[Studies on synthesis of baogongteng A--a new myotic agent].
Baogongteng A, isolated from Erycibe obtusifolia Benth., is a new tropane alkaloid used for treating glaucoma. Using synthetic 6 beta-acetoxy-tropinone as starting material, racemic Baogongteng A(8) was synthesized. Synthetic Baogongteng A also shows myotic activities in rabbits, but the potency is half of that of the natural product.
Xiang
Z
Z
Zhou
J E
JE
Chen
Z N
ZN
Wang
L P
LP
Wang
H N
HN
Yao
T R
TR
Xie
J X
JX
Xu
G Y
GY
Yi
D N
DN
D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D008916:Miotics / Q000138:chemical synthesis*; D014326:Tropanes
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; D008916:Miotics; D014326:Tropanes; C027863:bao gong teng A