[The effect of nucleotides and molybdate ions on the activation of glucocorticoid-receptor complexes].
The effects of various nucleotides and sodium molybdate on the activation of glucocorticoid-receptor complexes (GRC) isolated from tissue cytosol of 6- and 25-month-old rats was studied. It was shown that nucleoside triphosphates activate GRC in the livers of 6-month-old rats, the activating effect being decreased in the following order: UTP greater than or equal to ATP greater than GTP greater than or equal to CTP. Nucleoside di- and monophosphates exert a far lesser stimulating effect. These effects of nucleotides decrease with ageing. Molybdate ions exert a 3-fold effect on the activation of GRC from various rat tissues, i.e., stimulating, inhibiting and zero effects.
Konoplia
E F
EF
Luksha
G L
GL
D000375:Aging / Q000378:metabolism; D000818:Animals; D005938:Glucocorticoids / Q000378:metabolism*; D008297:Male; D008982:Molybdenum / Q000494:pharmacology*; D009711:Nucleotides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism*
D005938:Glucocorticoids; D009711:Nucleotides; D011965:Receptors, Glucocorticoid; D008982:Molybdenum
Vliianie nukleotidov i ionov molibdata na aktivatsiiu gliukokortikoid-retseptornykh kompleksov.