title: Fatal cutaneous T cell lymphoma in a child with atopic dermatitis.
abstract: The development of a fatal cutaneous T cell lymphoma in a child with atopic disease is presented. From very early childhood the patient had classic atopic dermatitis, and at age 13 developed lymphoma-like skin tumors. The diagnosis--based on immunohistologic criteria--was initially difficult to establish, but cytogenetic and DNA studies of the dermal infiltrate supported the clinical suspicion of malignancy. In addition, the T cell receptor beta chain gene showed a clonal rearrangement pattern both in skin and in lymph node, suggesting malignancy. Whether the malignant evolution in our patient took place primarily in the skin or in the lymph nodes is difficult to decide. Further examination of the association between atopic dermatitis and cutaneous T cell lymphoma may lead to insights into both disorders.
authors: Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
authors: G
authors: G
authors: Lange-Vejlsgaard
authors: E
authors: E
authors: Ralfkiaer
authors: J K
authors: JK
authors: Larsen
authors: N
authors: N
authors: O'Connor
authors: K
authors: K
authors: Thomsen
mesh_terms: D000293:Adolescent; D004273:DNA, Neoplasm / Q000032:analysis; D003876:Dermatitis, Atopic / Q000150:complications*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000150:complications* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes
chemical_list: D004273:DNA, Neoplasm