Modulation of pulmonary artery contraction by endothelium-derived relaxing factor.
In isolated rat pulmonary artery rings, both endothelial denudation and treatment with 10(-5) M hemoglobin inhibited relaxation to acetylcholine and increased contractile sensitivities, i.e. decreased the EC50s, to KCl, angiotensin II and norepinephrine. Denudation caused similar inhibition of acetylcholine relaxation and potentiation of KCl and norepinephrine contractions in isolated bovine pulmonary arteries. These results indicate that endothelium-derived relaxing factor plays a significant role in modulating the contractile sensitivity of isolated pulmonary arteries to at least some agonists.
Yamaguchi
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T
CVP Research Laboratory, University of Colorado Health Sciences Center, Denver 80262.
Rodman
D
D
O'Brien
R
R
McMurtry
I
I
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001685:Biological Factors / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009569:Nitric Oxide; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014665:Vasodilator Agents / Q000494:pharmacology*
D001685:Biological Factors; D006454:Hemoglobins; D014665:Vasodilator Agents; D000804:Angiotensin II; D009569:Nitric Oxide; D011189:Potassium Chloride; D009638:Norepinephrine