Clinical implications of the epidermal growth factor receptor in the squamous cell carcinoma of the uterine cervix.
The clinical implications of the epidermal growth factor (EGF) and its receptor (EGF-R) were studied in 52 squamous cell carcinomas of the uterine cervix. In comparison to 40 biopsies of the normal cervix EGF-R capacity was significantly increased in the carcinomas, while the affinity was unchanged. The amount of EGF-like substances extracted from the tumors was increased in patients with lymph node metastases, in whom 5-year survival is reduced. Irrespective of tumor stage patients with a very high level of EGF-R (greater than 100 fmole/mg protein) were more likely to have recurrences later or to die from disease: recurrence or death occurred in 5 of 7 patients with high capacity and in 2 of 45 patients with low capacity. Our data suggest that the level of EGF-R is indicative of the biological aggressiveness of cervical carcinomas.
Pfeiffer
D
D
Department of Obstetrics and Gynecology, Klinikum Grosshadern, Ludwig Maximilians Universitaet, Muenchen, Germany.
Stellwag
B
B
Pfeiffer
A
A
Borlinghaus
P
P
Meier
W
W
Scheidel
P
P
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000032:analysis* / Q000401:mortality / Q000473:pathology; D002584:Cervix Uteri / Q000032:analysis; D004815:Epidermal Growth Factor / Q000032:analysis; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D002583:Uterine Cervical Neoplasms / Q000032:analysis* / Q000401:mortality / Q000473:pathology
D004815:Epidermal Growth Factor; D066246:ErbB Receptors