In vivo inhibitory effect of a conjugate of immunoglobulin G and melphalan, K18, on human tumors transplanted in nude mice.
Various human tumor lines, including gastric, colonic, esophageal, pancreatic, lung and breast cancer, were transplanted in nude mice, and the effect of K18 (IgG conjugated melphalan) on them was assessed and compared with that of melphalan. Melphalan (1 mg/kg) or K18 (100 mg/kg) were administered to mice for 28 days. The tumor growth was significantly inhibited in 5 out of 6 tumors by both agents, although only the esophageal line was insensitive to both agents. Significant loss of body weight was observed in mice after treatment. K18 had no influence on body weight. These results suggested that K18 may be useful in cancer chemotherapy.
Imai
S
S
First Department of Surgery, School of Medicine, Kyoto University, Japan.
Nio
Y
Y
Shiraishi
T
T
Tsubono
M
M
Morimoto
H
H
Ohgaki
K
K
Tobe
T
T
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy; D003110:Colonic Neoplasms / Q000188:drug therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage; D000922:Immunotoxins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy; D008558:Melphalan / Q000008:administration & dosage*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D013274:Stomach Neoplasms / Q000188:drug therapy; D014407:Tumor Cells, Cultured
D007074:Immunoglobulin G; D000922:Immunotoxins; D008558:Melphalan