Concanavalin A reveals olfactory receptors which discriminate between alkane odorants on the basis of size.
For certain odorants, the amplitude of the rat electro-olfactogram is reduced if the olfactory epithelium is treated with the lectin concanavalin A. When normal and cycloalkanes of one to ten carbon atoms are used as odorants at equimolar concentration, the maximum reduction in amplitude is found to correlate with the size of the stimulus molecule. This observation is consistent with the notion that concanavalin A disables an olfactory receptor molecule which normally responds to the alkyl moiety of odorants in a particular size range. That moiety may thus represent a 'primary' quality-determining component in odour discrimination.
Polak
E H
EH
Department of Chemistry, University of Warwick, Coventry, U.K.
Shirley
S G
SG
Dodd
G H
GH
D000473:Alkanes; D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology*; D003516:Cycloparaffins; D008297:Male; D015394:Molecular Structure; D009812:Odorants; D009831:Olfactory Mucosa / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011984:Sensory Receptor Cells / Q000187:drug effects* / Q000502:physiology
D000473:Alkanes; D003516:Cycloparaffins; D003208:Concanavalin A