Effects of alpha- and beta-calcitonin gene-related peptides upon ion transport in rat descending colon.
Both alpha- and beta-calcitonin gene-related peptide (CGRP) exhibit concentration-dependent dual actions upon rat colonic epithelia. At low concentrations (i.e. 0.03-10 nM) both CGRPs produce antisecretory effects that are abolished by pretreating tissues with tetrodotoxin (TTX). At higher concentrations (30-200 nM) secretory responses predominate and these effects are not abolished by TTX. It is suggested that the mediator of the antisecretory actions of CGRPs is somatostatin.
Cox
H M
HM
Department of Pharmacology, University of Cambridge.
Ferrar
J A
JA
Cuthbert
A W
AW
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D007477:Ions; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013779:Tetrodotoxin / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*
D007477:Ions; D014665:Vasodilator Agents; D013779:Tetrodotoxin; D015740:Calcitonin Gene-Related Peptide