title: Serum distribution of iodine after oral administration of ethylenediamine dihydriodide in cattle.
abstract: Serum concentrations of iodine were determined after cattle were given ethylenediamine dihydriodide (EDDI) orally at dosages ranging from 0.0 (placebo) to 0.77 mg/kg of body weight/day. The serum iodine concentration was correlated with the dosage of EDDI. A rate of 0.11 mg EDDI/kg/day was correlated with serum iodine concentrations (20 to 80 micrograms/dl) previously found to be effective in preventing foot rot in cattle. A linear dose-response curve that was generated could be helpful in predicting dosage of EDDI if the serum iodine concentration is known.
authors: California Veterinary Diagnostic Laboratory System, School of Veterinary Medicine, University of California, Davis 95616.
authors: J
authors: J
authors: Maas
authors: J N
authors: JN
authors: Berg
authors: R G
authors: RG
authors: Petersen
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002417:Cattle / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005029:Ethylenediamines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D007455:Iodine / Q000097:blood*; D008297:Male; D012044:Regression Analysis
chemical_list: D005029:Ethylenediamines; C031234:ethylenediamine; D007455:Iodine