Pharmacokinetics of ranitidine in critically ill infants.
The pharmacokinetic parameters of ranitidine were studied following administration of a single intravenous dose in 9 critically ill infants. Ranitidine disposition was best described by a biphasic elimination curve. For 8 patients, the mean values for T1/2, apparent volume of distribution, and total body clearance were 2.09 h, 1.61 l/kg, and 13.93 ml/min/kg, respectively. Based on simulated steady-state concentration profiles, a dose of 0.7 mg/kg administered intravenously every 6 h should maintain serum levels above 40 ng/ml for 4.7 h of the dosing interval with a wide degree of variability.
Wiest
D B
DB
Department of Hospital Pharmacy Practice, Medical University of South Carolina, Charleston.
O'Neal
W
W
Reigart
J R
JR
Brundage
R C
RC
Gillette
P C
PC
Yost
R L
RL
D002675:Child, Preschool; D002701:Chloramphenicol / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D005750:Gastric Juice / Q000032:analysis; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000378:metabolism; D006418:Heme / Q000032:analysis; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D010437:Peptic Ulcer / Q000517:prevention & control; D011899:Ranitidine / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology
D006418:Heme; D002701:Chloramphenicol; D011899:Ranitidine