title: Allergy and asthma: distinguishing the causes from the triggers. An eye model for the study of inflammatory events following allergen challenge.
abstract: The study of the late-phase reaction to allergen challenge has greatly contributed to increasing understanding of the relationship existing between immunoglobulin E (IgE) triggering, allergic inflammation and bronchial hyperreactivity, as well as to changing our concept from "causes" to "triggers" of asthma. This paper reviews personal studies on a model of conjunctival provocation in allergic subjects. These studies represent the first evidence of a late-phase reaction in the human eye and contribute to a better knowledge of the network of cells and mediators involved in allergic inflammation which are responsible for heightened bronchial reactivity in allergic asthma.
authors: Andrea Cesalpino Foundation, Institute of Clinica Medica, University La Sapienza, Rome, Italy.
authors: S
authors: S
authors: Bonini
authors: E
authors: E
authors: Adriani
authors: S
authors: S
authors: Bonini
authors: G
authors: G
authors: De Petrillo
authors: G G
authors: GG
authors: Loggi
authors: A
authors: A
authors: Adabbo
authors: M
authors: M
authors: Pani
authors: F
authors: F
authors: Balsano
mesh_terms: D001249:Asthma / Q000209:etiology / Q000276:immunology*; D003233:Conjunctivitis, Allergic / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D006801:Humans; D006109:Poaceae