[Effect of immunocorrective agents on the production of the human immunodeficiency virus type 1 in vitro].
Enhancement of HIV-I production by immunostimulators leakadine (5 micrograms/ml) and thymosin (10 micrograms/ml) by 40 +/- 10% and a significant inhibition of HIV-I production by immunosuppressors cortisone and dexasone was demonstrated in H9 culture. HIV-I production was estimated by the number of cells expressing viral antigens on the membranes. The effect of modulation by immunocorrective agents of H9 cell sensitivity to HIV-I was found not to be associated with the effect of the drugs on CD4-receptor expression. A relationship between the immunostimulating doses of the drug and the concentration in which it enhances virus production was demonstrated. Possible mechanisms of the phenomenon are discussed.
Nesterchuk
S L
SL
Barinskiĭ
I F
IF
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015488:HIV Antigens / Q000032:analysis; D015497:HIV-1 / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008934:Mitogens / Q000494:pharmacology; D014776:Virus Cultivation / Q000379:methods; D014779:Virus Replication / Q000187:drug effects
D000276:Adjuvants, Immunologic; D000945:Antigens, Differentiation, T-Lymphocyte; D015488:HIV Antigens; D007166:Immunosuppressive Agents; D008934:Mitogens
Vliianie immunokorrektorov na produktsiia virusa immunodefitsita cheloveka I tipa in vitro.