Polymorphonuclear leukocyte chemiluminescence response in HLA-B27 positive and negative arthritic patients.
The polymorphonuclear leukocyte (PMN) chemiluminescence (CL) response to opsonized zymosan reflecting the C3b/C3bi-receptor-mediated PMN respiratory burst activation was studied in 99 arthritic patients typed for the HLA-B27 antigen. The results indicate that the B27 antigen per se is not associated with disturbances in PMN CL response. However, the erythrocyte sedimentation rate showed a correlation with CL, suggesting that the activity of arthritic disease may affect the PMN CL response.
Tertti
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Department of Medical Microbiology, University of Turku, Finland.
D001168:Arthritis / Q000097:blood*; D001799:Blood Sedimentation; D015235:HLA-B Antigens / Q000032:analysis*; D015796:HLA-B27 Antigen; D006801:Humans; D008163:Luminescent Measurements; D009504:Neutrophils / Q000032:analysis* / Q000187:drug effects; D009895:Opsonin Proteins / Q000494:pharmacology; D015054:Zymosan / Q000494:pharmacology
D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D009895:Opsonin Proteins; D015054:Zymosan