Effect of recombinant human granulocyte colony-stimulating factor on Pneumocystis carinii infection in nude mice.
Repeated subcutaneous (s.c.) injections of recombinant human granulocyte colony-stimulating factor (rhG-CSF) to Pneumocystis carinii (P. carinii)-infected balb/c nude (nu/nu) mice had no effects on the number of the P. carinii cysts in the lungs, despite neutrophilic infiltration in the tissues and a marked increase in blood neutrophil count. This finding indicates that neutrophils in the absence of T cells do not play an important role in the killing of P. carinii. However, survival periods of the rhG-CSF treated mice seemed to extend to some extent compared with the controls presumably because of the prevention of mixed bacterial infections.
Ieki
R
R
3rd Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Furuta
T
T
Asano
S
S
Mori
S
S
Kudoh
S
S
Kimura
H
H
Takaku
F
F
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D005260:Female; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008168:Lung / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D011010:Pneumocystis / Q000187:drug effects; D011020:Pneumonia, Pneumocystis / Q000276:immunology* / Q000473:pathology; D011994:Recombinant Proteins / Q000494:pharmacology
D003115:Colony-Stimulating Factors; D011994:Recombinant Proteins