Calcitonin gene-related peptide (CGRP) in normotensive and spontaneously hypertensive rats.
With the techniques of specific radioimmunoassay and gel filtration it was found that CGRP was distributed in various tissues of normotensive (WKY) and spontaneously hypertensive rats (SHR) with the highest concentration in the lumbar spinal cord (1197 +/- 94.8 pg/mg tissue) and the lowest in the auricle (15.0 +/- 2.1 pg/mg tissue). In comparison with WKY, CGRP concentration in the plasma was decreased and in the abdominal aorta and hypothalamus was increased in SHR. Gel filtration revealed only one major CGRP molecular form in the tissues. In addition, CGRP reduced the mean arterial pressure (MAP) in SHR in a dose-dependent manner. These data suggest that CGRP may play an important role in the pathogenesis of hypertension and its possible therapy.
Xu
D
D
Laboratory of Cardiopulmonary Endocrinology, Beijing Medical University, P.R. China.
Wang
X A
XA
Wang
J P
JP
Yuan
Q X
QX
Fiscus
R R
RR
Chang
J K
JK
Tang
J A
JA
D000818:Animals; D001012:Aorta, Abdominal / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D002116:Calcitonin / Q000032:analysis*; D015740:Calcitonin Gene-Related Peptide; D006339:Heart Rate / Q000187:drug effects; D007031:Hypothalamus / Q000032:analysis; D009131:Muscle, Smooth, Vascular / Q000032:analysis; D009206:Myocardium / Q000032:analysis; D009479:Neuropeptides / Q000032:analysis* / Q000097:blood / Q000494:pharmacology; D009928:Organ Specificity; D011863:Radioimmunoassay; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism*; D011919:Rats, Inbred Strains / Q000378:metabolism*; D011921:Rats, Inbred WKY / Q000378:metabolism; D012016:Reference Values; D013116:Spinal Cord / Q000032:analysis
D009479:Neuropeptides; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide