Amiloride reduces maternofetal clearance of sodium across the near-term rat placenta.
The effect of amiloride on unidirectional maternofetal clearance across the perfused placenta has been studied in rats at 21 days gestation. A bolus dose of 1 mg kg-1 followed by an infusion of 0.6 mg h-1 into the maternal circulation caused a significant (P less than 0.02) decrease in 22Na clearance by 8%, whilst having no effect on the clearance of 51Cr-EDTA; a ten times higher dose of amiloride (10 mg kg-1, 6 mg h-1) did not reduce 22Na clearance further. Similar administration of an equivalent volume of saline to control animals showed no effect on either Na+ or Cr-EDTA clearances.
Atkinson
D E
DE
Department of Child Health, St Mary's Hospital, University of Manchester.
Sibley
C P
CP
Robinson
N R
NR
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport; D005260:Female; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D010477:Perfusion; D010920:Placenta / Q000378:metabolism*; D011188:Potassium / Q000097:blood; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*; D012964:Sodium / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
D000584:Amiloride; D012964:Sodium; D011188:Potassium