Two different dosages of ciprofloxacin in patients with respiratory tract infections.
Fifty-one patients with chronic obstructive lung disease with a proven bacterial respiratory tract infection were treated with ciprofloxacin 500 mg twice daily or 750 mg twice daily. Both dosages were given orally for approximately 10 days. The higher dosage showed a reduced amount of reinfections and relapses (19% and 16% versus 5% and 0%). The overall results were the same in both groups. Adverse reactions were mild: nausea and visual disturbances were seen in five patients. Eight patients had slight liver test abnormalities. In one patient a seizure occurred. All adverse reactions were of a temporary nature.
Brutel de la Rivière
T
T
Department of Pulmonology, University Hospital Maastricht, the Netherlands.
Daniëls-Bosman
M S
MS
ten Velde
G P
GP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology
D002939:Ciprofloxacin