Proliferation-associated monoclonal antibodies: a useful tool for prognosis in squamous cell carcinomas of head and neck?
Three different proliferation-associated monoclonal antibodies have been studied immunohistochemically to evaluate their prognostic value in patients with squamous cell carcinomas of head and neck. The monoclonal antibody Ki 67 shows a heterogeneous distribution pattern, whereas epidermal growth factor receptor and transferrin receptor expression show a homogeneous one. Concluding from our results the chances to use the described monoclonal antibodies as prognostic markers are limited.
Lörz
M
M
Zentrum der Hals-Nasen-Ohrenheilkunde der Johann Wolfgang-Goeth Universität Frankfurt/Main, FRG.
Meyer-Breiting
E
E
Bettinger
R
R
Desloovere
C
C
Klima
A
A
D000911:Antibodies, Monoclonal; D034961:Antigens, Nuclear; D001324:Autoantigens / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D066246:ErbB Receptors / Q000276:immunology; D006258:Head and Neck Neoplasms / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D009687:Nuclear Proteins / Q000276:immunology; D011379:Prognosis; D011990:Receptors, Transferrin / Q000276:immunology
D000911:Antibodies, Monoclonal; D034961:Antigens, Nuclear; D001324:Autoantigens; D009687:Nuclear Proteins; D011990:Receptors, Transferrin; D066246:ErbB Receptors