title: Lineage relationship between oligodendrocytes and brain macrophages?
abstract: Cells which adhere rapidly in vitro were purified from embryonic rat brain and characterized as macrophages. These characterizations rely on (1) phagocytic behaviour, (2) non-specific esterase activity, (3) immunocytochemical criteria such as the detection of CD4, Mac 1 and class II products of the major histocompatibility complex (MHC II). Morphological transformations observed in the cultures and labeling with anti-galactocerebroside (GalC) antibodies suggest a possible transition between brain-macrophagic and oligodendrocytic phenotypes.
authors: Chaire de Neuropharmacologie, INSERM U.114, Collège de France, Paris.
authors: M
authors: M
authors: Mallat
authors: B
authors: B
authors: Chamak
mesh_terms: D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism; D002455:Cell Division; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology* / Q000378:metabolism; D003342:Corpus Striatum / Q000166:cytology* / Q000378:metabolism; D004622:Embryo, Mammalian; D006649:Histocompatibility Antigens / Q000378:metabolism; D008264:Macrophages / Q000166:cytology* / Q000378:metabolism; D009457:Neuroglia / Q000166:cytology*; D009836:Oligodendroglia / Q000166:cytology* / Q000378:metabolism; D051381:Rats
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D006649:Histocompatibility Antigens