[Use of adsorbed diphtheria-tetanus (DT) toxoid containing different doses of antigens in booster immunizations of children].
To decrease the antigenic load in booster immunizations of children against diphtheria and tetanus, the immunological effectiveness and reactogenicity of different doses of both antigens (i. e 1 Lf and 1 BU; 2.5 Lf and 2.5 BU; 5 Lf and 5 BU) were studied. The study revealed that all these doses of the preparation were practically nonreactogenic: the total of systemic reactions was 0.9%. The study of the immunological effectiveness of adsorbed DT toxoid with reduced antigen content revealed the advantage of the commercial dose of the preparation (5 Lf of diphtheria antigen and 5 BU of tetanus antigen) over such doses of diphtheria and tetanus antigens as, respectively, 1 Lf and 1 BU; 2.5 Lf and 2.5 BU. Still, this advantage disappeared as early as 6 months after booster immunization. The results of these investigations indicate that booster immunization of children aged 6 years and over may be made with lower doses of adsorbed DT toxoid with reduced antigen content.
Egor'kov
N A
NA
Moksimova
N M
NM
Platonova
T V
TV
Chebotareva
S V
SV
Lobanova
A N
AN
D000942:Antigens, Bacterial / Q000008:administration & dosage*; D002648:Child; D004168:Diphtheria Toxoid / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007117:Immunization, Secondary; D013745:Tetanus Toxoid / Q000276:immunology*
D000942:Antigens, Bacterial; D004168:Diphtheria Toxoid; D013745:Tetanus Toxoid
Primenenie ADS-anatoksina, soderzhashchego razlichnye dozy antigenov, pri povtornykh revaktsinatsiiakh deteĭ.