Local intraarterial fibrinolysis in acute vertebrobasilar occlusion. Technical developments and recent results.
Local intraarterial fibrinolytic therapy (LIF) in patients with acute vertebrobasilar occlusion (AVBO) is a rational and if successful a life saving treatment. The recent progress in this field is determined by the use of microcatheters for superselective basilar artery catheterisation and a "short time, highdose" regimen using 750.000 IU Urokinase in not more than two h. Two out of 7 patients died and 1 did not improve to a better than a locked-in-state. Four patients however survived with excellent outcome.
Zeumer
H
H
Department of Neuroradiology, University Hospital Eppendorf, Hamburg, Federal Republic of Germany.
Freitag
H J
HJ
Grzyska
U
U
Neunzig
H P
HP
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001488:Basilar Artery / Q000000981:diagnostic imaging; D006801:Humans; D007261:Infusions, Intra-Arterial; D008722:Methods; D008875:Middle Aged; D011379:Prognosis; D011859:Radiography; D012189:Retrospective Studies; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage* / Q000627:therapeutic use; D014711:Vertebral Artery / Q000000981:diagnostic imaging; D014715:Vertebrobasilar Insufficiency / Q000000981:diagnostic imaging / Q000188:drug therapy*
D014568:Urokinase-Type Plasminogen Activator