[Prospects of vaccination against schistosomiasis].
Schistosomiasis, the second parasitic infection in the world, might well be the first for which a vaccine could be proposed. Investigations on the mechanisms of protective immunity have allowed the characterization of target antigens, but also revealed that susceptibility to reinfection depends on the production of blocking antibodies. A genetic engineering-produced schistosome protein (P28) is presently the most potent antigen for the induction of a protective immune response in all the experimental models, including non-human primates.
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D006801:Humans; D012552:Schistosomiasis / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination
Perspectives vaccinales contre la bilharziose.