title: Mousepox in inbred mice innately resistant or susceptible to lethal infection with ectromelia virus. V. Genetics of resistance to the Moscow strain.
abstract: The genetics of resistance to the Moscow strain of ectromelia virus was examined in crosses derived from resistant C57BL/6 (B6) and susceptible DBA/2 (D2) mice. Infection with 10(1) to 10(5) PFU of virus resulted in mortalities of 90 to 100% of D2, 0% of B6 and 0 to 3% of (B6 x D2) F1 mice by day 21. Among F1 x D2 backcross progeny, 49% of male and 18% of female mice died. Reciprocal backcrossing did not alter male or female mortality rates. These data are consistent with a single autosomal dominant gene controlling resistance to ectromelia in male mice and at least one additional dominant sex-limited gene controlling resistance in female mice. Fewer male F2 mice died than were predicted based on single-locus control and 32% of recombinant inbred (RI) strains derived from B6 and D2 progenitors expressed non-parental phenotypes. Therefore, additional resistance genes, not expressed in backcross mice, were apparently expressed in F2 mice and RI strains.
authors: Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut.
authors: D
authors: D
authors: Brownstein
authors: P N
authors: PN
authors: Bhatt
authors: R O
authors: RO
authors: Jacoby
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D004481:Ectromelia virus / Q000472:pathogenicity; D004482:Ectromelia, Infectious / Q000276:immunology* / Q000401:mortality; D005260:Female; D007113:Immunity, Innate / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics* / Q000382:microbiology; D008811:Mice, Inbred DBA / Q000235:genetics* / Q000382:microbiology; D012737:Sex Factors; D014774:Virulence