title: Metabolic fate of L-[methyl-11C]methionine in human plasma.
abstract: The metabolites of L-[methyl-11C]methionine in the plasma of 8 patients with tumors were measured for 60 min after injection. In the plasma, after a rapid clearance, the total radioactivity remained constant, and protein-bound radioactivity increased rapidly. Non protein metabolites detected by HPLC as at least two components besides methionine, increased with time. Significant individual variations for the metabolism were observed. At 60 min after injection, 36.5% (range: 16%-72%) and 45.3% (range: 13%-74%) of the 11C was measured as methionine and labeled proteins, respectively.
authors: Division of Radiopharmaceutical Chemistry, Tohoku University, Sendai, Japan.
authors: K
authors: K
authors: Ishiwata
authors: J
authors: J
authors: Hatazawa
authors: K
authors: K
authors: Kubota
authors: M
authors: M
authors: Kameyama
authors: M
authors: M
authors: Itoh
authors: T
authors: T
authors: Matsuzawa
authors: T
authors: T
authors: Takahashi
authors: R
authors: R
authors: Iwata
authors: T
authors: T
authors: Ido
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000097:blood / Q000000981:diagnostic imaging; D002250:Carbon Radioisotopes; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000000981:diagnostic imaging; D008715:Methionine / Q000097:blood / Q000031:analogs & derivatives; D008875:Middle Aged; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D008715:Methionine; C038344:methionine methyl ester