Behavioral teratogenic insult of methylmercury assessed by using sets of measures: reanalysis of data from the Collaborative Behavioral Teratology Study of National Center for Toxicological Research.
The data of the Collaborative Behavioral Teratology Study were analyzed by using sets of measures simultaneously. A set of preweaning measures offered far more information as to treatment effects than a set of postweaning measures. The treatment effect observed in behavioral measures was also explained considerably by physical measures. However, the effect explained by uniquely behavioral measures (i.e., magnitude of semipartial R2) was also observed in some degree. A sex-related difference was observed in auditory startle response habituation appearing only later or earlier in life. The usefulness of using a set of measures and assessing the relationship among sets in behavioral teratology, in addition to conventional single measure analysis, was discussed.
Tachibana
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Institute for Developmental Research, Aichi Prefectural Colony, Japan.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003627:Data Interpretation, Statistical; D005260:Female; D008297:Male; D008722:Methods; D008767:Methylmercury Compounds / Q000494:pharmacology*; D012737:Sex Factors
D008767:Methylmercury Compounds