Lack of differentiation of the isolated murine statoacoustic ganglion during organ culture.
The isolated 12th gestational day statoacoustic ganglion (SAG) of the CBA/CBA mouse was cultured in vitro for 4-8 days. After 4 days, 25% of the SAG had survived, having nerve fibers growing in a circular pattern around the SAG. A further separation into a vestibular and a cochlear part, which occurs in vivo, was not observed. It is concluded that a trophic interaction between the SAG and target tissues is needed for further differentiation of the SAG.
Berggren
D
D
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital, Umeå, Sweden.
Anniko
M
M
D000818:Animals; D002454:Cell Differentiation; D003051:Cochlea / Q000196:embryology; D007758:Ear, Inner / Q000196:embryology*; D005724:Ganglia / Q000196:embryology*; D005865:Gestational Age; D051379:Mice; D008808:Mice, Inbred CBA; D009924:Organ Culture Techniques; D014722:Vestibule, Labyrinth / Q000196:embryology