Diketene analogs as beta-lactamase inhibitor.
Compounds having a structural analogy with diketene have been synthesized and their potencies as beta-lactamase inhibitors have been studied. Among six compounds so far tested, alpha-phenyl-beta-benzylidene-3-propanolide was shown to be an irreversible inhibitor of the enzyme. The availability of simple monocyclic compounds as beta-lactamase inhibitors is discussed.
Tanizawa
K
K
Santoh
K
K
Kanaoka
Y
Y
D055598:Chemical Phenomena; D002621:Chemistry; D007783:Lactones / Q000138:chemical synthesis*; D065093:beta-Lactamase Inhibitors
D007783:Lactones; D065093:beta-Lactamase Inhibitors; C004773:diketene