Changes of neutrophil elastase and alpha 1-antitrypsin in systemic lupus erythematosus.
Contents of HNE and alpha 1-AT and the positive rates of PMN-Ab in patients with SLE were measured and tested by ELISA, immunodiffusion and protein-A rosette, respectively, and it was found that plasma HNE content was significantly higher in patients with SLE (61.0 +/- 13.9 ng/ml) than in normal controls (33.7 +/- 6.7 ng/ml, P less than 0.001), while plasma alpha 1-AT in patients with SLE (2.79 +/- 0.47 mg/ml) was similar to that in normal controls (2.55 +/- 0.38 mg/ml, P greater than 0.6). The positive rate of PMN-Ab in SLE (9.8 +/- 6.5) was also significantly higher than that in normal (0.17 +/- 0.2%, P less than 0.001). The results suggest that there is an imbalance between plasma HNE and alpha 1-AT in SLE regardless of WBC or the positive rate of PMN-Ab, with this imbalance probably being due to activation of neutrophils following multiorgan damage of SLE.
Zhang
X H
XH
Yan
Y H
YH
Liang
Z Q
ZQ
Cui
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Jiang
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M
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000096:biosynthesis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology* / Q000276:immunology; D010196:Pancreatic Elastase / Q000097:blood*; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
D001323:Autoantibodies; D000515:alpha 1-Antitrypsin; D010196:Pancreatic Elastase