[Comparative evaluation of the anticoagulant activity of the sodium and calcium salts of heparin, isolated from swine intestinal mucosa].
During in vitro experiments it was shown that at intravenous administration to rabbits and dogs in a dose of 100 IU/kg the anticoagulant effect of mucosal heparin sodium was greater than that of heparin calcium. At subcutaneous administration to rabbits in a dose of 750 IU/kg calcium heparin exhibited a stable and even anticoagulant effect for 12 hours. Mucosal sodium heparin administered subcutaneously caused marked peaks of hypocoagulation and rebound effect. At subcutaneous injection sodium heparin action duration was 10 hours.
Ushkalova
E A
EA
Kremneva
V F
VF
Ovchinnikova
L K
LK
Shcheglova
N V
NV
D000818:Animals; D000925:Anticoagulants / Q000302:isolation & purification; D004285:Dogs; D005260:Female; D006493:Heparin / Q000302:isolation & purification / Q000494:pharmacology*; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007413:Intestinal Mucosa / Q000032:analysis*; D008297:Male; D011817:Rabbits; D013552:Swine
D000925:Anticoagulants; D006493:Heparin
Sravnitel'naia otsenka antikoaguliantnoĭ aktivnosti natrievoĭ i kal'tsievoĭ soleĭ heparina, vydelennogo iz slizistoĭ obolochki kishechnika svineĭ.