title: A self-splicing intron in the small subunit rRNA gene of Pneumocystis carinii.
abstract: The coding region for the Pneumocystis carinii small subunit rRNA (16S-like rRNA) contains 390 extra base pairs in a region that is highly conserved in other eukaryotic rRNA genes. The sequence has all the elements characteristic of group I self-splicing introns and interrupts the phylogenetically conserved helix proximal to the 3' terminus of the 16S-like rRNA. In vitro transcripts containing the putative group I intron were capable of undergoing a "self-splicing" reaction which required the presence of guanine nucleotide.
authors: Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
authors: M L
authors: ML
authors: Sogin
authors: J C
authors: JC
authors: Edman
mesh_terms: D000818:Animals; D001483:Base Sequence; D005796:Genes; D007438:Introns; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D011010:Pneumocystis / Q000235:genetics*; D012326:RNA Splicing; D012335:RNA, Ribosomal / Q000235:genetics*; D012336:RNA, Ribosomal, 16S / Q000235:genetics
chemical_list: D012335:RNA, Ribosomal; D012336:RNA, Ribosomal, 16S