Calcitonin gene-related peptide is an inhibitor of aldosterone secretion.
This study examined the effects of calcitonin gene-related peptide (CGRP) on aldosterone secretion both in vivo and in vitro. Intravenous administration of CGRP (0.01 micrograms/kg) in 6 conscious dogs produced a significant decrease in plasma aldosterone concentration from 68 +/- 12 pg/ml to 28 +/- 11 pg/ml (p less than 0.05) despite a mild but significant elevation of plasma renin activity. In an in vitro study using isolated rabbit adrenal glomerulosa cells CGRP reduced the basal aldosterone secretion in a dose-related manner and furthermore 10(-9) M CGRP inhibited the aldosterone secretion stimulated by 10(-8) M angiotensin II. From these results it is suggested that CGRP has an inhibitory effect on aldosterone secretion.
Murakami
M
M
Department of Internal Medicine, Keio University, School of Medicine, Tokyo, Japan.
Suzuki
H
H
Nakajima
S
S
Nakamoto
H
H
Kageyama
Y
Y
Saruta
T
T
D000450:Aldosterone / Q000097:blood / Q000378:metabolism; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D002478:Cells, Cultured; D004285:Dogs; D005260:Female; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology*; D009994:Osmolar Concentration; D011817:Rabbits; D015384:Zona Glomerulosa / Q000166:cytology / Q000378:metabolism
D000451:Mineralocorticoid Receptor Antagonists; D000450:Aldosterone; D015740:Calcitonin Gene-Related Peptide