title: Characterization of technetium-99m-L,L-ECD for brain perfusion imaging, Part 1: Pharmacology of technetium-99m ECD in nonhuman primates.
abstract: Technetium-99m ethyl cysteinate dimer ([99mTc]ECD) is a neutral, lipophilic complex which rapidly crosses the blood-brain barrier. Brain retention and tissue metabolism of [99mTc]ECD is dependent upon the stereochemical configuration of the complex. While both L,L and D,D enantiomers are extracted by the brain, only the L,L but not the D,D form, is metabolized and retained in the monkey brain (4.7% injected dose initially, T 1/2 greater than 24 hr). Dynamic single photon emission computed tomography imaging studies in one monkey indicates 99mTc-L,L-ECD to be distributed in a pattern consistent with regional cerebral blood flow for up to 16 hr postinjection. Dual-labeled 99mTc-L,L-ECD and [14C]iodoantipyrine autoradiography studies performed 1 hr after administration show cortical gray to white matter ratios of both isotopes to be equivalent (approximately 4-5:1). These data suggest that 99mTc-L,L-ECD will be useful for the scintigraphic assessment of cerebral perfusion in humans.
authors: Medical Products Department, E.I. Du Pont de Nemours & Co., Inc., No. Billerica, MA 01862.
authors: R C
authors: RC
authors: Walovitch
authors: T C
authors: TC
authors: Hill
authors: S T
authors: ST
authors: Garrity
authors: E H
authors: EH
authors: Cheesman
authors: B A
authors: BA
authors: Burgess
authors: D H
authors: DH
authors: O'Leary
authors: A D
authors: AD
authors: Watson
authors: M V
authors: MV
authors: Ganey
authors: R A
authors: RA
authors: Morgan
authors: S J
authors: SJ
authors: Williams
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives; D001345:Autoradiography / Q000379:methods; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000378:metabolism; D002250:Carbon Radioisotopes; D002560:Cerebrovascular Circulation; D003545:Cysteine / Q000031:analogs & derivatives*; D008253:Macaca mulatta; D008297:Male; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013347:Subcellular Fractions / Q000378:metabolism; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D002250:Carbon Radioisotopes; D015609:Organotechnetium Compounds; C059659:technetium Tc 99m bicisate; D003545:Cysteine; D000983:Antipyrine; C008135:iodoantipyrine