Hypogammaglobulinemia in infants infected with human immunodeficiency virus.
Two premature infants were infected with HIV via blood transfusions during the neonatal period. Although neither patient had serum antibody to HIV owing to severe hypogammaglobulinemia, HIV infection was confirmed by finding HIV antigen in the sera of both patients. These cases show that HIV infection can produce severe hypogammaglobulinemia, and illustrate the value of HIV antigen detection in the diagnosis of HIV infection in seronegative patients.
Saulsbury
F T
FT
Department of Pediatrics, University of Virginia Medical Center, Charlottesville 22908.
D004406:Dysgammaglobulinemia / Q000209:etiology*; D017707:Erythrocyte Transfusion; D005260:Female; D015488:HIV Antigens / Q000032:analysis; D006679:HIV Seropositivity / Q000150:complications* / Q000276:immunology; D006801:Humans; D017098:IgA Deficiency; D017099:IgG Deficiency; D007075:Immunoglobulin M / Q000172:deficiency*; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000150:complications*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology; D065227:Transfusion Reaction
D015488:HIV Antigens; D007075:Immunoglobulin M