[Polyclonal B-cell activation by so-called immunopotentiation (immunostimulants)].
Immuno-augmentation with substances of bacterial origin was studied in vitro for its ability to induce polyclonal B-cell activation. Biostim, Broncho-Vaxom, Omnadin, Paspat and OK 432 were compared for their B-cell mitogenicity with classical polyclonal B-cell activators (Staph. aureus Cowan I, KlebsM, Pokeweed mitogen). B-cell mitogenicity, as measured by 3H-thymidine incorporation into proliferating blood B-cells, was not induced by any of the studied preparations. On the other hand, OK 432 produced a T-cell dependent and Biostim a T-cell independent blood B-cell differentiation in immunoglobulin producing cells. However, the extent of immunoglobulin production was clearly less than with the polyclonal B-cell activator KlebsM. These results demonstrate that, in some of the preparations, in vivo polyclonal B-cell activation can be expected to occur.
Kekow
J
J
I. Medizinische Universitätsklinik Kiel.
Hobusch
G
G
Lüdemann
J
J
Gross
W L
WL
D000276:Adjuvants, Immunologic / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D001419:Bacteria / Q000276:immunology; D002454:Cell Differentiation; D002455:Cell Division; D002478:Cells, Cultured; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D007709:Klebsiella / Q000276:immunology; D008213:Lymphocyte Activation; D010844:Picibanil / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000276:immunology
D000276:Adjuvants, Immunologic; D007075:Immunoglobulin M; D011043:Pokeweed Mitogens; D010844:Picibanil
Polyklonale B-Zellaktivierung durch sogenannte Umstimmungsmittel ("Immunstimulantien").