[Preparation and pharmacologic activity of N-oxides of 4'-(benzotriazol-2-yl-phenylalkanoic and -phenoxyalkanoic acids].
A number of N-oxides of 4'-(benzotriazol-2-yl)-phenylalkanoic and -phenoxyalkanoic acids bearing various substituents on position 6 of benzotriazole together with 4'-(benzotriazol-2-yl) phenylacetic acid were prepared and subjected to a wide pharmacological screening. Several compounds exhibited significant antiinflammatory and diuretic activities, while one was endowed with antihypertensive activity.
Boido
A
A
Istituto di Scienze Farmaceutiche, Università di Genova.
Vazzana
I
I
Sparatore
F
F
Cappello
B
B
Diurno
V
V
Matera
C
C
Marrazzo
R
R
Russo
S
S
Cenicola
M L
ML
Marmo
E
E
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004232:Diuretics / Q000138:chemical synthesis*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014563:Urodynamics / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D002264:Carboxylic Acids; D004232:Diuretics; D014230:Triazoles
Preparazione e attività farmacologica di n-ossidi di acidi 4'-(benzotriazol-2-il)-fenilalcanoici e-fenossialcanoici.