[Occlusive arterial disease after radiation].
A 50-year-old man was treated for occlusion of the superficial femoral artery which had developed 6 years after X-ray therapy to the thigh for a malignant tumor. Occlusive arterial disease is more common after doses of more than 4000 rad and appears more frequently within the first 10 years after doses of 5000 rad or more. Clinical and experimental data suggest that X-radiation predisposes to atherosclerotic change by causing endothelial damage. The clinical approach to symptomatic occlusive disease of arteries that traverse irradiated fields is similar to treatment of other atherosclerotic lesions, except that in some instances an extra-anatomic route should be considered if bypass is required.
Shinfeld
A
A
Adar
R
R
D001157:Arterial Occlusive Diseases / Q000209:etiology* / Q000628:therapy; D004307:Dose-Response Relationship, Radiation; D005263:Femoral Artery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology* / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects*; D013848:Thigh / Q000528:radiation effects*; D013997:Time Factors