99mTc ethoxy methylpropyl isonitrile: a radioactive tracer for myocardial perfusion imaging.
The initial experience with a new 99mTc labelled myocardial perfusion agent, ethoxy methylpropyl isonitrile (EMI), is described in the primate as model. Rapid biliary clearance of EMI ensures low radionuclide concentration in the liver and lungs after 60 min. Adequate visualization of the myocardium is therefore possible. Heart-to-lung and heart-to-liver ratios of 1.52 and 2.45 respectively were obtained. EMI is an efficient imaging agent to evaluate myocardial ischemia and infarction.
van Aswegen
A
A
Medical Faculty, University of the Orange Free State, Bloemfontein, South Africa.
van Wyk
A J
AJ
Herbst
C P
CP
Otto
A C
AC
Viviers
A
A
Koekemoer
J
J
Knoesen
O
O
Lötter
M G
MG
Minnaar
P C
PC
Kleynhans
P H
PH
D000818:Animals; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D009570:Nitriles / Q000138:chemical synthesis / Q000493:pharmacokinetics; D015609:Organotechnetium Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics; D010215:Papio; D014055:Tomography, Emission-Computed
D009570:Nitriles; D015609:Organotechnetium Compounds; C061703:technetium Tc 99m 2-ethoxy-2-methylpropylisonitrile