title: [Tuberculin sensitivity and tolerance of "direct" BCG vaccination of youths leaving school].
abstract: In 3,296 school-leavers (girls and boys aged 16 years with preceding BCG-vaccination as newborns and without boosting by tuberculin-testing or revaccination during the meantime) simultaneously with compulsory BCG-revaccination tuberculin testing with 2 TU PPD Dessau + Tween 80 was performed in 3 regions of the GDR (Cottbus, Erfurt, Neubrandenburg) in the 2nd half of 1985 and in the 1st quarter of 1986. Sensitivity to tuberculin was found in 7.3% considering reactions with greater than or equal to 6 mm induration as positive, and in 2.9% considering reactions with greater than or equal to 10 mm only. Positive reactions greater than or equal to 6 mm include remaining allergy caused by BCG and non-specific tuberculin sensitivity while a reaction limit greater than or equal to 10 mm is suitable to define tuberculosis infection prevalence. In contrast to studies performed 1973 and 1979 in the same territories a significant decrease in tuberculin sensitivity was evident (43.8% positive reactions (greater than or equal to 6 mm) in 1973 and 11.7% in 1979). The acceptability of "direct" BCG-revaccination has been estimated by evaluation of local reactions 4 weeks after vaccination in 2,123 school-leavers. The ulceration rate in tuberculin positive adolescents was significantly higher than in tuberculin negative. It showed highly significant decrease in comparison with 1979.
authors: Bezirksstelle für Lungenkrankheiten und Tuberkulose, Cottbus, DDR.
authors: H
authors: H
authors: Scharkoff
authors: S
authors: S
authors: Merkel
authors: G
authors: G
authors: Kessler
mesh_terms: D000293:Adolescent; D001500:BCG Vaccine; D005260:Female; D005859:Germany, East / Q000453:epidemiology; D006801:Humans; D008297:Male; D014374:Tuberculin Test; D014376:Tuberculosis / Q000453:epidemiology / Q000517:prevention & control*; D014611:Vaccination
chemical_list: D001500:BCG Vaccine
vernacular_title: Tuberkulin-Sensitivität und Verträglichkeit der "direkten" BCG-Impfung der Schulabgänger.