The effect of chronic atropine administration on mouse motility and on ACh levels in the central nervous system.
Changes in mouse motility and CNS cortical and subcortical ACh levels were studied after chronic (20 days) administration of 30, 40 and 60 mg/kg/day atropine. An increase in motility similar to that induced by acute atropine administration was observed, whereas the ACh levels reduction caused by acute administration was not repeated. These results suggest that changes in mouse motility caused by atropine are not correlated to its modification of ACh levels in the CNS.
Molinengo
L
L
Institute of Pharmacology and Pharmacognosy, University of Turin, Torino, Italy.
Fundarò
A
A
Orsetti
M
M
D000109:Acetylcholine / Q000032:analysis* / Q000378:metabolism; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects*; D002540:Cerebral Cortex / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*
D001285:Atropine; D000109:Acetylcholine