title: Cytotoxic isoquinoline alkaloids from Xanthorhiza simplicissima.
abstract: Two cytotoxic isoquinoline alkaloids, liriodenine and palmatine, were isolated from the Xanthorhiza simplicissima Marsh. Liriodenine, isolated for the second time from the family of Ranunculaceae, demonstrated potent cytotoxicity against KB, A-549, HCT-8, P-388, and L-1210 tumor cells, while palmatine showed marginal cytotoxicity against KB cells.
authors: Y C
authors: YC
authors: Wu
authors: T
authors: T
authors: Yamagishi
authors: K H
authors: KH
authors: Lee
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D001060:Aporphines / Q000494:pharmacology; D001600:Berberine Alkaloids / Q000494:pharmacology; D006801:Humans; D051379:Mice
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; D001600:Berberine Alkaloids; C026980:liriodenine; C005413:palmatine