[Immunocorrection of the physiologic status of white rats by sidnofen conjugates with bovine serum albumin].
The effect of immunisation by covalent conjugates of known psychostimulant and antidepressant sydnophen with bovine serum albumin (BSA) on behaviour, formation of conditioned reflex reactions and alcoholization of white rats has been studied. The immunization of sydnophen with BSA by conjugates permits to obtain a long-term alteration of the emotional status: suppression of behavioral activity, learning and alcohol attraction of rats similar in some elements to the action of neuroleptic drugs. The direction of these alterations is opposite to ones caused by the action of sydnophen. It gives possibility to consider fruitful the conception on the ways of long-term immunocorrection of the physiological status of organism.
Danilova
R A
RA
Obukhova
M F
MF
Sagimbaeva
Sh K
ShK
Mashkovskiĭ
M D
MD
Ashmarin
I P
IP
D000428:Alcohol Drinking / Q000187:drug effects; D000818:Animals; D000928:Antidepressive Agents / Q000276:immunology / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects; D004924:Escape Reaction / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D007114:Immunization; D000922:Immunotoxins / Q000276:immunology / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D010069:Oxadiazoles / Q000494:pharmacology*; D051381:Rats; D012710:Serum Albumin, Bovine / Q000276:immunology / Q000494:pharmacology; D013558:Sydnones / Q000276:immunology / Q000494:pharmacology*; D013997:Time Factors
D000928:Antidepressive Agents; D000922:Immunotoxins; D010069:Oxadiazoles; D013558:Sydnones; C013271:sydnophen; D012710:Serum Albumin, Bovine
Immunokorrektsiia fiziologicheskogo statusa belykh krys kon''iugatami sidnofena s bych'im syvorotochnym al'buminom.