[The role of cellular immunity in the etiopathogenesis of obstructive bronchitis in childhood].
The development and aetiopathogenetic role of the immune response were studied in group of infants and children aged 4-6 years by comparison of clinical status, concentrations of serum immunoglobulins, virological tests (levels of specific antibodies and cultivation of viruses) and the macrophage migration inhibition test. A respiratory syncytial virus was found in 44% of virologically positive children. The macrophage migration inhibition test was positive in 45% of infants suffering from obstructive bronchitis. The macrophage migration inhibition test was positive in 60% of older children followed up on account of obstructive bronchitis during the two first years of life suffering from repeated diseases of the lower respiratory tract and only in 32% children after clinical recovery. A decrease of concentrations of immunoglobulins IgA, IgG and IgM in blood serum was not observed. The results indicated the fundamental role of cell immunity in the aetiopathogenesis of obstructive bronchitis.
Kostrouchová
M
M
Hlousková
Z
Z
D001991:Bronchitis / Q000209:etiology / Q000276:immunology*; D002464:Cell Migration Inhibition; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis
D007136:Immunoglobulins
Uloha bunĕcné imunity v etiopatogenezi obstrukcní bronchitidy v dĕtském vĕku.