[Thyroid hormone prevention of disorders of cardiac contractile function during stress].
The depression of cardiac contractility has been observed in rats during the immobilized stress in state of relative physiological rest and maximal load. In the animals pretreated with thyroid after stress the indexes of intensity and rate of myocardial contraction and relaxation didn't differ from the control, and during the maximal load the myocardium was characterized by the less expressed decrease of the structure functioning intensity and the higher rate of relaxation. The data obtained show that the physiological doses of thyroid hormones prevent the myocardium from contractile disorders during stress.
Bozhko
A P
AP
Sukhorukova
T A
TA
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006728:Hormones / Q000627:therapeutic use*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D013963:Thyroid Hormones / Q000627:therapeutic use*; D013974:Thyroxine / Q000097:blood
D006728:Hormones; D013963:Thyroid Hormones; C004227:thyroidin; D013974:Thyroxine
Preduprezhdenie tireoidnymi gormonami narusheniĭ sokratitel'noĭ funktsii serdtsa pri stresse.