Cyanoacrylates and corneal abrasion.
Cyanoacrylate-containing adhesives such as Super Glue, Krazy Glue, and a vast array of artificial nail adhesives are monomers which rapidly polymerize and bond in the presence of water or weak bases. Inadvertent contact with skin or tissue can also cause rapid bonding with resultant irritation. To assess the magnitude of problems associated with ocular contamination involving cyanoacrylates, a 12-month prospective study was conducted. 34 cases (21 adult and 13 pediatric) were collected. In all cases, contaminated eyes were thoroughly irrigated with tepid water for 15 minutes. 15 patients (44%) suffered a corneal abrasion, as determined by ophthalmic exam, necessitating treatment with antibiotics, cycloplegics, and patching. Individuals reporting complete resolution were irrigated with 20 minutes of exposure, while patients suffering mechanical injury delayed decontamination for a minimum of 15 minutes. In addition to immediate irrigation of eyes exposed to cyanoacrylates, we recommend an ophthalmologic evaluation to rule out the possibility of mechanical injury.
Dean
B S
BS
Pittsburgh Poison Center, Children's Hospital of Pittsburgh, PA 15213.
Krenzelok
E P
EP
D000269:Adhesives / Q000633:toxicity*; D000293:Adolescent; D000328:Adult; D002648:Child; D003315:Cornea / Q000187:drug effects*; D003316:Corneal Diseases / Q000139:chemically induced / Q000628:therapy*; D003487:Cyanoacrylates / Q000633:toxicity*; D006801:Humans; D008899:Mineral Oil / Q000627:therapeutic use; D011446:Prospective Studies; D007507:Therapeutic Irrigation; D000267:Tissue Adhesions / Q000139:chemically induced / Q000628:therapy; D014867:Water
D000269:Adhesives; D003487:Cyanoacrylates; D014867:Water; D008899:Mineral Oil