Brain glutathione and the anti-hypoxic effect of glutathione depletors in mice.
The anti-hypoxic effect (assessed by a standard hypoxia survival test) 3 hr after 2-cyclohexene-1-one (CHX) was completely abolished by injections of L-cysteine after CHX. Under these conditions, brain GSH was depleted to about 50% of the control level in CHX-treated mice and recovered to about 80% of control level following L-cysteine post-treatment. However, D-cysteine could not cause such effects. Intracerebroventricular injection of CHX, which caused a selective depletion of brain GSH, produced an anti-hypoxic effect. Thus, the anti-hypoxic effect may be related to the decrease of brain GSH levels.
Masukawa
T
T
Department of Biology and Clinical Physiology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Sai
M
M
Tochino
Y
Y
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003510:Cyclohexanes / Q000494:pharmacology*; D003512:Cyclohexanones / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D003545:Cysteine / Q000494:pharmacology; D005978:Glutathione / Q000172:deficiency*; D000860:Hypoxia / Q000188:drug therapy*; D007276:Injections, Intraventricular; D007659:Ketones / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013237:Stereoisomerism
D003510:Cyclohexanes; D003512:Cyclohexanones; D007659:Ketones; C036468:cyclohexanone; C018637:phorone; D005978:Glutathione; D003545:Cysteine