[In vitro corneal endothelial damage caused by intraocular lenses of PMMA, silicone and polyhema].
We compared the endothelial damage to freshly excised pig corneas (n = 156) as a result of contact with IOLs made of PMMA, silicone and polyhema. The contact time was 15 s, 1 min and 30 min. The endothelial damage was quantified with the Janus green vital staining photometric technique. Morphological changes were evaluated by scanning electron microscopy. The most damage was caused by PMMA (7.6%; 10.2%; 19.7%), followed by silicone (4.8%; 6.8%; 10.2%) and polyhema (4.6%; 5.9%; 8.3%). The degree of endothelial damage was statistically significant (P less than 0.01) in comparison with the control groups without any relationship to lens material or contact time. There was no significant difference between the damage caused by silicone and polyhema, but there was a significant difference between PMMA and silicone or polyhema.
Pharmakakis
N
N
Hartmann
C
C
Bergmann
L
L
D000818:Animals; D046508:Culture Techniques; D004728:Endothelium, Corneal / Q000187:drug effects*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D007910:Lenses, Intraocular; D008768:Methylmethacrylates / Q000633:toxicity*; D011092:Polyethylene Glycols / Q000633:toxicity*; D012828:Silicones / Q000633:toxicity*; D013552:Swine
D008768:Methylmethacrylates; D012828:Silicones; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols
In vitro Hornhautendothelschädigung durch intraokulare Linsen aus PMMA, Silikon und Polyhema.