[Bone diffusion of cefotiam in men].
A 2g single dose of cefotiam was given by rapid intravenous injection to 17 patients undergoing total hip replacement as a prophylaxis. The concentrations of the antibiotic in plasma and femoral head (cancellous bone, cortical bone and capsule) were measured at different time (40 to 250 minutes) following the injection of the drug. Evaluation was done by liquid chromatography. Mean antibiotic concentrations were 70.5 micrograms/ml, 41.4 micrograms/g, 16.9 micrograms/g and 8.1 micrograms/g respectively in plasma, capsule, cancellous and cortical bones. 240 minutes following the injection, mean concentrations of cefotiam were higher than 2.3 micrograms/ml in plasma and 1.8 micrograms/g in bone. Diffusion in cancellous bone is twofold high as in cortical bone and elimination half lif is higher in bone than in plasma (248.8 minutes versus 59.6 minutes in plasma). These results suggest that a 2g intravenous bolus injection of cefotiam given at the induction of anaesthesia should provide an effective prophylaxis during total hip replacement.
Farinotti
R
R
Département de Pharmacie Clinique, Faculté de Pharmacie, Centre Hospitalier Universitaire Xavier-Bichat, Hôpital Claude-Bernard, Paris.
Vie
P
P
Montes
C
C
Cavagna
R
R
Rosembaum
M
M
Duparc
J
J
D000042:Absorption; D000327:Adsorption; D000368:Aged; D001842:Bone and Bones / Q000378:metabolism*; D015310:Cefotiam / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004058:Diffusion; D006622:Hip Prosthesis; D006801:Humans; D008875:Middle Aged; D011292:Premedication
D015310:Cefotiam
Etude de la diffusion osseuse du céfotiam chez l'homme.