[Nephrotoxicity and myelotoxicity of antineoplastic Pt(II) and Pt(IV) coordination compounds in rats].
In comparison with cis-DDP four new platinum (II) and platinum (IV) complexes were evaluated for their acute nephrotoxic and myelotoxic potency in male rats following i.v. administration of maximum tolerated doses on 5 consecutive days. Parameters for nephrotoxicity determined on day 6, 13 and 22 after the first administration of the drugs included blood, urea nitrogen, serum creatinine, urine volume, urinary glucose and tubule cell excretion. Parameters for myelotoxicity determined on the same days included leucocytes, platelets, hemoglobin and hematocrit. Cis-DDP was found to be the most nephrotoxic compound. The myelotoxicity of the new platinum complexes appeared to be similar to that of cis-DDP with exception of trans-ODDP.
Horn
U
U
Zentralinstitut für Mikrobiologie und experimentelle Therapie, Akademie der Wissenschaften der DDR, Jena.
Härtl
A
A
Neuhaus
G
G
Stöckel
U
U
Schröer
H P
HP
Hoffmann
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002945:Cisplatin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000633:toxicity*; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects*; D008297:Male; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C061259:diammine platinum(II) dilactate; C061258:diammine platinum(II) lactate; D002945:Cisplatin; C043804:diamminedichlorodihydroxyplatinum IV
Nephrotoxizität und Myelotoxizität antineoplastisch wirksamer Pt(II)- und Pt(IV)-Koordinationsverbindungen bei Ratten.