title: [Microinvasive stage Ia cancer of the uterine cervix--results of a multicenter clinic based analysis].
abstract: A retrospective multicentre study to investigate diagnosis, treatment and end results of treatment of cervical cancer stage Ia, was carried out in 6 departments of gynaecological oncology. After reclassification by a reference pathologist, among the 936 cervical cancer cases primarily diagnosed and treated as stage Ia between 1970 and 1980, only 530 (56.6%) met the criteria of microinvasive cancer stage Ia. Misclassifications concerned all participating centres with statistically significant differences amongst them. Overdiagnosis (reference diagnosis only CIN I-III, 42.5%) was more frequent than underdiagnosis (reference diagnosis stage Ib--0.9%). In comparison to 1970-74, in the period 1975-80 a significant increase of cases detected asymptomatically (86.5%) was observed. The percentage of cases primarily diagnosed by cone biopsy, also increased significantly and amounted to 71.2%. Patients with cervical cancer stage Ia were most frequently treated by surgery alone (93.2%). Radiotherapy alone did not play any important role (5.7%). There were only a few cases treated by combined surgery and radiotherapy (5.7%) with a decreasing trend over time. Women under the age of 45 years were significantly more frequently treated by the conservative method (cone biopsy, simple hysterectomy) than older ones, without any significant relation between depth of invasion and radicality of treatment. A total of 19 (14 local, 5 lymph node) recurrences were diagnosed between 9 and 110 months after primary treatment. Local recurrences could be observed more frequently after limited than extended treatment. There was no significant relation between depth of invasion and frequency of recurrences, but the latter were significantly increased in cases with histologically proven invasion of blood or lymph vessels.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Klinik und Poliklinik für Onkologie-Bereich Medizin (Charité) der Humboldt-Universität zu Berlin.
authors: K
authors: K
authors: Ebeling
authors: K
authors: K
authors: Bilek
authors: D
authors: D
authors: Johannsmeyer
authors: E
authors: E
authors: Rohde
authors: F
authors: F
authors: Wagner
authors: J
authors: J
authors: Buchmann
authors: M
authors: M
authors: Heiner
authors: B
authors: B
authors: Johannsmeyer
authors: L
authors: L
authors: Glodde
authors: K D
authors: KD
authors: Rüdiger
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D002584:Cervix Uteri / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery
vernacular_title: Mikroinvasives Karzinom der Cervix uteri Stadium Ia--Ergebnisse einer multizentrischen Klinikbezogenen Analyse.