has been isolated from Teucrium bicolor. The boat conformation of ring B and the configuration at C-12 in 1 were established by nOe experiments. The known diterpenoids montanin C, teucvin, 12-epi-teucvin, teupolin I, 12-epi-teupolin I, and (12S)-teucrin H-2 were also isolated from the extract. Montanin C [2] was found to be moderately toxic in the brine shrimp bioassay.
Labbe
C
C
Universidad de Chile, Facultad de Ciencias, Departamento Química, Santiago.
Polanco
M I
MI
Castillo
M
M
D000818:Animals; D001156:Artemia; D055598:Chemical Phenomena; D002621:Chemistry; D002677:Chile; D004224:Diterpenes / Q000494:pharmacology* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000032:analysis*
D004224:Diterpenes; C061639:teuscordonin