Differential endocytosis of IgM and IgD in murine B cell lines.
The internalization of surface immunoglobulin (Ig) by B lymphocytes is the first step in the antigen-presenting function performed by these cells. Mature B cells coexpress on their surface IgM and IgD. At this time, there is controversy over whether these two isotypes serve different functions in the antigen-presenting process. The results presented here show that the intracellular pattern of distribution of IgM and IgD after internalization is strikingly different in the B cell lines studied. These findings support the hypothesis that the role of the two Ig classes in the antigen-presenting function may be different.
Guarini
L
L
Division of Pediatric Hematology-Oncology, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
Weber
D A
DA
Pernis
B
B
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D002460:Cell Line; D003432:Cross-Linking Reagents; D004705:Endocytosis; D007072:Immunoglobulin D / Q000378:metabolism*; D007075:Immunoglobulin M / Q000378:metabolism*; D066298:In Vitro Techniques; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*
D003432:Cross-Linking Reagents; D007072:Immunoglobulin D; D007075:Immunoglobulin M; D008565:Membrane Proteins; D011947:Receptors, Antigen, B-Cell