Granzyme A expression by normal rat natural killer (NK) cells in vivo and by interleukin 2-activated NK cells in vitro.
Granzyme A (TSP-1) is a serine esterase expressed in cytotoxic T and natural killer (NK) cell lines. Its presence in in vivo primed T cells is disputed at present. Here we show that normal rat NK cells contain granzyme A in vivo and that its expression is augmented by their short-term in vitro treatment with IL 2. Granzyme A expression in a NK cell population with LAK activity has also been examined.
Velotti
F
F
Department of Experimental Medicine, University La Sapienza, Rome, Italy.
Palmieri
G
G
Morrone
S
S
Piccoli
M
M
Frati
L
L
Santoni
A
A
D000818:Animals; D002478:Cells, Cultured; D004950:Esterases / Q000032:analysis; D053804:Granzymes; D007376:Interleukin-2 / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000201:enzymology*; D008213:Lymphocyte Activation; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012697:Serine Endopeptidases / Q000032:analysis*
D007376:Interleukin-2; D004950:Esterases; C022635:serine esterase; D053804:Granzymes; D012697:Serine Endopeptidases