[The functional role of the oxytocin-sensitive hippocampal system in organizing the mechanisms of morphine addiction].
The effect of oxytocin (OXT) administration into the brain ventricles on the process of narcotic dependence formation was studied before and following hippocampal lesion. OXT was found to inhibit the process of narcotic dependence formation. The hippocampal lesion weakened the inhibitory effect. A specific hippocampal involvement in the processes of narcotic reinforcement was suggested.
Ibragimov
R Sh
RSh
D000818:Animals; D004564:Electrocoagulation; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007276:Injections, Intraventricular; D008845:Microinjections; D009020:Morphine / Q000008:administration & dosage; D009021:Morphine Dependence / Q000209:etiology* / Q000503:physiopathology; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012646:Self Administration; D012653:Self Stimulation / Q000187:drug effects / Q000502:physiology
D010121:Oxytocin; D009020:Morphine
Funktsional'naia rol' oksitotsinchuvstvitel'noĭ sistemy gippokampa v organizatsii mekhanizmov vlecheniia k morfinu.