title: Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents.
abstract: The preparation and biological activities of a series of pyrido[3,4-e]-1,2,4-triazines, 1,2,4-triazino[5,6-c]quinolines, and related fused triazines are described. Methyl, amino, and acylamino substituents were placed in the pyridyl ring of the former system. Other structural modifications included various alkyl, cycloalkyl, substituted phenyl, and heterocyclic groups in the 3-position of these ring systems. In agar dilution assays, actives in this series inhibited strains of Candida, Aspergillus, Mucor, and Trychophyton species at MIC's of less than or equal to 16 micrograms/mL.
authors: Infectious Diseases and Molecular Biology Research Section, American Cyanamid Company, Pearl River, New York 10965.
authors: M F
authors: MF
authors: Reich
authors: P F
authors: PF
authors: Fabio
authors: V J
authors: VJ
authors: Lee
authors: N A
authors: NA
authors: Kuck
authors: R T
authors: RT
authors: Testa
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D011804:Quinolines / Q000138:chemical synthesis / Q000494:pharmacology*; D014227:Triazines / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D006571:Heterocyclic Compounds; D011725:Pyridines; D011804:Quinolines; D014227:Triazines; C023666:pyridine