[The effect of vestibuloprotectors on the cyclic nucleotide system in experimental motion sickness].
Changes in the blood plasma cyclic nucleotide (cAMP and cGMP) level under the effect of vestibuloprotectors: bemytil and etoxibemytil were studied in rats with experimental motion sickness. It is established that rotation causes increase in the cAMP level and decrease in the cGMP level. The effect of the vestibuloprotectors is determined by the dose of the drug and is aimed first of all at maintaining a stable cAMP level in vestibular exertion. Under conditions of this experiment etoxibemytil was more effective than bemytil.
Leshchiniuk
I I
II
Konovalova
E O
EO
Kvitchataia
A I
AI
Shamraĭ
V G
VG
Bobkov
Iu G
IuG
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D008297:Male; D009041:Motion Sickness / Q000378:metabolism*; D009712:Nucleotides, Cyclic / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D001562:Benzimidazoles; D009712:Nucleotides, Cyclic; C049825:bemethyl
Vliianie vestibuloprotektorov na sistemu tsiklicheskikh nukleotidov pri modelirovanii bolezni dvizheniia.