Interleukin-1 beta inhibits acetylcholine synthesis in the pituitary corticotropic cell line AtT20.
Pituitary corticotropic AtT20 cells were found to synthesize [3H]acetylcholine, when they were incubated with [3H]choline. Treatment of the cells with picomolar concentrations of human interleukin-1 beta inhibited [3H]acetylcholine production. This effect was specific, since two antisera, directed against human interleukin-1 beta neutralized the inhibitory action of interleukin-1 beta. A possible implication of the inhibitory action of interleukin-1 on acetylcholine production in neuronal transmission disorders is discussed.
Carmeliet
P
P
Laboratory of Cell Pharmacology, School of Medicine, Rega Institute for Medical Research, Leuven, Belgium.
Van Damme
J
J
Denef
C
C
D000109:Acetylcholine / Q000096:biosynthesis*; D000818:Animals; D002460:Cell Line; D007375:Interleukin-1 / Q000494:pharmacology*; D051379:Mice; D010902:Pituitary Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D007375:Interleukin-1; D000109:Acetylcholine