[Basal studies on combination of Chinese medicine in cancer chemotherapy: protective effects on the toxic side effects of CDDP and antitumor effects with CDDP on murine bladder tumor (MBT-2)].
Effects of oral administration of Juzentaihoto, a herb drug, on the toxic side effects of cis-diammine dichloroplatinum (CDDP) and combination effects with CDDP on murine bladder tumor (MBT 2) were studied using C3H/He male mice. The following results were obtained; 1. When the mice were treated with the mixture diet of 1% or 0.5% Juzentaihoto before 2 weeks, adverse effects of high dose CDDP (15 or 17.5 mg/kg) which were included with lethal toxicity, renal and hepatic toxicity, and myelosuppression were protected significantly. The administration of 0.5% Juzentaihoto mixture diet markedly shifted the LD50 to the right. Furthermore, the effects of Juzentaihoto were clearly revealed on the histological findings of testis and kidney. 2. On murine bladder tumor, when the mice were treated with the mixture diet of 1% or 0.5% Juzentaihoto and injected CDDP (2.5 mg/kg/week) for 8 weeks, significantly greater inhibition of the tumor growth and prolongation of the survival rate were observed than those in the group of CDDP alone. These results indicates that Juzentaihoto lessens the toxic side effects of CDDP and that it enhances the effects of CDDP experimentally. Juzentaihoto, a kind of Chinese herb medicine, might come under the category of biological response modifiers.
Ebisuno
S
S
Hirano
A
A
Kyoku
I
I
Ohkawa
T
T
Iijima
O
O
Fujii
Y
Y
Hosoya
E
E
D000284:Administration, Oral; D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D002945:Cisplatin