[The pharmacokinetics of SC1001-sodium and SC1001-aminum in human body].
The pharmacokinetics of SC1001-Sodium and SC1001-Aminum in the human body was studied. After 200 mg SC1001-Sodium or SC1001-Aminum by oral administration, plasma concentration-time data were fitted to curves by means of the nonlinear least-square method, employing the program we ourselves compiled. With F-test, comparing gamma 2(1) -value and AIC-value, the linear one compartment open model was available. The mean pharmacokinetic parameters fitted one by one were as follows with the first value given belonging to SC1001-Sodium and the second to SC1001-Aminum: Ka: 0.7248 and 0.5102 h-1; Ke: 0.0597 and 0.1149 h-1; T1/2, a: 1.1437 and 1.8999 h; T1/2, e: 15.7428 and 6.1497 h; AUC: 600.15 and 28.61 micrograms.h/ml; Tm: 4.4798 and 4.3728h.
Zhu
Q D
QD
Xia
D L
DL
Li
W N
WN
D000284:Administration, Oral; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D002934:Cinnamates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male
D002934:Cinnamates; C058003:SC 1001A