title: A possible autocrine role for interleukin-6 in two lymphoma cell lines.
abstract: Interleukin-6 (IL-6) is a growth factor with diverse biologic activity. Originally described as a T-cell product that enhances immunoglobulin (Ig) secretion in antigen-stimulated B cells, it also affects the growth of T cells, plasmacytomas, hybridomas, and hematopoietic stem cells. We report the expression and secretion of IL-6 by two lymphoma cell lines, OCI-LY3 and OCI-LY12. Addition of recombinant IL-6 stimulated their growth, whereas addition of polyclonal anti-recombinant IL-6 (anti-rIL-6) had a marked inhibitory effect on proliferation. These results suggest an autocrine role for IL-6 in the growth of these lymphoma cells in culture.
authors: Department of Medicine and Medical Biophysics, Ontario Cancer Institute, Toronto, Canada.
authors: C
authors: C
authors: Yee
authors: A
authors: A
authors: Biondi
authors: X H
authors: XH
authors: Wang
authors: N N
authors: NN
authors: Iscove
authors: J
authors: J
authors: de Sousa
authors: L A
authors: LA
authors: Aarden
authors: G G
authors: GG
authors: Wong
authors: S C
authors: SC
authors: Clark
authors: H A
authors: HA
authors: Messner
authors: M D
authors: MD
authors: Minden
mesh_terms: D015152:Blotting, Northern; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004273:DNA, Neoplasm / Q000302:isolation & purification; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D015850:Interleukin-6; D007378:Interleukins / Q000096:biosynthesis / Q000276:immunology / Q000502:physiology*; D008223:Lymphoma / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000302:isolation & purification; D012260:Ribonucleases; D014407:Tumor Cells, Cultured / Q000378:metabolism*
chemical_list: D004273:DNA, Neoplasm; D006133:Growth Substances; D007106:Immune Sera; D015850:Interleukin-6; D007378:Interleukins; D012333:RNA, Messenger; D012260:Ribonucleases