title: Focal cranial nerve involvement in chronic inflammatory demyelinating polyneuropathy: clinical and MRI evidence of peripheral and central lesions.
abstract: Five cases of chronic inflammatory demyelinating polyneuropathy are described in which cranial nerve involvement accompanied a more generalized neuropathy. Clinical, electrophysiological, radiological and nerve biopsy findings are presented. Cranial nerve lesions in this form of polyneuropathy may be related to lesions of the peripheral nerves or of the central nervous system, when they may be accompanied by MRI evidence of more widespread CNS demyelinating lesions. In cases of early onset, the occurrence of focal cranial nerve lesions may serve to distinguish chronic inflammatory from inherited demyelinating polyneuropathies.
authors: Department of Neurological Science, Royal Free Hospital School of Medicine, London, UK.
authors: H M
authors: HM
authors: Waddy
authors: V P
authors: VP
authors: Misra
authors: R H
authors: RH
authors: King
authors: P K
authors: PK
authors: Thomas
authors: L
authors: L
authors: Middleton
authors: I E
authors: IE
authors: Ormerod
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002493:Central Nervous System Diseases / Q000473:pathology; D002908:Chronic Disease; D003389:Cranial Nerve Diseases / Q000473:pathology*; D003711:Demyelinating Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D009046:Motor Neurons / Q000502:physiology; D011115:Polyneuropathies / Q000473:pathology*; D013127:Spinal Nerves / Q000473:pathology*; D013497:Sural Nerve / Q000473:pathology* / Q000648:ultrastructure