Thymus fraction (FIII) effect on cholesterol metabolism: modulation of the low density lipoprotein receptor pathway.
1. A heat stable protein fraction from calf thymus is able to determine a marked drop of total serum cholesterol and B apoproteins in rats fed a cholesterol enriched diet. 2. It is known that the catabolism of low density lipoprotein (LDL) cholesterol is mediated by the existence of high affinity surface receptor on membrane cells. 3. The purpose of the present paper is to verify if the heat stable thymus protein fraction is able to affect the LDL receptor pathway in vitro. 4. The results obtained show that the protein calf thymus is able to increase human and rat LDL catabolism.
Mondola
P
P
Istituto di Scienze Fisiologiche Umane, Università di Napoli, Italia.
Santillo
M
M
Tedesco
I
I
Santangelo
F
F
Belfiore
A
A
Bifulco
M
M
D000328:Adult; D000818:Animals; D001667:Binding, Competitive; D002417:Cattle; D002460:Cell Line; D002784:Cholesterol / Q000097:blood*; D006801:Humans; D008099:Liver; D051381:Rats; D011915:Rats, Inbred BUF; D011973:Receptors, LDL / Q000187:drug effects* / Q000502:physiology; D013951:Thymus Hormones
D011973:Receptors, LDL; D013951:Thymus Hormones; C017757:thymarin; D002784:Cholesterol