[Calciotropic hormones in osteoporosis caused by anorexia nervosa].
The authors evaluated bone mineralization by single photon absorptiometry and mineral homeostasis in 7 patients with anorexia nervosa. The patients with anorexia nervosa showed a reduction of bone mineralization in respect to age-sex matched normal values. Serum levels of calcium, ionized calcium, phosphate, magnesium, alkaline phosphatase, calcitonin and 25-hydroxyvitamin D were normal as well as phosphate and hydroxyproline urinary excretion. Osteocalcin levels were significantly low as compared to normal values (5.0 +/- 3.0 ng/ml vs 14.3 +/- 5.2 ng/ml, p less than 0.01) as well as urinary calcium excretion (0.02 +/- 1.01 vs 0.08 +/- 0.06, p less than 0.05); 1,25-dihydroxyvitamin D values were low only in 4 patients. Parathyroid hormone means levels were increased in respect to normal values (74.1 +/- 12.7 pg/ml vs 38.0 +/- 12.0, p less than 0.02). We confirm that adolescents with anorexia nervosa showed a reduced bone mineral content and alterations of mineral homeostasis that may contribute to the development of bone mineral loss.
Saggese
G
G
Bertelloni
S
S
Baroncelli
G I
GI
Ghirri
P
P
Cosenza
G M
GM
Buggiani
B
B
D015055:1-Carboxyglutamic Acid / Q000097:blood; D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications*; D001842:Bone and Bones / Q000378:metabolism*; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000097:blood; D002648:Child; D005260:Female; D006706:Homeostasis; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood; D008297:Male; D008903:Minerals / Q000378:metabolism; D015675:Osteocalcin; D010024:Osteoporosis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood; D014812:Vitamin K / Q000097:blood
D002135:Calcium-Binding Proteins; D006887:Hydroxycholecalciferols; D008903:Minerals; D010281:Parathyroid Hormone; D015675:Osteocalcin; D014812:Vitamin K; D015055:1-Carboxyglutamic Acid; D002116:Calcitonin; D002118:Calcium
Ormoni calciotropi nell'osteoporosi dell'anoressia nervosa.