[Isoniazid therapy in severe cerebellar, postural and kinetic tremor].
In the routine analysis of patients with tremors, we have the routine analysis of patients with tremors, we have encountered three patients with severe cerebellar postural & kinetic tremors. Surface EMG study revealed alternating activity in antagonistic muscles with low frequency (3-5 cps) and wide duration (over 125msecs). They were different to typical essential tremor & parkinson's tremor in the clinical manifestation and tremogram. The tremor did not respond to high dose of propranolol (120-160mg/day), but responded to high dose of isoniazid (800-1200mg/day). Patients were evaluated before & after INH therapy with videotaping, surface EMG quantitative recording. One patient had transient side effects (abnormal liver function) in the beginning of treatment possibly because he was a "slow acetylator". The possible mechanism of effort of INH was discussed.
Shu
Y D
YD
Chang
M K
MK
Hsein
H H
HH
D000328:Adult; D000368:Aged; D002526:Cerebellar Diseases / Q000188:drug therapy*; D004576:Electromyography; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011187:Posture; D014202:Tremor / Q000188:drug therapy*
D007538:Isoniazid