Insulin-like growth factor-1 (IGF-1) in mice reduces weight loss during starvation.
Plasma concentrations of IGF-1 decrease markedly during starvation secondary to a reduction in somatotropic receptors in the liver. We investigated whether IGF-1 administration during starvation in mice inhibits the catabolic state normally observed. Plasma concentrations of IGF-1 in starved mice receiving IGF-1 therapy were similar to values from non-starved mice, whereas bGH treatment failed to increase plasma IGF-1 levels. The degree of weight loss during 36 hours of starvation was reduced (p less than 0.01) by frequent treatment with subcutaneous IGF-1 but not by bGH therapy. The effect was restricted to the period 28 to 36 hours after commencement of the fast. These results suggest that a fall in circulating IGF-1 may play a role in the metabolic adaptation during malnutrition.
O'Sullivan
U
U
Department of Paediatrics, University of Auckland, New Zealand.
Gluckman
P D
PD
Breier
B H
BH
Woodall
S
S
Siddiqui
R A
RA
McCutcheon
S N
SN
D000818:Animals; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013002:Somatomedins / Q000494:pharmacology*; D013217:Starvation / Q000503:physiopathology*; D015431:Weight Loss / Q000187:drug effects*
D013002:Somatomedins; D007334:Insulin-Like Growth Factor I