[Interleukin 2 secretion by lymphocytes of patients with squamous cell cancer of the oropharynx or larynx].
The various strengthening influences of interleukin-2 (IL-2) on the immunological system is of intrinsic importance to tumour defense. IL-2 concentration can be measured by the determination of the IL-2 dependent CTLL cell line in a micro-Elisa-assay. The IL-2 secretion is dose dependent after stimulation with the mitogens phytohaemagglutinin A (PHA), phorbolester (PMA) or the monoclonal T cell antibody OKT3. Maximal IL-2 release is achieved by concomitant activation with phytohaemagglutinin A (PHA) and phorbolester (PMA). As controls healthy donors with low and high alcohol and cigarette consumption were used. In patients with cancer of the oropharynx, a significant reduction in the IL-2 secretion was observed when compared with the larynx cancer group or with healthy donors. This might suppose an immunological influence of the squamous cell carcinoma which grows in the oropharynx in close proximity to lymphatic cells and vessels which are numerously present in the tonsillar ring of Waldeyer.
Wustrow
T P
TP
Klinik und Poliklinik für Hals-, Nasen- und Ohrenkranke, Ludwig-Maximilians-Universität.
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000096:biosynthesis*; D007822:Laryngeal Neoplasms / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000276:immunology*; D010610:Pharyngeal Neoplasms / Q000276:immunology*; D012907:Smoking / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014407:Tumor Cells, Cultured / Q000276:immunology
D007376:Interleukin-2
Interleukin-2 Sekretion aus Lymphozyten von Patienten mit Plattenepithelkarzinomen im Oropharynx oder Larynx.