[Immunologic variants of acute lymphoblastic leukemia in adults and its correlation with cytochemical and various clinical parameters].
The authors provide data pertaining to the immunological phenotyping in the panel of monoclonal antibodies to various differentiating antigens of the leukemic cells in 27 patients with acute lymphoblastic leukemia (ALL). Based on the composition of the differentiating antigens of the leukemic cells the following immunological variants of the disease were identified: pre-B, pre-T and T-ALL--the thymic and mature (activated) ones. The phenotype was compared with the cytochemical parameters of the lymphoblasts of the identified immunological variants of ALL and with some clinical and hematological manifestations of the disease. The comparison of the data obtained during blast cell immunophenotyping with the cytochemical parameters and some clinicohematological findings suggests the development of a more fundamental classification of ALL in order to perfect the treatment of the patients suffering from ALL.
Bulycheva
T I
TI
Novikova
M S
MS
Miterev
G Iu
GIu
Shakhbazian
G P
GP
Novikova
N N
NN
D000293:Adolescent; D000328:Adult; D000368:Aged; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
D000944:Antigens, Differentiation, B-Lymphocyte; D000945:Antigens, Differentiation, T-Lymphocyte
Immunologicheskie varianty ostrogo limfoblastnogo leĭkoza vzroslykh v sopostavlenii s tsitochimicheskimi i nekotorymi klinicheskimi parametrami.