Testosterone in a cyclodextrin-containing formulation: behavioral and physiological effects of episode-like pulses in rats.
Testosterone, administered in the form of an inclusion complex with 2-hydroxypropyl-beta-cyclodextrin by subcutaneous injection, enters the circulation in a manner markedly similar to the natural episodic release by the testes. The effects of a regimen of once-a-day administration of complexed testosterone to adult (castrated or intact) rats and to senescent (intact) rats were investigated. Although this procedure left the castrated animals with concentrations of circulatory hormone far below physiological levels for much of the day, a significant improvement in androgen-sensitive behavior and physiology was obtained. Furthermore, the testosterone effects were more pronounced when high doses were used periodically rather than when the same total amount of testosterone was equally divided among doses. The same supplementation to intact rats intensified androgen-sensitive behavior and physiology over normal levels. In senescent rats uniform pulses of the testosterone complex also improved behavior and physiology. Specifically, spermatogenesis was stimulated and, notably, the treatment increased muscle weight without substantial enlargement of the prostate. Since the testosterone-cyclodextrin complex also can be effectively administered as a sublingual tablet, the data suggest that similar regimens may be recommended for elderly men suffering from decreases in muscle mass.
Taylor
G T
GT
University of Missouri, St. Louis 63121.
Weiss
J
J
Pitha
J
J
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins / Q000032:analysis; D005260:Female; D008297:Male; D009132:Muscles / Q000187:drug effects; D009919:Orchiectomy; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D013739:Testosterone / Q000008:administration & dosage / Q000494:pharmacology*
D003505:Cyclodextrins; D013739:Testosterone