title: Attenuation of the febrile response in guinea pigs by fish oil enriched diets.
abstract: The influence of dietary lipid manipulation on the fever response to an injection of murine recombinant Interleukin-1 (rIL-1) in guinea pigs was examined. The animals were fed diets identical except for the lipid source for periods of 5 and 6 wk. In vitro thromboxane B2/B3 (TxB2/B3) production in collagen-stimulated whole blood was also measured. One diet was enriched with menhaden oil, high in the omega-3 series of fatty acids. The other diet contained safflower oil, consisting primarily of the omega-6 fatty acid linoleic acid (74%). Animals fed the fish oil-enriched diet for 6 wk not 5 week had a blunted fever response after rIL-1 injection. This was associated with a 27% increase (p less than 0.05) in total omega-3 fatty acids in plasma phospholipids between weeks 5 and 6 in fish oil-fed animals. Safflower oil-fed animals produced a "normal" febrile response regardless of the duration of feeding. Safflower-fed guinea pigs demonstrated a significant increase in TxB2/B3 production in whole blood after 6 wks that was associated with a 25% increase (p less than 0.05) in plasma phospholipid arachidonic acid levels between weeks 5 and 6. Despite significant reductions in phospholipid linoleic acid in animals fed fish oil, arachidonic acid levels remained unchanged. In the guinea pig model used, long-term menhaden oil feeding can significantly blunt the febrile response induced by exogenous Interleukin-1. Also, a high intake of linoleic acid as seen in safflower oil feeding can significantly increase thromboxane production in stimulated whole blood.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Laboratory of Nutrition and Infection, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215.
authors: J J
authors: JJ
authors: Pomposelli
authors: E A
authors: EA
authors: Mascioli
authors: B R
authors: BR
authors: Bistrian
authors: S M
authors: SM
authors: Lopes
authors: G L
authors: GL
authors: Blackburn
mesh_terms: D000818:Animals; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D005395:Fish Oils / Q000494:pharmacology*; D005527:Food, Fortified; D006168:Guinea Pigs; D007375:Interleukin-1 / Q000008:administration & dosage; D010743:Phospholipids / Q000097:blood; D012450:Safflower Oil / Q000494:pharmacology; D013929:Thromboxane B2 / Q000096:biosynthesis; D013931:Thromboxanes / Q000096:biosynthesis
chemical_list: D005395:Fish Oils; D007375:Interleukin-1; D010743:Phospholipids; D013931:Thromboxanes; D013929:Thromboxane B2; D012450:Safflower Oil