[Effect of foridon on the blood supply of the cat brain in health and in intracerebral hemorrhage].
In experiments on anesthetized cats, foridone (1 and 3 micrograms/kg/min intravenously) was found to increase cerebral blood flow by 6-26% with a moderate decrease of systemic arterial blood pressure indicating that the drug possessed properties with respect to a selective cerebral vasodilatator. Phenygidine (0.3-3 micrograms/kg/min) did not exhibit such a property. Intravenous administration of foridone (1 microgram/kg/min) to cats one day after intracerebral hemorrhage produced a significant improvement of blood supply to the brain, glucose utilization by the brain, a moderate increase of oxygen consumption.
Chernysheva
G A
GA
Plotnikov
M B
MB
Kastron
V V
VV
Vitolinia
R O
RO
Dubur
G Ia
GIa
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D050260:Carbohydrate Metabolism; D002415:Cats; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects; D007262:Infusions, Intravenous; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D010101:Oxygen Consumption / Q000187:drug effects
D000959:Antihypertensive Agents; D009543:Nifedipine; D005947:Glucose; C045912:ryodipine
Vliianie foridona na krovosnabzhenie mozga koshek v norme i pri vnutrimozgovom krovoizliianii.