The effect of immunotoxin against human glioma cells.
The authors produced immunotoxin by coupling the diphtheria toxin fragment A to the monoclonal antibody against a human glioma cell line. This toxin selectively inhibited protein synthesis of glioma cells in culture.
Manome
Y
Y
Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan.
Watanabe
M
M
Ohno
T
T
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000918:Antibody Specificity; D001932:Brain Neoplasms / Q000276:immunology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004167:Diphtheria Toxin / Q000627:therapeutic use*; D005910:Glioma / Q000276:immunology; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000911:Antibodies, Monoclonal; D004167:Diphtheria Toxin; D000922:Immunotoxins; D010446:Peptide Fragments; C029795:diphtheria toxin fragment A