Independent clinical significance of HIV antigen determination and CD4 counts in anti-HIV positive patients.
HIV antigenemia was found in 52/243 HIV antibody positive individuals attending 2 AIDS-screening clinics, giving a prevalence of 13, 25 and 76% in CDC groups II, III and IV, respectively. No correlation was found to decreased CD4 lymphocyte values in the individual groups. HIV antigen therefore identified a separate subpopulation. For 138 asymptomatic patients followed prospectively both laboratory parameters predicted HIV-related events, the relative risk factor being 4 for low CD4 value and 6 for presence of HIV antigen. Individuals presenting with HIV antigen and decreased CD4 count all developed disease within 18 months, the relative risk factor being 24. Thus the 2 markers, when measured together, effectively separated asymptomatic HIV-infected patients into 1 of 3 risk categories.
Skinhøj
P
P
Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Hofmann
B
B
Jacobsen
K D
KD
Lerche
B
B
Frederiksen
B
B
Bygbjerg
I C
IC
Petersen
C S
CS
Dickmeiss
E
E
Svejgaard
A
A
D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D015483:HIV Antibodies / Q000032:analysis; D015488:HIV Antigens / Q000032:analysis*; D006679:HIV Seropositivity; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors
D000945:Antigens, Differentiation, T-Lymphocyte; D015483:HIV Antibodies; D015488:HIV Antigens