[The effect of autoplasma of patients with breast cancer on the functional activity of natural killer cells and adhering mononuclear cells in peripheral blood in vitro].
Autoplasma of 43 breast cancer patients and 30 donors has been studied for its effect on the activity of natural killer (NK) cells and adherent cells phagocytosis. The cytotoxic activity of NK cells and the phagocytic activity of adherent cells as well as the cytotoxic activity of plasma of breast cancer patients toward K-562 cells are found to increase during tumour progression. Autoplasma of cancer patients is shown to block the cytotoxic activity of NK and even more markedly--the phagocytic activity of adherent cells. As a result, breast cancer patients have nearly normal level of the cytotoxic activity of NK in the presence of autoplasma, whereas the phagocytic activity of adherent mononuclears decreases. Thus, autoplasma of breast cancer patients properly affects the cytotoxic activity of the NK cells and the phagocytic activity of adherent cells.
Andrianov
I G
IG
Katashkova
T N
TN
D001943:Breast Neoplasms / Q000097:blood* / Q000628:therapy; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000637:transplantation; D010587:Phagocytosis
Vliianie autoplazmy bol'nykh rakom molochnoĭ zhelezy na funktsional'nogo aktivnost' estestvennykh killernykh kletok i prilipaiushchikh mononuklearov perifericheskoĭ krovi in vitro.