Successive unfolding of two different collagen vascular diseases in the same patient.
Genetic factors may be important in the development of autoimmune disease. We describe the development of fulminant systemic lupus erythematosus in a patient 5 years after recovery from polymyositis. The successive unfolding of different autoimmune diseases in the same individual is suggestive of sequential gene activation.
Gertner
E
E
University of Toronto Rheumatic Disease Unit, Women's College Hospital, ON, Canada.
Goodman
R
R
Gladman
D D
DD
D000974:Antibodies, Antinuclear / Q000032:analysis; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D009220:Myositis / Q000150:complications* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D013997:Time Factors
D000974:Antibodies, Antinuclear; D011241:Prednisone