title: Plasma lidocaine levels following hematoma block for distal radius fractures.
abstract: Venous plasma levels of lidocaine were determined in 8 patients presenting to the emergency department with acute distal radius fractures and who had had anesthesia with fracture hematoma block. The block was performed in an aseptic fashion via a dorsal approach with a dose of 2.2-2.4 mg/kg of lidocaine without epinephrine. Onset of anesthesia was in less than 5 min which reduced pain from manipulation of the fracture to modest levels. Plasma lidocaine levels determined by gas chromatography-mass spectrometry reflected rapid systemic absorption of lidocaine from the fracture hematoma. Maximum systemic concentrations were seen at 20-30 min and ranged from 100 to 1,100 ng/ml, well below the toxic threshold of 5,000 ng/ml.
authors: Department of Orthopaedics, University of Colorado Health Sciences Center, Denver.
authors: R P
authors: RP
authors: Meinig
authors: A
authors: A
authors: Quick
authors: L
authors: L
authors: Lobmeyer
mesh_terms: D000328:Adult; D000368:Aged; D000772:Anesthesia, Local / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008349:Manipulation, Orthopedic; D008875:Middle Aged; D011885:Radius Fractures / Q000628:therapy*
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine