title: [Increased urinary excretion of neopterin in patients with Graves-Basedow disease].
abstract: In 12 patients with Graves'-Basedows' disease treated with carbimazole, the mean urinary neopterin, excretion (indicator of stimulation of cellular immunity) was 757.17 +/- 184.17 (95% confidence limit) mumol/mol creatinine with a range of 367-1420. In 12 healthy subjects of matching age and sex who served as controls the mean excretion was 422.0 +/- 96.38 (range 115 to 711, p less than 0.01). It cannot be ruled out that this increase is due to the immunomodulating action of carbimazole.
authors: V
authors: V
authors: Schreiber
authors: Z
authors: Z
authors: Tomsová
authors: Z
authors: Z
authors: Límanová
authors: Z
authors: Z
authors: Jůzová
mesh_terms: D001708:Biopterins / Q000031:analogs & derivatives* / Q000652:urine; D002231:Carbimazole / Q000627:therapeutic use; D006111:Graves Disease / Q000188:drug therapy / Q000652:urine*; D006801:Humans; D008875:Middle Aged; D019798:Neopterin
chemical_list: D001708:Biopterins; D019798:Neopterin; D002231:Carbimazole
vernacular_title: Zvýsená exkrece neopterinu mocí u nemocných s Graves-Basedowovou nemocí.