Perinatal bromopride treatment: effects on sexual behavior of male and female rats.
Effects of different perinatal bromopride treatments on sexual behavior were examined in adult male and female rats of Wistar origin. Female rats of mothers treated with bromopride (BRO) during lactation (VB group) and during pregnancy and lactation (BB group) showed lower lordosis quotients than those of controls (VV group). Females of mothers treated with BRO only during pregnancy (BV group) showed no differences in lordosis quotient when compared to the VV group. There were no significant differences in male sexual behavior between experimental and control groups. The effect of bromopride on the control of sexual behavior is discussed.
Felicio
L F
LF
Clinical Pharmacology and Toxicology, School of Veterinary Medicine, University of São Paulo, Brazil.
Palermo-Neto
J
J
Nasello
A G
AG
D000818:Animals; D000831:Animals, Newborn; D003307:Copulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D008297:Male; D008787:Metoclopramide / Q000031:analogs & derivatives* / Q000494:pharmacology; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012733:Sex Differentiation / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D011374:Progesterone; D004958:Estradiol; C013855:bromopride; D008787:Metoclopramide