[A long-surviving case of gastric cancer with peritoneal metastasis (P3) responding to short-term high-dose chemotherapy and long-term immunotherapy].
A 37-year-old female was admitted to our hospital for further examination of epigastralgia. She was diagnosed as having multiple metastases due to advanced gastric cancer (Borrmann type 3). The operative findings showed bilateral ovarian (Krukenberg), Schnitzler and widespread peritoneal metastases involving the appendix (P3H0N2S2). She underwent total gastrectomy, splenectomy, bilateral oophorectomy, and appendectomy with CDDP (100 mg intraperitoneal administration). After operation, CDDP (50 mg/body, twice i.p. and once i.v.) and PSK (3.0 g/day) were administered. She has been followed in our outpatient department for 3 years without any recurrence. The findings suggest that combination therapy using short-term high-dose chemotherapy and long-term immunotherapy can be effective for such cases.
Kusama
M
M
Dept. of Surgery, Tokyo Medical College.
Kimura
K
K
Suzuki
K
K
Fukaya
Y
Y
Saitoh
S
S
Eiraku
H
H
Kawahara
S
S
Ueno
M
M
Kawaguchi
M
M
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000627:therapeutic use; D000328:Adult; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000628:therapy; D011379:Prognosis; D011509:Proteoglycans / Q000008:administration & dosage* / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*
D000276:Adjuvants, Immunologic; D011509:Proteoglycans; C010770:polysaccharide-K; D002945:Cisplatin