[Microiontophoretic study of the effect of cholinergic substances on the activity of medullary respiratory neurons].
The responses of single inspiratory, expiratory and unspecific neurons of the medulla oblongata to microelectrophoretic applications of acetylcholine, M- and N-cholinergic-blocking agents (atropine and etpenal) were studied in anesthetized cats. A relatively small amount of cholinoreactive neurons was found. Cholinoreactive units prevailed in the group of unspecific neurons. Electrophoretic application of acetylcholine evoked mainly excitatory responses. A rather mild inhibitory action of anticholinergic drugs on neurons of bulbar respiratory centre was revealed. These reactions seem to be unspecific being evoked in acetylcholine-sensitive and nonsensitive neurons.
Nersesian
L B
LB
Baklavadzhian
O G
OG
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology; D001561:Benzilates / Q000008:administration & dosage / Q000494:pharmacology; D002415:Cats; D007478:Iontophoresis; D008526:Medulla Oblongata / Q000187:drug effects* / Q000502:physiology; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010276:Parasympatholytics / Q000008:administration & dosage* / Q000494:pharmacology; D012125:Respiratory Center / Q000187:drug effects* / Q000502:physiology
D001561:Benzilates; D010276:Parasympatholytics; C014538:ethpenal; D001285:Atropine; D000109:Acetylcholine
Mikroionoforeticheskoe issledovanie vliianiia kholinergicheskikh veshchestv na aktivnost' medullianykh dykhatel'nykh neĭronov.