Effects of compensated heart failure on digoxin pharmacokinetics in cats.
To evaluate the effects of compensated heart failure (HF) on digoxin pharmacokinetic properties in cats, 6 cats with dilated cardiomyopathy were compared with 6 clinically normal (control) cats. Digoxin tablets were administered at a dosage of 0.01 mg/kg of body weight, q 48 h for approximately 10 days, until presumed steady state was reached. Both groups were treated concomitantly with aspirin, furosemide, and a commercial low-salt diet. Retrospectively, control and HF cats were calculated to be at 95% and 97% steady state, respectively. At the time blood samples were collected, HF cats were clinically compensated. Serum digoxin concentration [( DXN]) was determined by radioimmunoassay on samples drawn immediately before and 1, 2, 4, 8, 12, 24, 34, and 48 hours after digoxin administration. Measured and calculated values (peak, 8-hour, and mean [DXN]; elimination half-life [t1/2]; oral clearance; and hours during which [DXN] was in the toxic range) were not significantly different between control and HF cats. To predict individual propensity for digoxin intoxication, serum creatinine and urea concentrations and sulfobromophthalein dye retention were measured in control and HF cats prior to the onset of treatment with digoxin. There was no statistically significant correlation between serum creatinine and urea concentrations when compared with sulfobromophthalein dye retention nor between any of these values and digoxin peak, 8-hour, and mean concentrations or t1/2, oral clearance, or hours during which [DXN] was in the toxic range. Mean serum creatinine and urea nitrogen concentrations were significantly greater (P less than 0.01) and sulfobromophthalein dye retention approached significant prolongation (P less than 0.06) in HF cats, compared with that in control cats.(ABSTRACT TRUNCATED AT 250 WORDS)
Atkins
C E
CE
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
Snyder
P S
PS
Keene
B W
BW
Rush
J E
JE
D000818:Animals; D001806:Blood Urea Nitrogen; D002311:Cardiomyopathy, Dilated / Q000378:metabolism / Q000662:veterinary*; D002371:Cat Diseases / Q000378:metabolism*; D002415:Cats; D003404:Creatinine / Q000097:blood; D004077:Digoxin / Q000493:pharmacokinetics*; D005260:Female; D008297:Male
D004077:Digoxin; D003404:Creatinine