Cholinergic and noradrenergic toxicity of intraventricular aluminum chloride in the rat hippocampus.
The effects of the intraventricular administration of aluminum chloride (AlCl3) on high affinity choline transport (HAChT) and norepinephrine concentration were examined in the hippocampus of the rat. Controlling for osmolarity and pH, the intraventricular administration of AlCl3 resulted in a dose-related reduction in both variables with relative selectivity for HAChT. Moreover, the neurotoxicity of intraventricular aluminum appeared to be dependent on the forms of the aluminum salt administered.
Zubenko
G S
GS
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213.
Hanin
I
I
D000535:Aluminum / Q000506:poisoning*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002552:Cerebral Ventricles / Q000502:physiology*; D002712:Chlorides / Q000506:poisoning*; D002794:Choline / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D007276:Injections, Intraventricular; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000378:metabolism
D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride; D000535:Aluminum; D002794:Choline; D009638:Norepinephrine