Identification and characterization of a cell-surface molecule that is selectively induced on rat lymphokine-activated killer cells.
We have identified a 40- to 45-kDa cell-surface molecule designated gp42, that is expressed in high levels by rat lymphokine-activated killer (LAK) cells of NK cell origin. gp42 cannot be detected on the precursors of LAK cells and is not present on resting or activated T cells. Rather, expression of gp42 is selectively induced on NK cells by the high concentrations of rIL-2 that are required for the induction of LAK activity. Although the function of gp42 is not known, the selective nature of its expression suggests a role for this molecule in regulating responses that are unique to IL-2-activated NK cells.
Imboden
J B
JB
Department of Medicine, University of California, San Francisco.
Eriksson
E C
EC
McCutcheon
M
M
Reynolds
C W
CW
Seaman
W E
WE
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology*; D015153:Blotting, Western; D002460:Cell Line; D005434:Flow Cytometry; D006023:Glycoproteins / Q000276:immunology* / Q000378:metabolism; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D008970:Molecular Weight; D051381:Rats
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D006023:Glycoproteins