ICRC mouse with congenital mega-esophagus as a model to study esophageal tumorigenesis.
ICRC mouse, an inbred strain, developed at the Cancer Research Institute, Bombay, exhibits mega-esophagus with markedly hyperplastic mucosa. Diethylnitrosamine (DEN) when given in drinking water at the dose of 4 mg/kg body weight/day, induced esophageal papillomas consistently in 100% of the animals, in a short period of 12 weeks. Further, tumors were produced, even at a very low cumulative dose of 28 mg/kg body weight. Development of the esophageal papillomas was dose dependent. DEN even induces esophageal tumors transplacentally in the ICRC F1 progeny. Tobacco acts predominantly as a promoter in this system. ICRC mouse thus provides a much needed animal model to study esophageal tumorigenesis, including the two-stage carcinogenesis. An interesting feature of the study is that initiation could be induced by exposure to low doses of DEN in the intra-uterine life. Tumors develop in such F1 animals only if they are fed tobacco, a predominant promoter, post-natally.
Ghaisas
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Cell and Developmental Pathology Division, Tata Memorial Centre, Parel, Bombay, India.
Saranath
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Deo
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MG
D000375:Aging; D000818:Animals; D004052:Diethylnitrosamine / Q000633:toxicity; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000473:pathology*; D004947:Esophagus / Q000002:abnormalities* / Q000254:growth & development / Q000473:pathology; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D010212:Papilloma / Q000139:chemically induced / Q000473:pathology*
D004052:Diethylnitrosamine