title: Biocompatibility of human collagen type IV intracorneal implants.
abstract: A new biomaterial made from human placental collagen type IV has been developed in corneal inlays for refractive keratoplasty. Eight dogs received intracorneal lenses to investigate biocompatibility. Postoperative follow-up observation of 2 years revealed that the eyes remained clear and without inflammatory reaction. Endothelial cells were unaltered. Histological and ultrastructural studies showed no signs of inflammation, ulceration, or encapsulation. No fibroblastic activity was evident at the lens stroma interface.
authors: Laboratoires Biodomi, Saint-Just-Chaleyssin, France.
authors: D
authors: D
authors: Dupont
authors: P
authors: P
authors: Gravagna
authors: P
authors: P
authors: Albinet
authors: J L
authors: JL
authors: Tayot
authors: J P
authors: JP
authors: Romanet
authors: M
authors: M
authors: Mouillon
authors: R
authors: R
authors: Eloy
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D003094:Collagen / Q000276:immunology*; D003315:Cornea / Q000276:immunology / Q000601:surgery* / Q000648:ultrastructure; D004285:Dogs; D004728:Endothelium, Corneal / Q000648:ultrastructure; D005500:Follow-Up Studies; D006085:Graft Survival; D008422:Materials Testing; D019736:Prostheses and Implants
chemical_list: D001672:Biocompatible Materials; D003094:Collagen