title: The effect of electrocortical state on cerebral carbohydrate metabolism in fetal sheep.
abstract: We measured hemispherical cerebral blood flow and arteriovenous differences across the cerebral cortex for glucose, oxygen, and lactate during the two primary electroencephalographic patterns (high and low voltage) in unanesthetized, near-term fetal sheep. Oxygen consumption was 127 mumol/min/100 g brain in high voltage and was 14% higher in low voltage. Glucose uptake was 19 mumol/min/100 g and was 37% higher in low voltage. Cerebral blood flow was 112 ml/min/100 g and was 29% higher in low voltage. The glucose:oxygen quotient increased from 0.91 in high voltage to 1.08 in low voltage. There was a net lactate efflux of 3.2 mumol/min/100 g during low voltage compared to a net influx of 3.3 mumol/min/100 g in high voltage. During high voltage the fetal brain uses a small amount of lactate for oxidative metabolism. During low voltage, glucose uptake exceeds the oxygen uptake needed for completely aerobic consumption, and a portion of the energy utilized by the brain is produced anaerobically.
authors: Department of Obstetrics and Gynecology, Columbia University, New York, NY 10032.
authors: C R
authors: CR
authors: Chao
authors: A R
authors: AR
authors: Hohimer
authors: J M
authors: JM
authors: Bissonnette
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D004734:Energy Metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism*; D019344:Lactic Acid; D010101:Oxygen Consumption; D012756:Sheep / Q000196:embryology / Q000378:metabolism*
chemical_list: D007773:Lactates; D019344:Lactic Acid; D005947:Glucose