Increased proto-oncogene expression in peripheral blood T lymphocytes from patients with systemic sclerosis.
The expression of c-myc, c-myb, and c-ras proto-oncogenes, determined using RNA hybridization techniques (slot-blot), was significantly increased in peripheral blood T lymphocytes, but not in B cells, from 17 patients with systemic sclerosis with diffuse scleroderma, compared with the expression in normal control subjects. The magnitude of expression of c-myc and c-myb tended to be higher in patients with early, active disease. These results demonstrate an in vivo activation of T cells from systemic sclerosis patients, which may play an important role in the pathogenesis of the disease.
Kahan
A
A
INSERM U-283, Hôpital Cochin, Paris, France.
Gerfaux
J
J
Kahan
A
A
Joret
A M
AM
Menkès
C J
CJ
Amor
B
B
D000199:Actins / Q000032:analysis; D000328:Adult; D001402:B-Lymphocytes; D015152:Blotting, Northern; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D012595:Scleroderma, Systemic / Q000097:blood* / Q000235:genetics; D013601:T-Lymphocytes
D000199:Actins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas