Neonatal lupus in twins.
Neonatal lupus erythematosus (NLE) is a syndrome characterized by one or all of the following elements: cutaneous LE lesions, systemic disease, and congenital heart block. SS-A/Ro and SS-B/La have been implicated in the etiology of NLE, but because NLE is not uniformly manifested in all offspring of SS-A and SS-B autoantibody positive mothers, and because of the wide range of clinical manifestations associated with NLE, other contributing etiologic factors are being explored. HLA studies have revealed that infants of SS-A/Ro and SS-B/La positive mothers bearing HLA-A1, B8, DR3, DQ2, and DR52 are at greater risk of having NLE. Haplotyping in our dizygous twins supports these material HLA associations.
Lawrence
N
N
Department of Dermatology, Tulane Medical School, New Orleans, LA 70112.
Bligard
C A
CA
Storer
J
J
Courregé
M L
ML
D000974:Antibodies, Antinuclear / Q000235:genetics; D004200:Diseases in Twins; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes; D006327:Heart Block / Q000151:congenital*; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D008178:Lupus Erythematosus, Cutaneous / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D013577:Syndrome; D014429:Twins, Dizygotic
D000974:Antibodies, Antinuclear; D006680:HLA Antigens