title: Synthesis and biological activity of the two isomeric 2'-C-methyl daunomycins.
abstract: The title new daunorubicin analogues have been prepared from methyl 4,6-O-benzylidene-2-C-methyl-alpha-D-ribo-hexopyranosid-3-ulose and daunomycinone. The antitumor activity of these compounds was very similar to that of daunorubicin.
authors: Institut de Chimie des Substances Naturelles du C.N.R.S., Gif-sur-Yvette, France.
authors: V
authors: V
authors: Rocherolle
authors: A
authors: A
authors: Olesker
authors: G
authors: G
authors: Lukacs
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use; D007941:Leukemia P388 / Q000188:drug therapy; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000903:Antibiotics, Antineoplastic; C061226:2'-C-methyldaunomycin; D003630:Daunorubicin