[Liver function of patients with arterial hypoxemia in chronic obstructive respiratory tract disease and the effect of nasal oxygen insufflation].
Patients suffering from chronic obstructive airway disease often have arterial hypoxemia, which is more or less severe. If hypoxemia deteriorates the function of the liver is still unknown. The aim of this study was to determine, if a mostly oxygen dependent process of liver metabolism (galactose elimination capacity) is disturbed and if it can be increased by oxygen insufflation. Under the same conditions an oxygen independent process (indocyaninegreen clearance) should not be influenced. Our results show, that galactose elimination capacity under room air was pathologic and can be increased significantly by oxygen breathing. No change of indocyaninegreen clearance was seen under the same conditions. After termination of oxygen therapy the galactose elimination capacity was as bad as before oxygen breathing. Dysfunctions of the liver, which are caused by hypoxemia, can be positively influenced by oxygen, but only for the duration of oxygen insufflation.
Micklefield
G H
GH
Abteilung für Gastroenterologie und Hepatologie Medizinischen Universitätsklinik Bergmannsheil, Bochum.
Schött
D
D
Kuntz
H D
HD
May
B
B
Ulmer
W T
WT
D000368:Aged; D005260:Female; D005690:Galactose; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D007208:Indocyanine Green; D008099:Liver / Q000503:physiopathology; D008111:Liver Function Tests; D008173:Lung Diseases, Obstructive / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy
D007208:Indocyanine Green; D005690:Galactose
Leberfunktion von Patienten mit arterieller Hypoxämie bei chronisch obstruktiver Atemwegserkrankung und der Einfluss der nasalen Sauerstoffinsufflation.