Successful human double-lung transplantation after five and one-half hours of preservation.
Successful clinical double-lung transplantation after 5 1/2 hours of pulmonary ischemia is reported. Static hypothermic preservation with a high-volume, high flow rate-modified Collin's solution pulmonary artery flush was used. Excellent early and late pulmonary function demonstrates the efficacy of the technique that is described in detail. Lung transplantation remains limited by the lack of reliable methods of long-term storage of donor organs, but refinement of current techniques may soon allow its wider application.
Bonser
R S
RS
Minnesota Heart and Lung Institute, University of Minnesota, Minneapolis 55455.
Fischel
R
R
Fragomeni
L
L
Kaye
M
M
Burdine
J
J
Friese
C
C
Kriett
J
J
Shumway
S
S
Jamieson
S W
SW
D000328:Adult; D002315:Cardiopulmonary Bypass; D005069:Evaluation Studies as Topic; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007511:Ischemia / Q000473:pathology; D008168:Lung / Q000098:blood supply / Q000503:physiopathology; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D012129:Respiratory Function Tests; D013997:Time Factors
D007166:Immunosuppressive Agents