Prevention of hyperthermia-induced seizures in immature rats by a hydantoin derivative of naloxone.
The non-specific opiate antagonist naloxone protects immature rats from hyperthermic seizures which occur when the animals are exposed to an environment of 40 degrees C and 55% humidity. Most of the currently used antiepileptic therapeutic agents can be said to contain either a hydantoin or a moiety stereochemically closely related to one. We have added a hydantoin group to naloxone and created a new combined chemical, naloxyl-6-alpha spirohydantoin. The new compound was ten times as effective as naloxone against hyperthermic seizures in 15-day old rat pups. Unlike naloxone, the new naloxone-hydantoin derivative retained a protective effect 24 hrs after injection.
Chatterjie
N
N
Institute for Basic Research in Developmental Disabilities, New York State Office of Mental Retardation and Developmental Disabilities, Staten Island 10314.
Laorden
M L
ML
Puig
M M
MM
Alexander
G J
GJ
D000818:Animals; D001831:Body Temperature; D004780:Environment, Controlled; D005334:Fever / Q000401:mortality / Q000517:prevention & control; D006827:Hydantoins / Q000494:pharmacology*; D006979:Hyperthermia, Induced; D009270:Naloxone / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000401:mortality / Q000517:prevention & control*; D012965:Sodium Chloride
D006827:Hydantoins; D009270:Naloxone; D012965:Sodium Chloride