Physiological pharmacokinetic model of adriamycin delivered via magnetic albumin microspheres in the rat.
The influence of magnetic albumin microspheres on the disposition of adriamycin was evaluated. Adriamycin concentrations were monitored in multiple rat tissues for 48 hr after its intra-arterial administration (2 mg/kg) as a solution and associated with magnetic albumin microspheres. The magnetic dosage form was targeted to a predefined tail segment with a magnetic field strength of 8000 G applied for 30 min after dosing. A physiological pharmacokinetic model was used to describe the disposition of adriamycin following its administration from either dosage form. The model developed for the data resulting from administration of adriamycin as a solution served as a foundation for the model developed for adriamycin resulting from the administration of adriamycin associated with the magnetic dosage form. The model for adriamycin following administration of the magnetic microspheres required additional relationships to describe the transport of adriamycin associated with the microspheres. For both models, the predicted adriamycin concentrations were in adequate agreement with the observed values. The present investigation demonstrates the use of a physiological pharmacokinetic modeling method to represent drug kinetics following its administration via a targeted drug delivery system.
Gallo
J M
JM
Department of Pharmaceutics, College of Pharmacy, University of Georgia, Athens 30602.
Hung
C T
CT
Gupta
P K
PK
Perrier
D G
DG
D000418:Albumins; D000818:Animals; D004317:Doxorubicin / Q000493:pharmacokinetics*; D005260:Female; D008280:Magnetics; D008863:Microspheres; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains
D000418:Albumins; D004317:Doxorubicin